PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 29792808-8 2018 Following PAR treatment, the production of IL-2, IFN-gamma, IL-6, and TNF-alpha could be significantly reduced by an infusion of clinically relevant concentrations of the FDA-approved antibiotic, trimethoprim, signaling pharmacologic PAR deactivation. paratose 10-13 interferon gamma Homo sapiens 49-58 29792808-8 2018 Following PAR treatment, the production of IL-2, IFN-gamma, IL-6, and TNF-alpha could be significantly reduced by an infusion of clinically relevant concentrations of the FDA-approved antibiotic, trimethoprim, signaling pharmacologic PAR deactivation. Trimethoprim 196-208 interferon gamma Homo sapiens 49-58 30031388-2 2018 Moreover, results of plasma total mRNAs after delta-tocotrienol feeding to hepatitis C patients revealed significant inhibition in the expression of pro-inflammatory cytokines (TNF-alpha, VCAM1, proteasome subunits) and induction in the expression of ICAM1 and IFN-gamma after post-treatment. tocotrienol, delta 46-63 interferon gamma Homo sapiens 261-270 30031388-11 2018 The IPA of "diseases and functions" regulators (85) were involved with cAMP, STAT2, 26S proteasome, CSF1, IFNgamma, LDL, TGFA, and microRNA-155-5p, miR-223, miR-21-5p. Cyclic AMP 71-75 interferon gamma Homo sapiens 106-114 30078983-9 2018 Results: The CE-CKC emulsions decreased inflammatory gene expression in LPS-stimulated PBMCs (IFN-gamma, IL-17A, CXCL-9, and TNFalpha) and LPS-stimulated HCE-2 cells (THBS1 and CCL2). CKC 16-19 interferon gamma Homo sapiens 94-103 30078983-10 2018 Both CE-CKC emulsions inhibited the secretion of IL-17 (from anti-CD3/anti-CD28-stimulated TCD4), TNFalpha, IFN-gamma, and IL-2 (from anti-CD3-/anti-CD28-stimulated PBMCs), and IL-6 and IL-8 (from LPS-stimulated HCE-2). ce-ckc 5-11 interferon gamma Homo sapiens 108-117 30072983-0 2018 A Synthetic Disaccharide Derivative of Diphyllin, TAARD, Activates Human Natural Killer Cells to Secrete Interferon-Gamma via Toll-Like Receptor-Mediated NF-kappaB and STAT3 Signaling Pathways. Disaccharides 12-24 interferon gamma Homo sapiens 105-121 30072983-0 2018 A Synthetic Disaccharide Derivative of Diphyllin, TAARD, Activates Human Natural Killer Cells to Secrete Interferon-Gamma via Toll-Like Receptor-Mediated NF-kappaB and STAT3 Signaling Pathways. diphyllin 39-48 interferon gamma Homo sapiens 105-121 30072983-7 2018 STAT3 and NF-kappaB knockdown with lentivirus shRNA as well as the NF-kappaB-specific inhibitor, N-tosyl-l-phenylalaninechloromethyl ketone, significantly suppressed TAARD-induced IFN-gamma generation in primary NK cells. Tosylphenylalanyl Chloromethyl Ketone 97-139 interferon gamma Homo sapiens 180-189 30072983-9 2018 Collectively, our data suggest that TAARD can induce NK cell IFN-gamma production through TLR1-NF-kappaB and TLR3-STAT3 signaling pathways, rendering its potential use as an agent for cancer prevention or treatment. taard 36-41 interferon gamma Homo sapiens 61-70 30021162-6 2018 Elevated IFN-gamma within the tumor microenvironment suggests that MS-275 modulates the local cytokine landscape to favor antitumor myeloid polarization through the IFN-gammaR/STAT1 signaling axis. entinostat 67-73 interferon gamma Homo sapiens 9-18 29746817-0 2018 Arginine inhibits the malignant transformation induced by interferon-gamma through the NF-kappaB-GCN2/eIF2alpha signaling pathway in mammary epithelial cells in vitro and in vivo. Arginine 0-8 interferon gamma Homo sapiens 58-74 30011861-10 2018 Decidualizing cultures with 1,25-dihydroxvitamin D3 (1,25[OH]2VD) decreased IFN-gamma. 1,25-dihydroxvitamin d3 28-51 interferon gamma Homo sapiens 76-85 29746817-5 2018 The results indicate that arginine addition could alleviate the malignant transformation of mammary epithelial cells induced by IFN-gamma, including reducing cell proliferation, cell migration and colony formation, through the NF-kappaB-GCN2/eIF2alpha pathway. Arginine 26-34 interferon gamma Homo sapiens 128-137 29746817-7 2018 Furthermore, the investigation of the clinical data also revealed that the plasma or tissue from human breast cancer patients owned lower arginine level and higher IFN-gamma level than that from patients with benign breast disease, showing IFN-gamma may be a potential control target. Arginine 138-146 interferon gamma Homo sapiens 240-249 29746817-8 2018 Our findings demonstrate that arginine supplement could antagonize the malignant transformation of mammary epithelial cells induced by IFN-gamma (nutritionally induced) both in vitro and in vivo, and IFN-gamma was higher in breast cancer women. Arginine 30-38 interferon gamma Homo sapiens 135-144 29746817-8 2018 Our findings demonstrate that arginine supplement could antagonize the malignant transformation of mammary epithelial cells induced by IFN-gamma (nutritionally induced) both in vitro and in vivo, and IFN-gamma was higher in breast cancer women. Arginine 30-38 interferon gamma Homo sapiens 200-209 29980703-5 2018 We also characterised their effects in ex-vivo psoriasis PBMC and report that curcumin, but not carnosol, strongly reduces T cell proliferation and cytokine poly-functionality, with reduced expression of psoriatic cytokines IFNgamma, IL-17, GM-CSF and IL-22. Curcumin 78-86 interferon gamma Homo sapiens 224-232 29678503-6 2018 Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment. Caffeine 129-137 interferon gamma Homo sapiens 42-51 30123049-6 2018 The secretion of cytokines (IL-6, IL-2 and IFN-gamma) was suppressed in response to ibrutinib. ibrutinib 84-93 interferon gamma Homo sapiens 43-52 30349892-9 2018 Macrophages activated by IFNgamma and TNFalpha upregulated IDO1 expression, increased the Kyn/Trp ratio and enhanced TF expression and activity, but not TF pathway inhibitor expression. Tryptophan 94-97 interferon gamma Homo sapiens 25-33 30001736-10 2018 Production of interferon-gamma and tumor necrosis factor-alpha by CD4+ T cells from PD patients is increased and maintained in the presence of homologous Treg. treg 154-158 interferon gamma Homo sapiens 14-62 29688330-7 2018 The partial agonist effect of glycolipid XZ7, inducing cytotoxicity and IFN-gamma production but not IL-4 production, indicates that specific protumour activities of iNKT cells can be abolished, while preserving their antitumor activities, by introducing structural modifications to alpha-GalCer. Glycolipids 30-40 interferon gamma Homo sapiens 72-81 29688330-7 2018 The partial agonist effect of glycolipid XZ7, inducing cytotoxicity and IFN-gamma production but not IL-4 production, indicates that specific protumour activities of iNKT cells can be abolished, while preserving their antitumor activities, by introducing structural modifications to alpha-GalCer. Runcaciguat 41-44 interferon gamma Homo sapiens 72-81 29968330-5 2018 RESULTS: CitHSP90beta induced significantly higher levels of interferon-gamma (IFN-gamma) levels in RA-ILD (interstitial lung abnormalities = 2 + 3) groups compared to the RA-no ILD group (P = 0.01), but did not stimulate the production of other cytokines (P > 0.05). cithsp90beta 9-21 interferon gamma Homo sapiens 61-77 29520060-5 2018 Kynurenine levels were significantly correlated with levels of interferon-gamma (p < .001), which is involved in the regulation of IDO, in both patients and controls. Kynurenine 0-10 interferon gamma Homo sapiens 63-79 29194614-6 2018 Despite their partial negative effect on NK cell proliferation, FSK-MSCs boosted the capacity of activated NK-cells to secrete IFN-gamma and TNF-alpha. fsk 64-67 interferon gamma Homo sapiens 127-136 29256181-10 2018 Retinol reduced IFNgamma in GO and control fibroblasts. Vitamin A 0-7 interferon gamma Homo sapiens 16-24 29968330-5 2018 RESULTS: CitHSP90beta induced significantly higher levels of interferon-gamma (IFN-gamma) levels in RA-ILD (interstitial lung abnormalities = 2 + 3) groups compared to the RA-no ILD group (P = 0.01), but did not stimulate the production of other cytokines (P > 0.05). cithsp90beta 9-21 interferon gamma Homo sapiens 79-88 29712731-0 2018 Characterization of Chlamydial Rho and the Role of Rho-Mediated Transcriptional Polarity during Interferon Gamma-Mediated Tryptophan Limitation. Tryptophan 122-132 interferon gamma Homo sapiens 96-112 30002661-8 2018 In naive CD4+ T cells, IFN-alpha and IFN-gamma induced phosphorylation of STAT1, which was inhibited by baricitinib and tofacitinib. baricitinib 104-115 interferon gamma Homo sapiens 37-46 30002661-8 2018 In naive CD4+ T cells, IFN-alpha and IFN-gamma induced phosphorylation of STAT1, which was inhibited by baricitinib and tofacitinib. tofacitinib 120-131 interferon gamma Homo sapiens 37-46 29743310-5 2018 Additionally, we document a high degree of correlation between IFN-gamma levels in the QFT-GIT TB antigen tube and each of the two QFT-Plus TB antigen tubes, as well as between the QFT-Plus TB1 and TB2 tubes (Pearson"s correlation coefficients [R] > 0.95). Terbium 95-97 interferon gamma Homo sapiens 63-72 29743310-5 2018 Additionally, we document a high degree of correlation between IFN-gamma levels in the QFT-GIT TB antigen tube and each of the two QFT-Plus TB antigen tubes, as well as between the QFT-Plus TB1 and TB2 tubes (Pearson"s correlation coefficients [R] > 0.95). Terbium 140-142 interferon gamma Homo sapiens 63-72 29712731-2 2018 When human epithelial cells are treated with the cytokine interferon gamma (IFN-gamma), the tryptophan (Trp)-degrading enzyme, indoleamine-2,3-dioxygenase, is induced. Tryptophan 92-102 interferon gamma Homo sapiens 58-85 29712731-2 2018 When human epithelial cells are treated with the cytokine interferon gamma (IFN-gamma), the tryptophan (Trp)-degrading enzyme, indoleamine-2,3-dioxygenase, is induced. Tryptophan 104-107 interferon gamma Homo sapiens 58-85 29973928-7 2018 P4 suppresses and RU486 enhances antigen-specific CD4 and CD8 T cell inflammatory cytokine (IFN-gamma) and cytotoxic molecule release (granzyme B). Mifepristone 18-23 interferon gamma Homo sapiens 92-101 29644860-4 2018 Carbamazepine-specific CD4+ T-cells that proliferated to the greatest extent and secreted the highest levels of IFN-gamma showed an up-regulation of miR-18a and miR-155. Carbamazepine 0-13 interferon gamma Homo sapiens 112-121 29946223-10 2018 IFNgamma/AZD5582-induced cell death in NSCLC cells was independent of TNFalpha autocrine but relied on apoptosis mediated by JAK kinase, caspase 8 and RIPK1 pathways. N,N'-(2,2'-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-(2-cyclohexyl-2-(2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide) 9-16 interferon gamma Homo sapiens 0-8 29911570-6 2018 Instead, chronic T cells appeared to rely on oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) to produce ATP for IFNgamma synthesis. Adenosine Triphosphate 122-125 interferon gamma Homo sapiens 130-138 29946223-8 2018 IFNgamma co-treatment with a novel class dimeric Smac mimetic AZD5582 eradicated NSCLC cell colony formation. N,N'-(2,2'-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-(2-cyclohexyl-2-(2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide) 62-69 interferon gamma Homo sapiens 0-8 29915579-15 2018 IFN-gamma was found to strengthen poly(dA:dT)-induced cell pyroptosis and bioactive IL-18 release. poly 34-38 interferon gamma Homo sapiens 0-9 29935534-0 2018 Naturally occurring 3RS, 7R, 11R-phytanic acid suppresses in vitro T-cell production of interferon-gamma. 3rs, 7r, 11r-phytanic acid 20-46 interferon gamma Homo sapiens 88-104 29935534-8 2018 RESULTS: 3RS, 7R, 11R-PA significantly reduced in vitro IFN-gamma production at both the protein and mRNA levels, and was accompanied by decreased expression of T-bet, a key regulator of Th1 cell differentiation. 7r 14-16 interferon gamma Homo sapiens 56-65 29935534-8 2018 RESULTS: 3RS, 7R, 11R-PA significantly reduced in vitro IFN-gamma production at both the protein and mRNA levels, and was accompanied by decreased expression of T-bet, a key regulator of Th1 cell differentiation. 11r-pa 18-24 interferon gamma Homo sapiens 56-65 29891009-11 2018 CTLA-4 blockade increased IFNgamma expression, but not IL-2, in stimulated human peripheral blood T cells exposed to dexamethasone. Dexamethasone 117-130 interferon gamma Homo sapiens 26-34 29915579-15 2018 IFN-gamma was found to strengthen poly(dA:dT)-induced cell pyroptosis and bioactive IL-18 release. amsonic acid 39-41 interferon gamma Homo sapiens 0-9 29915579-15 2018 IFN-gamma was found to strengthen poly(dA:dT)-induced cell pyroptosis and bioactive IL-18 release. Thymidine 42-44 interferon gamma Homo sapiens 0-9 29292524-8 2018 When stimulated with PMA/ionomycin, CD4+ T cells from women with EP presented significantly higher interferon (IFN)-gamma and interleukin (IL)-17 secretion, and lower transforming growth factor (TGF)-beta secretion. Tetradecanoylphorbol Acetate 21-24 interferon gamma Homo sapiens 99-121 29643245-7 2018 The recombinant MLV SUV-IL-15 significantly increased the numbers of gamma interferon (IFN-gamma)-producing cells in circulation at 49 days postvaccination (dpv), especially for IFN-gamma-producing CD4- CD8+ T cells and gammadelta T cells, compared to the Suvaxyn MLV and SUV-IL-18. diperoxovanadate 157-160 interferon gamma Homo sapiens 69-96 29643245-7 2018 The recombinant MLV SUV-IL-15 significantly increased the numbers of gamma interferon (IFN-gamma)-producing cells in circulation at 49 days postvaccination (dpv), especially for IFN-gamma-producing CD4- CD8+ T cells and gammadelta T cells, compared to the Suvaxyn MLV and SUV-IL-18. diperoxovanadate 157-160 interferon gamma Homo sapiens 87-96 29292524-8 2018 When stimulated with PMA/ionomycin, CD4+ T cells from women with EP presented significantly higher interferon (IFN)-gamma and interleukin (IL)-17 secretion, and lower transforming growth factor (TGF)-beta secretion. Ionomycin 25-34 interferon gamma Homo sapiens 99-121 29532855-3 2018 In the present study, the biological effects of an RA methanol extract (RAME) on inflammation were investigated in tumor necrosis factor-alpha (TNF-alpha)/interferon-gamma (IFN-gamma)-stimulated human keratinocytes. Methanol 54-62 interferon gamma Homo sapiens 173-182 29569512-7 2018 In addition, DpTTDp lacked relevant IgE-reactivity, induced low T-cell proliferation and IFN-gamma in peripheral blood mononuclear cells of HDM-allergic patients" sera. dpttdp 13-19 interferon gamma Homo sapiens 89-98 29600327-7 2018 In fully differentiated M1 macrophages, histamine or ST-1006 decreased the IFN-Y- and LPS-induced CCL4 mRNA expression and protein production, whereas CCL3 or IL-23 production was not regulated via H4R. Histamine 40-49 interferon gamma Homo sapiens 75-80 29600327-7 2018 In fully differentiated M1 macrophages, histamine or ST-1006 decreased the IFN-Y- and LPS-induced CCL4 mRNA expression and protein production, whereas CCL3 or IL-23 production was not regulated via H4R. N4-(2,6-dichlorobenzyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine 53-60 interferon gamma Homo sapiens 75-80 29058810-11 2018 However, upregulation of miR-302a-3p is observed when IFNgamma suppressed RANKL expression in PGE2 -stimulated HMOBs. Dinoprostone 94-98 interferon gamma Homo sapiens 54-62 29666190-3 2018 Tryptophanyl-tRNA synthetase (TrpRS) is also highly expressed in IFN-gamma-treated cells and also has high affinity and selectivity for Trp. Tryptophan 30-33 interferon gamma Homo sapiens 65-74 29666190-4 2018 Here, we investigated the effects of human TrpRS expression on Trp uptake into IFN-gamma-treated human THP-1 monocytes or HeLa cells. Tryptophan 43-46 interferon gamma Homo sapiens 79-88 29478292-5 2018 RESULTS: Drug-specific IFN-gamma-releasing cells were detectable in 73.9% of SCAR subjects (55.6% and 85.7% in patients who were and were not taking systemic steroids, respectively), whereas LTT results were positive in 52.2% of SCAR subjects. Steroids 158-166 interferon gamma Homo sapiens 23-32 29058810-14 2018 In contrast, silencing of miR-302a-3p by its inhibitor increased RANKL expression in PGE2 -IFNgamma conditioned HMOBs. Dinoprostone 85-89 interferon gamma Homo sapiens 91-99 29058810-15 2018 miR-302a-3p regulates RANKL expression in HMOBs within PGE2 -IFNgamma regulatory network. Dinoprostone 55-59 interferon gamma Homo sapiens 61-69 29501468-10 2018 Moderate direct correlations were observed between vitamin D and IL-8, IL-10, and IFN-gamma in the prospective group of 16 brain-dead patients (IL-8: r = 0.5, p = 0.049; IL-10 r = 0.67, p = 0.005; IFN-gamma r = 0.6, p = 0.015). Vitamin D 51-60 interferon gamma Homo sapiens 82-91 29701883-6 2018 Additionally, TLA induced IFN-gamma production in iNKT cells from patients with ACL, while in iNKT of patients with AVL, TLA induced a decrease in this cytokine. tert-butyl acetate 14-17 interferon gamma Homo sapiens 26-35 29583060-7 2018 RESULTS: The results showed that PAPep effectively decreased mRNA and protein expression of IL-6, MCP-1, and IFN-gamma in corneal fibroblasts exposed to poly(I:C). poly 153-157 interferon gamma Homo sapiens 109-118 29501468-13 2018 In brain-dead patients, vitamin D serum levels correlated with plasma IL-8, IL-10 and IFN-gamma. Vitamin D 24-33 interferon gamma Homo sapiens 86-95 29892290-6 2018 However, IL-4 was only weakly expressed, and PMA and ionomycin restimulation favored IFN-gamma over IL-4 expression. Ionomycin 53-62 interferon gamma Homo sapiens 85-94 29951107-4 2018 Total flavonoids isolated from RG (TFRG) exhibited anti-inflammatory activity through the regulation of ERK/NF-kappaB/miR-155 signaling and suppression of iNOS expression in LPS/IFN-gamma stimulated RAW264.7 macrophages without cytotoxicity. Flavonoids 6-16 interferon gamma Homo sapiens 178-187 29688129-5 2018 BScoIFNG produced 1.53 fold higher hIFNG using glucose-based defined medium as compared to the complex medium by modulating the physiological parameter growth rate from 0.35 to 0.26 hr-1. Glucose 47-54 interferon gamma Homo sapiens 35-40 29688129-7 2018 Sorbitol and glycerol emerged as the best hIFNG producers with lowest growth and substrate consumption rates. Sorbitol 0-8 interferon gamma Homo sapiens 42-47 29688129-7 2018 Sorbitol and glycerol emerged as the best hIFNG producers with lowest growth and substrate consumption rates. Glycerol 13-21 interferon gamma Homo sapiens 42-47 29688129-8 2018 BScoIFNG produced maximum 3.15 mg L-1 hIFNG at 50 g L-1 glycerol with highest hIFNG yield (Yp/x = 0.136) and lowest substrate uptake rate (qs = 0.26). Glycerol 56-64 interferon gamma Homo sapiens 38-43 29688129-8 2018 BScoIFNG produced maximum 3.15 mg L-1 hIFNG at 50 g L-1 glycerol with highest hIFNG yield (Yp/x = 0.136) and lowest substrate uptake rate (qs = 0.26). Glycerol 56-64 interferon gamma Homo sapiens 78-83 29861472-5 2018 We have recently reported that Treg-induced Foxp3 binds the interleukin-2 (IL-2), interferon-gamma (IFN- gamma), and tumor necrosis factor-alpha (TNF-alpha) promoters in virus-specific CD8+ T cells. treg 31-35 interferon gamma Homo sapiens 82-98 29861472-5 2018 We have recently reported that Treg-induced Foxp3 binds the interleukin-2 (IL-2), interferon-gamma (IFN- gamma), and tumor necrosis factor-alpha (TNF-alpha) promoters in virus-specific CD8+ T cells. treg 31-35 interferon gamma Homo sapiens 100-110 29951107-4 2018 Total flavonoids isolated from RG (TFRG) exhibited anti-inflammatory activity through the regulation of ERK/NF-kappaB/miR-155 signaling and suppression of iNOS expression in LPS/IFN-gamma stimulated RAW264.7 macrophages without cytotoxicity. tfrg 35-39 interferon gamma Homo sapiens 178-187 29769377-8 2018 The levels of IFN-gamma and IL-2 were significantly elevated in those subjects not receiving triazole antifungal therapy compared to those who were receiving triazole antifungal therapy. Triazoles 93-101 interferon gamma Homo sapiens 14-23 29777119-2 2018 The production of IFNgamma by T cells was evaluated at baseline and after 1, 2, 4, and 8 years of anti-TNF agents by means of a QuantiFERON-TB Gold In-Tube assay. tb gold 140-147 interferon gamma Homo sapiens 18-26 29799015-6 2018 Addition of cyclic-di-GMP induced a transient increase in IFN-gamma production. bis(3',5')-cyclic diguanylic acid 12-25 interferon gamma Homo sapiens 58-67 29769377-8 2018 The levels of IFN-gamma and IL-2 were significantly elevated in those subjects not receiving triazole antifungal therapy compared to those who were receiving triazole antifungal therapy. Triazoles 158-166 interferon gamma Homo sapiens 14-23 29649742-6 2018 In contrast to the quinolinone derivatives, the antagonistic effects of the quinoline compounds (16c and 17k) were paralleled by their ability to inhibit the release of the pro-inflammatory cytokine, IL-1beta, from LPS/IFN-gamma/BzATP-stimulated THP-1 cells (IC50 of 7 and 12 nM, respectively). quinoline 76-85 interferon gamma Homo sapiens 219-228 29795984-0 2018 Reexamining IFN-gamma Stimulation of De Novo NAD+ in Monocyte-Derived Macrophages. NAD 45-49 interferon gamma Homo sapiens 12-21 29668284-4 2018 Surprisingly, although the treatment of both HCQ and UC-MSCs could ameliorate renal damage separately, the presence of HCQ decreased unexpectedly the therapeutic effects of UC-MSCs through interfering expression of IFN-gamma. Hydroxychloroquine 119-122 interferon gamma Homo sapiens 215-224 29352737-7 2018 The addition of 2 5 ng/ml cyclosporin A and 1 microM prednisolone inhibit IFN-gamma/TNF-alpha production significantly by CD8+ Pgp+ T cells from BOS patients. Cyclosporine 26-39 interferon gamma Homo sapiens 74-83 29438524-0 2018 Elevated Cyclic AMP Inhibits Mycobacterium tuberculosis-Stimulated T-cell IFN-gamma Secretion Through Type I Protein Kinase A. Cyclic AMP 9-19 interferon gamma Homo sapiens 74-83 29438524-2 2018 We determined the levels of cAMP in peripheral blood mononuclear cells (PBMC) from tuberculosis patients and the mechanisms for cAMP suppression of IFN-gamma production. Cyclic AMP 128-132 interferon gamma Homo sapiens 148-157 29254929-10 2018 Lesional T cells responded to tofacitinib with reduced proliferation rates (<10%) and minimal production of the effector molecules interferon-gamma, interleukin-17, and interleukin-21. tofacitinib 30-41 interferon gamma Homo sapiens 134-150 29438524-5 2018 PKA type I specific cAMP analogs inhibited Mtb-stimulated IFN-g production by PBMC through suppression of Mtb-induced IFN-gamma promoter binding activities of CREB, ATF-2, and c-Jun and also miR155, the target miRNA of these transcription factors. Cyclic AMP 20-24 interferon gamma Homo sapiens 118-127 29494963-11 2018 Moreover, overexpression of miR-24 inhibited secretions of IFN-gamma and TNF-alpha, and decreased cytotoxicity by downregulating Paxillin expression. mir-24 28-34 interferon gamma Homo sapiens 59-68 29352737-7 2018 The addition of 2 5 ng/ml cyclosporin A and 1 microM prednisolone inhibit IFN-gamma/TNF-alpha production significantly by CD8+ Pgp+ T cells from BOS patients. Prednisolone 53-65 interferon gamma Homo sapiens 74-83 29739054-9 2018 The results demonstrated that high-glucose could increase the proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), interferon-gamma (INF-gamma), and transforming growth factor-beta (TGF-beta), while these effects were reduced when treated with dioscin (p < 0.05). Glucose 35-42 interferon gamma Homo sapiens 138-154 29352737-8 2018 The addition of 10 microM Compound A and 1 microM prednisolone inhibit IFN-gamma/TNF-alpha production significantly by CD8+ Pgp- T cells from BOS patients. Prednisolone 50-62 interferon gamma Homo sapiens 71-80 29739054-9 2018 The results demonstrated that high-glucose could increase the proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), interferon-gamma (INF-gamma), and transforming growth factor-beta (TGF-beta), while these effects were reduced when treated with dioscin (p < 0.05). Glucose 35-42 interferon gamma Homo sapiens 156-165 29526607-3 2018 DESIGN: This prospective, cross-sectional study used interferon-gamma release assay (IGRA) to screen for TB among Emirati citizens between August-2016 and May-2017; expatriates were not included in this study. Terbium 105-107 interferon gamma Homo sapiens 53-69 29211299-7 2018 The suppression on T cell proliferation and IFN-gamma production was reversed by ROS inhibitor and Arginase inhibitor. ros 81-84 interferon gamma Homo sapiens 44-53 29664018-7 2018 These results demonstrated that ICB increased vessel perfusion by promoting CD8+ T cell accumulation and IFN-gamma production, indicating that increased vessel perfusion reflects the successful activation of antitumor T cell immunity by ICB. indole-2-carboxylic acid 32-35 interferon gamma Homo sapiens 105-114 29494851-5 2018 Constitutive expression of IFN-gamma was higher in patients treated with dasatinib or with other TKIs than in those who were in treatment-free remission (TFR). Dasatinib 73-82 interferon gamma Homo sapiens 27-36 29703987-5 2018 Our study showed inhibition of the staphylococcal enterotoxins A and B (SEA and SEB) response by Th22 (CD4+IL-22+IL-17A-IFN-gamma-) cells in AD patients. th22 97-101 interferon gamma Homo sapiens 120-129 29796172-5 2018 TNF-alpha and IFN-gamma led to increased Stat1 phosphorylation through serine and tyrosine sites and a compensatory reduction in Stat3 activation. Serine 71-77 interferon gamma Homo sapiens 14-23 29796172-5 2018 TNF-alpha and IFN-gamma led to increased Stat1 phosphorylation through serine and tyrosine sites and a compensatory reduction in Stat3 activation. Tyrosine 82-90 interferon gamma Homo sapiens 14-23 29796172-6 2018 Single agent IFN-gamma enhanced Stat1 phosphorylation on tyrosine 701 and similar effects were observed in combination with TNF-alpha and EGFR inhibition. Tyrosine 57-65 interferon gamma Homo sapiens 13-22 29673285-7 2018 Addition of class A CpG oligonucleotide (ODN) to Th1 polarizing TLR agonist combinations significantly reduced cord blood IL-12p70 and IFN-gamma levels and addition of a TLR2 agonist induced significantly high Th2 polarizing IL-13. Oligonucleotides 24-39 interferon gamma Homo sapiens 135-144 29703987-6 2018 In contrast, Tc22 (CD8+IL-22+IL-17A-IFN-gamma-) cells were less susceptible to the inhibitory effects of staphylococcal enterotoxins and exhibited an enhanced response to the bacterial stimuli. tc22 13-17 interferon gamma Homo sapiens 36-45 29720976-5 2018 In contrast to CpG ODNs, CA nanoparticles containing CpG ODNs (designated CA-CpG) induced significant IFN-alpha production by mouse dendritic cells and human peripheral blood mononuclear cells in vitro; and production of interleukin-12, and IFN-gamma was higher in CA-CpG-treated groups than in CpG ODNs groups. ca-cpg 74-80 interferon gamma Homo sapiens 241-250 29779769-1 2018 This study aimed to determine whether there are seasonal changes in the performance of QuantiFERON-TB Gold In-Tube (QFT-GIT) assays, an interferon-gamma release assay widely used for the diagnosis of tuberculosis infection. Terbium 99-101 interferon gamma Homo sapiens 136-152 29549051-1 2018 To promote vascularization of tissue-engineered bone, IFN-gamma polarizing macrophages to M1 was loaded on 5% calcium silicate/beta-tricalcium phosphate (CaSiO3-beta-TCP) scaffolds. calcium silicate 110-126 interferon gamma Homo sapiens 54-63 29551681-0 2018 Interferon-gamma induces autophagy-associated apoptosis through induction of cPLA2-dependent mitochondrial ROS generation in colorectal cancer cells. Reactive Oxygen Species 107-110 interferon gamma Homo sapiens 0-16 29549051-1 2018 To promote vascularization of tissue-engineered bone, IFN-gamma polarizing macrophages to M1 was loaded on 5% calcium silicate/beta-tricalcium phosphate (CaSiO3-beta-TCP) scaffolds. beta-tricalcium phosphate 127-152 interferon gamma Homo sapiens 54-63 29549051-1 2018 To promote vascularization of tissue-engineered bone, IFN-gamma polarizing macrophages to M1 was loaded on 5% calcium silicate/beta-tricalcium phosphate (CaSiO3-beta-TCP) scaffolds. casio3-beta-tcp 154-169 interferon gamma Homo sapiens 54-63 29549051-3 2018 beta-TCP, CaSiO3-beta-TCP, and IFN-gamma@CaSiO3-beta-TCP were fabricated and biocompatibilities were evaluated. casio3-beta-tcp 41-56 interferon gamma Homo sapiens 31-40 29549051-7 2018 The results showed that IFN-gamma@CaSiO3-beta-TCP scaffolds released IFN-gamma in the early stage (1-3 days) to stimulate macrophages to M1 polarization, followed by release of Si inducing macrophages to M2 polarization while scaffolds degraded. N-(3,4,5-trichlorophenyl)succinimide 45-49 interferon gamma Homo sapiens 24-33 29551681-3 2018 We observed that IFN-gamma induced mitochondria-derived reactive oxygen species (ROS) production in a time-dependent manner in SW480 and HCT116 cell lines. Reactive Oxygen Species 56-79 interferon gamma Homo sapiens 17-26 29549051-7 2018 The results showed that IFN-gamma@CaSiO3-beta-TCP scaffolds released IFN-gamma in the early stage (1-3 days) to stimulate macrophages to M1 polarization, followed by release of Si inducing macrophages to M2 polarization while scaffolds degraded. N-(3,4,5-trichlorophenyl)succinimide 45-49 interferon gamma Homo sapiens 69-78 29551681-3 2018 We observed that IFN-gamma induced mitochondria-derived reactive oxygen species (ROS) production in a time-dependent manner in SW480 and HCT116 cell lines. Reactive Oxygen Species 81-84 interferon gamma Homo sapiens 17-26 29549051-9 2018 The IFN-gamma@CaSiO3-beta-TCP scaffolds formed more blood vessels in vitro and in vivo compared to the control groups. beta-tricalcium phosphate 21-29 interferon gamma Homo sapiens 4-13 29551681-4 2018 The IFN-gamma-induced mitochondrial ROS generation was dependent on the activation of cytosolic phospholipase A2 (cPLA2). Reactive Oxygen Species 36-39 interferon gamma Homo sapiens 4-13 29551681-5 2018 In addition, a mitochondria-targeted antioxidant SS31 and/or cPLA2 inhibitor AACOCF3 abolished the IFN-gamma-induced ROS production and subsequent autophagy and apoptosis. Reactive Oxygen Species 117-120 interferon gamma Homo sapiens 99-108 29551681-8 2018 Collectively, our results suggested that IFN-gamma induces autophagy-associated apoptosis in CRC cells via inducing cPLA2-dependent mitochondrial ROS production. Reactive Oxygen Species 146-149 interferon gamma Homo sapiens 41-50 29531163-4 2018 Our investigations revealed that anti-CD3/CD28-stimulated CD4+ T cells cultured in biotin-deficient medium secreted significantly enhanced levels of the proinflammatory cytokines IFN-gamma, TNF, and IL-17. Biotin 83-89 interferon gamma Homo sapiens 179-188 29850630-7 2018 Although Treg activation in the presence of DAC led to increased IFNgamma expression and induction of a Thelper-1 phenotype, the Treg maintained their suppressive capacity. Decitabine 44-47 interferon gamma Homo sapiens 65-73 29669281-4 2018 Interference of fatty acid synthesis in naive T cells dramatically upregulates IFN-gamma, while increasing exogenous lipids in media inhibits production of IFN-gamma by all subsets, suggesting that relative ratio of fatty acid metabolism to glycolysis is a direct predictor of T cell effector activity. Fatty Acids 16-26 interferon gamma Homo sapiens 79-88 29615049-11 2018 We found an increase in blood IFN-gamma (p = 0.02) and a trend to lower IL-5 levels in patients treated with SB010. sb010 109-114 interferon gamma Homo sapiens 30-39 29670629-5 2018 Levels of IFN-gamma secretion by Vgamma9/Vdelta2 T cells were profoundly increased by pAg loading, or by binding of the pan-BTN3A specific agonist antibody CD277 20.1, in HeLa-M compared to HeLa-L cells. pag 86-89 interferon gamma Homo sapiens 10-19 29621339-6 2018 CAM also improved survival in post-influenza, CAM-resistant pneumococcal pneumonia, with improved lung pathology as well as decreased interferon (IFN)-gamma and increased IL-10 levels. Clarithromycin 0-3 interferon gamma Homo sapiens 134-156 29622693-0 2018 Stratification by interferon-gamma release assay level predicts risk of incident TB. Terbium 81-83 interferon gamma Homo sapiens 18-34 29622693-5 2018 We used restricted cubic splines to model non-linear relationships between IFN-gamma levels and TB, and applied these findings to a competing risk model. Terbium 96-98 interferon gamma Homo sapiens 75-84 29622693-8 2018 TB risk increased with the IFN-gamma level until a plateau level, above which further increase was not associated with additional prognostic information. Terbium 0-2 interferon gamma Homo sapiens 27-36 29622693-9 2018 The HRs for TB were 8.8 (95% CI 4.7 to 16.5), 19.2 (95% CI 11.6 to 31.6) and 31.3 (95% CI 19.8 to 49.5) times higher with IFN-gamma levels of 0.35 to <1.00, 1.00 to <4.00 and >4.00 IU/mL, respectively, compared with negative tests (<0.35 IU/mL). Terbium 12-14 interferon gamma Homo sapiens 122-131 29356862-2 2018 HBCD and TBBPA have been shown to alter the tumor killing function of natural killer (NK) lymphocytes and the secretion of the inflammatory cytokines interferon gamma (IFNgamma) and interleukin 1 beta (IL-1beta). tetrabromobisphenol A 9-14 interferon gamma Homo sapiens 150-177 29606811-9 2018 Conclusion: The results of this study show IFN-gamma levels in the scales of alopecic patches might possibly reflect the clinical response in AA patients treated with DPCP. diphenylcyclopropenone 167-171 interferon gamma Homo sapiens 43-52 29617458-10 2018 Considering their lower capacity to produce TB-specific interferon-gamma, a lower cut-off level for defining QFT-Plus-positivity may be considered in HIV-positive pregnant women. Terbium 44-46 interferon gamma Homo sapiens 56-72 29380012-8 2018 DNCB and MBT increased a subset of IL-23 receptor+/IFN-gamma receptor 1 (CD119)+ lymphocytes. Dinitrochlorobenzene 0-4 interferon gamma Homo sapiens 51-60 29358174-6 2018 In particular, the expression of IFNgamma, NKG2D, and DNAM-1 were reduced upon LDL cholesterol treatment of phosphoantigen-expanded Vgamma9Vdelta2 T cells. Cholesterol 83-94 interferon gamma Homo sapiens 33-41 29543650-5 2018 Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme of the tryptophan catabolite (TRYCAT) pathway, is induced by interferon-gamma, interleukin-6, TNF-alpha, and oxidative stress. tryptophan catabolite 67-88 interferon gamma Homo sapiens 121-137 29358174-6 2018 In particular, the expression of IFNgamma, NKG2D, and DNAM-1 were reduced upon LDL cholesterol treatment of phosphoantigen-expanded Vgamma9Vdelta2 T cells. phosphoantigen 108-122 interferon gamma Homo sapiens 33-41 29420357-6 2018 On reexamination, previously drug-naive AD patients who received donepezil treatment for 6 months displayed a decrease in cell-derived IFN-gamma, TNF-alpha, IL-1beta, and IL-6. Donepezil 65-74 interferon gamma Homo sapiens 135-144 29463472-5 2018 Adenosine triphosphate (ATP) distributed by aerobic glycolysis is critical for sustaining IFN-gamma triggered JAK (Janus tyrosine kinase)-STAT-1 (Signal Transducer and Activator of Transcription 1) signaling with phosphorylation of the transcription factor STAT-1 as its signature trait. Adenosine Triphosphate 0-22 interferon gamma Homo sapiens 90-99 29463472-5 2018 Adenosine triphosphate (ATP) distributed by aerobic glycolysis is critical for sustaining IFN-gamma triggered JAK (Janus tyrosine kinase)-STAT-1 (Signal Transducer and Activator of Transcription 1) signaling with phosphorylation of the transcription factor STAT-1 as its signature trait. Adenosine Triphosphate 24-27 interferon gamma Homo sapiens 90-99 29397417-4 2018 The terminal ileum IFN-gamma, IL-6, and IL-1beta were elevated in CD-new, while in the colon, the IFN-gamma, IL-17A, and IL-6 were elevated in both CD-new and CD-treated subgroups. cd-new 66-72 interferon gamma Homo sapiens 19-28 29432913-8 2018 Administration of fluconazole significantly stimulated eosinophils population and secretion of inflammatory cytokines IFN-gamma and TNF-alpha. Fluconazole 18-29 interferon gamma Homo sapiens 118-127 29273450-9 2018 Cells infected with H pylori were depleted of cholesterol, which reduced IFNG signaling by disrupting lipid rafts, leading to reduced phosphorylation (activation) of JAK and STAT1. Cholesterol 46-57 interferon gamma Homo sapiens 73-77 29273450-15 2018 CONCLUSIONS: H pylori expression of cgt reduces cholesterol levels in infected gastric epithelial cells and thereby blocks IFNG signaling, allowing the bacteria to escape the host inflammatory response. Cholesterol 48-59 interferon gamma Homo sapiens 123-127 29350834-4 2018 Pantoprazole stimulation additionally reduced the production of the proinflammatory cytokine IL-1beta in whole blood assay as well as the production of IL-2 and IFN-gamma after whole blood stimulation with phytohaemagglutinin. Pantoprazole 0-12 interferon gamma Homo sapiens 161-170 29380034-7 2018 In the lungs, prior bethanechol treatment increased transcripts for IFNgamma and its downstream target CXCL10. Bethanechol 20-31 interferon gamma Homo sapiens 68-76 29552182-10 2018 IFN-gamma levels in the supernatant of ascites-derived TILs were increased by As2O3, whereas IL-10 and TGF-beta levels were significantly reduced (P<0.05). Arsenic Trioxide 78-83 interferon gamma Homo sapiens 0-9 28691653-7 2018 rLdiPGAM induced remarkable Lymphoproliferative response and NO production in treated Leishmania-infected hamsters as well as in patients and increase in interferon gamma (IFN-gamma), interleukin-12 (IL-12p40) responses in Leishmania patients in clinical remission. rldipgam 0-8 interferon gamma Homo sapiens 154-181 29584690-10 2018 Furthermore, levels of mRNA expression and secretion of IFN-gamma (interferon gamma) increased in KHYG-1 cells that had been treated with the six lactic acid bacteria mixture from kefir. Lactic Acid 146-157 interferon gamma Homo sapiens 56-65 29584690-10 2018 Furthermore, levels of mRNA expression and secretion of IFN-gamma (interferon gamma) increased in KHYG-1 cells that had been treated with the six lactic acid bacteria mixture from kefir. Lactic Acid 146-157 interferon gamma Homo sapiens 67-83 29140933-1 2018 BACKGROUND: The T-SPOT.TB, an interferon-gamma release assay, is an indirect test of Mycobacterium tuberculosis infection. Terbium 23-25 interferon gamma Homo sapiens 30-46 29747740-6 2018 The IFN-gamma gene expression index, IFN-gamma/IL-4 and IL-10/IL-4 gene expression ratio were significantly increased due to the high concentration (90 microM) of auraptene treatment compared to control group (P < 0.05-0.001). aurapten 163-172 interferon gamma Homo sapiens 4-13 29747740-6 2018 The IFN-gamma gene expression index, IFN-gamma/IL-4 and IL-10/IL-4 gene expression ratio were significantly increased due to the high concentration (90 microM) of auraptene treatment compared to control group (P < 0.05-0.001). aurapten 163-172 interferon gamma Homo sapiens 37-46 29747740-8 2018 Gene expression of IL-10 and IL-4 was decreased but that of IFN-gamma as well as FN-gamma/IL-4 and IL-10/IL-4 ratio were significantly increased due to all three concentrations of auraptene. aurapten 180-189 interferon gamma Homo sapiens 60-69 29747740-9 2018 CONCLUSION: The results showed promoting effects of auraptene on T cell subsets toward Th1 (IFN-gamma) and Treg (IL-10), which suggest its therapeutic value for treatment of Th2 cells predominant diseases including allergic disease such as asthma and atopic dermatitis as well as cancers. aurapten 52-61 interferon gamma Homo sapiens 92-101 29596409-9 2018 IFN-gamma/IL-10 ratio and CRP values marked the immune biosignature of vivax malaria patients, and could distinguish subjects with elevated creatinine levels who did not survive from those who did. Creatinine 140-150 interferon gamma Homo sapiens 0-9 29317357-6 2018 Furthermore, known mechanisms of the adjuvant activity of Al(OH)3 were elucidated in more detail such as inflammasome and complement activation, homeostasis and HLA-class II upregulation, possibly related to increased IFNgamma gene expression. Aluminum Hydroxide 58-65 interferon gamma Homo sapiens 218-226 29352647-0 2018 IFN-gamma and TNF-alpha Pre-licensing Protects Mesenchymal Stromal Cells from the Pro-inflammatory Effects of Palmitate. Palmitates 110-119 interferon gamma Homo sapiens 0-9 29523440-5 2018 Glucose tracing pinpointed pyruvate oxidation in mitochondria, which was the metabolic requirement for rapid generation of interferon-gamma (IFN-gamma) in memory T cells. Glucose 0-7 interferon gamma Homo sapiens 123-139 29523440-5 2018 Glucose tracing pinpointed pyruvate oxidation in mitochondria, which was the metabolic requirement for rapid generation of interferon-gamma (IFN-gamma) in memory T cells. Glucose 0-7 interferon gamma Homo sapiens 141-150 29523440-5 2018 Glucose tracing pinpointed pyruvate oxidation in mitochondria, which was the metabolic requirement for rapid generation of interferon-gamma (IFN-gamma) in memory T cells. Pyruvic Acid 27-35 interferon gamma Homo sapiens 123-139 29523440-5 2018 Glucose tracing pinpointed pyruvate oxidation in mitochondria, which was the metabolic requirement for rapid generation of interferon-gamma (IFN-gamma) in memory T cells. Pyruvic Acid 27-35 interferon gamma Homo sapiens 141-150 29436216-3 2018 In our study, TNF-alpha and IFN-gamma were coimmobilized on polystyrene material (PSt) or Fe3O4-oleic acid nanoparticles (NPs). Polystyrenes 60-71 interferon gamma Homo sapiens 28-37 29436216-3 2018 In our study, TNF-alpha and IFN-gamma were coimmobilized on polystyrene material (PSt) or Fe3O4-oleic acid nanoparticles (NPs). ferryl iron 90-95 interferon gamma Homo sapiens 28-37 29436216-3 2018 In our study, TNF-alpha and IFN-gamma were coimmobilized on polystyrene material (PSt) or Fe3O4-oleic acid nanoparticles (NPs). Oleic Acid 96-106 interferon gamma Homo sapiens 28-37 29872557-7 2018 In the presence of DCs, chitosan augmented IFN-gamma production by human NK cells. Chitosan 24-32 interferon gamma Homo sapiens 43-52 29363446-12 2018 We conclude that TVDV was safe and well-tolerated and elicited predominately anti-dengue T-cell IFNgamma responses in a dose-related fashion. tvdv 17-21 interferon gamma Homo sapiens 96-104 29582861-0 2018 Erratum: Author Correction: Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNgamma response promoting vaccine immunogenicity. as01 62-66 interferon gamma Homo sapiens 107-115 29424635-6 2018 BBD and ANN-GA, both optimization techniques predicted a higher lactose concentration was clearly beneficial for augmenting K. lactis biomass which in turn increased hIFN-gamma concentration. Lactose 64-71 interferon gamma Homo sapiens 166-176 29525808-13 2018 Interestingly, carbon irradiation triggered a burst of IFN-g and IL-12 in LPS or CpG treated DCs, which provide novel insights into the combination of immunotherapy and carbon ion radiotherapy. Carbon 15-21 interferon gamma Homo sapiens 55-60 29525808-13 2018 Interestingly, carbon irradiation triggered a burst of IFN-g and IL-12 in LPS or CpG treated DCs, which provide novel insights into the combination of immunotherapy and carbon ion radiotherapy. Carbon 169-175 interferon gamma Homo sapiens 55-60 29515027-9 2018 We conclude that immunosuppressive properties of human PCs are not intrinsic but instead result from IFN-gamma-induced IDO1-mediated tryptophan depletion. Tryptophan 133-143 interferon gamma Homo sapiens 101-110 29352647-5 2018 The pro-inflammatory effect of MSCs in palmitate was partially reversed via palmitate removal and fully reversed through pre-licensing MSCs with interferon-gamma and tumor necrosis factor alpha. Palmitates 39-48 interferon gamma Homo sapiens 145-193 29409936-4 2018 Interestingly, DNA-demethylating 5-aza-2"-deoxycytidine enhanced IFNgamma-induced IL-18BP only in monocytic but not in epithelial cells. Decitabine 33-55 interferon gamma Homo sapiens 65-73 29218605-0 2018 Oxymatrine Sensitizes the HaCaT Cells to the IFN-gamma Pathway and Downregulates MDC, ICAM-1, and SOCS1 by Activating p38, JNK, and Akt. oxymatrine 0-10 interferon gamma Homo sapiens 45-54 29139169-7 2018 Palmitic acid did not affect basal migration or phagocytosis, but abolished the migration and phagocytic activity of male and female microglia in response to interferon-gamma. Palmitic Acid 0-13 interferon gamma Homo sapiens 158-174 29232759-10 2018 Inhibition of CYP1B1 with the selective inhibitor 2,4,3",5"-tetramethoxystilbene (100 nM) partly reverses the effects of IFNgamma on epithelial permeability. 2,4,3',5'-tetramethoxystilbene 50-80 interferon gamma Homo sapiens 121-129 29402391-3 2018 Thus we wondered whether IFN-gamma would counteract tumor ganglioside-mediated immune suppression. Gangliosides 58-69 interferon gamma Homo sapiens 25-34 29066221-1 2018 1,25-dihydroxyvitaminD3 (1,25(OH)2D3), has potent anti-inflammatory effects, including suppression of IL-17 + and IFNgamma+ T cells implicated in rheumatoid arthritis (RA), but efficacy at the site of active disease is unclear. 1,25-dihydroxyvitamind3 (1,25(oh)2d3 0-36 interferon gamma Homo sapiens 114-122 29066221-6 2018 Further studies using stimulated CD4+ T cells sorted according to IL-17 and IFNgamma expression confirmed the ability of 1,25(OH)2D3 to suppress pre-existing cytokines. Calcitriol 121-132 interferon gamma Homo sapiens 76-84 29066221-7 2018 However, 1,25(OH)2D3 was most effective at suppressing de novo IL-17 and IFNgamma induction. Calcitriol 9-20 interferon gamma Homo sapiens 73-81 29235391-0 2018 Association between vitamin D, oestradiol and interferon-gamma in female patients with inactive systemic lupus erythematosus: A cross-sectional study. Vitamin D 20-29 interferon gamma Homo sapiens 46-62 30364570-8 2018 We demonstrate that IFN-gamma induces expression of numerous immunosuppressive proteins (IDO, PD-L1, HLA-E, HLA-G), whereas hypoxia switches MSCs to glycolysis, causing rapid glucose consumption and production of T-cell inhibitory lactate levels. Glucose 175-182 interferon gamma Homo sapiens 20-29 30364570-8 2018 We demonstrate that IFN-gamma induces expression of numerous immunosuppressive proteins (IDO, PD-L1, HLA-E, HLA-G), whereas hypoxia switches MSCs to glycolysis, causing rapid glucose consumption and production of T-cell inhibitory lactate levels. Lactic Acid 231-238 interferon gamma Homo sapiens 20-29 29275476-0 2018 Lignosulfonic acid attenuates NF-kappaB activation and intestinal epithelial barrier dysfunction induced by TNF-alpha/IFN-gamma in Caco-2 cells. LIGNOSULFONIC ACID 0-18 interferon gamma Homo sapiens 118-127 29275476-6 2018 Lignosulfonic acid also attenuated the barrier dysfunction that is caused by tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma in Caco-2 cells. LIGNOSULFONIC ACID 0-18 interferon gamma Homo sapiens 115-137 29275476-7 2018 TNF-alpha- and IFN-gamma-induced activation of NF-kappaB, such as translocation of NF-kappaB p65 into the nucleus and induction of gene expression, was inhibited by lignosulfonic acid treatment. LIGNOSULFONIC ACID 165-183 interferon gamma Homo sapiens 15-24 29275476-8 2018 Furthermore, lignosulfonic acid decreased the TNF-alpha- and IFN-gamma-induced increase in interleukin (IL)-1beta and IL-6 expression in Caco-2 cells. LIGNOSULFONIC ACID 13-31 interferon gamma Homo sapiens 61-70 29235391-0 2018 Association between vitamin D, oestradiol and interferon-gamma in female patients with inactive systemic lupus erythematosus: A cross-sectional study. Estradiol 31-41 interferon gamma Homo sapiens 46-62 29235391-1 2018 Objectives To investigate possible associations between 25-hydroxyvitamin D3 (25(OH)D3), oestradiol (E2) and IFN-gamma (IFNgamma) in female patients with inactive systemic lupus erythematosus (SLE). Calcifediol 56-76 interferon gamma Homo sapiens 120-128 29235391-1 2018 Objectives To investigate possible associations between 25-hydroxyvitamin D3 (25(OH)D3), oestradiol (E2) and IFN-gamma (IFNgamma) in female patients with inactive systemic lupus erythematosus (SLE). Estradiol 89-99 interferon gamma Homo sapiens 109-118 29235391-1 2018 Objectives To investigate possible associations between 25-hydroxyvitamin D3 (25(OH)D3), oestradiol (E2) and IFN-gamma (IFNgamma) in female patients with inactive systemic lupus erythematosus (SLE). Estradiol 89-99 interferon gamma Homo sapiens 120-128 29235391-1 2018 Objectives To investigate possible associations between 25-hydroxyvitamin D3 (25(OH)D3), oestradiol (E2) and IFN-gamma (IFNgamma) in female patients with inactive systemic lupus erythematosus (SLE). Estradiol 101-103 interferon gamma Homo sapiens 109-118 29235391-6 2018 In vitamin D deficient (i.e., 25(OH)D3<=20 ng/ml) patients, IFNgamma was 150% higher compared with patients with 25(OH)D3>20 ng/ml and controls. Vitamin D 3-12 interferon gamma Homo sapiens 63-71 29235391-6 2018 In vitamin D deficient (i.e., 25(OH)D3<=20 ng/ml) patients, IFNgamma was 150% higher compared with patients with 25(OH)D3>20 ng/ml and controls. 25(oh)d3< 30-41 interferon gamma Homo sapiens 63-71 29235391-6 2018 In vitamin D deficient (i.e., 25(OH)D3<=20 ng/ml) patients, IFNgamma was 150% higher compared with patients with 25(OH)D3>20 ng/ml and controls. 25(oh)d3> 116-127 interferon gamma Homo sapiens 63-71 29229189-9 2018 The infiltration of T cells, B cells and macrophages as well as interferon-gamma, interleukin-17, IgG and complement deposition were reduced in renal allografts of ONX 0914-treated recipients. PR-957 164-172 interferon gamma Homo sapiens 64-80 29286163-9 2018 Staining of IFN-gamma in paraffin-embedded samples was positive in 92.6% (25/27) of specimens in which Aspergillus spp were the causative pathogen, which was significantly higher compared with specimens in which Mucorales was causative (P<0.001), with only 4.2% (1/24) of specimens staining positive for IFN-gamma. Paraffin 25-33 interferon gamma Homo sapiens 12-21 28736298-7 2018 Using TL-1 cells, IFN-gamma decreased starting at 4h following calcitriol treatment, with a reduction in the intracellular and secreted protein levels as well as the mRNA content. Calcitriol 63-73 interferon gamma Homo sapiens 18-27 28736298-13 2018 Calcitriol treatment upregulated VDR and decreased IFN-gamma regardless of initial VDR knockdown efficiency, strengthening the connection between VDR upregulation and IFN-gamma reduction. Calcitriol 0-10 interferon gamma Homo sapiens 51-60 28736298-13 2018 Calcitriol treatment upregulated VDR and decreased IFN-gamma regardless of initial VDR knockdown efficiency, strengthening the connection between VDR upregulation and IFN-gamma reduction. Calcitriol 0-10 interferon gamma Homo sapiens 167-176 28343296-9 2018 While cypermethrin increased the expression of interleukin-1beta, interleukin-4, interferon-gamma, inducible nitric oxide synthase, caspase-3, caspase-9 and B-cell lymphoma (Bcl)-xl proteins, it attenuated Bcl-2 expression. cypermethrin 6-18 interferon gamma Homo sapiens 81-97 28736298-0 2018 Calcitriol-mediated reduction in IFN-gamma output in T cell large granular lymphocytic leukemia requires vitamin D receptor upregulation. Calcitriol 0-10 interferon gamma Homo sapiens 33-42 28736298-3 2018 In canonical IFN-gamma-STAT1 signaling, IFN-gamma activates STAT1, a transcription factor, via phosphorylation of tyrosine residue 701 (p-STAT1). Tyrosine 114-122 interferon gamma Homo sapiens 13-22 28736298-3 2018 In canonical IFN-gamma-STAT1 signaling, IFN-gamma activates STAT1, a transcription factor, via phosphorylation of tyrosine residue 701 (p-STAT1). Tyrosine 114-122 interferon gamma Homo sapiens 40-49 28736298-5 2018 We previously found that calcitriol treatment of the TL-1 cell line, a model of T-LGLL, significantly decreased IFN-gamma secretion and p-STAT1 while increasing the vitamin D receptor (VDR) protein. Calcitriol 25-35 interferon gamma Homo sapiens 112-121 29228301-11 2018 Correspondingly, IFNgamma-induced FAK activation and invasion of FLS was abrogated by the JAK inhibitor, baricitinib. baricitinib 105-116 interferon gamma Homo sapiens 17-25 29431743-4 2018 Sorafenib-related IL-15 production caused an increase in CD8+CD107a+IFN-gamma+ T cells with features of longevity (high levels of Bcl-2 and reduced PD-1 levels), which eradicated leukemia in secondary recipients. Sorafenib 0-9 interferon gamma Homo sapiens 68-77 29155016-3 2018 In this report, we demonstrated that in vitro, DZ2002 significantly decreased the expression of pro-inflammatory cytokines and adhesion molecule including IL-1alpha, IL-1beta, IL-6, IL-8, TNF-alpha and ICAM-1 by inhibiting the phosphorylation of p38 MAPK, ERK and JNK in TNF-alpha/IFN-gamma-stimulated HaCaT human keratinocytes. methyl 4-(adenin-9-yl)-2-hydroxybutanoate 47-53 interferon gamma Homo sapiens 281-290 29308890-2 2018 The aptasensor consists of an IFN-gamma aptamer labeled with a fluorogen with a typical aggregation-induced emission (AIE) characteristic, which shows strong red emission only in the presence of IFN-gamma. fluorogen 63-72 interferon gamma Homo sapiens 30-39 29308890-2 2018 The aptasensor consists of an IFN-gamma aptamer labeled with a fluorogen with a typical aggregation-induced emission (AIE) characteristic, which shows strong red emission only in the presence of IFN-gamma. fluorogen 63-72 interferon gamma Homo sapiens 195-204 29424668-3 2018 In the present study, recombinant human interferon gamma (IFNG) was expressed for the first time in Kluyveromyces lactis expression system and its expression was optimized by varying growth parameters and carbon source concentration with the aim of increasing recombinant protein production level. Carbon 205-211 interferon gamma Homo sapiens 40-63 29515464-6 2018 Myoblasts were exposed to DMEM solutions enriched with pro-inflammatory cytokines IFN-gamma with IL-1beta or hyperosmolar DMEM obtained by NaCl supplementation. dmem 26-30 interferon gamma Homo sapiens 82-91 29466421-7 2018 The IFN-gamma level was elevated in 10mg/kg/d resveratrol-treated group and 30mg/kg/d resveratrol-treated group after RV infection. Resveratrol 46-57 interferon gamma Homo sapiens 4-13 29466421-7 2018 The IFN-gamma level was elevated in 10mg/kg/d resveratrol-treated group and 30mg/kg/d resveratrol-treated group after RV infection. Resveratrol 86-97 interferon gamma Homo sapiens 4-13 29479352-5 2018 We investigated the effect of prednisolone treatment on the inflammatory cytokines TNF, IFN-gamma, IL-1beta, IL-6, and IL-17 and the regulatory cytokines IL-10 and TGF-beta in the skin lesion and blood of patients with ENL and compared with non-reactional LL patient controls. Prednisolone 30-42 interferon gamma Homo sapiens 88-97 29235156-10 2018 The study shows that IFN-gamma against the 38 kDa discriminates clinical TB from infection and infection from exposure, suggesting its potential for immune protection and diagnosis. Terbium 73-75 interferon gamma Homo sapiens 21-30 29467761-0 2018 Establishment of the Reference Intervals of Lymphocyte Function in Healthy Adults Based on IFN-gamma Secretion Assay upon Phorbol-12-Myristate-13-Acetate/Ionomycin Stimulation. Tetradecanoylphorbol Acetate 122-153 interferon gamma Homo sapiens 91-100 29467761-0 2018 Establishment of the Reference Intervals of Lymphocyte Function in Healthy Adults Based on IFN-gamma Secretion Assay upon Phorbol-12-Myristate-13-Acetate/Ionomycin Stimulation. Ionomycin 154-163 interferon gamma Homo sapiens 91-100 29456507-5 2018 Results: Results of RT-PCR indicated that after the 12-week intervention, compared to the placebo, vitamin D supplementation downregulated gene expression of interleukin (IL)-1beta (P = 0.02), tumor necrosis factor alpha (TNF-alpha) (P = 0.02) and interferon gamma (IFN-gamma) (P = 0.03) in PBMCs of diabetic HD patients. Vitamin D 99-108 interferon gamma Homo sapiens 248-275 28969431-5 2018 After three HIV-DNA immunizations, IFN-gamma ELISpot responses to Gag were detected in 9/17 (53%) vaccinees, while none responded to Envelope (Env). Glycosaminoglycans 66-69 interferon gamma Homo sapiens 35-44 29128569-10 2018 Treatment of Caco-2 cells with tumor necrosis factor-alpha and interferon-gamma significantly increased paracellular permeability, which was blocked by cotreatment with LPA, but not LPA1 knockdown cells. lysophosphatidic acid 169-172 interferon gamma Homo sapiens 63-79 28730424-7 2018 After retinol stimulation, the concentration of IL-17 and IFN-gamma increased significantly in both groups. Vitamin A 6-13 interferon gamma Homo sapiens 58-67 29198726-4 2018 Increased neopterin was detected in human nerve cells supernatants (highest secretion in astrocytes) exposed to lipopolysaccharide (LPS) and interferon-gamma (INF-gamma) and in the hippocampus of mice receiving LPS (0.33mg/kg; intraperitoneal). Neopterin 10-19 interferon gamma Homo sapiens 141-168 28694201-0 2018 Use of QuantiFERON-TB Gold In-tube assay in screening for neutralizing anti-interferon-gamma autoantibodies in patients with disseminated nontuberculous mycobacterial infection. tb gold 19-26 interferon gamma Homo sapiens 76-92 28694201-1 2018 OBJECTIVE: Anti-interferon- gamma (IFN-gamma) autoantibodies (anti-IFN-gamma Abs) have been increasingly recognized as an important cause of disseminated nontuberculous mycobacterial (DNTM) infection, and identification of this immunodeficiency impacts clinical management. dntm 184-188 interferon gamma Homo sapiens 11-33 28694201-1 2018 OBJECTIVE: Anti-interferon- gamma (IFN-gamma) autoantibodies (anti-IFN-gamma Abs) have been increasingly recognized as an important cause of disseminated nontuberculous mycobacterial (DNTM) infection, and identification of this immunodeficiency impacts clinical management. dntm 184-188 interferon gamma Homo sapiens 35-44 28694201-1 2018 OBJECTIVE: Anti-interferon- gamma (IFN-gamma) autoantibodies (anti-IFN-gamma Abs) have been increasingly recognized as an important cause of disseminated nontuberculous mycobacterial (DNTM) infection, and identification of this immunodeficiency impacts clinical management. dntm 184-188 interferon gamma Homo sapiens 67-76 28694201-3 2018 Here, we sought to determine whether QuantiFERON-TB Gold In-tube (QFT-GIT), a commercialized IFN-gamma release assay, could be used to screen for neutralizing anti-IFN-gamma Abs among previously healthy adults with DNTM infection. tb gold 49-56 interferon gamma Homo sapiens 164-173 28694201-9 2018 CONCLUSION: An indeterminate QFT-GIT result because of undetectable or extremely low IFN-gamma level in the mitogen tube suggests the presence of neutralizing anti-IFN-gamma Abs in a previously healthy patient with DNTM infection. dntm 215-219 interferon gamma Homo sapiens 85-94 28694201-9 2018 CONCLUSION: An indeterminate QFT-GIT result because of undetectable or extremely low IFN-gamma level in the mitogen tube suggests the presence of neutralizing anti-IFN-gamma Abs in a previously healthy patient with DNTM infection. dntm 215-219 interferon gamma Homo sapiens 164-173 29061519-0 2018 A novel reverse micellar purification strategy for histidine tagged human interferon gamma (hIFN-gamma) protein from Pichia pastoris. Histidine 51-60 interferon gamma Homo sapiens 74-102 29185091-9 2018 After stimulation with 50 IU/ml IFNgamma, Fas:Fc significantly increased MCF7 apoptosis (1.39 +- 0.06-fold, p = 0.0004) after 18 h. After stimulation with 100 IU/ml, Fas:Fc significantly increased apoptosis both after 4 h (1.49 +- 0.15-fold, p = 0.018) and 18 h (1.30 +- 0.06-fold, p = 0.013). ammonium ferrous sulfate 166-169 interferon gamma Homo sapiens 32-40 28919446-4 2018 The results show that in vitro treatment with Modafinil increased Interferon (IFN)-gamma, Interleukin (IL)-2 and IL-17 production and CD25 expression by T cells. Modafinil 46-55 interferon gamma Homo sapiens 66-88 28919446-5 2018 In turn, in vivo Modafinil treatment enhanced splenocyte production of IFN-gamma, IL-6 and tumor necrosis factor (TNF), and increased the number of IFN-gamma producing cells. Modafinil 17-26 interferon gamma Homo sapiens 71-80 28919446-5 2018 In turn, in vivo Modafinil treatment enhanced splenocyte production of IFN-gamma, IL-6 and tumor necrosis factor (TNF), and increased the number of IFN-gamma producing cells. Modafinil 17-26 interferon gamma Homo sapiens 148-157 28919446-7 2018 We reported increased number of IFN-gamma producing cells in PBMCs from Narcolepsy type 1 patients following continuous Modafinil treatment, corroborating our animal data. Modafinil 120-129 interferon gamma Homo sapiens 32-41 29185091-9 2018 After stimulation with 50 IU/ml IFNgamma, Fas:Fc significantly increased MCF7 apoptosis (1.39 +- 0.06-fold, p = 0.0004) after 18 h. After stimulation with 100 IU/ml, Fas:Fc significantly increased apoptosis both after 4 h (1.49 +- 0.15-fold, p = 0.018) and 18 h (1.30 +- 0.06-fold, p = 0.013). ammonium ferrous sulfate 42-45 interferon gamma Homo sapiens 32-40 28731226-10 2018 The data of the in vitro experiments showed that curcumin converted the LC patient-isolated Tregs to Th1 cells via repressing the gene transcription of forkhead protein-3 and increasing the expression of interferon-gamma. Curcumin 49-57 interferon gamma Homo sapiens 204-220 29207093-11 2018 By contrast, HSS extract treatment inhibited TNF-alpha- and IFN-gamma-induced STAT1 activation. hepatic stimulator substance 13-16 interferon gamma Homo sapiens 60-69 28656526-10 2018 N-acetyl-L-cysteine reduced proliferation and IFNgamma in GO, and HA and IL1beta in both GO and control fibroblasts. Acetylcysteine 0-19 interferon gamma Homo sapiens 46-54 29425536-12 2018 Secretion of IFNg was also increased when particles were added to the cells as early as 1h. Hydrogen 88-90 interferon gamma Homo sapiens 13-17 28600879-5 2018 IFN-gamma priming provoked ROS elevation, cell growth slowdown, attenuation of both spontaneous and induced osteodifferentiation of tissue O2 -adapted ASCs. ros 27-30 interferon gamma Homo sapiens 0-9 28600879-5 2018 IFN-gamma priming provoked ROS elevation, cell growth slowdown, attenuation of both spontaneous and induced osteodifferentiation of tissue O2 -adapted ASCs. Oxygen 139-141 interferon gamma Homo sapiens 0-9 29207093-12 2018 Results from the present study indicated that HSS exhibited inhibitory effects on TNF-alpha- and IFN-gamma-mediated chemokine production and expression by targeting STAT1 in keratinocytes. hepatic stimulator substance 46-49 interferon gamma Homo sapiens 97-106 29031483-8 2018 Effects on DUOX2 were less dramatic, except that vanadate potentiated the stimulation by IFNgamma up to 7 fold. Vanadates 49-57 interferon gamma Homo sapiens 89-97 29434915-7 2018 In general, CD73 on the tumor cell membrane converts adenosine monophosphate to adenosine, which restrains the production of interferon-gamma and cytocidal activity. Adenosine Monophosphate 53-76 interferon gamma Homo sapiens 125-141 29434915-7 2018 In general, CD73 on the tumor cell membrane converts adenosine monophosphate to adenosine, which restrains the production of interferon-gamma and cytocidal activity. Adenosine 53-62 interferon gamma Homo sapiens 125-141 29136358-0 2018 Is secretion of IFN-gamma in response to Mycobacterium tuberculosis antigens in youngest children sufficient to play a role in TB diagnostics? Terbium 127-129 interferon gamma Homo sapiens 16-25 29136358-2 2018 WORKING HYPOTHESIS: Is TB-antigen-induced IFN-gamma response in children <=5 years sufficient to consider QFT-GIT a possible tool for TB diagnostics? Terbium 23-25 interferon gamma Homo sapiens 42-51 29136358-6 2018 In the mitogen tubes, the median IFN-gamma level was higher in children >5 years (median 17.87, IQR:2.1 vs 16.77, IQR:7.6), but surprisingly in the TB antigen tubes it was higher in the younger group (median 0.12, IQR:0.21vs 0.06, IQR:0.09, P = 0.04). Terbium 151-153 interferon gamma Homo sapiens 33-42 29136358-9 2018 CONCLUSIONS: The youngest children release sufficient amount of IFN-gamma in response to TB antigens thus QFT-GIT might be a useful tool for TB diagnostics in this age group. Terbium 89-91 interferon gamma Homo sapiens 64-73 29136358-9 2018 CONCLUSIONS: The youngest children release sufficient amount of IFN-gamma in response to TB antigens thus QFT-GIT might be a useful tool for TB diagnostics in this age group. Terbium 141-143 interferon gamma Homo sapiens 64-73 29074605-5 2018 Upon recognition of AML cells, DNTs rapidly release IFNgamma, which further increases NKG2D and DNAM-1 ligands" expression on AML cells. 2,6-dinitrotoluene 31-35 interferon gamma Homo sapiens 52-60 29403472-5 2017 Accordingly, rIL-23-induced NK cell activation and stimulated IFN-gamma production by CD56bright NK cells. ril-23 13-19 interferon gamma Homo sapiens 62-71 29339738-4 2018 Treatment of breast cancer cell lines with a next-generation hypomethylating agent, guadecitabine, upregulates MHC-I expression in response to interferon-gamma. guadecitabine 84-97 interferon gamma Homo sapiens 143-159 28970155-5 2018 RESULTS: PHE inhibited activation of p38, ERK, and JNK and suppressed the phosphorylation of STAT-1 and NK-kappaB in TNF-alpha/IFN-gamma-stimulated HaCaT cells. Phenylalanine 9-12 interferon gamma Homo sapiens 127-136 28970155-6 2018 PHE also suppressed chemokine mRNA and protein levels in TNF-alpha/IFN-gamma-stimulated HaCaT cells. Phenylalanine 0-3 interferon gamma Homo sapiens 67-76 28970155-8 2018 CONCLUSIONS: PHE suppresses the expression and production of TNF-alpha/IFN-gamma-stimulated proinflammatory chemokines by blocking NF-kappaB, STAT-1, and MAPK activation. Phenylalanine 13-16 interferon gamma Homo sapiens 71-80 29290477-13 2018 Significant upregulation of CD4, CD8, perforin, and IFNgamma expression were observed in the bursa samples 7 days postinoculation (dpi). 3-aminodiphenyleneiodium 131-134 interferon gamma Homo sapiens 52-60 29074605-6 2018 IFNgamma pretreatment enhances the susceptibility of AML cells to DNT-mediated cytotoxicity, including primary AML samples that are otherwise resistant to DNTs, and the effect of IFNgamma treatment is abrogated by NKG2D and DNAM-1-blocking antibodies.Conclusions: This study supports healthy donor-derived allogeneic DNTs as a therapy to treat patients with chemotherapy-resistant AML and also reveals interrelated roles of NKG2D, DNAM-1, and IFNgamma in selective targeting of AML by DNTs. 2,6-dinitrotoluene 155-159 interferon gamma Homo sapiens 0-8 29074605-6 2018 IFNgamma pretreatment enhances the susceptibility of AML cells to DNT-mediated cytotoxicity, including primary AML samples that are otherwise resistant to DNTs, and the effect of IFNgamma treatment is abrogated by NKG2D and DNAM-1-blocking antibodies.Conclusions: This study supports healthy donor-derived allogeneic DNTs as a therapy to treat patients with chemotherapy-resistant AML and also reveals interrelated roles of NKG2D, DNAM-1, and IFNgamma in selective targeting of AML by DNTs. 2,6-dinitrotoluene 317-321 interferon gamma Homo sapiens 0-8 29074605-6 2018 IFNgamma pretreatment enhances the susceptibility of AML cells to DNT-mediated cytotoxicity, including primary AML samples that are otherwise resistant to DNTs, and the effect of IFNgamma treatment is abrogated by NKG2D and DNAM-1-blocking antibodies.Conclusions: This study supports healthy donor-derived allogeneic DNTs as a therapy to treat patients with chemotherapy-resistant AML and also reveals interrelated roles of NKG2D, DNAM-1, and IFNgamma in selective targeting of AML by DNTs. 2,6-dinitrotoluene 317-321 interferon gamma Homo sapiens 179-187 29074605-6 2018 IFNgamma pretreatment enhances the susceptibility of AML cells to DNT-mediated cytotoxicity, including primary AML samples that are otherwise resistant to DNTs, and the effect of IFNgamma treatment is abrogated by NKG2D and DNAM-1-blocking antibodies.Conclusions: This study supports healthy donor-derived allogeneic DNTs as a therapy to treat patients with chemotherapy-resistant AML and also reveals interrelated roles of NKG2D, DNAM-1, and IFNgamma in selective targeting of AML by DNTs. 2,6-dinitrotoluene 317-321 interferon gamma Homo sapiens 179-187 29074605-6 2018 IFNgamma pretreatment enhances the susceptibility of AML cells to DNT-mediated cytotoxicity, including primary AML samples that are otherwise resistant to DNTs, and the effect of IFNgamma treatment is abrogated by NKG2D and DNAM-1-blocking antibodies.Conclusions: This study supports healthy donor-derived allogeneic DNTs as a therapy to treat patients with chemotherapy-resistant AML and also reveals interrelated roles of NKG2D, DNAM-1, and IFNgamma in selective targeting of AML by DNTs. 2,6-dinitrotoluene 317-321 interferon gamma Homo sapiens 0-8 29074605-6 2018 IFNgamma pretreatment enhances the susceptibility of AML cells to DNT-mediated cytotoxicity, including primary AML samples that are otherwise resistant to DNTs, and the effect of IFNgamma treatment is abrogated by NKG2D and DNAM-1-blocking antibodies.Conclusions: This study supports healthy donor-derived allogeneic DNTs as a therapy to treat patients with chemotherapy-resistant AML and also reveals interrelated roles of NKG2D, DNAM-1, and IFNgamma in selective targeting of AML by DNTs. 2,6-dinitrotoluene 317-321 interferon gamma Homo sapiens 179-187 29074605-6 2018 IFNgamma pretreatment enhances the susceptibility of AML cells to DNT-mediated cytotoxicity, including primary AML samples that are otherwise resistant to DNTs, and the effect of IFNgamma treatment is abrogated by NKG2D and DNAM-1-blocking antibodies.Conclusions: This study supports healthy donor-derived allogeneic DNTs as a therapy to treat patients with chemotherapy-resistant AML and also reveals interrelated roles of NKG2D, DNAM-1, and IFNgamma in selective targeting of AML by DNTs. 2,6-dinitrotoluene 317-321 interferon gamma Homo sapiens 179-187 29074605-6 2018 IFNgamma pretreatment enhances the susceptibility of AML cells to DNT-mediated cytotoxicity, including primary AML samples that are otherwise resistant to DNTs, and the effect of IFNgamma treatment is abrogated by NKG2D and DNAM-1-blocking antibodies.Conclusions: This study supports healthy donor-derived allogeneic DNTs as a therapy to treat patients with chemotherapy-resistant AML and also reveals interrelated roles of NKG2D, DNAM-1, and IFNgamma in selective targeting of AML by DNTs. 2,6-dinitrotoluene 66-69 interferon gamma Homo sapiens 0-8 29237778-8 2018 However, in contrast with CD4+ cells that were Ag primed in vivo, exogenous PGE2 inhibited proliferation and skewed IL-17A to IFN-gamma production under Th17 polarization of naive T cells in vitro. Dinoprostone 76-80 interferon gamma Homo sapiens 126-135 29237778-10 2018 Furthermore, we uncover a coordination of autocrine and paracrine mPGES1-driven PGE2 production that impacts effector T cell IL-17A and IFN-gamma responses. Dinoprostone 80-84 interferon gamma Homo sapiens 136-145 29259116-4 2018 However, CD8+ dT degranulated, proliferated, and produced IFN-gamma, TNF-alpha, perforin, and granzymes upon in vitro stimulation, demonstrating that CD8+ dT are not permanently suppressed and retain the capacity to respond to proinflammatory events, such as infections. Thymidine 14-16 interferon gamma Homo sapiens 58-67 29146246-7 2018 We demonstrate that the full efficacy of CP-Dox is dependent on CD8+ T cells and IFN-gamma. cp-dox 41-47 interferon gamma Homo sapiens 81-90 29576845-3 2018 When screening for immunomodulatory compounds, the two interferon gamma- (IFN-gamma-) dependent immunometabolic pathways of tryptophan breakdown via indoleamine 2,3-dioxygenase-1 (IDO-1) and neopterin formation by GTP-cyclohydrolase 1 (GTP-CH-I) represent prominent targets, as IFN-gamma-related signaling is strongly sensitive to oxidative triggers. Tryptophan 124-134 interferon gamma Homo sapiens 55-83 29576845-3 2018 When screening for immunomodulatory compounds, the two interferon gamma- (IFN-gamma-) dependent immunometabolic pathways of tryptophan breakdown via indoleamine 2,3-dioxygenase-1 (IDO-1) and neopterin formation by GTP-cyclohydrolase 1 (GTP-CH-I) represent prominent targets, as IFN-gamma-related signaling is strongly sensitive to oxidative triggers. Tryptophan 124-134 interferon gamma Homo sapiens 74-83 29576845-3 2018 When screening for immunomodulatory compounds, the two interferon gamma- (IFN-gamma-) dependent immunometabolic pathways of tryptophan breakdown via indoleamine 2,3-dioxygenase-1 (IDO-1) and neopterin formation by GTP-cyclohydrolase 1 (GTP-CH-I) represent prominent targets, as IFN-gamma-related signaling is strongly sensitive to oxidative triggers. Neopterin 191-200 interferon gamma Homo sapiens 55-83 29576845-3 2018 When screening for immunomodulatory compounds, the two interferon gamma- (IFN-gamma-) dependent immunometabolic pathways of tryptophan breakdown via indoleamine 2,3-dioxygenase-1 (IDO-1) and neopterin formation by GTP-cyclohydrolase 1 (GTP-CH-I) represent prominent targets, as IFN-gamma-related signaling is strongly sensitive to oxidative triggers. Neopterin 191-200 interferon gamma Homo sapiens 74-83 29343967-0 2018 Indoleamine 2,3-Dioxygenase Activity Increases NAD+ Production in IFN-gamma-Stimulated Human Primary Mononuclear Cells. NAD 47-51 interferon gamma Homo sapiens 66-75 29343967-1 2018 IFN-gamma activation of mononuclear phagocytes significantly increases indoleamine 2,3-dioxygenase (IDO) and flux through the kynurenine pathway (KP). Kynurenine 126-136 interferon gamma Homo sapiens 0-9 29343967-5 2018 IFN-gamma activation of macrophages resulted in the highest induction of IDO but decreased intracellular NAD+ concentrations at both 24 and 48 hours. NAD 105-109 interferon gamma Homo sapiens 0-9 29343967-6 2018 However, IFN-gamma activation of both day 6 and day 10 macrophages in the presence of a PARP inhibitor resulted in significantly higher intracellular NAD+ levels at 24 hours. NAD 150-154 interferon gamma Homo sapiens 9-18 28595944-5 2018 CMI cytokines, including IFN-gamma, TNFalpha and IL-1beta, induce the catabolism of tryptophan (TRY) by stimulating indoleamine 2,3-dioxygenase (IDO) resulting in the synthesis of kynurenine (KYN) and other tryptophan catabolites (TRYCATs). Kynurenine 180-190 interferon gamma Homo sapiens 25-34 28595944-5 2018 CMI cytokines, including IFN-gamma, TNFalpha and IL-1beta, induce the catabolism of tryptophan (TRY) by stimulating indoleamine 2,3-dioxygenase (IDO) resulting in the synthesis of kynurenine (KYN) and other tryptophan catabolites (TRYCATs). Tryptophan 84-94 interferon gamma Homo sapiens 25-34 28595944-5 2018 CMI cytokines, including IFN-gamma, TNFalpha and IL-1beta, induce the catabolism of tryptophan (TRY) by stimulating indoleamine 2,3-dioxygenase (IDO) resulting in the synthesis of kynurenine (KYN) and other tryptophan catabolites (TRYCATs). Kynurenine 192-195 interferon gamma Homo sapiens 25-34 28595944-5 2018 CMI cytokines, including IFN-gamma, TNFalpha and IL-1beta, induce the catabolism of tryptophan (TRY) by stimulating indoleamine 2,3-dioxygenase (IDO) resulting in the synthesis of kynurenine (KYN) and other tryptophan catabolites (TRYCATs). Tryptophan 207-217 interferon gamma Homo sapiens 25-34 28730964-8 2018 Pioglitazone inhibition of ANA proliferation was not associated with the effect on CCL2; NF-kappaB and ERK1/2 were basally activated in ANA, increased by IFN-gamma+TNF-alpha, and pioglitazone inhibited IFN- gamma+TNF-alpha activation. Pioglitazone 0-12 interferon gamma Homo sapiens 154-163 29160080-0 2018 Adjuvant Activity of Poly-epsilon-caprolactone/Chitosan Nanoparticles Characterized by Mast Cell Activation and IFN-gamma and IL-17 Production. polycaprolactone 21-46 interferon gamma Homo sapiens 112-121 29530430-8 2018 Additionally, the inflammatory markers, including NF-kappaB, T-bet, and IFN-gamma were higher in the TC group compared to TH group. Technetium 101-103 interferon gamma Homo sapiens 72-81 29530430-9 2018 The GSK-3beta activation index was positively correlated with the levels of NF-kappaB, T-bet, and IFN-gamma in the TC group. Technetium 115-117 interferon gamma Homo sapiens 98-107 33418684-5 2018 The results showed that the CDs as an intranasal vaccine delivery system enhanced the immunization efficacy by significantly increasing IgG titer, IgA induction in the local and distant mucous membrane sites, splenocyte proliferation, cytokine IFN-gamma secretion by splenocytes, and memory T cells. cds 28-31 interferon gamma Homo sapiens 244-253 30476917-7 2018 RESULTS: IFN-gamma and TNF permanently stopped cell proliferation and time-dependently increased SA-beta-gal activity. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid 97-108 interferon gamma Homo sapiens 9-18 30513523-10 2018 MiR-15 mimics induced nuclear translocation of NF-kappaB p65 and upregulated the expression of IL-8 and IFN-gamma in colonic epithelial cells; these effects were reversed by an miR-15 inhibitor. mir-15 0-6 interferon gamma Homo sapiens 104-113 30513523-10 2018 MiR-15 mimics induced nuclear translocation of NF-kappaB p65 and upregulated the expression of IL-8 and IFN-gamma in colonic epithelial cells; these effects were reversed by an miR-15 inhibitor. mir-15 177-183 interferon gamma Homo sapiens 104-113 29186698-9 2018 In addition, atorvastatin dose-dependently decreased basal and status epilepticus-induced levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (INF-gamma) and increased interleukin-10 (IL-10) levels in the hippocampus and cerebral cortex. Atorvastatin 13-25 interferon gamma Homo sapiens 197-213 29637862-6 2018 In this review article, the roles and consequences of the interferon gamma-dependent pathways of tryptophan breakdown and neopterin formation are discussed, as well as phenylalanine metabolism, trying to provide a rational link between immunology, metabolism and mental status. Tryptophan 97-107 interferon gamma Homo sapiens 58-74 29637862-6 2018 In this review article, the roles and consequences of the interferon gamma-dependent pathways of tryptophan breakdown and neopterin formation are discussed, as well as phenylalanine metabolism, trying to provide a rational link between immunology, metabolism and mental status. Neopterin 122-131 interferon gamma Homo sapiens 58-74 29186698-9 2018 In addition, atorvastatin dose-dependently decreased basal and status epilepticus-induced levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (INF-gamma) and increased interleukin-10 (IL-10) levels in the hippocampus and cerebral cortex. Atorvastatin 13-25 interferon gamma Homo sapiens 215-224 28513593-5 2018 We further demonstrate that the pan-JAK inhibitor tofacitinib and the specific JAK3 inhibitor PF-06651600 impair the ability of human intraepithelial ILC1 (iILC1) to produce IFN-gamma, without affecting ILC3 production of IL-22. tofacitinib 50-61 interferon gamma Homo sapiens 174-183 29605258-7 2018 Direct stimulation of macrophages in plaque sections with interferon-gamma caused a sustained increase in neopterin (p = .037) and total neopterin (p = .003). Neopterin 106-115 interferon gamma Homo sapiens 58-74 29605258-7 2018 Direct stimulation of macrophages in plaque sections with interferon-gamma caused a sustained increase in neopterin (p = .037) and total neopterin (p = .003). Neopterin 137-146 interferon gamma Homo sapiens 58-74 28581352-7 2018 RESULTS: Compared to the controls (MSCs alone), MSCs cocultured with IFN-gamma expressed significantly higher concentrations of PGE2, HGF and TGF-beta1. Dinoprostone 128-132 interferon gamma Homo sapiens 69-78 28581352-13 2018 The proinflammatory cytokine IFN-gamma exhibited synergistic effects with MSCs on immunosuppression, possibly by up-regulating PGE2, HGF and TGF-beta1 in MSCs and inducting MSCs expression of IDO, involved in tryptophan catabolism. Dinoprostone 127-131 interferon gamma Homo sapiens 29-38 28581352-13 2018 The proinflammatory cytokine IFN-gamma exhibited synergistic effects with MSCs on immunosuppression, possibly by up-regulating PGE2, HGF and TGF-beta1 in MSCs and inducting MSCs expression of IDO, involved in tryptophan catabolism. Tryptophan 209-219 interferon gamma Homo sapiens 29-38 29100036-0 2018 Nafamostat mesilate, a serine protease inhibitor, suppresses interferon-gamma-induced up-regulation of programmed cell death ligand 1 in human cancer cells. nafamostat 0-19 interferon gamma Homo sapiens 61-77 29100036-3 2018 Nafamostat mesilate (NM), a serine protease inhibitor that is frequently used in the clinic, potently suppressed interferon-gamma (IFN-gamma)-induced up-regulation of PD-L1 in cultured human lung cancer cells (HLC-1) at both the messenger RNA (mRNA) and protein levels. nafamostat 0-19 interferon gamma Homo sapiens 113-140 28219704-10 2018 Piperacillin-primed naive T cells from healthy volunteers also secreted IFN-gamma, IL-13, IL-22, and cytolytic molecules. Piperacillin 0-12 interferon gamma Homo sapiens 72-81 29167232-7 2018 Production of IFN-gamma and IL-27 was steroid-resistant, and neutralization of IFN-gamma or IL-27 significantly suppressed RSV-induced steroid-resistant airway hyperresponsiveness and airway inflammation. Steroids 38-45 interferon gamma Homo sapiens 14-23 29167232-7 2018 Production of IFN-gamma and IL-27 was steroid-resistant, and neutralization of IFN-gamma or IL-27 significantly suppressed RSV-induced steroid-resistant airway hyperresponsiveness and airway inflammation. Steroids 135-142 interferon gamma Homo sapiens 14-23 29167232-7 2018 Production of IFN-gamma and IL-27 was steroid-resistant, and neutralization of IFN-gamma or IL-27 significantly suppressed RSV-induced steroid-resistant airway hyperresponsiveness and airway inflammation. Steroids 135-142 interferon gamma Homo sapiens 79-88 28513593-5 2018 We further demonstrate that the pan-JAK inhibitor tofacitinib and the specific JAK3 inhibitor PF-06651600 impair the ability of human intraepithelial ILC1 (iILC1) to produce IFN-gamma, without affecting ILC3 production of IL-22. PF-06651600 94-105 interferon gamma Homo sapiens 174-183 29055264-7 2018 Venlafaxine treatment caused greater decreases in the levels of interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), interleukin 4 (IL-4), IL-5, IL-1beta, and IL-8 than did paroxetine. Venlafaxine Hydrochloride 0-11 interferon gamma Homo sapiens 64-91 29665345-0 2018 Evaluation of IFN-gamma Enzyme-linked Immunospot Assay (ELISPOT) as a First-line Test in the Diagnosis of Non-Immediate Hypersensitivity to Amoxicillin and Penicillin. Amoxicillin 140-151 interferon gamma Homo sapiens 14-23 29665345-3 2018 We aimed to verify the utility of IFN-gamma ELISPOT as a first-line test in patients with suspected non-immediate hypersensitivity reaction to amoxicillin (AMX) and penicillin (PNC). Amoxicillin 143-154 interferon gamma Homo sapiens 34-43 29665345-3 2018 We aimed to verify the utility of IFN-gamma ELISPOT as a first-line test in patients with suspected non-immediate hypersensitivity reaction to amoxicillin (AMX) and penicillin (PNC). Amoxicillin 156-159 interferon gamma Homo sapiens 34-43 29665345-3 2018 We aimed to verify the utility of IFN-gamma ELISPOT as a first-line test in patients with suspected non-immediate hypersensitivity reaction to amoxicillin (AMX) and penicillin (PNC). Penicillins 165-175 interferon gamma Homo sapiens 34-43 29665345-3 2018 We aimed to verify the utility of IFN-gamma ELISPOT as a first-line test in patients with suspected non-immediate hypersensitivity reaction to amoxicillin (AMX) and penicillin (PNC). Penicillins 177-180 interferon gamma Homo sapiens 34-43 29665345-8 2018 The highest IFN-gamma responses to AMX-CL were close to previously published criteria in three patients; one of which had true hypersensitivity according to drug provocation tests. amx-cl 35-41 interferon gamma Homo sapiens 12-21 29055264-8 2018 Paroxetine treatment increased the levels of proinflammatory cytokines IFN-gamma, TNF-alpha, and IL-6 and decreased Th2 cytokine levels. Paroxetine 0-10 interferon gamma Homo sapiens 71-80 29278364-8 2017 In terms of results, SK-N-MC cells treated with a combination of, but not individually with, IFN-gamma and TNF-alpha induced apoptosis characterized by hypodiploidy, DNA fragmentation, PARP cleavage, and increased caspase-8 activity. sk-n-mc 21-28 interferon gamma Homo sapiens 93-102 29269725-0 2017 Effect of Calcipotriol on IFN-gamma-Induced Keratin 17 Expression in Immortalized Human Epidermal Keratinocyte Cells. calcipotriene 10-22 interferon gamma Homo sapiens 26-35 29269725-2 2017 This study aims to investigate the effect of calcipotriol on IFN-gamma-induced keratin 17 (K17) expression in a human keratinocyte cell line (HaCaT), which is a widely accepted as a mimic in vitro model for psoriasis. calcipotriene 45-57 interferon gamma Homo sapiens 61-70 29269725-5 2017 The experimental results showed that calcipotriol at concentrations of 10^-7 M and 10^-5 M suppressed the IFN-gamma-induced K17 expression by 58.10% and 70.68%, respectively. calcipotriene 37-49 interferon gamma Homo sapiens 106-115 29269725-7 2017 CONCLUSIONS Our data suggest that calcipotriol downregulates IFN-gamma-mediated K17 expression in keratinocytes in a dose-dependent manner via VDRE effect GAS function. calcipotriene 34-46 interferon gamma Homo sapiens 61-70 29399410-7 2018 Cocultures of poly(I:C)-treated glioblastoma cells with peripheral blood mononuclear cells enhanced lymphocytic activation (CD69, IFN-gamma) and cytotoxic capacity (CD107a, granzyme B). Poly I-C 14-23 interferon gamma Homo sapiens 130-139 29207957-12 2017 At high percentiles of IL-1beta, IFN-gamma and IL-8, women with CDMR had higher expression levels compared to women with VD. cdmr 64-68 interferon gamma Homo sapiens 33-42 29225517-8 2017 Tofacitinib, dosed orally, intracecally, or applied to the colonic lumen in vitro, produced dose-dependent, and maximal inhibition of oxazolone or IFNgamma-induced STAT1 phosphorylation in the colon. tofacitinib 0-11 interferon gamma Homo sapiens 147-155 29207957-13 2017 Women with CDMI had higher levels at median percentiles of IL-1beta, IFN-gamma and IL-8. 2-(2-methyl-4-chlorophenylamino)-2-imidazoline 11-15 interferon gamma Homo sapiens 69-78 29255467-4 2017 A recent study found that IFN-gamma enhanced lipopolysaccharide-induced PGD2 production, indicating a role of IFNs in PGD2 regulation. Prostaglandin D2 72-76 interferon gamma Homo sapiens 26-35 28923396-5 2017 Similarly, pharmacological inhibitors of RIP1 (necrostatin-1(Nec-1)), RIP3 (GSK"872) or MLKL (necrosulfonamide (NSA)) significantly reduce BV6/IFNgamma-stimulated cell death. N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide 94-110 interferon gamma Homo sapiens 143-151 29182456-9 2017 Importantly, the levels of IFN-gamma and IL-10 consistently correlated with the generation of ROS, markers of damage and their free radical scavenging capacity. Reactive Oxygen Species 94-97 interferon gamma Homo sapiens 27-36 29207957-15 2017 It is worth noting that at high percentiles, compared with normal delivery, the expression of IL-1beta, IFN-gamma, IL-8 and HO-1 have significantly altered in women with CDMR. cdmr 170-174 interferon gamma Homo sapiens 104-113 29157836-8 2017 We show that plasmatic neopterin levels, a molecule released by IFN-gamma-activated macrophages, is predictive of mortality in HFP (ROC-AUC=0.859). Neopterin 23-32 interferon gamma Homo sapiens 64-73 29255467-4 2017 A recent study found that IFN-gamma enhanced lipopolysaccharide-induced PGD2 production, indicating a role of IFNs in PGD2 regulation. Prostaglandin D2 118-122 interferon gamma Homo sapiens 26-35 29255467-5 2017 Here, we demonstrate that TLR-induced PGD2 production by macrophages was significantly potentiated by signaling common to IFN-beta and IFN-gamma in a signal transducer and activators of transcription (STAT)1-dependent mechanism. Prostaglandin D2 38-42 interferon gamma Homo sapiens 135-144 29155869-5 2017 We found that PPS enhanced the activities of IFN-gamma-stimulated RAW 264.7 macrophages, as shown by the release of inducible nitric oxide synthase (INOS), secretion of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, phagocytosis activity, as well as expression of M1 phenotype indicators, such as CD40, CD284 and CD86. pps 14-17 interferon gamma Homo sapiens 45-54 29140946-1 2017 BACKGROUND: Diagnosis of latent tuberculosis infection (LTBI) is facilitated by tuberculin skin testing (TST) or interferon-gamma release assays such as the QuantiFERON TB Gold In-Tube (QTF-GIT) assays. tb gold 169-176 interferon gamma Homo sapiens 113-129 28748356-13 2017 RESULTS: We demonstrated that TAMs could induce the expression of PD-L1 by the secretion of IFN-gamma through the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway and the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway in A549 cells. Tamoxifen 30-34 interferon gamma Homo sapiens 92-101 28748356-14 2017 Furthermore, the signal pathway blockers LY294002 or AG490 could block the induced expression of PD-L1 by IFN-gamma. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 41-49 interferon gamma Homo sapiens 106-115 28748356-14 2017 Furthermore, the signal pathway blockers LY294002 or AG490 could block the induced expression of PD-L1 by IFN-gamma. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 53-58 interferon gamma Homo sapiens 106-115 29185908-2 2017 In the present study, the growth inhibition kinetics of recombinant P. pastoris expressing human interferon gamma was studied under different initial substrate concentrations of gluconate (10-100 g L-1) and methanol (2-50 g L-1) in modified FM22 medium. gluconic acid 178-187 interferon gamma Homo sapiens 97-113 29185908-2 2017 In the present study, the growth inhibition kinetics of recombinant P. pastoris expressing human interferon gamma was studied under different initial substrate concentrations of gluconate (10-100 g L-1) and methanol (2-50 g L-1) in modified FM22 medium. Methanol 207-215 interferon gamma Homo sapiens 97-113 28991491-4 2017 In this study, we explored the use of silicon nanowires (NWs) as a way to create nanostructured electrodes with enhanced sensitivity for IFN-gamma. Silicon 38-45 interferon gamma Homo sapiens 137-146 28991491-5 2017 Si NWs were covered with gold and were further functionalized with thiolated aptamers specific for IFN-gamma. Silicon 0-2 interferon gamma Homo sapiens 99-108 28786129-8 2017 We estimate the controlled direct effect of air pollution on the qth percentile of fibrinogen and its indirect effect through a change in the pth percentile of IFN-gamma methylation. pth 142-145 interferon gamma Homo sapiens 160-169 29125561-0 2017 Dimethyl Sulfoxide (DMSO) Decreases Cell Proliferation and TNF-alpha, IFN-gamma, and IL-2 Cytokines Production in Cultures of Peripheral Blood Lymphocytes. Dimethyl Sulfoxide 0-18 interferon gamma Homo sapiens 70-79 28982342-4 2017 RESULTS: Polyphenols were able to reduce the increased release of interferon-gamma and interleukin (IL)-4, while maintaining the equilibrium between IL-10 and IL-17. Polyphenols 9-20 interferon gamma Homo sapiens 66-82 29125561-0 2017 Dimethyl Sulfoxide (DMSO) Decreases Cell Proliferation and TNF-alpha, IFN-gamma, and IL-2 Cytokines Production in Cultures of Peripheral Blood Lymphocytes. Dimethyl Sulfoxide 20-24 interferon gamma Homo sapiens 70-79 29125561-7 2017 DMSO at 1% and 2% v/v concentrations reduced the relative proliferation index of lymphocytes and at 5% and 10% v/v concentrations reduced the percentage of total lymphocytes, cluster of differentiation 4+ (CD4+) T lymphocytes and CD8+ T lymphocytes interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2) producers. Dimethyl Sulfoxide 0-4 interferon gamma Homo sapiens 249-265 29125561-7 2017 DMSO at 1% and 2% v/v concentrations reduced the relative proliferation index of lymphocytes and at 5% and 10% v/v concentrations reduced the percentage of total lymphocytes, cluster of differentiation 4+ (CD4+) T lymphocytes and CD8+ T lymphocytes interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2) producers. Dimethyl Sulfoxide 0-4 interferon gamma Homo sapiens 267-276 29127315-9 2017 We found that infusion of GMSCs but not fibroblast cells significantly controlled blood glucose levels, delayed diabetes onset, ameliorated pathology scores in pancreas, and down-regulated production of IL-17 and IFN-gamma in CD4+ and CD8+ T cells in spleens, pancreatic lymph nodes (pLN) and other lymph nodes. gmscs 26-31 interferon gamma Homo sapiens 213-222 28855352-8 2017 Cyclophosphamide-treated patients demonstrating the most enhanced IFNgamma+ tumor-specific T-cell responses exhibited a significant delay in tumor progression [HR = 0.29; 95% confidence interval (CI), 0.12-0.69; P = 0.0047), compared with nonresponders and no-treatment controls.Conclusions: Cyclophosphamide-induced Treg depletion is mirrored by a striking boost in antitumor immunity. Cyclophosphamide 0-16 interferon gamma Homo sapiens 66-74 28855352-8 2017 Cyclophosphamide-treated patients demonstrating the most enhanced IFNgamma+ tumor-specific T-cell responses exhibited a significant delay in tumor progression [HR = 0.29; 95% confidence interval (CI), 0.12-0.69; P = 0.0047), compared with nonresponders and no-treatment controls.Conclusions: Cyclophosphamide-induced Treg depletion is mirrored by a striking boost in antitumor immunity. Cyclophosphamide 292-308 interferon gamma Homo sapiens 66-74 28444847-7 2017 Remarkably, peritransplantation administration of C1-INH prolonged graft survival (MST >60 days, p < 0.05 vs. controls, n = 6) and prevented CI-induced increases in donor-reactive, IFNgamma-producing spleen cells (p < 0.05). morin 147-149 interferon gamma Homo sapiens 187-195 27647321-5 2017 Aluminum hydroxide-NPs were demonstrated excellent effects to raise of IFN-gamma secretion in compare to EsxV alone. Aluminum Hydroxide 0-18 interferon gamma Homo sapiens 71-80 28683358-7 2017 AFBN patients showed higher serum levels of IFN-gamma, IL-6, IL-10 and soluble TNF-receptor 1 (sTNFR1) (all p<0.05). afbn 0-4 interferon gamma Homo sapiens 44-53 28683358-11 2017 IFN-gamma and IL-6 levels might most effectively distinguish AFBN from APN. afbn 61-65 interferon gamma Homo sapiens 0-9 29332347-9 2017 RESULTS: The combination of two cytokines (IFN-gamma and IL- 10) engineered into BMSCs resulted in a significant reduction in HepG2 cell viability (*p<0.05 vs PBS-treated and #p<0.05 vs BMSC-treated group). Lead 162-165 interferon gamma Homo sapiens 43-52 29798120-7 2017 Compared with the control group, the observation group was significantly better than the control group (P < 0.01).Conclusion:The combination of Saccharomyces boulardi and levocetirine hydrochloride in the treatment of children with AR has obvious clinical efficacy, and its mechanism may be related to the correction of interferon IFN-gamma and IL-4. levocetirine hydrochloride 174-200 interferon gamma Homo sapiens 334-343 29332347-9 2017 RESULTS: The combination of two cytokines (IFN-gamma and IL- 10) engineered into BMSCs resulted in a significant reduction in HepG2 cell viability (*p<0.05 vs PBS-treated and #p<0.05 vs BMSC-treated group). BMSC 81-85 interferon gamma Homo sapiens 43-52 28715559-5 2017 Objective: To determine whether the TH1 cytokine interferon-gamma inhibits the function of LTS-derived fibroblasts in vitro. lts 91-94 interferon gamma Homo sapiens 49-65 28901435-7 2017 The nuclear factor-kappaB inhibitor, Bay 11-7082, decreased the TNF-alpha-mediated expression of IL-8 and CXCL10 in the absence, and presence of IFN-gamma. 3-(4-methylphenylsulfonyl)-2-propenenitrile 37-48 interferon gamma Homo sapiens 145-154 29227276-5 2017 In the present study we examined the expression of IFN-gamma and IL-10 by CF T cells prior to and following 5-azaC treatment. Azacitidine 108-114 interferon gamma Homo sapiens 51-60 29227276-11 2017 After 5-azaC treatment secretion of IFN-gamma was significantly decreased in CF T cells, while amount of IL-10 was elevated by ~2.5 times compared to untreated controls (P<0.05). Azacitidine 6-12 interferon gamma Homo sapiens 36-45 28920951-4 2017 Preventing the activation of Srebp or direct inhibition of the citrate-malate shuttle inhibited production of interferon-gamma and NK cell cytotoxicity. citrate-malate 63-77 interferon gamma Homo sapiens 110-126 29268845-5 2017 Results Tofacitinib inhibited the production of IFN-gamma, TNF-alpha and the expression of CD25 on T cells from the peripheral blood. tofacitinib 8-19 interferon gamma Homo sapiens 48-57 29268845-8 2017 Conclusion Tofacitinib can inhibit the secretion of IFN-gamma and TNF-alpha by T cells in the peripheral blood, and its mechanism might be related to the inhibitory effect of tofacitinib on the activation, proliferation and signal transduction in T cells. tofacitinib 11-22 interferon gamma Homo sapiens 52-61 29268845-8 2017 Conclusion Tofacitinib can inhibit the secretion of IFN-gamma and TNF-alpha by T cells in the peripheral blood, and its mechanism might be related to the inhibitory effect of tofacitinib on the activation, proliferation and signal transduction in T cells. tofacitinib 175-186 interferon gamma Homo sapiens 52-61 28622139-7 2017 Particularly, key immunoregulatory cytokines such as IL-4 and IFN-gamma shape the cellular eicosanoid profile, thus providing efficient feedback regulation between cytokine and eicosanoid networks. Eicosanoids 91-101 interferon gamma Homo sapiens 62-71 28622139-7 2017 Particularly, key immunoregulatory cytokines such as IL-4 and IFN-gamma shape the cellular eicosanoid profile, thus providing efficient feedback regulation between cytokine and eicosanoid networks. Eicosanoids 177-187 interferon gamma Homo sapiens 62-71 28901435-8 2017 In addition, the JAK2 inhibitor, AG490, decreased CXCL10 expression when administered with TNF-alpha and IFN-gamma. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 33-38 interferon gamma Homo sapiens 105-114 29085809-6 2017 immunization with MCS-DNA induced a modest peptide-specific Th1(IFN-gamma, TNF-alpha, and IL-2) response in the spleen, while a potent poly-functional CD4+ T response that largely produced TNF-alpha and IFN-gamma, as well as IL-2 in the lung, qualitatively better than that induced by CS-DNA and BCG vaccination. mcs 18-21 interferon gamma Homo sapiens 64-73 28604752-9 2017 Furthermore, we found that lactate-induced activation of PD-L1 in tumor cells led to reduced production of interferon-gamma and induction of apoptosis of cocultured Jurkat T-cell leukemia cells. Lactic Acid 27-34 interferon gamma Homo sapiens 107-123 29152046-5 2017 Cytokine profiles are also reported that show the pure TLR8 agonist [4-amino-2-butyl-1-(2-aminoethyl)-7-methoxycarbonyl-1H-imidazo[4,5-c]quinoline] induces higher levels of IL-1beta, IL-12, and IFNgamma when compared with TLR7 selective or mixed TLR7/8 agonists. 4-amino-2-butyl-1-(2-aminoethyl)-7-methoxycarbonyl-1h-imidazo[4,5-c]quinoline 69-146 interferon gamma Homo sapiens 194-202 29085809-6 2017 immunization with MCS-DNA induced a modest peptide-specific Th1(IFN-gamma, TNF-alpha, and IL-2) response in the spleen, while a potent poly-functional CD4+ T response that largely produced TNF-alpha and IFN-gamma, as well as IL-2 in the lung, qualitatively better than that induced by CS-DNA and BCG vaccination. mcs 18-21 interferon gamma Homo sapiens 203-212 28830889-10 2017 Long-term OS was correlated with interferon-gamma+ and tumor necrosis factor-alpha+ WT1-specific responses in delayed-type hypersensitivity-infiltrating CD8+ T lymphocytes. Osmium 10-12 interferon gamma Homo sapiens 33-82 28706011-5 2017 In clinical trials, increased IFNgamma+ T cells and increased T-cell cytotoxicity predicted improved therapeutic responses and survival in the test cohort and validation cohort.Conclusions: We find that low-dose decitabine therapy promotes antitumor T-cell responses by promoting T-cell proliferation and the increased IFNgamma+ T cells may act as a potential prognostic biomarker for the response to decitabine-based antitumor therapy. Decitabine 212-222 interferon gamma Homo sapiens 319-327 28706011-0 2017 Increased IFNgamma+ T Cells Are Responsible for the Clinical Responses of Low-Dose DNA-Demethylating Agent Decitabine Antitumor Therapy. Decitabine 107-117 interferon gamma Homo sapiens 10-18 28706011-4 2017 Kaplan-Meier and Cox proportional hazard regression analysis were performed to investigate the prognostic value of enhanced T-cell activity following decitabine epigenetic therapy.Results: Low-dose decitabine therapy enhanced the activation and proliferation of human IFNgamma+ T cells, promoted Th1 polarization and activity of cytotoxic T cells both in vivo and in vitro, which in turn inhibited cancer progression and augmented the clinical effects of patients. Decitabine 198-208 interferon gamma Homo sapiens 268-276 28706011-5 2017 In clinical trials, increased IFNgamma+ T cells and increased T-cell cytotoxicity predicted improved therapeutic responses and survival in the test cohort and validation cohort.Conclusions: We find that low-dose decitabine therapy promotes antitumor T-cell responses by promoting T-cell proliferation and the increased IFNgamma+ T cells may act as a potential prognostic biomarker for the response to decitabine-based antitumor therapy. Decitabine 212-222 interferon gamma Homo sapiens 30-38 28736282-8 2017 Curcumin inhibited the proliferation of IMQ-induced differentiated HaCaT cells (Psoriatic-like cells) by down-regulation of pro-inflammatory cytokines, interleukin-17, tumor necrosis factor-alpha, interferon-gamma, and interleukin-6. Curcumin 0-8 interferon gamma Homo sapiens 197-213 28736282-8 2017 Curcumin inhibited the proliferation of IMQ-induced differentiated HaCaT cells (Psoriatic-like cells) by down-regulation of pro-inflammatory cytokines, interleukin-17, tumor necrosis factor-alpha, interferon-gamma, and interleukin-6. Imiquimod 40-43 interferon gamma Homo sapiens 197-213 28856908-5 2017 Butyrate significantly down-regulated the expression of genes involved in inflammatory response, among which nuclear factor kappa beta, interferon-gamma, Toll like 2 receptor and tumour necrosis factor-alpha. Butyrates 0-8 interferon gamma Homo sapiens 136-152 28736999-7 2017 The inflammatory cytokine IFN-gamma positive Treg cells were found to be elevated in CD as compared to control group. Cadmium 85-87 interferon gamma Homo sapiens 26-35 29207601-9 2017 TGFbeta receptor kinase inhibitor SB431542 interfered with the suppressive activity of ATG-primed cells, enabling partial rescue of proliferation and IFNgamma secretion. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 34-42 interferon gamma Homo sapiens 150-158 28601925-5 2017 Overall, addition of IFNgamma and the TLR7/8 agonist R848 during maturation was essential for the production of high levels of IL-12p70 which was further augmented by adding the TLR3 agonist poly I:C. Poly I-C 191-199 interferon gamma Homo sapiens 21-29 28665482-8 2017 In contrast, BBG injection reduced circulating human interferon (IFN)-gamma significantly, which was produced by human CD4+ and CD8+ T cells. coomassie Brilliant Blue 13-16 interferon gamma Homo sapiens 53-75 28736999-12 2017 A strong correlation was observed between the cytokine IFN-gamma and TLR2 expression in movement of iTregs in CD patients. Cadmium 110-112 interferon gamma Homo sapiens 55-64 29131243-0 2017 Photodynamic therapy with 5-aminolevulinic acid suppresses IFN-gamma-induced K17 expression in HaCaT cells via MAPK pathway. 5-amino levulinic acid 26-47 interferon gamma Homo sapiens 59-68 28803068-4 2017 Hydrophilic Interaction Liquid Chromatography determined the structure of N-linked glycans present in HEK293-expressed hIFNgamma (hIFNgamma-HEK). n-linked glycans 74-90 interferon gamma Homo sapiens 119-128 28803068-4 2017 Hydrophilic Interaction Liquid Chromatography determined the structure of N-linked glycans present in HEK293-expressed hIFNgamma (hIFNgamma-HEK). n-linked glycans 74-90 interferon gamma Homo sapiens 130-139 28803068-6 2017 Complex-type oligosaccharides dominated the N-glycosylation pattern of hIFNgamma-HEK with some terminal sialylation and core fucosylation. complex-type oligosaccharides 0-29 interferon gamma Homo sapiens 71-80 28803068-6 2017 Complex-type oligosaccharides dominated the N-glycosylation pattern of hIFNgamma-HEK with some terminal sialylation and core fucosylation. Nitrogen 44-45 interferon gamma Homo sapiens 71-80 28827003-6 2017 All tested extracts and molecules also induced release of IFN-gamma remarkably ranging between 5031.95+-0.05pg/mL, P<0.001 for MeOH extract (6mug) and 5877.08+-0.06pg/mL, P<0.001 for compound 1 (6mug) compared to QS-21 (6mug, 5924.87+-0.1pg/mL, P<0.001). Methanol 130-134 interferon gamma Homo sapiens 58-67 28707358-7 2017 Animals with EAE receiving DHEA-S treatment showed reduced Il1b and Ifng transcript levels in spinal cord compared to vehicle-treated animals with EAE. Dehydroepiandrosterone 27-33 interferon gamma Homo sapiens 68-72 29228683-4 2017 We found that lenalidomide enhances the antigen-specific secretion of IFN-gamma and Granzyme B despite the addition of CD8+CD28- T-cells. Lenalidomide 14-26 interferon gamma Homo sapiens 70-79 29228683-6 2017 The addition of IL-6 counteracts the action of lenalidomide based stimulation of IFN-gamma secretion and induction of T-cell maturation but not the secretion of Granzyme B. Lenalidomide 47-59 interferon gamma Homo sapiens 81-90 28802902-7 2017 Particularly in CIK cells, PA-MSHA promoted the extrusion of pro-inflammatory cytokines like IFN-gamma. pa-msha 27-34 interferon gamma Homo sapiens 93-102 28167299-9 2017 Calcipotriol and dexamethasone additively reduced the secretions of IL-6, IFN-gamma, basic FGF and VEGF in TNF-alpha stimulated SSC. calcipotriene 0-12 interferon gamma Homo sapiens 74-83 28167299-9 2017 Calcipotriol and dexamethasone additively reduced the secretions of IL-6, IFN-gamma, basic FGF and VEGF in TNF-alpha stimulated SSC. Dexamethasone 17-30 interferon gamma Homo sapiens 74-83 28962697-8 2017 RESULTS: PTX preferentially inhibited placental expression and production of LPS-induced pro-inflammatory cytokines including TNF-alpha (25461 vs. 1908 pg/ml, p < 0.001), IL-1beta (2921 vs. 1067 pg/ml, p < 0.001) and IFN-gamma (2190 vs 427 pg/ml, p < 0.001) with relative preservation of anti-inflammatory mediators. Pentoxifylline 9-12 interferon gamma Homo sapiens 223-232 28649995-9 2017 25-OH vitamin D was inversely associated with IFN-gamma levels. 25-oh vitamin d 0-15 interferon gamma Homo sapiens 46-55 29031722-7 2017 In contrast, LPS/IFNgamma-activated MPhis showed high CD40 and low CD163 expression and secreted factors that enhanced adipocyte mitochondrial activity resulting in a total difference of 37% in ATP-linked respiration of white adipocytes (p = 0.0024) when comparing the effect of LPS/IFNgamma- vs IL10/TGFbeta-activated MPhis. Adenosine Triphosphate 194-197 interferon gamma Homo sapiens 17-25 28664925-10 2017 Following stimulation, lymphocytes of ELS+ adolescents produced significantly more IL-2, IL-4, IFN-gamma, and IL-17 and engaged more MAPK ERK and NF-kappaB signaling. N-[(2S,3S,4R)-3,4-dihydroxy-8-oxo-8-[(4-pentylphenyl)amino]-1-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octan-2-yl]hexacosanamide 38-41 interferon gamma Homo sapiens 95-104 28874142-9 2017 In multivariate analysis, the variables independently associated with increased IFN-gamma production in response to PPD antigen were CD4+ T cell counts <200 cells/mm3 at baseline, age, site of tuberculosis, 800 mg efavirenz dose and follow-up CD4+ T cell counts. efavirenz 217-226 interferon gamma Homo sapiens 80-89 28954232-5 2017 IFNgamma upregulated microsomal prostaglandin E synthase-1 (mPGES-1) alongside cyclo-oxygenase (COX-1) within macrophage populations, resulting in sustained prostaglandin (PG)E2 biosynthesis. Dinoprostone 157-177 interferon gamma Homo sapiens 0-8 28367883-11 2017 Serial QFT-IT for evaluating IPT effectiveness had limitations because of delayed or lack of reversion, especially for patients with high baseline IFN-gamma levels. isoprothiolane 29-32 interferon gamma Homo sapiens 147-156 28914761-10 2017 Additionally, these two flavonolignans abolished the IL-1beta-induced expression of mRNA for IFN-gamma and TNF. Flavonolignans 24-38 interferon gamma Homo sapiens 93-102 29263880-6 2017 Depletion strategies showed that this early IFNgamma production was essential for the activation of dendritic cells and the development of Th1 immunity by AS01-adjuvanted vaccine. as01 155-159 interferon gamma Homo sapiens 44-52 28883439-6 2017 T cell MHP was associated with increased activation-induced IFNgamma production, and activation-induced IFNgamma was linked to mitochondria-specific ROS production. ros 149-152 interferon gamma Homo sapiens 104-112 28883439-8 2017 In conclusion, intrinsic mitochondrial dysfunction observed in type 1 diabetes alters mitochondrial ATP and IFNgamma production; the latter is correlated with ROS generation. ros 159-162 interferon gamma Homo sapiens 108-116 28739303-6 2017 RESULTS: CpG oligonucleotides specifically enhanced HBsAg-mediated IL2 (276+-79pg/ml vs. 320+-82pg/ml) and IFNgamma (77+-35pg/ml vs. 401+-121pg/ml) responses in whole blood. Oligonucleotides 13-29 interferon gamma Homo sapiens 107-115 28953967-0 2017 Malaria-induced interferon-gamma drives the expansion of Tbethi atypical memory B cells. tbethi 57-63 interferon gamma Homo sapiens 16-32 28876002-6 2017 Significantly, our results also demonstrate the increase of surface guanidyl on nanoparticles modulates the depot effect and lymph node drainage of PECG NPs-based adjuvants, as well as immune responses, by regulating the secretion of cytokines including IFN-gamma and TNF-alpha. guanidyl 68-76 interferon gamma Homo sapiens 254-263 29263880-0 2017 Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNgamma response promoting vaccine immunogenicity. as01 34-38 interferon gamma Homo sapiens 79-87 29263880-4 2017 Hours after injection of AS01-adjuvanted vaccine, resident cells, such as NK cells and CD8+ T cells, release IFNgamma in the lymph node draining the injection site. as01 25-29 interferon gamma Homo sapiens 109-117 28688912-3 2017 The aim of this study was to examine the effect of IFNgamma-stimulated kynurenine pathway (KP) induction in microglia on neurite outgrowth and complexity, and to determine whether alterations could be abrogated using pharmacological inhibitors of the KP. Kynurenine 71-81 interferon gamma Homo sapiens 51-59 28688912-6 2017 Results show increased mRNA expression of IDO, KMO and KYNU, and increased concentrations of tryptophan, kynurenine, and 3-hydroxykynurenine in the CM of IFNgamma-stimulated BV-2 microglia. Tryptophan 93-103 interferon gamma Homo sapiens 154-162 28688912-6 2017 Results show increased mRNA expression of IDO, KMO and KYNU, and increased concentrations of tryptophan, kynurenine, and 3-hydroxykynurenine in the CM of IFNgamma-stimulated BV-2 microglia. Kynurenine 105-115 interferon gamma Homo sapiens 154-162 28688912-6 2017 Results show increased mRNA expression of IDO, KMO and KYNU, and increased concentrations of tryptophan, kynurenine, and 3-hydroxykynurenine in the CM of IFNgamma-stimulated BV-2 microglia. 3-hydroxykynurenine 121-140 interferon gamma Homo sapiens 154-162 28894451-9 2017 Indoleamine 2,3 dioxygenase expression was highly induced in MSC-IFN-gamma and was responsible of the anti-proliferative and Breg reduction since addition of tryptophan (TRP) restored MSC properties. Tryptophan 158-168 interferon gamma Homo sapiens 65-74 28398068-4 2017 Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-gamma, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-beta, IL-1, and IL-17, compared to their placebo counterparts. l-gsh 46-51 interferon gamma Homo sapiens 130-139 28425113-9 2017 Collectively, these findings indicate that PFOS is capable of inducing proinflammatory interferon-gamma, but not immunoregulatory interleukin-4 production in T cells, which may establish a state of chronic immune activation known to be associated with susceptibility to disease. perfluorooctane sulfonic acid 43-47 interferon gamma Homo sapiens 87-103 28843559-0 2017 An amplified fluorescent aptasensor based on single-stranded DNA binding protein, copper and silica nanoparticles for sensitive detection of interferon-gamma. Copper 82-88 interferon gamma Homo sapiens 141-157 28843559-0 2017 An amplified fluorescent aptasensor based on single-stranded DNA binding protein, copper and silica nanoparticles for sensitive detection of interferon-gamma. Silicon Dioxide 93-99 interferon gamma Homo sapiens 141-157 28843559-4 2017 The presences of double-stranded DNA (dsDNA) region and poly thymine (T) in the hairpin structure of the oligonucleotide, SSB and SNPs-streptavidin caused IFN-gamma determination with high selectivity and sensitivity. poly thymine 56-68 interferon gamma Homo sapiens 155-164 28843559-4 2017 The presences of double-stranded DNA (dsDNA) region and poly thymine (T) in the hairpin structure of the oligonucleotide, SSB and SNPs-streptavidin caused IFN-gamma determination with high selectivity and sensitivity. Oligonucleotides 105-120 interferon gamma Homo sapiens 155-164 28843559-5 2017 Upon addition of IFN-gamma, the hairpin structure of the oligonucleotide was disassembled and therefore, poly T strand interacted with SSB and a weak fluorescence signal was obtained. Oligonucleotides 57-72 interferon gamma Homo sapiens 17-26 28863172-12 2017 Lastly, the pro-inflammatory cytokine combination of TNF-alpha and IFN-gamma elevated extracellular uric acid levels and XDH gene expression in HBEC-6KT cells. Uric Acid 100-109 interferon gamma Homo sapiens 67-76 28894451-9 2017 Indoleamine 2,3 dioxygenase expression was highly induced in MSC-IFN-gamma and was responsible of the anti-proliferative and Breg reduction since addition of tryptophan (TRP) restored MSC properties. Tryptophan 170-173 interferon gamma Homo sapiens 65-74 28894045-3 2017 It is produced by human monocytes/macrophages and dendritic cells from guanosine triphosphate (GTP) upon stimulation with interferon gamma (IFNgamma), which is released by activated limphocytes Th. Guanosine Triphosphate 71-93 interferon gamma Homo sapiens 122-149 28837583-6 2017 Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-gamma) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (< 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-gamma secretion. Tetradecanoylphorbol Acetate 195-226 interferon gamma Homo sapiens 147-174 28837583-6 2017 Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-gamma) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (< 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-gamma secretion. Tetradecanoylphorbol Acetate 195-226 interferon gamma Homo sapiens 165-174 28837583-6 2017 Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-gamma) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (< 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-gamma secretion. Tetradecanoylphorbol Acetate 228-231 interferon gamma Homo sapiens 147-174 28837583-6 2017 Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-gamma) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (< 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-gamma secretion. Tetradecanoylphorbol Acetate 228-231 interferon gamma Homo sapiens 165-174 28837583-6 2017 Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-gamma) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (< 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-gamma secretion. Ionomycin 237-246 interferon gamma Homo sapiens 147-174 28837583-6 2017 Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-gamma) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (< 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-gamma secretion. Ionomycin 237-246 interferon gamma Homo sapiens 165-174 28855623-5 2017 At equivalent concentrations, a single oral dose of PLGA-curcumin was more effective in inhibiting serum IFNgamma levels and enhancing IL-10 levels than native curcumin. Curcumin 57-65 interferon gamma Homo sapiens 105-113 29137411-5 2017 The PBT anti-tumor effect was accompanied by an increase in granzyme B+, IFN-gamma+ CD8+ T-cells and a decrease in immunosuppressive tumor infiltrating cells including Gr-1+CD11b+ myeloid derived suppressor cells (MDSCs), CD4+CD25+ Tregs, and CD206+F4/80+ M2 macrophages. (E)-2-(pent-3-en-1-yn-1-yl)thiophene 4-7 interferon gamma Homo sapiens 73-82 28894045-3 2017 It is produced by human monocytes/macrophages and dendritic cells from guanosine triphosphate (GTP) upon stimulation with interferon gamma (IFNgamma), which is released by activated limphocytes Th. Guanosine Triphosphate 95-98 interferon gamma Homo sapiens 122-149 28806909-6 2017 Furthermore, the T cell SP was characterized for the attenuation of IFN-gamma production. sp 24-26 interferon gamma Homo sapiens 68-77 28801380-5 2017 Similarly, vitamin D can induce or inhibit the synthesis, secretion, and release of anti- inflammatory (IL-4 and IL-10) and pro-inflammatory (IL-1, TNF-alpha, IFN-gamma) cytokines, respectively. Vitamin D 11-20 interferon gamma Homo sapiens 159-168 28368400-0 2017 Interferon gamma is a STAT1-dependent direct inducer of BCL6 expression in imatinib-treated chronic myeloid leukemia cells. Imatinib Mesylate 75-83 interferon gamma Homo sapiens 0-16 28444425-9 2017 We observed that pro-inflammatory cytokines such as IFN-gamma, IL-2, IL-12, and IL-23 were markedly reduced with the use of methotrexate, in comparison to the baseline levels, while the plasma IL-4 levels were increased posttreatment. Methotrexate 124-136 interferon gamma Homo sapiens 52-61 28764751-6 2017 Short term exposure (3 h) to a combination of amphotericin B (1 microg/ml) and IFN-gamma (32 pg/ml) increased the effectiveness of amphotericin B against A. fumigatus and S. cerevisiae but not Candida albicans. Amphotericin B 131-145 interferon gamma Homo sapiens 79-88 28764751-7 2017 These data suggest that IFN-gamma does not possess strong antifungal activity but can enhance the effect of amphotericin B under some testing conditions against Aspergillus species. Amphotericin B 108-122 interferon gamma Homo sapiens 24-33 27376248-8 2017 Our results demonstrated that DMF and MMF dose-dependently reduced the levels of L-kynurenine in PBMCs activated by interferon-gamma (IFN-gamma). Dimethyl Fumarate 30-33 interferon gamma Homo sapiens 116-132 27376248-8 2017 Our results demonstrated that DMF and MMF dose-dependently reduced the levels of L-kynurenine in PBMCs activated by interferon-gamma (IFN-gamma). Dimethyl Fumarate 30-33 interferon gamma Homo sapiens 134-143 27376248-8 2017 Our results demonstrated that DMF and MMF dose-dependently reduced the levels of L-kynurenine in PBMCs activated by interferon-gamma (IFN-gamma). mmf 38-41 interferon gamma Homo sapiens 116-132 27376248-8 2017 Our results demonstrated that DMF and MMF dose-dependently reduced the levels of L-kynurenine in PBMCs activated by interferon-gamma (IFN-gamma). mmf 38-41 interferon gamma Homo sapiens 134-143 27376248-8 2017 Our results demonstrated that DMF and MMF dose-dependently reduced the levels of L-kynurenine in PBMCs activated by interferon-gamma (IFN-gamma). Kynurenine 81-93 interferon gamma Homo sapiens 116-132 27376248-8 2017 Our results demonstrated that DMF and MMF dose-dependently reduced the levels of L-kynurenine in PBMCs activated by interferon-gamma (IFN-gamma). Kynurenine 81-93 interferon gamma Homo sapiens 134-143 28656203-0 2017 1-Methyl-L-tryptophan promotes the apoptosis of hepatic stellate cells arrested by interferon-gamma by increasing the expression of IFN-gammaRbeta, IRF-1 and FAS. 1-Methyl-L-tryptophan 0-21 interferon gamma Homo sapiens 83-99 28759590-5 2017 In contrast, the cytokine profile of Mtb-specific CD4 T cells of TB patients from SA was dominated by single IFN-gamma and dual IFN-gamma/TNF-alpha and associated with TB-induced systemic inflammation and elevated serum levels of type I IFNs. Terbium 65-67 interferon gamma Homo sapiens 109-118 28656203-4 2017 The IDO inhibitor, 1-methyl-L-tryptophan (1-MT), was used to determine whether IDO plays a key role in the regulation of activated HSCs, as IFN-gamma increases the expression of IDO. 1-Methyl-L-tryptophan 19-40 interferon gamma Homo sapiens 140-149 28628108-6 2017 The mTORC1 and IFN-gamma production defects were partially rescued by supplementation with glutamine, which requires CARD11 for import into T cells. Glutamine 91-100 interferon gamma Homo sapiens 15-24 28536054-6 2017 We observed a decreased interferon-gamma (IFNgamma) secretion by CD4+ T cells in vitamin D deficient group but not in the sufficient group, and a negative correlation between baseline serum vitamin D and IFNgamma production. Vitamin D 81-90 interferon gamma Homo sapiens 24-40 28536054-6 2017 We observed a decreased interferon-gamma (IFNgamma) secretion by CD4+ T cells in vitamin D deficient group but not in the sufficient group, and a negative correlation between baseline serum vitamin D and IFNgamma production. Vitamin D 81-90 interferon gamma Homo sapiens 42-50 28536054-6 2017 We observed a decreased interferon-gamma (IFNgamma) secretion by CD4+ T cells in vitamin D deficient group but not in the sufficient group, and a negative correlation between baseline serum vitamin D and IFNgamma production. Vitamin D 190-199 interferon gamma Homo sapiens 204-212 28536054-8 2017 Increasing serum levels of 25-hydroxyvitamin D are associated with decreased production of IFNgamma by CD4+ T cells. 25-hydroxyvitamin D 27-46 interferon gamma Homo sapiens 91-99 28759590-5 2017 In contrast, the cytokine profile of Mtb-specific CD4 T cells of TB patients from SA was dominated by single IFN-gamma and dual IFN-gamma/TNF-alpha and associated with TB-induced systemic inflammation and elevated serum levels of type I IFNs. Terbium 65-67 interferon gamma Homo sapiens 128-137 28754958-5 2017 More importantly, tofacitinib significantly antagonized the ability of TNFalpha, IFNgamma and GM-CSF to boost human PMNs in phagocytosis and direct killing of C. albicans in vitro. tofacitinib 18-29 interferon gamma Homo sapiens 81-89 28754958-6 2017 It also down-regulated reactive oxygen production and neutrophil extracellular trap formation by human PMNs stimulated with yeast-derived beta-glucans in the presence of TNFalpha, IFNgamma or GM-CSF. beta-Glucans 138-150 interferon gamma Homo sapiens 180-188 28512255-11 2017 Decrease in CCL4 as well as IFNgamma with penfluridol treatment was also observed indicating decrease in overall tumor inflammation. Penfluridol 42-53 interferon gamma Homo sapiens 28-36 28198144-5 2017 The PE of EVOO decreased the frequency of CD69+ cells and the secretion of IFN-gamma, TNF-alpha, IL-6, IL-1beta, and IL-10. evoo 10-14 interferon gamma Homo sapiens 75-84 28673995-5 2017 Accordingly, a histone deacetylase inhibitor (HDACi) could reduce IPS in the state where IFN-gamma expression was suppressed by FK506. Tacrolimus 128-133 interferon gamma Homo sapiens 89-98 28729550-8 2017 The most active compound, tetrakis-pivaloyloxymethyl 2-(thiazole-2-ylamino)ethylidene-1,1- bisphosphonate (7), specifically expanded gammadelta T cells and stimulated them to secrete interferon-gamma and kill tumor cells. tetrakispivaloyloxymethyl 2-(thiazole-2-ylamino)ethylidene-1,1-bisphosphonate 26-105 interferon gamma Homo sapiens 183-199 28193627-9 2017 IFNgamma responses to alpha-galactosylceramide were increased in PBMCs from some patients after infusions, and delayed-type hypersensitivity responses to Candida increased in 5 of 8 evaluated patients. alpha-galactosylceramide 22-46 interferon gamma Homo sapiens 0-8 28747916-0 2017 Interferon-Gamma DNA Methylation Is Affected by Mycophenolic Acid but Not by Tacrolimus after T-Cell Activation. Mycophenolic Acid 48-65 interferon gamma Homo sapiens 0-16 28582842-2 2017 Neopterin, which is secreted by interferon-gamma stimulated macrophages, exhibits an association with multiple cancer types and metastatic disease. Neopterin 0-9 interferon gamma Homo sapiens 32-48 28747916-4 2017 Here, we determined the effect of tacrolimus and MPA on DNA methylation of the gene promoter region of interferon gamma (IFNgamma), a pro-inflammatory cytokine. Tacrolimus 34-44 interferon gamma Homo sapiens 103-130 28747916-12 2017 IFNgamma protein production was suppressed by tacrolimus. Tacrolimus 46-56 interferon gamma Homo sapiens 0-8 28347830-7 2017 RESULTS: In human keratinocytic HaCaT cells, PS extract inhibited the production of IL-8, and TARC, which had been increased by TNF-alpha and IFN-gamma. ps 45-47 interferon gamma Homo sapiens 142-151 28758106-4 2017 Neopterin synthesis is induced by interferon-gamma that also induces indoleamine 2,3-dioxygenase (IDO), an enzyme catalyzing catabolism of tryptophan to kynurenine. Neopterin 0-9 interferon gamma Homo sapiens 34-50 28903404-8 2017 Further, tHSCs-stimulated mDCs induced T-cell hypo-responsiveness, leading to decreased cytotoxic T lymphocyte (CTL) activity and reduced IFN-gamma production in splenic T cells. thscs 9-14 interferon gamma Homo sapiens 138-147 28362657-4 2017 RECENT FINDINGS: Multiple environmental factors (trichloroethylene, breast milk, and vitamin C) initiate aberrant epigenetic modifications in CD4 T cells, leading to a list of transcriptional deregulations in several genes (Ifng, Cd70, Tnf, Dnmt3a, and Foxp3) that determine T-cell identity. Trichloroethylene 49-66 interferon gamma Homo sapiens 224-228 28362657-4 2017 RECENT FINDINGS: Multiple environmental factors (trichloroethylene, breast milk, and vitamin C) initiate aberrant epigenetic modifications in CD4 T cells, leading to a list of transcriptional deregulations in several genes (Ifng, Cd70, Tnf, Dnmt3a, and Foxp3) that determine T-cell identity. Ascorbic Acid 85-94 interferon gamma Homo sapiens 224-228 28758106-4 2017 Neopterin synthesis is induced by interferon-gamma that also induces indoleamine 2,3-dioxygenase (IDO), an enzyme catalyzing catabolism of tryptophan to kynurenine. Tryptophan 139-149 interferon gamma Homo sapiens 34-50 28758106-4 2017 Neopterin synthesis is induced by interferon-gamma that also induces indoleamine 2,3-dioxygenase (IDO), an enzyme catalyzing catabolism of tryptophan to kynurenine. Kynurenine 153-163 interferon gamma Homo sapiens 34-50 28501767-9 2017 In addition, DATS treatment evidently increased the cytokine secretions of IL-12, TNF-alpha and IFN-gamma (p<0.05). diallyl trisulfide 13-17 interferon gamma Homo sapiens 96-105 28412245-7 2017 However, after PMA + ionomycin stimulation, the degranulation and TNFalpha expression by CXCR5+CD8+ T cells were significantly elevated to a level comparable with CXCR5-CD8+ T cells, whereas the IFNgamma expression by PMA + ionomycin-stimulated CXCR5+CD8+ T cells were significantly higher than that by CXCR5-CD8+ T cells. Ionomycin 21-30 interferon gamma Homo sapiens 195-203 28412245-7 2017 However, after PMA + ionomycin stimulation, the degranulation and TNFalpha expression by CXCR5+CD8+ T cells were significantly elevated to a level comparable with CXCR5-CD8+ T cells, whereas the IFNgamma expression by PMA + ionomycin-stimulated CXCR5+CD8+ T cells were significantly higher than that by CXCR5-CD8+ T cells. Ionomycin 224-233 interferon gamma Homo sapiens 195-203 28385330-14 2017 CONCLUSIONS: These results demonstrate a H2O2-involved autoimmune phenotype in vitiligo and halo nevus, characterized by increased level of IFN-gamma-inducible chemokine pair CXCL10-CXCR3, as well as a dense CD8+ T infiltration in the skin lesions, thus suggesting a similar pathogenesis of the two diseases. Hydrogen Peroxide 41-45 interferon gamma Homo sapiens 140-149 31966579-10 2017 However, ROSI treatment resulted in decreased interferon-gamma and increased interleukin-10 levels after stenting. rosiglitazonermsf 9-13 interferon gamma Homo sapiens 46-62 28735627-7 2017 We have previously demonstrated that AA and the prostaglandin metabolite, PGD2, repressed the IFNgamma mediated activity of IDO-1 in THP-1 cells and human monocytes. Prostaglandins 48-61 interferon gamma Homo sapiens 94-102 28839362-7 2017 The methanol extracts of seeds also demonstrated the highest inhibition of TNF-alpha, IL-1beta, IL-6, and IFN-gamma production. Methanol 4-12 interferon gamma Homo sapiens 106-115 28236206-19 2017 It is postulated herein that the detrimental activation of autoimmune T cells by glutamate in MS could lead to: (1) Cytotoxicity in the CNS: T cell-mediated killing of neurons and glia cells, which would subsequently increase the extracellular glutamate levels, and by doing so increase the excitotoxicity mediated by excess glutamate, (2) Release of proinflammatory cytokines, e.g., TNFalpha and IFNgamma that increase neuroinflammation. Glutamic Acid 81-90 interferon gamma Homo sapiens 397-405 28444390-11 2017 Isoniazid which did not induce significant hepatocyte toxicity, compared with SMX-NO and flucloxacillin, stimulated the release of a panel of cytokines including the above and IFN-gamma, IL-12, IL-17A, IP-10, and IL-10. Isoniazid 0-9 interferon gamma Homo sapiens 176-185 28581445-8 2017 Thus, glutamine may enhance the IFN-gamma-associated immune response and reduce the rate of reactivation of latent virus infection. Glutamine 6-15 interferon gamma Homo sapiens 32-41 28665310-7 2017 The ArtinM effect on aberrantly-glycosylated neoplastic lymphocytes was studied in Jurkat T cells, in which ArtinM induced IL-2, IFN-gamma, and IL-1beta production, but decreased cell viability and growth. artinm 108-114 interferon gamma Homo sapiens 129-138 28665978-5 2017 In this study we investigated whether the testosterone reduces the prostatitis and related mechanism by regulating IFN-gamma/STAT1 signaling pathway. Testosterone 42-54 interferon gamma Homo sapiens 115-124 28713392-3 2017 Here, we show that IL-15-stimulated TEMRA from kidney-transplant (KT) recipients promote inflammation by inducing the expression of CX3CL1 by endothelial cells in an IFN-gamma- and TNF-alpha-dependent manner. temra 36-41 interferon gamma Homo sapiens 166-175 28657598-7 2017 Furthermore, in PFCs, Gal-9 alone could stimulate IFN-gamma synthesis in culture or ELISPOT, which was inhibited by a Gal-9 antagonist lactose, and which may promote apoptosis and necrosis. Lactose 135-142 interferon gamma Homo sapiens 50-59 28645309-13 2017 CD4+ and CD8+ T cell populations isolated from the OB during latency were capable of responding to PMA/ionomycin in the production of IFN-gamma similar to T cells from other tissue that possess latent virus including the TG and brain stem. Tetradecanoylphorbol Acetate 99-102 interferon gamma Homo sapiens 134-143 28658262-4 2017 Comparing IL-4 generated in vitro monocyte derived human AAMs to LPS and IFN-gamma generated classically macrophages (CAMs), both infected with mycobacteria (BCG), we demonstrated increased early BCG uptake and increased IL-10 production in AAMs compared to CAMs. cams 118-122 interferon gamma Homo sapiens 73-82 28702457-5 2017 This cytokine profile was observed together with reduced expression of IFN-gamma by MM RPMI 8226 cell line, a determinant interleukin involved in the acquisition of cellular-mediated protective responses against tumor cells. rpmi 87-91 interferon gamma Homo sapiens 71-80 28645309-13 2017 CD4+ and CD8+ T cell populations isolated from the OB during latency were capable of responding to PMA/ionomycin in the production of IFN-gamma similar to T cells from other tissue that possess latent virus including the TG and brain stem. Ionomycin 103-112 interferon gamma Homo sapiens 134-143 28514139-5 2017 A bioorthogonal conjugation approach is used to conjugate an anti-IFN-gamma antibody with a GLuc mutant containing the N-terminal tyrosine using formylbenzene diazonium hexafluorophosphate reagent (FBDP) in hydrophilic mild pH environment yielding high conjugation efficiency (60%). Tyrosine 130-138 interferon gamma Homo sapiens 66-75 28665937-9 2017 CYP24a1 silencing plus treatment with 25 and/or 1,25 vitamin D had an additional reduction effect on IL-6, IFN-gamma, TLR7 and TLR9 expression. Vitamin D 53-62 interferon gamma Homo sapiens 107-116 28514139-5 2017 A bioorthogonal conjugation approach is used to conjugate an anti-IFN-gamma antibody with a GLuc mutant containing the N-terminal tyrosine using formylbenzene diazonium hexafluorophosphate reagent (FBDP) in hydrophilic mild pH environment yielding high conjugation efficiency (60%). formylbenzene diazonium hexafluorophosphate 145-188 interferon gamma Homo sapiens 66-75 28507026-8 2017 Surprisingly, we found that an inhibitor of GAPDH, 3-bromopyruvic acid (3-BrPa), blocks IFN-gamma, but not IL-17A, production in immune cells isolated from the EAE CNS. bromopyruvate 51-70 interferon gamma Homo sapiens 88-97 28507026-8 2017 Surprisingly, we found that an inhibitor of GAPDH, 3-bromopyruvic acid (3-BrPa), blocks IFN-gamma, but not IL-17A, production in immune cells isolated from the EAE CNS. bromopyruvate 72-78 interferon gamma Homo sapiens 88-97 28507026-9 2017 Indeed, in vitro studies confirmed that the production of IFN-gamma by differentiated Th1 cells is more sensitive to 3-BrPa than is the production of IL-17A by Th17 cells. bromopyruvate 117-123 interferon gamma Homo sapiens 58-67 28520912-2 2017 In vitro studies demonstrate that Ct growth inhibition occurs by interferon-gamma (IFN-gamma)-mediated depletion of intracellular tryptophan, and some Ct strains utilize extracellular indole to restore tryptophan levels. Tryptophan 130-140 interferon gamma Homo sapiens 65-81 28520912-2 2017 In vitro studies demonstrate that Ct growth inhibition occurs by interferon-gamma (IFN-gamma)-mediated depletion of intracellular tryptophan, and some Ct strains utilize extracellular indole to restore tryptophan levels. Tryptophan 130-140 interferon gamma Homo sapiens 83-92 28520912-2 2017 In vitro studies demonstrate that Ct growth inhibition occurs by interferon-gamma (IFN-gamma)-mediated depletion of intracellular tryptophan, and some Ct strains utilize extracellular indole to restore tryptophan levels. Tryptophan 202-212 interferon gamma Homo sapiens 83-92 28642841-12 2017 The in vitro IFN-gamma production by TLA-stimulated PBMCs was correlated with the infection dose and predominantly brought about by CD3+CD4-CD8alphabright T-lymphocytes. tartaric acid 37-40 interferon gamma Homo sapiens 13-22 28327343-6 2017 Astilbin also increased the TER value in Caco-2 cells co-stimulated with TNF-alpha plus IFN-gamma, and moreover upregulated the protein expression of TJ-related molecules in Caco-2 cells co-treated with TNF-alpha plus IFN-gamma. astilbin 0-8 interferon gamma Homo sapiens 88-97 28497690-5 2017 IFN-gamma-antibody (Ab)1 and IL-2-Ab1 were separately immobilized on the two sensing areas to capture the corresponding LTBI markers, which were further recognized by IFN-gamma-Ab2 and IL-2-Ab2 labeled as MB@Au@CQDs and MB@Au@luminol. Luminol 226-233 interferon gamma Homo sapiens 0-9 28327343-6 2017 Astilbin also increased the TER value in Caco-2 cells co-stimulated with TNF-alpha plus IFN-gamma, and moreover upregulated the protein expression of TJ-related molecules in Caco-2 cells co-treated with TNF-alpha plus IFN-gamma. astilbin 0-8 interferon gamma Homo sapiens 218-227 28448894-2 2017 METHODS: We analyzed the ability of IL-33 treated Tregs to inhibit the production of IFN-gamma by effector T lymphocytes in an in vitro co-culture. tregs 50-55 interferon gamma Homo sapiens 85-94 28431214-0 2017 Interferon-gamma Released by Activated CD8+ T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves. Calcium 70-77 interferon gamma Homo sapiens 0-16 28431214-6 2017 The stimulation of tissue with phorbol-12-myristate-13-acetate and ionomycin, recapitulating CAVD microenvironment, resulted in IFN-gamma release. Tetradecanoylphorbol Acetate 31-62 interferon gamma Homo sapiens 128-137 28431214-6 2017 The stimulation of tissue with phorbol-12-myristate-13-acetate and ionomycin, recapitulating CAVD microenvironment, resulted in IFN-gamma release. Ionomycin 67-76 interferon gamma Homo sapiens 128-137 28587282-1 2017 The purpose of this study is to determine if a preventive treatment with curcumin can protect intestinal epithelial cells from inflammatory damage induced by IFNgamma. Curcumin 73-81 interferon gamma Homo sapiens 158-166 28587282-3 2017 In this model, we measured the effect of curcumin (curcuminoid from Curcuma Longa) added as a pre-treatment at different time intervals before stimulation with IFNgamma. Curcumin 41-49 interferon gamma Homo sapiens 160-168 28587282-4 2017 Curcumin administration to HT29 culture before the inflammatory stimulus IFNgamma reduced the cell apoptosis rate. Curcumin 0-8 interferon gamma Homo sapiens 73-81 28241397-6 2017 DCs seeded on beta-TCP showed a decrease in co-stimulatory molecules (CD86 and CD40) and pro-inflammatory gene IFN-gamma but an increase in anti-inflammatory genes including IL-1ra, IL-4, and IL-10, as well as TGF-beta1. beta-tricalcium phosphate 14-22 interferon gamma Homo sapiens 111-120 28249842-7 2017 Following standard antituberculosis (anti-TB) treatment, we observed alterations in the baseline and/or antigen-specific levels of IFN-gamma, TNF-alpha, IL-1beta, and IL-18. Terbium 42-44 interferon gamma Homo sapiens 131-140 28620394-0 2017 Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNgamma Secretion. Vitamin D 0-9 interferon gamma Homo sapiens 139-147 28620394-4 2017 Paradoxically, vitamin D has repeatedly been ascribed an immune-suppressive function inhibiting Th1 differentiation and production of IFNgamma in T cells. Vitamin D 15-24 interferon gamma Homo sapiens 134-142 28620394-7 2017 We show that vitamin D does not block differentiation of human CD4+ T cells to Th1 cells and that interleukin (IL)-12 partially counteracts vitamin D-mediated inhibition of IFNgamma production promoting production of equal amounts of IFNgamma in Th1 cells in the presence of vitamin D as in T cells activated in the absence of vitamin D and IL-12. Vitamin D 140-149 interferon gamma Homo sapiens 173-181 28620394-7 2017 We show that vitamin D does not block differentiation of human CD4+ T cells to Th1 cells and that interleukin (IL)-12 partially counteracts vitamin D-mediated inhibition of IFNgamma production promoting production of equal amounts of IFNgamma in Th1 cells in the presence of vitamin D as in T cells activated in the absence of vitamin D and IL-12. Vitamin D 140-149 interferon gamma Homo sapiens 173-181 28620394-7 2017 We show that vitamin D does not block differentiation of human CD4+ T cells to Th1 cells and that interleukin (IL)-12 partially counteracts vitamin D-mediated inhibition of IFNgamma production promoting production of equal amounts of IFNgamma in Th1 cells in the presence of vitamin D as in T cells activated in the absence of vitamin D and IL-12. Vitamin D 140-149 interferon gamma Homo sapiens 173-181 28620394-9 2017 In conclusion, we demonstrate that vitamin D counteracts M. tuberculosis-induced cathelicidin downregulation and allows Th1 differentiation and IFNgamma secretion. Vitamin D 35-44 interferon gamma Homo sapiens 144-152 28493883-5 2017 We found that unconjugated lithocholic acid (LCA) impedes Th1 activation as measured by i) decreased production of the Th1 cytokines IFNgamma and TNFalphaalpha, ii) decreased expression of the Th1 genes T-box protein expressed in T cells (T-bet), Stat-1 and Stat4, and iii) decreased STAT1alpha/beta phosphorylation. Lithocholic Acid 27-43 interferon gamma Homo sapiens 133-141 28493883-5 2017 We found that unconjugated lithocholic acid (LCA) impedes Th1 activation as measured by i) decreased production of the Th1 cytokines IFNgamma and TNFalphaalpha, ii) decreased expression of the Th1 genes T-box protein expressed in T cells (T-bet), Stat-1 and Stat4, and iii) decreased STAT1alpha/beta phosphorylation. Lithocholic Acid 45-48 interferon gamma Homo sapiens 133-141 28511637-7 2017 cITP patients with the IFN-gamma +874 non-AA genotype (high expression type) showed more severe thrombocytopenia than those with the AA genotype (P < 0.05). citp 0-4 interferon gamma Homo sapiens 23-32 28404635-3 2017 In this article, we show that miR-24 drives the production of IFN-gamma and IL-17 in T cells at least in part through targeting TCF1, a transcription factor known for its role in limiting Th1 and Th17 immunity. mir-24 30-36 interferon gamma Homo sapiens 62-71 27838757-5 2017 Key genes regulating the immune system, such as tumor necrosis factor alpha and interferon gamma, as well as genes related to the NF-kappa-beta complex, were significantly downregulated in the high-arsenic group. Arsenic 198-205 interferon gamma Homo sapiens 80-96 28622776-6 2017 On the other hand, iron affect innate immune responses by influencing IFN-gamma or NF-kB pathways in macrophages. Iron 19-23 interferon gamma Homo sapiens 70-79 27715403-8 2017 Doses of 10 and 100 nM calcitriol also significantly decreased the inflammatory cytokine IFN-gamma in the TL-1 cell line. Calcitriol 23-33 interferon gamma Homo sapiens 89-98 28215653-7 2017 RESULTS: Our data show that gmDCs significantly stimulated the expansion of co-cultured CIKs and increased the secretion of interferon-gamma and interleukin-12. gmdcs 28-33 interferon gamma Homo sapiens 124-140 28240768-6 2017 In the LPS model of pulmonary inflammation, eucalyptol treatment diminished leukocyte infiltration, myeloperoxidase activity and production of TNF-alpha, IL-1beta, IFN-gamma and IL-6. Eucalyptol 44-54 interferon gamma Homo sapiens 164-173 28383326-1 2017 OBJECTIVE: In this study, we investigated the correlation between serum and urinary neopterin levels as well as the stage of the disease in women with endometrial cancer.Increased neopterin concentrations are reported in patients with activation of macrophages by interferon-gamma, which includes the following: viral infections, autoimmune disorders, allograft rejection, and various malignant tumors. Neopterin 180-189 interferon gamma Homo sapiens 264-280 28350110-2 2017 Thus, the aim of this study was to investigate whether the severity of MeHg- and HgCl2-mediated cytotoxicity to SH-SY5Y human dopaminergic neurons can be attenuated by regulating glutamate-mediated signal-transmission through caffeine and interferon-gamma (IFN-gamma). Glutamic Acid 179-188 interferon gamma Homo sapiens 257-266 28350110-10 2017 IFN-gamma treatment decreased cell viability and increased oxidative stress in glutamine-free medium, despite caffeine supplementation. Glutamine 79-88 interferon gamma Homo sapiens 0-9 28350110-10 2017 IFN-gamma treatment decreased cell viability and increased oxidative stress in glutamine-free medium, despite caffeine supplementation. Caffeine 110-118 interferon gamma Homo sapiens 0-9 27542662-11 2017 Stimulation with lipopolysaccharide (LPS) or interferon-gamma upregulated HDC-gene transcript in HOKs, whereas this was downregulated with high histamine concentration and tumour necrosis factor-alpha. Histamine 144-153 interferon gamma Homo sapiens 45-61 28350110-0 2017 Glutamate-mediated effects of caffeine and interferon-gamma on mercury-induced toxicity. Glutamic Acid 0-9 interferon gamma Homo sapiens 43-59 28350110-11 2017 Although caffeine exerted a protective effect against MeHg-induced toxicity with glutamate transmission, under co-stimulation with glutamine and IFN-gamma, caffeine decreased the MeHg-induced average oxidative stress only by half. Caffeine 156-164 interferon gamma Homo sapiens 145-154 28350110-0 2017 Glutamate-mediated effects of caffeine and interferon-gamma on mercury-induced toxicity. Mercury 63-70 interferon gamma Homo sapiens 43-59 28199730-9 2017 Secretions of IFN-gamma, IL-2 and IL-4 cytokines were significantly decreased by moderate to high dose of fentanyl compared with controls. Fentanyl 106-114 interferon gamma Homo sapiens 14-23 28350110-2 2017 Thus, the aim of this study was to investigate whether the severity of MeHg- and HgCl2-mediated cytotoxicity to SH-SY5Y human dopaminergic neurons can be attenuated by regulating glutamate-mediated signal-transmission through caffeine and interferon-gamma (IFN-gamma). Glutamic Acid 179-188 interferon gamma Homo sapiens 239-255 27623446-5 2017 RESULTS: SF enhanced naive CD4+ T cell proliferation and IFN-gamma/IL-17 production in cell-contact and in part ICAM-1-/VCAM-1-dependent manner. sf 9-11 interferon gamma Homo sapiens 57-66 28350110-12 2017 Thereby, our data indicate that the IFN-gamma stimulation of mercury-exposed dopaminergic neurons in neuroinflammatory diseases may diminish the neuroprotective effects of caffeine. Mercury 61-68 interferon gamma Homo sapiens 36-45 28350110-12 2017 Thereby, our data indicate that the IFN-gamma stimulation of mercury-exposed dopaminergic neurons in neuroinflammatory diseases may diminish the neuroprotective effects of caffeine. Caffeine 172-180 interferon gamma Homo sapiens 36-45 27943400-5 2017 The injection of HMGB1 into the IMQ-treated skin further aggravated the psoriasis-like disease, enhanced the infiltration of CD3+ T cells, myeloperoxidase+ neutrophils and CD11c+ dendritic cells, increased the number of gammadelta T cells, and upregulated the mRNA expression of interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma and IL-17 compared with the PBS injection. Imiquimod 32-35 interferon gamma Homo sapiens 334-356 28881647-8 2017 An inhibition of Th1/Th17 responses was observed as evidenced by a decreased production of IFN-gamma, IL-17, and a reduction of IFN-gamma/IL-17- producing CD4+ T cells following treatment with DAC. Decitabine 193-196 interferon gamma Homo sapiens 91-100 28881647-8 2017 An inhibition of Th1/Th17 responses was observed as evidenced by a decreased production of IFN-gamma, IL-17, and a reduction of IFN-gamma/IL-17- producing CD4+ T cells following treatment with DAC. Decitabine 193-196 interferon gamma Homo sapiens 128-137 28469791-9 2017 The results also revealed that Foxp3 bound T-bet to prevent IFN-gamma expression in CD4+ T cells, which was abolished by treating with curcumin. Curcumin 135-143 interferon gamma Homo sapiens 60-69 28469791-10 2017 In conclusion, the administration of curcumin can convert Tregs to Th1 cells via repressing Foxp3 expression and enhancing IFN-gamma production. Curcumin 37-45 interferon gamma Homo sapiens 123-132 28410411-12 2017 Furthermore, BILN-2061-treatment significantly increased degranulation against K-562 target cells and IFN-gamma productivity in NK cells. biln 13-17 interferon gamma Homo sapiens 102-111 28258191-7 2017 A corresponding increase in IL-4 and decrease in IFN-gamma and IL-17-expressing CD4+ T cells were observed in DMF-treated patients. Dimethyl Fumarate 110-113 interferon gamma Homo sapiens 49-58 28284336-2 2017 Here we show that PAR treatment inhibits the initiation of experimental autoimmune neuritis (EAN), suppresses the production of TNF-alpha, IFN-gamma, IL-1beta and IL-17, and decreases Th1 and Th17 cells at early time point. parthenolide 18-21 interferon gamma Homo sapiens 139-148 28242320-6 2017 Moreover, both aminoguanidine (AG, a selective inhibitor of iNOS) and diethyldithiocarbamate (DDC, a nuclear factor-kappa B (NFkappaB) inhibitor) attenuated these changes in IFN-gamma and LPS stimulated HLE cells. pimagedine 15-29 interferon gamma Homo sapiens 174-183 28242320-6 2017 Moreover, both aminoguanidine (AG, a selective inhibitor of iNOS) and diethyldithiocarbamate (DDC, a nuclear factor-kappa B (NFkappaB) inhibitor) attenuated these changes in IFN-gamma and LPS stimulated HLE cells. Ditiocarb 70-92 interferon gamma Homo sapiens 174-183 28242320-6 2017 Moreover, both aminoguanidine (AG, a selective inhibitor of iNOS) and diethyldithiocarbamate (DDC, a nuclear factor-kappa B (NFkappaB) inhibitor) attenuated these changes in IFN-gamma and LPS stimulated HLE cells. Zalcitabine 94-97 interferon gamma Homo sapiens 174-183 28384236-6 2017 As a result, 85 novel genes were inferred, among which eleven genes (e.g., MYD88, FGFR2, NF-kappaBIA) were identified by both the RWR-based and SP-based methods, 70 genes (e.g., BMP4, IFNG, KITLG) were discovered only by the RWR-based method and four genes (L1R1, MCM6, NOG and CXCR3) were predicted only by the SP-based method. TFF2 protein, human 144-146 interferon gamma Homo sapiens 184-188 28406139-4 2017 Here we show that Itk negatively regulates the development of nTh1 cells that express IFNgamma in a Tbet independent manner, and whose expansion can be enhanced by IL4. tbet 100-104 interferon gamma Homo sapiens 86-94 28638744-5 2017 Further, AZA significantly decreased human T-cell proliferation as well as IFNgamma and TNF-alpha serum levels, and reduced the expression of GRANZYME B and PERFORIN 1 by cytotoxic T cells. Azacitidine 9-12 interferon gamma Homo sapiens 75-83 27984757-9 2017 Animals treated with UA had less parasites in the spleen and liver when compared with the infected control group, and they also showed preservation of white and red pulps, which correlate with a high rate of proliferation of splenic mononuclear cells, IFN-gamma mRNA and iNOS production. ursolic acid 21-23 interferon gamma Homo sapiens 252-261 28054352-11 2017 We found up-regulation of IFN-gamma in children with elevated serum total IgE levels carrying the Arg130 allele (P = 0 005). DL-Arginine 98-104 interferon gamma Homo sapiens 26-35 28601051-1 2017 Oryzatensin (ORZ) can reduce potentially IFN-gamma secretion by natural killer (NK) cells. oryzatensin 0-11 interferon gamma Homo sapiens 41-50 28601051-1 2017 Oryzatensin (ORZ) can reduce potentially IFN-gamma secretion by natural killer (NK) cells. oryzatensin 13-16 interferon gamma Homo sapiens 41-50 28157399-5 2017 After PMA+ionomycin stimulation, CXCR5+ CD8+ T cells from CHB patients presented significantly higher transcription level of interferon gamma (IFN-gamma), interleukin 10 (IL-10), and IL-21, as well as higher IL-10 and IL-21 protein secretion, than CXCR5- CD8+ T cells. Ionomycin 10-19 interferon gamma Homo sapiens 125-152 28094124-9 2017 The higher interferon-gamma values in collection tubes (tuberculosis antigen tube and/or negative control tube) resulted in higher QuantiFERON-TB gold in-tube positivity rate. tb gold 143-150 interferon gamma Homo sapiens 11-27 28094124-10 2017 The distribution of interferon-gamma in tuberculosis antigen tube and negative control tube, as evaluated by median and interquartile range, proved to be an effective index for the quality control of QuantiFERON-TB gold in-tube. tb gold 212-219 interferon gamma Homo sapiens 20-36 28422864-12 2017 CONCLUSION: In conclusion, we confirmed that just as morphine, ketamine dose-dependently suppressed IL-2 and IFN-gamma of activated T lymphocyte of patients with refractory cancer pain in vitro, but the inhibitory action of low dose ketamine could be neglected. Ketamine 63-71 interferon gamma Homo sapiens 109-118 27888289-5 2017 Upon exposure to a classical AhR ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), selective induction of CCL1 was noted only in M(IL-4), not M(IFN-gamma/LPS) cells in human but not murine macrophages. Polychlorinated Dibenzodioxins 41-76 interferon gamma Homo sapiens 146-155 27888289-5 2017 Upon exposure to a classical AhR ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), selective induction of CCL1 was noted only in M(IL-4), not M(IFN-gamma/LPS) cells in human but not murine macrophages. Polychlorinated Dibenzodioxins 78-82 interferon gamma Homo sapiens 146-155 28215501-2 2017 We aimed to investigate the relation between QuantiFERON-TB Gold In-Tube (QFT) conversion interferon-gamma values and risk of subsequent active tuberculosis disease and of QFT reversion. tb gold 57-64 interferon gamma Homo sapiens 90-106 28422864-0 2017 Ketamine, as adjuvant analgesics for patients with refractory cancer pain, does affect IL-2/IFN-gamma expression of T cells in vitro? Ketamine 0-8 interferon gamma Homo sapiens 92-101 28422864-4 2017 The current study was performed to assess whether the concentration of ketamine, as adjuvant analgesics for patient with refractory cancer pain, was related to its effect on T cells interleukin-2 (IL-2)/interferon-gamma (IFN-gamma) expression in vitro. Ketamine 71-79 interferon gamma Homo sapiens 203-219 28422864-4 2017 The current study was performed to assess whether the concentration of ketamine, as adjuvant analgesics for patient with refractory cancer pain, was related to its effect on T cells interleukin-2 (IL-2)/interferon-gamma (IFN-gamma) expression in vitro. Ketamine 71-79 interferon gamma Homo sapiens 221-230 28179527-8 2017 For granzyme B, Tat/Rev was the most dominant whereas for IFN-gamma, Gag predominated. Glycosaminoglycans 69-72 interferon gamma Homo sapiens 58-67 28396660-11 2017 As expected, Mphi-IFN-gamma showed significant production of ROS after FcgammaRI-, FcgammaRII-, or CD13-mediated phagocytosis. Reactive Oxygen Species 61-64 interferon gamma Homo sapiens 18-27 28333940-6 2017 At 20 WPV, the most significant transcriptional changes of Gag-specific CD8+ T cells were genes involved in TCR signaling, differentiation and maturation toward central memory cells, with increased expression of CCR7, TCRalpha, TCRbeta, CD28 and decreased expression of CTLA-4, IFN-gamma, RANTES, granzyme A and B. Glycosaminoglycans 59-62 interferon gamma Homo sapiens 278-287 28331190-9 2017 Moreover, we found that IFN-gamma production from NK cells was essential for the antiviral effect of PolyI:C in the model. Poly C 101-108 interferon gamma Homo sapiens 24-33 28065853-7 2017 Sitagliptin treatment not only inhibited IL-10 (p<0.05) and IFN-gamma (p=0.07) cytokines, but also completely abolish IL-6 expression by PBMCs (p<0.001). Sitagliptin Phosphate 0-11 interferon gamma Homo sapiens 63-72 28065853-10 2017 Sitagliptin treatment induced a significantly (p<0.05) decrease in IL-17 and IFN-gamma intracellular expression compared with PHA alone. Sitagliptin Phosphate 0-11 interferon gamma Homo sapiens 80-89 28303368-5 2017 Although tramadol did not alter resting macrophages and the antigen-presenting function in lipopolysaccharide-activated macrophages, it regulated M1 and M2 macrophages, which are, respectively, transformed by IFN-gamma and IL-4. Tramadol 9-17 interferon gamma Homo sapiens 209-218 28174303-4 2017 Interestingly, IFNgamma-induced tyrosine phosphorylation of STAT1 is reduced in cells with targeted disruption of Sin1, leading to decreased transcription of several IFNgamma-inducible genes in an mTORC2-independent manner. Tyrosine 32-40 interferon gamma Homo sapiens 15-23 28174303-4 2017 Interestingly, IFNgamma-induced tyrosine phosphorylation of STAT1 is reduced in cells with targeted disruption of Sin1, leading to decreased transcription of several IFNgamma-inducible genes in an mTORC2-independent manner. Tyrosine 32-40 interferon gamma Homo sapiens 166-174 27714313-5 2017 There are several shared effects of vitamin D and UVR on T cells including inhibition of proliferation and suppression of IFN-gamma and IL-17 producing T cells. Vitamin D 36-45 interferon gamma Homo sapiens 122-131 27362407-10 2017 When the cytokine levels were divided into quartiles, lower folate and vitamin B6 intake was associated with the highest levels of IL-4 in neonatal cord blood (p<0.05), and higher folate and vitamin B6 intake was associated with highest levels of IFN-gamma in neonatal cord blood. Folic Acid 60-66 interferon gamma Homo sapiens 250-259 28278166-4 2017 Starting April 2009, patients were given isoniazid (INH) prophylaxis based on interferon-gamma release assay results. Isoniazid 41-50 interferon gamma Homo sapiens 78-94 27362407-10 2017 When the cytokine levels were divided into quartiles, lower folate and vitamin B6 intake was associated with the highest levels of IL-4 in neonatal cord blood (p<0.05), and higher folate and vitamin B6 intake was associated with highest levels of IFN-gamma in neonatal cord blood. Vitamin B 6 71-81 interferon gamma Homo sapiens 250-259 27362407-11 2017 CONCLUSIONS: In this study, a strong association between IL-4 and IFN-gamma levels in cord blood and the intake of folate and vitamin B6 was found, which indicates that food intake during pregnancy might have a strong influence on IL-4 and IFN-gamma levels in cord blood, to a greater extent than environmental factors. Folic Acid 115-121 interferon gamma Homo sapiens 66-75 27362407-11 2017 CONCLUSIONS: In this study, a strong association between IL-4 and IFN-gamma levels in cord blood and the intake of folate and vitamin B6 was found, which indicates that food intake during pregnancy might have a strong influence on IL-4 and IFN-gamma levels in cord blood, to a greater extent than environmental factors. Folic Acid 115-121 interferon gamma Homo sapiens 240-249 27362407-11 2017 CONCLUSIONS: In this study, a strong association between IL-4 and IFN-gamma levels in cord blood and the intake of folate and vitamin B6 was found, which indicates that food intake during pregnancy might have a strong influence on IL-4 and IFN-gamma levels in cord blood, to a greater extent than environmental factors. Vitamin B 6 126-136 interferon gamma Homo sapiens 66-75 28108630-5 2017 The macropinocytic uptake of nab-paclitaxel induced macrophage immunostimulatory (M1) cytokine expression and synergized with IFNgamma to promote inducible nitric oxide synthase expression in a TLR4-dependent manner. nab 29-32 interferon gamma Homo sapiens 126-134 28108630-5 2017 The macropinocytic uptake of nab-paclitaxel induced macrophage immunostimulatory (M1) cytokine expression and synergized with IFNgamma to promote inducible nitric oxide synthase expression in a TLR4-dependent manner. Paclitaxel 33-43 interferon gamma Homo sapiens 126-134 27838900-8 2017 On the other hand, IFN-gamma resulted in ROS generation, through H2O2 production, whereas pre-treatment with the ROS inhibitor NAC caused ROS inhibition and a significant decrease in the phosphorylation levels of AKT, ERK1/2, p38 and STAT1. Hydrogen Peroxide 65-69 interferon gamma Homo sapiens 19-28 27579780-9 2017 Additionally, pretreatment with resveratrol, a selective SIRT1 activator, abrogated IFN-gamma-induced HMGB1 translocation and its release. Resveratrol 32-43 interferon gamma Homo sapiens 84-93 27579780-10 2017 Moreover, IFN-gamma stimulates VSMC phenotypic modulation to an activated synthetic state characterized by the repression of SMC differentiation markers such as SM22alpha and calponin and the increase in cell motility. vsmc 31-35 interferon gamma Homo sapiens 10-19 27838900-0 2017 ROS mediates interferon gamma induced phosphorylation of Src, through the Raf/ERK pathway, in MCF-7 human breast cancer cell line. Reactive Oxygen Species 0-3 interferon gamma Homo sapiens 13-29 27838900-4 2017 In this study, we examined IFN-gamma effect on the phosphorylation levels of key signaling proteins, through ROS production, in the human breast cancer cell line MCF-7. Reactive Oxygen Species 109-112 interferon gamma Homo sapiens 27-36 27579780-11 2017 In contrast, blocking HMGB1 release or activity by resveratrol and HMGB1-neutralizing antibody prevents IFN-gamma-induced phenotypic modulation of VSMCs. vsmcs 147-152 interferon gamma Homo sapiens 104-113 27838900-11 2017 In summary, IFN-gamma signaling in MCF-7 cell line is ROS-dependent and follows the Src/Raf/ERK pathway whereas its signaling through the AKT pathway is highly dependent on NOX1. Reactive Oxygen Species 54-57 interferon gamma Homo sapiens 12-21 27838900-8 2017 On the other hand, IFN-gamma resulted in ROS generation, through H2O2 production, whereas pre-treatment with the ROS inhibitor NAC caused ROS inhibition and a significant decrease in the phosphorylation levels of AKT, ERK1/2, p38 and STAT1. Reactive Oxygen Species 41-44 interferon gamma Homo sapiens 19-28 28400837-5 2017 Moreover, IPE treatment upregulated iNOS gene expression in macrophages in a time- and dose-dependent manner and led to the production of nitric oxide in macrophages in the presence of IFNgamma. ipe 10-13 interferon gamma Homo sapiens 185-193 28400837-5 2017 Moreover, IPE treatment upregulated iNOS gene expression in macrophages in a time- and dose-dependent manner and led to the production of nitric oxide in macrophages in the presence of IFNgamma. Nitric Oxide 138-150 interferon gamma Homo sapiens 185-193 28092804-4 2017 In this study, through a high-throughput screening, we have identified a natural product ingenol 3,20 dibenzoate (IDB), an activator of tumor suppressor protein kinase C (PKC) isozymes, could increase the IFN-gamma production and degranulation by NK cells, especially when NK cells were stimulated by non-small lung cancer (NSCLC) cells. ingenol dibenzoate 89-112 interferon gamma Homo sapiens 205-214 27762732-9 2017 HMOBs treated with epithelial supernatant or recombinant IFN-gamma, concurrently with PGE2 stimulation, reduced RANKL, but not OPG, expression. Dinoprostone 86-90 interferon gamma Homo sapiens 57-66 28092804-4 2017 In this study, through a high-throughput screening, we have identified a natural product ingenol 3,20 dibenzoate (IDB), an activator of tumor suppressor protein kinase C (PKC) isozymes, could increase the IFN-gamma production and degranulation by NK cells, especially when NK cells were stimulated by non-small lung cancer (NSCLC) cells. ingenol dibenzoate 114-117 interferon gamma Homo sapiens 205-214 28092804-6 2017 Furthermore, PKC inhibitor, sotrastaurin abrogated IDB-induced IFN-gamma production, degranulation and cytotoxicity, but did not affect IFN-gamma production by NK cells without IDB treatment and NSCLC cell stimulation. sotrastaurin 28-40 interferon gamma Homo sapiens 63-72 28179491-1 2017 Background: During development of cardiovascular disease (CVD), interferon-gamma-mediated inflammation accelerates degradation of tryptophan into downstream metabolites. Tryptophan 130-140 interferon gamma Homo sapiens 64-80 28454292-8 2017 In the present study, the effectiveness of SP-E6E7m-KDEL for inducing an interferon-gamma antigen-specific, response and its therapeutic effect against tumors was demonstrated, which was as effective as immunization against those antigens fused to CRT. TFF2 protein, human 43-45 interferon gamma Homo sapiens 73-89 28024448-6 2017 Results indicated that exposure to PCP decreased IFNgamma secretion at the highest exposures (2.5 and 5 muM) and increased IFNgamma secretion at lower concentrations. Pentachlorophenol 35-38 interferon gamma Homo sapiens 49-57 28261276-9 2017 Intake of methyl donating nutrients including folate was positively associated LINE-1 methylation and negatively associated with IFNgamma CpG-186. Folic Acid 46-52 interferon gamma Homo sapiens 129-137 28110210-8 2017 rIL-12 treatment increases the levels of pStat4 in Tregs and IFN-gamma production. ril-12 0-6 interferon gamma Homo sapiens 61-70 28235040-11 2017 In gene expression analyses, 25(OH)D was associated with higher IL-37, vitamin A with higher IFN-gamma and vitamin E with less IL-28 (P < 0.05). Vitamin A 71-80 interferon gamma Homo sapiens 93-102 28024448-6 2017 Results indicated that exposure to PCP decreased IFNgamma secretion at the highest exposures (2.5 and 5 muM) and increased IFNgamma secretion at lower concentrations. Pentachlorophenol 35-38 interferon gamma Homo sapiens 123-131 28024448-9 2017 Exposure of each of the immune cell preparations to DDT caused increase in IFNgamma secretion. DDT 52-55 interferon gamma Homo sapiens 75-83 28024448-11 2017 The mechanism of PCP-induced increase in IFNgamma secretion appears to involve the p38 mitogen activated protein kinase (MAPK) pathway, based on loss of PCP stimulated increase when this pathway was inhibited. Pentachlorophenol 17-20 interferon gamma Homo sapiens 41-49 28024448-11 2017 The mechanism of PCP-induced increase in IFNgamma secretion appears to involve the p38 mitogen activated protein kinase (MAPK) pathway, based on loss of PCP stimulated increase when this pathway was inhibited. Pentachlorophenol 153-156 interferon gamma Homo sapiens 41-49 28231856-12 2017 After fingolimod, slanDCs demonstrated reduced potential to induce interferon-gamma-expressing Th1 or IL-17-expressing Th17 cells and DC-dependent T cell proliferation in vitro and in fingolimod-treated patients. slandcs 18-25 interferon gamma Homo sapiens 67-83 28260924-6 2017 RESULTS AND CONCLUSION: A significant increase of peripheral natural killer cells and interferon-gamma (INF-gamma) after 4 weeks of gefitinib treatment (P=0.005 and 0.02, respectively). Gefitinib 132-141 interferon gamma Homo sapiens 86-102 28225764-9 2017 Noteworthy, was the ability of TcI-antigen to drive a complex global pro-inflammatory network mediated by TNF and IFN-gamma from NK-cells, CD4+ and CD8+ T-cells, regulated by IL-10+CD8+ T-cells, in contrast to the TcIV-antigens that trigger a modest network, with moderate connecting edges. tci 31-34 interferon gamma Homo sapiens 114-123 28260924-6 2017 RESULTS AND CONCLUSION: A significant increase of peripheral natural killer cells and interferon-gamma (INF-gamma) after 4 weeks of gefitinib treatment (P=0.005 and 0.02, respectively). Gefitinib 132-141 interferon gamma Homo sapiens 104-113 28270799-4 2017 Our results suggested that even in the presence of OT and leukotrienes absence, cytokine IFN-gamma remains being secreted, which gives us an indication of immune system specificity and also that IFN-gamma participates in various immune processes. ot 51-53 interferon gamma Homo sapiens 195-204 28270799-4 2017 Our results suggested that even in the presence of OT and leukotrienes absence, cytokine IFN-gamma remains being secreted, which gives us an indication of immune system specificity and also that IFN-gamma participates in various immune processes. Leukotrienes 58-70 interferon gamma Homo sapiens 89-98 28270799-4 2017 Our results suggested that even in the presence of OT and leukotrienes absence, cytokine IFN-gamma remains being secreted, which gives us an indication of immune system specificity and also that IFN-gamma participates in various immune processes. Leukotrienes 58-70 interferon gamma Homo sapiens 195-204 28228217-7 2017 The levels of IFN-gamma were significantly higher in human macrophage U937 cells that were treated with T peptide alone or T peptide combined with cisplatinum; (2) In the xenograft mouse models, T peptide combined with cisplatinum treatment significantly inhibited tumor growth without weight loss compared with the other groups; (3) The percentages of macrophages in the peripheral blood were significantly higher in the xenograft mouse models that were treated with T peptide combined with cisplatinum compared with in the other groups. Cisplatin 147-158 interferon gamma Homo sapiens 14-23 28228217-7 2017 The levels of IFN-gamma were significantly higher in human macrophage U937 cells that were treated with T peptide alone or T peptide combined with cisplatinum; (2) In the xenograft mouse models, T peptide combined with cisplatinum treatment significantly inhibited tumor growth without weight loss compared with the other groups; (3) The percentages of macrophages in the peripheral blood were significantly higher in the xenograft mouse models that were treated with T peptide combined with cisplatinum compared with in the other groups. Cisplatin 219-230 interferon gamma Homo sapiens 14-23 28228217-7 2017 The levels of IFN-gamma were significantly higher in human macrophage U937 cells that were treated with T peptide alone or T peptide combined with cisplatinum; (2) In the xenograft mouse models, T peptide combined with cisplatinum treatment significantly inhibited tumor growth without weight loss compared with the other groups; (3) The percentages of macrophages in the peripheral blood were significantly higher in the xenograft mouse models that were treated with T peptide combined with cisplatinum compared with in the other groups. Cisplatin 219-230 interferon gamma Homo sapiens 14-23 28169371-3 2017 In this study, we aimed to discover potent anti-inflammatory compounds that suppress IFN-gamma production and found that the novel benzoxazole derivatives, 2-((3,4-dichlorophenyl) amino) benzo[d]xazol-5-ol (DCPAB) and 2-((3,4-hydroxyphenyl) amino) benzo[d]xazol-5-ol (HPAB), suppressed IFN-gamma production by T cells. Benzoxazoles 131-142 interferon gamma Homo sapiens 85-94 28231660-9 2017 Levels of IFN-gamma and IL-10 in telbivudine-treated group were higher than those in the controls (aRR=8.684, 95%CI: 1.977-38.140; aRR=5.330, 95% CI: 1.278-22.236). Telbivudine 33-44 interferon gamma Homo sapiens 10-19 28337387-7 2017 IFN-gamma levels were significantly lower (P = 0.04) in children with SMA (400 +- 200 pg/ml) than in those with uncomplicated malaria (900 +- 450 pg/ml) and higher in those with parasitemia (P = 0.019). sma 70-73 interferon gamma Homo sapiens 0-9 28198433-0 2017 A cyclometalated iridium(III) complex used as a conductor for the electrochemical sensing of IFN-gamma. iridium(iii) 17-29 interferon gamma Homo sapiens 93-102 28198433-1 2017 A novel iridium(III) complex was prepared and used as a conductor for sensitive and enzyme-free electrochemical detection of interferon gamma (IFN-gamma). iridium(iii) 8-20 interferon gamma Homo sapiens 125-152 28198433-4 2017 Subsequently, a loop-stem structured capture probe (CP) containing a special IFN-gamma interact strand was modified onto the (+)AuNP surface via the formation of Au-S bonds. aunp 128-132 interferon gamma Homo sapiens 77-86 28198433-7 2017 Meanwhile, the iridium(III) complex could interact with the grooves of the dsDNA polymer, producing a strong current signal that was proportional to IFN-gamma concentration. iridium(iii) 15-27 interferon gamma Homo sapiens 149-158 28231660-11 2017 Conclusion: Telbivudine treatment provided for the HBsAg-positive mothers in second and third trimesters of pregnancy were less likely to develop non-/low-responsive to hepatitis B vaccine in infants since IFN-gamma and IL-10 might have played a vital role in this process. Telbivudine 12-23 interferon gamma Homo sapiens 206-215 28169371-6 2017 DCPAB additionally suppressed transcriptional activity of T-bet on IFN-gamma gene promoter, whereas HPAB had no effect on T-bet activity. dcpab 0-5 interferon gamma Homo sapiens 67-76 28169371-7 2017 IFN-gamma suppressive activity of DCPAB and HPAB was impaired in the absence of T-bet but was retrieved by the restoration of T-bet in T-bet-deficient T cells. dcpab 34-39 interferon gamma Homo sapiens 0-9 28169371-3 2017 In this study, we aimed to discover potent anti-inflammatory compounds that suppress IFN-gamma production and found that the novel benzoxazole derivatives, 2-((3,4-dichlorophenyl) amino) benzo[d]xazol-5-ol (DCPAB) and 2-((3,4-hydroxyphenyl) amino) benzo[d]xazol-5-ol (HPAB), suppressed IFN-gamma production by T cells. Benzoxazoles 131-142 interferon gamma Homo sapiens 286-295 28169371-4 2017 Treatment of CD4+ T cells with DCPAB and HPAB selectively inhibited Th1 cell development, and DCPAB more potently suppressed IFN-gamma than HPAB did. dcpab 94-99 interferon gamma Homo sapiens 125-134 27876461-7 2017 Compared with peripheral blood neutrophils (PBNs), TANs significantly inhibited T cell proliferation and decreased IFN-gamma and TNF-alpha secretion. tans 51-55 interferon gamma Homo sapiens 115-124 27373553-11 2017 Drug-specific CD4+ T cells proliferated and secreted IFN-gamma/granzyme B when stimulated with isoniazid or rifampicin, respectively. Isoniazid 95-104 interferon gamma Homo sapiens 53-62 27373553-11 2017 Drug-specific CD4+ T cells proliferated and secreted IFN-gamma/granzyme B when stimulated with isoniazid or rifampicin, respectively. Rifampin 108-118 interferon gamma Homo sapiens 53-62 26669617-9 2017 Furthermore, the density of TIBs was correlated with an enhanced expression of granzyme B and IFN-gamma, as well as with reduced tumour viability defined by low expression of Ki-67, and an enhanced expression of activated caspase-3 on tumour cells. tibs 28-32 interferon gamma Homo sapiens 94-103 27339255-13 2017 Both in-feed antibiotics and ZnO supplementation decreased the mRNA expression of interferon-gamma (IFN-gamma), but increased the mRNA expression of transforming growth factor-beta (TGF-beta), in the jejunum mucosa of piglets, when compared to those in the control (P < 0.05). Zinc Oxide 29-32 interferon gamma Homo sapiens 82-98 27339255-13 2017 Both in-feed antibiotics and ZnO supplementation decreased the mRNA expression of interferon-gamma (IFN-gamma), but increased the mRNA expression of transforming growth factor-beta (TGF-beta), in the jejunum mucosa of piglets, when compared to those in the control (P < 0.05). Zinc Oxide 29-32 interferon gamma Homo sapiens 100-109 27623929-9 2017 In Caco-2 cells treated with IFNgamma and TNFalpha, OEA (via TRPV1) and PEA (via PPARalpha) prevented or reversed the cytokine-induced increased permeability compared to vehicle (0.1% ethanol). Ethanol 184-191 interferon gamma Homo sapiens 29-37 28102966-9 2017 Treatment with 10 mg/L theophylline + 1 micromol/L prednisolone or 2.5 ng/mL cyclosporine A synergistically upregulated HDAC2 and inhibited IFN-gamma and TNF-alpha production by CD8+ T and NKT-like lymphocytes. Theophylline 23-35 interferon gamma Homo sapiens 140-149 27704206-4 2017 We determined whether teriflunomide affect the production of interferon-gamma, interleukin-2 and tumor-necrosis-factor-alpha in the QuantiFERON-TB in-Tube-assay. teriflunomide 22-35 interferon gamma Homo sapiens 61-77 27704206-6 2017 Teriflunomide resulted in a change in QuantiFERON results from positive to negative in four patients with a marked reduction in interferon-gamma. teriflunomide 0-13 interferon gamma Homo sapiens 128-144 27418662-14 2017 The high level of Thr inclusion (3 g/kg) upregulated mucin-2 mRNA expression (P = 0.034), whereas downregulated the mRNA abundances of interferon-gamma (P = 0.036) and interleukin-1beta (P = 0.031) in the ileum. Threonine 18-21 interferon gamma Homo sapiens 135-151 28031335-6 2017 The phenotype of NKG2C/E+ ThCTL indicates they are highly activated effectors expressing high levels of binding to P-selectin, T-bet, and Blimp-1, and that more of them secrete IFN-gamma and readily degranulate than non-ThCTL. thctl 26-31 interferon gamma Homo sapiens 177-186 27980102-10 2017 In addition, CCL2 nAb enhanced hepatic NK-cell cytotoxicity and IFNgamma production, which is likely to contribute to the inhibition of tumorigenesis. nab 18-21 interferon gamma Homo sapiens 64-72 28102966-9 2017 Treatment with 10 mg/L theophylline + 1 micromol/L prednisolone or 2.5 ng/mL cyclosporine A synergistically upregulated HDAC2 and inhibited IFN-gamma and TNF-alpha production by CD8+ T and NKT-like lymphocytes. Prednisolone 51-63 interferon gamma Homo sapiens 140-149 28102966-9 2017 Treatment with 10 mg/L theophylline + 1 micromol/L prednisolone or 2.5 ng/mL cyclosporine A synergistically upregulated HDAC2 and inhibited IFN-gamma and TNF-alpha production by CD8+ T and NKT-like lymphocytes. Cyclosporine 77-91 interferon gamma Homo sapiens 140-149 27736317-6 2017 OACs in coculture with AMs expressed significantly higher levels of MMP-1, MMP-3, MMP-9, MMP-13, IL-1beta, TNF-alpha, IL-6, IL-8, and IFN-gamma compared to OACs in mono-culture, indicating that proinflammatory macrophages may intensify the abnormal matrix degradation and cytokine secretion already associated with OACs. oacs 0-4 interferon gamma Homo sapiens 134-143 28052005-7 2017 In bortezomib-treated 4T1HA tumor-bearing mice, CD4+T-cells showed increased IL-2 production, CD11c+ dendritic cells showed increased IL-12 and IL-15 production, and HA-specific activated CD8+T-cells showed enhanced expression of IFNgamma, granzyme-B and transcription factor eomesodermin. Bortezomib 3-13 interferon gamma Homo sapiens 230-238 27824294-9 2017 H2O2 determined an increase in endogenous cytokines involved in the response to oxidative stress and GO pathogenesis, namely tumor necrosis factor alpha, interleukin 1 beta, and interferon gamma. Hydrogen Peroxide 0-4 interferon gamma Homo sapiens 178-194 27736317-8 2017 Finally, OACs cultured in the presence of nonactivated macrophages produced lower levels of MMP-9 and proinflammatory cytokines IL-1beta, TNF-alpha, and IFN-gamma compared to OACs in the OAC-AM system, results that are consistent with anti-inflammatory agents temporarily reducing certain OA symptoms. oacs 9-13 interferon gamma Homo sapiens 153-162 27736317-8 2017 Finally, OACs cultured in the presence of nonactivated macrophages produced lower levels of MMP-9 and proinflammatory cytokines IL-1beta, TNF-alpha, and IFN-gamma compared to OACs in the OAC-AM system, results that are consistent with anti-inflammatory agents temporarily reducing certain OA symptoms. SDZ 33-243 9-12 interferon gamma Homo sapiens 153-162 28103263-3 2017 Control of Leishmania infection is mediated by Th1 (IFNgamma-producing) CD4+ T cells, which activate macrophages to produce nitric oxide and kill intracellular parasites. Nitric Oxide 124-136 interferon gamma Homo sapiens 52-60 29296949-8 2017 This observation was highly concordant with clinical samples from allo-SCT recipients receiving CsA-based immune suppression where although the IFNgamma-negative-Th17 subset predominated, IFNgamma+-Th17 cells were also present. Cyclosporine 96-99 interferon gamma Homo sapiens 144-152 29296949-8 2017 This observation was highly concordant with clinical samples from allo-SCT recipients receiving CsA-based immune suppression where although the IFNgamma-negative-Th17 subset predominated, IFNgamma+-Th17 cells were also present. Cyclosporine 96-99 interferon gamma Homo sapiens 188-196 31011016-8 2017 For example, theophylline has been shown to induce a 20 percent fall in pro-inflammatory tumor necrosis factor (TNF) and 180 percent rise in anti-inflammatory interleukin-10 production by peripheral blood monocytes, and a fall of 45 percent in interferon-gamma (IF-gamma) release. Theophylline 13-25 interferon gamma Homo sapiens 244-260 27470968-9 2017 In human GIST cell lines, treatment with imatinib abrogated the IFNgamma-induced upregulation of PD-L1 via STAT1 inhibition. Imatinib Mesylate 41-49 interferon gamma Homo sapiens 64-72 27470968-10 2017 In KitV558Delta/+ mice, imatinib downregulated IFNgamma-related genes and reduced PD-L1 expression on tumor cells. Imatinib Mesylate 24-32 interferon gamma Homo sapiens 47-55 28098169-7 2017 DPSCs treated with IFN-gamma and supplemented with pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor) or SB203580 (a MAPK inhibitor) showed significantly improved potential for odonto/osteogenic differentiation of DPSCs both in vivo and in vitro. pyrrolidine dithiocarbamic acid 51-78 interferon gamma Homo sapiens 19-28 28098169-7 2017 DPSCs treated with IFN-gamma and supplemented with pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor) or SB203580 (a MAPK inhibitor) showed significantly improved potential for odonto/osteogenic differentiation of DPSCs both in vivo and in vitro. pyrrolidine dithiocarbamic acid 80-84 interferon gamma Homo sapiens 19-28 28098169-7 2017 DPSCs treated with IFN-gamma and supplemented with pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor) or SB203580 (a MAPK inhibitor) showed significantly improved potential for odonto/osteogenic differentiation of DPSCs both in vivo and in vitro. SB 203580 113-121 interferon gamma Homo sapiens 19-28 28095433-4 2017 BJ-3105, a 6-alkoxypyridin-3-ol analog, inhibited IFN-gamma and IL-17 production from polyclonal CD4+ T cells and ovalbumin (OVA)-specific CD4+ T cells which were activated by T cell receptor (TCR) engagement. BJ-3105 0-7 interferon gamma Homo sapiens 50-59 28095433-4 2017 BJ-3105, a 6-alkoxypyridin-3-ol analog, inhibited IFN-gamma and IL-17 production from polyclonal CD4+ T cells and ovalbumin (OVA)-specific CD4+ T cells which were activated by T cell receptor (TCR) engagement. 6-alkoxypyridin-3-ol 11-31 interferon gamma Homo sapiens 50-59 28094337-2 2017 Here, we report that glial STAT1 and -3 are distinctively phosphorylated following the interaction of activated lymphocytes and glia, and this effect is significantly inhibited by glatiramer acetate (GA), a disease-modifying drug for MS. GA also reduces the activations of STAT1 and -3 by MS-associated stimuli such as IFNgamma or LPS in primary glia, but not neurons. Glatiramer Acetate 180-198 interferon gamma Homo sapiens 319-327 28094337-2 2017 Here, we report that glial STAT1 and -3 are distinctively phosphorylated following the interaction of activated lymphocytes and glia, and this effect is significantly inhibited by glatiramer acetate (GA), a disease-modifying drug for MS. GA also reduces the activations of STAT1 and -3 by MS-associated stimuli such as IFNgamma or LPS in primary glia, but not neurons. Glatiramer Acetate 200-202 interferon gamma Homo sapiens 319-327 28155064-11 2017 An interesting novel approach is an anti-IFN-gamma antibody (NI-0501), which is currently being tested. ni-0501 61-68 interferon gamma Homo sapiens 41-50 28071969-5 2017 In addition, inhibiting the expression of IFIT2 by shRNA in U937 rescued curcumin-induced apoptosis and exogenous overexpression of IFIT2 by lentiviral transduction or treating with IFNgamma in K562 cells enhanced anti-cancer activity of curcumin. Curcumin 73-81 interferon gamma Homo sapiens 182-190 28071969-5 2017 In addition, inhibiting the expression of IFIT2 by shRNA in U937 rescued curcumin-induced apoptosis and exogenous overexpression of IFIT2 by lentiviral transduction or treating with IFNgamma in K562 cells enhanced anti-cancer activity of curcumin. Curcumin 238-246 interferon gamma Homo sapiens 182-190 27428759-11 2017 Cytokine and receptor expression (CXCR3, interferon gamma and TGF-beta) was higher in large ELS in the epicardial tissue than in other vessel wall layers, suggesting active recruitment and proliferation of T and B lymphocytes. N-[(2S,3S,4R)-3,4-dihydroxy-8-oxo-8-[(4-pentylphenyl)amino]-1-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octan-2-yl]hexacosanamide 92-95 interferon gamma Homo sapiens 41-57 28133458-8 2016 The mechanistic studies demonstrated that two of three co-infected animals had lower levels of M.tb specific IFN-gamma and IL-22 in PBMCs than M.tb mono-infected animals. Terbium 97-99 interferon gamma Homo sapiens 109-118 27702536-4 2017 In this study, AGAF was further demonstrated to induce IFN-gamma expression, increasing the susceptibility to NK-92MI cell-mediated cytotoxicity through the toll-like receptor (TLR)-2, TLR4, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and nuclear factor-kappaB pathways. agaf 15-19 interferon gamma Homo sapiens 55-64 27324793-6 2017 IFN-gamma showed limited effects on TGF-alpha and polyI:C-induced activation of epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase (ERK). Poly I-C 50-57 interferon gamma Homo sapiens 0-9 28151459-11 2017 Both doses of N sativa produced a significant increase in the serum IFN-gamma at 12 weeks vs baseline (P < .05) as well as a significant improvement in the ACT score at 6 and 12 weeks vs baseline (P < .001, < .01). n sativa 14-22 interferon gamma Homo sapiens 68-77 28529951-7 2017 Proinflammation cytokines IFNgamma and TNFalpha in serum increased to or above the normal range in 80.9% of patients at 12 weeks after UCMC transfusion. ucmc 135-139 interferon gamma Homo sapiens 26-34 27923823-6 2017 Bortezomib downregulated IFNgamma-induced IDO expression via inhibition of STAT1 phosphorylation and nuclear translocation, thereby suppressing STAT1-driven IDO transcription in NPC cells. Bortezomib 0-10 interferon gamma Homo sapiens 25-33 27923824-5 2017 Ruxolitinib treatment completely blocked IL2, IL15, and DC-mediated STAT5 phosphorylation, along with the capacity of NK cells to secrete IFNgamma or lyse NK cell-sensitive targets. ruxolitinib 0-11 interferon gamma Homo sapiens 138-146 26631910-5 2017 IFNgamma induced mitochondrial co-localization of RIG-I was concomitant with its ability to regulate ROS generation, oxidative phosphorylation (OXPHOS) and key enzymes involved in glycolysis and pentose phosphate pathway. ros 101-104 interferon gamma Homo sapiens 0-8 26631910-5 2017 IFNgamma induced mitochondrial co-localization of RIG-I was concomitant with its ability to regulate ROS generation, oxidative phosphorylation (OXPHOS) and key enzymes involved in glycolysis and pentose phosphate pathway. Pentosephosphates 195-212 interferon gamma Homo sapiens 0-8 28588641-7 2017 The biological process of response to steroid hormone stimulus and regulation of interferon-gamma production were significantly enriched by DEGs. Steroids 38-53 interferon gamma Homo sapiens 81-97 27833011-6 2017 Ribavirin treatment of uninfected larvae reduces the basal level of IFNgamma, but increases the level of IL-1beta mRNA expression. Ribavirin 0-9 interferon gamma Homo sapiens 68-76 27833011-7 2017 Furthermore, infecting larvae with NNV following ribavirin treatment reduces the expression levels of IFNgamma, IFN-I, Mx, and TNF-alpha genes, while the expression of IL-1beta is increased. Ribavirin 49-58 interferon gamma Homo sapiens 102-110 27814627-5 2017 High IL-10 (p=0.014), IL-23 (p<0.001), IFN-gamma (p<0.001) and MCP-1 (p=0.002) correlated with high 8-OHdG and high IL-23 (p<0.001), INF-gamma (p<0.001), IP-10 (p=0.023) and MCP-1 (p=0.002) correlated with low leukocyte mtDNA. 8-ohdg 106-112 interferon gamma Homo sapiens 42-51 27878235-2 2017 Based on our hypothesis in which continuous exposure to asbestos of immune cells cause reduction of antitumor immunity, the decrease of natural killer cell killing activity with reduction of NKp46 activating receptor expression, inhibition of cytotoxic T cell clonal expansion, reduced CXCR3 chemokine receptor expression and production of interferon-gamma production in CD4+ T cells were reported using cell line models, freshly isolated peripheral blood immune cells from health donors as well as asbestos exposed patients such as pleural plaque and mesothelioma. Asbestos 56-64 interferon gamma Homo sapiens 340-356 28286378-3 2017 Firstly, we characterized the transcription of genes related to iron homeostasis in M1 RAW264.7 macrophages stimulated by IFN-gamma. Iron 64-68 interferon gamma Homo sapiens 122-131 27872213-5 2017 We demonstrate that beta-glucan-stimulated DCs induce CD8 T cell proliferation, activation marker (CD44 and CD69) expression, and production of IFN-gamma, IL-2, and granzyme B. beta-Glucans 20-31 interferon gamma Homo sapiens 144-153 27872213-6 2017 Moreover, we show that type I IFNs support robust CD8 T cell activation (proliferation and IFN-gamma and granzyme B production) by beta-glucan-stimulated DCs in vitro and in vivo due to autocrine effects on the DCs. beta-Glucans 131-142 interferon gamma Homo sapiens 91-100 28286378-6 2017 Iron significantly reduced mRNA levels of IL-6, IL-1beta, TNF-alpha, and iNOS produced by IFN-gamma-polarized M1 macrophages. Iron 0-4 interferon gamma Homo sapiens 90-99 29510394-2 2017 Compared to controls, non-stimulated PBMC from the IBSN group produced a significantly lower level of IL-1ra (by 38%; p < 0.001) and significantly lower levels of TNFalpha, IL-1beta, and IFNgamma (by 36% [p < 0.001], 25% [p = 0.06], and 32% [p < 0.02]) under PBMC stimulation. PBMC 37-41 interferon gamma Homo sapiens 190-198 26924709-2 2017 Several enzymes are able to metabolize tryptophan, but activity of inducible indoleamine 2,3-dioxygenase (IDO-1) plays a major role under pro-inflammatory, interferon-gamma (IFN-gamma) dominated settings. Tryptophan 39-49 interferon gamma Homo sapiens 156-172 26924709-2 2017 Several enzymes are able to metabolize tryptophan, but activity of inducible indoleamine 2,3-dioxygenase (IDO-1) plays a major role under pro-inflammatory, interferon-gamma (IFN-gamma) dominated settings. Tryptophan 39-49 interferon gamma Homo sapiens 174-183 28367199-10 2017 OSAHS group had significantly higher serum levels of IL-4, IL-6, IL-10 and IFN-gamma than those of control group (P<0.05), but their IL-2 and TNF-alpha levels were similar (P>0.05). osahs 0-5 interferon gamma Homo sapiens 75-84 28327819-5 2017 Alternatively, the schistosomiasis-induced increase in prostaglandin E2 levels could have inhibited the production of interferon-gamma, a cytokine fundamental to fungal resistance. Dinoprostone 55-71 interferon gamma Homo sapiens 118-134 29171473-0 2017 [Time course of changes in cytokines (IFN-gamma, IFN-alpha, IL-18, TNF-alpha) in the treatment of moderate influenza A (H1N1) pdm09 (2013-2016) with oseltamivir (Tamiflu) and umifenovir (Arbidol) alone and in combination with Kagocel]. Oseltamivir 149-160 interferon gamma Homo sapiens 38-47 26995730-2 2017 The balance between the production of the two types of metabolites is controlled by key rate-limiting enzymes such as indoleamine-2,3-dioxygenase (IDO-1), and in turn, molecular signals such as interferon-gamma (IFN-gamma), which activate the KP metabolism of tryptophan by this enzyme, as opposed to alternative pathways for serotonin and melatonin production. Tryptophan 260-270 interferon gamma Homo sapiens 194-210 26995730-2 2017 The balance between the production of the two types of metabolites is controlled by key rate-limiting enzymes such as indoleamine-2,3-dioxygenase (IDO-1), and in turn, molecular signals such as interferon-gamma (IFN-gamma), which activate the KP metabolism of tryptophan by this enzyme, as opposed to alternative pathways for serotonin and melatonin production. Tryptophan 260-270 interferon gamma Homo sapiens 212-221 26995730-2 2017 The balance between the production of the two types of metabolites is controlled by key rate-limiting enzymes such as indoleamine-2,3-dioxygenase (IDO-1), and in turn, molecular signals such as interferon-gamma (IFN-gamma), which activate the KP metabolism of tryptophan by this enzyme, as opposed to alternative pathways for serotonin and melatonin production. Serotonin 326-335 interferon gamma Homo sapiens 194-210 26995730-2 2017 The balance between the production of the two types of metabolites is controlled by key rate-limiting enzymes such as indoleamine-2,3-dioxygenase (IDO-1), and in turn, molecular signals such as interferon-gamma (IFN-gamma), which activate the KP metabolism of tryptophan by this enzyme, as opposed to alternative pathways for serotonin and melatonin production. Serotonin 326-335 interferon gamma Homo sapiens 212-221 26995730-2 2017 The balance between the production of the two types of metabolites is controlled by key rate-limiting enzymes such as indoleamine-2,3-dioxygenase (IDO-1), and in turn, molecular signals such as interferon-gamma (IFN-gamma), which activate the KP metabolism of tryptophan by this enzyme, as opposed to alternative pathways for serotonin and melatonin production. Melatonin 340-349 interferon gamma Homo sapiens 194-210 26995730-2 2017 The balance between the production of the two types of metabolites is controlled by key rate-limiting enzymes such as indoleamine-2,3-dioxygenase (IDO-1), and in turn, molecular signals such as interferon-gamma (IFN-gamma), which activate the KP metabolism of tryptophan by this enzyme, as opposed to alternative pathways for serotonin and melatonin production. Melatonin 340-349 interferon gamma Homo sapiens 212-221 28033330-6 2016 The PPD-stimulated IL-2/IFN-gamma ratio after 72h incubation had the diagnostic potential to discriminate between ATB and LTBI, with a sensitivity of 90.8% and a specificity of 97.7%. atb 114-117 interferon gamma Homo sapiens 24-33 27873494-5 2017 Thirteen 9- or 10-amino acid overlapping peptides spanning E749-63, E750-59 (AHYNIVTFCC), and E752-61 (YNIVTFCCKC) induced significantly higher IFN-gamma production and cytotoxic effects against SNU1299 cells than the other peptides and negative controls, and the cytotoxicity of E750-59- and E752-61-sensitized PBMCs was induced via the cytolytic effect of CD8+ CTLs. 9- or 10-amino acid 9-28 interferon gamma Homo sapiens 144-153 28680742-7 2017 Since MSA treatment enhanced MHC class I surface expression also on different human tumors cell lines, MSA might affect the malignant phenotype of various tumor cells by restoring MHC class I APM component expression due to an altered redox status and by partially mimicking IFN-gamma signaling thereby providing a novel mechanism for the chemotherapeutic potential of methylselenol generating Se compounds. methylselenic acid 6-9 interferon gamma Homo sapiens 275-284 27817193-7 2016 Up-regulation ofmiR-155 expression by IFN-gamma in bile duct cells led to the activation of signal transducers and activatorsof transcription 1 (Stat1) and inflammatory cytokines through the Janus kinase (Jak)/Stat pathway, whereas targeted inhibition of miR-155 expression by anti-miRNA oligonucleotides significantly decreased the mRNA or protein expression levels of these inflammatorycytokines and Stat1. Oligonucleotides 288-304 interferon gamma Homo sapiens 38-47 28170190-6 2017 Delivery of IFN-gamma via heparin-microparticles within MSC aggregates induced sustained IDO expression during 1 week of culture, whereas IDO expression by IFN-gamma-pretreated MSC spheroids rapidly decreased during 2 days. Heparin 26-33 interferon gamma Homo sapiens 12-21 28680742-7 2017 Since MSA treatment enhanced MHC class I surface expression also on different human tumors cell lines, MSA might affect the malignant phenotype of various tumor cells by restoring MHC class I APM component expression due to an altered redox status and by partially mimicking IFN-gamma signaling thereby providing a novel mechanism for the chemotherapeutic potential of methylselenol generating Se compounds. methylselenic acid 103-106 interferon gamma Homo sapiens 275-284 28018290-4 2016 Control and CSS-exposed F1 dams were administered IN saline, AVP, or OXT during lactation and the F2 juvenile female offspring were assessed for basal plasma IFNgamma and perseverative, anxiety, and social behavior. thiocysteine 12-15 interferon gamma Homo sapiens 158-166 27998463-4 2016 The expression levels of PD-LI and IFN-gamma in tumor cells and T lymphocytes treated with erlotinib in co-culture system were analyzed by flow cytometry and ELISA, respectively. Erlotinib Hydrochloride 91-100 interferon gamma Homo sapiens 35-44 27998463-9 2016 Before and after treatment with erlotinib, the secretion levels of IFN-gamma were (856.0+-70.3)pg/ml and (1 697.3+-161.0)pg/ml, respectively, showing a significant difference (P<0.001). Erlotinib Hydrochloride 32-41 interferon gamma Homo sapiens 67-76 27964715-13 2016 In the same way, PA reduced IL6, IFN-gamma, TNF-alpha and IL17A production in both concentration and IL2 only at 50 muM (in the presence of ConA). palmitoleic acid 17-19 interferon gamma Homo sapiens 33-42 27479047-0 2016 Amperometric IFN-gamma immunosensors with commercially fabricated PCB sensing electrodes. pcb 66-69 interferon gamma Homo sapiens 13-22 27479047-4 2016 In this paper we focus on transferring a complete IFN-gamma enzyme-linked immune-sorbent assay (ELISA) onto a commercial PCB electrochemical biosensing platform, We adapted a commercially available ELISA to detect the enzyme product TMB/H2O2 using amperometry, successfully reproducing the colorimetry-obtained ELISA standard curve. 3,3',5,5'-tetramethylbenzidine 233-236 interferon gamma Homo sapiens 50-59 27479047-4 2016 In this paper we focus on transferring a complete IFN-gamma enzyme-linked immune-sorbent assay (ELISA) onto a commercial PCB electrochemical biosensing platform, We adapted a commercially available ELISA to detect the enzyme product TMB/H2O2 using amperometry, successfully reproducing the colorimetry-obtained ELISA standard curve. Hydrogen Peroxide 237-241 interferon gamma Homo sapiens 50-59 27821549-6 2016 Furthermore, when expressed in macrophages, the mycolactone-resistant mutant restored IFN-gamma receptor-mediated antimicrobial responses. mycolactone 48-59 interferon gamma Homo sapiens 86-95 27539106-10 2016 Pretreatment with a guanylate cyclase inhibitor, 6-anilino-5,8-quinolinedione (LY83583), led to a further increase in IFN-gamma-induced HUVECs hyperpermeability. 6-anilino-5,8-quinolinedione 49-77 interferon gamma Homo sapiens 118-127 27539106-0 2016 Nitric oxide participates in IFN-gamma-induced HUVECs hyperpermeability. Nitric Oxide 0-12 interferon gamma Homo sapiens 29-38 27539106-3 2016 In this study, we assessed the effect of interferon-gamma (IFN-gamma), a pro-inflammatory cytokine, on NO and cGMP levels and examined the mechanisms by which NO and cGMP regulate the IFN-gamma-mediated HUVECs hyperpermeability. Cyclic GMP 110-114 interferon gamma Homo sapiens 59-68 27973447-5 2016 We found that 1,25(OH)2D3 significantly reduced pro-inflammatory cytokines TNF-alpha, IFN-gamma, and IL-1beta as well as the chemokine IL-8 for both ligands (three- to 53-fold), while anti-inflammatory IL-10 was increased (two-fold, p = 0.016) in HK19F-stimulated monocytes. Calcitriol 14-25 interferon gamma Homo sapiens 86-95 27539106-3 2016 In this study, we assessed the effect of interferon-gamma (IFN-gamma), a pro-inflammatory cytokine, on NO and cGMP levels and examined the mechanisms by which NO and cGMP regulate the IFN-gamma-mediated HUVECs hyperpermeability. Cyclic GMP 166-170 interferon gamma Homo sapiens 184-193 27539106-5 2016 Here, we found that IFN-gamma significantly attenuated basal NO concentration and the increased NO levels supplied by a NO donor, sodium nitroprusside (SNP). Nitroprusside 130-150 interferon gamma Homo sapiens 20-29 27539106-6 2016 Besides, application of IFN-gamma also significantly attenuated both the basal cGMP concentration and the increased cGMP production donated by a cell permeable cGMP analogue, 8-bromo-cyclic GMP (8-Br-cGMP). Cyclic GMP 79-83 interferon gamma Homo sapiens 24-33 27539106-6 2016 Besides, application of IFN-gamma also significantly attenuated both the basal cGMP concentration and the increased cGMP production donated by a cell permeable cGMP analogue, 8-bromo-cyclic GMP (8-Br-cGMP). Cyclic GMP 116-120 interferon gamma Homo sapiens 24-33 27539106-6 2016 Besides, application of IFN-gamma also significantly attenuated both the basal cGMP concentration and the increased cGMP production donated by a cell permeable cGMP analogue, 8-bromo-cyclic GMP (8-Br-cGMP). Cyclic GMP 116-120 interferon gamma Homo sapiens 24-33 27539106-6 2016 Besides, application of IFN-gamma also significantly attenuated both the basal cGMP concentration and the increased cGMP production donated by a cell permeable cGMP analogue, 8-bromo-cyclic GMP (8-Br-cGMP). 8-bromocyclic GMP 175-193 interferon gamma Homo sapiens 24-33 27539106-6 2016 Besides, application of IFN-gamma also significantly attenuated both the basal cGMP concentration and the increased cGMP production donated by a cell permeable cGMP analogue, 8-bromo-cyclic GMP (8-Br-cGMP). 8-bromocyclic GMP 195-204 interferon gamma Homo sapiens 24-33 27539106-9 2016 L-NAME pretreatment followed by SNP or SNP pretreatment partially reduced IFN-gamma-induced HUVECs hyperpermeability. NG-Nitroarginine Methyl Ester 0-6 interferon gamma Homo sapiens 74-83 27539106-10 2016 Pretreatment with a guanylate cyclase inhibitor, 6-anilino-5,8-quinolinedione (LY83583), led to a further increase in IFN-gamma-induced HUVECs hyperpermeability. 6-anilino-5,8-quinolinedione 79-86 interferon gamma Homo sapiens 118-127 27973447-6 2016 Levels of HK19F-specific IFN-gamma were significantly higher (11.7-fold, p = 0.038) in vitamin D-insufficient adults (<50 nmol/L) compared to sufficient adults (>50 nmol/L). Vitamin D 87-96 interferon gamma Homo sapiens 25-34 27793801-6 2016 Interestingly, Runx3 can be synergistically induced by IFNgamma with a synthetic analog of viral dsRNA polyinosinic-polycytidylic acid [poly(I:C)] or tumor necrosis factor-alpha (TNFalpha) through both JAK-STAT1 and NF-kappaB pathways. Poly I-C 103-134 interferon gamma Homo sapiens 55-63 27980422-0 2016 Progesterone Alters Kynurenine Pathway Activation in IFN-gamma-Activated Macrophages - Relevance for Neuroinflammatory Diseases. Progesterone 0-12 interferon gamma Homo sapiens 53-62 27980422-0 2016 Progesterone Alters Kynurenine Pathway Activation in IFN-gamma-Activated Macrophages - Relevance for Neuroinflammatory Diseases. Kynurenine 20-30 interferon gamma Homo sapiens 53-62 27980422-4 2016 We found that progesterone attenuates interferon-gamma-induced KP activity, decreases the levels of the excitotoxin quinolinic acid, and increases the neuroprotective kynurenic acid levels. Kynurenic Acid 167-181 interferon gamma Homo sapiens 38-54 27492707-5 2016 In addition, thalidomide and its analogs inhibit release of tumor necrosis factor-alpha and increase interleukin-2 (IL-2) and interferon-gamma release from T cells. Thalidomide 13-24 interferon gamma Homo sapiens 126-142 28000585-3 2016 This study determined the relationship between the IFN-gamma +874 A/T promoter polymorphism and the performance of the QuantiFERON -TB Gold In-Tube (QFT-GIT) test in an ethnically diverse Canadian population. tb gold 132-139 interferon gamma Homo sapiens 51-60 27502245-9 2016 NO production and GAG release by the cartilage was increased when cultured with M(IFNgamma+TNFalpha) MCM. Glycosaminoglycans 18-21 interferon gamma Homo sapiens 82-90 27435343-4 2016 Furthermore, the use of Au nanoparticles also generated enhanced immunogenicity of CpG and VLPs on both humoral and cellular immune pathways, as followed from increased expressions of total HBc-specific antibody titer, CD4(+) T cells, CD8(+) T cells, cytokine interleukin-4, and interferon-gamma. Gold 24-26 interferon gamma Homo sapiens 279-295 27665290-9 2016 We found that indomethacine, an inhibitor of cyclooxygenase-2 (Cox-2) activity, completely abrogated the inhibition of IL-10 production in cultures containing MSCs and IFN-gamma, but had no effect on the suppression in cell cultures containing MSCs and IL-4. Indomethacin 14-27 interferon gamma Homo sapiens 168-177 27995420-5 2016 In our studies, lactic acid in tumor microenvironments inhibited IFNgamma and IL4 productions from NKT cells, and more profound influence on IFNgamma was observed. Lactic Acid 16-27 interferon gamma Homo sapiens 65-73 27941164-0 2016 Single nucleotide polymorphisms of IFNgamma (+874 A/T) and IFNgammaR1 (-56 C/T) in Iranian patients with TB. Terbium 105-107 interferon gamma Homo sapiens 35-43 27995420-5 2016 In our studies, lactic acid in tumor microenvironments inhibited IFNgamma and IL4 productions from NKT cells, and more profound influence on IFNgamma was observed. Lactic Acid 16-27 interferon gamma Homo sapiens 141-149 28024468-4 2016 RESULTS: Both IDO and TLR9 mRNA were expressed in HL-60 and K562 cells; IFN-gamma increased the expression and activity of IDO in a concentration-dependent manner; Talpha1 decreased the expression and activity of IDO in a concentration-dependent manner; the up-regulation of IFN-gamma on IDO induced expression and activity had been weakened by Talpha1(P<0.01); Chloroquine had no effect on the expression of IDO. Chloroquine 365-376 interferon gamma Homo sapiens 72-81 27865390-7 2016 Vaccine-induced multifunctional CD4 T-cells producing IFN-gamma and TNF-alpha were associated with reduced disease pathology following subsequent M.tb challenge; however, high frequencies of this population following M.tb infection correlated with increased pathology. Terbium 148-150 interferon gamma Homo sapiens 54-63 28024504-6 2016 The plasma IFN-gamma level detected in ITP group before and after treatment was not significantly different from level in control group (P>0.05), while the IL-4 level in ITP group before treatment was significantly lower than that in control grup (t=2.107, P<0.05), but the IL-4 level in ITP group after treatment was significantly higher than that in control group (t=2.107, P<0.05). Inosine Triphosphate 39-42 interferon gamma Homo sapiens 11-20 28024504-7 2016 The plasma IFN-gamma/IL-4 ratio in ITP group before treatment was significantly higher than that in control group (t=5.436, P<0.01), but it obviously decreased and was slightly lower than that in control group after treatment. Inosine Triphosphate 35-38 interferon gamma Homo sapiens 11-20 27941164-3 2016 METHODS: We investigated the single nucleotide polymorphisms (SNPs) in genes of IFNgamma (+874 A/T) and IFNgammaR1 (-56 C/T) and serum level of IFNgamma and their influence on TB in patients; 300 patients with TB and 300 healthy controls were enrolled in this study. Terbium 176-178 interferon gamma Homo sapiens 80-88 27941164-3 2016 METHODS: We investigated the single nucleotide polymorphisms (SNPs) in genes of IFNgamma (+874 A/T) and IFNgammaR1 (-56 C/T) and serum level of IFNgamma and their influence on TB in patients; 300 patients with TB and 300 healthy controls were enrolled in this study. Terbium 176-178 interferon gamma Homo sapiens 104-112 27941164-3 2016 METHODS: We investigated the single nucleotide polymorphisms (SNPs) in genes of IFNgamma (+874 A/T) and IFNgammaR1 (-56 C/T) and serum level of IFNgamma and their influence on TB in patients; 300 patients with TB and 300 healthy controls were enrolled in this study. Terbium 210-212 interferon gamma Homo sapiens 80-88 27941164-3 2016 METHODS: We investigated the single nucleotide polymorphisms (SNPs) in genes of IFNgamma (+874 A/T) and IFNgammaR1 (-56 C/T) and serum level of IFNgamma and their influence on TB in patients; 300 patients with TB and 300 healthy controls were enrolled in this study. Terbium 210-212 interferon gamma Homo sapiens 104-112 27941164-7 2016 The serum level of IFNgamma was significantly higher in patients with TB than in controls, but there was no significant difference between serum level of IFNgamma and the studied genotypes (p>0.05). Terbium 70-72 interferon gamma Homo sapiens 19-27 27941164-8 2016 CONCLUSIONS: The cause of active TB in the patients seems to be due to the lack of effective IFNgamma function or the lack of effective signaling connection between IFNgamma and its receptor in presence of -56 C/T polymorphism in promoter region of IFNgammaR1 gene. Terbium 33-35 interferon gamma Homo sapiens 93-101 27459735-12 2016 When T cells were co-cultured with TAMs, expression levels of Tim-3, PD-1 and CTLA-4 were significantly higher than controls, whereas levels of IFN-gamma and Granzyme B were significantly decreased, in a dose-dependent manner (p < 0.05). tams 35-39 interferon gamma Homo sapiens 144-153 27966327-0 2016 Effect of methylprednisolone injection on interleukin-4 and interferon-gamma expression following hepatitis B vaccination in mice. Methylprednisolone 10-28 interferon gamma Homo sapiens 60-76 27966327-4 2016 Therefore, we decided to find out if methylprednisolone injection decreases interleukin-4 and interferon-gamma expression following hepatitis B vaccination in mice. Methylprednisolone 37-55 interferon gamma Homo sapiens 94-110 27833154-6 2016 We found the levels of cytokines, including nterleukin (IL)-6, IL-10, interferon gamma (IFN-gamma) in RMPP group were significantly higher than those in GMPP group (P < 0.01). rmpp 102-106 interferon gamma Homo sapiens 70-97 27799536-7 2016 Anti-PD-1 plus intratumoral SD-101 promoted infiltration of activated, proliferating CD8+ T cells and led to a synergistic increase in total and tumor antigen-specific CD8+ T cells expressing both IFN-gamma and TNF-alpha. sd-101 28-34 interferon gamma Homo sapiens 197-206 27841267-6 2016 A. muciniphila is also linked to IFNgamma-regulated gene expression in the intestine and glucose parameters in humans, suggesting that this trialogue between IFNgamma, A. muciniphila and glucose tolerance might be an evolutionally conserved mechanism regulating metabolic health in mice and humans. Glucose 89-96 interferon gamma Homo sapiens 158-166 27833154-7 2016 In ROC curve analysis, IL-10 and IFN-gamma were useful for differentiating patients with RMPP from those with GMPP. rmpp 89-93 interferon gamma Homo sapiens 33-42 27833154-7 2016 In ROC curve analysis, IL-10 and IFN-gamma were useful for differentiating patients with RMPP from those with GMPP. gmpp 110-114 interferon gamma Homo sapiens 33-42 27833154-8 2016 Logistic regression analysis showed that the IL-10 >= 3.65 pg/ml and IFN-gamma >= 29.05 pg/ml were significant predictors regarding to RMPP. rmpp 141-145 interferon gamma Homo sapiens 72-81 27833154-10 2016 CONCLUSIONS: IL-10 and IFN-gamma could be used as the good predictors of RMPP in school-aged children. rmpp 73-77 interferon gamma Homo sapiens 23-32 27992360-8 2016 CKD serum/homocysteine/CD40L/increased TNF-alpha/IL-6/IFN-gamma-induced CD40/CD40 intermediate monocyte in peripheral blood monocyte. Homocysteine 10-22 interferon gamma Homo sapiens 54-63 27641098-5 2016 Pathophysiological concentrations of lactic acid prevented upregulation of nuclear factor of activated T cells (NFAT) in T and NK cells, resulting in diminished IFN-gamma production. Lactic Acid 37-48 interferon gamma Homo sapiens 161-170 27829019-4 2016 Results showed that Treg/HIV+ inhibited significantly the IFN-gamma expression of autologous CD8+ T cells stimulated with recall CMV/EBV/Flu (CEF) antigens, but did not inhibit HIV-Gag-specific CD8+ T cells. cef 142-145 interferon gamma Homo sapiens 58-67 27877174-6 2016 The analysis of cytokine production revealed that CD4+CD25- T cells with 5-Aza treatment produced comparable levels of interferon (IFN)-gamma and transforming growth factor (TGF)-beta, but less IL-10 and more IL-2, when compared to cells without 5-Aza treatment. Azacitidine 73-78 interferon gamma Homo sapiens 119-141 28197370-9 2017 Immunofluorescence staining of CAS samples revealed that PD-L1-positive cells were adjacent to PD-1-positive cells and/or tumor stroma with high IFNgamma expression. cas 31-34 interferon gamma Homo sapiens 145-153 27814509-4 2016 Validation of two predicted host-microbial interactions reveal that TNFalpha and IFNgamma production are associated with specific microbial metabolic pathways: palmitoleic acid metabolism and tryptophan degradation to tryptophol. palmitoleic acid 160-176 interferon gamma Homo sapiens 81-89 27814509-4 2016 Validation of two predicted host-microbial interactions reveal that TNFalpha and IFNgamma production are associated with specific microbial metabolic pathways: palmitoleic acid metabolism and tryptophan degradation to tryptophol. Tryptophan 192-202 interferon gamma Homo sapiens 81-89 27106261-7 2016 RESULTS: The numbers of IFN-gamma-releasing cells in allopurinol-allergic subjects were significantly higher than in control subjects when stimulating PBMCs with oxypurinol 100 mug mL-1 , especially when adding anti-PD-L1 supplementation. Allopurinol 53-64 interferon gamma Homo sapiens 24-33 27814509-4 2016 Validation of two predicted host-microbial interactions reveal that TNFalpha and IFNgamma production are associated with specific microbial metabolic pathways: palmitoleic acid metabolism and tryptophan degradation to tryptophol. tryptophol 218-228 interferon gamma Homo sapiens 81-89 27582398-9 2016 However, other abnormalities are also reported in this type of asthma as a resistance to anti-inflammatory activity of prostaglandin E2 or a robust eosinophil interferon-gamma response resulting in cysteinyl leukotrienes production. cysteinyl-leukotriene 198-220 interferon gamma Homo sapiens 159-175 27106261-8 2016 According to the receiver operating characteristic curve results, the optimal discriminatory power of IFN-gamma ELISpot in confirming diagnosis of allopurinol-induced SCARs can be obtained using 16 spot-forming cells per 106 PBMCs as a cut-off value upon oxypurinol/anti-PD-L1 stimulation (79 2% sensitivity and 95 2% specificity). Oxypurinol 255-265 interferon gamma Homo sapiens 102-111 27845745-7 2016 Greatest inhibition by procyanidin A2 was seen with a 2 h exposure prior to IL-4, whereas IFNgamma inhibition was greatest at 24 h. Concomitant incubation of procyanidin A2 and IFNgamma did not extend the inhibitory efficacy of procyanidin A2. Aligeron 35-37 interferon gamma Homo sapiens 177-185 27106261-7 2016 RESULTS: The numbers of IFN-gamma-releasing cells in allopurinol-allergic subjects were significantly higher than in control subjects when stimulating PBMCs with oxypurinol 100 mug mL-1 , especially when adding anti-PD-L1 supplementation. Oxypurinol 162-172 interferon gamma Homo sapiens 24-33 27106261-9 2016 CONCLUSIONS: The measurement of oxypurinol/anti-PD-L1-inducing IFN-gamma-releasing cells yields a high diagnostic value in distinguishing between allopurinol-allergic and control subjects. Oxypurinol 32-42 interferon gamma Homo sapiens 63-72 27106261-9 2016 CONCLUSIONS: The measurement of oxypurinol/anti-PD-L1-inducing IFN-gamma-releasing cells yields a high diagnostic value in distinguishing between allopurinol-allergic and control subjects. Allopurinol 146-157 interferon gamma Homo sapiens 63-72 27106261-8 2016 According to the receiver operating characteristic curve results, the optimal discriminatory power of IFN-gamma ELISpot in confirming diagnosis of allopurinol-induced SCARs can be obtained using 16 spot-forming cells per 106 PBMCs as a cut-off value upon oxypurinol/anti-PD-L1 stimulation (79 2% sensitivity and 95 2% specificity). Allopurinol 147-158 interferon gamma Homo sapiens 102-111 27390280-2 2016 We evaluated for the first time the performance of a new type of interferon-gamma release assay, QuantiFERON-TB Plus (QFT-Plus), which includes an additional antigen tube (TB2), stimulating both CD4+ and CD8+ T-cells in contacts of TB patients.Contacts were screened for latent TB infection by tuberculin skin test, QFT-Plus and QuantiFERON-TB Gold in Tube (QFT-GIT).In 119 TB contacts, the overall agreement between QFT-Plus and QFT-GIT was high, with a Cohen"s kappa of 0.8. tb gold 341-348 interferon gamma Homo sapiens 65-81 27717877-7 2016 Treatment with 1,25(OH)2D3 resulted in significant up-regulation of IL-4, IL-10, arginase activity, and p-STAT6 and, conversely, down-regulation of IFN-gamma, IL-17 and NO production levels, as well as p-STAT4. ,25(oh)2d3 16-26 interferon gamma Homo sapiens 148-157 27664570-4 2016 In addition, AZM increased endocytosis and/or expression of Toll-like receptor (TLR)2, TLR4, and TLR9 in DCs and suppressed anti-CD3/CD28-induced CD4+ T cell proliferation and interferon-gamma production, an effect that was synergistic with dexamethasone. Azithromycin 13-16 interferon gamma Homo sapiens 176-192 27221136-1 2016 BACKGROUND: Neopterin levels and kynurenine/tryptophan ratios (KTRs) increase with IFN-gamma stimulation, indicating TH1 immunity, and thus might be inversely associated with asthma. Neopterin 12-21 interferon gamma Homo sapiens 83-92 27694494-6 2016 AEA-treated keratinocytes showed reduced an induction of IFN-gamma-producing TH1 and IL-17-producing TH17 cells, and these effects were reverted by pharmacological inhibition of CB1 Further analyses identified mammalian target of rapamycin as a proinflammatory signaling pathway regulated by CB1, able to promote either IL-12 and IL-23 release from keratinocytes or TH1 and TH17 polarization. anandamide 0-3 interferon gamma Homo sapiens 57-66 27353438-7 2016 U0126 also inhibited IFN-gamma secretion and Fas expression close to control levels. U 0126 0-5 interferon gamma Homo sapiens 21-30 27562088-5 2016 In vivo, 6-shogaol inhibited the development of DNCB-induced AD-like skin lesions and scratching behavior, and showed significant reduction in Th2/1-mediated inflammatory cytokines, IgE, TNF-alpha, IFN-gamma, thymus and activation-regulated chemokine, IL-1, 4, 12, and 13, cyclooxygenase-2, and nitric oxide synthase levels. shogaol 9-18 interferon gamma Homo sapiens 198-207 27602793-9 2016 However, a substantial reduction in the frequency of CD4+ and CD8+ memory T-cells able to produce interferon (IFN)-gamma following activation were noted in the blood of TCV-treated patients. Trichloroethylene 169-172 interferon gamma Homo sapiens 98-120 27529445-6 2016 The first model indicated that neurons due to injury with pro-inflammatory agents (IFN-gamma) release soluble neurotoxic factors, including COX-2, reactive oxygen species, and calpain, thus activating microglia, which in turn released neurotoxic factors as well. Oxygen 156-162 interferon gamma Homo sapiens 83-92 27600191-4 2016 GPR14-siRNA transfection subsequent with GPR14 inhibition reduced DSS-induced interferon-gamma (IFN)-gamma production in Caco-2 cells. Dextran Sulfate 66-69 interferon gamma Homo sapiens 78-106 27221136-1 2016 BACKGROUND: Neopterin levels and kynurenine/tryptophan ratios (KTRs) increase with IFN-gamma stimulation, indicating TH1 immunity, and thus might be inversely associated with asthma. Kynurenine 33-43 interferon gamma Homo sapiens 83-92 27221136-1 2016 BACKGROUND: Neopterin levels and kynurenine/tryptophan ratios (KTRs) increase with IFN-gamma stimulation, indicating TH1 immunity, and thus might be inversely associated with asthma. Tryptophan 44-54 interferon gamma Homo sapiens 83-92 27752051-6 2016 Interestingly, T cells from fingolimod-treated patients exhibited interferon-gamma biased production, and more myelin basic protein-reactive cells was noted in CD56+ than in CD56- T cells. Fingolimod Hydrochloride 28-38 interferon gamma Homo sapiens 66-82 27637085-0 2016 Dual oxidase 2 and pancreatic adenocarcinoma: IFN-gamma-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1alpha and VEGF-A. Hydrogen Peroxide 106-110 interferon gamma Homo sapiens 46-55 27637085-2 2016 We found previously that exposure of pancreatic ductal adenocarcinoma cells to the pro-inflammatory cytokine IFN-gamma increased DUOX2 expression (but not other NADPH oxidases) leading to long-lived H2O2 production. Hydrogen Peroxide 199-203 interferon gamma Homo sapiens 109-118 27637085-3 2016 To elucidate the pathophysiology of DUOX2-mediated H2O2 formation in the pancreas further, we demonstrate here that IFN-gamma-treated BxPC-3 and CFPAC-1 pancreatic cancer cells (known to increase DUOX2 expression) produce significant levels of intracellular oxidants and extracellular H2O2 which correlate with concomitant up-regulation of VEGF-A and HIF-1alpha transcription. Hydrogen Peroxide 51-55 interferon gamma Homo sapiens 116-125 27637085-3 2016 To elucidate the pathophysiology of DUOX2-mediated H2O2 formation in the pancreas further, we demonstrate here that IFN-gamma-treated BxPC-3 and CFPAC-1 pancreatic cancer cells (known to increase DUOX2 expression) produce significant levels of intracellular oxidants and extracellular H2O2 which correlate with concomitant up-regulation of VEGF-A and HIF-1alpha transcription. Hydrogen Peroxide 285-289 interferon gamma Homo sapiens 116-125 27637085-5 2016 DUOX2 knockdown with short interfering RNA significantly decreased IFN-gamma-induced VEGF-A or HIF-1alpha up-regulation, as did treatment of pancreatic cancer cells with the NADPH oxidase inhibitor diphenylene iodonium, the multifunctional reduced thiol N-acetylcysteine, and the polyethylene glycol-modified form of the hydrogen peroxide detoxifying enzyme catalase. diphenyleneiodonium 198-218 interferon gamma Homo sapiens 67-76 27637085-5 2016 DUOX2 knockdown with short interfering RNA significantly decreased IFN-gamma-induced VEGF-A or HIF-1alpha up-regulation, as did treatment of pancreatic cancer cells with the NADPH oxidase inhibitor diphenylene iodonium, the multifunctional reduced thiol N-acetylcysteine, and the polyethylene glycol-modified form of the hydrogen peroxide detoxifying enzyme catalase. Sulfhydryl Compounds 248-253 interferon gamma Homo sapiens 67-76 27637085-5 2016 DUOX2 knockdown with short interfering RNA significantly decreased IFN-gamma-induced VEGF-A or HIF-1alpha up-regulation, as did treatment of pancreatic cancer cells with the NADPH oxidase inhibitor diphenylene iodonium, the multifunctional reduced thiol N-acetylcysteine, and the polyethylene glycol-modified form of the hydrogen peroxide detoxifying enzyme catalase. Acetylcysteine 254-270 interferon gamma Homo sapiens 67-76 27637085-5 2016 DUOX2 knockdown with short interfering RNA significantly decreased IFN-gamma-induced VEGF-A or HIF-1alpha up-regulation, as did treatment of pancreatic cancer cells with the NADPH oxidase inhibitor diphenylene iodonium, the multifunctional reduced thiol N-acetylcysteine, and the polyethylene glycol-modified form of the hydrogen peroxide detoxifying enzyme catalase. Polyethylene Glycols 280-299 interferon gamma Homo sapiens 67-76 27637085-5 2016 DUOX2 knockdown with short interfering RNA significantly decreased IFN-gamma-induced VEGF-A or HIF-1alpha up-regulation, as did treatment of pancreatic cancer cells with the NADPH oxidase inhibitor diphenylene iodonium, the multifunctional reduced thiol N-acetylcysteine, and the polyethylene glycol-modified form of the hydrogen peroxide detoxifying enzyme catalase. Hydrogen 321-329 interferon gamma Homo sapiens 67-76 27857897-0 2016 Interleukin-4 and interferon-gamma are possible allergic markers in pediatric patients with beta-lactam hypersensitivity. beta-Lactams 92-103 interferon gamma Homo sapiens 18-34 27644876-5 2016 Estrogen suppresses IFNgamma, which is elevated by fluoride, playing a pivotal role in triggering bone loss in estrogen-deficient conditions. Fluorides 51-59 interferon gamma Homo sapiens 20-28 27644876-12 2016 Thus, stimulation of IFNgamma production is a pivotal ""upstream"" mechanism by which fluoride promotes bone loss. Fluorides 86-94 interferon gamma Homo sapiens 21-29 27523388-6 2016 The antigen-specific release of each cytokine, IFN-gamma, IP-10, and MCP-1, was significantly higher in the TB groups than in either the non-tuberculous pulmonary disease group (p < 0.001) or the healthy control group (p < 0.001). Terbium 108-110 interferon gamma Homo sapiens 47-56 27611715-3 2016 Therefore, in this study the effect of different concentrations of NaB on the percentage and mRNA levels of IL-4 and interferon gamma (IFN-gamma)-producing peripheral blood mononuclear cells (PBMCs) of 20 Relapsing-remitting multiple sclerosis (RR-MS) patients and eight healthy controls was evaluated in the presence of mitogen (phytohemagglutinin, PHA) or specific antigen (myelin basic protein, MBP). nab 67-70 interferon gamma Homo sapiens 117-144 27611715-6 2016 Moreover, in the patient"s group the percentage of CD4(+)IFN-gamma(+) cells was decreased significantly when the PBMCs were stimulated by PHA and NaB (p < 0.004) or by MBP and 1000 microg/ml of NaB (p < 0.03). nab 146-149 interferon gamma Homo sapiens 57-66 27611715-6 2016 Moreover, in the patient"s group the percentage of CD4(+)IFN-gamma(+) cells was decreased significantly when the PBMCs were stimulated by PHA and NaB (p < 0.004) or by MBP and 1000 microg/ml of NaB (p < 0.03). nab 197-200 interferon gamma Homo sapiens 57-66 27611715-7 2016 The effect of NaB on IL-4 and IFN-gamma production was also documented at the mRNA levels. nab 14-17 interferon gamma Homo sapiens 30-39 28248030-7 2016 Pathogenic therapy of sexually transmitted infections in combination with interferon-gamma (Ingaron) contributes to the eradication of bacterial pathogens, prevention of viral STI recurrence and elimination of high oncogenic risk types of HPV. ingaron 92-99 interferon gamma Homo sapiens 74-90 27343379-11 2016 Simvastatin induced IFNgamma in Th1/Tc1-cells in PBMCs of all cohorts except asthmatics. Simvastatin 0-11 interferon gamma Homo sapiens 20-28 27343379-14 2016 Asthma pathogenesis prevents simvastatin-induced IFNgamma up-regulation. Simvastatin 29-40 interferon gamma Homo sapiens 49-57 27461134-6 2016 Consistently, the functional studies demonstrated that MAIT cells from pSS showed a lower level of activation with reduced expression of CD69 and CD154 (CD40L), and a lower production of TNF and IFN-gamma. pss 71-74 interferon gamma Homo sapiens 195-204 27517518-6 2016 Furthermore, gene expressions of interleukin-12 receptor beta2 and IFN-gamma in Peyer"s patches were augmented on day 4 by 06CC2 administration. 06cc2 123-128 interferon gamma Homo sapiens 67-76 27671170-8 2016 Importantly, decitabine treatment further enhanced T cell-mediated cytotoxicity and release of IFN- gamma against target tumor cells which is induced by IR. Decitabine 13-23 interferon gamma Homo sapiens 95-105 29933531-1 2016 OBJECTIVE: To investigate the effect of Sanhuangyilong decoction plus methotrexate (MTX) on Interferongamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in the serum and synovial fluid of rheumatoid arthritis (RA) patients with damp-heat-obstruction symptom pattern, Sanhuangyilong decoctionand the role of TNF-alpha and IFN-gamma in the development of RA. Methotrexate 70-82 interferon gamma Homo sapiens 92-118 29933531-1 2016 OBJECTIVE: To investigate the effect of Sanhuangyilong decoction plus methotrexate (MTX) on Interferongamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in the serum and synovial fluid of rheumatoid arthritis (RA) patients with damp-heat-obstruction symptom pattern, Sanhuangyilong decoctionand the role of TNF-alpha and IFN-gamma in the development of RA. Methotrexate 84-87 interferon gamma Homo sapiens 92-118 27423494-2 2016 We have previously demonstrated the capacity of IFN-gamma to drive cysteinyl leukotriene expression and response. cysteinyl-leukotriene 67-88 interferon gamma Homo sapiens 48-57 27423494-13 2016 IFN-gamma-matured eosinophil progenitors showed enhanced hPGDS expression and increased levels of PGD2 release at baseline and after aspirin stimulation. Prostaglandin D2 98-102 interferon gamma Homo sapiens 0-9 27423494-13 2016 IFN-gamma-matured eosinophil progenitors showed enhanced hPGDS expression and increased levels of PGD2 release at baseline and after aspirin stimulation. Aspirin 133-140 interferon gamma Homo sapiens 0-9 27672296-16 2016 Additionally, CD patients had the highest IFNgamma levels (8.5 +- 4.1). Cadmium 14-16 interferon gamma Homo sapiens 42-50 27658027-2 2016 In this context interferon gamma (IFNgamma) is the major host protective cytokine against chlamydial infections because it induces the expression of the host enzyme, indoleamine 2,3-dioxygenase 1, that degrades tryptophan, thereby restricting bacterial replication. Tryptophan 211-221 interferon gamma Homo sapiens 16-43 27658027-9 2016 The reduced tryptophan levels in HeLa cells have a biological consequence; akin to the previously described effect of IFNgamma, tryptophan starvation protects C. trachomatis from clearance by doxycycline in HeLa but not C33A cells. Tryptophan 128-138 interferon gamma Homo sapiens 118-126 27653678-0 2016 IFN-gamma Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages. Lysine 28-34 interferon gamma Homo sapiens 0-9 27653678-3 2016 By using transcriptomic and epigenomic analysis, we found that stable repression of a small group of genes by IFN-gamma is associated with recruitment of the histone methyltransferase EZH2 and deposition of the negative mark histone 3 lysine 27 trimethylation (H3K27me3) at their promoters. Lysine 235-241 interferon gamma Homo sapiens 110-119 27695456-5 2016 In situations of chronic inflammation complicating allo-HSCT, such as graft-versus-host disease or infections, PGF seems to be essentially the result of a sustained impairment of hematopoietic stem cells (HSC) self-renewal and proliferation caused by inflammatory mediators, such as interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha, and of induction of apoptosis through the Fas/Fas ligand pathway. Prostaglandins F 111-114 interferon gamma Homo sapiens 283-299 27672296-25 2016 Mucosal high levels of tTG and IFNgamma mRNA may predict the development of CD more than GS with high specificity, despite an expected low sensitivity. Cadmium 76-78 interferon gamma Homo sapiens 31-39 27703455-7 2016 We found that CT enhances the inhibitory function of CD4+CD25+ T cells, CD4+, and CD8+ T cell proliferation and IFNgamma production are strongly inhibited by CD4+CD25+ T cells pre-treated with cAMP-elevating agents. Cyclic AMP 193-197 interferon gamma Homo sapiens 112-120 27448806-10 2016 Moreover, increased production of IL2, IFN-gamma and TNF-alpha was found in T cells of NF1 patients upon phorbol-12-myristate acetate (PMA) stimulation compared to healthy controls. phorbol-12-myristate acetate 105-133 interferon gamma Homo sapiens 39-48 27598576-6 2016 Furthermore, IFNgamma-induced priming of microglial ROS production was reduced upon blockade of Kir2.1 inward rectifier K+ channels with ML133. Reactive Oxygen Species 52-55 interferon gamma Homo sapiens 13-21 27626449-5 2016 Moreover, TMC nanoparticles induced clear polarization towards a Th1 response, indicated by IgG2c/IgG1 ratios above unity and enhanced numbers of antigen-specific IFN-gamma producing T-cells in the spleen. tmc 10-13 interferon gamma Homo sapiens 163-172 27598576-0 2016 Mechanisms Underlying Interferon-gamma-Induced Priming of Microglial Reactive Oxygen Species Production. Reactive Oxygen Species 69-92 interferon gamma Homo sapiens 22-38 27598576-3 2016 Here, we demonstrate that priming of microglia with interferon-gamma (IFN gamma) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. Reactive Oxygen Species 118-141 interferon gamma Homo sapiens 52-68 27598576-3 2016 Here, we demonstrate that priming of microglia with interferon-gamma (IFN gamma) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. Reactive Oxygen Species 118-141 interferon gamma Homo sapiens 70-79 27598576-3 2016 Here, we demonstrate that priming of microglia with interferon-gamma (IFN gamma) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. Reactive Oxygen Species 143-146 interferon gamma Homo sapiens 52-68 27598576-3 2016 Here, we demonstrate that priming of microglia with interferon-gamma (IFN gamma) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. Reactive Oxygen Species 143-146 interferon gamma Homo sapiens 70-79 27598576-3 2016 Here, we demonstrate that priming of microglia with interferon-gamma (IFN gamma) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. Adenosine Triphosphate 188-191 interferon gamma Homo sapiens 52-68 27598576-3 2016 Here, we demonstrate that priming of microglia with interferon-gamma (IFN gamma) substantially enhanced production of reactive oxygen species (ROS) following stimulation of microglia with ATP. Adenosine Triphosphate 188-191 interferon gamma Homo sapiens 70-79 27358381-1 2016 BACKGROUND: Neopterin is produced by activated macrophages upon stimulation with interferon-gamma (IFN-gamma) and thus, elevated neopterin concentrations in patients indicate cellular inate immune response. Neopterin 12-21 interferon gamma Homo sapiens 81-97 27358381-1 2016 BACKGROUND: Neopterin is produced by activated macrophages upon stimulation with interferon-gamma (IFN-gamma) and thus, elevated neopterin concentrations in patients indicate cellular inate immune response. Neopterin 12-21 interferon gamma Homo sapiens 99-108 27216712-12 2016 The immunostimulatory effects of IPs on the NK cells was assessed by the production of TNF-alpha alone as IFN-gamma was undetectable. IPS 33-36 interferon gamma Homo sapiens 106-115 27448806-10 2016 Moreover, increased production of IL2, IFN-gamma and TNF-alpha was found in T cells of NF1 patients upon phorbol-12-myristate acetate (PMA) stimulation compared to healthy controls. Tetradecanoylphorbol Acetate 135-138 interferon gamma Homo sapiens 39-48 27269178-0 2016 Vitamin D status and its modulatory effect on interferon gamma and interleukin-10 production by peripheral blood mononuclear cells in culture. Vitamin D 0-9 interferon gamma Homo sapiens 46-62 27269178-1 2016 OBJECTIVES: We aimed to investigate the influence of vitamin D on the production of the pro-inflammatory cytokine, interferon gamma (IFN-gamma), and the anti-inflammatory cytokine, interleukin-10 (IL-10), in peripheral blood mononuclear cell (PBMC) cultures. Vitamin D 53-62 interferon gamma Homo sapiens 115-142 27269178-7 2016 In culture, vitamin D inhibited IFN-gamma production and increased IL-10 production by PBMCs. Vitamin D 12-21 interferon gamma Homo sapiens 32-41 27269178-9 2016 CONCLUSIONS: This study demonstrates that vitamin D modulates IFN-gamma and IL-10 production and provides a rationale for evaluating vitamin D as an immunomodulatory agent. Vitamin D 42-51 interferon gamma Homo sapiens 62-71 27269180-9 2016 In the correlation analysis, IFN-gamma was closely related to the concentration of alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, lactate dehydrase (LDH), triglyceride and fibrinogen, while IL-10 was associated with platelet count. Bilirubin 149-158 interferon gamma Homo sapiens 29-38 27421739-2 2016 Interferon (IFN)-gamma treatment primes MSC immunosuppression partially through induction of Indoleamine 2,3-dioxygenase (IDO1), which depletes tryptophan necessary to support proliferation of activated T cells. Tryptophan 144-154 interferon gamma Homo sapiens 0-22 27269180-9 2016 In the correlation analysis, IFN-gamma was closely related to the concentration of alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, lactate dehydrase (LDH), triglyceride and fibrinogen, while IL-10 was associated with platelet count. Triglycerides 185-197 interferon gamma Homo sapiens 29-38 27269180-10 2016 When split the patients into two groups according to the cytokine levels, patients with high IFN-gamma presented higher level of ALT, AST, bilirubin, LDH, triglyceride, and fibrinogen, while patients with high IL-10 presented much lower hemoglobin and platelet count. Bilirubin 139-148 interferon gamma Homo sapiens 93-102 27269180-10 2016 When split the patients into two groups according to the cytokine levels, patients with high IFN-gamma presented higher level of ALT, AST, bilirubin, LDH, triglyceride, and fibrinogen, while patients with high IL-10 presented much lower hemoglobin and platelet count. Triglycerides 155-167 interferon gamma Homo sapiens 93-102 26812800-5 2016 Dydrogesterone treatment of women at risk of pre-term delivery results in increased PIBF production and IL-10 concentrations, and lower concentrations of IFNgamma and could be effective for prevention or treatment of pre-term labor. Dydrogesterone 0-14 interferon gamma Homo sapiens 154-162 27328412-6 2016 Seven days after transplant, serum blood IFN-gamma levels were significantly lower in the CTLA-4 Ig with reparixin treatment group compared to controls. reparixin 105-114 interferon gamma Homo sapiens 41-50 27474077-6 2016 Conversely, IFN-gamma synthesis and IL-12R synthesis were rescued by the addition of exogenous superoxide via the paramagnetic superoxide donor potassium dioxide or superoxide-sufficient dendritic cells. Superoxides 95-105 interferon gamma Homo sapiens 12-21 27251370-6 2016 Clinical and non-clinical evidence supports the view that the usual dose of oseltamivir suppresses pro-inflammatory cytokines such as interferon-gamma, interleukin-6, and tumour necrosis factor-alpha almost completely with partial suppression of viral shedding in human influenza virus infection experiment. Oseltamivir 76-87 interferon gamma Homo sapiens 134-150 27474077-6 2016 Conversely, IFN-gamma synthesis and IL-12R synthesis were rescued by the addition of exogenous superoxide via the paramagnetic superoxide donor potassium dioxide or superoxide-sufficient dendritic cells. Superoxides 127-137 interferon gamma Homo sapiens 12-21 27474077-6 2016 Conversely, IFN-gamma synthesis and IL-12R synthesis were rescued by the addition of exogenous superoxide via the paramagnetic superoxide donor potassium dioxide or superoxide-sufficient dendritic cells. potassium superoxide 144-161 interferon gamma Homo sapiens 12-21 27474077-6 2016 Conversely, IFN-gamma synthesis and IL-12R synthesis were rescued by the addition of exogenous superoxide via the paramagnetic superoxide donor potassium dioxide or superoxide-sufficient dendritic cells. Superoxides 127-137 interferon gamma Homo sapiens 12-21 27095417-6 2016 RESULTS: Dexamethasone had an anti-inflammatory effect on IFNgamma + TNFalpha stimulated and osteoarthritic synovium, likely due to suppression of pro-inflammatory M(IFNgamma + TNFalpha) macrophages while enhancing anti-inflammatory M(IL4) and M(IL10) macrophages. Dexamethasone 9-22 interferon gamma Homo sapiens 58-66 27095417-6 2016 RESULTS: Dexamethasone had an anti-inflammatory effect on IFNgamma + TNFalpha stimulated and osteoarthritic synovium, likely due to suppression of pro-inflammatory M(IFNgamma + TNFalpha) macrophages while enhancing anti-inflammatory M(IL4) and M(IL10) macrophages. Dexamethasone 9-22 interferon gamma Homo sapiens 166-174 27299362-7 2016 Post thawing, IFNgamma licensed MSCs inhibit T cell proliferation as well as fresh MSCs and this effect can be blocked by 1-methyl Tryptophan, an Indoleamine 2,3-dioxygenase (IDO) inhibitor. 1-methyltryptophan 122-141 interferon gamma Homo sapiens 14-22 28390203-10 2016 The addition of stannous fluoride suppressed production of TNF-a, IFN-g, IL12p70, IL10, IL-1b, IL2, and IL-6, and also increased secretion of Il-8 in dose response fashion. Tin Fluorides 16-33 interferon gamma Homo sapiens 66-71 27499022-3 2016 By adding a neo-N-glycan on IFN-gammaR2 subunit, this mutation blocks IFN-gamma activity by unknown mechanisms. neo-n-glycan 12-24 interferon gamma Homo sapiens 28-37 27575372-6 2016 By genetically silencing p47phox, IFN-gamma-induced ROS and mimic ETosis were significantly attenuated. Reactive Oxygen Species 52-55 interferon gamma Homo sapiens 34-43 27575372-8 2016 Furthermore, ROS promoted IFN-gamma-induced mimic ETosis in cooperation with autophagy. Reactive Oxygen Species 13-16 interferon gamma Homo sapiens 26-35 27575372-9 2016 These findings further demonstrate that ROS regulates IFN-gamma-induced mimic ETosis in lung epithelial malignancy. Reactive Oxygen Species 40-43 interferon gamma Homo sapiens 54-63 27400720-2 2016 However, Chlamydia can experience amino acid starvation when the human host cell in which the bacteria reside is exposed to interferon gamma (IFN-gamma), which leads to a tryptophan (Trp)-limiting environment via induction of the enzyme indoleamine-2,3-dioxygenase (IDO). Tryptophan 171-181 interferon gamma Homo sapiens 124-151 27400720-2 2016 However, Chlamydia can experience amino acid starvation when the human host cell in which the bacteria reside is exposed to interferon gamma (IFN-gamma), which leads to a tryptophan (Trp)-limiting environment via induction of the enzyme indoleamine-2,3-dioxygenase (IDO). Tryptophan 183-186 interferon gamma Homo sapiens 124-151 27131864-6 2016 Relative to other subjects, patients with PGF had significantly higher proportions of stimulated CD4(+) and CD8(+) T cells that produced IFN-gamma (Th1 and Tc1 cells) but notably decreased proportions of IL-4-producing T cells (Th2 and Tc2 cells), resulting in a shift of the IFN-gamma/IL-4 ratio towards a type 1 response and an elevated percentage of activated CD8(+) T cells. Prostaglandins F 42-45 interferon gamma Homo sapiens 276-285 27509021-7 2016 The immune-modulatory effect of BPA was assessed by evaluating the cell proliferation and the levels of interferon-gamma (IFN-gamma), interleukin-4 (IL-4), interleukin-10 (IL-10) and interleukin-13 (IL-13) secreted by PBMCs. bisphenol A 32-35 interferon gamma Homo sapiens 104-120 27509021-7 2016 The immune-modulatory effect of BPA was assessed by evaluating the cell proliferation and the levels of interferon-gamma (IFN-gamma), interleukin-4 (IL-4), interleukin-10 (IL-10) and interleukin-13 (IL-13) secreted by PBMCs. bisphenol A 32-35 interferon gamma Homo sapiens 122-131 27486476-4 2016 RESULTS: IFNgamma triggered apoptosis of CLS-354 and RPMI 2650 cells, enhanced the protein expression and activation of indoleamine 2,3-dioxygenase (IDO), and suppressed the basal expression of heme oxygenase-1(HO-1). Chlorine 41-44 interferon gamma Homo sapiens 9-17 27486476-5 2016 Interestingly, IFNgamma induced the loss of mitochondrial membrane potential (Deltapsim) and increased accumulation of reactive oxygen species (ROS). Reactive Oxygen Species 119-142 interferon gamma Homo sapiens 15-23 27486476-5 2016 Interestingly, IFNgamma induced the loss of mitochondrial membrane potential (Deltapsim) and increased accumulation of reactive oxygen species (ROS). Reactive Oxygen Species 144-147 interferon gamma Homo sapiens 15-23 27486476-7 2016 Furthermore, IFNgamma was found to trigger endoplasmic reticulum (ER) stress as evidenced by the cleavage of caspase-4 and activation of protein kinase RNA-like endoplasmic reticulum kinase (PERK) and inositol-requiring-1alpha (IRE1alpha) pathways. Inositol 201-209 interferon gamma Homo sapiens 13-21 27397088-4 2016 Calcitriol significantly reduced the production of IL-2, IL-4, IL-6, and IFN-gamma, while interferon-beta significantly reduced production of IL-6 and TNF-alpha, and increased IL-10. Calcitriol 0-10 interferon gamma Homo sapiens 73-82 27540379-8 2016 Similar to microglia and macrophages, these cells are highly responsive to IFN-gamma, which upregulates the expression of enzymes, including IDO-1, producing neurotoxic KP metabolites such as quinolinic acid. Quinolinic Acid 192-207 interferon gamma Homo sapiens 75-84 27312110-6 2016 We show that the PI3K/AKT/Foxo1/3 pathway is activated in ex vivo-isolated Tregs from untreated relapsing-remitting MS patients and that blockade of the pathway inhibits IFNgamma secretion and restores the immune suppressive function of Tregs. tregs 75-80 interferon gamma Homo sapiens 170-178 27131864-6 2016 Relative to other subjects, patients with PGF had significantly higher proportions of stimulated CD4(+) and CD8(+) T cells that produced IFN-gamma (Th1 and Tc1 cells) but notably decreased proportions of IL-4-producing T cells (Th2 and Tc2 cells), resulting in a shift of the IFN-gamma/IL-4 ratio towards a type 1 response and an elevated percentage of activated CD8(+) T cells. Prostaglandins F 42-45 interferon gamma Homo sapiens 137-146 27328271-8 2016 Moreover, interferon-gamma played an important role in the production of anti-NA-14 autoantibodies as patients with pSS having anti-NA-14 antibodies exhibited increased serum levels of IP-10 and BAFF. pss 116-119 interferon gamma Homo sapiens 10-26 27349476-2 2016 A recent study by Wang and colleagues identified IFN-gamma as a central effector of CD8 T cell-mediated regulation of glutathione and cysteine metabolism in fibroblasts, which consequently abrogates stromal-induced resistance through modulation of cisplatin intracellular content in ovarian cancer cells. Glutathione 118-129 interferon gamma Homo sapiens 49-58 27349476-2 2016 A recent study by Wang and colleagues identified IFN-gamma as a central effector of CD8 T cell-mediated regulation of glutathione and cysteine metabolism in fibroblasts, which consequently abrogates stromal-induced resistance through modulation of cisplatin intracellular content in ovarian cancer cells. Cysteine 134-142 interferon gamma Homo sapiens 49-58 27349476-2 2016 A recent study by Wang and colleagues identified IFN-gamma as a central effector of CD8 T cell-mediated regulation of glutathione and cysteine metabolism in fibroblasts, which consequently abrogates stromal-induced resistance through modulation of cisplatin intracellular content in ovarian cancer cells. Cisplatin 248-257 interferon gamma Homo sapiens 49-58 27235090-4 2016 Fortepren( ) treatment of patients with a high incidence of recurrent herpes infection led to an increase in the interferon-producing ability of leucocytes stimulated with NDV, as well as in the production of key cytokines (IL-1beta, IL-15, MIP-1alpha, IFN-gamma, IL-12 (p40), TNF-alpha, IFN-alpha2, IL-12 (p70), IL-6) taking part in the protection against viral infection. fortepren 0-9 interferon gamma Homo sapiens 253-262 27487850-4 2016 Moreover, the combination of LMFHS-Fucox dramatically enhanced the intestinal epithelial barrier and immune function against the lipopolysaccharide effect by inhibiting IL-1beta and TNF-alpha and promoting IL-10 and IFN-gamma. lmfhs-fucox 29-40 interferon gamma Homo sapiens 216-225 26073670-7 2016 All of the dipeptide-containing diets reduced pro-inflammatory cytokine concentrations in the mucosa (TNF-alpha, IFN-gamma). Dipeptides 11-20 interferon gamma Homo sapiens 113-122 27235588-0 2016 IL-2, IL-4, IFN-gamma or TNF-alpha enhances BAFF-stimulated cell viability and survival by activating Erk1/2 and S6K1 pathways in neoplastic B-lymphoid cells. baff 44-48 interferon gamma Homo sapiens 12-21 27235588-3 2016 In this study, we exhibited that administration of human soluble BAFF (hsBAFF), IL-2, IL-4, IFN-gamma, or TNF-alpha alone increased cell viability and survival in Raji cells concentration-dependently, yet a more robust viability/survival was seen in the cells co-treatment of IL-2, IL-4, IFN-gamma, or TNF-alpha with hsBAFF, respectively. baff 65-69 interferon gamma Homo sapiens 288-297 27235588-5 2016 These findings indicate that IL-2, IL-4, IFN-gamma or TNF-alpha enhances BAFF-stimulated cell viability/survival by activating Erk1/2 and S6K1 signaling in neoplastic B-lymphoid cells. baff 73-77 interferon gamma Homo sapiens 41-50 27235588-6 2016 Our data suggest that modulation of IL-2, IL-4, IFN-gamma and/or TNF-alpha levels, or inhibitors of Erk1/2 or S6K1 may be a new approach to prevent BAFF-induced aggressive B-cell malignancies. baff 148-152 interferon gamma Homo sapiens 48-57 27446273-10 2016 Treatment with capsaicin increased phagocytosis of MG-63 cells by dendritic cells (DCs), and these MG-63-loaded DCs could efficiently stimulate the secretion of IFN-gamma by lymphocytes. Capsaicin 15-24 interferon gamma Homo sapiens 161-170 27057737-7 2016 Stimulation with R-848 resulted in significant higher secretion of TNFalpha, IL-6, IL-10, IL-12/IL-23p40, IL-12p70, and IFN-gamma. resiquimod 17-22 interferon gamma Homo sapiens 120-129 27695641-3 2016 Chlamydial dependence on host-provided tryptophan underlies a major host defense mechanism against the bacterium; namely, the induction of the host tryptophan-catabolizing enzyme, indoleamine 2,3- dioxygenase (IDO1) by interferon gamma (IFNgamma), which leads to eradication of C. trachomatis by tryptophan starvation. Tryptophan 39-49 interferon gamma Homo sapiens 237-245 27695641-3 2016 Chlamydial dependence on host-provided tryptophan underlies a major host defense mechanism against the bacterium; namely, the induction of the host tryptophan-catabolizing enzyme, indoleamine 2,3- dioxygenase (IDO1) by interferon gamma (IFNgamma), which leads to eradication of C. trachomatis by tryptophan starvation. Tryptophan 148-158 interferon gamma Homo sapiens 237-245 27695641-3 2016 Chlamydial dependence on host-provided tryptophan underlies a major host defense mechanism against the bacterium; namely, the induction of the host tryptophan-catabolizing enzyme, indoleamine 2,3- dioxygenase (IDO1) by interferon gamma (IFNgamma), which leads to eradication of C. trachomatis by tryptophan starvation. Tryptophan 148-158 interferon gamma Homo sapiens 237-245 27307103-7 2016 In all cell models, interferon-gamma activation leads to up-regulation of interleukin-12 and nitrite production. Nitrites 93-100 interferon gamma Homo sapiens 20-36 27012234-8 2016 The concentrations of IFN-gamma and IL-4, which represent Th1-type and Th2-type cytokine responses, were significantly higher (p < 0.05) in the rSPVOmpL- vaccinated group than in the other three groups. rspvompl 147-155 interferon gamma Homo sapiens 22-31 27472280-0 2016 Revisiting the Heterogeneous IFN-gamma Response of Bacille of Calmette-Guerin (BCG)-Revaccinated Healthy Volunteers in a Randomized Controlled Trial: Effect of the Body Mass Index and of the IFNG+874 A/T Polymorphism. bacille 51-58 interferon gamma Homo sapiens 29-38 27472280-0 2016 Revisiting the Heterogeneous IFN-gamma Response of Bacille of Calmette-Guerin (BCG)-Revaccinated Healthy Volunteers in a Randomized Controlled Trial: Effect of the Body Mass Index and of the IFNG+874 A/T Polymorphism. calmette-guerin 62-77 interferon gamma Homo sapiens 29-38 27472280-0 2016 Revisiting the Heterogeneous IFN-gamma Response of Bacille of Calmette-Guerin (BCG)-Revaccinated Healthy Volunteers in a Randomized Controlled Trial: Effect of the Body Mass Index and of the IFNG+874 A/T Polymorphism. bcg 79-82 interferon gamma Homo sapiens 29-38 27467256-5 2016 Interestingly, the surface expression of MHC-I, MHC-II, and PD-L1 was up-regulated in response to IFNgamma more often in lung cancer cell lines sensitive to erlotinib, but only expression of PD-L1 was inhibited by erlotinib. Erlotinib Hydrochloride 157-166 interferon gamma Homo sapiens 98-106 27467256-4 2016 Erlotinib up-regulated MHC-I and MHC-II proteins on IFNgamma treated keratinocytes but abrogated IFNgamma-induced expression of PD-L1, suggesting the potential role of infiltrating autoreactive T cells in the damage of keratinocytes in affected skin. Erlotinib Hydrochloride 0-9 interferon gamma Homo sapiens 52-60 27312202-12 2016 Montelukast-treated mDCs suppressed IFN-gamma and IL-13 production by T cells. montelukast 0-11 interferon gamma Homo sapiens 36-45 27467256-5 2016 Interestingly, the surface expression of MHC-I, MHC-II, and PD-L1 was up-regulated in response to IFNgamma more often in lung cancer cell lines sensitive to erlotinib, but only expression of PD-L1 was inhibited by erlotinib. Erlotinib Hydrochloride 214-223 interferon gamma Homo sapiens 98-106 27467256-4 2016 Erlotinib up-regulated MHC-I and MHC-II proteins on IFNgamma treated keratinocytes but abrogated IFNgamma-induced expression of PD-L1, suggesting the potential role of infiltrating autoreactive T cells in the damage of keratinocytes in affected skin. Erlotinib Hydrochloride 0-9 interferon gamma Homo sapiens 97-105 27456316-6 2016 Ultimately, GML treatment potently reduced TCR-induced production of IL-2, IFN-gamma, TNF-alpha, and IL-10. monolaurin 12-15 interferon gamma Homo sapiens 75-84 27459633-1 2016 For rapid screening and quantification of an antisera antibody, a nanometer bithiophene-based conductive biolinker can enhanced signal performance and can be used to verify the interaction of an anti-IFN-gamma antibody with an IFN-gamma protein. 2,2'-Bithiophene 76-87 interferon gamma Homo sapiens 200-209 27427967-6 2016 Priming with BCG-GagM and boosting with MVA-GagM elicited higher Gag-specific IFN-gamma ELISPOT responses than the BCG-GagM only and MVA-GagM only homologous vaccination regimens. Glycosaminoglycans 17-20 interferon gamma Homo sapiens 78-87 27459633-1 2016 For rapid screening and quantification of an antisera antibody, a nanometer bithiophene-based conductive biolinker can enhanced signal performance and can be used to verify the interaction of an anti-IFN-gamma antibody with an IFN-gamma protein. 2,2'-Bithiophene 76-87 interferon gamma Homo sapiens 227-236 27459633-5 2016 We compared the response and concentration of the anti-IFN-gamma antibody on a bithiophene-coated and dextran-coated biochip as well as on different thickness-modified surfaces under SPR relevant conditions. 2,2'-Bithiophene 79-90 interferon gamma Homo sapiens 55-64 27459633-5 2016 We compared the response and concentration of the anti-IFN-gamma antibody on a bithiophene-coated and dextran-coated biochip as well as on different thickness-modified surfaces under SPR relevant conditions. Dextrans 102-109 interferon gamma Homo sapiens 55-64 27459633-6 2016 The results indicate that a response to IFN-gamma molecules immobilized on a sensor using a bithiophene biolinker improved more than 8-fold when compared to that of a sensor using a dextran biolinker. 2,2'-Bithiophene 92-103 interferon gamma Homo sapiens 40-49 27459633-6 2016 The results indicate that a response to IFN-gamma molecules immobilized on a sensor using a bithiophene biolinker improved more than 8-fold when compared to that of a sensor using a dextran biolinker. Dextrans 182-189 interferon gamma Homo sapiens 40-49 27493792-7 2016 While serum levels were elevated in patients with pSS compared to healthy controls, unexpectedly, the levels of 4 proinflammatory cytokines-interferon-gamma-induced protein-10 (IP-10) (p=0.019), tumour necrosis factor-alpha (p=0.046), lymphotoxin-alpha (p=0.034) and interferon-gamma (IFN-gamma) (p=0.022)-were inversely related to patient-reported levels of fatigue. pss 50-53 interferon gamma Homo sapiens 140-156 27493792-8 2016 A regression model predicting fatigue levels in pSS based on cytokine levels, disease-specific and clinical parameters, as well as anxiety, pain and depression, revealed IP-10, IFN-gamma (both inversely), pain and depression (both positively) as the most important predictors of fatigue. pss 48-51 interferon gamma Homo sapiens 177-186 27067196-6 2016 Children randomly assigned to receive DP had higher frequencies of blood-stage specific CD4(+) T cells coproducing interleukin-2 and tumor necrosis factor alpha (P = .003), which were associated with protection from subsequent clinical malaria and parasitemia, and fewer blood-stage specific CD4(+) T cells coproducing interleukin-10 and interferon gamma (P = .001), which were associated with increased risk of malaria. dp 38-40 interferon gamma Homo sapiens 338-354 27405665-4 2016 Curcumin treatment polarized surviving M-MDSCs toward CCR7(+) Dectin-1(-)M1 cells, accompanied by IFN-gamma production and cytolytic function in T cells. Curcumin 0-8 interferon gamma Homo sapiens 98-107 27271568-2 2016 However, the exact role of SP-A and the mechanism by which SP-A affects IFN-gamma-induced activation of alveolar macrophages (aMphis) remains unknown. methyl 2-(((2-aminoethyl)amino)methyl)-6-carboxylpyridinehistidinate 126-132 interferon gamma Homo sapiens 72-81 27231239-5 2016 pLTA inhibited C3 expression through the inhibition of the phosphorylation of p65 and p38 in the TNF-alpha-treated cells, while the inhibition of STAT1/2 and JAK2 phosphorylation by pLTA contributed to the reduction of C3 in IFN-gamma-treated cells. plta 0-4 interferon gamma Homo sapiens 225-234 26302867-0 2016 Hexabromocyclododecane and tetrabromobisphenol A alter secretion of interferon gamma (IFN-gamma) from human immune cells. hexabromocyclododecane 0-22 interferon gamma Homo sapiens 68-95 26302867-0 2016 Hexabromocyclododecane and tetrabromobisphenol A alter secretion of interferon gamma (IFN-gamma) from human immune cells. tetrabromobisphenol A 27-48 interferon gamma Homo sapiens 68-95 26302867-4 2016 This study examines whether HBCD and TBBPA affect the secretion of IFN-gamma from increasingly complex preparations of human immune cells-purified NK cells, monocyte-depleted (MD) peripheral blood mononuclear cells (PBMCs), and PBMCs. hexabromocyclododecane 28-32 interferon gamma Homo sapiens 67-76 26302867-4 2016 This study examines whether HBCD and TBBPA affect the secretion of IFN-gamma from increasingly complex preparations of human immune cells-purified NK cells, monocyte-depleted (MD) peripheral blood mononuclear cells (PBMCs), and PBMCs. tetrabromobisphenol A 37-42 interferon gamma Homo sapiens 67-76 26302867-8 2016 In contrast, TBBPA tended to decrease secretion of IFN-gamma from NK cells, MD-PBMCs, and PBMCs. tetrabromobisphenol A 13-18 interferon gamma Homo sapiens 51-60 27076449-5 2016 Rapamycin enhanced expansion of peripheral antigen-specific CD8 T cells and IFNgamma production following ex vivo antigen stimulation. Sirolimus 0-9 interferon gamma Homo sapiens 76-84 27076449-7 2016 Rapamycin increased IFNgamma production capacity in peripheral and tumor-infiltrating CD8 T cells. Sirolimus 0-9 interferon gamma Homo sapiens 20-28 27076449-9 2016 Rapamycin also enhanced IFNgamma or PD-L1 mAb treatment-associated induction of MHC class I expression on MOC1 tumor cells, an effect abrogated by depleting infiltrating CD8 T cells from the tumor microenvironment. Sirolimus 0-9 interferon gamma Homo sapiens 24-32 27231239-4 2016 In the current study, we found that lipoteichoic acid isolated from Lactobacillus plantarum K8 (pLTA) inhibited tumor necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma)-mediated C3 mRNA and protein expression in HaCaT cells. lipoteichoic acid 36-53 interferon gamma Homo sapiens 173-182 26948076-10 2016 The combination of IL-21 and IFN-gamma baseline expression closely predicted individual clinical glucocorticosteroid responses at 16 weeks of treatment. glucocorticosteroid 97-116 interferon gamma Homo sapiens 29-38 27108964-9 2016 Generalized multifactor dimensionality reduction method (GMDR) testing revealed high risk combinations of several genotypes in IFN-gamma & IL-12 genes. Adenosine Monophosphate 138-141 interferon gamma Homo sapiens 127-136 27306067-12 2016 1alpha,25-dihydroxyvitamin D3 decreased interferon-gamma-expressing Tc1 (P < 0.05), but had no effect on Tc17 or Tcreg. Calcitriol 0-29 interferon gamma Homo sapiens 40-56 27306067-15 2016 Vitamin D may have a limited effect on CD8+ T cells by decreasing interferon-gamma expression. Vitamin D 0-9 interferon gamma Homo sapiens 66-82 26980802-4 2016 We report a novel role of retinoic acid in an inflammatory setup, where retinoic acid-primed dendritic cells (retinoic acid-monocyte-derived dendritic cells) up-regulated CCR9(+)T cells, which were observed to express high levels of IFN-gamma in the presence of Th1/Th17 conditions. Tretinoin 26-39 interferon gamma Homo sapiens 233-242 26980802-4 2016 We report a novel role of retinoic acid in an inflammatory setup, where retinoic acid-primed dendritic cells (retinoic acid-monocyte-derived dendritic cells) up-regulated CCR9(+)T cells, which were observed to express high levels of IFN-gamma in the presence of Th1/Th17 conditions. Tretinoin 72-85 interferon gamma Homo sapiens 233-242 26980802-4 2016 We report a novel role of retinoic acid in an inflammatory setup, where retinoic acid-primed dendritic cells (retinoic acid-monocyte-derived dendritic cells) up-regulated CCR9(+)T cells, which were observed to express high levels of IFN-gamma in the presence of Th1/Th17 conditions. Tretinoin 72-85 interferon gamma Homo sapiens 233-242 26980802-7 2016 Experiments with naive CD4(+) T cells, activated in the presence of Th1/Th17 conditions and absence of DCs, indicated that retinoic acid inhibited IFN-gamma and IL-17 expression on T cells. Tretinoin 123-136 interferon gamma Homo sapiens 147-156 27295554-8 2016 These findings suggest that DICER/Let-7 activity opposes IFN-gamma-induced, immunostimulatory M1-like TAM activation, with potential therapeutic implications. tam 102-105 interferon gamma Homo sapiens 57-66 27122150-0 2016 Retinyl Palmitate Supplementation Modulates T-bet and Interferon Gamma Gene Expression in Multiple Sclerosis Patients. retinol palmitate 0-17 interferon gamma Homo sapiens 54-70 27122150-9 2016 This study provides information regarding the decreased gene expression of IFN-gamma and T-bet in MS by retinyl palmitate supplementation. retinol palmitate 104-121 interferon gamma Homo sapiens 75-84 27142560-11 2016 Importantly, dexamethasone augmented MSCs mediated inhibition of both IL-12 and IL-2 induced CD69 expression and IFNgamma production, as well as IL-2 induced STAT5 phosphorylation. Dexamethasone 13-26 interferon gamma Homo sapiens 113-121 27020921-9 2016 IL-6 and IL-10 levels significantly increased, while IFN-gamma level decreased in both groups during the surgery and 3 days after the surgery compared to those before the surgery; 2 weeks after the surgery, IL-6 and IL-10 levels in the MIE group recovered to the pre-operative levels (all P < 0.05). mie 236-239 interferon gamma Homo sapiens 53-62 26995677-0 2016 Prostaglandin D2 is a novel repressor of IFNgamma induced indoleamine-2,3-dioxygenase via the DP1 receptor and cAMP pathway. Prostaglandin D2 0-16 interferon gamma Homo sapiens 41-49 27235355-3 2016 IFN-gamma induced MHC class II and upregulated ICAM-1; the axolemma-like signal 8-bromo cyclic adenosine monophosphate (8 Br cAMP) with IFN-gamma inhibited expression. 8-Bromo Cyclic Adenosine Monophosphate 80-118 interferon gamma Homo sapiens 136-145 26995677-0 2016 Prostaglandin D2 is a novel repressor of IFNgamma induced indoleamine-2,3-dioxygenase via the DP1 receptor and cAMP pathway. Cyclic AMP 111-115 interferon gamma Homo sapiens 41-49 26995677-3 2016 Previously we demonstrated that cyclooxygenase derived metabolites of arachidonic acid inhibited the interferon-gamma mediated induction of IDO in both THP-1 cells and human monocytes. Arachidonic Acid 70-86 interferon gamma Homo sapiens 101-117 27622052-4 2016 This hypothesis is currently being tested in clinical trials and we have reported that treatment of cancer patients with PEG-rHuIL-10 results in inhibition and regression of tumor growth as well as increased serum IFNgamma. peg-rhuil-10 121-133 interferon gamma Homo sapiens 214-222 27622052-5 2016 We have continued to assess PEG-rIL-10"s pleiotropic effects and report that treatment of tumor-bearing mice and humans with PEG-rIL-10 increases intratumoral indoleamine 2, 3-dioxygenase (IDO) in an IFNgamma-dependent manner. peg-ril-10 125-135 interferon gamma Homo sapiens 200-208 27622052-7 2016 Additional investigation indicates that PEG-rIL-10 inhibits TGFbeta/IL-2-dependent in vitro polarization of FoxP3(+)CD4(+) Tregs and potentiates IFNgamma(+)T-bet(+)CD4(+) T cells. peg-ril-10 40-50 interferon gamma Homo sapiens 145-153 27030576-1 2016 BACKGROUND: The ability of interferon-gamma release assays to predict the development of TB has been investigated in many studies, but few cases develop TB during follow-up limiting the generalisation of results. Terbium 89-91 interferon gamma Homo sapiens 27-43 27303033-5 2016 We demonstrate the utility of this microfluidic assay with natural killer cells interacting with tumor cells, and our findings suggest a possible role for the strength of early calcium signaling in selective coordination of subsequent cytotoxicity and IFN-gamma production. Calcium 177-184 interferon gamma Homo sapiens 252-261 26765255-13 2016 Pregnant women with IGRA(+)/TST(-) discordance had less IFN-gamma and IL-2 than those with concordant-positive results and may represent an especially high-risk subset for the development of active TB postpartum. Terbium 198-200 interferon gamma Homo sapiens 56-65 27071416-1 2016 Interferon-gamma inducible human guanylate binding protein-1 (hGBP1) shows a unique characteristic that hydrolyses GTP to a mixture of GDP and GMP through successive cleavages, with GMP being the major product. Guanosine Triphosphate 115-118 interferon gamma Homo sapiens 0-16 27071416-1 2016 Interferon-gamma inducible human guanylate binding protein-1 (hGBP1) shows a unique characteristic that hydrolyses GTP to a mixture of GDP and GMP through successive cleavages, with GMP being the major product. Guanosine Diphosphate 135-138 interferon gamma Homo sapiens 0-16 27071416-1 2016 Interferon-gamma inducible human guanylate binding protein-1 (hGBP1) shows a unique characteristic that hydrolyses GTP to a mixture of GDP and GMP through successive cleavages, with GMP being the major product. guanosine 5'-monophosphorothioate 143-146 interferon gamma Homo sapiens 0-16 27071416-1 2016 Interferon-gamma inducible human guanylate binding protein-1 (hGBP1) shows a unique characteristic that hydrolyses GTP to a mixture of GDP and GMP through successive cleavages, with GMP being the major product. guanosine 5'-monophosphorothioate 182-185 interferon gamma Homo sapiens 0-16 27235355-3 2016 IFN-gamma induced MHC class II and upregulated ICAM-1; the axolemma-like signal 8-bromo cyclic adenosine monophosphate (8 Br cAMP) with IFN-gamma inhibited expression. 8-Bromo Cyclic Adenosine Monophosphate 80-118 interferon gamma Homo sapiens 0-9 27235355-3 2016 IFN-gamma induced MHC class II and upregulated ICAM-1; the axolemma-like signal 8-bromo cyclic adenosine monophosphate (8 Br cAMP) with IFN-gamma inhibited expression. Cyclic AMP 125-129 interferon gamma Homo sapiens 0-9 27235355-3 2016 IFN-gamma induced MHC class II and upregulated ICAM-1; the axolemma-like signal 8-bromo cyclic adenosine monophosphate (8 Br cAMP) with IFN-gamma inhibited expression. Cyclic AMP 125-129 interferon gamma Homo sapiens 136-145 27235355-4 2016 Delaying addition of 8 Br cAMP to SC already exposed to IFN-gamma inhibited ongoing expression; addition of IFN-gamma to SC already exposed to 8 Br cAMP resulted in minimal expression. Cyclic AMP 26-30 interferon gamma Homo sapiens 56-65 27235355-4 2016 Delaying addition of 8 Br cAMP to SC already exposed to IFN-gamma inhibited ongoing expression; addition of IFN-gamma to SC already exposed to 8 Br cAMP resulted in minimal expression. Cyclic AMP 148-152 interferon gamma Homo sapiens 108-117 26986698-5 2016 The mRNA levels of interferon-gamma, tumour necrosis factor-like ligand 1A, interleukin-10, NADPH oxidase 4 and inducible NO synthase were significantly reduced by the trehalose supplementation. Trehalose 168-177 interferon gamma Homo sapiens 19-74 27192116-3 2016 Simultaneous treatment with epacadostat and IFN-gamma plus lipopolysaccharide (LPS) did not change the phenotype of matured human DCs, and as expected decreased the tryptophan breakdown and kynurenine production. Tryptophan 165-175 interferon gamma Homo sapiens 44-53 27192116-3 2016 Simultaneous treatment with epacadostat and IFN-gamma plus lipopolysaccharide (LPS) did not change the phenotype of matured human DCs, and as expected decreased the tryptophan breakdown and kynurenine production. Kynurenine 190-200 interferon gamma Homo sapiens 44-53 26931423-0 2016 17beta-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-gamma/STAT1-dependent miR-7 upregulation. Estradiol 0-16 interferon gamma Homo sapiens 87-96 26498894-2 2016 An alternative to TST is QuantiFERON-TB Gold In-Tube test (QFT-GIT), an in vitro interferon-gamma release assay. tb gold 37-44 interferon gamma Homo sapiens 81-97 27076371-4 2016 Peak levels of 24 cytokines, including IFNgamma, IL6, sgp130, and sIL6R, in the first month after infusion were highly associated with severe CRS. 3-cresol 142-145 interferon gamma Homo sapiens 39-47 27336882-1 2016 Neutralizing anti-interferon-gamma autoantibody (nAIGA)-associated immunodeficiency is an emerging medical issue worldwide. naiga 49-54 interferon gamma Homo sapiens 18-34 27350635-7 2016 RESULTS: The mean absorbance of 10 out of the 12 studied cytokines showed reduction after the therapy with rapamycin including IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, IFN-gamma and TNF-alpha. Sirolimus 107-116 interferon gamma Homo sapiens 179-188 27350635-11 2016 CONCLUSION: Based on the findings of this study, rapamycin has some immunosuppressive effects, such as decreasing IFN -gamma, which can improve the quality of life of the patients with multiple sclerosis. Sirolimus 49-58 interferon gamma Homo sapiens 114-124 26641976-15 2016 When U251 cells were treated with 25 mug/mL L-tryptophan and subsequently challenged with 30 ng/mL of human recombinant IFNgamma, a significant inhibitory effect on cell growth was observed. Tryptophan 44-56 interferon gamma Homo sapiens 120-128 27107845-8 2016 IFN-gamma treatment resulted in striking increases in the expression of disulfide-linked HLA-B27 heavy chains, even in cells with normal ERAP1 expression. Disulfides 72-81 interferon gamma Homo sapiens 0-9 27188901-10 2016 In addition, HMB supplementation was likely (78%-87% likelihood) to reduce interferon-gamma, interleukin 8, CX3CL1, and increase muscle volume for the adductor magnus (77% likelihood) compared to PL. beta-hydroxyisovaleric acid 13-16 interferon gamma Homo sapiens 75-91 26703437-6 2016 Meta-analysis by autoimmune disease type indicated an association between ITP and the IFN-gamma +874 T allele (OR = 1.753, 95% CI = 1.228-2.503, p = 0.002), but not for vasculitis, vitiligo, and auto-immune thyroid disease. Inosine Triphosphate 74-77 interferon gamma Homo sapiens 86-95 27017056-2 2016 One responding clone, Gag68, produced a typical cytotoxic CD8(+)T-cell response: induction of intracellular IFN-gamma, MIP-1alpha, MIP-1beta, and CD107a degranulation. gag68 22-27 interferon gamma Homo sapiens 108-117 27025389-0 2016 Arginine Supplementation Recovered the IFN-gamma-Mediated Decrease in Milk Protein and Fat Synthesis by Inhibiting the GCN2/eIF2alpha Pathway, Which Induces Autophagy in Primary Bovine Mammary Epithelial Cells. Arginine 0-8 interferon gamma Homo sapiens 39-48 26984113-9 2016 The release of interferon-gamma induced protein 10 by primary lymphocytes was significantly reduced following treatment with 1 microm isorhamnetin (P<0 05). 3-methylquercetin 134-146 interferon gamma Homo sapiens 15-31 27179426-6 2016 RESULTS: We found that pitavastatin prevented the CS-induced decrease in angiomotin-like protein 1 (AmotL1)-positive vessels via the activation of LKB1/AMPK signaling and IFN-gamma-induced hyperpermeability of cultured human lung microvascular endothelial cells by maintaining the levels of AmotL1, ZO-1, and claudin-5 expression at the tight junctions. pitavastatin 23-35 interferon gamma Homo sapiens 171-180 27133165-6 2016 CD8(+) T-cell-derived interferon (IFN)gamma controls fibroblast glutathione and cysteine through upregulation of gamma-glutamyltransferases and transcriptional repression of system xc(-) cystine and glutamate antiporter via the JAK/STAT1 pathway. Glutathione 64-75 interferon gamma Homo sapiens 34-43 27133165-6 2016 CD8(+) T-cell-derived interferon (IFN)gamma controls fibroblast glutathione and cysteine through upregulation of gamma-glutamyltransferases and transcriptional repression of system xc(-) cystine and glutamate antiporter via the JAK/STAT1 pathway. Cysteine 80-88 interferon gamma Homo sapiens 34-43 27133165-6 2016 CD8(+) T-cell-derived interferon (IFN)gamma controls fibroblast glutathione and cysteine through upregulation of gamma-glutamyltransferases and transcriptional repression of system xc(-) cystine and glutamate antiporter via the JAK/STAT1 pathway. Cystine 187-194 interferon gamma Homo sapiens 34-43 27133165-6 2016 CD8(+) T-cell-derived interferon (IFN)gamma controls fibroblast glutathione and cysteine through upregulation of gamma-glutamyltransferases and transcriptional repression of system xc(-) cystine and glutamate antiporter via the JAK/STAT1 pathway. Glutamic Acid 199-208 interferon gamma Homo sapiens 34-43 27190695-8 2016 However, exposure to TNF-alpha + IFN-gamma + IL1beta followed by a 5 h exposure to 2 mmol/L H2O2 resulted in a 500% increase in (14)C-PEG leak as well as leak to the luminal mitogen, epidermal growth factor. Polyethylene Glycols 134-137 interferon gamma Homo sapiens 33-42 27109480-8 2016 Sustained treatment of developing T cells with either CQ or AQ suppressed IFN-gamma production in a dose dependent manner and potently inhibited the differentiation of IFN-gamma-producing Th1 cells. Chloroquine 54-56 interferon gamma Homo sapiens 74-83 27109480-8 2016 Sustained treatment of developing T cells with either CQ or AQ suppressed IFN-gamma production in a dose dependent manner and potently inhibited the differentiation of IFN-gamma-producing Th1 cells. Chloroquine 54-56 interferon gamma Homo sapiens 168-177 27109480-8 2016 Sustained treatment of developing T cells with either CQ or AQ suppressed IFN-gamma production in a dose dependent manner and potently inhibited the differentiation of IFN-gamma-producing Th1 cells. Amodiaquine 60-62 interferon gamma Homo sapiens 74-83 27109480-8 2016 Sustained treatment of developing T cells with either CQ or AQ suppressed IFN-gamma production in a dose dependent manner and potently inhibited the differentiation of IFN-gamma-producing Th1 cells. Amodiaquine 60-62 interferon gamma Homo sapiens 168-177 27109480-9 2016 These results demonstrate that CQ and AQ increase the expression level of p21 and inhibit T cell proliferation and the development of IFN-gamma-producing Th1 cells, thereby revealing beneficial roles in treating a wide range of chronic inflammatory diseases mediated by inflammatory T cells. Chloroquine 31-33 interferon gamma Homo sapiens 134-143 27109480-9 2016 These results demonstrate that CQ and AQ increase the expression level of p21 and inhibit T cell proliferation and the development of IFN-gamma-producing Th1 cells, thereby revealing beneficial roles in treating a wide range of chronic inflammatory diseases mediated by inflammatory T cells. Amodiaquine 38-40 interferon gamma Homo sapiens 134-143 27152519-1 2016 BACKGROUND/AIMS: We previously demonstrated that anthocyanin-rich bilberry extract (ARBE) inhibits IFN-gamma-induced signalling and downstream effects in human monocytic cells and ameliorates disease activity in ulcerative colitis (UC) patients. Anthocyanins 49-60 interferon gamma Homo sapiens 99-108 27152519-1 2016 BACKGROUND/AIMS: We previously demonstrated that anthocyanin-rich bilberry extract (ARBE) inhibits IFN-gamma-induced signalling and downstream effects in human monocytic cells and ameliorates disease activity in ulcerative colitis (UC) patients. arbe 84-88 interferon gamma Homo sapiens 99-108 26972221-9 2016 PRMT5 expression was down-regulated in senescent and H2O2-treated macrophages rendering ineffectual induction of MHC II transcription by IFN-gamma. Hydrogen Peroxide 53-57 interferon gamma Homo sapiens 137-146 26795536-3 2016 Here, we show that tryptophan (Trp) suppressed IFN-gamma-mediated hepatic apoptosis in vitro. Tryptophan 19-29 interferon gamma Homo sapiens 47-56 26795536-3 2016 Here, we show that tryptophan (Trp) suppressed IFN-gamma-mediated hepatic apoptosis in vitro. Tryptophan 31-34 interferon gamma Homo sapiens 47-56 26795536-6 2016 IFN-gamma induced ROS in mitochondria by inhibiting complex I and III, but not II. Reactive Oxygen Species 18-21 interferon gamma Homo sapiens 0-9 26795536-7 2016 This ROS generation by IFN-gamma required de novo protein synthesis. Reactive Oxygen Species 5-8 interferon gamma Homo sapiens 23-32 26795536-8 2016 Trp showed relatively weak direct scavenging activity but antagonized IFN-gamma against the suppression of complex I. Tryptophan 0-3 interferon gamma Homo sapiens 70-79 26972221-4 2016 Here we report that following IFN-gamma stimulation, symmetrically dimethylated histone H3 arginine 2 (H3R2Me2s) accumulated on the MHC II promoter along with CIITA. HS 3 88-90 interferon gamma Homo sapiens 30-39 27383709-6 2016 In contrast, budlein A inhibited lymphocyte proliferation and IL-2, IL-10, TGF-beta, and IFN-gamma production, but it did not lead to cell death. budlein A 13-22 interferon gamma Homo sapiens 89-98 26972221-4 2016 Here we report that following IFN-gamma stimulation, symmetrically dimethylated histone H3 arginine 2 (H3R2Me2s) accumulated on the MHC II promoter along with CIITA. arginine 2 91-101 interferon gamma Homo sapiens 30-39 26972221-4 2016 Here we report that following IFN-gamma stimulation, symmetrically dimethylated histone H3 arginine 2 (H3R2Me2s) accumulated on the MHC II promoter along with CIITA. h3r2me2s 103-111 interferon gamma Homo sapiens 30-39 26972221-7 2016 In contrast, PRMT5 silencing or inhibition of PRMT5 activity by methylthioadenosine (MTA) suppressed MHC II transactivation by IFN-gamma. 5'-methylthioadenosine 64-83 interferon gamma Homo sapiens 127-136 26972221-7 2016 In contrast, PRMT5 silencing or inhibition of PRMT5 activity by methylthioadenosine (MTA) suppressed MHC II transactivation by IFN-gamma. 5'-methylthioadenosine 85-88 interferon gamma Homo sapiens 127-136 27041081-6 2016 Both forms of vitamin D reduced the expression of pathogenic Th17 markers and their secretion of pro-inflammatory cytokines (IL-17A, IFN-gamma). Vitamin D 14-23 interferon gamma Homo sapiens 133-142 27002606-5 2016 RESULTS: IFN-gamma and IL-12 cytokine production markedly decreased and that of IL-10 increased after Ag85A M.tb stimulation, however anti TB treatment reconstituted the response in TBDM and PTB patients. Terbium 110-112 interferon gamma Homo sapiens 9-18 26873938-8 2016 IFN-gamma ex vivo caused significant endothelial dysfunction, which was reduced by superoxide anion scavenging. Superoxides 83-99 interferon gamma Homo sapiens 0-9 26363509-11 2016 TNF-alpha and IFN-gamma also enhanced the levels of PE(40:6) and decreased the levels of PE(O-38:6). phosphatidylethanolamine 52-54 interferon gamma Homo sapiens 14-23 26363509-11 2016 TNF-alpha and IFN-gamma also enhanced the levels of PE(40:6) and decreased the levels of PE(O-38:6). phosphatidylethanolamine 89-91 interferon gamma Homo sapiens 14-23 26777439-0 2016 Leukocyte production of IFN-gamma and TNF-alpha in 8- to 12-y-old children with low serum iron levels. Iron 90-94 interferon gamma Homo sapiens 24-33 26921522-5 2016 The formulated LZnP nano-vaccine with the size of 30nm and outer leaflet lipid exhibited antitumor immunity as the secretion of cytokines in vitro and increased CD8(+) T cell response from IFN-gamma ELISPOT analysis ex vivo. lznp 15-19 interferon gamma Homo sapiens 189-198 26777439-9 2016 Decreased serum IFN-gamma concentrations and decreased in vitro production of IFN-gamma by PBMCs were found in the LSI group. lsi 115-118 interferon gamma Homo sapiens 16-25 26777439-9 2016 Decreased serum IFN-gamma concentrations and decreased in vitro production of IFN-gamma by PBMCs were found in the LSI group. lsi 115-118 interferon gamma Homo sapiens 78-87 26268146-5 2016 The in vitro literature on antidepressants shows that some antidepressants, such as clomipramine and fluoxetine, more consistently decrease pro-inflammatory cytokines (interleukin (IL)-6, interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha), whilst others (mirtazapine and venlafaxine) tend to increase their levels. Clomipramine 84-96 interferon gamma Homo sapiens 188-210 26268146-5 2016 The in vitro literature on antidepressants shows that some antidepressants, such as clomipramine and fluoxetine, more consistently decrease pro-inflammatory cytokines (interleukin (IL)-6, interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha), whilst others (mirtazapine and venlafaxine) tend to increase their levels. Fluoxetine 101-111 interferon gamma Homo sapiens 188-210 27124582-8 2016 In Jurkat T cells, Con A-induced mRNA levels of IL-2, IFN-gamma and TNF-alpha were downregulated by pretreatment of Gpx inhibitor, mercaptosuccinic acid. 2-thiomalic acid 131-152 interferon gamma Homo sapiens 54-63 26974691-7 2016 Isorhamnetin inhibited IFN-gamma-mediated stimulation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase and showed high-affinity binding to these kinases (binding constants: 4.46 x 10(6) M(-1) and 7.6 x 10(6) M(-1), respectively). 3-methylquercetin 0-12 interferon gamma Homo sapiens 23-32 25846071-10 2016 The number of IFN-gamma secretion cells and the ratio of IFN-gamma/IL-4 secretion cells were increased in the BB536 supplementation group at 7 months. bb536 110-115 interferon gamma Homo sapiens 14-23 25846071-10 2016 The number of IFN-gamma secretion cells and the ratio of IFN-gamma/IL-4 secretion cells were increased in the BB536 supplementation group at 7 months. bb536 110-115 interferon gamma Homo sapiens 57-66 26883061-6 2016 In activated CD4(+) T cells re-stimulated through CD3 and ICOS, IC87114 inhibited Akt and Erk activation, and the secretion of IL-2, IL-4, IL-17A, and IFN-gamma better than A66. IC 87114 64-71 interferon gamma Homo sapiens 151-160 26883061-8 2016 In vivo, therapeutic administration of ETP-46321 significantly inhibited responses to protein antigen as well as collagen-induced arthritis, as measured by antigen-specific antibody responses, secretion of IL-10, IL-17A or IFN-gamma, or clinical symptoms. ETP-46321 39-48 interferon gamma Homo sapiens 223-232 26858253-6 2016 In contrast, IFNgamma increased pro-apoptotic TXNIP post-transcriptionally via induction of endoplasmic reticulum stress, activation of inositol-requiring enzyme 1alpha (IRE1alpha), and suppression of miR-17, a microRNA that targets and down-regulates TXNIP. Inositol 136-144 interferon gamma Homo sapiens 13-21 27082871-9 2016 After stimulation with phorbol-12-myristate 13-acetate and ionomycin, the proportion of T cells producing interferon-gamma or interleukin-2 was higher in the low-IC-TAC group than in the high-IC-TAC group. Tetradecanoylphorbol Acetate 23-54 interferon gamma Homo sapiens 106-122 26962231-0 2016 alpha-NAC-Specific Autoreactive CD8+ T Cells in Atopic Dermatitis Are of an Effector Memory Type and Secrete IL-4 and IFN-gamma. alpha-nac 0-9 interferon gamma Homo sapiens 118-127 27082871-9 2016 After stimulation with phorbol-12-myristate 13-acetate and ionomycin, the proportion of T cells producing interferon-gamma or interleukin-2 was higher in the low-IC-TAC group than in the high-IC-TAC group. Ionomycin 59-68 interferon gamma Homo sapiens 106-122 27073858-15 2016 Ibuprofen modulated the immune response as measured by narrowed range of observed Il-13, Il-17 and IFN-gamma gene expression in mediastinal lymph nodes. Ibuprofen 0-9 interferon gamma Homo sapiens 99-108 27070591-0 2016 Inhibition of IFN-gamma-Induced Nitric Oxide Dependent Antimycobacterial Activity by miR-155 and C/EBPbeta. Nitric Oxide 32-44 interferon gamma Homo sapiens 14-23 27054340-11 2016 In addition, the proliferation of CTLs and the secretion of IFN-gamma also decreased in the dexmedetomidine group, compared with the control group (P<0.05). Dexmedetomidine 92-107 interferon gamma Homo sapiens 60-69 26913590-4 2016 Interferon-gamma (IFN-gamma) and platelet-derived growth factor-AA (PDGF-AA) are recombinantly produced and tagged with an N-terminal biotin. Biotin 134-140 interferon gamma Homo sapiens 0-16 26913590-4 2016 Interferon-gamma (IFN-gamma) and platelet-derived growth factor-AA (PDGF-AA) are recombinantly produced and tagged with an N-terminal biotin. Biotin 134-140 interferon gamma Homo sapiens 18-27 26683421-0 2016 Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-gamma production in CD8(+) lymphocytes. Fingolimod Hydrochloride 0-10 interferon gamma Homo sapiens 87-96 27342495-5 2016 RESULTS: The levels of IL-12 and IFN-gamma in the untreated AL group, ALL and ANLL groups were lower significantly than those in the control group (P<0.05), there was no significant difference between untreated AL and ANLL groups (P>0.05). Aluminum 60-62 interferon gamma Homo sapiens 33-42 27342495-6 2016 The levels of IL-12 and IFN-gamma in CR patients of AL group after treatment obviously higher than that of patients before treatment (P<0.05), but there was no significant difference as campared with that in control. Aluminum 52-54 interferon gamma Homo sapiens 24-33 27342495-7 2016 The levels of IL-12 and IFN-gamma in NR patients of AL group after treatment were obviously lower than that in control group (P<0.05), but there was no significant difference in comparision with patients before treatment (P>0.05). Aluminum 52-54 interferon gamma Homo sapiens 24-33 27342495-8 2016 The levels of IL-12 and IFN-gamma of AL-CR and AL-NR patients before treatment were not significant difference before treatment (P>0.05). Al-Cr 37-42 interferon gamma Homo sapiens 24-33 27342495-8 2016 The levels of IL-12 and IFN-gamma of AL-CR and AL-NR patients before treatment were not significant difference before treatment (P>0.05). Aluminum 37-39 interferon gamma Homo sapiens 24-33 27342495-9 2016 The levels of IL-12 and IFN-gamma of AL-CR patients obviously higher than that in AL-NR patients (P<0.05). Al-Cr 37-42 interferon gamma Homo sapiens 24-33 27342495-9 2016 The levels of IL-12 and IFN-gamma of AL-CR patients obviously higher than that in AL-NR patients (P<0.05). Aluminum 37-39 interferon gamma Homo sapiens 24-33 27342495-13 2016 CONCLUSION: The serum levels of both IL-12 and IFN-gamma are lower, but the changes of both serum levels may be helpful to diagnose and treatment of AL patients. Aluminum 149-151 interferon gamma Homo sapiens 47-56 26689752-5 2016 The immunoreactivity of Gr-1, F4/80, IFN-gamma, and phosphorylated STAT(signal transducer and activator of transcription)1 in corneal stroma was diminished significantly in the tofacitinib group. tofacitinib 177-188 interferon gamma Homo sapiens 37-46 26689752-7 2016 In in vitro study, human fibroblast pretreated by IFN-gamma showed phosphorylation of STAT1, and this phosphorylation was down-regulated by adding tofacitinib to the culture medium. tofacitinib 147-158 interferon gamma Homo sapiens 50-59 27252810-9 2016 RESULTS: Propranolol significantly decreased the T helper type 1 cytokine profile [Interleukin-2 (IL-2) and Interferon- gamma (IFN-gamma)] production in PHA stimulated Molt-4 and Jurkat cells, after 48 hour of incubation time, dose-dependently compared to untreated control cells. Propranolol 9-20 interferon gamma Homo sapiens 108-125 27252810-9 2016 RESULTS: Propranolol significantly decreased the T helper type 1 cytokine profile [Interleukin-2 (IL-2) and Interferon- gamma (IFN-gamma)] production in PHA stimulated Molt-4 and Jurkat cells, after 48 hour of incubation time, dose-dependently compared to untreated control cells. Propranolol 9-20 interferon gamma Homo sapiens 127-136 27252810-10 2016 CONCLUSION: Our data showed a dose dependent inhibitory effect of propranolol on the IL-2 and IFN-gamma production in human leukemic Molt-4 and Jurkat cells. Propranolol 66-77 interferon gamma Homo sapiens 94-103 27252810-11 2016 The anti- inflammatory effect of propranolol reported by other investigators may be in part due to its suppressive effect on production of inflammatory cytokines such as IL-2 and IFN-gamma. Propranolol 33-44 interferon gamma Homo sapiens 179-188 26939769-4 2016 Incubation of activated human T lymphocytes with gingerols increased the intracellular Ca(2+) concentration as well as the IFN-gamma secretion by about 20-30%. gingerol 49-58 interferon gamma Homo sapiens 123-132 26817996-2 2016 Unexpectedly, we observed that the critical soluble mediators of type-1 immune effector cells, IFNgamma and TNFalpha, synergize in the induction of cyclooxygenase 2 (COX2), the key enzyme in prostaglandin (PG)E2 synthesis, and the subsequent hyperactivation of myeloid-derived suppressor cells (MDSC) within the tumor microenvironment (TME) of ovarian cancer patients. Dinoprostone 191-211 interferon gamma Homo sapiens 95-103 27073674-8 2016 PBLs cultured in a glucose-free medium contained a significantly higher percentage of IL-4-positive and a lower percentage of IFN-gamma-positive CD4(+) T cells compared with those cultured in a high-glucose medium. Glucose 19-26 interferon gamma Homo sapiens 126-135 27097956-7 2016 Correlation analysis revealed that serum IFN-gamma level was significantly positively correlated with TG concentration in CHD patients (r = 0.560, p < 0.05), while the IL-10 level was negatively correlated with TG concentration (r = -0.411, p < 0.05). Triglycerides 102-104 interferon gamma Homo sapiens 41-50 26938947-8 2016 EBViNT infusion induced 2 waves of interferon-gamma response: 1 approximately 1 week and the other 4-8 weeks after the treatment. ebvint 0-6 interferon gamma Homo sapiens 35-51 26939769-5 2016 This gingerol-induced increase of IFN-gamma secretion could be blocked by the specific TRPV1 antagonist SB-366791. gingerol 5-13 interferon gamma Homo sapiens 34-43 26939769-5 2016 This gingerol-induced increase of IFN-gamma secretion could be blocked by the specific TRPV1 antagonist SB-366791. N-(3-methoxyphenyl)-4-chlorocinnamanilide 104-113 interferon gamma Homo sapiens 34-43 26939769-6 2016 The results of the present study point to an interaction of gingerols with TRPV1 in activated T lymphocytes leading to an augmentation of IFN-gamma secretion. gingerol 60-69 interferon gamma Homo sapiens 138-147 27007115-4 2016 Human NK cells treated with ionomycin lose their ability to degranulate and secrete IFN-gamma in response to a variety of stimuli, but IL-2 stimulation can compensate these defects. Ionomycin 28-37 interferon gamma Homo sapiens 84-93 26611774-8 2016 In contrast, TB-IRIS patients had significantly greater early increases in the frequency of tuberculosis-specific polyfunctional IFN-gamma(+)/IL-2(+)/TNF-alpha(+) CD4(+) T-cells on ART (P = .02); each quartile increase in the percentage of these cells was independently associated with a 2.8-fold increased risk of TB-IRIS (95% confidence interval, 1.1 to 7.5-fold). Terbium 13-15 interferon gamma Homo sapiens 129-138 26823467-5 2016 Duox2 suppression by siRNA led to an increase in ATP release in control cells and restoration of ATP release in cells treated with IFN-gamma. Adenosine Triphosphate 97-100 interferon gamma Homo sapiens 131-140 26823467-11 2016 This led to a 2-fold increase in ATP release in cells treated with IFN-gamma that was also inhibited by probenecid. Adenosine Triphosphate 33-36 interferon gamma Homo sapiens 67-76 26823467-11 2016 This led to a 2-fold increase in ATP release in cells treated with IFN-gamma that was also inhibited by probenecid. Probenecid 104-114 interferon gamma Homo sapiens 67-76 26823467-14 2016 Therefore, airway epithelial cells release less ATP in response to hypotonic stress in an inflammatory environment (IFN-gamma exposure). Adenosine Triphosphate 48-51 interferon gamma Homo sapiens 116-125 26823467-3 2016 Exposure of primary human airway epithelial cell cultures to IFN-gamma for 48 h did not alter Panx1 protein expression but significantly decreased ATP release in response to hypotonic stress. Adenosine Triphosphate 147-150 interferon gamma Homo sapiens 61-70 26744473-0 2016 Interferon-gamma is increased in the gut of patients with irritable bowel syndrome and modulates serotonin metabolism. Serotonin 97-106 interferon gamma Homo sapiens 0-16 26744473-13 2016 These results suggest that IFN-gamma downregulates SERT expression, hence likely playing a role in altered serotonin metabolism of patients with IBS. Serotonin 107-116 interferon gamma Homo sapiens 27-36 26959228-0 2016 Hierarchy Low CD4+/CD8+ T-Cell Counts and IFN-gamma Responses in HIV-1+ Individuals Correlate with Active TB and/or M.tb Co-Infection. Terbium 106-108 interferon gamma Homo sapiens 42-51 26965318-0 2016 Elevated on-treatment levels of serum IFN-gamma is associated with treatment failure of peginterferon plus ribavirin therapy for chronic hepatitis C. Chronic hepatitis C virus (HCV) infection had been associated with cytokine imbalance. Ribavirin 107-116 interferon gamma Homo sapiens 38-47 26965318-5 2016 Serial dynamic cytokine expression demonstrated that not only elevated IFN-gamma concentrations at specific time points but also the total IFN-gamma amount was strongly linked to non-response in peginterferon/ribavirin therapy. Ribavirin 209-218 interferon gamma Homo sapiens 71-80 26965318-5 2016 Serial dynamic cytokine expression demonstrated that not only elevated IFN-gamma concentrations at specific time points but also the total IFN-gamma amount was strongly linked to non-response in peginterferon/ribavirin therapy. Ribavirin 209-218 interferon gamma Homo sapiens 139-148 26959228-8 2016 Immunologically, HIV-1+ATB group showed significantly lower numbers of ESAT-6-/CFP-10-specific IFN-gamma+ T cells than HIV-1+LTB group. 4-anisyltetrazolium blue 23-26 interferon gamma Homo sapiens 95-104 26959228-9 2016 Consistently, PPD-specific IFN-gamma+CD4+/CD8+ T effector cells in HIV-1+ATB group were significantly lower than those in HIV-1+LTB group (P<0.001). 4-anisyltetrazolium blue 73-76 interferon gamma Homo sapiens 27-36 26973651-11 2016 IFN-gamma-treated macrophages become less sensitive to the regulatory effects of adenosine, allowing them to sustain macrophage activation for the duration of an adaptive immune response. Adenosine 81-90 interferon gamma Homo sapiens 0-9 26658215-10 2016 CONCLUSIONS: In the sigmoid colon of patients with LC, the key effector cytokines TNFalpha, IFNgamma, and IL-15 inhibited gamma-ENaC upregulation in response to aldosterone through a MEK1/2-mediated pathway. Aldosterone 161-172 interferon gamma Homo sapiens 92-100 26826241-11 2016 Suppression of IFN-gamma production was reversed by l-arginine supplementation, consistent with increased MDSC arginase-1 activity. Arginine 52-62 interferon gamma Homo sapiens 15-24 26628252-11 2016 A high level of agreement between the LOCI IFN-gamma method and T-SPOT.TB assay was observed in clinical studies that showed the LOCI IFN-gamma method could determine LTBI. Terbium 71-73 interferon gamma Homo sapiens 43-52 26628252-11 2016 A high level of agreement between the LOCI IFN-gamma method and T-SPOT.TB assay was observed in clinical studies that showed the LOCI IFN-gamma method could determine LTBI. Terbium 71-73 interferon gamma Homo sapiens 134-143 26714752-0 2016 Ginsenoside Rg5:Rk1 attenuates TNF-alpha/IFN-gamma-induced production of thymus- and activation-regulated chemokine (TARC/CCL17) and LPS-induced NO production via downregulation of NF-kappaB/p38 MAPK/STAT1 signaling in human keratinocytes and macrophages. Ginsenosides 0-11 interferon gamma Homo sapiens 41-50 26819204-5 2016 Fibroblasts treated with ZOL activate Vgamma9Vdelta2 T cells to produce IFN-gamma but not TNF. Zoledronic Acid 25-28 interferon gamma Homo sapiens 72-81 26678511-7 2016 In previous VAS recipients, VAS was associated with increased IFN-gamma responses to phytohaemagglutinin in females (geometric mean ratio (GMR): 3 97; 95% CI 1 44, 10 90) but not in males (GMR 0 44; 95% CI 0 14, 1 42); the opposite was observed in previously unsupplemented children. vas 28-31 interferon gamma Homo sapiens 62-71 26862702-5 2016 The re-differentiated iNKT cells showed proliferation and IFN-gamma production in response to alpha-galactosylceramide, induced dendritic cell maturation and downstream activation of both cytotoxic T lymphocytes and NK cells, and exhibited NKG2D- and DNAM-1-mediated NK cell-like cytotoxicity against cancer cell lines. alpha-galactosylceramide 94-118 interferon gamma Homo sapiens 58-67 26901772-12 2016 Finally, ChIP and Re-ChIP assays revealed that symmetrical dimethylarginine-containing proteins complexed with the CXCL11 promoter were diminished in p65 Arg174Lys-reconstituted EC stimulated with TNF and IFN-gamma. dimethylarginine 59-75 interferon gamma Homo sapiens 205-214 26893636-6 2016 TAES administration increased the percentage of Th1 and Th17 cells, the protein expression levels of interleukin (IL)-2 and interferon-gamma, the mRNA expression levels of T-bet and RAR-related orphan receptor-gammat, and decreased the percentage of Th2 cells, IL-10 protein expression levels, and GATA binding protein 3 mRNA expression levels. taes 0-4 interferon gamma Homo sapiens 124-140 26909479-1 2016 OBJECTIVE: The objective of the present study was to investigate the effect of vitamin A supplementation on serum Th17 (IL-6, IL-17, IFNgamma) and Treg (TGF-beta, IL-10) related cytokines in obese and non-obese women. Vitamin A 79-88 interferon gamma Homo sapiens 133-141 26787888-6 2016 Specifically, production of IFN-gamma on stimulation of dectin-1, mannose, and Toll-like receptors with Candida albicans and Staphylococcus epidermidis was 2.5- and 2.9-fold higher in high-risk subjects than in low-risk subjects, respectively (P = 0.007 and P = 0.01). Mannose 66-73 interferon gamma Homo sapiens 28-37 26501345-1 2016 PURPOSE: To examine the effect of post-resistance exercise alcohol ingestion on lipopolysaccharide (LPS)-stimulated production of IFNgamma, TNF-alpha, IL-1beta, IL-6, IL-8, and IL-10. Alcohols 59-66 interferon gamma Homo sapiens 130-138 26735612-4 2016 Furthermore, melatonin enhances splenic interleukin (IL)-10 expression in regulatory T cells by inducing IL-27 expression in the splenic DC; it also suppresses the expression of IFN-gamma, IL-17, IL-6, and CCL20 in the CNS and inhibits antigen-specific T cell proliferation. Melatonin 13-22 interferon gamma Homo sapiens 178-187 26639355-5 2016 Treatment of autologous Hsp70 induces higher expression of CD80 and CD86 on TAMs, as a result, increases B7/CD28 interaction, which in turns activates T cells and induces higher production of IL-2 and IFN-gamma, thereby increasing antigen-specific T cell proliferation. Tamoxifen 76-80 interferon gamma Homo sapiens 201-210 26709075-7 2016 Additionally, the effect of a stable analog of prostacyclin (carbaprostacyclin) on IL-4, IFN-gamma and TNF-alpha production by isolated spleen lymphocytes in response to Con A was analyzed. carboprostacyclin 61-78 interferon gamma Homo sapiens 89-98 26709219-4 2016 However, in contrast to mitoxantrone, BBR3378 inhibited the production of the proinflammatory cytokine IFN-gamma both in recently activated T cell blasts and established Th1 effectors, while sparing the activities of IL-13-producing Th2 cells. BBR3378 38-45 interferon gamma Homo sapiens 103-112 26709219-6 2016 In addition to IFN-gamma, in vitro and in vivo exposure to BBR3378 suppressed the expression of other T-bet regulated proteins, including CXCR3 and IL-2Rbeta. BBR3378 59-66 interferon gamma Homo sapiens 15-24 26315505-8 2016 Furthermore, an immunofluorescence staining assay showed that more MG63 cells were OPN-positive, while an Alizarin red staining indicated the increased formation of calcium nodules in the IFN-gamma and TNF-alpha combined pretreatment group. alizarin 106-118 interferon gamma Homo sapiens 188-197 26315505-8 2016 Furthermore, an immunofluorescence staining assay showed that more MG63 cells were OPN-positive, while an Alizarin red staining indicated the increased formation of calcium nodules in the IFN-gamma and TNF-alpha combined pretreatment group. Calcium 165-172 interferon gamma Homo sapiens 188-197 26615805-6 2016 Administration of HSA/M2e with Freund"s adjuvant resulted in a higher number of IFN-gamma-producing cells compared to HSA/M2e or M2e peptide emulsified in Freund"s adjuvant. freund"s 31-39 interferon gamma Homo sapiens 80-89 26927386-11 2016 CONCLUSION: During chronic HBV infection, IFN-gamma and IL-4 expressed by peripheral blood T cells play dual immunoregulatory roles, which are correlated with the efficacy of entecavir. entecavir 175-184 interferon gamma Homo sapiens 42-51 26553025-10 2016 However, a trend toward decreased IL-6, IL-8, and IFN-gamma levels, and favorable clinical outcomes were present in the macrolide group. Macrolides 120-129 interferon gamma Homo sapiens 50-59 26907385-10 2016 The dMPhis at term differentiated into dendritic (DC)-like cells, stimulating T cell activation, proliferation, and differentiation into IFN-gamma-producing T cellsdecidual CONCLUSIONS: The present study suggests that the differences in phenotypes and cytokine production between Mid- and Term-dMPhis relate to their different roles in the homeostasis of the maternal-fetal interface. dmphis 4-10 interferon gamma Homo sapiens 137-146 26933666-1 2016 Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores of 23.5 vs 46.3), more rapid resolution of clinical disease (20 hours earlier), reduced viral shedding (total median tissue culture infectious dose [TCID50] 7.4 vs 9.7), and significantly reduced expression of several inflammatory cytokines (interferon-gamma, tumor necrosis factor-alpha, interleukin-6, and others). Oseltamivir 40-51 interferon gamma Homo sapiens 465-510 26820885-8 2016 VSMCs in the neointima showed an increased expression of phospho-histone, synthetic and contractile SMC markers, IFN-gamma and phosphorylated STAT-3. vsmcs 0-5 interferon gamma Homo sapiens 113-122 26731100-6 2016 Unexpectedly, type I IFNs preferentially regulate IFN-gamma signaling in Ly6Clo rather than inflammatory Ly6Chi mononuclear cell populations. ly6clo 73-79 interferon gamma Homo sapiens 50-59 26699475-4 2016 We show that chronic activation with either bacterial lipopolysaccharide through Toll-like receptor 4 (TLR4) or leukocyte cytokine IFN-gamma induces reactive phenotypes in microglia associated with morphological changes, population expansion, CD11b and CD68 up-regulation, and proinflammatory cytokine (IL-1beta, TNF-alpha, IL-6) and nitric oxide (NO) release. Nitric Oxide 334-346 interferon gamma Homo sapiens 131-140 27774460-5 2016 Our results showed both increased frequency and activation (indicated by higher expression of ICOS, PD-1, HLA-DR, and Ki-67 and increased production of IL-21, IL-17, and IFN-gamma) of cTfh cells in psoriasis patients. ctfh 184-188 interferon gamma Homo sapiens 170-179 26727128-4 2016 Daunorubicin- or rebeccamycin-induced enhancement of the TJ barrier function partly rescued attenuation of the barrier function by the inflammatory cytokines TNF-alpha and IFN-gamma. Daunorubicin 0-12 interferon gamma Homo sapiens 172-181 26727128-4 2016 Daunorubicin- or rebeccamycin-induced enhancement of the TJ barrier function partly rescued attenuation of the barrier function by the inflammatory cytokines TNF-alpha and IFN-gamma. rebeccamycin 17-29 interferon gamma Homo sapiens 172-181 26524378-1 2016 A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Tryptophan 90-100 interferon gamma Homo sapiens 184-200 26524378-1 2016 A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Tryptophan 90-100 interferon gamma Homo sapiens 202-211 26524378-1 2016 A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Tryptophan 102-105 interferon gamma Homo sapiens 184-200 26524378-1 2016 A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Tryptophan 102-105 interferon gamma Homo sapiens 202-211 26524378-1 2016 A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Kynurenine 130-140 interferon gamma Homo sapiens 184-200 26524378-1 2016 A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Kynurenine 130-140 interferon gamma Homo sapiens 202-211 26706018-2 2016 OBJECTIVE: To compare the interferon-gamma-release assay (IGRA - QuantiFERON( ) TB Gold In-Tube) with the tuberculin skin test (TST - PPD-Rt 23) for latent tuberculosis infection (LTBI) in patients with HIV. tb gold 80-87 interferon gamma Homo sapiens 26-42 27093468-8 2016 There was significant (P < 0.0001) association between IFN-gamma levels and the fibrosis stages and activity, albumin, platelet count, total bilirubin, and international normalized ratio (INR). Bilirubin 144-153 interferon gamma Homo sapiens 58-67 26987337-7 2016 The interferon gamma (IFNgamma) was increased by about eightfold, but only in the medium of THP1 cells grown with CS. Cesium 114-116 interferon gamma Homo sapiens 4-31 27374284-0 2016 Interferon-gamma Attenuates 5-Hydroxytryptamine-Induced Melanogenesis in Primary Melanocyte. Serotonin 28-47 interferon gamma Homo sapiens 0-16 26546776-8 2016 IFN-gamma and IP-10 were positively associated with fasting glucose, whereas IL-1alpha, ICAM1 and adiponectin were inversely associated with insulin and insulin resistance. Glucose 60-67 interferon gamma Homo sapiens 0-9 27630735-8 2016 In vitro studies using TNF-alpha and IFN-gamma treated HaCaT cells revealed that VAL inhibited the exaggerated expression of Th2 chemokines including TARC/CCL17, MDC/CCL22, and proinflammatory chemokines such as CXCL8, GM-CSF, and I-CAM through blockade of the NF-kappaB pathway. valencene 81-84 interferon gamma Homo sapiens 37-46 27433370-3 2016 The urinary neopterin/creatinine ratio can quantify the systemic interferon-gamma effect in patients with M. tuberculosis infection. Neopterin 12-21 interferon gamma Homo sapiens 65-81 27433370-3 2016 The urinary neopterin/creatinine ratio can quantify the systemic interferon-gamma effect in patients with M. tuberculosis infection. Creatinine 22-32 interferon gamma Homo sapiens 65-81 25565016-0 2016 Vanadium pentoxide prevents NK-92MI cell proliferation and IFNgamma secretion through sustained JAK3 phosphorylation. vanadium pentoxide 0-18 interferon gamma Homo sapiens 59-67 28042583-3 2016 We have analyzed associations between IFN-gamma responses measured in QuantiFERON -TB Gold In-tube (QFT) assay, TB disease severity, and Mtb infection activity. tb gold 83-90 interferon gamma Homo sapiens 38-47 28042583-8 2016 The rate of positive QFT results and the levels of antigen-driven IFN-gamma secretion increased in a row: patients with residual TB lesions < patients with low TB activity < patients with high TB activity. Terbium 129-131 interferon gamma Homo sapiens 66-75 28042583-8 2016 The rate of positive QFT results and the levels of antigen-driven IFN-gamma secretion increased in a row: patients with residual TB lesions < patients with low TB activity < patients with high TB activity. Terbium 163-165 interferon gamma Homo sapiens 66-75 28042583-8 2016 The rate of positive QFT results and the levels of antigen-driven IFN-gamma secretion increased in a row: patients with residual TB lesions < patients with low TB activity < patients with high TB activity. Terbium 163-165 interferon gamma Homo sapiens 66-75 28042583-10 2016 The results suggest that quantitative parameters of IFN-gamma secretion play a minor role in determining the course of TB disease but mirror the activity of the infectious process. Terbium 119-121 interferon gamma Homo sapiens 52-61 28053993-9 2016 Low triglycerides were associated with upregulation of IFN-gamma and IL-12, suggesting activation of Th1 helper cells. Triglycerides 4-17 interferon gamma Homo sapiens 55-64 27294162-7 2016 The placental extravillous layer of the MGH showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN-gamma and low levels of IL-1beta and IL-8, whereas the placental villous layer contained high levels of IL-17 and IFN-gamma. mgh 40-43 interferon gamma Homo sapiens 96-105 27294162-7 2016 The placental extravillous layer of the MGH showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN-gamma and low levels of IL-1beta and IL-8, whereas the placental villous layer contained high levels of IL-17 and IFN-gamma. mgh 40-43 interferon gamma Homo sapiens 214-223 27137130-4 2016 The influence of IFN-gamma incorporated nanoemulsions on functional activity of mononuclear cell for Escherichia coli enteropathogenic was analyzed through superoxide release, phagocytosis, microbicidal activity and intracellular calcium release. Superoxides 156-166 interferon gamma Homo sapiens 17-26 26852856-1 2016 Alpha-galactosylceramide (GC) represents a potentially new class of adjuvant because GC strongly induces interferon (IFN) gamma production from natural killer T (NKT) cells, leading to the induction of strong antitumor immunity. alpha-galactosylceramide 0-24 interferon gamma Homo sapiens 105-127 26852856-1 2016 Alpha-galactosylceramide (GC) represents a potentially new class of adjuvant because GC strongly induces interferon (IFN) gamma production from natural killer T (NKT) cells, leading to the induction of strong antitumor immunity. alpha-galactosylceramide 26-28 interferon gamma Homo sapiens 105-127 26129651-7 2016 Carbachol prevented IFN-gamma-mediated increase in [Ca(2+)](i). Carbachol 0-9 interferon gamma Homo sapiens 20-29 26129651-9 2016 IFN-gamma blocked carbachol-induced high molecular weight glycoconjugate secretion and reduced goblet cell proliferation. Carbachol 18-27 interferon gamma Homo sapiens 0-9 26770205-12 2016 Furthermore, the DFSCs suppressed IL-4 and IFN-gamma cytokine levels and enhanced IL-10 levels compared with the other cell sources. dfscs 17-22 interferon gamma Homo sapiens 43-52 26770205-14 2016 These results suggest that IFN-gamma stimulates DFSCs by inducing an immunomodulatory effect on the PBMCs of healthy donors while suppressing apoptosis and proliferation and increasing the number of CD4(+)FoxP3(+) cells. dfscs 48-53 interferon gamma Homo sapiens 27-36 27137130-4 2016 The influence of IFN-gamma incorporated nanoemulsions on functional activity of mononuclear cell for Escherichia coli enteropathogenic was analyzed through superoxide release, phagocytosis, microbicidal activity and intracellular calcium release. Calcium 230-237 interferon gamma Homo sapiens 17-26 27238907-0 2016 Cost effectiveness of interferon-gamma release assay for tuberculosis screening using three months of rifapentine and isoniazid among long-term expatriates from low to high incidence countries. Isoniazid 118-127 interferon gamma Homo sapiens 22-38 26719671-6 2015 Transmission electron microscopy images showed that the C225-IFNG-IMANS were successfully prepared, and the ability of the nanospheres to target GLC-82 cells in vitro was confirmed by Prussian blue staining, immunofluorescence experiments, and magnetic resonance imaging. ferric ferrocyanide 184-197 interferon gamma Homo sapiens 56-65 26631832-7 2016 After six months (M6) of anti-TB treatment (ATT) in HIV(-)TB(+) patients, IFN-gamma, IL-10, and MIP-1alpha levels normalized. Terbium 30-32 interferon gamma Homo sapiens 74-83 26494122-5 2015 Rather, bortezomib activated NF-kappaB p65 in CD8(+) T cells, stabilizing expression of T-cell receptor CD3zeta and IL2 receptor-alpha, while maintaining IFNgamma secretion to improve FasL-mediated tumor lysis. Bortezomib 8-18 interferon gamma Homo sapiens 154-162 26786651-1 2016 BACKGROUND: The recently introduced IFN-gamma release assay (IGRA) has been reported to improve the diagnosis of TB. Terbium 113-115 interferon gamma Homo sapiens 36-45 26719671-7 2015 Transfection photographs and agarose gel electrophoresis proved that pDONR223-IFNG could be encased in the albumin nanospheres. Sepharose 29-36 interferon gamma Homo sapiens 78-82 26655409-0 2015 Ethanol extracts of Sanguisorba officinalis L. suppress TNF-alpha/IFN-gamma-induced pro-inflammatory chemokine production in HaCaT cells. Ethanol 0-7 interferon gamma Homo sapiens 66-75 26458804-3 2015 Preclinical studies demonstrate that formulations containing tetravalent DEN-80E adjuvanted with ISCOMATRIX adjuvant induce high titer virus neutralizing antibodies and IFN-gamma producing T cells in flavivirus-naive non-human primates. den-80e 73-80 interferon gamma Homo sapiens 170-179 26458804-3 2015 Preclinical studies demonstrate that formulations containing tetravalent DEN-80E adjuvanted with ISCOMATRIX adjuvant induce high titer virus neutralizing antibodies and IFN-gamma producing T cells in flavivirus-naive non-human primates. iscomatrix adjuvant 97-117 interferon gamma Homo sapiens 170-179 26667768-6 2015 Positive correlations between the frequency of CD4+CD45RO+IL-17+IFN-gamma- T-cells and serum LDL-C (P=0.007), triglyceride (P=0.02), and systolic (P=0.001) and diastolic (P=0.009) blood pressures (BP) were found. Triglycerides 110-122 interferon gamma Homo sapiens 64-73 26793612-8 2015 CONCLUSION: Thymol and carvacrol could contribute to modulation of T cell activity by reducing IL-2 and IFN-gamma production possibly through down regulation of AP-1 and NFAT-2 transcription factors suggesting their potential usefulness for reduction of T cell overactivity in immune-mediated diseases. carvacrol 23-32 interferon gamma Homo sapiens 104-113 26667768-7 2015 The frequency of CD4+CD45RO+IL-17-IFN-gamma- T-cells, which was higher in controls than patients, showed negative correlations with the serum LDL-C (P=0.01) and triglyceride (P=0.02) levels and systolic (P=0.003) and diastolic (P=0.01) BPs. Triglycerides 161-173 interferon gamma Homo sapiens 34-43 26421484-8 2015 Chemically conjugating IFN-gamma to silk films through disulfide bonds allowed for longer-term release to 10 days. Disulfides 55-64 interferon gamma Homo sapiens 23-32 26307433-7 2015 IVIG also enhanced interferon-gamma production with IL-2, IL-12 and IL-18. ivig 0-4 interferon gamma Homo sapiens 19-35 26835425-0 2015 IFNgamma-Inducible Chemokines Decrease upon Selenomethionine Supplementation in Women with Euthyroid Autoimmune Thyroiditis: Comparison between Two Doses of Selenomethionine (80 or 160 mug) versus Placebo. Selenomethionine 44-60 interferon gamma Homo sapiens 0-8 26475400-3 2015 This in vitro study investigated the interference of BPA with interferon-gamma (IFN-gamma)-induced tryptophan breakdown and neopterin production in human peripheral blood mononuclear cells (PBMC). bisphenol A 53-56 interferon gamma Homo sapiens 62-89 26475400-3 2015 This in vitro study investigated the interference of BPA with interferon-gamma (IFN-gamma)-induced tryptophan breakdown and neopterin production in human peripheral blood mononuclear cells (PBMC). Tryptophan 99-109 interferon gamma Homo sapiens 62-89 26475400-4 2015 The pro-inflammatory cytokine IFN-gamma induces the conversion of the essential amino acid tryptophan into kynurenine via the enzyme indoleamine-2,3-dioxygenase (IDO-1). essential amino acid tryptophan 70-101 interferon gamma Homo sapiens 30-39 26475400-4 2015 The pro-inflammatory cytokine IFN-gamma induces the conversion of the essential amino acid tryptophan into kynurenine via the enzyme indoleamine-2,3-dioxygenase (IDO-1). Kynurenine 107-117 interferon gamma Homo sapiens 30-39 26475400-7 2015 Treatment of cells with BPA [12.5-200muM] resulted in a significant and dose-dependent suppression of mitogen-induced tryptophan breakdown and neopterin formation along with a decrease of IFN-gamma levels. bisphenol A 24-27 interferon gamma Homo sapiens 188-197 26359544-7 2015 As2S2 at 10muM inhibited production of IL-6, -10, -17A, tumor necrosis factor-alpha, and interferon-gamma from the activated peripheral blood mononuclear cells, though the effects were not statistically significant. Arsenic(II) sulfide 0-5 interferon gamma Homo sapiens 89-105 26507164-9 2015 Icariin treatment resulted in a reduced expression of p-P38 and p-ERK signal activation induced by TNF-alpha/IFN-gamma; however, only SB203580, the p38 alpha/beta inhibitor, inhibited the secretion of inflammatory cytokines induced by TNF-alpha/IFN-gamma in cultured HaCaT cells. icariin 0-7 interferon gamma Homo sapiens 109-118 26507164-9 2015 Icariin treatment resulted in a reduced expression of p-P38 and p-ERK signal activation induced by TNF-alpha/IFN-gamma; however, only SB203580, the p38 alpha/beta inhibitor, inhibited the secretion of inflammatory cytokines induced by TNF-alpha/IFN-gamma in cultured HaCaT cells. icariin 0-7 interferon gamma Homo sapiens 245-254 26507164-10 2015 The differential expression of TNF-alpha-R1 and IFN-gamma-R1 was also observed after the stimulation of TNF-alpha/IFN-gamma, which was significantly normalized after the icariin treatment. icariin 170-177 interferon gamma Homo sapiens 48-57 25925687-10 2015 Analyses showed that >16 HLA-DQ epitope mismatches and pretransplant, peripheral blood, donor-reactive IFN-gamma ELISPOT assay results correlated with development of DSAs and/or AR on tacrolimus withdrawal. Tacrolimus 187-197 interferon gamma Homo sapiens 106-115 26309093-2 2015 While the immunosuppressive effects are widely known, it has only been recently reported that pegylated recombinant human IL-10 (PEG-rHuIL-10) elicits potent interferon-gamma (IFN-gamma) and CD8 T-cell-dependent antitumor effects in murine tumor models. peg-rhuil-10 129-141 interferon gamma Homo sapiens 158-174 26309093-2 2015 While the immunosuppressive effects are widely known, it has only been recently reported that pegylated recombinant human IL-10 (PEG-rHuIL-10) elicits potent interferon-gamma (IFN-gamma) and CD8 T-cell-dependent antitumor effects in murine tumor models. peg-rhuil-10 129-141 interferon gamma Homo sapiens 176-185 26309093-4 2015 Also, in isolated CD8 T cells, PEG-rHuIL-10 potentiates prototypic Tc1 cytokine IFN-gamma expression and induces perforin and granzyme B secretion. peg-rhuil-10 31-43 interferon gamma Homo sapiens 80-89 29391997-6 2015 There was a positive correlation between IFN-gamma and vitamin D levels (p<0.05) in the study group, whereas IgE, IL-4, and IL-10 levels showed a negative correlation with vitamin D3 levels (p<0.05). Vitamin D 55-64 interferon gamma Homo sapiens 41-50 26372480-10 2015 RESULTS: Major histocompatibility complex class I-restricted CD8 clones proliferated and secreted IFNgamma following abacavir binding to surface and endogenous HLA-B57 : 01. abacavir 117-125 interferon gamma Homo sapiens 98-106 26494301-8 2015 Pre-treatment with EGCG reduced the level of IFN-gamma-induced priming signal via the down-regulation of pro-IL-1beta and pro-capspase-1 in HEKn cells. epigallocatechin gallate 19-23 interferon gamma Homo sapiens 45-54 26494301-9 2015 Furthermore, treatment with EGCG attenuated poly(dA:dT)-induced ASC oligomerization and caspase-1 activation in IFN-gamma-primed HEKn cells. epigallocatechin gallate 28-32 interferon gamma Homo sapiens 112-121 26494301-9 2015 Furthermore, treatment with EGCG attenuated poly(dA:dT)-induced ASC oligomerization and caspase-1 activation in IFN-gamma-primed HEKn cells. poly 44-48 interferon gamma Homo sapiens 112-121 26494301-9 2015 Furthermore, treatment with EGCG attenuated poly(dA:dT)-induced ASC oligomerization and caspase-1 activation in IFN-gamma-primed HEKn cells. amsonic acid 49-51 interferon gamma Homo sapiens 112-121 26494301-9 2015 Furthermore, treatment with EGCG attenuated poly(dA:dT)-induced ASC oligomerization and caspase-1 activation in IFN-gamma-primed HEKn cells. Thymidine 52-54 interferon gamma Homo sapiens 112-121 26494301-10 2015 These results suggest that EGCG attenuates AIM2-induced IL-1beta secretion by suppressing both IFN-gamma-mediated priming and poly(dA:dT)-induced ASC oligomerization of inflammasomes in human epidermal keratinocytes. epigallocatechin gallate 27-31 interferon gamma Homo sapiens 95-104 26460269-0 2015 An electrochemical aptasensor for detection of IFN-gamma using graphene and a dual signal amplification strategy based on the exonuclease-mediated surface-initiated enzymatic polymerization. Graphite 63-71 interferon gamma Homo sapiens 47-56 26460269-9 2015 As a result, the electron mediator hexaammineruthenium(III) chloride ([Ru(NH3)6](3+)) electrostatically adsorbed onto DNA producing a strong electrochemical signal which can be used to quantitatively measure the IFN-gamma levels. hexaammineruthenium(iii) chloride 35-68 interferon gamma Homo sapiens 212-221 26460269-9 2015 As a result, the electron mediator hexaammineruthenium(III) chloride ([Ru(NH3)6](3+)) electrostatically adsorbed onto DNA producing a strong electrochemical signal which can be used to quantitatively measure the IFN-gamma levels. RUTHENIUM (III) HEXAAMINE ION 70-84 interferon gamma Homo sapiens 212-221 26452032-7 2015 In comparison with IFN alpha or beta, IFN gamma treatment remarkably augmented apoptosis in PC-3 cells induced with polyinosinic:polycytidylic acid (poly I:C), a synthesized form of dsRNA. Poly I-C 116-147 interferon gamma Homo sapiens 38-47 26452032-7 2015 In comparison with IFN alpha or beta, IFN gamma treatment remarkably augmented apoptosis in PC-3 cells induced with polyinosinic:polycytidylic acid (poly I:C), a synthesized form of dsRNA. Poly I-C 149-157 interferon gamma Homo sapiens 38-47 26835425-11 2015 However, we observed a Semet-dependent downregulation of the IFNgamma-inducible chemokines, especially CXCL-9 and -10, which may serve as helpful biomarkers in future selenium supplementation trials. Selenium 167-175 interferon gamma Homo sapiens 61-69 25971794-6 2015 Our study demonstrated that, compared with model group, paeoniflorin inhibited ovalbumin (OVA)-induced increases in Raw and eosinophil count; interleukin (IL)-4, IgE levels were recovered in bronchoalveolar lavage fluid compared; increased IFN-gamma level in bronchoalveolar lavage fluid; histological studies demonstrated that paeoniflorin substantially inhibited OVA-induced eosinophilia in lung tissue and lung tissue compared with model group. peoniflorin 56-68 interferon gamma Homo sapiens 240-249 26507164-0 2015 Icariin inhibits TNF-alpha/IFN-gamma induced inflammatory response via inhibition of the substance P and p38-MAPK signaling pathway in human keratinocytes. icariin 0-7 interferon gamma Homo sapiens 27-36 26507164-3 2015 In this study, we evaluated the anti-inflammatory potential and mechanisms of icariin in the tumor necrosis factor-alpha (TNF-alpha)/interferon-gamma (IFN-gamma)-induced inflammatory response in human keratinocytes (HaCaT cells) by observing these cells in the presence or absence of icariin. icariin 78-85 interferon gamma Homo sapiens 133-160 26507164-8 2015 We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner. icariin 14-21 interferon gamma Homo sapiens 42-51 26507164-8 2015 We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner. icariin 146-153 interferon gamma Homo sapiens 42-51 26546878-9 2015 Spot-forming cell (SFC) counts in the IFN-gamma ELISPOT assay decreased from baseline after bortezomib (p=0.011) or thalidomide (p=0.096) treatment. Bortezomib 92-102 interferon gamma Homo sapiens 38-47 26546878-9 2015 Spot-forming cell (SFC) counts in the IFN-gamma ELISPOT assay decreased from baseline after bortezomib (p=0.011) or thalidomide (p=0.096) treatment. Thalidomide 116-127 interferon gamma Homo sapiens 38-47 26397740-8 2015 We also determined that autocrine IFN-gamma in MCF-7 increases mRNA expression of ERbeta resulting in enhanced sensitivity to tamoxifen (TAM). Tamoxifen 126-135 interferon gamma Homo sapiens 34-43 26397740-8 2015 We also determined that autocrine IFN-gamma in MCF-7 increases mRNA expression of ERbeta resulting in enhanced sensitivity to tamoxifen (TAM). Tamoxifen 137-140 interferon gamma Homo sapiens 34-43 26313134-9 2015 Importantly, interaction analyses revealed a specific interaction between IFNgamma genotype (rs1861494) and early life stress affecting amygdala reactivity to emotional faces, resulting from a positive association between CTQ scores and amygdala reactivity in C allele carriers while this association was absent in T homozygotes. cysteine tryptophylquinone 222-225 interferon gamma Homo sapiens 74-82 25794770-1 2015 INTRODUCTION: Recently diagnosis of latent tuberculosis infection (LTBI) can be made using the tuberculin skin test (TST) or by techniques known as interferon-gamma release assays (IGRAS), being QuantiFERON( )-TB Gold In-Tube (QF-G-IT) the most used. tb gold 210-217 interferon gamma Homo sapiens 148-164 26581714-9 2015 At 30 days, the lumbar spinal cords of glibenclamide-treated WT/EAE and Abcc8-/-/EAE mice showed significantly fewer invading immune cells, including leukocytes (CD45), T cells (CD3), B cells (CD20) and macrophages/microglia (CD11b), and fewer cells expressing pro-inflammatory cytokines (TNF-alpha, IFN-gamma, IL-17). Glyburide 39-52 interferon gamma Homo sapiens 300-309 26549640-3 2015 Inhibition of NADPH oxidases or knockdown of gp91phox in CD8(+) T cells abrogates ROS generation, which in turn modulates JNK and NFkappaB signalling with decreases in both IFNgamma levels and CD39 expression. Reactive Oxygen Species 82-85 interferon gamma Homo sapiens 173-181 26549640-4 2015 CD39(+)CD8(+) T cells substantially inhibit IFNgamma production by CD39(-)CD8(+) T cells via the paracrine generation of adenosine, which is operational via adenosine type 2A receptors. Adenosine 121-130 interferon gamma Homo sapiens 44-52 26549640-6 2015 Our findings provide insights into Tc1-mediated IFNgamma responses and ROS generation and link these pathways to CD39/adenosine-mediated effects in immunological disease. Adenosine 118-127 interferon gamma Homo sapiens 48-56 26485281-7 2015 High salt also impairs Treg function by inducing IFNgamma production in these cells. Salts 5-9 interferon gamma Homo sapiens 49-57 26835425-0 2015 IFNgamma-Inducible Chemokines Decrease upon Selenomethionine Supplementation in Women with Euthyroid Autoimmune Thyroiditis: Comparison between Two Doses of Selenomethionine (80 or 160 mug) versus Placebo. Selenomethionine 157-173 interferon gamma Homo sapiens 0-8 26250154-5 2015 RESULTS: The metabolite DHD, like its parent molecule dydrogesterone, suppresses the production of the pro-inflammatory cytokines IFN- gamma and TNF-alpha and upregulates the production of the anti-inflammatory cytokine IL-4. Dydrogesterone 54-68 interferon gamma Homo sapiens 130-140 26524592-5 2015 NaCl increased IFNgamma secretion in Tregs, and reducing IFNgamma - either by neutralization with anti-IFNgamma antibodies or shRNA-mediated knockdown - restored suppressive activity in Tregs. Sodium Chloride 0-4 interferon gamma Homo sapiens 15-23 26524592-7 2015 A high-salt diet also impaired human Treg function and was associated with the induction of IFNgamma-secreting Tregs in a xenogeneic graft-versus-host disease model and in adoptive transfer models of experimental colitis. Salts 7-11 interferon gamma Homo sapiens 92-100 26215374-4 2015 The effect of classical activators (lipopolysaccharide, LPS; interferon-gamma, IFN-gamma) was further potentiated with hypoxic (5% O2) conditions. Oxygen 131-133 interferon gamma Homo sapiens 61-77 26288256-2 2015 We have reported that interferon-gamma (IFN-gamma) enhances FcgammaR-dependent ROS production. Reactive Oxygen Species 79-82 interferon gamma Homo sapiens 22-38 26215374-4 2015 The effect of classical activators (lipopolysaccharide, LPS; interferon-gamma, IFN-gamma) was further potentiated with hypoxic (5% O2) conditions. Oxygen 131-133 interferon gamma Homo sapiens 79-88 26342289-8 2015 RESULTS: Markers of TLR-activation increased following AZD8848 administration (CXCL10, TNFalpha, IL-6, IFNgamma). AZD8848 55-62 interferon gamma Homo sapiens 103-111 26618646-10 2015 Interferon-gamma transcript number was inversely correlated with GCD (r = -0.37, P < 0.04) and TMH (r = -0.37, P = 0.02), and directly correlated with lissamine green staining (r = 0.51, P < 0.001) and SPRR-2G expression (r = 0.32, P < 0.05). tmh 98-101 interferon gamma Homo sapiens 0-16 26618646-10 2015 Interferon-gamma transcript number was inversely correlated with GCD (r = -0.37, P < 0.04) and TMH (r = -0.37, P = 0.02), and directly correlated with lissamine green staining (r = 0.51, P < 0.001) and SPRR-2G expression (r = 0.32, P < 0.05). Amaranth Dye 154-163 interferon gamma Homo sapiens 0-16 26339056-7 2015 In an electrophoretic mobility shift assay, tyrosine-phosphorylated STAT1 (pY-STAT1) with Y3 associated with the gamma-activated sequence, probably as high-molecular-weight complexes (HMWCs), which may account for partial inhibition of a reporter assay from IFN-gamma by Y3. Tyrosine 44-52 interferon gamma Homo sapiens 258-267 26339056-13 2015 Molecular modeling and experiments suggested that the two C proteins bind to and stabilize the parallel form of the STAT1 dimer, which are likely to be phosphorylated at Tyr(701), further inducing high-molecular-weight complex formation and inhibition of transcription by IFN-gamma. Tyrosine 170-173 interferon gamma Homo sapiens 272-281 26299324-10 2015 The level of interferon (IFN)-gamma in the serum at 48 h was significantly decreased following surgery in the control group, compared with the pre-surgical values (3.782 +- 0.282, vs. 4.089 +- 0.339 pg/ml, respectively) and the ratio of IFN-gamma to interleukin-4 was well preserved in the lidocaine group. Lidocaine 290-299 interferon gamma Homo sapiens 13-35 26385178-7 2015 Inhibiting ROS and SHP2 rescued cellular responses to IFN-gamma-induced cytotoxicity and inhibition of cell proliferation in PC14PE6/AS2 cells. ros 11-14 interferon gamma Homo sapiens 54-63 26497557-6 2015 Proliferating 5-aza exposed NK cells exhibited increased IFN-gamma production and degranulation towards tumor target cells. Azacitidine 14-19 interferon gamma Homo sapiens 57-66 26431276-2 2015 We observed that treatment with the proteasome inhibitor bortezomib in mice bearing various solid tumors resulted in an upregulated expression of various Notch signaling components in lymphoid tissues, thereby increasing CD8+T-lymphocyte IFNgamma secretion and expression of effector molecules, perforin and granzyme B, as well as the T-box transcription factor eomesodermin. Bortezomib 57-67 interferon gamma Homo sapiens 238-246 26500455-8 2015 Treatment with a combination of IL-6, LPS, TNF-alpha, IFN- gamma and IL-1beta induced the highest nitrite secretion (2.91 fold, P < 0.01) as compared to cells incubated in medium alone. Nitrites 98-105 interferon gamma Homo sapiens 54-64 26543364-14 2015 CONCLUSION: The MTX-LNC were better than the MTX solution at reducing proinflammatory cytokines and T-cell-derived cytokines such as interferon-gamma and interleukin-17A. Methotrexate 16-19 interferon gamma Homo sapiens 133-149 26431276-3 2015 Bortezomib also neutralized TGFbeta-mediated suppression of IFNgamma and granzyme B expression in activated CD8+T-cells. Bortezomib 0-10 interferon gamma Homo sapiens 60-68 26465323-7 2015 TBE vaccine responses were characterized by lower IFN-gamma responses and high proportions of TNF-alpha+IL-2+ cells. tbe 0-3 interferon gamma Homo sapiens 50-59 26472156-5 2015 Ex vivo, Gamma secretase inhibitor (GSI) (inhibitor of Notch receptor processing) significantly diminished the PGN+poly(I:C)-induced secretion of M1- and M2-associated cytokines in decidual macrophages, and of proinflammatory cytokines (IFN-gamma, TNF-alpha and IL-6) and chemokines (MIP-1beta) in decidual and placental cells. 2-(5-Chlorothiophen-2-Yl)-N-[(3s)-1-(4-{2-[(Dimethylamino)methyl]-1h-Imidazol-1-Yl}-2-Fluorophenyl)-2-Oxopyrrolidin-3-Yl]ethanesulfonamide 36-39 interferon gamma Homo sapiens 237-246 26355158-4 2015 IFN-gamma priming of macrophages selectively prevents the induction of the A2bR in macrophages to mitigate sensitivity to adenosine and to prevent this regulatory transition. Adenosine 122-131 interferon gamma Homo sapiens 0-9 26355158-8 2015 Thus, we propose a novel mechanism whereby IFN-gamma contributes to host defense by desensitizing macrophages to the immunoregulatory effects of adenosine. Adenosine 145-154 interferon gamma Homo sapiens 43-52 26200933-11 2015 The data also suggests that LAM-induced IFN-gamma and TNF-alpha could be used as biomarkers of protective immunity. lipoarabinomannan 28-31 interferon gamma Homo sapiens 40-49 26313265-7 2015 The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20. nac 41-44 interferon gamma Homo sapiens 161-177 26313265-7 2015 The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20. nac 41-44 interferon gamma Homo sapiens 179-187 26215444-5 2015 An enzyme-linked immunosorbent assay (ELISA) was used to measure IL-4 and IFN-gamma secretion upon alpha-galactosylceramide (alpha-GalCer) activation ex vivo. alpha-galactosylceramide 99-123 interferon gamma Homo sapiens 74-83 26215444-5 2015 An enzyme-linked immunosorbent assay (ELISA) was used to measure IL-4 and IFN-gamma secretion upon alpha-galactosylceramide (alpha-GalCer) activation ex vivo. Galactosylceramides 130-137 interferon gamma Homo sapiens 74-83 26249853-0 2015 Protective effect of hydrogen sulfide on TNF-alpha and IFN-gamma-induced injury of intestinal epithelial barrier function in Caco-2 monolayers. Hydrogen Sulfide 21-37 interferon gamma Homo sapiens 55-64 28455045-4 2015 MRPs also exhibited activity to quench RNS as assessed by nitric oxide (NO) inhibition in differentiated Caco-2 cells that were induced with interferon-gamma (IFN-gamma) and phorbol ester (PMA) cocktail. Radon 39-42 interferon gamma Homo sapiens 141-157 26249853-2 2015 In this study, the possible protective effect of H2S on TNF-alpha/IFN-gamma induced barrier dysfunction was investigated in Caco-2 cell monolayers. Hydrogen Sulfide 49-52 interferon gamma Homo sapiens 66-75 26249853-7 2015 RESULTS: NaHS at 500 uM significantly attenuated TNF-alpha/IFN-gamma-indueced Caco-2 monolayer barrier injury. sodium bisulfide 9-13 interferon gamma Homo sapiens 59-68 26249853-7 2015 RESULTS: NaHS at 500 uM significantly attenuated TNF-alpha/IFN-gamma-indueced Caco-2 monolayer barrier injury. caco-2 78-84 interferon gamma Homo sapiens 59-68 26249853-8 2015 The increased expression of MLCK and increased phosphorylation level of MLC induced by TNF-alpha/IFN-gamma was also inhibited significantly by NaHS. sodium bisulfide 143-147 interferon gamma Homo sapiens 97-106 26249853-9 2015 Additionally, NaHS inhibited TNF-alpha/IFN-gamma induced activation and nuclear translocation of NF-kB p65. sodium bisulfide 14-18 interferon gamma Homo sapiens 39-48 26249853-10 2015 CONCLUSION: The present study reveals the protective effect of H2S on TNF-alpha and IFN-gamma-induced injury of intestinal epithelial barrier function in Caco-2 monolayers and suggests that the suppression of MLCK-P-MLC signaling mediated by NF-kB P65 might be one of the mechanisms underlying the protective effect of H2S. Hydrogen Sulfide 63-66 interferon gamma Homo sapiens 84-93 26811721-8 2015 Moreover, rLPG3, CT, and NT fragments were markedly stimulated the secretion of IFN-gamma by NK cells (P<0.001). nt 25-27 interferon gamma Homo sapiens 80-89 26249853-10 2015 CONCLUSION: The present study reveals the protective effect of H2S on TNF-alpha and IFN-gamma-induced injury of intestinal epithelial barrier function in Caco-2 monolayers and suggests that the suppression of MLCK-P-MLC signaling mediated by NF-kB P65 might be one of the mechanisms underlying the protective effect of H2S. Hydrogen Sulfide 319-322 interferon gamma Homo sapiens 84-93 26275341-5 2015 Similarly to a STAT1 mutant with impaired tetramerization, the N-terminal gain-of-function mutants showed elevated tyrosine-phosphorylation levels and prolonged nuclear accumulation upon stimulation of cells with IFNgamma. Tyrosine 115-123 interferon gamma Homo sapiens 213-221 26162572-9 2015 IFN-gamma inhibited cTFH cell function in vitro and in vivo, as corroborated by hypergammaglobulinemia in patients with IFNGR1/2, STAT1, and IL12RB1 LOF mutations. ctfh 20-24 interferon gamma Homo sapiens 0-9 26283540-2 2015 Transcription of CIITA through the IFN-gamma inducible CIITA promoter IV (CIITA pIV) during activation is characterized by a decrease in trimethylation of histone H3 lysine 27 (H3K27me3), catalyzed by the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2). Lysine 166-172 interferon gamma Homo sapiens 35-44 26275957-11 2015 Treatment with 1.4 muM DMSO caused a time-dependent inhibition of cell proliferation at 24, 48 and 72 h. 1.4 muM DMSO caused a significant reduction in VEGF levels at 72 h of incubation and sharp increases in IFNgamma levels at both 48 and 72 h of incubation. Dimethyl Sulfoxide 23-27 interferon gamma Homo sapiens 209-217 26275957-11 2015 Treatment with 1.4 muM DMSO caused a time-dependent inhibition of cell proliferation at 24, 48 and 72 h. 1.4 muM DMSO caused a significant reduction in VEGF levels at 72 h of incubation and sharp increases in IFNgamma levels at both 48 and 72 h of incubation. Dimethyl Sulfoxide 113-117 interferon gamma Homo sapiens 209-217 26275957-12 2015 According to real time PCR analyses, DMSO (1.4 muM) exhibited an inhibitory effect on VEGF but acted as an augmenter of IFNgamma release on HeLa cells in vitro. Dimethyl Sulfoxide 37-41 interferon gamma Homo sapiens 120-128 26275957-13 2015 This is the first report showing that the general solvent DMSO suppressed HeLa cell proliferation, decreased the levels of two pro-angiogenic factors (substance P and VEGF) and increased the release of an anti-angiogenic factor IFNgamma in vitro. Dimethyl Sulfoxide 58-62 interferon gamma Homo sapiens 228-236 26168332-7 2015 Inhibition of caspase-1 activation using the specific inhibitor YVAD identified a homogenous non responder group featuring a caspase-1-independent IL-18/IFN-gamma response, and a heterogenous responder group, in which both IL-18 and IFN-gamma responses were caspase-1-dependent, with a 40-70% range of inhibition by YVAD. YVAD 64-68 interferon gamma Homo sapiens 153-162 25919809-0 2015 Detection of Interferon gamma using graphene and aptamer based FET-like electrochemical biosensor. Graphite 36-44 interferon gamma Homo sapiens 13-29 26758116-9 2015 (2) IL-1 beta, IL-4, IL-6, IL-8, IL-10, IFN-gamma in BALF of steroid group and non steroid group were both significantly higher than that of control group. Steroids 61-68 interferon gamma Homo sapiens 40-49 26758116-11 2015 (3) In steroid group, IL-2 and IL-8 in BALF of patient whose fever disappeared after steroid therapy were both significantly lower than that of patients who still had fever (t=2.771, 2.054, P=0.010, 0.049) , but no significant difference was found between the two groups in BALF IL-1 beta, IL-4, IL-6, IL-10, IFN-gamma levels (P>0.05). Steroids 7-14 interferon gamma Homo sapiens 309-318 26758116-13 2015 (2) Incresed BALF IL-1 beta, IL-4, IL-6, IL-8, IL-10, IFN-gamma levels were observed in RMPP and high level of BALF IL-2 and IL-8 might have some relevance with persistent fever of RMPP in children. rmpp 88-92 interferon gamma Homo sapiens 54-63 25919809-4 2015 A graphene monolayer-based FET-like structure is incorporated on a PDMS substrate with the IFN-gamma aptamer attached to graphene. Graphite 2-10 interferon gamma Homo sapiens 91-100 25919809-4 2015 A graphene monolayer-based FET-like structure is incorporated on a PDMS substrate with the IFN-gamma aptamer attached to graphene. Graphite 121-129 interferon gamma Homo sapiens 91-100 26102551-17 2015 Methanol and aqueous extracts increased the release of IFNgamma by PBMCs (p<0.05); however, methanol extracts were significantly more active than aqueous extracts (p<0.05). Methanol 0-8 interferon gamma Homo sapiens 55-63 26232434-0 2015 Parafibromin Is a Component of IFN-gamma-Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1. Tyrosine 103-111 interferon gamma Homo sapiens 31-40 26232434-5 2015 Overexpression of parafibromin promoted IFN-gamma-triggered phosphorylation of STAT1 at Tyr(701), subsequent expression of downstream genes, and cellular antiviral response, whereas knockdown of parafibromin had opposite effects. Tyrosine 88-91 interferon gamma Homo sapiens 40-49 26347149-3 2015 In this study, whether IFN-gamma can induce CD4(+)CD25(-) T cells into CD4(+)CD25(+) Tregs in MG in vitro was investigated systematically. tregs 85-90 interferon gamma Homo sapiens 23-32 26333527-8 2015 Furthermore, NBL IL-10, IL-13, GM-CSF and IFNgamma demonstrated positive associations with breath alkanes and alkenes. Alkanes 98-105 interferon gamma Homo sapiens 42-50 26333527-8 2015 Furthermore, NBL IL-10, IL-13, GM-CSF and IFNgamma demonstrated positive associations with breath alkanes and alkenes. Alkenes 110-117 interferon gamma Homo sapiens 42-50 26013040-0 2015 An interferon-gamma-delivery system based on chitosan/poly(gamma-glutamic acid) polyelectrolyte complexes modulates macrophage-derived stimulation of cancer cell invasion in vitro. poly(gamma-glutamic acid) 54-79 interferon gamma Homo sapiens 3-19 26013040-8 2015 Ch/gamma-PGA PEMs with IFN-gamma were able to modulate the phenotype of IL-10-treated macrophages at the cell cytoskeleton and cytokine profile levels, inducing an increase of IL-6 and a decrease of IL-10 production. poly(gamma-glutamic acid) 3-12 interferon gamma Homo sapiens 23-32 26013040-9 2015 More interestingly, the pro-invasive role of IL-10-treated macrophages was hindered, as their stimulation of gastric cancer cell invasion in vitro decreased from 4 to 2-fold, upon modulation by Ch/gamma-PGA PEMs with IFN-gamma. poly(gamma-glutamic acid) 197-206 interferon gamma Homo sapiens 217-226 26013040-10 2015 This is the first report proposing Ch/gamma-PGA PEMs as a suitable strategy to incorporate and release bioactive IFN-gamma with the aim of modulating macrophage phenotype, counteracting their stimulating role on gastric cancer cell invasion. poly(gamma-glutamic acid) 38-47 interferon gamma Homo sapiens 113-122 26468028-1 2015 An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-gamma and IL-2 by ConA-stimulated mononuclear cells. Flavonoids 54-66 interferon gamma Homo sapiens 101-110 26276009-5 2015 RESULTS: EBVmix induced significantly higher T-cell frequencies and allowed selecting more CD4(+)IFN-gamma(+) and CD8(+)IFN-gamma(+) cells than single peptide pools. ebvmix 9-15 interferon gamma Homo sapiens 97-106 26276009-5 2015 RESULTS: EBVmix induced significantly higher T-cell frequencies and allowed selecting more CD4(+)IFN-gamma(+) and CD8(+)IFN-gamma(+) cells than single peptide pools. ebvmix 9-15 interferon gamma Homo sapiens 120-129 26114249-7 2015 Administration of the glycolytic inhibitor 2-deoxy-glucose suppressed both glycolysis and respiration and exerted a strong impact on cytokine production that persisted for IFN-gamma after removal of 2-deoxy-glucose. Deoxyglucose 43-58 interferon gamma Homo sapiens 172-181 26468028-4 2015 The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-gamma content. Quercetin 19-38 interferon gamma Homo sapiens 123-132 26100037-10 2015 In addition, DHE-Glc suppressed TNF-alpha/IFN-gamma-induced expression of the Th2 chemokines CCL17 and CCL22 by inhibiting NF-kappaB and STAT activation in TNF-alpha/IFN-gamma-induced HaCaT cells. Dihydroergotamine 13-16 interferon gamma Homo sapiens 42-51 25998949-3 2015 Lymphocytes from 6 of 7 patients were found to proliferate and/or secrete interferon-gamma (IFN-gamma) when cultured with amoxicillin and/or clavulanic acid. Amoxicillin 122-133 interferon gamma Homo sapiens 74-90 25998949-3 2015 Lymphocytes from 6 of 7 patients were found to proliferate and/or secrete interferon-gamma (IFN-gamma) when cultured with amoxicillin and/or clavulanic acid. Amoxicillin 122-133 interferon gamma Homo sapiens 92-101 25998949-3 2015 Lymphocytes from 6 of 7 patients were found to proliferate and/or secrete interferon-gamma (IFN-gamma) when cultured with amoxicillin and/or clavulanic acid. Clavulanic Acid 141-156 interferon gamma Homo sapiens 74-90 25998949-3 2015 Lymphocytes from 6 of 7 patients were found to proliferate and/or secrete interferon-gamma (IFN-gamma) when cultured with amoxicillin and/or clavulanic acid. Clavulanic Acid 141-156 interferon gamma Homo sapiens 92-101 25998949-5 2015 Amoxicillin clones were found to secrete a heterogeneous panel of mediators, including IFN-gamma, interleukin-22 and cytolytic molecules. Amoxicillin 0-11 interferon gamma Homo sapiens 87-96 26100037-10 2015 In addition, DHE-Glc suppressed TNF-alpha/IFN-gamma-induced expression of the Th2 chemokines CCL17 and CCL22 by inhibiting NF-kappaB and STAT activation in TNF-alpha/IFN-gamma-induced HaCaT cells. Dihydroergotamine 13-16 interferon gamma Homo sapiens 166-175 26100037-10 2015 In addition, DHE-Glc suppressed TNF-alpha/IFN-gamma-induced expression of the Th2 chemokines CCL17 and CCL22 by inhibiting NF-kappaB and STAT activation in TNF-alpha/IFN-gamma-induced HaCaT cells. Glucose 17-20 interferon gamma Homo sapiens 42-51 26100037-10 2015 In addition, DHE-Glc suppressed TNF-alpha/IFN-gamma-induced expression of the Th2 chemokines CCL17 and CCL22 by inhibiting NF-kappaB and STAT activation in TNF-alpha/IFN-gamma-induced HaCaT cells. Glucose 17-20 interferon gamma Homo sapiens 166-175 26209622-3 2015 Modulation of the glucose metabolism contributes to the macrophage adaptation to the surrounding cytokine milieu, as exemplified by the distinct glucose catabolism of macrophages exposed to LPS/IFN-gamma or IL-4. Glucose 18-25 interferon gamma Homo sapiens 194-203 26209622-3 2015 Modulation of the glucose metabolism contributes to the macrophage adaptation to the surrounding cytokine milieu, as exemplified by the distinct glucose catabolism of macrophages exposed to LPS/IFN-gamma or IL-4. Glucose 145-152 interferon gamma Homo sapiens 194-203 26216888-10 2015 Production of the proinflammatory cytokine IFN-gamma, but not TNF-alpha or perforin, was essential to IL-15 SA-induced immunotoxicity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 108-110 interferon gamma Homo sapiens 43-52 25772594-0 2015 Distinct endotypes of steroid-resistant asthma characterized by IL-17A(high) and IFN-gamma(high) immunophenotypes: Potential benefits of calcitriol. Steroids 22-29 interferon gamma Homo sapiens 81-90 26232426-4 2015 RegDC generated from monocyte-derived DC treated either with LPS and dexamethasone, vitamin D3, or vitamin D3 and dexamethasone instructed NK cells to secrete lower amounts of IFN-gamma than NK cells exposed to mDC. Dexamethasone 69-82 interferon gamma Homo sapiens 176-185 26232426-4 2015 RegDC generated from monocyte-derived DC treated either with LPS and dexamethasone, vitamin D3, or vitamin D3 and dexamethasone instructed NK cells to secrete lower amounts of IFN-gamma than NK cells exposed to mDC. Cholecalciferol 99-109 interferon gamma Homo sapiens 176-185 26232426-4 2015 RegDC generated from monocyte-derived DC treated either with LPS and dexamethasone, vitamin D3, or vitamin D3 and dexamethasone instructed NK cells to secrete lower amounts of IFN-gamma than NK cells exposed to mDC. Dexamethasone 114-127 interferon gamma Homo sapiens 176-185 26232431-5 2015 During immunization with peptide in CFA, cholesterol-modified p40 siRNA generated p40-deficient, IL-10-producing DCs that prevented IL-17/Th17 and IFN-gamma/Th1 responses. Cholesterol 41-52 interferon gamma Homo sapiens 147-156 26232431-6 2015 Only cholesterol-modified p40-siRNA established protective immunity against experimental autoimmune encephalomyelitis and suppressed IFN-gamma and IL-17 expression by CNS-infiltrating mononuclear cells without inducing regulatory T cells. Cholesterol 5-16 interferon gamma Homo sapiens 133-142 26238487-11 2015 Pretreatment with sorafenib also inhibited PBMC expression of IFN-alpha- and IL-2-regulated genes and inhibited NK cell production of IFN-gamma, RANTES, MIP1-alpha, and MIG in response to IFN-alpha stimulation. Sorafenib 18-27 interferon gamma Homo sapiens 134-143 27057461-1 2016 As a part of cellular pathogen defense, IFNgamma triggers induction of NADPH oxidase NOX2, which produces superoxide into phagosomes of immune cells. Superoxides 106-116 interferon gamma Homo sapiens 40-48 26716206-5 2015 ZO-NP (10 mug/mL) inhibited the IFN-gamma plus LPS-induced production of nitric oxide and the protein expressions of inducible nitric oxide synthase and cyclooxygenase-2. zo-np 0-5 interferon gamma Homo sapiens 32-41 26716206-5 2015 ZO-NP (10 mug/mL) inhibited the IFN-gamma plus LPS-induced production of nitric oxide and the protein expressions of inducible nitric oxide synthase and cyclooxygenase-2. Nitric Oxide 73-85 interferon gamma Homo sapiens 32-41 26716206-7 2015 Furthermore, the up-regulations of IL-1beta and TNF-alpha mRNAs by IFN-gamma plus LPS were reduced by ZO-NP at low (0.1 mug/mL) and high (10 mug/mL) concentrations. zo-np 102-107 interferon gamma Homo sapiens 67-76 27057461-3 2016 IFNgamma is capable of inducing expression of constitutively active NADPH oxidase NOX4 in tumor cells leading to generation of reactive oxygen species (ROS) damaging DNA, activation of DNA damage response and cell cycle arrest/premature cellular senescence. Reactive Oxygen Species 152-155 interferon gamma Homo sapiens 0-8 27057461-3 2016 IFNgamma is capable of inducing expression of constitutively active NADPH oxidase NOX4 in tumor cells leading to generation of reactive oxygen species (ROS) damaging DNA, activation of DNA damage response and cell cycle arrest/premature cellular senescence. Reactive Oxygen Species 127-150 interferon gamma Homo sapiens 0-8 26217022-5 2015 The same oils at 0.5% concentration were evaluated for their influence on peripheral blood mononuclear cell (PBMC) survival over 48 hr and their ability to inhibit IFNgamma production in PBMCs activated by phytohemagglutinin (PHA) in ELISpot assays. Oils 9-13 interferon gamma Homo sapiens 164-172 25905982-5 2015 RESULTS: Tacrolimus significantly and SRL modestly inhibited interferon (IFN)-gamma (Th1) and IL-17 (Th17)-producing cells. Tacrolimus 9-19 interferon gamma Homo sapiens 61-83 25877908-14 2015 CONCLUSION: This study provides the novel insight that MTX treatment in JIA does not attenuate Teff function but, conversely, enhances T cell proliferation and IFN-gamma plasma concentrations in JIA patients. Methotrexate 55-58 interferon gamma Homo sapiens 160-169 26317224-1 2015 BACKGROUND: The cytokine and drug interferon-gamma enhances superoxide anion production by the antimicrobicidal Nox2 enzyme of neutrophils. Superoxides 60-76 interferon gamma Homo sapiens 34-50 26317224-3 2015 Effects of INF-Gamma on NOX2 activity: To address this possibility we exposed the myeloid PLB-985 cell line to interferon-gamma for 3 days in the presence of dimethyl sulfoxide which induces terminal differentiation of these cells. Dimethyl Sulfoxide 158-176 interferon gamma Homo sapiens 111-127 26317224-4 2015 Interferon-gamma was found to enhance superoxide production by Nox2 in a concentration dependent manner. Superoxides 38-48 interferon gamma Homo sapiens 0-16 26317224-6 2015 Additionally, application of interferon-gamma for 3 hours to pre-differentiated PLB-985 cells, which models studies using isolated neutrophils, was much less effective at enhancing superoxide anion production. Superoxides 181-197 interferon gamma Homo sapiens 29-45 26317224-9 2015 Thus, increased levels of gp91phox, p47phox and p22phox likely account for the interferon-gamma mediated enhancement of dimethyl sulfoxide-induced Nox2 activity. Dimethyl Sulfoxide 120-138 interferon gamma Homo sapiens 79-95 26285873-12 2015 Patients" kynurenine pathway metabolites correlated with the levels of inflammatory markers, including that of the major IDO-inducer, interferon-gamma. Kynurenine 10-20 interferon gamma Homo sapiens 134-150 26285203-6 2015 As for the mechanisms underlying pamidronate-based therapy, our in vitro data demonstrated that its antiviral effects were partly mediated by IFN-gamma secreted from human Vdelta2-T cells. Pamidronate 33-44 interferon gamma Homo sapiens 142-151 26092996-4 2015 We hypothesized that IFN-gamma-induced JAK/STAT-associated signaling pathways in airway epithelial cells are insensitive to GCs and that strategies aimed at inhibiting JAK/STAT pathways can restore steroid responsiveness. Steroids 198-205 interferon gamma Homo sapiens 21-30 26268522-9 2015 CD4+CD25+ enriched PBL stimulated with PMA/Ionomycin in the presence of rIFNgamma were rather resistant to the effect of rIFNgamma, in contrast to CD4+CD25- enriched PBL which showed increasing total Treg with Helios+ Treg switching from IFNgamma- to IFNgamma+ and increasing Helios-IFNgamma+ Treg. Tetradecanoylphorbol Acetate 39-42 interferon gamma Homo sapiens 73-81 26268522-9 2015 CD4+CD25+ enriched PBL stimulated with PMA/Ionomycin in the presence of rIFNgamma were rather resistant to the effect of rIFNgamma, in contrast to CD4+CD25- enriched PBL which showed increasing total Treg with Helios+ Treg switching from IFNgamma- to IFNgamma+ and increasing Helios-IFNgamma+ Treg. Ionomycin 43-52 interferon gamma Homo sapiens 73-81 26268522-11 2015 When phorbol 12-myristate 13-acetate (PMA)/Ionomycin was washed out from the cell culture after 6 h stimulation, Treg induction continued for at least 96 h of cell culture, contradicting the hypothesis that removal of the stimulus results in significant decrease of IFNgamma- and IFNgamma+ CD4+CD25+Foxp3+CD127- Treg due to loss of Foxp3 expression. Tetradecanoylphorbol Acetate 5-36 interferon gamma Homo sapiens 266-288 26268522-11 2015 When phorbol 12-myristate 13-acetate (PMA)/Ionomycin was washed out from the cell culture after 6 h stimulation, Treg induction continued for at least 96 h of cell culture, contradicting the hypothesis that removal of the stimulus results in significant decrease of IFNgamma- and IFNgamma+ CD4+CD25+Foxp3+CD127- Treg due to loss of Foxp3 expression. Tetradecanoylphorbol Acetate 38-41 interferon gamma Homo sapiens 266-288 27057439-6 2016 Strikingly, the simultaneous dual local delivery of celecoxib and PD-1 from this hydrogel system synergistically enhanced the presence of CD4+inteferon (IFN)-gamma+ and CD8+IFN-gamma+ T cells within the tumor as well as in the immune system. Celecoxib 52-61 interferon gamma Homo sapiens 138-163 27141373-2 2016 In the two phase-I trials that we conducted using the first generation of Dex (IFN-gamma-free) in end-stage cancer, we reported that Dex exerted natural killer (NK) cell effector functions in patients. dex 74-77 interferon gamma Homo sapiens 79-88 27141373-2 2016 In the two phase-I trials that we conducted using the first generation of Dex (IFN-gamma-free) in end-stage cancer, we reported that Dex exerted natural killer (NK) cell effector functions in patients. dex 133-136 interferon gamma Homo sapiens 79-88 26101276-5 2015 At inclusion, the presence of circulating IFN-gamma, a higher CD4(+) T cell count and having initiated intermittent preventive treatment of malaria with sulfadoxine pyrimethamine (SP-IPTp) were all associated with a lower likelihood of Plasmodium falciparum infection. fanasil, pyrimethamine drug combination 153-178 interferon gamma Homo sapiens 42-51 26051830-8 2015 RESULTS: Ethanol extract of XF (EXF) inhibited mRNA expression and production of TARC/CCL17 and MDC/CCL22 induced by TNF-alpha/IFN-gamma in a dose-dependent manner. Ethanol 9-16 interferon gamma Homo sapiens 127-136 26101276-5 2015 At inclusion, the presence of circulating IFN-gamma, a higher CD4(+) T cell count and having initiated intermittent preventive treatment of malaria with sulfadoxine pyrimethamine (SP-IPTp) were all associated with a lower likelihood of Plasmodium falciparum infection. sp-iptp 180-187 interferon gamma Homo sapiens 42-51 26142328-7 2015 Both a nuclear factor-kappaB inhibitor (PDTC) and an intracellular calcium antagonist (TMB-8) prevented upregulation of IFN-gamma production. Calcium 67-74 interferon gamma Homo sapiens 120-129 26113434-1 2015 TB vaccine discovery has focused on IFN-gamma both for the selection of antigens and vaccine delivery strategies. Terbium 0-2 interferon gamma Homo sapiens 36-45 26142328-7 2015 Both a nuclear factor-kappaB inhibitor (PDTC) and an intracellular calcium antagonist (TMB-8) prevented upregulation of IFN-gamma production. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 87-92 interferon gamma Homo sapiens 120-129 26142328-9 2015 Interestingly, a combined p38gamma and p38delta inhibitor (BIRB796) significantly decreased IFN-gamma production. doramapimod 59-66 interferon gamma Homo sapiens 92-101 26330806-9 2015 We demonstrated that T-bet expression induced by ecdysone treatment in human embryonic kidney (HEK) cells increased IFN-gamma promoter activity in a dose dependent manner, and sustained T-bet expression considerably decreased cell proliferation in HEK cells. Ecdysone 49-57 interferon gamma Homo sapiens 116-125 25769179-8 2015 RESULTS: Interquartile range increases in particle number, PM2.5 black carbon, and PM2.5 mass concentrations were associated with significantly lower methylation in the lower tails of the IFN-gamma and ICAM-1 methylation distributions. Carbon 71-77 interferon gamma Homo sapiens 188-197 25772595-7 2015 Here we demonstrate the role of miR-9 in IFN-gamma/LPS-induced inhibition of dexamethasone (DEX) signaling in macrophages and in induction of steroid-resistant AHR. Dexamethasone 77-90 interferon gamma Homo sapiens 41-50 25772595-6 2015 OBJECTIVE: IFN-gamma and LPS synergistically increase the expression of miR-9 in macrophages and lung tissue, suggesting a role in the mechanisms of steroid resistance. Steroids 149-156 interferon gamma Homo sapiens 11-20 25772595-7 2015 Here we demonstrate the role of miR-9 in IFN-gamma/LPS-induced inhibition of dexamethasone (DEX) signaling in macrophages and in induction of steroid-resistant AHR. Dexamethasone 92-95 interferon gamma Homo sapiens 41-50 25772595-7 2015 Here we demonstrate the role of miR-9 in IFN-gamma/LPS-induced inhibition of dexamethasone (DEX) signaling in macrophages and in induction of steroid-resistant AHR. Steroids 142-149 interferon gamma Homo sapiens 41-50 25772595-12 2015 RESULTS: Exposure of pulmonary macrophages to IFN-gamma/LPS synergistically induced miR-9 expression; reduced levels of its target transcript, protein phosphatase 2 regulatory subunit B (B56) delta isoform; attenuated PP2A activity; and inhibited DEX-induced GR nuclear translocation. Dexamethasone 247-250 interferon gamma Homo sapiens 46-55 25822580-4 2015 Co-stimulation with IFN-gamma and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-beta, IL-6, IL-8, and human beta-defensin-2 in NHEKs compared with poly (I:C) or IFN-gamma alone. poly 50-54 interferon gamma Homo sapiens 190-199 25822580-4 2015 Co-stimulation with IFN-gamma and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-beta, IL-6, IL-8, and human beta-defensin-2 in NHEKs compared with poly (I:C) or IFN-gamma alone. Iodine 20-21 interferon gamma Homo sapiens 190-199 25822580-4 2015 Co-stimulation with IFN-gamma and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-beta, IL-6, IL-8, and human beta-defensin-2 in NHEKs compared with poly (I:C) or IFN-gamma alone. Carbon 0-1 interferon gamma Homo sapiens 20-29 25822580-4 2015 Co-stimulation with IFN-gamma and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-beta, IL-6, IL-8, and human beta-defensin-2 in NHEKs compared with poly (I:C) or IFN-gamma alone. Carbon 0-1 interferon gamma Homo sapiens 190-199 25936741-8 2015 IFN-gamma/TNF-alpha ratio against Rv3716c and TrxC has exhibited a positivity of 94.29% in HHC and 5% in PTB group. 6-thiotheophylline 105-108 interferon gamma Homo sapiens 0-9 26051078-10 2015 RESULTS: Interferon gamma (FN-gamma) treatment significantly abrogated the differentiation potential of DPSCs as shown by using alizarin red and alkaline phosphatase activity analysis. alizarin 128-140 interferon gamma Homo sapiens 9-25 26078271-0 2015 A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-gamma Production. Glycolipids 8-18 interferon gamma Homo sapiens 69-78 26021804-8 2015 IFN-gamma treatment dampened N-MDICs-mediated T cell activation through up-regulating T cell suppressive mediators, reactive oxygen species (ROS) and arginase I. Reactive Oxygen Species 116-139 interferon gamma Homo sapiens 0-9 26021804-8 2015 IFN-gamma treatment dampened N-MDICs-mediated T cell activation through up-regulating T cell suppressive mediators, reactive oxygen species (ROS) and arginase I. Reactive Oxygen Species 141-144 interferon gamma Homo sapiens 0-9 25648880-7 2015 Glomerular IFN-gamma and IL-17 staining grades correlated with the urinary protein/creatinine ratio (r = 0.62, p = 0.02 and r = 0.507, p = 0.016, respectively). Creatinine 83-93 interferon gamma Homo sapiens 11-20 25953702-6 2015 NSAIDs that are acetic acid (AA) derivatives and associated with IDILI synergized with TNFalpha in causing cytotoxicity in HepG2 cells, and IFNgamma enhanced this interaction. Acetic Acid 16-27 interferon gamma Homo sapiens 140-148 25818476-0 2015 Interferon-gamma stimulates human follicular dendritic cell-like cells to produce prostaglandins via the JAK-STAT pathway. Prostaglandins 82-96 interferon gamma Homo sapiens 0-16 25818476-2 2015 Paying attention to the emerging role of prostaglandins (PGs) as immune regulators, we attempted to establish the effect of IFN-gamma on PG production in human follicular dendritic cell-like HK cells and the underlying signaling pathway by using RNA interference technology. Prostaglandins 41-55 interferon gamma Homo sapiens 124-133 25818476-7 2015 Finally, we demonstrated that JAK1, JAK2, and STAT1 were indispensable for the actual enhancement of PG production in response to IFN-gamma stimulation. Prostaglandins 101-103 interferon gamma Homo sapiens 130-139 25818476-8 2015 These results provide a novel insight into our understanding of IFN-gamma under inflammatory conditions and support the emerging concept of PGs as important immune regulators. Prostaglandins 140-143 interferon gamma Homo sapiens 64-73 26703340-12 2015 The suppression of IFN-gamma, TGF-beta or Th1/Th2 balance may be an important factor influencing the prognosis of TB. Terbium 114-116 interferon gamma Homo sapiens 19-28 26153897-8 2015 Additionally, we revealed that nanovaccine effectively enhanced IFN-gamma secretion and CD8(+) T cell response. nanovaccine 31-42 interferon gamma Homo sapiens 64-73 25990221-10 2015 Moreover, cytotoxic Th1 cytokines, including IL2, IL12p40, and IFNgamma, as well as activated CD8(+) T cells were elevated in tumors receiving post-IR L-NAME. NG-Nitroarginine Methyl Ester 151-157 interferon gamma Homo sapiens 63-71 26013832-9 2015 When co-cultured with ZOL-pretreated human osteoclasts in vitro, h-gammadelta T cells exhibited rapid expansion and robust IFN-gamma secretion. Zoledronic Acid 22-25 interferon gamma Homo sapiens 123-132 25999427-7 2015 Consistent with this hypothesis, exposure of NCM460 cells to the proinflammatory cytokines TNF-alpha and IFN-gamma led to a significant inhibition of biotin uptake, sodium-dependent multivitamin transporter expression, and activity of the SLC5A6 promoter. Biotin 150-156 interferon gamma Homo sapiens 105-114 26002964-4 2015 In addition, lenalidomide augments NK-cell responses, causing a twofold increase in the proportion of primary NK cells producing interferon-gamma (IFN-gamma), and a 20-fold increase in the amount of IFN-gamma produced per cell. Lenalidomide 13-25 interferon gamma Homo sapiens 129-145 26142316-0 2015 Silibinin down-regulates FAT10 and modulate TNF-alpha/IFN-gamma-induced chromosomal instability and apoptosis sensitivity. Silybin 0-9 interferon gamma Homo sapiens 54-63 26002964-4 2015 In addition, lenalidomide augments NK-cell responses, causing a twofold increase in the proportion of primary NK cells producing interferon-gamma (IFN-gamma), and a 20-fold increase in the amount of IFN-gamma produced per cell. Lenalidomide 13-25 interferon gamma Homo sapiens 147-156 26002964-4 2015 In addition, lenalidomide augments NK-cell responses, causing a twofold increase in the proportion of primary NK cells producing interferon-gamma (IFN-gamma), and a 20-fold increase in the amount of IFN-gamma produced per cell. Lenalidomide 13-25 interferon gamma Homo sapiens 199-208 26002964-9 2015 Finally, superresolution microscopy revealed that lenalidomide increased the periodicity of cortical actin at immune synapses, resulting in an increase in the area of the actin mesh predicted to be penetrable to vesicles containing IFN-gamma. Lenalidomide 50-62 interferon gamma Homo sapiens 232-241 25575728-10 2015 There was significant decrease in plasma IFN-gamma levels following five-day montelukast treatment (p=0.027, Wilcoxon). montelukast 77-88 interferon gamma Homo sapiens 41-50 25575728-13 2015 CONCLUSION: Our study showed that montelukast affected plasma IFN-gamma and eotaxin levels after five days of treatment. montelukast 34-45 interferon gamma Homo sapiens 62-71 25846669-3 2015 A clinical study was conducted in 18 stage IIIc/IV melanoma patients treated with tumor-infiltrating lymphocytes (TILs) in combination with intratumoral TG1042 injection (adenovirus expressing IFN-gamma). tg1042 153-159 interferon gamma Homo sapiens 193-202 25959810-8 2015 RESULTS: Retinoic acid acted synergistically with IL-2 and other activating cytokines to induce expression of the gut-homing integrin alpha4beta7 in ILCs, as well as production of IL-5 and IL-13 in ILC2 cells, and IFN-gamma in ILC1 and ILC3 cells. Tretinoin 9-22 interferon gamma Homo sapiens 214-223 24615891-6 2015 Results showed that Nrf2 protects against inflammation and oxidative damage induced by TiO2 NPs exposure, however, Nrf2 is a positive mediator in the expression of IFN-gamma, TNF-alpha, and TGF-beta in bronchial epithelium and alveolar space after 4 weeks of exposure. titanium dioxide 87-91 interferon gamma Homo sapiens 164-173 25432967-9 2015 For females, results from IFN-gamma-treated cells showed positive correlations between testosterone levels and IL-1beta responses to endotoxin for both risk groups and TNF-alpha for the high-risk group. Testosterone 87-99 interferon gamma Homo sapiens 26-35 26108267-6 2015 Culture of PBMCs from psoriasis patients and controls in the presence of DMF decreased IFN-gamma and increased IL-4 gene expression in both groups. Dimethyl Fumarate 73-76 interferon gamma Homo sapiens 87-96 26108267-8 2015 Decreased release of IFN-gamma and GM-CSF cytokine secretion after DMF treatment was also observed in PBMC cultures of patients and controls. Dimethyl Fumarate 67-70 interferon gamma Homo sapiens 21-30 26622301-8 2015 Moreover, rLPG3, CT, and NT fragments were markedly stimulated the secretion of IFN-gamma by NK cells (P<0.001). nt 25-27 interferon gamma Homo sapiens 80-89 25830506-10 2015 Inhibition of p38 MAP kinase by SB203580 prevented increases in paracellular permeability, actin rearrangement, and increases in the F-/G-actin ratio caused by IFN-gamma. SB 203580 32-40 interferon gamma Homo sapiens 160-169 25827682-9 2015 Transforming growth factor beta1 (TGFbeta1) is able to inhibit the IFNgamma-mediated activation of microglia, which is characterized by the release of nitric oxide (NO) and tumor necrosis factor alpha (TNFalpha). Nitric Oxide 151-163 interferon gamma Homo sapiens 67-75 25815463-4 2015 MHC I as well as the co-stimulatory molecules CD40 and CD80 were significantly increased following treatment with 5-Aza-CdR + SAHA + IFN-gamma (epigenetic groups) compared with those in the control group and IFN-gamma group (P<0.05). Vorinostat 126-130 interferon gamma Homo sapiens 208-217 25881570-0 2015 Alantolactone from Saussurea lappa Exerts Antiinflammatory Effects by Inhibiting Chemokine Production and STAT1 Phosphorylation in TNF-alpha and IFN-gamma-induced in HaCaT cells. alantolactone 0-13 interferon gamma Homo sapiens 145-154 25881570-8 2015 S. lappa and alantolactone suppressed the TNF-alpha and IFN-gamma-stimulated increase in the phosphorylation of STAT1. alantolactone 13-26 interferon gamma Homo sapiens 56-65 25881570-9 2015 Our results demonstrate that alantolactone from S. lappa suppresses TNF-alpha and IFN-gamma-induced production of RANTES and IL-8 by blocking STAT1 phosphorylation in HaCaT cells. alantolactone 29-42 interferon gamma Homo sapiens 82-91 25759117-0 2015 Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-gamma in primary macrophages requires endogenous 25-hydroxycholesterol synthesis. 25-hydroxycholesterol 137-158 interferon gamma Homo sapiens 77-93 26043674-9 2015 Importantly, LIPLAM induced higher IFNgamma production by primary human T-lymphocytes than purified LAM (2-16 times) or empty liposomes. liplam 13-19 interferon gamma Homo sapiens 35-43 26133047-3 2015 Nevertheless, only a DNA vaccine with Montanide GEL 01 PR and Montanide Essai 903110 induced viral-specific proliferation and the highest levels of IFN-gamma secretion. montanide 38-47 interferon gamma Homo sapiens 148-157 26133047-5 2015 It was observed that a DNA vaccine with Montanide Essai 903110 induced the highest BoHV-1 specific IFN-gamma production in cattle. montanide 40-49 interferon gamma Homo sapiens 99-108 26133047-5 2015 It was observed that a DNA vaccine with Montanide Essai 903110 induced the highest BoHV-1 specific IFN-gamma production in cattle. essai 903110 50-62 interferon gamma Homo sapiens 99-108 26121617-5 2015 When primary T cells transfected with NKT cell-derived TCR were subsequently stimulated with the NKT ligand, alpha-galactosylceramide (alpha-GalCer), they secreted IFN-gamma in a ligand-specific manner. alpha-galactosylceramide 109-133 interferon gamma Homo sapiens 164-173 26112052-10 2015 However, steroid treatment significantly decreased pro-inflammatory cytokines IL-1beta, IL-8, TNF and IFN-gamma at the time of organ procurement. Steroids 9-16 interferon gamma Homo sapiens 102-111 26114426-5 2015 This is the first study to show that up-regulation of indoleamine 2,3-dioxygenase (IDO-1), kynurenine 3-monoxygenase (KMO) and quinolinate phosphoribosyltransferase (QPRT) is lacking in lymphocytes treated with interferon gamma. 1H-indol-2-amine 54-65 interferon gamma Homo sapiens 211-227 26114426-6 2015 In contrast, peripheral monocytes showed a significant elevation of kynurenine pathway enzymes and metabolites when treated with interferon gamma. Kynurenine 68-78 interferon gamma Homo sapiens 129-145 26110640-14 2015 Dh404 significantly decreased production of cytokines/chemokines including IL-1beta, IL-6, IFN-gamma and MCP-1. dh404 0-5 interferon gamma Homo sapiens 91-100 25861939-12 2015 These results suggest that in PM, IFN-gamma and IL-7 might protect against poor pregnancy outcomes, which decrease plasma levels of progesterone, maternal haemoglobin and HDL-C, leading to low birth weight. Progesterone 132-144 interferon gamma Homo sapiens 34-43 25943251-6 2015 Biomolecules interferon-gamma (IFNgamma) and platelet-derived growth factor (PDGF) that selectively promote neuronal or oligodendrocyte lineage differentiation, respectively, are covalently cross-linked to the surface of the GO/PEDOT nanocomposite via carboxylic acid functional groups provided by GO using carbodiimide chemistry. Carboxylic Acids 252-267 interferon gamma Homo sapiens 13-29 26110930-1 2015 BACKGROUND: Interferon gamma (IFN-gamma) production induces the transcription of indoleamine 2,3 dioxygenase (IDO) resulting in the reduction of T-cell activation and proliferation through the depletion of tryptophan and the elicitation of Treg lymphocytes. Tryptophan 206-216 interferon gamma Homo sapiens 12-28 26110930-1 2015 BACKGROUND: Interferon gamma (IFN-gamma) production induces the transcription of indoleamine 2,3 dioxygenase (IDO) resulting in the reduction of T-cell activation and proliferation through the depletion of tryptophan and the elicitation of Treg lymphocytes. Tryptophan 206-216 interferon gamma Homo sapiens 30-39 25943251-6 2015 Biomolecules interferon-gamma (IFNgamma) and platelet-derived growth factor (PDGF) that selectively promote neuronal or oligodendrocyte lineage differentiation, respectively, are covalently cross-linked to the surface of the GO/PEDOT nanocomposite via carboxylic acid functional groups provided by GO using carbodiimide chemistry. Carboxylic Acids 252-267 interferon gamma Homo sapiens 31-39 25943251-6 2015 Biomolecules interferon-gamma (IFNgamma) and platelet-derived growth factor (PDGF) that selectively promote neuronal or oligodendrocyte lineage differentiation, respectively, are covalently cross-linked to the surface of the GO/PEDOT nanocomposite via carboxylic acid functional groups provided by GO using carbodiimide chemistry. Carbodiimides 307-319 interferon gamma Homo sapiens 13-29 25943251-6 2015 Biomolecules interferon-gamma (IFNgamma) and platelet-derived growth factor (PDGF) that selectively promote neuronal or oligodendrocyte lineage differentiation, respectively, are covalently cross-linked to the surface of the GO/PEDOT nanocomposite via carboxylic acid functional groups provided by GO using carbodiimide chemistry. Carbodiimides 307-319 interferon gamma Homo sapiens 31-39 25558873-3 2015 On one Au electrode, two kinds of signaling probes labeled by the thiolated ferrocene (Fc)- and methy blue (MB)- were designed to hybridize with IFN-gamma and Lys aptamers respectively to form partial complementary DNA duplexes. Gold 7-9 interferon gamma Homo sapiens 145-154 25558873-3 2015 On one Au electrode, two kinds of signaling probes labeled by the thiolated ferrocene (Fc)- and methy blue (MB)- were designed to hybridize with IFN-gamma and Lys aptamers respectively to form partial complementary DNA duplexes. thiolated 66-75 interferon gamma Homo sapiens 145-154 25558873-3 2015 On one Au electrode, two kinds of signaling probes labeled by the thiolated ferrocene (Fc)- and methy blue (MB)- were designed to hybridize with IFN-gamma and Lys aptamers respectively to form partial complementary DNA duplexes. ferrocene 76-85 interferon gamma Homo sapiens 145-154 26085921-5 2015 When NK cells are co-cultured with helper-dependent adenoviral (HD-Ad) vector activated macrophages, IFN-gamma cytokine expression by NK cells increased significantly, which was inhibited effectively by ruxolitinib and CAPE, and there was an additive effect when both inhibitors were used. ruxolitinib 203-214 interferon gamma Homo sapiens 101-110 26199949-12 2015 gag-specific T-cell responses were detected in 63% of participants by interferon-gamma enzyme-linked immunospot at the highest dose post boost. Glycosaminoglycans 0-3 interferon gamma Homo sapiens 70-86 25921411-3 2015 The results showed that CucE significantly inhibited the production of interleukin-2, tumor necrosis factor-alpha, and interferon-gamma in culture medium of cells treated with phorbol 12,13-dibutyrate (PDB) plus ionomycin (Ion). Phorbol 12,13-Dibutyrate 176-200 interferon gamma Homo sapiens 119-135 25921411-3 2015 The results showed that CucE significantly inhibited the production of interleukin-2, tumor necrosis factor-alpha, and interferon-gamma in culture medium of cells treated with phorbol 12,13-dibutyrate (PDB) plus ionomycin (Ion). Phorbol 12,13-Dibutyrate 202-205 interferon gamma Homo sapiens 119-135 25880101-2 2015 Interestingly, SK-10-2 induced the strongest T cell response to produce IFN-gamma whereas the others did not induce prominent IFN-gamma production despite they all induced remarkable T cell proliferation. sk-10-2 15-22 interferon gamma Homo sapiens 72-81 26539251-10 2015 The reversibility of these effects after withdrawal of the anesthetics was attenuated for TNF-alpha/IFN-gamma-stimulated MSCs exposed to ropivacaine and bupivacaine. Ropivacaine 137-148 interferon gamma Homo sapiens 100-109 25274036-1 2015 The objective of this study was to estimate the relationship between serum vitamin D (VitD) status and tuberculosis (TB) infection conversion (TBIC), measured by the tuberculin skin test (TST) and an interferon-gamma release assay, the QuantiFERON-TB Gold In-Tube (QFT-GIT) test, in the contacts of pulmonary TB patients in Castellon (Spain) in a prospective cohort study from 2010 to 2012. Vitamin D 75-84 interferon gamma Homo sapiens 200-216 25592248-6 2015 Lastly, we observed that IFN-gamma and IL-17 production by ex vivo re-stimulated dLNs cells is greatly increased during rejection, which it turns depends on RA synthesis, as shown in experiments using a specific RALDH inhibitor. Tretinoin 157-159 interferon gamma Homo sapiens 25-34 25887271-8 2015 However, oenothein B induced IFNgamma production by T cells from adult humans and cattle. oenothein B 9-20 interferon gamma Homo sapiens 29-37 25612073-4 2015 Interleukin-6 (IL-6), interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) secretion levels significantly decreased in the presence of metal particles, as measured by ELISA. Metals 156-161 interferon gamma Homo sapiens 22-38 25612073-4 2015 Interleukin-6 (IL-6), interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) secretion levels significantly decreased in the presence of metal particles, as measured by ELISA. Metals 156-161 interferon gamma Homo sapiens 40-49 25639585-3 2015 The aim of this study was two fold: (1) to establish if the administration of the proinflammatory cytokine interferon-gamma (IFN-gamma) and/or UVB radiation elicits differential KP expression patterns in human fibroblast and keratinocytes; and (2) to evaluate the effect of KP metabolites on intracellular nicotinamide adenine dinucleotide (NAD(+) ) levels, and cell viability. NAD 306-339 interferon gamma Homo sapiens 107-123 25639585-3 2015 The aim of this study was two fold: (1) to establish if the administration of the proinflammatory cytokine interferon-gamma (IFN-gamma) and/or UVB radiation elicits differential KP expression patterns in human fibroblast and keratinocytes; and (2) to evaluate the effect of KP metabolites on intracellular nicotinamide adenine dinucleotide (NAD(+) ) levels, and cell viability. NAD 306-339 interferon gamma Homo sapiens 125-134 25639585-3 2015 The aim of this study was two fold: (1) to establish if the administration of the proinflammatory cytokine interferon-gamma (IFN-gamma) and/or UVB radiation elicits differential KP expression patterns in human fibroblast and keratinocytes; and (2) to evaluate the effect of KP metabolites on intracellular nicotinamide adenine dinucleotide (NAD(+) ) levels, and cell viability. NAD 341-349 interferon gamma Homo sapiens 107-123 25639585-3 2015 The aim of this study was two fold: (1) to establish if the administration of the proinflammatory cytokine interferon-gamma (IFN-gamma) and/or UVB radiation elicits differential KP expression patterns in human fibroblast and keratinocytes; and (2) to evaluate the effect of KP metabolites on intracellular nicotinamide adenine dinucleotide (NAD(+) ) levels, and cell viability. NAD 341-349 interferon gamma Homo sapiens 125-134 27668268-5 2015 Lenalidomide increased the anti-tumor activities of XBP1-CTL memory subsets, which were associated with expression of Th1 transcriptional regulators (T-bet, Eomes) and Akt activation, thereby resulting in enhanced IFN-gamma production, granzyme B upregulation and specific CD28/CD38-positive and CTLA-4/PD-1-negative cell proliferation. Lenalidomide 0-12 interferon gamma Homo sapiens 214-223 26539251-10 2015 The reversibility of these effects after withdrawal of the anesthetics was attenuated for TNF-alpha/IFN-gamma-stimulated MSCs exposed to ropivacaine and bupivacaine. Bupivacaine 153-164 interferon gamma Homo sapiens 100-109 26062428-4 2015 The expressions of intracellular IFN-gamma and TNF-alpha were analyzed by flow cytometry after the treatment with phorbol 12-myristate 13-acetate (PMA), brefeldin A (BFA) or ionomycin in vitro. Tetradecanoylphorbol Acetate 114-145 interferon gamma Homo sapiens 33-42 26062428-4 2015 The expressions of intracellular IFN-gamma and TNF-alpha were analyzed by flow cytometry after the treatment with phorbol 12-myristate 13-acetate (PMA), brefeldin A (BFA) or ionomycin in vitro. Tetradecanoylphorbol Acetate 147-150 interferon gamma Homo sapiens 33-42 26062428-4 2015 The expressions of intracellular IFN-gamma and TNF-alpha were analyzed by flow cytometry after the treatment with phorbol 12-myristate 13-acetate (PMA), brefeldin A (BFA) or ionomycin in vitro. Brefeldin A 153-164 interferon gamma Homo sapiens 33-42 26062428-4 2015 The expressions of intracellular IFN-gamma and TNF-alpha were analyzed by flow cytometry after the treatment with phorbol 12-myristate 13-acetate (PMA), brefeldin A (BFA) or ionomycin in vitro. Brefeldin A 166-169 interferon gamma Homo sapiens 33-42 26062428-7 2015 RESULTS: Compared with healthy controls, CHB patients presented with significantly decreased peripheral blood NK/NKT cell ratio and significantly elevated proportions of NKG2A+ NK and NKG2A+NKT cells, and after the treatment with PMA/BFA/ionomycin, IFN-gamma+ NK and IFN-gamma+ NKT cells were significantly reduced in CHB patients. Tetradecanoylphorbol Acetate 230-233 interferon gamma Homo sapiens 249-258 26062428-7 2015 RESULTS: Compared with healthy controls, CHB patients presented with significantly decreased peripheral blood NK/NKT cell ratio and significantly elevated proportions of NKG2A+ NK and NKG2A+NKT cells, and after the treatment with PMA/BFA/ionomycin, IFN-gamma+ NK and IFN-gamma+ NKT cells were significantly reduced in CHB patients. Tetradecanoylphorbol Acetate 230-233 interferon gamma Homo sapiens 267-276 26134016-6 2015 The results showed that co-cultured system contribted to a markedly increased production of IFN-gamma, after adding pomalidomide to the co-cultured system. pomalidomide 116-128 interferon gamma Homo sapiens 92-101 26134016-9 2015 Pomalidomide could promote CD138-CAR-T cells IFN-gamma production. pomalidomide 0-12 interferon gamma Homo sapiens 45-54 26024228-11 2015 However, pentoxifylline diminished secretion of TNF-alpha, IFN-gamma and IL-13, cytokines associated with the outcome of infection by species of the Viannia subgenus. Pentoxifylline 9-23 interferon gamma Homo sapiens 59-68 25724683-5 2015 Up-regulation of Nrf-2 by delta-Toc coincided with a decrease in GSH/GSSG ratio, thus pointing to pro-oxidant activity of delta-Toc isoform in IFNgamma/PMA-stimulated Caco-2 cells. Glutathione Disulfide 65-68 interferon gamma Homo sapiens 143-151 25724683-5 2015 Up-regulation of Nrf-2 by delta-Toc coincided with a decrease in GSH/GSSG ratio, thus pointing to pro-oxidant activity of delta-Toc isoform in IFNgamma/PMA-stimulated Caco-2 cells. Glutathione Disulfide 69-73 interferon gamma Homo sapiens 143-151 25724683-6 2015 The induction of oxidative stress in IFNgamma/PMA-treated cells by delta-Toc was lowered (P < 0.05) in the presence of ascorbic acid. delta-toc 67-76 interferon gamma Homo sapiens 37-45 25724683-6 2015 The induction of oxidative stress in IFNgamma/PMA-treated cells by delta-Toc was lowered (P < 0.05) in the presence of ascorbic acid. Ascorbic Acid 122-135 interferon gamma Homo sapiens 37-45 32262296-4 2015 For synthesizing the nanoparticle anti-tumor drug used against HCC, the liquid photo-immobilization method is used to bond the photoactive N-isopropylacrylamide derivative (NIPAm-AA) onto the oleic acid monolayer for subsequently embedding doxorubicin, photoactive tumor necrosis factor-alpha (TNF-alpha)/interferon-gamma (IFN-gamma), and folic acid (FOL). N-isopropylacrylamide 139-160 interferon gamma Homo sapiens 305-321 32262296-4 2015 For synthesizing the nanoparticle anti-tumor drug used against HCC, the liquid photo-immobilization method is used to bond the photoactive N-isopropylacrylamide derivative (NIPAm-AA) onto the oleic acid monolayer for subsequently embedding doxorubicin, photoactive tumor necrosis factor-alpha (TNF-alpha)/interferon-gamma (IFN-gamma), and folic acid (FOL). N-isopropylacrylamide 139-160 interferon gamma Homo sapiens 323-332 32262296-4 2015 For synthesizing the nanoparticle anti-tumor drug used against HCC, the liquid photo-immobilization method is used to bond the photoactive N-isopropylacrylamide derivative (NIPAm-AA) onto the oleic acid monolayer for subsequently embedding doxorubicin, photoactive tumor necrosis factor-alpha (TNF-alpha)/interferon-gamma (IFN-gamma), and folic acid (FOL). nipam-aa 173-181 interferon gamma Homo sapiens 305-321 32262296-4 2015 For synthesizing the nanoparticle anti-tumor drug used against HCC, the liquid photo-immobilization method is used to bond the photoactive N-isopropylacrylamide derivative (NIPAm-AA) onto the oleic acid monolayer for subsequently embedding doxorubicin, photoactive tumor necrosis factor-alpha (TNF-alpha)/interferon-gamma (IFN-gamma), and folic acid (FOL). nipam-aa 173-181 interferon gamma Homo sapiens 323-332 32262296-4 2015 For synthesizing the nanoparticle anti-tumor drug used against HCC, the liquid photo-immobilization method is used to bond the photoactive N-isopropylacrylamide derivative (NIPAm-AA) onto the oleic acid monolayer for subsequently embedding doxorubicin, photoactive tumor necrosis factor-alpha (TNF-alpha)/interferon-gamma (IFN-gamma), and folic acid (FOL). Oleic Acid 192-202 interferon gamma Homo sapiens 305-321 32262296-4 2015 For synthesizing the nanoparticle anti-tumor drug used against HCC, the liquid photo-immobilization method is used to bond the photoactive N-isopropylacrylamide derivative (NIPAm-AA) onto the oleic acid monolayer for subsequently embedding doxorubicin, photoactive tumor necrosis factor-alpha (TNF-alpha)/interferon-gamma (IFN-gamma), and folic acid (FOL). Oleic Acid 192-202 interferon gamma Homo sapiens 323-332 26052286-7 2015 In a co-culture of cancer cells with NK cells, interferon-gamma (IFN-gamma) production by NK cells was not altered by omega-3 fatty acids with anti-oxidants or by RvD1 but was inhibited by curcuminoids. curcuminoids 189-201 interferon gamma Homo sapiens 47-63 26052286-7 2015 In a co-culture of cancer cells with NK cells, interferon-gamma (IFN-gamma) production by NK cells was not altered by omega-3 fatty acids with anti-oxidants or by RvD1 but was inhibited by curcuminoids. curcuminoids 189-201 interferon gamma Homo sapiens 65-74 26221205-6 2015 Various cytokines IL-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-14, TNF-alpha and IFN-gamma are found in thyroid follicular cells which enhance inflammatory response with nitric oxide (NO) and prostaglandins. Nitric Oxide 194-206 interferon gamma Homo sapiens 105-114 26221205-6 2015 Various cytokines IL-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-14, TNF-alpha and IFN-gamma are found in thyroid follicular cells which enhance inflammatory response with nitric oxide (NO) and prostaglandins. Prostaglandins 216-230 interferon gamma Homo sapiens 105-114 25948100-5 2015 The levels of interferon-gamma (IFN-gamma) and interleukin-17 (IL-17) secreted by T cells stimulated with PMA and ionomycin were also determined by flow cytometry. Tetradecanoylphorbol Acetate 106-109 interferon gamma Homo sapiens 14-30 25948100-5 2015 The levels of interferon-gamma (IFN-gamma) and interleukin-17 (IL-17) secreted by T cells stimulated with PMA and ionomycin were also determined by flow cytometry. Ionomycin 114-123 interferon gamma Homo sapiens 14-30 24985791-6 2015 RESULTS: The levels of the analyzed cytokines and chemokines were significantly higher in the NPA of RSV-AB group, with a decrease in IL-4/IFNgamma ratio. rsv-ab 101-107 interferon gamma Homo sapiens 139-147 25995822-0 2015 Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-gamma Stimulated HaCaT Human Keratinocytes. dieckol 0-7 interferon gamma Homo sapiens 115-131 26502610-7 2015 When evaluating the effect of (-)-cytisine derivatives on activity of NF-kappaB and STATI, induced by specific agents (TNFalpha and IFNgamma, respectively) we observed that some compounds inhibited basal and stimulated activity of NF-kappaB and STAT1, another compounds showed the dual effect (an increase of basal- and a decrease of stimulated NF-kappaB activity) and several compounds increase both basal and induced activity of NF-kappaB and STAT1. cytisine 30-42 interferon gamma Homo sapiens 132-140 25995822-5 2015 Dieckol inhibited MDC/CCL22 production induced by IFN-gamma (10 ng/mL) in a dose dependent manner. dieckol 0-7 interferon gamma Homo sapiens 50-59 25248565-0 2015 Resveratrol regulates naive CD 8+ T-cell proliferation by upregulating IFN-gamma-induced tryptophanyl-tRNA synthetase expression. Resveratrol 0-11 interferon gamma Homo sapiens 71-80 25248565-1 2015 We found that resveratrol enhances interferon (IFN)-gamma-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow- derived dendritic cells (BMDCs). Resveratrol 14-25 interferon gamma Homo sapiens 35-57 25248565-3 2015 In addition, we found that resveratrol regulates naive CD8+ T-cell polarization by modulating GSK-3beta activity in IFN-gamma-stimulated BMDCs, and that resveratol induces upregulation of TTS in CD8+ T-cells in the in vivo tumor environment. Resveratrol 27-38 interferon gamma Homo sapiens 116-125 25248565-4 2015 Taken together, resveratrol upregulates IFN-gamma-induced TTS expression in a GSK-3beta-dependent manner, and this TTS modulation is crucial for DC-mediated T-cell modulation. Resveratrol 16-27 interferon gamma Homo sapiens 40-49 25582402-9 2015 Treatment with 100 nM dexamethasone enhanced the M2 morphotype and CD163 expression while preventing LPS/IFN-gamma-induced CD163 down-regulation. Dexamethasone 22-35 interferon gamma Homo sapiens 105-114 25774595-0 2015 Risk model incorporating donor IL6 and IFNG genotype and gastrointestinal GVHD can discriminate patients at high risk of steroid refractory acute GVHD. Steroids 121-128 interferon gamma Homo sapiens 39-43 25559144-4 2015 However, TNF-alpha also decreased poly(I:C)-induced production of interleukin (IL)-12 and IL-23 by MoDCs, which correlated with their diminished capacity to stimulate cellular proliferation, interferon-gamma and IL-17 production by allogeneic CD4(+)T cells in co-culture. Poly I-C 34-43 interferon gamma Homo sapiens 191-207 24357260-5 2015 This study shows that both TBT and DBT alter secretion of IFNgamma from human immune cells. tributyltin 27-30 interferon gamma Homo sapiens 58-66 24357260-5 2015 This study shows that both TBT and DBT alter secretion of IFNgamma from human immune cells. di-n-butyltin 35-38 interferon gamma Homo sapiens 58-66 24357260-7 2015 IFNgamma secretion was examined after 24 h, 48 h, and 6 day exposures to TBT (200 - 2.5 nM) and DBT (5 - 0.05 microM) in highly enriched human NK cells, a monocyte-depleted preparation of PBMCs, and monocyte-containing PBMCs. tributyltin 73-76 interferon gamma Homo sapiens 0-8 24357260-7 2015 IFNgamma secretion was examined after 24 h, 48 h, and 6 day exposures to TBT (200 - 2.5 nM) and DBT (5 - 0.05 microM) in highly enriched human NK cells, a monocyte-depleted preparation of PBMCs, and monocyte-containing PBMCs. di-n-butyltin 96-99 interferon gamma Homo sapiens 0-8 24357260-10 2015 The majority of donors showed an increase in IFNgamma secretion in response to at least one concentration of TBT or DBT at a minimum of one length of exposure. tributyltin 109-112 interferon gamma Homo sapiens 45-53 24357260-10 2015 The majority of donors showed an increase in IFNgamma secretion in response to at least one concentration of TBT or DBT at a minimum of one length of exposure. di-n-butyltin 116-119 interferon gamma Homo sapiens 45-53 25608587-0 2015 Isoniazid treatment to prevent TB in kidney and pancreas transplant recipients based on an interferon-gamma-releasing assay: an exploratory randomized controlled trial. Isoniazid 0-9 interferon gamma Homo sapiens 91-107 25608587-1 2015 BACKGROUND: We performed a randomized trial of isoniazid treatment based on interferon-gamma-releasing assay (IGRA) in kidney transplant (KT) recipients in an intermediate-TB-burden country. Isoniazid 47-56 interferon gamma Homo sapiens 76-92 25925198-6 2015 L-Arg treatment increased the population of CD4(+)T-bet(+)IFN-gamma(+) Th1 cells and the activated macrophages (F4/80(+)CD36(+)) in the spleen. Arginine 0-5 interferon gamma Homo sapiens 58-67 25925198-7 2015 The levels of pro-inflammatory cytokines, IFN-gamma and TNF-alpha, in splenocyte cultures were also increased by L-Arg treatment. Arginine 113-118 interferon gamma Homo sapiens 42-51 25837441-3 2015 METHODS: We determined whether anti-tuberculous antibiotics or dexamethasone affect the production of IFN-gamma and other potential cytokine biomarkers (TNF-alpha, IL-1ra, IL-2, IL-10, IL-13, IP-10, MIP-1beta) in the QuantiFERON-TB Gold In-Tube (QFT-IT) assay. Dexamethasone 63-76 interferon gamma Homo sapiens 102-111 25837441-8 2015 CONCLUSION: Substantial changes in TB-antigen-induced IFN-gamma and other cytokine responses during treatment likely primarily reflect host immunological changes rather than immunomodulatory effects of anti-tuberculous antibiotics. Terbium 35-37 interferon gamma Homo sapiens 54-63 25909817-4 2015 Furthermore, we showed that the over-expression of miR-362-5p enhanced the expression of IFN-gamma, perforin, granzyme-B, and CD107a in human primary NK cells, and we found that silencing CYLD with a small interfering RNA (siRNA) mirrored the effect of miR-362-5p over-expression. 362-5p 55-61 interferon gamma Homo sapiens 89-98 25898005-8 2015 Second, we found that CDG selectively activated pinocytosis-efficient-DCs, leading to T(H) polarizing cytokines IL-12p70, IFNgamma, IL-5, IL-13, IL-23, and IL-6 production in vivo. bis(3',5')-cyclic diguanylic acid 22-25 interferon gamma Homo sapiens 122-130 25707990-5 2015 Using functional readouts (IFN-gamma ELISpot and cell proliferation) and analyzing phenotypical hallmarks of CD4T cell differentiation, we show that carbopol improves cellular immunity by inducing early IFN-gamma-producing cells and by preferentially driving T cell differentiation to effector phenotypes. carboxypolymethylene 149-157 interferon gamma Homo sapiens 27-36 25707990-5 2015 Using functional readouts (IFN-gamma ELISpot and cell proliferation) and analyzing phenotypical hallmarks of CD4T cell differentiation, we show that carbopol improves cellular immunity by inducing early IFN-gamma-producing cells and by preferentially driving T cell differentiation to effector phenotypes. carboxypolymethylene 149-157 interferon gamma Homo sapiens 203-212 25627077-10 2015 In mixed cell cultures containing both T cells (CD4 and CD8alpha) and DCs, haloperidol-treated DCs suppressed the proliferation of allogeneic T cells and effectively inhibited the production of interferon-gamma. Haloperidol 75-86 interferon gamma Homo sapiens 194-210 25834353-6 2015 RESULTS: TNF-alpha- and IFN-gamma-induced CCL22 production was inhibited by PD98059, PD153035, Bay 11-7085, SB202190, c-Jun N-terminal kinase (JNK) inhibitor II, and Janus kinase (JAK) inhibitor 1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 76-83 interferon gamma Homo sapiens 24-33 25834353-6 2015 RESULTS: TNF-alpha- and IFN-gamma-induced CCL22 production was inhibited by PD98059, PD153035, Bay 11-7085, SB202190, c-Jun N-terminal kinase (JNK) inhibitor II, and Janus kinase (JAK) inhibitor 1. 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline 85-93 interferon gamma Homo sapiens 24-33 25834353-6 2015 RESULTS: TNF-alpha- and IFN-gamma-induced CCL22 production was inhibited by PD98059, PD153035, Bay 11-7085, SB202190, c-Jun N-terminal kinase (JNK) inhibitor II, and Janus kinase (JAK) inhibitor 1. BAY 11-7085 95-106 interferon gamma Homo sapiens 24-33 25834353-6 2015 RESULTS: TNF-alpha- and IFN-gamma-induced CCL22 production was inhibited by PD98059, PD153035, Bay 11-7085, SB202190, c-Jun N-terminal kinase (JNK) inhibitor II, and Janus kinase (JAK) inhibitor 1. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 108-116 interferon gamma Homo sapiens 24-33 25616369-3 2015 The results of such a study revealed for the first time that NFkB induced miR-2909 RNomics is crucial for the regulation of RelA translocation within human PBMCs exposed to high glucose thereby enabling these epigenetically programmed cells to tailor immune response involving genes coding for CCL5; IFN-gamma and IL-17. Glucose 178-185 interferon gamma Homo sapiens 300-309 25673640-2 2015 In this study, we demonstrate that immune suppression with cyclosporin after SCT limits T-helper cell (Th) 1 differentiation and interferon-gamma secretion by donor T cells, which is critical for inhibiting interleukin (IL)-6 generation from lung parenchyma during an alloimmune response. Cyclosporine 59-70 interferon gamma Homo sapiens 129-145 25708600-6 2015 RESULTS: Niclosamide reduced the secretion of IL-1beta, IL-6, IL-8, IL-17A and IFN-gamma from TNF-alpha-induced RA FLS in a dose-dependent manner. Niclosamide 9-20 interferon gamma Homo sapiens 79-88 25203937-0 2015 Evaluation of Th17-related cytokines and IFNgamma production from blood mononuclear cells of moderate and severe asthmatic children reveals methylprednisolone does not decrease IL-22 levels. Methylprednisolone 140-158 interferon gamma Homo sapiens 41-49 25203937-6 2015 IL-6, IFNgamma, and IL-17A levels were significantly reduced after methylprednisolone treatment (p = 0.02, 0.03, and 0.03, respectively) in Severe Persistent Asthma (SPA) and in Moderate Persistent Asthma (MPA), (p = 0.007, 0.01, and 0.007, respectively). Methylprednisolone 67-85 interferon gamma Homo sapiens 6-14 25203937-8 2015 CONCLUSION: Methylprednisolone downregulated IL-6, IL17A, and IFNgamma, but not IL-22, in stimulated PBMCs from asthmatic children indicating that methylprednisolone has no effect on IL-22 production by PBMCs. Methylprednisolone 12-30 interferon gamma Homo sapiens 62-70 25129514-11 2015 In vitro, IL-33 was upregulated in the nuclei of basal and suprabasal layers by interferon-gamma (IFNgamma), and the upregulation was aggravated by the combination of deoxycholic acid (DCA) and IFNgamma. Deoxycholic Acid 167-183 interferon gamma Homo sapiens 194-202 25129514-11 2015 In vitro, IL-33 was upregulated in the nuclei of basal and suprabasal layers by interferon-gamma (IFNgamma), and the upregulation was aggravated by the combination of deoxycholic acid (DCA) and IFNgamma. Deoxycholic Acid 185-188 interferon gamma Homo sapiens 194-202 25794492-4 2015 The immune activity assay showed 6B11ScFv-mIL-12 to promote proliferation of lymphocytes stimulated by phytohemagglutinin, increase the absolute numbers and percentages of CD3(-)/CD56(+) natural killer cells and CD3(+)/CD56(+) natural killer T cells among peripheral lymphocytes, and increase interferon-gamma. 6b11scfv-mil-12 33-48 interferon gamma Homo sapiens 293-309 25830295-10 2015 Only BcaA and BpaE elicited a strong IFN-gamma response in a restimulation assay using whole blood from seropositive donors and were recognised by seropositive human sera from the endemic area. Amino Acids, Branched-Chain 5-9 interferon gamma Homo sapiens 37-46 25434365-10 2015 Administration of multi-dose parecoxib may diminish the increase in postoperative IL-2, IFN-gamma and IL-17 levels, and suppress the excessive production of IL-4, IL-10 and TGF-beta. parecoxib 29-38 interferon gamma Homo sapiens 88-97 25675966-4 2015 The release of interferon-gamma and IL-2 from human peripheral blood mononuclear cells stimulated by the addition of 30 and 100 mug ml(-1) phytohemagglutinin was significantly inhibited by LCZ at the concentrations of 10(-7) and 10(-6) mol l(-1), respectively. latoconazole 189-192 interferon gamma Homo sapiens 15-31 25830295-10 2015 Only BcaA and BpaE elicited a strong IFN-gamma response in a restimulation assay using whole blood from seropositive donors and were recognised by seropositive human sera from the endemic area. bpae 14-18 interferon gamma Homo sapiens 37-46 25834108-4 2015 In response to interferon-gamma released by activated T cells, these cells produce nitric oxide, which induces allogeneic T cell death both in vitro and in vivo. Nitric Oxide 83-95 interferon gamma Homo sapiens 15-31 25854569-0 2015 [Sodium butyrate down-regulates IFN-gamma-induced indoleamine 2, 3 dioxygenase and promotes its acetylation and ubiquitination in CNE2 nasopharyngeal carcinoma cells]. Butyric Acid 1-16 interferon gamma Homo sapiens 32-41 25854569-1 2015 OBJECTIVE: To investigate molecular mechanisms of posttranslational regulation of sodium butyrate (NaB) on indoleamine 2, 3-dioxygenase (IDO) expression induced by interferon gamma (IFN-gamma) in CNE2 nasopharyngeal carcinoma cells. Butyric Acid 82-97 interferon gamma Homo sapiens 164-191 25854569-1 2015 OBJECTIVE: To investigate molecular mechanisms of posttranslational regulation of sodium butyrate (NaB) on indoleamine 2, 3-dioxygenase (IDO) expression induced by interferon gamma (IFN-gamma) in CNE2 nasopharyngeal carcinoma cells. nab 99-102 interferon gamma Homo sapiens 164-191 25854569-3 2015 RESULTS: Western blotting demonstrated that while the cells were treated with IFN-gamma and NaB compared with IFN-gamma treatment only, the expression of IDO protein increased significantly; furthermore, in the co-immunoprecipitation assay, while the cells were treated with IFN-gamma and NaB compared with the ones treated with IFN-gamma only, acetylation and ubiquitination of IDO increased significantly. nab 92-95 interferon gamma Homo sapiens 110-119 25854569-3 2015 RESULTS: Western blotting demonstrated that while the cells were treated with IFN-gamma and NaB compared with IFN-gamma treatment only, the expression of IDO protein increased significantly; furthermore, in the co-immunoprecipitation assay, while the cells were treated with IFN-gamma and NaB compared with the ones treated with IFN-gamma only, acetylation and ubiquitination of IDO increased significantly. nab 92-95 interferon gamma Homo sapiens 110-119 25854569-3 2015 RESULTS: Western blotting demonstrated that while the cells were treated with IFN-gamma and NaB compared with IFN-gamma treatment only, the expression of IDO protein increased significantly; furthermore, in the co-immunoprecipitation assay, while the cells were treated with IFN-gamma and NaB compared with the ones treated with IFN-gamma only, acetylation and ubiquitination of IDO increased significantly. nab 92-95 interferon gamma Homo sapiens 110-119 25854569-4 2015 Western blotting showed that the cells treated with NaB and IFN-gamma presented with lower IDO protein expression than the ones treated with NaB, IFN-gamma and bortezomib simultaneously. nab 52-55 interferon gamma Homo sapiens 146-155 25854569-4 2015 Western blotting showed that the cells treated with NaB and IFN-gamma presented with lower IDO protein expression than the ones treated with NaB, IFN-gamma and bortezomib simultaneously. nab 141-144 interferon gamma Homo sapiens 60-69 25854569-4 2015 Western blotting showed that the cells treated with NaB and IFN-gamma presented with lower IDO protein expression than the ones treated with NaB, IFN-gamma and bortezomib simultaneously. Bortezomib 160-170 interferon gamma Homo sapiens 60-69 25854569-5 2015 CONCLUSION: NaB could down-regulate the expression of IDO induced by IFN-gamma in a dose-dependent manner, and the combined treatment of IFN-gamma and NaB could promote the acetylation and ubiquitination of IDO in CNE2 nasopharyngeal carcinoma cells. nab 12-15 interferon gamma Homo sapiens 69-78 25948206-9 2015 Serum IL-21 and IFN-gamma levels in ITP patients decreased significantly after HD-DXM administration (P<0.01), while post-treatment levels of IL-4 were increased significantly, compared with the levels before treatment (P<0.01). Dexamethasone 82-85 interferon gamma Homo sapiens 16-25 25792853-5 2015 The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth. Sulfur 80-86 interferon gamma Homo sapiens 142-164 25704249-0 2015 The IFNgamma-PKR pathway in the prefrontal cortex reactions to chronic excessive alcohol use. Alcohols 81-88 interferon gamma Homo sapiens 4-12 25704249-6 2015 CONCLUSIONS: The activation of the IFNgamma-PKR pathway in PFC of humans is associated with chronic excessive ethanol use with an age of onset dependent manner, and activation of this pathway may play a pivotal role in AUD-related brain tissue injury. Ethanol 110-117 interferon gamma Homo sapiens 35-43 25354724-9 2015 Dexamethasone and cyclosporin A significantly reduced IL-17 and IFN-gamma production in PBMCs and dexamethasone up-regulated IL-10 production in activated PBMCs from healthy subjects. Dexamethasone 0-13 interferon gamma Homo sapiens 64-73 25354724-9 2015 Dexamethasone and cyclosporin A significantly reduced IL-17 and IFN-gamma production in PBMCs and dexamethasone up-regulated IL-10 production in activated PBMCs from healthy subjects. Cyclosporine 18-31 interferon gamma Homo sapiens 64-73 25669234-5 2015 Addition of BPH enhanced (p < 0.05) the IFN-gamma reducing capacity of the snack-bar while addition of BPH < 3 and < 5 kDa reduced IL-2 production to a greater extent than unfortified yogurt (p < 0.05). 1-Benzyl-1-phenylhydrazine hydrochloride 12-15 interferon gamma Homo sapiens 43-52 25457208-8 2015 Moreover, ethanol (100 mM) and acetaldehyde (100 and 500 muM) increased levels of IL-6 and IFN-gamma, and suppressed autophagy in VA-13 cells, effects which were markedly alleviated by rapamycin. Ethanol 10-17 interferon gamma Homo sapiens 91-100 25457208-8 2015 Moreover, ethanol (100 mM) and acetaldehyde (100 and 500 muM) increased levels of IL-6 and IFN-gamma, and suppressed autophagy in VA-13 cells, effects which were markedly alleviated by rapamycin. Acetaldehyde 31-43 interferon gamma Homo sapiens 91-100 25457208-8 2015 Moreover, ethanol (100 mM) and acetaldehyde (100 and 500 muM) increased levels of IL-6 and IFN-gamma, and suppressed autophagy in VA-13 cells, effects which were markedly alleviated by rapamycin. Sirolimus 185-194 interferon gamma Homo sapiens 91-100 25343668-0 2015 Retinoic acid modulates interferon-gamma production by hepatic natural killer T cells via phosphatase 2A and the extracellular signal-regulated kinase pathway. Tretinoin 0-13 interferon gamma Homo sapiens 24-40 25343668-7 2015 Our results demonstrated a novel function of RA in modulating the IFN-gamma expression by activated NKT cells. Tretinoin 45-47 interferon gamma Homo sapiens 66-75 25371972-7 2015 IFN-gamma-induced chemokines and IL-13 were found to be notably increased in GaM-treated CTCL cells. gallium maltolate 77-80 interferon gamma Homo sapiens 0-9 25045829-6 2015 Increased serum level of IL-6, IFN-gamma and TNF-alpha was correlated with total bilirubin, ALT, PTA and MELD scores in ACHBLF. Bilirubin 81-90 interferon gamma Homo sapiens 31-40 25092142-5 2015 Functional characterization of LiTAPs by interferon-gamma ELISPOT (Enzyme-Linked ImmunoSpot) and intracellular cytokine staining confirmed AML-specific CD8(+) T-cell recognition. litaps 31-37 interferon gamma Homo sapiens 41-57 25596911-6 2015 The rate of synthesis of NAD and niacin from tryptophan oxidation depends on the induction of the enzyme indoleamine 2,3-dioxygenase (IDO) by pro-inflammatory cytokines such as interferon-gamma. NAD 25-28 interferon gamma Homo sapiens 177-193 25596911-6 2015 The rate of synthesis of NAD and niacin from tryptophan oxidation depends on the induction of the enzyme indoleamine 2,3-dioxygenase (IDO) by pro-inflammatory cytokines such as interferon-gamma. Niacin 33-39 interferon gamma Homo sapiens 177-193 25596911-6 2015 The rate of synthesis of NAD and niacin from tryptophan oxidation depends on the induction of the enzyme indoleamine 2,3-dioxygenase (IDO) by pro-inflammatory cytokines such as interferon-gamma. Tryptophan 45-55 interferon gamma Homo sapiens 177-193 25336517-6 2015 IFNgamma pretreatment enhanced MUC1 expression in MUC1(-) cells and induced sensitivity to MUC1-DTA therapy. diphtheria toxin fragment A 96-99 interferon gamma Homo sapiens 0-8 25584415-5 2015 EGF and BK solely increased Ser-727 and IFN-gamma increased Tyr-705 phosphorylation of STAT-3. Tyrosine 60-63 interferon gamma Homo sapiens 40-49 25584415-12 2015 Thus, EGF-promoted Ser-727 phosphorylation by ERK-1/2 is not only sufficient to fully activate hypothalamic STAT-3, but, in terms of targeted genes and required cofactors, entails distinct modes of STAT-3 actions compared with IFN-gamma-induced Tyr-705 phosphorylation. Serine 19-22 interferon gamma Homo sapiens 227-236 25656974-7 2015 The expression of IL-8 and TNF-alpha was negatively correlated with l-lactate and positively correlated with NH3 and putrescine, whereas the expression of IFN-gamma was positively correlated with histamine and 4-ethylphenol (P< 0 05). Histamine 196-205 interferon gamma Homo sapiens 155-164 25656974-7 2015 The expression of IL-8 and TNF-alpha was negatively correlated with l-lactate and positively correlated with NH3 and putrescine, whereas the expression of IFN-gamma was positively correlated with histamine and 4-ethylphenol (P< 0 05). 4-ethylphenol 210-223 interferon gamma Homo sapiens 155-164 25669986-6 2015 Patients with such pattern of reduction and expansion of Nap-binding T cells also showed increased levels of IL-2 and IFN-gamma in plasma 3 hours after the first Nap treatment. nap 57-60 interferon gamma Homo sapiens 118-127 25189099-4 2015 To enable multiplexing, IFN-gamma and TNF-alpha aptamers were labeled with anthraquinone (AQ) and methylene blue (MB) redox reporters respectively. Anthraquinones 75-88 interferon gamma Homo sapiens 24-33 25767287-5 2015 Cytokines released from these cells, including interleukin-17, interferon-gamma, tumor necrosis factoralpha, and interleukin-6 promote both renal and vascular dysfunction and damage, leading to enhanced sodium retention and increased systemic vascular resistance. Sodium 203-209 interferon gamma Homo sapiens 63-126 25583385-6 2015 The IFN-gamma concentrations were similar in LTBI and aTB children, but appeared to differ qualitatively. atb 54-57 interferon gamma Homo sapiens 4-13 25583385-7 2015 Whereas the IFN-gamma secretion induced by native methylated and recombinant non-methylated HBHA were well correlated for aTB, this was not the case for LTBI children. atb 122-125 interferon gamma Homo sapiens 12-21 25583385-9 2015 The qualitative differences between aTB and LTBI in their HBHA-induced IFN-gamma responses may perhaps be exploited for diagnostic purposes. atb 36-39 interferon gamma Homo sapiens 71-80 25189099-4 2015 To enable multiplexing, IFN-gamma and TNF-alpha aptamers were labeled with anthraquinone (AQ) and methylene blue (MB) redox reporters respectively. Anthraquinones 90-92 interferon gamma Homo sapiens 24-33 25189099-4 2015 To enable multiplexing, IFN-gamma and TNF-alpha aptamers were labeled with anthraquinone (AQ) and methylene blue (MB) redox reporters respectively. Methylene Blue 98-112 interferon gamma Homo sapiens 24-33 25688664-5 2015 Sulfasalazine dose-dependently inhibited tumor necrosis factor alpha, interleukin 1 (IL-1) beta, IL-2, IL-6, interferon gamma (IFNgamma), and various chemotactic cytokines from SEB-stimulated human PBMC. Sulfasalazine 0-13 interferon gamma Homo sapiens 109-125 25688664-5 2015 Sulfasalazine dose-dependently inhibited tumor necrosis factor alpha, interleukin 1 (IL-1) beta, IL-2, IL-6, interferon gamma (IFNgamma), and various chemotactic cytokines from SEB-stimulated human PBMC. Sulfasalazine 0-13 interferon gamma Homo sapiens 127-135 25685909-0 2015 Curcumin and omega-3 fatty acids enhance NK cell-induced apoptosis of pancreatic cancer cells but curcumin inhibits interferon-gamma production: benefits of omega-3 with curcumin against cancer. Curcumin 98-106 interferon gamma Homo sapiens 116-132 25679284-3 2015 We have analyzed the expression level and secretion capacity of IFNgamma from peripheral blood mononuclear cells isolated from five healthy donors and stimulated by calcium ionomycin mixed with phorbol 12-myristate 13-acetate in a non-specific manner in side-by-side testing using ELISPOT, ELISA and flow cytometry assays. calcium ionomycin 165-182 interferon gamma Homo sapiens 64-72 25685909-3 2015 Curcuminoids have bi-functional effects by blocking NFkappaB anti-apoptotic signaling but also blocking anti-oncogenic STAT-1 signaling and interferon-gamma production. curcuminoids 0-12 interferon gamma Homo sapiens 140-156 25685909-6 2015 However, as also shown by others, curcuminoids blocked interferon-gamma production by NK cells. curcuminoids 34-46 interferon gamma Homo sapiens 55-71 25679284-3 2015 We have analyzed the expression level and secretion capacity of IFNgamma from peripheral blood mononuclear cells isolated from five healthy donors and stimulated by calcium ionomycin mixed with phorbol 12-myristate 13-acetate in a non-specific manner in side-by-side testing using ELISPOT, ELISA and flow cytometry assays. Tetradecanoylphorbol Acetate 194-225 interferon gamma Homo sapiens 64-72 25573037-2 2015 Aim of the present study was to evaluate the properties of hydroxyethyl starch nanocapsules (HES-NCs) functionalized with anti-CD40, anti-DEC205, interferon-gamma (IFNgamma) and/or monophosphoryl lipid A (MPLA) with respect to the overall uptake, the released cytokine profile, and the influence on phenotypic maturation of human monocyte-derived DCs using flow cytometry, confocal microscopy and enzyme-linked immunosorbent assays. Hydroxyethyl starch 59-78 interferon gamma Homo sapiens 146-162 25699211-3 2015 High levels or modified forms of cholesterol stimulate release of the inflammatory cytokines IL-12 and IL-18 that synergistically stimulate T lymphocytes to produce the atherogenic cytokine interferon-gamma. Cholesterol 33-44 interferon gamma Homo sapiens 190-206 25673763-8 2015 Further, CD4(+) T cells from SLE patients also exhibited enhanced glycolysis and mitochondrial metabolism that correlated with their activation status, and their excessive IFN-gamma production was significantly reduced by metformin in vitro. Metformin 222-231 interferon gamma Homo sapiens 172-181 25661338-9 2015 The addition of zinc sulphate in vitro to PBMC reduced the IFN-gamma production in the placebo group only. Zinc Sulfate 16-29 interferon gamma Homo sapiens 59-68 25351720-0 2015 N-3 polyunsaturated fatty acids inhibit IFN-gamma-induced IL-18 binding protein production by prostate cancer cells. Fatty Acids, Omega-3 0-31 interferon gamma Homo sapiens 40-49 25585347-4 2015 An evaluation of mast cell activator secretion revealed that IFN-gamma- or IL-4-pretreated HMC-1 cells released dramatically increased levels of beta-hexosaminidase and histamine when stimulated with iopromide. Histamine 169-178 interferon gamma Homo sapiens 61-70 25524770-1 2015 OBJECTIVE: Enhanced tryptophan degradation, induced by the proinflammatory cytokine interferon-gamma, has been related to cardiovascular disease progression and insulin resistance. Tryptophan 20-30 interferon gamma Homo sapiens 84-100 25196646-4 2015 Inhibition of HO-1 via SnMP in cytomegalovirus (CMV)pp65-peptide-pulsed peripheral blood mononuclear cells (PBMCs) led to increased anti-viral T cell activation and the generation of a higher proportion of effector memory T cells (CD45RA(-) CD62L(-)) with increased capability to secrete interferon (IFN)-gamma and granzyme B. tin mesoporphyrin 23-27 interferon gamma Homo sapiens 288-310 25196646-7 2015 Compared to control, SnMP treatment resulted in higher cell counts and purity without negative impact on quality and effector function [CD107a, IFN-gamma and tumour necrosis factor (TNF)-alpha levels were stable]. tin mesoporphyrin 21-25 interferon gamma Homo sapiens 144-153 25484350-6 2015 tBHQ decreased production of the cytokines IL-2 and IFN-gamma at both the protein and mRNA levels after stimulation with anti-CD3/anti-CD28 in human peripheral blood mononuclear cells and to an even greater extent in isolated CD4 T cells. 2-tert-butylhydroquinone 0-4 interferon gamma Homo sapiens 52-61 25585347-4 2015 An evaluation of mast cell activator secretion revealed that IFN-gamma- or IL-4-pretreated HMC-1 cells released dramatically increased levels of beta-hexosaminidase and histamine when stimulated with iopromide. iopromide 200-209 interferon gamma Homo sapiens 61-70 25659387-14 2015 At the same time, secretion of interferon-gamma increased in TGFa induced HSCs, which was decreased by simultaneous addition of simvastatin. Simvastatin 128-139 interferon gamma Homo sapiens 31-47 25359354-7 2015 During isoniazid therapy, a significant increase from baseline in the proportion of IFN-gamma responders to the 10-kDa culture filtrate protein, Rv2031, Rv0849, Rv1986, Rv2659c, Rv2693c and the recombinant Rv1737 protein was observed (p<=0.05). Isoniazid 7-16 interferon gamma Homo sapiens 84-93 25359354-8 2015 The peptide pool of Rv0849 and Rv1737 recombinant proteins induced the highest percentage of IFN-gamma responders after isoniazid therapy. Isoniazid 120-129 interferon gamma Homo sapiens 93-102 24790215-7 2015 IFN-gamma"s effects on relapse were greatly attenuated by immunomodulatory therapies, by summer season and by higher serum vitamin D, whereas TNF-alpha"s inverse association with relapse was only present in these circumstances. Vitamin D 123-132 interferon gamma Homo sapiens 0-9 24790215-9 2015 CONCLUSIONS: We found strong effects of IFN-gamma and TNF-alpha on relapse risk, these differing by immunomodulatory therapy, season, and serum vitamin D, as well as by genotype. Vitamin D 144-153 interferon gamma Homo sapiens 40-49 25408953-5 2015 The CIEF-MS analysis of several variants bearing punctual or deletion mutations within the two D1 and D2 basic clusters at the C-terminal end of IFN-gamma revealed the different contribution of these domains to the charge properties of this heparan sulfate-binding protein. Heparitin Sulfate 241-256 interferon gamma Homo sapiens 145-154 25604685-8 2015 Cultured iPS-RPE cells inhibited cell proliferation and production of IFN-gamma by activated CD4(+) T cells. IPS 9-12 interferon gamma Homo sapiens 70-79 25646096-7 2014 Sensitized T-cells cultured with DC-Exo-treated tumor cells showed a significantly higher percentage of IFN-gamma-secreting cells (as measured by ELISPOT), when compared to the frequency of cells responding to non-DC-Exo-treated cells. dc-exo 33-39 interferon gamma Homo sapiens 104-113 25449698-3 2015 In the present study, we tried to unravel the role of serine proteases in IFN-gamma induced Fas-mediated cell death. ammonium ferrous sulfate 92-95 interferon gamma Homo sapiens 74-83 25499027-9 2015 Chronic alcohol consumption increases the percentage of IFN-gamma-producing iNKT cells and increases the blood concentration of IFN-gamma and IL-12 after in vivo alpha-galactosylceramide (alphaGalCer) stimulation. Alcohols 8-15 interferon gamma Homo sapiens 56-65 25499027-9 2015 Chronic alcohol consumption increases the percentage of IFN-gamma-producing iNKT cells and increases the blood concentration of IFN-gamma and IL-12 after in vivo alpha-galactosylceramide (alphaGalCer) stimulation. Alcohols 8-15 interferon gamma Homo sapiens 128-137 25499027-9 2015 Chronic alcohol consumption increases the percentage of IFN-gamma-producing iNKT cells and increases the blood concentration of IFN-gamma and IL-12 after in vivo alpha-galactosylceramide (alphaGalCer) stimulation. alpha-galactosylceramide 162-186 interferon gamma Homo sapiens 128-137 25949886-10 2015 The IFNgamma-induced gene signature seemed to be enhanced after addition of dacarbazine to sorafenib. Dacarbazine 76-87 interferon gamma Homo sapiens 4-12 25949886-10 2015 The IFNgamma-induced gene signature seemed to be enhanced after addition of dacarbazine to sorafenib. Sorafenib 91-100 interferon gamma Homo sapiens 4-12 25949886-11 2015 Serum IFNgamma also increased during therapy, particularly after addition of dacarbazine. Dacarbazine 77-88 interferon gamma Homo sapiens 6-14 26645326-8 2015 We observed that the CD25 expression exclusively on the CD3(-)CD56(+)CD25(+) NK cells was positively correlated with their cytotoxic function evaluated by the MTT test (r = 0.68), the upregulation of granzyme B (r = 0.89), IL-2 (r = 0.78) and IFN-gamma (r = 0.57), however, it was not positively correlated with FasL and caspase-8. monooxyethylene trimethylolpropane tristearate 159-162 interferon gamma Homo sapiens 243-252 26345342-5 2015 In primary cultured human melanocytes, EGCG pre-treatment attenuated interferon (IFN)-gamma-induced phosphorylation of JAK2 and its downstream signal transducer and activator of transcription (STAT)1 and STAT3 in a dose-dependent manner. epigallocatechin gallate 39-43 interferon gamma Homo sapiens 69-91 26442157-9 2015 IFN-gamma concentrations and IFN-gamma : IL-10 ratio varied significantly with respect to clinical variants, disease stability, and social habits (smoking and alcohol consumption) and showed a positive correlation with disease duration. Alcohols 159-166 interferon gamma Homo sapiens 0-9 26345342-6 2015 We further examined the chemoattractant expression in melanocytes and demonstrated that EGCG significantly inhibited IFN-gamma-induced expression of intracellular adhesion molecule (ICAM)-1, CXCL10, and monocyte chemotactic protein (MCP)-1 in human melanocytes. epigallocatechin gallate 88-92 interferon gamma Homo sapiens 117-126 26345342-8 2015 As a consequence, adhesion of human T cells to melanocytes induced by IFN-gamma was effectively suppressed by EGCG. epigallocatechin gallate 110-114 interferon gamma Homo sapiens 70-79 25815330-7 2015 AA-dependent DEFB1 upregulation below 20 mM predicts in vitro antimicrobial activity as well as glucose- and AA-dependent CAMP and IFNG upregulation. Glucose 96-103 interferon gamma Homo sapiens 131-135 25744452-9 2015 N-Nitro-L-arginine methyl ester, an NO synthase inhibitor, reduced both HO-1 expression and NO production in LPS+IFN-gamma-treated JA-4 cells. n-nitro-l-arginine methyl ester 0-31 interferon gamma Homo sapiens 113-122 25757924-7 2015 In contrast, GJBRH significantly reduced the production of MDC, RANTES, and IL-8 compared with control cells simulated with TNF-alpha and IFN-gamma. gjbrh 13-18 interferon gamma Homo sapiens 138-147 25757924-8 2015 Consistently, GJBRH suppressed the mRNA expression of MDC, RANTES, and IL-8 in TNF-alpha and IFN-gamma-treated cells. gjbrh 14-19 interferon gamma Homo sapiens 93-102 25757924-9 2015 Treatment with GJBRH markedly inhibited phosphorylation of signal transducer and activator of transcription 1 (STAT1) in HaCaT cells stimulated with TNF-alpha and IFN-gamma. gjbrh 15-20 interferon gamma Homo sapiens 163-172 25757924-10 2015 Our findings indicate that GJBRH impairs TNF-alpha and IFN-gamma-mediated inflammatory chemokine production and STAT1 phosphorylation in keratinocytes. gjbrh 27-32 interferon gamma Homo sapiens 55-64 26783516-3 2015 Here, we observed that BA could protect mice from infection by influenza virus A/PR/8/34 (H1N1), associated with increasing IFN-gamma production, but presented no effects in IFN-gamma or IFN-gamma receptor deficient mice. baicalin 23-25 interferon gamma Homo sapiens 124-133 26783516-4 2015 Further study indicated that BA could inhibit A/PR/8/34 replication through IFN-gamma in human PBMC. baicalin 29-31 interferon gamma Homo sapiens 76-85 26783516-5 2015 Moreover, BA can directly induce IFN-gamma production in human CD4(+) and CD8(+) T cells and NK cells, and activate JAK/STAT-1 signaling pathway. baicalin 10-12 interferon gamma Homo sapiens 33-42 25849817-8 2015 Only beta-cryptoxanthin increased IFN-gamma production, suggesting that NK cell activation effects of KP-AF may be caused by carotenoids such as beta-cryptoxanthin. Beta-Cryptoxanthin 5-23 interferon gamma Homo sapiens 34-43 25765663-4 2015 RESULTS: Inflammatory cytokines (TNF-alpha and interferon-gamma) cooperate with bioincompatible PD fluids containing high glucose degradation product (GDP) concentrations to promote mesothelial cell death. Glucose 122-129 interferon gamma Homo sapiens 47-63 25998190-4 2015 METHODS: Phorbol myristate acetate (PMA)-treated THP-1 cells were differentiated to macrophages, which were further polarized to M1 cells by lipopolysaccharide (LPS; 1 microg/ml) and interferon (IFN)-gamma (20 ng/ml) and treated with varying curcumin concentrations. Tetradecanoylphorbol Acetate 9-34 interferon gamma Homo sapiens 183-205 25815330-10 2015 Our results suggest that glucose upregulates CAMP in an IFN-gamma-independent manner. Glucose 25-32 interferon gamma Homo sapiens 56-65 24813229-5 2015 Specifically, zeatin riboside treatment induces the production of cyclic adenosine monophosphate (cAMP) by T lymphocytes and inhibits the production by CD3(+)CD4(+) T cells of interferon (IFN)-gamma, IL-2, tumor-necrosis factor (TNF)-alpha, IL-4 and IL-13, and the production by CD3(+)CD8(+) T cells of IFN-gamma, IL-2 and TNF-alpha. zeatin riboside 14-29 interferon gamma Homo sapiens 176-198 24813229-5 2015 Specifically, zeatin riboside treatment induces the production of cyclic adenosine monophosphate (cAMP) by T lymphocytes and inhibits the production by CD3(+)CD4(+) T cells of interferon (IFN)-gamma, IL-2, tumor-necrosis factor (TNF)-alpha, IL-4 and IL-13, and the production by CD3(+)CD8(+) T cells of IFN-gamma, IL-2 and TNF-alpha. zeatin riboside 14-29 interferon gamma Homo sapiens 303-312 26315837-0 2015 Isoliquiritigenin Inhibits Interferon-gamma-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways. isoliquiritigenin 0-17 interferon gamma Homo sapiens 27-43 26315837-1 2015 BACKGROUND & AIMS: The high expression levels of interferon-gamma (IFN-gamma)-inducible genes correlate positively with liver diseases. Adenosine Monophosphate 12-15 interferon gamma Homo sapiens 53-69 26315837-1 2015 BACKGROUND & AIMS: The high expression levels of interferon-gamma (IFN-gamma)-inducible genes correlate positively with liver diseases. Adenosine Monophosphate 12-15 interferon gamma Homo sapiens 71-80 26315837-2 2015 The present study aimed to explore the effect of isoliquiritigenin (ISL) on the expression of genes induced by IFN-gamma in vitro, and to elucidate the underlying molecular mechanisms. isoliquiritigenin 49-66 interferon gamma Homo sapiens 111-120 25998190-4 2015 METHODS: Phorbol myristate acetate (PMA)-treated THP-1 cells were differentiated to macrophages, which were further polarized to M1 cells by lipopolysaccharide (LPS; 1 microg/ml) and interferon (IFN)-gamma (20 ng/ml) and treated with varying curcumin concentrations. Tetradecanoylphorbol Acetate 36-39 interferon gamma Homo sapiens 183-205 25687700-6 2015 This interferon- gamma-induced astrocytic neurotoxicity is mediated by the activation of the Janus kinase-signal transducer and activator of transcription (STAT) 3 pathway in the astrocytes, and involves intracellular phosphorylation of STAT3 at tyrosine-705 residue. Tyrosine 246-254 interferon gamma Homo sapiens 5-22 26155184-3 2015 Although preliminary studies with CGD patients on treatment with IFN-gamma showed that it enhanced phagocytosis and superoxide production, ongoing studies did not reveal a significant increase of this function. Superoxides 116-126 interferon gamma Homo sapiens 65-74 26155184-11 2015 CONCLUSIONS: Our study showed that IFN-gamma treatment may increase the oxidative bursting activity by increasing the superoxide production in neutrophils, particularly in gp91phox subtype. Superoxides 118-128 interferon gamma Homo sapiens 35-44 26292509-1 2015 We have evaluated the efficacy of cycloferon inclusion in the complex therapy of newly diagnosed patients with common forms of pulmonary tuberculosis, based on monitoring of the number of monocytes with receptors to interferon-gamma (flow cytometry) and the concentration of interferon-gamma in the serum (ELISA). 10-carboxymethyl-9-acridanone 34-44 interferon gamma Homo sapiens 216-232 25048800-11 2015 Protein expression of IL-10 decreased and IFN-gamma increased as the extent of PAH exposure increased. Polycyclic Aromatic Hydrocarbons 79-82 interferon gamma Homo sapiens 42-51 26728736-5 2015 Intranasal administration of Pro-Gly-Pro (PGP) reduced ethanol-induced ulceration, activating the transcription of IFNgamma, IL-2, and IL-4 mRNA in BMNCs and prevents the formation of stress- and acetateinduced ulcers by inhibiting the expression of IL-8 and IL-10 genes, respectively. prolyl-glycyl-proline 29-40 interferon gamma Homo sapiens 115-123 26292509-1 2015 We have evaluated the efficacy of cycloferon inclusion in the complex therapy of newly diagnosed patients with common forms of pulmonary tuberculosis, based on monitoring of the number of monocytes with receptors to interferon-gamma (flow cytometry) and the concentration of interferon-gamma in the serum (ELISA). 10-carboxymethyl-9-acridanone 34-44 interferon gamma Homo sapiens 275-291 26728736-5 2015 Intranasal administration of Pro-Gly-Pro (PGP) reduced ethanol-induced ulceration, activating the transcription of IFNgamma, IL-2, and IL-4 mRNA in BMNCs and prevents the formation of stress- and acetateinduced ulcers by inhibiting the expression of IL-8 and IL-10 genes, respectively. prolyl-glycyl-proline 42-45 interferon gamma Homo sapiens 115-123 26292509-5 2015 The analysis of results showed a statistically significant positive dynamics of the level of monocyte receptors to interferon-gamma in patients receiving cycloferon as manifested by an increase in their number in the first 2 months of therapy (period of clinical manifestations of the disease), followed by a decrease in the 3rd months of treatment, which corresponds to clinical improvement, in contrast to patients treated with standard chemotherapy alone. 10-carboxymethyl-9-acridanone 154-164 interferon gamma Homo sapiens 115-131 26379747-10 2015 In conclusion, we for the first time demonstrated that hinokitiol upregulates p21 expression and attenuates IFN-gamma secretion in ConA-stimulated T lymphocytes, thereby arresting cell cycle at the G0/G1 phase. beta-thujaplicin 55-65 interferon gamma Homo sapiens 108-117 25838833-6 2015 Second, we examined whether BHSST influences the production of chemokines and STAT1 phosphorylation in tumor necrosis factor-alpha/interferon-gamma TI-stimulated HaCaT keratinocytes. bhsst 28-33 interferon gamma Homo sapiens 131-147 25073960-5 2015 We found that amiodarone dose dependently inhibited the production of cytokines, including interleukin-2 (IL-2), IL-4, tumor necrosis factor-alpha, and interferon-gamma in activated human T cells. Amiodarone 14-24 interferon gamma Homo sapiens 152-168 25496023-0 2015 Whether vitamin A supplementation is effective in T-bet and IFN-gamma gene expression reduction? Vitamin A 8-17 interferon gamma Homo sapiens 60-69 25496023-1 2015 BACKGROUND: The aim of present study is evaluation of vitamin A supplementation efficacy on IFN-gamma and T-bet gene expression in atherosclerotic patients. Vitamin A 54-63 interferon gamma Homo sapiens 92-101 25496023-6 2015 RESULTS: IFN-gamma gene expression in fresh cells of patients taking vitamin A declined slightly (0.85-fold, p = 0.068), whereas the expression of this gene was increased in patients taking placebo, and in healthy control subjects 1.2-fold (p = 0.267) and 1.7-fold (p = 0.580), respectively. Vitamin A 69-78 interferon gamma Homo sapiens 9-18 25496023-10 2015 IFN-gamma gene expression in cells activated with ox-LDL in healthy control subjects and patients taking vitamin A, was reduced 0.43 (p = 0.0001) and 0.41 (p = 0.001) respectively, but in placebo patients was increased 2.2-fold (p = 0.959). Vitamin A 105-114 interferon gamma Homo sapiens 0-9 26451144-10 2015 In vivo and in vitro studies showed a downregulation of NGAL, IL-17, IL-6, IL-1beta, TNF-alpha, and IFN-gamma after paricalcitol administration (p < 0.0001). paricalcitol 116-128 interferon gamma Homo sapiens 100-109 25740578-7 2015 Atorvastatin treatment increased the percentage and inhibitory ability of nTregs, decreased serum IFN-gamma and hsCRP levels, and decreased IL-10 and TGF-beta1 levels, as compared with the non-atorvastatin group.Our findings suggest that nTregs play an atheroprotective role in atherosclerosis. Atorvastatin 0-12 interferon gamma Homo sapiens 98-107 26398897-7 2015 In lipopolysaccharide (LPS)-stimulated PBMCs, SCFAs particularly butyrate down-regulated tumor necrosis factor alpha, interleukin (IL)-12, interferon gamma (IFN-gamma) and transforming growth factor beta-1 (TGF-beta1), and up-regulated IL-4, IL-10, while no significant effect was noted in non-LPS-stimulated PBMCs. Fatty Acids, Volatile 46-51 interferon gamma Homo sapiens 139-166 26398897-7 2015 In lipopolysaccharide (LPS)-stimulated PBMCs, SCFAs particularly butyrate down-regulated tumor necrosis factor alpha, interleukin (IL)-12, interferon gamma (IFN-gamma) and transforming growth factor beta-1 (TGF-beta1), and up-regulated IL-4, IL-10, while no significant effect was noted in non-LPS-stimulated PBMCs. Butyrates 65-73 interferon gamma Homo sapiens 139-166 24806275-2 2015 The goal of this study was to investigate the potential for Mn(2+), via its pro-oxidative properties, to activate production of pro-inflammatory cytokines/chemokines IL-1beta, IL-6, IL-8, IFNgamma, TNFalpha, and G-CSF by human monocyte-derived macrophages in vitro. Manganese(2+) 60-66 interferon gamma Homo sapiens 188-196 25720398-9 2015 Granzyme B expression and cytokine production (TNFalpha, IFNgamma) were increased in aMCI but not in mAD. amci 85-89 interferon gamma Homo sapiens 57-65 25738401-8 2015 When extrapolating the in vitro results to in vivo, IFN-gamma-mediated breakdown of tryptophan could be counteracted by the consumption of coffee or decaffeinated coffee. Tryptophan 84-94 interferon gamma Homo sapiens 52-61 24806275-5 2015 Exposure of the cells to LPS caused modest statistically insignificant increases in cytokine production; MnCl2 caused dose-related increases in production of all six cytokines (achieving statistical significance of p < 0.0171- < 0.0005 for IL-1beta, IL-6, IL-8, IFNgamma, and TNFalpha). manganese chloride 105-110 interferon gamma Homo sapiens 268-276 24806275-6 2015 In the case of LPS and MnCl2 combinations, the observed increases in production of IL-1beta, IL-6, IL-8, IFNgamma, and G-CSF were greater than those seen with cells exposed to the individual agents. manganese chloride 23-28 interferon gamma Homo sapiens 105-113 25815345-9 2015 When pulsed with leukemic lysates and matured with PGE2, DCs are impaired in the induction of IFN-gamma secreting CD4(+) and CD8(+) T cells due to IDO1 upregulation. Dinoprostone 51-55 interferon gamma Homo sapiens 94-103 25480564-5 2015 We found an increased ratio of IFN-gamma/IL-17 expression in Th17 cells in children with advanced beta cell autoimmunity, which correlated with HbA1c and plasma glucose concentrations in an oral glucose tolerance test, and thus impaired beta cell function. Glucose 161-168 interferon gamma Homo sapiens 31-40 25480564-5 2015 We found an increased ratio of IFN-gamma/IL-17 expression in Th17 cells in children with advanced beta cell autoimmunity, which correlated with HbA1c and plasma glucose concentrations in an oral glucose tolerance test, and thus impaired beta cell function. Glucose 195-202 interferon gamma Homo sapiens 31-40 25626534-7 2015 When IFN-gamma binds to the aptamer, it triggers the release of a reporter enzyme, invertase, which can catalyze the conversion of sucrose (not detected by BGM) to glucose. Sucrose 131-138 interferon gamma Homo sapiens 5-14 26347897-8 2015 LAM-exposed monocytes generated macrophages that were less efficient in producing proinflammatory cytokines such as TNF-alpha and IFN-gamma; however, their phagocytic capacity was not modified. lipoarabinomannan 0-3 interferon gamma Homo sapiens 130-139 25626534-7 2015 When IFN-gamma binds to the aptamer, it triggers the release of a reporter enzyme, invertase, which can catalyze the conversion of sucrose (not detected by BGM) to glucose. Glucose 164-171 interferon gamma Homo sapiens 5-14 25322862-5 2015 Changes in the sensitivity of melanoma cells to IFN-gamma were detected using an MTT assay. monooxyethylene trimethylolpropane tristearate 81-84 interferon gamma Homo sapiens 48-57 26111958-5 2015 RESULTS: Significantly higher plasma levels of IL-12p70, IL-23, IL-27, IFN-gamma and IL-17A were observed in cITP patients than in controls (p < 0.01), and after HD-DXM treatment, these levels decreased significantly (p < 0.01). citp 109-113 interferon gamma Homo sapiens 71-80 25169677-10 2015 Pretreatment of LPS/IFNgamma-stimulated human microglia cells with the nonsteroidal anti-inflammatory drugs ibuprofen and aspirin, the antioxidant GSH, the H2S donor NaSH, and the anti-inflammatory cytokine IL-10, resulted in a CM with diminished ability to stimulate tau expression. Ibuprofen 108-117 interferon gamma Homo sapiens 20-28 25332239-8 2015 This ninein-dependent inhibition of JAK2 significantly decreases prolactin- and interferon gamma (IFN-gamma)-induced tyrosyl phosphorylation of STAT1 and STAT5. cyclo(tyrosyl-tyrosyl) 117-124 interferon gamma Homo sapiens 80-107 25169677-10 2015 Pretreatment of LPS/IFNgamma-stimulated human microglia cells with the nonsteroidal anti-inflammatory drugs ibuprofen and aspirin, the antioxidant GSH, the H2S donor NaSH, and the anti-inflammatory cytokine IL-10, resulted in a CM with diminished ability to stimulate tau expression. Aspirin 122-129 interferon gamma Homo sapiens 20-28 25169677-10 2015 Pretreatment of LPS/IFNgamma-stimulated human microglia cells with the nonsteroidal anti-inflammatory drugs ibuprofen and aspirin, the antioxidant GSH, the H2S donor NaSH, and the anti-inflammatory cytokine IL-10, resulted in a CM with diminished ability to stimulate tau expression. Glutathione 147-150 interferon gamma Homo sapiens 20-28 25169677-10 2015 Pretreatment of LPS/IFNgamma-stimulated human microglia cells with the nonsteroidal anti-inflammatory drugs ibuprofen and aspirin, the antioxidant GSH, the H2S donor NaSH, and the anti-inflammatory cytokine IL-10, resulted in a CM with diminished ability to stimulate tau expression. Deuterium 156-159 interferon gamma Homo sapiens 20-28 26513451-8 2015 However, the present studies also show that epithelial cells produce increased amounts of reactive oxygen species during stimulation with tumor necrosis factor-alpha and interferon-gamma resulting in DNA instability. Reactive Oxygen Species 90-113 interferon gamma Homo sapiens 170-186 25626322-3 2015 Lenalidomide stimulates T cells and NK-cell through production of Th1 type cytokines IL-2 and IFN-gamma from CD4+ helper-T cells. Lenalidomide 0-12 interferon gamma Homo sapiens 94-103 25186311-2 2015 Using microarray expression analysis, we found that IFNgamma upregulates a set of genes associated with a tryptophan degradation pathway, known as the kynurenine pathway, in osteogenic differentiating human mesenchymal stem cells (hMSC). Tryptophan 106-116 interferon gamma Homo sapiens 52-60 25186311-2 2015 Using microarray expression analysis, we found that IFNgamma upregulates a set of genes associated with a tryptophan degradation pathway, known as the kynurenine pathway, in osteogenic differentiating human mesenchymal stem cells (hMSC). Kynurenine 151-161 interferon gamma Homo sapiens 52-60 26124839-8 2015 ATRA-pretreated MSCs significantly decreased not only the vital pathogenic cytokine in AS, tumor necrosis factor-alpha (TNF-alpha), but also AS-boosting factors interleukin-17 (IL-17A) and interferon-gamma (IFN-gamma). Tretinoin 0-4 interferon gamma Homo sapiens 189-205 25065014-5 2015 We aimed to assess the in vitro effects of IFN-gamma-pretreated microencapsulated (CpS)-hUCMS on T cells of pSS. pss 108-111 interferon gamma Homo sapiens 43-52 26124839-8 2015 ATRA-pretreated MSCs significantly decreased not only the vital pathogenic cytokine in AS, tumor necrosis factor-alpha (TNF-alpha), but also AS-boosting factors interleukin-17 (IL-17A) and interferon-gamma (IFN-gamma). Tretinoin 0-4 interferon gamma Homo sapiens 207-216 25331710-7 2014 A significant negative correlation was also observed between 25-hydroxyvitamin D concentration and circulating concentrations of IL-1beta (r -0.323; P<= 0.001) as well as IL-6 (r -0.154; P<= 0.04), but not between 25-hydroxyvitamin D and TNF-alpha and IFN-gamma concentrations. 25-hydroxyvitamin D 61-80 interferon gamma Homo sapiens 258-267 25584044-9 2014 Indeed, we found that inhibition of PGE2 production by MSCs could also significantly restore IFN-gamma production. Dinoprostone 36-40 interferon gamma Homo sapiens 93-102 25517939-0 2014 Genkwadaphnin induces IFN-gamma via PKD1/NF-kappaB/STAT1 dependent pathway in NK-92 cells. genkwadaphnin 0-13 interferon gamma Homo sapiens 22-31 25517939-7 2014 GD-1 effect on IFN-gamma production was blocked by the addition of Rottlerin, a PKC inhibitor, CID 755673, a PKD inhibitor, or Bay11-7082, an IKKalpha inhibitor. rottlerin 67-76 interferon gamma Homo sapiens 15-24 25517939-7 2014 GD-1 effect on IFN-gamma production was blocked by the addition of Rottlerin, a PKC inhibitor, CID 755673, a PKD inhibitor, or Bay11-7082, an IKKalpha inhibitor. 3-(4-methylphenylsulfonyl)-2-propenenitrile 127-137 interferon gamma Homo sapiens 15-24 25453808-3 2014 Incorporation of amino group to 3-position of the cyclopentane ring resulted in a series of JAK3 inhibitors (4g-4j) that potently inhibited IFNgamma production in an IL2-induced whole blood assay and displayed high functional selectivity for JAK3-JAK1 pathway relative to JAK2. Cyclopentanes 50-62 interferon gamma Homo sapiens 140-148 25526807-1 2014 BACKGROUND: A shift between two dimer conformations has been proposed for the transcription factor STAT1 (signal transducer and activator of transcription 1) which links DNA binding of the parallel dimer to tyrosine dephosphorylation of the antiparallel dimer as two consecutive and important steps in interferon- gamma (IFNgamma)-mediated signalling. Tyrosine 207-215 interferon gamma Homo sapiens 302-319 25526807-1 2014 BACKGROUND: A shift between two dimer conformations has been proposed for the transcription factor STAT1 (signal transducer and activator of transcription 1) which links DNA binding of the parallel dimer to tyrosine dephosphorylation of the antiparallel dimer as two consecutive and important steps in interferon- gamma (IFNgamma)-mediated signalling. Tyrosine 207-215 interferon gamma Homo sapiens 321-329 25493648-3 2014 Recent animal studies have demonstrated that IFN-gamma induces loss of dopamine neurons and nigrostriatal degeneration. Dopamine 71-79 interferon gamma Homo sapiens 45-54 25454870-9 2014 This was accompanied by a significant reduction in expression of CD38 on CD4 T cells (p=0.0194), significantly increased IFN-gamma and IL-2 production in response to Gag (p=0.0122) and elevated IFN-gamma production in response to Tat (p=0.041) at week 48 compared to baseline. Glycosaminoglycans 166-169 interferon gamma Homo sapiens 121-130 25331548-0 2014 Lactose inhibits regulatory T-cell-mediated suppression of effector T-cell interferon-gamma and IL-17 production. Lactose 0-7 interferon gamma Homo sapiens 75-91 25331548-6 2014 Treg and Teff at a ratio 1:5 were activated and the effects of lactose on the secretion of interferon-gamma (IFN-gamma) and IL-17 were analysed using ELISA for protein and quantitative RT-PCR for mRNA. Lactose 63-70 interferon gamma Homo sapiens 91-107 25331548-6 2014 Treg and Teff at a ratio 1:5 were activated and the effects of lactose on the secretion of interferon-gamma (IFN-gamma) and IL-17 were analysed using ELISA for protein and quantitative RT-PCR for mRNA. Lactose 63-70 interferon gamma Homo sapiens 109-118 25474109-7 2014 Thus, our results identify IL-1 and IFN-gamma as regulators of DC programming by beta-glucan. beta-Glucans 81-92 interferon gamma Homo sapiens 36-45 25331954-5 2014 The PAR2 agonists 2-furoyl-LIGRLO (2f-LI), SLIGKV and trypsin all significantly reduced cleavage of caspase-3, -8, and -9, poly(ADP-ribose) polymerase, and the externalization of phosphatidylserine after treatment of cells with IFN-gamma and TNF-alpha. 2-furoyl 18-26 interferon gamma Homo sapiens 228-237 25941601-5 2014 The highest frequencies of IFNgamma or granzyme B producing cells were detected within CM XBP1-CTL subset that were either Tbet+ or Eomes+ in responding to the tumor cells.These results demonstrate the immunotherapeutic potential of a cocktail of immunogenic HLA-A2 specific heteroclitic XBP1 US184-192 and heteroclictic XBP1 SP367-375 peptides to induce CD3+CD8+ CTL enriched for CM and EM cells with specific antitumor activities against a variety of solid tumors. tbet 123-127 interferon gamma Homo sapiens 27-35 25022448-9 2014 In conclusion, polymorphisms in IL6, TNF, IL10, IL17A and IFNG are associated with susceptibility to cSSSIs. csssis 101-107 interferon gamma Homo sapiens 58-62 25409241-6 2014 The AT and TT genotypes of IFN-gamma and GG genotype of IL-6 were found to be significantly associated with CIU. n-cyclohexyl-n'-(4-iodophenyl)urea 108-111 interferon gamma Homo sapiens 27-36 25409241-8 2014 In addition to this, association studies have revealed that TT genotype of IFN-gamma +874 T/A and GG genotype of IL-6-174 G/C were susceptible towards the CIU. n-cyclohexyl-n'-(4-iodophenyl)urea 155-158 interferon gamma Homo sapiens 75-84 25454621-8 2014 Furthermore, in BeS and CBD subjects, SB203580 downregulated Be-stimulated proliferation in a dose-dependent manner, and decreased Be-stimulated TNF-alpha and IFNgamma cytokine production. SB 203580 38-46 interferon gamma Homo sapiens 159-167 25261409-0 2014 Epigallocatechin-3-gallate sensitizes IFN-gamma-stimulated CD4+ T cells to apoptosis via alternative activation of STAT1. epigallocatechin gallate 0-26 interferon gamma Homo sapiens 38-47 25261409-6 2014 Interestingly, EGCG promoted apoptosis of CD4(+) T cells treated with IFN-gamma. epigallocatechin gallate 15-19 interferon gamma Homo sapiens 70-79 25261409-7 2014 The increases in STAT1 activation and apoptosis induced by EGCG in IFN-gamma-activated CD4(+) T cells were almost completely abolished by a selective Src family kinase inhibitor, SU6656. epigallocatechin gallate 59-63 interferon gamma Homo sapiens 67-76 25261409-7 2014 The increases in STAT1 activation and apoptosis induced by EGCG in IFN-gamma-activated CD4(+) T cells were almost completely abolished by a selective Src family kinase inhibitor, SU6656. SU 6656 179-185 interferon gamma Homo sapiens 67-76 25261409-9 2014 In conclusion, the present study reports an alternative activation of STAT1 via Src by EGCG in IFN-gamma-activated CD4(+) T cells, which promotes the apoptosis of IFN-gamma-activated CD4(+) T cells and contributes to the improvement of T cell-mediated colitis. epigallocatechin gallate 87-91 interferon gamma Homo sapiens 95-104 25261409-9 2014 In conclusion, the present study reports an alternative activation of STAT1 via Src by EGCG in IFN-gamma-activated CD4(+) T cells, which promotes the apoptosis of IFN-gamma-activated CD4(+) T cells and contributes to the improvement of T cell-mediated colitis. epigallocatechin gallate 87-91 interferon gamma Homo sapiens 163-172 25261409-10 2014 Our findings suggest a novel role of EGCG in regulating IFN-gamma signaling and controlling inflammation. epigallocatechin gallate 37-41 interferon gamma Homo sapiens 56-65 25445961-0 2014 Iminosugar derivative WGN-26 suppresses acute allograft rejection via inhibiting the IFN-gamma/p-STAT1/T-bet signaling pathway. Imino Sugars 0-10 interferon gamma Homo sapiens 85-94 25466265-6 2014 RESULTS: Dexamethasone caused variable inhibition of cytokines; 1 muM inhibited IL-10 and IL-17 by 50% or lower, while inhibition > 50% was observed for IL-2, IL-13 and IFNgamma. Dexamethasone 9-22 interferon gamma Homo sapiens 172-180 24916315-4 2014 Mechanism studies revealed that T cell-derived IFN-gamma and CD40 ligand (CD40L) induced the expression of indoleamine 2,3-dioxygenase (IDO) in OCs, which mediated the immunosuppressive function on T-cell proliferation through depleting tryptophan. Tryptophan 237-247 interferon gamma Homo sapiens 47-56 25114162-6 2014 HMBPP-deficient listeria differentiated fewer Vgamma2Vdelta2 T effector cells capable of coproducing IFN-gamma and TNF-alpha and inhibiting intracellular listeria than HMBPP-producing listeria. 4-hydroxy-3-methylbut-2-enyl pyrophosphate 0-5 interferon gamma Homo sapiens 101-110 25297574-2 2014 First of all, IFN-gamma sensitized cells to the neurotoxin MPP(+), as determined by MTT (3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide) assay. 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide 89-149 interferon gamma Homo sapiens 14-23 25449852-5 2014 Circulating Th1, Th2 and Th17 effector cells were identified by intracellular staining for IFN-gamma, IL-4 and IL-17, respectively, upon in vitro stimulation with PMA and calcium ionophore. Tetradecanoylphorbol Acetate 163-166 interferon gamma Homo sapiens 91-100 25297574-2 2014 First of all, IFN-gamma sensitized cells to the neurotoxin MPP(+), as determined by MTT (3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide) assay. monooxyethylene trimethylolpropane tristearate 84-87 interferon gamma Homo sapiens 14-23 25297574-5 2014 L-NAME [N(omega)-nitro-L-arginine methyl ester, a non-specific NOS inhibitor] reestablished the cell viability after IFN-gamma challenging, and recovered cells from MPP(+) injury (95.0 vs. 84.7 %; P < 0.05). NG-Nitroarginine Methyl Ester 0-6 interferon gamma Homo sapiens 117-126 25297574-5 2014 L-NAME [N(omega)-nitro-L-arginine methyl ester, a non-specific NOS inhibitor] reestablished the cell viability after IFN-gamma challenging, and recovered cells from MPP(+) injury (95.0 vs. 84.7 %; P < 0.05). NG-Nitroarginine Methyl Ester 8-46 interferon gamma Homo sapiens 117-126 25297574-6 2014 Seven-NI (7-nitroindazole, a nNOS inhibitor) protected cells against the injury by MPP(+) co-administered with IFN-gamma. 7-nitroindazole 10-25 interferon gamma Homo sapiens 111-120 25297574-9 2014 Indeed, L-NAME was more effective than 7-NI for reducing oxidative stress caused by MPP(+) under IFN-gamma exposition. NG-Nitroarginine Methyl Ester 8-14 interferon gamma Homo sapiens 97-106 25297574-9 2014 Indeed, L-NAME was more effective than 7-NI for reducing oxidative stress caused by MPP(+) under IFN-gamma exposition. 7-nitroindazole 39-43 interferon gamma Homo sapiens 97-106 25297574-11 2014 In conclusion, IFN-gamma sensitizes cells to MPP(+)-induced injury, also causing an increase in ROS levels. Reactive Oxygen Species 96-99 interferon gamma Homo sapiens 15-24 25135357-2 2014 At molecular level, GSNO effects have been shown to modulate the activity of a series of transcription factors (notably NF-kappaB, AP-1, CREB and others) as well as other components of signal transduction chains (e.g. IKK-beta, caspase 1, calpain and others), resulting in the modulation of several cytokines and chemokines expression (TNFalpha, IL-1beta, IFN-gamma, IL-4, IL-8, RANTES, MCP-1 and others). S-Nitrosoglutathione 20-24 interferon gamma Homo sapiens 356-365 25192396-8 2014 We and others have reported markedly reduced interferon-gamma production by neonate mononuclear cells exposed to GBS. gbs 113-116 interferon gamma Homo sapiens 45-61 25072865-0 2014 A key role of the mitochondrial citrate carrier (SLC25A1) in TNFalpha- and IFNgamma-triggered inflammation. Citric Acid 32-39 interferon gamma Homo sapiens 75-83 25407340-9 2014 RESULTS: In peripheral blood mononuclear cells (PBMCs) derived from GOS-treated foals at day 28, a standardized lipopolysaccharide challenge resulted in significantly lower relative mRNA expression levels of the pro-inflammatory cytokines interferon-gamma and interleukin-6 compared with PBMCs of control foals. D-Glucitol-1,6-bisphosphate 68-71 interferon gamma Homo sapiens 239-255 25072865-5 2014 By studying the down-stream events following SLC25A1 activation during signals that mimic inflammation, we demonstrate that CIC is required for regulating the levels of nitric oxide and of prostaglandins by TNFalpha or IFNgamma. Nitric Oxide 169-181 interferon gamma Homo sapiens 219-227 25072865-5 2014 By studying the down-stream events following SLC25A1 activation during signals that mimic inflammation, we demonstrate that CIC is required for regulating the levels of nitric oxide and of prostaglandins by TNFalpha or IFNgamma. Prostaglandins 189-203 interferon gamma Homo sapiens 219-227 24948355-1 2014 BACKGROUND: It has been reported that interferon-gamma (IFN-gamma)-induced inflammatory markers, such as circulating neopterin and kynurenine-to-tryptophan ratio (KTR), are increased in patients with cancer and are also a predictor of poor prognosis. Neopterin 117-126 interferon gamma Homo sapiens 38-65 25072865-6 2014 Importantly, we show that the citrate exported from mitochondria via CIC and its downstream metabolic intermediate, acetyl-coenzyme A, are necessary for TNFalpha or IFNgamma to induce nitric oxide and prostaglandin production. Citric Acid 30-37 interferon gamma Homo sapiens 165-173 25072865-6 2014 Importantly, we show that the citrate exported from mitochondria via CIC and its downstream metabolic intermediate, acetyl-coenzyme A, are necessary for TNFalpha or IFNgamma to induce nitric oxide and prostaglandin production. Nitric Oxide 184-196 interferon gamma Homo sapiens 165-173 25072865-6 2014 Importantly, we show that the citrate exported from mitochondria via CIC and its downstream metabolic intermediate, acetyl-coenzyme A, are necessary for TNFalpha or IFNgamma to induce nitric oxide and prostaglandin production. Prostaglandins 201-214 interferon gamma Homo sapiens 165-173 24948355-1 2014 BACKGROUND: It has been reported that interferon-gamma (IFN-gamma)-induced inflammatory markers, such as circulating neopterin and kynurenine-to-tryptophan ratio (KTR), are increased in patients with cancer and are also a predictor of poor prognosis. kynurenine-to-tryptophan 131-155 interferon gamma Homo sapiens 38-65 24962673-7 2014 Cells producing IL-17 and interferon (IFN)-gamma after stimulation with mKatG were enumerated by enzyme-linked immunospot (ELISPOT). mkatg 72-77 interferon gamma Homo sapiens 26-48 24668555-4 2014 Vitamin D inhibits IFN-gamma and IL-17 production while inducing regulatory T cells. Vitamin D 0-9 interferon gamma Homo sapiens 19-28 25568671-3 2014 Doxazosin induces dose-dependent growth suppression and is additively activated through IFN-alpha or IFN-gamma stimulation. Doxazosin 0-9 interferon gamma Homo sapiens 101-110 25135878-5 2014 Results showed that Ub-HBcAg-CTP increased the anti-HBcAg titer and produced the cytokines IFN-gamma and IL-2. hbcag-ctp 23-32 interferon gamma Homo sapiens 91-100 25340519-6 2014 Exposure of cells to T. cruzi trypomastigotes in the absence of IFNgamma resulted in both sustained tyrosine and serine phosphorylation of STAT1 and its increased DNA binding. Tyrosine 100-108 interferon gamma Homo sapiens 64-72 25568671-9 2014 Our data indicate that doxazosin can modulate the apoptotic effects of IFN-alpha- and IFN-gamma through the JAK/STAT signaling pathways. Doxazosin 23-32 interferon gamma Homo sapiens 86-95 24831467-0 2014 IFN-gamma and TNF-alpha are involved during Alzheimer disease progression and correlate with nitric oxide production: a study in Algerian patients. Nitric Oxide 93-105 interferon gamma Homo sapiens 0-9 24936834-6 2014 Ligation of DC-HIL transduced phosphorylation of its intracellular immunoreceptor tyrosine-based activation motif, which in turn induced intracellular expression of IFN-gamma and inducible nitric oxide synthase (iNOS), known to mediate T-cell suppression by CD11b(+)Gr1(+) cells. Tyrosine 82-90 interferon gamma Homo sapiens 165-174 25238642-5 2014 Moreover, rIL-2--unlike rIL-12 or DGKalpha-i--increased the frequencies of RV-CD4 TNF-alpha(+), CD4 IFN-gamma(+), and CD8 IFN-gamma(+) cells. Cephradine 10-13 interferon gamma Homo sapiens 100-109 25238642-5 2014 Moreover, rIL-2--unlike rIL-12 or DGKalpha-i--increased the frequencies of RV-CD4 TNF-alpha(+), CD4 IFN-gamma(+), and CD8 IFN-gamma(+) cells. Cephradine 10-13 interferon gamma Homo sapiens 122-131 25360821-6 2014 Transfection of miR-30a-3p antisense in Poly(I:C)- and IFN-gamma-activated NFLS and NHDF upregulated BAFF secretion, confirming that this microRNA is a basal repressors of BAFF expression in cells from healthy donors. nhdf 84-88 interferon gamma Homo sapiens 55-64 25236584-9 2014 Strikingly, in contrast to the population of IL-10-producing Treg cells induced by calcitriol-primed DCs, the IL-10-producing Treg cells induced by calcidiol-primed DCs exhibited sustained IFN-gamma production in face of their suppressive capacity. Calcifediol 148-157 interferon gamma Homo sapiens 189-198 25340519-6 2014 Exposure of cells to T. cruzi trypomastigotes in the absence of IFNgamma resulted in both sustained tyrosine and serine phosphorylation of STAT1 and its increased DNA binding. Serine 113-119 interferon gamma Homo sapiens 64-72 25180249-3 2014 5-fluoroisatin was used to non-invasively detect ONOO(-) formation in living lung epithelial cells stimulated with interferon-gamma (IFN-gamma). 5-Fluoroisatin 0-14 interferon gamma Homo sapiens 115-131 25180249-3 2014 5-fluoroisatin was used to non-invasively detect ONOO(-) formation in living lung epithelial cells stimulated with interferon-gamma (IFN-gamma). 5-Fluoroisatin 0-14 interferon gamma Homo sapiens 133-142 25180249-3 2014 5-fluoroisatin was used to non-invasively detect ONOO(-) formation in living lung epithelial cells stimulated with interferon-gamma (IFN-gamma). onoo( 49-54 interferon gamma Homo sapiens 115-131 25180249-3 2014 5-fluoroisatin was used to non-invasively detect ONOO(-) formation in living lung epithelial cells stimulated with interferon-gamma (IFN-gamma). onoo( 49-54 interferon gamma Homo sapiens 133-142 25218635-3 2014 Simplexin, a daphnane diterpene ester, was identified for the first time from this genus and caused an increase in the production of cytokines (IFNgamma, IL1beta, IL6, and IL13) by peripheral blood mononuclear cells. simplexin 0-9 interferon gamma Homo sapiens 144-152 24837962-4 2014 The presence of UF of EVOO promoted apoptosis and attenuated activation of intestinal and blood T cells isolated from IBD patients, decreasing the frequency of CD69(+) and CD25(+) T cells and, also, the secretion of IFN-gamma. evoo 22-26 interferon gamma Homo sapiens 216-225 25293882-4 2014 Recent data suggest a link between the tryptophan oxidation pathway, immune activation and HIV disease progression based on overstimulation of the tryptophan oxidation pathway by HIV antigens and by interferon-gamma. Tryptophan 39-49 interferon gamma Homo sapiens 199-215 25379383-6 2014 Like STAT1, ectopically expressed STAT2a and b were shown to be tyrosine phosphorylated by type I IFNs and, interestingly, also by IFNgamma. Tyrosine 64-72 interferon gamma Homo sapiens 131-139 25279717-4 2014 Also, 1,25(OH)2D3 and TX527 treatment inhibit the production of effector cytokines IFN-gamma, IL-9, and IL-17. Calcitriol 6-17 interferon gamma Homo sapiens 83-92 25279717-4 2014 Also, 1,25(OH)2D3 and TX527 treatment inhibit the production of effector cytokines IFN-gamma, IL-9, and IL-17. inecalcitol 22-27 interferon gamma Homo sapiens 83-92 25023628-7 2014 This critical ability of poly(I:C)-matured moDCs to provide IL12p70 to developing KIRnegNKG2Aneg precursors results in a dom4inant, multifunctional, NKG2Apos NK-cell population that is capable of both cytolysis and IFNgamma production. poly 25-29 interferon gamma Homo sapiens 215-223 24894428-9 2014 Cancer cells released soluble factors that inhibited granzyme B, perforin and IFN-gamma production that was partially associated with the PGE2 /COX2 pathway. Dinoprostone 138-142 interferon gamma Homo sapiens 78-87 25023628-7 2014 This critical ability of poly(I:C)-matured moDCs to provide IL12p70 to developing KIRnegNKG2Aneg precursors results in a dom4inant, multifunctional, NKG2Apos NK-cell population that is capable of both cytolysis and IFNgamma production. Iodine 30-31 interferon gamma Homo sapiens 215-223 25123411-5 2014 To show proof of concept, human peripheral blood mononuclear cells were stimulated with phorbol 12-myristate 13-acetate and ionomycin for a maximum of 5 h, during which their CD4 and interferon-gamma (IFN-gamma) transcript and protein levels were monitored. Tetradecanoylphorbol Acetate 88-119 interferon gamma Homo sapiens 201-210 25109693-12 2014 IFN-gamma correlated positively with T-regs but negatively with IL-1beta (P = 0.041&0.046 respectively), which correlated positively with T-effs%( P = 0.05). Adenosine Monophosphate 84-87 interferon gamma Homo sapiens 0-9 30011685-4 2014 They showed a clear IFN-gamma inducing activity in human PBMCs, which suggests these polysaccharides to have proinflammatory effects. Polysaccharides 85-100 interferon gamma Homo sapiens 20-29 30011685-5 2014 Treatment by beta-glucosidase caused the polysaccharides to be degraded into smaller fragments and at the same time increased their IFN-gamma inducing activity in PBMCs fourfold. Polysaccharides 41-56 interferon gamma Homo sapiens 132-141 24700342-6 2014 During RBV pretreatment, both the frequency of CD56(dim) NK cells with cytotoxic effector functions and the frequency of CD56(bright) NK cells with the capacity to produce IFN-gamma decreased (P = 0.049 and P = 0.001, respectively). Ribavirin 7-10 interferon gamma Homo sapiens 172-181 24700342-10 2014 CONCLUSION: RBV enhances the pSTAT4 and IFN-gamma response of NK cells to IFN-alpha-stimulation. Ribavirin 12-15 interferon gamma Homo sapiens 40-49 24954891-3 2014 We show in response to activation with IFN-gamma (IFN-gamma) and lipopolysaccharide (LPS), that the Sp-MPhi readily acquired an M1 status indicated by up-regulation of iNOS mRNA, nitric oxide (NO) production, and the co-stimulatory molecule CD86. Nitric Oxide 179-191 interferon gamma Homo sapiens 50-59 24981709-2 2014 miR-29 was recently shown to non-redundantly inhibit IFN-gamma. mir-29 0-6 interferon gamma Homo sapiens 53-62 25042796-0 2014 Interferon gamma induced by resveratrol analog, HS-1793, reverses the properties of tumor associated macrophages. Resveratrol 28-39 interferon gamma Homo sapiens 0-16 25042796-4 2014 As these results suggested that IFN-gamma increased locally at the tumor sites could modulate the status of TAM, we designed an in vitro model to study macrophage morphology and functions in relation to the tumor microenvironment. tam 108-111 interferon gamma Homo sapiens 32-41 25107440-9 2014 DTC models showed the relative importance of various cytokines such as IFN-gamma, TNF-alpha and IL-10 to CRS. dtc 0-3 interferon gamma Homo sapiens 71-80 25109413-9 2014 Ex-vivo whole blood assay demonstrated prolonged pharmacological activity of GSK1070806 as determined by its primary immunological mechanism of action, inhibition of IL-18-induced IFN-gamma production. GSK1070806 77-87 interferon gamma Homo sapiens 180-189 24841172-4 2014 An unusual feature of IFN-gamma is that the protein contains no native cysteines. Cysteine 71-80 interferon gamma Homo sapiens 22-31 24995667-5 2014 RESULTS: Alcohol-use disorders patients with a positive history of MD had higher levels of the inflammatory cytokines IL-6 (P = 0.019), TNF (P = 0.020), and IFN-gamma (P = 0.001), but not of IL-10 (P = 0.853). Alcohols 9-16 interferon gamma Homo sapiens 157-166 25172501-8 2014 Inhibition of MIF greatly diminished the dermal infiltration of IFN-gamma(+) NKT cells, whereas the addition of exogenous TPA and MIF to NKT cells promoted their IFN-gamma production and migration, respectively. Tetradecanoylphorbol Acetate 122-125 interferon gamma Homo sapiens 162-171 25172501-10 2014 In TPA-induced skin inflammation, MIF is released from damaged keratinocytes and then triggers the chemotaxis of CD74(+)CXCR2(+) NKT cells for IFN-gamma production. Tetradecanoylphorbol Acetate 3-6 interferon gamma Homo sapiens 143-152 24388948-3 2014 Principal among these factors are Type I and Type II interferons (IFNs); the Type II IFN, IFN-gamma, stimulates the production of 1,25-dihydroxyvitamin D (1,25(OH)2D) from 25-hydroxyvitamin D (25OHD) by the granuloma-forming disease-activated macrophage, while the Type I IFNs, IFN-alpha and IFN-beta, block the hydroxylation reaction. 1,25-dihydroxyvitamin D 130-153 interferon gamma Homo sapiens 90-99 24388948-3 2014 Principal among these factors are Type I and Type II interferons (IFNs); the Type II IFN, IFN-gamma, stimulates the production of 1,25-dihydroxyvitamin D (1,25(OH)2D) from 25-hydroxyvitamin D (25OHD) by the granuloma-forming disease-activated macrophage, while the Type I IFNs, IFN-alpha and IFN-beta, block the hydroxylation reaction. 25-hydroxyvitamin D 172-191 interferon gamma Homo sapiens 90-99 24388948-5 2014 Tilting the balance in the human immune response toward a confined disease phenotype is enabled by the presence of sufficient extracellular 25OHD to modulate IFN-gamma-promoted and substrate 25OH-driven intracellular synthesis of 1,25(OH)2D. 25oh 140-144 interferon gamma Homo sapiens 158-167 24870617-10 2014 In comparison with the heterologous prime-boost regimen, the homologous prime-boost vaccinations with DNA co-administrated with polyinosinic-polycytidylic acid (poly I:C) generated the highest specific IgG and IgG2a titers as well as the greatest IFNgamma production. Poly I-C 128-159 interferon gamma Homo sapiens 247-255 24700514-6 2014 The EGCG also enhanced intracellular reactive oxygen species accumulation, c-Jun N-terminal kinase (JNK) phosphorylation, and interferon-gamma (IFN-gamma) gene expression, all of which are involved in PhB-induced apoptosis. epigallocatechin gallate 4-8 interferon gamma Homo sapiens 126-142 24700514-6 2014 The EGCG also enhanced intracellular reactive oxygen species accumulation, c-Jun N-terminal kinase (JNK) phosphorylation, and interferon-gamma (IFN-gamma) gene expression, all of which are involved in PhB-induced apoptosis. epigallocatechin gallate 4-8 interferon gamma Homo sapiens 144-153 24700514-7 2014 Taken together, our data suggest that EGCG is capable of potentiating photodynamic therapy responses, presumably through the intracellular oxidative stress-sensitive JNK/IFN-gamma pathway by exogenous hydrogen peroxide formation. epigallocatechin gallate 38-42 interferon gamma Homo sapiens 170-179 24700514-7 2014 Taken together, our data suggest that EGCG is capable of potentiating photodynamic therapy responses, presumably through the intracellular oxidative stress-sensitive JNK/IFN-gamma pathway by exogenous hydrogen peroxide formation. Hydrogen Peroxide 201-218 interferon gamma Homo sapiens 170-179 24841172-5 2014 To create a longer-acting and potentially more effective form of the protein, we introduced a cysteine residue into the IFN-gamma coding sequence at amino acid position 103, which is located in a surface-exposed, non-helical region of the protein. Cysteine 94-102 interferon gamma Homo sapiens 120-129 25247578-0 2014 Mycophenolate antagonizes IFN-gamma-induced catagen-like changes via beta-catenin activation in human dermal papilla cells and hair follicles. Mycophenolic Acid 0-13 interferon gamma Homo sapiens 26-35 25226283-7 2014 We demonstrated that DCE and CS decreased intracellular GSH levels in human keratinocytes, as well as inhibited STAT3 and STAT1 phosphorylation and activation triggered by IL-22 or IFN-gamma, respectively. dehydrocostus lactone 21-24 interferon gamma Homo sapiens 181-190 25226283-7 2014 We demonstrated that DCE and CS decreased intracellular GSH levels in human keratinocytes, as well as inhibited STAT3 and STAT1 phosphorylation and activation triggered by IL-22 or IFN-gamma, respectively. costunolide 29-31 interferon gamma Homo sapiens 181-190 25226283-11 2014 In light of our findings, we can hypothesize that the employment of DCE and CS in psoriasis could efficiently counteract the pro-inflammatory effects of IFN-gamma and IL-22 on keratinocytes, revert the apoptosis-resistant phenotype, as well as inhibit hyperproliferation in the psoriatic epidermis. dehydrocostus lactone 68-71 interferon gamma Homo sapiens 153-162 25226283-11 2014 In light of our findings, we can hypothesize that the employment of DCE and CS in psoriasis could efficiently counteract the pro-inflammatory effects of IFN-gamma and IL-22 on keratinocytes, revert the apoptosis-resistant phenotype, as well as inhibit hyperproliferation in the psoriatic epidermis. costunolide 76-78 interferon gamma Homo sapiens 153-162 25247578-2 2014 In this study, we investigate the influence of mycophenolate (MPA), an immunosuppressant, on the proliferation of human dermal papilla cells (hDPCs) and on the growth of human hair follicles following catagen induction with interferon (IFN)-gamma. Mycophenolic Acid 47-60 interferon gamma Homo sapiens 224-246 25092892-6 2014 We discovered that miR-3473b, which was significantly downregulated after IFN-gamma priming, could attenuate the priming effect of IFN-gamma. 3473b 23-28 interferon gamma Homo sapiens 74-83 25122922-5 2014 PL-C also synergized with IL-12, even at the low cytokine concentration of 0.1 ng/ml, and stimulated IFN-gamma production in both human CD56(bright) and CD56(dim) NK cell subsets. Carbon 3-4 interferon gamma Homo sapiens 101-110 25092892-6 2014 We discovered that miR-3473b, which was significantly downregulated after IFN-gamma priming, could attenuate the priming effect of IFN-gamma. 3473b 23-28 interferon gamma Homo sapiens 131-140 23969075-10 2014 Patients with aspirin intolerance had higher levels of IFN-gamma (4.7+-1.4 vs. 4.1+-0.6, respectively, p=0.022). Aspirin 14-21 interferon gamma Homo sapiens 55-64 25209422-0 2014 Cytokine response to selected MTB antigens in Ghanaian TB patients, before and at 2 weeks of anti-TB therapy is characterized by high expression of IFN-gamma and Granzyme B and inter- individual variation. Terbium 31-33 interferon gamma Homo sapiens 148-157 23969075-12 2014 IFN-gamma seems to be down-regulated in the patients with CRSwNP, but could be over-expressed in the presence of aspirin intolerance. Aspirin 113-120 interferon gamma Homo sapiens 0-9 25074847-0 2014 A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNgamma-activated BV2 microglia. artemisinin 31-42 interferon gamma Homo sapiens 99-107 25074847-0 2014 A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNgamma-activated BV2 microglia. Artesunate 44-54 interferon gamma Homo sapiens 99-107 25074847-0 2014 A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNgamma-activated BV2 microglia. Dinoprostone 64-80 interferon gamma Homo sapiens 99-107 25074847-2 2014 In this study, we have investigated the effect of artesunate on PGE2 production/COX-2 protein expression in LPS+IFNgamma-activated BV2 microglia. Artesunate 50-60 interferon gamma Homo sapiens 112-120 25414775-7 2014 We also measured the ability of BK extract to inhibit the secretion of hTARC in HaCaT cells after stimulation by TNF-alpha and IFN-gamma. Berkelium 32-34 interferon gamma Homo sapiens 127-136 25414775-9 2014 Moreover, 500 mug/mL of BK extract inhibited hTARC secretion in HaCaT cells by activated TNF-alpha/IFN-gamma by about 87%. Berkelium 24-26 interferon gamma Homo sapiens 99-108 25074847-2 2014 In this study, we have investigated the effect of artesunate on PGE2 production/COX-2 protein expression in LPS+IFNgamma-activated BV2 microglia. Dinoprostone 64-68 interferon gamma Homo sapiens 112-120 25074847-6 2014 Artesunate (2 and 4muM), significantly (p <0.01) suppressed PGE2 production in LPS+IFNgamma-activated BV2 microglia. Artesunate 0-10 interferon gamma Homo sapiens 86-94 25074847-6 2014 Artesunate (2 and 4muM), significantly (p <0.01) suppressed PGE2 production in LPS+IFNgamma-activated BV2 microglia. Dinoprostone 63-67 interferon gamma Homo sapiens 86-94 25074847-10 2014 Artesunate inhibited phosphorylation of p38 MAPK and its substrate MAPKAPK2 following stimulation of microglia with LPS+IFNgamma. Artesunate 0-10 interferon gamma Homo sapiens 120-128 24830761-9 2014 Significant inverse associations were reported between IL-6, TNF-alpha, and IFN-gamma levels and quartiles of total reported carotenoid intake (P = .006, P = .04, and P = .04, respectively). Carotenoids 125-135 interferon gamma Homo sapiens 76-85 24830761-10 2014 There was an inverse association between IFN-gamma levels and serum alpha-tocopherol levels (P = .03). alpha-Tocopherol 68-84 interferon gamma Homo sapiens 41-50 24983024-8 2014 QEPVL can also inhibit LPS-induced inflammation by regulating nitric oxide release and the production of the cytokines IL-4, IL-10, IFN-gamma, and TNF-alpha in vivo. qepvl 0-5 interferon gamma Homo sapiens 132-141 24975831-9 2014 All groups decreased pro-inflammatory cytokine TNF-alpha and increased anti-inflammatory IL-10 production although only vitamin C decreased IFN-gamma either alone or when combined with FUCO. Ascorbic Acid 120-129 interferon gamma Homo sapiens 140-149 25317018-1 2014 We evaluated the effect of cobalt chloride (CoCl2) on TNF-alpha and IFN-gamma-induced-inflammation and reactive oxygen species (ROS) in renal tubular epithelial cells (HK-2 cells). cobaltous chloride 27-42 interferon gamma Homo sapiens 68-77 25317018-1 2014 We evaluated the effect of cobalt chloride (CoCl2) on TNF-alpha and IFN-gamma-induced-inflammation and reactive oxygen species (ROS) in renal tubular epithelial cells (HK-2 cells). cobaltous chloride 44-49 interferon gamma Homo sapiens 68-77 25317018-2 2014 We treated HK-2 cells with CoCl2 before the administration of TNF-alpha/IFN-gamma. cobaltous chloride 27-32 interferon gamma Homo sapiens 72-81 25317018-4 2014 CoCl2 reduced the generation of ROS induced by TNF-alpha/IFN-gamma. cobaltous chloride 0-5 interferon gamma Homo sapiens 57-66 25317018-4 2014 CoCl2 reduced the generation of ROS induced by TNF-alpha/IFN-gamma. Reactive Oxygen Species 32-35 interferon gamma Homo sapiens 57-66 25317018-12 2014 We suggest that CoCl2 has a protective effect on TNF-alpha/IFN-gamma-induced inflammation through the inhibition of NF-kappaB and ROS in HK-2 cells. cobaltous chloride 16-21 interferon gamma Homo sapiens 59-68 25317018-12 2014 We suggest that CoCl2 has a protective effect on TNF-alpha/IFN-gamma-induced inflammation through the inhibition of NF-kappaB and ROS in HK-2 cells. Reactive Oxygen Species 130-133 interferon gamma Homo sapiens 59-68 24518246-4 2014 We found that IL-13 and IFN-gamma synergistically enhanced iNOS, nitrite, and 3NT, corresponding with increased H(2)O(2). Nitrites 65-72 interferon gamma Homo sapiens 24-33 24518246-6 2014 Dual oxidase-2 (DUOX2), central to H(2)O(2) formation, was also synergistically induced by IL-13 and IFN-gamma. Hydrogen Peroxide 35-43 interferon gamma Homo sapiens 101-110 24518246-9 2014 IFN-gamma induced TPO in HAEC and small interfering RNA knockdown decreased nitrated tyrosine residues. Tyrosine 85-93 interferon gamma Homo sapiens 0-9 25175005-2 2014 In this study we investigated the effect of the flavonoid present in green tea, namely epigallocatechin-3-gallate (EGCG), on the proliferation of, and IFN-gamma production by, peripheral blood mononuclear cells (PBMC) from breast cancer patients stimulated with a mitogen, anti-CD3 and the common breast cancer peptides Her-2/neu, and p53. Flavonoids 48-57 interferon gamma Homo sapiens 151-160 24602010-2 2014 We have previously reported that quercetagetin has an inhibitory activity on inflammatory chemokines, which is induced by interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha, occurring via inhibition of the signal transducer and activator of transcription 1 (STAT1) signal. quercetagetin 33-46 interferon gamma Homo sapiens 122-144 24602010-7 2014 RESULTS: Quercetagetin inhibited the expression of MDC at both the protein and mRNA levels in IFN-gamma- and TNF-alpha-stimulated HaCaT human keratinocytes. quercetagetin 9-22 interferon gamma Homo sapiens 94-103 25175005-2 2014 In this study we investigated the effect of the flavonoid present in green tea, namely epigallocatechin-3-gallate (EGCG), on the proliferation of, and IFN-gamma production by, peripheral blood mononuclear cells (PBMC) from breast cancer patients stimulated with a mitogen, anti-CD3 and the common breast cancer peptides Her-2/neu, and p53. epigallocatechin gallate 87-113 interferon gamma Homo sapiens 151-160 25149535-6 2014 The addition of AZD1480 to co-cultures of human MDSCs and T cells does not affect the suppressive activity of MDSCs but it does reduce the IFN-gamma secretion and the proliferative capacity of T cells. AZD 1480 16-23 interferon gamma Homo sapiens 139-148 25175005-2 2014 In this study we investigated the effect of the flavonoid present in green tea, namely epigallocatechin-3-gallate (EGCG), on the proliferation of, and IFN-gamma production by, peripheral blood mononuclear cells (PBMC) from breast cancer patients stimulated with a mitogen, anti-CD3 and the common breast cancer peptides Her-2/neu, and p53. epigallocatechin gallate 115-119 interferon gamma Homo sapiens 151-160 25175005-9 2014 IFN-gamma production was also significantly suppressed by EGCG in vitro. epigallocatechin gallate 58-62 interferon gamma Homo sapiens 0-9 25108672-10 2014 CD4+ T cells especially benefit from Treg depletion exhibiting a two-fold increase of CD69+ cells 40 h and IFN-gamma+ cells 7 days p.i. treg 37-41 interferon gamma Homo sapiens 107-116 25102056-4 2014 Mass spectrometric analysis has revealed potential MHC I-associated peptides on the HSG cells, including a tryptic peptide derived from salivary amylase, due to IFN-gamma stimulation. Peptides 68-75 interferon gamma Homo sapiens 161-170 25102056-7 2014 We have also found that lactacystin, a proteasome inhibitor, inhibits the expression of beta1 subunit in HSG cells and blocks the IFN-gamma-induced expression of beta1i and immunoproteasome activity. lactacystin 24-35 interferon gamma Homo sapiens 130-139 25090227-7 2014 Among the anti-inflammatory cytokines, the production of prostaglandin E2 (PGE2) and the expression of its primary enzyme, cyclooxygenase-2 (COX-2), were profoundly increased by pre-stimulation with interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha), and this response was significantly decreased with consecutive passages. Dinoprostone 57-73 interferon gamma Homo sapiens 199-226 24997049-6 2014 Exposure of cultured microglia and macrophages to IFN-gamma abrogated subsequent IL-10 induction by HSPB5, and strongly promoted HSPB5-triggered release of TNF-alpha, IL-6, IL-12, IL-1beta and reactive oxygen and nitrogen species. reactive oxygen and nitrogen species 193-229 interferon gamma Homo sapiens 50-59 24911373-8 2014 Stimulation of human Caco-2BBe cells with IFN-gamma caused MLCK-dependent TW arc formation and brush border fanning, which preceded caveolin-mediated bacterial internalization through cholesterol-rich lipid rafts. Cholesterol 184-195 interferon gamma Homo sapiens 42-51 24554396-7 2014 Re-stimulation with unspecific stimuli (PMA and ionomycin) generated a mixed Th1 (CD4(+)/IFN-gamma(+)) and Th17 (CD4(+)/IL-17(+)) phenotype in comparison with the vehicle-matched group. Ionomycin 48-57 interferon gamma Homo sapiens 89-102 24812273-3 2014 We formulated an IFNgamma-inducing cancer vaccine called TEGVAX that combined GM-CSF and multiple Toll-like receptor agonists to increase the number of activated dendritic cells. tegvax 57-63 interferon gamma Homo sapiens 17-25 24577604-8 2014 RESULTS: The TB antigen-stimulated levels of IFN-gamma, I-TAC, and MIG were significantly increased in the active pulmonary TB group compared with all other groups. Terbium 13-15 interferon gamma Homo sapiens 45-54 24577604-8 2014 RESULTS: The TB antigen-stimulated levels of IFN-gamma, I-TAC, and MIG were significantly increased in the active pulmonary TB group compared with all other groups. Terbium 124-126 interferon gamma Homo sapiens 45-54 24577604-10 2014 The areas under the curve (95% CI) for differentiating active pulmonary TB from all other groups were 0.893 (0.864-0.924) for IFN-gamma, 0.962 (0.946-0.978) for I-TAC, and 0.944 (0.922-0.965) for MIG. Terbium 72-74 interferon gamma Homo sapiens 126-135 25009619-10 2014 The effects of GTS-21 were blocked by the alpha7nAchR antagonist alpha-bungarotoxin, which increased the expression of IFN-gamma and TBX21. 3-(2,4-dimethoxybenzylidene)anabaseine 15-21 interferon gamma Homo sapiens 119-128 24224571-0 2014 Interferon-alpha and interferon-gamma modulate Fas-mediated apoptosis in mitomycin-C-resistant human Tenon"s fibroblasts. ammonium ferrous sulfate 47-50 interferon gamma Homo sapiens 21-37 24224571-0 2014 Interferon-alpha and interferon-gamma modulate Fas-mediated apoptosis in mitomycin-C-resistant human Tenon"s fibroblasts. Mitomycin 73-84 interferon gamma Homo sapiens 21-37 24224571-2 2014 METHODS: A clinically resistant and in vitro verified mitomycin-C-resistant human Tenon"s fibroblast cell line was pretreated with interferon-alpha and interferon-gamma for 48 h before stimulation with an agonistic Fas antibody (CH11) for 2 days to induce cell death. Mitomycin 54-65 interferon gamma Homo sapiens 152-168 24224571-12 2014 CONCLUSIONS: Interferon-alpha and interferon-gamma render mitomycin-C-resistant human Tenon"s fibroblast cell line sensitive to Fas-mediated apoptosis. Mitomycin 58-69 interferon gamma Homo sapiens 34-50 24224571-12 2014 CONCLUSIONS: Interferon-alpha and interferon-gamma render mitomycin-C-resistant human Tenon"s fibroblast cell line sensitive to Fas-mediated apoptosis. ammonium ferrous sulfate 128-131 interferon gamma Homo sapiens 34-50 24137042-7 2014 In relation to the objectives of the study, we concluded that (a) IFN-gamma at biologically relevant concentrations significantly enhanced pro-inflammatory responses; (b) CSE, nicotine and cotinine dysregulated the inflammatory response and that the effects of CSE were different from those of the individual components, nicotine and cotinine; (c) when both IFN-gamma and CSE were present, IFN-gamma masked the effect of CSE. Cotinine 189-197 interferon gamma Homo sapiens 66-75 24137042-7 2014 In relation to the objectives of the study, we concluded that (a) IFN-gamma at biologically relevant concentrations significantly enhanced pro-inflammatory responses; (b) CSE, nicotine and cotinine dysregulated the inflammatory response and that the effects of CSE were different from those of the individual components, nicotine and cotinine; (c) when both IFN-gamma and CSE were present, IFN-gamma masked the effect of CSE. Cotinine 189-197 interferon gamma Homo sapiens 358-367 24137042-7 2014 In relation to the objectives of the study, we concluded that (a) IFN-gamma at biologically relevant concentrations significantly enhanced pro-inflammatory responses; (b) CSE, nicotine and cotinine dysregulated the inflammatory response and that the effects of CSE were different from those of the individual components, nicotine and cotinine; (c) when both IFN-gamma and CSE were present, IFN-gamma masked the effect of CSE. Cotinine 189-197 interferon gamma Homo sapiens 358-367 24137042-7 2014 In relation to the objectives of the study, we concluded that (a) IFN-gamma at biologically relevant concentrations significantly enhanced pro-inflammatory responses; (b) CSE, nicotine and cotinine dysregulated the inflammatory response and that the effects of CSE were different from those of the individual components, nicotine and cotinine; (c) when both IFN-gamma and CSE were present, IFN-gamma masked the effect of CSE. Nicotine 321-329 interferon gamma Homo sapiens 66-75 24137042-7 2014 In relation to the objectives of the study, we concluded that (a) IFN-gamma at biologically relevant concentrations significantly enhanced pro-inflammatory responses; (b) CSE, nicotine and cotinine dysregulated the inflammatory response and that the effects of CSE were different from those of the individual components, nicotine and cotinine; (c) when both IFN-gamma and CSE were present, IFN-gamma masked the effect of CSE. Cotinine 334-342 interferon gamma Homo sapiens 66-75 24989637-1 2014 One of the most significant activities induced by interferon-gamma against intracellular pathogens is the induction of IDO (indoleamine 2,3-dioxygenase) expression, which subsequently results in the depletion of tryptophan. Tryptophan 212-222 interferon gamma Homo sapiens 50-66 24989637-6 2014 Exquisite susceptibility to IFN-gamma, specifically due to tryptophan availability appears to be a core adaptation of the human C. pneumoniae strains, which may reflect the chronic nature of their infections in this host. Tryptophan 59-69 interferon gamma Homo sapiens 28-37 24817202-1 2014 UNLABELLED: The cytokine interferon gamma (IFN-gamma) stimulates neopterin release and tryptophan degradation into kynurenines through the kynurenine pathway. Neopterin 65-74 interferon gamma Homo sapiens 25-52 24817202-1 2014 UNLABELLED: The cytokine interferon gamma (IFN-gamma) stimulates neopterin release and tryptophan degradation into kynurenines through the kynurenine pathway. Tryptophan 87-97 interferon gamma Homo sapiens 25-52 24817202-1 2014 UNLABELLED: The cytokine interferon gamma (IFN-gamma) stimulates neopterin release and tryptophan degradation into kynurenines through the kynurenine pathway. Kynurenine 115-126 interferon gamma Homo sapiens 25-52 24817202-1 2014 UNLABELLED: The cytokine interferon gamma (IFN-gamma) stimulates neopterin release and tryptophan degradation into kynurenines through the kynurenine pathway. Kynurenine 115-125 interferon gamma Homo sapiens 25-52 24817202-2 2014 High levels of neopterin were associated with increased hip fracture risk, as were some of the kynurenines, suggesting a role of IFN-gamma-mediated inflammation in the processes leading to hip fracture. Neopterin 15-24 interferon gamma Homo sapiens 129-138 24817202-4 2014 Interferon gamma (IFN-gamma) initiates macrophage release of neopterin and also stimulates degradation of tryptophan along the kynurenine pathway as part of cell-mediated immune activation. Neopterin 61-70 interferon gamma Homo sapiens 0-16 24817202-4 2014 Interferon gamma (IFN-gamma) initiates macrophage release of neopterin and also stimulates degradation of tryptophan along the kynurenine pathway as part of cell-mediated immune activation. Neopterin 61-70 interferon gamma Homo sapiens 18-27 24817202-4 2014 Interferon gamma (IFN-gamma) initiates macrophage release of neopterin and also stimulates degradation of tryptophan along the kynurenine pathway as part of cell-mediated immune activation. Tryptophan 106-116 interferon gamma Homo sapiens 0-16 24817202-4 2014 Interferon gamma (IFN-gamma) initiates macrophage release of neopterin and also stimulates degradation of tryptophan along the kynurenine pathway as part of cell-mediated immune activation. Tryptophan 106-116 interferon gamma Homo sapiens 18-27 24817202-4 2014 Interferon gamma (IFN-gamma) initiates macrophage release of neopterin and also stimulates degradation of tryptophan along the kynurenine pathway as part of cell-mediated immune activation. Kynurenine 127-137 interferon gamma Homo sapiens 0-16 24817202-4 2014 Interferon gamma (IFN-gamma) initiates macrophage release of neopterin and also stimulates degradation of tryptophan along the kynurenine pathway as part of cell-mediated immune activation. Kynurenine 127-137 interferon gamma Homo sapiens 18-27 24817202-5 2014 Plasma neopterin and the kynurenine/tryptophan ratio (KTR) are thus markers of IFN-gamma-mediated inflammation. Neopterin 7-16 interferon gamma Homo sapiens 79-88 24817202-5 2014 Plasma neopterin and the kynurenine/tryptophan ratio (KTR) are thus markers of IFN-gamma-mediated inflammation. Kynurenine 25-35 interferon gamma Homo sapiens 79-88 24817202-5 2014 Plasma neopterin and the kynurenine/tryptophan ratio (KTR) are thus markers of IFN-gamma-mediated inflammation. Tryptophan 36-46 interferon gamma Homo sapiens 79-88 24989637-4 2014 Strikingly, the IFN-gamma induced loss of ability to form infectious progeny production was completely rescued by removal of the IFN-gamma and addition of exogenous tryptophan for the human strains, but not the animal strains. Tryptophan 165-175 interferon gamma Homo sapiens 16-25 25022840-9 2014 CONCLUSIONS: The analysis of serum biomarkers IFN-gamma and IL-10, in association to PRNT and viremia, support the recommendation of use of a ten-fold lower subdose (3,013 IU) of 17DD-YF vaccine. 17dd-yf 179-186 interferon gamma Homo sapiens 46-55 24814730-7 2014 Interferon-gamma (IFN-gamma) stimulation of human macrophage lineage cells induced GAT-2 expression and reduced extracellular GABA levels (p<0.05) but soluble GABA treatment suppressed HLA-DRalpha, GAT-2 and XBP-1/s expression in stimulated macrophage lineage cells (p<0.05). gamma-Aminobutyric Acid 126-130 interferon gamma Homo sapiens 0-16 24814730-7 2014 Interferon-gamma (IFN-gamma) stimulation of human macrophage lineage cells induced GAT-2 expression and reduced extracellular GABA levels (p<0.05) but soluble GABA treatment suppressed HLA-DRalpha, GAT-2 and XBP-1/s expression in stimulated macrophage lineage cells (p<0.05). gamma-Aminobutyric Acid 126-130 interferon gamma Homo sapiens 18-27 24814730-7 2014 Interferon-gamma (IFN-gamma) stimulation of human macrophage lineage cells induced GAT-2 expression and reduced extracellular GABA levels (p<0.05) but soluble GABA treatment suppressed HLA-DRalpha, GAT-2 and XBP-1/s expression in stimulated macrophage lineage cells (p<0.05). gamma-Aminobutyric Acid 162-166 interferon gamma Homo sapiens 0-16 24814730-7 2014 Interferon-gamma (IFN-gamma) stimulation of human macrophage lineage cells induced GAT-2 expression and reduced extracellular GABA levels (p<0.05) but soluble GABA treatment suppressed HLA-DRalpha, GAT-2 and XBP-1/s expression in stimulated macrophage lineage cells (p<0.05). gamma-Aminobutyric Acid 162-166 interferon gamma Homo sapiens 18-27 25076907-5 2014 Opposite, iron and the erythropoiesis inducing hormone erythropoietin affect innate immune responses by influencing interferon-gamma (IFN-gamma) mediated (iron) or NF-kB inducible (erythropoietin) immune effector pathways in macrophages. Iron 10-14 interferon gamma Homo sapiens 116-132 25076907-5 2014 Opposite, iron and the erythropoiesis inducing hormone erythropoietin affect innate immune responses by influencing interferon-gamma (IFN-gamma) mediated (iron) or NF-kB inducible (erythropoietin) immune effector pathways in macrophages. Iron 10-14 interferon gamma Homo sapiens 134-143 25076907-5 2014 Opposite, iron and the erythropoiesis inducing hormone erythropoietin affect innate immune responses by influencing interferon-gamma (IFN-gamma) mediated (iron) or NF-kB inducible (erythropoietin) immune effector pathways in macrophages. Iron 155-159 interferon gamma Homo sapiens 116-132 25076907-5 2014 Opposite, iron and the erythropoiesis inducing hormone erythropoietin affect innate immune responses by influencing interferon-gamma (IFN-gamma) mediated (iron) or NF-kB inducible (erythropoietin) immune effector pathways in macrophages. Iron 155-159 interferon gamma Homo sapiens 134-143 25076907-6 2014 Thus, macrophages loaded with iron lose their ability to kill intracellular pathogens via IFN-gamma mediated effector pathways such as nitric oxide (NO) formation. Iron 30-34 interferon gamma Homo sapiens 90-99 25076907-6 2014 Thus, macrophages loaded with iron lose their ability to kill intracellular pathogens via IFN-gamma mediated effector pathways such as nitric oxide (NO) formation. Nitric Oxide 135-147 interferon gamma Homo sapiens 90-99 24953652-4 2014 Pharmacologic depletion of EZH2 by the histone-methylation inhibitor DZNep mimicked the effects of EZH2 knockdown on IFNGR1 induction and delivered a remarkable synergistic antitumor effect with IFN-gamma. 3-deazaneplanocin 69-74 interferon gamma Homo sapiens 195-204 24743029-6 2014 Additionally, ceftriaxone treatment for 2 days significantly reduced the IFNgamma level in PFC. Ceftriaxone 14-25 interferon gamma Homo sapiens 73-81 24801891-5 2014 Phorbol myristate acetate-stimulated whole blood interleukin (IL)-4, IL-5, IL-10, IL-12, IL-13, IL-17A, IL-17F, IL-22, and interferon-gamma secretory responses were analyzed for associations comparing participants with allergic vs nonallergic asthma phenotypes with those without asthma. Tetradecanoylphorbol Acetate 0-25 interferon gamma Homo sapiens 123-139 24788303-6 2014 The expression of important pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6 and interferon-gamma), which was quantified using ELISA showed that simvastatin decreased the expression of pro-inflammatory cytokines to an average of 2-fold. Simvastatin 167-178 interferon gamma Homo sapiens 103-119 24725826-5 2014 A reduction in LPS/IFN-gamma-induced nuclear factor (NF)-kappaB activation was also observed in PMC-treated VSMCs. vsmcs 108-113 interferon gamma Homo sapiens 19-28 24725826-6 2014 The translocation and phosphorylation of p65, protein phosphatase 2A (PP2A) inactivation and the formation of reactive oxygen species (ROS) were significantly inhibited by PMC in LPS/IFN-gamma-activated VSMCs. Reactive Oxygen Species 110-133 interferon gamma Homo sapiens 183-192 24652540-7 2014 In addition, we show that extracellular cAMP affects monocyte differentiation into DCs, promoting the induction of cells displaying an activated, macrophage-like phenotype with reduced capacity of polarized, naive CD4(+) T cells into IFN-gamma-producing lymphocytes compared with control cells. Cyclic AMP 40-44 interferon gamma Homo sapiens 234-243 24725826-6 2014 The translocation and phosphorylation of p65, protein phosphatase 2A (PP2A) inactivation and the formation of reactive oxygen species (ROS) were significantly inhibited by PMC in LPS/IFN-gamma-activated VSMCs. Reactive Oxygen Species 135-138 interferon gamma Homo sapiens 183-192 24725826-11 2014 These results collectively indicate that the PMC-mediated inhibition of NF-kappaB activity in LPS/IFN-gamma-stimulated VSMCs occurs through the ROS-PP2A-p65 signalling cascade, an IKK-IkappaBalpha-independent mechanism. Reactive Oxygen Species 144-147 interferon gamma Homo sapiens 98-107 24406841-7 2014 Treatment with ruxolitinib also resulted in the reduction of key cytokines (tumor necrosis factor alpha, interleukin-4 (IL-4), IL-6 and IL-8) and induction of interferon-gamma. ruxolitinib 15-26 interferon gamma Homo sapiens 159-175 24837237-7 2014 Direct interactions between quinolines and the oxygenases of the pathway (especially with the indoleamine (2,3)-dioxygenase and kynurenine-monoxygenase) and indirect influences via the interferon-gamma induced breakdown of tryptophane are discussed, as well as the modifying effect of the already existing neurotoxicity of the single quinoline related drug used. Quinolines 28-38 interferon gamma Homo sapiens 185-201 24837237-7 2014 Direct interactions between quinolines and the oxygenases of the pathway (especially with the indoleamine (2,3)-dioxygenase and kynurenine-monoxygenase) and indirect influences via the interferon-gamma induced breakdown of tryptophane are discussed, as well as the modifying effect of the already existing neurotoxicity of the single quinoline related drug used. indolamine 94-105 interferon gamma Homo sapiens 185-201 24837237-7 2014 Direct interactions between quinolines and the oxygenases of the pathway (especially with the indoleamine (2,3)-dioxygenase and kynurenine-monoxygenase) and indirect influences via the interferon-gamma induced breakdown of tryptophane are discussed, as well as the modifying effect of the already existing neurotoxicity of the single quinoline related drug used. Tryptophan 223-234 interferon gamma Homo sapiens 185-201 24837237-7 2014 Direct interactions between quinolines and the oxygenases of the pathway (especially with the indoleamine (2,3)-dioxygenase and kynurenine-monoxygenase) and indirect influences via the interferon-gamma induced breakdown of tryptophane are discussed, as well as the modifying effect of the already existing neurotoxicity of the single quinoline related drug used. quinoline 28-37 interferon gamma Homo sapiens 185-201 25001926-6 2014 Compared with the IFN-gamma plus TNF-alpha group (untreated with 15d-PGJ2), the CXCL9, CXCL10 and CXCL11 were depressed by 76.8%, 78.7% and 81.9% at mRNA level and 66.9%, 86.6% and 39.9% at protein level in 2.0 ng/mL 15d-PGJ2-treated HK-2 cells, respectively (P<0.05). 9-deoxy-delta-9-prostaglandin D2 68-73 interferon gamma Homo sapiens 18-27 24838635-8 2014 The expression of STAT1 phosphorylated on tyrosine 701 (Y701) was increased by interferon-gamma (IFN-gamma) treatment, whereas SOCS1 was not expressed. Tyrosine 42-50 interferon gamma Homo sapiens 79-95 24838635-8 2014 The expression of STAT1 phosphorylated on tyrosine 701 (Y701) was increased by interferon-gamma (IFN-gamma) treatment, whereas SOCS1 was not expressed. Tyrosine 42-50 interferon gamma Homo sapiens 97-106 25001926-7 2014 CONCLUSION: PPAR-gamma agonist 15d-PGJ2 could inhibit CXCL9, CXCL10 and CXCL11 production induced by IFN-gamma combined with TNF-alpha in HK-2 cells. 15-deoxyprostaglandin J2 31-39 interferon gamma Homo sapiens 101-110 24978193-6 2014 However, the stable ATP analogue ATPgammaS increased the release of IL-1beta and IFNgamma, and the effect was greatly increased in lungs from smokers. Adenosine Triphosphate 20-23 interferon gamma Homo sapiens 81-89 24978193-6 2014 However, the stable ATP analogue ATPgammaS increased the release of IL-1beta and IFNgamma, and the effect was greatly increased in lungs from smokers. adenosine 5'-O-(3-thiotriphosphate) 33-42 interferon gamma Homo sapiens 81-89 24811173-0 2014 Caerulomycin A enhances transforming growth factor-beta (TGF-beta)-Smad3 protein signaling by suppressing interferon-gamma (IFN-gamma)-signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs). caerulomycin A 0-14 interferon gamma Homo sapiens 106-122 24811173-0 2014 Caerulomycin A enhances transforming growth factor-beta (TGF-beta)-Smad3 protein signaling by suppressing interferon-gamma (IFN-gamma)-signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs). caerulomycin A 0-14 interferon gamma Homo sapiens 124-133 24811173-5 2014 In addition, CaeA significantly suppressed the number of Th1 and Th17 cells, as supported by a decreased percentage of CD4(+)/IFN-gamma(+) and CD4(+)/IL-17(+) cells, respectively. caerulomycin A 13-17 interferon gamma Homo sapiens 126-135 24811173-6 2014 Furthermore, we established the mechanism and observed that CaeA interfered with IFN-gamma-induced STAT1 signaling by augmenting SOCS1 expression. caerulomycin A 60-64 interferon gamma Homo sapiens 81-90 24811173-8 2014 Furthermore, CaeA rescued Tregs from IFN-gamma-induced inhibition. caerulomycin A 13-17 interferon gamma Homo sapiens 37-46 24932497-6 2014 mDCs adhesion to CASMCs was enhanced by CASMC pre-treatment with IFNgamma and TNFalpha ICAM-1 and VCAM-1 were involved, since the expression of specific mRNAs for these molecules increased and adhesion was inhibited by neutralizing antibodies to the counter-receptors CD11c and CD18. casmcs 17-23 interferon gamma Homo sapiens 65-73 24932497-6 2014 mDCs adhesion to CASMCs was enhanced by CASMC pre-treatment with IFNgamma and TNFalpha ICAM-1 and VCAM-1 were involved, since the expression of specific mRNAs for these molecules increased and adhesion was inhibited by neutralizing antibodies to the counter-receptors CD11c and CD18. casmc 17-22 interferon gamma Homo sapiens 65-73 25035772-13 2014 However,the IFN-gamma level in BALF was lower compared with the negative control and PBS group (P < 0.05) but with the OVA group (P > 0.05). Lead 85-88 interferon gamma Homo sapiens 12-21 24808363-5 2014 Importantly, repeated treatments with ECDI-SPs induce the CD11b(+)Gr1(high) cells to produce a high level of IFN-gamma and to exhibit an enhanced responsiveness to IFN-gamma by expressing higher levels of downstream effector molecules ido and nos2. ecdi-sps 38-46 interferon gamma Homo sapiens 109-118 24808363-5 2014 Importantly, repeated treatments with ECDI-SPs induce the CD11b(+)Gr1(high) cells to produce a high level of IFN-gamma and to exhibit an enhanced responsiveness to IFN-gamma by expressing higher levels of downstream effector molecules ido and nos2. ecdi-sps 38-46 interferon gamma Homo sapiens 164-173 24808363-7 2014 We conclude that donor ECDI-SPs induce the expansion of two populations of MDSCs important for allograft protection mediated in part by intrinsic IFN-gamma-dependent mechanisms. ecdi-sps 23-31 interferon gamma Homo sapiens 146-155 24924312-0 2014 Benzylideneacetophenone derivatives attenuate IFN-gamma-induced IP-10/CXCL10 production in orbital fibroblasts of patients with thyroid-associated ophthalmopathy through STAT-1 inhibition. Chalcone 0-23 interferon gamma Homo sapiens 46-55 24924312-5 2014 JC3 exerted a significant inhibitory effect on the IFN-gamma-induced increase in IP-10/CXCL10 in a dose-dependent manner; its potency was greater than that of an identical concentration of yakuchinone B with no toxicity to cells at the concentration range used. yakuchinone B 189-202 interferon gamma Homo sapiens 51-60 24711661-5 2014 Mechanistically, we could show that ruxolitinib impaired differentiation of CD4(+) T cells into IFN-gamma- and IL17A-producing cells, and that both T-cell phenotypes are linked to GVHD. ruxolitinib 36-47 interferon gamma Homo sapiens 96-105 25001926-5 2014 PPAR-gamma agonist 15d-PGJ2 inhibited the expressions of CXCL9, CXCL10 and CXCL11 in IFN-gamma combined with TNF-alpha-induced HK-2 cells. 15-deoxyprostaglandin J2 19-27 interferon gamma Homo sapiens 85-94 24911872-6 2014 Interestingly, fludarabine was efficient in suppressing protein expression and consequently IDO activity in two different cell lines derived from breast cancer and melanoma when IDO was activated with interferon-gamma (IFN-gamma) or supernatants prepared from activated T lymphocytes. fludarabine 15-26 interferon gamma Homo sapiens 201-217 24911872-6 2014 Interestingly, fludarabine was efficient in suppressing protein expression and consequently IDO activity in two different cell lines derived from breast cancer and melanoma when IDO was activated with interferon-gamma (IFN-gamma) or supernatants prepared from activated T lymphocytes. fludarabine 15-26 interferon gamma Homo sapiens 219-228 24911872-8 2014 Other IFN-gamma-responsive genes were only marginally inhibited by fludarabine. fludarabine 67-78 interferon gamma Homo sapiens 6-15 24883198-5 2014 The intermediate plus strain vaccinate was observed to induce higher levels of IFN-gamma in the birds. vaccinate 29-38 interferon gamma Homo sapiens 79-88 24918090-4 2014 IFNgamma acts by inducing the host enzyme indoleamine 2,3-dioxgenase, which catabolizes tryptophan, thereby depriving the bacterium of this essential amino acid. Tryptophan 88-98 interferon gamma Homo sapiens 0-8 24918090-4 2014 IFNgamma acts by inducing the host enzyme indoleamine 2,3-dioxgenase, which catabolizes tryptophan, thereby depriving the bacterium of this essential amino acid. Amino Acids, Essential 140-160 interferon gamma Homo sapiens 0-8 24918090-9 2014 In vitro studies have confirmed the capacity of indole to mitigate the effects of IFNgamma; it has been suggested that a perturbed vaginal microbiome may provide a source of indole in vivo. indole 48-54 interferon gamma Homo sapiens 82-90 25003726-9 2014 In addition, nitric oxide and p53 protein increased in IFN-gamma treated cells. Nitric Oxide 13-25 interferon gamma Homo sapiens 55-64 24528145-2 2014 In cell-mediated immune activation, interferon (IFN)-gamma stimulates macrophage release of neopterin and increases the activity of indoleamine 2,3-dioxygenase (IDO), thereby stimulating tryptophan degradation along the kynurenine pathway. Neopterin 92-101 interferon gamma Homo sapiens 36-58 24528145-2 2014 In cell-mediated immune activation, interferon (IFN)-gamma stimulates macrophage release of neopterin and increases the activity of indoleamine 2,3-dioxygenase (IDO), thereby stimulating tryptophan degradation along the kynurenine pathway. Tryptophan 187-197 interferon gamma Homo sapiens 36-58 24528145-2 2014 In cell-mediated immune activation, interferon (IFN)-gamma stimulates macrophage release of neopterin and increases the activity of indoleamine 2,3-dioxygenase (IDO), thereby stimulating tryptophan degradation along the kynurenine pathway. Kynurenine 220-230 interferon gamma Homo sapiens 36-58 24528145-3 2014 Plasma levels of neopterin and the kynurenine/tryptophan ratio (KTR) are thus markers of IFN-gamma-mediated inflammation. Neopterin 17-26 interferon gamma Homo sapiens 89-98 24528145-3 2014 Plasma levels of neopterin and the kynurenine/tryptophan ratio (KTR) are thus markers of IFN-gamma-mediated inflammation. Kynurenine 35-45 interferon gamma Homo sapiens 89-98 24528145-3 2014 Plasma levels of neopterin and the kynurenine/tryptophan ratio (KTR) are thus markers of IFN-gamma-mediated inflammation. Tryptophan 46-56 interferon gamma Homo sapiens 89-98 24528145-5 2014 The aim of this study was to investigate associations between markers of IFN-gamma-mediated inflammation and kynurenines with bone mineral density (BMD). Kynurenine 109-120 interferon gamma Homo sapiens 73-82 24528247-10 2014 T cell proliferation as well as interleukin (IL)-4, IL-13, IL-10 and interferon (IFN)-gamma production were strongly decreased using glutaraldehyde-modified allergoids, but did not differ between alum-adsorbed allergens or allergoids and the corresponding unadsorbed preparations. Glutaral 133-147 interferon gamma Homo sapiens 69-91 24606499-4 2014 Among various other molecular and cellular effects, IFN-gamma activates the enzyme indoleamine 2,3-dioxygenase (IDO) in monocyte-derived macrophages, dendritic, and other cells, which, in turn, decreases serum levels of the essential amino acid tryptophan (TRP). essential amino acid tryptophan 224-255 interferon gamma Homo sapiens 52-61 24606499-4 2014 Among various other molecular and cellular effects, IFN-gamma activates the enzyme indoleamine 2,3-dioxygenase (IDO) in monocyte-derived macrophages, dendritic, and other cells, which, in turn, decreases serum levels of the essential amino acid tryptophan (TRP). Tryptophan 257-260 interferon gamma Homo sapiens 52-61 24510590-4 2014 TAMs also induced the release of IFN-gamma from NK cells, which however was significantly lower compared with that induced by in vitro-polarized M2 cells. tams 0-4 interferon gamma Homo sapiens 33-42 24675422-8 2014 Galangin suppressed DFE/DNCB-induced expression of interleukin (IL)-4, IL-5, IL-13, IL-31, IL-32, and interferon (IFN)-gamma in the ear tissue. galangin 0-8 interferon gamma Homo sapiens 102-124 24675422-8 2014 Galangin suppressed DFE/DNCB-induced expression of interleukin (IL)-4, IL-5, IL-13, IL-31, IL-32, and interferon (IFN)-gamma in the ear tissue. 1,1-difluoroethane 20-23 interferon gamma Homo sapiens 102-124 24675422-8 2014 Galangin suppressed DFE/DNCB-induced expression of interleukin (IL)-4, IL-5, IL-13, IL-31, IL-32, and interferon (IFN)-gamma in the ear tissue. Dinitrochlorobenzene 24-28 interferon gamma Homo sapiens 102-124 24704449-0 2014 (+)-Nootkatone inhibits tumor necrosis factor alpha/interferon gamma-induced production of chemokines in HaCaT cells. nootkatone 0-14 interferon gamma Homo sapiens 52-68 24856796-8 2014 MAIN RESULTS: The dexmedetomidine group displayed higher levels of IFN-gamma at T1 and T2 (42.30 pg/dL vs 6.91 pg/dL at T1 [P = 0.025]; 40.51 pg/dL vs 8.29 pg/dL at T2 [P = 0.030]) than the saline group. Dexmedetomidine 18-33 interferon gamma Homo sapiens 67-76 24856796-9 2014 The dexmedetomidine group was also associated with higher ratios of IFN-gamma/IL-4 (1.22 vs 0.32, respectively, at T1 [P = 0.012]; 1.53 vs 0.13, respectively, at T2 [P = 0.012]). Dexmedetomidine 4-19 interferon gamma Homo sapiens 68-77 24441101-3 2014 alpha-NAC has been shown before to induce T-cell proliferation and secretion of IFN-gamma. alpha-nac 0-9 interferon gamma Homo sapiens 80-89 24441101-5 2014 Transcription and secretion of IFN-gamma, IL-17, and IL-22 were increased in alpha-NAC-stimulated PBMCs. alpha-nac 77-86 interferon gamma Homo sapiens 31-40 24114722-2 2014 Gag-specific responses were measured by IFN-gamma ELISpot. Glycosaminoglycans 0-3 interferon gamma Homo sapiens 40-49 24627407-12 2014 In contrast, levels of Th1 (interferon-gamma and IL-2) and regulatory cytokines (transforming growth factor-beta and IL-10) increased significantly after ASC treatment. asc 154-157 interferon gamma Homo sapiens 28-44 24038588-3 2014 The results showed that the JAK/STAT pathway activation by proinflammatory cytokine interleukin-6 and interferon-gamma in CCA cells was suppressed by pretreatment with quercetin and EGCG, evidently by a decrease of the elevated phosphorylated-STAT1 and STAT3 proteins in a dose-dependent manner. Quercetin 168-177 interferon gamma Homo sapiens 102-118 24038588-3 2014 The results showed that the JAK/STAT pathway activation by proinflammatory cytokine interleukin-6 and interferon-gamma in CCA cells was suppressed by pretreatment with quercetin and EGCG, evidently by a decrease of the elevated phosphorylated-STAT1 and STAT3 proteins in a dose-dependent manner. epigallocatechin gallate 182-186 interferon gamma Homo sapiens 102-118 24666466-10 2014 Analogous to CsA-treated CMV patients, the level of significance was reached for IFNgamma (61 +- 24 vs. 88 +- 29, P = 0.0154). Cyclosporine 13-16 interferon gamma Homo sapiens 81-89 24989262-7 2014 IFN-gamma stimulation up-regulated the expression of immunosuppressive genes like IDO1, COX2, HLA-G, and soluble suppressive proteins such as HLA-G, KYN, IL10, PGE2 of MSC. Dinoprostone 160-164 interferon gamma Homo sapiens 0-9 25177524-7 2014 Biliverdin (50 muM) significantly decreased the LPS-mediated gene expression of IL-1beta, IL-6, IFN-gamma, IL-1Ra and IL-8 (P<0.05). Biliverdine 0-10 interferon gamma Homo sapiens 96-105 24858101-9 2014 Furthermore, by using cytokine array analysis, we found that linalool can stimulate IFN-gamma, IL-13, IL-2, IL-21, IL-21R, IL-4, IL-6sR and TNF-alpha secretion. linalool 61-69 interferon gamma Homo sapiens 84-93 24891923-3 2014 We hypothesized that IFNgamma promoter methylation at two well-studied, key cytosine phosphate guanine (CpG) sites (-186 and -54), may differ by age, sex, and airway versus systemic tissue in a cohort of 74 allergic asthmatics. cytosine phosphate guanine 76-102 interferon gamma Homo sapiens 21-29 24845203-5 2014 Following the cell biology mechanisms, we develop a liquid photo-immobilization approach to attach doxorubicin, folic acid, tumor necrosis factor-alpha, and interferon-gamma onto the oleic acid molecules coated Fe3O4 magnetic nanoparticles to prepare a kind of novel inner/outer controlled multi-target magnetic nanoparticle drug carrier. Oleic Acid 183-193 interferon gamma Homo sapiens 157-173 24845203-5 2014 Following the cell biology mechanisms, we develop a liquid photo-immobilization approach to attach doxorubicin, folic acid, tumor necrosis factor-alpha, and interferon-gamma onto the oleic acid molecules coated Fe3O4 magnetic nanoparticles to prepare a kind of novel inner/outer controlled multi-target magnetic nanoparticle drug carrier. ferryl iron 211-216 interferon gamma Homo sapiens 157-173 24847715-5 2014 The substitution of alanine for this residue completely abolished both binding to high-affinity GAS elements and transcriptional activation of endogenous target genes in cells stimulated with interferon-gamma (IFNgamma), while the time course of transient nuclear accumulation and tyrosine phosphorylation were virtually unchanged. Alanine 20-27 interferon gamma Homo sapiens 192-208 24847715-5 2014 The substitution of alanine for this residue completely abolished both binding to high-affinity GAS elements and transcriptional activation of endogenous target genes in cells stimulated with interferon-gamma (IFNgamma), while the time course of transient nuclear accumulation and tyrosine phosphorylation were virtually unchanged. Alanine 20-27 interferon gamma Homo sapiens 210-218 24847715-6 2014 In contrast, two glutamic acid residues (E559 and E563) on each monomer are important for the dissociation of dimeric STAT1 from DNA and, when mutated to alanine, result in elevated levels of tyrosine-phosphorylated STAT1 as well as prolonged IFNgamma-stimulated nuclear accumulation. Glutamic Acid 17-30 interferon gamma Homo sapiens 243-251 24847715-6 2014 In contrast, two glutamic acid residues (E559 and E563) on each monomer are important for the dissociation of dimeric STAT1 from DNA and, when mutated to alanine, result in elevated levels of tyrosine-phosphorylated STAT1 as well as prolonged IFNgamma-stimulated nuclear accumulation. Alanine 154-161 interferon gamma Homo sapiens 243-251 24847715-6 2014 In contrast, two glutamic acid residues (E559 and E563) on each monomer are important for the dissociation of dimeric STAT1 from DNA and, when mutated to alanine, result in elevated levels of tyrosine-phosphorylated STAT1 as well as prolonged IFNgamma-stimulated nuclear accumulation. Tyrosine 192-200 interferon gamma Homo sapiens 243-251 24849390-7 2014 The aptamer was also found capable of binding with paraformaldehyde-fixed IFN-gamma. paraform 51-67 interferon gamma Homo sapiens 74-83 24810615-8 2014 Following PZQ treatment there was an increase in the number of participants producing detectable levels of GST-specific cytokines (TNFalpha, IL-6, IL-8, IFNgamma, IL-12p70, IL-13 and IL-23p19) and also a shift in the GST-specific cytokine response towards a more pro-inflammatory phenotype than that observed before treatment. Praziquantel 10-13 interferon gamma Homo sapiens 153-161 24809379-0 2014 Theophylline attenuates the adhesiveness of endothelial cells augmented with interferon-gamma in the presence of TNF-alpha for blood eosinophils. Theophylline 0-12 interferon gamma Homo sapiens 77-93 24980231-9 2014 Sinus mucosa explant stimulated with LPA increasingly produced IL-4, IL-5, interferon gamma, and TNF-alpha, and in cultured epithelial cells stimulated with CRS-relevant cytokines, ATX, and LPA1-3 were differentially induced. lysophosphatidic acid 37-40 interferon gamma Homo sapiens 75-91 24704449-4 2014 The purpose of this study was to investigate the effect of (+)-nootkatone on tumor necrosis factor alpha (TNF-alpha)/interferon gamma (IFN-gamma)-induced expression of Th2 chemokines in HaCaT cells. nootkatone 59-73 interferon gamma Homo sapiens 117-144 24704449-5 2014 We found that (+)-nootkatone inhibited the TNF-alpha/IFN-gamma-induced expression of TARC/CCL17 and MDC/CCL22 mRNA in HaCaT cells. nootkatone 14-28 interferon gamma Homo sapiens 53-62 24704449-8 2014 Taken together, these results suggest that (+)-nootkatone may suppress TNF-alpha/IFN-gamma-induced TARC/CCL17 and MDC/CCL22 expression in HaCaT cells by inhibiting of PKCzeta and p38 MAPK signaling pathways that lead to activation of NF-kappaB. nootkatone 43-57 interferon gamma Homo sapiens 81-90 24583150-7 2014 The levels of serum IL-17A and IFN-gamma in steroid group and serum TNF-alpha in alcoholic group were significantly higher than those in the HC. Steroids 44-51 interferon gamma Homo sapiens 31-40 25050011-5 2014 However, the mRNA expression of interleukin (IL)-1beta, IL-6, interferon (IFN)-gamma, Toll like receptor (TLR)-4 and HSP70 in the liver of birds fed diet containing vitamin C significantly (p<0.05) decreased compared with those in birds fed basal diet. Ascorbic Acid 165-174 interferon gamma Homo sapiens 62-84 24732061-8 2014 With the stimulation of HS, the production of IL-4 and the FcalphaRI expressing cells in the IgA nephropathy group was significantly increased than the non-IgAN group, while the secretion of IFN-gamma was remarkably decreased in the IgA nephropathy group than the non-IgAN group. hassio 24-26 interferon gamma Homo sapiens 191-200 24569883-6 2014 Finally, we demonstrate that Rab20 interacts with the Rab5a guanine nucleotide exchange factor Rabex-5 (also known as RABGEF1) and that Rab20 knockdown impairs the IFN-gamma-dependent recruitment of Rabex-5 and Rab5a into phagosomes. Guanine Nucleotides 60-78 interferon gamma Homo sapiens 164-173 24683191-9 2014 IFN-gamma expression was reduced in all lupus T cell subsets (p = 1.0 x 10(-5)) and also resisted rapamycin. Sirolimus 98-107 interferon gamma Homo sapiens 0-9 24347277-3 2014 Replication-defective HSV-1 vector (rdHSV-IFNgamma) was established by calcium phosphate co-transfection of complementing cells. calcium phosphate 71-88 interferon gamma Homo sapiens 42-50 24482023-9 2014 IFN-gamma immunostaining correlated positively with serum creatinine and negatively with albumin levels and glomerular filtration rate (GFR). Creatinine 58-68 interferon gamma Homo sapiens 0-9 23612780-5 2014 However, 100 nM of vitamin D3 significantly increased the release of IL-10, but suppressed the production of IL-2, IL-6, interferon gamma and TNF alpha in the culture supernatants of both groups. Cholecalciferol 19-29 interferon gamma Homo sapiens 121-137 24430547-2 2014 As such, the current study investigates the use of aurintricarboxylic acid (ATA), which stimulates insulinlike growth factor 1 receptor and AKT signaling, for its ability to ameliorate the protein metabolic effects of endotoxin (lipopolysaccharide [LPS]) + interferon gamma (IFN-gamma) in C2C12 myotubes and sepsis in skeletal muscle. Aurintricarboxylic Acid 51-74 interferon gamma Homo sapiens 257-284 24430547-2 2014 As such, the current study investigates the use of aurintricarboxylic acid (ATA), which stimulates insulinlike growth factor 1 receptor and AKT signaling, for its ability to ameliorate the protein metabolic effects of endotoxin (lipopolysaccharide [LPS]) + interferon gamma (IFN-gamma) in C2C12 myotubes and sepsis in skeletal muscle. Aurintricarboxylic Acid 76-79 interferon gamma Homo sapiens 257-284 24621055-3 2014 The aim of the present study was to assess the association between diabetes and Mycobacterium tuberculosis (Mtb) antigen-specific interferon gamma (IFN-gamma) release in a TB endemic area among culture-confirmed TB patients and non-TB controls. Terbium 172-174 interferon gamma Homo sapiens 80-157 24621055-3 2014 The aim of the present study was to assess the association between diabetes and Mycobacterium tuberculosis (Mtb) antigen-specific interferon gamma (IFN-gamma) release in a TB endemic area among culture-confirmed TB patients and non-TB controls. Terbium 212-214 interferon gamma Homo sapiens 80-157 24621055-8 2014 Increasing levels of fasting blood glucose (B - 0.3, 95% confidence interval - 0.6 to - 0.03, p = 0.033) was negatively associated with IFN-gamma. Glucose 35-42 interferon gamma Homo sapiens 136-145 24621055-9 2014 Although TB patients had higher specific and lower unspecific mitogen IFN-gamma responses compared to non-TB controls, the association between diabetes and IFN-gamma did not depend on TB status. Terbium 9-11 interferon gamma Homo sapiens 70-79 24903009-2 2014 Indoleamine 2,3-dioxygenase 1 (IDO1) is an interferon (IFN)-gamma-inducible enzyme that degrades tryptophan into kynurenine, which, in turn, inhibits effector T cells and promotes regulatory T-cell (Treg) differentiation. Tryptophan 97-107 interferon gamma Homo sapiens 43-65 24759737-10 2014 Of interest was the down-regulation of miR-125a in PTSD, which specifically targeted IFN-gamma production. mir-125a 39-47 interferon gamma Homo sapiens 85-94 24903009-2 2014 Indoleamine 2,3-dioxygenase 1 (IDO1) is an interferon (IFN)-gamma-inducible enzyme that degrades tryptophan into kynurenine, which, in turn, inhibits effector T cells and promotes regulatory T-cell (Treg) differentiation. Kynurenine 113-123 interferon gamma Homo sapiens 43-65 24751900-2 2014 In vitro culture of PBMC with abacavir results in the outgrowth of abacavir-reacting CD8+ T cells, which release IFNgamma and are cytotoxic. abacavir 30-38 interferon gamma Homo sapiens 113-121 24751900-2 2014 In vitro culture of PBMC with abacavir results in the outgrowth of abacavir-reacting CD8+ T cells, which release IFNgamma and are cytotoxic. abacavir 67-75 interferon gamma Homo sapiens 113-121 24745366-1 2014 INTRODUCTION: Our objective was to assess the capacity of dendrimer aza-bis-phosphonate (ABP) to modulate phenotype of monocytes (Mo) and monocytes derived dendritic cells (MoDC) activated in response to toll-like receptor 4 (TLR4) and interferon gamma (IFN- gamma) stimulation. aza-bis-phosphonate 68-87 interferon gamma Homo sapiens 236-264 24745366-1 2014 INTRODUCTION: Our objective was to assess the capacity of dendrimer aza-bis-phosphonate (ABP) to modulate phenotype of monocytes (Mo) and monocytes derived dendritic cells (MoDC) activated in response to toll-like receptor 4 (TLR4) and interferon gamma (IFN- gamma) stimulation. abp 89-92 interferon gamma Homo sapiens 236-264 24694060-3 2014 FINDINGS: Using anti-CD3 antibody-stimulated human peripheral blood mononuclear cell cultures, we observed that Hsp90 inhibition by non-toxic concentrations of the geldanamycin derivative 17-DMAG significantly blocked T cell proliferation, reduced IFN-gamma and IL-17 expression on CD4+ T lymphocytes, and arrested secretion of proinflammatory IFN-gamma, TNF-alpha, and IL-17, cytokines characteristic of Th1 and Th17 cells, respectively. geldanamycin 164-176 interferon gamma Homo sapiens 248-257 24736562-4 2014 While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs. Poly I-C 6-13 interferon gamma Homo sapiens 81-89 24717973-4 2014 Treatment of MSCs with glucocorticoids, budesonide or dexamethasone, enhanced IDO expression following IFN-gamma stimulation in multiple donors and was able to restore IDO expression in over-passaged MSCs. Budesonide 40-50 interferon gamma Homo sapiens 103-112 24717973-4 2014 Treatment of MSCs with glucocorticoids, budesonide or dexamethasone, enhanced IDO expression following IFN-gamma stimulation in multiple donors and was able to restore IDO expression in over-passaged MSCs. Dexamethasone 54-67 interferon gamma Homo sapiens 103-112 24710174-10 2014 The IFN-gamma response of CBMCs to ESAT-6/CFP-10 cocktail (50 vs 116, p = 0.018) and PPD (58 vs 123, p = 0.02) was significantly lower in helminth positive than negative participants. cbmcs 26-31 interferon gamma Homo sapiens 4-13 24710174-12 2014 CONCLUSIONS: Maternal helminth infection had a significant association with the IFN-gamma response of CBMCs, total IgE and cross placental transfer of TB specific IgG. cbmcs 102-107 interferon gamma Homo sapiens 80-89 24694060-3 2014 FINDINGS: Using anti-CD3 antibody-stimulated human peripheral blood mononuclear cell cultures, we observed that Hsp90 inhibition by non-toxic concentrations of the geldanamycin derivative 17-DMAG significantly blocked T cell proliferation, reduced IFN-gamma and IL-17 expression on CD4+ T lymphocytes, and arrested secretion of proinflammatory IFN-gamma, TNF-alpha, and IL-17, cytokines characteristic of Th1 and Th17 cells, respectively. geldanamycin 164-176 interferon gamma Homo sapiens 344-353 24694060-3 2014 FINDINGS: Using anti-CD3 antibody-stimulated human peripheral blood mononuclear cell cultures, we observed that Hsp90 inhibition by non-toxic concentrations of the geldanamycin derivative 17-DMAG significantly blocked T cell proliferation, reduced IFN-gamma and IL-17 expression on CD4+ T lymphocytes, and arrested secretion of proinflammatory IFN-gamma, TNF-alpha, and IL-17, cytokines characteristic of Th1 and Th17 cells, respectively. 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin 188-195 interferon gamma Homo sapiens 248-257 24694060-3 2014 FINDINGS: Using anti-CD3 antibody-stimulated human peripheral blood mononuclear cell cultures, we observed that Hsp90 inhibition by non-toxic concentrations of the geldanamycin derivative 17-DMAG significantly blocked T cell proliferation, reduced IFN-gamma and IL-17 expression on CD4+ T lymphocytes, and arrested secretion of proinflammatory IFN-gamma, TNF-alpha, and IL-17, cytokines characteristic of Th1 and Th17 cells, respectively. 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin 188-195 interferon gamma Homo sapiens 344-353 24365239-10 2014 The CCh-induced ERK and FAK phosphorylation were also attenuated by the IFN-gamma treatment. Carbachol 4-7 interferon gamma Homo sapiens 72-81 24764577-8 2014 Moreover, the JAK1/2 inhibitor ruxolitinib potently inhibited the anti-CD3-dependent production of IFN-gamma, a marker of the differentiation of Th cells along the tumor-inhibitory Th1 pathway. ruxolitinib 31-42 interferon gamma Homo sapiens 99-108 24567316-4 2014 A significant decrease in TNF-alpha and interferon-gamma (IFN-gamma) levels during therapy was more pronounced in the antimony plus pentoxifylline group, whereas CCL-3 (Chemokine [C-C motif] ligand 3) decreased similarly in both groups. Pentoxifylline 132-146 interferon gamma Homo sapiens 40-56 24567316-4 2014 A significant decrease in TNF-alpha and interferon-gamma (IFN-gamma) levels during therapy was more pronounced in the antimony plus pentoxifylline group, whereas CCL-3 (Chemokine [C-C motif] ligand 3) decreased similarly in both groups. Pentoxifylline 132-146 interferon gamma Homo sapiens 58-67 23943055-7 2014 Using peripheral blood lymphocytes, we demonstrated that delphinidin increased the production of IL-2 and IFN-gamma and was inhibited by BTP2. delphinidin 57-68 interferon gamma Homo sapiens 106-115 24419251-5 2014 RESULTS: The IL-17A, IL-6, IL-22 and IFN-gamma were significantly reduced in a dose response after simvastatin treatment (50 muM, p = 0.0005; p < 0.0001; p < 0.02; p = 0.0005, respectively). Simvastatin 99-110 interferon gamma Homo sapiens 37-46 24526733-8 2014 RESULTS: We found that GM-CT-01 boosts cytotoxicity of CD8(+) TIL and their IFN-gamma secretion in a dose-dependent manner. gm-ct 23-28 interferon gamma Homo sapiens 76-85 24332681-4 2014 Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-gamma, IL-1alpha, TNF-alpha, IL-6) as well as anti-inflammatory (IL-10 and TGF-beta) cytokines. Silicon Dioxide 29-35 interferon gamma Homo sapiens 256-265 24481938-0 2014 An indeterminate result of QuantiFERON-TB Gold In-Tube for miliary tuberculosis due to a high level of IFN-gamma production. tb gold 39-46 interferon gamma Homo sapiens 103-112 24192715-7 2014 Sotrastaurin prevented TCR/CD28-induced T-cell activation and pro-inflammatory cytokine production, but preserved a stable Treg phenotype as evidenced by maintenance of suppressive capacity, high Foxp3 and CD25 expression, and lack of IL-17A and IFNgamma production. sotrastaurin 0-12 interferon gamma Homo sapiens 246-254 24192715-8 2014 Moreover, in both circulating and dermal psoriatic Treg, prone to rapid induction of IL-17, sotrastaurin enhanced Foxp3 expression and prevented IL-17A and IFNgamma production even when stimulated in the presence of the helper T 17-enhancing cytokines IL-1beta or IL-23. sotrastaurin 92-104 interferon gamma Homo sapiens 156-164 24213371-8 2014 Tofacitinib also inhibited the expression of IFN-gamma-inducible chemoattractants by keratinocytes, and IFN-gamma-inducible cell death of keratinocytes. tofacitinib 0-11 interferon gamma Homo sapiens 45-54 24812901-10 2014 CONCLUSIONS: These results indicated that there was imbalanced IFN-gamma/IL-4 ratio in the peripheral blood of pregnant women of GSYDS. gsyds 129-134 interferon gamma Homo sapiens 63-72 24681574-12 2014 IFN-gamma induction of senescence was attenuated by siRNAs against p21, Janus kinase 2 (JAK2) or signal transducer and activator of transcription 1 (STAT1), but not by JAK1 siRNA nor by p53 inhibitor pifithrin-alpha. pifithrin 200-215 interferon gamma Homo sapiens 0-9 24681574-13 2014 IFN-gamma treatment increased the accumulation of intracellular ROS in melanocytes, while ROS scavenger N-acetyl cysteine (NAC) effectively inhibited IFN-gamma induced p21 expression and melanocyte senescence. Reactive Oxygen Species 64-67 interferon gamma Homo sapiens 0-9 24681574-13 2014 IFN-gamma treatment increased the accumulation of intracellular ROS in melanocytes, while ROS scavenger N-acetyl cysteine (NAC) effectively inhibited IFN-gamma induced p21 expression and melanocyte senescence. Reactive Oxygen Species 90-93 interferon gamma Homo sapiens 150-159 24681574-13 2014 IFN-gamma treatment increased the accumulation of intracellular ROS in melanocytes, while ROS scavenger N-acetyl cysteine (NAC) effectively inhibited IFN-gamma induced p21 expression and melanocyte senescence. Acetylcysteine 104-121 interferon gamma Homo sapiens 150-159 24681574-13 2014 IFN-gamma treatment increased the accumulation of intracellular ROS in melanocytes, while ROS scavenger N-acetyl cysteine (NAC) effectively inhibited IFN-gamma induced p21 expression and melanocyte senescence. Acetylcysteine 123-126 interferon gamma Homo sapiens 150-159 24681574-14 2014 IL-6 and HSP-70 release was significantly induced by IFN-gamma treatment, which was largely inhibited by NAC. Acetylcysteine 105-108 interferon gamma Homo sapiens 53-62 24711695-3 2014 Pirfenidone is a multifunctional, orally available small molecule with anti-fibrotic, anti-inflammatory, and antioxidative activities, and has been shown to be a modulator of cytokines and growth factors, including TGF-beta1, TNF-alpha, bFGF, IFN-gamma, IL-1beta, and IL-18 in animal models. pirfenidone 0-11 interferon gamma Homo sapiens 243-252 24612598-15 2014 Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in osteosarcoma patients. l-mtp 72-77 interferon gamma Homo sapiens 90-99 24389051-0 2014 Significance of interferon-gamma response to mitogen in serial QuantiFERON-TB Gold In-Tube assay of routine laboratory practice. tb gold 75-82 interferon gamma Homo sapiens 16-32 24144556-1 2014 Present work describes the methylene blue tagged thiolated aptamer-modified gold micro-array based biosensor for specific detection of IFN-gamma. Methylene Blue 27-41 interferon gamma Homo sapiens 135-144 24717792-14 2014 The study confirms aspirin desensitization is effective clinically in AERD patients and suggests that IFN gamma and IL-10 expression in CD4(+) T lymphocytes may be related to the mechanism of action. Aspirin 19-26 interferon gamma Homo sapiens 102-111 24602288-11 2014 Rapamycin treatment significantly improved the neurobehavioral deficit after ICH, increased the number of Tregs, increased levels of interleukin-10 and transforming growth factor-beta and reduced interferon-gamma both in peripheral blood and brain. Sirolimus 0-9 interferon gamma Homo sapiens 196-212 24370834-8 2014 Moreover, IFN-gamma strongly upregulates MHC-II molecules and IDO activity in HCEC as reflected by high kynurenine (Kyn) concentrations. Kynurenine 104-114 interferon gamma Homo sapiens 10-19 24370834-8 2014 Moreover, IFN-gamma strongly upregulates MHC-II molecules and IDO activity in HCEC as reflected by high kynurenine (Kyn) concentrations. Kynurenine 116-119 interferon gamma Homo sapiens 10-19 24414257-3 2014 Here we show that IFN-gamma decreases ATP-mediated apical BK activation in normal human airway epithelial cells cultured at the air-liquid interface. Adenosine Triphosphate 38-41 interferon gamma Homo sapiens 18-27 24363024-7 2014 Adding lunasin to IL-12- or IL-2-stimulated NK cells demonstrated synergistic effects in the induction of IFNG and GZMB involved in cytotoxicity. LUNASINE 7-14 interferon gamma Homo sapiens 106-110 24414257-3 2014 Here we show that IFN-gamma decreases ATP-mediated apical BK activation in normal human airway epithelial cells cultured at the air-liquid interface. Berkelium 58-60 interferon gamma Homo sapiens 18-27 24414257-5 2014 Because IFN-gamma upregulates dual oxidase (DUOX)2 and therefore H2O2 production, we hypothesized that BK inactivation could be mediated by BK oxidation. Hydrogen Peroxide 65-69 interferon gamma Homo sapiens 8-17 24414257-8 2014 Mallotoxin, a BK opener only in the absence of LRRC26, showed that BK channels lost their association with LRRC26 after IFN-gamma treatment. rottlerin 0-10 interferon gamma Homo sapiens 120-129 23625984-10 2014 Dexamethasone downregulated pro-inflammatory mediator (IL-1beta, IL-6, TNFalpha, IFNgamma, MMP-9, TIMP-1, CCL3 and CXCL8) mRNAs but did not modify expression of vascular remodelling factors (platelet derived growth factor, MMP-2 and collagens I and III). Dexamethasone 0-13 interferon gamma Homo sapiens 81-89 24135768-4 2014 RESULTS: IFN-gamma levels declined between baseline and the end of IPT (signed rank test P<=.0001) and between baseline and a similar period of observation without IPT (signed rank test P=.03). isoprothiolane 67-70 interferon gamma Homo sapiens 9-18 24464647-7 2014 We examined intracellular ERK1/2 phosphorylation and IFN-gamma production by CD4+ and CD8+ T cells upon polyclonal stimulation with PMA and ionomycin, while monitoring expression of the cytolytic molecule perforin and the T cell activation marker CD38. Tetradecanoylphorbol Acetate 132-135 interferon gamma Homo sapiens 53-62 24440806-7 2014 Finally, we demonstrated that IFN-gamma production of MEIOB peptide-specific helper T cells in response to HLA-matched cancer cells was greatly augmented by treatment with DAC and IFN-gamma. Decitabine 172-175 interferon gamma Homo sapiens 30-39 24548422-7 2014 Elevated levels of TNF-alpha, interleukin (IL)-6, IL-1beta, interferon (IFN)-gamma and IL-17 were observed during DSS exposure phase which restored to the normal level after DSS removal. Dextran Sulfate 114-117 interferon gamma Homo sapiens 60-82 24398649-0 2014 Effect of vitamin D supplementation on cathelicidin, IFN-gamma, IL-4 and Th1/Th2 transcription factors in young healthy females. Vitamin D 10-19 interferon gamma Homo sapiens 53-62 24831405-0 2014 Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-gamma/IL-12 pathway defect. Rifampin 57-65 interferon gamma Homo sapiens 128-137 24518112-3 2014 Further, they demonstrate that interferon gamma decreases the expression of the enzymes required for the synthesis of these ultra long-chain ceramides (ELOVLs and ceramide synthase 3). Ceramides 141-150 interferon gamma Homo sapiens 31-47 24008422-0 2014 Interferon-gamma decreases ceramides with long-chain fatty acids: possible involvement in atopic dermatitis and psoriasis. Ceramides 27-36 interferon gamma Homo sapiens 0-16 24008422-0 2014 Interferon-gamma decreases ceramides with long-chain fatty acids: possible involvement in atopic dermatitis and psoriasis. long-chain fatty acids 42-64 interferon gamma Homo sapiens 0-16 24008422-6 2014 Using cultured human keratinocytes and epidermal sheets, we found that only IFN-gamma among various cytokines decreased the mRNA expression of elongase of long-chain fatty acids (ELOVL) and ceramide synthase (CerS), enzymes involved in FA chain elongation. long-chain fatty acids 155-177 interferon gamma Homo sapiens 76-85 24008422-8 2014 These results suggest that IFN-gamma decreases CERs with long-chain FAs through the downregulation of ELOVL and CerS and that this mechanism may be involved in the CER profile alteration observed in psoriasis and AD. Fatty Acids 68-71 interferon gamma Homo sapiens 27-36 24518112-4 2014 These results suggest that an increase in interferon gamma by decreasing the key enzymes required for the synthesis of ultra long-chain ceramides could further impair permeability barrier function, thereby exacerbating the pathological changes. Ceramides 136-145 interferon gamma Homo sapiens 42-58 24246020-7 2014 After being co-cultured with Phorbol 12-myristate 13-acetate, ionomycin and monensin, the expression level of interferon (IFN)-gamma in the dNK cells was detected by FCM. Tetradecanoylphorbol Acetate 29-60 interferon gamma Homo sapiens 110-132 24439748-8 2014 RESULTS: Incubating endothelial cells with TNF-alpha, IFN-gamma, and PBMCs increased cell elongation, gap formation, and subsequently the permeability of fluorescein isothiocyanate-labeled bovine serum albumin compared with control or TNF-alpha and IFN-gamma-treated cells (P < .05). Fluorescein-5-isothiocyanate 154-180 interferon gamma Homo sapiens 54-63 24418375-3 2014 beta-glucan attenuated CD86 and CD80 expression and simultaneously reduced secretion of the inflammatory cytokines IL-2, IL-8, IL-12, TNF-alpha and IFN-gamma. beta-Glucans 0-11 interferon gamma Homo sapiens 148-157 24439748-8 2014 RESULTS: Incubating endothelial cells with TNF-alpha, IFN-gamma, and PBMCs increased cell elongation, gap formation, and subsequently the permeability of fluorescein isothiocyanate-labeled bovine serum albumin compared with control or TNF-alpha and IFN-gamma-treated cells (P < .05). Fluorescein-5-isothiocyanate 154-180 interferon gamma Homo sapiens 249-258 24380732-8 2014 Bortezomib also inhibited the pro-fibrotic (VEGF, HGF, bFGF, TGF-beta) and pro-inflammatory (IL-1beta, TNF-alpha and IFN-gamma) cytokines significantly in comparison to untreated animals with I/R injury. Bortezomib 0-10 interferon gamma Homo sapiens 117-126 24309183-7 2014 Upon exposure to IFN-gamma, TNF-alpha, or IL-1beta, TEERs declined in dexamethasone-treated cells but remained consistently higher than in cells not receiving glucocorticoids. Dexamethasone 70-83 interferon gamma Homo sapiens 17-26 24391115-7 2014 Activation of ERKs by IFNgamma and TNFalpha also affected STAT1 and NF-kappaB signaling through modulation of serine phosphorylation. Serine 110-116 interferon gamma Homo sapiens 22-30 24391115-8 2014 ERK activation-induced serine phosphorylation of both STAT1 and p65 mediated the additive effects of IFNgamma and TNFalpha on LCN2 expression. Serine 23-29 interferon gamma Homo sapiens 101-109 24342979-7 2014 RESULTS: Cyclosporine A and tacrolimus significantly reduced IFNgamma production in a dose-dependent manner (53%-83%), but showed minimal effect on degranulation (20%). Cyclosporine 9-23 interferon gamma Homo sapiens 61-69 24342979-7 2014 RESULTS: Cyclosporine A and tacrolimus significantly reduced IFNgamma production in a dose-dependent manner (53%-83%), but showed minimal effect on degranulation (20%). Tacrolimus 28-38 interferon gamma Homo sapiens 61-69 24342979-8 2014 Prednisone significantly reduced both IFNgamma production and degranulation (50%-66% reduction at maximum therapeutic levels). Prednisone 0-10 interferon gamma Homo sapiens 38-46 24342979-9 2014 Calcineurin inhibitors (CNIs) in combination with prednisone additively suppressed IFNgamma production and degranulation. Prednisone 50-60 interferon gamma Homo sapiens 83-91 24394748-9 2014 On biopsies from treated CD patients, serotonin upregulated IFN-gamma production at levels comparable to those induced by PT-gliadin. Serotonin 38-47 interferon gamma Homo sapiens 60-69 23905758-6 2014 NFAT inhibition with either cyclosporin or Synta 66 resulted in significantly greater maximal inhibition of cytokines than dexamethasone in both peripheral blood and pulmonary CD8 cells [e.g. >95% inhibition of IFNgamma (interferon gamma) production from pulmonary CD8 cells using cyclosporin and Synta 66 compared with <50% using dexamethasone]. synta 43-48 interferon gamma Homo sapiens 214-222 24394748-13 2014 IFN-gamma upregulation induced by serotonin suggests that this monoamine may have a role in sustaining the local inflammatory response in CD. Serotonin 34-43 interferon gamma Homo sapiens 0-9 24394748-13 2014 IFN-gamma upregulation induced by serotonin suggests that this monoamine may have a role in sustaining the local inflammatory response in CD. monoamine 63-72 interferon gamma Homo sapiens 0-9 24287278-11 2014 Furthermore, FK866 promoted tubular cell apoptosis in an inflammatory milieu containing the cytokines TNFalpha/IFNgamma. N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 13-18 interferon gamma Homo sapiens 111-119 23905758-6 2014 NFAT inhibition with either cyclosporin or Synta 66 resulted in significantly greater maximal inhibition of cytokines than dexamethasone in both peripheral blood and pulmonary CD8 cells [e.g. >95% inhibition of IFNgamma (interferon gamma) production from pulmonary CD8 cells using cyclosporin and Synta 66 compared with <50% using dexamethasone]. synta 43-48 interferon gamma Homo sapiens 224-240 24313624-7 2014 Following cholecalciferol intake, the frequencies of circulating CD38 expressing B cells were significantly increased and IFN-gamma+ , and/or IL-17+ CD4+ T helper cells were decreased. Cholecalciferol 10-25 interferon gamma Homo sapiens 122-131 24184133-12 2014 Induction of Ifng was reduced after administration of an inhibitor of natural killer cell function (anti-asialo GM1). G(M1) Ganglioside 112-115 interferon gamma Homo sapiens 13-17 24368122-0 2014 In vitro activation of mouse neutrophils by recombinant human interferon-gamma: increased phagocytosis and release of reactive oxygen species and pro-inflammatory cytokines. Reactive Oxygen Species 118-141 interferon gamma Homo sapiens 62-78 24497216-9 2014 Serum interferon gamma (IFNgamma) concentration was significantly (p < 0.05) correlated with TB BMD (r = 0.36), TB BMC (r = 0.38) and TB BMC for height (r = 0.53) in the broader overweight group (n = 38). tb bmc 115-121 interferon gamma Homo sapiens 6-33 24060108-4 2014 Treatment with pro-inflammatory cytokines mainly tumor necrosis factor-alpha, interleukin 1-beta, and interferon-gamma induces an increase in inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production. Nitric Oxide 152-164 interferon gamma Homo sapiens 102-118 23999600-10 2014 gp120-expanded CD33(+) MDSCs inhibited IFN-gamma release from autologous T cells, which was restored upon ROS and iNOS inhibition. Reactive Oxygen Species 106-109 interferon gamma Homo sapiens 39-48 24253448-4 2014 Following 96 h of methanol induction, Tricine-SDS-PAGE Coomassie staining, western blot analysis and N-terminal protein sequencing revealed that the level of recombinant hIFN-gamma (rhIFN-gamma) secreted by the native secretion signal was barely detectable, while the alpha signal peptide secreted ~300 mg/l. Methanol 18-26 interferon gamma Homo sapiens 170-193 24253448-4 2014 Following 96 h of methanol induction, Tricine-SDS-PAGE Coomassie staining, western blot analysis and N-terminal protein sequencing revealed that the level of recombinant hIFN-gamma (rhIFN-gamma) secreted by the native secretion signal was barely detectable, while the alpha signal peptide secreted ~300 mg/l. Tricine SDS 38-49 interferon gamma Homo sapiens 170-193 24253448-4 2014 Following 96 h of methanol induction, Tricine-SDS-PAGE Coomassie staining, western blot analysis and N-terminal protein sequencing revealed that the level of recombinant hIFN-gamma (rhIFN-gamma) secreted by the native secretion signal was barely detectable, while the alpha signal peptide secreted ~300 mg/l. coomassie 55-64 interferon gamma Homo sapiens 170-193 24497216-9 2014 Serum interferon gamma (IFNgamma) concentration was significantly (p < 0.05) correlated with TB BMD (r = 0.36), TB BMC (r = 0.38) and TB BMC for height (r = 0.53) in the broader overweight group (n = 38). tb bmc 137-143 interferon gamma Homo sapiens 6-33 24067141-2 2014 Though Ca(2+) signaling is of particular significance in sperm, the effect of IFN-gamma intracellular calcium on these cells is still unknown. Calcium 102-109 interferon gamma Homo sapiens 78-87 24036099-4 2014 More importantly, GM-bilosomes were found capable of inducing mucosal immune response, i.e. sIgA titre in salivary and intestinal secretions as well as cell mediated immune response (IL-2 and IFN-gamma levels in spleen homogenate) which was not induced by i.m. gm 18-20 interferon gamma Homo sapiens 192-201 24036099-4 2014 More importantly, GM-bilosomes were found capable of inducing mucosal immune response, i.e. sIgA titre in salivary and intestinal secretions as well as cell mediated immune response (IL-2 and IFN-gamma levels in spleen homogenate) which was not induced by i.m. bilosomes 21-30 interferon gamma Homo sapiens 192-201 24396448-0 2014 Adenovirus-mediated delivery of the human IFN-gamma gene potentiates the cytotoxicity of daunorubicin against leukemic cells through downregulation of the alpha4beta1 integrin/ILK/apoptosis pathway. Daunorubicin 89-101 interferon gamma Homo sapiens 42-51 24067141-9 2014 This alteration induced by IFN-gamma was prevented by the simultaneous incubation of sperm with the antioxidant butylhydroxytoluene (BHT). Butylated Hydroxytoluene 112-131 interferon gamma Homo sapiens 27-36 24067141-9 2014 This alteration induced by IFN-gamma was prevented by the simultaneous incubation of sperm with the antioxidant butylhydroxytoluene (BHT). Butylated Hydroxytoluene 133-136 interferon gamma Homo sapiens 27-36 24299844-3 2014 Our results demonstrated that polysaccharides markedly promoted the cytotoxicity of NK cells by enhancing IFN-gamma and perforin secretion and increasing the expression of the activating receptor NKp30 under normal conditions. Polysaccharides 30-45 interferon gamma Homo sapiens 106-115 24360828-1 2014 RCAI-147 is one of the hydroxylated analogues of KRN7000 which is known as a ligand for the activation of CD1d mediated invariant natural killer T cells (iNKT cells) and releases both T helper 1 (Th1) cytokines such as IFN-gamma and T helper 2 (Th2) cytokines such as IL-4. rcai-147 0-8 interferon gamma Homo sapiens 219-228 24360828-1 2014 RCAI-147 is one of the hydroxylated analogues of KRN7000 which is known as a ligand for the activation of CD1d mediated invariant natural killer T cells (iNKT cells) and releases both T helper 1 (Th1) cytokines such as IFN-gamma and T helper 2 (Th2) cytokines such as IL-4. KRN 7000 49-56 interferon gamma Homo sapiens 219-228 24418325-0 2014 Interferon-gamma-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines. Bortezomib 85-95 interferon gamma Homo sapiens 0-16 24275061-2 2014 Here, we showed that DC cultures stimulated with low-level IFNgamma released exosomes (IFNgamma-DC-Exos) that contained microRNA species that can increase baseline myelination, reduce oxidative stress, and improve remyelination following acute lysolecithin-induced demyelination. Lysophosphatidylcholines 244-256 interferon gamma Homo sapiens 59-67 24275061-2 2014 Here, we showed that DC cultures stimulated with low-level IFNgamma released exosomes (IFNgamma-DC-Exos) that contained microRNA species that can increase baseline myelination, reduce oxidative stress, and improve remyelination following acute lysolecithin-induced demyelination. Lysophosphatidylcholines 244-256 interferon gamma Homo sapiens 87-95 24418325-3 2014 Here we investigated whether up-regulation of immunoproteasomes by exposure to interferon-gamma restores sensitivity to bortezomib in myeloma and leukemia cell lines with acquired resistance to bortezomib. Bortezomib 120-130 interferon gamma Homo sapiens 79-95 24418325-7 2014 RESULTS: Interferon-gamma exposure markedly increased immunoproteasome subunit mRNA to a significantly higher level in bortezomib-resistant cells (up to 30-fold, 10-fold, and 6-fold, in beta1i, beta5i, and beta2i, respectively) than in parental cells. Bortezomib 119-129 interferon gamma Homo sapiens 9-25 24418325-9 2014 Moreover, interferon-gamma exposure reinforced sensitization of bortezomib-resistant tumor cells to bortezomib and carfilzomib, but most prominently to ONX 0914, as confirmed by cell growth inhibition studies, proteasome inhibitor-induced apoptosis, activation of PARP cleavage and accumulation of polyubiquitinated proteins. Bortezomib 64-74 interferon gamma Homo sapiens 10-26 24418325-9 2014 Moreover, interferon-gamma exposure reinforced sensitization of bortezomib-resistant tumor cells to bortezomib and carfilzomib, but most prominently to ONX 0914, as confirmed by cell growth inhibition studies, proteasome inhibitor-induced apoptosis, activation of PARP cleavage and accumulation of polyubiquitinated proteins. Bortezomib 100-110 interferon gamma Homo sapiens 10-26 24418325-9 2014 Moreover, interferon-gamma exposure reinforced sensitization of bortezomib-resistant tumor cells to bortezomib and carfilzomib, but most prominently to ONX 0914, as confirmed by cell growth inhibition studies, proteasome inhibitor-induced apoptosis, activation of PARP cleavage and accumulation of polyubiquitinated proteins. carfilzomib 115-126 interferon gamma Homo sapiens 10-26 24418325-9 2014 Moreover, interferon-gamma exposure reinforced sensitization of bortezomib-resistant tumor cells to bortezomib and carfilzomib, but most prominently to ONX 0914, as confirmed by cell growth inhibition studies, proteasome inhibitor-induced apoptosis, activation of PARP cleavage and accumulation of polyubiquitinated proteins. PR-957 152-160 interferon gamma Homo sapiens 10-26 24418325-11 2014 CONCLUSION: Downregulation of beta5i subunit expression is a major determinant in acquisition of bortezomib-resistance and enhancement of its proteasomal assembly after induction by interferon-gamma facilitates restoration of sensitivity in bortezomib-resistant leukemia cells towards bortezomib and next generation (immuno) proteasome inhibitors. Bortezomib 241-251 interferon gamma Homo sapiens 182-198 24418325-11 2014 CONCLUSION: Downregulation of beta5i subunit expression is a major determinant in acquisition of bortezomib-resistance and enhancement of its proteasomal assembly after induction by interferon-gamma facilitates restoration of sensitivity in bortezomib-resistant leukemia cells towards bortezomib and next generation (immuno) proteasome inhibitors. Bortezomib 241-251 interferon gamma Homo sapiens 182-198 24575118-9 2014 We also demonstrate that IFN-gamma, but not the other stimuli, reduces the proliferation of cycloheximide-primed HK2 cells without affecting their viability. Cycloheximide 92-105 interferon gamma Homo sapiens 25-34 24171445-6 2014 However, significantly higher levels of IFN-gamma were induced by DDA:TDB liposomes, and liposome uptake by macrophages in vitro was also shown to be higher for DDA:TDB liposomes compared to their cholesterol-containing counterparts, suggesting that small changes in bilayer mechanics can impact both cellular interactions and immune responses. dimethyldioctadecylammonium 66-69 interferon gamma Homo sapiens 40-49 23085509-5 2014 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is a co-factor for several aromatic amino acid mono-oxygenases and is rate-limiting for the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). sapropterin 78-105 interferon gamma Homo sapiens 30-46 23085509-5 2014 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is a co-factor for several aromatic amino acid mono-oxygenases and is rate-limiting for the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). sapropterin 107-110 interferon gamma Homo sapiens 30-46 23085509-5 2014 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is a co-factor for several aromatic amino acid mono-oxygenases and is rate-limiting for the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). Serotonin 248-257 interferon gamma Homo sapiens 30-46 23085509-5 2014 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is a co-factor for several aromatic amino acid mono-oxygenases and is rate-limiting for the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). Dopamine 281-289 interferon gamma Homo sapiens 30-46 23085509-5 2014 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is a co-factor for several aromatic amino acid mono-oxygenases and is rate-limiting for the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). Epinephrine 291-302 interferon gamma Homo sapiens 30-46 23085509-5 2014 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is a co-factor for several aromatic amino acid mono-oxygenases and is rate-limiting for the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). Epinephrine 304-314 interferon gamma Homo sapiens 30-46 23085509-5 2014 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is a co-factor for several aromatic amino acid mono-oxygenases and is rate-limiting for the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). Norepinephrine 320-334 interferon gamma Homo sapiens 30-46 23085509-5 2014 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is a co-factor for several aromatic amino acid mono-oxygenases and is rate-limiting for the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). Norepinephrine 336-349 interferon gamma Homo sapiens 30-46 23085509-6 2014 Interferon-gamma triggers the high output of reactive oxygen species in macrophages, which can destroy the oxidation-labile BH4. Reactive Oxygen Species 45-68 interferon gamma Homo sapiens 0-16 23085509-6 2014 Interferon-gamma triggers the high output of reactive oxygen species in macrophages, which can destroy the oxidation-labile BH4. sapropterin 124-127 interferon gamma Homo sapiens 0-16 24717871-10 2014 NaHS induced increased expression of IL-4, IL-5, interferon gamma, and TNF-alpha. sodium bisulfide 0-4 interferon gamma Homo sapiens 49-65 24232001-5 2014 Pre- and coadministration of paeoniflorin significantly reduced the severity of colitis and resulted in downregulation of several inflammatory parameters in the colon, including the activity of myeloperoxidase (MPO), the levels of TNF-alpha and IL-6, and the mRNA expression of proinflammatory mediators (MCP-1, Cox2, IFN-gamma, TNF-alpha, IL-6, and IL-17). peoniflorin 29-41 interferon gamma Homo sapiens 318-327 25292102-4 2014 Our findings indicated that IFN-gamma treatment caused a time-dependent reduction in cell viability and induced apoptosis through a FADD-mediated caspase-8/tBid/mitochondria-dependent pathway in both cell lines. tBID 156-160 interferon gamma Homo sapiens 28-37 25292102-6 2014 In addition, inhibition of IDO activity by the IDO inhibitor 1-MT or tryptophan significantly reduced IFN-gamma-induced apoptosis and death receptor 5 (DR5) expression, which suggests that IDO enzymatic activity plays an important role in the anti-NSCLC cancer effect of IFN-gamma. Tryptophan 69-79 interferon gamma Homo sapiens 102-111 25292102-6 2014 In addition, inhibition of IDO activity by the IDO inhibitor 1-MT or tryptophan significantly reduced IFN-gamma-induced apoptosis and death receptor 5 (DR5) expression, which suggests that IDO enzymatic activity plays an important role in the anti-NSCLC cancer effect of IFN-gamma. Tryptophan 69-79 interferon gamma Homo sapiens 271-280 24099705-5 2014 Exposing SiO2@LDH nanoparticles to macrophages caused a higher dose-dependent expression of IFN-gamma, IL-6, CD86 and MHC II, compared with SiO2 and LDH respectively. Silicon Dioxide 9-13 interferon gamma Homo sapiens 92-101 25081699-9 2014 RESULTS: The expression of B7-H1 was significantly upregulated in monocyte-derived macrophages treated with rIL-12 or Ad-IL-12-GFP compared with the control groups (p<0.05), accompanied by a remarkable upregulation of IFN-gamma (p<0.05), a marked downregulation of IL-10 (p<0.05) and activation of NF-kappaB signaling. ril-12 108-114 interferon gamma Homo sapiens 221-230 24099705-5 2014 Exposing SiO2@LDH nanoparticles to macrophages caused a higher dose-dependent expression of IFN-gamma, IL-6, CD86 and MHC II, compared with SiO2 and LDH respectively. Silicon Dioxide 140-144 interferon gamma Homo sapiens 92-101 25032222-4 2014 The inhibitory effects of silibinin on ICAM-1 expression were mediated via the blockage of nuclear translocation of p65 proteins in TNF-alpha and phosphorylation of STAT1 in IFN-gamma-stimulated cells. Silybin 26-35 interferon gamma Homo sapiens 174-183 24587999-8 2014 In contrast, the presentation of KMP-11 antigen by DCs to T-lymphocytes in VL patients significantly increased the IFN-gamma produced by these immune cells, whereas the levels of IL-10 were significantly elevated after presentation of KMP-11 antigen by MPhis. kmp-11 33-39 interferon gamma Homo sapiens 115-124 23811849-7 2014 DEN and anthracyclines synergized to induce intratumoral accumulation of interferon-gamma-producing CD4(+) and CD8(+) T lymphocytes. Diethylnitrosamine 0-3 interferon gamma Homo sapiens 73-89 23941496-4 2014 Larifan caused strong induction of chemokine macrophage inflammatory protein 1beta, I-309, and TARC, proinflammatory cytokines IL-6, tumor necrosis factor -alpha, granulocyte macrophage colony-stimulating factor, anti-inflammatory IL-10, and cellular immunity mediating factors IL-23 and interferon-gamma. larifan 0-7 interferon gamma Homo sapiens 288-304 23933765-5 2014 CD45RA-depleted LPs contained effector and central memory CD4(+) and CD8(+) T cells that showed sustained IFN-gamma secretion to CMV, EBV, Aspergillus and Candida Ags. lps 16-19 interferon gamma Homo sapiens 106-115 23811849-7 2014 DEN and anthracyclines synergized to induce intratumoral accumulation of interferon-gamma-producing CD4(+) and CD8(+) T lymphocytes. Anthracyclines 8-22 interferon gamma Homo sapiens 73-89 25382321-13 2014 Furthermore, compared with those of PBMCs group, in vitro study indicated that Jurkat cells of H2S group expressed IFN-gamma, IL-10, IL-4 and IL-2 protein increased obviously (P < 0.05), while IL-4, IL-2 and CSE expression of PPG group decreased markedly (P < 0.05). Hydrogen Sulfide 95-98 interferon gamma Homo sapiens 115-124 24200969-9 2014 We experimentally showed that TNFalpha, EGFR, IFNalpha, and IFNgamma pathway activities were also upregulated in melanoma cell A375 compared with its sub-line DRO, while DRO was much more sensitive to AZD6244 than A375. AZD 6244 201-208 interferon gamma Homo sapiens 60-68 26155135-3 2014 The results showed that both DEX and CsA dose-dependently inhibited the production of eleven cytokines: interleukin (IL)-2, IL-4, IL-5, IL-6, IL-13, IL-17, interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). Dexamethasone 29-32 interferon gamma Homo sapiens 156-183 26155135-3 2014 The results showed that both DEX and CsA dose-dependently inhibited the production of eleven cytokines: interleukin (IL)-2, IL-4, IL-5, IL-6, IL-13, IL-17, interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). Cyclosporine 37-40 interferon gamma Homo sapiens 156-183 25056541-5 2014 Here we demonstrate that the frequency of Th17 and Th1 cells along with the relevant cytokines IL-17, IFN-gamma and corresponding transcriptional factors RORC, T-bet were all decreased following LXR activation by the agonist GW3965. GW 3965 225-231 interferon gamma Homo sapiens 102-111 24416783-8 2014 TNF-alpha, IL-6 and IFN-gamma had significant positive correlation with viral load, serum bilirubin and prothrombin time in pregnant women. Bilirubin 90-99 interferon gamma Homo sapiens 20-29 24434865-6 2014 All three immunosuppressive drugs inhibited the production of IL-2 equally well, whereas the production of IFN-gamma was less well inhibited by rapamycin. Sirolimus 144-153 interferon gamma Homo sapiens 107-116 25401758-0 2014 Bilberry-derived anthocyanins prevent IFN-gamma-induced pro-inflammatory signalling and cytokine secretion in human THP-1 monocytic cells. Anthocyanins 17-29 interferon gamma Homo sapiens 38-47 25524382-3 2014 RESULTS: Trichophytin or candidin, or both, stimulated the production of regulatory cytokines (TGF-beta and/or IL-10), accompanied or not by stimulation of production of cytokines associated with the Th1 response (TNF-alpha, IL-12 and IFN-gamma), but without stimulation of Th2 cytokines (IL-5 and IL-13) and IL-17, by peripheral blood mononuclear cells of most allergic and nonallergic individuals. candidin 25-33 interferon gamma Homo sapiens 235-244 24720535-8 2014 LLT with S and S+E reduced MCP-1 levels (P < 0 01 by anova) and IFNgamma levels (P < 0 01) in DM-CKD patients but not in DM-only patients. Sulfur 9-10 interferon gamma Homo sapiens 67-75 24720535-8 2014 LLT with S and S+E reduced MCP-1 levels (P < 0 01 by anova) and IFNgamma levels (P < 0 01) in DM-CKD patients but not in DM-only patients. Sulfur 15-16 interferon gamma Homo sapiens 67-75 23768082-7 2014 It was concluded that IFNgamma has favorable effects on the quality-of-life and alleviates respiratory symptoms in patients suffering from chronic SM-induced pulmonary complications. Mustard Gas 147-149 interferon gamma Homo sapiens 22-30 24010824-0 2014 DMOG ameliorates IFN-gamma-induced intestinal barrier dysfunction by suppressing PHD2-dependent HIF-1alpha degradation. dimethyloxallyl glycine 0-4 interferon gamma Homo sapiens 17-26 25371908-6 2014 The release of the cytokines remained stable after 30 mins except for IFNgamma, which showed a decrease in the controls following levofloxacin instillation. Levofloxacin 130-142 interferon gamma Homo sapiens 70-78 24010824-10 2014 Study also showed that DMOG reversed the IFN-gamma-induced decrease in HIF-1alpha protein expression. dimethyloxallyl glycine 23-27 interferon gamma Homo sapiens 41-50 23573828-4 2014 Prolonged lenalidomide treatment enhanced NK cell effector functions, and dasatinib addition at late stages of NK cell expansion increased levels of CD107a/b and interferon-gamma (IFNgamma), but not of tumor necrosis factor-alpha (TNFalpha). Dasatinib 74-83 interferon gamma Homo sapiens 162-178 25328518-5 2014 Mancozeb induced dose-dependent increases in lymphocyte proliferation, inhibition of production of TNFalpha and the TH2 cytokines IL-6 and IL-10, and an increase in IFNgamma (TH1 cytokine) production (at least 2-fold compared to control); mancozeb also induced inhibition of IL-4 (TH2) and stimulated IL-2 (TH1) production, albeit only in dose-related manners for each. mancozeb 0-8 interferon gamma Homo sapiens 165-173 23573828-4 2014 Prolonged lenalidomide treatment enhanced NK cell effector functions, and dasatinib addition at late stages of NK cell expansion increased levels of CD107a/b and interferon-gamma (IFNgamma), but not of tumor necrosis factor-alpha (TNFalpha). Dasatinib 74-83 interferon gamma Homo sapiens 180-188 24523572-9 2014 Moreover, pretreatment of cells with IFN-gamma upregulated CD40 receptor, which enabled HPFB to respond to a recombinant ligand of CD40 (CD40L). hpfb 88-92 interferon gamma Homo sapiens 37-46 24523572-10 2014 Exposure of IFN-gamma-treated HPFB, but not of control cells, to CD40L resulted in a dose-dependent induction of CCL5. hpfb 30-34 interferon gamma Homo sapiens 12-21 24706270-8 2014 By stimulation of PBMCs with PMA/ionomycin for 6 h, more than 1-2 % of total CD8 T cells are identified as positive in terms of multifunctionality, thus producing multiple cytokines--IL-2, TNFalpha, and IFNgamma--at single-cell level in case of all healthy donors. Tetradecanoylphorbol Acetate 29-32 interferon gamma Homo sapiens 203-211 24190972-3 2014 In those T cells, calcium signaling triggers the expression of Tle4, a member of the Groucho family of corepressors, which is then recruited to a distal regulatory element in the Ifng locus and causes the establishment of repressive epigenetic marks at the Ifng gene regulatory elements. Calcium 18-25 interferon gamma Homo sapiens 179-183 24190972-3 2014 In those T cells, calcium signaling triggers the expression of Tle4, a member of the Groucho family of corepressors, which is then recruited to a distal regulatory element in the Ifng locus and causes the establishment of repressive epigenetic marks at the Ifng gene regulatory elements. Calcium 18-25 interferon gamma Homo sapiens 257-261 24706270-8 2014 By stimulation of PBMCs with PMA/ionomycin for 6 h, more than 1-2 % of total CD8 T cells are identified as positive in terms of multifunctionality, thus producing multiple cytokines--IL-2, TNFalpha, and IFNgamma--at single-cell level in case of all healthy donors. Ionomycin 33-42 interferon gamma Homo sapiens 203-211 24995119-1 2014 This study was designed to investigate the relationship between NO, IL-12, and TNF-alpha production by J774A.1 macrophages activated with LPS and IFN-gamma in the presence of N-[3-(aminomethyl)benzyl]acetamidine (1400 W). N-(3-(aminomethyl)benzyl)acetamidine 175-211 interferon gamma Homo sapiens 146-155 23973311-7 2014 ZNS inhibited IFNgamma-induced elevation of KYN, KYNA and QUNA, but enhanced IFNgamma-induced that of CNBA. Zonisamide 0-3 interferon gamma Homo sapiens 14-22 23973311-7 2014 ZNS inhibited IFNgamma-induced elevation of KYN, KYNA and QUNA, but enhanced IFNgamma-induced that of CNBA. Zonisamide 0-3 interferon gamma Homo sapiens 77-85 25189392-0 2014 Dual effect of interferon (IFNgamma)-induced nitric oxide on tumorigenesis and intracellular bacteria. Nitric Oxide 45-57 interferon gamma Homo sapiens 27-35 23512754-7 2014 Besides, CDM not only synergized TNF-alpha production combined with IFN-gamma, but also prolonged its expression in time. 1-cinnamoyl-3,11-dihydroxymeliacarpin 9-12 interferon gamma Homo sapiens 68-77 24106983-8 2014 A robust mitogen-induced IFN-gamma response was seen in samples from 14 patients (88%) despite therapy with high-dose corticosteroids, cyclophosphamide, fludarabine, gemtuzumab ozogamicin, and alemtuzumab. Cyclophosphamide 135-151 interferon gamma Homo sapiens 25-34 24520787-9 2014 ELISA results showed that the peripheral serum level of IFN-gamma was significantly higher in the BHS group than in the BSS group and the healthy control group (P < 0.05). bss 120-123 interferon gamma Homo sapiens 56-65 24376420-3 2013 The pro-inflammatory cytokine interferon-gamma (IFN-gamma) and related biochemical pathways like tryptophan breakdown by indoleamine 2,3-dioxygenase (IDO) and neopterin formation are deeply involved in their pathogenesis. Tryptophan 97-107 interferon gamma Homo sapiens 30-46 24611083-6 2014 The frequency of IFN-gamma+/tumor necrosis factor-alpha (TNF-alpha)+CD45RO+CD4+ T-cells upon stimulation with phorbol myristate acetate (PMA)/Ionomycin was higher in 2-3 months old infants who received BCG vaccination at birth compared to those who did not. Tetradecanoylphorbol Acetate 110-135 interferon gamma Homo sapiens 17-26 24611083-6 2014 The frequency of IFN-gamma+/tumor necrosis factor-alpha (TNF-alpha)+CD45RO+CD4+ T-cells upon stimulation with phorbol myristate acetate (PMA)/Ionomycin was higher in 2-3 months old infants who received BCG vaccination at birth compared to those who did not. Tetradecanoylphorbol Acetate 137-140 interferon gamma Homo sapiens 17-26 24611083-6 2014 The frequency of IFN-gamma+/tumor necrosis factor-alpha (TNF-alpha)+CD45RO+CD4+ T-cells upon stimulation with phorbol myristate acetate (PMA)/Ionomycin was higher in 2-3 months old infants who received BCG vaccination at birth compared to those who did not. Ionomycin 142-151 interferon gamma Homo sapiens 17-26 23993587-0 2013 Modulation of interferon-gamma synthesis by the effects of lignin-like enzymatically polymerized polyphenols on antigen-presenting cell activation and the subsequent cell-to-cell interactions. Lignin 59-65 interferon gamma Homo sapiens 14-30 23993587-0 2013 Modulation of interferon-gamma synthesis by the effects of lignin-like enzymatically polymerized polyphenols on antigen-presenting cell activation and the subsequent cell-to-cell interactions. Polyphenols 97-108 interferon gamma Homo sapiens 14-30 23993587-7 2013 Additionally, adequate interferon-gamma (IFN-gamma) induction by polymerized polyphenols was mediated by the coexistence of APCs and T cells because the addition of T cells to PCCs increased IFN-gamma production. Polyphenols 77-88 interferon gamma Homo sapiens 23-39 23993587-7 2013 Additionally, adequate interferon-gamma (IFN-gamma) induction by polymerized polyphenols was mediated by the coexistence of APCs and T cells because the addition of T cells to PCCs increased IFN-gamma production. Polyphenols 77-88 interferon gamma Homo sapiens 41-50 23993587-7 2013 Additionally, adequate interferon-gamma (IFN-gamma) induction by polymerized polyphenols was mediated by the coexistence of APCs and T cells because the addition of T cells to PCCs increased IFN-gamma production. Polyphenols 77-88 interferon gamma Homo sapiens 191-200 24157376-4 2013 MATERIALS AND METHODS: The effects of three concentrations of the extract, dexamethasone, and saline on interleukin 4 (IL-4) and interferon gamma (IFN-gamma) gene expression were evaluated in phytohemagglutinin (PHA) stimulated and non-stimulated human peripheral blood mononuclear cells (hPBMCs). Sodium Chloride 94-100 interferon gamma Homo sapiens 129-156 24349194-8 2013 Moreover, adipocyte incubation with BPA was accompanied by increased release of IL-6 and IFN-gamma, as assessed by multiplex ELISA assays, and by activation of JNK, STAT3 and NFkB pathways. bisphenol A 36-39 interferon gamma Homo sapiens 89-98 24376420-3 2013 The pro-inflammatory cytokine interferon-gamma (IFN-gamma) and related biochemical pathways like tryptophan breakdown by indoleamine 2,3-dioxygenase (IDO) and neopterin formation are deeply involved in their pathogenesis. Tryptophan 97-107 interferon gamma Homo sapiens 48-57 24376420-3 2013 The pro-inflammatory cytokine interferon-gamma (IFN-gamma) and related biochemical pathways like tryptophan breakdown by indoleamine 2,3-dioxygenase (IDO) and neopterin formation are deeply involved in their pathogenesis. Neopterin 159-168 interferon gamma Homo sapiens 30-46 24376420-3 2013 The pro-inflammatory cytokine interferon-gamma (IFN-gamma) and related biochemical pathways like tryptophan breakdown by indoleamine 2,3-dioxygenase (IDO) and neopterin formation are deeply involved in their pathogenesis. Neopterin 159-168 interferon gamma Homo sapiens 48-57 24348476-12 2013 Such iPS-derived NKT cells produce IFN-gamma in vitro and in vivo upon stimulation with alpha-GalCer/DCs, and mediated adjuvant effects, suppressing tumor growth in vivo. IPS 5-8 interferon gamma Homo sapiens 35-44 23879671-11 2013 CONCLUSIONS: Azithromycin treatment decreased the mucocutaneous manifestations in BD patients and suppressed the intracellular IFN-gamma responses of PBMCs to S. sanguinis ex vivo, which suggests this treatment has an immunomodulatory effect. Azithromycin 13-25 interferon gamma Homo sapiens 127-136 24291824-6 2013 Interestingly, ER stress inhibited PGE2 + IFNgamma-induced iNOS expression. Dinoprostone 35-39 interferon gamma Homo sapiens 42-50 24043258-4 2013 In the absence of glucose, IFN-gamma-induced phosphorylation of JAK and STAT proteins and human leukocyte antigen (HLA)-DR expression were lower in 3D-EC compared with TC-EC. tc-ec 168-173 interferon gamma Homo sapiens 27-36 24043258-7 2013 Glucose significantly augmented IFN-gamma-dependent signaling pathways in TC-EC. Glucose 0-7 interferon gamma Homo sapiens 32-41 24043258-7 2013 Glucose significantly augmented IFN-gamma-dependent signaling pathways in TC-EC. tc-ec 74-79 interferon gamma Homo sapiens 32-41 24043258-8 2013 IFN-gamma-induced phosphorylation of JAK and STAT proteins as well as HLA-DR expression by ECs in low- and high-glucose medium was significantly lower in 3-D than in two-dimensional environment. Glucose 112-119 interferon gamma Homo sapiens 0-9 24043258-10 2013 In conclusion, low- and high-glucose concentrations amplify IFN-gamma-induced signaling pathways in TC-EC. Glucose 29-36 interferon gamma Homo sapiens 60-69 24043258-10 2013 In conclusion, low- and high-glucose concentrations amplify IFN-gamma-induced signaling pathways in TC-EC. tc-ec 100-105 interferon gamma Homo sapiens 60-69 23968562-4 2013 Rapamycin inhibited the ability of both TLR-7-activated and TLR-9-activated PDC to stimulate production of IFN-gamma and interleukin (IL)-10 by allogeneic T cells. Sirolimus 0-9 interferon gamma Homo sapiens 107-116 23789621-6 2013 However, while HDM-elicited TNF-alpha (tumour necrosis factor-alpha), IFN-gamma (interferon-gamma), IL (interleukin)-2, IL-5 and IL-10 were sensitive to prednisolone treatment, concomitant infection with RSV blocked the sensitivity towards steroid. Prednisolone 153-165 interferon gamma Homo sapiens 70-79 23796976-4 2013 Total bilirubin (TB) was measured and the association between TB and IFN-gamma, sICAM-1, interleukin-17 were analyzed. Bilirubin 62-64 interferon gamma Homo sapiens 69-78 23796976-9 2013 TB levels were positively correlated with IFN-gamma, interleukin-17 and sICAM-1 levels. Bilirubin 0-2 interferon gamma Homo sapiens 42-51 23912646-4 2013 In this study, the release of interleukin-2 (IL-2), interleukin-4 (IL-4), and interferon-gamma (IFN-gamma) by CD4+ T lymphocytes prior to aspirin desensitization were also measured at intracellular levels, and expression of these cytokines after 1 month aspirin desensitization was evaluated. Aspirin 138-145 interferon gamma Homo sapiens 96-105 23912646-4 2013 In this study, the release of interleukin-2 (IL-2), interleukin-4 (IL-4), and interferon-gamma (IFN-gamma) by CD4+ T lymphocytes prior to aspirin desensitization were also measured at intracellular levels, and expression of these cytokines after 1 month aspirin desensitization was evaluated. Aspirin 254-261 interferon gamma Homo sapiens 96-105 23933845-3 2013 The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-gamma and TNF-alpha-NHEK activated cells. Peptide T 52-54 interferon gamma Homo sapiens 182-191 23933845-3 2013 The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-gamma and TNF-alpha-NHEK activated cells. dhurrin 96-103 interferon gamma Homo sapiens 182-191 23933845-3 2013 The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-gamma and TNF-alpha-NHEK activated cells. prunasin 108-116 interferon gamma Homo sapiens 182-191 24100191-0 2013 Pretreatment of aripiprazole and minocycline, but not haloperidol, suppresses oligodendrocyte damage from interferon-gamma-stimulated microglia in co-culture model. Aripiprazole 16-28 interferon gamma Homo sapiens 106-122 24080250-9 2013 Montelukast significantly suppressed the release of IL-8 (p = 0.016), IL-6 (p = 0.006), RANTES (p = 0.002) and IFN-gamma (p = 0.046), in a dose dependent manner in unstimulated cultures but not in those stimulated with IL-1/TNF. montelukast 0-11 interferon gamma Homo sapiens 111-120 24100191-0 2013 Pretreatment of aripiprazole and minocycline, but not haloperidol, suppresses oligodendrocyte damage from interferon-gamma-stimulated microglia in co-culture model. Minocycline 33-44 interferon gamma Homo sapiens 106-122 24100191-6 2013 Pretreatment of aripiprazole and minocycline suppressed apoptosis of oligodendrocytes in the co-culture model with interferon-gamma (IFN-gamma)-activated microglia, while haloperidol, a traditional antipsychotic drug, did not. Aripiprazole 16-28 interferon gamma Homo sapiens 115-131 24100191-6 2013 Pretreatment of aripiprazole and minocycline suppressed apoptosis of oligodendrocytes in the co-culture model with interferon-gamma (IFN-gamma)-activated microglia, while haloperidol, a traditional antipsychotic drug, did not. Aripiprazole 16-28 interferon gamma Homo sapiens 133-142 24100191-6 2013 Pretreatment of aripiprazole and minocycline suppressed apoptosis of oligodendrocytes in the co-culture model with interferon-gamma (IFN-gamma)-activated microglia, while haloperidol, a traditional antipsychotic drug, did not. Minocycline 33-44 interferon gamma Homo sapiens 115-131 24100191-6 2013 Pretreatment of aripiprazole and minocycline suppressed apoptosis of oligodendrocytes in the co-culture model with interferon-gamma (IFN-gamma)-activated microglia, while haloperidol, a traditional antipsychotic drug, did not. Minocycline 33-44 interferon gamma Homo sapiens 133-142 24100191-7 2013 Aripiprazole and minocycline inhibited the production of tumor necrosis factor-alpha (TNF-alpha) from IFN-gamma-activated microglia. Aripiprazole 0-12 interferon gamma Homo sapiens 102-111 24100191-7 2013 Aripiprazole and minocycline inhibited the production of tumor necrosis factor-alpha (TNF-alpha) from IFN-gamma-activated microglia. Minocycline 17-28 interferon gamma Homo sapiens 102-111 24177007-0 2013 ER stress-mediated regulation of immune function under glucose-deprived condition in glial cells: up- and down-regulation of PGE2 + IFNgamma-induced IL-6 and iNOS expressions. Glucose 55-62 interferon gamma Homo sapiens 132-140 23882022-2 2013 The antiviral tryptophan-catabolising enzyme indoleamine 2,3-dioxygenase (IDO) is induced by interferon-gamma and suppressed by Th2 mediators interleukin (IL)-4 and IL-13. Tryptophan 14-24 interferon gamma Homo sapiens 93-109 24177007-4 2013 On the other hand, to our surprise, we found that PGE2+IFNgamma-induced iNOS expression was attenuated under glucose-deprived condition. Dinoprostone 50-54 interferon gamma Homo sapiens 55-63 24177007-4 2013 On the other hand, to our surprise, we found that PGE2+IFNgamma-induced iNOS expression was attenuated under glucose-deprived condition. Glucose 109-116 interferon gamma Homo sapiens 55-63 24240045-0 2013 Endogenous IFNgamma in chronic HCV genotype 4 patients treated with PEG-IFNalpha and ribavirin. Ribavirin 85-94 interferon gamma Homo sapiens 11-19 24240045-4 2013 The role of endogenous interferon gamma (IFNgamma) in Egyptian patients infected with chronic HCV and treated with PEG-IFN/ribavirin is uncertain. Ribavirin 123-132 interferon gamma Homo sapiens 23-50 23795941-7 2013 Prestimulation of hUTC or human MSC with interferon gamma (IFN-gamma) induced expression of the tryptophan degrading enzyme indoleamine 2, 3 dioxygenase, facilitating enhanced suppression. Tryptophan 96-106 interferon gamma Homo sapiens 41-68 24240045-5 2013 The goal of this study was to evaluate the association of IFNgamma and chronic HCV infection among patients treated with combination therapy of PEG-IFN/ribavirin. peg-ifn 144-151 interferon gamma Homo sapiens 58-66 24240045-5 2013 The goal of this study was to evaluate the association of IFNgamma and chronic HCV infection among patients treated with combination therapy of PEG-IFN/ribavirin. Ribavirin 152-161 interferon gamma Homo sapiens 58-66 23900211-7 2013 Moreover, DZNep treatment resulted in a significant decrease of interferon-gamma, tumor necrosis factor-alpha, granzyme B, TRAIL, and Fas ligand expressing donor-derived CD8 T cells, suggesting a multilevel modulation role on T-cell survival and effect in vivo. 3-deazaneplanocin 10-15 interferon gamma Homo sapiens 64-109 24206576-9 2013 In the cured individuals who responded to SLA, effector memory (CD45RA-CCR7-) CD4+ T cells were the ones producing IFN-gamma. (S)-lipoic acid 42-45 interferon gamma Homo sapiens 115-124 24232460-5 2013 Sunitinib promoted Th1-inducing and pro-inflammatory phenotypes (IL-12, IFN-gamma and IL-6) in DCs at the expense of Th2 inducing phenotype (IL-13) and regulatory phenotype (PD-L1, IDO). Sunitinib 0-9 interferon gamma Homo sapiens 72-81 24232460-6 2013 Sunitinib-treated DCs subsequently induced the upregulation of Th1 phenotypic markers (IFN-gamma and T-bet) and the downregulation of the Th2 signature (GATA-3) and the Th17 marker (RORC) on the CD3+CD56+ subset of CIK cells. Sunitinib 0-9 interferon gamma Homo sapiens 87-96 24022492-5 2013 The aim of this study was to investigate whether activation of TCPTP by spermidine was capable of alleviating IFN-gamma-induced, proinflammatory signaling and barrier dysfunction in human intestinal epithelial cells. Spermidine 72-82 interferon gamma Homo sapiens 110-119 24244339-14 2013 The vaccine induced both antibody titers and CD8 T cells producing IFNgamma and TNFalpha with specificity to CS while eliciting modest neutralizing antibody responses against Ad35. Cesium 109-111 interferon gamma Homo sapiens 67-75 24022492-6 2013 Studies revealed that treatment of T84 and HT29/cl.19A colonocytes with spermidine increased both TCPTP protein levels and enzymatic activity, correlating with a decrease in the phosphorylation of the signal transducers and activators of transcription 1 and 3, downstream mediators of IFN-gamma signaling, upon coadministration of spermidine to IFN-gamma-treated cells. Spermidine 72-82 interferon gamma Homo sapiens 285-294 24022492-6 2013 Studies revealed that treatment of T84 and HT29/cl.19A colonocytes with spermidine increased both TCPTP protein levels and enzymatic activity, correlating with a decrease in the phosphorylation of the signal transducers and activators of transcription 1 and 3, downstream mediators of IFN-gamma signaling, upon coadministration of spermidine to IFN-gamma-treated cells. Spermidine 72-82 interferon gamma Homo sapiens 345-354 23909256-7 2013 The IFN-gamma response following isoniazid therapy declined and became QFT-GIT negative in 8% of 26 patients with LTBI; in 69% of subjects with LTBI the QFT-GIT remained persistently positive with a significant increase of IFN-gamma levels during the follow-up, even if no cases of active tuberculosis were found. Isoniazid 33-42 interferon gamma Homo sapiens 4-13 24022492-7 2013 On a functional level, spermidine protected barrier function in the setting of inflammation, restricting the decrease in transepithelial electrical resistance and the increase in epithelial permeability induced by IFN-gamma in coincubation experiments. Spermidine 23-33 interferon gamma Homo sapiens 214-223 24022492-8 2013 These data implicate spermidine as a potential therapeutic agent to treat conditions associated with elevated IFN-gamma signaling and a faulty mucosal barrier. Spermidine 21-31 interferon gamma Homo sapiens 110-119 23909256-7 2013 The IFN-gamma response following isoniazid therapy declined and became QFT-GIT negative in 8% of 26 patients with LTBI; in 69% of subjects with LTBI the QFT-GIT remained persistently positive with a significant increase of IFN-gamma levels during the follow-up, even if no cases of active tuberculosis were found. Isoniazid 33-42 interferon gamma Homo sapiens 223-232 23800176-5 2013 Results showed that IFN-gamma and high glucose synergistically stimulated matrix metalloproteinase 1 (MMP-1), a proteinase essential for vascular tissue remodelling and atherosclerosis, in U937 mononuclear cells, but Rs-LPS inhibited the MMP-1 stimulation. rs-lps 217-223 interferon gamma Homo sapiens 20-29 24055018-2 2013 The pro-inflammatory cytokine interferon-gamma in various cells, including monocytes, induces neopterin production. Neopterin 94-103 interferon gamma Homo sapiens 30-46 23956301-6 2013 The results of a (51)Cr release assay demonstrated that IFN-gamma-treated KCs-E7 escaped from CTL recognition because HPV16 E7 downregulated MHC class I antigen presentation on KCs. Chromium 21-23 interferon gamma Homo sapiens 56-65 24103581-6 2013 Up-regulation of intracellular perforin, granzyme B expression and IFN-gamma production may be the important mechanism of dihydroartemisinin on increased antitumor activity of gammadelta T cells. artenimol 122-140 interferon gamma Homo sapiens 67-76 24021943-7 2013 Treatment with anti-CD137 blocking with prednisolone further reduced IFN-gamma, TNF-alpha, and granzyme B in these cells. Prednisolone 40-52 interferon gamma Homo sapiens 69-78 23954282-0 2013 Toll like receptor 2 agonists lipoteichoic acid and peptidoglycan are able to enhance antigen specific IFNgamma release in whole blood during recall antigen responses. lipoteichoic acid 30-47 interferon gamma Homo sapiens 103-111 23685139-0 2013 Clinical drug response to thiopurines is associated to a lower interferon-gamma production by IBD patient"s T lymphocytes. thiopurines 26-37 interferon gamma Homo sapiens 63-79 24482747-4 2013 In particular, lenalidomide has been shown to stimulate the cytotoxic functions of T lymphocytes and natural killer cells, to limit the immunosuppressive impact of regulatory T cells, and to modulate the secretion of a wide range of cytokines, including tumor necrosis factor alpha, interferon gamma as well as interleukin (IL)-6, IL-10, and IL-12. Lenalidomide 15-27 interferon gamma Homo sapiens 283-299 23721189-0 2013 Increase of interferon-gamma inducible CXCL9 and CXCL11 serum levels in patients with active Graves" disease and modulation by methimazole therapy. Methimazole 127-138 interferon gamma Homo sapiens 12-28 23954282-9 2013 TLR3 agonist Poly(I:C) and TLR5 agonist Fla also induced a twofold increase in IFNgamma synthesis (2.230 vs. 1.085 pg/ml for Poly(I:C) and 518 vs. 278 pg/ml for Fla, respectively), but background expression was slightly increased (114 vs. 7 pg/ml for Poly(I:C) and 47 vs. 12 pg/ml for Fla, respectively). poly 13-17 interferon gamma Homo sapiens 79-87 24284004-4 2013 The purpose of this project was to investigate the in vitro influence of RU534 on IFN-gamma and IL-4 synthesis by peripheral blood T cells isolated from healthy bitches (N = 16) in luteal phase. ru534 73-78 interferon gamma Homo sapiens 82-91 24284004-8 2013 Moreover, mitogen-activated PBMCs treated with RU534 displayed similar concentration of IFN-gamma and IL-4 in culture supernatants to those observed in mitogen-activated DMSO-treated PBMCs. ru534 47-52 interferon gamma Homo sapiens 88-97 24348641-10 2013 CONCLUSIONS: Results showed that HCVcp + BCG induced a moderate CTL and mixed Th1/Th2 immune responses with higher levels of cell proliferation and IFN-gamma secretion, indicating that BCG may have a better outcome when formulated in HCVcp-based subunit vaccines. hcvcp 33-38 interferon gamma Homo sapiens 148-157 24204766-9 2013 Compared to the controls, the NK cells of CRS group had an impaired ability to degranulate and to produce cytokines such as IFN-gamma and TNF-alpha. 3-cresol 42-45 interferon gamma Homo sapiens 124-133 23872327-12 2013 In addition, IVE and its constituents (p-anisaldehyde and trans-anethole) effectively suppressed IFN-gamma-induced adherence of Jurkat T cells to HaCaT cells and ICAM-1 expression on the cell surface. 4-anisaldehyde 39-53 interferon gamma Homo sapiens 97-106 24179731-4 2013 Patients with IIH had highly elevated IL-2, IL-4, IL-10, IL-17 and IFNgamma in the CSF compared to patients with multiple sclerosis or non-organic/non-inflammatory neurological conditions. 4-(7-Chloro-1,3-Benzoxazol-2-Yl)-2,6-Diiodophenol 14-17 interferon gamma Homo sapiens 67-75 23830817-7 2013 The results showed that both 1-ribofuranosyl-s-triazin-2(1H)-one and pistillarin exhibited significant immunosuppressive effects on phytohemagglutinin (PHA)-stimulated human PBMCs by inhibiting [methyl-(3)H]-thymidine uptake and inflammatory cytokines productions such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, interferon (IFN)-gamma and IL-1beta. 1-ribofuranosyl-s-triazin-2(1H)-one 29-64 interferon gamma Homo sapiens 328-350 23830817-7 2013 The results showed that both 1-ribofuranosyl-s-triazin-2(1H)-one and pistillarin exhibited significant immunosuppressive effects on phytohemagglutinin (PHA)-stimulated human PBMCs by inhibiting [methyl-(3)H]-thymidine uptake and inflammatory cytokines productions such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, interferon (IFN)-gamma and IL-1beta. pistillarin 69-80 interferon gamma Homo sapiens 328-350 23872327-12 2013 In addition, IVE and its constituents (p-anisaldehyde and trans-anethole) effectively suppressed IFN-gamma-induced adherence of Jurkat T cells to HaCaT cells and ICAM-1 expression on the cell surface. anethole 58-72 interferon gamma Homo sapiens 97-106 24174363-4 2013 According to our GSEA approach on the microarray datasets related to AS, we have identified the significantly associated pathways with this disease respectively dependent and independent to the factor of interferon-gamma (IFN-gamma). gsea 17-21 interferon gamma Homo sapiens 204-220 23942267-0 2013 Sodium butyrate inhibits interferon-gamma induced indoleamine 2,3-dioxygenase expression via STAT1 in nasopharyngeal carcinoma cells. Butyric Acid 0-15 interferon gamma Homo sapiens 25-41 23942267-4 2013 Our previous studies revealed that NaB could inhibit IFN-gamma induced IDO expression in nasopharyngeal carcinoma cells, CNE2. nab 35-38 interferon gamma Homo sapiens 53-62 23942267-5 2013 In the present study, we aim to investigate to the mechanism of NaB interfering with the interferon-gamma (IFN-gamma)-mediated IDO expression signaling transduction. nab 64-67 interferon gamma Homo sapiens 89-105 23942267-5 2013 In the present study, we aim to investigate to the mechanism of NaB interfering with the interferon-gamma (IFN-gamma)-mediated IDO expression signaling transduction. nab 64-67 interferon gamma Homo sapiens 107-116 23942267-8 2013 KEY FINDINGS: We found that NaB inhibited IFN-gamma-induced IDO expression in CNE2 cells via decreasing phosphorylation and nuclear translocation of STAT1, but not via down-regulation of IFN-gamma-receptor (IFNGR). nab 28-31 interferon gamma Homo sapiens 42-51 23942267-11 2013 SIGNIFICANCE: These results suggest that NaB inhibited IFN-gamma-induced IDO expression via STAT1 increased acetylation, decreased phosphorylation, and reduced nuclear translocation. nab 41-44 interferon gamma Homo sapiens 55-64 24174363-4 2013 According to our GSEA approach on the microarray datasets related to AS, we have identified the significantly associated pathways with this disease respectively dependent and independent to the factor of interferon-gamma (IFN-gamma). gsea 17-21 interferon gamma Homo sapiens 222-231 24174363-6 2013 On the contrary, 11 most significantly up-regulated pathways such as renin-angiotensin system, O-Glycan biosynthesis and gap junction in the comparison of AS patients to control under the treatment of IFN in IFN-gamma-dependent study. o-glycan 95-103 interferon gamma Homo sapiens 208-217 23879623-5 2013 We observed a great variability in the levels of IDO1 mRNA expression and kynurenine release between skin cells and melanoma cell lines in response to interferon-gamma, a classical IDO1 inducer. Kynurenine 74-84 interferon gamma Homo sapiens 151-167 23962407-4 2013 Transcriptional network analysis showed IFN-gamma as an important regulatory node, with pioglitazone treatment inducing transcriptional repression of various genes implicated in T cell responses. Pioglitazone 88-100 interferon gamma Homo sapiens 40-49 23881028-12 2013 RT variants generating high total ROS levels induced significantly stronger IFN-gamma responses than the variants inducing lower total ROS, while high levels of ROS normalized per unit of protein in expressing cell were associated with a weak IFN-gamma response. Reactive Oxygen Species 34-37 interferon gamma Homo sapiens 76-85 23421558-12 2013 In all patients, the interferon-gamma response of T lymphocytes to phorbolmyristate acetate-ionomycin was higher compared with normal donors, but it was further increased after tumor ablation only in prostate cancer patients. Tetradecanoylphorbol Acetate 67-91 interferon gamma Homo sapiens 21-37 24151804-5 2013 Cytokines such as IL-1ss, TNF-alpha and IFN-gamma seem to contribute to the pathophysiology of depression by activating monoamine reuptake, stimulating the hypothalamic-pituitary-adrenocortical (HPA) axis and decreasing production of serotonin due to increased activity of indolamine-2,3-dioxygenase (IDO). monoamine 120-129 interferon gamma Homo sapiens 40-49 23806637-0 2013 Prominent role of IFN-gamma in patients with aspirin-exacerbated respiratory disease. Aspirin 45-52 interferon gamma Homo sapiens 18-27 23806637-5 2013 RESULTS: Gene expression analysis revealed that tissue from both aspirin-tolerant subjects and patients with AERD display a TH2 cytokine signature; however, AERD was distinguished from chronic hyperplastic eosinophilic sinusitis by the prominent expression of IFN-gamma. Aspirin 65-72 interferon gamma Homo sapiens 260-269 23806637-8 2013 Additionally, IFN-gamma increased the expression of genes involved in leukotriene synthesis that led to increased secretion of CysLTs. Leukotrienes 70-81 interferon gamma Homo sapiens 14-23 23806637-10 2013 CONCLUSIONS: High IFN-gamma levels distinguish AERD from aspirin-tolerant asthma and underlie the robust constitutive and aspirin-induced secretion of CysLTs that characterize this disorder. Aspirin 57-64 interferon gamma Homo sapiens 18-27 23806637-10 2013 CONCLUSIONS: High IFN-gamma levels distinguish AERD from aspirin-tolerant asthma and underlie the robust constitutive and aspirin-induced secretion of CysLTs that characterize this disorder. Aspirin 122-129 interferon gamma Homo sapiens 18-27 23421558-12 2013 In all patients, the interferon-gamma response of T lymphocytes to phorbolmyristate acetate-ionomycin was higher compared with normal donors, but it was further increased after tumor ablation only in prostate cancer patients. Ionomycin 92-101 interferon gamma Homo sapiens 21-37 23975864-11 2013 The IFN-gamma-mediated induction of Trim21 was completely abolished by inhibiting protein synthesis with cycloheximide, and Trim21 expression could not be induced by IFN-gamma in Irf1(-/-) cells, demonstrating that IFN-gamma induces Trim21 indirectly via IRF1 and not directly via STAT1 activation. Cycloheximide 105-118 interferon gamma Homo sapiens 4-13 23747755-0 2013 IFN-gamma inhibits liver progenitor cell proliferation in HBV-infected patients and in 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-fed mice. 3,5-diethoxycarbonyl-1,4-dihydrocollidine 87-128 interferon gamma Homo sapiens 0-9 23811143-9 2013 Levels of IFN-gamma, IgG and IgA were all inversely associated with whole blood chromium, while C3 and C4 were positively associated with whole blood chromium (p<0.05). Chromium 80-88 interferon gamma Homo sapiens 10-19 23918204-6 2013 Although IFN-gamma alone had no effect, it potentiated IL-1beta-induced ROS production in a time-dependent manner. Reactive Oxygen Species 72-75 interferon gamma Homo sapiens 9-18 23918204-9 2013 Glutamate uptake, which represents one of the most important methods of astrocytes to prevent excitotoxicity, was down-regulated in IL-1beta-activated astrocytes, and was further suppressed in the presence of IFN-gamma; IFN-gamma itself exerted minimal effect. Glutamic Acid 0-9 interferon gamma Homo sapiens 209-218 23918204-9 2013 Glutamate uptake, which represents one of the most important methods of astrocytes to prevent excitotoxicity, was down-regulated in IL-1beta-activated astrocytes, and was further suppressed in the presence of IFN-gamma; IFN-gamma itself exerted minimal effect. Glutamic Acid 0-9 interferon gamma Homo sapiens 220-229 23918204-10 2013 Elevated levels of 8-isoprostane in IL-1beta +- IFN-gamma-activated human astrocytes indicate downstream lipid peroxidation. 8-epi-prostaglandin F2alpha 19-32 interferon gamma Homo sapiens 48-57 23918204-11 2013 Pretreatment with diphenyleneiodonium abolished the IL-1beta +- IFN-gamma-induced ROS production, restored glutamate uptake function and reduced 8-isoprostane to near control levels suggesting that ROS contributes to the dysfunction of activated astrocytes. diphenyleneiodonium 18-37 interferon gamma Homo sapiens 64-73 23918204-11 2013 Pretreatment with diphenyleneiodonium abolished the IL-1beta +- IFN-gamma-induced ROS production, restored glutamate uptake function and reduced 8-isoprostane to near control levels suggesting that ROS contributes to the dysfunction of activated astrocytes. Reactive Oxygen Species 82-85 interferon gamma Homo sapiens 64-73 23918204-11 2013 Pretreatment with diphenyleneiodonium abolished the IL-1beta +- IFN-gamma-induced ROS production, restored glutamate uptake function and reduced 8-isoprostane to near control levels suggesting that ROS contributes to the dysfunction of activated astrocytes. Glutamic Acid 107-116 interferon gamma Homo sapiens 64-73 23918204-11 2013 Pretreatment with diphenyleneiodonium abolished the IL-1beta +- IFN-gamma-induced ROS production, restored glutamate uptake function and reduced 8-isoprostane to near control levels suggesting that ROS contributes to the dysfunction of activated astrocytes. 8-epi-prostaglandin F2alpha 145-158 interferon gamma Homo sapiens 64-73 23918204-11 2013 Pretreatment with diphenyleneiodonium abolished the IL-1beta +- IFN-gamma-induced ROS production, restored glutamate uptake function and reduced 8-isoprostane to near control levels suggesting that ROS contributes to the dysfunction of activated astrocytes. Reactive Oxygen Species 198-201 interferon gamma Homo sapiens 64-73 24348286-12 2013 IL-10/IFN-gamma ratio was significantly lower in Group II in samples C and D. CONCLUSION: Replacing GA with PVB can attenuate cytokines response to cancer breast surgeries. pvb 108-111 interferon gamma Homo sapiens 6-15 23336953-2 2013 Neopterin production and tryptophan catabolism through the kynurenine pathway, measured by the kynurenine-tryptophan ratio (KTR), are induced by interferon gamma, thus both are considered markers of cell mediated immune activation. Neopterin 0-9 interferon gamma Homo sapiens 145-161 23336953-2 2013 Neopterin production and tryptophan catabolism through the kynurenine pathway, measured by the kynurenine-tryptophan ratio (KTR), are induced by interferon gamma, thus both are considered markers of cell mediated immune activation. kynurenine-tryptophan 95-116 interferon gamma Homo sapiens 145-161 23336953-2 2013 Neopterin production and tryptophan catabolism through the kynurenine pathway, measured by the kynurenine-tryptophan ratio (KTR), are induced by interferon gamma, thus both are considered markers of cell mediated immune activation. Tryptophan 25-35 interferon gamma Homo sapiens 145-161 23336953-2 2013 Neopterin production and tryptophan catabolism through the kynurenine pathway, measured by the kynurenine-tryptophan ratio (KTR), are induced by interferon gamma, thus both are considered markers of cell mediated immune activation. Kynurenine 59-69 interferon gamma Homo sapiens 145-161 23701916-0 2013 Increased production of IFN-gamma by natural killer cells triggered with bone marrow-derived dendritic cells cultured in the presence of retinoic acid. Tretinoin 137-150 interferon gamma Homo sapiens 24-33 24040033-11 2013 CONCLUSIONS: Activation of PTPN2 by spermidine ameliorates IFN-gamma-induced inflammatory responses in THP-1 cells. Spermidine 36-46 interferon gamma Homo sapiens 59-68 23600999-6 2013 CONCLUSIONS: These data suggest that defects in viral-induced IFN-gamma from CD8+ T cells contribute to the ADEH+ phenotype. adeh 108-112 interferon gamma Homo sapiens 62-71 24008730-7 2013 SAA-treated BMDC that were serum starved for 48 h remained capable of presenting antigen and induced OTII CD4(+) T cells to secrete IL-17A, IL-17F, IL-21, IL-22, and IFNgamma in the presence of ovalbumin. bmdc 12-16 interferon gamma Homo sapiens 166-174 24008730-8 2013 IL-17A, IL-17F, IL-21, and IFNgamma production occurred even when the CD4(+) T cells were treated with dexamethasone (Dex), whereas glucocorticoid treatment abolished cytokine secretion by T cells cocultured with untreated serum-starved BMDC. Dexamethasone 103-116 interferon gamma Homo sapiens 27-35 24034707-8 2013 Thus, lack of inhibitory NK cell function during allo-specific T cell activation by human ICC + IFN-gamma-stimulated RAPA-DC may represent an unwanted effector mechanism that may underlie RAPA-induced inflammatory events in transplant patients undergoing microbial infection or allograft rejection. Sirolimus 117-121 interferon gamma Homo sapiens 96-105 23589093-8 2013 Our results demonstrated that lidocaine dose-dependently inhibited the proliferative response and the release of IL-4, IL-5, IL-13, TNF-alpha, and IFN-gamma from SEA- and SEB-stimulated PBMCs and also blocked the down-regulation of FLG expression in HaCaT cells co-cultured with SEA- and SEB-activated PBMCs. Lidocaine 30-39 interferon gamma Homo sapiens 147-156 26785981-5 2013 ESAT6-induced IFN-gamma responses were positive in 32% of TB cases as compared with 15% of EC cases (p=0.048). Terbium 58-60 interferon gamma Homo sapiens 14-23 24084352-3 2013 In the former, interferon-gamma induces both neopterin release and the enzyme indoleamine [2, 3]-dioxygenase (IDO) in various cells. Neopterin 45-54 interferon gamma Homo sapiens 15-31 23867329-4 2013 Among 392 patients, active PTB patients had stronger IFN-gamma responses to TB antigen (TBAg-Nil, P < 0.001) and lower responses to mitogen (Mitogen-Nil, P < 0.001). tbag 88-92 interferon gamma Homo sapiens 53-62 26785981-8 2013 Measurement of IFN-gamma or CXCL9 together diagnosed TB (53%) cases and was significant as compared with EC (p=0.014) cases. Terbium 53-55 interferon gamma Homo sapiens 15-24 26785981-10 2013 Within TB groups, ESAT6-IFN-gamma/CXCL9-based detection increased to 53% in PTB (p=0.031) and 54% in ETB (p=0.021), with comparable diagnosis in less severe extrapulmonary TB (L-ETB, 55%) and severe disseminated extrapulmonary TB (D-ETB, 50%). Terbium 7-9 interferon gamma Homo sapiens 24-33 26785981-10 2013 Within TB groups, ESAT6-IFN-gamma/CXCL9-based detection increased to 53% in PTB (p=0.031) and 54% in ETB (p=0.021), with comparable diagnosis in less severe extrapulmonary TB (L-ETB, 55%) and severe disseminated extrapulmonary TB (D-ETB, 50%). etb 101-104 interferon gamma Homo sapiens 24-33 26785981-10 2013 Within TB groups, ESAT6-IFN-gamma/CXCL9-based detection increased to 53% in PTB (p=0.031) and 54% in ETB (p=0.021), with comparable diagnosis in less severe extrapulmonary TB (L-ETB, 55%) and severe disseminated extrapulmonary TB (D-ETB, 50%). Terbium 77-79 interferon gamma Homo sapiens 24-33 26785981-10 2013 Within TB groups, ESAT6-IFN-gamma/CXCL9-based detection increased to 53% in PTB (p=0.031) and 54% in ETB (p=0.021), with comparable diagnosis in less severe extrapulmonary TB (L-ETB, 55%) and severe disseminated extrapulmonary TB (D-ETB, 50%). l-etb 176-181 interferon gamma Homo sapiens 24-33 26785981-10 2013 Within TB groups, ESAT6-IFN-gamma/CXCL9-based detection increased to 53% in PTB (p=0.031) and 54% in ETB (p=0.021), with comparable diagnosis in less severe extrapulmonary TB (L-ETB, 55%) and severe disseminated extrapulmonary TB (D-ETB, 50%). Terbium 77-79 interferon gamma Homo sapiens 24-33 26785981-10 2013 Within TB groups, ESAT6-IFN-gamma/CXCL9-based detection increased to 53% in PTB (p=0.031) and 54% in ETB (p=0.021), with comparable diagnosis in less severe extrapulmonary TB (L-ETB, 55%) and severe disseminated extrapulmonary TB (D-ETB, 50%). d-etb 231-236 interferon gamma Homo sapiens 24-33 23804808-5 2013 The increase in PTPase activity was confirmed by demonstrating that hBD-3 suppresses IFN-gamma-induced STAT1 tyrosine phosphorylation but not STAT1 serine and ERK1/2 threonine phosphorylation and stimulates the translocation of SHP-2 into the nucleus within 15 min. Tyrosine 109-117 interferon gamma Homo sapiens 85-94 23980846-0 2013 Black currant seed oil supplementation of mothers enhances IFN-gamma and suppresses IL-4 production in breast milk. seed oil 14-22 interferon gamma Homo sapiens 59-68 23661232-6 2013 Resveratrol significantly decreased both basal and interferon-gamma (IFN-gamma) (200 ng/ml)-stimulated levels of MCP-1, IL-6, and IL-8 and significantly attenuated both basal and IFN-gamma-stimulated activity of ERK. Resveratrol 0-11 interferon gamma Homo sapiens 51-67 23661232-6 2013 Resveratrol significantly decreased both basal and interferon-gamma (IFN-gamma) (200 ng/ml)-stimulated levels of MCP-1, IL-6, and IL-8 and significantly attenuated both basal and IFN-gamma-stimulated activity of ERK. Resveratrol 0-11 interferon gamma Homo sapiens 69-78 23661232-6 2013 Resveratrol significantly decreased both basal and interferon-gamma (IFN-gamma) (200 ng/ml)-stimulated levels of MCP-1, IL-6, and IL-8 and significantly attenuated both basal and IFN-gamma-stimulated activity of ERK. Resveratrol 0-11 interferon gamma Homo sapiens 179-188 23132777-8 2013 Paralleling hKv1.3 inhibition, curcumin significantly inhibited proliferation and interferon-gamma secretion of T(EM) cells. Curcumin 31-39 interferon gamma Homo sapiens 82-98 23732870-2 2013 One of the major mechanisms through which IFNgamma exerts these effects is by inducing expression of indoleamine 2,3 dioxygenase-1 (IDO1), an enzyme that catalyses the first, rate-limiting step of the kynurenine pathway. Kynurenine 201-211 interferon gamma Homo sapiens 42-50 23947692-2 2013 On immune system, imatinib has antiproliferative activity and immunomodulatory effects in lymphocytes, macrophages, mast cells and dendritic cells with abrogating multiple signal transduction pathways involved in pathogenesis of autoimmune diseases e.g. inhibiting IFN-gamma, TNF-alpha, IL-1beta and IL-17 pro-inflammatory cytokines and MMPs secretion. Imatinib Mesylate 18-26 interferon gamma Homo sapiens 265-274 23839943-4 2013 We report the impact of the homologous C1-C12 alcohol series on the ability of activated primary human lymphocytes to produce IFN-gamma. Alcohols 46-53 interferon gamma Homo sapiens 126-135 23732870-7 2013 Due to IFNgamma"s ability to induce IDO1 expression, kynurenine production can also be a measure of human IFNgamma (hIFNgamma) bioactivity. Kynurenine 53-63 interferon gamma Homo sapiens 106-114 23732870-7 2013 Due to IFNgamma"s ability to induce IDO1 expression, kynurenine production can also be a measure of human IFNgamma (hIFNgamma) bioactivity. Kynurenine 53-63 interferon gamma Homo sapiens 116-125 23839943-5 2013 Methanol enhanced IFN-gamma production whereas C2-C10 alcohols reduced the release of this cytokine. Methanol 0-8 interferon gamma Homo sapiens 18-27 23962110-7 2013 Importantly, arsenic/IFN/zidovudine therapy sharply diminished IL-10 transcript and serum levels concomittant with decrease in IL-4 and increases in IFN-gamma and IL-2 mRNA, whether or not values were adjusted to the percentage of CD4+CD25+ cells. Arsenic 13-20 interferon gamma Homo sapiens 149-158 23973990-7 2013 From a functional standpoint, IFN-g-challenged HL-60 cells promoted the in vitro conversion of allogeneic CD4+CD25- T cells into bona fide CD4+CD25+FoxP3+ regulatory T cells, an effect that was significantly reduced by treatment of IFN-gamma-activated HL-60 cells with nimesulide. nimesulide 269-279 interferon gamma Homo sapiens 30-35 23962110-7 2013 Importantly, arsenic/IFN/zidovudine therapy sharply diminished IL-10 transcript and serum levels concomittant with decrease in IL-4 and increases in IFN-gamma and IL-2 mRNA, whether or not values were adjusted to the percentage of CD4+CD25+ cells. Zidovudine 25-35 interferon gamma Homo sapiens 149-158 23890607-0 2013 A homogeneous hemin/G-quadruplex DNAzyme based turn-on chemiluminescence aptasensor for interferon-gamma detection via in-situ assembly of luminol functionalized gold nanoparticles, deoxyribonucleic acid, interferon-gamma and hemin. Luminol 139-146 interferon gamma Homo sapiens 88-104 23890607-2 2013 The G-quadruplex oligomer of the HGDNAzyme was split into two halves, which was connected with the complementary sequence of P1 (IFN-gamma-binding aptamer) to form the oligonucleotide P2. Oligonucleotides 168-183 interferon gamma Homo sapiens 129-138 23890607-0 2013 A homogeneous hemin/G-quadruplex DNAzyme based turn-on chemiluminescence aptasensor for interferon-gamma detection via in-situ assembly of luminol functionalized gold nanoparticles, deoxyribonucleic acid, interferon-gamma and hemin. Hemin 14-19 interferon gamma Homo sapiens 88-104 23890607-3 2013 P2 hybridized with IFN-gamma-binding aptamer and meanwhile assembled onto lum-AuNPs through biotin-streptavidin specific interaction. Biotin 92-98 interferon gamma Homo sapiens 19-28 23890607-0 2013 A homogeneous hemin/G-quadruplex DNAzyme based turn-on chemiluminescence aptasensor for interferon-gamma detection via in-situ assembly of luminol functionalized gold nanoparticles, deoxyribonucleic acid, interferon-gamma and hemin. Hemin 14-19 interferon gamma Homo sapiens 205-221 23890607-1 2013 A homogeneous hemin/G-quadruplex DNAzyme (HGDNAzyme) based turn-on chemiluminescence aptasensor for interferon-gamma (IFN-gamma) detection is developed, via dynamic in-situ assembly of luminol functionalized gold nanoparticles (lum-AuNPs), DNA, IFN-gamma and hemin. Luminol 185-192 interferon gamma Homo sapiens 100-116 23890607-1 2013 A homogeneous hemin/G-quadruplex DNAzyme (HGDNAzyme) based turn-on chemiluminescence aptasensor for interferon-gamma (IFN-gamma) detection is developed, via dynamic in-situ assembly of luminol functionalized gold nanoparticles (lum-AuNPs), DNA, IFN-gamma and hemin. Luminol 185-192 interferon gamma Homo sapiens 118-127 23768126-7 2013 Furthermore, poly I:C or CpG encapsulated in Ac-DEX also showed, in general, a significantly stronger immunostimulatory response than PLGA and unencapsulated CpG or poly I:C, which was indicated by a higher rate of nitric oxide release and increased levels of cytokines such as TNF-alpha, IL-6, IL-10, and IFN-gamma. Poly I-C 13-21 interferon gamma Homo sapiens 306-315 23768126-7 2013 Furthermore, poly I:C or CpG encapsulated in Ac-DEX also showed, in general, a significantly stronger immunostimulatory response than PLGA and unencapsulated CpG or poly I:C, which was indicated by a higher rate of nitric oxide release and increased levels of cytokines such as TNF-alpha, IL-6, IL-10, and IFN-gamma. ac-dex 45-51 interferon gamma Homo sapiens 306-315 23940564-5 2013 Patients with concurrent low levels of iNKT cells and IFN-gamma had a hazard ratio (HR) of 2.784 for OS and 2.673 for RFS. Osmium 101-103 interferon gamma Homo sapiens 54-63 23542336-9 2013 Also, serum 17beta-estradiol levels were positively correlated with IFN-gamma production, SOD activity and NGF expression in the PBMCs. Estradiol 12-28 interferon gamma Homo sapiens 68-77 23945888-9 2013 Mean concentration of interferon-gamma in tuberculosis group was significantly higher compared to non-tuberculosis group (69257 pg/l [range: 26600-148000] vs. 329 pg/l [range: 0-2200], P&lt;0.000). Adenosine Monophosphate 187-190 interferon gamma Homo sapiens 22-38 23607494-8 2013 Furthermore, poly(I:C) and proinflammatory cytokines [(IL-1beta, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha] induced IL-32 expression strongly in cultured BECs, accompanying the constant expression of TLR-3 and caspase 1. poly 13-17 interferon gamma Homo sapiens 65-87 23607494-8 2013 Furthermore, poly(I:C) and proinflammatory cytokines [(IL-1beta, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha] induced IL-32 expression strongly in cultured BECs, accompanying the constant expression of TLR-3 and caspase 1. Iodine 18-19 interferon gamma Homo sapiens 65-87 23607494-8 2013 Furthermore, poly(I:C) and proinflammatory cytokines [(IL-1beta, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha] induced IL-32 expression strongly in cultured BECs, accompanying the constant expression of TLR-3 and caspase 1. Carbon 20-21 interferon gamma Homo sapiens 65-87 23681904-9 2013 MRS-1754 blocked the antagonism of transforming growth factor beta (TGF-beta) in CIITA induction by interferon gamma (IFN-gamma), alluding to a potential dialogue between TGF-beta and adenosine signaling pathways. Adenosine 184-193 interferon gamma Homo sapiens 100-127 23793781-7 2013 Functionally, preterm compared to term CBMC secreted in response to phytohaemagglutinin lower IFN-gamma, higher IL-5 and similar IL-12p70, IL-10, IL-2 and IL-13 concentrations. cbmc 39-43 interferon gamma Homo sapiens 94-103 23727178-4 2013 In blood, ZEN increases the respiratory burst of monocytes and the inflammatory cytokine (TNF alpha, IL-1 beta, IFN gamma) synthesis, while in liver, ZEN decreases the synthesis of all inflammatory cytokines investigated. Zearalenone 10-13 interferon gamma Homo sapiens 112-121 23800860-4 2013 The patient was a 20-year-old man with homozygous 22Cdel in IFNGR1 resulting in complete absence of IFN-gammaR1 surface expression and complete lack of responsiveness to IFN-gamma in vitro. 22cdel 50-56 interferon gamma Homo sapiens 100-109 23657944-0 2013 NF-kappaB inhibition by bortezomib permits IFN-gamma-activated RIP1 kinase-dependent necrosis in renal cell carcinoma. Bortezomib 24-34 interferon gamma Homo sapiens 43-52 23359533-9 2013 Bosentan treatment was more effective than TGFbeta blockade in reversing the actions of IFN-gamma, including downregulation of alpha-SMA and TGFbeta2, suggesting that activation of the ET-1 pathway plays a main role in the IFN-gamma responses in HDMECs. Bosentan 0-8 interferon gamma Homo sapiens 88-97 23359533-9 2013 Bosentan treatment was more effective than TGFbeta blockade in reversing the actions of IFN-gamma, including downregulation of alpha-SMA and TGFbeta2, suggesting that activation of the ET-1 pathway plays a main role in the IFN-gamma responses in HDMECs. Bosentan 0-8 interferon gamma Homo sapiens 223-232 23817417-6 2013 Importantly, treatment with celecoxib, a COX-2 inhibitor, resulted in significantly lower PGE2 and IL-17A, but not IFN-gamma, production. Celecoxib 28-37 interferon gamma Homo sapiens 115-124 23657944-5 2013 Here, we show that the proteasome inhibitor bortezomib (PS-341, Velcade) sensitizes otherwise resistant RCC cells to direct necrotic death by IFN-gamma. Bortezomib 44-54 interferon gamma Homo sapiens 142-151 23657944-5 2013 Here, we show that the proteasome inhibitor bortezomib (PS-341, Velcade) sensitizes otherwise resistant RCC cells to direct necrotic death by IFN-gamma. Bortezomib 56-62 interferon gamma Homo sapiens 142-151 23657944-5 2013 Here, we show that the proteasome inhibitor bortezomib (PS-341, Velcade) sensitizes otherwise resistant RCC cells to direct necrotic death by IFN-gamma. Bortezomib 64-71 interferon gamma Homo sapiens 142-151 23540607-0 2013 Effects of sodium selenite on the decreased percentage of T cell subsets, contents of serum IL-2 and IFN-gamma induced by aflatoxin B1 in broilers. Aflatoxin B1 122-134 interferon gamma Homo sapiens 101-110 23707273-8 2013 Direct stimulation of peritoneal macrophages with rosiglitazone also increased HO-1 induction in the presence of lipopolysaccharide/interferon-gamma. Rosiglitazone 50-63 interferon gamma Homo sapiens 132-148 23895055-7 2013 Using HUVECs we demonstrated that tylophorine inhibited VEGF-stimulated inflammatory responses including IL-6, IL-8, TNF-alpha, IFN-gamma, MMP-2 and NO secretion. tylophorine 34-45 interferon gamma Homo sapiens 128-137 23772882-5 2013 TNF-alpha, IFN-gamma, IL-4, IL-5, and G-CSF levels were significantly higher (p values < 0.05 for all) in plasma with EDTA, whereas the levels of IL-6, IL-8, IL-10, IL-17, MIP-1beta, GM-CSF and MCP-1 were found to be significantly higher (p values < 0.05 for all) in plasma with heparin. Edetic Acid 121-125 interferon gamma Homo sapiens 11-20 23998596-6 2013 The results showed that the proportions of blood Th17 cells and concentration of blood serum IL-17 and IFN-gamma increased in patients with SAA, compared with MAA and normal controls, but CD4(+) CD25(+) Foxp3(+) Treg cells obviously decreased in patients with SAA. saa 140-143 interferon gamma Homo sapiens 103-112 23998596-7 2013 The concentrations of IL-17 and IFN-gamma significantly increased in culture supernatant of SAA group. saa 92-95 interferon gamma Homo sapiens 32-41 23922848-4 2013 First, we confirmed that IFNgamma-stimulation of transfected cells led to enhanced tyrosine phosphorylation of mutant STAT1 as compared to the wild-type protein, which consequently resulted in its prolonged nuclear accumulation. Tyrosine 83-91 interferon gamma Homo sapiens 25-33 23898330-7 2013 Our studies have resulted in the development of a non-canonical, more complex model of IFNgamma signaling that is akin to that of steroid hormone (SH)/steroid receptor (SR) signaling. Steroids 130-145 interferon gamma Homo sapiens 87-95 23882269-9 2013 Under both oxygen levels ASC were capable of strong upregulation of the immunomodulatory molecules indoleamine 2,3-dioxygenase (IDO) and programed death ligand-1 upon stimulation with IFN-gamma and TNF-alpha, and, in addition, IDO activity as measured by the accumulation of l-kynurenine was not affected under hypoxia. Oxygen 11-17 interferon gamma Homo sapiens 184-193 23844808-9 2013 In CD and T-CD, the expression of IL-10, IFN-g and CXCR6 were higher as compared to HC. t-cd 10-14 interferon gamma Homo sapiens 41-46 23738920-11 2013 Butyl benzyl phthalate or diethylhexyl phthalate-treated pDCs suppressed IFN-gamma but enhanced IL-13 production by CD4+ T cells. butylbenzyl phthalate 0-22 interferon gamma Homo sapiens 73-82 23738920-11 2013 Butyl benzyl phthalate or diethylhexyl phthalate-treated pDCs suppressed IFN-gamma but enhanced IL-13 production by CD4+ T cells. Diethylhexyl Phthalate 26-48 interferon gamma Homo sapiens 73-82 23597432-0 2013 Tryptophan metabolism and immunogenetics in major depression: a role for interferon-gamma gene. Tryptophan 0-10 interferon gamma Homo sapiens 73-89 23597432-2 2013 The pro-inflammatory cytokine interferon-gamma transcriptionally induces the indoleamine 2,3-dioxygenase enzyme that degrades the tryptophan and thus induces serotonin depletion. Tryptophan 130-140 interferon gamma Homo sapiens 30-46 23597432-2 2013 The pro-inflammatory cytokine interferon-gamma transcriptionally induces the indoleamine 2,3-dioxygenase enzyme that degrades the tryptophan and thus induces serotonin depletion. Serotonin 158-167 interferon gamma Homo sapiens 30-46 23597432-6 2013 The presence of IFNgamma CA repeat allele 2 homozygous has significant association with higher kynurenine concentrations in controls (F=4.47, p=0.038) as well as in patients (F=3.79, p=0.045). Kynurenine 95-105 interferon gamma Homo sapiens 16-24 23597432-7 2013 The existence of interferon-gamma CA repeat allele 2 (homo- or heterozygous) showed significant association with increase of tryptophan breakdown over time during the study period (F=6.0, p=0.019). Tryptophan 125-135 interferon gamma Homo sapiens 17-33 23597432-8 2013 The results indicated the association between IFNgamma CA repeat allele 2, tryptophan metabolism and the effect of medication. Tryptophan 75-85 interferon gamma Homo sapiens 46-54 23754498-1 2013 Indoleamine 2,3-dioxygenase (IDO) is an interferon-gamma (IFN-gamma)-induced tryptophan-degrading enzyme, producing kynurenine (KYN) that participates in the mechanism of tumor immune tolerance. Tryptophan 77-87 interferon gamma Homo sapiens 40-56 23633486-9 2013 Indeed, PGE2 was sufficient to confer to monocytes the ability to suppress proliferation and IFN-gamma production by autologous T cells ex vivo. Dinoprostone 8-12 interferon gamma Homo sapiens 93-102 23636127-5 2013 Treatment of T cells from immunosuppressed glioblastoma patients with miR-124 induced marked effector response including upregulation of interleukin (IL)-2, IFN-gamma, and TNF-alpha. mir-124 70-77 interferon gamma Homo sapiens 157-166 23916683-6 2013 Addition of the ROS inhibitor DPI decreased the T cell proliferation and IFN-gamma production. Reactive Oxygen Species 16-19 interferon gamma Homo sapiens 73-82 23916683-6 2013 Addition of the ROS inhibitor DPI decreased the T cell proliferation and IFN-gamma production. 3-aminodiphenyleneiodium 30-33 interferon gamma Homo sapiens 73-82 23636788-5 2013 IFN-beta produced by poly I:C-activated human cancer cells increased the capacity of monocyte-derived DCs to stimulate IFN-gamma production in an allogeneic stimulatory culture in vitro. Poly I 21-27 interferon gamma Homo sapiens 119-128 23754498-1 2013 Indoleamine 2,3-dioxygenase (IDO) is an interferon-gamma (IFN-gamma)-induced tryptophan-degrading enzyme, producing kynurenine (KYN) that participates in the mechanism of tumor immune tolerance. Tryptophan 77-87 interferon gamma Homo sapiens 58-67 23754498-1 2013 Indoleamine 2,3-dioxygenase (IDO) is an interferon-gamma (IFN-gamma)-induced tryptophan-degrading enzyme, producing kynurenine (KYN) that participates in the mechanism of tumor immune tolerance. Kynurenine 116-126 interferon gamma Homo sapiens 40-56 23754498-1 2013 Indoleamine 2,3-dioxygenase (IDO) is an interferon-gamma (IFN-gamma)-induced tryptophan-degrading enzyme, producing kynurenine (KYN) that participates in the mechanism of tumor immune tolerance. Kynurenine 116-126 interferon gamma Homo sapiens 58-67 23754498-1 2013 Indoleamine 2,3-dioxygenase (IDO) is an interferon-gamma (IFN-gamma)-induced tryptophan-degrading enzyme, producing kynurenine (KYN) that participates in the mechanism of tumor immune tolerance. Kynurenine 128-131 interferon gamma Homo sapiens 40-56 23754498-1 2013 Indoleamine 2,3-dioxygenase (IDO) is an interferon-gamma (IFN-gamma)-induced tryptophan-degrading enzyme, producing kynurenine (KYN) that participates in the mechanism of tumor immune tolerance. Kynurenine 128-131 interferon gamma Homo sapiens 58-67 23630965-10 2013 Pretreatment with Y-27632 inhibited the sepsis-induced decrease in IFN-gamma but not IL-4 formation in the spleen. Y 27632 18-25 interferon gamma Homo sapiens 67-76 22840925-0 2013 "In vitro" azathioprine-induced changes in peripheral T cell apoptosis and IFN-gamma production associate with drug response in patients with Crohn"s Disease. Azathioprine 11-23 interferon gamma Homo sapiens 75-84 23729439-0 2013 Inhibition of histone deacetylase activity suppresses IFN-gamma induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1. tripartite 77-87 interferon gamma Homo sapiens 54-63 22840925-10 2013 CONCLUSIONS: Evaluation of apoptosis and IFN-gamma stimulation index of peripheral CD4+ T cell may be useful for a proper selection of CD patients candidate to thiopurine treatment. 2-mercaptopyrazine 160-170 interferon gamma Homo sapiens 41-50 23729439-7 2013 Moreover, carboxyl terminus of Hsc70-interacting protein was found to be involved in the TSA-mediated inhibitory effect on IFN-gamma induction of TRIM22 as well as other IRF-1-dependent IFN-stimulated genes. trichostatin A 89-92 interferon gamma Homo sapiens 123-132 23616666-9 2013 The advantage of Gag-specific cells may result from their enhanced ability to mediate lysis of infected cells (evidenced by a higher capacity to degranulate and to mediate VIA) and to simultaneously produce IFN-gamma. Glycosaminoglycans 17-20 interferon gamma Homo sapiens 207-216 24069555-2 2013 The paper by Joanna Bancerek and colleagues published recently in Immunity reports that upon interferon-gamma (IFNgamma) stimulation of cells the chromatin-associated cyclin-dependent kinase 8 (CDK8) phosphorylates the regulatory serine residue 727 in the transactivation domain of STAT1. Serine 230-236 interferon gamma Homo sapiens 93-109 24069555-2 2013 The paper by Joanna Bancerek and colleagues published recently in Immunity reports that upon interferon-gamma (IFNgamma) stimulation of cells the chromatin-associated cyclin-dependent kinase 8 (CDK8) phosphorylates the regulatory serine residue 727 in the transactivation domain of STAT1. Serine 230-236 interferon gamma Homo sapiens 111-119 23824716-6 2013 Th1 cytokines were significantly higher in TB-Treated, and the levels of IFN-gamma and TNF-alpha increased continuously after clinical cure. Terbium 43-45 interferon gamma Homo sapiens 73-82 23567618-7 2013 Mitogen-activated protein/extracellular signal-regulated kinase inhibitor U0126 abrogated TNF-alpha-, IFN-gamma-, and IL-1beta-induced and Janus-activated kinase inhibitor I reduced IFN-gamma-induced IL-33 production. U 0126 74-79 interferon gamma Homo sapiens 102-111 23953575-8 2013 Consistent with the above data, serum cytokine levels of IL-2, IFN-gamma and TNF-alpha were significantly decreased at day +7 posttransplantation after two doses of bortezomib compared with aGVHD control group. Bortezomib 165-175 interferon gamma Homo sapiens 63-72 23734709-0 2013 Insights into the mechanism by which interferon-gamma basic amino acid clusters mediate protein binding to heparan sulfate. Amino Acids, Basic 54-70 interferon gamma Homo sapiens 37-53 23734709-0 2013 Insights into the mechanism by which interferon-gamma basic amino acid clusters mediate protein binding to heparan sulfate. Heparitin Sulfate 107-122 interferon gamma Homo sapiens 37-53 23734709-2 2013 To understand the forces that drive such interactions the binding of heparin to interferon-gamma (IFNgamma), used as a model system, was investigated. Heparin 69-76 interferon gamma Homo sapiens 80-96 23734709-2 2013 To understand the forces that drive such interactions the binding of heparin to interferon-gamma (IFNgamma), used as a model system, was investigated. Heparin 69-76 interferon gamma Homo sapiens 98-106 23391707-0 2013 A highly sensitive label-free electrochemical aptasensor for interferon-gamma detection based on graphene controlled assembly and nuclease cleavage-assisted target recycling amplification. Graphite 97-105 interferon gamma Homo sapiens 61-77 23391707-1 2013 We report here a highly sensitive and label-free electrochemical aptasensing technology for detection of interferon-gamma (IFN-gamma) based on graphene controlled assembly and enzyme cleavage-assisted target recycling amplification strategy. Graphite 143-151 interferon gamma Homo sapiens 105-121 23391707-1 2013 We report here a highly sensitive and label-free electrochemical aptasensing technology for detection of interferon-gamma (IFN-gamma) based on graphene controlled assembly and enzyme cleavage-assisted target recycling amplification strategy. Graphite 143-151 interferon gamma Homo sapiens 123-132 23391707-2 2013 In this work, in the absence of IFN-gamma, the graphene could not be assembled onto the 16-mercaptohexadecanoic acid (MHA) modified gold electrode because the IFN-gamma binding aptamer was strongly adsorbed on the graphene due to the strong pi-pi interaction. Graphite 47-55 interferon gamma Homo sapiens 159-168 23391707-2 2013 In this work, in the absence of IFN-gamma, the graphene could not be assembled onto the 16-mercaptohexadecanoic acid (MHA) modified gold electrode because the IFN-gamma binding aptamer was strongly adsorbed on the graphene due to the strong pi-pi interaction. Graphite 214-222 interferon gamma Homo sapiens 159-168 23391707-4 2013 However, the presence of target IFN-gamma and DNase I led to desorption of aptamer from the graphene surface and further cleavage of the aptamer, thereby releasing the IFN-gamma. Graphite 92-100 interferon gamma Homo sapiens 32-41 23391707-4 2013 However, the presence of target IFN-gamma and DNase I led to desorption of aptamer from the graphene surface and further cleavage of the aptamer, thereby releasing the IFN-gamma. Graphite 92-100 interferon gamma Homo sapiens 168-177 23391707-5 2013 The released IFN-gamma could then re-attack other aptamers on the graphene, resulting in the successive release of the aptamers from the graphene. Graphite 66-74 interferon gamma Homo sapiens 13-22 23391707-5 2013 The released IFN-gamma could then re-attack other aptamers on the graphene, resulting in the successive release of the aptamers from the graphene. Graphite 137-145 interferon gamma Homo sapiens 13-22 23391707-8 2013 By taking advantages of graphene and enzyme cleavage-assisted target recycling amplification, the developed label-free electrochemical aptasensing technology showed a linear response to concentration of IFN-gamma range from 0.1 to 0.7 pM. Graphite 24-32 interferon gamma Homo sapiens 203-212 23686490-9 2013 Downregulation of ABCA1 expression correlated with decreased cholesterol efflux to apolipoprotein A1 in macrophages stimulated with IFN-gamma. Cholesterol 61-72 interferon gamma Homo sapiens 132-141 23470621-4 2013 Hyperoxia-induced and IFN-gamma-mediated impaired alveolarization was rescued by Cox2 inhibition, using celecoxib. Celecoxib 104-113 interferon gamma Homo sapiens 22-31 23554061-6 2013 A single trivalent acetylated mannobiose derivative was identified as a potent inducer of Treg and Th1 immune response, resulting in strong IL-10 and moderate IFN-gamma productions dose-dependently, while inducing no Th2 cytokine response. mannobiose 30-40 interferon gamma Homo sapiens 159-168 23499872-4 2013 Cambinol inhibited the expression of cytokines (TNF, IL-1beta, IL-6, IL-12p40, and IFN-gamma), NO and CD40 by macrophages, dendritic cells, splenocytes and whole blood stimulated with a broad range of microbial and inflammasome stimuli. cambinol 0-8 interferon gamma Homo sapiens 83-92 23600826-7 2013 Similarly, co-incubation of fatty acids with glucose diminished secretion of IL-10, IFN-gamma and CCL2 (monocyte chemotactic protein-1), while IL-8 was up-regulated (P < 0 001). Fatty Acids 28-39 interferon gamma Homo sapiens 84-93 23149858-8 2013 As a result, we found that DMH-treated animals were having over-expression of various pro-inflammatory cytokines (IL-1beta, IL-2, and IFNgamma), aberrant nuclear localization of activated cell survival transcription factors (NF-kappaB and Stat3) along with the increased incidence of activated angiogenic factors (MMP-2 and MMP-9) suggesting a marked role of inflammation in the tumor progression. 1,2-Dimethylhydrazine 27-30 interferon gamma Homo sapiens 134-142 23600826-7 2013 Similarly, co-incubation of fatty acids with glucose diminished secretion of IL-10, IFN-gamma and CCL2 (monocyte chemotactic protein-1), while IL-8 was up-regulated (P < 0 001). Glucose 45-52 interferon gamma Homo sapiens 84-93 23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Fatty Acids 17-28 interferon gamma Homo sapiens 102-111 23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Uric Acid 34-43 interferon gamma Homo sapiens 102-111 23692034-0 2013 CD4(+) T cells producing interleukin (IL)-17, IL-22 and interferon-gamma are major effector T cells in nickel allergy. Nickel 103-109 interferon gamma Homo sapiens 56-72 23424039-9 2013 NK cells activated by sorafenib-treated Mphi showed increased degranulation (15.3 +- 0.2% versus 32.0 +- 0.9%, P < 0.0001) and interferon-gamma (IFN-gamma) secretion (2.1 +- 0.2% versus 8.0 +- 0.2%, P < 0.0001) upon target cell contact. Sorafenib 22-31 interferon gamma Homo sapiens 130-146 23692034-6 2013 In nickel-allergic patients, there was massive cellular infiltration dominated by CD4(+) T cells producing IL-17, IL-22 and IFN-gamma in nickel-challenged skin but not in vehicle-challenged skin. Nickel 3-9 interferon gamma Homo sapiens 124-133 23692034-7 2013 CONCLUSION: CD4(+) T cells producing IL-17, IL-22 and IFN-gamma are important effector cells in the eczematous reactions of nickel-induced allergic contact dermatitis in humans. Nickel 124-130 interferon gamma Homo sapiens 54-63 23200035-8 2013 9-R-HODE but not any other lipid increased the percentages of NK cells producing IFN-gamma and is the only lipid that enhanced the release of this cytokine by these cells. 9-r-hode 0-8 interferon gamma Homo sapiens 81-90 23424039-9 2013 NK cells activated by sorafenib-treated Mphi showed increased degranulation (15.3 +- 0.2% versus 32.0 +- 0.9%, P < 0.0001) and interferon-gamma (IFN-gamma) secretion (2.1 +- 0.2% versus 8.0 +- 0.2%, P < 0.0001) upon target cell contact. Sorafenib 22-31 interferon gamma Homo sapiens 148-157 23129404-12 2013 In response to PMA/ionomycin stimulation, the proportion of IFN-gamma expressing NK-92 cells increased with 100 and 200 ng/ml of leptin. Ionomycin 19-28 interferon gamma Homo sapiens 60-69 23856572-6 2013 Various modeling approaches were used to define IFN-gamma trajectories and correlations with TB exposure. Terbium 93-95 interferon gamma Homo sapiens 48-57 23616576-9 2013 Collectively, these data show that Lys-313 in the T-box domain is essential for controlling T-bet protein stability via ubiquitin-dependent degradation, T-bet binding to the IFN-gamma promoter, and for the interaction with and suppression of NFAT1. Lysine 35-38 interferon gamma Homo sapiens 174-183 23489467-4 2013 A significant decrease in IFNgamma and increase in IL-10 in endocervical fluid was seen when the values were compared before and after progesterone treatment. Progesterone 135-147 interferon gamma Homo sapiens 26-34 22351517-8 2013 When applied alone, CpdA increased the epidermal thickness and keratinocyte proliferation as well as levels of c-jun, COX-2, IL-6, and IFN-gamma. CPDA 20-24 interferon gamma Homo sapiens 135-144 23551080-8 2013 However, after the heterozygote PMNs had been incubated with IFN-gamma (100 U/ml) for 2 h, both the proportion of cells responding and the size of the CRP-induced calcium signals increased. Calcium 163-170 interferon gamma Homo sapiens 61-70 23589028-0 2013 Interferon-gamma enhances phorbol myristate acetate-induced cell attachment and tumor necrosis factor production via the NF-kappaB pathway in THP-1 human monocytic cells. Tetradecanoylphorbol Acetate 26-51 interferon gamma Homo sapiens 0-16 23589028-9 2013 Accordingly, the NF-kappaB pathway inhibitor (BAY 11-7082) inhibited the enhancing effect of IFN-gamma on adhesion and TNF production. 3-(4-methylphenylsulfonyl)-2-propenenitrile 46-57 interferon gamma Homo sapiens 93-102 23308012-4 2013 The objective of this study was to examine the modulation of the gene expression of T-bet and GATA-3, and of the cytokines interferon gamma (IFN-gamma) and interleukin 4 (IL-4), by female steroid hormones, in human endometrial stromal cells (HESC) in long-term cultures (30 days) mimicking the normal menstrual cycle. Steroids 188-204 interferon gamma Homo sapiens 123-150 23551080-13 2013 However, increased expression of FcgammaRIa (CD64), stimulated by IFN-gamma, can augment calcium signalling by CRP in low-responders. Calcium 89-96 interferon gamma Homo sapiens 66-75 23481478-7 2013 Acenocoumarol had no effect in unstimulated cells but in PHA-stimulated PBMC tryptophan breakdown and the formation of neopterin, as well as IFN-gamma and TNF-alpha, were dose-dependently suppressed at concentrations as low as 10 mug/ml. Acenocoumarol 0-13 interferon gamma Homo sapiens 141-150 23535363-0 2013 Interferon-gamma promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma. 4,4'-diphenylmethane diisocyanate 86-98 interferon gamma Homo sapiens 0-16 23535363-7 2013 Results showed that relative methylation of IFN-gamma promoter was significantly increased in DA+ in comparison with both comparator groups (DA- and AW), and it exhibited good sensitivity (77.5%) and specificity (80%) for identifying DA workers in a multivariate predictive model after adjusting for type of DI exposure, smoking status, methacholine PC20, and gender. Methacholine Chloride 337-349 interferon gamma Homo sapiens 44-53 23769052-7 2013 Interferon (IFN)-gamma production was induced only by PMA/ionomycin (P < .01) but not by PHA (P = NS). Tetradecanoylphorbol Acetate 54-57 interferon gamma Homo sapiens 0-22 23769052-7 2013 Interferon (IFN)-gamma production was induced only by PMA/ionomycin (P < .01) but not by PHA (P = NS). Ionomycin 58-67 interferon gamma Homo sapiens 0-22 23769052-11 2013 Similar to Treg, IFN-gamma-secreting Ts were detected only during PMA/ionomycin stimulation (P < .01), but not during PHA stimulation (P = NS). Ionomycin 70-79 interferon gamma Homo sapiens 17-26 23481478-8 2013 Likewise, acenocoumarol dose-dependently inhibited tryptophan breakdown in IFN-gamma stimulated Caco-2 cells. Acenocoumarol 10-23 interferon gamma Homo sapiens 75-84 23481478-8 2013 Likewise, acenocoumarol dose-dependently inhibited tryptophan breakdown in IFN-gamma stimulated Caco-2 cells. Tryptophan 51-61 interferon gamma Homo sapiens 75-84 23705001-9 2013 Cell death induced by H2O2 or NaIO3 was preceded by mitochondrial dysfunction and by p62 upregulation, both of which were attenuated by PCM and/or by IFNgamma+TNFalpha. Hydrogen Peroxide 22-26 interferon gamma Homo sapiens 150-158 23705001-9 2013 Cell death induced by H2O2 or NaIO3 was preceded by mitochondrial dysfunction and by p62 upregulation, both of which were attenuated by PCM and/or by IFNgamma+TNFalpha. sodium iodate 30-35 interferon gamma Homo sapiens 150-158 23580655-0 2013 Wedelolactone, a naturally occurring coumestan, enhances interferon-gamma signaling through inhibiting STAT1 protein dephosphorylation. wedelolactone 0-13 interferon gamma Homo sapiens 57-73 23580655-0 2013 Wedelolactone, a naturally occurring coumestan, enhances interferon-gamma signaling through inhibiting STAT1 protein dephosphorylation. coumestan 37-46 interferon gamma Homo sapiens 57-73 23580655-3 2013 We discovered a natural compound, wedelolactone, that increased IFN-gamma signaling by inhibiting STAT1 dephosphorylation and prolonging STAT1 activation through specific inhibition of T-cell protein tyrosine phosphatase (TCPTP), an important tyrosine phosphatase for STAT1 dephosphorylation. wedelolactone 34-47 interferon gamma Homo sapiens 64-73 23717811-15 2013 An analog of thalidomide, CC-5103 increases the secretion of critical cytokines of the tumor microenvironment, including IL-2, IFN-gamma, TNF-alpha, and IL-10, and is currently being evaluated in clinical trials for the treatment of recurrent or refractory pediatric central nervous system tumors. Thalidomide 13-24 interferon gamma Homo sapiens 127-136 23755049-8 2013 In vitro stimulation with IL-2 and TLR2 agonists (lipoteichoic acid, and synthetic triacylated lipopeptide Pam3CSK4) enhanced IFNgamma-secretion, degranulation, and cytotoxicity mediated by NK cells isolated pre-exercise, but had less effect on NK cells isolated following exercise. lipoteichoic acid 50-67 interferon gamma Homo sapiens 126-134 23675474-2 2013 In human cells the interferon-gamma (IFN-gamma) inducible enzyme indoleamine 2,3-dioxygenase (IDO) reduces local tryptophan levels and is therefore able to mediate broad-spectrum effector functions: IDO activity restricts the growth of various clinically relevant pathogens such as bacteria, parasites and viruses. Tryptophan 113-123 interferon gamma Homo sapiens 19-35 23675474-2 2013 In human cells the interferon-gamma (IFN-gamma) inducible enzyme indoleamine 2,3-dioxygenase (IDO) reduces local tryptophan levels and is therefore able to mediate broad-spectrum effector functions: IDO activity restricts the growth of various clinically relevant pathogens such as bacteria, parasites and viruses. Tryptophan 113-123 interferon gamma Homo sapiens 37-46 23478509-5 2013 A good linear relationship existed between the pixel intensity and the human IFNgamma concentrations from 10-1000 ng mL(-1) in mouse serum and buffer, respectively, the regression equation was Y = 0.159logX + 0.0648, R(2) = 0.992 in mouse serum; Y = 0.294logX + 0.091, R(2) = 0.9969 in phosphate buffer by this proposed strip. Phosphates 286-295 interferon gamma Homo sapiens 77-85 23506849-5 2013 The paquinimod-induced amelioration correlated with reduced priming of antigen-specific CD4(+) T cells and reduced frequency of IFN-gamma- and IL-17-producing cells in draining lymph nodes. paquinimod 4-14 interferon gamma Homo sapiens 128-137 23325275-6 2013 Bezafibrate treatment for at least 4 months markedly increased interferon-gamma expression compared with the treatment-naive patients (4.81 vs. 1.63 arbitrary units; P=0.005), whereas tumour necrosis factor-alpha and interleukin-6 levels were not significantly influenced. Bezafibrate 0-11 interferon gamma Homo sapiens 63-79 23671580-0 2013 Amelioration of IFN-gamma and TNF-alpha-induced intestinal epithelial barrier dysfunction by berberine via suppression of MLCK-MLC phosphorylation signaling pathway. Berberine 93-102 interferon gamma Homo sapiens 16-25 23671580-4 2013 In this study, we investigate the protective actions of berberine on barrier function and the underlying mechanisms in Caco-2 monolayers challenged with IFN-gamma and TNF-alpha. Berberine 56-65 interferon gamma Homo sapiens 153-162 23671580-10 2013 The results showed that berberine significantly attenuated TER decrease and paracellular permeability increase in Caco-2 monolayers treated with IFN-gamma and TNF-alpha. Berberine 24-33 interferon gamma Homo sapiens 145-154 23671580-11 2013 Berberine also dramatically alleviated IFN-gamma and TNF-alpha-induced morphological alteration of tight junction proteins ZO-1, occluding, and claudin-1. Berberine 0-9 interferon gamma Homo sapiens 39-48 23671580-12 2013 The increase of both MLC phosphorylation and MLCK protein expression induced by IFN-gamma and TNF-alpha was significantly inhibited by berberine treatment. Berberine 135-144 interferon gamma Homo sapiens 80-89 23671580-14 2013 Taken together, it is suggested that berberine attenuates IFN-gamma and TNF-alpha-induced intestinal epithelial barrier dysfunction by inhibiting the signaling pathway of MLCK-dependent MLC phosphorylation mediated by HIF-1alpha. Berberine 37-46 interferon gamma Homo sapiens 58-67 23289765-3 2013 Given that IFN-gamma activates a vitamin D-dependent antimicrobial response, we focused on induction of the key components of this pathway. Vitamin D 33-42 interferon gamma Homo sapiens 11-20 23289765-4 2013 We show that activation of human monocytes via CD40 ligand (CD40L) and IFN-gamma, alone, and in combination, induces the CYP27b1-hydroxylase, responsible for the conversion of 25-hydroxyvitamin D (25D) to the bioactive 1,25-dihydroxyvitamin D (1,25D), and the vitamin D receptor (VDR). 25-hydroxyvitamin D 176-195 interferon gamma Homo sapiens 71-80 23289765-4 2013 We show that activation of human monocytes via CD40 ligand (CD40L) and IFN-gamma, alone, and in combination, induces the CYP27b1-hydroxylase, responsible for the conversion of 25-hydroxyvitamin D (25D) to the bioactive 1,25-dihydroxyvitamin D (1,25D), and the vitamin D receptor (VDR). 1,25-dihydroxyvitamin D 219-242 interferon gamma Homo sapiens 71-80 23289765-5 2013 The activation of the vitamin D pathway by CD40L and IFN-gamma results in up-regulated expression of the antimicrobial peptides, cathelicidin and DEFB4, as well as induction of autophagy. Vitamin D 22-31 interferon gamma Homo sapiens 53-62 23289765-7 2013 Our data suggest that at least two parallel T-cell-mediated mechanisms, CD40L and IFN-gamma, activate the vitamin D-dependent antimicrobial pathway and trigger antimicrobial activity against intracellular M. tuberculosis, thereby contributing to human host defence against intracellular infection. Vitamin D 106-115 interferon gamma Homo sapiens 82-91 23727477-4 2013 In the present study, we demonstrate that IL-27 inhibits the production of IL-22 and induces the expression of IFN-gamma in CD4(+) T cells from human umbilical cord blood mononuclear cells (CBMCs) stimulated with anti-CD3 and anti-CD28 in dose-dependent manner. cbmcs 190-195 interferon gamma Homo sapiens 111-120 23536633-8 2013 Further, blockade of fatty-acid synthesis increased DC expression of Notch ligands and enhanced their ability to activate NK cell immune phenotype and IFN-gamma production. Fatty Acids 21-31 interferon gamma Homo sapiens 151-160 23726607-6 2013 The intensity of TNF-alpha and IFN-gamma in ARG (144.47 +- 81.21 and 116.61 +- 53.89, respectively) was significant higher than STA (P < .001). Arginine 44-47 interferon gamma Homo sapiens 31-40 23562757-6 2013 In contrast, as compared with control, the secretion of IL-12p40, IL-23 and IL-6 was lower from AEE-DCs and 2Ph-CDs and allogeneic CD4(+) T cells co-cultured with these DCs secreted lower levels of IFN-gamma and IL-10 but the same levels of IL-17. aspirin eugenol ester 96-99 interferon gamma Homo sapiens 198-207 23562757-7 2013 These results demonstrate that AEE and 2Ph affect the stimulation of DCs and their ability to stimulate allogeneic CD4(+) T cells by reducing the production of IFN-gamma, IL-12 p40, IL-6 and IL-23. aspirin eugenol ester 31-34 interferon gamma Homo sapiens 160-169 23562757-7 2013 These results demonstrate that AEE and 2Ph affect the stimulation of DCs and their ability to stimulate allogeneic CD4(+) T cells by reducing the production of IFN-gamma, IL-12 p40, IL-6 and IL-23. UNII-H4K6WCP5DQ 39-42 interferon gamma Homo sapiens 160-169 23726630-5 2013 The immunosuppressive therapy was monitored pre- and posttransplantation at 4, 12, and 24 months using triple fluorescence flow cytometry for intracellular interleukin (Il)-2 Il-4 and interferon (IFN)-gamma production in phorbol myristate acetate- and lipopolysaccharide- stimulated lymphocyte cultures. Tetradecanoylphorbol Acetate 221-246 interferon gamma Homo sapiens 184-206 23726607-8 2013 The intensity in noncultured plasma from ARG or STA was significant lower than that in culture supernates from ARG and STA with sensitivity and specificity to predict acute rejection episodes of 63.6% and 73.3%, respectively, when combining TNF-alpha and IFN-gamma. Arginine 41-44 interferon gamma Homo sapiens 255-264 23726607-8 2013 The intensity in noncultured plasma from ARG or STA was significant lower than that in culture supernates from ARG and STA with sensitivity and specificity to predict acute rejection episodes of 63.6% and 73.3%, respectively, when combining TNF-alpha and IFN-gamma. sta 48-51 interferon gamma Homo sapiens 255-264 23726607-8 2013 The intensity in noncultured plasma from ARG or STA was significant lower than that in culture supernates from ARG and STA with sensitivity and specificity to predict acute rejection episodes of 63.6% and 73.3%, respectively, when combining TNF-alpha and IFN-gamma. sta 119-122 interferon gamma Homo sapiens 255-264 23726607-9 2013 CONCLUSIONS: Monitoring the expression of TNF-alpha and IFN-gamma in cell culture supernates after stimulation of kidney transplant recipient PBL in vitro using FCMA predicted acute rejection episodes. fcma 161-165 interferon gamma Homo sapiens 56-65 23631691-11 2013 CONCLUSIONS: We found that HP was a stronger inducer of TLR 3, 7, and 8 expression and IL-1beta, IL-6, TNF-alpha, and IFN-gamma production compared to LP and LP-der. histidylproline 27-29 interferon gamma Homo sapiens 118-127 23416458-5 2013 Higher levels of IL-17 and IFN-gamma were produced by stimulation with PMA/Ionomycin compared to anti-CD3/anti-CD28. Tetradecanoylphorbol Acetate 71-74 interferon gamma Homo sapiens 27-36 23416458-5 2013 Higher levels of IL-17 and IFN-gamma were produced by stimulation with PMA/Ionomycin compared to anti-CD3/anti-CD28. Ionomycin 75-84 interferon gamma Homo sapiens 27-36 23416458-8 2013 Furthermore the dose response curve for PMA/Ionomycin differed for IL-10 compared to IL-17 and IFN-gamma as it was biphasic with no IL-10 production at higher PMA/Ionomycin concentrations. Tetradecanoylphorbol Acetate 40-43 interferon gamma Homo sapiens 95-104 23416458-8 2013 Furthermore the dose response curve for PMA/Ionomycin differed for IL-10 compared to IL-17 and IFN-gamma as it was biphasic with no IL-10 production at higher PMA/Ionomycin concentrations. Ionomycin 44-53 interferon gamma Homo sapiens 95-104 23638187-7 2013 Blockage of CD244/2B4 signaling pathway of T cells from patients with active TB resulted in significantly increased production of IFN-gamma, compared with isotype antibody control. Terbium 77-79 interferon gamma Homo sapiens 130-139 23629966-6 2013 IFN-gamma-induced interaction of HDAC1 and p53 resulted in the deacetylation of p53 and suppression of Bmf expression independent of p53"s proline-rich domain. Proline 139-146 interferon gamma Homo sapiens 0-9 23626814-9 2013 The concentrations of sIL-2R, IL-6, TNF-alpha, IFN-gamma in TB patients with or without COPD and COPD patients without TB were significantly higher than those in control group. Terbium 60-62 interferon gamma Homo sapiens 47-56 23626814-11 2013 The concentrations of sIL-2R, IL-6, TNF-alpha, IFN-gamma in COPD patients with TB were significantly higher than those in COPD patients without TB. Terbium 79-81 interferon gamma Homo sapiens 47-56 23582260-1 2013 Signal transducer and activator of transcription 1 (STAT1) is activated by tyrosine phosphorylation upon interferon-gamma (IFNgamma) stimulation, which results in the expression of genes with antiproliferative and immunomodulatory functions. Tyrosine 75-83 interferon gamma Homo sapiens 105-121 23613854-5 2013 RCC cells display basally-elevated NF-kappaB activity, and inhibiting NF-kappaB in these cells, for example by using the small-molecule proteasome blocker bortezomib, sensitizes them to RIP1-dependent necrotic death following exposure to IFN-gamma. Bortezomib 155-165 interferon gamma Homo sapiens 238-247 23613854-9 2013 Importantly, the IFN-gamma immunocytokines function as well as native IFN-gamma in inducing RIP1-dependent necrosis in RCC cells, when deployed in the presence of bortezomib. Bortezomib 163-173 interferon gamma Homo sapiens 17-26 23613965-0 2013 Lipoxin A4 and 15-epi-lipoxin A4 protect against experimental cerebral malaria by inhibiting IL-12/IFN-gamma in the brain. lipoxin A4 0-10 interferon gamma Homo sapiens 99-108 23613965-0 2013 Lipoxin A4 and 15-epi-lipoxin A4 protect against experimental cerebral malaria by inhibiting IL-12/IFN-gamma in the brain. lipoxin A4 15-32 interferon gamma Homo sapiens 99-108 23613965-9 2013 Moreover, in vivo administration of lipoxin to 5-LO-deficient hosts prevented early mortality and reduced the accumulation of CD8(+)IFN-gamma (+) cells in the brain. Lipoxins 36-43 interferon gamma Homo sapiens 132-141 23313323-9 2013 Infection with SU1-bel induced an enhanced adaptive immune response with greater interferon (IFN)-gamma responses and an earlier PRRSV-specific antibody response. su1-bel 15-22 interferon gamma Homo sapiens 81-103 23582260-1 2013 Signal transducer and activator of transcription 1 (STAT1) is activated by tyrosine phosphorylation upon interferon-gamma (IFNgamma) stimulation, which results in the expression of genes with antiproliferative and immunomodulatory functions. Tyrosine 75-83 interferon gamma Homo sapiens 123-131 23436577-1 2013 Beta2-adrenergic receptor (B2AR) signaling is known to impair Th1-cell differentiation and function in a cAMP-dependent way, leading to inhibition of cell proliferation and decreased production of IL-2 and IFN-gamma. Cyclic AMP 105-109 interferon gamma Homo sapiens 206-215 23429006-6 2013 The IFN-gamma/IL-5 ratio of mitogen-induced cytokines was also lower in IR- compared to TC- or TV-vaccinated children. Technetium 88-90 interferon gamma Homo sapiens 4-13 23526099-0 2013 Enhanced generation of reactive oxygen species by interferon-gamma may have contributed to successful treatment of invasive pulmonary aspergillosis in a patient with chronic granulomatous disease. Reactive Oxygen Species 23-46 interferon gamma Homo sapiens 50-66 23526099-4 2013 In this case, augmentation of ROS generation in the patient"s neutrophils was observed after in vivo IFN-gamma treatment, which may be attributable to the induction of a normal CYBB gene in the myeloid progenitor cells. Reactive Oxygen Species 30-33 interferon gamma Homo sapiens 101-110 23526099-6 2013 These results suggest that the in vivo use of IFN-gamma may augment ROS generation in CGD neutrophils, thus leading to the successful treatment of severe IPA. Reactive Oxygen Species 68-71 interferon gamma Homo sapiens 46-55 22994697-0 2013 Relationship between levels of IFNgamma, TNFalpha, and TGFbeta and pruritus in sulfur mustard-exposed veterans. Mustard Gas 79-93 interferon gamma Homo sapiens 31-39 23457382-8 2013 ATRA significantly increased intracellular IFN-gamma in cases but not in controls. Tretinoin 0-4 interferon gamma Homo sapiens 43-52 23333413-4 2013 VAL-44 induced antigen-specific IFN-gamma-producing CD4+ T cells and CD8+ T cells. val-44 0-6 interferon gamma Homo sapiens 32-41 23333413-5 2013 VAL-44 elicited a Th1-biased immune response with secretion of high amounts of IFN-gamma and IL-2, compared with VL-20. val-44 0-6 interferon gamma Homo sapiens 79-88 23816766-7 2013 The level of interferon (IFN)-gamma released from Th1 was lower in the magnesium group at time point 3 (p = 0.009). Magnesium 71-80 interferon gamma Homo sapiens 13-35 23108099-7 2013 In intestinal biopsies from CD patients challenged in vitro with gliadins (n=10), we demonstrated further that K-gliadins dramatically reduced the levels of antigen-specific IFNgamma mRNA in all specimens responsive to native gliadins (four of 10; P<0.05). k-gliadins 111-121 interferon gamma Homo sapiens 174-182 23816766-10 2013 The IFN-gamma /IL-6, IFN-gamma /IL-4 and IFN-gamma /IL-10 ratios were lower in the magnesium group after allograft reperfusion. Magnesium 83-92 interferon gamma Homo sapiens 4-13 23816766-10 2013 The IFN-gamma /IL-6, IFN-gamma /IL-4 and IFN-gamma /IL-10 ratios were lower in the magnesium group after allograft reperfusion. Magnesium 83-92 interferon gamma Homo sapiens 21-30 23816766-10 2013 The IFN-gamma /IL-6, IFN-gamma /IL-4 and IFN-gamma /IL-10 ratios were lower in the magnesium group after allograft reperfusion. Magnesium 83-92 interferon gamma Homo sapiens 21-30 23449998-5 2013 The IFN-gamma-induced macrophage vitamin D-dependent antimicrobial peptide response was inhibited by IFN-beta and by IL-10, suggesting that the differential production of IFNs contributes to protection versus pathogenesis in some human bacterial infections. Vitamin D 33-42 interferon gamma Homo sapiens 4-13 23190888-7 2013 Significant correlations were found between SE induced upregulation of mRNA expression for ifn-gamma, il-17, il-22, ip-10, and serum level of antistreptolysin O in psoriatic patients. Selenium 44-46 interferon gamma Homo sapiens 91-100 23220107-14 2013 Nanogel-delivered ova with mannose surface decoration was superior to free ova for inducing interferon-gamma production by T-lymphocytes. Mannose 27-34 interferon gamma Homo sapiens 92-108 23313612-0 2013 The decrease of paclitaxel efflux by pretreatment of interferon-gamma and tumor necrosis factor-alpha after intracerebral microinjection. Paclitaxel 16-26 interferon gamma Homo sapiens 53-101 23461851-5 2013 It was further confirmed that ATP was released from HaCaT cells stimulated with IFN-gamma. Adenosine Triphosphate 30-33 interferon gamma Homo sapiens 80-89 23241529-10 2013 Blocking ULBP3 and MICA/B reversed the effects of O3-exposed NECs on IFN-gamma production in NK cells. mica 19-23 interferon gamma Homo sapiens 69-78 23313612-7 2013 Furthermore, TNF-alpha and IFN-gamma induced significant decrease of paclitaxel efflux 1 and 24h pre-treatment. Paclitaxel 69-79 interferon gamma Homo sapiens 27-36 22935083-4 2013 Compared with placebo, fenofibrate reduced lymphocyte release of interleukin-2, interferon-gamma and tumour necrosis factor-alpha, which was accompanied by a reduction in plasma C-reactive protein levels. Fenofibrate 23-34 interferon gamma Homo sapiens 80-129 23331973-5 2013 In secondary mixed lymphocyte cultures, CsA dramatically decreased donor-specific IFN-gamma production, enhanced IL-17 production and did not affect IL-13. Cyclosporine 40-43 interferon gamma Homo sapiens 82-91 23106791-7 2013 The sensitivity of combined measurement of drug-specific IFN-gamma and IL-4 cytokines during acute DHR was better than LPA (82% vs. 50%), but all assays were less sensitive during the recovery phase. dhr 99-102 interferon gamma Homo sapiens 57-66 23422488-4 2013 The percentage of both IFN-gamma- and IL-17-producing Th17/Th1-like cells was significantly higher in the pSS, as compared to the control group, whereas that of Th2 cells was lower. pss 106-109 interferon gamma Homo sapiens 23-32 23502334-8 2013 Furthermore, a significant decrease in the level of IL-4 and an increase in the level of IFN-gamma were noticed in the intraperitoneally injected Sclareol group (p<0.05). sclareol 146-154 interferon gamma Homo sapiens 89-98 23359497-0 2013 Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma+CD4+ regulatory T cells to control transplant arteriosclerosis. Dinoprostone 0-16 interferon gamma Homo sapiens 65-74 23359497-10 2013 These findings indicate that PGE(2) helps MSC-induced IL-10(+)IFN-gamma(+)CD4(+) T(R)1-like cells inhibit TA. Prostaglandins E 29-32 interferon gamma Homo sapiens 62-71 23164921-0 2013 Catalpol inhibits LPS plus IFN-gamma-induced inflammatory response in astrocytes primary cultures. catalpol 0-8 interferon gamma Homo sapiens 27-36 26785784-12 2013 A similar study using the interferon-gamma release assay, which is more specific, would be more helpful to obtain more reliable epidemiological data on patient outcomes and to determine the appropriateness of the use of chemoprophylaxis with isoniazid. Isoniazid 242-251 interferon gamma Homo sapiens 26-42 23683418-14 2013 CONCLUSION: (1)Human MSCs constitutively expressed immunosuppressive concentrations of PGE2, HGF and TGF-beta1, and their expressions were significantly up-regulated by IFN-gamma. Dinoprostone 87-91 interferon gamma Homo sapiens 169-178 23683418-15 2013 (2)IFN-gamma-induced expression of IDO on MSCs involved in tryptophan catabolism. Tryptophan 59-69 interferon gamma Homo sapiens 3-12 23751529-7 2013 The level of IFN-gamma was (52.98 +- 17.56) ng/L in gingival crevicular fluid of RSA group and (25.25 +- 7.93) ng/L in control group (P < 0.01). rabbit sperm membrane autoantigen 81-84 interferon gamma Homo sapiens 13-22 23751529-9 2013 The content of IFN-gamma was (27.79 +- 3.59) ng/L in peripheral blood of RSA group and (18.39 +- 2.65) ng/L in control group (P < 0.05). rabbit sperm membrane autoantigen 73-76 interferon gamma Homo sapiens 15-24 23243276-2 2013 Recently, several studies have shown that anti-IFN-gamma autoantibodies may play an important role in the pathogenicity of dNTM infections. dntm 123-127 interferon gamma Homo sapiens 47-56 23243276-9 2013 In conclusion, our data suggest that anti-IFN-gamma autoantibodies may play a critical role in the pathogenesis of dNTM infections and reactivation of latent varicella-zoster virus infection and are associated with HLA-DRB1*16:02 and HLA-DQB1*05:02. dntm 115-119 interferon gamma Homo sapiens 42-51 23266381-8 2013 Interestingly, DPC-333 was found to up-regulate mRNA expression of caspase-1 in hPBMC in a dose dependent fashion and selective caspase-1 inhibitor completely restored DPC-333 induced IL-1beta and IFN-gamma. BMS561392 15-22 interferon gamma Homo sapiens 197-206 23266381-9 2013 Furthermore, selective IL-1beta receptor antagonist (anakinra) prevented DPC-333 induced IFN-gamma. BMS561392 73-80 interferon gamma Homo sapiens 89-98 23274966-9 2013 In a comparison of the relative potency of each drug at different dosing ranges, tacrolimus had the strongest Th1 inhibitory effect (median inhibition of interferon-gamma at 97.5%; P=0.004-0.008) followed by sirolimus (median inhibition at 82.4%). Tacrolimus 81-91 interferon gamma Homo sapiens 154-170 23274966-10 2013 The remaining agents (MPA, belatacept, and tofacitinib) had less apparent dose-dependent effects on interferon-gamma (belatacept median inhibition at 21.5%; P=0.004 vs. tacrolimus). tofacitinib 43-54 interferon gamma Homo sapiens 100-116 24049660-11 2013 The significantly increased postchallenge concentrations of IL-2, IL-8, IL-12p70, IL-13, IL-18, IFN- gamma , TNF- alpha , and TGF- beta were released by peripheral blood cells after stimulation with PMA, as compared with both their prechallenge concentrations and with the PBS control values. Tetradecanoylphorbol Acetate 199-202 interferon gamma Homo sapiens 96-106 23255592-3 2013 In inflamed HLMVEC (pretreated with interleukin-1beta and interferon-gamma), we found enhanced binding of eNOS to calcium-calmodulin at basal Ca(2+) levels, thereby increasing its basal activity that was dependent on extracellular l-Arg. Arginine 231-236 interferon gamma Homo sapiens 58-74 23371457-10 2013 Both Jitongning Capsule and sulfasalazine treatment induced significant decrease in the proportion of CD4(+)T cell and CD8(+)T cell expressing TNF-alpha and IFN-gamma at 12-month of treatment compared with baseline values (P<0.05). jitongning capsule 5-23 interferon gamma Homo sapiens 157-166 23296709-2 2013 We recently demonstrated that dual oxidase (Duox)2, an NADPH oxidase essential for reactive oxygen species-related, gastrointestinal host defense, is regulated by IFN-gamma-mediated Stat1 binding to the Duox2 promoter in pancreatic tumor lines. Reactive Oxygen Species 83-106 interferon gamma Homo sapiens 163-172 23296709-7 2013 Sustained extracellular accumulation of H(2)O(2) generated by exposure to both LPS and IFN-gamma was responsible for an ~50% decrease in BxPC-3 cell proliferation associated with a G(1) cell cycle block, apoptosis, and DNA damage. Hydrogen Peroxide 40-48 interferon gamma Homo sapiens 87-96 23374147-6 2013 Moreover, TIVA-TCI patients also showed a higher increase in IFN-gamma, whereas in BAL patients Tregs were reduced by approximately 30% during surgery. tiva-tci 10-18 interferon gamma Homo sapiens 61-70 23286943-6 2013 Patients treated with rosiglitazone demonstrated significant (P < 0 03) down-regulation of islet-specific T cell responses, although no change in response to tetanus, a significant decrease (P < 0 05) in IFN-gamma production and significantly (P < 0 001) increased levels of adiponectin compared to glyburide-treated patients. Rosiglitazone 22-35 interferon gamma Homo sapiens 210-219 23371457-10 2013 Both Jitongning Capsule and sulfasalazine treatment induced significant decrease in the proportion of CD4(+)T cell and CD8(+)T cell expressing TNF-alpha and IFN-gamma at 12-month of treatment compared with baseline values (P<0.05). Sulfasalazine 28-41 interferon gamma Homo sapiens 157-166 22784440-0 2013 Maturation of human iDCs by IL-18 plus PGE2, but not by each stimulus alone, induced migration toward CCL21 and the secretion of IL-12 and IFN-gamma. Dinoprostone 39-43 interferon gamma Homo sapiens 139-148 22784440-4 2013 When administered simultaneously to 1x10(6)iDCs/ml, IL-18+PGE2 induced the secretion of 131.4+-6.7 pg IL-12/ml and 355+-87 pg IFN-gamma/ml but there was no detectable IL-10 secretion. Dinoprostone 58-62 interferon gamma Homo sapiens 126-135 23017670-4 2013 Sixteen hours PMA/Ionomycin stimulation induced iTreg subsets with the phenotype CD4(+)CD25(+)Foxp3(+), CD4(+)IFNgamma(+)Foxp3(+) and CD4(+)CD25(+)IFNgamma(+) co-expressing CD95, CD152, CD178, CD279, Granzyme A, Granzyme B, Perforin, IL-10, and TGFbeta(1). Ionomycin 18-27 interferon gamma Homo sapiens 110-118 23266494-0 2013 Depletion of IL-22 during culture enhanced antigen-driven IFN-gamma production by CD4(+)T cells from patients with active TB. Terbium 122-124 interferon gamma Homo sapiens 58-67 23017670-4 2013 Sixteen hours PMA/Ionomycin stimulation induced iTreg subsets with the phenotype CD4(+)CD25(+)Foxp3(+), CD4(+)IFNgamma(+)Foxp3(+) and CD4(+)CD25(+)IFNgamma(+) co-expressing CD95, CD152, CD178, CD279, Granzyme A, Granzyme B, Perforin, IL-10, and TGFbeta(1). Ionomycin 18-27 interferon gamma Homo sapiens 147-155 22539447-3 2013 In addition, the correlation of plasma neopterin with interferon-gamma (IFN-gamma) and interleukin-6 (IL-6) was also examined. Neopterin 39-48 interferon gamma Homo sapiens 54-70 22539447-3 2013 In addition, the correlation of plasma neopterin with interferon-gamma (IFN-gamma) and interleukin-6 (IL-6) was also examined. Neopterin 39-48 interferon gamma Homo sapiens 72-81 22539447-11 2013 Significant associations between neopterin and IFN-gamma (r = 0.41, p < 0.0001) and IL-6 (r = 0.35, p = 0.0006) levels were found. Neopterin 33-42 interferon gamma Homo sapiens 47-56 23190183-0 2013 Interferon-gamma with peginterferon alpha-2a and ribavirin in nonresponder patients with chronic hepatitis C (ANRS HC16 GAMMATRI). Ribavirin 49-58 interferon gamma Homo sapiens 0-16 22710762-7 2013 Exposure to thalidomide (100 microg/ml) reduced the intracytoplasmic pro-inflammatory cytokine production of neonatal monocytes and the IFN-gamma production of neonatal lymphocytes. Thalidomide 12-23 interferon gamma Homo sapiens 136-145 22710762-8 2013 In supernatants, the addition of thalidomide resulted in reduction of TNF-alpha, IL-6, IL-10 and, by trend, IFN-gamma. Thalidomide 33-44 interferon gamma Homo sapiens 108-117 22704783-6 2013 We further examined the effects of lycopene stimulation on cytokine levels in MNC and showed that, as compared to the control, lycopene (10 mumol/L) significantly (P<.001) up-regulated interleukin (IL)-12 by 163% and interferon (IFN)-gamma by 531%. Lycopene 127-135 interferon gamma Homo sapiens 220-242 23172685-5 2013 Interestingly, Gag-specific DN T-cell responses were found in 3/13 (23%) HIV-exposed seronegative individuals (Group A), involving both DN/alphabeta(+) and DN/gammadelta(+) T-cells through MIP1beta and IFNgamma production. Glycosaminoglycans 15-18 interferon gamma Homo sapiens 202-210 22704783-7 2013 Furthermore, pre-treatment of HUVECs with dexamethasone, an IL-12 inhibitor, blocked the anti-angiogenic effects of LP-MNC-CM in parallel with inhibition of IL-12 and IFN-gamma induction in MNC. Dexamethasone 42-55 interferon gamma Homo sapiens 167-176 23298196-4 2013 Consistent with these results, the combination of CIM and LMS produced the highest level of IL-2 and IFN-gamma in antigen-specific CD4(+) T cells, whereas the combination of CIM and LMS did not further increase IL-4 production. Cimetidine 50-53 interferon gamma Homo sapiens 101-110 22704783-8 2013 These results demonstrate that lycopene has a potent anti-angiogenic effect and that these effect may be associated with its up-regulation of IL-12 and IFN-gamma. Lycopene 31-39 interferon gamma Homo sapiens 152-161 23710915-4 2013 In addition, the expression of IFN-gamma, IL-10 and TGF-beta1 mRNA in lymphocytes of lymph nodes draining the tumors was detected by in situ hybridization with the corresponding specific oligo nucleaic acid probes. oligo nucleaic acid 187-206 interferon gamma Homo sapiens 31-40 24715949-6 2013 Interferon gamma (IFN-gamma) and tumour necrosis factor alpha (TNF-alpha) play crucial roles in the initial activation of HIDEMs and importantly indoleamine 2,3 dioxygenase (IDO) and prostaglandin E2 (PGE-2) were identified as key mechanisms involved in HIDEM suppression of T cell proliferation. Dinoprostone 183-199 interferon gamma Homo sapiens 0-16 23372571-14 2013 We speculate that the polysaccharide fragments of LPS molecule may take part in LPS-induced IFN-gamma production by NK cells. Polysaccharides 22-36 interferon gamma Homo sapiens 92-101 24715949-6 2013 Interferon gamma (IFN-gamma) and tumour necrosis factor alpha (TNF-alpha) play crucial roles in the initial activation of HIDEMs and importantly indoleamine 2,3 dioxygenase (IDO) and prostaglandin E2 (PGE-2) were identified as key mechanisms involved in HIDEM suppression of T cell proliferation. Dinoprostone 183-199 interferon gamma Homo sapiens 18-27 24715949-6 2013 Interferon gamma (IFN-gamma) and tumour necrosis factor alpha (TNF-alpha) play crucial roles in the initial activation of HIDEMs and importantly indoleamine 2,3 dioxygenase (IDO) and prostaglandin E2 (PGE-2) were identified as key mechanisms involved in HIDEM suppression of T cell proliferation. Dinoprostone 201-206 interferon gamma Homo sapiens 0-16 24715949-6 2013 Interferon gamma (IFN-gamma) and tumour necrosis factor alpha (TNF-alpha) play crucial roles in the initial activation of HIDEMs and importantly indoleamine 2,3 dioxygenase (IDO) and prostaglandin E2 (PGE-2) were identified as key mechanisms involved in HIDEM suppression of T cell proliferation. Dinoprostone 201-206 interferon gamma Homo sapiens 18-27 23164666-2 2013 Differentiation of Th1 and Th17 subsets is mainly regulated by interleukins (ILs) secreted from dendritic cells (DCs) and the ability of inorganic arsenic to impair interferon-gamma and IL-17 secretion by interfering with the physiology of DCs is unknown. Arsenic 147-154 interferon gamma Homo sapiens 165-181 23331510-2 2013 BACKGROUND: Vitamin D enhances host protective immune responses to Mycobacterium tuberculosis by suppressing Interferon-gamma (IFN-g) and reducing disease associated inflammation in the host. Vitamin D 12-21 interferon gamma Homo sapiens 127-132 23331510-9 2013 Vitamin D supplementation led to significant increase in MTBs-induced IFN-g secretion in patients with baseline "Deficient" 25-hydroxyvitamin D serum levels (p 0.021). Vitamin D 0-9 interferon gamma Homo sapiens 70-75 23331510-9 2013 Vitamin D supplementation led to significant increase in MTBs-induced IFN-g secretion in patients with baseline "Deficient" 25-hydroxyvitamin D serum levels (p 0.021). mtbs 57-61 interferon gamma Homo sapiens 70-75 23331510-9 2013 Vitamin D supplementation led to significant increase in MTBs-induced IFN-g secretion in patients with baseline "Deficient" 25-hydroxyvitamin D serum levels (p 0.021). 25-hydroxyvitamin D 124-143 interferon gamma Homo sapiens 70-75 23144328-13 2013 IFN-gamma and IL-10 levels were significantly suppressed in stimulated whole blood of patients with pNTM. pntm 100-104 interferon gamma Homo sapiens 0-9 23275297-3 2013 In this study, whole-transcriptome sequencing of normal, chronic phase, and serially transplantable blast crisis chronic myeloid leukemia (CML) progenitors revealed increased IFN-gamma pathway gene expression in concert with BCR-ABL amplification, enhanced expression of the IFN-responsive ADAR1 p150 isoform, and a propensity for increased adenosine-to-inosine RNA editing during CML progression. Adenosine 341-350 interferon gamma Homo sapiens 175-184 23275297-3 2013 In this study, whole-transcriptome sequencing of normal, chronic phase, and serially transplantable blast crisis chronic myeloid leukemia (CML) progenitors revealed increased IFN-gamma pathway gene expression in concert with BCR-ABL amplification, enhanced expression of the IFN-responsive ADAR1 p150 isoform, and a propensity for increased adenosine-to-inosine RNA editing during CML progression. Inosine 354-361 interferon gamma Homo sapiens 175-184 23164666-7 2013 Finally, differentiation of monocytes with non-cytotoxic concentrations of As(III) subsequently reduces the ability of activated DCs to stimulate the release of interferon-gamma and IL-17 from Th cells. as(iii) 75-82 interferon gamma Homo sapiens 161-177 23149273-7 2013 The flow cytometric studies showed that mycolic acid induced the production of pro-inflammatory cytokines, TNF-alpha and IFN-gamma by CD3+ T cells. Mycolic Acids 40-52 interferon gamma Homo sapiens 121-130 22989785-5 2013 We found that poly (I:C) could induce CXCL10 in NCI-H295R adrenocortical carcinoma cells, either alone or synergistically along with cytokines interferon-gamma and tumor necrosis factor-alpha. Poly I-C 14-24 interferon gamma Homo sapiens 143-191 22722755-3 2013 A total of 25 patients with a history of cephalosporin-induced MPE were skin tested and the frequencies of cephalosporin-specific interferon-gamma-, interleukin-5-, and interleukin-10-releasing cells/10(6) peripheral blood mononuclear cells were measured after stimulating with the culprit drug, compared with 20 non-allergic controls. Cephalosporins 107-120 interferon gamma Homo sapiens 130-146 22722755-5 2013 The study showed that the combination of interferon-gamma and interleukin-5 enzyme-linked immunospot assays was more sensitive than skin testing to diagnose cephalosporin allergy (40% vs. 8%, p = 0.008) and sensitivity increased to 57.1% when the test was performed within 2 years of the drug reaction. Cephalosporins 157-170 interferon gamma Homo sapiens 41-57 24189419-0 2013 Pheophytin a and chlorophyll a identified from environmentally friendly cultivation of green pepper enhance interleukin-2 and interferon-gamma in Peyer"s patches ex vivo. pheophytin a 0-12 interferon gamma Homo sapiens 126-142 24189419-0 2013 Pheophytin a and chlorophyll a identified from environmentally friendly cultivation of green pepper enhance interleukin-2 and interferon-gamma in Peyer"s patches ex vivo. chlorophyll a 17-30 interferon gamma Homo sapiens 126-142 24189419-6 2013 Intake of pheophytin a and chlorophyll a significantly increased IL-2 and IFN-gamma production, and the percentage of IL-2- and IFN-gamma-producing CD4+ T-cells in PP. pheophytin a 10-22 interferon gamma Homo sapiens 74-83 24189419-6 2013 Intake of pheophytin a and chlorophyll a significantly increased IL-2 and IFN-gamma production, and the percentage of IL-2- and IFN-gamma-producing CD4+ T-cells in PP. chlorophyll a 27-40 interferon gamma Homo sapiens 74-83 23936793-3 2013 Flow cytometry showed that the number of CD4(+) and CD8(+) cells and the level of IFN- gamma decreased significantly in the groups treated with cyclosporin A. Cyclosporine 144-157 interferon gamma Homo sapiens 82-92 24024215-5 2013 It was reported previously that interferon gamma (IFN-gamma) and nitric oxide synthase 2 (NOS2) are expressed on alveolar macrophages from TB patients and are responsible for bacilli control; thus, we aimed this study at genotyping single nucleotide polymorphisms IFNG+874T/A SNP and NOS2A-954G/C SNP to estimate their role on TB susceptibility and determine whether these polymorphisms influence serum nitrite and NOx(-) production. Nitrites 403-410 interferon gamma Homo sapiens 32-59 24024215-5 2013 It was reported previously that interferon gamma (IFN-gamma) and nitric oxide synthase 2 (NOS2) are expressed on alveolar macrophages from TB patients and are responsible for bacilli control; thus, we aimed this study at genotyping single nucleotide polymorphisms IFNG+874T/A SNP and NOS2A-954G/C SNP to estimate their role on TB susceptibility and determine whether these polymorphisms influence serum nitrite and NOx(-) production. nicotine 1-N-oxide 415-418 interferon gamma Homo sapiens 32-59 24078927-0 2013 Synthesis of a novel thiazolidinedione and evaluation of its modulatory effect on IFN- gamma , IL-6, IL-17A, and IL-22 production in PBMCs from rheumatoid arthritis patients. 2,4-thiazolidinedione 21-38 interferon gamma Homo sapiens 82-92 23160925-0 2013 Heparins modulate the IFN-gamma-induced production of chemokines in human breast cancer cells. Heparin 0-8 interferon gamma Homo sapiens 22-31 24236291-7 2013 After K562 target cell stimulation, PBMC produced profound proinflammatory and immunoregulatory cytokines/chemokines including IL-2, IL-8, IL-10, MIP-1 alpha beta , IFN- gamma , and TNF- alpha , and cytokine/chemokine secretion was related to flowcytometry-based NK cytotoxicity. PBMC 36-40 interferon gamma Homo sapiens 165-175 24936371-0 2013 Oral Administration of EC-12 Increases the Baseline Gene Expression of Antiviral Cytokine Genes, IFN-gamma and TNF-alpha, in Splenocytes and Mesenteric Lymph Node Cells of Weaning Piglets. ec-12 23-28 interferon gamma Homo sapiens 97-106 22733396-4 2013 We demonstrate that exposure to lenalidomide in the context of T-cell expansion with direct ligation of CD3/CD28 complex results in polarization toward a Th1 phenotype characterized by increased IFN-gamma, but not IL-10 expression. Lenalidomide 32-44 interferon gamma Homo sapiens 195-204 23781253-6 2013 Therefore, DXM abrogated the ability of LPS-stimulated DCs to induce Ag-specific T-cell activation, as determined by their decreased proliferation and IFN- gamma secretion in mixed leukocyte cultures. Dextromethorphan 11-14 interferon gamma Homo sapiens 151-161 24489577-8 2013 Compared to spontaneous release, superoxide release was stimulated by IFN- gamma and TGF- beta in normoglycemic and diabetic groups. Superoxides 33-43 interferon gamma Homo sapiens 70-80 23160925-8 2013 UFH dose dependently inhibited the effect of IFN-gamma on the secretion and expression of CXCL9 and CXCL10. Heparin 0-3 interferon gamma Homo sapiens 45-54 23160925-9 2013 LMWHs and heparin-related compounds differentially modulated IFN-gamma-effects-the results depended on their molecular size and charge, but were independent of their anticoagulatory properties. Heparin 10-17 interferon gamma Homo sapiens 61-70 23160925-10 2013 As a reason for these heparin effects, we could show that the IFN-gamma-induced phosphorylation of STAT1 was modulated by heparins, caused by an interaction with the cellular binding of IFN-gamma. Heparin 22-29 interferon gamma Homo sapiens 62-71 23160925-10 2013 As a reason for these heparin effects, we could show that the IFN-gamma-induced phosphorylation of STAT1 was modulated by heparins, caused by an interaction with the cellular binding of IFN-gamma. Heparin 22-29 interferon gamma Homo sapiens 186-195 23160925-10 2013 As a reason for these heparin effects, we could show that the IFN-gamma-induced phosphorylation of STAT1 was modulated by heparins, caused by an interaction with the cellular binding of IFN-gamma. Heparin 122-130 interferon gamma Homo sapiens 62-71 23160925-10 2013 As a reason for these heparin effects, we could show that the IFN-gamma-induced phosphorylation of STAT1 was modulated by heparins, caused by an interaction with the cellular binding of IFN-gamma. Heparin 122-130 interferon gamma Homo sapiens 186-195 23103122-5 2013 Therefore, the aim of the present study was to investigate calcitriol effects upon TNF-alpha, IFN-gamma, IL-6 and IL-1beta in cultured placental cells from preeclamptic women by using qPCR and ELISA. Calcitriol 59-69 interferon gamma Homo sapiens 94-103 23762128-3 2013 Results showed that shikonin dose dependently suppressed T-cell proliferation, IL-2 and IFN- gamma secretion, CD69 and CD25 expression, as well as cell cycle arrest activated by costimulation of PMA/ionomycin or OKT-3/CD28 monoclonal antibodies. shikonin 20-28 interferon gamma Homo sapiens 88-98 22790915-9 2013 In addition, DMF inhibited IFN-gamma-induced CXCL10 secretion. Dimethyl Fumarate 13-16 interferon gamma Homo sapiens 27-36 23063592-5 2013 In vivo, the results showed that CPs could not only inhibit the growth of the tumor, but also enhance the spleen index, as well as the level of IL-2, IFN-gamma and TNF-alpha. cps 33-36 interferon gamma Homo sapiens 150-159 24083022-7 2013 TNF-alpha potentiates interferon-gamma-induced transcriptional activation of indoleamine 2,3-dioxygenase, the rate-limiting enzyme of tryptophan- (TRP-) kynurenine (KYN) metabolism. indolamine 77-88 interferon gamma Homo sapiens 22-38 23276926-4 2013 The effect of EGCG was attributable to its selective inhibition of interferon-gamma and interleukin-17 production in CD4+ T cells, mediated via alteration of the STAT pathway and the transcription factors T-bet and retinoid-related orphan receptor (ROR) gammat/ROR alpha. epigallocatechin gallate 14-18 interferon gamma Homo sapiens 67-83 23174508-7 2013 The percentage of IFN-gamma producing gammadelta T cells treated with Phloretin was significantly higher than control group. Phloretin 70-79 interferon gamma Homo sapiens 18-27 23174508-8 2013 CONCLUSION: Phloretin can enhance the killing effect of gammadelta T cells on SW-1116 cells; the mechanism may be that Phloretin could proliferate the gammadelta T cell growth, increase the expression of PFP and GraB, activate the Wnt signaling pathway, and produce higher level of IFN-gamma. Phloretin 12-21 interferon gamma Homo sapiens 282-291 23174508-8 2013 CONCLUSION: Phloretin can enhance the killing effect of gammadelta T cells on SW-1116 cells; the mechanism may be that Phloretin could proliferate the gammadelta T cell growth, increase the expression of PFP and GraB, activate the Wnt signaling pathway, and produce higher level of IFN-gamma. Phloretin 119-128 interferon gamma Homo sapiens 282-291 24083022-7 2013 TNF-alpha potentiates interferon-gamma-induced transcriptional activation of indoleamine 2,3-dioxygenase, the rate-limiting enzyme of tryptophan- (TRP-) kynurenine (KYN) metabolism. Tryptophan 134-144 interferon gamma Homo sapiens 22-38 24083022-7 2013 TNF-alpha potentiates interferon-gamma-induced transcriptional activation of indoleamine 2,3-dioxygenase, the rate-limiting enzyme of tryptophan- (TRP-) kynurenine (KYN) metabolism. Tryptophan 147-150 interferon gamma Homo sapiens 22-38 24083022-7 2013 TNF-alpha potentiates interferon-gamma-induced transcriptional activation of indoleamine 2,3-dioxygenase, the rate-limiting enzyme of tryptophan- (TRP-) kynurenine (KYN) metabolism. Kynurenine 153-163 interferon gamma Homo sapiens 22-38 24083022-7 2013 TNF-alpha potentiates interferon-gamma-induced transcriptional activation of indoleamine 2,3-dioxygenase, the rate-limiting enzyme of tryptophan- (TRP-) kynurenine (KYN) metabolism. Kynurenine 165-168 interferon gamma Homo sapiens 22-38 24159421-4 2013 At concentrations that inhibited anti-CD3/28-stimulated T-cell proliferation (P < 0.01), simvastatin significantly decreased intracellular CD4(+) T-cell expression of IFN-gamma (P < 0.01) to levels similar to those induced by conventional immunosuppressives. Simvastatin 92-103 interferon gamma Homo sapiens 170-179 24159421-5 2013 Atorvastatin and lovastatin also decreased IFN-gamma expression, although to a lesser degree (P < 0.05). Atorvastatin 0-12 interferon gamma Homo sapiens 43-52 24159421-5 2013 Atorvastatin and lovastatin also decreased IFN-gamma expression, although to a lesser degree (P < 0.05). Lovastatin 17-27 interferon gamma Homo sapiens 43-52 23001491-6 2013 IFN-gamma pretreatment resulted in over-proportionally enhanced lysis of SDC. S-[2-(Aminosulfonyl)ethyl]-D-Cysteine 73-76 interferon gamma Homo sapiens 0-9 23717040-6 2013 In vivo, nPOPG suppressed inflammatory cell infiltration into the lung, as well as IFN-gamma production in response to RSV challenge. Respiratory Syncytial Virus Vaccines 119-122 interferon gamma Homo sapiens 83-92 22990666-7 2013 Stimulation of the T(EM) cells in HCL volunteers induced a significantly higher IFN-gamma production (P=0.04) with higher number of intracellular IFN-gamma positive cells (P=0.032) than the same cells from controls. Hydrochloric Acid 34-37 interferon gamma Homo sapiens 80-89 23341700-5 2013 Treatment with gemcitabine enhanced the production of IFN-gamma and decreased the number of regulatory T cells. gemcitabine 15-26 interferon gamma Homo sapiens 54-63 23341700-6 2013 gemcitabine treatment increased IFN-gamma production among CD4 T cells but not among CD8 T cells. gemcitabine 0-11 interferon gamma Homo sapiens 32-41 22990666-7 2013 Stimulation of the T(EM) cells in HCL volunteers induced a significantly higher IFN-gamma production (P=0.04) with higher number of intracellular IFN-gamma positive cells (P=0.032) than the same cells from controls. Hydrochloric Acid 34-37 interferon gamma Homo sapiens 146-155 23740679-2 2013 Neopterin is regarded as a biochemical marker of cell-mediated immunity, which is secreted by monocytes and macrophages, mainly in response to interferon-gamma. Neopterin 0-9 interferon gamma Homo sapiens 143-159 23964551-9 2013 The Cetavlon-precipitated mannans of fungi induced cytokine responses that were similar or superior to those induced by whole extracts, C albicans being the most potent inducer of IFN-gamma. Cetrimonium 4-12 interferon gamma Homo sapiens 180-189 23964551-9 2013 The Cetavlon-precipitated mannans of fungi induced cytokine responses that were similar or superior to those induced by whole extracts, C albicans being the most potent inducer of IFN-gamma. Mannans 26-33 interferon gamma Homo sapiens 180-189 23575689-2 2013 cAMP has long been believed to act as a suppressor of IFN-gamma production and Th1 cell-mediated immune inflammation. Cyclic AMP 0-4 interferon gamma Homo sapiens 54-63 23317804-11 2013 Abnormally low concentrations of sex hormones are associated with higher serum levels of TNF-alpha and IFN-gamma, which could suggest suppressive effect of estradiol and progesterone on pro-inflammatory cytokine secretion. Estradiol 157-166 interferon gamma Homo sapiens 104-113 23317804-11 2013 Abnormally low concentrations of sex hormones are associated with higher serum levels of TNF-alpha and IFN-gamma, which could suggest suppressive effect of estradiol and progesterone on pro-inflammatory cytokine secretion. Progesterone 171-183 interferon gamma Homo sapiens 104-113 23042548-6 2013 The results revealed that IDO was expressed in SGC-996 cells in a dose- and time-dependent manner when stimulated with IFN-gamma and SAHA down-regulated the expression of IDO induced by IFN-gamma in a dose-dependent manner. Vorinostat 157-161 interferon gamma Homo sapiens 222-231 23042548-7 2013 SAHA blocked the expression of IRF-1 induced by IFN-gamma and SAHA inhibited IFN-gamma-induced STAT1 phosphorylation and nuclear translocation. Vorinostat 0-4 interferon gamma Homo sapiens 60-69 23042548-7 2013 SAHA blocked the expression of IRF-1 induced by IFN-gamma and SAHA inhibited IFN-gamma-induced STAT1 phosphorylation and nuclear translocation. Vorinostat 0-4 interferon gamma Homo sapiens 89-98 23042548-7 2013 SAHA blocked the expression of IRF-1 induced by IFN-gamma and SAHA inhibited IFN-gamma-induced STAT1 phosphorylation and nuclear translocation. Vorinostat 74-78 interferon gamma Homo sapiens 89-98 23042548-8 2013 In addition, SAHA down-regulated IFN-gamma-induced activation of GAS and ISRE. Vorinostat 13-17 interferon gamma Homo sapiens 33-42 23129057-4 2013 The decrease in JNK-1 activity was followed by a marked decrease in the expression of interleukin (IL)-2 and a weak increase in interferon (IFN)-gamma in Jurkat cells treated with ATRA in a dose-dependent manner, suggesting a correlation between the expression of JNK-1 and the activity of the Tax protein. Tretinoin 216-220 interferon gamma Homo sapiens 152-174 23820300-5 2013 In human T-cell/CD14+ monocyte co-cultures, thymosin beta4-sulfoxide inhibits interferon-gamma, and increases monocyte dispersal and cell death, likely by stimulating superoxide production. beta4-sulfoxide 53-68 interferon gamma Homo sapiens 78-94 23950601-4 2013 RESULTS: Ninety-day simvastatin treatment reduced lymphocyte release of TNF-alpha, interleukin-2 and interferon-gamma, which was accompanied by a decrease in plasma C-reactive protein. Simvastatin 20-31 interferon gamma Homo sapiens 101-117 23744427-6 2013 RESULTS: Beyond improving glucose homeostasis, metformin reduced plasma C-reactive protein levels and lymphocyte release of tumor necrosis factor-alpha and interferon-gamma, as well as tended to reduce interleukin-2 release and plasma intercellular adhesion molecule-1. Metformin 47-56 interferon gamma Homo sapiens 156-172 23555696-10 2013 Similarly as seen with RNase 7, treatment of keratinocytes with IL-17A/IFN-gamma revealed also a synergistic induction of gene expression of the AMP human beta-defensin (hBD)-2 and -3 as well as the S100 protein psoriasin (S100A7) indicating that the combination of IL-17A/IFN-gamma is a potent inducer of various AMP classes in general. Adenosine Monophosphate 145-148 interferon gamma Homo sapiens 71-80 23555696-10 2013 Similarly as seen with RNase 7, treatment of keratinocytes with IL-17A/IFN-gamma revealed also a synergistic induction of gene expression of the AMP human beta-defensin (hBD)-2 and -3 as well as the S100 protein psoriasin (S100A7) indicating that the combination of IL-17A/IFN-gamma is a potent inducer of various AMP classes in general. Adenosine Monophosphate 145-148 interferon gamma Homo sapiens 64-80 23555696-10 2013 Similarly as seen with RNase 7, treatment of keratinocytes with IL-17A/IFN-gamma revealed also a synergistic induction of gene expression of the AMP human beta-defensin (hBD)-2 and -3 as well as the S100 protein psoriasin (S100A7) indicating that the combination of IL-17A/IFN-gamma is a potent inducer of various AMP classes in general. Adenosine Monophosphate 314-317 interferon gamma Homo sapiens 71-80 23555696-10 2013 Similarly as seen with RNase 7, treatment of keratinocytes with IL-17A/IFN-gamma revealed also a synergistic induction of gene expression of the AMP human beta-defensin (hBD)-2 and -3 as well as the S100 protein psoriasin (S100A7) indicating that the combination of IL-17A/IFN-gamma is a potent inducer of various AMP classes in general. Adenosine Monophosphate 314-317 interferon gamma Homo sapiens 64-80 23382974-7 2013 ATP plus atypical lipopolysaccharide from P. gingivalis (signaling through TLR2) was slightly superior to E. coli-derived LPS (TLR4 ligand) for inducing the high IL-23-secreting DC-like phenotype, but greatly inferior for inducing IL-12 p70 production when paired with IFN-gamma, a distinction reflected in activated DCs" ability to deviate lymphocytes toward Th1. Adenosine Triphosphate 0-3 interferon gamma Homo sapiens 269-278 23555904-7 2013 In comparison, addition of MPA and Cyclosporine A displayed reduced CD107a expression and IFN-gamma production following PMA/Ionomycin stimulation. Cyclosporine 35-49 interferon gamma Homo sapiens 90-99 23555904-7 2013 In comparison, addition of MPA and Cyclosporine A displayed reduced CD107a expression and IFN-gamma production following PMA/Ionomycin stimulation. Ionomycin 125-134 interferon gamma Homo sapiens 90-99 23437201-8 2013 To assess the immunregulatory action of Fenofibrate, we conducted in-vitro treatment of anti-CD3/CD28 stimulated human peripheral blood cells (PBMC), and, as predicted, Fenofibrate reduced IL17 and IFN-gamma gene expression in stimulated PMBC. Fenofibrate 169-180 interferon gamma Homo sapiens 198-207 23382842-0 2013 Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country. Terbium 60-62 interferon gamma Homo sapiens 0-16 23335969-10 2013 Both FadA and Td92 induced the production of IFNgamma and IL-10 but inhibited the secretion of IL-4 by PBMCs. fada 5-9 interferon gamma Homo sapiens 45-53 23601165-4 2013 Interferon-gamma is the most potent inducer of ROS-RNS formation in target cells like macrophages. ros 47-50 interferon gamma Homo sapiens 0-16 23742090-0 2013 Production, purification, and chemical stability of recombinant human interferon-gamma in low oxygen tension condition: a formulation approach. Oxygen 94-100 interferon gamma Homo sapiens 70-86 23601165-4 2013 Interferon-gamma is the most potent inducer of ROS-RNS formation in target cells like macrophages. Radon 51-54 interferon gamma Homo sapiens 0-16 23720855-5 2013 The data of studies of the effect of cycloferon on the elaboration of interferon-gamma that is able to activate a Th1 immune response, which promotes the shorter time of abacillation and decay cavity closure and positive X-ray changes, are given. 10-carboxymethyl-9-acridanone 37-47 interferon gamma Homo sapiens 70-86 22258456-0 2013 Interferon-gamma induced nitric oxide-mediated apoptosis of anemia of chronic disease in rheumatoid arthritis. Nitric Oxide 25-37 interferon gamma Homo sapiens 0-16 22258456-8 2013 In addition, IFN-gamma showed significantly increased nitric oxide production and iNOS mRNA expression, which was measured by Griess assay and real-time PCR, respectively. Nitric Oxide 54-66 interferon gamma Homo sapiens 13-22 22258456-10 2013 In conclusion, IFN-gamma could induce nitric oxide production-mediated apoptosis process, which might be involved in the pathogenesis of ACD in RA patients. Nitric Oxide 38-50 interferon gamma Homo sapiens 15-24 23596884-1 2013 OBJECTIVE: To examine the anti-inflammatory mechanism of total flavonoids of Glycyrrhizae Radix et Rhizoma (TFGR) and its ingredient on IFN-gamma and LPS-induced macrophage RAW264.7. Flavonoids 63-73 interferon gamma Homo sapiens 136-145 23143065-4 2013 A cyclic AMP analog that specifically activates Epac, 8-(4-methoxyphenylthio)-2"-O-methyladenosine-3",5"-cyclic monophosphate (OPTmecAMP), and overexpression of liver-specific Epac2 both inhibited interleukin 1beta/interferon gamma-induced iNOS expression and nitrite production. Cyclic AMP 2-12 interferon gamma Homo sapiens 215-231 23154639-6 2012 Stimulation with IFN-gamma, IL-4 or PGE(2) induced activation of STAT1, STAT6 and cAMP, respectively, in colonic cells, without any signs of concomitant STAT3 activation. Cyclic AMP 82-86 interferon gamma Homo sapiens 17-26 23107042-5 2012 Metformin, but not placebo, administered to simvastatin-treated IFG subjects reduced plasma levels of C-reactive protein, soluble intercellular adhesion molecule-1, as well as lymphocyte release of interleukin-2, interferon-gamma and tumor necrosis factor-alpha, which was accompanied by the improvement in insulin sensitivity and a reduction in free fatty acid levels. Metformin 0-9 interferon gamma Homo sapiens 213-261 23117092-0 2012 Verbascum xanthophoeniceum-derived phenylethanoid glycosides are potent inhibitors of inflammatory chemokines in dormant and interferon-gamma-stimulated human keratinocytes. phenylethanoid glycosides 35-60 interferon gamma Homo sapiens 125-141 23084344-3 2012 Toda buffalo peripheral blood mononuclear cells (PBMC) produced significantly higher levels of IFN gamma and/or TNF alpha mRNAs in response to peptidoglycan, poly I:C, lipopolysaccharide, imiquimod and CpG. Poly I 158-164 interferon gamma Homo sapiens 95-104 23084344-3 2012 Toda buffalo peripheral blood mononuclear cells (PBMC) produced significantly higher levels of IFN gamma and/or TNF alpha mRNAs in response to peptidoglycan, poly I:C, lipopolysaccharide, imiquimod and CpG. Carbon 52-53 interferon gamma Homo sapiens 95-104 23107042-5 2012 Metformin, but not placebo, administered to simvastatin-treated IFG subjects reduced plasma levels of C-reactive protein, soluble intercellular adhesion molecule-1, as well as lymphocyte release of interleukin-2, interferon-gamma and tumor necrosis factor-alpha, which was accompanied by the improvement in insulin sensitivity and a reduction in free fatty acid levels. Simvastatin 44-55 interferon gamma Homo sapiens 213-261 22951220-10 2012 The explants exhibited a significant increase of caspase-3 activity when the colonic epithelial cells were incubated with IFN-gamma followed by ATP as compared to control cells. Adenosine Triphosphate 144-147 interferon gamma Homo sapiens 122-131 22556318-0 2012 Monthly follow-ups of interferon-gamma release assays among health-care workers in contact with patients with TB. Terbium 110-112 interferon gamma Homo sapiens 22-38 22941914-10 2012 In muscle cells exposed to IFNgamma plus IL-1beta, IgG and/or prednisone down-regulated mRNA expression of IL-1beta 2.5-fold. Prednisone 62-72 interferon gamma Homo sapiens 27-35 23151460-8 2012 Concerns that PBMC methylation differences may be confounded by variations in blood cell composition were justified for CpG sites with large methylation differences across cell types, such as in the IFN-gamma gene promoter. PBMC 14-18 interferon gamma Homo sapiens 199-208 23399839-6 2012 L-Arg depletion reduced the expression of NK-92 activating receptors, NKp46 and NKp30, the expression of NK zeta chain and the NK-92 intracellular production of IFN-gamma. Arginine 0-5 interferon gamma Homo sapiens 161-170 22921904-6 2012 When stimulated with Poly (I:C) in vivo, attenuated accumulating in the liver and weaker expression of GranzymeB, TRAIL and FasL of NK1.1(+)CD3(-) cells were observed of IFN-gamma(-/-) mice. poly 21-25 interferon gamma Homo sapiens 170-179 22921904-6 2012 When stimulated with Poly (I:C) in vivo, attenuated accumulating in the liver and weaker expression of GranzymeB, TRAIL and FasL of NK1.1(+)CD3(-) cells were observed of IFN-gamma(-/-) mice. Iodine 27-28 interferon gamma Homo sapiens 170-179 22921904-6 2012 When stimulated with Poly (I:C) in vivo, attenuated accumulating in the liver and weaker expression of GranzymeB, TRAIL and FasL of NK1.1(+)CD3(-) cells were observed of IFN-gamma(-/-) mice. Carbon 29-30 interferon gamma Homo sapiens 170-179 22358381-6 2012 Within Group I, vitamin D levels showed a negative correlation with IgE and IL-4 levels, and a positive correlation with IFN-gamma (p < 0.05). Vitamin D 16-25 interferon gamma Homo sapiens 121-130 22358381-1 2012 We aimed to study Th1/Th2 cell balance by measuring the levels of cytokines IL-4, IL-10, and IFN-gamma, which play an important role in the immune response of patients with allergic rhinitis and/or nasal polyps, and determine the correlation between Th1/Th2 cell balance and 1alpha,25-dihydroxyvitamin D(3), an active metabolite of vitamin D. Dihydroxycholecalciferols 285-303 interferon gamma Homo sapiens 93-102 22588246-12 2012 Activated CD4- and CD8-positive T cells were increased, and HBV- and HCV-specific IFN-gamma-secreting cells were also increased during Peg-IFN/RBV-therapy. peg-ifn 135-142 interferon gamma Homo sapiens 82-91 22358381-1 2012 We aimed to study Th1/Th2 cell balance by measuring the levels of cytokines IL-4, IL-10, and IFN-gamma, which play an important role in the immune response of patients with allergic rhinitis and/or nasal polyps, and determine the correlation between Th1/Th2 cell balance and 1alpha,25-dihydroxyvitamin D(3), an active metabolite of vitamin D. Vitamin D 294-303 interferon gamma Homo sapiens 93-102 23045481-9 2012 TcdA/TcdB exposure increased the expression of a number of inflammatory mediators associated with human CDI, including interleukin-6 (IL-6), gamma interferon (IFN-gamma), and IL-1beta. tcda 0-4 interferon gamma Homo sapiens 141-168 23045481-9 2012 TcdA/TcdB exposure increased the expression of a number of inflammatory mediators associated with human CDI, including interleukin-6 (IL-6), gamma interferon (IFN-gamma), and IL-1beta. trimethylaminocarboxyldihydroboran 5-9 interferon gamma Homo sapiens 141-168 22847544-6 2012 The level of beta-glucan induced interferon (IFN)-gamma in her blood cells was significantly low. beta-Glucans 13-24 interferon gamma Homo sapiens 33-55 23125412-3 2012 In this article, we show that IFN-gamma inhibits Th9 differentiation both in vitro and in vivo. TH9 49-52 interferon gamma Homo sapiens 30-39 22588246-12 2012 Activated CD4- and CD8-positive T cells were increased, and HBV- and HCV-specific IFN-gamma-secreting cells were also increased during Peg-IFN/RBV-therapy. Ribavirin 143-146 interferon gamma Homo sapiens 82-91 23158971-9 2012 After full covariate adjustment, circulating alpha-tocopherol was inversely associated with IFN-gamma and regulated upon activation normal T-cell expressed and secreted (RANTES). alpha-Tocopherol 45-61 interferon gamma Homo sapiens 92-101 22707092-5 2012 IFN-gamma were positively correlated with total cholesterol (r = 0.425; P = 0.019) and LDL-cholesterol (r = 0.391; P = 0.032) levels in patients. Cholesterol 48-59 interferon gamma Homo sapiens 0-9 22707092-5 2012 IFN-gamma were positively correlated with total cholesterol (r = 0.425; P = 0.019) and LDL-cholesterol (r = 0.391; P = 0.032) levels in patients. Cholesterol 91-102 interferon gamma Homo sapiens 0-9 24278618-6 2012 We found that the chloroform fraction of C. tschonoskii inhibited MDC at both the protein and mRNA levels in HaCaT cells, acting via the inhibition of STAT1 in the IFN-gamma signaling pathway. Chloroform 18-28 interferon gamma Homo sapiens 164-173 24278621-8 2012 The levels of IL-1 in the thymus and spleen; INF-gamma in serum; IL-2, IL-6, and IL-10 in the thymus; and IL-10 and IFN-gamma in the spleen decreased after ZEA administration. Zearalenone 156-159 interferon gamma Homo sapiens 116-125 22955317-9 2012 Isolated CD11b(+)CD14(+) cells suppressed CD8(+) T-cell proliferation and IFN-gamma production, and the former effect was attenuated by the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine hydrochloride, arginase inhibitor N-hydroxy-nor-l-arginine (nor-NOHA), and blocking antibodies for IL-4Ralpha(+) and IL-10. pimagedine 189-217 interferon gamma Homo sapiens 74-83 23175341-6 2012 The purpose of the study is to evaluate the levels of selected inflammatory cytokines, IL-2, IL-4, IFN-gamma and TNF-alpha, in the serum after treatment with itraconazole. Itraconazole 158-170 interferon gamma Homo sapiens 99-108 23158971-10 2012 We observed an unexpected positive association between ascorbic acid and IFN-gamma. Ascorbic Acid 55-68 interferon gamma Homo sapiens 73-82 22993407-3 2012 Divalent disaccharide 1,4-bis(alpha-D-mannopyranosyloxy)butane induced TNF and some molecules induced low levels of gamma interferon (IFN-gamma) in human peripheral blood mononuclear cells (PBMC). divalent disaccharide 1,4-bis(alpha-d-mannopyranosyloxy)butane 0-62 interferon gamma Homo sapiens 116-143 22978645-13 2012 As compared with tuberculin skin test, interferon-gamma release assay reverted in nearly half of isoniazid-treated patients for latent tuberculosis. Isoniazid 97-106 interferon gamma Homo sapiens 39-55 22898392-9 2012 The addition of IGF-I (100ng/ml) to whole blood cultures inhibited the secretion of IFN-gamma from PMA/ionomycin-stimulated cord blood mononuclear cells (CBMC). Ionomycin 103-112 interferon gamma Homo sapiens 84-93 22898392-9 2012 The addition of IGF-I (100ng/ml) to whole blood cultures inhibited the secretion of IFN-gamma from PMA/ionomycin-stimulated cord blood mononuclear cells (CBMC). cbmc 154-158 interferon gamma Homo sapiens 84-93 22961735-5 2012 RESULTS: Active pulmonary TB generally showed an excess of TNF-alpha(+) subsets over IFN-gamma(+) subsets, paralleled by decreased CD27 expression on activated IFN-gamma(+) or CD154(+) CD4 T-cells. Terbium 26-28 interferon gamma Homo sapiens 85-94 22961735-6 2012 The single subset distinguishing best between active pulmonary TB and high TB exposure was CD154(+) /TNF-alpha(+) / IFN-gamma(-) /IL-2(-) /degranulation(-) (AUROC 0.90). Terbium 63-65 interferon gamma Homo sapiens 116-128 22961735-6 2012 The single subset distinguishing best between active pulmonary TB and high TB exposure was CD154(+) /TNF-alpha(+) / IFN-gamma(-) /IL-2(-) /degranulation(-) (AUROC 0.90). Terbium 75-77 interferon gamma Homo sapiens 116-128 23028055-10 2012 We also show a significant increase in IFN-gamma production and cytotoxic activity in TILs that acquired H-RasG12V compared to TILs that acquired a different H-Ras mutant. h-rasg12v 105-114 interferon gamma Homo sapiens 39-48 22766105-5 2012 Serum IFN-gamma (in patients with detectable IFN-gamma) and TNF-alpha were significantly higher in MC+HCV than in controls (p<0.05, Mann-Whitney U test; p<0.0001, Mann-Whitney U-test; respectively). mc+hcv 99-105 interferon gamma Homo sapiens 6-15 22766105-5 2012 Serum IFN-gamma (in patients with detectable IFN-gamma) and TNF-alpha were significantly higher in MC+HCV than in controls (p<0.05, Mann-Whitney U test; p<0.0001, Mann-Whitney U-test; respectively). mc+hcv 99-105 interferon gamma Homo sapiens 45-54 22766105-9 2012 A strong relation among high levels of circulating IFN-gamma, TNF-alpha and serum CXCL9 has been shown in MC+HCV. Methylcholanthrene 106-108 interferon gamma Homo sapiens 51-60 22915814-5 2012 Poly(I C) pretreatment upregulated beta interferon (IFN-beta), IFN-gamma, IL-1beta, and tumor necrosis factor (TNF) gene expression in the lungs. Poly I-C 0-8 interferon gamma Homo sapiens 63-72 22802109-6 2012 RESULTS: Combined administration of ETN/MTX significantly inhibited the proliferation of T lymphocytes, decreased serum IL-6, TNF-alpha, IL-1beta, RANKL and macrophage supernatant IL-17, LT-alpha, increased serum IFN-gamma and macrophage supernatant IL-10. Methotrexate 40-43 interferon gamma Homo sapiens 213-222 23042198-11 2012 Simvastatin completely reversed this sepsis-mediated inhibition of IFN-gamma and IL-4 formation in the spleen. Simvastatin 0-11 interferon gamma Homo sapiens 67-76 22896622-4 2012 During primary RSV infection, increased numbers of RSV-specific CD4(+) T cells producing gamma interferon (IFN-gamma) were found in the lungs at days 8 to 10 postinfection in mice receiving diet containing short-chain galactooligosacharides, long-chain fructooligosaccharides, and pectin-derived acidic oligosaccharides (termed scGOS/lcFOS/pAOS). galactooligosacharides 218-240 interferon gamma Homo sapiens 107-116 22896622-4 2012 During primary RSV infection, increased numbers of RSV-specific CD4(+) T cells producing gamma interferon (IFN-gamma) were found in the lungs at days 8 to 10 postinfection in mice receiving diet containing short-chain galactooligosacharides, long-chain fructooligosaccharides, and pectin-derived acidic oligosaccharides (termed scGOS/lcFOS/pAOS). Oligosaccharides 259-275 interferon gamma Homo sapiens 107-116 23162658-10 2012 The caspase inhibitor Z-VAD-FMK and the STAT3 inhibitor blocked this IFNgamma-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 22-31 interferon gamma Homo sapiens 69-77 22924677-0 2012 The serotonin receptor-antagonist ondansetron induces significant increases in the expression of interferon-gamma which correlate with antiproliferative properties in the acute lymphoblastic leukaemia cell line REH. Ondansetron 34-45 interferon gamma Homo sapiens 97-113 22948153-6 2012 Inhibition of p38 with SB203580 abrogated adiponectin-induced IFN-gamma production, indicating that adiponectin enhances T(H)1 differentiation through the activation of the p38-STAT4-T-bet axis. SB 203580 23-31 interferon gamma Homo sapiens 62-71 22943853-3 2012 In present study, we investigated the effect of spinasterol-Glc on production of TARC/CCL17 induced by TNF-alpha and IFN-gamma in human HaCaT keratinocytes. spinasterol 48-59 interferon gamma Homo sapiens 117-126 22943853-3 2012 In present study, we investigated the effect of spinasterol-Glc on production of TARC/CCL17 induced by TNF-alpha and IFN-gamma in human HaCaT keratinocytes. Glucose 60-63 interferon gamma Homo sapiens 117-126 22943853-4 2012 Spinasterol-Glc inhibited the mRNA and protein expression of TARC/CCL17 induced by TNF-alpha/IFN-gamma in a dose-dependent manner. spinasterol 0-11 interferon gamma Homo sapiens 93-102 22943853-4 2012 Spinasterol-Glc inhibited the mRNA and protein expression of TARC/CCL17 induced by TNF-alpha/IFN-gamma in a dose-dependent manner. Glucose 12-15 interferon gamma Homo sapiens 93-102 22943853-5 2012 Inhibitors of c-Raf-1, p38 MAPK, and JAK2, suppressed the TNF-alpha/IFN-gamma-induced production of TARC/CCL17, and phosphorylation of these signaling molecules were attenuated by spinasterol-Glc. 3-O-beta-D-glucopyranosyl-spinasterol 180-195 interferon gamma Homo sapiens 68-77 22943853-7 2012 We demonstrated that spinasterol-Glc suppressed the NF-kappaB-driven and the GAS-driven expression of luciferase reporter gene induced by TNF-alpha and IFN-gamma. 3-O-beta-D-glucopyranosyl-spinasterol 21-36 interferon gamma Homo sapiens 152-161 22972933-4 2012 Dendritic cells treated with LPS and 3-methyladenine secreted enhanced levels of both IL-1beta and IL-23, and supernatants from these cells stimulated the innate secretion of IL-17, IFN-gamma, and IL-22 by gammadelta T cells. 3-methyladenine 37-52 interferon gamma Homo sapiens 182-191 22784028-0 2012 IFN-gamma inhibits osteopontin expression in human decidual stromal cells and can be attenuated by 1alpha,25-dihydroxyvitamin D3. Calcitriol 99-128 interferon gamma Homo sapiens 0-9 23060289-2 2012 In this study, we used lectin-binding ELISA to assess the carbohydrate compositions of THP, BSA, IgG, TNF-alpha, and IFN-g. Carbohydrates 58-70 interferon gamma Homo sapiens 117-122 22632269-0 2012 Dysfunction in cytochrome c oxidase caused by excessive nitric oxide in human lens epithelial cells stimulated with interferon-gamma and lipopolysaccharide. Nitric Oxide 56-68 interferon gamma Homo sapiens 116-132 22809665-7 2012 We also found that Nac pre-administration resulted in lower blood levels of the cytokines and chemokines interferon-gamma, interleukin-10, CCL2, CCL4, and CCL5, but only lowered CCL4 in the cerebral cortex and hippocampus. nac 19-22 interferon gamma Homo sapiens 105-121 22521469-6 2012 RESULTS: CLA significantly suppressed the ability of peripheral blood CD4+ and CD8+ T cell subsets to produce IFN-gamma, TNF-alpha and IL-17 and lymphoproliferation at week 12. Linoleic Acids, Conjugated 9-12 interferon gamma Homo sapiens 110-119 22820625-6 2012 A positive correlation of MMPs with TIMPs in TB, MMP-1 and -9 with IL-6 in TB PF and MMP-9 with IFN-gamma in NTB PF was observed. naltrindole benzofuran 109-112 interferon gamma Homo sapiens 96-105 22704696-2 2012 Interferon (IFN)-gamma is an inflammatory cytokine that regulates vitamin D metabolism in isolated immune cells, but data suggesting this regulation exists in vivo is lacking. Vitamin D 66-75 interferon gamma Homo sapiens 0-22 22704696-3 2012 The purpose of this study, therefore, was to associate circulating IFN-gamma perturbations with 25(OH)D and 1,25-dihydroxyvitamin D (1,25(OH)D) alterations during inflammatory stress in young adults recovering from anterior cruciate ligament (ACL) reconstruction. 1,25-dihydroxyvitamin D 108-131 interferon gamma Homo sapiens 67-76 22704696-8 2012 We conclude that IFN-gamma contributes to the decrease in vitamin D and the conversion of vitamin D to its active hormonal form in the circulation during inflammatory insult in humans. Vitamin D 58-67 interferon gamma Homo sapiens 17-26 22704696-8 2012 We conclude that IFN-gamma contributes to the decrease in vitamin D and the conversion of vitamin D to its active hormonal form in the circulation during inflammatory insult in humans. Vitamin D 90-99 interferon gamma Homo sapiens 17-26 22947346-7 2012 Dexamethasone potentiated TNF-alpha- and IFN-gamma-induced CX3CL1 release equally in all 3 groups. Dexamethasone 0-13 interferon gamma Homo sapiens 41-50 22534863-1 2012 PURPOSE: The intravenous administration of alpha-Galactosylceramide (alpha-GalCer)-pulsed antigen presenting cells (APCs) is well tolerated and the increased IFN-gamma producing cells in the peripheral blood after the treatment appeared to be associated with prolonged survival. alpha-galactosylceramide 43-67 interferon gamma Homo sapiens 158-167 22884781-7 2012 In contrast, the addition of Th1 cytokines (GM-CSF/IFN-gamma/TNF-alpha) at concentrations of 2.5 or 10nM resulted in a slight increase in SC ceramide levels, which were accompanied by no change or an increase in the expression of those genes encoding sphingolipid metabolic enzymes in the epidermis. Ceramides 141-149 interferon gamma Homo sapiens 51-60 22884781-7 2012 In contrast, the addition of Th1 cytokines (GM-CSF/IFN-gamma/TNF-alpha) at concentrations of 2.5 or 10nM resulted in a slight increase in SC ceramide levels, which were accompanied by no change or an increase in the expression of those genes encoding sphingolipid metabolic enzymes in the epidermis. Sphingolipids 251-263 interferon gamma Homo sapiens 51-60 22836039-7 2012 Addition of lysine to the enzymatic modification of gluten normalized interferon gamma, antibodies, transglutaminase activity and immunohistochemical expression of transglutaminase type 2. Lysine 12-18 interferon gamma Homo sapiens 70-86 22996369-6 2012 Pemetrexed increased intracellular accumulation of interferon gamma (IFNgamma) in NK cells that correlated negatively with survival. Pemetrexed 0-10 interferon gamma Homo sapiens 51-78 22980179-7 2012 However, when comparing teeth that received the medication with those that did not, expression levels of IL-1beta, IFN-gamma, and IL-10 were statistically lower in those teeth that received calcium hydroxide. Calcium Hydroxide 190-207 interferon gamma Homo sapiens 115-124 22996369-7 2012 Addition of gemcitabine decreased IFNgamma-producing NK cells to baseline. gemcitabine 12-23 interferon gamma Homo sapiens 34-42 22996369-13 2012 Although pemetrexed therapy increased activation of a subset of NK cells to produce IFNgamma, addition of gemcitabine abated those responses, decreasing IFNgamma-producing NK cells, whereas NK cells producing interleukin-2 without IFNgamma at this timepoint positively correlated with survival. Pemetrexed 9-19 interferon gamma Homo sapiens 84-92 22996369-13 2012 Although pemetrexed therapy increased activation of a subset of NK cells to produce IFNgamma, addition of gemcitabine abated those responses, decreasing IFNgamma-producing NK cells, whereas NK cells producing interleukin-2 without IFNgamma at this timepoint positively correlated with survival. gemcitabine 106-117 interferon gamma Homo sapiens 153-161 22996369-13 2012 Although pemetrexed therapy increased activation of a subset of NK cells to produce IFNgamma, addition of gemcitabine abated those responses, decreasing IFNgamma-producing NK cells, whereas NK cells producing interleukin-2 without IFNgamma at this timepoint positively correlated with survival. gemcitabine 106-117 interferon gamma Homo sapiens 153-161 22823229-2 2012 We have previously reported that transforming growth factor beta1 (TGFbeta1) released by hippocampal cells modulates interferon-gamma (IFNgamma)-induced production of O(2) (-) and NO by glial cells. Superoxides 167-171 interferon gamma Homo sapiens 117-133 22753954-8 2012 We found that pharmacological inhibition of P2X4 receptors with TNP-ATP inhibited transcriptional up-regulation of TNF-alpha and IFN-gamma in gammadelta T cells stimulated with anti-CD3/CD28-coated beads or IPP. Adenosine Triphosphate 68-71 interferon gamma Homo sapiens 129-138 22823229-2 2012 We have previously reported that transforming growth factor beta1 (TGFbeta1) released by hippocampal cells modulates interferon-gamma (IFNgamma)-induced production of O(2) (-) and NO by glial cells. Superoxides 167-171 interferon gamma Homo sapiens 135-143 22823229-4 2012 We found that costimulation with TGFbeta1 decreased IFNgamma-induced phosphorylation of signal transducer and activator of transcription-type-1 (STAT1) and extracellular signal-regulated kinase (ERK), which correlated with a reduced O(2) (-) and NO production in mixed and purified glial cultures. Superoxides 233-237 interferon gamma Homo sapiens 52-60 22823229-5 2012 Moreover, IFNgamma caused a decrease in TGFbeta1-mediated phosphorylation of P38, whereas pre-treatment with ERK and P38 inhibitors decreased IFNgamma-induced phosphorylation of STAT1 on serine727 and production of radical species. serine727 187-196 interferon gamma Homo sapiens 10-18 22823229-5 2012 Moreover, IFNgamma caused a decrease in TGFbeta1-mediated phosphorylation of P38, whereas pre-treatment with ERK and P38 inhibitors decreased IFNgamma-induced phosphorylation of STAT1 on serine727 and production of radical species. serine727 187-196 interferon gamma Homo sapiens 142-150 22729230-0 2012 Interferon gamma stimulates accumulation of gas phase nitric oxide in differentiated cultures of normal and cystic fibrosis airway epithelial cells. Nitric Oxide 54-66 interferon gamma Homo sapiens 0-16 22906662-0 2012 Exploration of the correlations between interferon-gamma in patient serum and HEPACAM in bladder transitional cell carcinoma, and the interferon-gamma mechanism inhibiting BIU-87 proliferation. biu 172-175 interferon gamma Homo sapiens 134-150 22906662-3 2012 To our knowledge whether interferon-gamma inhibits BIU-87 proliferation and re-expresses HEPACAM mRNA is still unknown. biu 51-54 interferon gamma Homo sapiens 25-41 22729230-10 2012 The results also demonstrate that IFNgamma treatment of differentiated cells results in higher levels of gNO than treatment of undifferentiated cells, and that a layer of fluid on the apical surface drastically reduces the amount of gNO, possibly by limiting the availability of oxygen. CP 544326 105-108 interferon gamma Homo sapiens 34-42 22906662-8 2012 Under interferon-gamma stimulation we detected BIU-87 proliferation by MTT assay. biu 47-50 interferon gamma Homo sapiens 6-22 22906662-8 2012 Under interferon-gamma stimulation we detected BIU-87 proliferation by MTT assay. monooxyethylene trimethylolpropane tristearate 71-74 interferon gamma Homo sapiens 6-22 22906662-15 2012 In vitro interferon-gamma inhibited BIU-87 proliferation (p <0.01) and slightly re-expressed HEPACAM mRNA (p <0.05). biu 36-39 interferon gamma Homo sapiens 9-25 22906662-17 2012 CONCLUSIONS: Results suggest an important connection between HEPACAM and interferon-gamma, which may inhibit BIU-87 proliferation through HEPACAM re-expression and p21(WAF1) up-regulation to arrest cells at the G(0)/G(1) phase. biu 109-112 interferon gamma Homo sapiens 73-89 22562951-0 2012 Classification of individuals based on ex-vivo glatiramer acetate-induced interferon-gamma and interleukin-4 response. Glatiramer Acetate 47-65 interferon gamma Homo sapiens 74-90 22766315-4 2012 Moreover, we evaluated the potential effect of treatment with budesonide and/or formoterol on IFN-gamma secretion in vitro. Budesonide 62-72 interferon gamma Homo sapiens 94-103 22548241-13 2012 Priming with GM-CSF or TNF-alpha was more effective than IFN-gamma in compensating for the inhibitory PGE(2) effect, since these cytokines induce cells to produce higher H(2)O(2) and TNF-alpha levels. Prostaglandins E 102-105 interferon gamma Homo sapiens 57-66 22548241-13 2012 Priming with GM-CSF or TNF-alpha was more effective than IFN-gamma in compensating for the inhibitory PGE(2) effect, since these cytokines induce cells to produce higher H(2)O(2) and TNF-alpha levels. Water 170-175 interferon gamma Homo sapiens 57-66 22947424-0 2012 Arachidonic acid and its COX1/2 metabolites inhibit interferon-gamma mediated induction of indoleamine-2,3 dioxygenase in THP-1 cells and human monocytes. Arachidonic Acid 0-16 interferon gamma Homo sapiens 52-68 22947424-1 2012 Using human acute monocytic leukaemic THP-1 cells and human primary monocytes, this study examined the ability of arachidonic acid (AA) to modulate the activity of the IFNgamma signalling cascade and its downstream effector indoleamine 2,3-dioxygenase (IDO). Arachidonic Acid 114-130 interferon gamma Homo sapiens 168-176 22947424-3 2012 Further mechanistic analysis revealed that AA interfered with the transcriptional function of the IFNgamma signalling pathway by reducing phosphorylation of signal transducer and activator of transcription (STAT1) on tyrosine 701. Tyrosine 217-225 interferon gamma Homo sapiens 98-106 22947424-7 2012 We now have evidence demonstrating that the AA metabolites, prostaglandins A(2) and D(2,) were highly inhibitory towards the IFNgamma pathway, while prostaglandin E(2) had no effect. Prostaglandins A 60-76 interferon gamma Homo sapiens 125-133 22766315-4 2012 Moreover, we evaluated the potential effect of treatment with budesonide and/or formoterol on IFN-gamma secretion in vitro. Formoterol Fumarate 80-90 interferon gamma Homo sapiens 94-103 22766315-13 2012 Even if in vitro experiments with budesonide, alone or in combination with formoterol, showed a modulation of NKG2D receptor expression and IFN-gamma production, our ex vivo results show that real life LABA and ICS treatment does not influence peripheral NK cells count and their receptors phenotype. Budesonide 34-44 interferon gamma Homo sapiens 140-149 22766315-13 2012 Even if in vitro experiments with budesonide, alone or in combination with formoterol, showed a modulation of NKG2D receptor expression and IFN-gamma production, our ex vivo results show that real life LABA and ICS treatment does not influence peripheral NK cells count and their receptors phenotype. Formoterol Fumarate 75-85 interferon gamma Homo sapiens 140-149 22982856-4 2012 Rosiglitazone inhibited GVHD-induced increases in serum levels of tumor necrosis factor-alpha, interferon-gamma, interleukin (IL)-6, and IL-12, and the GVHD-induced decreases in transforming growth factor-beta and IL-10. Rosiglitazone 0-13 interferon gamma Homo sapiens 95-111 23006534-9 2012 RESULTS: Incubation with LPS, LTA or TCS significantly increased TNF-alpha, IL-1beta, IL-6, IL-8, IFN-gamma and IL-2 in comparison to incubation with RPMI alone. lipoteichoic acid 30-33 interferon gamma Homo sapiens 98-107 22929409-7 2012 Also, the CsA sensitivity of IFN-gamma (r = 0.131, P < 0.0001) and GM-CSF (r = 0.036, P < 0.01) were inversely correlated with chronological age. Cyclosporine 10-13 interferon gamma Homo sapiens 29-38 22954802-2 2012 We investigated the in-vitro function of separated CD3(+)CD4(+)CD25(+)Foxp3(+)IFNgamma(+) PBL that were induced by phorbol-12-myristate-13-acetate(PMA)/Ionomycin or alloantigenic stimulation. Tetradecanoylphorbol Acetate 115-146 interferon gamma Homo sapiens 78-86 22954802-4 2012 CD4(+)CD25(+)IFNgamma(+) PBL separated from PMA/Ionomycin-stimulated PBL of healthy controls inhibited secondary cell cultures of autologous PBL. Ionomycin 48-57 interferon gamma Homo sapiens 13-21 23006534-9 2012 RESULTS: Incubation with LPS, LTA or TCS significantly increased TNF-alpha, IL-1beta, IL-6, IL-8, IFN-gamma and IL-2 in comparison to incubation with RPMI alone. Technetium 37-40 interferon gamma Homo sapiens 98-107 23009259-8 2012 CONCLUSIONS: Exposures to SHS and AAP are associated with significant hypermethylation and decreased expression of IFN-gamma in Teffs and Foxp3 in Tregs. aap 34-37 interferon gamma Homo sapiens 115-124 22841723-3 2012 These phenoxybenzoxaboroles can be optimized to generate submicromolar potency enzyme inhibitors, which inhibit TNF-alpha, IL-2, IFN-gamma, IL-5 and IL-10 activities in vitro and show safety and efficacy for topical treatment of human psoriasis. phenoxybenzoxaboroles 6-27 interferon gamma Homo sapiens 129-138 22561311-3 2012 We have previously reported that defined cocktails of cytokines, involving TNFalpha and IFNgamma, induce mature type-1 polarized DCs (DC1s) which produce strongly elevated levels of IL-12 and CXCL10/IP10 upon CD40 ligation compared to "standard" PGE2-matured DCs (sDCs; matured with IL-1beta, IL-6, TNFalpha, and PGE2) and show higher CTL-inducing activity. Dinoprostone 246-250 interferon gamma Homo sapiens 88-96 23114146-7 2012 After the Dex-treated MSC were co-cultured with IFN-gamma for 12 h, the immunoregulatory ability of MSC was recovered in a certain degree. Dexamethasone 10-13 interferon gamma Homo sapiens 48-57 23114146-8 2012 It is concluded that the Dex impairs the immunosuppressive ability of MSC, the IFN-gamma can protect and reverse the immunosuppressive ability of MSC impaired by Dex, so that, when the immunoregulatory activity of MSC is investigated, it is necessary to avoid adding Dex in the culture medium. Dexamethasone 162-165 interferon gamma Homo sapiens 79-88 22561311-3 2012 We have previously reported that defined cocktails of cytokines, involving TNFalpha and IFNgamma, induce mature type-1 polarized DCs (DC1s) which produce strongly elevated levels of IL-12 and CXCL10/IP10 upon CD40 ligation compared to "standard" PGE2-matured DCs (sDCs; matured with IL-1beta, IL-6, TNFalpha, and PGE2) and show higher CTL-inducing activity. Dinoprostone 313-317 interferon gamma Homo sapiens 88-96 22896638-5 2012 Sardinian MS patients frequently carry a low Ifng expresser allele, suggesting that inadequate IFN-gamma may undermine vitamin D3-mediated inhibition of demyelinating disease. Cholecalciferol 119-129 interferon gamma Homo sapiens 45-49 22896630-0 2012 Tryptophan depletion and the kinase GCN2 mediate IFN-gamma-induced autophagy. Tryptophan 0-10 interferon gamma Homo sapiens 49-58 22896638-5 2012 Sardinian MS patients frequently carry a low Ifng expresser allele, suggesting that inadequate IFN-gamma may undermine vitamin D3-mediated inhibition of demyelinating disease. Cholecalciferol 119-129 interferon gamma Homo sapiens 95-104 22896630-5 2012 Our results indicate that IFN-gamma promotes tryptophan depletion, activates the eIF2alpha kinase general control nonderepressible-2 (GCN2), and leads to an increase in the autophagic flux. Tryptophan 45-55 interferon gamma Homo sapiens 26-35 23054711-0 2012 Ingenane-type diterpenes with a modulatory effect on IFN-gamma production from the roots of Euphorbia kansui. ingenane 0-8 interferon gamma Homo sapiens 53-62 22896630-6 2012 Further, tryptophan supplementation and RNA interference directed against GCN2 inhibited IFN-gamma-induced autophagy. Tryptophan 9-19 interferon gamma Homo sapiens 89-98 22823162-2 2012 In this study, we demonstrate that the Toll-like receptor-2 agonist Pam2Cys, when administered intranasally, triggers a cascade of inflammatory and innate immune signals, acting as an immunostimulant by attracting neutrophils and macrophages and inducing secretion of IL-2, IL-6, IL-10, IFN-gamma, MCP-1 and TNF-alpha. S-(2,3-bis(palmitoyloxy)propyl)cysteine 68-75 interferon gamma Homo sapiens 287-296 22772752-8 2012 In sum, adenosine signaling is influenced by tissue inflammation and injury through induction of receptors and enzymes and has generally inhibitory effects on lymphocyte migration into inflamed tissues due to protein kinase A-mediated effects on adhesion molecules, interferon gamma production, and endothelial barrier function. Adenosine 8-17 interferon gamma Homo sapiens 266-282 23054711-0 2012 Ingenane-type diterpenes with a modulatory effect on IFN-gamma production from the roots of Euphorbia kansui. Diterpenes 14-24 interferon gamma Homo sapiens 53-62 23059811-3 2012 We show that d-limonene and its metabolites limonene-1-2-diol and perillic acid inhibit the production by CD3(+)CD4(+) T cells of IFN-gamma, IL-2, TNF-alpha, IL-4 and IL-13, and the production by CD3(+)CD8(+) T cells of IFN-gamma, IL-2, and TNF-alpha. limonene-1-2-diol 44-61 interferon gamma Homo sapiens 220-229 22433003-11 2012 Licofelone reduced interleukin-18-induced phosphorylation of p38 mitogen-activated protein kinase and suppressed monocyte chemotactic protein-1 and interferon-gamma synthesis. licofelone 0-10 interferon gamma Homo sapiens 148-164 22682938-0 2012 Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-alpha plus IFN-gamma on polystyrene and the role of p53 activation. Polystyrenes 113-124 interferon gamma Homo sapiens 100-109 23059811-3 2012 We show that d-limonene and its metabolites limonene-1-2-diol and perillic acid inhibit the production by CD3(+)CD4(+) T cells of IFN-gamma, IL-2, TNF-alpha, IL-4 and IL-13, and the production by CD3(+)CD8(+) T cells of IFN-gamma, IL-2, and TNF-alpha. Limonene 13-23 interferon gamma Homo sapiens 130-139 23059811-3 2012 We show that d-limonene and its metabolites limonene-1-2-diol and perillic acid inhibit the production by CD3(+)CD4(+) T cells of IFN-gamma, IL-2, TNF-alpha, IL-4 and IL-13, and the production by CD3(+)CD8(+) T cells of IFN-gamma, IL-2, and TNF-alpha. Limonene 13-23 interferon gamma Homo sapiens 220-229 23059811-3 2012 We show that d-limonene and its metabolites limonene-1-2-diol and perillic acid inhibit the production by CD3(+)CD4(+) T cells of IFN-gamma, IL-2, TNF-alpha, IL-4 and IL-13, and the production by CD3(+)CD8(+) T cells of IFN-gamma, IL-2, and TNF-alpha. limonene-1-2-diol 44-61 interferon gamma Homo sapiens 130-139 23059811-3 2012 We show that d-limonene and its metabolites limonene-1-2-diol and perillic acid inhibit the production by CD3(+)CD4(+) T cells of IFN-gamma, IL-2, TNF-alpha, IL-4 and IL-13, and the production by CD3(+)CD8(+) T cells of IFN-gamma, IL-2, and TNF-alpha. perillic acid 66-79 interferon gamma Homo sapiens 130-139 23059811-3 2012 We show that d-limonene and its metabolites limonene-1-2-diol and perillic acid inhibit the production by CD3(+)CD4(+) T cells of IFN-gamma, IL-2, TNF-alpha, IL-4 and IL-13, and the production by CD3(+)CD8(+) T cells of IFN-gamma, IL-2, and TNF-alpha. perillic acid 66-79 interferon gamma Homo sapiens 220-229 22775529-7 2012 PL-MSCs inhibited phytohemaglutinine-induced proliferation of PB-MNCs and production of IL-2, IFNgamma and IL-5 in the co-culture, probably via TGF-beta-dependent mechanisms. phytohemaglutinine 18-36 interferon gamma Homo sapiens 94-102 22705049-1 2012 We report the effect of an immunomodulatory and anti-mycobacterial naphthoquinone, lapachol, on the bi-dimensional patterns of protein expression of toll-like receptor 2 (TLR2)-agonised and IFN-gamma-treated THP-1 macrophages. Naphthoquinones 67-81 interferon gamma Homo sapiens 190-199 22705049-1 2012 We report the effect of an immunomodulatory and anti-mycobacterial naphthoquinone, lapachol, on the bi-dimensional patterns of protein expression of toll-like receptor 2 (TLR2)-agonised and IFN-gamma-treated THP-1 macrophages. lapachol 83-91 interferon gamma Homo sapiens 190-199 22795618-8 2012 Furthermore, it has been found that altered peptide ligands, which are produced through single alanine residue substitutions at a critical TCR contact position, abolish the T cell proliferation and IFN-gamma production induced by K17 pathogenic peptides. Alanine 95-102 interferon gamma Homo sapiens 198-207 22741783-0 2012 Synthesis and immunomodulation of human lymphocyte proliferation and cytokine (interferon-gamma) production of four novel leflunomide analogues. Leflunomide 122-133 interferon gamma Homo sapiens 79-95 22741783-9 2012 Compound 6a (R=CH(3) containing a trifluoromethylaniline moiety) suppressed lymphocyte proliferation and IFN-gamma production with a potency comparable to the positive control. methyl radical 15-20 interferon gamma Homo sapiens 105-114 23741252-3 2012 In the present study, we examined the effects of (-)-epigallocatechin gallate (EGCG), the major catechin in green tea, on the inhibition of IDO expression induced by interferon (IFN)-gamma in human CRC cells. epigallocatechin gallate 49-77 interferon gamma Homo sapiens 166-188 22659089-2 2012 The CCBs nimodipine (NDP) and verapamil (VPM) both significantly suppressed toxic secretions from human astrocytes and astrocytoma U-373 MG cells that were induced by interferon (IFN)-gamma. Nimodipine 9-19 interferon gamma Homo sapiens 167-189 22659089-2 2012 The CCBs nimodipine (NDP) and verapamil (VPM) both significantly suppressed toxic secretions from human astrocytes and astrocytoma U-373 MG cells that were induced by interferon (IFN)-gamma. Nimodipine 21-24 interferon gamma Homo sapiens 167-189 22659089-2 2012 The CCBs nimodipine (NDP) and verapamil (VPM) both significantly suppressed toxic secretions from human astrocytes and astrocytoma U-373 MG cells that were induced by interferon (IFN)-gamma. Verapamil 30-39 interferon gamma Homo sapiens 167-189 22659089-2 2012 The CCBs nimodipine (NDP) and verapamil (VPM) both significantly suppressed toxic secretions from human astrocytes and astrocytoma U-373 MG cells that were induced by interferon (IFN)-gamma. Verapamil 41-44 interferon gamma Homo sapiens 167-189 22659089-3 2012 NDP also inhibited neurotoxic secretions of human microglia and monocytic THP-1 cells that were induced by the combination of lipopolysaccharide and IFN-gamma. Nimodipine 0-3 interferon gamma Homo sapiens 149-158 22659089-4 2012 In human astrocytes, both NDP and VPM reduced IFN-gamma-induced phosphorylation of signal transducer and activator of transcription (STAT) 3. Nimodipine 26-29 interferon gamma Homo sapiens 46-55 22659089-4 2012 In human astrocytes, both NDP and VPM reduced IFN-gamma-induced phosphorylation of signal transducer and activator of transcription (STAT) 3. Verapamil 34-37 interferon gamma Homo sapiens 46-55 23741252-3 2012 In the present study, we examined the effects of (-)-epigallocatechin gallate (EGCG), the major catechin in green tea, on the inhibition of IDO expression induced by interferon (IFN)-gamma in human CRC cells. epigallocatechin gallate 79-83 interferon gamma Homo sapiens 166-188 23741252-3 2012 In the present study, we examined the effects of (-)-epigallocatechin gallate (EGCG), the major catechin in green tea, on the inhibition of IDO expression induced by interferon (IFN)-gamma in human CRC cells. Catechin 61-69 interferon gamma Homo sapiens 166-188 23741252-5 2012 Treatment of SW837 cells with EGCG significantly decreased IFN-gamma-induced expression of IDO protein and mRNA in a dose-dependent manner. epigallocatechin gallate 30-34 interferon gamma Homo sapiens 59-68 23741252-7 2012 Phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by IFN-gamma was also significantly inhibited by EGCG. epigallocatechin gallate 135-139 interferon gamma Homo sapiens 89-98 23741252-8 2012 Reporter assays indicated that EGCG inhibited the transcriptional activities of IDO promoters, IFN-stimulated response element and IFN-gamma activation sequence, activated by STAT1 phosphorylation. epigallocatechin gallate 31-35 interferon gamma Homo sapiens 131-140 22677201-6 2012 IFN-gamma production was measured upon cell activation using PMA alone or in combination with ionomycin in order to assess functional capacities of the cells. Ionomycin 94-103 interferon gamma Homo sapiens 0-9 23028326-4 2012 Despite this difference, mangabey NKT lymphocytes were functionally distinct from both macaque species in their ability to secrete significantly more IFN-gamma, IL-13, and IL-17 in response to CD1d/alpha-galactosylceramide stimulation. alpha-galactosylceramide 198-222 interferon gamma Homo sapiens 150-159 23650606-2 2012 The interference of chloroquine with interferon-gamma-induced tryptophan breakdown and neopterin production has been investigated in human peripheral blood mononuclear cells (PBMC) in vitro. Chloroquine 20-31 interferon gamma Homo sapiens 37-53 23650606-2 2012 The interference of chloroquine with interferon-gamma-induced tryptophan breakdown and neopterin production has been investigated in human peripheral blood mononuclear cells (PBMC) in vitro. Tryptophan 62-72 interferon gamma Homo sapiens 37-53 22700860-8 2012 In serum, significant decreases in IL-6, IL-10, IL-12 p40, tumor necrosis factor-alpha, IFN-gamma, and IFN-gamma-induced protein-10 concentrations during prednisone, but not placebo, treatment were observed. Prednisone 154-164 interferon gamma Homo sapiens 88-97 22920436-6 2012 The mentioned Flu-MP* specific CD8+ T cells from chagasic patients were predominately TEM (CCR7- CD62L-), producing IL-2, IFNgamma, CD107a/b and perforin, and did not present significant differences when compared with those from healthy donors. flu-mp 14-20 interferon gamma Homo sapiens 122-130 22700860-8 2012 In serum, significant decreases in IL-6, IL-10, IL-12 p40, tumor necrosis factor-alpha, IFN-gamma, and IFN-gamma-induced protein-10 concentrations during prednisone, but not placebo, treatment were observed. Prednisone 154-164 interferon gamma Homo sapiens 103-112 22733812-2 2012 A reduction of IFN-gamma-producing CD4(+) T cells is observed in DMF-treated patients and may contribute to its clinical efficacy. Dimethyl Fumarate 65-68 interferon gamma Homo sapiens 15-24 22435970-9 2012 Levels of IFN-gamma (P<0.0001) after isotretinoin treatment were lower than those of the control group. Isotretinoin 40-52 interferon gamma Homo sapiens 10-19 22566116-11 2012 Ventilator, oxygen supplementation, and hospital days correlated with TA IFN-gamma levels (all p <= 0.01). Oxygen 12-18 interferon gamma Homo sapiens 73-82 22463716-5 2012 Pharmacological inhibition of MEK/ERK1/2 signalling with U0126 significantly inhibited IFNgamma-induced increases in the transcytosis of non-invasive Escherichia coli (strain HB101). U 0126 57-62 interferon gamma Homo sapiens 87-95 22314659-1 2012 BACKGROUND: This pilot study aimed to assess whether the perioperative infusion of donor bone marrow cells (DBMC) in renal allograft recipients can affect the appearance of peripheral regulatory T-cell subsets and the profile of cytokine-producing cells [interferon-gamma (IFN-gamma), interleukin (IL)-17 and IL-10] 2 years after transplantation. 4,6-Di-tert-butyl-m-cresol 108-112 interferon gamma Homo sapiens 255-271 22314659-1 2012 BACKGROUND: This pilot study aimed to assess whether the perioperative infusion of donor bone marrow cells (DBMC) in renal allograft recipients can affect the appearance of peripheral regulatory T-cell subsets and the profile of cytokine-producing cells [interferon-gamma (IFN-gamma), interleukin (IL)-17 and IL-10] 2 years after transplantation. 4,6-Di-tert-butyl-m-cresol 108-112 interferon gamma Homo sapiens 273-282 22314659-6 2012 Furthermore, the ratio of IL-10/IFN-gamma-producing cells was significantly higher in the DBMC-infused group versus controls (P = 0.01). 4,6-Di-tert-butyl-m-cresol 90-94 interferon gamma Homo sapiens 32-41 22435970-10 2012 CONCLUSIONS: This study shows that isotretinoin treatment significantly decreases TNF, IL-4, IL-17 and IFN-gamma levels in patients with acne. Isotretinoin 35-47 interferon gamma Homo sapiens 103-112 22805469-7 2012 RESULTS: Staphylococcal enterotoxin B induced IL-5, IL-13, IL-17A and IFN-gamma production by DNPCs. dnpcs 94-99 interferon gamma Homo sapiens 70-79 22752353-5 2012 However, the serum levels of interferon-gamma among the patients in the AFBN group were significantly higher than those among the patients in the control group. afbn 72-76 interferon gamma Homo sapiens 29-45 22774993-7 2012 Lenalidomide at 30-1000 nM significantly enhanced chemotaxis to S1P and IL-2 generation for T cells from HIV-negative CD4 T lymphocytopenic patients as from HIV-infected patients, with less effect on CCL21-elicited chemotaxis and none for IFN-gamma generation. Lenalidomide 0-12 interferon gamma Homo sapiens 239-248 22805469-11 2012 LPS pre-treatment enhanced SEB-induced IL-5, IL-13 and IL-17A production in diclofenac-treated DNPCs, while addition of PGE(2) inhibited IL-5, IL-13 and IFN-gamma production. Prostaglandins E 120-123 interferon gamma Homo sapiens 154-163 22805469-12 2012 LPS alone induced IL-5, IL-13 and IFN- gamma production by diclofenac-treated DNPCs, while the addition of EP2 and EP4 receptor-selective agonists, as well as PGE(2) itself, inhibited IL-5 and IL-13 production. Diclofenac 59-69 interferon gamma Homo sapiens 34-44 22805469-12 2012 LPS alone induced IL-5, IL-13 and IFN- gamma production by diclofenac-treated DNPCs, while the addition of EP2 and EP4 receptor-selective agonists, as well as PGE(2) itself, inhibited IL-5 and IL-13 production. dnpcs 78-83 interferon gamma Homo sapiens 34-44 22583692-7 2012 Logistic regression analysis demonstrated a significant positive association between PTU and high levels of IFN-gamma, IL-8, MIG and IP-10. ptu 85-88 interferon gamma Homo sapiens 108-117 22562770-4 2012 OBJECTIVES: In this study we sought to elucidate the relationship between maternal PAH exposure and promoter methylation status of IFNgamma and IL4. Polycyclic Aromatic Hydrocarbons 83-86 interferon gamma Homo sapiens 131-139 22562770-5 2012 METHODS: We assessed the effects of benzo[a]pyrene (BaP), a representative airborne PAH, on the methylation status of the IFNgamma and IL4 promoters in Jurkat cells and two lung adenocarcinoma cell lines, and on gene expression. Benzo(a)pyrene 36-50 interferon gamma Homo sapiens 122-130 22562770-5 2012 METHODS: We assessed the effects of benzo[a]pyrene (BaP), a representative airborne PAH, on the methylation status of the IFNgamma and IL4 promoters in Jurkat cells and two lung adenocarcinoma cell lines, and on gene expression. Benzo(a)pyrene 52-55 interferon gamma Homo sapiens 122-130 22562770-5 2012 METHODS: We assessed the effects of benzo[a]pyrene (BaP), a representative airborne PAH, on the methylation status of the IFNgamma and IL4 promoters in Jurkat cells and two lung adenocarcinoma cell lines, and on gene expression. Polycyclic Aromatic Hydrocarbons 84-87 interferon gamma Homo sapiens 122-130 22562770-8 2012 RESULTS: In vitro exposure of the cell models to low, noncytotoxic doses (0.1 and 1 nM) of BaP elicited increased promoter hypermethylation and reduced expression of IFNgamma, but not IL4. Benzo(a)pyrene 91-94 interferon gamma Homo sapiens 166-174 22562770-9 2012 IFNgamma promoter methylation in cord white blood cells was associated with maternal PAH exposure in the cohort study subsample. Polycyclic Aromatic Hydrocarbons 85-88 interferon gamma Homo sapiens 0-8 22268679-0 2012 Clozapine inhibits Th1 cell differentiation and causes the suppression of IFN-gamma production in peripheral blood mononuclear cells. Clozapine 0-9 interferon gamma Homo sapiens 74-83 22268679-4 2012 We examined the effects of risperidone, clozapine, and haloperidol on the production of phorbol myristate acetate and ionomycin-induced interferon-gamma (IFN-gamma)/interleukin (IL)-4 in PBMCs by using intracellular staining. Risperidone 27-38 interferon gamma Homo sapiens 136-152 22268679-4 2012 We examined the effects of risperidone, clozapine, and haloperidol on the production of phorbol myristate acetate and ionomycin-induced interferon-gamma (IFN-gamma)/interleukin (IL)-4 in PBMCs by using intracellular staining. Ionomycin 118-127 interferon gamma Homo sapiens 136-152 22268679-4 2012 We examined the effects of risperidone, clozapine, and haloperidol on the production of phorbol myristate acetate and ionomycin-induced interferon-gamma (IFN-gamma)/interleukin (IL)-4 in PBMCs by using intracellular staining. Risperidone 27-38 interferon gamma Homo sapiens 154-163 22268679-4 2012 We examined the effects of risperidone, clozapine, and haloperidol on the production of phorbol myristate acetate and ionomycin-induced interferon-gamma (IFN-gamma)/interleukin (IL)-4 in PBMCs by using intracellular staining. Ionomycin 118-127 interferon gamma Homo sapiens 154-163 22268679-4 2012 We examined the effects of risperidone, clozapine, and haloperidol on the production of phorbol myristate acetate and ionomycin-induced interferon-gamma (IFN-gamma)/interleukin (IL)-4 in PBMCs by using intracellular staining. Clozapine 40-49 interferon gamma Homo sapiens 136-152 22268679-6 2012 Our results indicated that clozapine can suppress the stimulated production of IFN-gamma by 30.62%, whereas haloperidol weakly enhances the expression of IFN-gamma. Clozapine 27-36 interferon gamma Homo sapiens 79-88 22268679-6 2012 Our results indicated that clozapine can suppress the stimulated production of IFN-gamma by 30.62%, whereas haloperidol weakly enhances the expression of IFN-gamma. Haloperidol 108-119 interferon gamma Homo sapiens 154-163 22268679-4 2012 We examined the effects of risperidone, clozapine, and haloperidol on the production of phorbol myristate acetate and ionomycin-induced interferon-gamma (IFN-gamma)/interleukin (IL)-4 in PBMCs by using intracellular staining. Clozapine 40-49 interferon gamma Homo sapiens 154-163 22268679-4 2012 We examined the effects of risperidone, clozapine, and haloperidol on the production of phorbol myristate acetate and ionomycin-induced interferon-gamma (IFN-gamma)/interleukin (IL)-4 in PBMCs by using intracellular staining. Haloperidol 55-66 interferon gamma Homo sapiens 136-152 22268679-4 2012 We examined the effects of risperidone, clozapine, and haloperidol on the production of phorbol myristate acetate and ionomycin-induced interferon-gamma (IFN-gamma)/interleukin (IL)-4 in PBMCs by using intracellular staining. Haloperidol 55-66 interferon gamma Homo sapiens 154-163 22614033-4 2012 During IFN-gamma-induced inflammation, adhesion and transendothelial migration of THP-1 monocytes were enhanced, and the levels of GnT-V and beta(1,6)-linked GlcNAc in THP-1 monocytes were significantly decreased. beta(1,6)-linked glcnac 141-164 interferon gamma Homo sapiens 7-16 22585454-10 2012 CONCLUSION: Chemoprophylaxis with isoniazid and rifampicin generally decreased IFN-gamma levels among tuberculosis contacts. Isoniazid 34-43 interferon gamma Homo sapiens 79-88 22585454-10 2012 CONCLUSION: Chemoprophylaxis with isoniazid and rifampicin generally decreased IFN-gamma levels among tuberculosis contacts. Rifampin 48-58 interferon gamma Homo sapiens 79-88 22595141-6 2012 This new endocytosis motif, YxxLI, shares characteristics of tyrosine-based and dileucine-based internalization motifs and is highly conserved in IFN-gamma Rs across species. Tyrosine 61-69 interferon gamma Homo sapiens 146-155 22595141-6 2012 This new endocytosis motif, YxxLI, shares characteristics of tyrosine-based and dileucine-based internalization motifs and is highly conserved in IFN-gamma Rs across species. dileucine 80-89 interferon gamma Homo sapiens 146-155 22421108-6 2012 Stimulation of isolated CD8+ memory T cells, but not naive T cells, from HCL volunteers induced a significantly higher IFN-gamma production compared with that of healthy controls. Hydrochloric Acid 73-76 interferon gamma Homo sapiens 119-128 22170858-3 2012 The triterpene acid mixture inhibited the production of tumor necrosis factor-alpha and IL-6 with estimated IC50 values in the range 35-56 microg/mL, the Th1 cytokines interferon-gamma and IL-2 (IC50 values 10-20 microg/mL) and the antiinflammatory cytokine IL-10 (IC50 values 18-21 microg/mL). triterpene acid 4-19 interferon gamma Homo sapiens 168-184 22899436-4 2012 The cytokine expression in recovered animals was almost similar to that of vaccinated ones, where a unique biphasic response of IL-4 expression was observed with an up-regulation of IFN-gamma on 7(th) days post vaccination (dpv). diperoxovanadate 224-227 interferon gamma Homo sapiens 182-191 22898277-1 2012 OBJECTIVE: To measure levels of interleukin-4 (IL-4) and interferon-gamma (INF-gamma) in the bronchoalveolar lavage fluid (BALF) of children with refractory Mycoplasma pneumoniae pneumonia (RMPP), and to investigate changes in local Th1-Th2-type cytokine levels in children with RMPP and their significance. rmpp 190-194 interferon gamma Homo sapiens 57-84 22898277-5 2012 RESULTS: Compared with the control group, the total number of cells in BALF from children with RMPP increased significantly (P<0.05), the increase mainly accounted for by neutrophils (P<0.01), and levels of IL-4 and INF-gamma in BALF from children with RMPP increased significantly (P<0.05). rmpp 95-99 interferon gamma Homo sapiens 222-231 22898277-9 2012 CONCLUSIONS: Significant increase in cell numbers, especially neutrophils, as well as IL-4 and INF-gamma levels, can be seen in BALF from children with RMPP, but there is no change to the INF-gamma/IL-4 ratio. rmpp 152-156 interferon gamma Homo sapiens 95-104 22826629-12 2012 Lamivudine pretreatment significantly reduced IFN-gamma + TNF-alpha-mediated toxicity of HepG2.2.15 cells [85.82% +- 5.43% (sequential) vs 58.03% +- 8.03% (cytokine), P = 0.002]. Lamivudine 0-10 interferon gamma Homo sapiens 46-55 22610351-9 2012 In vitro, Fas-mediated apoptosis was enhanced by CD40 stimulation and IFN-gamma in endothelial cells and by CD40 stimulation in epithelial cells. ammonium ferrous sulfate 10-13 interferon gamma Homo sapiens 70-79 22159472-5 2012 Prior to surgery, the patients demonstrated Treg-mediated suppression of TNFalpha and IFNgamma expression that could be perturbed through the PGE(2)/cAMP pathway and the immune suppression was significantly higher in the group that later developed disease recurrence (P = 0.046). treg 44-48 interferon gamma Homo sapiens 86-94 22731727-5 2012 CBA revealed a Th1 cytokine profile featuring increased IFN-gamma, TNF-alpha, and IL-1beta levels. cba 0-3 interferon gamma Homo sapiens 56-65 22159472-5 2012 Prior to surgery, the patients demonstrated Treg-mediated suppression of TNFalpha and IFNgamma expression that could be perturbed through the PGE(2)/cAMP pathway and the immune suppression was significantly higher in the group that later developed disease recurrence (P = 0.046). Prostaglandins E 142-145 interferon gamma Homo sapiens 86-94 22159472-5 2012 Prior to surgery, the patients demonstrated Treg-mediated suppression of TNFalpha and IFNgamma expression that could be perturbed through the PGE(2)/cAMP pathway and the immune suppression was significantly higher in the group that later developed disease recurrence (P = 0.046). Cyclic AMP 149-153 interferon gamma Homo sapiens 86-94 22437006-4 2012 However, both HKVC and the LPS showed a substantial induction of IL-8 production in IFN-gamma-primed HT-29 cells. hkvc 14-18 interferon gamma Homo sapiens 84-93 22183480-5 2012 Stimulation with mKatG resulted in higher simultaneous IFN-gamma and TNF production, but less single IFN-gamma production, from total BAL fluid CD4+ T-cells of Lofgren"s syndrome patients, when compared with non-Lofgren"s patients. mkatg 17-22 interferon gamma Homo sapiens 55-64 22183480-5 2012 Stimulation with mKatG resulted in higher simultaneous IFN-gamma and TNF production, but less single IFN-gamma production, from total BAL fluid CD4+ T-cells of Lofgren"s syndrome patients, when compared with non-Lofgren"s patients. mkatg 17-22 interferon gamma Homo sapiens 101-110 22183480-7 2012 Furthermore, mKatG stimulated higher IFN-gamma production in BAL fluid and blood AV2S3+ T-cells than AV2S3- T-cells, whereas the opposite was seen in BAL fluid with PPD stimulation. mkatg 13-18 interferon gamma Homo sapiens 37-46 22585464-5 2012 In correlation with cytokine levels in serum, RA regulated the production of IFN-gamma and IL-4 but not TNF-alpha by NKT cells without influencing the NKT-cell activation status. Tretinoin 46-48 interferon gamma Homo sapiens 77-86 22796839-0 2012 Challenges of interferon-gamma release assay conversions in serial testing of health-care workers in a TB control program. Terbium 103-105 interferon gamma Homo sapiens 14-30 22585464-6 2012 However, RA did not alleviate alpha-GalCer-induced liver injury, even though it reduced IFN-gamma and IL-4 but not TNF-alpha levels in serum. Tretinoin 9-11 interferon gamma Homo sapiens 88-97 22209114-8 2012 In an allogeneic mixed lymphocyte reaction, the proportion of IFN-gamma+CD4+ T cells was decreased (26% vs. 51%, p=0.005) when T cells were stimulated with DCs exposed to VPA. Valproic Acid 171-174 interferon gamma Homo sapiens 62-71 21482445-0 2012 Interferon-gamma plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways. Paraquat 33-41 interferon gamma Homo sapiens 0-16 22526675-5 2012 The data showed that IFN-gamma-mediated Stat-1 tyrosine phosphorylation was inhibited by EHEC secreted proteins. Tyrosine 47-55 interferon gamma Homo sapiens 21-30 22526675-8 2012 We conclude that while other factors are likely involved in the suppression of IFN-gamma-mediated Stat-1 tyrosine phosphorylation, E. coli-derived Shiga toxins represent a novel mechanism by which EHEC evades the host immune system. Tyrosine 105-113 interferon gamma Homo sapiens 79-88 22247115-14 2012 Birds supplemented with combined probiotics and organic acids for 7 d showing similar responses in TLR-2, IL-12p35, and IFN-gamma compared with those supplemented for 14 d indicates that shorter periods of supplementation might be enough to elicit beneficial responses. organic acids 48-61 interferon gamma Homo sapiens 120-129 22743898-10 2012 Silicone microparticles at 100 mug/ml, however, significantly induced the production and gene expression of TNF-alpha, IL-6, and IFN-gamma by peripheral blood mononuclear cells. Silicones 0-8 interferon gamma Homo sapiens 129-138 21482445-4 2012 Indeed, the present investigation demonstrated that genetic deletion of IFN-gamma protected substantia nigra pars compacta (SNc) dopamine (DA) neurons from the toxic effects of the pesticide, paraquat, and normalized changes in inflammatory and oxidative factors within this brain region. Dopamine 129-137 interferon gamma Homo sapiens 72-81 21482445-4 2012 Indeed, the present investigation demonstrated that genetic deletion of IFN-gamma protected substantia nigra pars compacta (SNc) dopamine (DA) neurons from the toxic effects of the pesticide, paraquat, and normalized changes in inflammatory and oxidative factors within this brain region. Dopamine 139-141 interferon gamma Homo sapiens 72-81 21482445-4 2012 Indeed, the present investigation demonstrated that genetic deletion of IFN-gamma protected substantia nigra pars compacta (SNc) dopamine (DA) neurons from the toxic effects of the pesticide, paraquat, and normalized changes in inflammatory and oxidative factors within this brain region. Paraquat 192-200 interferon gamma Homo sapiens 72-81 21482445-7 2012 These data suggest that IFN-gamma is important for paraquat-induced neurodegeneration and the accompanying oxidative, inflammatory, and trophic changes that characterize the response to the toxin. Paraquat 51-59 interferon gamma Homo sapiens 24-33 22734718-8 2012 RESULTS: Confocal imaging of primary cultures of WT and IF-deficient astrocytes revealed IFN-gamma induced MHC class II expression in late endosomes/lysosomes, which were specifically labeled with Alexa Fluor546-conjugated dextran. Alexa fluor 546 197-211 interferon gamma Homo sapiens 89-98 23019942-9 2012 Compared with the FQD group and the normal control group, a higher serum level of TNF-alpha and a lower level of IFN-gamma were found in the SYD group and the YDFE group (P < 0.05). ydfe 159-163 interferon gamma Homo sapiens 113-122 22734718-8 2012 RESULTS: Confocal imaging of primary cultures of WT and IF-deficient astrocytes revealed IFN-gamma induced MHC class II expression in late endosomes/lysosomes, which were specifically labeled with Alexa Fluor546-conjugated dextran. Dextrans 223-230 interferon gamma Homo sapiens 89-98 22734718-9 2012 Live imaging revealed faster movement of dextran-positive vesicles in IFN-gamma-treated than in untreated astrocytes. Dextrans 41-48 interferon gamma Homo sapiens 70-79 22581042-6 2012 In particular for IFN-gamma, a significant modulatory effect on the intracellular reactive oxygen species production and phagocytic activity was observed. Reactive Oxygen Species 82-105 interferon gamma Homo sapiens 18-27 23019942-15 2012 The serum IFN-gamma was positively correlated with urinary 17-OH (r = 0.21, P = 0.03). 17-oh 59-64 interferon gamma Homo sapiens 10-19 22517765-8 2012 Butyrate effectively inhibited IFN-gamma-induced STAT1 activation, resulting in inhibition of iNOS upregulation in human colon epithelial and carcinoma cells in vitro. Butyrates 0-8 interferon gamma Homo sapiens 31-40 22944136-12 2012 The levels of IFN-gamma spot-forming T cells were higher in the E7PA + CpG group than the control group with statistic significance (P < 0.01). e7pa 64-68 interferon gamma Homo sapiens 14-23 22944136-13 2012 In terms of specificity, E7PA + CpG in the HPV18 positive group could induce the proliferation of IFN-gamma-secreting T cells. e7pa 25-29 interferon gamma Homo sapiens 98-107 22517765-9 2012 Our data thus suggest that butyrate delivers a double-hit: induction of T cell apoptosis to eliminate the source of inflammation and suppression of IFN-gamma-mediated inflammation in colonic epithelial cells, to suppress colonic inflammation. Butyrates 27-35 interferon gamma Homo sapiens 148-157 22581860-4 2012 Keratinocytes loaded with alpha-galactosyl ceramide (alpha-GalCer) could stimulate IFN-gamma production and CD25 upregulation by iNKT cells. alpha-galactosylceramide 26-51 interferon gamma Homo sapiens 83-92 22581860-4 2012 Keratinocytes loaded with alpha-galactosyl ceramide (alpha-GalCer) could stimulate IFN-gamma production and CD25 upregulation by iNKT cells. alpha-galactosylceramide 53-65 interferon gamma Homo sapiens 83-92 22147632-0 2012 The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-gamma and interleukin-17 production by human CD4+ T cells. tofacitinib 18-29 interferon gamma Homo sapiens 72-88 24710421-3 2012 Fourteen patients with confirmed LNB and 103 patients with non-LNB were included, and the numbers of spontaneous and Bb-induced IFN-gamma-secreting cells were assayed by the ELISPOT test. boeravinone B 117-119 interferon gamma Homo sapiens 128-137 22641665-10 2012 Furthermore, it has been shown that treatment strategies combining the HSP inhibitor KNK437 or interferon-gamma (IFN-gamma) with gemcitabine, were effective in gemcitabine-resistant pancreatic cancer cells in vitro. gemcitabine 129-140 interferon gamma Homo sapiens 113-122 22641665-10 2012 Furthermore, it has been shown that treatment strategies combining the HSP inhibitor KNK437 or interferon-gamma (IFN-gamma) with gemcitabine, were effective in gemcitabine-resistant pancreatic cancer cells in vitro. gemcitabine 160-171 interferon gamma Homo sapiens 95-111 22641665-10 2012 Furthermore, it has been shown that treatment strategies combining the HSP inhibitor KNK437 or interferon-gamma (IFN-gamma) with gemcitabine, were effective in gemcitabine-resistant pancreatic cancer cells in vitro. gemcitabine 160-171 interferon gamma Homo sapiens 113-122 22116680-6 2012 It was concluded that dietary vanadium in excess of 30 mg/kg reduced the ileac T cell population and percentages of T cell subsets, and IL-2, IL-6, and IFN-gamma contents, implying that the immune function of local intestinal mucosa in broilers could be affected by the dietary vanadium. Vanadium 30-38 interferon gamma Homo sapiens 152-161 22147632-5 2012 RESULTS: Tofacitinib treatment of CD4+ T cells originating from synovium and peripheral blood inhibited the production of interleukin-17 (IL-17) and interferon-gamma (IFNgamma) in a dose-dependent manner, affecting both proliferation and transcription, but had no effect on IL-6 and IL-8 production. tofacitinib 9-20 interferon gamma Homo sapiens 149-165 22147632-5 2012 RESULTS: Tofacitinib treatment of CD4+ T cells originating from synovium and peripheral blood inhibited the production of interleukin-17 (IL-17) and interferon-gamma (IFNgamma) in a dose-dependent manner, affecting both proliferation and transcription, but had no effect on IL-6 and IL-8 production. tofacitinib 9-20 interferon gamma Homo sapiens 167-175 22440610-4 2012 IFN-gamma up-regulation was also inhibited by SP600125, indicating that it was downstream of JNK activation. pyrazolanthrone 46-54 interferon gamma Homo sapiens 0-9 21748522-4 2012 Antiviral treatment with Telbivudine significantly increased IFN-gamma production by iNKT cells, which may be associated with the decreased PD-1 expression as manifested by blocking experiments. Telbivudine 25-36 interferon gamma Homo sapiens 61-70 22757586-0 2012 Mathematical modelling unravels regulatory mechanisms of interferon-gamma-induced STAT1 serine-phosphorylation and MUC4 expression in pancreatic cancer cells. Serine 88-94 interferon gamma Homo sapiens 57-73 22112438-8 2012 The C6-mediated increase of IFN-gamma production and IFN-gamma expressing CD4(+) T cell populations were significantly suppressed by a COX-2 specific inhibitor (NS-398) in a dose-dependent manner. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 161-167 interferon gamma Homo sapiens 28-37 22112438-8 2012 The C6-mediated increase of IFN-gamma production and IFN-gamma expressing CD4(+) T cell populations were significantly suppressed by a COX-2 specific inhibitor (NS-398) in a dose-dependent manner. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 161-167 interferon gamma Homo sapiens 53-62 22757586-3 2012 Experimental data indicate that reaction steps involved in IFN-gamma induced serine-phosphorylation of STAT1 vary between cell types in contrast to conserved IFN-gamma induced tyrosine-phosphorylation of STAT1. Tyrosine 176-184 interferon gamma Homo sapiens 158-167 22757586-3 2012 Experimental data indicate that reaction steps involved in IFN-gamma induced serine-phosphorylation of STAT1 vary between cell types in contrast to conserved IFN-gamma induced tyrosine-phosphorylation of STAT1. Serine 77-83 interferon gamma Homo sapiens 59-68 22757586-4 2012 The above observations raise the following two questions: (i) How does IFNgamma stimulation regulates serine-phosphorylation of STAT1 in the pancreatic cancer cell line CD18/HPAF? Serine 102-108 interferon gamma Homo sapiens 71-79 21340508-6 2012 In addition, we found that isoxanthohumol blocked IFN-gamma, IL-4 and IL-6 dependent Jak/Stat signaling and strongly inhibited the induction of pro-inflammatory genes in MonoMac6 cells at the transcriptional level after LPS/TPA treatment. isoxanthohumol 27-41 interferon gamma Homo sapiens 50-59 22735798-0 2012 Natural oils enhance IL-10 and IFN-gamma production by human PBMCs cultured with Malassezia furfur. natural oils 0-12 interferon gamma Homo sapiens 31-40 22381458-6 2012 RESULTS: The levels of TB antigen specific IFN-gamma and IP-10 were significantly higher in HHC compared to HC. Terbium 23-25 interferon gamma Homo sapiens 43-52 22416258-11 2012 Taken together, the present findings suggest that analysis of the expansion of CD4(+)IFN-gamma(+)IL-17(+) T lymphocytes in peripheral blood of TB patients might be used as an indicator of the clinical outcome in active TB. Terbium 143-145 interferon gamma Homo sapiens 85-94 22489793-1 2012 The aim of the current study is to situate CDs expression (CD3+, CD4+, CD8+) and their relationship with IFNgamma and NO production in Algerian patients with Behcet disease (n = 34 ). Cadmium 43-46 interferon gamma Homo sapiens 105-113 22546856-8 2012 Addition of GSH or N-acetylcysteine to PBMCs selectively restored IL-12 and IFN-gamma production and improved bacterial killing. Glutathione 12-15 interferon gamma Homo sapiens 88-97 22546856-8 2012 Addition of GSH or N-acetylcysteine to PBMCs selectively restored IL-12 and IFN-gamma production and improved bacterial killing. Acetylcysteine 19-35 interferon gamma Homo sapiens 88-97 22424783-6 2012 The synergism in effect of zebularine and IFN-gamma on IDO1 expression is paralleled by a similar synergistic effect on expression of two other IFN-gamma-responsive genes, the transcription factors STAT1 and IRF1 with binding sites in the IDO1 promoter region. pyrimidin-2-one beta-ribofuranoside 27-37 interferon gamma Homo sapiens 144-153 22434859-2 2012 Compound IQ-1 (11H-indeno[1,2-b]quinoxalin-11-one oxime) was found to be a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, interferon-gamma, and granulocyte-macrophage colony-stimulating factor] and nitric oxide production by human and murine monocyte/macrophages. 11H-indeno(1,2-b)quinoxalin-11-one oxime 15-55 interferon gamma Homo sapiens 219-290 22647055-10 2012 RESULTS: DSS-induced acute colitis model was characterized by a reduced BW, AUC of BW, serum calcium, higher DAI, AUC of DAI, shortened colon length, elevated MPO activity, worsened histologic inflammation, increased mononuclear cell numbers in mesenteric lymph nodes (MLNs) and colonic lamina propria (LP), and enhanced proteins and mRNA levels of TNF-alpha and IFN-gamma. Dextran Sulfate 9-12 interferon gamma Homo sapiens 363-372 22647614-0 2012 The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-gamma. Vorinostat 34-65 interferon gamma Homo sapiens 118-134 22647614-5 2012 RESULTS: SAHA significantly attenuated the toxicity of astrocytes activated by IFN-gamma towards SH-SY5Y human neuronal cells. Vorinostat 9-13 interferon gamma Homo sapiens 79-88 22647614-6 2012 In the IFN-gamma-activated astrocytes, SAHA reduced the STAT3 phosphorylation. Vorinostat 39-43 interferon gamma Homo sapiens 7-16 22647614-7 2012 SAHA also inhibited the IFN-gamma-induced astrocytic production of I-TAC, but not ICAM-1. Vorinostat 0-4 interferon gamma Homo sapiens 24-33 22647614-8 2012 These results indicate that SAHA suppresses IFN-gamma-induced neurotoxicity of human astrocytes through inhibition of the STAT3 signaling pathway. Vorinostat 28-32 interferon gamma Homo sapiens 44-53 22883203-7 2012 In TLR4 non-blocking groups the expressions of hTNF-alpha and hIFN-gamma were rBCG group > wBCG group > hIFN-alpha-2b group > PBS group, the expressions of hIL-12 was hIFN-alpha-2b group > PBS group > rBCG group > wBCG group (all P < 0.05). pbs 201-204 interferon gamma Homo sapiens 62-72 22883203-7 2012 In TLR4 non-blocking groups the expressions of hTNF-alpha and hIFN-gamma were rBCG group > wBCG group > hIFN-alpha-2b group > PBS group, the expressions of hIL-12 was hIFN-alpha-2b group > PBS group > rBCG group > wBCG group (all P < 0.05). rbcg 78-82 interferon gamma Homo sapiens 62-72 22883203-7 2012 In TLR4 non-blocking groups the expressions of hTNF-alpha and hIFN-gamma were rBCG group > wBCG group > hIFN-alpha-2b group > PBS group, the expressions of hIL-12 was hIFN-alpha-2b group > PBS group > rBCG group > wBCG group (all P < 0.05). wbcg 94-98 interferon gamma Homo sapiens 62-72 22446936-7 2012 Hyperglycemia of streptozotocin-induced diabetic mice receiving 200 syngeneic islets into the liver from a single donor was ameliorated with down-regulation of IFN-gamma production of natural killer T cells and neutrophils in the liver when ATIII but not vehicle was administered once at the time of islet transplantation. Streptozocin 17-31 interferon gamma Homo sapiens 160-169 22625224-7 2012 The Bz-treatment lead to an overall cytokine down-regulation in the innate and adaptive compartments, including low levels of IL-12+ and IL-10+ neutrophils and monocytes, IFN-gamma+NK-cells, IL-12+, TNF-alpha+, IFN-gamma+ and IL-5+CD4+T-cells and IL-10+B-cells, along with basal levels of cytokine-expressing CD8+T-cells in INDt as compared to IND. benzonidazole 4-6 interferon gamma Homo sapiens 171-180 22403157-9 2012 Pulmonary exposure to 4-OPA caused a significant elevation in nonspecific airway hyperreactivity, increased numbers of lung-associated lymphocytes and neutrophils, and increased interferon-gamma production by lung-associated lymph nodes. 4-oxopentanal 22-27 interferon gamma Homo sapiens 178-194 22324848-7 2012 All of the analogues were found to stimulate murine and human iNKT cells by CD1d-mediated presentation to varying degrees; however, the thioamide and carbamate analogues of ThrCer were of particular interest in that they elicited a strongly polarized cytokine response (more interferon-gamma (IFN-gamma), no interleukin-4 (IL-4)) in mice. thrcer 173-179 interferon gamma Homo sapiens 275-291 22324848-7 2012 All of the analogues were found to stimulate murine and human iNKT cells by CD1d-mediated presentation to varying degrees; however, the thioamide and carbamate analogues of ThrCer were of particular interest in that they elicited a strongly polarized cytokine response (more interferon-gamma (IFN-gamma), no interleukin-4 (IL-4)) in mice. thrcer 173-179 interferon gamma Homo sapiens 293-302 22524620-0 2012 IFN-gamma induction on carbohydrate binding module of fungal immunomodulatory protein in human peripheral mononuclear cells. Carbohydrates 23-35 interferon gamma Homo sapiens 0-9 22524620-6 2012 Treatments of hPBMCs with tunicamycin and deglycosylation enzymes that removed the carbohydrate moieties reduced the secretion of IFN-gamma induction from hPBMCs. Tunicamycin 26-37 interferon gamma Homo sapiens 130-139 22524620-6 2012 Treatments of hPBMCs with tunicamycin and deglycosylation enzymes that removed the carbohydrate moieties reduced the secretion of IFN-gamma induction from hPBMCs. Carbohydrates 83-95 interferon gamma Homo sapiens 130-139 22625224-7 2012 The Bz-treatment lead to an overall cytokine down-regulation in the innate and adaptive compartments, including low levels of IL-12+ and IL-10+ neutrophils and monocytes, IFN-gamma+NK-cells, IL-12+, TNF-alpha+, IFN-gamma+ and IL-5+CD4+T-cells and IL-10+B-cells, along with basal levels of cytokine-expressing CD8+T-cells in INDt as compared to IND. benzonidazole 4-6 interferon gamma Homo sapiens 211-220 22504645-1 2012 Diagnosis of tuberculosis often relies on the ex vivo IFN-gamma release assays QuantiFERON-TB Gold In-Tube and T-SPOT.TB. tb gold 91-98 interferon gamma Homo sapiens 54-63 22504645-1 2012 Diagnosis of tuberculosis often relies on the ex vivo IFN-gamma release assays QuantiFERON-TB Gold In-Tube and T-SPOT.TB. Terbium 91-93 interferon gamma Homo sapiens 54-63 22386518-4 2012 Vaccination with VLP and alpha-galactosylceramide activated splenic iNKT cells to produce IFN-gamma and IL-4, led to the generation of antigen-specific T cells that protected prophylactically against subcutaneous tumor challenge, and was more effective at generating anti-tumor immune responses than either component individually. alpha-galactosylceramide 25-49 interferon gamma Homo sapiens 90-99 22617451-5 2012 Furthermore, IFN-gamma induced pOC fusion even in hydroxyapatite-coated plates used as a substitute for bone. Durapatite 50-64 interferon gamma Homo sapiens 13-22 22231731-16 2012 Iloprost-treated mDCs inhibited IL-13, IFN-gamma and IL-10 production by T cells. Iloprost 0-8 interferon gamma Homo sapiens 39-48 22510296-7 2012 In conclusion, atorvastatin can enhance IFN-gamma sensitivity in NSCLCs both in vitro and in vivo, probably through induction of a synergistic inhibitory effect on RhoA activity. Atorvastatin 15-27 interferon gamma Homo sapiens 40-49 22644861-4 2012 TSA suppressed the synthesis of the T cell-activating cytokine, interleukin (IL)-2, and the T cell-derived cytokines, interferon (IFN)-gamma, IL-4, and IL-13. trichostatin A 0-3 interferon gamma Homo sapiens 118-140 22325340-6 2012 Although no significant difference was observed between the groups of individuals studied, we found that most patients with IND displayed high levels of IFN-gamma gene expression, while the majority of patients with CARD 1 presented high levels of IL-10. indole 124-127 interferon gamma Homo sapiens 153-162 22698927-4 2012 We demonstrate that butyrate substantially down-regulates the expression of CD80, CD83, and MHC class II molecules; increases endocytic capability; reduces allostimulatory abilities; promote interleukin-10 (IL-10) production; and inhibits interleukin-12 (IL-12) and interferon-gamma (IFN-gamma) production. Butyrates 20-28 interferon gamma Homo sapiens 266-282 22698927-4 2012 We demonstrate that butyrate substantially down-regulates the expression of CD80, CD83, and MHC class II molecules; increases endocytic capability; reduces allostimulatory abilities; promote interleukin-10 (IL-10) production; and inhibits interleukin-12 (IL-12) and interferon-gamma (IFN-gamma) production. Butyrates 20-28 interferon gamma Homo sapiens 284-293 22551544-7 2012 RESULTS: Treatment of mice with BiLu resulted in a dosedependent transient decrease in CD3+ T cells (both CD4+ and CD8+) that returned to the normal range within 48 h. Catumaxomab physiologically activated T cells in vitro (increased CD69 expression) and induced cytokine release (TNFalpha, IFNgamma). bilu 32-36 interferon gamma Homo sapiens 291-299 22969967-0 2012 Interferon-gamma enhances promyelocytic leukemia protein expression in acute promyelocytic cells and cooperates with all-trans-retinoic acid to induce maturation of NB4 and NB4-R1 cells. Tretinoin 117-140 interferon gamma Homo sapiens 0-16 22305546-0 2012 Cellular interferon-gamma and interleukin-13 immune reactivity in type 1, type 2 and latent autoimmune diabetes: action LADA 6. lada 6 120-126 interferon gamma Homo sapiens 9-25 22969967-7 2012 The results of the NBT reduction test and CD11b antigen detection by FCM indicated that IFN-gamma induces the differentiation of NB4 and NB4-R1 cells to some extent. Nitroblue Tetrazolium 19-22 interferon gamma Homo sapiens 88-97 22969967-11 2012 IFN-gamma in combination with ATRA not only strengthens the induction differentiation effect of ATRA on NB4 cells, but also can partially induce the maturation of NB4-R1 cells with ATRA resistance. Tretinoin 96-100 interferon gamma Homo sapiens 0-9 22969967-11 2012 IFN-gamma in combination with ATRA not only strengthens the induction differentiation effect of ATRA on NB4 cells, but also can partially induce the maturation of NB4-R1 cells with ATRA resistance. Tretinoin 96-100 interferon gamma Homo sapiens 0-9 22969967-10 2012 Together, IFN-gamma augments the proliferation inhibition effect of ATRA on NB4 and NB4-R1 cells through enhancing the expression of PML protein. Tretinoin 68-72 interferon gamma Homo sapiens 10-19 22410149-8 2012 AZM exerted a dose-dependent inhibition of IFN-gamma and TNF-alpha production from NK-92 cells, but did not affect the cytokine production of IL-15 activated primary NK cells. Azithromycin 0-3 interferon gamma Homo sapiens 43-52 22304689-4 2012 Interferon-gamma augmented the surface expression of the NKG2D ligands, and this augmentation was significantly attenuated by histamine. Histamine 126-135 interferon gamma Homo sapiens 0-16 22507941-0 2012 TB screening in an HIV clinic: how interferon-gamma assays improve screening compliance. Terbium 0-2 interferon gamma Homo sapiens 35-51 22474018-9 2012 Finally, we confirmed that stimulation with IFN-gamma or TLR3 ligand (polyinosinic-polycytidylic acid) significantly induced both NK2R mRNA and surface protein expression of human PBMC-derived DCs, as well as enhanced human TAC1 mRNA, which encodes NKA and Substance P. Poly I-C 70-101 interferon gamma Homo sapiens 44-53 22934457-5 2012 RESULTS: Both PRs and SPs demonstrated significantly higher levels of IL-7, IL-10 and IFN-gamma than healthy controls (p < 0.05). Sodium phenolsulfonate 22-25 interferon gamma Homo sapiens 86-95 22323498-4 2012 In addition, cytotoxicity of doxorubicin can be enhanced by combining this drug with the cytokine interferon-gamma (IFNgamma). Doxorubicin 29-40 interferon gamma Homo sapiens 98-114 22469634-2 2012 In this paper, we used a new established NK cell line NKG cells as the responder to hIL-12 stimulation by detecting their IFN-gamma production. hil-12 84-90 interferon gamma Homo sapiens 122-131 22469634-3 2012 It was found that NKG cells produced high level of IFN-gamma when simulated by hIL-12, and the dose-response curve became the best Sigmoid curve (R(2)=0.9977, p<0.0001) when stimulated for 24h. hil-12 79-85 interferon gamma Homo sapiens 51-60 22469634-6 2012 Addition of the neutralizing anti-hIL-12 antibody to the bioassay significantly inhibited the IFN-gamma production in a dose dependent manner, indicating that the bioactivity was actually mediated by hIL-12. hil-12 34-40 interferon gamma Homo sapiens 94-103 22469634-6 2012 Addition of the neutralizing anti-hIL-12 antibody to the bioassay significantly inhibited the IFN-gamma production in a dose dependent manner, indicating that the bioactivity was actually mediated by hIL-12. hil-12 200-206 interferon gamma Homo sapiens 94-103 22469634-8 2012 In conclusion, a reliable hIL-12 bioassay for determining its biological activity was established by using NKG cells as a responder and measuring their production of IFN-gamma. hil-12 26-32 interferon gamma Homo sapiens 166-175 22323498-11 2012 In conclusion, we demonstrate that doxorubicin induces interferon-responsive genes via IFNgamma-JAK-STAT1 signaling and that this pathway is relevant for doxorubicin"s cytotoxicity in HeLa cells. Doxorubicin 35-46 interferon gamma Homo sapiens 87-95 22323498-11 2012 In conclusion, we demonstrate that doxorubicin induces interferon-responsive genes via IFNgamma-JAK-STAT1 signaling and that this pathway is relevant for doxorubicin"s cytotoxicity in HeLa cells. Doxorubicin 154-165 interferon gamma Homo sapiens 87-95 22323498-4 2012 In addition, cytotoxicity of doxorubicin can be enhanced by combining this drug with the cytokine interferon-gamma (IFNgamma). Doxorubicin 29-40 interferon gamma Homo sapiens 116-124 22323498-8 2012 An enhanced secretion of IFNgamma was observed when HeLa cells were exposed to doxorubicin compared with untreated cells. Doxorubicin 79-90 interferon gamma Homo sapiens 25-33 22458995-2 2012 These lower levels may be regarded as a biochemical marker for cellular immune activation, which may lead to increased catabolism of tryptophan into kynurenine via stimulation of the enzyme indoleamine 2,3-dioxygenase (IDO) by interferon-gamma. Tryptophan 133-143 interferon gamma Homo sapiens 227-243 22458995-2 2012 These lower levels may be regarded as a biochemical marker for cellular immune activation, which may lead to increased catabolism of tryptophan into kynurenine via stimulation of the enzyme indoleamine 2,3-dioxygenase (IDO) by interferon-gamma. Kynurenine 149-159 interferon gamma Homo sapiens 227-243 22537161-6 2012 IFN-gamma and RA could collaborate with nicotine in elevating the expression of MUC4, utilizing E2F1 and STAT1 transcription factors. Nicotine 40-48 interferon gamma Homo sapiens 0-9 22326899-8 2012 Formulations with AS01 elicited high frequencies of CD4(+) T cells producing IFN-gamma and IL-2. as01 18-22 interferon gamma Homo sapiens 77-86 22268118-5 2012 ASMC stimulation with IL-1beta, TNF-alpha, and IFNgamma (cytomix) induced the highest level of syndecan-4 shedding. asmc 0-4 interferon gamma Homo sapiens 47-55 24049643-5 2012 Apocynin inhibited the intracellular reactive oxygen species production by PMN (80%) and IFN gamma /TNF alpha -differentiated HL-60 cells (45%) but showed a minor effect in PBMC and DMSO differentiated HL-60 cells (20%). acetovanillone 0-8 interferon gamma Homo sapiens 89-98 22452815-12 2012 It is our view that signalling by cytokines such as IFNgamma is but a variation of specific gene activation by steroid hormones. Steroids 111-127 interferon gamma Homo sapiens 52-60 22504299-2 2012 However, the long-known IFN-gamma-dependent upregulation of human Trp-tRNA synthetase (TrpRS), a cytoplasmic enzyme that activates tryptophan to form Trp-AMP in the first step of protein synthesis, is unexplained. Tryptophan 131-141 interferon gamma Homo sapiens 24-33 22504299-2 2012 However, the long-known IFN-gamma-dependent upregulation of human Trp-tRNA synthetase (TrpRS), a cytoplasmic enzyme that activates tryptophan to form Trp-AMP in the first step of protein synthesis, is unexplained. tryptophanyl-5'-adenosine monophosphate 150-157 interferon gamma Homo sapiens 24-33 22504299-4 2012 The IFN-gamma-dependent poly(ADP-ribosyl)ation of DNA-PKcs (which activates its kinase function) and concomitant activation of the tumor suppressor p53 were specifically prevented by Trp-SA, an analog of Trp-AMP that disrupted the TrpRS-DNA-PKcs-PARP-1 complex. trp-sa 183-189 interferon gamma Homo sapiens 4-13 22504299-4 2012 The IFN-gamma-dependent poly(ADP-ribosyl)ation of DNA-PKcs (which activates its kinase function) and concomitant activation of the tumor suppressor p53 were specifically prevented by Trp-SA, an analog of Trp-AMP that disrupted the TrpRS-DNA-PKcs-PARP-1 complex. tryptophanyl-5'-adenosine monophosphate 204-211 interferon gamma Homo sapiens 4-13 22436237-9 2012 Using fluorescent detectors of reactive oxygen species and nitric oxide, dichlorofluorescein and diaminofluorescein, respectively, flow cytometry revealed that interleukin-1beta combined with interferon-gamma induced intracellular production of nitric oxide, which was associated with necrotic cell death in muscle cells. Reactive Oxygen Species 31-54 interferon gamma Homo sapiens 192-208 22460142-5 2012 In vitro experiments indicated that the effects of tofacitinib were mediated through suppression of interleukin 17 (IL-17) and interferon gamma production and proliferation of CD4 T cells, presumably Th1 and Th17. tofacitinib 51-62 interferon gamma Homo sapiens 127-143 21971587-5 2012 Interestingly, MDSC recovered from co-cultures without aATC showed potent ability to suppress activated T-cell-mediated cytotoxicity (P < 0.001), IFN-gamma production (P < 0.01) and T-cell proliferation (P < 0.05) compared to those recovered from aATC-containing co-cultures. aatc 55-59 interferon gamma Homo sapiens 149-158 22436237-9 2012 Using fluorescent detectors of reactive oxygen species and nitric oxide, dichlorofluorescein and diaminofluorescein, respectively, flow cytometry revealed that interleukin-1beta combined with interferon-gamma induced intracellular production of nitric oxide, which was associated with necrotic cell death in muscle cells. Nitric Oxide 59-71 interferon gamma Homo sapiens 192-208 22436237-9 2012 Using fluorescent detectors of reactive oxygen species and nitric oxide, dichlorofluorescein and diaminofluorescein, respectively, flow cytometry revealed that interleukin-1beta combined with interferon-gamma induced intracellular production of nitric oxide, which was associated with necrotic cell death in muscle cells. 2',7'-dichlorofluorescein 73-92 interferon gamma Homo sapiens 192-208 22436237-9 2012 Using fluorescent detectors of reactive oxygen species and nitric oxide, dichlorofluorescein and diaminofluorescein, respectively, flow cytometry revealed that interleukin-1beta combined with interferon-gamma induced intracellular production of nitric oxide, which was associated with necrotic cell death in muscle cells. diaminofluorescein 97-115 interferon gamma Homo sapiens 192-208 22436237-9 2012 Using fluorescent detectors of reactive oxygen species and nitric oxide, dichlorofluorescein and diaminofluorescein, respectively, flow cytometry revealed that interleukin-1beta combined with interferon-gamma induced intracellular production of nitric oxide, which was associated with necrotic cell death in muscle cells. Nitric Oxide 245-257 interferon gamma Homo sapiens 192-208 22436237-11 2012 Pharmacological inhibition of inducible nitric oxide synthase by 1400W reduced intracellular production of nitric oxide and prevented accumulation of beta-amyloid, nitration of tyrosine as well as cell death inflicted by interleukin-1beta combined with interferon-gamma. nitric 40-46 interferon gamma Homo sapiens 253-269 22436237-11 2012 Pharmacological inhibition of inducible nitric oxide synthase by 1400W reduced intracellular production of nitric oxide and prevented accumulation of beta-amyloid, nitration of tyrosine as well as cell death inflicted by interleukin-1beta combined with interferon-gamma. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 65-70 interferon gamma Homo sapiens 253-269 22436237-11 2012 Pharmacological inhibition of inducible nitric oxide synthase by 1400W reduced intracellular production of nitric oxide and prevented accumulation of beta-amyloid, nitration of tyrosine as well as cell death inflicted by interleukin-1beta combined with interferon-gamma. Nitric Oxide 40-52 interferon gamma Homo sapiens 253-269 22385242-8 2012 High doses of nifedipine (50 microM) increased MNCs apoptosis, inhibited T cell activation and decreased T helper type 2 (Th1) (IFN-gamma)/Th2 (IL-10) cytokine production in both groups. Nifedipine 14-24 interferon gamma Homo sapiens 128-137 22385243-3 2012 In this study, we demonstrate that engagement of another co-stimulatory receptor on both LPT and PBT, namely CD28, by a single monoclonal antibody (mAb), respectively, strongly activates the former but not the latter through a PI3-kinase dependent signalling pathway leading to the production of inflammatory cytokines such as interleukin (IL)-2, tumour necrosis factor (TNF)-alpha, interferon (IFN)-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF). CIS-(AMMINE)(CYCLOHEXYLAMINE)PLATINUM(II) COMPLEX 89-92 interferon gamma Homo sapiens 383-405 22385244-7 2012 Quantitative polymerase chain reaction (PCR), flow cytometry and Western blot analysis showed that TG2 expression was blocked completely when stimulation by either TNF-alpha or IFN-gamma was performed in the presence of nuclear factor (NF)-kappaB inhibitors (sulphasalazine and BAY-117082). Sulfasalazine 259-273 interferon gamma Homo sapiens 177-186 22385244-7 2012 Quantitative polymerase chain reaction (PCR), flow cytometry and Western blot analysis showed that TG2 expression was blocked completely when stimulation by either TNF-alpha or IFN-gamma was performed in the presence of nuclear factor (NF)-kappaB inhibitors (sulphasalazine and BAY-117082). 3-(4-methylphenylsulfonyl)-2-propenenitrile 278-288 interferon gamma Homo sapiens 177-186 22330085-0 2012 Increased production of nitric oxide by neutrophils from patients with chronic granulomatous disease on interferon-gamma treatment. Nitric Oxide 24-36 interferon gamma Homo sapiens 104-120 21980060-0 2012 Performance of confirmatory interferon-gamma release assays in school TB outbreaks. Terbium 70-72 interferon gamma Homo sapiens 28-44 22318141-7 2012 Our findings demonstrate that on poly(I C)/IFN-gamma-stimulated mDC from CHB patients, the expression of costimulatory molecules was enhanced, while cytokine production was reduced. Poly I-C 33-44 interferon gamma Homo sapiens 45-54 22318141-8 2012 In cocultures of poly(I C)/IFN-gamma-stimulated mDC and NK cells obtained from CHB patients, reduced mDC-induced NK cell activation (i.e., CD69 expression) and IFN-gamma production compared to those in healthy individuals was observed. Poly I-C 17-27 interferon gamma Homo sapiens 162-171 22460084-10 2012 The combination of TNF-alpha and IFN-gamma was able to induce apoptosis in primary EGCs, whereas these factors alone did not. egcs 83-87 interferon gamma Homo sapiens 33-42 22279179-6 2012 Furthermore, activation of p38 MAPK up-regulated the initial IL-12 production and the activation of ERK1/2 in tandem with GSH, found responsible for IFN-gamma production by TAMs. Glutathione 122-125 interferon gamma Homo sapiens 149-158 22279179-6 2012 Furthermore, activation of p38 MAPK up-regulated the initial IL-12 production and the activation of ERK1/2 in tandem with GSH, found responsible for IFN-gamma production by TAMs. Tamoxifen 173-177 interferon gamma Homo sapiens 149-158 21796650-10 2012 Conditioned media of glucan-treated DC/LNCaP co-cultures activated IFN-gamma production by NK cells and Th1/Th17 generation by CD4(+) lymphocytes, whereas media from DC/LNCaP co-cultured without glucan produced scarce NK and CD4(+) cells responses. Glucans 21-27 interferon gamma Homo sapiens 67-76 22522462-6 2012 It is of note that HP-NAP-treated tumors show also a reduced vascularization due to the anti-angiogenic activity of IFN-gamma induced by HP-NAP. hp-nap 19-25 interferon gamma Homo sapiens 116-125 22522462-6 2012 It is of note that HP-NAP-treated tumors show also a reduced vascularization due to the anti-angiogenic activity of IFN-gamma induced by HP-NAP. hp-nap 137-143 interferon gamma Homo sapiens 116-125 22541112-10 2012 When hUC-MSC were stimulated by IFN-gamma for 24 h, the production of PGE-2 secreted by hUC-MSC decreased significantly (P < 0.01). Dinoprostone 70-75 interferon gamma Homo sapiens 32-41 22326778-4 2012 Immunization with EDAp24 fusion protein together with poly(I:C) adjuvant induced a specific p24 IFN-gamma production (Th1 profile) as well as protection against a Lm-Gag challenge, suggesting an additive or synergistic effect between both adjuvants. poly(i:c) adjuvant 54-72 interferon gamma Homo sapiens 96-105 22803426-0 2012 [Effects of ligustrazine injection on IL-2, IL-10, and IFN-gamma in patients undergoing spinal operation after autologous blood transfusion]. tetramethylpyrazine 12-24 interferon gamma Homo sapiens 55-64 22369947-4 2012 We screened our chemical libraries using a cell-based Kyn production assay to identify a new type of small molecules that regulate Kyn production, and for the first time identified a benzenesulfonamide derivative (compound 1) as a hit with the ability to inhibit Kyn production in interferon-gamma (IFN-gamma)-stimulated A431 and HeLa cells. benzenesulfonamide 183-201 interferon gamma Homo sapiens 281-297 22369947-4 2012 We screened our chemical libraries using a cell-based Kyn production assay to identify a new type of small molecules that regulate Kyn production, and for the first time identified a benzenesulfonamide derivative (compound 1) as a hit with the ability to inhibit Kyn production in interferon-gamma (IFN-gamma)-stimulated A431 and HeLa cells. benzenesulfonamide 183-201 interferon gamma Homo sapiens 299-308 22413885-5 2012 RESULTS: Calcium-dependent activation of T cells using CD3/CD28 and PMA/CD3 stimulation induced a Th1 expression profile reflected by increased expression of T-bet, RUNX3, IL-2, and IFNgamma, whereas calcium-independent activation via PMA/CD28 induced a Th2 expression profile which included GATA3, RXRA, CCL1 and Itk. Calcium 9-16 interferon gamma Homo sapiens 182-190 22413812-12 2012 After stimulation with H2O2 or IFNgamma for 48 hours, IL-32 expression in HBE cells was increased by IFNgamma and synergistically upregulated by the addition of H2O2. Hydrogen Peroxide 23-27 interferon gamma Homo sapiens 101-109 22535397-8 2012 Piperine inhibited IL-2 and IFN-gamma production in the PBMCs. piperine 0-8 interferon gamma Homo sapiens 28-37 22535397-9 2012 RT-PCR data indicated that IL-2 and IFN-gamma mRNA expression in PBMCs is suppressed by piperine. piperine 90-98 interferon gamma Homo sapiens 37-46 22413812-12 2012 After stimulation with H2O2 or IFNgamma for 48 hours, IL-32 expression in HBE cells was increased by IFNgamma and synergistically upregulated by the addition of H2O2. Hydrogen Peroxide 161-165 interferon gamma Homo sapiens 31-39 22413812-13 2012 The H2O2 augmented IFNgamma induced IL-32 mRNA expression was suppressed by a JNK inhibitor, but not by MEK inhibitor, p38 inhibitor, and JAK inhibitor I. Hydrogen Peroxide 4-8 interferon gamma Homo sapiens 19-27 22413812-14 2012 Significant binding of c-Jun and CREB to the IL-32 promoter was observed in the IFNgamma + H2O2 stimulated HBE cells. Hydrogen Peroxide 91-95 interferon gamma Homo sapiens 80-88 22417244-8 2012 RESULTS: The inhibition of PHA/PMA stimulated IFNgamma production by dexamethasone was reduced in COPD patients compared to HNS (p < 0.05 at concentrations from 0.1-1 muM). Dexamethasone 69-82 interferon gamma Homo sapiens 46-54 22297175-8 2012 Priming of cells with the inflammatory stimulus LPS/IFN-gamma markedly enhanced the slower, but not rapid, phase of BzATP-induced [Ca2+]i with application of 10 mMMg2+ inhibiting both components of response. BzATP 116-121 interferon gamma Homo sapiens 52-61 21804607-9 2012 IFN-gamma independent induction of HLA-DR genes and their encoded proteins was also demonstrated upon doxycyclin-regulated transient induction of AIM2. Doxycycline 102-112 interferon gamma Homo sapiens 0-9 22154859-8 2012 Our data provide the knowledge of microscopic surface structures and cell biology basis for synthesizing the thermoplastic polyurethane biomaterials with co-immobilized IFN-gamma plus TNF-alpha, which are promising for novel therapeutics (e.g. drug cup) design for cervical cancer patients. Polyurethanes 123-135 interferon gamma Homo sapiens 169-178 22297175-8 2012 Priming of cells with the inflammatory stimulus LPS/IFN-gamma markedly enhanced the slower, but not rapid, phase of BzATP-induced [Ca2+]i with application of 10 mMMg2+ inhibiting both components of response. mmmg2+ 161-167 interferon gamma Homo sapiens 52-61 22116002-6 2012 Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1. Poly I-C 0-8 interferon gamma Homo sapiens 96-112 22288594-5 2012 Multifunctional CD4(+) T cells showed the highest mean fluorescence intensity (MFI) for the three Th1 cytokines assessed and MFIs for IFN-gamma and interleukin-2 from those cells stimulated with LbAg were significantly higher than those obtained after LaAg stimulation. lbag 195-199 interferon gamma Homo sapiens 134-143 22121051-5 2012 Generation of IL-2 and IFN-gamma by T cells of younger and older subjects was suppressed substantially only at adenosine levels of 3 muM or higher. Adenosine 111-120 interferon gamma Homo sapiens 23-32 22205701-2 2012 Macrophages primed with IFNgamma or other pro-inflammatory mediators respond to FcgammaR engagement by secreting high levels of cytokines and nitric oxide (NO). Nitric Oxide 142-154 interferon gamma Homo sapiens 24-32 22351660-7 2012 RESULTS: At 1000 ppm DIM, serum IFN-gamma concentrations were significantly increased (p<0.0396). 3,3'-diindolylmethane 21-24 interferon gamma Homo sapiens 32-41 21962843-0 2012 Circulating interferon-gamma-inducible Cys-X-Cys chemokine receptor 3 ligands are elevated in humans with aortic aneurysms and Cys-X-Cys chemokine receptor 3 is necessary for aneurysm formation in mice. Cysteine 39-42 interferon gamma Homo sapiens 12-28 21923628-5 2012 RESULTS: Patients included at the beginning of treatment responded producing IFN-gamma after antigen stimulation in 89.7% by means of T-SPOT.TB and 79.3% by means of RD1 selected ELISPOT. Terbium 141-143 interferon gamma Homo sapiens 77-86 22193340-3 2012 The presence of IFN-gamma opens the hairpin structure and forms the hemin/G-quadruplex peroxidase-mimicking DNAzyme with subsequent addition of hemin. Hemin 68-73 interferon gamma Homo sapiens 16-25 22193340-4 2012 The peroxidase-mimicking DNAzyme catalyzes the electro-reduction of H(2)O(2) and amplifies the current response for IFN-gamma detection, which enables the monitoring of IFN-gamma at the sub-nanomolar level. Hydrogen Peroxide 68-76 interferon gamma Homo sapiens 116-125 22193340-4 2012 The peroxidase-mimicking DNAzyme catalyzes the electro-reduction of H(2)O(2) and amplifies the current response for IFN-gamma detection, which enables the monitoring of IFN-gamma at the sub-nanomolar level. Hydrogen Peroxide 68-76 interferon gamma Homo sapiens 169-178 22333315-11 2012 PGE2 impairs IFN-gamma mediated CXCL9 and CXCL10 release from MCF-7 and MDA-MB 231 cells, and inhibition of endogenous cyclooxygenases by indomethacin or ASA correspondingly increases this secretion. Dinoprostone 0-4 interferon gamma Homo sapiens 13-22 22335964-7 2012 Minocycline significantly inhibited spontaneous lymphoproliferation and degranulation/IFN-gamma expression in CD8+ T cells of HAM/TSP patients. Minocycline 0-11 interferon gamma Homo sapiens 86-95 22335964-8 2012 Treatment of minocycline also inhibited IFN-gamma expression in CD8+ T cells of HAM/TSP patients after Tax11-19 stimulation and downregulated MHC class I expression in CD14+ cells. Minocycline 13-24 interferon gamma Homo sapiens 40-49 22169811-6 2012 Consistent with their channel phenotypes, the production of interferon-gamma and perforin in CD4(+)CD28null T cells was suppressed by the specific Kv1.3 blocker 5-(4-phenoxybutoxy)psoralen PAP-1. (4-phenoxybutoxy 163-179 interferon gamma Homo sapiens 60-76 21952924-5 2012 TSA was a potent inhibitor of tumor necrosis factor (TNF) and interleukin-6 (IL-6) production in both RA and healthy PBMCs and of interferon-gamma (IFNgamma) production in healthy PBMCs; IFNgamma was not produced by RA PBMCs. trichostatin A 0-3 interferon gamma Homo sapiens 130-146 21952924-5 2012 TSA was a potent inhibitor of tumor necrosis factor (TNF) and interleukin-6 (IL-6) production in both RA and healthy PBMCs and of interferon-gamma (IFNgamma) production in healthy PBMCs; IFNgamma was not produced by RA PBMCs. trichostatin A 0-3 interferon gamma Homo sapiens 148-156 21952924-5 2012 TSA was a potent inhibitor of tumor necrosis factor (TNF) and interleukin-6 (IL-6) production in both RA and healthy PBMCs and of interferon-gamma (IFNgamma) production in healthy PBMCs; IFNgamma was not produced by RA PBMCs. trichostatin A 0-3 interferon gamma Homo sapiens 187-195 22029653-9 2012 Cells expanded with either zoledronate or IPP were active in ADCC, were similar in terms of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha expression, and degranulated in response to Fc receptor cross-linking. Zoledronic Acid 27-38 interferon gamma Homo sapiens 92-114 22154514-6 2012 When the aMCI group was stratified by APOEepsilon4 status, significant differences were found between the low- and high-risk groups and controls in the levels of IL-6 and IFN-gamma (P<0.01 and P=0.041, respectively). amci 9-13 interferon gamma Homo sapiens 171-180 22247226-6 2012 Moreover, simultaneous injection of alphaGC with sulfatide decreased alphaGC/CD1d complex formations on DCs, accompanied by the reduced CD40L-up-regulation and IFN-gamma production by iNKT cells and IL-12p70 production by DCs. Sulfoglycosphingolipids 49-58 interferon gamma Homo sapiens 160-169 21915712-5 2012 The presence of IRX-2 in the co-cultures promoted the induction and expansion of IFN-gamma(+)Tbet(+) Teff and significantly (p < 0.01) decreased the induction of inducible IL-10(+)TGF-beta(+) Treg. tbet 93-97 interferon gamma Homo sapiens 81-90 22120597-1 2012 OBJECTIVE: The purpose of this study was to examine the usefulness of the TST and the interferon-gamma release assays (IGRA) for diagnosing smear-negative pulmonary TB in immunocompromised patients in an intermediate TB burden. Terbium 165-167 interferon gamma Homo sapiens 86-102 22124136-3 2012 In this work, we demonstrate that TSA, VPA, and NaB inhibited IFN-gamma production by CD56(dim) and CD56(bright) NK cells and NK cell-mediated cytotoxicity against K562 target cells. trichostatin A 34-37 interferon gamma Homo sapiens 62-71 22124136-3 2012 In this work, we demonstrate that TSA, VPA, and NaB inhibited IFN-gamma production by CD56(dim) and CD56(bright) NK cells and NK cell-mediated cytotoxicity against K562 target cells. Valproic Acid 39-42 interferon gamma Homo sapiens 62-71 22124136-3 2012 In this work, we demonstrate that TSA, VPA, and NaB inhibited IFN-gamma production by CD56(dim) and CD56(bright) NK cells and NK cell-mediated cytotoxicity against K562 target cells. nab 48-51 interferon gamma Homo sapiens 62-71 22037448-0 2012 Histamine increases the level of IFNgamma produced by HIV-1 specific CTLs and this production depends on total IgE level. Histamine 0-9 interferon gamma Homo sapiens 33-41 21958213-12 2012 Within the L-ETB group, MTBs-induced IFNgamma was greater in patients with tuberculous lymphadenitis than those with pleural TB (P = 0.002). mtbs 24-28 interferon gamma Homo sapiens 37-45 22037448-6 2012 Changes in the production of IFNgamma after incubation with histamine were compared with the levels of total IgE (immunoglobulin E, measured using a Dade Behring analyzer), because histamine is endogenously released through IgE. Histamine 60-69 interferon gamma Homo sapiens 29-37 22037448-9 2012 CONCLUSIONS: We found an increase in IFNgamma production after the activation of HIV-1 specific CD8+ T lymphocytes by histamine (this elevation was blocked by cimetidine), furthermore, we demonstrated a negative correlation between the production of IFNgamma and levels of total IgE. Histamine 118-127 interferon gamma Homo sapiens 37-45 22037448-9 2012 CONCLUSIONS: We found an increase in IFNgamma production after the activation of HIV-1 specific CD8+ T lymphocytes by histamine (this elevation was blocked by cimetidine), furthermore, we demonstrated a negative correlation between the production of IFNgamma and levels of total IgE. Histamine 118-127 interferon gamma Homo sapiens 250-258 22037448-9 2012 CONCLUSIONS: We found an increase in IFNgamma production after the activation of HIV-1 specific CD8+ T lymphocytes by histamine (this elevation was blocked by cimetidine), furthermore, we demonstrated a negative correlation between the production of IFNgamma and levels of total IgE. Cimetidine 159-169 interferon gamma Homo sapiens 37-45 22037448-9 2012 CONCLUSIONS: We found an increase in IFNgamma production after the activation of HIV-1 specific CD8+ T lymphocytes by histamine (this elevation was blocked by cimetidine), furthermore, we demonstrated a negative correlation between the production of IFNgamma and levels of total IgE. Cimetidine 159-169 interferon gamma Homo sapiens 250-258 21864915-7 2012 Neopterin is a reliable indicator for interferon-gamma (IFN-gamma) which was identified as the only cytokine that induces significant production of neopterin. Neopterin 0-9 interferon gamma Homo sapiens 38-54 21864915-7 2012 Neopterin is a reliable indicator for interferon-gamma (IFN-gamma) which was identified as the only cytokine that induces significant production of neopterin. Neopterin 0-9 interferon gamma Homo sapiens 56-65 21864915-7 2012 Neopterin is a reliable indicator for interferon-gamma (IFN-gamma) which was identified as the only cytokine that induces significant production of neopterin. Neopterin 148-157 interferon gamma Homo sapiens 38-54 21864915-7 2012 Neopterin is a reliable indicator for interferon-gamma (IFN-gamma) which was identified as the only cytokine that induces significant production of neopterin. Neopterin 148-157 interferon gamma Homo sapiens 56-65 21864915-8 2012 Considering recent research indicating that IFN-gamma can lead to increased neuronal responsiveness and body perceptions by reducing inhibitory tone in the dorsal horn, the observed association between somatization syndromes and neopterin might support the idea of central sensitization in the pathogenesis of somatoform symptoms. Neopterin 229-238 interferon gamma Homo sapiens 44-53 22251670-6 2012 Apoptosis in cultured EGC was induced by TNF-alpha and IFN-gamma, and the influence of GDNF on apoptosis was measured upon addition of GDNF or neutralizing anti-GDNF antibody. (-)-Epigallocatechin 22-25 interferon gamma Homo sapiens 55-64 22227193-3 2012 The aim of this study was to investigate the possible mechanism by which casuarinin inhibits TNF-alpha/IFN-gamma-induced Th2 chemokines expression in the human keratinocytes cell line HaCaT. casuarinin 73-83 interferon gamma Homo sapiens 103-112 22227193-4 2012 We found that casuarinin suppressed TNF-alpha/IFN-gamma-induced expression of TARC and MDC mRNA and protein in HaCaT cells. casuarinin 14-24 interferon gamma Homo sapiens 46-55 22227193-5 2012 Casuarinin significantly inhibited TNF-alpha/IFN-gamma-induced activation of NF-kappaB, STAT1, and p38 MAPK. casuarinin 0-10 interferon gamma Homo sapiens 45-54 22227193-7 2012 Taken together, these results suggest that casuarinin may exert anti-inflammatory responses by suppressing TNF-alpha/IFN-gamma-induced expression of TARC and MDC via blockage of p38 MAPK activation and subsequent activation of NF-kappaB and STAT1. casuarinin 43-53 interferon gamma Homo sapiens 117-126 22280502-6 2012 Th1 and pro-inflammatory responses were higher than Th2 and anti-inflammatory responses, respectively, and IFN-gamma:IL-4 ratios were higher for placebo than for SP recipients. TFF2 protein, human 162-164 interferon gamma Homo sapiens 107-116 22128302-7 2012 VTX-2337 stimulates IFNgamma production from NK cells and increases the cytotoxicity of NK cells against K562 and ADCC by rituximab and trastuzumab. VTX-2337 0-8 interferon gamma Homo sapiens 20-28 21351096-7 2012 These results indicated that cyclophosphamide-induced reduction of recipient Tregs is associated with retardation of tumor progression via the expansion of host-reactive donor T cells and IFN-gamma production after DLI in our nonmyeloablative SCT system. Cyclophosphamide 29-45 interferon gamma Homo sapiens 188-197 22128302-8 2012 Effects of VTX-2337 on NK cells were, in part, from direct activation as increased IFNgamma production and cytotoxic activity were seen with purified NK cells. VTX-2337 11-19 interferon gamma Homo sapiens 83-91 22119708-6 2012 PFBS, PFOSA, PFOS, PFDA and fluorotelomer inhibited PHA-induced IL-10 release, while IFN-gamma secretion was affected by PFOSA, PFOS, PFDA and fluorotelomer. perfluorodecanoic acid 134-138 interferon gamma Homo sapiens 85-94 23326799-0 2012 The effect of interferon gamma on endothelial cell nitric oxide production and apoptosis. Nitric Oxide 51-63 interferon gamma Homo sapiens 14-30 22008665-9 2012 We found the recipients with higher IL-18 and IFN-gamma serum levels had lower tacrolimus concentration/dose (C/D) ratios (P<0.05). Tacrolimus 79-89 interferon gamma Homo sapiens 46-55 22919591-10 2011 Activation of these PTPs negatively regulates interferon-gamma signaling and this prevents effective expression of the macrophage microbicidal arsenal, including TNF-alpha and nitric oxide. Nitric Oxide 176-188 interferon gamma Homo sapiens 46-62 22718606-4 2012 Polyclonal T cell activation in vitro by Staphylococcal exotoxin B induced co-ordinate IFN-gamma production from paired maternal and fetal mononuclear cells, accompanied by co-ordinate increases in activated CD4+CD69+ cells that display the CCR4+Th2 and CXCR3+ Th1 phenotypes. staphylococcal exotoxin b 41-66 interferon gamma Homo sapiens 87-96 23289226-3 2012 The nucleotide sequence which is complementary contacted with peptide Ala-Glu-Asp-Gly was found in promoter region of interferon gamma gene. Alanine 70-73 interferon gamma Homo sapiens 118-134 22038826-0 2012 Curcumin inhibits interferon-gamma signaling in colonic epithelial cells. Curcumin 0-8 interferon gamma Homo sapiens 18-34 23289226-3 2012 The nucleotide sequence which is complementary contacted with peptide Ala-Glu-Asp-Gly was found in promoter region of interferon gamma gene. Glutamic Acid 74-77 interferon gamma Homo sapiens 118-134 23289226-3 2012 The nucleotide sequence which is complementary contacted with peptide Ala-Glu-Asp-Gly was found in promoter region of interferon gamma gene. Aspartic Acid 78-81 interferon gamma Homo sapiens 118-134 23289226-3 2012 The nucleotide sequence which is complementary contacted with peptide Ala-Glu-Asp-Gly was found in promoter region of interferon gamma gene. Glycine 82-85 interferon gamma Homo sapiens 118-134 21420224-8 2012 RESULTS: The addition of ascorbate to in vitro culture gliadin-challenged biopsies blocked the secretion of nitrites (p=0.013), IFNgamma (p=0.0207), TNFalpha (p=0.0099), IFNalpha (p=0.0375), and IL-6 (p=0.0036) compared to samples from non-ascorbate supplemented culture. Ascorbic Acid 25-34 interferon gamma Homo sapiens 128-136 21420224-9 2012 Cytokine secretion was downregulated by ascorbate even to lower values than those observed in basal cultures (IFNgamma: p=0.0312; TNFalpha: p=0.0312; IFNalpha: p=0.0312; and IL-6: p=0.0078). Ascorbic Acid 40-49 interferon gamma Homo sapiens 110-118 22038826-4 2012 In this report we demonstrate that curcumin inhibits IFN-gamma signaling in human and mouse colonocytes. Curcumin 35-43 interferon gamma Homo sapiens 53-62 22038826-5 2012 Curcumin inhibited IFN-gamma-induced gene transcription, including CII-TA, MHC-II genes (HLA-DRalpha, HLA-DPalpha1, HLA-DRbeta1), and T cell chemokines (CXCL9, 10, and 11). Curcumin 0-8 interferon gamma Homo sapiens 19-28 22038826-8 2012 In summary, curcumin acts as an IFN-gamma signaling inhibitor in colonocytes with biphasic mechanisms of action, a phenomenon that may partially account for the beneficial effects of curcumin in experimental colitis and in human IBD. Curcumin 12-20 interferon gamma Homo sapiens 32-41 22038826-8 2012 In summary, curcumin acts as an IFN-gamma signaling inhibitor in colonocytes with biphasic mechanisms of action, a phenomenon that may partially account for the beneficial effects of curcumin in experimental colitis and in human IBD. Curcumin 183-191 interferon gamma Homo sapiens 32-41 22056360-5 2012 We further showed that EGCG reduced production of interferon-gamma, IL-17, IL-6, IL-1beta, and tumor necrosis factor-alpha; decreased types 1 and 17 helper T cells (Th1 and Th17, respectively); and increased regulatory T-cell populations in lymph nodes, the spleen, and the central nervous system. epigallocatechin gallate 23-27 interferon gamma Homo sapiens 50-66 22993937-3 2012 The treatment with azithromycin, in addition to the high eradication rates, was also evident of its effect on the cytokine levels in the patients, that was characteristic of a significant increase of the IFN-gamma level and a decrease of the IL-1beta and IL-6 levels in the blood. Azithromycin 19-31 interferon gamma Homo sapiens 204-213 22400102-8 2012 The expression of HLA-DR molecules induced by interferon-gamma in the presence of sodium selenite of various concentration was measured by fluorescence-activated cell sorter. Sodium Selenite 82-97 interferon gamma Homo sapiens 46-62 22741199-6 2012 The use of cycloferon in the treatment scheme resulted in increase of the interferon-alpha levels and decrease of the higher levels of interferon-gamma. 10-carboxymethyl-9-acridanone 11-21 interferon gamma Homo sapiens 135-151 22400102-10 2012 Selenium has a dose-dependent inhibitory effect on the expression of HLA-DR molecules of thyrocytes induced by interferon-gamma. Selenium 0-8 interferon gamma Homo sapiens 111-127 23057161-9 2012 Aspirin-, dexamethasone- VD3- and butyric acid-modified DCs suppressed interferon-gamma production, proliferation and cytotoxicity in co-culture with allogeneic mononuclear cells, but inconsistent results were obtained with different allogeneic combinations. Aspirin 0-7 interferon gamma Homo sapiens 71-87 22975513-8 2012 The anti-inflammatory agent dexamethasone inhibited IFNgamma induction of STS gene expression, suggesting involvement of a glucocorticoid receptor in the regulation of STS gene expression in keratinocytes. Dexamethasone 28-41 interferon gamma Homo sapiens 52-60 23057161-9 2012 Aspirin-, dexamethasone- VD3- and butyric acid-modified DCs suppressed interferon-gamma production, proliferation and cytotoxicity in co-culture with allogeneic mononuclear cells, but inconsistent results were obtained with different allogeneic combinations. Dexamethasone 10-23 interferon gamma Homo sapiens 71-87 23057161-9 2012 Aspirin-, dexamethasone- VD3- and butyric acid-modified DCs suppressed interferon-gamma production, proliferation and cytotoxicity in co-culture with allogeneic mononuclear cells, but inconsistent results were obtained with different allogeneic combinations. Butyric Acid 34-46 interferon gamma Homo sapiens 71-87 21669040-5 2012 Exenatide treatment improved islet function, significantly reduced content of inflammation-related molecules (tissue factor, IFN-gamma, IL-17, IL-1beta, and IL-2) and caspase 3 activation, whereas increased phosphorylation of ERK1/2, STAT3, and Akt in vitro. Exenatide 0-9 interferon gamma Homo sapiens 126-135 21807089-8 2012 Co-culture of resveratrol-induced CD11b(+) Gr-1(+) cells with T cells, attenuated T cell proliferation, and most importantly reduced IFN-gamma and GM-CSF production by LP derived T cells from vehicle treated IL-10(-/-) mice with chronic colitis. Resveratrol 14-25 interferon gamma Homo sapiens 133-142 22613980-0 2012 Protective role of oligomycin against intestinal epithelial barrier dysfunction caused by IFN-gamma and TNF-alpha. Oligomycins 19-29 interferon gamma Homo sapiens 90-99 22613980-2 2012 This study was aimed to investigate the protective role of HIF-1alpha inhibitor oligomycin against intestinal epithelial barrier dysfunction induced by proinflammatory cytokines IFN-gamma and TNF-alpha, and the underlying mechanisms. Oligomycins 80-90 interferon gamma Homo sapiens 178-187 22613980-5 2012 The results showed that at the concentration of blocking HIF-1alpha activation, oligomycin significantly ameliorated TER reduction and paracellular permeability increase in Caco-2 monolayers challenged with IFN-gamma and TNF-alpha. Oligomycins 80-90 interferon gamma Homo sapiens 207-216 22613980-6 2012 Oligomycin also largely attenuated the IFN-gamma and TNF-alpha-related relocalization of tight junction proteins ZO-1 and occludin. Oligomycins 0-10 interferon gamma Homo sapiens 39-48 22613980-7 2012 Western blot analysis revealed that oligomycin abolished the increases of both MLC phosphorylation and MLCK protein expression induced by IFN-gamma and TNF-alpha challenge. Oligomycins 36-46 interferon gamma Homo sapiens 138-147 22613980-8 2012 Quantitative RT-PCR analysis showed that oligomycin inhibited the IFN-gamma and TNF-alpha-induced up-regulation of MLCK mRNA. Oligomycins 41-51 interferon gamma Homo sapiens 66-75 22613980-9 2012 It is concluded that oligomycin is able to attenuate intestinal epithelial barrier dysfunction induced by proinflammatory cytokines IFN-gamma and TNF-alpha. Oligomycins 21-31 interferon gamma Homo sapiens 132-141 22613980-10 2012 The mechanism by which oligomycin protects intestinal barrier function may, at least in part, be attributed to block the up-regulated MLCK transcription and protein expression induced by IFN-gamma and TNF-alpha. Oligomycins 23-33 interferon gamma Homo sapiens 187-196 22137120-13 2012 Inhibition of PI3K with LY294002 prevented IFNgamma-mediated actin polymerization. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 24-32 interferon gamma Homo sapiens 43-51 23507624-3 2012 This study intends to determine the effects of isoproterenol (ISO; beta-agonist) and propranolol (PRO; beta-antagonist) on the production of IFN-gamma, IL-4, and IL-17. Isoproterenol 47-60 interferon gamma Homo sapiens 141-150 23507624-3 2012 This study intends to determine the effects of isoproterenol (ISO; beta-agonist) and propranolol (PRO; beta-antagonist) on the production of IFN-gamma, IL-4, and IL-17. Propranolol 85-96 interferon gamma Homo sapiens 141-150 21930443-5 2012 Similarly, FACS analysis and ELISA testing demonstrated that Vitamin D3 significantly decreased the response frequency and the response intensity of IFN-gamma and TNF-alpha production in the whole CD3-positive T lymphocyte population as well as in "naive" CD4+ CD45RA+ and "memory" CD4+ CD45RO+ T lymphocyte subsets. Cholecalciferol 61-71 interferon gamma Homo sapiens 149-158 22834123-1 2012 Research performed at the Grodno Regional Clinical Center "Phthisiology" was aimed at studying the dynamics of IFN-gamma and IL-4 in serum of patients with widespread forms of pulmonary tuberculosis, treated by polychemotherapy with the use of cycloferon. 10-carboxymethyl-9-acridanone 244-254 interferon gamma Homo sapiens 111-120 22834123-6 2012 The administration of cycloferon in the complex therapy of patients with widespread forms leads to an increase in the IFN-gamma concentration at initially low levels (below median level of this cytokine in healthy humans). 10-carboxymethyl-9-acridanone 22-32 interferon gamma Homo sapiens 118-127 22891441-3 2012 Administration of the interferon inductor (cycloferon) favors positive clinical and laboratory dynamics of the tubercular process, increases the level of endogenous IFN-gamma (especially for an initial level below 100 pg/ml), and restricts the expression of drug-induced hepatotoxicity reactions. 10-carboxymethyl-9-acridanone 43-53 interferon gamma Homo sapiens 165-174 22207354-8 2012 For participants who had obstructive pulmonary disease at their baseline visit, the rate of change of methylation of IFNgamma was -0.05% 5-methyl-cytosine (5-mC) per year (95% CI: -0.22, 0.13), but was 0.14% 5-mC per year (95% CI: 0.05, 0.24) for those without this condition. 5-Methylcytosine 137-154 interferon gamma Homo sapiens 117-125 22207354-8 2012 For participants who had obstructive pulmonary disease at their baseline visit, the rate of change of methylation of IFNgamma was -0.05% 5-methyl-cytosine (5-mC) per year (95% CI: -0.22, 0.13), but was 0.14% 5-mC per year (95% CI: 0.05, 0.24) for those without this condition. 5-Methylcytosine 156-160 interferon gamma Homo sapiens 117-125 22207354-8 2012 For participants who had obstructive pulmonary disease at their baseline visit, the rate of change of methylation of IFNgamma was -0.05% 5-methyl-cytosine (5-mC) per year (95% CI: -0.22, 0.13), but was 0.14% 5-mC per year (95% CI: 0.05, 0.24) for those without this condition. 5-Methylcytosine 208-212 interferon gamma Homo sapiens 117-125 22685485-9 2012 The results showed that lipopolysaccharide/interferon-gamma (LPS/INF-gamma) increased nitrous oxide (NO) production inR AW264.7macrophages, whereas N(G)-nitro-L-argininemethyl ester (L-NAME) and CLG curtailed it. Nitrous Oxide 86-99 interferon gamma Homo sapiens 43-59 22685485-9 2012 The results showed that lipopolysaccharide/interferon-gamma (LPS/INF-gamma) increased nitrous oxide (NO) production inR AW264.7macrophages, whereas N(G)-nitro-L-argininemethyl ester (L-NAME) and CLG curtailed it. NG-Nitroarginine Methyl Ester 183-189 interferon gamma Homo sapiens 43-59 22685485-9 2012 The results showed that lipopolysaccharide/interferon-gamma (LPS/INF-gamma) increased nitrous oxide (NO) production inR AW264.7macrophages, whereas N(G)-nitro-L-argininemethyl ester (L-NAME) and CLG curtailed it. Clorgyline 195-198 interferon gamma Homo sapiens 43-59 22025513-4 2012 Here, we show that in HeLa cells infected with gamma interferon (IFN-gamma)-induced persistent C. trachomatis serovar D, the expression of CPAF is downregulated, and proapoptotic protease substrates are not cleaved. 1-O-hexadecyl-2-N-methylcarbamol -sn-glycerol-3-phosphocholine 139-143 interferon gamma Homo sapiens 47-74 22154580-8 2012 Furthermore, the exposure of DCs to risperidone led to lower IFN-gamma production by T-cells. Risperidone 36-47 interferon gamma Homo sapiens 61-70 22072376-7 2012 IDO expression and enzyme activity was markedly induced following IFN-gamma stimulation, but this induction was prevented by the IDO specific inhibitor, 1-methyl tryptophan (1-MT). 1-methyltryptophan 153-172 interferon gamma Homo sapiens 66-75 22489138-4 2012 Our current study demonstrated that BDMC33 inhibits the secretion of major pro-inflammatory mediators in stimulated macrophages, and includes NO, TNF-alpha and IL-1beta through interference in both nuclear factor kappaB (NF-kappaB) and mitogen activator protein kinase (MAPK) signaling cascade in IFN-gamma/LPS-stimulated macrophages. 2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone 36-42 interferon gamma Homo sapiens 297-306 22489138-6 2012 In addition, the inhibitory action of BDMC33 not only restricted the macrophages cell (RAW264.7), but also inhibited the secretion of NO and TNF-alpha in IFN-gamma/LPS-challenged microglial cells (BV-2). 2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone 38-44 interferon gamma Homo sapiens 154-163 22701318-9 2012 Iron oxide nanoparticles also demonstrated a suppressive effect on ovalbumin-stimulated production of interferon-gamma by splenocytes and the phagocytic activity of splenic CD11b(+) cells. ferric oxide 0-10 interferon gamma Homo sapiens 102-118 22429354-7 2012 RESULTS: Patients in the ropivacaine group (thoracic epidural block) had a significantly lower IFN-gamma/IL-4 ratio at the end of surgery than those in the remifentanil group and clonidine group. Ropivacaine 25-36 interferon gamma Homo sapiens 95-104 22235780-8 2012 Correlated with these effects, we observed a distinct clustering of GM1(+) lipid microdomains at the plasma membrane and enhanced phosphorylation of LAT and PKCtheta which may be related to an observed enhancement of Ag-specific effector CD8+ T cell IFN-gamma gene transcription following mild hyperthermia. G(M1) Ganglioside 68-74 interferon gamma Homo sapiens 250-259 22517709-8 2012 CONCLUSION: Our findings support that with carboplatin/ paclitaxel combination chemotherapy, important parameters of the immune system (IFN-gamma, CD4, CD4/CD8) can be used as prognostic factors for survival, while others (IL-3) as indicators of toxicity. Carboplatin 43-54 interferon gamma Homo sapiens 136-145 22517709-8 2012 CONCLUSION: Our findings support that with carboplatin/ paclitaxel combination chemotherapy, important parameters of the immune system (IFN-gamma, CD4, CD4/CD8) can be used as prognostic factors for survival, while others (IL-3) as indicators of toxicity. Paclitaxel 56-66 interferon gamma Homo sapiens 136-145 22000712-7 2012 Furthermore, it is predicted that alternative attempts to treat inflammatory diseases by blocking other pivotal cytokines that also participate in iron homeostasis (e.g. IFN-gamma, IL-1, and IL-6) will similarly be associated with infections and neoplastic complications. Iron 147-151 interferon gamma Homo sapiens 170-179 22690041-6 2012 The percentage of CD4(+) cells producing interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in response to PMA/ionomycin was significantly reduced in pregnancy. Tetradecanoylphorbol Acetate 129-132 interferon gamma Homo sapiens 41-68 22570512-5 2012 No obvious changes were observed in Th1 cell frequencies; although, IFN-gamma expression was upregulated in response to telbivudine treatment, suggesting another cell source of IFN-gamma in CHB patients. Telbivudine 120-131 interferon gamma Homo sapiens 68-77 22570512-5 2012 No obvious changes were observed in Th1 cell frequencies; although, IFN-gamma expression was upregulated in response to telbivudine treatment, suggesting another cell source of IFN-gamma in CHB patients. Telbivudine 120-131 interferon gamma Homo sapiens 177-186 22690041-6 2012 The percentage of CD4(+) cells producing interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in response to PMA/ionomycin was significantly reduced in pregnancy. Ionomycin 133-142 interferon gamma Homo sapiens 41-68 22969169-15 2012 Serum neopterin correlated with hsCRP (r = 0.285, P = 0.002), IL-6 (r = 0.212, P = 0.034), and IFN-gamma (r = 0.32, P = 0.001) but not with TNF-alpha. Neopterin 6-15 interferon gamma Homo sapiens 95-104 22701277-2 2012 Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-gamma-) prime macrophage and triggers cytokine-driven inflammatory reactions. picolinic acid 0-14 interferon gamma Homo sapiens 78-94 22701277-2 2012 Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-gamma-) prime macrophage and triggers cytokine-driven inflammatory reactions. picolinic acid 0-14 interferon gamma Homo sapiens 97-106 22701277-2 2012 Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-gamma-) prime macrophage and triggers cytokine-driven inflammatory reactions. picolinic acid 16-18 interferon gamma Homo sapiens 78-94 22701277-2 2012 Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-gamma-) prime macrophage and triggers cytokine-driven inflammatory reactions. picolinic acid 16-18 interferon gamma Homo sapiens 97-106 21956503-3 2012 We worked out a protocol to study oxidative stress in human peripheral blood lymphocytes by determining their potency to secrete IFN-gamma, IL-2, IL-4, IL-5, IL-8, and TNF-alpha in response to acute treatment with hydrogen peroxide. Hydrogen Peroxide 214-231 interferon gamma Homo sapiens 129-138 23093820-9 2012 Comparison of the dose-dependent inhibition of chemokine (IL-8, IP-10, MCP-1) and growth factor (GM-CSF) release from PHK activated by TNFalpha + IFNgamma showed that leontopodic acid was mainly responsible for the inhibitory effects of ECC55. leontopodic acid 167-183 interferon gamma Homo sapiens 146-154 21956503-4 2012 We show that hydrogen peroxide-induced oxidative stress can cause a ~twofold decrease in the number of lymphocytes secreting the TH1 cytokines IFN-gamma and IL-2, as well as chemokines IL-8 and TNF-alpha. Hydrogen Peroxide 13-30 interferon gamma Homo sapiens 143-152 22509110-5 2012 RESULTS: The levels of IL-6 and IFN-gamma in tear fluid in ocular GvHD patients were significantly elevated in comparison to patients without ocular GvHD and healthy controls (p<0.005 for each) The levels of IFN-gamma correlated with the Schirmer score (r=-0.48, p<0.0001) and tear break up time (TBUT; r=-0.38, p=0.03). tbut 303-307 interferon gamma Homo sapiens 211-220 22557874-3 2012 Indoleamine 2, 3-dioxygenase (IDO), the first rate-limiting enzyme in the tryptophan catabolism, is up regulated by interferon-gamma (IFN-g) which harbors single nucleotide polymorphisms (SNPs). Tryptophan 74-84 interferon gamma Homo sapiens 116-132 22487478-9 2012 IFN gamma resulted in 82.35% decrease in GSIR from the control islet cells at a concentration of >20 pg/ml which was reversed by epigallocatechin-3-gallate (EGCG). epigallocatechin gallate 132-158 interferon gamma Homo sapiens 0-9 22487478-9 2012 IFN gamma resulted in 82.35% decrease in GSIR from the control islet cells at a concentration of >20 pg/ml which was reversed by epigallocatechin-3-gallate (EGCG). epigallocatechin gallate 160-164 interferon gamma Homo sapiens 0-9 22557874-3 2012 Indoleamine 2, 3-dioxygenase (IDO), the first rate-limiting enzyme in the tryptophan catabolism, is up regulated by interferon-gamma (IFN-g) which harbors single nucleotide polymorphisms (SNPs). Tryptophan 74-84 interferon gamma Homo sapiens 134-139 23285304-13 2012 Moreover it suggests that in some HC production of IFN-gamma and CXCL10 are performed by cells not involved with DTH reaction. D-threonine 113-116 interferon gamma Homo sapiens 51-60 23272100-8 2012 The IL-2/IFN-gamma ratio in the antigen-stimulated plasma could discriminate LTBI from ATB with a sensitivity of 77.2% and a specificity of 87.2%. atb 87-90 interferon gamma Homo sapiens 9-18 23226309-0 2012 Oenothein B, a cyclic dimeric ellagitannin isolated from Epilobium angustifolium, enhances IFNgamma production by lymphocytes. oenothein B 0-11 interferon gamma Homo sapiens 91-99 23226309-6 2012 Furthermore, we demonstrate that oenothein B enhanced the production of IFNgamma by human T cells. oenothein B 33-44 interferon gamma Homo sapiens 72-80 23226309-7 2012 Since IFNgamma contributes to antitumor, antibacterial, and antiviral cell responses, these data suggest an additional mechanism that could account, at least in part, for the immune enhancing properties of oenothein B. oenothein B 206-217 interferon gamma Homo sapiens 6-14 23284753-9 2012 However, dmLT had variable influences on IFN-gamma responses to the different stimuli tested.Our demonstration of a potent ability of dmLT to enhance human Th17 type T cell responses to bacterial vaccine antigens encourages further evaluation of the adjuvant function of dmLT in humans. dmlt 134-138 interferon gamma Homo sapiens 41-50 23152847-8 2012 Aldosterone reduced the release of inflammatory mediators (6 and 24 hours: TNF-alpha, IFN-gamma, MIP-1alpha) in aqueous humor and the number of activated microglia/macrophages. Aldosterone 0-11 interferon gamma Homo sapiens 86-95 23284753-9 2012 However, dmLT had variable influences on IFN-gamma responses to the different stimuli tested.Our demonstration of a potent ability of dmLT to enhance human Th17 type T cell responses to bacterial vaccine antigens encourages further evaluation of the adjuvant function of dmLT in humans. dmlt 134-138 interferon gamma Homo sapiens 41-50 23152883-6 2012 rAaGroEL-responding CD4+ T cells expressed IL-10, IFNgamma and TNFalpha cytokines. raagroel 0-8 interferon gamma Homo sapiens 50-58 23185240-6 2012 AT-101-sensitized L3.6pl cells showed up-regulation of IFN-gamma-mediated induction in the phosphorylation of Ser(727)-Stat1 (pS(727)-Stat1), and IFN-gamma induced dephosphorylation of phospho-Tyr(705)-Stat3 (pY(705)-Stat3). Serine 110-113 interferon gamma Homo sapiens 55-64 23185240-6 2012 AT-101-sensitized L3.6pl cells showed up-regulation of IFN-gamma-mediated induction in the phosphorylation of Ser(727)-Stat1 (pS(727)-Stat1), and IFN-gamma induced dephosphorylation of phospho-Tyr(705)-Stat3 (pY(705)-Stat3). Serine 110-113 interferon gamma Homo sapiens 146-155 23185240-6 2012 AT-101-sensitized L3.6pl cells showed up-regulation of IFN-gamma-mediated induction in the phosphorylation of Ser(727)-Stat1 (pS(727)-Stat1), and IFN-gamma induced dephosphorylation of phospho-Tyr(705)-Stat3 (pY(705)-Stat3). Tyrosine 193-196 interferon gamma Homo sapiens 55-64 23185240-7 2012 Priming (conditioning) of PC cells with AT-101 can significantly enhance the anti-tumor activity of EGFRBi armed ATC through increased IFN-gamma induced activation of pS(727)-Stat1 and inhibition of pY(705)-Stat3 phosphorylation, and resulting in increased ratio of pro-apoptotic to anti-apoptotic proteins. gossypol acetic acid 40-46 interferon gamma Homo sapiens 135-144 23144765-7 2012 Despite the aberrant effect on CD25 expression, calcitriol increased the IL-10:IFNgamma ratio, characteristic of the CD46-induced Tr1 phenotype, in both T cells from healthy donors and patients with MS. Calcitriol 48-58 interferon gamma Homo sapiens 79-87 23110148-10 2012 Isoflavone treatment inhibited the ability of LPS-DCs to induce IFN-gamma in CD4+ T cells. Isoflavones 0-10 interferon gamma Homo sapiens 64-73 23091602-8 2012 Sitostanol increased production of IFNgamma by 6.5% and IL-2 by 6.0% compared to cholesterol (p<0.01). stigmastanol 0-10 interferon gamma Homo sapiens 35-43 23049677-9 2012 Although TNF-alpha is a major pro-inflammatory factor, IFN-gamma and three other cytokines have faster initial and median response to TGN1412 infusion. TGN-1412 134-141 interferon gamma Homo sapiens 55-64 23056446-9 2012 In the presence of anti-PD-L1, PGN induced secretion of IFN-gamma and IL-17 in total CCR6(+) cells, while nickel triggered secretion of IFN-gamma and IL-17 exclusively in CCR6(+)/CCR4(+) cells. Nickel 106-112 interferon gamma Homo sapiens 136-145 23071578-5 2012 The ratio between secreted IFN-gamma/IL-10 and IL-2/IL-10 was significantly lower in TB-IRIS patients in whom the cause of TB was a drug-resistant strain compared to those with a fully sensitive strain (p = 0.02). Terbium 85-87 interferon gamma Homo sapiens 27-36 23071578-5 2012 The ratio between secreted IFN-gamma/IL-10 and IL-2/IL-10 was significantly lower in TB-IRIS patients in whom the cause of TB was a drug-resistant strain compared to those with a fully sensitive strain (p = 0.02). Terbium 123-125 interferon gamma Homo sapiens 27-36 23028862-8 2012 The inhibition of NO production using the specific iNOS inhibitor 1400 W totally abolished the neurotoxic effect of LPS/IFN-gamma, suggesting a major role for NO in the neurotoxic effect of activated microglia. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 66-72 interferon gamma Homo sapiens 120-129 23028901-5 2012 Treatment with CsA completely blocked IFN-gamma production in DICs and inhibited TNF-alpha production in all examined cells. Cyclosporine 15-18 interferon gamma Homo sapiens 38-47 23028998-8 2012 Overall, we found that: 1) TSA alone and more so in combination with IFN-gamma enhanced both IRF-8 expression and Fas-mediated death of tumor cells in vitro; 2) TSA treatment enhanced IRF-8 promoter activity via a STAT1-dependent pathway; and 3) IRF-8 was required for this death response, as tumor cells rendered IRF-8 incompetent were significantly less susceptible to Fas-mediated killing in vitro and to HDACi-mediated antitumor activity in vivo. ammonium ferrous sulfate 114-117 interferon gamma Homo sapiens 69-78 23028998-8 2012 Overall, we found that: 1) TSA alone and more so in combination with IFN-gamma enhanced both IRF-8 expression and Fas-mediated death of tumor cells in vitro; 2) TSA treatment enhanced IRF-8 promoter activity via a STAT1-dependent pathway; and 3) IRF-8 was required for this death response, as tumor cells rendered IRF-8 incompetent were significantly less susceptible to Fas-mediated killing in vitro and to HDACi-mediated antitumor activity in vivo. trichostatin A 161-164 interferon gamma Homo sapiens 69-78 23029004-6 2012 The inhibitory effect of IFN-gamma on CTGF-expression could be almost completely compensated by the Jak inhibitor AG-490, showing the involvement of the Jak-Stat signaling pathway. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 114-120 interferon gamma Homo sapiens 25-34 22848715-4 2012 Ribavirin enhanced proliferation of T effector cells and increased production of IFN-gamma in TH1 clones, but had only little effect on IL-10 secretion in TH2 clones. Ribavirin 0-9 interferon gamma Homo sapiens 81-90 22844504-6 2012 In both models MC-12: reversed dose-dependently colonic inflammation; inhibited by up to 47% myeloperoxidase activity; had a minimal effect on cytoplasmic phospholipase A(2); reduced significantly the induced levels of TNF-alpha, IFN-gamma, IL-1beta, IL-6 and IL-10, returning them to baseline. mc-12 15-20 interferon gamma Homo sapiens 230-239 22624049-8 2012 Consequently, DCs matured in the presence of AMP and co-cultivated with naive CD4(+)CD45RA(+) T cells inhibited IFN-gamma production whereas secretion of IL-5 and IL-13 was up-regulated. Adenosine Monophosphate 45-48 interferon gamma Homo sapiens 112-121 22438887-6 2012 Amiloride enhanced development of full CD8 cytolytic function including induction of high levels of antigen specific CTL and expression of IFN-gamma+perforin+granzymeB+ in CD8+ T cells. Amiloride 0-9 interferon gamma Homo sapiens 139-148 22563434-4 2012 Significant increases in histone H3 lysine 27 trimethylation upon IFN-gamma stimulation correlate with reductions in transcription factor recruitment to the interferon-gamma inducible CIITA promoter, CIITApIV, and with significantly increased CIITApIV occupancy by the histone methyltransferase enhancer of zeste homolog 2 (EZH2). Lysine 36-42 interferon gamma Homo sapiens 66-75 22563434-4 2012 Significant increases in histone H3 lysine 27 trimethylation upon IFN-gamma stimulation correlate with reductions in transcription factor recruitment to the interferon-gamma inducible CIITA promoter, CIITApIV, and with significantly increased CIITApIV occupancy by the histone methyltransferase enhancer of zeste homolog 2 (EZH2). Lysine 36-42 interferon gamma Homo sapiens 157-173 22563434-4 2012 Significant increases in histone H3 lysine 27 trimethylation upon IFN-gamma stimulation correlate with reductions in transcription factor recruitment to the interferon-gamma inducible CIITA promoter, CIITApIV, and with significantly increased CIITApIV occupancy by the histone methyltransferase enhancer of zeste homolog 2 (EZH2). ciitapiv 200-208 interferon gamma Homo sapiens 66-75 22363706-4 2012 Nitric oxide is a chemical compound with pleiotropic functions; its production by phagocytes in response to interferon-gamma is associated with antimicrobial activity. Nitric Oxide 0-12 interferon gamma Homo sapiens 108-124 22253910-7 2012 We conclude that E. coli O157:H7 subverts Stat-1 tyrosine phosphorylation in response to interferon-gamma through a still as yet unidentified secreted bacterial protein. Tyrosine 49-57 interferon gamma Homo sapiens 89-105 23304497-3 2012 QuantiFERON-TB Gold In-Tube (QFT) assay conversion was defined as interferon-gamma concentrations <0.35 IU/mL at baseline and >=0.7 IU/mL at 18 months. tb gold 12-19 interferon gamma Homo sapiens 66-82 22355730-3 2012 PMA/ionomycin stimulated IFN-gamma+IL-2+TNF-alpha+ CD4 T cell responses were decreased in patients with smear-positive tuberculosis compared to those with smear-negative tuberculosis. Tetradecanoylphorbol Acetate 0-3 interferon gamma Homo sapiens 25-34 21912093-8 2012 RESULTS: Analytes sensitive to dithiothreitol (DTT) that had increased recovery in the 2-step sputum process were IL-1beta, 4, 5, 10, 13, IFN-gamma, TNFRI, GM-CSF, CCL2, 3, 4, 5, 13 and 17. Dithiothreitol 31-45 interferon gamma Homo sapiens 138-147 21912093-8 2012 RESULTS: Analytes sensitive to dithiothreitol (DTT) that had increased recovery in the 2-step sputum process were IL-1beta, 4, 5, 10, 13, IFN-gamma, TNFRI, GM-CSF, CCL2, 3, 4, 5, 13 and 17. Dithiothreitol 47-50 interferon gamma Homo sapiens 138-147 22536131-0 2012 Efficacy and safety of immunotherapy with interferon-gamma in the management of chronic sulfur mustard-induced cutaneous complications: comparison with topical betamethasone 1%. Mustard Gas 88-102 interferon gamma Homo sapiens 42-58 22536131-1 2012 The present trial investigated the efficacy of immunotherapy with interferon-gamma (IFN-gamma) in the treatment of sulfur mustard (SM)-induced chronic skin complications. Mustard Gas 115-129 interferon gamma Homo sapiens 66-82 22536131-1 2012 The present trial investigated the efficacy of immunotherapy with interferon-gamma (IFN-gamma) in the treatment of sulfur mustard (SM)-induced chronic skin complications. Mustard Gas 115-129 interferon gamma Homo sapiens 84-93 22355730-3 2012 PMA/ionomycin stimulated IFN-gamma+IL-2+TNF-alpha+ CD4 T cell responses were decreased in patients with smear-positive tuberculosis compared to those with smear-negative tuberculosis. Ionomycin 4-13 interferon gamma Homo sapiens 25-34 22536131-1 2012 The present trial investigated the efficacy of immunotherapy with interferon-gamma (IFN-gamma) in the treatment of sulfur mustard (SM)-induced chronic skin complications. Mustard Gas 131-133 interferon gamma Homo sapiens 66-82 22536131-1 2012 The present trial investigated the efficacy of immunotherapy with interferon-gamma (IFN-gamma) in the treatment of sulfur mustard (SM)-induced chronic skin complications. Mustard Gas 131-133 interferon gamma Homo sapiens 84-93 22355730-5 2012 Therefore, our findings argue against the notion that Mycobacterium tuberculosis antigen-specific multifunctional Th1 responses in peripheral blood can serve as correlates of protective immunity against tuberculosis; they suggest that the decrease in PMA/ionomycin stimulated IFN-gamma+IL-2+TNF-alpha+ CD4 T cells may be applied for clinical diagnosis of active tuberculosis. Ionomycin 255-264 interferon gamma Homo sapiens 276-285 22536131-7 2012 As for the magnitude of changes, treatment with IFN-gamma was associated with greater reductions in overall, objective and segmented SCORAD scores compared to betamethasone. Betamethasone 159-172 interferon gamma Homo sapiens 48-57 22536131-9 2012 Promising improvements in quality life and clinical symptoms that was observed in the present study suggest the application of IFN-gamma as an effective therapy for the management of SM-induced chronic skin complications. Mustard Gas 183-185 interferon gamma Homo sapiens 127-136 22003193-7 2012 Pulmonary exposure to 2% furfuryl alcohol resulted in enhanced airway hyperreactivity, eosinophilic infiltration into the lungs, and enhanced cytokine production (IL-4, IL-5, and interferon-gamma) by ex vivo stimulated lung-associated draining lymphoid cells. furfuryl alcohol 25-41 interferon gamma Homo sapiens 179-195 21745212-8 2012 CBaATCs exhibited peak specific interferon-gamma enzyme-linked immunosorbent spots on Day 10. cbaatcs 0-7 interferon gamma Homo sapiens 32-48 22195564-0 2011 Glycolipids that elicit IFN-gamma-biased responses from natural killer T cells. Glycolipids 0-11 interferon gamma Homo sapiens 24-33 22195564-2 2011 The first antigen described, alpha-galactosyl ceramide (alphaGalCer), is a potential anticancer agent whose activity depends upon IFN-gamma secretion. alpha-galactosylceramide 29-54 interferon gamma Homo sapiens 130-139 22027828-4 2011 When endothelial cells were treated with the HDAC3 inhibitor, apicidin, or shRNA-HDAC3 knockdown, IFN-gamma-induced galectin-9 expression was abolished. apicidin 62-70 interferon gamma Homo sapiens 98-107 22396896-2 2011 The key Th-1 type, pro-inflammatory cytokine, interferon-gamma (IFNG), transcriptionally induces the rate-limiting enzyme of tryptophan (TRY) - kynurenine (KYN) pathway, indoleamine 2,3- dioxygenase (IDO). Tryptophan 125-135 interferon gamma Homo sapiens 46-62 22018702-4 2011 1,25-dihydroxyvitamin D inhibited proliferation and suppressed secretion of IFN-gamma and IL-17, irrespective of T cell origin and HLA restriction. 1,25-dihydroxyvitamin D 0-23 interferon gamma Homo sapiens 76-85 22396896-2 2011 The key Th-1 type, pro-inflammatory cytokine, interferon-gamma (IFNG), transcriptionally induces the rate-limiting enzyme of tryptophan (TRY) - kynurenine (KYN) pathway, indoleamine 2,3- dioxygenase (IDO). Tryptophan 125-135 interferon gamma Homo sapiens 64-68 22396896-5 2011 Concurrently with activation of IDO, IFNG induces guanosine triphosphate cyclohydrolase I (GTPCH), the rate limiting enzyme of GTP conversion into BH2 (and increases formation of a stable derivative of BH2, neopterin, at the expense of production of BH4, the mandatory co-factor of NOS). bh2 147-150 interferon gamma Homo sapiens 37-41 22396896-5 2011 Concurrently with activation of IDO, IFNG induces guanosine triphosphate cyclohydrolase I (GTPCH), the rate limiting enzyme of GTP conversion into BH2 (and increases formation of a stable derivative of BH2, neopterin, at the expense of production of BH4, the mandatory co-factor of NOS). bh2 202-205 interferon gamma Homo sapiens 37-41 22396896-2 2011 The key Th-1 type, pro-inflammatory cytokine, interferon-gamma (IFNG), transcriptionally induces the rate-limiting enzyme of tryptophan (TRY) - kynurenine (KYN) pathway, indoleamine 2,3- dioxygenase (IDO). Kynurenine 144-154 interferon gamma Homo sapiens 46-62 22396896-5 2011 Concurrently with activation of IDO, IFNG induces guanosine triphosphate cyclohydrolase I (GTPCH), the rate limiting enzyme of GTP conversion into BH2 (and increases formation of a stable derivative of BH2, neopterin, at the expense of production of BH4, the mandatory co-factor of NOS). Neopterin 207-216 interferon gamma Homo sapiens 37-41 22396896-5 2011 Concurrently with activation of IDO, IFNG induces guanosine triphosphate cyclohydrolase I (GTPCH), the rate limiting enzyme of GTP conversion into BH2 (and increases formation of a stable derivative of BH2, neopterin, at the expense of production of BH4, the mandatory co-factor of NOS). sapropterin 250-253 interferon gamma Homo sapiens 37-41 22396896-2 2011 The key Th-1 type, pro-inflammatory cytokine, interferon-gamma (IFNG), transcriptionally induces the rate-limiting enzyme of tryptophan (TRY) - kynurenine (KYN) pathway, indoleamine 2,3- dioxygenase (IDO). Kynurenine 144-154 interferon gamma Homo sapiens 64-68 22396896-7 2011 Polymorphism of IFNG (+874) T/A gene, that encodes production of IFNG protein, impacts the IDO and GTPCH activity that might be assessed in humans by KYN/TRY ratio and neopterin concentrations in biological fluids (e.g., blood, urine and spinal fluid). Neopterin 168-177 interferon gamma Homo sapiens 16-20 22396896-2 2011 The key Th-1 type, pro-inflammatory cytokine, interferon-gamma (IFNG), transcriptionally induces the rate-limiting enzyme of tryptophan (TRY) - kynurenine (KYN) pathway, indoleamine 2,3- dioxygenase (IDO). Kynurenine 156-159 interferon gamma Homo sapiens 46-62 22396896-7 2011 Polymorphism of IFNG (+874) T/A gene, that encodes production of IFNG protein, impacts the IDO and GTPCH activity that might be assessed in humans by KYN/TRY ratio and neopterin concentrations in biological fluids (e.g., blood, urine and spinal fluid). Neopterin 168-177 interferon gamma Homo sapiens 65-69 22396896-2 2011 The key Th-1 type, pro-inflammatory cytokine, interferon-gamma (IFNG), transcriptionally induces the rate-limiting enzyme of tryptophan (TRY) - kynurenine (KYN) pathway, indoleamine 2,3- dioxygenase (IDO). Kynurenine 156-159 interferon gamma Homo sapiens 64-68 22396896-5 2011 Concurrently with activation of IDO, IFNG induces guanosine triphosphate cyclohydrolase I (GTPCH), the rate limiting enzyme of GTP conversion into BH2 (and increases formation of a stable derivative of BH2, neopterin, at the expense of production of BH4, the mandatory co-factor of NOS). Guanosine Triphosphate 91-94 interferon gamma Homo sapiens 37-41 21994461-8 2011 Following global stimulation with phorbol myristate acetate (PMA)-ionomycin, we noted a significant interleukin 2 (IL-2) deficit in both cervical and blood CD4 T cells from HIV-infected women compared to uninfected women, while gamma interferon (IFN-gamma) production was similar, irrespective of HIV status. Tetradecanoylphorbol Acetate 34-59 interferon gamma Homo sapiens 228-255 21983980-7 2011 The method was applied to analyze changes in tryptophan metabolism in cell culture supernatants from IFN-gamma-treated monocytes and immature or mature dendritic cells. Tryptophan 45-55 interferon gamma Homo sapiens 101-110 21749909-4 2011 Co-treatment of MM6 cells with IFN-gamma and cycloheximide caused a superinduction of SECTM1 mRNA expression while cycloheximide alone had no effect, illustrating that de novo protein synthesis is not required for IFN-gamma enhanced expression of SECTM1 mRNA, a characteristic of IFN early response genes. Cycloheximide 45-58 interferon gamma Homo sapiens 214-223 21749909-4 2011 Co-treatment of MM6 cells with IFN-gamma and cycloheximide caused a superinduction of SECTM1 mRNA expression while cycloheximide alone had no effect, illustrating that de novo protein synthesis is not required for IFN-gamma enhanced expression of SECTM1 mRNA, a characteristic of IFN early response genes. Cycloheximide 115-128 interferon gamma Homo sapiens 31-40 21998209-9 2011 Treatment with the proteasome inhibitor bortezomib reversed chemotherapy-induced STAT4 deficiency and defective IFN-gamma production. Bortezomib 40-50 interferon gamma Homo sapiens 112-121 21890376-7 2011 It was found that YC-1 attenuated barrier dysfunction caused by IFN-gamma and TNF-alpha, and also prevented IFN-gamma and TNF-alpha-induced morphological redistribution of tight junction proteins ZO-1 and occludin in Caco-2 monolayers. caco-2 217-223 interferon gamma Homo sapiens 108-117 22001396-3 2011 Then, we analyzed the effects of BA treatment on the mRNA expression of Toll-like receptors (TLRs), IL-2, IFN-gamma and IL-12 in T and B cells by real-time RT-PCR and attempted to observe whether blocking TLR4 had influence on mRNA expression. baicalin 33-35 interferon gamma Homo sapiens 106-115 22001396-4 2011 We found that BA treatment significantly up-regulated TLR3, 7, 8 and 9 mRNA expressions in T and B cells, IL-2 and IFN-gamma in T cells and IL-12 in B cells. baicalin 14-16 interferon gamma Homo sapiens 115-124 21994461-8 2011 Following global stimulation with phorbol myristate acetate (PMA)-ionomycin, we noted a significant interleukin 2 (IL-2) deficit in both cervical and blood CD4 T cells from HIV-infected women compared to uninfected women, while gamma interferon (IFN-gamma) production was similar, irrespective of HIV status. Tetradecanoylphorbol Acetate 61-64 interferon gamma Homo sapiens 228-255 21994461-8 2011 Following global stimulation with phorbol myristate acetate (PMA)-ionomycin, we noted a significant interleukin 2 (IL-2) deficit in both cervical and blood CD4 T cells from HIV-infected women compared to uninfected women, while gamma interferon (IFN-gamma) production was similar, irrespective of HIV status. Ionomycin 66-75 interferon gamma Homo sapiens 228-255 21501686-8 2011 The tetracyclines appear to target T cell pathways to induce suppression of IgE responses because they suppress phos p38 MAP kinase expression by both CD4+ and CD8+, including CD8+CD60+, T cell subsets, and IL-4 and IL-10, while upregulating IL-2 and IFN gamma, and suppressing IgE responses. Tetracyclines 4-17 interferon gamma Homo sapiens 251-260 22032897-8 2011 Our data suggest that dydrogesterone treatment of women at risk of preterm delivery results in increased PIBF production and IL-10 concentrations, and lower concentrations of IFNgamma. Dydrogesterone 22-36 interferon gamma Homo sapiens 175-183 22192260-6 2011 However, CAPE significantly decreased IL-10 and interferon-gamma in healthy donors. caffeic acid phenethyl ester 9-13 interferon gamma Homo sapiens 48-64 21911248-6 2011 Further, IL-18BPa/Fc enhanced dexamethason(DEX) reduction of PHA-induced IFN-gamma production by an additional 38.9%(DEX 20 nmol/l) and 49.9%(DEX 50 nmol/l) in ITP patients. Dexamethasone 30-42 interferon gamma Homo sapiens 73-82 21911248-6 2011 Further, IL-18BPa/Fc enhanced dexamethason(DEX) reduction of PHA-induced IFN-gamma production by an additional 38.9%(DEX 20 nmol/l) and 49.9%(DEX 50 nmol/l) in ITP patients. Dextromethorphan 43-46 interferon gamma Homo sapiens 73-82 21992896-0 2011 Salvianolic acid B suppresses IFN-gamma-induced JAK/STAT1 activation in endothelial cells. salvianolic acid B 0-18 interferon gamma Homo sapiens 30-39 21992896-3 2011 METHODS AND RESULTS: Sal B pretreatment significantly inhibited the IFN-gamma-induced phosphorylations of JAK2 (Tyr 1007/1008) and STAT1 (Tyr701 and Ser727). salvianolic acid B 21-26 interferon gamma Homo sapiens 68-77 21992896-3 2011 METHODS AND RESULTS: Sal B pretreatment significantly inhibited the IFN-gamma-induced phosphorylations of JAK2 (Tyr 1007/1008) and STAT1 (Tyr701 and Ser727). Tyrosine 112-115 interferon gamma Homo sapiens 68-77 21992896-4 2011 Consistently, IFN-gamma-induced STAT1 downstream targets CXC chemokines" IP-10, Mig, and I-TAC were suppressed by Sal B pretreatment. salvianolic acid B 114-119 interferon gamma Homo sapiens 14-23 21992896-6 2011 The monocyte adhesion to IFN-gamma-treated ECs was observed to be reduced after Sal B pretreatment. salvianolic acid B 80-85 interferon gamma Homo sapiens 25-34 21992896-8 2011 CONCLUSIONS: The anti-inflammatory properties of Sal B on IFN-gamma-induced JAK-STAT1 activation were demonstrated in the present study which provides a molecular basis for possible therapeutic usage on vascular disorders. salvianolic acid B 49-54 interferon gamma Homo sapiens 58-67 22111595-5 2011 We found that interferon-gamma (IFN-gamma) production in response to CMV-infected fibroblasts was reduced under the influence of MG132 in a dose-dependent manner. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 129-134 interferon gamma Homo sapiens 14-30 22111595-5 2011 We found that interferon-gamma (IFN-gamma) production in response to CMV-infected fibroblasts was reduced under the influence of MG132 in a dose-dependent manner. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 129-134 interferon gamma Homo sapiens 32-41 22006409-3 2011 A TB network for company doctors was created when interferon-gamma release assays (IGRAs) were introduced in order to systematically collate their experience with IGRAs in preventive check-ups. Terbium 2-4 interferon gamma Homo sapiens 50-66 22373344-0 2011 Effect of iron sources on the glycosylation macroheterogeneity of human recombinant IFN-gamma produced by CHO cells during batch processes. Iron 10-14 interferon gamma Homo sapiens 84-93 21989990-7 2011 IFN-gamma secretion induced by NKp46 engagement was inhibited by NKG2A engagement in untreated but not in sHLA-G-treated NK cells. shla-g 106-112 interferon gamma Homo sapiens 0-9 22113581-0 2011 A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-gamma/LPS-stimulated macrophages. Curcumin 2-10 interferon gamma Homo sapiens 167-176 22113581-0 2011 A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-gamma/LPS-stimulated macrophages. 2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone 23-70 interferon gamma Homo sapiens 167-176 22113581-0 2011 A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-gamma/LPS-stimulated macrophages. 2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone 72-78 interferon gamma Homo sapiens 167-176 22113581-0 2011 A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-gamma/LPS-stimulated macrophages. Dinoprostone 91-107 interferon gamma Homo sapiens 167-176 22373384-0 2011 Characterization of metalloprotease and serine protease activities in batch CHO cell cultures: control of human recombinant IFN-gamma proteolysis by addition of iron citrate. ferric citrate 161-173 interferon gamma Homo sapiens 124-133 22113581-5 2011 In addition, BDMC33 modulates the COX expression by sustaining the constitutively COX-1 expression in IFN-gamma/LPS-treated macrophage cells. 2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone 13-19 interferon gamma Homo sapiens 102-111 21972293-3 2011 Exogenous PGE(2) and such diverse COX2 activators as lipopolysaccharide, IL-1beta, and IFNgamma all induce monocyte expression of COX2, blocking their differentiation into CD1a(+) DCs and inducing endogenous PGE(2), IDO1, IL-4Ralpha, NOS2, and IL-10, typical MDSC-associated suppressive factors. Prostaglandins E 208-211 interferon gamma Homo sapiens 87-95 22015556-7 2011 Increased cell surface expression of MHC class I cell molecules, associated with upregulation of the antigen-presenting machinery-related genes, as well as of genes encoding selected components of the IFNgamma-signalling pathway in tumours explanted from 5AC-treated animals, were observed. Azacitidine 255-258 interferon gamma Homo sapiens 201-209 21964192-10 2011 RESULTS: Using mixed leukocytes reaction we demonstrated for the first time that both Art-C and PBrazil significantly inhibited the alloreactive CD4 T cell proliferation, activation, and suppressed the expressions of IL-2, IFN-gamma and IL-17 in these alloreactive CD4 T cells. pbrazil 96-103 interferon gamma Homo sapiens 223-232 21972293-3 2011 Exogenous PGE(2) and such diverse COX2 activators as lipopolysaccharide, IL-1beta, and IFNgamma all induce monocyte expression of COX2, blocking their differentiation into CD1a(+) DCs and inducing endogenous PGE(2), IDO1, IL-4Ralpha, NOS2, and IL-10, typical MDSC-associated suppressive factors. Prostaglandins E 10-13 interferon gamma Homo sapiens 87-95 22013115-7 2011 Notably, resolvin D1, an anti-inflammatory and proresolving mediator biosynthesized from DHA, markedly attenuated IFN-gamma/LPS-induced Th1 cytokines while upregulating arginase 1 expression in a concentration-dependent manner. Docosahexaenoic Acids 89-92 interferon gamma Homo sapiens 114-123 22024742-4 2011 Therefore, we reasoned that the therapeutic properties of H-1PV can be boosted with IFNgamma for the treatment of late incurable stages of PDAC like peritoneal carcinomatosis. pdac 139-143 interferon gamma Homo sapiens 84-92 22051322-11 2011 RESULTS: In macrophages and PBL, RHP and GLGPG inhibited NO and PGE(2) production and reduced the secretion of cytokines (TNF-alpha, IFN-gamma, IL-1beta, IL-6, IL-12) and chemokines (CCL5/RANTES, CXCL10/IP-10). glgpg 41-46 interferon gamma Homo sapiens 133-142 21953703-8 2011 Raw 264.7 macrophages were loaded with the DAA or DAA-TZ under conditions of no-stimulation or stimulation with interferon-gamma and lipopolysaccharide to produce NO. 1,2-diaminoanthraquinone 43-46 interferon gamma Homo sapiens 112-128 21953703-8 2011 Raw 264.7 macrophages were loaded with the DAA or DAA-TZ under conditions of no-stimulation or stimulation with interferon-gamma and lipopolysaccharide to produce NO. daa-tz 50-56 interferon gamma Homo sapiens 112-128 22011961-5 2011 The aim of this study was to evaluate the ability of pentoxifylline, forskolin, rolipram, and thalidomide to decrease in vitro production of TNF-alpha and IFN-gamma in cells of HTLV-1-infected subjects. Pentoxifylline 53-67 interferon gamma Homo sapiens 155-164 22011961-5 2011 The aim of this study was to evaluate the ability of pentoxifylline, forskolin, rolipram, and thalidomide to decrease in vitro production of TNF-alpha and IFN-gamma in cells of HTLV-1-infected subjects. Colforsin 69-78 interferon gamma Homo sapiens 155-164 22011961-5 2011 The aim of this study was to evaluate the ability of pentoxifylline, forskolin, rolipram, and thalidomide to decrease in vitro production of TNF-alpha and IFN-gamma in cells of HTLV-1-infected subjects. Rolipram 80-88 interferon gamma Homo sapiens 155-164 22011961-5 2011 The aim of this study was to evaluate the ability of pentoxifylline, forskolin, rolipram, and thalidomide to decrease in vitro production of TNF-alpha and IFN-gamma in cells of HTLV-1-infected subjects. Thalidomide 94-105 interferon gamma Homo sapiens 155-164 22011961-8 2011 Pentoxifylline inhibited TNF-alpha and IFN-gamma synthesis with the minimum dose used (50 microM). Pentoxifylline 0-14 interferon gamma Homo sapiens 39-48 22011961-10 2011 The doses of rolipram used were 0.01-1 microM and the best inhibition of TNF-alpha production was achieved with 1 microM and for IFN-gamma production it was 0.01 microM. Rolipram 13-21 interferon gamma Homo sapiens 129-138 22011961-12 2011 All drugs had an in vitro inhibitory effect on TNF-alpha production and, with the exception of thalidomide, all of them also decreased IFN-gamma production. Thalidomide 95-106 interferon gamma Homo sapiens 135-144 21955625-7 2011 Among children with ETB, those with neurologic involvement exhibited more significantly diminished Ag-driven IFN-gamma and IL-17 production. etb 20-23 interferon gamma Homo sapiens 109-118 22133036-3 2011 MTX reduces the production of pro-inflammatory cytokines such as interleukin (IL)-1, IL-2, IL-6 and interferon (INF)-gamma, while the gene expression of anti-inflammatory Th2 cytokines like IL-4 and IL-10 is increased - altogether resulting in the anti-inflammatory effect. Methotrexate 0-3 interferon gamma Homo sapiens 100-122 21795061-7 2011 Ketamine and MK-801 decreased TH1 cells, TH2 cells, IFN-gamma and IL-4 levels but increased the ratio of TH1/TH2 and IFN-gamma/IL-4 in the presence of PMA and ionomycin. Tetradecanoylphorbol Acetate 151-154 interferon gamma Homo sapiens 117-126 21795061-7 2011 Ketamine and MK-801 decreased TH1 cells, TH2 cells, IFN-gamma and IL-4 levels but increased the ratio of TH1/TH2 and IFN-gamma/IL-4 in the presence of PMA and ionomycin. Ionomycin 159-168 interferon gamma Homo sapiens 117-126 21795061-6 2011 TH1 cells, TH2 cells, IFN-gamma and IL-4 levels were significantly increased after PMA and ionomycin stimulation. Ionomycin 91-100 interferon gamma Homo sapiens 22-31 21905954-10 2011 The increase of PGE2 was associated with a significant decrease of pro-inflammatory cytokine levels (interferon-gamma and tumor necrosis-alpha), while no changes in levels of interleukin-10, soluble HLA-G and nitric oxide were observed. Dinoprostone 16-20 interferon gamma Homo sapiens 101-142 21795061-7 2011 Ketamine and MK-801 decreased TH1 cells, TH2 cells, IFN-gamma and IL-4 levels but increased the ratio of TH1/TH2 and IFN-gamma/IL-4 in the presence of PMA and ionomycin. Ketamine 0-8 interferon gamma Homo sapiens 52-61 21795061-7 2011 Ketamine and MK-801 decreased TH1 cells, TH2 cells, IFN-gamma and IL-4 levels but increased the ratio of TH1/TH2 and IFN-gamma/IL-4 in the presence of PMA and ionomycin. Ketamine 0-8 interferon gamma Homo sapiens 117-126 21795061-7 2011 Ketamine and MK-801 decreased TH1 cells, TH2 cells, IFN-gamma and IL-4 levels but increased the ratio of TH1/TH2 and IFN-gamma/IL-4 in the presence of PMA and ionomycin. Dizocilpine Maleate 13-19 interferon gamma Homo sapiens 52-61 21795061-7 2011 Ketamine and MK-801 decreased TH1 cells, TH2 cells, IFN-gamma and IL-4 levels but increased the ratio of TH1/TH2 and IFN-gamma/IL-4 in the presence of PMA and ionomycin. Dizocilpine Maleate 13-19 interferon gamma Homo sapiens 117-126 21854775-1 2011 In interferon-gamma activated human macrophages, GTP-cyclohydrolase 1 catalyses the conversion of guanosine triphosphate to 7,8-dihydroneopterin triphosphate, which is dephosphorylated and oxidized to form neopterin. Guanosine Triphosphate 98-120 interferon gamma Homo sapiens 3-19 21630032-6 2011 Bezafibrate treatment was associated with a reduction in lymphocyte release of interleukin-2, interferon-gamma and tumor necrosis factor-alpha, which was accompanied by a reduction in plasma hsCRP levels. Bezafibrate 0-11 interferon gamma Homo sapiens 94-142 21854775-1 2011 In interferon-gamma activated human macrophages, GTP-cyclohydrolase 1 catalyses the conversion of guanosine triphosphate to 7,8-dihydroneopterin triphosphate, which is dephosphorylated and oxidized to form neopterin. dihydroneopterin triphosphate 124-157 interferon gamma Homo sapiens 3-19 21854775-1 2011 In interferon-gamma activated human macrophages, GTP-cyclohydrolase 1 catalyses the conversion of guanosine triphosphate to 7,8-dihydroneopterin triphosphate, which is dephosphorylated and oxidized to form neopterin. Neopterin 135-144 interferon gamma Homo sapiens 3-19 21839858-5 2011 Subsequently, over-expression of HMBOX1 significantly inhibited the expression and production of IFN-gamma in NK cells in response to the stimulation of tumor cell K562 or PMA/ionomycin. Tetradecanoylphorbol Acetate 172-175 interferon gamma Homo sapiens 97-106 21835268-0 2011 IFN-gamma and TNF-alpha potentiate prostaglandin D2-induced human eosinophil chemotaxis through up-regulation of CRTH2 surface receptor. Prostaglandin D2 35-51 interferon gamma Homo sapiens 0-9 21835268-5 2011 PGD2 exhibited a typical bell shape dose response in attracting eosinophil from AR patients with optimal activity at 10(-7) M. Eol-1 cell surface expression of CRTH2 was significantly up-regulated by 10 ng/ml IFN-gamma and TNF-alpha. Prostaglandin D2 0-4 interferon gamma Homo sapiens 209-218 21835268-8 2011 PGD2-induced Eol-1 chemotaxis was potentiated by IFN-gamma and TNF-alpha without changing the signal transduction pathway. Prostaglandin D2 0-4 interferon gamma Homo sapiens 49-58 21835268-9 2011 Correlation of our results to peripheral blood eosinophils from allergic rhinitis patients confirmed that 3 hour pretreatment of eosinophils by 10 ng/ml IFN-gamma and TNF-alpha, increased the mean fluorescence intensity (MFI) of CRTH2 from 8.23 to 9.68 and 9.38, respectively, and potentiated PGD2-induced eosinophil chemotaxis. Prostaglandin D2 293-297 interferon gamma Homo sapiens 153-162 21839858-5 2011 Subsequently, over-expression of HMBOX1 significantly inhibited the expression and production of IFN-gamma in NK cells in response to the stimulation of tumor cell K562 or PMA/ionomycin. Ionomycin 176-185 interferon gamma Homo sapiens 97-106 21911470-1 2011 Gamma interferon (IFN-gamma) induces expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) in human epithelial cells, the permissive cells for the obligate intracellular bacterium Chlamydia trachomatis. Tryptophan 55-65 interferon gamma Homo sapiens 0-27 21433155-0 2011 Triptolide inhibits IFN-gamma signaling via the Jak/STAT pathway in HaCaT keratinocytes. triptolide 0-10 interferon gamma Homo sapiens 20-29 21911470-4 2011 Here, we tested the effects of the IDO1 inhibitor, levo-1-methyl-tryptophan (L-1MT), on IFN-gamma-induced C. trachomatis persistence. levo-1-methyl-tryptophan 51-75 interferon gamma Homo sapiens 88-97 21911470-4 2011 Here, we tested the effects of the IDO1 inhibitor, levo-1-methyl-tryptophan (L-1MT), on IFN-gamma-induced C. trachomatis persistence. l-1mt 77-82 interferon gamma Homo sapiens 88-97 21911470-9 2011 IFN-gamma-induced persistent infections in epithelial cells have been previously reported to be more resistant to doxycycline than normal productive infections in vitro. Doxycycline 114-125 interferon gamma Homo sapiens 0-9 22295566-2 2011 The results show evidence for the contribution of polymorphic variants in CCRS, DRB1, IFNG, TGFB1, IFNAR1, IL7RA and, probably, TNF and CTLA4 genes to copaxone treatment response. Glatiramer Acetate 151-159 interferon gamma Homo sapiens 86-90 21433155-13 2011 This study suggests that triptolide may contribute to the therapeutic value of T. wilfordii by modulating the IFN-gamma signal pathway in IFN-gamma-dependent skin inflammatory diseases, including psoriasis. triptolide 25-35 interferon gamma Homo sapiens 110-119 21433155-13 2011 This study suggests that triptolide may contribute to the therapeutic value of T. wilfordii by modulating the IFN-gamma signal pathway in IFN-gamma-dependent skin inflammatory diseases, including psoriasis. triptolide 25-35 interferon gamma Homo sapiens 138-147 21788064-0 2011 Reduced production of IFN-gamma and LT-alpha is associated with successful prednisone therapy in patients with acquired hemophilia A: a pilot study. Prednisone 75-85 interferon gamma Homo sapiens 22-31 21788064-7 2011 The amount of IFN-gamma and LT-alpha were markedly reduced by the time of inhibitor disappearance in the patients responding to GC therapy but remained high in the non-responder until cyclophosphamide was added. Cyclophosphamide 184-200 interferon gamma Homo sapiens 14-23 21788064-8 2011 This study suggests that the secretion level of IFN-gamma and/or LT-alpha could be a predictive marker of prednisone responsiveness. Prednisone 106-116 interferon gamma Homo sapiens 48-57 21763349-2 2011 Our previous studies have shown that risperidone and clozapine effectively decrease the production of IFN-gamma for CD4(+) T-cells in PBMC. Risperidone 37-48 interferon gamma Homo sapiens 102-111 21763349-2 2011 Our previous studies have shown that risperidone and clozapine effectively decrease the production of IFN-gamma for CD4(+) T-cells in PBMC. Clozapine 53-62 interferon gamma Homo sapiens 102-111 21763349-3 2011 In contrast, haloperidol causes an increase in the production of IFN-gamma for CD4(+) T-cells in PBMC. Haloperidol 13-24 interferon gamma Homo sapiens 65-74 21763349-8 2011 In addition, chronic risperidone and clozapine treatment reduces the IFN-gamma producing CD4(+) T-cell population within PBMC. Risperidone 21-32 interferon gamma Homo sapiens 69-78 21763349-8 2011 In addition, chronic risperidone and clozapine treatment reduces the IFN-gamma producing CD4(+) T-cell population within PBMC. Clozapine 37-46 interferon gamma Homo sapiens 69-78 21936496-4 2011 Chlorogenic acid and caffeic acid also increased the number of IFN-gamma(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-gamma(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. Chlorogenic Acid 0-16 interferon gamma Homo sapiens 63-72 21936496-4 2011 Chlorogenic acid and caffeic acid also increased the number of IFN-gamma(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-gamma(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. caffeic acid 21-33 interferon gamma Homo sapiens 63-72 21936496-4 2011 Chlorogenic acid and caffeic acid also increased the number of IFN-gamma(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-gamma(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. Polyphenols 114-125 interferon gamma Homo sapiens 150-159 21936496-5 2011 On the other hand, a 70% ethanol-insoluble date extract treated with trypsin increased the number of IFN-gamma(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. Ethanol 25-32 interferon gamma Homo sapiens 101-110 21357438-8 2011 These findings show reduction of antitumor immune function in asbestos-exposed patients and indicate that CXCR3, IFN-gamma, and CXCL10/IP10 may be candidates to detect and monitor disease status. Asbestos 62-70 interferon gamma Homo sapiens 113-122 21998409-0 2011 Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Vitamin D 0-9 interferon gamma Homo sapiens 26-35 21998409-3 2011 We report that T cells, by the release of interferon-gamma (IFN-gamma), induce autophagy, phagosomal maturation, the production of antimicrobial peptides such as cathelicidin, and antimicrobial activity against Mycobacterium tuberculosis in human macrophages via a vitamin D-dependent pathway. Vitamin D 265-274 interferon gamma Homo sapiens 60-69 21998409-4 2011 IFN-gamma induced the antimicrobial pathway in human macrophages cultured in vitamin D-sufficient sera, but not in sera from African-Americans that have lower amounts of vitamin D and who are more susceptible to tuberculosis. Vitamin D 77-86 interferon gamma Homo sapiens 0-9 21998409-5 2011 In vitro supplementation of vitamin D-deficient serum with 25-hydroxyvitamin D3 restored IFN-gamma-induced antimicrobial peptide expression, autophagy, phagosome-lysosome fusion, and antimicrobial activity. Vitamin D 28-37 interferon gamma Homo sapiens 89-98 21998409-5 2011 In vitro supplementation of vitamin D-deficient serum with 25-hydroxyvitamin D3 restored IFN-gamma-induced antimicrobial peptide expression, autophagy, phagosome-lysosome fusion, and antimicrobial activity. Calcifediol 59-79 interferon gamma Homo sapiens 89-98 21800888-6 2011 Subsequently, IFNgamma was conjugated to PPB-HSA via bifunctional PEG linkers to synthesize PPB-HSA-PEG-IFNgamma. ppb-hsa 41-48 interferon gamma Homo sapiens 14-22 21800888-6 2011 Subsequently, IFNgamma was conjugated to PPB-HSA via bifunctional PEG linkers to synthesize PPB-HSA-PEG-IFNgamma. ppb-hsa 41-48 interferon gamma Homo sapiens 104-112 21800888-6 2011 Subsequently, IFNgamma was conjugated to PPB-HSA via bifunctional PEG linkers to synthesize PPB-HSA-PEG-IFNgamma. Polyethylene Glycols 66-69 interferon gamma Homo sapiens 14-22 21800888-6 2011 Subsequently, IFNgamma was conjugated to PPB-HSA via bifunctional PEG linkers to synthesize PPB-HSA-PEG-IFNgamma. Polyethylene Glycols 66-69 interferon gamma Homo sapiens 104-112 21800888-6 2011 Subsequently, IFNgamma was conjugated to PPB-HSA via bifunctional PEG linkers to synthesize PPB-HSA-PEG-IFNgamma. ppb-hsa 92-99 interferon gamma Homo sapiens 14-22 21800888-6 2011 Subsequently, IFNgamma was conjugated to PPB-HSA via bifunctional PEG linkers to synthesize PPB-HSA-PEG-IFNgamma. ppb-hsa 92-99 interferon gamma Homo sapiens 104-112 21800888-6 2011 Subsequently, IFNgamma was conjugated to PPB-HSA via bifunctional PEG linkers to synthesize PPB-HSA-PEG-IFNgamma. Polyethylene Glycols 100-103 interferon gamma Homo sapiens 14-22 21800888-6 2011 Subsequently, IFNgamma was conjugated to PPB-HSA via bifunctional PEG linkers to synthesize PPB-HSA-PEG-IFNgamma. Polyethylene Glycols 100-103 interferon gamma Homo sapiens 104-112 21800888-7 2011 In vitro, PPB-HSA-PEG-IFNgamma retained complete biological activity similar to unmodified IFNgamma and showed PDGFbetaR-specific binding to human HSC and primary culture-activated rat HSC. ppb-hsa-peg 10-21 interferon gamma Homo sapiens 22-30 21800888-12 2011 In conclusion, these data demonstrate the enhanced antifibrotic efficacy and reduced off-target effects of PPB-HSA-PEG-IFNgamma conjugate showing the potential of cell-specific targeting of IFNgamma for the treatment of liver fibrosis. ppb-hsa-peg 107-118 interferon gamma Homo sapiens 119-127 21800888-12 2011 In conclusion, these data demonstrate the enhanced antifibrotic efficacy and reduced off-target effects of PPB-HSA-PEG-IFNgamma conjugate showing the potential of cell-specific targeting of IFNgamma for the treatment of liver fibrosis. ppb-hsa-peg 107-118 interferon gamma Homo sapiens 190-198 21712539-2 2011 Recently, we have shown that neu-trophils amplify NK cell/6-sulfo LacNAc(+) dendritic cells (slanDC)-mediated cytokine production, by potentiating IL-12p70 release by slanDC via CD18/ICAM-1 and directly co-stimulating IFNgamma production by NK cells via ICAM-3. 6-sulfo-LacNac 58-72 interferon gamma Homo sapiens 218-226 21912249-8 2011 Their IFN-gamma stimulates intestinal macrophages to produce nitirc oxide paralyzing myocytes leading to gastrointestinal hypomotility. nitirc oxide 61-73 interferon gamma Homo sapiens 6-15 22256408-5 2011 Subjects diagnosed as latent TB infection by IFN-gamma assay (QuantiFERON-TB Gold In-Tube) were 5.9% of controls, 31.0% of casual contacts and 33.3% of close contacts. Terbium 74-76 interferon gamma Homo sapiens 45-54 21413978-0 2011 Predictors of indeterminate IFN-gamma release assay in screening for latent TB in inflammatory bowel diseases. Terbium 76-78 interferon gamma Homo sapiens 28-37 21821246-12 2011 EGCG down-regulated VEGFC/VEGFR2 signaling through c-JUN, interferon-gamma, matrix metalloproteinase 9, and chemokine (C-X-C motif) ligand 3 pathways for endothelial proliferation, inflammatory response, and mobility. epigallocatechin gallate 0-4 interferon gamma Homo sapiens 58-74 21712539-2 2011 Recently, we have shown that neu-trophils amplify NK cell/6-sulfo LacNAc(+) dendritic cells (slanDC)-mediated cytokine production, by potentiating IL-12p70 release by slanDC via CD18/ICAM-1 and directly co-stimulating IFNgamma production by NK cells via ICAM-3. slandc 93-99 interferon gamma Homo sapiens 218-226 21712539-4 2011 More specifically, we provide evidence that: i) the cross-talk between neutrophils and NK cells is mediated by ICAM-3 and CD11d/CD18, respectively; ii) slanDC potentiate the production of IFNgamma by NK cells via CD11a/CD18. slandc 152-158 interferon gamma Homo sapiens 188-196 21635971-7 2011 The results showed that PGE2 inhibited IFN-gamma, TNF-alpha and IL-4 production by CD4+ T cells 24h after cell culture. Dinoprostone 24-28 interferon gamma Homo sapiens 39-48 21635971-8 2011 A comparison between IFN-gamma and IL-4 production showed that PGE2 enhanced the relative ratio of IL-4 to IFN-gamma in CD4+ T cells culture, and regulated CD4+ T cells toward Th2 cell development. Dinoprostone 63-67 interferon gamma Homo sapiens 21-30 21635971-8 2011 A comparison between IFN-gamma and IL-4 production showed that PGE2 enhanced the relative ratio of IL-4 to IFN-gamma in CD4+ T cells culture, and regulated CD4+ T cells toward Th2 cell development. Dinoprostone 63-67 interferon gamma Homo sapiens 107-116 21189227-6 2011 Moreover, resveratrol diminished IFN-gamma-induced protein levels of inducible NO synthase (iNOS), attenuated mRNA levels of iNOS, IP-10 or MIG as well as inhibited IFN-gamma-induced promoter activity of iNOS gene, indicating that the phytoalexin could down-regulate inflammatory genes at the transcription level. Resveratrol 10-21 interferon gamma Homo sapiens 165-174 21792205-4 2011 Ganodermycin inhibited the lipopolysaccharide (LPS)/interferon (IFN)-gamma-induced CXCL10 promoter activity in transiently transfected MonoMac6 cells in a dose-dependent manner with IC(50) values of 15-20 mug ml(-1) (53-71 muM). Ganodermycin 0-12 interferon gamma Homo sapiens 52-74 21189227-0 2011 Resveratrol down-regulates interferon-gamma-inducible inflammatory genes in macrophages: molecular mechanism via decreased STAT-1 activation. Resveratrol 0-11 interferon gamma Homo sapiens 27-43 21189227-4 2011 In this study, we investigated effects of resveratrol on inflammatory gene expression in interferon (IFN)-gamma alone-stimulated macrophages and proposed a molecular basis underlying the action. Resveratrol 42-53 interferon gamma Homo sapiens 89-111 21189227-7 2011 To understand a mechanism of the action, we tested resveratrol could affect the signal transducers and activation of transcription-1 (STAT-1), a pivotal transcription factor in IFN-gamma-induced expression of inflammatory genes. Resveratrol 51-62 interferon gamma Homo sapiens 177-186 21189227-6 2011 Moreover, resveratrol diminished IFN-gamma-induced protein levels of inducible NO synthase (iNOS), attenuated mRNA levels of iNOS, IP-10 or MIG as well as inhibited IFN-gamma-induced promoter activity of iNOS gene, indicating that the phytoalexin could down-regulate inflammatory genes at the transcription level. Resveratrol 10-21 interferon gamma Homo sapiens 33-42 21189227-8 2011 Resveratrol inhibited IFN-gamma-induced transcriptional activity of STAT-1 in macrophages and also IFN-gamma-induced Tyr(701) or Ser(727) phosphorylation of STAT-1. Resveratrol 0-11 interferon gamma Homo sapiens 22-31 21189227-8 2011 Resveratrol inhibited IFN-gamma-induced transcriptional activity of STAT-1 in macrophages and also IFN-gamma-induced Tyr(701) or Ser(727) phosphorylation of STAT-1. Resveratrol 0-11 interferon gamma Homo sapiens 99-108 21189227-8 2011 Resveratrol inhibited IFN-gamma-induced transcriptional activity of STAT-1 in macrophages and also IFN-gamma-induced Tyr(701) or Ser(727) phosphorylation of STAT-1. Tyrosine 117-120 interferon gamma Homo sapiens 99-108 21189227-10 2011 Resveratrol inhibited IFN-gamma-induced activation of Janus kinase-2 (JAK-2) and also the extracellular signal-regulated kinase, in which JAK-2 was more sensitive. Resveratrol 0-11 interferon gamma Homo sapiens 22-31 21189227-11 2011 Taken together, this study proposes a new mechanism of resveratrol, blocking JAK/STAT-1 pathway that controls inflammatory responses in IFN-gamma-activated macrophages. Resveratrol 55-66 interferon gamma Homo sapiens 136-145 21658766-3 2011 We show that PBMCs stimulated with allogeneic cells and treated with bortezomib greatly reduce their ability to produce IFN-gamma when re-stimulated with the same allogeneic cells, but mainly preserve their ability to respond to citomegalovirus stimulation. Bortezomib 69-79 interferon gamma Homo sapiens 120-129 21979989-7 2011 OCT inhibited PBMC proliferation in a dose-dependent manner and decreased the secretion of interleukin-6 (IL-6), interleukin-10 (IL-10), and interferon-gamma (IFN-gamma). Octreotide 0-3 interferon gamma Homo sapiens 141-157 21979989-7 2011 OCT inhibited PBMC proliferation in a dose-dependent manner and decreased the secretion of interleukin-6 (IL-6), interleukin-10 (IL-10), and interferon-gamma (IFN-gamma). Octreotide 0-3 interferon gamma Homo sapiens 159-168 21979989-9 2011 OCT inhibited PBMC proliferation and PBMC secretion of IL-6, IL-10 and IFN-gamma stimulated by GH. Octreotide 0-3 interferon gamma Homo sapiens 71-80 22128256-0 2011 Lactosylceramide Mediates the Expression of Adhesion Molecules in TNF-alpha and IFNgamma-stimulated Primary Cultured Astrocytes. CDw17 antigen 0-16 interferon gamma Homo sapiens 80-88 22128256-1 2011 Here we have investigated how lactosylceramide (LacCer) modulates gene expression of adhesion molecules in TNF-alpha and IFNgamma (CM)-stimulated astrocytes. CDw17 antigen 30-46 interferon gamma Homo sapiens 121-129 21943782-3 2011 Compared with the placebo plus MTX group, serum levels of IL-17, IFN-gamma, IL-21 and IL-1beta significantly decreased, the percentages of Th17 cells and Th1 cells were lower and the percentage of Treg cells was higher after receiving Anakinra combined with MTX treatment. Methotrexate 31-34 interferon gamma Homo sapiens 65-74 21726543-3 2011 Further, mitogen and antigen-stimulated cytokine (IL-2, IL-4, IL-6 and IFN-gamma) secretion by T cells was also abrogated by curcumin and DiMC. Curcumin 125-133 interferon gamma Homo sapiens 71-80 21926986-4 2011 Expression of NOS2 and production of nitric oxide paralleled the activation of T cells and required a tripartite synergism of interferon-gamma, tumor necrosis factor and direct contact with activated T cells. Nitric Oxide 37-49 interferon gamma Homo sapiens 126-142 21673342-2 2011 Using IL-2-primed cultures of CD56(+) peripheral blood mononuclear cells, we show here that zoledronic acid (zoledronate) could induce IFN-gamma production not only in gammadelta T lymphocytes but, surprisingly, also in natural killer (NK) cells in a manner that depended on antigen-presenting cells, which share properties of inflammatory monocytes and dendritic cells (DCs; here referred to as DC-like cells). Zoledronic Acid 92-107 interferon gamma Homo sapiens 135-144 21931292-16 2011 Zoledronate-expanded gammadelta T cells display CD27(-)CD45RA(-) effector memory phenotype and thier function can be evaluated by IFN-gamma production assay. Zoledronic Acid 0-11 interferon gamma Homo sapiens 130-139 21673342-2 2011 Using IL-2-primed cultures of CD56(+) peripheral blood mononuclear cells, we show here that zoledronic acid (zoledronate) could induce IFN-gamma production not only in gammadelta T lymphocytes but, surprisingly, also in natural killer (NK) cells in a manner that depended on antigen-presenting cells, which share properties of inflammatory monocytes and dendritic cells (DCs; here referred to as DC-like cells). Zoledronic Acid 109-120 interferon gamma Homo sapiens 135-144 21673342-6 2011 Pharmacologic inhibition of caspase-1 almost abolished IFN-gamma production in NK cells and gammadelta T lymphocytes, indicating that caspase-1-mediated cytokine maturation is the crucial mechanism underlying innate lymphocyte activation in response to zoledronate. Zoledronic Acid 253-264 interferon gamma Homo sapiens 55-64 21931292-16 2011 Zoledronate-expanded gammadelta T cells display CD27(-)CD45RA(-) effector memory phenotype and thier function can be evaluated by IFN-gamma production assay. thier 95-100 interferon gamma Homo sapiens 130-139 22924155-0 2011 Controlling Nuclear Jaks and Stats for Specific Gene Activation by Ifn gamma and Other Cytokines: A Possible Steroid-like Connection. Steroids 109-116 interferon gamma Homo sapiens 67-76 24900274-1 2011 Several novel C-pseudonucleosides bearing thiazolidin-4-one were synthesized by one-pot three-component condensation using unprotected sugar aldehyde at room temperature, and their effects on T cells, B cells, the cytokine secretion of IL-2, IL-4, and IFN-gamma, T cell-associated molecules (CD3, CD4, CD8), and B cell-associated molecules (CD19) were first evaluated. c-pseudonucleosides 14-33 interferon gamma Homo sapiens 252-261 21545428-7 2011 Mature GSH-OEt-treated MD-DCs enhanced interferon (IFN)-gamma production from CD4(+) T cells compared with nontreated MD-DCs, and small interfering RNA (siRNA) against IL-27 suppressed the effect of GSH-OEt on IFN-gamma production. Glutathione 7-10 interferon gamma Homo sapiens 39-61 21545428-7 2011 Mature GSH-OEt-treated MD-DCs enhanced interferon (IFN)-gamma production from CD4(+) T cells compared with nontreated MD-DCs, and small interfering RNA (siRNA) against IL-27 suppressed the effect of GSH-OEt on IFN-gamma production. Glutathione 7-10 interferon gamma Homo sapiens 210-219 21545428-7 2011 Mature GSH-OEt-treated MD-DCs enhanced interferon (IFN)-gamma production from CD4(+) T cells compared with nontreated MD-DCs, and small interfering RNA (siRNA) against IL-27 suppressed the effect of GSH-OEt on IFN-gamma production. S-ethyl glutathione 7-14 interferon gamma Homo sapiens 39-61 21545428-7 2011 Mature GSH-OEt-treated MD-DCs enhanced interferon (IFN)-gamma production from CD4(+) T cells compared with nontreated MD-DCs, and small interfering RNA (siRNA) against IL-27 suppressed the effect of GSH-OEt on IFN-gamma production. S-ethyl glutathione 7-14 interferon gamma Homo sapiens 210-219 21545428-8 2011 Additionally, although human myeloid DCs activated by TSLP (TSLP-DCs) prime naive CD4(+) T cells to differentiate into Th2 cells, treatment of TSLP-DCs with GSH-OEt reduced IL-13 production and enhanced IFN-gamma production by CD4(+) T cells. Glutathione 157-160 interferon gamma Homo sapiens 203-212 21658970-6 2011 In contrast, serum levels of IFN-gamma were significantly lower in both steroid-naive and steroid-treated groups of asthmatic children compared to healthy control subjects. Steroids 72-79 interferon gamma Homo sapiens 29-38 20935307-2 2011 The aim of our study was to evaluate the clinical usefulness of (18)F-fluorodeoxyglucose positron emission tomography/CT ((18)F-FDG-PET/CT) in patients with uveitis and positive interferon-gamma release assay. Fluorodeoxyglucose F18 70-88 interferon gamma Homo sapiens 178-194 21658970-6 2011 In contrast, serum levels of IFN-gamma were significantly lower in both steroid-naive and steroid-treated groups of asthmatic children compared to healthy control subjects. Steroids 90-97 interferon gamma Homo sapiens 29-38 21843792-3 2011 We found that PGEA suppressed the IFN-gamma/TNF-alpha-co-induced production of thymus and activation-regulated chemokine (TARC) protein and mRNA in HaCaT cells. pgea 14-18 interferon gamma Homo sapiens 34-43 22977599-8 2011 The same trend was observed for IFNgamma where in the presence of poly(I:C) an 8.7-fold increase was noted and in the presence of endogenous RNA a 3.1-fold decrease was observed. Poly I-C 66-75 interferon gamma Homo sapiens 32-40 21635197-3 2011 EXPERT OPINION: Ceramide participates in beta-cell dysfunction and apoptosis after exposure to TNFalpha, IL-1beta and IFN-gamma, excessive amyloid and islet amyloid polypeptide or non-esterified fatty acids (lipotoxicity). Ceramides 16-24 interferon gamma Homo sapiens 118-127 21664396-2 2011 Herein, the in vitro function of separated CD3(+)CD4(+)CD25(+)Foxp3(+)IFN-gamma(+) PBL that were induced by phorbol 12-myristate 13-acetate (PMA)/ionomycin or alloantigenic stimulation was investigated using cell coculture techniques and flow cytometry. Tetradecanoylphorbol Acetate 108-139 interferon gamma Homo sapiens 70-79 21664396-2 2011 Herein, the in vitro function of separated CD3(+)CD4(+)CD25(+)Foxp3(+)IFN-gamma(+) PBL that were induced by phorbol 12-myristate 13-acetate (PMA)/ionomycin or alloantigenic stimulation was investigated using cell coculture techniques and flow cytometry. Tetradecanoylphorbol Acetate 141-144 interferon gamma Homo sapiens 70-79 21664396-2 2011 Herein, the in vitro function of separated CD3(+)CD4(+)CD25(+)Foxp3(+)IFN-gamma(+) PBL that were induced by phorbol 12-myristate 13-acetate (PMA)/ionomycin or alloantigenic stimulation was investigated using cell coculture techniques and flow cytometry. Ionomycin 146-155 interferon gamma Homo sapiens 70-79 21664396-3 2011 CD4(+)CD25(+)Foxp3(+) PBL with intracellular IFN-gamma production increased to 26% in cell cultures stimulated with PMA/ionomycin for 6 hours. Tetradecanoylphorbol Acetate 116-119 interferon gamma Homo sapiens 45-54 21664396-3 2011 CD4(+)CD25(+)Foxp3(+) PBL with intracellular IFN-gamma production increased to 26% in cell cultures stimulated with PMA/ionomycin for 6 hours. Ionomycin 120-129 interferon gamma Homo sapiens 45-54 21664396-6 2011 Addition of enriched CD4(+)CD25(+)IFN-gamma(+) PBL to autologous PMA/ionomycin stimulated PBL decreased blast formation (p < 0.05), indicating suppression of cell proliferation by CD4(+)CD25(+)IFN-gamma(+) PBL. Ionomycin 69-78 interferon gamma Homo sapiens 34-43 21866053-4 2011 RESULTS: In lipopolysaccharide-stimulated PBMCs from controls, Pd salt inhibited IFN-gamma and IL-10 release, whereas Pd nanoparticles enhanced IFN-gamma release and inhibited TNF-alpha secretion. pd salt 63-70 interferon gamma Homo sapiens 81-90 21843792-4 2011 Additionally, PGEA inhibited the TNF-alpha/IFN-gamma-co-induced activation of NF-kappaB and STAT1 and increased the expression of heme oxygenase-1 (HO-1) protein and mRNA. pgea 14-18 interferon gamma Homo sapiens 43-52 21843792-5 2011 HO-1 inhibitor enhanced the suppressive effects of PGEA on TNF-alpha/IFN-gamma-co-induced TARC production and gene expression. pgea 51-55 interferon gamma Homo sapiens 69-78 21724697-6 2011 IFN-gamma levels were significantly higher in MC+HCV than in controls [6.1 (range 0.8-114.5), 1.4 (range 0.7-2.4) pg/ml, respectively; p < 0.05; Mann-Whitney U test]. Methylcholanthrene 46-49 interferon gamma Homo sapiens 0-9 21724697-10 2011 A strong relationship between circulating IFN-gamma and CXCL11 was shown, strongly supporting the role of a T helper 1 immune response in the pathogenesis of MC+HCV. Methylcholanthrene 158-161 interferon gamma Homo sapiens 42-51 21762414-5 2011 KEY RESULTS: We showed that, when challenged with a combination of LPS and IFN-gamma, EGCs are significantly activated, as indicated by their positivity to c-fos and MHC class II. egcs 86-90 interferon gamma Homo sapiens 75-84 21866053-4 2011 RESULTS: In lipopolysaccharide-stimulated PBMCs from controls, Pd salt inhibited IFN-gamma and IL-10 release, whereas Pd nanoparticles enhanced IFN-gamma release and inhibited TNF-alpha secretion. Palladium 63-65 interferon gamma Homo sapiens 81-90 21866053-5 2011 In lipopolysaccharide-stimulated PBMCs from Pd-sensitized women showing high IFN-gamma release, Pd nanoparticles inhibited TNF-alpha release and Pd salt IL-10 release. Palladium 44-46 interferon gamma Homo sapiens 77-86 24371553-8 2011 IFN-gamma significantly downregulated CD14 expression in both CPs" PMs and control. cps" pms 62-70 interferon gamma Homo sapiens 0-9 21909452-6 2011 Treatment with rIL-2/DTx suppressed lesional regulatory T cell numbers and was associated with significantly increased antigen-specific IFN-gamma production, enhanced lesion resolution and decreased parasite burden. Digitoxigenin 21-24 interferon gamma Homo sapiens 136-145 21549757-9 2011 Moreover, application of inhibitors of IDO, adenosine, neutralizing Abs to IL-10 and TGF-beta could partially reverse IFN-gamma production. idose 39-42 interferon gamma Homo sapiens 118-127 21549757-9 2011 Moreover, application of inhibitors of IDO, adenosine, neutralizing Abs to IL-10 and TGF-beta could partially reverse IFN-gamma production. Adenosine 44-53 interferon gamma Homo sapiens 118-127 21820330-5 2011 Repression of IFN-gamma production by miR-29 involved direct targeting of both T-bet and Eomes, two transcription factors known to induce IFN-gamma production. mir-29 38-44 interferon gamma Homo sapiens 14-23 21875436-5 2011 Monocyte cultures activated in vitro with TNF-alpha and IFN-gamma were evaluated by fungicidal activity against C. albicans by culture plating and Colony Forming Unit (CFU) recovery, and by H2O2 production. Hydrogen Peroxide 190-194 interferon gamma Homo sapiens 56-65 21820330-5 2011 Repression of IFN-gamma production by miR-29 involved direct targeting of both T-bet and Eomes, two transcription factors known to induce IFN-gamma production. mir-29 38-44 interferon gamma Homo sapiens 138-147 21477169-6 2011 MAIN OUTCOME MEASURES: Genotype distribution and allele frequency of the dinucleotide (CA)(n) repeat polymorphism in the IFN-gamma gene. Dinucleoside Phosphates 73-85 interferon gamma Homo sapiens 121-130 21646352-3 2011 Our prior study showed that human apolipoprotein L6 (ApoL6), a pro-apoptotic BH3-only member of the Bcl-2 family, was one of the downstream targets of interferon-gamma (INFgamma), which sensitizes atherosclerotic lesion-derived cells (LDCs) to Fas-induced apoptosis. ammonium ferrous sulfate 244-247 interferon gamma Homo sapiens 151-167 21884514-6 2011 Conversely, IL-23 plus IL-1beta partially opposed the PGE2-mediated repression of early interferon gamma (IFN-gamma) secretion from CD161(+) cells, as well as the PGE2-mediated depletion of IFN-gamma(+) CD161(+) cells. Dinoprostone 54-58 interferon gamma Homo sapiens 88-115 21490083-5 2011 In addition, the direct effect of rosiglitazone was evaluated in peritoneal macrophages activated with interferon-gamma. Rosiglitazone 34-47 interferon gamma Homo sapiens 103-119 21490083-8 2011 In peritoneal macrophages, rosiglitazone down-regulated interferon-gamma-induced gene expression of cyclooxygenase-2 and inducible nitric oxide synthase and attenuated the chemotactic response to monocyte chemotactic protein-1. Rosiglitazone 27-40 interferon gamma Homo sapiens 56-72 21511030-2 2011 Following IFN-gamma stimulation, STAT1 is activated through tyrosine phosphorylation. Tyrosine 60-68 interferon gamma Homo sapiens 10-19 21884514-6 2011 Conversely, IL-23 plus IL-1beta partially opposed the PGE2-mediated repression of early interferon gamma (IFN-gamma) secretion from CD161(+) cells, as well as the PGE2-mediated depletion of IFN-gamma(+) CD161(+) cells. Dinoprostone 54-58 interferon gamma Homo sapiens 106-115 21884514-7 2011 Our results suggest that PGE2 and IL-23 plus IL-1beta induce the Th17 immune response preferentially in CD161(+) CD4(+) memory T cells, while divergently regulating their ability to express IFN-gamma. Dinoprostone 25-29 interferon gamma Homo sapiens 190-199 21683432-3 2011 METHODS: Mitogen (concanavalin A/phorbol 12-myristate 13-acetate)-stimulated IL-4, IL-5, IL-13, and IFN-gamma levels were measured in supernatants from cord blood mononuclear cells and PBMCs at birth, 3 months, and 12 months. Tetradecanoylphorbol Acetate 33-64 interferon gamma Homo sapiens 100-109 21593768-7 2011 GW9508 further suppressed expression of IL-11, IL-24, and IL-33 induced in HaCaT cells by TNF-alpha and IFN-gamma. GW9508 0-6 interferon gamma Homo sapiens 104-113 21672594-5 2011 We therefore tested whether GEN would prevent apoptosis in cultured motoneurons following exposure to pro-inflammatory cytokines released from IFN-gamma activated microglia. Genistein 28-31 interferon gamma Homo sapiens 143-152 21804080-5 2011 Interferon-gamma and interleukin-1alpha, but not interferon-alpha, treatment of cultured dermal fibroblasts induced mRNA expression of CHST-11, which attaches sulfates to the 4-position of unsulfated chondroitin. Sulfates 159-167 interferon gamma Homo sapiens 0-16 21804080-5 2011 Interferon-gamma and interleukin-1alpha, but not interferon-alpha, treatment of cultured dermal fibroblasts induced mRNA expression of CHST-11, which attaches sulfates to the 4-position of unsulfated chondroitin. Chondroitin 200-211 interferon gamma Homo sapiens 0-16 21787231-3 2011 We showed that, when combined to CpG ODN, poly-arginine and poly-histidine, but not poly-lysine or chitosan, enhanced efficiently both the IgG antibody production and the number of splenocytes secreting interferon-gamma after stimulation with a CD8+ T cell-restricted peptide. polyarginine 42-55 interferon gamma Homo sapiens 203-219 21787231-3 2011 We showed that, when combined to CpG ODN, poly-arginine and poly-histidine, but not poly-lysine or chitosan, enhanced efficiently both the IgG antibody production and the number of splenocytes secreting interferon-gamma after stimulation with a CD8+ T cell-restricted peptide. polyhistidine 60-74 interferon gamma Homo sapiens 203-219 21500970-13 2011 However, RANTES expression detected in supernatant stimulated with TNF-alpha/IFN-gamma reduced 15 and 16%, respectively, when cultured with 0.25, 0.5 mmol/L naringin. naringin 157-165 interferon gamma Homo sapiens 77-86 21586573-3 2011 Only the p38 MAPK inhibitor, SB203580, abrogated ESAT-6-mediated inhibition of IFN-gamma production in a dose-dependent manner. SB 203580 29-37 interferon gamma Homo sapiens 79-88 21646474-2 2011 Doxorubicin treatment enhances tumor antigen-specific proliferation of CD8 T cells in tumor-draining lymph nodes and promotes tumor infiltration of activated, IFN-gamma-producing CD8 T cells. Doxorubicin 0-11 interferon gamma Homo sapiens 159-168 21646474-6 2011 In tumor samples taken from breast cancer patients prior to treatment with anthracycline chemotherapy, a correlation between CD8alpha, CD8beta, and IFN-gamma gene expression levels and clinical response was observed, supporting their role in the therapeutic efficacy of anthracyclines in humans. Anthracyclines 75-88 interferon gamma Homo sapiens 148-157 21646474-6 2011 In tumor samples taken from breast cancer patients prior to treatment with anthracycline chemotherapy, a correlation between CD8alpha, CD8beta, and IFN-gamma gene expression levels and clinical response was observed, supporting their role in the therapeutic efficacy of anthracyclines in humans. Anthracyclines 270-284 interferon gamma Homo sapiens 148-157 21586573-3 2011 Only the p38 MAPK inhibitor, SB203580, abrogated ESAT-6-mediated inhibition of IFN-gamma production in a dose-dependent manner. esat-6 49-55 interferon gamma Homo sapiens 79-88 21586573-4 2011 SB203580 did not reverse ESAT-6-mediated inhibition of IL-17 and IL-10 production, suggesting a specific effect of SB203580 on IFN-gamma production. SB 203580 115-123 interferon gamma Homo sapiens 127-136 21586573-8 2011 Incubation of peripheral blood mononuclear cells with ESAT-6 induced activation of p38 MAPK, and inhibition of p38 MAPK with SB203580 reversed ESAT-6 inhibition of M. tuberculosis-stimulated IFN-gamma production by peripheral blood mononuclear cells from subjects with latent tuberculosis infection. SB 203580 125-133 interferon gamma Homo sapiens 191-200 20854895-9 2011 Similar to the in vitro results, the beneficial effect of DHA in EAE was associated with reduced numbers of IFNgamma- and IL-17-producing CD4(+) T cells in both spleen and CNS. Docosahexaenoic Acids 58-61 interferon gamma Homo sapiens 108-127 21047568-8 2011 Zoledronic acid administration triggered increased serum levels of TNFalpha, IFNgamma, IL-6 and CRP in >=70% of study volunteers, whilst characteristic APR symptoms were observed in >50% of participants. Zoledronic Acid 0-15 interferon gamma Homo sapiens 77-85 21606674-6 2011 Activation of ERK1/2 was crucial for IFNgamma-induced cell death because MEK1/2 inhibitors, PD0325901 and U0126 efficiently protected cells from apoptosis by suppressing caspase-3 activation. mirdametinib 92-101 interferon gamma Homo sapiens 37-45 21606674-6 2011 Activation of ERK1/2 was crucial for IFNgamma-induced cell death because MEK1/2 inhibitors, PD0325901 and U0126 efficiently protected cells from apoptosis by suppressing caspase-3 activation. U 0126 106-111 interferon gamma Homo sapiens 37-45 21606674-7 2011 Even though EGFR tyrosine kinase inhibitor AG1478 also rescued A431 cells from IFNgamma-induced apoptosis, unlike MEK1/2 inhibitors, it initiated G 1 arrest. RTKI cpd 43-49 interferon gamma Homo sapiens 79-87 21712444-10 2011 Functional T-cell reactivity was observed in all groups, except for patients treated with sorafenib who showed a decreased proliferation rate and IFN-gamma/IL-2 production and increased IL-10 compared with healthy controls. Sorafenib 90-99 interferon gamma Homo sapiens 146-155 21440296-7 2011 Moreover, the mPEI-based nanocomplexes significantly enhanced the number of interferon-gamma producing CD8(+) T cells compared with the use of mixed proteins and plasmid DNA. mpei 14-18 interferon gamma Homo sapiens 76-92 21568934-4 2011 The elimination of MDSC by 5-FU increased IFNgamma secretion by tumor specific CD8(+) T cells infiltrating the tumor and promoted T-cell dependent antitumor responses in vivo, suggesting that some anticancer therapies can reverse tumor-mediated immunosuppression. Fluorouracil 27-31 interferon gamma Homo sapiens 42-50 21746772-7 2011 Interferon gamma (IFN-gamma) expression in monocytes correlated negatively with brachial artery flow-mediated dilatation also in the Leu7Pro7 group (p=0.037). leu7pro7 133-141 interferon gamma Homo sapiens 0-16 21746772-7 2011 Interferon gamma (IFN-gamma) expression in monocytes correlated negatively with brachial artery flow-mediated dilatation also in the Leu7Pro7 group (p=0.037). leu7pro7 133-141 interferon gamma Homo sapiens 18-27 21600206-10 2011 In LPMCs from patients with IBD, incubation with Ficz reduced levels of interferon gamma (IFN)-gamma and up-regulated IL-22. lpmcs 3-8 interferon gamma Homo sapiens 72-100 21508145-8 2011 Levothyroxine reduced monocyte release of TNF-alpha, IL-1beta, IL-6, and monocyte chemoattractant protein-1, whereas selenomethionine inhibited lymphocyte release of IL-2, interferon-gamma, and TNF-alpha, which was accompanied by a reduction in plasma CRP levels. Selenomethionine 117-133 interferon gamma Homo sapiens 172-188 21540068-7 2011 MbetaCD and IL-2 synergistically could also induce interferon-gamma (IFN-gamma) production in CD56(+) human PBMCs. methyl-beta-cyclodextrin 0-7 interferon gamma Homo sapiens 51-67 21540068-7 2011 MbetaCD and IL-2 synergistically could also induce interferon-gamma (IFN-gamma) production in CD56(+) human PBMCs. methyl-beta-cyclodextrin 0-7 interferon gamma Homo sapiens 69-78 21540068-8 2011 Mechanistic studies revealed that IFN-gamma production in response to MbetaCD plus IL-2 was IL-12 independent but depended on endogenous IL-18 and IL-1beta, and CD56(+)CD14(+) dendritic cell-like cells and B cells might mediate the ability of MbetaCD to activate NK cells. methyl-beta-cyclodextrin 70-77 interferon gamma Homo sapiens 34-43 21540068-8 2011 Mechanistic studies revealed that IFN-gamma production in response to MbetaCD plus IL-2 was IL-12 independent but depended on endogenous IL-18 and IL-1beta, and CD56(+)CD14(+) dendritic cell-like cells and B cells might mediate the ability of MbetaCD to activate NK cells. methyl-beta-cyclodextrin 243-250 interferon gamma Homo sapiens 34-43 21238620-6 2011 Urethane led to lung nodules development after 120 days and the time point evaluation showed that splenocytes stimulated ex vivo expressed higher levels of IFN-gamma 20 days after the chemical injection. Urethane 0-8 interferon gamma Homo sapiens 156-165 21315783-3 2011 Sunitinib also targets myeloid derived suppressor cells (MDSCs) significantly reducing their accumulation in the peripheral blood and reversing T cell (IFNgamma) suppression in both mRCC patients and in murine tumor models. Sunitinib 0-9 interferon gamma Homo sapiens 152-160 21576359-5 2011 IFN-gamma induced progressive accumulation of reactive oxygen species (ROS) and eventual loss of mitochondrial membrane potential in cells lacking the NF-kappaB subunit RelA. Reactive Oxygen Species 46-69 interferon gamma Homo sapiens 0-9 21632719-6 2011 Prevention of the increase in Fas expression using Fas small interfering RNAs blocked the ability of TNF-alpha and IFN-gamma to sensitize fibroblasts to Fas ligation-induced apoptosis, whereas enforced adenovirus-mediated Fas overexpression was sufficient to overcome basal resistance to Fas-induced apoptosis. ammonium ferrous sulfate 30-33 interferon gamma Homo sapiens 115-124 21576359-5 2011 IFN-gamma induced progressive accumulation of reactive oxygen species (ROS) and eventual loss of mitochondrial membrane potential in cells lacking the NF-kappaB subunit RelA. Reactive Oxygen Species 71-74 interferon gamma Homo sapiens 0-9 21576359-7 2011 Overexpression of MnSOD inhibited IFN-gamma-mediated ROS accumulation and partially rescued RelA-deficient cells from necroptosis, while RNA interference (RNAi)-mediated silencing of sod2 expression increased susceptibility to IFN-gamma-induced cell death. Reactive Oxygen Species 53-56 interferon gamma Homo sapiens 34-43 21576359-8 2011 Together, these studies demonstrate that NF-kappaB protects cells from IFN-gamma-mediated necroptosis by transcriptionally activating a survival response that quenches ROS to preserve mitochondrial integrity. Reactive Oxygen Species 168-171 interferon gamma Homo sapiens 71-80 21497059-4 2011 We previously demonstrated that atypical antipsychotics including aripiprazole significantly inhibited the release of nitric oxide and proinflammatory cytokines from interferon-gamma-stimulated microglia in vitro. Aripiprazole 66-78 interferon gamma Homo sapiens 166-182 21497059-4 2011 We previously demonstrated that atypical antipsychotics including aripiprazole significantly inhibited the release of nitric oxide and proinflammatory cytokines from interferon-gamma-stimulated microglia in vitro. Nitric Oxide 118-130 interferon gamma Homo sapiens 166-182 21722526-8 2011 ELISA detection manifested that compared with the untreated group different concentrations of RPM could significantly inhibit the IL-2 and IFN-gamma secretion and significantly inhibited T lymphocyte proliferation (P<0.01). Sirolimus 94-97 interferon gamma Homo sapiens 139-148 20960460-5 2011 We here comparatively analyzed the effect of the two clinically available azanucleosides and report that NK cytotoxicity and IFN-gamma production are significantly impaired by pharmacological concentrations of azacytidine but enhanced by decitabine. azanucleosides 74-88 interferon gamma Homo sapiens 125-134 21283989-2 2011 Very few compounds have been found to stimulate iNKT cells, and of these, the best characterised is the glycolipid alpha-galactosylceramide, which stimulates the production of large quantities of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4). Glycolipids 104-114 interferon gamma Homo sapiens 196-212 21283989-2 2011 Very few compounds have been found to stimulate iNKT cells, and of these, the best characterised is the glycolipid alpha-galactosylceramide, which stimulates the production of large quantities of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4). Glycolipids 104-114 interferon gamma Homo sapiens 214-223 21283989-2 2011 Very few compounds have been found to stimulate iNKT cells, and of these, the best characterised is the glycolipid alpha-galactosylceramide, which stimulates the production of large quantities of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4). alpha-galactosylceramide 115-139 interferon gamma Homo sapiens 196-212 21283989-2 2011 Very few compounds have been found to stimulate iNKT cells, and of these, the best characterised is the glycolipid alpha-galactosylceramide, which stimulates the production of large quantities of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4). alpha-galactosylceramide 115-139 interferon gamma Homo sapiens 214-223 21283989-8 2011 In terms of cellular responses, IFN-gamma secretion was higher for cells treated with small DDA liposomes compared with the other liposome formulations, suggesting that ThrCer encapsulation in this liposome formulation resulted in a higher uptake by DCs. dimethyldioctadecylammonium 92-95 interferon gamma Homo sapiens 32-41 21283989-8 2011 In terms of cellular responses, IFN-gamma secretion was higher for cells treated with small DDA liposomes compared with the other liposome formulations, suggesting that ThrCer encapsulation in this liposome formulation resulted in a higher uptake by DCs. thrcer 169-175 interferon gamma Homo sapiens 32-41 20960460-5 2011 We here comparatively analyzed the effect of the two clinically available azanucleosides and report that NK cytotoxicity and IFN-gamma production are significantly impaired by pharmacological concentrations of azacytidine but enhanced by decitabine. Azacitidine 210-221 interferon gamma Homo sapiens 125-134 20960460-5 2011 We here comparatively analyzed the effect of the two clinically available azanucleosides and report that NK cytotoxicity and IFN-gamma production are significantly impaired by pharmacological concentrations of azacytidine but enhanced by decitabine. Decitabine 238-248 interferon gamma Homo sapiens 125-134 22308202-0 2011 Neopterin, a Marker of Interferon-Gamma-Inducible Inflammation, Correlates with Pyridoxal-5"-Phosphate, Waist Circumference, HDL-Cholesterol, Insulin Resistance and Mortality Risk in Adult Boston Community Dwellers of Puerto Rican Origin. Neopterin 0-9 interferon gamma Homo sapiens 23-39 21505297-10 2011 CONCLUSION: Patients with unmasking TB-IRIS had higher pre-ART levels of plasma IFN-gamma and CRP, consistent with preexisting subclinical TB. Terbium 36-38 interferon gamma Homo sapiens 80-89 22308202-0 2011 Neopterin, a Marker of Interferon-Gamma-Inducible Inflammation, Correlates with Pyridoxal-5"-Phosphate, Waist Circumference, HDL-Cholesterol, Insulin Resistance and Mortality Risk in Adult Boston Community Dwellers of Puerto Rican Origin. Cholesterol 129-140 interferon gamma Homo sapiens 23-39 22308202-1 2011 Interferon-gamma (IFNG), a pro-inflammatory cytokine, increases concentrations of neopterin, a stable pteridine derivative, due to IFNG-induced transcriptional activation of the rate-limiting enzyme of pteridines biosynthesis. Neopterin 82-91 interferon gamma Homo sapiens 0-16 22308202-1 2011 Interferon-gamma (IFNG), a pro-inflammatory cytokine, increases concentrations of neopterin, a stable pteridine derivative, due to IFNG-induced transcriptional activation of the rate-limiting enzyme of pteridines biosynthesis. Neopterin 82-91 interferon gamma Homo sapiens 18-22 22308202-1 2011 Interferon-gamma (IFNG), a pro-inflammatory cytokine, increases concentrations of neopterin, a stable pteridine derivative, due to IFNG-induced transcriptional activation of the rate-limiting enzyme of pteridines biosynthesis. Neopterin 82-91 interferon gamma Homo sapiens 131-135 22308202-1 2011 Interferon-gamma (IFNG), a pro-inflammatory cytokine, increases concentrations of neopterin, a stable pteridine derivative, due to IFNG-induced transcriptional activation of the rate-limiting enzyme of pteridines biosynthesis. Pteridines 102-111 interferon gamma Homo sapiens 0-16 22308202-1 2011 Interferon-gamma (IFNG), a pro-inflammatory cytokine, increases concentrations of neopterin, a stable pteridine derivative, due to IFNG-induced transcriptional activation of the rate-limiting enzyme of pteridines biosynthesis. Pteridines 102-111 interferon gamma Homo sapiens 18-22 22308202-1 2011 Interferon-gamma (IFNG), a pro-inflammatory cytokine, increases concentrations of neopterin, a stable pteridine derivative, due to IFNG-induced transcriptional activation of the rate-limiting enzyme of pteridines biosynthesis. Pteridines 102-111 interferon gamma Homo sapiens 131-135 22308202-1 2011 Interferon-gamma (IFNG), a pro-inflammatory cytokine, increases concentrations of neopterin, a stable pteridine derivative, due to IFNG-induced transcriptional activation of the rate-limiting enzyme of pteridines biosynthesis. Pteridines 202-212 interferon gamma Homo sapiens 0-16 22308202-1 2011 Interferon-gamma (IFNG), a pro-inflammatory cytokine, increases concentrations of neopterin, a stable pteridine derivative, due to IFNG-induced transcriptional activation of the rate-limiting enzyme of pteridines biosynthesis. Pteridines 202-212 interferon gamma Homo sapiens 18-22 22308202-1 2011 Interferon-gamma (IFNG), a pro-inflammatory cytokine, increases concentrations of neopterin, a stable pteridine derivative, due to IFNG-induced transcriptional activation of the rate-limiting enzyme of pteridines biosynthesis. Pteridines 202-212 interferon gamma Homo sapiens 131-135 22308202-9 2011 PLP is a cofactor of IFNG-induced key enzymes of tryptophan-kynurenine metabolism. Tryptophan 49-59 interferon gamma Homo sapiens 21-25 22308202-9 2011 PLP is a cofactor of IFNG-induced key enzymes of tryptophan-kynurenine metabolism. Kynurenine 60-70 interferon gamma Homo sapiens 21-25 22308202-11 2011 Assessment of neopterin concentrations might help to monitor the activity of IFNG-inducible inflammation associated with aging-associated medical and psychiatric disorders. Neopterin 14-23 interferon gamma Homo sapiens 77-81 21386060-3 2011 IFN-beta suppressed insulin-induced tyrosine phosphorylation of IRS-1 without affecting its expression, whereas IFN-gamma reduced both the protein level and tyrosine phosphorylation. Tyrosine 157-165 interferon gamma Homo sapiens 112-121 21386060-1 2011 Although elevation of the blood glucose level is a causal adverse effect of treatment with interferon (IFN), the precise underlying molecular mechanism is largely unknown. Glucose 32-39 interferon gamma Homo sapiens 103-106 21386060-8 2011 In contrast, adenovirus-mediated expression of a dominant-negative STAT3 (F-STAT3) attenuated IFN-gamma-induced SOCS3 expression, reduction of IRS-1 protein, and suppression of insulin-induced glucose uptake but did not have any effect on the IFN-beta-mediated SOCS1 expression and inhibition of insulin-induced glucose uptake. Glucose 193-200 interferon gamma Homo sapiens 94-103 21386060-2 2011 We examined the effects of type I and type II IFN (IFN-beta and IFN-gamma) on insulin-induced metabolic signaling leading to glucose uptake in 3T3-L1 adipocytes. Glucose 125-132 interferon gamma Homo sapiens 64-73 21386060-8 2011 In contrast, adenovirus-mediated expression of a dominant-negative STAT3 (F-STAT3) attenuated IFN-gamma-induced SOCS3 expression, reduction of IRS-1 protein, and suppression of insulin-induced glucose uptake but did not have any effect on the IFN-beta-mediated SOCS1 expression and inhibition of insulin-induced glucose uptake. Glucose 312-319 interferon gamma Homo sapiens 94-103 21545812-3 2011 HBsAg+JVRS-100 elicited a T cell response and B cell response as evidenced by interferon-gamma (IFN-gamma) secretion by re-stimulated splenocytes and anti-HBsAg IgG induction, respectively, whereas, HBsAg only elicited a B cell response. jvrs-100 6-14 interferon gamma Homo sapiens 78-94 21545812-3 2011 HBsAg+JVRS-100 elicited a T cell response and B cell response as evidenced by interferon-gamma (IFN-gamma) secretion by re-stimulated splenocytes and anti-HBsAg IgG induction, respectively, whereas, HBsAg only elicited a B cell response. jvrs-100 6-14 interferon gamma Homo sapiens 96-105 21692201-11 2011 Both rIL-23 and rIL-12 could increase IFN-gamma production by CD4+ T cells from BD patients and normal controls. ril-23 5-11 interferon gamma Homo sapiens 38-47 22779186-7 2011 IFN-gamma expression and production were also inhibited by triptolide. triptolide 59-69 interferon gamma Homo sapiens 0-9 21534013-2 2011 It was found that the expression of Fas in PBL and the level of IL-4 in the serum of hemodialysis patients were significantly higher (P < 0.01), whereas Bcl-2 in PBL and IFN-gamma in the serum were significantly lower (P < 0.01) than those of the normal controls. ammonium ferrous sulfate 36-39 interferon gamma Homo sapiens 173-182 21690049-6 2011 The effects of IFN-gamma, IL-4, and TGF-beta on asthma may also be attributed to their actions on HASMCs. hasmcs 98-104 interferon gamma Homo sapiens 15-24 21549779-8 2011 Taken together, these results suggest a novel way for local kinin and des-Arg-kinin generation in the nervous tissue during pathological states accompanied by interferon-gamma release. Diethylstilbestrol 70-73 interferon gamma Homo sapiens 159-175 21549779-8 2011 Taken together, these results suggest a novel way for local kinin and des-Arg-kinin generation in the nervous tissue during pathological states accompanied by interferon-gamma release. Arginine 74-77 interferon gamma Homo sapiens 159-175 21668360-7 2011 For responses restricted by other MHC class I alleles, dual IFN-gamma/IL-2-secreting lymphocytes contributed significantly more to the total response in SP than progressors. sp 153-155 interferon gamma Homo sapiens 60-69 21781515-4 2011 The percentage of CD(69)(+) EOS stimulated by interleukin-5 (IL-5) and interferon gamma (IFN-gamma) was also detected by FACS. Cadmium 18-20 interferon gamma Homo sapiens 71-98 21781515-8 2011 After stimulated by IL-5 and IFN-gamma, the percentage of CD(69)(+) EOS in induced sputum was 1.5 +- 0.4 and 1.5 +- 0.5 (EB group), 1.4 +- 0.4 and 1.4 +- 0.3 (CVA group) and 1.42 +- 0.72 and 1.37 +- 0.46 (asthma group) respectively. Cadmium 58-60 interferon gamma Homo sapiens 29-38 21781515-8 2011 After stimulated by IL-5 and IFN-gamma, the percentage of CD(69)(+) EOS in induced sputum was 1.5 +- 0.4 and 1.5 +- 0.5 (EB group), 1.4 +- 0.4 and 1.4 +- 0.3 (CVA group) and 1.42 +- 0.72 and 1.37 +- 0.46 (asthma group) respectively. Eriochrome Blue SE 121-123 interferon gamma Homo sapiens 29-38 21624163-4 2011 It is hypothesized that the application of VO will enhance the prediction of IFN-gamma and vaccine-mediated gene interaction network. Vanadium(II) oxide 43-45 interferon gamma Homo sapiens 77-86 21402701-6 2011 Inhibition of class III histone deacetylases increased the production of IL-12 p70 and partially blunted the inhibitory effect of zymosan on the production of IL-12 p70 elicited by LPS and IFN-gamma. Zymosan 130-137 interferon gamma Homo sapiens 189-198 21357681-8 2011 The growth inhibition of mesothelioma cells was mediated by IFN-gamma that was only detected in the supernatant when effector cells were exposed to 5-aza-dC-treated tumors in the presence of anti-IL-13Ralpha2. Decitabine 148-156 interferon gamma Homo sapiens 60-69 21573215-16 2011 CONCLUSIONS/SIGNIFICANCE: This study demonstrates the feasibility of mc-oriP-IFNgamma as a safe and highly effective targeted gene therapeutic system for the treatment of EBV positive NPC. Methylcholanthrene 69-71 interferon gamma Homo sapiens 77-85 21324712-5 2011 Histamine suppressed tumor necrosis factor alpha (TNF-alpha)- and interferon-gamma (IFN-gamma)-induced production of CC chemokine ligand 17(CCL17), a type 2 T-helper (Th2) chemokine, by HaCaT KCs. Histamine 0-9 interferon gamma Homo sapiens 66-93 21324712-7 2011 In contrast, histamine enhanced the production of CXC chemokine ligand 10 (CXCL10), a Th1 chemokine, by TNF-alpha- and IFN-gamma-stimulated HaCaT KCs and NHKs. Histamine 13-22 interferon gamma Homo sapiens 119-128 21324712-8 2011 TNF-alpha- and IFN-gamma-induced CXCL10 production was upregulated by suppression of p38 MAP kinase or NF-kappaB activity, which could explain histamine involvement. Histamine 143-152 interferon gamma Homo sapiens 15-24 21297491-5 2011 RESULTS: In comparison with the control group, the proportions of CD4+CD25+ Tregs and the mRNA level of FoxP3 and transforming growth factor-beta significantly increased; however, interferon-gamma decreased with atorvastatin therapy. Atorvastatin 212-224 interferon gamma Homo sapiens 180-196 21239188-11 2011 CONCLUSION: A genetic predisposition to elevated IFN-gamma levels may play a dual role in controlling active CMV infection among lung transplant recipients receiving alemtuzumab induction and valganciclovir prophylaxis, limiting the extent of viral replication in serum but increasing the risk of CMV disease. Valganciclovir 192-206 interferon gamma Homo sapiens 49-58 21330350-5 2011 Zoledronate induced clear proliferation and IFN-gamma production in neonatal Vgamma9Vdelta2 T cells. Zoledronic Acid 0-11 interferon gamma Homo sapiens 44-53 21330350-7 2011 Addition of IL-23 to zoledronate enhanced the expression of IFN-gamma and generated a distinct, IFN-gamma-negative, neonatal Vgamma9Vdelta2 T cell population producing IL-17. Zoledronic Acid 21-32 interferon gamma Homo sapiens 60-69 21330350-7 2011 Addition of IL-23 to zoledronate enhanced the expression of IFN-gamma and generated a distinct, IFN-gamma-negative, neonatal Vgamma9Vdelta2 T cell population producing IL-17. Zoledronic Acid 21-32 interferon gamma Homo sapiens 96-105 21374619-6 2011 Conversely, for neutral liposomes containing TDB, although the initial amount of IFN-gamma was slightly lower than the cationic equivalent, the overall protective immune responses of these neutral liposomes were effectively maintained over time, generating good levels of protection. trehalose 6,6'-dibehenate 45-48 interferon gamma Homo sapiens 81-90 21193899-7 2011 In peritoneal macrophages and splenocytes, ITF2357 inhibited the production of nitrite, as well as that of TNFalpha and IFNgamma at an IC(50) of 25-50 nmol/L. givinostat hydrochloride 43-50 interferon gamma Homo sapiens 120-128 21360757-5 2011 Both lansoprazole (LPZ) and omeprazole (OPZ) significantly attenuated IFN-gamma-induced neurotoxicity of human astrocytes and astrocytoma cells. Lansoprazole 5-17 interferon gamma Homo sapiens 70-79 21360757-5 2011 Both lansoprazole (LPZ) and omeprazole (OPZ) significantly attenuated IFN-gamma-induced neurotoxicity of human astrocytes and astrocytoma cells. Lansoprazole 19-22 interferon gamma Homo sapiens 70-79 22074586-6 2011 T-helper cells play an important role for protection against malignancy and melatonin has been shown to enhance T-helper cell response by releasing interleukin-2, interleukin-10 and interferon-gamma. Melatonin 76-85 interferon gamma Homo sapiens 182-198 21360757-5 2011 Both lansoprazole (LPZ) and omeprazole (OPZ) significantly attenuated IFN-gamma-induced neurotoxicity of human astrocytes and astrocytoma cells. Omeprazole 28-38 interferon gamma Homo sapiens 70-79 21360757-5 2011 Both lansoprazole (LPZ) and omeprazole (OPZ) significantly attenuated IFN-gamma-induced neurotoxicity of human astrocytes and astrocytoma cells. Omeprazole 40-43 interferon gamma Homo sapiens 70-79 21360757-7 2011 We found that LPZ significantly reduced secretion of IFN-gamma-inducible T cell alpha chemoattractant from IFN-gamma-activated astrocytes. Lansoprazole 14-17 interferon gamma Homo sapiens 53-62 21360757-7 2011 We found that LPZ significantly reduced secretion of IFN-gamma-inducible T cell alpha chemoattractant from IFN-gamma-activated astrocytes. Lansoprazole 14-17 interferon gamma Homo sapiens 107-116 21499635-5 2011 The liposomes with a relatively high charge density, such as DOTAP/DOPC 5:0 and 4:1 liposomes, potently enhanced dendritic cell maturation, ROS generaion, antigen uptake, as well as the production of OVA-specific IgG2a and IFN-gamma. 1,2-dioleoyloxy-3-(trimethylammonium)propane 61-66 interferon gamma Homo sapiens 223-232 21499635-5 2011 The liposomes with a relatively high charge density, such as DOTAP/DOPC 5:0 and 4:1 liposomes, potently enhanced dendritic cell maturation, ROS generaion, antigen uptake, as well as the production of OVA-specific IgG2a and IFN-gamma. 1,2-oleoylphosphatidylcholine 67-71 interferon gamma Homo sapiens 223-232 21505270-9 2011 In ACHBLF patients, the level of IFN-gamma was positively correlated with total bilirubin and MELD score, but negatively correlated with prothrombin time activity. Bilirubin 80-89 interferon gamma Homo sapiens 33-42 21459676-10 2011 IFN-gamma but not IP-10 responses to mitogen stimulation were reduced in patients with TB and non-TB infection. Terbium 87-89 interferon gamma Homo sapiens 0-9 21459676-10 2011 IFN-gamma but not IP-10 responses to mitogen stimulation were reduced in patients with TB and non-TB infection. Terbium 98-100 interferon gamma Homo sapiens 0-9 21414301-8 2011 Furthermore, Nrf2 siRNA significantly reversed the inhibitory effect of celastrol on IFN-gamma-induced expression of ICAM-1 in the keratinocytes. celastrol 72-81 interferon gamma Homo sapiens 85-94 21533209-6 2011 The greatest TNFalpha responses were observed for TLR4, -5, and -8 agonists, the highest being the thiazoloquinoline CLO75 (TLR7/8) that also uniquely induced cord blood IFNgamma production. thiazoloquinoline 99-116 interferon gamma Homo sapiens 170-178 21441032-2 2011 Mannich bases of heterocyclic chalcones inhibited nitric oxide (NO) production in lipopolysaccharide and interferon-gamma stimulated RAW 264.7 macrophages. mannich 0-7 interferon gamma Homo sapiens 105-121 21441032-2 2011 Mannich bases of heterocyclic chalcones inhibited nitric oxide (NO) production in lipopolysaccharide and interferon-gamma stimulated RAW 264.7 macrophages. heterocyclic 17-29 interferon gamma Homo sapiens 105-121 21441032-2 2011 Mannich bases of heterocyclic chalcones inhibited nitric oxide (NO) production in lipopolysaccharide and interferon-gamma stimulated RAW 264.7 macrophages. Chalcones 30-39 interferon gamma Homo sapiens 105-121 21533209-6 2011 The greatest TNFalpha responses were observed for TLR4, -5, and -8 agonists, the highest being the thiazoloquinoline CLO75 (TLR7/8) that also uniquely induced cord blood IFNgamma production. clo75 117-122 interferon gamma Homo sapiens 170-178 21533229-5 2011 The overall profiles of cytokine responses to Gag and Ad5 had similar combinations of induced Th1- and Th2-type cytokines, including IFN-gamma, IL-2, TNF-alpha, IP-10, IL-13, and IL-10, although the Ad5-specific responses were uniformly higher than the Gag-specific responses (p<0.0001 for 9 out of 11 significantly expressed analytes). Glycosaminoglycans 46-49 interferon gamma Homo sapiens 133-142 21321110-7 2011 Our findings suggest that the pro-inflammatory cytokine IFN-gamma initiates a Duox2-mediated reactive oxygen cascade in human pancreatic cancer cells; reactive oxygen species production in this setting could contribute to the pathophysiologic characteristics of these tumors. reactive oxygen 93-108 interferon gamma Homo sapiens 56-65 21349366-3 2011 GMZ2 formulated in an oil-in-water emulsion plus the synthetic TLR4 agonist GLA elicits the highest (a) vaccine-specific IgG2a and total IgG titers, (b) parasite-specific IFA titers, (c) levels of Type 1 cytokine responses (IFN-gamma), and (d) number of long-lived-plasma cells (LLPC) secreting antibodies against both the GMZ2 fusion and its two components. gmz2 0-4 interferon gamma Homo sapiens 224-233 21321110-7 2011 Our findings suggest that the pro-inflammatory cytokine IFN-gamma initiates a Duox2-mediated reactive oxygen cascade in human pancreatic cancer cells; reactive oxygen species production in this setting could contribute to the pathophysiologic characteristics of these tumors. Reactive Oxygen Species 151-174 interferon gamma Homo sapiens 56-65 21143255-10 2011 Furthermore, ethanol-treated cells alone or in combination with LPS had significantly fewer IL-17- and IFN-gamma-secreting CD4+ T cells but constant proportion of Treg cells when compared to control cells. Ethanol 13-20 interferon gamma Homo sapiens 103-112 21382015-3 2011 In primary astrocytes and C6 glioma cells, BG-12 dose-dependently suppressed nitrite production induced by either LI [LPS (lipopolysaccharide) at 1 mug/ml plus IFNgamma (interferon gamma) at 20 units/ml] or a mixture of pro-inflammatory cytokines, with greater efficacy in C6 cells. Dimethyl Fumarate 43-48 interferon gamma Homo sapiens 160-168 21382015-3 2011 In primary astrocytes and C6 glioma cells, BG-12 dose-dependently suppressed nitrite production induced by either LI [LPS (lipopolysaccharide) at 1 mug/ml plus IFNgamma (interferon gamma) at 20 units/ml] or a mixture of pro-inflammatory cytokines, with greater efficacy in C6 cells. Dimethyl Fumarate 43-48 interferon gamma Homo sapiens 170-186 21276586-5 2011 Simvastatin and fenofibrate decreased monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and monocyte chemoattractant protein-1 and lymphocyte release of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha, which was accompanied by a decrease in plasma C-reactive protein levels. Simvastatin 0-11 interferon gamma Homo sapiens 201-250 21276586-5 2011 Simvastatin and fenofibrate decreased monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and monocyte chemoattractant protein-1 and lymphocyte release of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha, which was accompanied by a decrease in plasma C-reactive protein levels. Fenofibrate 16-27 interferon gamma Homo sapiens 201-250 21458658-7 2011 IFN-gamma protein production was also significantly lower in patients with ADEH(+) (n = 24) compared with patients with ADEH(-) (n = 20) and nonatopic controls (n = 20). adeh 75-79 interferon gamma Homo sapiens 0-9 21198545-9 2011 Vorinostat and romidepsin also increased expression of IFNG RNA and decreased expression of IL-2 and IL-4 RNA, although to a lesser extent compared to IL-10. Vorinostat 0-10 interferon gamma Homo sapiens 55-59 21195813-10 2011 We found that tacrolimus reduced levels of the IFN-gamma, IL-2, IL-10, and IL-13 cytokines and induced the proliferation of tolerogenic plasmacytoid dendritic cells after treatment. Tacrolimus 14-24 interferon gamma Homo sapiens 47-56 21458658-7 2011 IFN-gamma protein production was also significantly lower in patients with ADEH(+) (n = 24) compared with patients with ADEH(-) (n = 20) and nonatopic controls (n = 20). adeh 120-124 interferon gamma Homo sapiens 0-9 21458658-9 2011 Genetic variants in IFNG and IFNGR1 single nucleotide polymorphisms (SNPs) were significantly associated with ADEH (112 cases, 166 controls) and IFN-gamma production: a 2-SNP (A-G) IFNGR1 haplotype (rs10457655 and rs7749390) showed the strongest association with a reduced risk of ADEH+ (13.2% ADEH(+) vs 25.5% ADEH(-); P = .00057). adeh 110-114 interferon gamma Homo sapiens 20-24 21458658-9 2011 Genetic variants in IFNG and IFNGR1 single nucleotide polymorphisms (SNPs) were significantly associated with ADEH (112 cases, 166 controls) and IFN-gamma production: a 2-SNP (A-G) IFNGR1 haplotype (rs10457655 and rs7749390) showed the strongest association with a reduced risk of ADEH+ (13.2% ADEH(+) vs 25.5% ADEH(-); P = .00057). adeh+ 281-286 interferon gamma Homo sapiens 20-24 21458658-9 2011 Genetic variants in IFNG and IFNGR1 single nucleotide polymorphisms (SNPs) were significantly associated with ADEH (112 cases, 166 controls) and IFN-gamma production: a 2-SNP (A-G) IFNGR1 haplotype (rs10457655 and rs7749390) showed the strongest association with a reduced risk of ADEH+ (13.2% ADEH(+) vs 25.5% ADEH(-); P = .00057). adeh 281-285 interferon gamma Homo sapiens 20-24 21458658-9 2011 Genetic variants in IFNG and IFNGR1 single nucleotide polymorphisms (SNPs) were significantly associated with ADEH (112 cases, 166 controls) and IFN-gamma production: a 2-SNP (A-G) IFNGR1 haplotype (rs10457655 and rs7749390) showed the strongest association with a reduced risk of ADEH+ (13.2% ADEH(+) vs 25.5% ADEH(-); P = .00057). adeh 281-285 interferon gamma Homo sapiens 20-24 21627015-12 2011 MoDCs matured in the presence of Poly(I:C) up-regulated the production of IL-12 and IL-10, which was followed by increased levels of IFN-gamma and decreased levels of IL-5 in co-cultures with allogeneic CD4+ T cells. Poly I-C 33-42 interferon gamma Homo sapiens 133-142 21383649-7 2011 CsA C2 concentrations showed a significant (P < 0.01) correlation with the residual cytokine expression of interleukin-2, interferon-gamma, and granulocyte-macrophage colony-stimulating factor in both de novo and long-term patients, whereas CsA C0 concentrations did not. csa c2 0-6 interferon gamma Homo sapiens 125-195 21627015-17 2011 Treatment of Poly(I:C)-activated MoDCs with IFN-gamma down-regulated the production of IL-12 and up-regulated IL-10 by these cells and increased/decreased the levels of IL-10/ IFN-gamma, respectively, in co-culture with CD4+ T cells. Poly I-C 13-22 interferon gamma Homo sapiens 44-53 21627015-17 2011 Treatment of Poly(I:C)-activated MoDCs with IFN-gamma down-regulated the production of IL-12 and up-regulated IL-10 by these cells and increased/decreased the levels of IL-10/ IFN-gamma, respectively, in co-culture with CD4+ T cells. Poly I-C 13-22 interferon gamma Homo sapiens 176-185 21453513-6 2011 Expression of IFN-gamma Ralpha in the tumors was determined by immunohistochemistry analysis of paraffin-embedded tissues. Paraffin 96-104 interferon gamma Homo sapiens 14-23 21518503-1 2011 The aim of this study was to investigate the effect of brucine on secretion of TNF-alpha, IFN-gamma, IL-4 and proliferation of T lymphocytes in patients with aplastic anemia (AA), and to explore its mechanism. brucine 55-62 interferon gamma Homo sapiens 90-99 21518503-7 2011 The levels of TNF-alpha and IFN-gamma in the culture supernatant of brucine treated groups were lower, and were dependent on the concentration of brucine. brucine 68-75 interferon gamma Homo sapiens 28-37 21518503-7 2011 The levels of TNF-alpha and IFN-gamma in the culture supernatant of brucine treated groups were lower, and were dependent on the concentration of brucine. brucine 146-153 interferon gamma Homo sapiens 28-37 21435270-10 2011 CONCLUSION: AC inhibited T lymphocyte proliferation and decreased the gene expression of IL-2, IFN-gamma and NF-AT. arctigenin 12-14 interferon gamma Homo sapiens 95-104 21361338-3 2011 Most of the TCEs having two different kinds of nonenolizable cyano enones in rings A and C are highly potent suppressors of induction of inducible nitric oxide synthase stimulated with interferon-gamma and are highly potent inducers of the cytoprotective enzymes heme oxygenase-1 and NAD(P)H:quinone oxidoreductase-1. tces 12-16 interferon gamma Homo sapiens 185-201 21651851-7 2011 TER in IFN-gamma group and TNF-alpha group were gradually decreased during PTH 6-48, but showed no statistical difference as compared with that at PTH 0 (with F value respectively 1.69, 2.47, P values all above 0.05). pth 75-78 interferon gamma Homo sapiens 7-16 21651851-8 2011 TER in IFN-gamma plus TNF-alpha group was significantly decreased from PTH 24 as compared with that at PTH 0 (t = 4.97, P < 0.05) and that in each of the other three groups (F = 11.54, P < 0.05). pth 71-74 interferon gamma Homo sapiens 7-16 21651851-8 2011 TER in IFN-gamma plus TNF-alpha group was significantly decreased from PTH 24 as compared with that at PTH 0 (t = 4.97, P < 0.05) and that in each of the other three groups (F = 11.54, P < 0.05). pth 103-106 interferon gamma Homo sapiens 7-16 21435242-8 2011 The sIL-18Ralpha complex bound to the surface to the NK0 cell line, antagonized the stimulatory effects of IL-18 and IL-2 on the NK0 cell line and inhibited IFN-gamma production by the cells. sil-18ralpha 4-16 interferon gamma Homo sapiens 157-166 21418620-8 2011 In contrast, IL-7, IL-5, and Interferon (IFN)-gamma were decreased in both ICM and NIDCM groups as compared to controls. nidcm 83-88 interferon gamma Homo sapiens 29-51 21361338-3 2011 Most of the TCEs having two different kinds of nonenolizable cyano enones in rings A and C are highly potent suppressors of induction of inducible nitric oxide synthase stimulated with interferon-gamma and are highly potent inducers of the cytoprotective enzymes heme oxygenase-1 and NAD(P)H:quinone oxidoreductase-1. cyano enones 61-73 interferon gamma Homo sapiens 185-201 20473945-3 2011 Glycan-modification of antigen with GalNAc that mimics tumour-associated glycosylation, promoted antigen internalisation in DCs and presentation to CD4 T cells, as well as differentiation of IFN-gamma producing CD4 T cells. Polysaccharides 0-6 interferon gamma Homo sapiens 191-200 20473945-3 2011 Glycan-modification of antigen with GalNAc that mimics tumour-associated glycosylation, promoted antigen internalisation in DCs and presentation to CD4 T cells, as well as differentiation of IFN-gamma producing CD4 T cells. N-acetylgalactosaminuronic acid 36-42 interferon gamma Homo sapiens 191-200 20542267-0 2011 Heparin inhibits interferon-gamma signaling in human endometrial stromal cells by interference with the cellular binding of interferon-gamma. Heparin 0-7 interferon gamma Homo sapiens 17-33 20542267-0 2011 Heparin inhibits interferon-gamma signaling in human endometrial stromal cells by interference with the cellular binding of interferon-gamma. Heparin 0-7 interferon gamma Homo sapiens 124-140 20542267-1 2011 OBJECTIVE: To examine the impact of heparins on interferon-gamma (IFN-gamma) signaling in human endometrial stromal cells (ESCs) in vitro. Heparin 36-44 interferon gamma Homo sapiens 48-64 20542267-1 2011 OBJECTIVE: To examine the impact of heparins on interferon-gamma (IFN-gamma) signaling in human endometrial stromal cells (ESCs) in vitro. Heparin 36-44 interferon gamma Homo sapiens 66-75 20542267-9 2011 RESULT(S): Heparin and LMWHs inhibit the IFN-gamma-mediated induction of IRF-1, but not Nmi in undifferentiated and decidualized ESCs. Heparin 11-18 interferon gamma Homo sapiens 41-50 20542267-9 2011 RESULT(S): Heparin and LMWHs inhibit the IFN-gamma-mediated induction of IRF-1, but not Nmi in undifferentiated and decidualized ESCs. Heparin, Low-Molecular-Weight 23-28 interferon gamma Homo sapiens 41-50 20542267-11 2011 Heparin has no effect on the IFN-gamma receptor in ESCs, but inhibits the binding of IFN-gamma to the cells. Heparin 0-7 interferon gamma Homo sapiens 85-94 20542267-12 2011 CONCLUSION(S): Unfractionated heparin, as well as LMWHs, are able to inhibit IFN-gamma signaling in human ESCs and therefore might be clinically interesting agents to modulate the actions of this proinflammatory cytokine at the implantation site. Heparin 30-37 interferon gamma Homo sapiens 77-86 21183733-2 2011 In activated macrophages, IFN-gamma stimulates production of neopterin and conversion of tryptophan to kynurenine. Neopterin 61-70 interferon gamma Homo sapiens 26-35 21139574-10 2011 The addition of the anti-CD40L antibody to treated celiac biopsies significantly inhibited the PT-gliadin-induced production of IFN-gamma and IL-17, and mucosal T-bet. Platinum 95-97 interferon gamma Homo sapiens 128-137 21342445-4 2011 Upon CD3/CD28 stimulation, mycophenolic acid inhibited T cell IL-17, IFN-gamma and TNF-alpha production but not IL-2 production. Mycophenolic Acid 27-44 interferon gamma Homo sapiens 69-78 20812906-5 2011 Hyperforin, the non-polyphenolic compound present in St. John"s wort, attenuates β-cell death induced by interferon-γ (IFN-γ) by strongly down-regulating STAT1 activation. hyperforin 0-10 interferon gamma Homo sapiens 110-127 20812906-5 2011 Hyperforin, the non-polyphenolic compound present in St. John"s wort, attenuates β-cell death induced by interferon-γ (IFN-γ) by strongly down-regulating STAT1 activation. hyperforin 0-10 interferon gamma Homo sapiens 130-140 21183733-2 2011 In activated macrophages, IFN-gamma stimulates production of neopterin and conversion of tryptophan to kynurenine. Tryptophan 89-99 interferon gamma Homo sapiens 26-35 21183733-2 2011 In activated macrophages, IFN-gamma stimulates production of neopterin and conversion of tryptophan to kynurenine. Kynurenine 103-113 interferon gamma Homo sapiens 26-35 21145936-11 2011 Moreover, ATP increased the production of the proinflammatory cytokines interleukin-2, interferon-gamma, and interleukin-12p70, while decreasing the anti-inflammatory cytokine interleukin-10, and this finding was associated with the reduced ability of MSCs to inhibit T-cell proliferation. Adenosine Triphosphate 10-13 interferon gamma Homo sapiens 87-103 21436014-9 2011 RESULTS: Circulating T cells: IFN-gamma was significantly lower in the LAC-PD group (p<0.05) compared to the ICO-PD and LAC/BIC-PD groups. lac-pd 71-77 interferon gamma Homo sapiens 30-39 21436014-9 2011 RESULTS: Circulating T cells: IFN-gamma was significantly lower in the LAC-PD group (p<0.05) compared to the ICO-PD and LAC/BIC-PD groups. Lactose 71-74 interferon gamma Homo sapiens 30-39 21215285-6 2011 IL-10 -1082/-819/-592 and IFNG +874 SNPs were associated with the intensity of LP responses to C trachomatis antigens. leucylproline 79-81 interferon gamma Homo sapiens 26-30 21436014-9 2011 RESULTS: Circulating T cells: IFN-gamma was significantly lower in the LAC-PD group (p<0.05) compared to the ICO-PD and LAC/BIC-PD groups. bic-pd 127-133 interferon gamma Homo sapiens 30-39 21215285-7 2011 These cytokines also interact with each other and a cumulative effect of IL-10 -1082 and IFNG +874 genotypes was seen in LP responses to C trachomatis antigens. leucylproline 121-123 interferon gamma Homo sapiens 89-93 21278346-7 2011 When human monoblastic U937 cells were cultured in the presence of IFN-gamma, transcription of gp91-phox was remarkably upregulated, and the cells were differentiated to macrophage-like cells that can produce O(2)(-). Superoxides 209-213 interferon gamma Homo sapiens 67-76 20940323-9 2011 Based on the analysis of the cytokine/chemokine content of sDC-SIGN culture supernatants, we identified IFN-gamma and CXCL8/IL-8 as inducers of sDC-SIGN production by MoDC. S-[2-(Aminosulfonyl)ethyl]-D-Cysteine 59-62 interferon gamma Homo sapiens 104-113 20940323-9 2011 Based on the analysis of the cytokine/chemokine content of sDC-SIGN culture supernatants, we identified IFN-gamma and CXCL8/IL-8 as inducers of sDC-SIGN production by MoDC. S-[2-(Aminosulfonyl)ethyl]-D-Cysteine 144-147 interferon gamma Homo sapiens 104-113 21485100-7 2011 ROS stimulates alveolar macrophages and neutrophils to release inflammatory cytokines, such as TNF-alpha, IL-8, IFN-gamma, IL-6 and IL-1beta. Reactive Oxygen Species 0-3 interferon gamma Homo sapiens 112-121 21195724-4 2011 Erlotinib exerted a significant inhibition on the T cell proliferation and activation induced by concanavalin A, anti-CD3 plus anti-CD28, staphylococcal enterotoxin B or phorbol myristate acetate respectively in a concentration-dependent manner and it also inhibited the secretion of the proinflammatory cytokines such as IL-2 and IFN-gamma of activated T cells. Erlotinib Hydrochloride 0-9 interferon gamma Homo sapiens 331-340 20367796-8 2011 HBsAg-pulsed DC also produced significantly higher levels of IL-12 and IFN-gamma with lamivudine therapy compared to levels before therapy (P<0.05). Lamivudine 86-96 interferon gamma Homo sapiens 71-80 21440087-3 2011 The secretion of the pro-inflammatory cytokines IL-1beta and IFNgamma and that of the anti-inflammatory cytokines IL-1ra and IL-10 induced by cancer cells was decreased by simvastatin but not by pravastatin, whereas that of IL-6 was not affected by both drugs. Simvastatin 172-183 interferon gamma Homo sapiens 61-69 21185917-7 2011 Upon such stimulation with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma), adult porcine microglia, but not astrocytes, secrete tumor necrosis factor-alpha (TNF-alpha) while both cell types do not secrete detectable levels of nitric oxide (NO). Nitric Oxide 237-249 interferon gamma Homo sapiens 56-72 21185917-7 2011 Upon such stimulation with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma), adult porcine microglia, but not astrocytes, secrete tumor necrosis factor-alpha (TNF-alpha) while both cell types do not secrete detectable levels of nitric oxide (NO). Nitric Oxide 237-249 interferon gamma Homo sapiens 74-83 21149447-4 2011 Our data demonstrate that IFNgamma treatment of sensitive cells results in engagement of Mnk1, activation of its kinase domain, and downstream phosphorylation of the cap-binding protein eIF4E on Ser-209. Serine 195-198 interferon gamma Homo sapiens 26-34 21345222-8 2011 OPN301 significantly decreased Pam3CSK4-induced cytokine production of tumour necrosis factor alpha (TNF-alpha), IL-1beta, IL-6, interferon (IFN)-gamma and IL-8 compared to IgG control in RA PBMCs and SFMCs cultures (all P < 0.05). opn301 0-6 interferon gamma Homo sapiens 129-151 21320337-5 2011 RESULTS: Interferon-gamma ELISPOT assays showed a low frequency of weak responses to the rHBsAg and S peptide pool in the HBsAg seroclearance group, and the response frequency to the rHBcAg and the C peptide pool was higher than to the rHBsAg (P < 0.001) and S peptide pool (P = 0.001) respectively. rhbsag 89-95 interferon gamma Homo sapiens 9-25 21320337-5 2011 RESULTS: Interferon-gamma ELISPOT assays showed a low frequency of weak responses to the rHBsAg and S peptide pool in the HBsAg seroclearance group, and the response frequency to the rHBcAg and the C peptide pool was higher than to the rHBsAg (P < 0.001) and S peptide pool (P = 0.001) respectively. rhbcag 183-189 interferon gamma Homo sapiens 9-25 21320337-5 2011 RESULTS: Interferon-gamma ELISPOT assays showed a low frequency of weak responses to the rHBsAg and S peptide pool in the HBsAg seroclearance group, and the response frequency to the rHBcAg and the C peptide pool was higher than to the rHBsAg (P < 0.001) and S peptide pool (P = 0.001) respectively. rhbsag 236-242 interferon gamma Homo sapiens 9-25 21117621-7 2011 While all three cationic liposomes facilitated increased antigen presentation by antigen presenting cells, the monocyte infiltration to the SOI and the production of IFN-gamma upon antigen recall was markedly higher for DDA and DC-Chol based liposomes which exhibited a longer retention profile at the SOI. dimethyldioctadecylammonium 220-223 interferon gamma Homo sapiens 166-175 21117621-7 2011 While all three cationic liposomes facilitated increased antigen presentation by antigen presenting cells, the monocyte infiltration to the SOI and the production of IFN-gamma upon antigen recall was markedly higher for DDA and DC-Chol based liposomes which exhibited a longer retention profile at the SOI. 3-(N-(N',N'-dimethylaminoethane)carbamoyl)cholesterol 228-235 interferon gamma Homo sapiens 166-175 20973764-9 2011 alpha-NAC-specific TCC generated from lesional skin of AD predominantly produced interferon-gamma and some TCC also produced interleukin-17. alpha-nac 0-9 interferon gamma Homo sapiens 81-97 21098395-0 2011 Human neutrophils interact with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived IFN{gamma}: role of CD18, ICAM-1, and ICAM-3. 6-sulfo-LacNac 37-51 interferon gamma Homo sapiens 91-100 21130040-2 2011 At 0.03 muM to 1 muM, lenalidomide enhanced generation of IL-2 and IFN-gamma by T cell receptor-stimulated T cells of young subjects up to respective maximum increases of 17-fold and three-fold, but at 0.3 muM and 1 muM suppressed IL-17 generation. Lenalidomide 22-34 interferon gamma Homo sapiens 67-76 20852871-5 2011 Within 72 h rosuvastatin treatment significantly reduced mean CD4(+)CD28(null) T cell numbers (37 x 106/L vs. placebo 122 x 106/L, n = 20, P = 0.041), IFN-gamma production (62.6 vs. 101.5%, P = 0.049) and increased apoptosis of these T cells (63.4 vs. 12.3%, P < 0.001). Rosuvastatin Calcium 12-24 interferon gamma Homo sapiens 151-160 19943123-4 2011 Recently, interferon-gamma and the related pro-inflammatory interleukin-12 were found to be under effects of sex steroid hormones, with potential implications in regulating immune cells and autoimmune responses. Steroids 113-129 interferon gamma Homo sapiens 10-26 21145254-8 2011 In the obese women, serum transferrin receptor (a marker of iron status) and serum hepcidin were correlated with ex vivo stimulated IFNgamma production at baseline. Iron 60-64 interferon gamma Homo sapiens 132-140 21145254-11 2011 Furthermore, iron status and serum hepcidin were associated with ex vivo LPS and ZY stimulated IFNgamma in obesity. Iron 13-17 interferon gamma Homo sapiens 95-103 21130040-3 2011 The same concentrations of lenalidomide enhanced IL-2 and IFN-gamma generation by stimulated T cells of old subjects more, with greater respective maximal increases of up to 120-fold and six-fold, without suppressing IL-17 generation. Lenalidomide 27-39 interferon gamma Homo sapiens 58-67 21078360-8 2011 RESULTS: The combination of moderate-dose AMSCs and low-dose CsA was significantly more powerful than moderate-dose AMSCs or large-dose CsA alone in suppressing transcription and production of interleukin-2 and interferon-gamma, activation of NF-kappaB, and proliferation of T lymphocytes. Cyclosporine 61-64 interferon gamma Homo sapiens 211-227 21078360-8 2011 RESULTS: The combination of moderate-dose AMSCs and low-dose CsA was significantly more powerful than moderate-dose AMSCs or large-dose CsA alone in suppressing transcription and production of interleukin-2 and interferon-gamma, activation of NF-kappaB, and proliferation of T lymphocytes. Cyclosporine 136-139 interferon gamma Homo sapiens 211-227 20199580-4 2011 IFN-gamma concomitantly reduced mRNA expression of drug efflux pumps such as multidrug resistance gene 1, multidrug resistance protein (MRP) 2, MRP3, breast cancer resistance protein and bile salt export pump. Bile Acids and Salts 187-196 interferon gamma Homo sapiens 0-9 20940111-8 2011 Cord blood cytokines (IL-1beta, IL-8, IFNgamma, TNFalpha) showed a U-shaped association with U-As at GW30. u-as 93-97 interferon gamma Homo sapiens 38-46 20349206-4 2011 With RKO cells, aspirin reduced IL-6, IL-1ra, and IL-10 synthesis and enhanced IFNgamma secretion, while IL-1beta remained unchanged. Aspirin 16-23 interferon gamma Homo sapiens 79-87 20665705-7 2011 ApoL2 knockdown by siRNA promoted IFN-gamma-induced cytotoxicity as revealed by a significant drop in cell viability using MTT and CyQUANT NF cell proliferation assays, and a marked increase in hypodiploid sub-G1 cell population in cell cycle analysis. monooxyethylene trimethylolpropane tristearate 123-126 interferon gamma Homo sapiens 34-43 20665705-8 2011 Furthermore, depletion of ApoL2 facilitated IFN-gamma-induced membrane damage and chromatin condensation as observed in Hoechst and propidium iodide-double staining and in transmission electron microscopy, and DNA fragmentation using a DNA laddering assay, in a caspase-dependent manner. hoechst 120-127 interferon gamma Homo sapiens 44-53 20665705-8 2011 Furthermore, depletion of ApoL2 facilitated IFN-gamma-induced membrane damage and chromatin condensation as observed in Hoechst and propidium iodide-double staining and in transmission electron microscopy, and DNA fragmentation using a DNA laddering assay, in a caspase-dependent manner. Propidium 132-148 interferon gamma Homo sapiens 44-53 21245578-1 2011 Type 1 or invariant NKT (iNKT) cell agonists, epitomized by alpha-galactosylceramide, protect against cancer largely by IFN-gamma-dependent mechanisms. alpha-galactosylceramide 60-84 interferon gamma Homo sapiens 120-129 21245578-2 2011 Here we describe what we believe to be a novel IFN-gamma-independent mechanism induced by beta-mannosylceramide, which also defines a potentially new class of iNKT cell agonist, with an unusual beta-linked sugar. beta-Mannosylceramide 90-111 interferon gamma Homo sapiens 47-56 21245578-2 2011 Here we describe what we believe to be a novel IFN-gamma-independent mechanism induced by beta-mannosylceramide, which also defines a potentially new class of iNKT cell agonist, with an unusual beta-linked sugar. Sugars 206-211 interferon gamma Homo sapiens 47-56 21268089-0 2011 Molecular mechanisms underlying the inhibition of IFN-gamma-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. Simvastatin 127-138 interferon gamma Homo sapiens 50-59 21303487-0 2011 Importance of serine727 phosphorylated STAT1 in IFNgamma-induced signaling and apoptosis of human salivary gland cells. serine727 14-23 interferon gamma Homo sapiens 48-56 21303487-2 2011 The aim of this study is to clarify which phosphorylation of STAT1, serine727 (Ser(727)) or tyrosine701 (Tyr(701)) of STAT1, is important for IFNgamma signaling and IFNgamma-induced apoptosis in salivary gland cells. serine727 68-77 interferon gamma Homo sapiens 142-150 21303487-2 2011 The aim of this study is to clarify which phosphorylation of STAT1, serine727 (Ser(727)) or tyrosine701 (Tyr(701)) of STAT1, is important for IFNgamma signaling and IFNgamma-induced apoptosis in salivary gland cells. serine727 68-77 interferon gamma Homo sapiens 165-173 21303487-2 2011 The aim of this study is to clarify which phosphorylation of STAT1, serine727 (Ser(727)) or tyrosine701 (Tyr(701)) of STAT1, is important for IFNgamma signaling and IFNgamma-induced apoptosis in salivary gland cells. Serine 79-82 interferon gamma Homo sapiens 142-150 21303487-2 2011 The aim of this study is to clarify which phosphorylation of STAT1, serine727 (Ser(727)) or tyrosine701 (Tyr(701)) of STAT1, is important for IFNgamma signaling and IFNgamma-induced apoptosis in salivary gland cells. Serine 79-82 interferon gamma Homo sapiens 165-173 21268089-7 2011 These studies reveal differences in the mechanism of action of agonists of PPARs (and simvastatin) and LXRs on the IFN-gamma-induced, STAT1-mediated gene transcription in human macrophages. Simvastatin 86-97 interferon gamma Homo sapiens 115-124 21372495-6 2011 RESULTS: In ex vivo cultures, raloxifene therapy inhibited LPS-stimulated production of IL-1beta, IL-6, IL-12p40, IL-12p70 and TNF-alpha, but not PHA-stimulated production of IL-4 and IFN-gamma. Raloxifene Hydrochloride 30-40 interferon gamma Homo sapiens 184-193 21303487-2 2011 The aim of this study is to clarify which phosphorylation of STAT1, serine727 (Ser(727)) or tyrosine701 (Tyr(701)) of STAT1, is important for IFNgamma signaling and IFNgamma-induced apoptosis in salivary gland cells. tyrosine701 92-103 interferon gamma Homo sapiens 142-150 21303487-2 2011 The aim of this study is to clarify which phosphorylation of STAT1, serine727 (Ser(727)) or tyrosine701 (Tyr(701)) of STAT1, is important for IFNgamma signaling and IFNgamma-induced apoptosis in salivary gland cells. tyrosine701 92-103 interferon gamma Homo sapiens 165-173 21303487-2 2011 The aim of this study is to clarify which phosphorylation of STAT1, serine727 (Ser(727)) or tyrosine701 (Tyr(701)) of STAT1, is important for IFNgamma signaling and IFNgamma-induced apoptosis in salivary gland cells. Tyrosine 105-108 interferon gamma Homo sapiens 142-150 21303487-2 2011 The aim of this study is to clarify which phosphorylation of STAT1, serine727 (Ser(727)) or tyrosine701 (Tyr(701)) of STAT1, is important for IFNgamma signaling and IFNgamma-induced apoptosis in salivary gland cells. Tyrosine 105-108 interferon gamma Homo sapiens 165-173 21303487-5 2011 RESULTS: In Y701F mutant-STAT1 transfected HSG cells (Ser(727)-dominant HSG cells), IFNgamma-inducible genes such as IP10, IRF1, and Fas expression were increased after stimulation with IFNgamma. Serine 54-57 interferon gamma Homo sapiens 84-92 21303487-6 2011 In Ser(727)-dominant HSG cells, the induction of apoptosis after stimulation with IFNgamma was also increased compared with S727A mutant-STAT1 transfected HSG cells (Tyr(701)-dominant HSG cells). Serine 3-6 interferon gamma Homo sapiens 82-90 21303487-7 2011 CONCLUSION: Phosphorylation of Ser(727) in STAT1 might be more important in IFNgamma signaling and the induction of apoptosis in HSG cells than phosphorylation of Tyr(701). Serine 31-34 interferon gamma Homo sapiens 76-84 21372495-7 2011 In in vitro cultures, raloxifene at a concentration (10(-9) M) inhibited LPS-stimulated production of IL-1beta, IL-6 and IL-12p40 and PHA-stimulated production of IFN-gamma. Raloxifene Hydrochloride 22-32 interferon gamma Homo sapiens 163-172 20206950-2 2011 The aims of this study were (1) to study the mechanisms underlying the induction of CXCL10 secretion by cytokines in GD thyrocytes; (2) to test the effect of pioglitazone on IFNgamma-inducible CXCL10 secretion in primary thyrocytes, orbital fibroblasts, and preadipocytes from GD and GO patients; and (3) to evaluate the mechanism of action of thiazolidinediones on nuclear factor (NF)-kappaB activation. Pioglitazone 158-170 interferon gamma Homo sapiens 174-182 21161299-8 2011 IFNG and IFN-alpha transcriptionally induce indoleamine-2,3-dioxygenase (IDO), the rate-limiting enzyme of the kynurenine (KYN) pathway of tryptophan (TRY) metabolism. Kynurenine 111-121 interferon gamma Homo sapiens 0-4 21161299-8 2011 IFNG and IFN-alpha transcriptionally induce indoleamine-2,3-dioxygenase (IDO), the rate-limiting enzyme of the kynurenine (KYN) pathway of tryptophan (TRY) metabolism. Kynurenine 123-126 interferon gamma Homo sapiens 0-4 21161299-8 2011 IFNG and IFN-alpha transcriptionally induce indoleamine-2,3-dioxygenase (IDO), the rate-limiting enzyme of the kynurenine (KYN) pathway of tryptophan (TRY) metabolism. Tryptophan 139-149 interferon gamma Homo sapiens 0-4 21304967-11 2011 Among vaccinees, there was also a strong inverse association between IFNgamma response to M.tb PPD and vitamin D concentration, with infants with higher vitamin D concentrations having lower IFNgamma responses. tb ppd 92-98 interferon gamma Homo sapiens 69-77 20888416-6 2011 The active inhibitors also attenuated IFN-gamma-induced phosphorylation of Tyr(705)-STAT3 and astrocytic expression of intercellular adhesion molecule-1 (ICAM-1). Tyrosine 75-78 interferon gamma Homo sapiens 38-47 20974702-3 2011 We show here that the two metals have a divergent effect on peripheral T lymphocytes and monocytes: BeSO(4) induces cell death in monocytes but not in T lymphocytes, which instead respond by producing Interferon gamma (IFN-gamma); conversely, CoCl(2) induces apoptosis in T lymphocytes but not in monocytes. beryllium sulfate 100-107 interferon gamma Homo sapiens 201-217 20974702-3 2011 We show here that the two metals have a divergent effect on peripheral T lymphocytes and monocytes: BeSO(4) induces cell death in monocytes but not in T lymphocytes, which instead respond by producing Interferon gamma (IFN-gamma); conversely, CoCl(2) induces apoptosis in T lymphocytes but not in monocytes. beryllium sulfate 100-107 interferon gamma Homo sapiens 219-228 21220307-3 2011 Through induction of its regulatory protein, Cdk5R1 (p35), IFN-gamma activates Cdk5 to phosphorylate Ser(886) in the linker domain of glutamyl-prolyl tRNA synthetase (EPRS), the initial event in assembly of the GAIT complex. Serine 101-104 interferon gamma Homo sapiens 59-68 21304967-11 2011 Among vaccinees, there was also a strong inverse association between IFNgamma response to M.tb PPD and vitamin D concentration, with infants with higher vitamin D concentrations having lower IFNgamma responses. Vitamin D 103-112 interferon gamma Homo sapiens 69-77 21452414-8 2011 Thus, compared with the control group, patients with a history of BKVAN demonstrated significantly higher frequencies of interferon-gamma- and interleukin-2-producing effector memory CD4+ T cells. bkvan 66-71 interferon gamma Homo sapiens 121-137 21040785-5 2011 In GVHD patients, increasing arginine concentration resulted in down-regulation of IFNgamma and TNFalpha mRNA expression, whereas IL10 was up-regulated especially at physiological plasma levels (between 0 and 100 muM). Arginine 29-37 interferon gamma Homo sapiens 83-91 20929390-5 2011 AZT treatment decreased proliferation of unstimulated and Candida-stimulated PBMCs and IFN-gamma ELISPOT responses; 3TC decreased proliferation of unstimulated PBMCs only; d4T and TFV decreased proliferation of Candida-stimulated PBMCs only. Zidovudine 0-3 interferon gamma Homo sapiens 87-96 21232138-7 2011 We also determined the intratumoral cytokine and chemokine profile and found that alpha-TEA treatment increased intratumoral IFN-gamma levels but decreased interleukin (IL)-4 levels, suggesting a shift toward a TH1 response. 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid 82-91 interferon gamma Homo sapiens 125-134 20868777-3 2011 We assessed the optimal dose of alfacalcidol that could normalize the elevated levels of IFN-gamma expressed by the CD4+Th1 cells and the IL-17 expressed by Th17 cells. alfacalcidol 32-44 interferon gamma Homo sapiens 89-98 21083588-7 2011 Azathioprine therapy did not impair natural killer degranulation, but reduced natural and cytokine-activated cytotoxicity and interferon-gamma (IFN-gamma) production. Azathioprine 0-12 interferon gamma Homo sapiens 126-142 21083588-7 2011 Azathioprine therapy did not impair natural killer degranulation, but reduced natural and cytokine-activated cytotoxicity and interferon-gamma (IFN-gamma) production. Azathioprine 0-12 interferon gamma Homo sapiens 144-153 21083588-8 2011 Culture of resting peripheral blood mononuclear cells with azathioprine resulted in loss of natural killer cells and inhibition of activation and IFN-gamma production. Azathioprine 59-71 interferon gamma Homo sapiens 146-155 20482522-8 2011 CONCLUSION: IL-2 and IL-12 up-regulated the production of IFN-gamma in DMNC through increasing their susceptibility to LPS. dmnc 71-75 interferon gamma Homo sapiens 58-67 22282962-7 2011 Nigericin and valinomycin decreased the concentrations of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, and IL-17 in the culture medium with IC50 values less than 0.01 ng/ml. Nigericin 0-9 interferon gamma Homo sapiens 58-80 22282962-7 2011 Nigericin and valinomycin decreased the concentrations of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, and IL-17 in the culture medium with IC50 values less than 0.01 ng/ml. Valinomycin 14-25 interferon gamma Homo sapiens 58-80 21312365-0 2011 Effect of surfactant pluronic F-68 on CHO cell growth, metabolism, production, and glycosylation of human recombinant IFN-gamma in mild operating conditions. CAV protocol 38-41 interferon gamma Homo sapiens 118-127 21312365-2 2011 With two N-glycosylation sites, gamma-interferon (IFN-gamma) can be seen as a prototype of a recombinant therapeutic glycoprotein for this purpose. Nitrogen 9-10 interferon gamma Homo sapiens 50-59 21706923-0 2011 Optimising pre-analytical performance of interferon-gamma release assays for TB exposure. Terbium 77-79 interferon gamma Homo sapiens 41-57 20960187-6 2011 A log-rank comparison of survival for patients whose TCs were found to be either sensitive (upregulated phosphatidylserine and calreticulin) or insensitive to IFN-gamma revealed a strongly significant correlation to progression-free (p = 0.003) and overall survival (p = 0.002) favorably in those patients whose cell lines were resistant to the proapoptotic effect of IFN-gamma. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide 53-56 interferon gamma Homo sapiens 368-377 21052994-10 2011 Three days of daunorubicin treatment resulted in enhanced antigen expression by tumor cells, in turn inducing co-cultured antigen-specific T cells to secrete Interleukin-2 and Interferon-gamma. Daunorubicin 14-26 interferon gamma Homo sapiens 176-192 21802664-3 2011 Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production. Poly I-C 42-73 interferon gamma Homo sapiens 295-304 21802664-4 2011 Neutralization of IFN-gamma blocks poly I:C plus inflammatory cytokines-induced NK cell TRAIL expression, suggesting that IFN-gamma is an autocrine differentiation factor for these cells. Poly I 35-41 interferon gamma Homo sapiens 122-131 21802664-4 2011 Neutralization of IFN-gamma blocks poly I:C plus inflammatory cytokines-induced NK cell TRAIL expression, suggesting that IFN-gamma is an autocrine differentiation factor for these cells. Carbon 42-43 interferon gamma Homo sapiens 18-27 21802664-4 2011 Neutralization of IFN-gamma blocks poly I:C plus inflammatory cytokines-induced NK cell TRAIL expression, suggesting that IFN-gamma is an autocrine differentiation factor for these cells. Carbon 42-43 interferon gamma Homo sapiens 122-131 21802664-3 2011 Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production. Poly I-C 42-73 interferon gamma Homo sapiens 407-416 21889126-3 2011 We found that atorvastatin ameliorated the clinical symptoms of EAN, decreased the numbers of inflammatory cells as well as IFN-gamma(+) and IL-17(+) cells in sciatic nerves, decreased the CD80 expression and increased the number of CD25(+)Foxp3(+) cells in mononuclear cells (MNC), and decreased the levels of IFN-gamma in MNC culture supernatants. Atorvastatin 14-26 interferon gamma Homo sapiens 124-133 21889126-3 2011 We found that atorvastatin ameliorated the clinical symptoms of EAN, decreased the numbers of inflammatory cells as well as IFN-gamma(+) and IL-17(+) cells in sciatic nerves, decreased the CD80 expression and increased the number of CD25(+)Foxp3(+) cells in mononuclear cells (MNC), and decreased the levels of IFN-gamma in MNC culture supernatants. Atorvastatin 14-26 interferon gamma Homo sapiens 311-320 21802664-3 2011 Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production. Poly I-C 75-83 interferon gamma Homo sapiens 295-304 21802664-3 2011 Our results show that the synthetic dsRNA polyinosinic-polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-gamma production and TRAIL expression, and anti-inflammatory cytokines (TGF-beta and IL-10) inhibit NK cell IFN-gamma production. Poly I-C 75-83 interferon gamma Homo sapiens 407-416 21802664-4 2011 Neutralization of IFN-gamma blocks poly I:C plus inflammatory cytokines-induced NK cell TRAIL expression, suggesting that IFN-gamma is an autocrine differentiation factor for these cells. Poly I 35-41 interferon gamma Homo sapiens 18-27 22606516-2 2011 Lymphocyte blast transformation (LBT), a method of detecting cellular immune response by measuring levels of interferon-gamma (IFN-gamma), was used to diagnose vancomycin hypersensitivity and guide antibiotic selection. Vancomycin 160-170 interferon gamma Homo sapiens 109-125 22606516-2 2011 Lymphocyte blast transformation (LBT), a method of detecting cellular immune response by measuring levels of interferon-gamma (IFN-gamma), was used to diagnose vancomycin hypersensitivity and guide antibiotic selection. Vancomycin 160-170 interferon gamma Homo sapiens 127-136 21669042-5 2011 We found that PDMCs are more resistant to NK-mediated lysis than the major histocompatibility complex (MHC) class-I null target cell K562, and can suppress NK secretion of interferon-gamma (IFN-gamma). pdmcs 14-19 interferon gamma Homo sapiens 190-199 21669042-5 2011 We found that PDMCs are more resistant to NK-mediated lysis than the major histocompatibility complex (MHC) class-I null target cell K562, and can suppress NK secretion of interferon-gamma (IFN-gamma). pdmcs 14-19 interferon gamma Homo sapiens 172-188 21669042-9 2011 Moreover, enhancement of PDMC suppressive effects is also mediated by IFN-gamma-induced surface expression of HLA-G--an immunomodulatory nonclassical MHC class I molecule--on PDMCs, as seen by partial reversibility with HLA-G neutralizing antibodies. pdmc 25-29 interferon gamma Homo sapiens 70-79 21669042-9 2011 Moreover, enhancement of PDMC suppressive effects is also mediated by IFN-gamma-induced surface expression of HLA-G--an immunomodulatory nonclassical MHC class I molecule--on PDMCs, as seen by partial reversibility with HLA-G neutralizing antibodies. pdmcs 175-180 interferon gamma Homo sapiens 70-79 21078084-11 2011 Contrary to previous reports, IFN-gamma alone induced apoptosis in IEC lines, as demonstrated by phosphatidylserin staining, DNA cleavage and LDH release. phosphatidylserin 97-114 interferon gamma Homo sapiens 30-39 21547034-4 2011 These reactivities were predictable before transplantation, using an MLR-ELISPOT (mixed lymphocyte reaction; enzyme-linked immunospot) assay by comparing the number of IFNgamma-producing cells stimulated with NIMA. nima 209-213 interferon gamma Homo sapiens 168-176 19906427-7 2011 In the calves vaccinated with either pVAX-tgD (Vaccine A) or pVAX-tgD combined with pVAX-48CpG (Vaccine B), BoHV-1-specific IFN-gamma secreting cells were detected in PBMCs 90 days after the first vaccination and their number increased after challenge exposure. pvax-48cpg 84-94 interferon gamma Homo sapiens 124-133 21106878-6 2011 Treatment with methyl or ethyl pyruvate partially protected against the LPS/IFNgamma-induced fall in mTOR signaling. methyl radical 15-21 interferon gamma Homo sapiens 76-84 21106878-6 2011 Treatment with methyl or ethyl pyruvate partially protected against the LPS/IFNgamma-induced fall in mTOR signaling. ethyl pyruvate 25-39 interferon gamma Homo sapiens 76-84 21106878-10 2011 Ethyl pyruvate also restored IGF-I-stimulated protein synthesis in LPS/IFNgamma-treated myotubes. ethyl pyruvate 0-14 interferon gamma Homo sapiens 71-79 21227887-0 2011 Effects of tacrolimus on IFN-gamma signaling in keratinocytes: possible mechanisms by which tacrolimus affects IFN-gamma-dependent skin inflammation. Tacrolimus 11-21 interferon gamma Homo sapiens 25-34 21227887-0 2011 Effects of tacrolimus on IFN-gamma signaling in keratinocytes: possible mechanisms by which tacrolimus affects IFN-gamma-dependent skin inflammation. Tacrolimus 92-102 interferon gamma Homo sapiens 25-34 21227887-0 2011 Effects of tacrolimus on IFN-gamma signaling in keratinocytes: possible mechanisms by which tacrolimus affects IFN-gamma-dependent skin inflammation. Tacrolimus 92-102 interferon gamma Homo sapiens 111-120 21227887-3 2011 This study explored the mechanism of tacrolimus-modulated IFN-gamma signal transduction in HaCaT keratinocytes and the effects of tacrolimus on IFN-gamma-associated cytokine production in HaCaT cells. Tacrolimus 37-47 interferon gamma Homo sapiens 58-67 21227887-3 2011 This study explored the mechanism of tacrolimus-modulated IFN-gamma signal transduction in HaCaT keratinocytes and the effects of tacrolimus on IFN-gamma-associated cytokine production in HaCaT cells. Tacrolimus 130-140 interferon gamma Homo sapiens 144-153 21227887-4 2011 Tacrolimus down-regulated the recombinant human IFN-gamma (rhIFN-gamma)-induced expression of IFN-gamma receptor alpha (IFN-gammaRalpha). Tacrolimus 0-10 interferon gamma Homo sapiens 48-57 21227887-4 2011 Tacrolimus down-regulated the recombinant human IFN-gamma (rhIFN-gamma)-induced expression of IFN-gamma receptor alpha (IFN-gammaRalpha). Tacrolimus 0-10 interferon gamma Homo sapiens 61-70 21227887-5 2011 The IFN-gamma induced expression of phosphorylated Janus kinase 2 (pJAK2) and phosphorylated signal transducer and activator of transcription-1 (pSTAT-1) was also inhibited by tacrolimus. Tacrolimus 176-186 interferon gamma Homo sapiens 4-13 21227887-6 2011 Tacrolimus up-regulated the IFN-gamma-induced expression of suppressor of cytokine signaling-1 (SOCS-1). Tacrolimus 0-10 interferon gamma Homo sapiens 28-37 21227887-7 2011 Tacrolimus was also demonstrated to down-regulate IFN-gamma-induced the secretion of chemotactic factor CXCL-8 and the expression of intercellular adhesion molecule-1 and human leucocyte antigen HLA-DR. Tacrolimus 0-10 interferon gamma Homo sapiens 50-59 21227887-8 2011 The findings in this work indicate that the direct effects of tacrolimus on IFN-gamma signaling in keratinocytes may contribute to its therapeutic efficacy as a topical ointment in the treatment of IFN-gamma-dependent skin inflammation. Tacrolimus 62-72 interferon gamma Homo sapiens 76-85 21227887-8 2011 The findings in this work indicate that the direct effects of tacrolimus on IFN-gamma signaling in keratinocytes may contribute to its therapeutic efficacy as a topical ointment in the treatment of IFN-gamma-dependent skin inflammation. Tacrolimus 62-72 interferon gamma Homo sapiens 198-207 21227895-2 2011 In the present study we investigated the effect of systemic photochemotherapy (PUVA therapy- psoralen and UVA therapy) on the expression of IFN-gamma, IL-12p40 and IL-23p19 in lesional psoriatic skin. puva 79-83 interferon gamma Homo sapiens 140-149 21227895-6 2011 The immunosuppressive effect of PUVA therapy presented with decreased expression of biologically active IL-23 (IL-12/IL-23p40 + IL-23p19) as a part of the Th17 pathway, and IFN-gamma (Th1 pathway) led, in our patients, to a marked clinical improvement as shown by PASI (before therapy 20.55 and after therapy 3.33). puva 32-36 interferon gamma Homo sapiens 173-182 20722064-9 2011 Addition of ATP to flagellin caused greater weight loss and increased antiflagellin antibody titers, as well as decreased colonic interferon gamma (IFN-gamma) and higher antiflagellin IgG1/IgG2 ratios, which indicate decreased Th1 polarization. Adenosine Triphosphate 12-15 interferon gamma Homo sapiens 130-157 21046567-8 2011 We demonstrate that GABA suppresses the reactive response of both astrocytes and microglia to the inflammatory stimulants lipopolysaccharide (LPS) and interferon-gamma by inhibiting induction of inflammatory pathways mediated by NFkappaB and P38 MAP kinase. gamma-Aminobutyric Acid 20-24 interferon gamma Homo sapiens 151-167 21496413-5 2011 In animal models and in vitro models, after treatment with Bosentan, a significant reduction of cytokine (TNF alpha, IFN gamma,IL-8, IL-4) levels was observed. Bosentan 59-67 interferon gamma Homo sapiens 117-126 21597298-9 2011 A similar effect was observed in non-atopic controls except that AZM did inhibit IFN-gamma production of their Th0 cells. Azithromycin 65-68 interferon gamma Homo sapiens 81-90 22114506-6 2011 RESULTS: The splenocyte viability and the production of interleukin-2 and interleukin-4 were unaffected, whereas interferon-gamma production was markedly attenuated by iron oxide nanoparticles (10-100 mug iron/mL) in a concentration-dependent manner. ferric oxide 168-178 interferon gamma Homo sapiens 113-129 22114506-6 2011 RESULTS: The splenocyte viability and the production of interleukin-2 and interleukin-4 were unaffected, whereas interferon-gamma production was markedly attenuated by iron oxide nanoparticles (10-100 mug iron/mL) in a concentration-dependent manner. Iron 168-172 interferon gamma Homo sapiens 113-129 22114506-8 2011 The effects of iron oxide nanoparticles on interferon-gamma and glutathione were attenuated by the presence of N-acetyl-L-cysteine, a precursor of glutathione. ferric oxide 15-25 interferon gamma Homo sapiens 43-59 22114506-8 2011 The effects of iron oxide nanoparticles on interferon-gamma and glutathione were attenuated by the presence of N-acetyl-L-cysteine, a precursor of glutathione. Acetylcysteine 111-130 interferon gamma Homo sapiens 43-59 22114506-8 2011 The effects of iron oxide nanoparticles on interferon-gamma and glutathione were attenuated by the presence of N-acetyl-L-cysteine, a precursor of glutathione. Glutathione 147-158 interferon gamma Homo sapiens 43-59 22114506-11 2011 In addition, the suppressive effect of iron oxide nanoparticles on interferon-gamma was closely associated with the diminishment of glutathione. ferric oxide 39-49 interferon gamma Homo sapiens 67-83 22114506-11 2011 In addition, the suppressive effect of iron oxide nanoparticles on interferon-gamma was closely associated with the diminishment of glutathione. Glutathione 132-143 interferon gamma Homo sapiens 67-83 21496413-11 2011 Bosentan significantly reduced IL-2, IL-6, IL-8 and IFN- gamma levels in SSc patients, probably slowing progression to fibrosis and vascular damage. Bosentan 0-8 interferon gamma Homo sapiens 52-62 20811799-0 2011 Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. Kynurenine 27-38 interferon gamma Homo sapiens 0-16 20625996-0 2011 Reactive oxygen species are involved in the IFN-gamma-stimulated production of Th2 chemokines in HaCaT keratinocytes. Reactive Oxygen Species 0-23 interferon gamma Homo sapiens 44-53 20625996-3 2011 Here, we investigated the function of ROS in the production of these two Th2 chemokines in interferon-gamma (IFN-gamma)-treated HaCaT keratinocytes. Reactive Oxygen Species 38-41 interferon gamma Homo sapiens 91-107 20625996-3 2011 Here, we investigated the function of ROS in the production of these two Th2 chemokines in interferon-gamma (IFN-gamma)-treated HaCaT keratinocytes. Reactive Oxygen Species 38-41 interferon gamma Homo sapiens 109-118 20625996-4 2011 We found that IFN-gamma-induced production of both chemokines in parallel with the increased generation of intracellular ROS. Reactive Oxygen Species 121-124 interferon gamma Homo sapiens 14-23 20625996-5 2011 A ROS scavenger, N-acetyl cysteine (NAC), significantly inhibited the IFN-gamma-induced production of chemokines as well as the activation of I kappa-B (IkappaB)-nuclear factor-kappa B (NF-kappaB). Reactive Oxygen Species 2-5 interferon gamma Homo sapiens 70-79 20625996-5 2011 A ROS scavenger, N-acetyl cysteine (NAC), significantly inhibited the IFN-gamma-induced production of chemokines as well as the activation of I kappa-B (IkappaB)-nuclear factor-kappa B (NF-kappaB). Acetylcysteine 17-34 interferon gamma Homo sapiens 70-79 20625996-5 2011 A ROS scavenger, N-acetyl cysteine (NAC), significantly inhibited the IFN-gamma-induced production of chemokines as well as the activation of I kappa-B (IkappaB)-nuclear factor-kappa B (NF-kappaB). Acetylcysteine 36-39 interferon gamma Homo sapiens 70-79 20625996-8 2011 Importantly, IFN-gamma-stimulated phosphorylation of p38 MAPK was significantly suppressed by JAKs inhibitors, but not significantly affected by NAC or L-buthionine sulfoximine (L-BSO). Buthionine Sulfoximine 178-183 interferon gamma Homo sapiens 13-22 20625996-9 2011 However, IFN-gamma-stimulated activation of IkappaB and NF-kappaB was suppressed by NAC but enhanced by BSO. Acetylcysteine 84-87 interferon gamma Homo sapiens 9-18 20625996-11 2011 These results indicate that intracellular ROS and JAKs/p38 MAPK both contribute independently to IFN-gamma-stimulated production of TARC and MDC in HaCaT keratinocytes, by increasing NF-kappaB activation. Reactive Oxygen Species 42-45 interferon gamma Homo sapiens 97-106 20811799-0 2011 Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. Pteridines 39-49 interferon gamma Homo sapiens 0-16 20811799-1 2011 This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment). Tryptophan 148-158 interferon gamma Homo sapiens 80-96 20811799-1 2011 This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment). Tryptophan 148-158 interferon gamma Homo sapiens 98-102 20811799-1 2011 This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment). Kynurenine 165-175 interferon gamma Homo sapiens 80-96 20811799-1 2011 This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment). Kynurenine 165-175 interferon gamma Homo sapiens 98-102 20811799-1 2011 This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment). Kynurenine 177-180 interferon gamma Homo sapiens 80-96 20811799-1 2011 This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment). Kynurenine 177-180 interferon gamma Homo sapiens 98-102 20811799-1 2011 This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment). guanine-tetrahydrobiopterin 186-213 interferon gamma Homo sapiens 80-96 20811799-1 2011 This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment). guanine-tetrahydrobiopterin 186-213 interferon gamma Homo sapiens 98-102 20811799-1 2011 This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment). sapropterin 215-218 interferon gamma Homo sapiens 80-96 20811799-1 2011 This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment). sapropterin 215-218 interferon gamma Homo sapiens 98-102 20811799-2 2011 IFNG-inducible KYN/pteridines inflammation cascade is characterized by up-regulation of nitric oxide synthase (NOS) activity (induced by KYN) and decreased formation of NOS cofactor, BH4, that results in uncoupling of NOS that shifting arginine from NO to superoxide anion production. Kynurenine 15-18 interferon gamma Homo sapiens 0-4 20811799-2 2011 IFNG-inducible KYN/pteridines inflammation cascade is characterized by up-regulation of nitric oxide synthase (NOS) activity (induced by KYN) and decreased formation of NOS cofactor, BH4, that results in uncoupling of NOS that shifting arginine from NO to superoxide anion production. Pteridines 19-29 interferon gamma Homo sapiens 0-4 20811799-2 2011 IFNG-inducible KYN/pteridines inflammation cascade is characterized by up-regulation of nitric oxide synthase (NOS) activity (induced by KYN) and decreased formation of NOS cofactor, BH4, that results in uncoupling of NOS that shifting arginine from NO to superoxide anion production. Kynurenine 137-140 interferon gamma Homo sapiens 0-4 20811799-2 2011 IFNG-inducible KYN/pteridines inflammation cascade is characterized by up-regulation of nitric oxide synthase (NOS) activity (induced by KYN) and decreased formation of NOS cofactor, BH4, that results in uncoupling of NOS that shifting arginine from NO to superoxide anion production. sapropterin 183-186 interferon gamma Homo sapiens 0-4 20811799-2 2011 IFNG-inducible KYN/pteridines inflammation cascade is characterized by up-regulation of nitric oxide synthase (NOS) activity (induced by KYN) and decreased formation of NOS cofactor, BH4, that results in uncoupling of NOS that shifting arginine from NO to superoxide anion production. Arginine 236-244 interferon gamma Homo sapiens 0-4 20811799-2 2011 IFNG-inducible KYN/pteridines inflammation cascade is characterized by up-regulation of nitric oxide synthase (NOS) activity (induced by KYN) and decreased formation of NOS cofactor, BH4, that results in uncoupling of NOS that shifting arginine from NO to superoxide anion production. Superoxides 256-272 interferon gamma Homo sapiens 0-4 20811799-4 2011 IFNG-induced up-regulation of indoleamine 2,3-dioxygenase (IDO), rate-limiting enzyme of TRY-KYN pathway, decreases TRY conversion into serotonin (substrate of antidepressant effect) and increases production of KYN associated with diabetes [xanthurenic acid (XA)], anxiety (KYN), psychoses and cognitive impairment (kynurenic acid). Serotonin 136-145 interferon gamma Homo sapiens 0-4 20811799-4 2011 IFNG-induced up-regulation of indoleamine 2,3-dioxygenase (IDO), rate-limiting enzyme of TRY-KYN pathway, decreases TRY conversion into serotonin (substrate of antidepressant effect) and increases production of KYN associated with diabetes [xanthurenic acid (XA)], anxiety (KYN), psychoses and cognitive impairment (kynurenic acid). xanthurenic acid 241-257 interferon gamma Homo sapiens 0-4 20811799-4 2011 IFNG-induced up-regulation of indoleamine 2,3-dioxygenase (IDO), rate-limiting enzyme of TRY-KYN pathway, decreases TRY conversion into serotonin (substrate of antidepressant effect) and increases production of KYN associated with diabetes [xanthurenic acid (XA)], anxiety (KYN), psychoses and cognitive impairment (kynurenic acid). Kynurenine 93-96 interferon gamma Homo sapiens 0-4 20811799-4 2011 IFNG-induced up-regulation of indoleamine 2,3-dioxygenase (IDO), rate-limiting enzyme of TRY-KYN pathway, decreases TRY conversion into serotonin (substrate of antidepressant effect) and increases production of KYN associated with diabetes [xanthurenic acid (XA)], anxiety (KYN), psychoses and cognitive impairment (kynurenic acid). Kynurenic Acid 316-330 interferon gamma Homo sapiens 0-4 20811799-5 2011 IFNG-inducible KYN/pteridines inflammation cascade is impacted by IFNG (+874) T/A genotypes, encoding cytokine production. Kynurenine 15-18 interferon gamma Homo sapiens 0-4 20811799-5 2011 IFNG-inducible KYN/pteridines inflammation cascade is impacted by IFNG (+874) T/A genotypes, encoding cytokine production. Kynurenine 15-18 interferon gamma Homo sapiens 66-70 20811799-5 2011 IFNG-inducible KYN/pteridines inflammation cascade is impacted by IFNG (+874) T/A genotypes, encoding cytokine production. Pteridines 19-29 interferon gamma Homo sapiens 0-4 20811799-5 2011 IFNG-inducible KYN/pteridines inflammation cascade is impacted by IFNG (+874) T/A genotypes, encoding cytokine production. Pteridines 19-29 interferon gamma Homo sapiens 66-70 20811799-7 2011 IFNG-inducible cascade is influenced by environmental factors (e.g., vitamin B6 deficiency increases XA formation) and by pharmacological agents; and might offer new approaches for anti-aging and anti-AAMPD interventions. Vitamin B 6 69-79 interferon gamma Homo sapiens 0-4 20938210-9 2011 The lymphocyte cAMP level was negatively correlated with the IFN-gamma/IL-10 ratio (p < 0.01). Cyclic AMP 15-19 interferon gamma Homo sapiens 61-70 21986138-4 2011 IFN-gamma production was also measured after addition of L-arginine and/or antitransforming growth factor-beta (TGF-beta) neutralizing monoclonal antibody, and in PBMCs depleted of CD14(+)HLA-DR(-/low) cells. Arginine 57-67 interferon gamma Homo sapiens 0-9 21112094-3 2011 We have previously demonstrated that IFN-gamma inhibits EVT invasion via a mechanism partially dependent on an increase in EVT apoptosis and decreased secretion of matrix metalloproteinase (MMP)-2. EVT 56-59 interferon gamma Homo sapiens 37-46 21112094-3 2011 We have previously demonstrated that IFN-gamma inhibits EVT invasion via a mechanism partially dependent on an increase in EVT apoptosis and decreased secretion of matrix metalloproteinase (MMP)-2. EVT 123-126 interferon gamma Homo sapiens 37-46 21112094-4 2011 In the current study we show that TNF-alpha, both alone and in combination with IFN-gamma, inhibits EVT invasion via a mechanism associated with increased trophoblast apoptosis, decreased trophoblast proliferation and/or altered production of active proteases. EVT 100-103 interferon gamma Homo sapiens 80-89 21112094-8 2011 The combination of TNF-alpha and IFN-gamma inhibited EVT via a mechanism associated with increased EVT apoptosis, reduced proliferation, reduced pro-MMP-2 secretion and increased secretion of uPA. EVT 53-56 interferon gamma Homo sapiens 33-42 21112094-8 2011 The combination of TNF-alpha and IFN-gamma inhibited EVT via a mechanism associated with increased EVT apoptosis, reduced proliferation, reduced pro-MMP-2 secretion and increased secretion of uPA. EVT 99-102 interferon gamma Homo sapiens 33-42 21112094-10 2011 The mode of activity of TNF-alpha was modified by the presence of IFN-gamma, suggesting that the local cytokine milieu may be critical in determining spatial and/or temporal changes in EVT invasion. EVT 185-188 interferon gamma Homo sapiens 66-75 21576995-4 2011 In contrast to IL-17, IFN-gamma showed significant reduction after 12 weeks of treatment with pegylated IFN plus ribavirin. Ribavirin 113-122 interferon gamma Homo sapiens 22-31 21576995-6 2011 CONCLUSION: Our findings suggest that the combined treatment with pegylated IFN-alpha and ribavirin downmodulates the secretion of key cytokine IFN-gamma as early as 12 weeks after treatment in infected patients. Ribavirin 90-99 interferon gamma Homo sapiens 144-153 20938210-10 2011 After treatment with metoprolol and carvedilol, the IFN-gamma/IL-10 ratio in the CHF patients was dramatically decreased (p < 0.01 for each drug) and lymphocyte cAMP was remarkably increased (p < 0.01 for each drug). Metoprolol 21-31 interferon gamma Homo sapiens 52-61 20938210-10 2011 After treatment with metoprolol and carvedilol, the IFN-gamma/IL-10 ratio in the CHF patients was dramatically decreased (p < 0.01 for each drug) and lymphocyte cAMP was remarkably increased (p < 0.01 for each drug). Carvedilol 36-46 interferon gamma Homo sapiens 52-61 22066031-11 2011 CONCLUSION: Anti-M2R AAbs and IFN-gamma raise early during chagasic infection in children and are downmodulated by BZ therapy. benzonidazole 115-117 interferon gamma Homo sapiens 30-39 21057930-2 2011 The output of an ELISpot assay is a formation of colored spots which appear at the sites of cells releasing cytokines, with each individual spot representing a single cytokine-releasing cell.We have shown that hydrogen peroxide-induced oxidative stress was causing ~twofold decrease in the number of lymphocytes secreting the TH1 cytokines IFN-gamma and IL-2, as well as chemokine IL-8 and cytokine TNF alpha. Hydrogen Peroxide 210-227 interferon gamma Homo sapiens 340-349 21057930-5 2011 We adopted ELISpot assay for studying oxidative stress in human peripheral blood lymphocytes by analyzing the acute effect of hydrogen peroxide treatment on the frequency of cells secreting IFN-gamma, IL-2, IL-4, IL-5, IL-8, and TNF-alpha. Hydrogen Peroxide 126-143 interferon gamma Homo sapiens 190-199 22180355-0 2011 IFN-gamma suppresses the high glucose-induced increase in TGF-beta1 and CTGF synthesis in mesangial cells. Glucose 30-37 interferon gamma Homo sapiens 0-9 22180355-3 2011 Here, we focus on the effects of IFN-gamma on human mesangial cells (HMCs) treated with high glucose. Glucose 93-100 interferon gamma Homo sapiens 33-42 22180355-4 2011 This study shows that IFN-gamma phosphorylates STAT1, suppresses HMC proliferation, and downregulates mRNA and protein levels of transforming growth factor-beta1 (TGF-beta1) and connective tissue growth factor (CTGF) in HMCs treated with high glucose. Glucose 243-250 interferon gamma Homo sapiens 22-31 22180355-6 2011 These data indicate that IFN-gamma could activate STAT1 to suppress the increase in TGF-beta1 and CTGF synthesis in HMCs induced by high glucose. Glucose 137-144 interferon gamma Homo sapiens 25-34 21998698-5 2011 RTS,S/ AS01(E) vaccinees had higher frequencies of CS-specific CD4+ T cells producing IFNgamma, TNFalpha or IL2 compared to control vaccinees. Cesium 51-53 interferon gamma Homo sapiens 86-94 21857901-8 2011 T-cell responses, detected by interferon-gamma (IFN-gamma) ELISpot to global potential T-cell epitopes (PTEs) were observed in 70.8% (136/192) of vaccine recipients overall, most frequently to Gag (54.7%) and to Env (54.2%). Glycosaminoglycans 193-196 interferon gamma Homo sapiens 48-57 21731667-2 2011 In response to infection, interferon-gamma activates indoleamine 2,3-dioxygenase (IDO) which metabolizes the essential amino acid tryptophan to the toxic metabolite kynurenine. essential amino acid tryptophan 109-140 interferon gamma Homo sapiens 26-42 21731667-2 2011 In response to infection, interferon-gamma activates indoleamine 2,3-dioxygenase (IDO) which metabolizes the essential amino acid tryptophan to the toxic metabolite kynurenine. Kynurenine 165-175 interferon gamma Homo sapiens 26-42 21473113-5 2011 We found that LDCI-chemotherapy (lomustine, dacarbazine, cisplatin and interferon gamma), induced AP sites and DNA ss-breaks which repaired trough BER pathway. ldci 14-18 interferon gamma Homo sapiens 71-87 21858117-11 2011 Finally, we found that Nef counteracted the IFN-gamma induced arachidonic acid cascade. Arachidonic Acid 62-78 interferon gamma Homo sapiens 44-53 21809660-4 2011 These parameters were assessed in lymphocytes sampled from the blood of patients with metastatic cutaneous melanoma before and after one cycle of chemotherapy with lomustine, dacarbazine, cisplatin and interferon-gamma (LDCI). ldci 220-224 interferon gamma Homo sapiens 202-218 22567271-3 2011 The relationship between immunocompetence and interferon (IFN)-gamma response in QuantiFERON-TB Gold (QFT) is uncertain, especially in HIV-negative populations. tb gold 93-100 interferon gamma Homo sapiens 46-68 21149724-3 2010 The Th1 cytokine IFN-gamma up-regulated TLR2/1 induction of 25-hydroxyvitamin D-1alpha-hydroxylase (i.e., CYP27B1), leading to enhanced bioconversion of 25-hydroxyvitamin D(3) (25D(3)) to its active metabolite 1,25D(3). 25-hydroxyvitamin D 60-79 interferon gamma Homo sapiens 17-26 20826144-10 2010 Moreover, tanshinone IIA could decrease the levels of MMP-9, TNF-alpha, IL-1alpha, IL-2, IFN-gamma and reactive oxygen species in leukocytes. tanshinone 10-24 interferon gamma Homo sapiens 89-98 21126375-10 2010 Two commercial interferon-gamma release assays, QFT-G-IT and T-SPOT.TB have been developed. Terbium 68-70 interferon gamma Homo sapiens 15-31 21084836-1 2010 In response to IFN-gamma, the latent cytoplasmic STAT1 protein is tyrosine phosphorylated and translocates to the nucleus where it transactivates STAT1-responsive genes. Tyrosine 66-74 interferon gamma Homo sapiens 15-24 21084836-7 2010 Furthermore, IFN-gamma-STAT1 cyclin D1 reduction correlated with decreased amount of p-Rb Ser-795, cyclin E and increased amounts of the cell cycle inhibitors p27(Kip1) and p21(Cip1). Serine 90-93 interferon gamma Homo sapiens 13-22 20942806-10 2010 alpha-Galactosylceramide (alphaGalCer) stimulation of peripheral blood mononuclear cells or isolated NK T cell lines from both patients induced IFN-gamma, but no IL-4 and no response towards autologous tumour cells or lysates. alpha-galactosylceramide 0-24 interferon gamma Homo sapiens 144-153 20800087-6 2010 CGX treatment significantly decreased the lipid peroxidation and glutathione depletion in the liver tissue, and also lowered tissue levels of tumor necrotic factor-alpha and interferon-gamma. N4-cyclopropyl-5-ethyl-6-piperidin-1-yl-pyrimidine-2,4-diamine 0-3 interferon gamma Homo sapiens 174-190 20727953-0 2010 Sesquiterpene lactone trilobolide activates production of interferon-gamma and nitric oxide. sesquiterpene lactone trilobolide 0-33 interferon gamma Homo sapiens 58-74 20727953-2 2010 We have found that upon the in vitro exposure to TB, rodent peritoneal cells and human peripheral blood mononuclear cells secrete high amounts of IFN-gamma. trilobolide 49-51 interferon gamma Homo sapiens 146-155 20849904-5 2010 In patients, LL-37 levels correlated with interferon (IFN)-gamma and IL-10 levels. Cathelicidin 13-18 interferon gamma Homo sapiens 42-64 20875052-3 2010 In this study, the impact of IFN-gamma treatment on phorbol-12-myristate-13-acetate-differentiated THP-1 cells infected with Mycobacterium bovis was investigated. Tetradecanoylphorbol Acetate 52-83 interferon gamma Homo sapiens 29-38 20849904-8 2010 LL-37 enhanced IFN-gamma, IL-4, IL-13, and TNF-alpha secretion from CD3/CD28-stimulated T cells, suppressed TNF-alpha, IL-1beta, IL-6, and IL-10 secretion from lipopolysaccharide-stimulated monocytes, and IL-17, IL-22, IL-1beta, IL-6, and IL-10 secretion from CD3/CD28-stimulated T cells. Cathelicidin 0-5 interferon gamma Homo sapiens 15-24 21102458-4 2010 Stimulation of antigen-presenting cells (APCs) with ATP led to increased expression of CD80 and CD86 in vitro and in vivo and actuated a cascade of proinflammatory events, including signal transducer and activator of transcription-1 (STAT1) phosphorylation, interferon-gamma (IFN-gamma) production and donor T cell expansion, whereas regulatory T cell numbers were reduced. Adenosine Triphosphate 52-55 interferon gamma Homo sapiens 258-274 20732368-0 2010 Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-gamma and/or tumor necrosis factor-alpha in healthy adults. Hexoses 18-24 interferon gamma Homo sapiens 93-109 21039520-6 2010 Both OGD-ACM and H(2) O(2) -ACM inhibited STAT nuclear signaling, as evidenced by a reduction in both STAT-1/3 binding to the IFN-gamma-activated site and IFN-gamma-activated site promoter activity. Hydrogen Peroxide 17-26 interferon gamma Homo sapiens 126-135 21039520-6 2010 Both OGD-ACM and H(2) O(2) -ACM inhibited STAT nuclear signaling, as evidenced by a reduction in both STAT-1/3 binding to the IFN-gamma-activated site and IFN-gamma-activated site promoter activity. Hydrogen Peroxide 17-26 interferon gamma Homo sapiens 155-164 21275454-3 2010 Interferon-gamma release assays (QuantiFERON -TB Gold In-Tube [QFT] and T-SPOT.TB ) are new alternatives to the TST to diagnose latent TB infection (LTBI) and active TB, and offer higher specificity and no cross-reactivity with Bacillus Calmette-Guerin (BCG) vaccine. tb gold 46-53 interferon gamma Homo sapiens 0-16 21102458-4 2010 Stimulation of antigen-presenting cells (APCs) with ATP led to increased expression of CD80 and CD86 in vitro and in vivo and actuated a cascade of proinflammatory events, including signal transducer and activator of transcription-1 (STAT1) phosphorylation, interferon-gamma (IFN-gamma) production and donor T cell expansion, whereas regulatory T cell numbers were reduced. Adenosine Triphosphate 52-55 interferon gamma Homo sapiens 276-285 21151477-4 2010 Control microglia were not tumoricidal against a number of murine and human tumor cells, whereas lipopolysaccharide/interferon-gamma-activated microglia lysed murine and human tumor cells by release of nitric oxide. Nitric Oxide 202-214 interferon gamma Homo sapiens 116-132 21142447-11 2010 Higher IFN-gamma levels (>5 pg/mL) were also observed in 2 of 7 asymptomatic patients, and 2 of 11 patients who underwent ART for 1 year or longer. art 125-128 interferon gamma Homo sapiens 7-16 20936910-3 2010 Follow-up interferon-gamma levels measured after 3 months of isoniazid and rifampicin treatment showed considerable variation. Isoniazid 61-70 interferon gamma Homo sapiens 10-26 20709103-3 2010 Here we show that, in human malignant T cells, the expression of a mutated IFN-gammaR2 chain in which the LI(255-256) internalization motif is replaced by two alanines (LI(255-256)AA) induces cell surface accumulation of the receptor and reinstates the cell sensitivity to IFN-gamma. Alanine 159-167 interferon gamma Homo sapiens 75-84 20709105-5 2010 Intranasally administered DBF and the mixture of virus+DBF induced an elevated expression of IFN-gamma, IL-6 and IL-10 cytokines, type I interferons, iNOS, and pDC markers in NALT. Dibenzofurans 26-29 interferon gamma Homo sapiens 93-102 20693747-2 2010 Neopterin, a by-product of the guanosine triphosphate pathway, is produced by activated macrophages on stimulation with interferon-gamma released from T lymphocytes, and is an activation marker for monocytes/macrophages. Neopterin 0-9 interferon gamma Homo sapiens 120-136 20693747-2 2010 Neopterin, a by-product of the guanosine triphosphate pathway, is produced by activated macrophages on stimulation with interferon-gamma released from T lymphocytes, and is an activation marker for monocytes/macrophages. Guanosine Triphosphate 31-53 interferon gamma Homo sapiens 120-136 20974954-7 2010 This study shows that IFN-gamma effector functions on intracellular C. trachomatis depend on the environmental oxygen supply, which could explain inadequate bacterial clearance and subsequent chronic infections eventually occurring in the UGT of women. Oxygen 111-117 interferon gamma Homo sapiens 22-31 20557297-9 2010 In contrast, Api g 1-primed DCs from BP allergics significantly enhanced the production of the Th1 cytokine IFN-gamma and significantly down-regulated IL-13 compared to maturation factors. Benzo(a)pyrene 37-39 interferon gamma Homo sapiens 108-117 20582413-7 2010 The potent immunostimulatory activity of zoledronate-treated DCs was associated with higher amount of isopentenyl pyrophosphate (IPP) in the culture and was correlated with better ability to activate Vgamma9Vdelta2 T cells as measured by IFN-gamma production. Zoledronic Acid 41-52 interferon gamma Homo sapiens 238-247 21116791-11 2010 Furthermore, Carbon monoxide, but not other end products of HO-1 activity, also suppressed IFN-gamma and TNF-alpha-induced TARC/CCL17 and MDC/CCL22 production. Carbon Monoxide 13-28 interferon gamma Homo sapiens 91-100 20670615-1 2010 The P2X7 receptor is an extracellular ATP-gated cation channel critical in inflammation and immunity, and can be up-regulated by IFN-gamma and LPS. Adenosine Triphosphate 38-41 interferon gamma Homo sapiens 129-138 20670615-8 2010 Co-incubation of cells with TGF-beta1 plus IFN-gamma and LPS prevented the up-regulation of P2X7 expression and ATP-induced ethidium(+) uptake in a concentration-dependent fashion with a maximum effect at 5ng/ml and with an IC(50) of ~0.4ng/ml. Adenosine Triphosphate 112-115 interferon gamma Homo sapiens 43-52 20670615-8 2010 Co-incubation of cells with TGF-beta1 plus IFN-gamma and LPS prevented the up-regulation of P2X7 expression and ATP-induced ethidium(+) uptake in a concentration-dependent fashion with a maximum effect at 5ng/ml and with an IC(50) of ~0.4ng/ml. Ethidium 124-132 interferon gamma Homo sapiens 43-52 20804502-0 2010 A set of genes associated with the interferon-gamma response of lung cancer patients undergoing alpha-galactosylceramide-pulsed dendritic cell therapy. alpha-galactosylceramide 96-120 interferon gamma Homo sapiens 35-51 20825427-10 2010 Respectively, the production of IL-10 and IFN-gamma was inversely associated with prostaglandin induction before birth. Prostaglandins 82-95 interferon gamma Homo sapiens 42-51 20655893-5 2010 IFN-gamma also correlated with DAS-CRP: 0.309(0.039) and SDAI: 0.301(0.044). sdai 57-61 interferon gamma Homo sapiens 0-9 20825427-12 2010 The production of IL-10 and IFN-gamma was also inversely associated with prostaglandin labour induction before birth. Prostaglandins 73-86 interferon gamma Homo sapiens 28-37 20814891-8 2010 Cell apoptosis after cisplatin treatment was evaluated by Annexin V staining, which showed that MPE cancer cells with higher pStat1 changes after IFN-gamma stimulation were more resistant to cisplatin. Cisplatin 21-30 interferon gamma Homo sapiens 146-155 20959405-0 2010 The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia. Imatinib Mesylate 77-85 interferon gamma Homo sapiens 4-8 20959405-0 2010 The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia. Imatinib Mesylate 77-85 interferon gamma Homo sapiens 10-19 20959405-1 2010 PURPOSE: The present study analyzed treatment outcomes of imatinib therapy by interindividual genetic variants in candidate biological pathways of chronic myeloid leukemia (CML) such as apoptosis, angiogenesis, IFN-gamma signaling pathways, or drug transport/metabolism of imatinib. Imatinib Mesylate 58-66 interferon gamma Homo sapiens 211-220 20959405-5 2010 CONCLUSIONS: The IFNG genotype was predictive for response to imatinib therapy, suggesting potential involvement of the IFN-gamma signaling pathway in the mechanism of action of imatinib in CML. Imatinib Mesylate 62-70 interferon gamma Homo sapiens 17-21 20959405-5 2010 CONCLUSIONS: The IFNG genotype was predictive for response to imatinib therapy, suggesting potential involvement of the IFN-gamma signaling pathway in the mechanism of action of imatinib in CML. Imatinib Mesylate 62-70 interferon gamma Homo sapiens 120-129 20959405-5 2010 CONCLUSIONS: The IFNG genotype was predictive for response to imatinib therapy, suggesting potential involvement of the IFN-gamma signaling pathway in the mechanism of action of imatinib in CML. Imatinib Mesylate 178-186 interferon gamma Homo sapiens 17-21 20959405-5 2010 CONCLUSIONS: The IFNG genotype was predictive for response to imatinib therapy, suggesting potential involvement of the IFN-gamma signaling pathway in the mechanism of action of imatinib in CML. Imatinib Mesylate 178-186 interferon gamma Homo sapiens 120-129 20815659-1 2010 The inflammatory cytokines tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) stimulate production of the inflammatory mediators prostaglandin E2 (PGEgamma), prostacyclin (PGIgamma), and nitric oxide (NO) in cultured lung epithelial cells. Dinoprostone 149-165 interferon gamma Homo sapiens 70-97 20815659-1 2010 The inflammatory cytokines tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) stimulate production of the inflammatory mediators prostaglandin E2 (PGEgamma), prostacyclin (PGIgamma), and nitric oxide (NO) in cultured lung epithelial cells. pgegamma 167-175 interferon gamma Homo sapiens 70-97 20815659-1 2010 The inflammatory cytokines tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) stimulate production of the inflammatory mediators prostaglandin E2 (PGEgamma), prostacyclin (PGIgamma), and nitric oxide (NO) in cultured lung epithelial cells. Epoprostenol 178-190 interferon gamma Homo sapiens 70-97 20815659-1 2010 The inflammatory cytokines tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) stimulate production of the inflammatory mediators prostaglandin E2 (PGEgamma), prostacyclin (PGIgamma), and nitric oxide (NO) in cultured lung epithelial cells. pgigamma 192-200 interferon gamma Homo sapiens 70-97 20815659-1 2010 The inflammatory cytokines tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) stimulate production of the inflammatory mediators prostaglandin E2 (PGEgamma), prostacyclin (PGIgamma), and nitric oxide (NO) in cultured lung epithelial cells. Nitric Oxide 207-219 interferon gamma Homo sapiens 70-97 20815659-3 2010 Primary bronchiolar epithelial Clara cells treated with TNFalpha and IFNgamma also produced increased PGE2, PGI2, and NO, and PG and NO production was decreased by MEK inhibition. Dinoprostone 102-106 interferon gamma Homo sapiens 69-77 20815659-3 2010 Primary bronchiolar epithelial Clara cells treated with TNFalpha and IFNgamma also produced increased PGE2, PGI2, and NO, and PG and NO production was decreased by MEK inhibition. Epoprostenol 108-112 interferon gamma Homo sapiens 69-77 20815659-3 2010 Primary bronchiolar epithelial Clara cells treated with TNFalpha and IFNgamma also produced increased PGE2, PGI2, and NO, and PG and NO production was decreased by MEK inhibition. Prostaglandins 102-104 interferon gamma Homo sapiens 69-77 20814891-8 2010 Cell apoptosis after cisplatin treatment was evaluated by Annexin V staining, which showed that MPE cancer cells with higher pStat1 changes after IFN-gamma stimulation were more resistant to cisplatin. Cisplatin 191-200 interferon gamma Homo sapiens 146-155 20691806-3 2010 Sodium butyrate (NaB) has received much attention as a potential chemopreventive agent for cancer treatment due to its protective action against intracellular events including IFN-gamma-mediated signaling transduction. Butyric Acid 0-15 interferon gamma Homo sapiens 176-185 20691806-3 2010 Sodium butyrate (NaB) has received much attention as a potential chemopreventive agent for cancer treatment due to its protective action against intracellular events including IFN-gamma-mediated signaling transduction. nab 17-20 interferon gamma Homo sapiens 176-185 20386089-9 2010 The VDR agonist elocalcitol partially reverts COX-2 and IL-8 mRNA upregulation induced by a pro-inflammatory cytokine mixture (IL-17, interferon-gamma, tumor necrosis factor-alpha) and inhibits cell migration in urethral cells. BXL628 16-27 interferon gamma Homo sapiens 134-179 20817120-6 2010 Allogeneic CD4(+)T cells in co-culture with loxoribine-treated MoDCs proliferated more strongly, at lower DC/CD4(+)T-cell ratio (1:80), and secreted significantly higher levels of IL-17 and IFN-gamma compared to the cultures with control MoDCs. loxoribine 44-54 interferon gamma Homo sapiens 190-199 20697326-0 2010 CP-690550, a Janus kinase inhibitor, suppresses CD4+ T-cell-mediated acute graft-versus-host disease by inhibiting the interferon-gamma pathway. tofacitinib 0-9 interferon gamma Homo sapiens 119-135 20697326-8 2010 An analysis of the initial donor-derived CD4 T-cell responses revealed that the inhibitory effects of CP-690550 were largely related to the suppression of donor CD4 T-cell-mediated interferon (IFN)-gamma production. tofacitinib 102-111 interferon gamma Homo sapiens 181-203 20697326-10 2010 Because lethality was considerably delayed by the systemic blockade of IFN-gamma, the principal protective effect of CP-690550 occurred through the modulation of IFN-gamma production. tofacitinib 117-126 interferon gamma Homo sapiens 71-80 20697326-10 2010 Because lethality was considerably delayed by the systemic blockade of IFN-gamma, the principal protective effect of CP-690550 occurred through the modulation of IFN-gamma production. tofacitinib 117-126 interferon gamma Homo sapiens 162-171 20521304-6 2010 As the fed-batch culture progressed, there was also an increase in less sialylated IFN-gamma glycoforms, leading to a 30% decrease in the molar ratio of sialic acid to recombinant IFN-gamma. N-Acetylneuraminic Acid 153-164 interferon gamma Homo sapiens 83-92 20815336-2 2010 A DNA hairpin containing IFN-gamma-binding aptamer was thiolated, conjugated with methylene blue (MB) redox tag, and immobilized on a gold electrode by self-assembly. Methylene Blue 82-96 interferon gamma Homo sapiens 25-34 20967288-4 2010 Stimulation of either CD4(+) T cells or CD8(+) T cells of HCL volunteers with SLA induced a significantly (P<0.05) higher IFN-gamma production compared with the cells of controls. Hydrochloric Acid 58-61 interferon gamma Homo sapiens 125-134 20967288-5 2010 Upregulation of IFN-gamma gene expression in CD4(+) cells (P<0.001) and CD8(+) cells (P = 0.006) of HCL volunteers was significantly more than that of controls. Hydrochloric Acid 103-106 interferon gamma Homo sapiens 16-25 20967288-7 2010 In HCL volunteers a significantly (P = 0.014) higher number of CD4(+) cells were positive for intracellular IFN-gamma production than CD8(+) cells. Hydrochloric Acid 3-6 interferon gamma Homo sapiens 108-117 19880819-13 2010 Tacrolimus AER was superior to TAC MED at preventing AE IFN-gamma, IL-10, IL-13, monocyte chemoattractant protein-1 chemokine (C-C motif) ligand 5 (RANTES) and TNF-alpha up-regulation. Tacrolimus 0-10 interferon gamma Homo sapiens 56-65 19901345-7 2010 Be-stimulated CBD BAL cell IFN-gamma and TNF-alpha cytokine production was decreased by treatment with sulfasalazine or mesalamine. Sulfasalazine 103-116 interferon gamma Homo sapiens 27-36 19901345-7 2010 Be-stimulated CBD BAL cell IFN-gamma and TNF-alpha cytokine production was decreased by treatment with sulfasalazine or mesalamine. Mesalamine 120-130 interferon gamma Homo sapiens 27-36 20815336-7 2010 Importantly, the same aptasensor could be regenerated by disrupting aptamer-IFN-gamma complex in urea buffer and reused multiple times. Urea 97-101 interferon gamma Homo sapiens 76-85 20931695-4 2010 Nevertheless, expression of molecules and PBTs was quantitatively specific: IFNG effects for rejection; T cell and macrophage transcripts for T cell-mediated rejection; endothelial and NK transcripts for antibody-mediated rejection. pbts 42-46 interferon gamma Homo sapiens 76-80 20506284-4 2010 Galactose (+/-uridine), glucosamine (+/-uridine), and N-acetylmannosamine (ManNAc) (+/-cytidine) feeding resulted in 12%, 28%, and 32% increase in IFN-gamma sialylation as compared to the untreated control cultures. Galactose 0-9 interferon gamma Homo sapiens 147-156 20506284-4 2010 Galactose (+/-uridine), glucosamine (+/-uridine), and N-acetylmannosamine (ManNAc) (+/-cytidine) feeding resulted in 12%, 28%, and 32% increase in IFN-gamma sialylation as compared to the untreated control cultures. N-acetylmannosamine 54-73 interferon gamma Homo sapiens 147-156 20506284-4 2010 Galactose (+/-uridine), glucosamine (+/-uridine), and N-acetylmannosamine (ManNAc) (+/-cytidine) feeding resulted in 12%, 28%, and 32% increase in IFN-gamma sialylation as compared to the untreated control cultures. Cytidine 84-95 interferon gamma Homo sapiens 147-156 20427344-7 2010 Stimulation of infiltrated TAMs with lipopolysaccharide (LPS)/interferon-gamma revealed a reduced expression of the pro-inflammatory markers interleukin (IL)-6, tumor necrosis factor-alpha and inducible nitric oxide synthase in HIF-1alpha(-/-) MFs. tams 27-31 interferon gamma Homo sapiens 62-78 20339378-1 2010 We have previously analysed the bioenergetic consequences of activating J774.A1 macrophages (MPhi) with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) and found that there is a nitric oxide (NO)-dependent mitochondrial impairment and stabilization of hypoxia-inducible factor (HIF)-1alpha, which synergize to activate glycolysis and generate large quantities of ATP. Nitric Oxide 188-200 interferon gamma Homo sapiens 104-120 21083751-8 2010 T-bet expression and IFN-gamma production increased, while STAT6 activation and IL-4 production decreased following therapy with celecoxib and celecoxib plus lansoprazole, respectively. Celecoxib 143-152 interferon gamma Homo sapiens 21-30 20339378-1 2010 We have previously analysed the bioenergetic consequences of activating J774.A1 macrophages (MPhi) with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) and found that there is a nitric oxide (NO)-dependent mitochondrial impairment and stabilization of hypoxia-inducible factor (HIF)-1alpha, which synergize to activate glycolysis and generate large quantities of ATP. Nitric Oxide 188-200 interferon gamma Homo sapiens 122-131 20339378-1 2010 We have previously analysed the bioenergetic consequences of activating J774.A1 macrophages (MPhi) with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) and found that there is a nitric oxide (NO)-dependent mitochondrial impairment and stabilization of hypoxia-inducible factor (HIF)-1alpha, which synergize to activate glycolysis and generate large quantities of ATP. Adenosine Triphosphate 373-376 interferon gamma Homo sapiens 122-131 20805415-0 2010 Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-gamma in a nitric oxide-dependent manner. Nitric Oxide 119-131 interferon gamma Homo sapiens 104-113 20668435-4 2010 The results of this study showed that DHA reduced expressions of tumor necrosis factor-alpha, interleukin-6, nitric oxide synthase, and cyclo-oxygenase-2, induced by interferon-gamma, and induced upregulation of heme oxygenase-1 (HO-1) in BV-2 microglia. Docosahexaenoic Acids 38-41 interferon gamma Homo sapiens 166-182 20564542-10 2010 Phytohemagglutinine (PHA)-stimulated PBMC from patients with hyaluronic implants presenting adverse effects showed a slight increase in the production of interferon (IFN)-gamma and higher expression of CD25, CD69, or CD71. phytohemagglutinine 0-19 interferon gamma Homo sapiens 154-176 20564542-10 2010 Phytohemagglutinine (PHA)-stimulated PBMC from patients with hyaluronic implants presenting adverse effects showed a slight increase in the production of interferon (IFN)-gamma and higher expression of CD25, CD69, or CD71. 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-hexanoylamine 21-24 interferon gamma Homo sapiens 154-176 20564542-10 2010 Phytohemagglutinine (PHA)-stimulated PBMC from patients with hyaluronic implants presenting adverse effects showed a slight increase in the production of interferon (IFN)-gamma and higher expression of CD25, CD69, or CD71. hyaluronic 61-71 interferon gamma Homo sapiens 154-176 20699227-6 2010 Sunitinib administration led to an early downmodulation of IFNgamma levels as well as reduction of IFNgamma receptor and downstream angiostatic chemokines CXCL9 to 11 within the tumor. Sunitinib 0-9 interferon gamma Homo sapiens 59-67 20699227-6 2010 Sunitinib administration led to an early downmodulation of IFNgamma levels as well as reduction of IFNgamma receptor and downstream angiostatic chemokines CXCL9 to 11 within the tumor. Sunitinib 0-9 interferon gamma Homo sapiens 99-107 20799759-7 2010 As a phosphodiesterase inhibitor, pentoxifylline downregulates pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-6, and interferon-gamma. Pentoxifylline 34-48 interferon gamma Homo sapiens 146-162 20709516-6 2010 NAA and AA patients showed higher IFN-gamma and EDN levels compared to AC and NC, with no differences in IL-4, IL-5, or IL-13 levels among the four groups. 1-naphthaleneacetic acid 0-3 interferon gamma Homo sapiens 34-43 20883321-4 2010 IFN-gamma +874 genotype AA was significantly higher in patients with TB than that in control (Pc=0.015), in extrapulmonary than patients with pulmonary TB (PTB) (Pc=0.009), and young children with TB below 5 years (Pc=0.024). Terbium 69-71 interferon gamma Homo sapiens 0-9 20883321-4 2010 IFN-gamma +874 genotype AA was significantly higher in patients with TB than that in control (Pc=0.015), in extrapulmonary than patients with pulmonary TB (PTB) (Pc=0.009), and young children with TB below 5 years (Pc=0.024). Terbium 152-154 interferon gamma Homo sapiens 0-9 20883321-4 2010 IFN-gamma +874 genotype AA was significantly higher in patients with TB than that in control (Pc=0.015), in extrapulmonary than patients with pulmonary TB (PTB) (Pc=0.009), and young children with TB below 5 years (Pc=0.024). Terbium 152-154 interferon gamma Homo sapiens 0-9 20616203-5 2010 The cytokine upregulation was observed in vitro at methanol concentrations as low as 0.08% (25mM) as measured by interleukin-2, interferon-gamma, and tumor necrosis factor-alpha release in T cells. Methanol 51-59 interferon gamma Homo sapiens 128-177 20631061-6 2010 Accordingly, DNBS- but not DNCB-modified human immature dendritic cells (iDC) induced in vitro primary human T-cell responses as did 2,4,6-trinitrobenzenesulfonic acid-modified iDC as measured by dinitrophenyl (DNP)- and trinitrophenyl (TNP)-specific T-cell proliferation and interferon gamma (IFN-gamma) production in CD4(+) and CD8(+) T-cell subsets. 2,4-dinitrobenzenesulfonic acid 13-17 interferon gamma Homo sapiens 276-303 20654672-0 2010 Inhibitory effects of SSRIs on IFN-gamma induced microglial activation through the regulation of intracellular calcium. Calcium 111-118 interferon gamma Homo sapiens 31-40 20654672-6 2010 Our results showed that the selective serotonin reuptake inhibitors (SSRIs) paroxetine and sertraline significantly inhibited the generation of NO and tumor necrosis factor (TNF)-alpha from interferon (IFN)-gamma-activated 6-3 microglia. Paroxetine 76-86 interferon gamma Homo sapiens 190-212 20654672-6 2010 Our results showed that the selective serotonin reuptake inhibitors (SSRIs) paroxetine and sertraline significantly inhibited the generation of NO and tumor necrosis factor (TNF)-alpha from interferon (IFN)-gamma-activated 6-3 microglia. Sertraline 91-101 interferon gamma Homo sapiens 190-212 20654672-8 2010 Our results suggest that paroxetine and sertraline may inhibit microglial activation through inhibition of IFN-gamma-induced elevation of intracellular Ca(2+). Paroxetine 25-35 interferon gamma Homo sapiens 107-116 20654672-8 2010 Our results suggest that paroxetine and sertraline may inhibit microglial activation through inhibition of IFN-gamma-induced elevation of intracellular Ca(2+). Sertraline 40-50 interferon gamma Homo sapiens 107-116 21129263-5 2010 After treating with CsA for 6 months of CsA treatment, expression of T-bet, STAT4, T-bet/GATA-3 ratio, Th1 proportion, IFN-gamma and IL-12 levels were lower than before, however, the expression of T-bet, STAT4, T-bet/GATA-3 ratio, Th1 proportion and IFN-gamma had not been reduced to normal state. Cyclosporine 20-23 interferon gamma Homo sapiens 119-128 21129263-8 2010 CsA lowers the abnormal activation of IFN-gamma/T-bet and IL-12/STAT4 pathways to correct Th1 hyperpolarization, which may reduce the abnormally activated cell-mediated immunity and relax hematopoietic depression of AA patients. Cyclosporine 0-3 interferon gamma Homo sapiens 38-47 21129263-5 2010 After treating with CsA for 6 months of CsA treatment, expression of T-bet, STAT4, T-bet/GATA-3 ratio, Th1 proportion, IFN-gamma and IL-12 levels were lower than before, however, the expression of T-bet, STAT4, T-bet/GATA-3 ratio, Th1 proportion and IFN-gamma had not been reduced to normal state. Cyclosporine 20-23 interferon gamma Homo sapiens 250-259 20949125-4 2010 An engineered STAT1-CC molecule with double cysteine substitutions in the Src-homology 2 (SH2) domains of STAT1 (at Ala-656 and Asn-658) efficiently phosphorylates and translocates to the nucleus of IFN-resistant cells in an IFN-gamma dependent manner. Cysteine 44-52 interferon gamma Homo sapiens 225-234 20949125-4 2010 An engineered STAT1-CC molecule with double cysteine substitutions in the Src-homology 2 (SH2) domains of STAT1 (at Ala-656 and Asn-658) efficiently phosphorylates and translocates to the nucleus of IFN-resistant cells in an IFN-gamma dependent manner. Alanine 116-119 interferon gamma Homo sapiens 225-234 20949125-4 2010 An engineered STAT1-CC molecule with double cysteine substitutions in the Src-homology 2 (SH2) domains of STAT1 (at Ala-656 and Asn-658) efficiently phosphorylates and translocates to the nucleus of IFN-resistant cells in an IFN-gamma dependent manner. Asparagine 128-131 interferon gamma Homo sapiens 225-234 20854672-9 2010 Interestingly, in addition to these cells, we found CsA-resistant IFN-gamma producing T cells (CD4+T = 26.9 +- 3.6% and CD8+T = 20.3 +- 2.1%) implying the existence of activated bystander T cells in response to dengue antigen in vitro. Cyclosporine 52-55 interferon gamma Homo sapiens 66-75 20599915-0 2010 Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4+ naive T cells. ursolic acid 0-12 interferon gamma Homo sapiens 132-141 20833730-4 2010 We report that TNFalpha activates the classical NF-kappaB (nuclear factor kappaB) pathway, whereas IFNgamma activates JAK2/STAT-1alpha and that inhibition of the JAK/STAT pathway is more effective in abrogating CXCL10 release than the steroid fluticasone. Steroids 235-242 interferon gamma Homo sapiens 99-107 20833730-3 2010 IFNgamma and TNFalpha synergistically induce CXCL10 release from human ASM cells in a steroid-insensitive manner, via an as yet undefined mechanism. Steroids 86-93 interferon gamma Homo sapiens 0-8 20833730-4 2010 We report that TNFalpha activates the classical NF-kappaB (nuclear factor kappaB) pathway, whereas IFNgamma activates JAK2/STAT-1alpha and that inhibition of the JAK/STAT pathway is more effective in abrogating CXCL10 release than the steroid fluticasone. Fluticasone 243-254 interferon gamma Homo sapiens 99-107 20833730-8 2010 Our results provide evidence that synergism between TNFalpha and IFNgamma lies at the level of coactivator recruitment in human ASM and suggest that inhibition of JAK/STAT signaling may be of therapeutic benefit in steroid-resistant airway disease. Steroids 215-222 interferon gamma Homo sapiens 65-73 20643137-1 2010 Interferon-gamma stimulation triggers tyrosine phosphorylation of the transcription factor STAT1 at position 701, which is associated with switching from carrier-independent nucleocytoplasmic shuttling to carrier-mediated nuclear import. Tyrosine 38-46 interferon gamma Homo sapiens 0-16 20510203-10 2010 Furthermore, SPI-112Me enhanced interferon-gamma (IFN-gamma)-stimulated STAT1 tyrosine phosphorylation, ISRE-luciferase reporter activity, p21 expression, and the anti-proliferative effect. Tyrosine 78-86 interferon gamma Homo sapiens 32-48 20510203-10 2010 Furthermore, SPI-112Me enhanced interferon-gamma (IFN-gamma)-stimulated STAT1 tyrosine phosphorylation, ISRE-luciferase reporter activity, p21 expression, and the anti-proliferative effect. Tyrosine 78-86 interferon gamma Homo sapiens 50-59 20691158-1 2010 Neopterin production is induced in human monocyte-derived macrophages and dendritic cells upon stimulation with Th1-type cytokine interferon-gamma (IFN-gamma). Neopterin 0-9 interferon gamma Homo sapiens 148-157 20691158-2 2010 In parallel, IFN-gamma induces the tryptophan-(trp)-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and triggers the formation of reactive oxygen species (ROS). Tryptophan 35-45 interferon gamma Homo sapiens 13-22 20691158-2 2010 In parallel, IFN-gamma induces the tryptophan-(trp)-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and triggers the formation of reactive oxygen species (ROS). Tryptophan 47-50 interferon gamma Homo sapiens 13-22 20691158-2 2010 In parallel, IFN-gamma induces the tryptophan-(trp)-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and triggers the formation of reactive oxygen species (ROS). Reactive Oxygen Species 133-156 interferon gamma Homo sapiens 13-22 20691158-2 2010 In parallel, IFN-gamma induces the tryptophan-(trp)-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and triggers the formation of reactive oxygen species (ROS). Reactive Oxygen Species 158-161 interferon gamma Homo sapiens 13-22 20580568-8 2010 IFN-gamma enhanced rapid intracellular killing of MRSA in the presence of triple-drug treatment or Dap alone. Daptomycin 99-102 interferon gamma Homo sapiens 0-9 20511543-3 2010 Here, we show that IFNgamma induces normal levels of kynurenine in cultures of O(2)( )-deficient monocytes, dendritic cells, and polymorphonuclear leukocytes from gp91(PHOX)- or p47(PHOX)-deficient human CGD donors. Kynurenine 53-63 interferon gamma Homo sapiens 19-27 20511543-3 2010 Here, we show that IFNgamma induces normal levels of kynurenine in cultures of O(2)( )-deficient monocytes, dendritic cells, and polymorphonuclear leukocytes from gp91(PHOX)- or p47(PHOX)-deficient human CGD donors. Superoxides 79-86 interferon gamma Homo sapiens 19-27 20626741-6 2010 Also, the serum levels of IL-2 and gamma-interferon (IFN-gamma) were increased in cITP patients (P < 10(-3) and P = 0 04 respectively) and blood donors (P < 10(-3) and P = 0 03 respectively) harbouring the IL2-330G allele. citp 82-86 interferon gamma Homo sapiens 53-62 20580568-0 2010 IFN-gamma enhances killing of methicillin-resistant Staphylococcus aureus by human monocytes more effectively than GM-CSF in the presence of daptomycin and other antibiotics. Daptomycin 141-151 interferon gamma Homo sapiens 0-9 20580568-1 2010 Because cytokines have been utilized in treatment of sepsis in neonates, we studied the effects of interferon-gamma (IFN-gamma) and GM-CSF on killing of intracellular methicilin-resistant Staphylococcus aureus (MRSA) by human monocyte derived macrophages (MDM) in the presence of daptomycin (Dap), rifampin (Rif), gentamicin (Gen), and combinations of these drugs. methicilin 167-177 interferon gamma Homo sapiens 117-126 20706985-3 2010 We found that the high affinity and stable AHR-ligand dioxin as well as the natural AHR-ligand 6-formylinolo[3,2-b] carbazole induced the downstream AHR-target cytochrome P450A1, and without affecting IFN-gamma, they enhanced IL-22 while simultaneously decreasing IL-17A production by CD4(+) T cells. Dioxins 54-60 interferon gamma Homo sapiens 201-210 20500129-5 2010 On the other hand, Montanide and microparticles given subcutaneously resulted in effective adjuvants and revealed mixed Th1/Th2 immune responses, with moderate antibody and lymphoproliferative responses, and higher IFN-gamma secretion for Montanide. montanide 19-28 interferon gamma Homo sapiens 215-224 20537761-3 2010 Here, we demonstrated that PPARgamma is necessary for TZD to interfere with TNFalpha and IFNgamma inflammatory activity in human endothelial cells. tzd 54-57 interferon gamma Homo sapiens 89-97 20676966-4 2010 The results showed that lycopene and simvastatin applied together reduced TNFalpha and IFNgamma secretion, and abolished the increased production of the proinflammatory cytokine IL-1gamma caused by incubation with simvastatin only, an observation suggesting that simultaneous administration of both substances may reduce inflammatory responses. Lycopene 24-32 interferon gamma Homo sapiens 87-95 20676966-4 2010 The results showed that lycopene and simvastatin applied together reduced TNFalpha and IFNgamma secretion, and abolished the increased production of the proinflammatory cytokine IL-1gamma caused by incubation with simvastatin only, an observation suggesting that simultaneous administration of both substances may reduce inflammatory responses. Simvastatin 37-48 interferon gamma Homo sapiens 87-95 20435158-3 2010 The present study was designed to investigate the role of IDO and kynurenines in the IFN-gamma-mediated apoptosis of lens epithelial cells and to determine the signaling pathways involved. Kynurenine 66-77 interferon gamma Homo sapiens 85-94 20435158-0 2010 Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: apoptosis through the formation of 3-hydroxykynurenine. 3-hydroxykynurenine 128-147 interferon gamma Homo sapiens 44-60 20435158-5 2010 Meanwhile, fludarabine, an inhibitor of STAT1 activation, blocked IFN-gamma-mediated IDO expression. fludarabine 11-22 interferon gamma Homo sapiens 66-75 20435158-2 2010 IFN-gamma induces the expression of indoleamine 2,3-dioxygenase (IDO) and thereby enhances the production of kynurenines from l-tryptophan. Kynurenine 109-120 interferon gamma Homo sapiens 0-9 20435158-9 2010 The induction of IDO by IFN-gamma in HLE-B3 cells caused increases in intracellular ROS, cytosolic cytochrome c and caspase-3 activity, along with a decrease in protein-free thiol content. ros 84-87 interferon gamma Homo sapiens 24-33 20435158-2 2010 IFN-gamma induces the expression of indoleamine 2,3-dioxygenase (IDO) and thereby enhances the production of kynurenines from l-tryptophan. Tryptophan 126-138 interferon gamma Homo sapiens 0-9 20435158-9 2010 The induction of IDO by IFN-gamma in HLE-B3 cells caused increases in intracellular ROS, cytosolic cytochrome c and caspase-3 activity, along with a decrease in protein-free thiol content. Sulfhydryl Compounds 174-179 interferon gamma Homo sapiens 24-33 20435158-12 2010 MT and a kynurenine 3-hydroxylase inhibitor (Ro61-8048) effectively inhibited IFN-gamma-mediated apoptosis in HLE-B3 cells. Ro 61-8048 45-54 interferon gamma Homo sapiens 78-87 20675591-3 2010 In this study, we demonstrate that the IFN-gamma-mediated phosphorylation of STAT1 on Ser(727), crucial for its maximal activity, was attenuated in human macrophages by pharmacological inhibition of ERK. Serine 86-89 interferon gamma Homo sapiens 39-48 20626296-0 2010 Involvement of interferon-gamma in bowel disease pathogenesis by nitric oxide pathway: a study in Algerian patients. Nitric Oxide 65-77 interferon gamma Homo sapiens 15-31 20675591-7 2010 These studies suggest a critical role for ERK signaling in the IFN-gamma-mediated changes in macrophage cholesterol homeostasis and gene expression during atherosclerosis. Cholesterol 104-115 interferon gamma Homo sapiens 63-72 20424892-0 2010 Novel 1-alkyl-tryptophan derivatives downregulate IDO1 and IDO2 mRNA expression induced by interferon-gamma in dendritic cells. 1-alkyl-tryptophan 6-24 interferon gamma Homo sapiens 91-107 20386869-8 2010 TNF production in LPS/IFNgamma-activated monocytes was readily downregulated by dexamethasone and, to some extent, by chloroquine and etanercept. Dexamethasone 80-93 interferon gamma Homo sapiens 22-30 20386869-8 2010 TNF production in LPS/IFNgamma-activated monocytes was readily downregulated by dexamethasone and, to some extent, by chloroquine and etanercept. Chloroquine 118-129 interferon gamma Homo sapiens 22-30 20824205-8 2010 Early TB lesions were characterized by a highly pro-inflammatory environment, expressing high levels of immune signaling pathways involving IFNgamma, TNFalpha, JAK, STAT and C-C/C-X-C chemokines. Terbium 6-8 interferon gamma Homo sapiens 140-148 20363329-0 2010 Purification and refolding of recombinant human interferon-gamma in urea-ammonium chloride solution. Urea 68-72 interferon gamma Homo sapiens 48-64 20363329-0 2010 Purification and refolding of recombinant human interferon-gamma in urea-ammonium chloride solution. Ammonium Chloride 73-90 interferon gamma Homo sapiens 48-64 20727206-1 2010 BACKGROUND: Neopterin is produced by human macrophages/monocytes when stimulated with interferon-gamma. Neopterin 12-21 interferon gamma Homo sapiens 86-102 20639488-5 2010 Poly(I:C) but not polyadenylic-polyuridylic acid synergized with mDC-derived IL-12 for IFN-gamma production by acting directly on NK cells. Poly I-C 0-8 interferon gamma Homo sapiens 87-96 20709290-2 2010 In this issue of Cell Host & Microbe, Saha and colleagues report that mammalian PGRPs can prevent aberrant interferon-gamma--induced inflammatory damage in vivo by modulating the composition of the intestinal bacterial flora. Adenosine Monophosphate 28-31 interferon gamma Homo sapiens 111-127 20591421-3 2010 Ester analogues 30a, 31a, and 61 showed activity for IFNgamma and IL-4 production of iNKT cells, while ether (31b) and 4-methoxy ester (76) analogues of alpha-galactosylceramide were not active for iNKT cells. Esters 0-5 interferon gamma Homo sapiens 53-61 20623541-1 2010 Cytosolic phospholipase A(2)-inhibited astrocytes respond to the cocktail lipopolysaccharide/interferon-gamma with an immediate formation of peroxynitrite (ONOO(-)) and a delayed lethal response. Peroxynitrous Acid 141-154 interferon gamma Homo sapiens 93-109 20623541-1 2010 Cytosolic phospholipase A(2)-inhibited astrocytes respond to the cocktail lipopolysaccharide/interferon-gamma with an immediate formation of peroxynitrite (ONOO(-)) and a delayed lethal response. onoo 156-160 interferon gamma Homo sapiens 93-109 19874329-8 2010 In the suppression group, serum IFN-gamma and TNF-alpha levels were increased after treatment with levothyroxine compared with baseline values and there was a borderline statistical significance (P = 0.05 for both). Thyroxine 99-112 interferon gamma Homo sapiens 32-41 20463188-7 2010 Primary salivary epithelial cells in vitro from pSS produced MCP-1, which was significantly stimulated by IFN-gamma, as identified by both ELISA and RT-PCR. pss 48-51 interferon gamma Homo sapiens 106-115 20666952-1 2010 AIM: To investigate whether the interferon-gamma (IFNG) gene dinucleotide (CA)-repeat polymorphism is responsible in part for genetic susceptibility to endometriosis in South Indian women. Dinucleoside Phosphates 61-73 interferon gamma Homo sapiens 32-48 20666952-1 2010 AIM: To investigate whether the interferon-gamma (IFNG) gene dinucleotide (CA)-repeat polymorphism is responsible in part for genetic susceptibility to endometriosis in South Indian women. Dinucleoside Phosphates 61-73 interferon gamma Homo sapiens 50-54 20541808-5 2010 DXS prevented the up-regulation of NK cell activation markers triggered by TLR2 ligands or supernatants of TLR4-activated MoDC and dose-dependently abrogated NK cell degranulation and IFN-gamma secretion. Dextran Sulfate 0-3 interferon gamma Homo sapiens 184-193 20381618-6 2010 Additionally, chronic treatment with rimonabant produced decreases in frontal cortex serotonin levels, marked reductions in hippocampal cell proliferation, survival, and BDNF levels, and elevations in the concentrations of pro-inflammatory cytokines including interferon gamma and TNF alpha. Rimonabant 37-47 interferon gamma Homo sapiens 260-290 20434477-15 2010 Using dexamethasone as an immunosuppressive drug for anti-inflammatory therapy, we found a significant reduction of GM-CSF, IL-1beta, and IFN-gamma. Dexamethasone 6-19 interferon gamma Homo sapiens 138-147 20599745-0 2010 Celastrol suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells. celastrol 0-9 interferon gamma Homo sapiens 21-30 21038650-7 2010 Amount of IFN-gamma increased, IL-4 reduced, and Tc1 cell raised after treatment, which led to the rise of Tcl/Tc2 ratio in both groups; while in the treated group, in addition to the above-mentioned changes, the Th1 cell was increased also, and thus to make elevation of Th1/Th2 ratio (P < 0.05). Triclosan 107-110 interferon gamma Homo sapiens 10-19 21038651-6 2010 Moreover, the CPS group showed a higher serum IL-4 (P < 0.05) but a lower IFN-gamma/IL-4 level as compared with those in the NP group (P < 0.01). cps 14-17 interferon gamma Homo sapiens 77-86 20599745-8 2010 These results suggest that celastrol may exert anti-inflammatory responses by suppressing IFN-gamma-induced expression of ICAM-1 and subsequent monocyte adhesion via expression of HO-1 in the keratinocytes. celastrol 27-36 interferon gamma Homo sapiens 90-99 20599745-2 2010 In this study, we examined the suppressive effect of celastrol on IFN-gamma-induced expression of ICAM-1 and the molecular mechanism responsible for these activities. celastrol 53-62 interferon gamma Homo sapiens 66-75 20599745-4 2010 Treatment of HaCaT cells with tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, reversed the suppressive effect of celastrol on IFN-gamma-induced protein and mRNA expression of ICAM-1. tin protoporphyrin IX 30-51 interferon gamma Homo sapiens 138-147 20599745-4 2010 Treatment of HaCaT cells with tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, reversed the suppressive effect of celastrol on IFN-gamma-induced protein and mRNA expression of ICAM-1. S-Nitroso-N-propionyl-D,L-penicillamine 53-57 interferon gamma Homo sapiens 138-147 20599745-4 2010 Treatment of HaCaT cells with tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, reversed the suppressive effect of celastrol on IFN-gamma-induced protein and mRNA expression of ICAM-1. celastrol 125-134 interferon gamma Homo sapiens 138-147 20599745-5 2010 HO-1 knockdown using small interfering RNA (siRNA) led to reverse inhibition of IFN-gamma-induced up-regulation of ICAM-1 by celastrol. celastrol 125-134 interferon gamma Homo sapiens 80-89 20599745-6 2010 In addition, SnPP reversed suppression of IFN-gamma-induced promoter activity of ICAM-1 by celastrol. celastrol 91-100 interferon gamma Homo sapiens 42-51 20599745-7 2010 Furthermore, blockage of HO-1 activity by SnPP and HO-1 siRNA reversed the inhibitory effect of celastrol on IFN-gamma-induced adhesion of monocytes to keratinocytes. celastrol 96-105 interferon gamma Homo sapiens 109-118 20562257-6 2010 IFN-gamma, a cytokine linked to atherosclerosis and graft arteriosclerosis, potentiated the inflammatory responses of intact arteries and cultured vascular smooth muscle cells (VSMCs) to polyinosinic:polycytidylic acid [poly(I:C)] and was necessary for inflammatory responses of VSMC to self-RNA derived from autologous cells. Poly C 200-218 interferon gamma Homo sapiens 0-9 20543105-5 2010 The increased apoptosis of Spi6 knock-out (KO) iNKT cells lead to a complete loss in the production of IL-4 and IFN-gamma by Spi6 KO iNKT cells after PBS-57 challenge. Lead 150-153 interferon gamma Homo sapiens 112-121 20417710-4 2010 We found that fenofibrate could dose-dependently inhibit cytokine production such as interleukin-2, interleukin-4, tumor necrosis factor-alpha and interferon-gamma from activated T cells. Fenofibrate 14-25 interferon gamma Homo sapiens 147-163 20724768-1 2010 AIM: to find out the the influence of iron on the levels of plasma IL-2 and IFNgamma in iron deficiency anemia patient. Iron 38-42 interferon gamma Homo sapiens 76-84 20724768-12 2010 CONCLUSION: concentration of IL2 dan IFNgamma in plasma significantly increased after administration of iron tablets for 8 weeks as compared to that before iron treatment. Iron 104-108 interferon gamma Homo sapiens 37-45 20724768-12 2010 CONCLUSION: concentration of IL2 dan IFNgamma in plasma significantly increased after administration of iron tablets for 8 weeks as compared to that before iron treatment. Iron 156-160 interferon gamma Homo sapiens 37-45 20507321-7 2010 Moreover, treating gastric cancer cells with DAC enhanced the suppressive effects of interferon-alpha, interferon-beta, and interferon-gamma on cell growth. Decitabine 45-48 interferon gamma Homo sapiens 124-140 20489149-6 2010 ROS production and OS were increased in IL-1alpha/IFNgamma-incubated thyrocytes and in destructive thyroiditis. Reactive Oxygen Species 0-3 interferon gamma Homo sapiens 50-58 20489149-7 2010 In vitro, NAC not only reduced ROS production below control levels, but further decreased the expression of thyroid-specific proteins in addition to IL-1alpha/IFNgamma-inhibitory effects. Acetylcysteine 10-13 interferon gamma Homo sapiens 159-167 20868571-13 2010 The IFN-gamma/IL-4 ratio (Th1/Th2) was inversely correlated with serum 25(OH)D levels (r=-0.599; p=0.0053). Deuterium 77-78 interferon gamma Homo sapiens 4-13 20795385-6 2010 There were substantial increase of IFN-gamma level and decrease of IgE level in serum in group I that could point to predominance of Thl-dependent immune response and activation of cellular immunity. Orlistat 133-136 interferon gamma Homo sapiens 35-44 20540705-4 2010 Activation of the ASMase/ceramide pathway is a shared response to an ever-growing list of receptor and non-receptor mediated forms of cellular stress including: death ligands (TNFalpha, TRAIL, Fas ligand), cytokines (IL-1, IFNgamma), radiation, pathogenic infections, cytotoxic agents and others. Ceramides 25-33 interferon gamma Homo sapiens 223-231 20399285-0 2010 Downregulation of IL-17 and IFN-gamma in the optic nerve by beta-elemene in experimental autoimmune encephalomyelitis. beta-elemene 60-72 interferon gamma Homo sapiens 28-37 20550764-1 2010 BACKGROUND: Interferon-gamma (IFN-gamma) release assays (IGRAs), such as the QuantiFERON-TB Gold In-Tube test (QFT-GIT), are becoming a preferred method for diagnosis of tuberculosis (TB) infection in many industrialised countries. tb gold 89-96 interferon gamma Homo sapiens 12-28 20550764-1 2010 BACKGROUND: Interferon-gamma (IFN-gamma) release assays (IGRAs), such as the QuantiFERON-TB Gold In-Tube test (QFT-GIT), are becoming a preferred method for diagnosis of tuberculosis (TB) infection in many industrialised countries. tb gold 89-96 interferon gamma Homo sapiens 30-39 20229526-0 2010 Blackcurrant proanthocyanidins augment IFN-gamma-induced suppression of IL-4 stimulated CCL26 secretion in alveolar epithelial cells. Proanthocyanidins 13-30 interferon gamma Homo sapiens 39-48 20229526-8 2010 Furthermore, both BC-P and purified EGC potentiated the ability of IFN-gamma to suppress IL-4-stimulated CCL26 secretion. bc-p 18-22 interferon gamma Homo sapiens 67-76 20229526-8 2010 Furthermore, both BC-P and purified EGC potentiated the ability of IFN-gamma to suppress IL-4-stimulated CCL26 secretion. gallocatechol 36-39 interferon gamma Homo sapiens 67-76 19997047-8 2010 Inhibition of interferon gamma and TNF-alpha production increased from 7% (+/-1%) and 31% (+/-6%) (PTX alone) to 49% (+/-2%) and 69% (+/-6%), respectively. Pentoxifylline 99-102 interferon gamma Homo sapiens 14-30 21666767-5 2010 ATRA plus IFN-gamma induced extrinsic pathway of apoptosis by activation of caspase-8 and cleavage of Bid to tBid and also down regulation of hTERT, c-IAP2, and survivin and upregulation of Smac/Diablo to promote apoptosis. tBID 109-113 interferon gamma Homo sapiens 10-19 20979795-0 2010 [The relationship between cyclic adenosine monophosphate response element-binding protein and interferon-gamma gene promoter in tuberculosis patients]. Cyclic AMP 26-56 interferon gamma Homo sapiens 94-110 20546583-5 2010 Magnesium deficiency, on the other hand, was associated with an increase in production of IL-13 by 80%; 95% CI: 31% to 371% and a reduction in IFN-gamma production. Magnesium 0-9 interferon gamma Homo sapiens 143-152 19765856-3 2010 IFN-gamma induces several biochemical pathways in human monocytes, among them neopterin formation by GTP-cyclohydrolase I (GTP-CH I) and tryptophan degradation by the enzyme indoleamine 2,3-dioxygenase (IDO). Neopterin 78-87 interferon gamma Homo sapiens 0-9 20559042-2 2010 Pentoxifylline significantly reduced circulating levels of vascular cell adhesion molecule-1 and interferon-gamma-induced protein and significantly improved endothelial function during the 8-week trial. Pentoxifylline 0-14 interferon gamma Homo sapiens 97-113 20207200-5 2010 Moreover, the inflammatory cytokines, IFN-gamma and IL-1beta, produced by hPBMCs upon activation notably upregulated the expression of cyclooxygenase-2 (COX-2) and the production of PGE(2) by hUC-MSCs. Prostaglandins E 182-185 interferon gamma Homo sapiens 38-47 19765856-3 2010 IFN-gamma induces several biochemical pathways in human monocytes, among them neopterin formation by GTP-cyclohydrolase I (GTP-CH I) and tryptophan degradation by the enzyme indoleamine 2,3-dioxygenase (IDO). Tryptophan 137-147 interferon gamma Homo sapiens 0-9 19765856-7 2010 Stimulation of CD34(+) cells with IFN-gamma in different doses (either 5000U/ml once or 200 and 400U/ml every other day) induced tryptophan degradation and in parallel also neopterin formation. Tryptophan 129-139 interferon gamma Homo sapiens 34-43 19765856-7 2010 Stimulation of CD34(+) cells with IFN-gamma in different doses (either 5000U/ml once or 200 and 400U/ml every other day) induced tryptophan degradation and in parallel also neopterin formation. Neopterin 173-182 interferon gamma Homo sapiens 34-43 19765856-9 2010 IFN-gamma stimulated higher kynurenine and neopterin formation in cells cultivated in EGFCM, stimulation with 400U IFN-gamma every other day was most effective. Kynurenine 28-38 interferon gamma Homo sapiens 0-9 19765856-9 2010 IFN-gamma stimulated higher kynurenine and neopterin formation in cells cultivated in EGFCM, stimulation with 400U IFN-gamma every other day was most effective. Kynurenine 28-38 interferon gamma Homo sapiens 115-124 19765856-9 2010 IFN-gamma stimulated higher kynurenine and neopterin formation in cells cultivated in EGFCM, stimulation with 400U IFN-gamma every other day was most effective. Neopterin 43-52 interferon gamma Homo sapiens 0-9 19765856-9 2010 IFN-gamma stimulated higher kynurenine and neopterin formation in cells cultivated in EGFCM, stimulation with 400U IFN-gamma every other day was most effective. Neopterin 43-52 interferon gamma Homo sapiens 115-124 19765856-11 2010 In conclusion, stimulation of haematopoietic stem cells with IFN-gamma activates IDO and neopterin formation, and it also exerts an influence on the proliferation of various stem cell populations. Neopterin 89-98 interferon gamma Homo sapiens 61-70 20483782-6 2010 We also demonstrate that IFN-gamma treatment, which is used to induce IgG2a switching, increases intracellular ROS levels, and activates p53 in switching B cells, and show that p53 inhibits IgG2a class switching through its antioxidant-regulating function. Reactive Oxygen Species 111-114 interferon gamma Homo sapiens 25-34 20622274-0 2010 The nitric oxide production in monocytes and macrophages of the Chlamydia trachomatis-infected patients depends on the IFN gamma and tnf alpha amount. Nitric Oxide 4-16 interferon gamma Homo sapiens 119-142 20571305-2 2010 The aim of this study was to evaluate the usefulness of in vitro interferon-gamma (INF-gamma) assay for differential diagnosis between ITB and CD. ITB 301 135-138 interferon gamma Homo sapiens 65-81 19428234-10 2010 Moreover, tryptophan reduced the expression of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-6, interferon (IFN)-gamma, IL-12p40, IL-1beta and IL-17, as well as IL-8 and intracellular adhesion molecule-1, and resulted in increased expression of apoptosis initiators caspase-8 and Bax. Tryptophan 10-20 interferon gamma Homo sapiens 127-149 20631892-3 2010 Treatment of astrocytes with bezafibrate and fenofibrate (0, 5, and 10 microM) reduced the IFNgamma and IL-1beta-induced cell proliferation in a dose-dependent manner. Bezafibrate 29-40 interferon gamma Homo sapiens 91-99 20631892-3 2010 Treatment of astrocytes with bezafibrate and fenofibrate (0, 5, and 10 microM) reduced the IFNgamma and IL-1beta-induced cell proliferation in a dose-dependent manner. Fenofibrate 45-56 interferon gamma Homo sapiens 91-99 20571305-2 2010 The aim of this study was to evaluate the usefulness of in vitro interferon-gamma (INF-gamma) assay for differential diagnosis between ITB and CD. ITB 301 135-138 interferon gamma Homo sapiens 83-92 20815274-1 2010 OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma). tripterygium glycosides 62-85 interferon gamma Homo sapiens 274-290 20487639-5 2010 The biological activity of rhscIL-27 was detected by IFN-gamma inducing assay. rhscil-27 27-36 interferon gamma Homo sapiens 53-62 20815274-1 2010 OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma). tripterygium glycosides 62-85 interferon gamma Homo sapiens 292-301 20815274-1 2010 OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Thioguanine 87-89 interferon gamma Homo sapiens 274-290 20504369-9 2010 CSE effects on IFN-gamma-induced Stat1 activation, antiviral protein expression, and inhibition of RSV infection were decreased by glutathione augmentation of epithelial cells using N-acetylcysteine or glutathione monoethyl ester, providing one strategy to alter cigarette smoke effects. Glutathione 131-142 interferon gamma Homo sapiens 15-24 20815274-1 2010 OBJECTIVE: To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet"s disease (BD) through observing its effect on serum levels of interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Thioguanine 87-89 interferon gamma Homo sapiens 292-301 20504369-9 2010 CSE effects on IFN-gamma-induced Stat1 activation, antiviral protein expression, and inhibition of RSV infection were decreased by glutathione augmentation of epithelial cells using N-acetylcysteine or glutathione monoethyl ester, providing one strategy to alter cigarette smoke effects. Acetylcysteine 182-198 interferon gamma Homo sapiens 15-24 20504369-9 2010 CSE effects on IFN-gamma-induced Stat1 activation, antiviral protein expression, and inhibition of RSV infection were decreased by glutathione augmentation of epithelial cells using N-acetylcysteine or glutathione monoethyl ester, providing one strategy to alter cigarette smoke effects. S-ethyl glutathione 202-229 interferon gamma Homo sapiens 15-24 20559033-8 2010 CONCLUSIONS: LB is associated with inadequate suppression of peripheral blood T-cell granzyme B, IFN-gamma, and TNF-alpha. lb 13-15 interferon gamma Homo sapiens 97-106 20508866-11 2010 In vitro, CsA significantly inhibited the production of IL-17 and IFN-gamma by PBMCs activated with anti-CD3 and anti-CD28 antibodies or phorbol 12-myristate,13-acetate and ionomycin in BD patients with active uveitis. Cyclosporine 10-13 interferon gamma Homo sapiens 66-75 20508866-13 2010 CONCLUSIONS: Our findings showed that CsA can significantly inhibit the intraocular inflammation of BD patients and the expression of IL-17 and IFN-gamma in vivo and in vitro. Cyclosporine 38-41 interferon gamma Homo sapiens 144-153 20508866-14 2010 The results suggested that the inhibitory effect of CsA on uveitis in BD patients may be partially mediated through inhibiting the production of IL-17 and IFN-gamma. Cyclosporine 52-55 interferon gamma Homo sapiens 155-164 20230918-5 2010 Our results demonstrate that ginsenoside Re enhanced viability of CD4(+) T cells through the regulation of IFN-gamma-dependent autophagy activity. Ginsenosides 29-40 interferon gamma Homo sapiens 107-116 20394727-7 2010 In the same co-culture system, donor PUVA-SPs enhanced production of interleukin-10 and interferon-gamma by recipient DCs and impaired the subsequent capability of recipient DCs to stimulate recipient naive T cells. puva-sps 37-45 interferon gamma Homo sapiens 88-104 20337621-4 2010 The CD4(+)CD28(+) percentage (p < 0.0001) and the ratio of interferon-gamma:interleukin-4 (p = 0.001) all increased with propofol but showed no change with isoflurane. Propofol 124-132 interferon gamma Homo sapiens 62-78 20060887-6 2010 Addition of Abeta-specific Th2 cells suppressed the Abeta-induced IFN-gamma production by Th1 cells and IL-17 production by Th17 cells with glia as the APC. UNII-042A8N37WH 12-17 interferon gamma Homo sapiens 66-75 20059479-3 2010 CAPE significantly suppressed interferon (IFN)-gamma and interleukin (IL)-5 production and proliferation of CD4+ T cells stimulated by soluble anti-CD3 and anti-CD28 monoclonal antibodies in both healthy subjects and asthmatic patients. caffeic acid phenethyl ester 0-4 interferon gamma Homo sapiens 30-52 20072849-6 2010 Interestingly, in the treatment-naive group, short-term prednisolone significantly increased LPS-induced TNF-alpha and IFN-gamma productions by PBMCs. Prednisolone 56-68 interferon gamma Homo sapiens 119-128 20007908-6 2010 Specific interactions among the studied bacteria, gliadins, and IFN-gamma, which favored the CD immune features, were also detected. Cadmium 93-95 interferon gamma Homo sapiens 64-73 20007908-7 2010 Therefore, intestinal bacteria could be additional factors that regulate the ability of monocytes recruited to the mucosa to respond to gliadins and IFN-gamma in CD patients, influencing the course of the disease. Cadmium 162-164 interferon gamma Homo sapiens 149-158 20164222-2 2010 To date, T-cell-based AIDS vaccines have been evaluated with validated techniques that measure the number of CD8(+) T cells in the blood that secrete cytokines, mainly gamma interferon (IFN-gamma), in response to synthetic peptides. Peptides 223-231 interferon gamma Homo sapiens 168-195 20219775-3 2010 We have previously shown that cytokines, known to be produced by uterine natural killer (uNK) cells, such as TNF-alpha, TGF-beta1 and IFN-gamma inhibit EVT invasion. EVT 152-155 interferon gamma Homo sapiens 134-143 19835489-2 2010 Voriconazole induction, including the utilization of voriconazole therapeutic drug monitoring in both serum and CSF, with transition to voriconazole plus interferon-gamma (IFN-gamma) was successfully used in a patient receiving antiretroviral therapy with abacavir/lamivudine and lopinavir/ritonavir. abacavir 256-264 interferon gamma Homo sapiens 172-181 20457620-4 2010 We show that IFNgamma, but not IFNalpha, IFNbeta, or fulvestrant (ICI; ICI 182,780; Faslodex), induces IRF1 expression in antiestrogen-resistant MCF7/LCC9 and LY2 cells. Fulvestrant 84-92 interferon gamma Homo sapiens 13-21 19835489-2 2010 Voriconazole induction, including the utilization of voriconazole therapeutic drug monitoring in both serum and CSF, with transition to voriconazole plus interferon-gamma (IFN-gamma) was successfully used in a patient receiving antiretroviral therapy with abacavir/lamivudine and lopinavir/ritonavir. Lamivudine 265-275 interferon gamma Homo sapiens 172-181 19835489-2 2010 Voriconazole induction, including the utilization of voriconazole therapeutic drug monitoring in both serum and CSF, with transition to voriconazole plus interferon-gamma (IFN-gamma) was successfully used in a patient receiving antiretroviral therapy with abacavir/lamivudine and lopinavir/ritonavir. Lopinavir 280-289 interferon gamma Homo sapiens 172-181 19835489-2 2010 Voriconazole induction, including the utilization of voriconazole therapeutic drug monitoring in both serum and CSF, with transition to voriconazole plus interferon-gamma (IFN-gamma) was successfully used in a patient receiving antiretroviral therapy with abacavir/lamivudine and lopinavir/ritonavir. Ritonavir 290-299 interferon gamma Homo sapiens 172-181 20207585-3 2010 Pro-inflammatory cytokines, e.g. interferon-gamma (IFN-gamma), are the primary inducers of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and of neopterin biosynthesis by GTP-cyclohydrolase I. Tryptophan 91-101 interferon gamma Homo sapiens 33-49 20334925-8 2010 Exogenous guanosine antagonized the effect of MPA on the phenotype of TNFalpha-matured-DC as well as the IL-12p70 and IFN gamma secretion induced by both stimuli, without affecting p38MAPK phosphorylation. Guanosine 10-19 interferon gamma Homo sapiens 118-127 20207585-3 2010 Pro-inflammatory cytokines, e.g. interferon-gamma (IFN-gamma), are the primary inducers of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and of neopterin biosynthesis by GTP-cyclohydrolase I. Tryptophan 91-101 interferon gamma Homo sapiens 51-60 20207585-3 2010 Pro-inflammatory cytokines, e.g. interferon-gamma (IFN-gamma), are the primary inducers of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and of neopterin biosynthesis by GTP-cyclohydrolase I. Neopterin 160-169 interferon gamma Homo sapiens 33-49 20207585-3 2010 Pro-inflammatory cytokines, e.g. interferon-gamma (IFN-gamma), are the primary inducers of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and of neopterin biosynthesis by GTP-cyclohydrolase I. Neopterin 160-169 interferon gamma Homo sapiens 51-60 20179574-9 2010 CONCLUSION: In all the aforementioned phases of HIV infection, the large majority of gag-specific CD4 T lymphocytes cannot be identified by the sole expression of interleukin-2 and interferon-gamma, which is early impaired. Glycosaminoglycans 85-88 interferon gamma Homo sapiens 181-197 20045653-6 2010 Following stimulation with phorbol ester and ionomycin, PBMCs taken from MS patients in relapse developed a more inflammatory profile than those taken from controls or non-relapse patients, with greater expression of CD154, IL-17 and dual expression of IL-17/IFN-gamma. Phorbol Esters 27-40 interferon gamma Homo sapiens 259-268 20053369-3 2010 STZ administration elevated the levels of IL-2 as well as IFN-gamma and attenuated the level of TNF-alpha in the sera of diabetic animals. Streptozocin 0-3 interferon gamma Homo sapiens 58-67 27713291-6 2010 TNF-alpha and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 177-187 interferon gamma Homo sapiens 14-23 20045653-6 2010 Following stimulation with phorbol ester and ionomycin, PBMCs taken from MS patients in relapse developed a more inflammatory profile than those taken from controls or non-relapse patients, with greater expression of CD154, IL-17 and dual expression of IL-17/IFN-gamma. Ionomycin 45-54 interferon gamma Homo sapiens 259-268 19046782-5 2010 We found that lovastatin, but not atorvastatin, can dose-dependently inhibit cytokine production such as interleukin-2, interleukin-4, and interferon-gamma from activated human T cells. Lovastatin 14-24 interferon gamma Homo sapiens 139-155 20074601-4 2010 In vitro stimulation of lymph node cells with either TG, staphylococcus enterotoxin B, or phorbol 12-myristate 13-acetate/ionomycin revealed an interferon-gamma expression in T-bet(+) B cells only in the patient and not in controls. Boron 84-85 interferon gamma Homo sapiens 144-160 20074601-4 2010 In vitro stimulation of lymph node cells with either TG, staphylococcus enterotoxin B, or phorbol 12-myristate 13-acetate/ionomycin revealed an interferon-gamma expression in T-bet(+) B cells only in the patient and not in controls. Tetradecanoylphorbol Acetate 90-121 interferon gamma Homo sapiens 144-160 20074601-4 2010 In vitro stimulation of lymph node cells with either TG, staphylococcus enterotoxin B, or phorbol 12-myristate 13-acetate/ionomycin revealed an interferon-gamma expression in T-bet(+) B cells only in the patient and not in controls. Ionomycin 122-131 interferon gamma Homo sapiens 144-160 19919955-8 2010 LPS plus IFN-gamma-treated macrophages produce a larger amount of nitric oxide (NO) in comparison with LPS-treated cells. Nitric Oxide 66-78 interferon gamma Homo sapiens 9-18 20487634-4 2010 In LPS-stimulated cultures, release of IFN-gamma, TNF-alpha, IL-10 and IL-17 was inhibited by Pd salt, whereas IFN-gamma release was enhanced and TNF-alpha and IL-17 release was inhibited by Pd nanoparticles. pd salt 94-101 interferon gamma Homo sapiens 39-48 20487634-4 2010 In LPS-stimulated cultures, release of IFN-gamma, TNF-alpha, IL-10 and IL-17 was inhibited by Pd salt, whereas IFN-gamma release was enhanced and TNF-alpha and IL-17 release was inhibited by Pd nanoparticles. Palladium 94-96 interferon gamma Homo sapiens 39-48 20049854-3 2010 In senescent fibroblasts and interferon-gamma (IFNgamma) treated fibroblasts, both calnexin and CyCAP form larger polymers and are released from the endoplasmic reticulum (ER) through the cellular membrane to the extracellular area. Polymers 114-122 interferon gamma Homo sapiens 47-55 20093028-0 2010 T cells from patients with Guillain-Barre syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1. Gangliosides 112-123 interferon gamma Homo sapiens 59-75 20093028-0 2010 T cells from patients with Guillain-Barre syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1. G(M1) Ganglioside 124-127 interferon gamma Homo sapiens 59-75 20093028-8 2010 There was significantly increased production of interferon-gamma but not interleukin-5 in response to stimulation with the ganglioside GM1. Gangliosides 123-134 interferon gamma Homo sapiens 48-64 20093028-8 2010 There was significantly increased production of interferon-gamma but not interleukin-5 in response to stimulation with the ganglioside GM1. G(M1) Ganglioside 135-138 interferon gamma Homo sapiens 48-64 20071569-2 2010 Gamma interferon (IFN-gamma) is a key regulator of chronic murine gammaherpesvirus 68 (gammaHV68) infection and a potent inhibitor of gammaHV68 reactivation from latency. gammahv68 87-96 interferon gamma Homo sapiens 18-27 20445345-6 2010 Compared with a water-in-oil emulsion vaccine, DPX-0907 enhanced IFN-gamma+CD8+ T cells in vaccine site-draining lymph nodes, as seen by immunofluorescence staining and increased the frequency of IFN-gamma+ lymph node cells as seen by enzyme-linked immunosorbent spot assay. 1,3-diethyl-8-phenylxanthine 47-50 interferon gamma Homo sapiens 65-74 20445345-6 2010 Compared with a water-in-oil emulsion vaccine, DPX-0907 enhanced IFN-gamma+CD8+ T cells in vaccine site-draining lymph nodes, as seen by immunofluorescence staining and increased the frequency of IFN-gamma+ lymph node cells as seen by enzyme-linked immunosorbent spot assay. 1,3-diethyl-8-phenylxanthine 47-50 interferon gamma Homo sapiens 196-205 20026404-6 2010 After stimulation of MC with the cytokines TNF-alpha, IL-1beta and IFN-gamma alone or in combination to simulate a proinflammatory milieu as would occur during immune-mediated inflammatory disease, an upregulation of TLR3 is seen. Methylcholanthrene 21-23 interferon gamma Homo sapiens 67-76 20071569-3 2010 Macrophages are the cell type that is responsive to the IFN-gamma-mediated control of gammaHV68 reactivation; however, the molecular mechanism of this IFN-gamma action is undefined. gammahv68 86-95 interferon gamma Homo sapiens 56-65 20071569-3 2010 Macrophages are the cell type that is responsive to the IFN-gamma-mediated control of gammaHV68 reactivation; however, the molecular mechanism of this IFN-gamma action is undefined. gammahv68 86-95 interferon gamma Homo sapiens 151-160 19898919-3 2010 MTB antigen (ESAT-6 and CFP-10)-induced IFN-gamma-releasing assay was performed with or without addition of biologics (TCZ, ETA, and INF) using whole blood from patients with active TB. Terbium 1-3 interferon gamma Homo sapiens 40-49 19898919-1 2010 Interferon gamma (IFN-gamma) production is a critical step of antituberculosis (anti-TB) immune response. Terbium 85-87 interferon gamma Homo sapiens 0-27 20560354-0 2010 [Recombinant cIL-18-binding protein as an antagonist to cIL-18 enhanced PBMCs secreting IFN-gamma]. cil-18 13-19 interferon gamma Homo sapiens 88-97 20560354-5 2010 The biologic activity of recombinant proteins binding with cIL-18 was measured, inhibiting the activity of cIL-18 enhancing relative cells secreting IFN-gamma was confirmed through ELISA. Fenofibrate 59-62 interferon gamma Homo sapiens 149-158 20560354-5 2010 The biologic activity of recombinant proteins binding with cIL-18 was measured, inhibiting the activity of cIL-18 enhancing relative cells secreting IFN-gamma was confirmed through ELISA. Fenofibrate 107-110 interferon gamma Homo sapiens 149-158 20560354-9 2010 CONCLUSION: The experiment indicates that recombinant cIL-18BP can inhibit the activity of cIL-18 stimulating related immune cells secreting IFN-gamma. cil-18 54-60 interferon gamma Homo sapiens 141-150 20416182-20 2010 PGE2 influences the production of IFN-gamma and IL-4, and significantly influences peak appearance of IFN-gamma produced by T lymphocyte. Dinoprostone 0-4 interferon gamma Homo sapiens 34-43 20416182-20 2010 PGE2 influences the production of IFN-gamma and IL-4, and significantly influences peak appearance of IFN-gamma produced by T lymphocyte. Dinoprostone 0-4 interferon gamma Homo sapiens 102-111 20416182-21 2010 PGE2 can continuously inhibit the production of IFN-gamma, but its continuous effect on IL-4 is no significant. Dinoprostone 0-4 interferon gamma Homo sapiens 48-57 19896472-5 2010 Both KR62980 and rosiglitazone suppressed IFNgamma production in a dose-dependent manner, whereas IL-4 gene expression was specifically suppressed by only KR62980. 1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester 5-12 interferon gamma Homo sapiens 42-50 20368109-9 2010 Western blot showed recombinant protein can specificly reacted with anti-human HMGB1 polyclonal antibody and anti-His-Tag polyclonal antibody.The purpose protein was found more than 90% after purified, and can effectively inhibit the production of BAFF, IFN-gamma and TNF-alpha in monocyte which were induced by IC. Histidine 114-117 interferon gamma Homo sapiens 254-263 20368114-2 2010 METHODS: RT-PCR and MTT methods were used to detect the effect on MICA mRNA expression induced by IFN-gamma in the edited A549 cells and the change of CIK killing sensitivity to A549 cells, respectively. monooxyethylene trimethylolpropane tristearate 20-23 interferon gamma Homo sapiens 98-107 20081091-3 2010 In this study, using the isoform-selective inhibitor IC87114, we show that sustained p110delta activity is required for interferon-gamma production. IC 87114 53-60 interferon gamma Homo sapiens 120-136 19896472-5 2010 Both KR62980 and rosiglitazone suppressed IFNgamma production in a dose-dependent manner, whereas IL-4 gene expression was specifically suppressed by only KR62980. Rosiglitazone 17-30 interferon gamma Homo sapiens 42-50 20035145-8 2010 The proportion of IFN-gamma-producing CD8+ T cells was correlated negatively with single-breath carbon monoxide transfer coefficient (Kco)(rho=-0.45, p=0.033) and positively with eNO (rho=0.50, p=0.012). Carbon Monoxide 96-111 interferon gamma Homo sapiens 18-27 20205737-12 2010 There was no difference in TNF and IL-2 concentrations, but plasma IFN-gamma and IL-6 increased on wk 8 in subjects given 8 mg astaxanthin. astaxanthine 127-138 interferon gamma Homo sapiens 67-76 20002447-7 2010 In vitro, contemporaneous C5a and interferon-gamma signalling enhanced nitric oxide production, accompanied by down-regulation of the inhibitory myeloid CD200 receptor, contributing to cell activation. Nitric Oxide 71-83 interferon gamma Homo sapiens 34-50 20088798-7 2010 Lenalidomide alone increased T cell production of IL-2, and NK cell production of interferon-gamma and granzyme B. Lenalidomide 0-12 interferon gamma Homo sapiens 82-98 20118567-6 2010 In contrast, nifedipine and verapamil suppressed the production of IL-1beta, TNF-alpha, and IFN-gamma. Nifedipine 13-23 interferon gamma Homo sapiens 92-101 20118567-6 2010 In contrast, nifedipine and verapamil suppressed the production of IL-1beta, TNF-alpha, and IFN-gamma. Verapamil 28-37 interferon gamma Homo sapiens 92-101 20118567-8 2010 Nifedipine inhibited production of IL-1alpha, IL-6, and IFN-gamma. Nifedipine 0-10 interferon gamma Homo sapiens 56-65 20118567-9 2010 Verapamil suppressed production of IFN-gamma. Verapamil 0-9 interferon gamma Homo sapiens 35-44 20039303-1 2010 Iron metabolism in inflammation has been mostly characterized in macrophages exposed to pathogens or inflammatory conditions, mimicked by the combined action of LPS and IFN-gamma (M1 polarization). Iron 0-4 interferon gamma Homo sapiens 169-178 19914403-0 2010 Suppressive effect of diazepam on IFN-gamma production by human T cells. Diazepam 22-30 interferon gamma Homo sapiens 34-43 19914403-2 2010 In the present study, we revealed that diazepam, a mixed-type benzodiazepine, inhibited IFN-gamma production by human peripheral blood mononuclear cells (PBMCs) induced by anti-CD3 in dose-dependent manner. Diazepam 39-47 interferon gamma Homo sapiens 88-97 19914403-2 2010 In the present study, we revealed that diazepam, a mixed-type benzodiazepine, inhibited IFN-gamma production by human peripheral blood mononuclear cells (PBMCs) induced by anti-CD3 in dose-dependent manner. Benzodiazepines 62-76 interferon gamma Homo sapiens 88-97 19914403-3 2010 Flow cytometry analysis demonstrated that diazepam could inhibit the frequency of IFN-gamma-producing CD4(+) and CD8(+) T cells. Diazepam 42-50 interferon gamma Homo sapiens 82-91 19914403-4 2010 The inhibitory effect of diazepam on IFN-gamma production is similar to that of R(0)5-4864, a selective PBRs ligand. Diazepam 25-33 interferon gamma Homo sapiens 37-46 20122816-8 2010 In contrast, treatment with PMA and IFNgamma reduced the RARgamma and RXRalpha protein expression (preventable by the proteasome inhibitor MG132), increased the accumulation of [(3)H]RA and/or [(3)H]ddRA in the cells, and changed the CRABPII transcription. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 139-144 interferon gamma Homo sapiens 36-44 20122816-0 2010 Keratinocyte differentiation induced by calcium, phorbol ester or interferon-gamma elicits distinct changes in the retinoid signalling pathways. Retinoids 115-123 interferon gamma Homo sapiens 66-82 19955489-3 2010 Among various subtypes of AGEs, glyceraldehyde-derived AGE (AGE-2) and glycolaldehyde-derived AGE (AGE-3) induce the expressions of intercellular adhesion molecule-1, B7.1, B7.2, and CD40 on monocytes, the production of interferon-gamma and tumor necrosis factor-alpha, and the lymphocyte proliferation in human peripheral blood mononuclear cells. Glyceraldehyde 32-46 interferon gamma Homo sapiens 220-268 19955489-3 2010 Among various subtypes of AGEs, glyceraldehyde-derived AGE (AGE-2) and glycolaldehyde-derived AGE (AGE-3) induce the expressions of intercellular adhesion molecule-1, B7.1, B7.2, and CD40 on monocytes, the production of interferon-gamma and tumor necrosis factor-alpha, and the lymphocyte proliferation in human peripheral blood mononuclear cells. glycolaldehyde 71-85 interferon gamma Homo sapiens 220-268 19481766-9 2010 We demonstrated that cAMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB binding due to its blockade of the upstream signal(s) leading to IkappaB phosphorylation and degradation, and is mediated by PKA-independent signaling pathways. Cyclic AMP 21-25 interferon gamma Homo sapiens 49-57 19481766-0 2010 Cyclic AMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB translocation in hepatocytes by a PKA independent mechanism. Cyclic AMP 0-10 interferon gamma Homo sapiens 34-42 19655299-0 2010 Antiinflammatory effects of a red orange extract in human keratinocytes treated with interferon-gamma and histamine. red orange 30-40 interferon gamma Homo sapiens 85-101 19481766-1 2010 We previously showed that cAMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB binding in primary hepatocytes but the signaling mechanisms responsible for this effect are not understood. Cyclic AMP 26-30 interferon gamma Homo sapiens 54-62 19481766-3 2010 Immunofluorescent staining showed that cAMP inhibited IL-1beta plus IFNgamma-induced translocation of NF-kappaB into the nucleus. Cyclic AMP 39-43 interferon gamma Homo sapiens 68-76 19481766-4 2010 Western blot analysis showed that the IL-1beta plus IFNgamma- induced phosphorylation and degradation of IkappaBa were markedly inhibited by cAMP. Cyclic AMP 141-145 interferon gamma Homo sapiens 52-60 19481766-5 2010 Immunocomplex assay involving GST-IKK revealed that cAMP inhibited IL-1beta plus IFNgamma-induced IKK activity. Cyclic AMP 52-56 interferon gamma Homo sapiens 81-89 19655299-2 2010 The purpose of this study was to evaluate the antiinflammatory activity of a red orange (Citrus sinensis varieties: Moro, Tarocco, Sanguinello) complex (ROC), characterized by high levels of anthocyanins, flavanones, hydroxycinnamic acids and ascorbic acid, on the human keratinocyte line NCTC 2544 exposed to interferon-gamma (IFN-gamma) and histamine. red orange 77-87 interferon gamma Homo sapiens 310-326 19655299-2 2010 The purpose of this study was to evaluate the antiinflammatory activity of a red orange (Citrus sinensis varieties: Moro, Tarocco, Sanguinello) complex (ROC), characterized by high levels of anthocyanins, flavanones, hydroxycinnamic acids and ascorbic acid, on the human keratinocyte line NCTC 2544 exposed to interferon-gamma (IFN-gamma) and histamine. red orange 77-87 interferon gamma Homo sapiens 328-337 19655299-2 2010 The purpose of this study was to evaluate the antiinflammatory activity of a red orange (Citrus sinensis varieties: Moro, Tarocco, Sanguinello) complex (ROC), characterized by high levels of anthocyanins, flavanones, hydroxycinnamic acids and ascorbic acid, on the human keratinocyte line NCTC 2544 exposed to interferon-gamma (IFN-gamma) and histamine. Saquinavir 153-156 interferon gamma Homo sapiens 310-326 19655299-2 2010 The purpose of this study was to evaluate the antiinflammatory activity of a red orange (Citrus sinensis varieties: Moro, Tarocco, Sanguinello) complex (ROC), characterized by high levels of anthocyanins, flavanones, hydroxycinnamic acids and ascorbic acid, on the human keratinocyte line NCTC 2544 exposed to interferon-gamma (IFN-gamma) and histamine. Saquinavir 153-156 interferon gamma Homo sapiens 328-337 19879123-0 2010 Serial interferon-gamma release assays after rifampicin prophylaxis in a tuberculosis outbreak. Rifampin 45-55 interferon gamma Homo sapiens 7-23 20230693-5 2010 Likewise, nimesulide (1 micromol/L) enabled gammadeltaT cells to secret more of IFN-gamma and TNF-alpha (262.3 ng/L and 177.5 ng/L, respectively) than the control group (196.1 ng/L and 158.5 ng/L, respectively) (P<0.05). nimesulide 10-20 interferon gamma Homo sapiens 80-89 20230693-8 2010 CONCLUSION: Nimesulide made gammadeltaT cells to express more perforin and granzyme B and to secret more IFN-gamma and TNF-alpha into the supernatant, leading to higher killing rate of SGC-7901 and BCG-823 gastric cancer cells. nimesulide 12-22 interferon gamma Homo sapiens 105-114 19941850-8 2010 Cryptomerione also inhibited Th2 cell polarization induced by CT-primed dendritic cells, but enhanced IFN-gamma secretion by naive T cells co-cultured with CT-primed dendritic cells. cryptomerione 0-13 interferon gamma Homo sapiens 102-111 20102164-5 2010 The title method was applied to the detection of endogenously produced ROS/RNS by single IFN-gamma/LPS/PMA stimulated RAW 264.7 macrophages. ros 71-74 interferon gamma Homo sapiens 89-98 20102164-5 2010 The title method was applied to the detection of endogenously produced ROS/RNS by single IFN-gamma/LPS/PMA stimulated RAW 264.7 macrophages. Radon 75-78 interferon gamma Homo sapiens 89-98 20067767-7 2010 Furthermore, it was found that after stimulated by fucoidin-treated DCs, the CD8+ T cells can release more IFN-gamma than non-fucoidin-treated cells as detected by intracellular IFN-gamma staining. fucoidan 51-59 interferon gamma Homo sapiens 107-116 19857486-3 2010 In a previous study, we found that glyceraldehyde-derived AGE (AGE-2) and glycolaldehyde-derived AGE (AGE-3) at 100 microg/ml induced the expressions of ICAM-1 and CD40 on monocytes and the production of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha in human peripheral blood mononuclear cells. Glyceraldehyde 35-49 interferon gamma Homo sapiens 204-226 19857486-3 2010 In a previous study, we found that glyceraldehyde-derived AGE (AGE-2) and glycolaldehyde-derived AGE (AGE-3) at 100 microg/ml induced the expressions of ICAM-1 and CD40 on monocytes and the production of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha in human peripheral blood mononuclear cells. glycolaldehyde 74-88 interferon gamma Homo sapiens 204-226 19793744-7 2010 Upon treatment with TNF-alpha and IFN-gamma, both cocultures exhibited comparable effects on the trans-bilayer electrical resistance, the transport of sodium fluorescein and the increase in secondary cytokine release. Fluorescein 151-169 interferon gamma Homo sapiens 34-43 20067767-7 2010 Furthermore, it was found that after stimulated by fucoidin-treated DCs, the CD8+ T cells can release more IFN-gamma than non-fucoidin-treated cells as detected by intracellular IFN-gamma staining. fucoidan 51-59 interferon gamma Homo sapiens 178-187 19800966-6 2010 Functional analyses, including dual immunofluorescent labeling with 5-bromodeoxyuridine (BrdU) incorporation indicate that IFN-gamma treatment leads to significant GNP proliferation. Bromodeoxyuridine 68-87 interferon gamma Homo sapiens 123-132 20086177-2 2010 Anthracyclines, oxaliplatin, and ionizing irradiation activate a type of tumor cell death that elicits efficient anticancer immune responses depending on interferon gamma (IFNgamma) and the IFNgamma receptor. Anthracyclines 0-14 interferon gamma Homo sapiens 154-181 20086177-2 2010 Anthracyclines, oxaliplatin, and ionizing irradiation activate a type of tumor cell death that elicits efficient anticancer immune responses depending on interferon gamma (IFNgamma) and the IFNgamma receptor. Anthracyclines 0-14 interferon gamma Homo sapiens 172-180 20086177-2 2010 Anthracyclines, oxaliplatin, and ionizing irradiation activate a type of tumor cell death that elicits efficient anticancer immune responses depending on interferon gamma (IFNgamma) and the IFNgamma receptor. Oxaliplatin 16-27 interferon gamma Homo sapiens 154-181 20086177-2 2010 Anthracyclines, oxaliplatin, and ionizing irradiation activate a type of tumor cell death that elicits efficient anticancer immune responses depending on interferon gamma (IFNgamma) and the IFNgamma receptor. Oxaliplatin 16-27 interferon gamma Homo sapiens 172-180 19800966-6 2010 Functional analyses, including dual immunofluorescent labeling with 5-bromodeoxyuridine (BrdU) incorporation indicate that IFN-gamma treatment leads to significant GNP proliferation. Bromodeoxyuridine 89-93 interferon gamma Homo sapiens 123-132 20159692-6 2010 CONCLUSION: FK506 effectively inhibits the secretion of proinflammatory cytokines including IL-6, IFN-gamma and TNF-alpha and also the secretion of IL-2, IL-12, IL-17, GM-CSF and G-CSF. Tacrolimus 12-17 interferon gamma Homo sapiens 98-107 19846588-3 2010 Cucurbitacin R reduced the proliferation of phytohemagglutinin A-stimulated human T lymphocytes (IC(50), 18 microM), modifying the cell cycle, as well as the production of cytokines [interleukin (IL)-2, IL-4, IL-10, and especially interferon-gamma] and the induction of the principal cyclins implicated in the cell cycle (A(1), B(1), D(2), and E). cucurbitacin R 0-14 interferon gamma Homo sapiens 231-247 20159692-4 2010 RESULTS: Compared with the control group, high-concentration FK506 (20 ng/ml) significantly inhibited the secretions of IL-2, IL-6, IL-12, IL-17, IFN-gamma, TNF-alpha, GM-CSF and G-CSF. Tacrolimus 61-66 interferon gamma Homo sapiens 146-155 20056108-4 2010 We found that transfecting TE-5 and TE-9 cells with REG I Ialpha and Ibeta led to significantly increased expression of interleukin (IL)-6 mRNA and protein, but it had little or no effect on expression of IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IL-17A, interferon-gamma, tumor necrosis factor-alpha, granulocyte-colony stimulating factor or transforming growth factor-beta1. ibeta 69-74 interferon gamma Homo sapiens 252-297 19928918-8 2010 The study results demonstrate that EGCG can inhibit translocation of STAT1 into nucleus in IFN-gamma-stimulated human oral cancer cells. epigallocatechin gallate 35-39 interferon gamma Homo sapiens 91-100 19928918-10 2010 Moreover, phosphorylation of PKC-delta, JAK-1, and JAK-2, which are the upstream event for the activation of STAT1, are also inhibited by EGCG in IFN-gamma-stimulated human oral cancer cells. epigallocatechin gallate 138-142 interferon gamma Homo sapiens 146-155 19928918-11 2010 These data show that EGCG inhibited IDO expression by blocking the IFN-gamma-induced JAK-PKC-delta-STAT1 signaling pathway. epigallocatechin gallate 21-25 interferon gamma Homo sapiens 67-76 19819236-6 2010 Zn(2+) significantly reduced ion secretion elicited by carbachol (-87%) or by interferon-gamma (-100%), and inhibited the increase of intracellular Ca(2+) and nitric oxide concentrations. Zinc 0-2 interferon gamma Homo sapiens 78-94 20008150-7 2010 Lipopolysaccharide (LPS) reduced H-PGDS expression, but interferon-gamma followed by LPS induced significant PGD2 production in a delayed time course at 6 hours. Prostaglandin D2 109-113 interferon gamma Homo sapiens 56-72 19797159-7 2010 Hydrogen peroxide (H(2)O(2)) and SIN1 as well as the cytokine mixture (IFN-gamma, IL-1beta, and tumor necrosis factor-alpha) increased mRNA expression and activity of nNOS in A549 cells in a concentration-dependent manner compared with nontreated cells. Hydrogen Peroxide 0-17 interferon gamma Homo sapiens 71-80 20008150-10 2010 PGD2 synergistically enhanced CCL22/macrophage-derived chemokine synthesis in interferon-gamma-treated human keratinocytes. Prostaglandin D2 0-4 interferon gamma Homo sapiens 78-94 20834098-3 2010 The goal of the present work was to evaluate the antiviral efficacy against HBV of a thermostable IFN-gamma variant isolated using Massive Mutagenesis and thermoresistant selection (THR) technologies. Threonine 182-185 interferon gamma Homo sapiens 98-107 19951286-7 2010 Treatment with mtCCL7 produced a significant decrease in the frequency of IFN-gamma producing donor-reactive splenic T cells, reduced CCR2 expression by circulating leukocytes for 6 h (p<0.01) and blocked the normal increase in affinity of alpha4beta1 integrins for VCAM-1 following transient chemokine stimulation. mtccl7 15-21 interferon gamma Homo sapiens 74-83 19834108-5 2010 Using lucigenin-enhanced chemiluminescence and dihydroethidium assays, real-time polymerase chain reaction, and Western blot analysis, we found that JAK/STAT inhibitors significantly diminished the IFNgamma-dependent upregulation of Nox activity, Nox1 and Nox4 expression. 10,10'-dimethyl-9,9'-biacridinium 6-15 interferon gamma Homo sapiens 198-206 19834108-5 2010 Using lucigenin-enhanced chemiluminescence and dihydroethidium assays, real-time polymerase chain reaction, and Western blot analysis, we found that JAK/STAT inhibitors significantly diminished the IFNgamma-dependent upregulation of Nox activity, Nox1 and Nox4 expression. dihydroethidium 47-62 interferon gamma Homo sapiens 198-206 20167057-11 2010 In the presence of 1 to 10 microg/ml PPS, a 38% reduction in IL-4/IFNgamma-induced MPC apoptosis was observed. Pentosan Sulfuric Polyester 37-40 interferon gamma Homo sapiens 66-74 20834098-12 2010 CONCLUSIONS: These results confirm that the THR method can be used to isolate mutants with enhanced thermostability and demonstrate that a thermostable IFN-gamma variant presents antiviral properties against HBV replication. Threonine 44-47 interferon gamma Homo sapiens 152-161 20410589-4 2010 Al-though alpha-galactosylceramide (alpha-GalCer) presented by CD11c-positive cells induced both interferon-gamma (IFN-gamma) and IL-4 release, all of AGLs presented by CD11c-positive cells and AGL-1 presented by B cells induced IL-4 release from iNKT hybridoma cells. alpha-galactosylceramide 10-34 interferon gamma Homo sapiens 97-113 19932682-0 2010 Docosahexaenoic acid downregulates interferon gamma-induced expression of CXCL16 in human aortic smooth muscle cells. Docosahexaenoic Acids 0-20 interferon gamma Homo sapiens 35-51 19932682-4 2010 Docosahexaenoic acid (DHA), an omega-3 fatty acid, is known to inhibit IFNgamma signaling in inflammatory cells. Docosahexaenoic Acids 0-20 interferon gamma Homo sapiens 71-79 19932682-4 2010 Docosahexaenoic acid (DHA), an omega-3 fatty acid, is known to inhibit IFNgamma signaling in inflammatory cells. Docosahexaenoic Acids 22-25 interferon gamma Homo sapiens 71-79 19932682-4 2010 Docosahexaenoic acid (DHA), an omega-3 fatty acid, is known to inhibit IFNgamma signaling in inflammatory cells. Fatty Acids, Omega-3 31-49 interferon gamma Homo sapiens 71-79 19932682-5 2010 Therefore, we have investigated the effects of DHA treatment on the ability of IFNgamma to induce CXCL16 expression in human aortic smooth muscle cells. Docosahexaenoic Acids 47-50 interferon gamma Homo sapiens 79-87 19932682-6 2010 We observed that DHA treatment significantly reduced IFNgamma-induced CXCL16 expression. Docosahexaenoic Acids 17-20 interferon gamma Homo sapiens 53-61 19932682-8 2010 Furthermore, IFNgamma-induced STAT1 phosphorylation was inhibited by DHA, suggesting a potential mechanism. Docosahexaenoic Acids 69-72 interferon gamma Homo sapiens 13-21 19932682-9 2010 In conclusion, our data suggest inhibition of IFNgamma signaling as one of the mechanisms behind the beneficial effects of DHA during atherosclerosis. Docosahexaenoic Acids 123-126 interferon gamma Homo sapiens 46-54 20410589-4 2010 Al-though alpha-galactosylceramide (alpha-GalCer) presented by CD11c-positive cells induced both interferon-gamma (IFN-gamma) and IL-4 release, all of AGLs presented by CD11c-positive cells and AGL-1 presented by B cells induced IL-4 release from iNKT hybridoma cells. alpha-galactosylceramide 10-34 interferon gamma Homo sapiens 115-124 19500901-3 2010 Neopterin is released in large amounts from human monocyte-derived macrophages and dendritic cells preferentially following stimulation with the pro-inflammatory cytokine interferon-gamma, thus reflecting the immune activation status. Neopterin 0-9 interferon gamma Homo sapiens 171-187 20530904-4 2010 The transport rate for Di-CS was also increased by treating the cell monolayers with such tight junction-opening agents as interferon-gamma. di-cs 23-28 interferon gamma Homo sapiens 123-139 20189551-6 2010 The treatment with IFN-gamma and LPS up-regulated intracellular TRAIL expression in CBMC, but did not induce its release. cbmc 84-88 interferon gamma Homo sapiens 19-28 20299009-0 2010 IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan. Hyaluronic Acid 81-91 interferon gamma Homo sapiens 0-8 20299009-1 2010 The objective was to assess outcomes of IFNgamma-priming upon macrophage activation by the synovial macromolecule high molecular weight hyaluronan [HMW-HA] in the context of rheumatoid arthritis inflammation. Hyaluronic Acid 136-146 interferon gamma Homo sapiens 40-48 20621290-0 2010 Lenalidomide down regulates the production of interferon-gamma and the expression of inhibitory cytotoxic receptors of human Natural Killer cells. Lenalidomide 0-12 interferon gamma Homo sapiens 46-62 20621290-2 2010 The effect of Lenalidomide towards Peripheral Blood Mononuclear Cells (PBMC) has been studied and direct effects towards T cells have been described, such as an increase of interferon-gamma (IFN-gamma) and interleukin (IL)-2 production. Lenalidomide 14-26 interferon gamma Homo sapiens 173-189 20621290-5 2010 Here we show that Lenalidomide can inhibit the production of IFN-gamma by NK cells from healthy donors. Lenalidomide 18-30 interferon gamma Homo sapiens 61-70 20719078-10 2010 The production of cytokine/chemokine including IL-1beta, TNF-alpha, IFN-gamma, IL-6, IL-8, MIP-1beta, MCP-1, and RANTES but not tissue factor from the OptiPrep group was significantly lower during 48-h culture after isolation. iodixanol 151-159 interferon gamma Homo sapiens 68-77 22615589-2 2010 Setarud (IMOD) as a mixture of urtica, carotenoids, urea, and selenium has been recently patented for its potential in reduction of Tumor Necrosis Factor alpha (TNF-alpha) and Interferon-gamma and Interleukin-2 levels. Selenium 62-70 interferon gamma Homo sapiens 176-192 21086789-2 2010 During immune response interferon-gamma stimulates the kynurenine (Kyn) pathway, a major route of L-tryptophan (Trp) degradation. Kynurenine 55-65 interferon gamma Homo sapiens 23-39 21086789-2 2010 During immune response interferon-gamma stimulates the kynurenine (Kyn) pathway, a major route of L-tryptophan (Trp) degradation. Kynurenine 67-70 interferon gamma Homo sapiens 23-39 21086789-2 2010 During immune response interferon-gamma stimulates the kynurenine (Kyn) pathway, a major route of L-tryptophan (Trp) degradation. Tryptophan 98-110 interferon gamma Homo sapiens 23-39 21086789-2 2010 During immune response interferon-gamma stimulates the kynurenine (Kyn) pathway, a major route of L-tryptophan (Trp) degradation. Tryptophan 112-115 interferon gamma Homo sapiens 23-39 19249120-1 2010 High Mphi:T cell ratios suppress the immune response to the retroviral superantigen Mls by IFNgamma-triggered production of the arg- and trp-consuming enzymes iNOS and IDO. Arginine 128-131 interferon gamma Homo sapiens 91-99 20825636-6 2010 At T2, there was a significant IFN-gamma gene down-regulation in DAA+ but not in DAA- patients (-0.34 (-0.62; +1.54) vs. +1.41 (+0.35; +5.87), P = 0.008). daa 65-68 interferon gamma Homo sapiens 31-40 20825636-7 2010 In survivors, DAA administration was associated with a down-expression of both IFN-gamma (-0.65 (-0.93; 0.48) vs. +0.7 (-0.04; +1.26), P = 0.01) and IL-10 (-0.78 (-0.92; -0.6) vs. -0.18 (-0.68; +0.46), P = 0.038). daa 14-17 interferon gamma Homo sapiens 79-88 19249120-1 2010 High Mphi:T cell ratios suppress the immune response to the retroviral superantigen Mls by IFNgamma-triggered production of the arg- and trp-consuming enzymes iNOS and IDO. Tryptophan 137-140 interferon gamma Homo sapiens 91-99 20871847-10 2010 In the active vitamin D group, we found a significant median percent decline in levels of GM-CSF (-62.9%, P < .0001), IFN-gamma (-38.9%, P < .0001), IL-4 (-50.8%, P = .001), IL-8 (-48.4%, P < .0001), and IL-10 (-70.4%, P < .0001). Vitamin D 14-23 interferon gamma Homo sapiens 121-130 21229844-7 2010 It was observed that challenging the lymphocytes with 35-kDa antigen, the cell wall antigen and M. leprae soluble antigen minus LAM resulted in increased levels of IFN-gamma whereas challenge with 35-kDa antigen and M. leprae cell wall antigen resulted in increased levels of TNF-alpha. lipoarabinomannan 128-131 interferon gamma Homo sapiens 164-173 20523061-8 2010 In contrast, salbutamol significantly inhibited the spontaneous and ionomycin- plus PMA-stimulated production of IFN-gamma by PBMCs from asthmatics. Albuterol 13-23 interferon gamma Homo sapiens 113-122 20523061-8 2010 In contrast, salbutamol significantly inhibited the spontaneous and ionomycin- plus PMA-stimulated production of IFN-gamma by PBMCs from asthmatics. Ionomycin 68-77 interferon gamma Homo sapiens 113-122 20523061-8 2010 In contrast, salbutamol significantly inhibited the spontaneous and ionomycin- plus PMA-stimulated production of IFN-gamma by PBMCs from asthmatics. Tetradecanoylphorbol Acetate 84-87 interferon gamma Homo sapiens 113-122 20523061-12 2010 CONCLUSIONS: Salbutamol inhibits IFN-gamma and enhances IL-13 production by PBMCs from asthmatics. Albuterol 13-23 interferon gamma Homo sapiens 33-42 22084593-2 2010 Among other tumoricidal biochemical pathways, IFN-gamma induces the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) in a variety of cells including macrophages, dendritic cells (DCs) and tumor cells. Tryptophan 68-78 interferon gamma Homo sapiens 46-55 21391412-2 2010 However, the influence of the serotonin and noradrenalin reuptake inhibitor (SNRI) venlafaxine and its metabolite O-desmethylvenlafaxine on the stimulated blood cell secretion of IFN-gamma has not been studied so far. Serotonin 30-39 interferon gamma Homo sapiens 179-188 21391412-2 2010 However, the influence of the serotonin and noradrenalin reuptake inhibitor (SNRI) venlafaxine and its metabolite O-desmethylvenlafaxine on the stimulated blood cell secretion of IFN-gamma has not been studied so far. Venlafaxine Hydrochloride 83-94 interferon gamma Homo sapiens 179-188 21391412-2 2010 However, the influence of the serotonin and noradrenalin reuptake inhibitor (SNRI) venlafaxine and its metabolite O-desmethylvenlafaxine on the stimulated blood cell secretion of IFN-gamma has not been studied so far. Desvenlafaxine Succinate 114-136 interferon gamma Homo sapiens 179-188 21391412-6 2010 Planned contrasts revealed that compared to non-supplemented blood, four of the blood samples supplemented with the tricyclic antidepressants (TCAs) reduced IFN-gamma levels: amitriptyline (adjusted p-value (p = 0.004), nortriptyline (p = 0.037), imipramine (p = 0.021), and desipramine (p = 0.048). Amitriptyline 175-188 interferon gamma Homo sapiens 157-166 20110595-5 2010 Basal and PMA-stimulated levels of IFN-gamma, TNF-alpha, and IL-6 were measured by ELISPOT (PBMC culture supernatant). Tetradecanoylphorbol Acetate 10-13 interferon gamma Homo sapiens 35-44 20413861-8 2010 Stimulation by rAbeta42 also induces the production of the pro-inflammatory cytokines IL-1beta, IL-6, IFN-gamma, and TNF-alpha, and of the anti-inflammatory cytokines IL-10 and IL-1Ra. rabeta42 15-23 interferon gamma Homo sapiens 102-111 20508728-5 2010 alpha-galactosylceramide (alpha-GalCer)-activated type I NKT cells secrete both Th1 (e.g., IFN-gamma) and Th2 cytokines, affect the expression of costimulatory molecules in immune cells, and regulate the host immune system. alpha-galactosylceramide 0-24 interferon gamma Homo sapiens 91-100 22084597-2 2010 It is proposed that stress induced interleukin-18 (IL-18), via interferon-gamma (IFNy) and independently, increases indoleamine 2,3-dioxygenase (IDO) and subsequent quinolinic acid (QA) in microglia. Quinolinic Acid 165-180 interferon gamma Homo sapiens 63-79 22084597-2 2010 It is proposed that stress induced interleukin-18 (IL-18), via interferon-gamma (IFNy) and independently, increases indoleamine 2,3-dioxygenase (IDO) and subsequent quinolinic acid (QA) in microglia. Quinolinic Acid 182-184 interferon gamma Homo sapiens 63-79 19603308-6 2010 Bexarotene may be used alone or in association with interferon alfa, interferon gamma, extracorporeal photophoresis and PUVA. Bexarotene 0-10 interferon gamma Homo sapiens 69-85 19837722-2 2010 Previous studies have shown that methimazole (MMI) reduces MHC class-I expression and inhibits interferon-gamma (IFN-gamma or IFNG as listed in the MGI Database)-induced expression of the MHC class-II genes in TECs. Methimazole 33-44 interferon gamma Homo sapiens 95-111 19837722-2 2010 Previous studies have shown that methimazole (MMI) reduces MHC class-I expression and inhibits interferon-gamma (IFN-gamma or IFNG as listed in the MGI Database)-induced expression of the MHC class-II genes in TECs. Methimazole 33-44 interferon gamma Homo sapiens 113-122 19837722-2 2010 Previous studies have shown that methimazole (MMI) reduces MHC class-I expression and inhibits interferon-gamma (IFN-gamma or IFNG as listed in the MGI Database)-induced expression of the MHC class-II genes in TECs. Methimazole 33-44 interferon gamma Homo sapiens 126-130 19949076-5 2010 Despite this, C-glycoside caused a greater downstream activation of NK cells to produce IFN-gamma, accounting for its promotion of Th1 responses. C-glycoside 14-25 interferon gamma Homo sapiens 88-97 20936133-4 2010 This correlation was abolished when the cells were stimulated with TPA and ionomycin, which bypass TCR and introduce signals directly into the cells, but the production of IFN-gamma by SLE T cells remained abnormally elevated. Tetradecanoylphorbol Acetate 67-70 interferon gamma Homo sapiens 172-181 19952957-1 2010 In cancer patients undergoing immune therapy with lipopolysaccharides/interferon-gamma activated interleukin (IL)-12 secreting dendritic cells (DCs) we observed enhanced proliferative capacity of pyrophosphate-responsive peripheral blood (PB) gammadelta T-cells. diphosphoric acid 196-209 interferon gamma Homo sapiens 70-86 19950243-5 2010 However, one peptide with a mutation at the P5 position (methionine to cysteine) resulted in a significant enhanced binding to HLA A*0201 and also an increase in cell surface expression over the wild-type peptide but was unable to engage with the CD8 TCR and trigger IFNgamma production. Methionine 57-67 interferon gamma Homo sapiens 267-275 19950243-5 2010 However, one peptide with a mutation at the P5 position (methionine to cysteine) resulted in a significant enhanced binding to HLA A*0201 and also an increase in cell surface expression over the wild-type peptide but was unable to engage with the CD8 TCR and trigger IFNgamma production. Cysteine 71-79 interferon gamma Homo sapiens 267-275 20495288-0 2010 Interferon-gamma elevates nicotinamide N-methyltransferase activity and nicotinamide level in human glioma cells. Niacinamide 26-38 interferon gamma Homo sapiens 0-16 20495288-4 2010 We report herein that human glioma cells produce relatively large amounts of NNMT and that when these cells are cultured in the presence of interferon-gamma (IFN-gamma) their 1-methylnicotinamide levels increase. N(1)-methylnicotinamide 175-195 interferon gamma Homo sapiens 140-156 20495288-4 2010 We report herein that human glioma cells produce relatively large amounts of NNMT and that when these cells are cultured in the presence of interferon-gamma (IFN-gamma) their 1-methylnicotinamide levels increase. N(1)-methylnicotinamide 175-195 interferon gamma Homo sapiens 158-167 20495288-5 2010 To clarify the mechanisms by which IFN-gamma increases 1-methylnicotinamide levels in these cells, we measured NNMT activity and the levels of NNMT expression, nicotinamide and nicotinamide adenine dinucleotide (NAD(+)) in the presence and absence of IFN-gamma. N(1)-methylnicotinamide 55-75 interferon gamma Homo sapiens 35-44 20495288-5 2010 To clarify the mechanisms by which IFN-gamma increases 1-methylnicotinamide levels in these cells, we measured NNMT activity and the levels of NNMT expression, nicotinamide and nicotinamide adenine dinucleotide (NAD(+)) in the presence and absence of IFN-gamma. Niacinamide 63-75 interferon gamma Homo sapiens 35-44 20495288-5 2010 To clarify the mechanisms by which IFN-gamma increases 1-methylnicotinamide levels in these cells, we measured NNMT activity and the levels of NNMT expression, nicotinamide and nicotinamide adenine dinucleotide (NAD(+)) in the presence and absence of IFN-gamma. NAD 212-218 interferon gamma Homo sapiens 35-44 20495288-8 2010 Conversely, IFN-gamma significantly increased NNMT activity and the nicotinamide cellular concentration, while leaving NNMT expression and the NAD(+) cellular concentration unchanged. Niacinamide 68-80 interferon gamma Homo sapiens 12-21 20495288-9 2010 Therefore, the increase in the 1-methylnicotinamide level found when IFN-gamma is present in culture may be a consequence of increases in both the nicotinamide concentration and NNMT activity, whereas, 1-methylnicotinamide did not influence nicotinamide levels, NAD(+) levels, or cell viability per se. N(1)-methylnicotinamide 31-51 interferon gamma Homo sapiens 69-78 20495288-9 2010 Therefore, the increase in the 1-methylnicotinamide level found when IFN-gamma is present in culture may be a consequence of increases in both the nicotinamide concentration and NNMT activity, whereas, 1-methylnicotinamide did not influence nicotinamide levels, NAD(+) levels, or cell viability per se. Niacinamide 39-51 interferon gamma Homo sapiens 69-78 20495288-9 2010 Therefore, the increase in the 1-methylnicotinamide level found when IFN-gamma is present in culture may be a consequence of increases in both the nicotinamide concentration and NNMT activity, whereas, 1-methylnicotinamide did not influence nicotinamide levels, NAD(+) levels, or cell viability per se. Niacinamide 147-159 interferon gamma Homo sapiens 69-78 20495288-9 2010 Therefore, the increase in the 1-methylnicotinamide level found when IFN-gamma is present in culture may be a consequence of increases in both the nicotinamide concentration and NNMT activity, whereas, 1-methylnicotinamide did not influence nicotinamide levels, NAD(+) levels, or cell viability per se. NAD 262-268 interferon gamma Homo sapiens 69-78 21422704-7 2010 Vitamin E supplement resulted in decreased concentration of serum IL-2 and IFN-gamma, but increased concentration of serum IL-10. Vitamin E 0-9 interferon gamma Homo sapiens 75-84 19889762-1 2010 The Ebolavirus VP24 protein counteracts alpha/beta interferon (IFN-alpha/beta) and IFN-gamma signaling by blocking the nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1). Tyrosine 143-151 interferon gamma Homo sapiens 83-92 21403886-6 2010 This study demonstrated that salivary IFN-gamma, TNF-alpha, and sTNFR-2 can be detectable in ELP patients and decreased significantly after treatment with prednisone, which may reveal the possibility of using these disease-related biomarkers in diagnosis and monitoring. Prednisone 155-165 interferon gamma Homo sapiens 38-47 19957125-6 2010 The endogenous production of peroxynitrite in neuronal cells under oxygen-glucose deprivation (OGD) conditions has been visualized for the first time by utilizing HKGreen-1 probe, whilst the endogenous production of hypochlorous acid in macrophage cells upon stimulation with LPS, IFN-gamma, and PMA has been imaged by utilizing HKOCl-1 probe. Peroxynitrous Acid 29-42 interferon gamma Homo sapiens 281-290 19957125-6 2010 The endogenous production of peroxynitrite in neuronal cells under oxygen-glucose deprivation (OGD) conditions has been visualized for the first time by utilizing HKGreen-1 probe, whilst the endogenous production of hypochlorous acid in macrophage cells upon stimulation with LPS, IFN-gamma, and PMA has been imaged by utilizing HKOCl-1 probe. Hypochlorous Acid 216-233 interferon gamma Homo sapiens 281-290 20072880-5 2010 The immunogenicity of the liposomal peptide vaccines was further enhanced by incorporation of immunostimulatory CpG oligonucleotide sequences, shown by a strong increase of the frequency of IFN-gamma secreting cells that persisted at high levels for long periods of time. CPG-oligonucleotide 112-131 interferon gamma Homo sapiens 190-199 21173747-9 2010 CONCLUSIONS: Increased production of IL-1beta a IL-6 cytokines in reaction to titanium and increased production of TNF-alpha and IFN-gamma cytokines in reaction to mercury, which is very often present in the form of amalgam in the oral cavity of persons in need of implant therapy, can play an important role in immune reactions during implant healing process. Mercury 164-171 interferon gamma Homo sapiens 129-138 21246917-8 2010 Significantly elevated serum IFN-g were noticed in patients with AU type (11.81 +/- 1.11 pg/mL), expecialy those suffering from AT (12.30 +/- 0.93 pg/mL), compared with both patients with AUl (10.20 +/- 0.59 pg/mL) and patients with AM clinical type (10.21 +/- 0.78 pg/mL). Gold 65-67 interferon gamma Homo sapiens 29-34 21173747-2 2010 DESIGN: The aim of our study was to determine if there is a difference between metal influenced IL-1beta, IL-4, IL-6, TNF-alpha and IFN-gamma cytokines production in patients with successfully healed implants compared to those, whose implant therapy was unsuccessful. Metals 79-84 interferon gamma Homo sapiens 132-141 21173747-7 2010 TNF-alpha and IFN-gamma levels were also significantly increased after the stimulation with titanium. Titanium 92-100 interferon gamma Homo sapiens 14-23 27534055-3 2010 An immunological study of the patients receiving AFL ascertained the higher specific antigen-induced production of interferon-gamma (IFN-gamma) in the whole blood samples in vitro; immunophenotyping showed a higher percentage of circulating gamma/delta T lymphocytes and a lower proportion of a subpopulation of IFN-gamma-producing gamma/delta T lymphocytes, including in vitro antigen-induced ones. aflatoxicol 49-52 interferon gamma Homo sapiens 115-131 21427975-5 2010 The response to IFNgamma differed in the tested cell lines: cell growth was inhibited in both A431 and HeLa cells, but not in HEK293 cells, as shown by cell counts and MTT. monooxyethylene trimethylolpropane tristearate 168-171 interferon gamma Homo sapiens 16-24 27534055-3 2010 An immunological study of the patients receiving AFL ascertained the higher specific antigen-induced production of interferon-gamma (IFN-gamma) in the whole blood samples in vitro; immunophenotyping showed a higher percentage of circulating gamma/delta T lymphocytes and a lower proportion of a subpopulation of IFN-gamma-producing gamma/delta T lymphocytes, including in vitro antigen-induced ones. aflatoxicol 49-52 interferon gamma Homo sapiens 133-142 27534055-3 2010 An immunological study of the patients receiving AFL ascertained the higher specific antigen-induced production of interferon-gamma (IFN-gamma) in the whole blood samples in vitro; immunophenotyping showed a higher percentage of circulating gamma/delta T lymphocytes and a lower proportion of a subpopulation of IFN-gamma-producing gamma/delta T lymphocytes, including in vitro antigen-induced ones. aflatoxicol 49-52 interferon gamma Homo sapiens 312-321 21322819-6 2010 The use of cycloferon as immune modulator in the complex therapy led to the increase in the interferon gamma level and the decrease of general clinical manifestations during tick-borne encephalitis and mixed infection. 10-carboxymethyl-9-acridanone 11-21 interferon gamma Homo sapiens 92-108 20029331-10 2009 Cytokine analysis demonstrated that bortezomib could not only suppress rapamycin-permissive interleukin (IL)-6 production, but also production of interferon (IFN)-gamma, IL-4, and IL-10. Bortezomib 36-46 interferon gamma Homo sapiens 146-168 19951991-4 2009 The acquisition of folate uptake ability by macrophages is promoted by M-CSF, maintained by IL-4, prevented by GM-CSF, and reduced by IFNgamma, indicating a link between FRbeta expression and M2 polarization. Folic Acid 19-25 interferon gamma Homo sapiens 134-142 20559261-6 2010 The use of cycloferon as immune modulator in the complex therapy led to the increase in the interferon gamma level and the decrease of general clinical manifestations during tick-borne encephalitis and mixed infection. 10-carboxymethyl-9-acridanone 11-21 interferon gamma Homo sapiens 92-108 19933854-3 2009 Priming of influenza hemagglutinin (HA)-specific naive CD4 T cells with HA peptide and the TLR2 agonist Pam3CysK in vivo resulted in a high frequency of activated HA-specific CD4 T cells that predominantly produced IL-2 and IL-17, whereas priming with HA peptide and the TLR4 agonist LPS yielded a lower frequency of HA-specific CD4 T cells and predominant IFN-gamma producers. pam3cysk 104-112 interferon gamma Homo sapiens 357-366 19923445-3 2009 Most importantly, GMSCs were capable of immunomodulatory functions, specifically suppressed peripheral blood lymphocyte proliferation, induced expression of a wide panel of immunosuppressive factors including IL-10, IDO, inducible NO synthase (iNOS), and cyclooxygenase 2 (COX-2) in response to the inflammatory cytokine, IFN-gamma. gmscs 18-23 interferon gamma Homo sapiens 322-331 19805617-4 2009 Our results show that in vitro treatment of PCMCs with interferon-gamma and interleukin-4 induced surface expression of mature major histocompatibility complex class II molecules and CD86. pcmcs 44-49 interferon gamma Homo sapiens 55-71 20154512-7 2009 The TT +874 IFN-gamma and GG -174 IL-6 high producer-genotypes and the AA IL-10 low producergenotype were indeed more frequent in the ACP group (IFN-gamma: p=0.000 and IL-6: p=0.004). acp 134-137 interferon gamma Homo sapiens 12-38 20154512-7 2009 The TT +874 IFN-gamma and GG -174 IL-6 high producer-genotypes and the AA IL-10 low producergenotype were indeed more frequent in the ACP group (IFN-gamma: p=0.000 and IL-6: p=0.004). acp 134-137 interferon gamma Homo sapiens 12-21 19935876-7 2009 Site-specific mutations of the EBS diminished the promoter activity stimulated by IFN-gamma, although the IFN-gamma responsive element (pIgammaRE), which binds Stat1, was intact. ethylbenzene 31-34 interferon gamma Homo sapiens 82-91 19935876-8 2009 Stimulation of the transcriptional activity following IFN-gamma treatment was significantly reduced when both EBSs were inactivated. ebss 110-114 interferon gamma Homo sapiens 54-63 19755523-9 2009 Treatment of TFC with TZDs dose-dependently suppressed IFNgamma+TNFalpha-induced CXCL10 release, while TZDs stimulated CXCL10 secretion in PTCs. Thiazolidinediones 22-26 interferon gamma Homo sapiens 55-63 18691343-2 2009 Intracellular interleukin-4 (Th2 cytokine) and interferon-gamma (Th1 cytokine) production was assessed in CD4+ T lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin using flow cytometry. Tetradecanoylphorbol Acetate 138-169 interferon gamma Homo sapiens 47-63 18691343-2 2009 Intracellular interleukin-4 (Th2 cytokine) and interferon-gamma (Th1 cytokine) production was assessed in CD4+ T lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin using flow cytometry. Ionomycin 174-183 interferon gamma Homo sapiens 47-63 19009233-6 2009 In addition, trichodimerol blocked IFN-gamma, IL-6 and IL-4 induced activation of Stat1, Stat3 and Stat6 transcription factors by inhibiting serine and tyrosine phosphorylation. trichodimerol 13-26 interferon gamma Homo sapiens 35-44 19009233-6 2009 In addition, trichodimerol blocked IFN-gamma, IL-6 and IL-4 induced activation of Stat1, Stat3 and Stat6 transcription factors by inhibiting serine and tyrosine phosphorylation. Serine 141-147 interferon gamma Homo sapiens 35-44 19009233-6 2009 In addition, trichodimerol blocked IFN-gamma, IL-6 and IL-4 induced activation of Stat1, Stat3 and Stat6 transcription factors by inhibiting serine and tyrosine phosphorylation. Tyrosine 152-160 interferon gamma Homo sapiens 35-44 19762521-7 2009 Although both 12% and 15% O(2) ME increased NK count, perforin/granzyme B/interferon-gamma levels, NK-NPC binding, and NK-induced CD95 expression and apoptosis of NPC, only 12% O(2) ME increased percentages of the NKs with CD57(+)/CD28(-)/KLRG1(+) in blood. methionylglutamic acid 31-33 interferon gamma Homo sapiens 74-90 19762521-7 2009 Although both 12% and 15% O(2) ME increased NK count, perforin/granzyme B/interferon-gamma levels, NK-NPC binding, and NK-induced CD95 expression and apoptosis of NPC, only 12% O(2) ME increased percentages of the NKs with CD57(+)/CD28(-)/KLRG1(+) in blood. o(2) me 26-33 interferon gamma Homo sapiens 74-90 19762521-4 2009 The results demonstrated that 21% O(2) HE, but not ME, increased cellular perforin/granzyme B/interferon-gamma levels in NKs and interferon-gamma concentration in NK-NPC coincubation, and also promoted capacity of NKs to bind to NPCs and NK-induced CD95 expression and phosphatidylserine exposure of NPCs. Helium 39-41 interferon gamma Homo sapiens 94-110 19762521-4 2009 The results demonstrated that 21% O(2) HE, but not ME, increased cellular perforin/granzyme B/interferon-gamma levels in NKs and interferon-gamma concentration in NK-NPC coincubation, and also promoted capacity of NKs to bind to NPCs and NK-induced CD95 expression and phosphatidylserine exposure of NPCs. Helium 39-41 interferon gamma Homo sapiens 129-145 19762521-7 2009 Although both 12% and 15% O(2) ME increased NK count, perforin/granzyme B/interferon-gamma levels, NK-NPC binding, and NK-induced CD95 expression and apoptosis of NPC, only 12% O(2) ME increased percentages of the NKs with CD57(+)/CD28(-)/KLRG1(+) in blood. Oxygen 26-30 interferon gamma Homo sapiens 74-90 19890026-6 2009 RESULTS: Cellular proliferation (P = 0.0009) and secretion of interferon-gamma (P < 0.0001) in response to 21OH was significantly higher in patients compared to healthy controls and associated with the presence of 21OH autoantibodies (P = 0.0052). 21oh 110-114 interferon gamma Homo sapiens 62-78 19502771-8 2009 Moreover, norepinephrine levels were inversely correlated (r=-0.591; p<0.001) with IFN-gamma expression, a typical Th1 cytokine. Norepinephrine 10-24 interferon gamma Homo sapiens 86-95 19890026-6 2009 RESULTS: Cellular proliferation (P = 0.0009) and secretion of interferon-gamma (P < 0.0001) in response to 21OH was significantly higher in patients compared to healthy controls and associated with the presence of 21OH autoantibodies (P = 0.0052). 21oh 217-221 interferon gamma Homo sapiens 62-78 19890026-7 2009 Furthermore, the 21OH-specific production of interferon-gamma was enhanced in the presence of 21OH autoantibodies. 21oh 17-21 interferon gamma Homo sapiens 45-61 19890026-7 2009 Furthermore, the 21OH-specific production of interferon-gamma was enhanced in the presence of 21OH autoantibodies. 21oh 94-98 interferon gamma Homo sapiens 45-61 19874177-4 2009 Greater increases in interferon gamma (IFN-gamma) and skin test responses to PPD were seen at week 24 and 12 in participants with TB-IRIS (P< or = .04), respectively. tb-iris 130-137 interferon gamma Homo sapiens 21-48 19522774-3 2009 Neopterin is an immunological marker of cellular immune activation, which is secreted by monocytes/macrophages as a result of interferon-gamma (IFN-gamma) secretion by activated T lymphocytes. Neopterin 0-9 interferon gamma Homo sapiens 126-142 19915058-6 2009 Surprisingly, DC.Tbets were impaired in their production of IL-12 family member cytokines (IL-12p70, IL-23, and IL-27) when compared with control DC, and the capacity of DC.Tbet to preferentially prime type 1 T cell responses was only minimally inhibited by cytokine (IL-12p70, IL-23, IFN-gamma) neutralization or receptor (IL-12Rbeta2, IL-27R) blockade during T cell priming. tbets 17-22 interferon gamma Homo sapiens 285-294 19522774-3 2009 Neopterin is an immunological marker of cellular immune activation, which is secreted by monocytes/macrophages as a result of interferon-gamma (IFN-gamma) secretion by activated T lymphocytes. Neopterin 0-9 interferon gamma Homo sapiens 144-153 19915058-6 2009 Surprisingly, DC.Tbets were impaired in their production of IL-12 family member cytokines (IL-12p70, IL-23, and IL-27) when compared with control DC, and the capacity of DC.Tbet to preferentially prime type 1 T cell responses was only minimally inhibited by cytokine (IL-12p70, IL-23, IFN-gamma) neutralization or receptor (IL-12Rbeta2, IL-27R) blockade during T cell priming. tbet 17-21 interferon gamma Homo sapiens 285-294 19915063-0 2009 Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner. Epoprostenol 0-12 interferon gamma Homo sapiens 22-31 20030937-0 2009 [Effect of 1,4-benzoquinone on growth of hematopoietic myeloid progenitor cells with IFN-gamma different genotypes]. quinone 11-27 interferon gamma Homo sapiens 85-94 19915063-4 2009 Because activated monocytes are critical sources of MCP-1 and other cytokines in cardiovascular inflammation, we examined the effects of iloprost on IFN-gamma- and IL-6-stimulated cytokine production in human monocytes. Iloprost 137-145 interferon gamma Homo sapiens 149-158 19915063-5 2009 We found that iloprost inhibited IFN-gamma- and IL-6-induced MCP-1, IL-8, RANTES, and TNF-alpha production in monocytes, indicating wide-ranging anti-inflammatory action. Iloprost 14-22 interferon gamma Homo sapiens 33-42 18571695-2 2009 Since increased interferon-gamma (INF-gamma) has been associated with RP, we also compared the INF-gamma production in pSS patients with or without RP. pss 119-122 interferon gamma Homo sapiens 95-104 20030937-1 2009 This study was aimed to investigate the effect of 1,4-benzoquinone (1,4-BQ) on growth of myeloid progenitor cells with IFN-gamma different genotypes and to compare its differences. quinone 50-66 interferon gamma Homo sapiens 119-128 20030937-1 2009 This study was aimed to investigate the effect of 1,4-benzoquinone (1,4-BQ) on growth of myeloid progenitor cells with IFN-gamma different genotypes and to compare its differences. quinone 68-74 interferon gamma Homo sapiens 119-128 19919129-0 2009 FIP-fve stimulates interferon-gamma production via modulation of calcium release and PKC-alpha activation. Calcium 65-72 interferon gamma Homo sapiens 19-35 19919129-4 2009 ELISA, RT-PCR and Western blot assays demonstrated significant increases in the production and mRNA expression of IFN-gamma and protein kinase C-alpha (PKC-alpha) activation in activated PBMCs, which were abolished by EGTA, nifedipine and GO6976. Egtazic Acid 218-222 interferon gamma Homo sapiens 114-123 19919129-4 2009 ELISA, RT-PCR and Western blot assays demonstrated significant increases in the production and mRNA expression of IFN-gamma and protein kinase C-alpha (PKC-alpha) activation in activated PBMCs, which were abolished by EGTA, nifedipine and GO6976. Nifedipine 224-234 interferon gamma Homo sapiens 114-123 19919129-4 2009 ELISA, RT-PCR and Western blot assays demonstrated significant increases in the production and mRNA expression of IFN-gamma and protein kinase C-alpha (PKC-alpha) activation in activated PBMCs, which were abolished by EGTA, nifedipine and GO6976. Go 6976 239-245 interferon gamma Homo sapiens 114-123 19936064-8 2009 In addition, we relate defective IFN-gamma and TNF-alpha production in response to FK866 to impaired Sirt6 activity. N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 83-88 interferon gamma Homo sapiens 33-42 19948042-0 2009 Evaluation of the tuberculin skin test and the interferon-gamma release assay for TB screening in French healthcare workers. Terbium 82-84 interferon gamma Homo sapiens 47-63 19762486-3 2009 Stimulation of CD56+ cells containing both DCs and abundant gammadelta T cells with zoledronate and interleukin-2 (IL-2) resulted in the rapid expansion of gammadelta T cells as well as in IFN-gamma, TNF-alpha, and IL-1beta but not in IL-4, IL-10, or IL-17 production. Zoledronic Acid 84-95 interferon gamma Homo sapiens 189-198 19846878-0 2009 Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation. Adenosine 0-9 interferon gamma Homo sapiens 17-26 19846878-0 2009 Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation. Serine 63-69 interferon gamma Homo sapiens 17-26 19846878-2 2009 IFN-gamma signaling induces phosphorylation of two STAT1 residues: Tyr(701) (Y701), which facilitates dimerization, nuclear translocation, and DNA binding; and Ser(727) (S727), which enables maximal STAT1 transcription activity. Tyrosine 67-70 interferon gamma Homo sapiens 0-9 19846878-2 2009 IFN-gamma signaling induces phosphorylation of two STAT1 residues: Tyr(701) (Y701), which facilitates dimerization, nuclear translocation, and DNA binding; and Ser(727) (S727), which enables maximal STAT1 transcription activity. Serine 160-163 interferon gamma Homo sapiens 0-9 19846878-4 2009 We hypothesized that adenosine achieves these protective effects by interrupting IFN-gamma signaling in activated macrophages. Adenosine 21-30 interferon gamma Homo sapiens 81-90 19846878-6 2009 We show that adenosine inhibits IFN-gamma-induced STAT1 S727 phosphorylation by >30% and phosphoserine-mediated transcriptional activity by 58% but has no effect on phosphorylation of Y701 or receptor-associated JAK tyrosine kinases. Adenosine 13-22 interferon gamma Homo sapiens 32-41 19846878-10 2009 Because STAT1 plays a key role in IFN-gamma-induced inflammation and foam cell transformation, a better understanding of the mechanisms underlying STAT1 deactivation by adenosine may improve preventative and therapeutic approaches to vascular disease. Adenosine 169-178 interferon gamma Homo sapiens 34-43 19906293-9 2009 CP-870,893-activated B cells induced T cell proliferation and T cell secretion of effector cytokines including IFN-gamma and IL-2. cp-870 0-6 interferon gamma Homo sapiens 111-120 19776010-5 2009 IFNgamma induced sustained loss of insulin-stimulated glucose uptake in human adipocytes, coincident with reduced Akt phosphorylation and down-regulation of the insulin receptor, insulin receptor substrate-1, and GLUT4. Glucose 54-61 interferon gamma Homo sapiens 0-8 19776010-6 2009 Loss of adipocyte triglyceride storage was observed with IFNgamma co-incident with reduced expression of peroxisome proliferator-activated receptor gamma, adiponectin, perilipin, fatty acid synthase, and lipoprotein lipase. Triglycerides 18-30 interferon gamma Homo sapiens 57-65 19821527-7 2009 CD11b-deficient NK cells stimulated with or without the TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] exhibited more potent cytotoxicity, and higher production of IFN-gamma and granzyme B. Poly C 81-99 interferon gamma Homo sapiens 173-182 19660462-9 2009 A correlation was present between serum norfloxacins concentrations and tumor necrosis factor-alpha (r = -0.68; P < .001), interferon-gamma (r = -0.66; P < .001), interleukin-12 (r = -0.66; P < .001), and nitric oxide (r = -0.68; P < .001). Norfloxacin 40-52 interferon gamma Homo sapiens 126-142 19843934-6 2009 Both CD8(+) and CD4(+) T cells proliferated well in the presence of A2AR agonists, but their IFN-gamma-producing activities were susceptible to inhibition by cAMP-elevating A2AR. Cyclic AMP 158-162 interferon gamma Homo sapiens 93-102 19665237-4 2009 The expression of C4 by HTR8/SVneo trophoblast cells and of C3 and C4 by CTBs was up-regulated by IFNgamma, while IL-1alpha and TNFalpha had no effect on the expression of complement components. bromebric acid 73-77 interferon gamma Homo sapiens 98-106 19712765-3 2009 Tet+ CD8 cells mainly had an effector phenotype (CD45RA-/+ CCR7- and CD28- and Perf+/-) and maintained IFN-gamma release throughout follow-up. tetramethylenedisulfotetramine 0-3 interferon gamma Homo sapiens 103-112 19679214-4 2009 Our results show that Fluzone combined with lipid A plus an emulsion effectively leads to greater vaccine-specific IgG2a and IgG titers, enhances hemagglutination-inhibition titers and induces Type 1 cytokine responses (IFN-gamma and IL-2) to each of the Fluzone components. Lipid A 44-51 interferon gamma Homo sapiens 220-229 19855245-14 2009 Moreover, treatment with TAK-779 (a) decreased alloantigen-specific T-lymphocyte proliferation and number of IFN-gamma producing cells and (b) increased HO-1 gene transcript level in the allografts. TAK 779 25-32 interferon gamma Homo sapiens 109-118 19855245-17 2009 The beneficial effects of TAK-779 may be because of (a) reduction in CCR5 and CXCR3 T-lymphocyte subset infiltration into the graft, (b) attenuation of alloantigen-specific T-lymphocyte proliferative response and IFN-gamma production, and (c) induction of HO-1 gene. TAK 779 26-33 interferon gamma Homo sapiens 213-222 19646959-6 2009 Hypoxia (1% O(2)) and the iron chelator deferoxamine (DFX), a hypoxia mimetic, increased the levels of CXCR4 mRNA in A172 and T98G cells, and treatment with IFNgamma inhibited the expression of CXCR4 mRNA. Iron 26-30 interferon gamma Homo sapiens 157-165 19646959-6 2009 Hypoxia (1% O(2)) and the iron chelator deferoxamine (DFX), a hypoxia mimetic, increased the levels of CXCR4 mRNA in A172 and T98G cells, and treatment with IFNgamma inhibited the expression of CXCR4 mRNA. Deferoxamine 40-52 interferon gamma Homo sapiens 157-165 19607809-3 2009 Both OA-NO(2) and LNO(2) prevented TNFalpha-stimulated release of the cytokines, IL-6, IL-8, IL-12/p40, IFNgamma, MCP-1, and IP-10, and inhibited NF-kappaB activation. L-Leucyl-Hydroxylamine 18-21 interferon gamma Homo sapiens 104-112 19646959-6 2009 Hypoxia (1% O(2)) and the iron chelator deferoxamine (DFX), a hypoxia mimetic, increased the levels of CXCR4 mRNA in A172 and T98G cells, and treatment with IFNgamma inhibited the expression of CXCR4 mRNA. Deferoxamine 54-57 interferon gamma Homo sapiens 157-165 19646959-8 2009 The results of a luciferase reporter assay using a heterologous promoter construct containing the HRE sequence revealed that IFNgamma suppressed the hypoxia- and DFX-induced reporter activities. Deferoxamine 162-165 interferon gamma Homo sapiens 125-133 18821062-4 2009 We also demonstrate that Poly E blocked signal transducers and activators of transcription (STAT) signaling by suppressing interferon-gamma (IFN-gamma)-induced gene transcription via IFN-gamma-activating sequence (GAS) elements and downstream STAT3 activation by inhibiting STAT1 and STAT3 dimerization in MDA-MB231 cells. polyphenon E 25-31 interferon gamma Homo sapiens 141-150 19747638-7 2009 Similarly, patients carrying 2 IFNG 13-CA-repeat alleles (homozygotes) had more frequent CMV reactivation (0.50 vs 0.26; P = .039) and a higher CMV load (4111 +/- 1699 vs 950+/-591 CMV copies/10(5) cells; P = .041) compared with those with other IFNG microsatellite allele constellations. 13-ca 36-41 interferon gamma Homo sapiens 31-35 19747638-7 2009 Similarly, patients carrying 2 IFNG 13-CA-repeat alleles (homozygotes) had more frequent CMV reactivation (0.50 vs 0.26; P = .039) and a higher CMV load (4111 +/- 1699 vs 950+/-591 CMV copies/10(5) cells; P = .041) compared with those with other IFNG microsatellite allele constellations. 13-ca 36-41 interferon gamma Homo sapiens 246-250 18821062-4 2009 We also demonstrate that Poly E blocked signal transducers and activators of transcription (STAT) signaling by suppressing interferon-gamma (IFN-gamma)-induced gene transcription via IFN-gamma-activating sequence (GAS) elements and downstream STAT3 activation by inhibiting STAT1 and STAT3 dimerization in MDA-MB231 cells. polyphenon E 25-31 interferon gamma Homo sapiens 183-192 19728309-0 2009 PolyI:C plus IL-2 or IL-12 induce IFN-gamma production by human NK cells via autocrine IFN-beta. Poly I-C 0-7 interferon gamma Homo sapiens 34-43 19737230-3 2009 We used recombinant human IFN-gamma to stimulate adherent monocyte-derived macrophages from three groups of people: patients with active tuberculosis (TBP), their healthy household contacts (HHC) and healthy uninfected controls from the community (CC). tributyl phosphate 151-154 interferon gamma Homo sapiens 26-35 19737230-5 2009 After IFN-gamma treatment, macrophages of healthy individuals (HHC and CC) controlled M. tuberculosis growth and produced mainly nitric oxide (NO) and interleukin (IL)-12p70, whereas TBP macrophages did not kill M. tuberculosis. Nitric Oxide 129-141 interferon gamma Homo sapiens 6-15 19637229-1 2009 In mammals, the regulation of local tryptophan concentrations by the IFN-gamma-i inducible enzyme IDO is a prominent antimicrobial and immunoregulatory effector mechanism. Tryptophan 36-46 interferon gamma Homo sapiens 69-78 19728309-4 2009 Neutralizing anti-IFNAR1 or anti-IFN-beta Ab prevented the production of IFN-gamma induced by polyI:C plus IL-2/IL-12. Poly I-C 94-101 interferon gamma Homo sapiens 73-82 19596836-8 2009 Re-expression of TSC2 or treatment with rapamycin inhibited IFN-gamma-induced STAT3 phosphorylation and synergized with IFN-gamma in inhibiting TSC2-null and LAMD cell proliferation. Sirolimus 40-49 interferon gamma Homo sapiens 60-69 19728309-6 2009 The ability of polyI:C plus IL-12 to induce IFN-gamma production was related to an increase of TLR3, Mda5 and IFNAR expression and by an increase of STAT1 and STAT4 phosphorylation. Poly I-C 15-22 interferon gamma Homo sapiens 44-53 19728309-7 2009 Collectively, these data demonstrate that NK cells, in response to polyI:C plus IL-2/IL-12, produce IFN-beta that induce, in an autocrine manner, the production of IFN-gamma and thereby highlight that NK cells may control the outcome of protective or injurious immune responses through type I IFN secretion. Poly I-C 67-74 interferon gamma Homo sapiens 164-173 20157607-0 2009 Nitric Oxide Synthesis is Modulated by 1,25-Dihydroxyvitamin D3 and Interferon-gamma in Human Macrophages after Mycobacterial Infection. Nitric Oxide 0-12 interferon gamma Homo sapiens 68-84 19692538-10 2009 Neutralizing IL-1R or IFNgamma reduced TEC-induced apoptosis of DP thymic cells. Turpentine 39-42 interferon gamma Homo sapiens 22-30 19596836-8 2009 Re-expression of TSC2 or treatment with rapamycin inhibited IFN-gamma-induced STAT3 phosphorylation and synergized with IFN-gamma in inhibiting TSC2-null and LAMD cell proliferation. Sirolimus 40-49 interferon gamma Homo sapiens 120-129 19786211-9 2009 Oral steroid-naive CRS patients with biofilm demonstrated a local T(H)1 inflammatory response with significantly elevated levels of interferon-gamma (INF-gamma), granulocyte colony-stimulating factor, macrophage inflammatory protein-1 beta, and neutrophils in the sinonasal mucosa. Steroids 5-12 interferon gamma Homo sapiens 132-148 19614863-0 2009 Expression of IFN-gamma before and after treatment of oral lichen planus with 0.1% fluocinolone acetonide in orabase. Fluocinolone Acetonide 83-105 interferon gamma Homo sapiens 14-23 19614863-2 2009 The purpose of this study was to investigate the effect of 0.1% fluocinolone acetonide in orabase (FAO) on the in situ expression of IFN-gamma in patients with OLP. Fluocinolone Acetonide 64-86 interferon gamma Homo sapiens 133-142 19614863-2 2009 The purpose of this study was to investigate the effect of 0.1% fluocinolone acetonide in orabase (FAO) on the in situ expression of IFN-gamma in patients with OLP. Orabase 90-97 interferon gamma Homo sapiens 133-142 19614863-2 2009 The purpose of this study was to investigate the effect of 0.1% fluocinolone acetonide in orabase (FAO) on the in situ expression of IFN-gamma in patients with OLP. fao 99-102 interferon gamma Homo sapiens 133-142 19934811-13 2009 IFNgamma-immunoreactivity also highly correlated with reported reduction of pain 3-months after the epidural steroid injection. Steroids 109-116 interferon gamma Homo sapiens 0-8 19934811-15 2009 The IFNgamma-immunoreactivity in repeat lavage samples decreased to trace residual concentrations in patients who reported pain relief from the steroid injection. Steroids 144-151 interferon gamma Homo sapiens 4-12 19934811-16 2009 CONCLUSION: The presence of epidural IFNgamma-immunoreactivity corresponding to >10 pg/mL predicted significant pain relief after epidural steroid injection with >95% accuracy. Steroids 142-149 interferon gamma Homo sapiens 37-45 19295495-8 2009 LPS/IFN-gamma downregulated the phosphorylation of multiple Akt substrates, including the proline-rich Akt substrate 40, while enhancing the phosphorylation of raptor on a 5"-AMP-activated kinase (AMPK)-regulated site. Proline 90-97 interferon gamma Homo sapiens 4-13 19934811-17 2009 These results suggest that IFNgamma may be part of a biochemical cascade triggering pain in sciatica; IFNgamma-immunoreactivity may aid as a biomarker for predicting the response to steroid therapy and/or surgical intervention, and may serve as a future therapeutic target. Steroids 182-189 interferon gamma Homo sapiens 102-110 19947470-2 2009 With the use of photochemical fixed method, TNF-alpha/IFN-gamma were co-immobilized on a 24-well polystyrene culture plate. Polystyrenes 97-108 interferon gamma Homo sapiens 54-63 19857752-11 2009 CONCLUSION: CsA significantly impaired the function of CD4+CD25+ Treg cells by inducing interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) secretion. Cyclosporine 12-15 interferon gamma Homo sapiens 113-129 19857752-11 2009 CONCLUSION: CsA significantly impaired the function of CD4+CD25+ Treg cells by inducing interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) secretion. Cyclosporine 12-15 interferon gamma Homo sapiens 131-140 19849935-8 2009 The serum concentrations of IL-2, IL-4, IL-10 and IFN-gamma in the AITP and the CITP groups were significantly higher than those in the control group (p<0.05). aitp 67-71 interferon gamma Homo sapiens 50-59 19954658-7 2009 (3) On exposure to RAPA, the levels of p-mTOR, p-S6 and IFN-gamma in T cells in refractory/relapsed AA patients were significantly lower than those before the exposure (all P < 0.05). Sirolimus 19-23 interferon gamma Homo sapiens 56-65 20652105-7 2009 In addition, ZnO nanoparticles induce the production of the proinflammatory cytokines, IFN-gamma, TNF-alpha, and IL-12, at concentrations below those causing appreciable cell death. Zinc Oxide 13-16 interferon gamma Homo sapiens 87-96 19857741-9 2009 As in other granulomatous disease-induced HCa, including fungal infections, it is likely that endogenous extrarenal production of 1-alpha-hydroxylase by activated macrophages and by interferon-gamma involved in granuloma formation results in increased conversion from 25-(OH) vitamin D to 1,25-(OH)2 vitamin D and, consequently, in transient HCa and suppression of PTH secretion. 25-(oh) vitamin d 268-285 interferon gamma Homo sapiens 182-198 19857741-9 2009 As in other granulomatous disease-induced HCa, including fungal infections, it is likely that endogenous extrarenal production of 1-alpha-hydroxylase by activated macrophages and by interferon-gamma involved in granuloma formation results in increased conversion from 25-(OH) vitamin D to 1,25-(OH)2 vitamin D and, consequently, in transient HCa and suppression of PTH secretion. 1,25-(oh)2 vitamin d 289-309 interferon gamma Homo sapiens 182-198 19759901-8 2009 MS-275- and to a lesser extent Trichostatin A- and SAHA-treated Raji cells significantly up regulated T lymphocytes proliferation which was reduced by about 50% by a 4-1BB blocking recombinant protein, while MS-275- but neither Trichostatin A- nor SAHA-treated cells up-regulated IFNgamma secretion by T lymphocytes. entinostat 0-6 interferon gamma Homo sapiens 280-288 19759901-8 2009 MS-275- and to a lesser extent Trichostatin A- and SAHA-treated Raji cells significantly up regulated T lymphocytes proliferation which was reduced by about 50% by a 4-1BB blocking recombinant protein, while MS-275- but neither Trichostatin A- nor SAHA-treated cells up-regulated IFNgamma secretion by T lymphocytes. Vorinostat 51-55 interferon gamma Homo sapiens 280-288 19576177-2 2009 In this study, we examined the effect of 1,2,3,4,6-penta-O-galloyl-beta-d-glucose (PGG), isolated from the barks of Juglans mandshurica, on TNF-alpha/IFN-gamma induced CCL17 expression in the human keratinocyte cell line HaCaT. beta-penta-O-galloyl-glucose 41-81 interferon gamma Homo sapiens 150-159 19576177-4 2009 PGG significantly inhibited TNF-alpha/IFN-gamma-induced NF-kappaB activation as well as STAT1 activation. beta-penta-O-galloyl-glucose 0-3 interferon gamma Homo sapiens 38-47 19576177-2 2009 In this study, we examined the effect of 1,2,3,4,6-penta-O-galloyl-beta-d-glucose (PGG), isolated from the barks of Juglans mandshurica, on TNF-alpha/IFN-gamma induced CCL17 expression in the human keratinocyte cell line HaCaT. beta-penta-O-galloyl-glucose 83-86 interferon gamma Homo sapiens 150-159 19576177-5 2009 Furthermore, pretreatment with PGG resulted in significant reduction in expression of CXCL9, 10, and 11 in the HaCaT cells treated with IFN-gamma. beta-penta-O-galloyl-glucose 31-34 interferon gamma Homo sapiens 136-145 19576177-6 2009 These results suggest that PGG may exert anti-inflammatory responses by suppressing TNF-alpha and/or IFN-gamma-induced activation of NF-kappaB and STAT1 in the keratinocytes and might be a useful tool in therapy of skin inflammatory diseases. beta-penta-O-galloyl-glucose 27-30 interferon gamma Homo sapiens 101-110 19576177-3 2009 Pretreatment of HaCaT cells with PGG suppressed TNF-alpha/IFN-gamma-induced protein and mRNA expression of CCL17. beta-penta-O-galloyl-glucose 33-36 interferon gamma Homo sapiens 58-67 19191908-5 2009 The effect of these CLIP-derived high-affinity peptides on beryllium presentation was determined by measuring interferon-gamma (IFN-gamma) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium-hypersensitive subjects. Beryllium 59-68 interferon gamma Homo sapiens 110-126 19561642-7 2009 Pretreatment of MM cells with interferon-gamma upregulated Fas/CD95 and caspase-8, and potentiated resveratrol-induced apoptosis. ammonium ferrous sulfate 59-62 interferon gamma Homo sapiens 30-46 19561642-7 2009 Pretreatment of MM cells with interferon-gamma upregulated Fas/CD95 and caspase-8, and potentiated resveratrol-induced apoptosis. Resveratrol 99-110 interferon gamma Homo sapiens 30-46 19597472-4 2009 HDACI, for example, valproic acid (VA), suberoylanilide hydroxamic acid (SAHA) and MS-275, cooperate with IFN-gamma to upregulate caspase-8 in cancer cells lacking caspase-8, thereby restoring sensitivity to TRAIL-induced apoptosis. Valproic Acid 35-37 interferon gamma Homo sapiens 106-115 19597472-4 2009 HDACI, for example, valproic acid (VA), suberoylanilide hydroxamic acid (SAHA) and MS-275, cooperate with IFN-gamma to upregulate caspase-8 in cancer cells lacking caspase-8, thereby restoring sensitivity to TRAIL-induced apoptosis. Vorinostat 40-71 interferon gamma Homo sapiens 106-115 19597472-4 2009 HDACI, for example, valproic acid (VA), suberoylanilide hydroxamic acid (SAHA) and MS-275, cooperate with IFN-gamma to upregulate caspase-8 in cancer cells lacking caspase-8, thereby restoring sensitivity to TRAIL-induced apoptosis. Vorinostat 73-77 interferon gamma Homo sapiens 106-115 19574556-6 2009 Inhibition of PHD activity with dimethyloxallyl glycine or desferroxamine reduced IFNg-dependent responses in these same cells. dimethyloxallyl glycine 32-55 interferon gamma Homo sapiens 82-86 19574556-6 2009 Inhibition of PHD activity with dimethyloxallyl glycine or desferroxamine reduced IFNg-dependent responses in these same cells. Deferoxamine 59-73 interferon gamma Homo sapiens 82-86 19191908-5 2009 The effect of these CLIP-derived high-affinity peptides on beryllium presentation was determined by measuring interferon-gamma (IFN-gamma) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium-hypersensitive subjects. Beryllium 59-68 interferon gamma Homo sapiens 128-137 19191908-5 2009 The effect of these CLIP-derived high-affinity peptides on beryllium presentation was determined by measuring interferon-gamma (IFN-gamma) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium-hypersensitive subjects. Beryllium 152-161 interferon gamma Homo sapiens 110-126 19191908-5 2009 The effect of these CLIP-derived high-affinity peptides on beryllium presentation was determined by measuring interferon-gamma (IFN-gamma) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium-hypersensitive subjects. Beryllium 152-161 interferon gamma Homo sapiens 128-137 19191908-5 2009 The effect of these CLIP-derived high-affinity peptides on beryllium presentation was determined by measuring interferon-gamma (IFN-gamma) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium-hypersensitive subjects. Beryllium 152-161 interferon gamma Homo sapiens 110-126 19191908-5 2009 The effect of these CLIP-derived high-affinity peptides on beryllium presentation was determined by measuring interferon-gamma (IFN-gamma) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium-hypersensitive subjects. Beryllium 152-161 interferon gamma Homo sapiens 128-137 19191908-6 2009 CLIP-YY did inhibit beryllium presentation and T-cell activation, while CLIP-QY and CLIP-RF markedly enhanced the IFN-gamma response to beryllium. Beryllium 136-145 interferon gamma Homo sapiens 114-123 19191908-7 2009 Anti-HLA-DP monoclonal antibody blocked the beryllium-induced IFN-gamma release in the presence of CLIP-QY (88%) and CLIP-RF (76%). Beryllium 44-53 interferon gamma Homo sapiens 62-71 19191908-8 2009 A similar effect was observed for CLIP-YY capability to block IFN-gamma release by beryllium stimulation in the presence of CLIP-QY (79%) and CLIP-RF (76%). Beryllium 83-92 interferon gamma Homo sapiens 62-71 19499314-7 2009 In in vitro assays, we found DXM-inhibited BAFF, IFN-gamma expression, and the proliferation of lymphocytes in a dose-dependent manner. Dexamethasone 29-32 interferon gamma Homo sapiens 49-58 19740320-4 2009 In vitro culturing of muscle cells with the proinflammatory cytokines interferon-gamma, tumour necrosis factor-alpha, and interleukin (IL)-1beta synergistically increased Fas expression, susceptibility to Fas-mediated apoptosis, and the expression of cytoplasmic caspases 8 and 3. ammonium ferrous sulfate 171-174 interferon gamma Homo sapiens 70-116 19648266-8 2009 A concentration-dependent reduction in T-bet expression and production of IFN-gamma, IL-2, IL-17, but not IL-8, was observed in IBD LPMC and biopsy specimens treated with the CRAC inhibitor. lpmc 132-136 interferon gamma Homo sapiens 74-83 19542049-5 2009 Furthermore, production of IL-23 in CBDC costimulated with LPS and IL-12 caused CD4(+)CD45RO(+) memory cells to increase IFN-gamma production. cbdc 36-40 interferon gamma Homo sapiens 121-130 19542049-6 2009 Taken together, CBDCs, costimulated with LPS and IL-12, show a synergistic increase in IL-23 production via enhanced phosphorylation of ERK1/2 and p38 MAPK and consequently, an induction of IFN-gamma production in the memory cells. cbdcs 16-21 interferon gamma Homo sapiens 190-199 19615399-6 2009 RESULTS: ROS production in human neutrophil was activated by IFN-gamma in all the groups studied. ros 9-12 interferon gamma Homo sapiens 61-70 19723881-5 2009 Despite its proapoptotic effects, curcumin pretreatment of human melanoma cell lines inhibited the phosphorylation of STAT1 protein and downstream gene transcription following IFN-alpha and IFN-gamma as determined by immunoblot analysis and real time PCR, respectively. Curcumin 34-42 interferon gamma Homo sapiens 190-199 19723881-6 2009 Pretreatment of peripheral blood mononuclear cells from healthy donors with curcumin also inhibited the ability of IFN-alpha, IFN-gamma, and interleukin-2 to phosphorylate STAT proteins critical for their antitumor activity (STAT1 and STAT5, respectively) and their respective downstream gene expression as measured by real time PCR. Curcumin 76-84 interferon gamma Homo sapiens 126-135 19723881-7 2009 Finally, stimulation of natural killer (NK) cells with curcumin reduced the level of interleukin-12-induced IFN-gamma secretion, and production of granzyme b or IFN-gamma upon coculture with A375 melanoma cells or NK-sensitive K562 cells as targets. Curcumin 55-63 interferon gamma Homo sapiens 108-117 19723881-7 2009 Finally, stimulation of natural killer (NK) cells with curcumin reduced the level of interleukin-12-induced IFN-gamma secretion, and production of granzyme b or IFN-gamma upon coculture with A375 melanoma cells or NK-sensitive K562 cells as targets. Curcumin 55-63 interferon gamma Homo sapiens 161-170 19765439-3 2009 RESULTS: Patients with acute rejection episodes (ARE)-3/20 DBMI and 6/20 controls-showed increased sCD30 and IFN-gamma as well as decreased IL-10 posttransplantation compared with nonrejectors. dbmi 59-63 interferon gamma Homo sapiens 109-118 19751563-0 2009 [The role of interferon-gamma in prevention of hydrogen peroxide-induced oxidative injury to vascular endothelium]. Hydrogen Peroxide 47-64 interferon gamma Homo sapiens 13-29 19751563-1 2009 OBJECTIVE: To observe the protective effects of interferon-gamma (IFN-gamma) on hydrogen peroxide (H(2)O(2))-induced oxidative injury to vascular endothelial cell (VEC), and to explore the role of 26S proteasome protection against IFN-gamma-induced endothelial oxidative injury. Hydrogen Peroxide 80-97 interferon gamma Homo sapiens 48-64 19751563-1 2009 OBJECTIVE: To observe the protective effects of interferon-gamma (IFN-gamma) on hydrogen peroxide (H(2)O(2))-induced oxidative injury to vascular endothelial cell (VEC), and to explore the role of 26S proteasome protection against IFN-gamma-induced endothelial oxidative injury. Hydrogen Peroxide 80-97 interferon gamma Homo sapiens 66-75 19751563-1 2009 OBJECTIVE: To observe the protective effects of interferon-gamma (IFN-gamma) on hydrogen peroxide (H(2)O(2))-induced oxidative injury to vascular endothelial cell (VEC), and to explore the role of 26S proteasome protection against IFN-gamma-induced endothelial oxidative injury. Hydrogen Peroxide 80-97 interferon gamma Homo sapiens 231-240 19751563-6 2009 The damage to VEC induced by H(2)O(2) was diminished significantly after incubation with IFN-gamma (20 microg/L) for 48 hours, characterized by a decreased production of LDH and MDA (both P<0.05) and restoration of endothelium- dependent vasodilation, and Ach-induced maximum reaction of vascular relaxation was increased to (72.68+/-18.82)% (P<0.01). Hydrogen Peroxide 29-37 interferon gamma Homo sapiens 89-98 19751563-6 2009 The damage to VEC induced by H(2)O(2) was diminished significantly after incubation with IFN-gamma (20 microg/L) for 48 hours, characterized by a decreased production of LDH and MDA (both P<0.05) and restoration of endothelium- dependent vasodilation, and Ach-induced maximum reaction of vascular relaxation was increased to (72.68+/-18.82)% (P<0.01). Acetylcholine 259-262 interferon gamma Homo sapiens 89-98 19751563-7 2009 26S proteasome inhibitor lactacystin could partly antagonize the protective effects of IFN-gamma on H(2)O(2)-induced oxidative injury. lactacystin 25-36 interferon gamma Homo sapiens 87-96 19751563-7 2009 26S proteasome inhibitor lactacystin could partly antagonize the protective effects of IFN-gamma on H(2)O(2)-induced oxidative injury. Hydrogen Peroxide 100-108 interferon gamma Homo sapiens 87-96 19751563-8 2009 CONCLUSION: IFN-gamma possesses protective effects on H(2)O(2)-induced oxidative injury to vascular endothelium, and its mechanism is at least partly related with 26S proteasome. Hydrogen Peroxide 54-62 interferon gamma Homo sapiens 12-21 19635904-7 2009 Presence of IPS-1 and TRIF in dendritic cells (DCs), but not NK cells, was required for production of IFN-gamma to poly I:C in NK cells in vitro. Poly I-C 115-123 interferon gamma Homo sapiens 102-111 19635904-8 2009 Moreover CD8alpha(+) conventional dendritic cells (cDCs), but not CD8alpha(-) cDCs, expressed genes for type I IFNs, IL-6, and IL-12p40 in response to poly I:C stimulation, and were also responsible for inducing IFN-gamma production in NK cells. Poly I-C 151-159 interferon gamma Homo sapiens 212-221 19645607-8 2009 IFN-gamma release was diminished in the pyridostigmine group (p = 0.016) and expression of IL-4 (p = 0.010) and IL-10 (p = 0.015) increased. Pyridostigmine Bromide 40-54 interferon gamma Homo sapiens 0-9 19360901-5 2009 Soluble CD14 inhibited lipopolysaccharide (LPS)- or LPS/interferon-gamma-induced nitric oxide production and cell death of microglia and astrocytes. Nitric Oxide 81-93 interferon gamma Homo sapiens 56-72 19443843-3 2009 METHODS AND RESULTS: Cells from the fibrous cap of human atherosclerotic lesions were sensitized by interferon-gamma (IFNgamma) to Fas-induced apoptosis, in a Bcl-X(L) reversible manner. ammonium ferrous sulfate 131-134 interferon gamma Homo sapiens 100-116 19443843-3 2009 METHODS AND RESULTS: Cells from the fibrous cap of human atherosclerotic lesions were sensitized by interferon-gamma (IFNgamma) to Fas-induced apoptosis, in a Bcl-X(L) reversible manner. ammonium ferrous sulfate 131-134 interferon gamma Homo sapiens 118-126 19645607-10 2009 Pyridostigmine led to an increase in the antiinflammatory cytokine IL-10 and a decrease in T cell proliferation and production of the proinflammatory cytokine IFN-gamma. Pyridostigmine Bromide 0-14 interferon gamma Homo sapiens 159-168 19886038-0 2009 Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells. Simvastatin 0-11 interferon gamma Homo sapiens 36-52 19886038-4 2009 Based on the above description, we compared the effect of simvastatin on IFNgamma-induced COX-2 expression in human monocytes versus murine macrophages. Simvastatin 58-69 interferon gamma Homo sapiens 73-81 19886038-5 2009 In a result, we found that simvastatin suppresses IFNgamma-induced COX-2 expression in human THP-1 monocytes, but rather, potentiates IFNgamma-induced COX-2 expression in murine RAW264.7 macrophages. Simvastatin 27-38 interferon gamma Homo sapiens 50-58 19886038-5 2009 In a result, we found that simvastatin suppresses IFNgamma-induced COX-2 expression in human THP-1 monocytes, but rather, potentiates IFNgamma-induced COX-2 expression in murine RAW264.7 macrophages. Simvastatin 27-38 interferon gamma Homo sapiens 134-142 19886038-7 2009 Our findings showed that simvastatin is likely to suppress IFNgamma-induced COX-2 expression by inhibiting STAT1/3 activation in human THP-1 cells, but not in murine RAW264.7 cells. Simvastatin 25-36 interferon gamma Homo sapiens 59-67 19886038-8 2009 Thus, we concluded that IFNgamma-induced COX-2 expression is differently regulated by simvastatin depending on species specific mechanism. Simvastatin 86-97 interferon gamma Homo sapiens 24-32 19556308-7 2009 The production of IFN-gamma was associated with the induction of T-bet. t-bet 65-70 interferon gamma Homo sapiens 18-27 19594754-0 2009 Fluvastatin inhibits expression of the chemokine MDC/CCL22 induced by interferon-gamma in HaCaT cells, a human keratinocyte cell line. Fluvastatin 0-11 interferon gamma Homo sapiens 70-86 19594754-6 2009 KEY RESULTS: Fluvastatin, but not atorvastatin or simvastatin, inhibited MDC expression induced by interferon (IFN)-gamma and NF-kappaB activation. Fluvastatin 13-24 interferon gamma Homo sapiens 99-121 19594754-9 2009 Interestingly, fluvastatin suppressed IFN-gamma-induced NF-kappaB activation in parallel with p38 MAPK phosphorylation. Fluvastatin 15-26 interferon gamma Homo sapiens 38-47 19594754-10 2009 CONCLUSIONS AND IMPLICATIONS: These results indicate that fluvastatin inhibited expression of the CC chemokine MDC induced by IFN-gamma in HaCaT cells, by inhibiting NF-kappaB activation via the p38 MAPK pathway. Fluvastatin 58-69 interferon gamma Homo sapiens 126-135 19242516-0 2009 Poly(I:C)-Treated human langerhans cells promote the differentiation of CD4+ T cells producing IFN-gamma and IL-10. Poly I-C 0-9 interferon gamma Homo sapiens 95-104 19646207-8 2009 Lastly, percentages of IFN-gamma(+) and IL-10(+) cells were higher in L-CL as compared to E-CL, with CD4(+) T-cells and CD68(+) monocytes as the main sources of these cytokines, respectively. l-cl 70-74 interferon gamma Homo sapiens 23-32 19514839-0 2009 Interferon-gamma is induced in human peripheral blood immune cells in vitro by sodium stibogluconate/interleukin-2 and mediates its antitumor activity in vivo. Antimony Sodium Gluconate 79-100 interferon gamma Homo sapiens 0-16 19199463-6 2009 RESULTS: Upon interferon-gamma (IFN-gamma) stimulation, the glioma cells greatly increased their IDO mRNA expression concomitant with depletion of Trp. Tryptophan 147-150 interferon gamma Homo sapiens 14-30 19199463-6 2009 RESULTS: Upon interferon-gamma (IFN-gamma) stimulation, the glioma cells greatly increased their IDO mRNA expression concomitant with depletion of Trp. Tryptophan 147-150 interferon gamma Homo sapiens 32-41 19199463-9 2009 CONCLUSIONS: These findings suggest that the robust IDO expression with rapid consumption of Trp in human glioma cells induced by IFN-gamma could lead to immune resistance in glioma cells. Tryptophan 93-96 interferon gamma Homo sapiens 130-139 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Tamoxifen 179-188 interferon gamma Homo sapiens 250-258 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Colforsin 190-199 interferon gamma Homo sapiens 250-258 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Phenylephrine 201-214 interferon gamma Homo sapiens 250-258 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Fluorouracil 295-309 interferon gamma Homo sapiens 250-258 19473985-1 2009 Recent studies have demonstrated that kynurenic acid (KYNA), a compound produced endogenously by the interferon-gamma-induced degradation of tryptophan by indoleamine 2,3-dioxygenase, activates the previously orphaned G protein-coupled receptor, GPR35. Kynurenic Acid 38-52 interferon gamma Homo sapiens 101-117 19647514-3 2009 IFN-gamma induces sequential phosphorylation of Ser(886) and Ser(999) in the noncatalytic linker connecting the synthetase cores. Serine 48-51 interferon gamma Homo sapiens 0-9 19647514-3 2009 IFN-gamma induces sequential phosphorylation of Ser(886) and Ser(999) in the noncatalytic linker connecting the synthetase cores. Serine 61-64 interferon gamma Homo sapiens 0-9 19473985-1 2009 Recent studies have demonstrated that kynurenic acid (KYNA), a compound produced endogenously by the interferon-gamma-induced degradation of tryptophan by indoleamine 2,3-dioxygenase, activates the previously orphaned G protein-coupled receptor, GPR35. Kynurenic Acid 54-58 interferon gamma Homo sapiens 101-117 19473985-1 2009 Recent studies have demonstrated that kynurenic acid (KYNA), a compound produced endogenously by the interferon-gamma-induced degradation of tryptophan by indoleamine 2,3-dioxygenase, activates the previously orphaned G protein-coupled receptor, GPR35. Tryptophan 141-151 interferon gamma Homo sapiens 101-117 19542364-3 2009 IFN-gamma treatment rapidly activated GSK-3beta via neutral sphingomyelinase- and okadaic acid-sensitive phosphatase-regulated dephosphorylation at Ser(9), and proline-rich tyrosine kinase 2 (Pyk2)-regulated phosphorylation at Tyr(216). Serine 148-151 interferon gamma Homo sapiens 0-9 19378341-5 2009 Upon IFNgamma exposure, TAM purified from ovarian cancer ascites recover a M1 phenotype (IL-10(low), IL-12(high)), express high levels of CD86 and low levels of ILT3, enhance the proliferation of CD4(+) T lymphocytes and potentiate the cytotoxic properties of a MelanA-specific CD8(+) T cell clone. tam 24-27 interferon gamma Homo sapiens 5-13 19378341-9 2009 Together, these data show that IFNgamma overcomes TAM-induced immunosuppression by preventing TAM generation and functions. tam 50-53 interferon gamma Homo sapiens 31-39 19378341-9 2009 Together, these data show that IFNgamma overcomes TAM-induced immunosuppression by preventing TAM generation and functions. tam 94-97 interferon gamma Homo sapiens 31-39 19542364-3 2009 IFN-gamma treatment rapidly activated GSK-3beta via neutral sphingomyelinase- and okadaic acid-sensitive phosphatase-regulated dephosphorylation at Ser(9), and proline-rich tyrosine kinase 2 (Pyk2)-regulated phosphorylation at Tyr(216). Tyrosine 227-230 interferon gamma Homo sapiens 0-9 19902100-3 2009 The induction of dendritic cell differentiation after treatment with dehydroepiandrosterone sulfate was accompanied by an increase in the production of interferon-gamma. Dehydroepiandrosterone Sulfate 69-99 interferon gamma Homo sapiens 152-168 19597544-3 2009 The high arginase activity causes local depletion of L-arginine, which impairs the capacity of T cells in the lesion to proliferate and to produce interferon-gamma, while T cells in the local draining lymph nodes respond normally. Arginine 53-63 interferon gamma Homo sapiens 147-163 19633608-0 2009 A new synthetic compound, 2-OH, enhances interleukin-2 and interferon-gamma gene expression in human peripheral blood mononuclear cells. 6-hydroxy-2-tosylisoquinolin-1(2H)-one 26-30 interferon gamma Homo sapiens 59-75 19633608-6 2009 Results demonstrated that 2-OH stimulated IL-2 and IFN-gamma production in PBMC. 6-hydroxy-2-tosylisoquinolin-1(2H)-one 26-30 interferon gamma Homo sapiens 51-60 19633608-7 2009 Data from reverse transcription-polymerase chain reaction (RT-PCR) and real-time PCR indicated that IL-2 and IFN-gamma mRNA expression in PBMC could be induced by 2-OH. 6-hydroxy-2-tosylisoquinolin-1(2H)-one 163-167 interferon gamma Homo sapiens 109-118 19633608-8 2009 Therefore, 2-OH enhanced IL-2 and IFN-gamma production in PBMC by modulation their gene expression. 6-hydroxy-2-tosylisoquinolin-1(2H)-one 11-15 interferon gamma Homo sapiens 34-43 19342094-5 2009 To investigate the effectiveness of micelle-incorporated SP600125 in preventing the islet cell death, we challenged the islets with TNF-alpha, IL-1, and IFN gamma. pyrazolanthrone 57-65 interferon gamma Homo sapiens 153-162 19416233-5 2009 We investigated whether HF production of these AMPs was induced by prototypic microbial products and proinflammatory cytokines, i.e. interferon (IFN)-gamma. Adenylyl sulfate 47-51 interferon gamma Homo sapiens 133-155 19902100-6 2009 Dehydroepiandrosterone sulfate increased the ability of dendritic cells to stimulate Th1 cytokine production by T cells (interferon-gamma). Dehydroepiandrosterone Sulfate 0-30 interferon gamma Homo sapiens 121-137 19332094-5 2009 Thirty days after RFTA, a significant reduction in CD25+Foxp3+ counts with an increase in CD4+ T-cell proliferation and number of interferon-gamma-secreting cells was observed. rfta 18-22 interferon gamma Homo sapiens 130-146 19549798-7 2009 A combination of cytokines (tumor necrosis factor-alpha, IFN-gamma, and bacterial endotoxin lipopolysaccharide) induced inflammation-related genes such as inducible nitric oxide synthase and cyclooxygenase-2, which was significantly suppressed by treatment with pterostilbene. pterostilbene 262-275 interferon gamma Homo sapiens 57-66 19508976-10 2009 Furthermore, we found that long-term culture of CD4(+) T cells in the presence of bortezomib promotes the emergence of a regulatory T-cell population that significantly inhibits proliferation, IFN-gamma production and CD40L expression among stimulated effector T cells. Bortezomib 82-92 interferon gamma Homo sapiens 193-202 19336263-11 2009 Sinomenine was also found to elicit a decrease in the serum levels of IFN-gamma. sinomenine 0-10 interferon gamma Homo sapiens 70-79 19523671-4 2009 RESULTS: Primary human sinus epithelial cells isolated from patients with CRS were at an activated state with upregulated expression of HLA-DR, IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and TNF-related apoptosis-inducing ligand (TRAIL) compared with healthy individuals. 3-cresol 74-77 interferon gamma Homo sapiens 144-153 19822077-7 2009 The induction of IFN-gamma production by Pd was assessed in PBMC by the ELISpot assay. Palladium 41-43 interferon gamma Homo sapiens 17-26 19822077-14 2009 Oral clinical symptoms in patients with Pd dental prostheses were associated with measurable levels of Pd in the biological fluids, the induction of Pd-specific IFN-gamma responses in PBMC and the clinical evidence of skin sensitization to Pd. Palladium 40-42 interferon gamma Homo sapiens 161-170 19523671-4 2009 RESULTS: Primary human sinus epithelial cells isolated from patients with CRS were at an activated state with upregulated expression of HLA-DR, IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and TNF-related apoptosis-inducing ligand (TRAIL) compared with healthy individuals. 3-cresol 74-77 interferon gamma Homo sapiens 196-205 19401383-7 2009 Moreover, membrane NadA effects, unlike NadA(Delta351-405) ones, were much less IFN-gamma-sensitive. arachidonyl dopamine 19-23 interferon gamma Homo sapiens 80-89 19493573-3 2009 We show here that pre-treatment of trophoblast cells and certain cancer cells with agents that activate stress pathways (Ras oncogene, PMA or H2O2) and induce senescence can substantially enhance the induction of immune response genes (MHC class II, CD40, MICA, MICB) by HDACi and restore a vigorous IFN-gamma response in trophoblast cells and tumor cells. Hydrogen Peroxide 142-146 interferon gamma Homo sapiens 300-309 19635391-4 2009 Exposure of BE(2)-C cells to the heavy metals CdCl(2) and HgCl(2) and to the mitochondrial complex I inhibitor rotenone inhibited interleukin-6, interferon-gamma and ciliary neurotrophic factor-mediated Jak/STAT signaling, reduced Jak1 and Jak2 auto-phosphorylation and induced Jak tyrosine nitration. Rotenone 111-119 interferon gamma Homo sapiens 145-193 19221048-8 2009 In humans, IFN-gamma / IL-4 was significantly higher after the omega-3 versus the omega-6 enhanced diet. omega-6 82-89 interferon gamma Homo sapiens 11-20 19635391-4 2009 Exposure of BE(2)-C cells to the heavy metals CdCl(2) and HgCl(2) and to the mitochondrial complex I inhibitor rotenone inhibited interleukin-6, interferon-gamma and ciliary neurotrophic factor-mediated Jak/STAT signaling, reduced Jak1 and Jak2 auto-phosphorylation and induced Jak tyrosine nitration. Tyrosine 282-290 interferon gamma Homo sapiens 145-193 19960790-2 2009 Treatment with interferon-gamma (IFN-gamma) 1beta has been reported to significantly improve lung function and arterial oxygen saturation in a first randomized controlled trial; unexpectedly, these findings have not been confirmed in a subsequent large placebo-controlled randomized study. Oxygen 120-126 interferon gamma Homo sapiens 15-31 19960790-2 2009 Treatment with interferon-gamma (IFN-gamma) 1beta has been reported to significantly improve lung function and arterial oxygen saturation in a first randomized controlled trial; unexpectedly, these findings have not been confirmed in a subsequent large placebo-controlled randomized study. Oxygen 120-126 interferon gamma Homo sapiens 33-49 19584951-8 2009 Prednisone and azathioprine treatment decreased total serum IgG, IgE, IFN-gamma and IL-4 levels, and blood CD19+ and CD23+ cells; however serum IL-12, TNFalpha and blood CD4+ T cells increased with treatment. Prednisone 0-10 interferon gamma Homo sapiens 70-79 19584951-8 2009 Prednisone and azathioprine treatment decreased total serum IgG, IgE, IFN-gamma and IL-4 levels, and blood CD19+ and CD23+ cells; however serum IL-12, TNFalpha and blood CD4+ T cells increased with treatment. Azathioprine 15-27 interferon gamma Homo sapiens 70-79 19386602-10 2009 An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed the IL-1beta-, IFN-gamma- and TNF-alpha-induced IL-32 mRNA expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 47-55 interferon gamma Homo sapiens 97-106 19494326-3 2009 We provide evidence that metformin attenuates the induction of EAE by restricting the infiltration of mononuclear cells into the CNS, down-regulating the expression of proinflammatory cytokines (IFN-gamma, TNF-alpha, IL-6, IL-17, and inducible NO synthase (iNOS)), cell adhesion molecules, matrix metalloproteinase 9, and chemokine (RANTES). Metformin 25-34 interferon gamma Homo sapiens 195-204 19433108-11 2009 The increased levels of IL-13 in the sensitive individuals to mite antigen (rDER P I) and IFN-gamma in NiSO4 sensitized individuals confirm the role of the type TH2 response in the atopies and TH1 type in DCA. nickel sulfate 103-108 interferon gamma Homo sapiens 90-99 19635059-0 2009 Synthesis and immunomodulation of human lymphocyte proliferation and cytokine (interferon-gamma) production of four novel malonitrilamides. malonitrilamides 122-138 interferon gamma Homo sapiens 79-95 18762254-8 2009 Simultaneous exposure to TNF-alpha- and IFN-gamma-induced significant changes in barrier function and paracellular permeability in the cocultures of HBEC/Wi-38 but not in the 16HBE14o-/Wi-38. 16hbe14o 175-183 interferon gamma Homo sapiens 40-49 19298850-6 2009 Anastrozole induced the increased levels of proinflammatory cytokines, IFN-gamma, IL-12, and the decreased levels of IL-4, IL-10 secretion. Anastrozole 0-11 interferon gamma Homo sapiens 71-80 19602041-1 2009 The interferon (IFN)-gamma-inducible tryptophan degrading enzyme indoleamine 2,3-dioxygenase (IDO) has not only been recognized as a potent antimicrobial effector molecule for the last 25 years but was recently found also to have potent immunoregulatory properties. Tryptophan 37-47 interferon gamma Homo sapiens 4-26 19450450-4 2009 We found that cultured h-IPE cells significantly inhibited T cell proliferation and the IFN-gamma production by the target T cells from both the allogeneic and autogeneic peripheral blood mononuclear cells (PBMCs). h-ipe 23-28 interferon gamma Homo sapiens 88-97 19019091-0 2009 Differential effects of tumour necrosis factor-alpha and interleukin-12 on isopentenyl pyrophosphate-stimulated interferon-gamma production by cord blood Vgamma9 T cells. isopentenyl pyrophosphate 75-100 interferon gamma Homo sapiens 112-128 19543499-7 2009 The IFN-gamma/IL-5 ratio of the CD3+ and CD4+ cells were increased significantly after 8 weeks and maintained until 1 yr of RIT, while there were no changes in the control group. Ritonavir 124-127 interferon gamma Homo sapiens 4-13 19450160-10 2009 Analysis of patients who developed PAF after 1 day post-CABG revealed a higher level of IL-10 and IFN-gamma at 24 h post-CABG compared with patients without PAF. Platelet Activating Factor 35-38 interferon gamma Homo sapiens 98-107 19274709-12 2009 EWSs lack IFNgamma-inducible HLA class II, due to lack of functional CIITA. ewss 0-4 interferon gamma Homo sapiens 10-18 19691530-7 2009 Treatment of cultured SC with interferon-gamma (IFN-gamma) or dexamethasone (DM) followed by the addition of man/BSA-FITC and analysis by flow cytometry shows down- or upregulation, respectively, of man/BSA-FITC uptake. Fluorescein-5-isothiocyanate 207-211 interferon gamma Homo sapiens 30-46 19691530-7 2009 Treatment of cultured SC with interferon-gamma (IFN-gamma) or dexamethasone (DM) followed by the addition of man/BSA-FITC and analysis by flow cytometry shows down- or upregulation, respectively, of man/BSA-FITC uptake. Fluorescein-5-isothiocyanate 207-211 interferon gamma Homo sapiens 48-57 19493208-6 2009 Notably, SAAG-4 reduced host CD4 T cell expression of the signature Th1 cytokine IFN-gamma while simultaneously increasing expression of IL-4. saag-4 9-15 interferon gamma Homo sapiens 81-90 19634684-2 2009 The preparation and application of the research couple IFN-gamma and TNF-alpha to the polystyrene cell culture plate were performed using the Photo-immobilization method, with different doses (20 ng/well and 200 ng/well) and synthesized optical active material. Polystyrenes 86-97 interferon gamma Homo sapiens 55-64 19371952-4 2009 Both forskolin (a direct activator of adenylyl cyclase) and dibutyryl-cAMP (DBcAMP, a permeable analog of cAMP) suppressed production of TARC and MDC in parallel with the activation of NF-kappaB in IFN-gamma and TNF-alpha-stimulated HaCaT cells. Colforsin 5-14 interferon gamma Homo sapiens 198-207 19371952-4 2009 Both forskolin (a direct activator of adenylyl cyclase) and dibutyryl-cAMP (DBcAMP, a permeable analog of cAMP) suppressed production of TARC and MDC in parallel with the activation of NF-kappaB in IFN-gamma and TNF-alpha-stimulated HaCaT cells. Bucladesine 76-82 interferon gamma Homo sapiens 198-207 19371952-8 2009 Of note, the IFN-gamma plus TNF-alpha-stimulated activation of p38 MAPK was suppressed following incubation with forskolin or DBcAMP alone. Colforsin 113-122 interferon gamma Homo sapiens 13-22 19371952-8 2009 Of note, the IFN-gamma plus TNF-alpha-stimulated activation of p38 MAPK was suppressed following incubation with forskolin or DBcAMP alone. Bucladesine 126-132 interferon gamma Homo sapiens 13-22 19345424-5 2009 To simulate inflammatory conditions, we activated THBMEC with the inflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma), which up-regulated chemokine and adhesion molecule expression in THBMEC without affecting the distribution of immunoreactivity for tight junction-associated proteins. thbmec 50-56 interferon gamma Homo sapiens 133-160 19345424-5 2009 To simulate inflammatory conditions, we activated THBMEC with the inflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma), which up-regulated chemokine and adhesion molecule expression in THBMEC without affecting the distribution of immunoreactivity for tight junction-associated proteins. thbmec 228-234 interferon gamma Homo sapiens 133-160 19424019-8 2009 In conclusion, lymphopenia-induced IL-7 production after induction with ATG and sirolimus might lead to emergence of IFN-gamma-secreting CD8+ T-cells responsible for acute rejection after immunosuppression withdrawal. Sirolimus 80-89 interferon gamma Homo sapiens 117-126 19144412-11 2009 The BALF IL-4:IFN-gamma ratio significantly decreased over time in the IN RIT group (mean+/-SEM, D1 2.4+/-0.2, M6 1.0+/-0.2). Ritonavir 74-77 interferon gamma Homo sapiens 14-23 19306841-6 2009 Stimulation of HeLa cells with IFNgamma upregulates expression of P2X(7) mRNA and full-length protein, modifies ATP-dependent calcium fluxes, and renders the cells sensitive to ATP-induced apoptosis, which can be blocked by a P2X(7) antagonist. Adenosine Triphosphate 112-115 interferon gamma Homo sapiens 31-39 19306841-6 2009 Stimulation of HeLa cells with IFNgamma upregulates expression of P2X(7) mRNA and full-length protein, modifies ATP-dependent calcium fluxes, and renders the cells sensitive to ATP-induced apoptosis, which can be blocked by a P2X(7) antagonist. Calcium 126-133 interferon gamma Homo sapiens 31-39 19306841-6 2009 Stimulation of HeLa cells with IFNgamma upregulates expression of P2X(7) mRNA and full-length protein, modifies ATP-dependent calcium fluxes, and renders the cells sensitive to ATP-induced apoptosis, which can be blocked by a P2X(7) antagonist. Adenosine Triphosphate 177-180 interferon gamma Homo sapiens 31-39 19306841-7 2009 IFNgamma treatment also increased dramatically the sensitivity of the intestinal epithelial cell line, HCT8, to ATP-induced apoptosis. Adenosine Triphosphate 112-115 interferon gamma Homo sapiens 0-8 19507259-0 2009 Enhanced IFNgamma production in adenosine-treated CHO cells: a mechanistic study. Adenosine 32-41 interferon gamma Homo sapiens 9-17 19507259-0 2009 Enhanced IFNgamma production in adenosine-treated CHO cells: a mechanistic study. cho 50-53 interferon gamma Homo sapiens 9-17 19507259-4 2009 Chinese hamster ovary (CHO) cells expressing human interferon-gamma (IFNgamma) were treated with 1 mM adenosine on Day 2 of culture. Adenosine 102-111 interferon gamma Homo sapiens 51-67 19507259-4 2009 Chinese hamster ovary (CHO) cells expressing human interferon-gamma (IFNgamma) were treated with 1 mM adenosine on Day 2 of culture. Adenosine 102-111 interferon gamma Homo sapiens 69-77 19196551-4 2009 In HIV infection, IFN-gamma production by CD3 depleted PBMC was reduced in response to poly (I:C), while response to IL-12 was intact in HCV and HIV infections. poly 87-91 interferon gamma Homo sapiens 18-27 19174326-3 2009 CD3(+)CD4(+) IFN-gamma-producing (Th1) cells reactive to commensal bacteria were demonstrated at frequencies ranging from 0.05 to 2.28% in LPMC. lpmc 139-143 interferon gamma Homo sapiens 13-22 19200788-7 2009 In vitro experiments showed that CsA and dexamethasone could decrease the frequencies of Th1 and Th17 cells and inhibit IL-17 and IFN-gamma production. Cyclosporine 33-36 interferon gamma Homo sapiens 130-139 19200788-7 2009 In vitro experiments showed that CsA and dexamethasone could decrease the frequencies of Th1 and Th17 cells and inhibit IL-17 and IFN-gamma production. Dexamethasone 41-54 interferon gamma Homo sapiens 130-139 19479009-5 2009 Effects have been reported after 4 weeks of exposure to TCE at doses as low as 0.1 mg/kg/day in drinking water and have included increased antinuclear antibodies and interferon-gamma (IFN-gamma) and decreased secretion of interleukin-4 (IL-4), consistent with an inflammatory response. Trichloroethylene 56-59 interferon gamma Homo sapiens 166-182 18182335-6 2009 During the course of the acute disease, a sharp increase in interferon gamma levels was detected in serum and in the supernatant of both unstimulated and phytoemagglutinin/lipopolysaccharide-stimulated peripheral blood mononuclear cells. phytoemagglutinin 154-171 interferon gamma Homo sapiens 60-76 19479009-5 2009 Effects have been reported after 4 weeks of exposure to TCE at doses as low as 0.1 mg/kg/day in drinking water and have included increased antinuclear antibodies and interferon-gamma (IFN-gamma) and decreased secretion of interleukin-4 (IL-4), consistent with an inflammatory response. Trichloroethylene 56-59 interferon gamma Homo sapiens 184-193 19479009-8 2009 Two studies in humans reported an increase in IL-2 or IFN-gamma and a decrease in IL-4 in relation to occupational or environmental TCE exposure. Trichloroethylene 132-135 interferon gamma Homo sapiens 54-63 19384872-0 2009 Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells. Dinoprostone 0-16 interferon gamma Homo sapiens 69-78 19384872-4 2009 TCR triggering in the presence of PGE2 increased IL-17 and reduced IFN-gamma production by freshly isolated memory T cells or T-cell clones. Dinoprostone 34-38 interferon gamma Homo sapiens 67-76 19589242-3 2009 Simvastatin induced down-regulation of OX40 and OX40L mRNA and protein in a concentration-dependent manner, and antagonized the interferon-gamma-induced increase in OX40 and OX40L mRNA and protein levels. Simvastatin 0-11 interferon gamma Homo sapiens 128-144 19476491-0 2009 Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide--interference with interferon-gamma-STAT1-mediated killing. Oligodeoxyribonucleotides 126-146 interferon gamma Homo sapiens 166-182 19476491-11 2009 Thus, although it can inhibit STAT3, the hairpin STAT3 oligodeoxynucleotide appears also to inhibit STAT1-mediated interferon-gamma cell killing, highlighting the need to optimize STAT3-targeting oligodeoxynucleotides. Oligodeoxyribonucleotides 55-75 interferon gamma Homo sapiens 115-131 18562404-3 2009 In this study, we examined kynurenine pathway activity by measuring tryptophan breakdown, a number of pathway metabolites and interferon gamma (IFN-gamma), which is the preferential activator of the first-step enzyme, indoleamine dioxygenase (IDO), in the plasma of patients with major psychotic disorder. Kynurenine 27-37 interferon gamma Homo sapiens 126-153 19276231-8 2009 Treating all cell types with the PPARgamma agonist, rosiglitazone, or pioglitazone, the IFNgamma plus TNFalpha-induced CXCL9 and CXCL11 release was dose dependently (0.1-20 microm) suppressed. Rosiglitazone 52-65 interferon gamma Homo sapiens 88-96 19276231-8 2009 Treating all cell types with the PPARgamma agonist, rosiglitazone, or pioglitazone, the IFNgamma plus TNFalpha-induced CXCL9 and CXCL11 release was dose dependently (0.1-20 microm) suppressed. Pioglitazone 70-82 interferon gamma Homo sapiens 88-96 19439213-3 2009 In this study, we investigated the regulation of antioxidant enzyme systems in microglial cells by interferon-gamma (IFN-gamma) and found that pretreatment with IFN-gamma for 20 h protected microglial cells from the toxicity of various reactive species such as hydrogen peroxide (H(2)O(2)), superoxide anion, 4-hydroxy-2(E)-nonenal, and peroxynitrite. Hydrogen Peroxide 261-278 interferon gamma Homo sapiens 161-170 19351841-0 2009 Natural killer cell IFN-gamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients. Imatinib Mesylate 69-86 interferon gamma Homo sapiens 20-29 19439213-3 2009 In this study, we investigated the regulation of antioxidant enzyme systems in microglial cells by interferon-gamma (IFN-gamma) and found that pretreatment with IFN-gamma for 20 h protected microglial cells from the toxicity of various reactive species such as hydrogen peroxide (H(2)O(2)), superoxide anion, 4-hydroxy-2(E)-nonenal, and peroxynitrite. Hydrogen Peroxide 280-288 interferon gamma Homo sapiens 161-170 19439213-3 2009 In this study, we investigated the regulation of antioxidant enzyme systems in microglial cells by interferon-gamma (IFN-gamma) and found that pretreatment with IFN-gamma for 20 h protected microglial cells from the toxicity of various reactive species such as hydrogen peroxide (H(2)O(2)), superoxide anion, 4-hydroxy-2(E)-nonenal, and peroxynitrite. Superoxides 291-307 interferon gamma Homo sapiens 161-170 19439213-3 2009 In this study, we investigated the regulation of antioxidant enzyme systems in microglial cells by interferon-gamma (IFN-gamma) and found that pretreatment with IFN-gamma for 20 h protected microglial cells from the toxicity of various reactive species such as hydrogen peroxide (H(2)O(2)), superoxide anion, 4-hydroxy-2(E)-nonenal, and peroxynitrite. 4-hydroxy-2(e)-nonenal 309-331 interferon gamma Homo sapiens 161-170 19439213-3 2009 In this study, we investigated the regulation of antioxidant enzyme systems in microglial cells by interferon-gamma (IFN-gamma) and found that pretreatment with IFN-gamma for 20 h protected microglial cells from the toxicity of various reactive species such as hydrogen peroxide (H(2)O(2)), superoxide anion, 4-hydroxy-2(E)-nonenal, and peroxynitrite. Peroxynitrous Acid 337-350 interferon gamma Homo sapiens 161-170 19439213-4 2009 The cytoprotective effect of IFN-gamma pretreatment was abolished by the protein synthesis inhibitor cycloheximide. Cycloheximide 101-114 interferon gamma Homo sapiens 29-38 19439213-8 2009 Transfection with siRNA of Mn-SOD abolished both up-regulation of Mn-SOD expression and protection from H(2)O(2) toxicity by IFN-gamma pretreatment. Hydrogen Peroxide 104-112 interferon gamma Homo sapiens 125-134 19154548-2 2009 In this study, the frequency of circulating specific T cells was analyzed by interferon-gamma (IFN-gamma) enzyme-linked immunospot assay in 22 patients with an allergic MPE to amoxicillin (amox). Amoxicillin 176-187 interferon gamma Homo sapiens 77-93 19046800-0 2009 Nimesulide inhibits IFN-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells by COX-2 and PGE2 independent mechanisms. nimesulide 0-10 interferon gamma Homo sapiens 20-29 19046800-0 2009 Nimesulide inhibits IFN-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells by COX-2 and PGE2 independent mechanisms. Dinoprostone 121-125 interferon gamma Homo sapiens 20-29 19046800-5 2009 We demonstrated that nimesulide was able to inhibit IFN-gamma-induced PD-L1 surface expression in breast cancer cells. nimesulide 21-31 interferon gamma Homo sapiens 52-61 19154548-2 2009 In this study, the frequency of circulating specific T cells was analyzed by interferon-gamma (IFN-gamma) enzyme-linked immunospot assay in 22 patients with an allergic MPE to amoxicillin (amox). Amoxicillin 176-187 interferon gamma Homo sapiens 95-104 19154548-2 2009 In this study, the frequency of circulating specific T cells was analyzed by interferon-gamma (IFN-gamma) enzyme-linked immunospot assay in 22 patients with an allergic MPE to amoxicillin (amox). Amoxicillin 176-180 interferon gamma Homo sapiens 77-93 19154548-2 2009 In this study, the frequency of circulating specific T cells was analyzed by interferon-gamma (IFN-gamma) enzyme-linked immunospot assay in 22 patients with an allergic MPE to amoxicillin (amox). Amoxicillin 176-180 interferon gamma Homo sapiens 95-104 19154548-6 2009 Finally, analysis of drug-specific T cells in one patient allergic to ticarcillin (a penicillin antibiotic distinct from amox) revealed the presence of IFN-gamma-producing T cells reactive to ticarcillin and several other betalactam antibiotics, suggesting that the IFN-gamma ELISPOT assay is able to detect T cell cross-reactivity against chemically related drugs. Penicillins 85-95 interferon gamma Homo sapiens 152-161 19154548-6 2009 Finally, analysis of drug-specific T cells in one patient allergic to ticarcillin (a penicillin antibiotic distinct from amox) revealed the presence of IFN-gamma-producing T cells reactive to ticarcillin and several other betalactam antibiotics, suggesting that the IFN-gamma ELISPOT assay is able to detect T cell cross-reactivity against chemically related drugs. Ticarcillin 70-81 interferon gamma Homo sapiens 152-161 19154548-6 2009 Finally, analysis of drug-specific T cells in one patient allergic to ticarcillin (a penicillin antibiotic distinct from amox) revealed the presence of IFN-gamma-producing T cells reactive to ticarcillin and several other betalactam antibiotics, suggesting that the IFN-gamma ELISPOT assay is able to detect T cell cross-reactivity against chemically related drugs. Ticarcillin 70-81 interferon gamma Homo sapiens 266-275 19467635-6 2009 Naringenin also inhibited LPS/IFN-gamma-induced p38 mitogen-activated protein kinase (MAPK) phosphorylation and downstream signal transducer and activator of transcription-1 (STAT-1) in LPS/IFN-gamma stimulated primary mixed glial cells. naringenin 0-10 interferon gamma Homo sapiens 30-39 19467635-3 2009 We found that the flavanones naringenin and hesperetin and the flavanols (+)-catechin and (-)-epicatechin, but not the anthocyanidins cyanidin and pelargonidin, attenuated LPS/IFN-gamma-induced TNF-alpha production in glial cells. hesperetin 44-54 interferon gamma Homo sapiens 176-185 19467635-6 2009 Naringenin also inhibited LPS/IFN-gamma-induced p38 mitogen-activated protein kinase (MAPK) phosphorylation and downstream signal transducer and activator of transcription-1 (STAT-1) in LPS/IFN-gamma stimulated primary mixed glial cells. naringenin 0-10 interferon gamma Homo sapiens 190-199 19467635-3 2009 We found that the flavanones naringenin and hesperetin and the flavanols (+)-catechin and (-)-epicatechin, but not the anthocyanidins cyanidin and pelargonidin, attenuated LPS/IFN-gamma-induced TNF-alpha production in glial cells. flavanols 63-72 interferon gamma Homo sapiens 176-185 19467635-3 2009 We found that the flavanones naringenin and hesperetin and the flavanols (+)-catechin and (-)-epicatechin, but not the anthocyanidins cyanidin and pelargonidin, attenuated LPS/IFN-gamma-induced TNF-alpha production in glial cells. Catechin 90-105 interferon gamma Homo sapiens 176-185 19467635-4 2009 Naringenin also inhibited LPS/IFN-gamma-induced iNOS expression and nitric oxide production in glial cells, thus showing the strongest anti-inflammatory activity among all flavonoids tested. naringenin 0-10 interferon gamma Homo sapiens 30-39 19467635-4 2009 Naringenin also inhibited LPS/IFN-gamma-induced iNOS expression and nitric oxide production in glial cells, thus showing the strongest anti-inflammatory activity among all flavonoids tested. Nitric Oxide 68-80 interferon gamma Homo sapiens 30-39 19467635-4 2009 Naringenin also inhibited LPS/IFN-gamma-induced iNOS expression and nitric oxide production in glial cells, thus showing the strongest anti-inflammatory activity among all flavonoids tested. Flavonoids 172-182 interferon gamma Homo sapiens 30-39 19467635-7 2009 Taken together, our results suggest that naringenin may produce an anti-inflammatory effect in LPS/IFN-gamma stimulated glial cells that may be due to its interaction with p38 signalling cascades and the STAT-1 transcription factor. naringenin 41-51 interferon gamma Homo sapiens 99-108 19277466-8 2009 Further, GA inhibited the release of IFN-gamma 24 h but increased the release of TNF-alpha 48 h after incubation with NK cells. Gallium 9-11 interferon gamma Homo sapiens 37-46 18789440-6 2009 Cellular cholesterol content was increased while cholesterol efflux was decreased by IFN-gamma treatment. Cholesterol 49-60 interferon gamma Homo sapiens 85-94 18789440-9 2009 IFN-gamma induced phosphorylation of STAT1 and expression of STAT1alpha in the nucleus, which was inhibited by a JAK inhibitor AG-490. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 127-133 interferon gamma Homo sapiens 0-9 18789440-11 2009 Furthermore, AG-490 and STAT1 siRNA almost compensated the effect of IFN-gamma on ABCA1 expression and cholesterol efflux. Cholesterol 103-114 interferon gamma Homo sapiens 69-78 18789440-12 2009 In conclusion, IFN-gamma may first down-regulate expression of LXRalpha through the JAK/STAT1 signaling pathway and then decrease expression of ABCA1 and cholesterol efflux in THP-1 macrophage-derived foam cells. Cholesterol 154-165 interferon gamma Homo sapiens 15-24 19276371-1 2009 Human mesenchymal stem cells (MSC) strongly repress activated T-cell proliferation through the production of a complex set of soluble factors, including the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO), which is induced by IFN-gamma. Tryptophan 157-167 interferon gamma Homo sapiens 243-252 19403060-5 2009 The findings showed that acute morphine administration significantly reduced CTL responses, lymphocyte proliferation, and IFN-gamma production. Morphine 31-39 interferon gamma Homo sapiens 122-131 19231233-7 2009 IFNgamma-stimulated mast cells showed increase in expressions of proteins and mRNAs of inflammatory cytokines, phosphorylations of MAP kinases, PKCalpha and betaI, JAK1/2, and STAT1 on tyrosine 701 and serine 727. Tyrosine 185-193 interferon gamma Homo sapiens 0-8 19191826-1 2009 AIM: Cerebrospinal fluid (CSF) neopterin production is increased by interferon-gamma stimulation and appears to act as a marker of intrathecal immune activation. Neopterin 31-40 interferon gamma Homo sapiens 68-84 19231233-7 2009 IFNgamma-stimulated mast cells showed increase in expressions of proteins and mRNAs of inflammatory cytokines, phosphorylations of MAP kinases, PKCalpha and betaI, JAK1/2, and STAT1 on tyrosine 701 and serine 727. Serine 202-208 interferon gamma Homo sapiens 0-8 19019580-9 2009 CSF lactate was correlated with CSF concentrations of IL-1beta, IL-6, GM-CSF, G-CSF, IFN-gamma and MIP-1beta. Lactic Acid 4-11 interferon gamma Homo sapiens 85-94 19187273-5 2009 We also found that IFN-gamma and IL-6 can induce BLyS expression on MM cells, while after the treatment of BAY11-7082, an IkB-alpha phosphorylation inhibitor, IFN-gamma induced up regulation of BLyS was completely inhibited, suggesting that nuclear factor kappaB (NF-kappaB) might be involved in the mechanism of the regulation of BLyS levels in response to cytokines. 3-(4-methylphenylsulfonyl)-2-propenenitrile 107-117 interferon gamma Homo sapiens 19-28 19266489-2 2009 Here, using a sensitive cultured IFN-gamma ELISPOT assay, we show that 50% (15 out of 30) of healthy, HIV-1/2-uninfected volunteers who received pTHr.HIVA DNA prime-modified vaccinia virus Ankara. pthr 145-149 interferon gamma Homo sapiens 33-42 19187273-5 2009 We also found that IFN-gamma and IL-6 can induce BLyS expression on MM cells, while after the treatment of BAY11-7082, an IkB-alpha phosphorylation inhibitor, IFN-gamma induced up regulation of BLyS was completely inhibited, suggesting that nuclear factor kappaB (NF-kappaB) might be involved in the mechanism of the regulation of BLyS levels in response to cytokines. 3-(4-methylphenylsulfonyl)-2-propenenitrile 107-117 interferon gamma Homo sapiens 159-168 19176616-8 2009 IFN-gamma treatment of SINV-infected differentiated CSM14.1 cells, AP-7 olfactory neuronal cells, and primary dorsal root ganglia neurons triggered prolonged Stat-1 Tyr(701) phosphorylation, Stat-1 Ser(727) phosphorylation, and transient Stat-5 phosphorylation. Tyrosine 165-168 interferon gamma Homo sapiens 0-9 19181373-9 2009 RESULTS: To the extent that children with asthma perceived low support from their parents, children were more resistant to hydrocortisone"s anti-inflammatory effects on IL-5 and IFN-gamma production and had higher circulating levels of eosinophil cationic protein. Hydrocortisone 123-137 interferon gamma Homo sapiens 178-187 19214125-2 2009 The cytokine interferon-gamma, which seems to play an important role in HIV infection, induces neopterin formation and in parallel also tryptophan degradation by the enzyme indoleamine 2,3-dioxygenase. Neopterin 95-104 interferon gamma Homo sapiens 13-29 19214125-2 2009 The cytokine interferon-gamma, which seems to play an important role in HIV infection, induces neopterin formation and in parallel also tryptophan degradation by the enzyme indoleamine 2,3-dioxygenase. Tryptophan 136-146 interferon gamma Homo sapiens 13-29 19176616-8 2009 IFN-gamma treatment of SINV-infected differentiated CSM14.1 cells, AP-7 olfactory neuronal cells, and primary dorsal root ganglia neurons triggered prolonged Stat-1 Tyr(701) phosphorylation, Stat-1 Ser(727) phosphorylation, and transient Stat-5 phosphorylation. Serine 198-201 interferon gamma Homo sapiens 0-9 19330924-3 2009 Pro-inflammatory cytokine interferon-gamma and related biochemical pathways like tryptophan degradation by indoleamine 2,3-dioxygenase and neopterin formation are closely associated with the pathogenesis of such disorders. Tryptophan 81-91 interferon gamma Homo sapiens 26-42 18845337-6 2009 Based on our previous findings that AML cells produce IFN-alpha upon electroporation with the synthetic double-stranded (ds)RNA polyriboinosinic polyribocytidylic acid (poly(I:C)), we hypothesized that dsRNA-loaded tumor cells provide both signals to elicit an NK cell-driven IFN-gamma production. polyriboinosinic 128-144 interferon gamma Homo sapiens 276-285 18845337-6 2009 Based on our previous findings that AML cells produce IFN-alpha upon electroporation with the synthetic double-stranded (ds)RNA polyriboinosinic polyribocytidylic acid (poly(I:C)), we hypothesized that dsRNA-loaded tumor cells provide both signals to elicit an NK cell-driven IFN-gamma production. Poly C 145-167 interferon gamma Homo sapiens 276-285 19330924-3 2009 Pro-inflammatory cytokine interferon-gamma and related biochemical pathways like tryptophan degradation by indoleamine 2,3-dioxygenase and neopterin formation are closely associated with the pathogenesis of such disorders. Neopterin 139-148 interferon gamma Homo sapiens 26-42 19159656-7 2009 Generally, suppression of IFN-gamma by PM(0.5)-extracts was stronger than those of IL-4. Promethium 39-41 interferon gamma Homo sapiens 26-35 19159656-9 2009 Contrary, LPCi-extracts exerted maximum IFN-gamma suppression based either on air volume or regarding PM(0.5)-adsorbed PAH. lpci 10-14 interferon gamma Homo sapiens 40-49 19159656-9 2009 Contrary, LPCi-extracts exerted maximum IFN-gamma suppression based either on air volume or regarding PM(0.5)-adsorbed PAH. p-Aminohippuric Acid 119-122 interferon gamma Homo sapiens 40-49 19252299-3 2009 Here we demonstrate that the HDAC inhibitor, MS-275, can rescue the IFN-gamma inducibility of human leukocyte antigen (HLA)-DR in non-small cell lung cancer cells. entinostat 45-51 interferon gamma Homo sapiens 68-77 18945560-3 2009 IFN-gamma induces expression of the enzyme indoleamine 2,3-dioxygenase (IDO), resulting in the degradation of intracellular pools of tryptophan, thereby depriving the organism of this essential growth nutrient. Tryptophan 133-143 interferon gamma Homo sapiens 0-9 18945560-4 2009 The anti-chlamydial effects of IFN-gamma can be reversed by the addition of exogenous tryptophan. Tryptophan 86-96 interferon gamma Homo sapiens 31-40 19273625-6 2009 While enhancing Th17 cytokine expression mainly through EP2, PGE2 differentially regulates interferon (IFN)-gamma production and inhibits production of the antiinflammatory cytokine IL-10 in Th17 cells predominantly through EP4. Dinoprostone 61-65 interferon gamma Homo sapiens 91-113 18677478-6 2009 Induction of NY-ESO-1 expression on tumor targets using the demethylating agent 5-aza-2"-deoxycytidine (alone or in combination with the histone deacetylase inhibitor depsipeptide) resulted in enhanced interferon-gamma secretion by the TCR-transduced PBL on culture with treated targets. Decitabine 80-102 interferon gamma Homo sapiens 202-218 19135025-1 2009 In the present study, we found that (-)-epigallocatechin-3-gallate (EGCG) significantly up-regulated the mRNA expression of the Th1/Th2 cytokines including IL-2, IFN-gamma, IL-5 and IL-13 in Jurkat T cells. epigallocatechin gallate 36-66 interferon gamma Homo sapiens 162-171 19135025-1 2009 In the present study, we found that (-)-epigallocatechin-3-gallate (EGCG) significantly up-regulated the mRNA expression of the Th1/Th2 cytokines including IL-2, IFN-gamma, IL-5 and IL-13 in Jurkat T cells. epigallocatechin gallate 68-72 interferon gamma Homo sapiens 162-171 18677478-6 2009 Induction of NY-ESO-1 expression on tumor targets using the demethylating agent 5-aza-2"-deoxycytidine (alone or in combination with the histone deacetylase inhibitor depsipeptide) resulted in enhanced interferon-gamma secretion by the TCR-transduced PBL on culture with treated targets. Depsipeptides 167-179 interferon gamma Homo sapiens 202-218 18979063-7 2009 Our results showed that freshly isolated CBDCs, similar to cord blood monocyte derived DCs, were poor inducers of IFN-gamma secretion while they increased the induction of IL-4 production by T cells in comparison with PBDCs. cbdcs 41-46 interferon gamma Homo sapiens 114-123 18972195-1 2009 BACKGROUND: IL-12/23-interferon-gamma circuit enhances reactive oxygen species (ROS) synthesis in macrophage to attack intracellular pathogens such as mycobacteria and salmonella. Reactive Oxygen Species 55-78 interferon gamma Homo sapiens 21-37 19197941-5 2009 COX-2 expression and PGE(2) production by MSC were not constitutive, but were induced by IFN-gamma and TNF-alpha secreted by activated Vgamma9Vdelta2 T cells. Prostaglandins E 21-24 interferon gamma Homo sapiens 89-98 18972195-1 2009 BACKGROUND: IL-12/23-interferon-gamma circuit enhances reactive oxygen species (ROS) synthesis in macrophage to attack intracellular pathogens such as mycobacteria and salmonella. Reactive Oxygen Species 80-83 interferon gamma Homo sapiens 21-37 19254676-8 2009 The levels of IFN-gamma and the ratios of IFN-gamma:IL-4 were significantly decreased with atorvastatin treatment both in vivo and in vitro, whereas levels of IL-4 did not differ significantly. Atorvastatin 91-103 interferon gamma Homo sapiens 14-23 19254676-8 2009 The levels of IFN-gamma and the ratios of IFN-gamma:IL-4 were significantly decreased with atorvastatin treatment both in vivo and in vitro, whereas levels of IL-4 did not differ significantly. Atorvastatin 91-103 interferon gamma Homo sapiens 42-51 18787531-0 2009 Iron chelators and hypoxia mimetics inhibit IFNgamma-mediated Jak-STAT signaling. Iron 0-4 interferon gamma Homo sapiens 44-52 19335688-5 2009 Furthermore, the enhanced expression of CD208 in the perinuclear lesions of IFN-gamma-/TPA-stimulated keratinocytes was observed in vitro. Tetradecanoylphorbol Acetate 87-90 interferon gamma Homo sapiens 76-85 18787531-2 2009 We have previously shown the treatment of cells with chelators which preferentially bind iron inhibits IFNgamma-mediated induction of IFN regulatory factor 1 in endothelial cells. Iron 89-93 interferon gamma Homo sapiens 103-111 18787531-7 2009 Furthermore, inhibition of IFNgamma signaling and downregulation of IFNgammaR1 was also mediated by nonmetal-binding hypoxia mimetics and reduced oxygen tensions. Oxygen 146-152 interferon gamma Homo sapiens 27-35 19095736-5 2009 However, when PBMC were stimulated with IFN-alpha, adenosine did not decrease, but synergistically increased, the IFN-gamma production of NK cells. Adenosine 51-60 interferon gamma Homo sapiens 114-123 19095736-0 2009 Adenosine and IFN-{alpha} synergistically increase IFN-gamma production of human NK cells. Adenosine 0-9 interferon gamma Homo sapiens 51-60 19196072-5 2009 We found that downregulation of claudin-1 (CLDN1) induced by IFN-gamma resulted in disruption of barrier function as demonstrated by measurement of transepithelial electrical resistance and dextran permeability. Dextrans 190-197 interferon gamma Homo sapiens 61-70 19095736-3 2009 Here, we show that the adenosine A(3) receptor agonist iodobenzyl methylcarboxamidoadenosine potently inhibited proliferation, IFN-gamma production, and cytotoxicity of activated human lymphoid cells. iodobenzyl methylcarboxamidoadenosine 55-92 interferon gamma Homo sapiens 127-136 19199539-1 2009 Interferon-gamma (IFN-gamma) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-gamma transcription. Cyclic AMP 120-124 interferon gamma Homo sapiens 175-184 19041327-7 2009 Quantitative PCR reveals that TSA enhances MHC II activation and collagen repression by IFN-gamma. trichostatin A 30-33 interferon gamma Homo sapiens 88-97 19071156-4 2009 This study demonstrated that prolonged treatment with IFN-gamma induced cellular senescence in HUVECs, as confirmed by G0/G1 cell cycle arrest, up-regulation of p53 and p21 protein levels, increased SA-beta-gal staining, and the accumulation of phospho-H(2)AX foci. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid 199-210 interferon gamma Homo sapiens 54-63 19071156-6 2009 IFN-gamma treatment increased ROS production, and an antioxidant, N-acetylcysteine, inhibited IFN-gamma-induced cellular senescence. ros 30-33 interferon gamma Homo sapiens 0-9 19071156-6 2009 IFN-gamma treatment increased ROS production, and an antioxidant, N-acetylcysteine, inhibited IFN-gamma-induced cellular senescence. Acetylcysteine 66-82 interferon gamma Homo sapiens 94-103 19002565-6 2009 Transduced islets were viable after incubation with the cocktail of TNF-alpha, IL-1beta and IFN-gamma, as evidenced by insulin release in response to glucose concentration. Glucose 150-157 interferon gamma Homo sapiens 92-101 18662276-9 2009 IFN-gamma- and TNF-alpha-mediated apoptosis was reduced by lamivudine treatment in HepG2.2.15 cells. Lamivudine 59-69 interferon gamma Homo sapiens 0-9 19238023-0 2009 Interferon-gamma down-regulates heat shock protein 27 of pancreatic cancer cells and helps in the cytotoxic effect of gemcitabine. gemcitabine 118-129 interferon gamma Homo sapiens 0-16 19254978-10 2009 Considering age as a binary variable (<4 and >/=4 years of age), a significantly higher concentration of phytohaemagglutinin-produced interferon-gamma was observed in older children with both QuantiFERON-TB Gold and QuantiFERON-TB In-Tube. tb gold 210-217 interferon gamma Homo sapiens 140-156 19084598-0 2009 Interferon-gamma increases expression of the di/tri-peptide transporter, h-PEPT1, and dipeptide transport in cultured human intestinal monolayers. Dipeptides 86-95 interferon gamma Homo sapiens 0-16 19084598-3 2009 This study was conducted to determine the effects of the inflammatory cytokine interferon-gamma (IFN-gamma) on h-PEPT1 mediated dipeptide absorption. Dipeptides 128-137 interferon gamma Homo sapiens 79-95 19084598-3 2009 This study was conducted to determine the effects of the inflammatory cytokine interferon-gamma (IFN-gamma) on h-PEPT1 mediated dipeptide absorption. Dipeptides 128-137 interferon gamma Homo sapiens 97-106 19084598-5 2009 The effective apical-to-basolateral permeability (P(eff)) of glycylsarcosine (Gly-Sar) was measured following incubation with IFN-gamma or control media. glycylsarcosine 61-76 interferon gamma Homo sapiens 126-135 19084598-5 2009 The effective apical-to-basolateral permeability (P(eff)) of glycylsarcosine (Gly-Sar) was measured following incubation with IFN-gamma or control media. glycylsarcosine 78-85 interferon gamma Homo sapiens 126-135 19084598-8 2009 IFN-gamma 50 ng/ml increased Gly-Sar P(eff) 28.6% compared to controls (p=0.03). Glycine 29-32 interferon gamma Homo sapiens 0-9 19084598-10 2009 In controls and IFN-gamma treated cells, concentration dependent transport was seen with escalating concentrations of Gly-Sar. Glycine 118-121 interferon gamma Homo sapiens 16-25 19084598-12 2009 In summary, IFN-gamma increases h-PEPT1 expression and permeation of the dipeptide Gly-Sar in Caco-2 monolayers. Dipeptides 73-82 interferon gamma Homo sapiens 12-21 19084598-12 2009 In summary, IFN-gamma increases h-PEPT1 expression and permeation of the dipeptide Gly-Sar in Caco-2 monolayers. Glycine 83-86 interferon gamma Homo sapiens 12-21 19144391-0 2009 Effect of chromium on the level of IL-12 and IFN-gamma in occupationally exposed workers. Chromium 10-18 interferon gamma Homo sapiens 45-54 19144391-10 2009 However, IFN-gamma level have a significant positive correlation between blood chromium level (r=0.833, t=6.3872, P 0.05) and exposure time (in years) (r=0.8916, t=8.3540, P 0.05) of the occupationally exposed workers. Chromium 79-87 interferon gamma Homo sapiens 9-18 19195485-3 2009 ASB16165, which has an IC50 value of 15 nM for human PDE7A, suppressed IL-12-induced IFN-gamma production by T lymphoblasts which have been prepared by stimulating mouse T cells with anti-CD3 antibody. 1-cyclohexyl-N-(6-(4-hydroxy-1-piperidinyl)-3-pyridinyl)-3-methyl-1H-thieno(2,3-c)pyrazole-5-carboxamide 0-8 interferon gamma Homo sapiens 85-94 19281537-0 2009 An alkaloid extract of Evanta, traditionally used as anti-Leishmania agent in Bolivia, inhibits cellular proliferation and interferon-gamma production in polyclonally activated cells. Alkaloids 3-11 interferon gamma Homo sapiens 123-139 19265500-13 2009 Decreased Tg production in the presence of KI excess and IFN-gamma could explain the development of hypothyroidism after adding iodide in a diet of subjects that already have lymphocytic infiltration and/or mild inflammation in the thyroid gland. Iodides 128-134 interferon gamma Homo sapiens 57-66 19250549-9 2009 CONCLUSION: IFN-gamma-producing RD1-specific T cells, as measured in the T-SPOT.TB assay, may be directly related to bacterial load in patients undergoing treatment for pulmonary TB. Terbium 80-82 interferon gamma Homo sapiens 12-21 19103272-6 2009 However, PMBE pre-treatment (40 microg/ml for 24 h) significantly inhibited IFN-gamma-induced ICAM-1 expression. pmbe 9-13 interferon gamma Homo sapiens 76-85 18942150-2 2009 In this article, a site-selective tyrosinase (TR)-catalyzed protein A strategy for antibody immobilization was developed to enhance the sensitivity of ELISA in poly-(methyl methacrylate) (PMMA) microchannels for interferon-gamma (IFN-gamma) assay. Polymethyl Methacrylate 160-186 interferon gamma Homo sapiens 212-228 18942150-2 2009 In this article, a site-selective tyrosinase (TR)-catalyzed protein A strategy for antibody immobilization was developed to enhance the sensitivity of ELISA in poly-(methyl methacrylate) (PMMA) microchannels for interferon-gamma (IFN-gamma) assay. Polymethyl Methacrylate 160-186 interferon gamma Homo sapiens 230-239 18942150-2 2009 In this article, a site-selective tyrosinase (TR)-catalyzed protein A strategy for antibody immobilization was developed to enhance the sensitivity of ELISA in poly-(methyl methacrylate) (PMMA) microchannels for interferon-gamma (IFN-gamma) assay. Polymethyl Methacrylate 188-192 interferon gamma Homo sapiens 212-228 18942150-2 2009 In this article, a site-selective tyrosinase (TR)-catalyzed protein A strategy for antibody immobilization was developed to enhance the sensitivity of ELISA in poly-(methyl methacrylate) (PMMA) microchannels for interferon-gamma (IFN-gamma) assay. Polymethyl Methacrylate 188-192 interferon gamma Homo sapiens 230-239 19201907-7 2009 SP children had a significantly reduced proportion of IFN-gamma(+) NK cells and cognate intracellular IFN-gamma levels, which was more pronounced in CMV-coinfected subjects. sp 0-2 interferon gamma Homo sapiens 54-63 19201907-7 2009 SP children had a significantly reduced proportion of IFN-gamma(+) NK cells and cognate intracellular IFN-gamma levels, which was more pronounced in CMV-coinfected subjects. sp 0-2 interferon gamma Homo sapiens 102-111 19073595-3 2009 C3H7 antigen expression in epithelial monolayers was significantly increased by treatment with proinflammatory cytokine interferon-gamma or a combination of interferon-gamma and tumor necrosis factor-alpha. c3h7 0-4 interferon gamma Homo sapiens 120-136 19073595-3 2009 C3H7 antigen expression in epithelial monolayers was significantly increased by treatment with proinflammatory cytokine interferon-gamma or a combination of interferon-gamma and tumor necrosis factor-alpha. c3h7 0-4 interferon gamma Homo sapiens 157-205 18776133-0 2009 IFN-gamma reverses IL-2- and IL-4-mediated T-cell steroid resistance. Steroids 50-57 interferon gamma Homo sapiens 0-9 19095032-6 2009 Formulation of TA-CIN with GPI-0100 enhanced the production of E7-specific, interferon gamma producing CD8(+) T cell precursors by 20-fold. GPI0100 27-35 interferon gamma Homo sapiens 63-92 18776133-6 2009 Importantly, addition of IFN-gamma to the IL-2/IL-4 combination restored GCRalpha nuclear translocation in response to DEX. Dexamethasone 119-122 interferon gamma Homo sapiens 25-34 18776133-7 2009 Furthermore, DEX-induced mitogen-activated protein kinase (MAPK) phosphatase-1 induction, used as a readout for corticosteroid-induced transactivation, was significantly greater (P < 0.05) in media and IL-2/IL-4/IFN-gamma-treated conditions compared with IL-2/IL-4-treated cells. Dexamethasone 13-16 interferon gamma Homo sapiens 215-224 18776133-9 2009 The presence of the p38 MAPK inhibitor, SB203580, or IFN-gamma inhibited p38 MAPK phosphorylation and enhanced GCRalpha nuclear translocation in response to DEX. Dexamethasone 157-160 interferon gamma Homo sapiens 53-62 18556000-1 2009 Neopterin is released from human monocyte-derived macrophages upon stimulation with interferon-gamma and is a sensitive indicator for cellular immune activation. Neopterin 0-9 interferon gamma Homo sapiens 84-100 19236347-0 2009 The adrenal steroid response during tuberculosis and its effects on the mycobacterial-driven IFN-gamma production of patients and their household contacts. Steroids 12-19 interferon gamma Homo sapiens 93-102 19236347-9 2009 In contrast, addition of DHEA to cultures of cells from HHCs resulted in increased IFN-gamma levels. Dehydroepiandrosterone 25-29 interferon gamma Homo sapiens 83-92 19027720-6 2009 Furthermore, BIRB796 and compound 2 inhibited the production of TNF-alpha in THP-1 monocytes and the IL-12/IL-18-induced production of interferon-gamma in human T-cells with similar potencies. doramapimod 13-20 interferon gamma Homo sapiens 135-151 18586252-5 2009 High glucose also enhanced IFN gamma-induced priming effect on lipopolysaccharide (LPS)-stimulated MMP-1 secretion. Glucose 5-12 interferon gamma Homo sapiens 27-36 19016700-7 2009 However, in the presence of a strong, prototypic proinflammatory stimulus (IFN-gamma), K(D)PT significantly stimulated HF melanin content and melanocyte dendrite formation in situ. Melanins 122-129 interferon gamma Homo sapiens 75-84 19040353-4 2009 Mitogen stimulation induced expression of IFN-gamma, GTP cyclohydrolase I (GCH-I), and indoleamine (2,3)-dioxygenase (IDO) resulting in enhanced neopterin formation and tryptophan degradation by HIV-infected and control PBMCs. Neopterin 145-154 interferon gamma Homo sapiens 42-51 19040353-4 2009 Mitogen stimulation induced expression of IFN-gamma, GTP cyclohydrolase I (GCH-I), and indoleamine (2,3)-dioxygenase (IDO) resulting in enhanced neopterin formation and tryptophan degradation by HIV-infected and control PBMCs. Tryptophan 169-179 interferon gamma Homo sapiens 42-51 19040353-5 2009 IFN-gamma concentrations correlated with neopterin levels and tryptophan degradation. Neopterin 41-50 interferon gamma Homo sapiens 0-9 19040353-5 2009 IFN-gamma concentrations correlated with neopterin levels and tryptophan degradation. Tryptophan 62-72 interferon gamma Homo sapiens 0-9 19154420-7 2009 Increases in drug efflux transporter expression, in response to cytokines, resulted in reduced cellular accumulation of digoxin [decrease of 17% and 26% for IL-2 and interferon-gamma (IFNgamma) respectively] and saquinavir (decrease of 28% and 30% for IL-2 and IFNgamma respectively). Digoxin 120-127 interferon gamma Homo sapiens 166-182 19154420-7 2009 Increases in drug efflux transporter expression, in response to cytokines, resulted in reduced cellular accumulation of digoxin [decrease of 17% and 26% for IL-2 and interferon-gamma (IFNgamma) respectively] and saquinavir (decrease of 28% and 30% for IL-2 and IFNgamma respectively). Digoxin 120-127 interferon gamma Homo sapiens 261-269 18594817-12 2009 Furthermore, the CD3(+) T cells co-cultured with topotecan treated U-87 and autologous GBM tumor cells showed a significant increase in expression in IFN-gamma, a key cytokine produced by activated T cells, and accordingly enhanced tumor cytotoxicity. Topotecan 49-58 interferon gamma Homo sapiens 150-159 19019941-0 2009 Inhibitory effect of rapamycin and dexamethasone on production of IL-17 and IFN-gamma in Vogt-Koyanagi-Harada patients. Dexamethasone 35-48 interferon gamma Homo sapiens 76-85 19019941-1 2009 AIMS: To evaluate the effect of rapamycin (RAPA) and dexamethasone (DEX) on the production of IL-17 and IFN-gamma by peripheral blood mononuclear cells (PBMCs) from Vogt-Koyanagi-Harada (VKH) patients and healthy individuals. Dexamethasone 68-71 interferon gamma Homo sapiens 104-113 19019941-7 2009 DEX inhibited the production of both IL-17 and IFN-gamma by approximately 70%. Dexamethasone 0-3 interferon gamma Homo sapiens 47-56 19019941-8 2009 CONCLUSIONS: This study indicates that both RAPA and DEX inhibit the production of IL-17 and IFN-gamma by PBMCs. Sirolimus 44-48 interferon gamma Homo sapiens 93-102 19019941-8 2009 CONCLUSIONS: This study indicates that both RAPA and DEX inhibit the production of IL-17 and IFN-gamma by PBMCs. Dexamethasone 53-56 interferon gamma Homo sapiens 93-102 19091593-0 2009 Effect of 1,25 dihydroxyvitamin D3 on intracellular IFN-gamma and TNF-alpha positive T cell subsets in pulmonary tuberculosis. Calcitriol 10-34 interferon gamma Homo sapiens 52-61 19100838-7 2009 Real time RT-PCR analysis confirmed that IFN-gamma gene expression was up-regulated in organs of cod injected with the dsRNA polyinosinic:polycytidylic acid (poly I:C), which is a strong inducer of type I IFNs. Poly I-C 125-156 interferon gamma Homo sapiens 41-50 19138532-3 2009 The results revealed that DEX nonspecifically and dose-dependently inhibited the production of 12 cytokines (IL-2, IFN-gamma, TNF-alpha, IL-8, IL-1beta, IL-17, IL-4, IL-5, IL-6, IL-10, IL-13, and G-CSF). Dexamethasone 26-29 interferon gamma Homo sapiens 115-124 19100838-7 2009 Real time RT-PCR analysis confirmed that IFN-gamma gene expression was up-regulated in organs of cod injected with the dsRNA polyinosinic:polycytidylic acid (poly I:C), which is a strong inducer of type I IFNs. Poly I 158-164 interferon gamma Homo sapiens 41-50 19100838-8 2009 Injection of cod with formalin-killed Vibrio anguillarum also increased IFN-gamma expression in head kidney, but to a much lesser extent than poly I:C. The gene expression results thus indicate a role for IFN-gamma in innate immune response against both virus and bacteria in Atlantic cod. Formaldehyde 22-30 interferon gamma Homo sapiens 72-81 19100838-8 2009 Injection of cod with formalin-killed Vibrio anguillarum also increased IFN-gamma expression in head kidney, but to a much lesser extent than poly I:C. The gene expression results thus indicate a role for IFN-gamma in innate immune response against both virus and bacteria in Atlantic cod. Formaldehyde 22-30 interferon gamma Homo sapiens 205-214 20107534-1 2009 BACKGROUND: We previously reported that IFN-gamma producing T cell responses induced by the combined therapy of DNA vaccine and lamivudine for one year are important for the induction of sustained virological response (SVR). Lamivudine 128-138 interferon gamma Homo sapiens 40-49 18957935-5 2009 The results show that helper T cells from 5 out of 13 chagasic patients specifically produced interferon-gamma after exposure to the KMP-11 antigen, whereas healthy donors and non-chagasic cardiopathic patients did not respond. kmp-11 133-139 interferon gamma Homo sapiens 94-110 19015047-0 2009 Dehydroepiandrosterone inhibits CD40/CD40L expression on human umbilical vein endothelial cells induced by interferon gamma. Dehydroepiandrosterone 0-22 interferon gamma Homo sapiens 107-123 19015047-3 2009 The major purpose of our present work was to assess whether DHEA could decrease the expression of CD40 and CD40L on human umbilical vein endothelial cells (HUVECs) induced by interferon gamma (IFN-gamma). Dehydroepiandrosterone 60-64 interferon gamma Homo sapiens 175-202 19015047-4 2009 We found that DHEA inhibited IFN-gamma-induced expression of CD40 and CD40L in a dose-dependent manner. Dehydroepiandrosterone 14-18 interferon gamma Homo sapiens 29-38 19015047-5 2009 Moreover, DHEA inhibited IFN-gamma-induced activation of extracellular signal regulated kinase (ERK1/2). Dehydroepiandrosterone 10-14 interferon gamma Homo sapiens 25-34 19015047-7 2009 These findings suggest that DHEA can inhibit the expression of molecules involved in the inflammatory process in endothelial cells activated with IFN-gamma. Dehydroepiandrosterone 28-32 interferon gamma Homo sapiens 146-155 19139565-7 2009 Stimulation of 1alpha25VitD3-induced IL-10-secreting Treg with TLR9 agonists, CpG oligonucleotides, resulted in decreased IL-10 and IFN-gamma synthesis and a concurrent loss of regulatory function, but, unexpectedly, increased IL-4 synthesis. Oligonucleotides 82-98 interferon gamma Homo sapiens 132-141 19041714-8 2009 The host cell cAMP pathway triggered by Brucella could be responsible for this defect, CBP/P300 mobilization by phosphorylated CREB (P-CREB) disrupting the IFNgamma-induced STAT1-CBP/P300 association, required for a normal response of macrophages to IFNgamma. Cyclic AMP 14-18 interferon gamma Homo sapiens 156-164 19434841-4 2009 We performed a flexible molecular docking analysis between a set of polyphenols previously demonstrated to have the highest binding affinity and both the constitutive (from deposited PDB structures) and homology modeled active subunits of the IFN-gamma inducible proteasome, to provide insight into the possible mechanism of interaction. Polyphenols 68-79 interferon gamma Homo sapiens 243-252 19229322-5 2009 Our present findings demonstrate a rapid and HMB-PP-dependent crosstalk between Vgamma9/Vdelta2 T cells and autologous monocytes that results in the immediate production of inflammatory mediators including the cytokines interleukin (IL)-6, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and oncostatin M (OSM); the chemokines CCL2, CXCL8, and CXCL10; and TNF-related apoptosis-inducing ligand (TRAIL). 4-hydroxy-3-methylbut-2-enyl pyrophosphate 45-51 interferon gamma Homo sapiens 240-262 19274383-8 2009 However, IND patients displayed a positive correlation between IL-10 and IFN-gamma levels in serum, while CARD patients showed no such correlation, indicating an uncontrolled inflammatory response in CARD patients. indole 9-12 interferon gamma Homo sapiens 73-82 18803615-2 2009 The newly developed interferon-gamma (IFN-gamma)-based QuantiFERON((R))-TB Gold In-Tube test (QFT-G) seems to be superior to the other available tests. tb gold 72-79 interferon gamma Homo sapiens 38-47 18803615-8 2009 RESULTS: Compared with the pre-dialysis level, there was an obvious reduction in the IFN-gamma production level (in response to the TB-antigen cocktails) after the HD process (P=0.00). Terbium 132-134 interferon gamma Homo sapiens 85-94 18803615-0 2009 Acute effect of low-flux hemodialysis process on the results of the interferon-gamma-based QuantiFERON-TB Gold In-Tube test in end-stage renal disease patients. tb gold 103-110 interferon gamma Homo sapiens 68-84 18803615-2 2009 The newly developed interferon-gamma (IFN-gamma)-based QuantiFERON((R))-TB Gold In-Tube test (QFT-G) seems to be superior to the other available tests. tb gold 72-79 interferon gamma Homo sapiens 20-36 19072554-5 2009 Kinetic analysis showed that a decrease in the serum creatinine level during the acute phase of illness was often accompanied by an increase in the magnitude of IFN-gamma-producing T cells. Creatinine 53-63 interferon gamma Homo sapiens 161-170 18996444-9 2009 Moreover, IFN-gamma/LPS-induced dopaminergic cell death was augmented by zinc protoporphyrin IX, an HO-1 inhibitor. zinc protoporphyrin 73-95 interferon gamma Homo sapiens 10-19 19136895-11 2009 In addition, in the presence of CP-690,550, the interferon-[gamma] production capacity of peripheral blood mononuclear cells was reduced by 39% (median) compared with predose baseline (P=0.01). tofacitinib 32-38 interferon gamma Homo sapiens 48-65 18930085-3 2009 GSL-liposomes remarkably enhanced the production of IFN-gamma from splenocytes in vitro and this enhancement depended on the content of the pH-sensitive lipid dioleoyl-phosphoethanolamine (DOPE) in the liposomes. dioleoyl phosphoethanolamine 159-187 interferon gamma Homo sapiens 52-61 18942710-12 2009 Furthermore, data revealed that DC-NK cell crosstalk improves slanDC-mediated differentiation of naive CD4+ T lymphocytes into IFN-gamma-producing Th1 cells. slandc 62-68 interferon gamma Homo sapiens 127-136 18930085-3 2009 GSL-liposomes remarkably enhanced the production of IFN-gamma from splenocytes in vitro and this enhancement depended on the content of the pH-sensitive lipid dioleoyl-phosphoethanolamine (DOPE) in the liposomes. 1,2-dielaidoylphosphatidylethanolamine 189-193 interferon gamma Homo sapiens 52-61 19086992-4 2009 RESULTS: After stimulation by polyI:C, human uNK cells interact with autologous uterine macrophages and produce interferon-gamma in an NKG2D-dependent manner. Poly I-C 30-37 interferon gamma Homo sapiens 112-128 18486134-7 2009 RESULTS: We documented a significant association between IP-10, IFN-gamma, IL-4 and RPR by both AA- and ADP-induced platelet aggregation after adjustment for age, sex, cardiovascular risk factors, ejection fraction, BMI, vWF and CRP. Adenosine Diphosphate 104-107 interferon gamma Homo sapiens 64-73 19572476-3 2009 The aim of the present study was to assess the influence of nickel-specific IFN-gamma secretion (marker of Th1 and Tc1 activity) and IL-5 secretion (Th2 and Tc2) on the clinical outcome (patch test score) in nickel-allergic patients. Nickel 60-66 interferon gamma Homo sapiens 76-85 19572476-3 2009 The aim of the present study was to assess the influence of nickel-specific IFN-gamma secretion (marker of Th1 and Tc1 activity) and IL-5 secretion (Th2 and Tc2) on the clinical outcome (patch test score) in nickel-allergic patients. Nickel 208-214 interferon gamma Homo sapiens 76-85 19594946-14 2009 In vitro corticosteroid sensitivity assay indicated that PHA-stimulated tumour necrosis factor-alpha (TNF-alpha), IL-12 and interferon-gamma (IFN-gamma) secretion was significantly inhibited by 10-6 M Dexamethasone in all controls and SS patients, compared with that in SR group, which confirms patient classification as SR and SS by disease activity index (SLEDAI) score. Dexamethasone 201-214 interferon gamma Homo sapiens 124-140 19594946-14 2009 In vitro corticosteroid sensitivity assay indicated that PHA-stimulated tumour necrosis factor-alpha (TNF-alpha), IL-12 and interferon-gamma (IFN-gamma) secretion was significantly inhibited by 10-6 M Dexamethasone in all controls and SS patients, compared with that in SR group, which confirms patient classification as SR and SS by disease activity index (SLEDAI) score. Dexamethasone 201-214 interferon gamma Homo sapiens 142-151 19348124-2 2009 The aim of this research is to evaluate the response of HAS gene expression and the related protein synthesis in fibroblasts after treatment with TNFalpha, IFNgamma and TGF1beta and to assess the potential protective effect of increased hyaluronan (HA) synthesis during oxidative stress. Hyaluronic Acid 56-58 interferon gamma Homo sapiens 156-164 19076726-5 2009 The sensitivity of CTL to adenosine analogues was characterized by cAMP induction, interferon-gamma production and cytotoxicity. Adenosine 26-35 interferon gamma Homo sapiens 83-99 18625298-7 2009 We found that fluoxetine restored T cell proliferation and interleukin-2, interferon-gamma and tumor necrosis factor-alpha production by compensatory mechanisms. Fluoxetine 14-24 interferon gamma Homo sapiens 74-122 18849615-0 2009 Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production. diesel 47-53 interferon gamma Homo sapiens 119-135 19519446-13 2009 The inhibitory effects of curcumin on major inflammatory mechanisms like COX-2, LOX, TNF-alpha, IFN-gamma, NF-kappaB and its unrivalled safety profile suggest that it has bright prospects in the treatment of IBD. Curcumin 26-34 interferon gamma Homo sapiens 96-105 19555208-7 2009 Interestingly, ZOL augmented the allostimulatory activity of DC on naive CD4(++)CD45(+)RA(++) T cells in terms of their proliferation and interferon-gamma production. Zoledronic Acid 15-18 interferon gamma Homo sapiens 138-154 19589615-7 2009 Accordingly, slanDC depletion completely abrogated the capacity to produce both IL-12p70 and IFNgamma in response to LPS plus IL-2 by slanDC-containing NK cells. slandc 13-19 interferon gamma Homo sapiens 93-101 19589615-7 2009 Accordingly, slanDC depletion completely abrogated the capacity to produce both IL-12p70 and IFNgamma in response to LPS plus IL-2 by slanDC-containing NK cells. slandc 134-140 interferon gamma Homo sapiens 93-101 18952005-12 2009 However, LLDT-8 significantly reduced IFN-gamma-expressing T cell percentages and IFN-gamma mRNA transcription in PHA-activated T cells. 5alpha-Hydroxytriptolide 9-15 interferon gamma Homo sapiens 38-47 18952005-12 2009 However, LLDT-8 significantly reduced IFN-gamma-expressing T cell percentages and IFN-gamma mRNA transcription in PHA-activated T cells. 5alpha-Hydroxytriptolide 9-15 interferon gamma Homo sapiens 82-91 18849615-0 2009 Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production. Formaldehyde 75-87 interferon gamma Homo sapiens 119-135 18849615-8 2009 Treatment with N-acetylcysteine reversed the augmented Gadd45a mRNA response and caused the suppressed IFN-gamma mRNA response to recover. Acetylcysteine 15-31 interferon gamma Homo sapiens 103-112 19897074-3 2009 Recently, new factors regarding glial cell line-derived neurotorophic factor, tumor necrosis factor-alpha, and interferon-gamma have also been associated with methamphetamine-induced neurotoxicity. Methamphetamine 159-174 interferon gamma Homo sapiens 111-127 19309553-8 2009 The effects of calcitriol incubation were: 1) reduced IFN-gamma (p=0.024) and increased IL-10 (p=0.06) production in UC patients; 2) reduced TNF-alpha production in CD (p=0.032); 3) no significant effects in HC. Calcitriol 15-25 interferon gamma Homo sapiens 54-63 19321044-0 2009 Ebastine increases IFN-gamma production in patients with persistent allergic rhinitis. ebastine 0-8 interferon gamma Homo sapiens 19-28 18841321-7 2009 Preoperative IFN-gamma concentration was significantly higher in women with subsequent polypropylene mesh erosion when compared to women with successful outcome (p < 0.05). Polypropylenes 87-100 interferon gamma Homo sapiens 13-22 19606255-6 2009 A significant increase of IL-6, IL-12, IFN-gamma and TNF-alpha was observed in the HI group after treatment with FR-91. hi 83-85 interferon gamma Homo sapiens 39-48 19606255-6 2009 A significant increase of IL-6, IL-12, IFN-gamma and TNF-alpha was observed in the HI group after treatment with FR-91. fr-91 113-118 interferon gamma Homo sapiens 39-48 19321044-4 2009 The aim of this study is to preliminarily evaluate IFN-gamma production by peripheral blood mononuclear cells (PBMNC) and clinical changes after a treatment with lyophilized ebastine in patients with persistent allergic rhinitis (PER). ebastine 174-182 interferon gamma Homo sapiens 51-60 19321044-7 2009 IFN-gamma production by peripheral blood mononuclear cells (PBMNC) was evaluated using different stimuli, in un-treated and ebastine-treated allergic patients by ELISPOT. ebastine 124-132 interferon gamma Homo sapiens 0-9 19321044-8 2009 Ebastine treatment induced significant increase of IFN-gamma production stimulated by grasses (p<0.0001) and Dermatophagoides farinae (p=0.0015). ebastine 0-8 interferon gamma Homo sapiens 51-60 19321044-10 2009 In conclusion, this preliminary study demonstrates the effectiveness of ebastine treatment in increasing IFN-gamma production. ebastine 72-80 interferon gamma Homo sapiens 105-114 19056665-9 2009 Plasma vitamin C was associated with interferon-gamma (IFNgamma) (P < 0.01) and zinc with IFNgamma and interleukin-2 (each P < 0.0001). Ascorbic Acid 7-16 interferon gamma Homo sapiens 37-53 19056665-9 2009 Plasma vitamin C was associated with interferon-gamma (IFNgamma) (P < 0.01) and zinc with IFNgamma and interleukin-2 (each P < 0.0001). Ascorbic Acid 7-16 interferon gamma Homo sapiens 55-63 19056665-9 2009 Plasma vitamin C was associated with interferon-gamma (IFNgamma) (P < 0.01) and zinc with IFNgamma and interleukin-2 (each P < 0.0001). Ascorbic Acid 7-16 interferon gamma Homo sapiens 93-101 19254209-11 2009 It was revealed that disturbances of diastolic function of the heart had inflammatory genesis (IFN-gamma correlated with parameter of diastolic function DT; elevation of Il-6 level was found in restrictive type of diastolic function). Thymidine 153-155 interferon gamma Homo sapiens 95-104 19714290-7 2009 RESULTS: IL-10 significantly inhibited IFN-gamma- or TNF-alpha-induced up-regulation of superoxide-producing activity in T84 cells by suppressing expression of Nox1 mRNA and protein. Superoxides 88-98 interferon gamma Homo sapiens 39-48 19784600-3 2009 The Taqman Array results show that (1) stimulation with the liver-X-receptor and retinoid-X-receptor ligands T0901317 and 9-cis retinoic acid induces several genes of lipid metabolism, (2) lipopolysaccharide (LPS) and interferon-g (Ifn-g) strongly repress lipid-related genes, and (3) coincubation with docosahexaenoic acid dampens the repressing effect of LPS. T0901317 109-117 interferon gamma Homo sapiens 218-230 19784600-3 2009 The Taqman Array results show that (1) stimulation with the liver-X-receptor and retinoid-X-receptor ligands T0901317 and 9-cis retinoic acid induces several genes of lipid metabolism, (2) lipopolysaccharide (LPS) and interferon-g (Ifn-g) strongly repress lipid-related genes, and (3) coincubation with docosahexaenoic acid dampens the repressing effect of LPS. T0901317 109-117 interferon gamma Homo sapiens 232-237 19784600-3 2009 The Taqman Array results show that (1) stimulation with the liver-X-receptor and retinoid-X-receptor ligands T0901317 and 9-cis retinoic acid induces several genes of lipid metabolism, (2) lipopolysaccharide (LPS) and interferon-g (Ifn-g) strongly repress lipid-related genes, and (3) coincubation with docosahexaenoic acid dampens the repressing effect of LPS. Tretinoin 128-141 interferon gamma Homo sapiens 218-230 19784600-3 2009 The Taqman Array results show that (1) stimulation with the liver-X-receptor and retinoid-X-receptor ligands T0901317 and 9-cis retinoic acid induces several genes of lipid metabolism, (2) lipopolysaccharide (LPS) and interferon-g (Ifn-g) strongly repress lipid-related genes, and (3) coincubation with docosahexaenoic acid dampens the repressing effect of LPS. Tretinoin 128-141 interferon gamma Homo sapiens 232-237 18368485-3 2009 We conjectured that retinoid could induce differentiation with down regulation of telomerase activity to increase sensitivity to IFN-gamma for apoptosis in glioblastoma cells. Retinoids 20-28 interferon gamma Homo sapiens 129-138 19521914-6 2009 Treatment of cells with the Dicerocaryum extract resulted in dose-related inhibition of PHA-activated lymphocyte proliferation and expression of CD25, as well as decreased production of Th1 (IFN-gamma, TNF-alpha) and Th2 (IL-10) cytokines. dicerocaryum 28-40 interferon gamma Homo sapiens 191-200 18368485-5 2009 Wright staining and ApopTag assay showed, respectively, morphological and biochemical features of apoptosis in glioblastoma cells following exposure to 200 units/ml IFN-gamma for 48 h. Induction of differentiation was associated with decreases in levels of nuclear factor kappa B (NFkappaB), inducible nitric oxide synthase (iNOS), and production of nitric oxide (NO) so as to increase sensitivity to IFN-gamma for apoptosis. Nitric Oxide 302-314 interferon gamma Homo sapiens 165-174 18368485-10 2009 Taken together, our results showed that retinoid induced astrocytic differentiation with down regulation of telomerase activity and enhanced sensitivity to IFN-gamma for increasing apoptosis in human glioblastoma cells. Retinoids 40-48 interferon gamma Homo sapiens 156-165 18368485-7 2009 Also, IFN-gamma activated caspase-8 and cleaved Bid to truncated Bid (tBid) for translocation to mitochondria. tBID 70-74 interferon gamma Homo sapiens 6-15 19212126-6 2009 Further analysis showed that plasma DHEA levels correlated positively with the in vitroproduction of IFN-gamma by mycobacterial-stimulated PBMCs, and the cortisol/DHEA ratio was inversely correlated with IFN-gamma production. Dehydroepiandrosterone 36-40 interferon gamma Homo sapiens 101-110 19212126-6 2009 Further analysis showed that plasma DHEA levels correlated positively with the in vitroproduction of IFN-gamma by mycobacterial-stimulated PBMCs, and the cortisol/DHEA ratio was inversely correlated with IFN-gamma production. Hydrocortisone 154-162 interferon gamma Homo sapiens 204-213 19212126-6 2009 Further analysis showed that plasma DHEA levels correlated positively with the in vitroproduction of IFN-gamma by mycobacterial-stimulated PBMCs, and the cortisol/DHEA ratio was inversely correlated with IFN-gamma production. Dehydroepiandrosterone 163-167 interferon gamma Homo sapiens 204-213 19274101-10 2009 IFNgamma AA(lo) on the other hand in combination with IL10 GG(lo) increased the risk of PAD (OR = 5.26; p = 0.005) and DTB (OR = 3.59; p = 0.045). dodecyltriphenylphosphonium 119-122 interferon gamma Homo sapiens 0-8 18620901-3 2009 Administration of the agonistic Fas-antibody CH-11 led to a significant reduction of viable cells in the colorimetric MTT-assay in 5 out of 13 (38%) cell lines tested and preincubation with Interferon-gamma (IFN-gamma) rendered 3 (23%) primarily resistant cell lines sensitive. ammonium ferrous sulfate 32-35 interferon gamma Homo sapiens 190-206 18620901-3 2009 Administration of the agonistic Fas-antibody CH-11 led to a significant reduction of viable cells in the colorimetric MTT-assay in 5 out of 13 (38%) cell lines tested and preincubation with Interferon-gamma (IFN-gamma) rendered 3 (23%) primarily resistant cell lines sensitive. ammonium ferrous sulfate 32-35 interferon gamma Homo sapiens 208-217 18620901-3 2009 Administration of the agonistic Fas-antibody CH-11 led to a significant reduction of viable cells in the colorimetric MTT-assay in 5 out of 13 (38%) cell lines tested and preincubation with Interferon-gamma (IFN-gamma) rendered 3 (23%) primarily resistant cell lines sensitive. 4-dimethylamino-3',4'-dimethoxychalcone 45-50 interferon gamma Homo sapiens 190-206 18620901-3 2009 Administration of the agonistic Fas-antibody CH-11 led to a significant reduction of viable cells in the colorimetric MTT-assay in 5 out of 13 (38%) cell lines tested and preincubation with Interferon-gamma (IFN-gamma) rendered 3 (23%) primarily resistant cell lines sensitive. 4-dimethylamino-3',4'-dimethoxychalcone 45-50 interferon gamma Homo sapiens 208-217 19352428-4 2009 Gag-specific IFN-gamma-producing CD4+ T cell responses were detected in 261/373 (70%) subjects, with the Gag responders having a significantly lower viral load and higher CD4 count than those with no detectable Gag response (p<0.0001 for both parameters). Glycosaminoglycans 0-3 interferon gamma Homo sapiens 13-22 19352428-4 2009 Gag-specific IFN-gamma-producing CD4+ T cell responses were detected in 261/373 (70%) subjects, with the Gag responders having a significantly lower viral load and higher CD4 count than those with no detectable Gag response (p<0.0001 for both parameters). Glycosaminoglycans 105-108 interferon gamma Homo sapiens 13-22 19352428-4 2009 Gag-specific IFN-gamma-producing CD4+ T cell responses were detected in 261/373 (70%) subjects, with the Gag responders having a significantly lower viral load and higher CD4 count than those with no detectable Gag response (p<0.0001 for both parameters). Glycosaminoglycans 105-108 interferon gamma Homo sapiens 13-22 19352428-8 2009 CONCLUSIONS/SIGNIFICANCE: These data indicate that in chronic untreated clade C HIV-1 infection, IFN-gamma-secreting Gag-specific CD4+ T cell responses are immunodominant, directed at multiple distinct epitopes, and associated with viral control. Glycosaminoglycans 117-120 interferon gamma Homo sapiens 97-106 19125189-9 2009 CONCLUSIONS/ SIGNIFICANCE: By following quantitative IFNgamma values in each enrolled child with LTBI or active TB and receiving treatment, we were able to detect an increase in the IFNgamma response at day 10 of treatment which might allow the confirmation of a diagnosis. Terbium 98-100 interferon gamma Homo sapiens 53-61 19125189-9 2009 CONCLUSIONS/ SIGNIFICANCE: By following quantitative IFNgamma values in each enrolled child with LTBI or active TB and receiving treatment, we were able to detect an increase in the IFNgamma response at day 10 of treatment which might allow the confirmation of a diagnosis. Terbium 98-100 interferon gamma Homo sapiens 182-190 21033411-3 2009 Neopterin is a marker of cytotoxic lymphocytes T activities, it is produced by monocytes/macrophages stimulated with IFNgamma. Neopterin 0-9 interferon gamma Homo sapiens 117-125 19340290-12 2009 A positive correlation between ESAT6-induced IFNgamma and CXCL9 was present in all TB patients, but IFNgamma and CCL2 was only correlated in LNTB. Terbium 83-85 interferon gamma Homo sapiens 45-53 18948302-0 2009 TCDD-mediated suppression of the in vitro anti-sheep erythrocyte IgM antibody forming cell response is reversed by interferon-gamma. Polychlorinated Dibenzodioxins 0-4 interferon gamma Homo sapiens 115-131 18948302-2 2009 Based on evidence demonstrating that primary hepatocytes pretreated with interferon-gamma (IFN-gamma) exhibited decreased induction of cytochrome P450 1A1 (CYP1A1) by TCDD, and that serum factors alter the sensitivity of the in vitro T-cell-dependent IgM antibody forming cell (AFC) response, it was hypothesized that IFN-gamma attenuates suppression of humoral immune responses by TCDD. Polychlorinated Dibenzodioxins 167-171 interferon gamma Homo sapiens 73-89 18948302-3 2009 In fact, concomitant addition of IFN-gamma (100 U/ml) produced a concentration-related attenuation of TCDD-mediated suppression of the anti-sheep erythrocyte (anti-sRBC) IgM AFC response. Polychlorinated Dibenzodioxins 102-106 interferon gamma Homo sapiens 33-42 18948302-4 2009 Time-of-addition studies performed by adding 100 U/ml IFN-gamma at 0, 1, 2, 4, 12, 24, 48, and 72 h post-TCDD showed that suppression of the AFC response was prevented only when IFN-gamma was added within 2 h of TCDD treatment. Polychlorinated Dibenzodioxins 212-216 interferon gamma Homo sapiens 178-187 18948302-2 2009 Based on evidence demonstrating that primary hepatocytes pretreated with interferon-gamma (IFN-gamma) exhibited decreased induction of cytochrome P450 1A1 (CYP1A1) by TCDD, and that serum factors alter the sensitivity of the in vitro T-cell-dependent IgM antibody forming cell (AFC) response, it was hypothesized that IFN-gamma attenuates suppression of humoral immune responses by TCDD. Polychlorinated Dibenzodioxins 167-171 interferon gamma Homo sapiens 91-100 18948302-5 2009 mRNA levels of the IgM components, immunoglobulin kappa light chain, immunoglobulin mu heavy chain, and immunoglobulin J-chain were significantly decreased by TCDD treatment, an effect that was completely reversed by IFN-gamma (100 U/ml) cotreatment. Polychlorinated Dibenzodioxins 159-163 interferon gamma Homo sapiens 217-226 18948302-2 2009 Based on evidence demonstrating that primary hepatocytes pretreated with interferon-gamma (IFN-gamma) exhibited decreased induction of cytochrome P450 1A1 (CYP1A1) by TCDD, and that serum factors alter the sensitivity of the in vitro T-cell-dependent IgM antibody forming cell (AFC) response, it was hypothesized that IFN-gamma attenuates suppression of humoral immune responses by TCDD. Polychlorinated Dibenzodioxins 382-386 interferon gamma Homo sapiens 73-89 18948302-6 2009 Further studies showed that IFN-alpha, IFN-beta, and IFN-gamma significantly attenuate TCDD-induced increases in CYP1A1 mRNA levels to varying degrees, but concentrations as high as 1000 U/ml of type I IFNs did not reverse the effect of TCDD on the anti-sRBC IgM AFC response. Polychlorinated Dibenzodioxins 87-91 interferon gamma Homo sapiens 53-62 18948302-6 2009 Further studies showed that IFN-alpha, IFN-beta, and IFN-gamma significantly attenuate TCDD-induced increases in CYP1A1 mRNA levels to varying degrees, but concentrations as high as 1000 U/ml of type I IFNs did not reverse the effect of TCDD on the anti-sRBC IgM AFC response. Polychlorinated Dibenzodioxins 237-241 interferon gamma Homo sapiens 53-62 18948302-2 2009 Based on evidence demonstrating that primary hepatocytes pretreated with interferon-gamma (IFN-gamma) exhibited decreased induction of cytochrome P450 1A1 (CYP1A1) by TCDD, and that serum factors alter the sensitivity of the in vitro T-cell-dependent IgM antibody forming cell (AFC) response, it was hypothesized that IFN-gamma attenuates suppression of humoral immune responses by TCDD. Polychlorinated Dibenzodioxins 382-386 interferon gamma Homo sapiens 91-100 18948302-6 2009 Further studies showed that IFN-alpha, IFN-beta, and IFN-gamma significantly attenuate TCDD-induced increases in CYP1A1 mRNA levels to varying degrees, but concentrations as high as 1000 U/ml of type I IFNs did not reverse the effect of TCDD on the anti-sRBC IgM AFC response. srbc 254-258 interferon gamma Homo sapiens 53-62 18948302-7 2009 In summary, IFN-gamma prevents TCDD-mediated suppression of the IgM AFC response in a concentration- and time-related manner by altering transcriptional effects associated with TCDD treatment. Polychlorinated Dibenzodioxins 31-35 interferon gamma Homo sapiens 12-21 19697859-2 2009 Irrespective of the susceptibility of the causative agent to the essential antituberculous drugs, rifampicin was ascertained to initiate increased IL-2 secretion and to reduce the generation of IL-12, IFN-gamma and TGF-beta. Rifampin 98-108 interferon gamma Homo sapiens 201-210 18948302-7 2009 In summary, IFN-gamma prevents TCDD-mediated suppression of the IgM AFC response in a concentration- and time-related manner by altering transcriptional effects associated with TCDD treatment. Polychlorinated Dibenzodioxins 177-181 interferon gamma Homo sapiens 12-21 19697859-3 2009 Isoniazid suppressed the mononuclear leukocytic production of IFN-gamma in drug-sensitive pulmonary tuberculosis, and conversely, stimulated it in the drug-resistant type. Isoniazid 0-9 interferon gamma Homo sapiens 62-71 18976633-4 2008 Our results revealed that reactive oxygen species (ROS) induced endogenous pkr gene expression at the transcriptional level by activating the interferon (IFN)-gamma gene. Reactive Oxygen Species 26-49 interferon gamma Homo sapiens 142-164 18976633-4 2008 Our results revealed that reactive oxygen species (ROS) induced endogenous pkr gene expression at the transcriptional level by activating the interferon (IFN)-gamma gene. Reactive Oxygen Species 51-54 interferon gamma Homo sapiens 142-164 18976633-5 2008 However, IFN-gamma siRNA expression abrogated the H(2)O(2)-mediated pkr induction. o(2) 54-58 interferon gamma Homo sapiens 9-18 18976633-6 2008 The radical scavenger N-acetyl-l-cysteine profoundly inhibited pkr induction via the reduction of IFN-gamma expression. Acetylcysteine 22-41 interferon gamma Homo sapiens 98-107 18976633-8 2008 Finally, siRNA-mediated depletion of IFN-gamma or pkr efficiently downregulated H(2)O(2)-mediated apoptotic cell death. Hydrogen Peroxide 80-88 interferon gamma Homo sapiens 37-46 18983246-8 2008 Praziquantel treatment during pregnancy caused significant boosts in interferon-gamma (IFN-gamma), interleukin (IL)-2, IL-4, IL-5, IL-13, and IL-10 responses to schistosome worm antigen and in IFN-gamma, IL-5, and IL-13 responses to schistosome egg antigen, but these boosts were not as substantial as those seen for women treated after delivery. Praziquantel 0-12 interferon gamma Homo sapiens 69-85 18954258-5 2008 All 3 drugs had an inhibitory effect on IFN-gamma-induced phagosome maturation in phorbolmyristate acetate-differentiated human THP-1 cells. Tetradecanoylphorbol Acetate 82-106 interferon gamma Homo sapiens 40-49 18983246-8 2008 Praziquantel treatment during pregnancy caused significant boosts in interferon-gamma (IFN-gamma), interleukin (IL)-2, IL-4, IL-5, IL-13, and IL-10 responses to schistosome worm antigen and in IFN-gamma, IL-5, and IL-13 responses to schistosome egg antigen, but these boosts were not as substantial as those seen for women treated after delivery. Praziquantel 0-12 interferon gamma Homo sapiens 87-96 18983246-8 2008 Praziquantel treatment during pregnancy caused significant boosts in interferon-gamma (IFN-gamma), interleukin (IL)-2, IL-4, IL-5, IL-13, and IL-10 responses to schistosome worm antigen and in IFN-gamma, IL-5, and IL-13 responses to schistosome egg antigen, but these boosts were not as substantial as those seen for women treated after delivery. Praziquantel 0-12 interferon gamma Homo sapiens 193-202 19088044-7 2008 MDSC-mediated immune suppression and IFN-gamma down-regulation was reversible in vitro by exposing cells to the reactive oxygen species inhibitors. Reactive Oxygen Species 112-135 interferon gamma Homo sapiens 37-46 19050284-0 2008 The 15-deoxy-delta 12,14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1. 15-deoxy-delta(12,14)-prostaglandin J2 4-41 interferon gamma Homo sapiens 102-111 19050284-6 2008 The inhibitory effects of 15d-PGJ(2) on MCP-1 resulted from its actions on the transcription factors, AP-1 and specificity protein-1, which play key roles in IFN-gamma-induced MCP-1 expression in astrocytes. 15d-pgj 26-33 interferon gamma Homo sapiens 158-167 19035488-8 2008 MTX also prevented NS398 and IFNgamma from increasing transformation of lipid-laden THP-1 macrophages into foam cells. Methotrexate 0-3 interferon gamma Homo sapiens 29-37 19050300-6 2008 Patients with or without Lofgren syndrome had similar frequencies of mKatG specific IFN-gamma-expressing blood T cells. mkatg 69-74 interferon gamma Homo sapiens 84-93 18706662-6 2008 A striking functional finding was that while NKT-cells in unfractionated peripheral blood from healthy subjects expanded in number and produced IFN-gamma upon stimulation with alpha-galactosylceramide, NKT-cells from MS patients did not. alpha-galactosylceramide 176-200 interferon gamma Homo sapiens 144-153 19077897-10 2008 Serum levels of IL-18 and IFN-gamma were significantly elevated in the AR group with compared with the no AR group. Argon 71-73 interferon gamma Homo sapiens 26-35 19133006-6 2008 This study assessed the effect of interferon gamma and ligation of CD40 on the intracellular survival of NTHi in human monocytes. nthi 105-109 interferon gamma Homo sapiens 34-50 18849196-2 2008 In a previous report, we demonstrated that recombinant BCG (rBCG) expressing the full-length gag gene of simian immunodeficiency virus (SIV) (rBCG-SIVgag) induced Gag-specific delayed-type hypersensitivity, T cell proliferation, gamma interferon (IFN gamma), and serum IgG responses in guinea pigs immunized intradermally (i.d.) Glycosaminoglycans 93-96 interferon gamma Homo sapiens 247-256 18849196-2 2008 In a previous report, we demonstrated that recombinant BCG (rBCG) expressing the full-length gag gene of simian immunodeficiency virus (SIV) (rBCG-SIVgag) induced Gag-specific delayed-type hypersensitivity, T cell proliferation, gamma interferon (IFN gamma), and serum IgG responses in guinea pigs immunized intradermally (i.d.) Glycosaminoglycans 163-166 interferon gamma Homo sapiens 247-256 18849196-6 2008 To learn this, we examined Gag-specific IgG production in sera and Gag-specific IFN gamma mRNA expression in peripheral blood mononuclear cells (PBMC) in guinea pigs vaccinated with rBCG-SIVgag i.d. Glycosaminoglycans 67-70 interferon gamma Homo sapiens 80-89 18849196-10 2008 The enhancement of IFN gamma mRNA expression by in vitro restimulation with Gag antigen was also detected in PBMC from the two immunization groups throughout the 3-year observation period. Glycosaminoglycans 76-79 interferon gamma Homo sapiens 19-28 18686224-9 2008 However, simvastatin and atorvastatin could significantly inhibit the "aberrant" HLA-DR expression on HT thyrocytes and decrease IFN-gamma- induced HLA-DR expression in both HT and normal thyroid cells (p<0.01). Simvastatin 9-20 interferon gamma Homo sapiens 129-138 18849196-14 2008 and oral inoculations of rBCG-SIVgag elicit stable, strong, Gag-specific serum IgG production while exhibiting the different kinetics of Gag-specific IFN gamma responses between i.d. Glycosaminoglycans 137-140 interferon gamma Homo sapiens 150-159 18686224-9 2008 However, simvastatin and atorvastatin could significantly inhibit the "aberrant" HLA-DR expression on HT thyrocytes and decrease IFN-gamma- induced HLA-DR expression in both HT and normal thyroid cells (p<0.01). Atorvastatin 25-37 interferon gamma Homo sapiens 129-138 19119254-5 2008 RESULTS: In PBMCs from subjects exhibiting methacholine airway hyperresponsiveness (AHR), DHEA significantly suppressed IL-10, IL-5, and IFN-gamma production in a dose-dependent manner (all p<0.001) and tended to increase the IFN-gamma/IL-5 ratio (p=0.087). Dehydroepiandrosterone 90-94 interferon gamma Homo sapiens 137-146 19119254-5 2008 RESULTS: In PBMCs from subjects exhibiting methacholine airway hyperresponsiveness (AHR), DHEA significantly suppressed IL-10, IL-5, and IFN-gamma production in a dose-dependent manner (all p<0.001) and tended to increase the IFN-gamma/IL-5 ratio (p=0.087). Dehydroepiandrosterone 90-94 interferon gamma Homo sapiens 229-238 19119254-6 2008 DHEA (10 microM) suppressed cytokine production to a greater degree in subjects with AHR compared with those without AHR (IL-5: 24.0+/-7.8% vs. 40.9+/-3.6%, p<0.01; IFN-gamma: 29.7+/-7.0% vs. 54.5+/-5.1%, p<0.01). Dehydroepiandrosterone 0-4 interferon gamma Homo sapiens 168-177 18823288-0 2008 Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity. Tryptophan 0-10 interferon gamma Homo sapiens 80-96 18596134-6 2008 Combined results from EMSA and western blot analysis revealed the inhibitory ability of 15d-PGJ(2), but not of synthetic PPARgamma ligands, on IFN-gamma-induced tyrosine phosphorylation of JAK1, JAK2, STAT1 and nuclear STAT1 translocation and DNA binding. 15d-pgj 88-95 interferon gamma Homo sapiens 143-152 18596134-6 2008 Combined results from EMSA and western blot analysis revealed the inhibitory ability of 15d-PGJ(2), but not of synthetic PPARgamma ligands, on IFN-gamma-induced tyrosine phosphorylation of JAK1, JAK2, STAT1 and nuclear STAT1 translocation and DNA binding. Tyrosine 161-169 interferon gamma Homo sapiens 143-152 18823288-3 2008 The primary aim of this study was to test the hypothesis that IBS is associated with increased tryptophan (Trp) catabolism along the Kyn pathway due to increased IFN-gamma levels. Tryptophan 107-110 interferon gamma Homo sapiens 162-171 18823288-2 2008 Tryptophan forms the substrate for serotonin biosynthesis, but it can alternatively be catabolized to kynurenine (Kyn) by the enzyme indoleamine 2,3-dioxygenase (IDO), the main inducer of which is interferon-gamma. Tryptophan 0-10 interferon gamma Homo sapiens 197-213 18823288-10 2008 No difference in IFN-gamma levels was observed between groups; however, IFN-gamma was positively correlated with Kyn:Trp in IBS (r = 0.58, P = 0.005) but not controls (r = 0.12, P = 0.5). Kynurenine 113-116 interferon gamma Homo sapiens 72-81 18823288-10 2008 No difference in IFN-gamma levels was observed between groups; however, IFN-gamma was positively correlated with Kyn:Trp in IBS (r = 0.58, P = 0.005) but not controls (r = 0.12, P = 0.5). Tryptophan 117-120 interferon gamma Homo sapiens 72-81 18823288-2 2008 Tryptophan forms the substrate for serotonin biosynthesis, but it can alternatively be catabolized to kynurenine (Kyn) by the enzyme indoleamine 2,3-dioxygenase (IDO), the main inducer of which is interferon-gamma. Kynurenine 102-112 interferon gamma Homo sapiens 197-213 18823288-2 2008 Tryptophan forms the substrate for serotonin biosynthesis, but it can alternatively be catabolized to kynurenine (Kyn) by the enzyme indoleamine 2,3-dioxygenase (IDO), the main inducer of which is interferon-gamma. Kynurenine 114-117 interferon gamma Homo sapiens 197-213 18823288-3 2008 The primary aim of this study was to test the hypothesis that IBS is associated with increased tryptophan (Trp) catabolism along the Kyn pathway due to increased IFN-gamma levels. Tryptophan 95-105 interferon gamma Homo sapiens 162-171 19166216-1 2008 IFN-gamma and TNF-alpha were co-coupled to the polystyrene cell culture plate by the photo-immobilization method. Polystyrenes 47-58 interferon gamma Homo sapiens 0-9 19010851-8 2008 When cultured with autologous peripheral blood lymphocytes, dendritic cells loaded with reo-Mel induced lymphocyte expansion, IFN-gamma production, specific anti-Mel888 cell cytotoxicity, and cross-primed CD8+ T cells specific against the human tumor-associated antigen MART-1. reo-mel 88-95 interferon gamma Homo sapiens 126-135 18779390-6 2008 IL-12 and IL-18 stimulated autoreactively activated NKT cells to secrete IFN-gamma, and this was mediated by Janus kinase-signal transducers and activators of transcription (JAK-STAT)-dependent signaling without induction of calcium flux. Calcium 225-232 interferon gamma Homo sapiens 73-82 18981100-4 2008 Late donor T cell transfer to MC was associated with marked accumulation of anti-host CD8 cells within the spleen, but delayed kinetics of differentiation, reduced expression of effector molecules including IFN-gamma, impaired cytotoxicity, and higher rates of sustained apoptosis. Methylcholanthrene 30-32 interferon gamma Homo sapiens 207-216 18981763-5 2008 Surprisingly, numbers of phosphoantigen hydroxy-3-methyl-but-2-enyl pyrophosphate-specific IFNgamma+ Vgamma2Vdelta2+ T cells in the HIV + LTB group were much greater than those in the HIV + TB group (P < 0.001). hydroxy-3-methyl-but-2-enyl pyrophosphate 40-81 interferon gamma Homo sapiens 91-99 18981763-5 2008 Surprisingly, numbers of phosphoantigen hydroxy-3-methyl-but-2-enyl pyrophosphate-specific IFNgamma+ Vgamma2Vdelta2+ T cells in the HIV + LTB group were much greater than those in the HIV + TB group (P < 0.001). Terbium 139-141 interferon gamma Homo sapiens 91-99 18981763-7 2008 Numbers of hydroxy-3-methyl-but-2-enyl pyrophosphate-specific IFNgamma+ Vgamma2Vdelta2+ T cells were even five times greater than those of PPD-specific IFNgamma+ CD8 T cells within the HIV + LTB group. hydroxy-3-methyl-but-2-enyl pyrophosphate 11-52 interferon gamma Homo sapiens 62-70 18981763-8 2008 CONCLUSION: Potent immune responses of hydroxy-3-methyl-but-2-enyl pyrophosphate-specific IFNgamma+ Vgamma2Vdelta2+ T cells and PPD-specific IFNgamma+ CD8+ T cells were detected in HIV + LTB persons but not HIV + TB patients. hydroxy-3-methyl-but-2-enyl pyrophosphate 39-80 interferon gamma Homo sapiens 90-98 18793787-8 2008 A single systemic immunization with rMVA was sufficient to induce high-avidity IFN-gamma secreting CD8+ T cells in systemic organs, whereas a single mucosal immunization with rMVA was not sufficient to elicit high-avidity CD8+ T cells in mucosa. rmva 36-40 interferon gamma Homo sapiens 79-88 18995835-2 2008 Here we show that IFN-gamma activates a kinase cascade in which death-associated protein kinase-1 (DAPK) activates zipper-interacting protein kinase (ZIPK), culminating in L13a phosphorylation on Ser(77), L13a release from the ribosome, and translational silencing of GAIT element-bearing target mRNAs. Serine 196-199 interferon gamma Homo sapiens 18-27 18990205-8 2008 RESULTS: Modulation of IL-12 profiles in Cd- or Hg-exposed human PBMC was dose-dependent and significantly related to IFN-gamma levels as well as to the Th1- or Th2-polarized responses. Cadmium 41-43 interferon gamma Homo sapiens 118-127 18629525-6 2008 In addition, RANTES expression detected in supernatant of HaCaT cells stimulated with TNF-alpha and IFN-gamma reduced 25, 18 and 12%, respectively, when cultured with 0.1, 1 and 5 micromol/L acitretin. Acitretin 191-200 interferon gamma Homo sapiens 100-109 18572307-0 2008 Triptolide inhibits interferon-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells. triptolide 0-10 interferon gamma Homo sapiens 20-36 18572307-4 2008 In the present study, we demonstrated that triptolide was able to inhibit interferon-gamma-induced PD-L1 surface expression in human breast cancer cells. triptolide 43-53 interferon gamma Homo sapiens 74-90 18757244-2 2008 Atorvastatin, a cholesterol-lowering drug, also possess immunomodulatory effects, being able to downregulate IFNgamma-induced MHC-II expression. Cholesterol 16-27 interferon gamma Homo sapiens 109-117 18698005-3 2008 In the presence of exogenous PGE(2), peripheral blood mononuclear cells produced higher interleukin-17 (IL-17), C-C chemokine ligand 20 (CCL20)/macrophage inflammatory protein 3alpha (MIP-3alpha), CXC chemokine ligand 8 (CXCL8)/IL-8, and lower interferon-gamma and IL-22 levels than in control cultures. Prostaglandins E 29-32 interferon gamma Homo sapiens 244-260 18757244-2 2008 Atorvastatin, a cholesterol-lowering drug, also possess immunomodulatory effects, being able to downregulate IFNgamma-induced MHC-II expression. Atorvastatin 0-12 interferon gamma Homo sapiens 109-117 18805021-2 2008 In this study, supernatants from LPS/ATP-stimulated human monocytes were analyzed for their ability to induce IFNgamma production by KG-1 cells. Adenosine Triphosphate 37-40 interferon gamma Homo sapiens 110-118 18847306-2 2008 IDO is an IFN-gamma-inducible, intracellular enzyme that catalyzes the initial and rate-limiting step in the degradation of tryptophan. Tryptophan 124-134 interferon gamma Homo sapiens 10-19 18674641-6 2008 Naive T cells co-cultured with Sandaracopimaric acid- or Sandaracopimaradiene-3beta-ol-primed DC turned into typical Th1 cells, which produced large quantities of IFN-gamma and released small amounts of IL-4 depending on IL-12 secretion. sandaracopimaric acid 31-52 interferon gamma Homo sapiens 163-172 18674641-6 2008 Naive T cells co-cultured with Sandaracopimaric acid- or Sandaracopimaradiene-3beta-ol-primed DC turned into typical Th1 cells, which produced large quantities of IFN-gamma and released small amounts of IL-4 depending on IL-12 secretion. sandaracopimaradiene-3beta-ol 57-86 interferon gamma Homo sapiens 163-172 18552380-0 2008 Lack of IFN-gamma synthesis in aqueous humor during corneal graft rejection correlates with suppressed nitric oxide production by macrophages. Nitric Oxide 103-115 interferon gamma Homo sapiens 8-17 18552380-6 2008 However, IFN-gamma was undetectable unless cells were first stimulated in vitro with PMA and ionomycin, which yielded IFN-gamma in 25% of cells. Tetradecanoylphorbol Acetate 85-88 interferon gamma Homo sapiens 9-18 18552380-6 2008 However, IFN-gamma was undetectable unless cells were first stimulated in vitro with PMA and ionomycin, which yielded IFN-gamma in 25% of cells. Tetradecanoylphorbol Acetate 85-88 interferon gamma Homo sapiens 118-127 18552380-6 2008 However, IFN-gamma was undetectable unless cells were first stimulated in vitro with PMA and ionomycin, which yielded IFN-gamma in 25% of cells. Ionomycin 93-102 interferon gamma Homo sapiens 9-18 18552380-6 2008 However, IFN-gamma was undetectable unless cells were first stimulated in vitro with PMA and ionomycin, which yielded IFN-gamma in 25% of cells. Ionomycin 93-102 interferon gamma Homo sapiens 118-127 18989635-5 2008 Similarly, a marked increase in IFN-gamma levels was induced by adding bortezomib to BMSCs of fibroblast origin. Bortezomib 71-81 interferon gamma Homo sapiens 32-41 18829986-5 2008 Treatment of the variant with 5-azacytidine (5-aza), which inhibits CpG methylation, restores inducibility of HLA-II by IFN-gamma both at transcriptional and phenotypic level and antigen presenting and processing function of the variant. Azacitidine 30-43 interferon gamma Homo sapiens 120-129 18829986-5 2008 Treatment of the variant with 5-azacytidine (5-aza), which inhibits CpG methylation, restores inducibility of HLA-II by IFN-gamma both at transcriptional and phenotypic level and antigen presenting and processing function of the variant. Azacitidine 30-35 interferon gamma Homo sapiens 120-129 18829986-7 2008 Furthermore, treatment with 5-aza produces a substantial demethylation of CIITA promoter IV and a significant increase of IFN-gamma-dependent HLA-II expression in another myelomonocytic cell line, U937. Azacitidine 28-33 interferon gamma Homo sapiens 122-131 18833003-6 2008 Detection of intracellular cytokine production (interleukin-2, interferon-gamma, and tumor necrosis factor-alpha) upon phorbol 12-myristate 13-acetate-ionomycin stimulation in CD8alphaalpha+ and CD8alphabeta+ T-cells revealed that CD8alphaalpha+ T-cells show a unique cytokine production pattern (tumor necrosis factor-alpha and interferon-gamma production) as compared with CD8alphabeta+ T-cells. phorbol 119-126 interferon gamma Homo sapiens 63-112 18833003-6 2008 Detection of intracellular cytokine production (interleukin-2, interferon-gamma, and tumor necrosis factor-alpha) upon phorbol 12-myristate 13-acetate-ionomycin stimulation in CD8alphaalpha+ and CD8alphabeta+ T-cells revealed that CD8alphaalpha+ T-cells show a unique cytokine production pattern (tumor necrosis factor-alpha and interferon-gamma production) as compared with CD8alphabeta+ T-cells. phorbol 119-126 interferon gamma Homo sapiens 63-79 18833003-6 2008 Detection of intracellular cytokine production (interleukin-2, interferon-gamma, and tumor necrosis factor-alpha) upon phorbol 12-myristate 13-acetate-ionomycin stimulation in CD8alphaalpha+ and CD8alphabeta+ T-cells revealed that CD8alphaalpha+ T-cells show a unique cytokine production pattern (tumor necrosis factor-alpha and interferon-gamma production) as compared with CD8alphabeta+ T-cells. -myristate 13-acetate 129-150 interferon gamma Homo sapiens 63-112 18833003-6 2008 Detection of intracellular cytokine production (interleukin-2, interferon-gamma, and tumor necrosis factor-alpha) upon phorbol 12-myristate 13-acetate-ionomycin stimulation in CD8alphaalpha+ and CD8alphabeta+ T-cells revealed that CD8alphaalpha+ T-cells show a unique cytokine production pattern (tumor necrosis factor-alpha and interferon-gamma production) as compared with CD8alphabeta+ T-cells. Ionomycin 151-160 interferon gamma Homo sapiens 63-112 18833003-6 2008 Detection of intracellular cytokine production (interleukin-2, interferon-gamma, and tumor necrosis factor-alpha) upon phorbol 12-myristate 13-acetate-ionomycin stimulation in CD8alphaalpha+ and CD8alphabeta+ T-cells revealed that CD8alphaalpha+ T-cells show a unique cytokine production pattern (tumor necrosis factor-alpha and interferon-gamma production) as compared with CD8alphabeta+ T-cells. Ionomycin 151-160 interferon gamma Homo sapiens 63-79 19094432-5 2008 The IFN-gamma/IL-10 ratio after concanavalin A stimulation in whole blood cells on post-operative day 1 and SOCS-3 gene expression on post-operative day 2 were significantly lower in the remifentanil group than in the fentanyl group. Remifentanil 187-199 interferon gamma Homo sapiens 4-13 18833003-6 2008 Detection of intracellular cytokine production (interleukin-2, interferon-gamma, and tumor necrosis factor-alpha) upon phorbol 12-myristate 13-acetate-ionomycin stimulation in CD8alphaalpha+ and CD8alphabeta+ T-cells revealed that CD8alphaalpha+ T-cells show a unique cytokine production pattern (tumor necrosis factor-alpha and interferon-gamma production) as compared with CD8alphabeta+ T-cells. cd8alphaalpha 176-189 interferon gamma Homo sapiens 63-112 18833003-6 2008 Detection of intracellular cytokine production (interleukin-2, interferon-gamma, and tumor necrosis factor-alpha) upon phorbol 12-myristate 13-acetate-ionomycin stimulation in CD8alphaalpha+ and CD8alphabeta+ T-cells revealed that CD8alphaalpha+ T-cells show a unique cytokine production pattern (tumor necrosis factor-alpha and interferon-gamma production) as compared with CD8alphabeta+ T-cells. cd8alphaalpha 176-189 interferon gamma Homo sapiens 63-79 18639311-3 2008 A significant increase in IFNgamma and CD40 levels seen after miltefosine therapy could enhance parasite clearance. miltefosine 62-73 interferon gamma Homo sapiens 26-34 18991804-8 2008 IFN-gamma stimulates superoxide release and is a prophylactic agent for CGD. Superoxides 21-31 interferon gamma Homo sapiens 0-9 18706396-6 2008 Furthermore, supplementation with curcumin in the A549 human airway epithelial cells decreased iNOS and NO production induced by IFN-gamma. Curcumin 34-42 interferon gamma Homo sapiens 129-138 18927310-4 2008 EXPERIMENTAL DESIGN: Type-1 (IFNgamma) and type-2 (interleukin-4) responses were assessed in T cells at baseline and day 28 of treatment with sunitinib (50 mg/d) by measuring intracellular cytokines after in vitro stimulation with anti-CD3/anti-CD28 antibodies. Sunitinib 142-151 interferon gamma Homo sapiens 29-37 18655171-0 2008 IFN-gamma synergizes with LPS to induce nitric oxide biosynthesis through glycogen synthase kinase-3-inhibited IL-10. Nitric Oxide 40-52 interferon gamma Homo sapiens 0-9 18620001-4 2008 We further revealed that NK1.1 positive NK cells and NKT cells are responsible cells for producing IFN-gamma after stimulation with S-PT84 in vitro. s-pt84 132-138 interferon gamma Homo sapiens 99-108 18620001-5 2008 S-PT84 induced IFN-gamma-producing cells through activation of IL-12 production by CD11c(+)DCs in Toll-like receptor (TLR) 2- and/or TLR4-dependent manner. pt84 2-6 interferon gamma Homo sapiens 15-24 18655171-12 2008 Inhibiting protein tyrosine kinase Pyk2, an upstream regulator of GSK-3beta, caused inhibition on IFN-gamma/LPS-induced GSK-3beta phosphorylation at tyrosine 216 and iNOS/NO biosynthesis. Tyrosine 19-27 interferon gamma Homo sapiens 98-107 18692909-5 2008 Rivastigmine decreased the reactivity of encephalitogenic T-cells and the production of pro-inflammatory cytokines (TNF-alpha, IFN-gamma and IL-17) without affecting IL-10 production. Rivastigmine 0-12 interferon gamma Homo sapiens 127-136 18832710-0 2008 Inhibition of IFN-gamma-induced STAT1 tyrosine phosphorylation by human CMV is mediated by SHP2. Tyrosine 38-46 interferon gamma Homo sapiens 14-23 18832710-2 2008 IFN-gamma-induced signaling relies on the integrity of the JAK/STAT pathway which is regulated by phosphorylation steps and leads to nuclear translocation of tyrosine-phosphorylated STAT1 (STAT1-P-Tyr), and its binding to IFN-gamma activation site sequences of IFN-gamma-inducible promoters. Tyrosine 158-166 interferon gamma Homo sapiens 0-9 18832710-2 2008 IFN-gamma-induced signaling relies on the integrity of the JAK/STAT pathway which is regulated by phosphorylation steps and leads to nuclear translocation of tyrosine-phosphorylated STAT1 (STAT1-P-Tyr), and its binding to IFN-gamma activation site sequences of IFN-gamma-inducible promoters. Tyrosine 158-166 interferon gamma Homo sapiens 222-231 18832710-2 2008 IFN-gamma-induced signaling relies on the integrity of the JAK/STAT pathway which is regulated by phosphorylation steps and leads to nuclear translocation of tyrosine-phosphorylated STAT1 (STAT1-P-Tyr), and its binding to IFN-gamma activation site sequences of IFN-gamma-inducible promoters. Tyrosine 158-166 interferon gamma Homo sapiens 222-231 18832710-4 2008 Src homology region 2 domain-containing phosphatase 2 (SHP2) is a ubiquitous phosphatase involved in the regulation of IFN-gamma-mediated tyrosine phosphorylation. Tyrosine 138-146 interferon gamma Homo sapiens 119-128 18832710-12 2008 Our data suggest that SHP2 activation induced by HCMV infection is responsible for the down-regulation of IFN-gamma-induced STAT1 tyrosine phosphorylation. Tyrosine 130-138 interferon gamma Homo sapiens 106-115 18675871-3 2008 ELISPOT assay revealed that single or multiple protein immunization using both CpG ODN and Montanide ISA 720 as adjuvants induced much stronger IFN-gamma-producing Th1 responses against core, NS3 and NS5b targets than did the formulation without these adjuvants. montanide 91-100 interferon gamma Homo sapiens 144-153 21886711-4 2008 In this case of a patient who needs life-long therapy, we demonstrated the value of the IFN-gamma release test, which showed positive reactivity to 3 out of 9 suspicious drugs: paracetamol, phenytoin and dypirone, allowing for more therapeutic options. Acetaminophen 177-188 interferon gamma Homo sapiens 88-97 21886711-4 2008 In this case of a patient who needs life-long therapy, we demonstrated the value of the IFN-gamma release test, which showed positive reactivity to 3 out of 9 suspicious drugs: paracetamol, phenytoin and dypirone, allowing for more therapeutic options. Phenytoin 190-199 interferon gamma Homo sapiens 88-97 18692540-7 2008 We were also able to detect PPD-specific IFN-gamma release during short term culture of blood from a number of humans with active TB indicating that this test may have wider application and is potentially useful for the rapid diagnosis of disease in humans. Terbium 130-132 interferon gamma Homo sapiens 41-50 18515258-14 2008 Immune studies showed imatinib inhibits interferon-gamma production by TCR-activated CD4(+) T cells. Imatinib Mesylate 22-30 interferon gamma Homo sapiens 40-56 21886711-4 2008 In this case of a patient who needs life-long therapy, we demonstrated the value of the IFN-gamma release test, which showed positive reactivity to 3 out of 9 suspicious drugs: paracetamol, phenytoin and dypirone, allowing for more therapeutic options. dypirone 204-212 interferon gamma Homo sapiens 88-97 18548239-0 2008 Relationships between specific serum IgE, IgG, IFN-gamma level and IFN-gamma, IFNR1 polymorphisms in patients with penicillin allergy. Penicillins 115-125 interferon gamma Homo sapiens 47-56 18548239-0 2008 Relationships between specific serum IgE, IgG, IFN-gamma level and IFN-gamma, IFNR1 polymorphisms in patients with penicillin allergy. Penicillins 115-125 interferon gamma Homo sapiens 67-76 18548239-2 2008 We studied the polymorphisms in the interferon (IFN)-gamma (gamma) and IFN-gamma receptor 1 (IFNR1) gene with the aim of clarifying the relationships among these polymorphisms, penicillin allergy and anti-penicillin antibodies. Penicillins 177-187 interferon gamma Homo sapiens 36-58 18548239-2 2008 We studied the polymorphisms in the interferon (IFN)-gamma (gamma) and IFN-gamma receptor 1 (IFNR1) gene with the aim of clarifying the relationships among these polymorphisms, penicillin allergy and anti-penicillin antibodies. Penicillins 205-215 interferon gamma Homo sapiens 36-58 18619726-5 2008 RESULTS: Dasatinib inhibited proliferation of CD8+T cells in a dose-dependent manner, which was associated with lower secretion of interferon-gamma and granzyme B, as well as with arrest of CD8+T cells in the G0/G1 phase of cell cycle. Dasatinib 9-18 interferon gamma Homo sapiens 131-162 18827968-6 2008 RESULTS: In HT-29 cells, bindarit concentration-dependently and selectively inhibited MCP-1 secretion (as well as mRNA expression) primed by TNF-alpha/IFN-gamma. bindarit 25-33 interferon gamma Homo sapiens 151-160 18521569-12 2008 CONCLUSIONS: ATP and ADP at high-micromolar concentrations reduce secretion of the main Th1 cytokines TNFalpha, IL-12(p70) and IFNgamma in LPS stimulated human blood. Adenosine Triphosphate 13-16 interferon gamma Homo sapiens 127-135 18521569-0 2008 "Host tissue damage" signal ATP impairs IL-12 and IFNgamma secretion in LPS stimulated whole human blood. Adenosine Triphosphate 28-31 interferon gamma Homo sapiens 50-58 18521569-9 2008 ADP, ATPgammaS, BzATP, and CV1808, but not UTP displayed IL-12(p70) and IFNgamma reducing effect similar to ATP. Adenosine Diphosphate 0-3 interferon gamma Homo sapiens 72-80 18521569-12 2008 CONCLUSIONS: ATP and ADP at high-micromolar concentrations reduce secretion of the main Th1 cytokines TNFalpha, IL-12(p70) and IFNgamma in LPS stimulated human blood. Adenosine Diphosphate 21-24 interferon gamma Homo sapiens 127-135 18521569-9 2008 ADP, ATPgammaS, BzATP, and CV1808, but not UTP displayed IL-12(p70) and IFNgamma reducing effect similar to ATP. adenosine 5'-O-(3-thiotriphosphate) 5-14 interferon gamma Homo sapiens 72-80 18637077-8 2008 The duration of exposure of Mo-DC to the lipopeptides had little effect on phenotype, although Mo-DC exposed to lipopeptides for 48 rather than 4 h showed an increased ability to stimulate autologous peripheral blood mononuclear cells to release interferon-gamma in the absence of exogenous maturation factors. mo-dc 95-100 interferon gamma Homo sapiens 246-262 18521569-9 2008 ADP, ATPgammaS, BzATP, and CV1808, but not UTP displayed IL-12(p70) and IFNgamma reducing effect similar to ATP. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 16-21 interferon gamma Homo sapiens 72-80 18521569-9 2008 ADP, ATPgammaS, BzATP, and CV1808, but not UTP displayed IL-12(p70) and IFNgamma reducing effect similar to ATP. 2-phenylaminoadenosine 27-33 interferon gamma Homo sapiens 72-80 18521569-9 2008 ADP, ATPgammaS, BzATP, and CV1808, but not UTP displayed IL-12(p70) and IFNgamma reducing effect similar to ATP. Adenosine Triphosphate 5-8 interferon gamma Homo sapiens 72-80 18552712-7 2008 At 6 wks of age, infants fed Formula+LCP produced more TNF-alpha with SOY (3.2-fold) and IFN-gamma (3.3-fold) with BLG compared with infants fed Formula (p < 0.05). Perchloric Acid 37-40 interferon gamma Homo sapiens 89-98 18981654-2 2008 CsA is known to suppress the expression of inflammatory cytokines, including IL-2, IL-4, IFN-gamma and TNF-alpha in humans, dogs and experimental mice. Cyclosporine 0-3 interferon gamma Homo sapiens 89-98 18828896-9 2008 beta-estradiol levels were significantly higher in women having fertility disorders as compared to fertile women and have significant correlations (r = 0.65; P < 0.05) with pDCs numbers, CD80 expression, IL-6 levels and IFN-gamma levels in these women. Estradiol 0-14 interferon gamma Homo sapiens 223-232 19123327-0 2008 [Regulatory effect of procyanidins on the expressions of interferon-gamma, interleukin-12 and transcription factor T-bet mRNA in peripheral blood mononuclear cell of patients with alopecia areata]. Proanthocyanidins 22-34 interferon gamma Homo sapiens 57-73 19123327-1 2008 OBJECTIVE: To investigate the regulatory effect of procyanidins (PC) on the expressions of Th1 type cytokines (IFN-gamma and IL-12) and the transcription factor T-bet mRNA in peripheral blood mononuclear cell (PBMC) in patients with alopecia areata (AA). Proanthocyanidins 51-63 interferon gamma Homo sapiens 111-120 18712867-5 2008 The 4-fluorophenyloctanoyl-modified alpha-GalCer (18) was found to bind most strongly with CD1d (Ki 0.21 microM), 2 orders of magnitude stronger than alpha-GalCer and more than three times more selective than alpha-GalCer for IFN-gamma release from NKT cells. -fluorophenyloctanoyl 5-26 interferon gamma Homo sapiens 226-235 18712867-6 2008 Various alpha-GalCer analogues were analyzed, and the results showed that the binding affinity of glycolipids to CD1d correlates well with IFN-gamma production but poorly with IL-4 secretion by NKT cells, suggesting that tighter binding ligands could bias cytokine release through the T(H)1 pathway. Glycolipids 98-109 interferon gamma Homo sapiens 139-148 18768897-5 2008 Following beryllium exposure, CD4(+) T cells from blood and bronchoalveolar lavage of chronic beryllium disease patients up-regulate 4-1BB expression, and the majority of beryllium-responsive, IFN-gamma-producing CD4(+) T cells in blood coexpress CD28 and 4-1BB. Beryllium 10-19 interferon gamma Homo sapiens 193-202 18572022-6 2008 Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate. Nitrates 54-61 interferon gamma Homo sapiens 13-22 18572022-6 2008 Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate. Nitrates 182-189 interferon gamma Homo sapiens 13-22 18577441-4 2008 The action mechanisms of seselin may involve the regulation of cell cycle progression, interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production in PBMC. seselin 25-32 interferon gamma Homo sapiens 112-128 18791454-0 2008 Amelioration of human allograft arterial injury by atorvastatin or simvastatin correlates with reduction of interferon-gamma production by infiltrating T cells. Atorvastatin 51-63 interferon gamma Homo sapiens 108-124 18791454-0 2008 Amelioration of human allograft arterial injury by atorvastatin or simvastatin correlates with reduction of interferon-gamma production by infiltrating T cells. Simvastatin 67-78 interferon gamma Homo sapiens 108-124 18791454-9 2008 Graft arteriosclerosis directly induced by human IFN-gamma in the absence of human PBMCs was also reduced by atorvastatin, but only at the highest dose of 100 mg/kg/day. Atorvastatin 109-121 interferon gamma Homo sapiens 49-58 18577441-4 2008 The action mechanisms of seselin may involve the regulation of cell cycle progression, interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production in PBMC. seselin 25-32 interferon gamma Homo sapiens 130-139 18577441-7 2008 Furthermore, seselin significantly decreased the IL-2 and IFN-gamma gene expression in PHA-activated PBMC. seselin 13-20 interferon gamma Homo sapiens 58-67 18552877-6 2008 ASM cells were treated with tumour necrosis factor alpha (TNFalpha) and/or interferon gamma (IFNgamma) for 24 h in the presence of calcitriol and/or the glucocorticoid fluticasone added 2 h before. Calcitriol 131-141 interferon gamma Homo sapiens 93-101 18820767-8 2008 Significant IFN-gamma production was observed after Bt-ConA stimulation of Bt+ patients (P < 0.05), while Bt-total extract had no effect. bt-cona 52-59 interferon gamma Homo sapiens 12-21 18552877-10 2008 In TNFalpha/IFNgamma-treated cells, whereas fluticasone or calcitriol alone partially inhibited RANTES secretion (by 38 and 20%, respectively), the combination of both drugs additively inhibited RANTES secretion (by 60%). Fluticasone 44-55 interferon gamma Homo sapiens 12-20 18552877-10 2008 In TNFalpha/IFNgamma-treated cells, whereas fluticasone or calcitriol alone partially inhibited RANTES secretion (by 38 and 20%, respectively), the combination of both drugs additively inhibited RANTES secretion (by 60%). Calcitriol 59-69 interferon gamma Homo sapiens 12-20 18853120-0 2008 Effect of ligustrazine injection on levels of interleukin-4 and interferon-gamma in patients with bronchial asthma. tetramethylpyrazine 10-22 interferon gamma Homo sapiens 64-80 18757424-6 2008 Furthermore, soluble TSP1 stimulates killing of breast carcinoma and melanoma cells by IFN-gamma-differentiated U937 cells in vitro via release of reactive oxygen species. Reactive Oxygen Species 147-170 interferon gamma Homo sapiens 87-96 18853120-1 2008 OBJECTIVE: To explore the effect of ligustrazine injection (LI) on serum levels of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in patients with bronchial asthma and determine the mechanism of action of LI in preventing and treating asthma. tetramethylpyrazine 36-48 interferon gamma Homo sapiens 108-124 18853120-1 2008 OBJECTIVE: To explore the effect of ligustrazine injection (LI) on serum levels of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in patients with bronchial asthma and determine the mechanism of action of LI in preventing and treating asthma. tetramethylpyrazine 36-48 interferon gamma Homo sapiens 126-135 18647323-7 2008 When DC and NK cells were treated with ifosfamide, DC could overcome the negative effect of ifosfamide on NK cytotoxic function whereas NK cell IFN-gamma production was less efficiently restored. Ifosfamide 39-49 interferon gamma Homo sapiens 144-153 18781914-4 2008 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is cofactor for several aromatic amino acid monooxygenases and thus is strongly involved in the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). sapropterin 78-105 interferon gamma Homo sapiens 30-46 18781914-4 2008 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is cofactor for several aromatic amino acid monooxygenases and thus is strongly involved in the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). sapropterin 107-110 interferon gamma Homo sapiens 30-46 18781914-4 2008 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is cofactor for several aromatic amino acid monooxygenases and thus is strongly involved in the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). Serotonin 252-261 interferon gamma Homo sapiens 30-46 18781914-4 2008 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is cofactor for several aromatic amino acid monooxygenases and thus is strongly involved in the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). Dopamine 285-293 interferon gamma Homo sapiens 30-46 18781914-4 2008 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is cofactor for several aromatic amino acid monooxygenases and thus is strongly involved in the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). Epinephrine 295-306 interferon gamma Homo sapiens 30-46 18781914-4 2008 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is cofactor for several aromatic amino acid monooxygenases and thus is strongly involved in the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). Epinephrine 308-318 interferon gamma Homo sapiens 30-46 18781914-4 2008 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is cofactor for several aromatic amino acid monooxygenases and thus is strongly involved in the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). Norepinephrine 324-338 interferon gamma Homo sapiens 30-46 18781914-4 2008 The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is cofactor for several aromatic amino acid monooxygenases and thus is strongly involved in the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline). Norepinephrine 340-353 interferon gamma Homo sapiens 30-46 18781914-5 2008 In macrophages, interferon-gamma also triggers the high output of reactive oxygen species, which can destroy the oxidation-labile BH4. Reactive Oxygen Species 66-89 interferon gamma Homo sapiens 16-32 18781914-5 2008 In macrophages, interferon-gamma also triggers the high output of reactive oxygen species, which can destroy the oxidation-labile BH4. sapropterin 130-133 interferon gamma Homo sapiens 16-32 18792400-2 2008 Glucose deprivation or inhibition of glycolysis by 2-deoxy-D-glucose (2-DG) selectively inhibited production of IFN-gamma but not of IL-2. Deoxyglucose 70-74 interferon gamma Homo sapiens 112-121 18384428-9 2008 However, IFN-gamma responses towards chromium chloride were significantly correlated with the strength of patch test reactivity (r=0.49, P=0.002). chromous chloride 37-54 interferon gamma Homo sapiens 9-18 18792400-2 2008 Glucose deprivation or inhibition of glycolysis by 2-deoxy-D-glucose (2-DG) selectively inhibited production of IFN-gamma but not of IL-2. Deoxyglucose 51-68 interferon gamma Homo sapiens 112-121 19102366-6 2008 The increase in interferon-gamma following ribavirin monotherapy was significantly higher for patients with sustained viral response. Ribavirin 43-52 interferon gamma Homo sapiens 16-32 18558402-7 2008 Additionally, the effect of PPG on reactive oxygen species (ROS) production and induction of IL-10, IL-12 and IFN-gamma secretion by human peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals was investigated. ppg 28-31 interferon gamma Homo sapiens 110-119 18558402-8 2008 The water-soluble secreted form of PPG at a concentration of 1 microg glycan/ml seems to be a potent inducer of ROS and IL-10 and to a lesser extent of IFN-gamma and IL-12. Water 4-9 interferon gamma Homo sapiens 152-161 18558402-8 2008 The water-soluble secreted form of PPG at a concentration of 1 microg glycan/ml seems to be a potent inducer of ROS and IL-10 and to a lesser extent of IFN-gamma and IL-12. ppg 35-38 interferon gamma Homo sapiens 152-161 18558402-8 2008 The water-soluble secreted form of PPG at a concentration of 1 microg glycan/ml seems to be a potent inducer of ROS and IL-10 and to a lesser extent of IFN-gamma and IL-12. Polysaccharides 70-76 interferon gamma Homo sapiens 152-161 18425803-11 2008 Stimulation of human T cells with ghrelin increased levels of IL-4 and IL-13 proteins and decreased levels of IFN-gamma protein. Ghrelin 34-41 interferon gamma Homo sapiens 110-119 18546289-8 2008 Bi20 induced a strong Th1 cytokine pattern characterized by high IFN-gamma and very low IL-4 secretion. bi20 0-4 interferon gamma Homo sapiens 65-74 18815150-10 2008 Melatonin"s oncostatic actions include the direct augmentation of natural killer (NK) cell activity, which increases immunosurveillance, as well as the stimulation of cytokine production, for example, of interleukin (IL)-2, IL-6, IL-12, and interferon (IFN)-gamma. Melatonin 0-9 interferon gamma Homo sapiens 241-263 18728974-3 2008 The effects of cytotoxic drugs and IFNgamma combined with cytotoxic drugs on the growth and apoptosis of SH-SY5Y cells were detected with the methods of MTT and flow cytometry. monooxyethylene trimethylolpropane tristearate 153-156 interferon gamma Homo sapiens 35-43 18728974-7 2008 The authors conclude that IFNgamma can sensitize SH-SY5Y cells to Adriamycin-, TNFalpha-, and TRAIL-induced apoptosis and this may be realized by the upregulation of caspase 8. Doxorubicin 66-76 interferon gamma Homo sapiens 26-34 18511701-10 2008 CONCLUSIONS: One mechanism of IFN-gamma protection against IPS is negative regulation of the expansion of pathogenic IL-17A-producing CD4(+) T cells through interaction with the IFN-gamma receptor on the pulmonary parenchymal cell population. IPS 59-62 interferon gamma Homo sapiens 30-39 18676203-4 2008 Non-resistant TB patients present specific cellular responses (CD4 and CD8, both IFN-gamma and IL-10) to GlcB, MPT-51 and ESAT-6; while MDR-TB patients present only CD8+IFN-gamma+ responses to ESAT-6 and CD8+IL-10+ responses to GlcB and ESAT-6. glcb 105-109 interferon gamma Homo sapiens 81-90 18511701-10 2008 CONCLUSIONS: One mechanism of IFN-gamma protection against IPS is negative regulation of the expansion of pathogenic IL-17A-producing CD4(+) T cells through interaction with the IFN-gamma receptor on the pulmonary parenchymal cell population. IPS 59-62 interferon gamma Homo sapiens 178-187 18684924-6 2008 Furthermore, we show in a model of acute IPA intoxication that animals became immunosuppressed as judged by their reduced ability to release IL-2 and IFN-gamma in the serum in response to staphylococcal enterotoxin B. 2-Propanol 41-44 interferon gamma Homo sapiens 150-159 18562016-0 2008 Lipoic acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN gamma synthesis and cellular cytotoxicity in NK cells. Thioctic Acid 0-11 interferon gamma Homo sapiens 93-102 18620489-6 2008 When stimulated with heat-killed Mycobacterium avium complex (MAC) and phorbol myristic acetate (PMA), the mononuclear cells of patients with advanced HIV-1 infection had lowered ability to produce additional interferon-gamma (either MAC or PMA) and interferon-gamma receptors (MAC). phorbol myristic acetate 71-95 interferon gamma Homo sapiens 209-225 18620489-6 2008 When stimulated with heat-killed Mycobacterium avium complex (MAC) and phorbol myristic acetate (PMA), the mononuclear cells of patients with advanced HIV-1 infection had lowered ability to produce additional interferon-gamma (either MAC or PMA) and interferon-gamma receptors (MAC). phorbol myristic acetate 71-95 interferon gamma Homo sapiens 250-266 18620489-6 2008 When stimulated with heat-killed Mycobacterium avium complex (MAC) and phorbol myristic acetate (PMA), the mononuclear cells of patients with advanced HIV-1 infection had lowered ability to produce additional interferon-gamma (either MAC or PMA) and interferon-gamma receptors (MAC). Tetradecanoylphorbol Acetate 97-100 interferon gamma Homo sapiens 209-225 18620489-6 2008 When stimulated with heat-killed Mycobacterium avium complex (MAC) and phorbol myristic acetate (PMA), the mononuclear cells of patients with advanced HIV-1 infection had lowered ability to produce additional interferon-gamma (either MAC or PMA) and interferon-gamma receptors (MAC). Tetradecanoylphorbol Acetate 97-100 interferon gamma Homo sapiens 250-266 18502198-4 2008 In addition, CIM significantly promotes an elevated level of IL-4 and IFN-gamma in antigen-specific CD4(+) T cells and a robust antigen-specific cytotoxic response in the animals immunized with pcD-S2 plus CIM. Cimetidine 13-16 interferon gamma Homo sapiens 70-79 18666256-11 2008 Selective inhibition of p38MAPK activity by SB203580 abrogated the IFN-gamma response to adiponectin, whereas extracellular signal-regulated kinase 1/2 inhibition by PD98059 did not affect the response. SB 203580 44-52 interferon gamma Homo sapiens 67-76 18539902-4 2008 Increased levels of serum tumor necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma) were observed after allo-BMT and continuous bortezomib administration. Bortezomib 141-151 interferon gamma Homo sapiens 69-96 18539902-8 2008 Importantly, prolonged administration of bortezomib after transplantation of purified CD8(+) T cells resulted in enhanced GVT response, which was dependent on donor CD8(+) T cell-derived IFNgamma. Bortezomib 41-51 interferon gamma Homo sapiens 187-195 18372499-7 2008 Greater frequencies of CD56(bright) NK cells from chronic HCV patients produced interferon-gamma compared with HCV responders (p = 0.05) and controls (p = 0.0001) after phorbol ester stimulation in vitro. Phorbol Esters 169-182 interferon gamma Homo sapiens 80-96 18397271-9 2008 Combined treatment significantly increased the production level of IFN-gamma and TNF-alpha compared with that by AdmIL-12 or PDT alone. admil-12 113-121 interferon gamma Homo sapiens 67-76 18852529-0 2008 Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes. Glycine 0-7 interferon gamma Homo sapiens 68-84 18852529-10 2008 These data showed that patients treated with glycine had a significant decrease in A1C and in proinflammatory cytokines and also an important increase of IFN-gamma. Glycine 45-52 interferon gamma Homo sapiens 154-163 18641361-2 2008 In the present study we investigated the expression of IFN-gamma in peripheral blood T cells from patients with SLE and its role in the production of the soluble B lymphocyte stimulator (sBLyS). sblys 187-192 interferon gamma Homo sapiens 55-64 18641361-6 2008 T cell culture supernatants from patients with SLE contained significantly higher sBLyS-inducing activity than normal controls; this was almost completely inhibited by the addition of anti-human IFN-gamma mAb. sblys 82-87 interferon gamma Homo sapiens 195-204 18641343-3 2008 We studied the effects of cAMP response element binding protein/activating transcription factor (CREB/ATF) and AP-1 transcription factors on the proximal promoter of IFN-gamma in human T cells stimulated with Mycobacterium tuberculosis. Cyclic AMP 26-30 interferon gamma Homo sapiens 166-175 18641361-8 2008 Monocytes from patients with SLE produced significantly larger amounts of sBLyS in response to IFN-gamma than those from normal controls. sblys 74-79 interferon gamma Homo sapiens 95-104 18641361-9 2008 Taken together, these data strongly indicate that the overexpression of IFN-gamma in peripheral blood T cells contributes to the immunopathogenesis of SLE via the induction of sBLyS by monocytes/macrophages, which would promote B cell activation and maturation. sblys 176-181 interferon gamma Homo sapiens 72-81 18678988-3 2008 We investigated effects of interferon-gamma (INF-gamma) on ATP-induced responses in vascular endothelial cells. Adenosine Triphosphate 59-62 interferon gamma Homo sapiens 27-43 18678988-3 2008 We investigated effects of interferon-gamma (INF-gamma) on ATP-induced responses in vascular endothelial cells. Adenosine Triphosphate 59-62 interferon gamma Homo sapiens 45-54 18678988-4 2008 Treatment of human umbilical vein endothelial cells (HUVECs) with IFN-gamma for 24 h resulted in an enhancement of the ATP-induced increase in intracellular Ca2+ concentration ([Ca2+]i) without affecting the UTP-induced one. Adenosine Triphosphate 119-122 interferon gamma Homo sapiens 66-75 18678988-4 2008 Treatment of human umbilical vein endothelial cells (HUVECs) with IFN-gamma for 24 h resulted in an enhancement of the ATP-induced increase in intracellular Ca2+ concentration ([Ca2+]i) without affecting the UTP-induced one. Uridine Triphosphate 208-211 interferon gamma Homo sapiens 66-75 18678988-5 2008 The increased Ca2+ response to ATP in IFN-gamma-treated cells was dependent on the extracellular Ca2+, and was not inhibited by the phospholipase C inhibitor U73122. Adenosine Triphosphate 31-34 interferon gamma Homo sapiens 38-47 18678988-5 2008 The increased Ca2+ response to ATP in IFN-gamma-treated cells was dependent on the extracellular Ca2+, and was not inhibited by the phospholipase C inhibitor U73122. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 158-164 interferon gamma Homo sapiens 38-47 18678988-7 2008 IFN-gamma increased P2X4-receptor mRNA and protein, accompanied by an increase in ATP-triggered membrane current. Adenosine Triphosphate 82-85 interferon gamma Homo sapiens 0-9 18678988-8 2008 IFN-gamma did not affect P2X4-receptor mRNA stability, but increased P2X4-receptor gene transcription in a cycloheximide-insensitive manner. Cycloheximide 107-120 interferon gamma Homo sapiens 0-9 18678988-10 2008 Epigallocatechin gallate (EGCG), an inhibitor of STAT1-mediated signaling, and AG490, a Janus kinase (JAK) inhibitor, impaired P2X4-receptor mRNA up-regulation by IFN-gamma. epigallocatechin gallate 0-24 interferon gamma Homo sapiens 163-172 18678988-10 2008 Epigallocatechin gallate (EGCG), an inhibitor of STAT1-mediated signaling, and AG490, a Janus kinase (JAK) inhibitor, impaired P2X4-receptor mRNA up-regulation by IFN-gamma. epigallocatechin gallate 26-30 interferon gamma Homo sapiens 163-172 18678988-10 2008 Epigallocatechin gallate (EGCG), an inhibitor of STAT1-mediated signaling, and AG490, a Janus kinase (JAK) inhibitor, impaired P2X4-receptor mRNA up-regulation by IFN-gamma. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 79-84 interferon gamma Homo sapiens 163-172 18719314-2 2008 Cocaine self-administered for 18 days induced a significant increase in spleen weight, plasma corticosterone levels, interleukin (IL)-10, and tumor necrosis factor-alpha production, while concanavalin A-stimulated proliferation responses of peripheral blood T-lymphocytes and interferon-gamma production by splenic lymphocytes were not altered. Cocaine 0-7 interferon gamma Homo sapiens 276-292 18712654-6 2008 Supplementation with interferon-gamma could up-regulate this basal L-kynurenine production. Kynurenine 67-79 interferon gamma Homo sapiens 21-37 18766973-7 2008 Finally, pre-incubation of CTL with CD2 antibodies led to an Fc-dependent redistribution of CD2 into TC-induced synapses and restored IFN-gamma production by CMV-specific CTL. Technetium 101-103 interferon gamma Homo sapiens 134-143 19112904-0 2008 [Curcumin inhibiting the expression of indoleamine 2,3-dioxygenase induced by IFN-gamma in cancer cells]. Curcumin 1-9 interferon gamma Homo sapiens 78-87 18579365-2 2008 Neopterin (NP) is a monocyte/macrophage activation marker produced by macrophages in response to interferon-gamma secreted by activated T-lymphocytes. Neopterin 0-9 interferon gamma Homo sapiens 97-113 18579365-2 2008 Neopterin (NP) is a monocyte/macrophage activation marker produced by macrophages in response to interferon-gamma secreted by activated T-lymphocytes. Neopterin 11-13 interferon gamma Homo sapiens 97-113 19112904-1 2008 OBJECTIVE: To investigate the effect of curcumin on indoleamine 2, 3 -dioxygenase (IDO) expression induced by IFN-gamma in cancer cells. Curcumin 40-48 interferon gamma Homo sapiens 110-119 19112904-3 2008 The effects of curcumin on IDO expression induced by IFN-gamma in these cancer cells were demonstrated by Western blot. Curcumin 15-23 interferon gamma Homo sapiens 53-62 18406597-3 2008 IFN-gamma was detected by its 5"-thiol-modified aptamer probe immobilized on the gold electrode. 5"-thiol 30-38 interferon gamma Homo sapiens 0-9 18406597-5 2008 The RNA-aptamer-based sensor showed a low detection limit of 100 fM, and the DNA-aptamer-based sensor detected IFN-gamma to 1 pM in sodium phosphate buffer. sodium phosphate 132-148 interferon gamma Homo sapiens 111-120 18628480-5 2008 RESULTS: Lenalidomide directly enhanced IFN-gamma production via Fc-gamma receptor-mediated signaling in response to IgG. Lenalidomide 9-21 interferon gamma Homo sapiens 40-49 18423409-4 2008 DAHP reduced the levels of both BH(4) and VCAM-1 induced by TNF-alpha and IFN-gamma. 2,4-diaminohypoxanthine 0-4 interferon gamma Homo sapiens 74-83 18407307-7 2008 Arsenic exposure reduced the proliferative response of SMC to Con-A, and also reduced secretion of IL-2, IL-6, IL-12 and IFNgamma. Arsenic 0-7 interferon gamma Homo sapiens 121-129 18541274-0 2008 Attenuation of interferon-gamma mRNA expression in activated Jurkat T cells by exogenous zinc via down-regulation of the calcium-independent PKC-AP-1 signaling pathway. Calcium 121-128 interferon gamma Homo sapiens 15-31 18541274-3 2008 Zinc significantly reduced IFN-gamma expression and activator protein-1 (AP-1) signaling in cells activated by phorbol 12-myristate 13-acetate (PMA) and phytohemagglutinin (PHA) without affecting cell viability. Tetradecanoylphorbol Acetate 111-142 interferon gamma Homo sapiens 27-36 18541274-3 2008 Zinc significantly reduced IFN-gamma expression and activator protein-1 (AP-1) signaling in cells activated by phorbol 12-myristate 13-acetate (PMA) and phytohemagglutinin (PHA) without affecting cell viability. Tetradecanoylphorbol Acetate 144-147 interferon gamma Homo sapiens 27-36 18541274-4 2008 Moreover, partial inhibition of AP-1 activity by SP600125, a c-Jun N-terminal kinase (JNK) inhibitor, resulted in marked reduction of IFN-gamma transcription. pyrazolanthrone 49-57 interferon gamma Homo sapiens 134-143 18541274-6 2008 These results suggest a novel target of zinc in the calcium-independent protein kinase C-AP-1 pathway to regulate endogenous IFN-gamma gene expression in activated T cells. Calcium 52-59 interferon gamma Homo sapiens 125-134 18496872-7 2008 Those results all together indicate that UTP and UDP-Glc syntheses in CHO cells cultivated in SF-RPMI medium in batch process, could be limiting during the glycosylation processes of the recombinant IFN-gamma. Uridine Triphosphate 41-44 interferon gamma Homo sapiens 199-208 18496872-7 2008 Those results all together indicate that UTP and UDP-Glc syntheses in CHO cells cultivated in SF-RPMI medium in batch process, could be limiting during the glycosylation processes of the recombinant IFN-gamma. Uridine Diphosphate Glucose 49-56 interferon gamma Homo sapiens 199-208 18496872-7 2008 Those results all together indicate that UTP and UDP-Glc syntheses in CHO cells cultivated in SF-RPMI medium in batch process, could be limiting during the glycosylation processes of the recombinant IFN-gamma. sf-rpmi medium 94-108 interferon gamma Homo sapiens 199-208 18498417-6 2008 RESULTS: DC from control, non-atopic, donors produced cytokines differentially in response to sensitizer treatment; DNCB treatment significantly increased the production of Th1 cytokines IL-12 and IFN-gamma while TMA induced the production of IL-13. Dinitrochlorobenzene 116-120 interferon gamma Homo sapiens 197-206 18372324-9 2008 In human thyrocytes, elocalcitol inhibited IFNgamma and TNFalpha-induced CXCL10 protein secretion more potently than MMI. BXL628 21-32 interferon gamma Homo sapiens 43-51 18167173-9 2008 CLA supplementation decreased the in vitro production of TNF-alpha (P < 0.01), interferon-gamma (P < 0.05) and IL-5 (P < 0.05). Linoleic Acids, Conjugated 0-3 interferon gamma Homo sapiens 82-98 18506884-0 2008 Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: Implications for rheumatoid arthritis. Dinoprostone 41-59 interferon gamma Homo sapiens 64-73 18506884-5 2008 This effect of the PGE(2)/EP4 axis on IFN-gamma is a reciprocal phenomenon since IFN-gamma blocks PGE(2) release and blocks EP receptor expression. Prostaglandins E 19-22 interferon gamma Homo sapiens 38-47 18506884-5 2008 This effect of the PGE(2)/EP4 axis on IFN-gamma is a reciprocal phenomenon since IFN-gamma blocks PGE(2) release and blocks EP receptor expression. Prostaglandins E 19-22 interferon gamma Homo sapiens 81-90 18506884-5 2008 This effect of the PGE(2)/EP4 axis on IFN-gamma is a reciprocal phenomenon since IFN-gamma blocks PGE(2) release and blocks EP receptor expression. Prostaglandins E 98-101 interferon gamma Homo sapiens 38-47 18506884-5 2008 This effect of the PGE(2)/EP4 axis on IFN-gamma is a reciprocal phenomenon since IFN-gamma blocks PGE(2) release and blocks EP receptor expression. Prostaglandins E 98-101 interferon gamma Homo sapiens 81-90 18506884-6 2008 The mutually antagonistic relationship between IFN-gamma and PGE(2) extends to downstream cytokine and chemokine release; PGE(2) counters the effects of IFN-gamma, on the release of IP-10, IL-8, TNF-alpha and IL-1beta. Prostaglandins E 122-125 interferon gamma Homo sapiens 153-162 18506884-9 2008 These results suggest the existence of a mutually antagonistic relationship between PGE(2) and IFN-gamma, which may represent a fundamental mechanism of immune control in diseases such as RA. Prostaglandins E 84-87 interferon gamma Homo sapiens 95-104 18546145-5 2008 Here we discuss how activation of macrophages with IFN-gamma not only up-regulates antimicrobial effector mechanisms but also modulates iron regulatory proteins such as ferroportin to reduce intracellular iron availability. Iron 136-140 interferon gamma Homo sapiens 51-60 18546145-5 2008 Here we discuss how activation of macrophages with IFN-gamma not only up-regulates antimicrobial effector mechanisms but also modulates iron regulatory proteins such as ferroportin to reduce intracellular iron availability. Iron 205-209 interferon gamma Homo sapiens 51-60 18566411-7 2008 The repressive effect of IFN-gamma on the FcRn promoter was selectively reversed or blocked by mutations of the core nucleotides in the IFN-gamma activation site sequence and by overexpression of the STAT-1 inhibitor PIAS1 or the dominant negative phospho-STAT-1 mutations at Tyr-701 and/or Ser-727 residues. Tyrosine 276-279 interferon gamma Homo sapiens 25-34 18599961-8 2008 If a brain section was rinsed with phosphate buffered saline containing 0.1% Triton X-100, most LPS/IFN-gamma-activated THP-1 cells failed to adhere. Phosphate-Buffered Saline 35-60 interferon gamma Homo sapiens 100-109 18599961-8 2008 If a brain section was rinsed with phosphate buffered saline containing 0.1% Triton X-100, most LPS/IFN-gamma-activated THP-1 cells failed to adhere. Octoxynol 77-89 interferon gamma Homo sapiens 100-109 18566411-7 2008 The repressive effect of IFN-gamma on the FcRn promoter was selectively reversed or blocked by mutations of the core nucleotides in the IFN-gamma activation site sequence and by overexpression of the STAT-1 inhibitor PIAS1 or the dominant negative phospho-STAT-1 mutations at Tyr-701 and/or Ser-727 residues. Tyrosine 276-279 interferon gamma Homo sapiens 136-145 18566411-7 2008 The repressive effect of IFN-gamma on the FcRn promoter was selectively reversed or blocked by mutations of the core nucleotides in the IFN-gamma activation site sequence and by overexpression of the STAT-1 inhibitor PIAS1 or the dominant negative phospho-STAT-1 mutations at Tyr-701 and/or Ser-727 residues. Serine 291-294 interferon gamma Homo sapiens 25-34 18566411-7 2008 The repressive effect of IFN-gamma on the FcRn promoter was selectively reversed or blocked by mutations of the core nucleotides in the IFN-gamma activation site sequence and by overexpression of the STAT-1 inhibitor PIAS1 or the dominant negative phospho-STAT-1 mutations at Tyr-701 and/or Ser-727 residues. Serine 291-294 interferon gamma Homo sapiens 136-145 18566422-7 2008 Because IFN-gamma was lower in siIL-32-treated PBMC, we blocked IFN-gamma bioactivity, which enhanced the augmentation of p24 by siIL-32. siil 31-35 interferon gamma Homo sapiens 8-17 18566422-7 2008 Because IFN-gamma was lower in siIL-32-treated PBMC, we blocked IFN-gamma bioactivity, which enhanced the augmentation of p24 by siIL-32. siil 31-35 interferon gamma Homo sapiens 64-73 18566422-7 2008 Because IFN-gamma was lower in siIL-32-treated PBMC, we blocked IFN-gamma bioactivity, which enhanced the augmentation of p24 by siIL-32. siil 129-133 interferon gamma Homo sapiens 8-17 18566422-7 2008 Because IFN-gamma was lower in siIL-32-treated PBMC, we blocked IFN-gamma bioactivity, which enhanced the augmentation of p24 by siIL-32. siil 129-133 interferon gamma Homo sapiens 64-73 18429930-0 2008 Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro. Aripiprazole 22-34 interferon gamma Homo sapiens 38-54 18231846-3 2008 In peripheral blood mononuclear cell cultures with CFA and 1,25(OH)(2)D(3), IL-12p40, and IFN-gamma levels were significantly decreased (p < 0.05) and IL-10 levels were significantly increased (p < 0.05) in patients with GG genotype. 3-chloro-4-fluoroaniline 51-54 interferon gamma Homo sapiens 90-99 18549680-1 2008 Saponinum album, a mixture of triterpenoic saponins derived from Gypsophila species, led to an increased internalization of agrostin, a ribosome-inactivating-protein (RIP) type I in U-937 cells differentiated with interferon-gamma or phorbol myristate acetate. saponinum album 0-15 interferon gamma Homo sapiens 214-230 18549680-1 2008 Saponinum album, a mixture of triterpenoic saponins derived from Gypsophila species, led to an increased internalization of agrostin, a ribosome-inactivating-protein (RIP) type I in U-937 cells differentiated with interferon-gamma or phorbol myristate acetate. agrostin 124-132 interferon gamma Homo sapiens 214-230 18429930-7 2008 As a result, we can speculate that aripiprazole may inhibit IFN-gamma-induced microglial activation through the suppression of IFN-gamma-induced elevation of [Ca(2+)](i) in microglia. Aripiprazole 35-47 interferon gamma Homo sapiens 60-69 18429930-7 2008 As a result, we can speculate that aripiprazole may inhibit IFN-gamma-induced microglial activation through the suppression of IFN-gamma-induced elevation of [Ca(2+)](i) in microglia. Aripiprazole 35-47 interferon gamma Homo sapiens 127-136 18667035-1 2008 Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) was proven to induce IFN-gamma-dependent lethal anaphylactic reaction in T. gondii-infected mice through an alternative PAF-mediated pathway, but not the classical immunoglobulin (Ig)E-dependent pathway. Platelet Activating Factor 180-183 interferon gamma Homo sapiens 81-90 18667035-2 2008 Although marked IFN-gamma production was observed by CD11b(+), CD11c(+), CD4(+) and CD8(+) splenocytes, CD11b(+) and CD11c(+) cells were shown to be the key effecter cells which generated pro-inflammatory lipid such as PAF and caused T.g.HSP70-induced anaphylactic reaction. Platelet Activating Factor 219-222 interferon gamma Homo sapiens 16-25 18298587-4 2008 Patients with increased creatinine had less frequently detectable CD3+CD4+CD25+IFN-gamma+ PBL than patients with good graft function (P = 0.017). Creatinine 24-34 interferon gamma Homo sapiens 79-88 18574148-6 2008 We further show that Stat1 mutants lacking the ability to stably associate with chromatin are poorly serine-phosphorylated in response to IFN-gamma. Serine 101-107 interferon gamma Homo sapiens 138-147 18457828-6 2008 Exposure of cells to either IFNgamma or TNFalpha caused increased production of reactive oxygen species and transient phosphorylation of extracellular signal-regulated kinase (Erk1/2). Reactive Oxygen Species 80-103 interferon gamma Homo sapiens 28-36 18435915-4 2008 The study revealed that isoeleutherin, which has 1,4-naphthoquinone ring with alpha-methyl group, selectively and specifically stimulated IFNgamma production through the activation of T-bet gene transcription, thus enhancing Th1-mediated immune responses. isoeleutherin 24-37 interferon gamma Homo sapiens 138-146 18435915-4 2008 The study revealed that isoeleutherin, which has 1,4-naphthoquinone ring with alpha-methyl group, selectively and specifically stimulated IFNgamma production through the activation of T-bet gene transcription, thus enhancing Th1-mediated immune responses. 1,4-naphthoquinone 49-67 interferon gamma Homo sapiens 138-146 18435915-5 2008 However, a natural naphthopyran-4-one, eleutherinol dramatically inhibited both IFNgamma and IL-2 productions during Th cell activation by suppressing the gene transcriptions of cytokines. naphthopyran-4-one 19-37 interferon gamma Homo sapiens 80-88 18435915-5 2008 However, a natural naphthopyran-4-one, eleutherinol dramatically inhibited both IFNgamma and IL-2 productions during Th cell activation by suppressing the gene transcriptions of cytokines. eleutherinol 39-51 interferon gamma Homo sapiens 80-88 18440651-9 2008 Preincubation with IFN-gamma resulted in enhanced GM-CSF- or IL-5-induced superoxide anion generation and degranulation of human eosinophils, whereas stimulus-induced eosinophil adhesion was unaffected. Superoxides 74-90 interferon gamma Homo sapiens 19-28 18388182-6 2008 Further studies indicated that stimulation with ESAT-6 directly induced purified gammadelta T cells to produce IFN-gamma, independent of both antigen-presenting cells and CD4(+) T cells. esat-6 48-54 interferon gamma Homo sapiens 111-120 18440651-12 2008 Finally, we confirmed that MAPK inhibitors blocked the enhancement of stimuli-induced superoxide anion generation of IFN-gamma treated eosinophils. Superoxides 86-102 interferon gamma Homo sapiens 117-126 18440651-13 2008 In conclusion, IFN-gamma might upregulate ERK, p38, or JNK/ATF-2 phosphorylation induced by GM-CSF or IL-5, leading to enhanced cytokine-induced eosinophil superoxide generation and degranulation. Superoxides 156-166 interferon gamma Homo sapiens 15-24 18457922-1 2008 Intrathecal production of neopterin, a pteridine produced by interferon (IFN)-gamma-stimulated monocyte-derived macrophages, is associated with neurological disorders and infections. Neopterin 26-35 interferon gamma Homo sapiens 61-83 18457922-1 2008 Intrathecal production of neopterin, a pteridine produced by interferon (IFN)-gamma-stimulated monocyte-derived macrophages, is associated with neurological disorders and infections. Pteridines 39-48 interferon gamma Homo sapiens 61-83 18457922-2 2008 We investigated whether IFN-alpha/beta, IFN-gamma, or human immunodeficiency virus (HIV) induce neopterin production by human astroglioma cells. Neopterin 96-105 interferon gamma Homo sapiens 40-49 18457922-3 2008 IFN-alpha/beta and IFN-gamma, but not HIV, induced neopterin. Neopterin 51-60 interferon gamma Homo sapiens 19-28 18457922-4 2008 Interestingly, IFN-gamma, but not IFN-alpha/beta, increased expression and activity of the tryptophan-catabolizing enzyme indoleamine (2,3)-dioxygenase. Tryptophan 91-101 interferon gamma Homo sapiens 15-24 18457922-4 2008 Interestingly, IFN-gamma, but not IFN-alpha/beta, increased expression and activity of the tryptophan-catabolizing enzyme indoleamine (2,3)-dioxygenase. indolamine 122-133 interferon gamma Homo sapiens 15-24 18568766-4 2008 In addition, after treatment with CpG-ODN, the cytotoxic activity of the PBMCs and the production of IFN-gamma in CD8(+) T cells were dramatically enhanced. CPG-oligonucleotide 34-41 interferon gamma Homo sapiens 101-110 18218996-9 2008 The magnitude of the LPS-mediated proliferative effect in CBMC directly correlated to the level of induction of IFN-gamma (P < 0.01), but inversely correlated to the induced levels of IL-4 and IL-13 (P < 0.01 and P = 0.01, respectively). cbmc 58-62 interferon gamma Homo sapiens 112-121 18422734-8 2008 However, when measuring the Th2 cytokine-production capacity post-stimulation, a significant increase in the percentage of IL-4-producing T cells was observed in the IS groups, compared with the MC group, resulting in a significantly lower ratio of IFN-gamma-/IL-4-producing T cells. Methylcholanthrene 195-197 interferon gamma Homo sapiens 249-258 18230685-4 2008 We show, in lung A549 epithelial cells, that the tumor necrosis factor-alpha (TNF-alpha) and IFNgamma synergistically induced protein release and mRNA expression of CX(3)CL1 is inhibited by dexamethasone, without interfering with cytokine-induced nuclear translocation of NF-kappaB, and by an inhibitor of IkappaB kinase 2, AS602868. Dexamethasone 190-203 interferon gamma Homo sapiens 93-101 18230685-4 2008 We show, in lung A549 epithelial cells, that the tumor necrosis factor-alpha (TNF-alpha) and IFNgamma synergistically induced protein release and mRNA expression of CX(3)CL1 is inhibited by dexamethasone, without interfering with cytokine-induced nuclear translocation of NF-kappaB, and by an inhibitor of IkappaB kinase 2, AS602868. AS602868 324-332 interferon gamma Homo sapiens 93-101 18230685-6 2008 Chromatin immunoprecipitation assays showed a 5-fold increase in the recruitment of NF-kappaB to the CX(3)CL1 gene promoter in response to IFNgamma/TNF-alpha; this too was reversed by dexamethasone. Dexamethasone 184-197 interferon gamma Homo sapiens 139-147 18571002-8 2008 Culturing AMP cells with IFN-gamma did not reverse this result and did not upregulate class II expression. Adenosine Monophosphate 10-13 interferon gamma Homo sapiens 25-34 18442800-7 2008 Interestingly, CD3+CD56+ NKT-like cells from IL-15-cocultured CBMCs had significantly lower apoptotic frequency and higher levels of activation markers (CD161, CD25, and IFN-gamma) than those from IL-2-cocultured CBMCs. cbmcs 62-67 interferon gamma Homo sapiens 170-179 18217958-5 2008 In addition, real-time polymerase chain reaction showed that DHMEQ decreased PHA-stimulated expression of T helper type 1 (Th1) cytokines, including interleukin-2, interferon-gamma, and tumour necrosis factor alpha, in PBMC as well as Jurkat T-lymphoblastic leukaemia cells, and also decreased levels of p65 isoforms of NF-kappaB in the nucleus. dehydroxymethylepoxyquinomicin 61-66 interferon gamma Homo sapiens 164-214 18560127-9 2008 Acetylcholinesterase inhibitor pyridostigmine bromide (AChEI)-therapy reduced CCR2, CCR5, RANTES and IFNgamma expression and production in AD patients. Pyridostigmine Bromide 31-53 interferon gamma Homo sapiens 101-109 18497994-4 2008 In the present study, we found that the cytokine interferon-gamma (IFN-gamma) suppresses the basal, the heat shock-induced and the cisplatin-induced expression of Hsp27 in HSC-2 (oral squamous carcinoma) and A549 (lung cancer) cells but not in 16HBE14o- (normal bronchial epithelial cells). Cisplatin 131-140 interferon gamma Homo sapiens 49-65 18497994-4 2008 In the present study, we found that the cytokine interferon-gamma (IFN-gamma) suppresses the basal, the heat shock-induced and the cisplatin-induced expression of Hsp27 in HSC-2 (oral squamous carcinoma) and A549 (lung cancer) cells but not in 16HBE14o- (normal bronchial epithelial cells). Cisplatin 131-140 interferon gamma Homo sapiens 67-76 18497994-7 2008 More importantly, pre-treatment of cells with IFN-gamma enhanced the induction of cell death by hyperthermia and cisplatin treatments in the tumor cell lines, HSC-2 and A549, but has no effect in 16HBE14o-, indicating a tumor cell-specific effect of IFN-gamma. Cisplatin 113-122 interferon gamma Homo sapiens 46-55 18497994-7 2008 More importantly, pre-treatment of cells with IFN-gamma enhanced the induction of cell death by hyperthermia and cisplatin treatments in the tumor cell lines, HSC-2 and A549, but has no effect in 16HBE14o-, indicating a tumor cell-specific effect of IFN-gamma. Cisplatin 113-122 interferon gamma Homo sapiens 250-259 18497994-9 2008 Together, our findings propose that IFN-gamma could be a useful potentiator of hyperthermia and cisplatin in cancer therapy. Cisplatin 96-105 interferon gamma Homo sapiens 36-45 18669138-5 2008 Eight of the 10 patients with positive IFN-gamma test results had a less severe course of the disease, with fast reduction in steroid dosage. Steroids 126-133 interferon gamma Homo sapiens 39-48 18242062-1 2008 The immunomodulator, AS101, inhibits production of IL-10, IL-4 and expression of p38 MAPK, while increasing production of IFNgamma and IL-2. ammonium trichloro(dioxoethylene-O,O'-)tellurate 21-26 interferon gamma Homo sapiens 122-130 18497880-8 2008 Furthermore, the IFN-gamma produced by LPMCs triggered further abnormal macrophage differentiation with an IL-23-hyperproducing phenotype. lpmcs 39-44 interferon gamma Homo sapiens 17-26 18655544-6 2008 The oligosaccharide also stimulated interferon-gamma production by human peripheral blood lymphocyte in vitro, indicating that it may activate the immunological pathways and suppress the growth of tumors in vivo. Oligosaccharides 4-19 interferon gamma Homo sapiens 36-52 18482439-7 2008 Interestingly, all subjects with positive patch test to both nickel and palladium (group 3) showed an in vitro response characterized by the release of IFN-gamma after nickel stimulation and production of IL-10 in response to palladium. Nickel 61-67 interferon gamma Homo sapiens 152-161 18221253-1 2008 Indoleamine 2,3-dioxygenase (IDO) is an interferon-gamma-inducible intracellular enzyme which catalyses the catabolism of tryptophan. Tryptophan 122-132 interferon gamma Homo sapiens 40-56 18334227-7 2008 IFN-gamma secretion from naive T cells co-cultured with DC differentiated with LPS was also augmented by 16-phyllocladanol. 16-phyllocladanol 105-122 interferon gamma Homo sapiens 0-9 18482439-0 2008 Nickel, palladium and rhodium induced IFN-gamma and IL-10 production as assessed by in vitro ELISpot-analysis in contact dermatitis patients. Nickel 0-6 interferon gamma Homo sapiens 38-47 18482439-0 2008 Nickel, palladium and rhodium induced IFN-gamma and IL-10 production as assessed by in vitro ELISpot-analysis in contact dermatitis patients. Palladium 8-17 interferon gamma Homo sapiens 38-47 18482439-4 2008 The production of IFN-gamma and IL-10 elicited by metal compounds were analyzed by the ELISpot assay. Metals 50-55 interferon gamma Homo sapiens 18-27 18482439-7 2008 Interestingly, all subjects with positive patch test to both nickel and palladium (group 3) showed an in vitro response characterized by the release of IFN-gamma after nickel stimulation and production of IL-10 in response to palladium. Palladium 72-81 interferon gamma Homo sapiens 152-161 18482439-5 2008 RESULTS: We found a specific IFN-gamma response by PBMC upon in vitro stimulation with nickel or palladium in well recognized allergic individuals. Nickel 87-93 interferon gamma Homo sapiens 29-38 18482439-5 2008 RESULTS: We found a specific IFN-gamma response by PBMC upon in vitro stimulation with nickel or palladium in well recognized allergic individuals. Palladium 97-106 interferon gamma Homo sapiens 29-38 18482439-7 2008 Interestingly, all subjects with positive patch test to both nickel and palladium (group 3) showed an in vitro response characterized by the release of IFN-gamma after nickel stimulation and production of IL-10 in response to palladium. Nickel 168-174 interferon gamma Homo sapiens 152-161 18316202-4 2008 In the present study, we examined the effect of dexamethasone (Dex) on constitutive and TNF-alpha- and IFN-gamma-induced BAFF expression in FLS-RA. Dexamethasone 63-66 interferon gamma Homo sapiens 103-112 18453621-4 2008 Simvastatin also induced IFN-gamma, IL-4, and IL-27 production in monocytes, which together inhibited IL-17 transcription and secretion in CD4(+) T cells. Simvastatin 0-11 interferon gamma Homo sapiens 25-34 18211896-8 2008 Surface expression of annexin 2 was reduced in cells treated with glyburide, an ABCA1 inhibitor, whereas inhibition of calpain abrogated IFNgamma-induced annexin 2 down-regulation and suppression of Matrigel invasion. Glyburide 66-75 interferon gamma Homo sapiens 137-145 18646554-0 2008 Influence of interferon-alpha and ribavirin on the transcription of interferon-gamma and IFN-gamma receptor genes in Jurkat cells. Ribavirin 34-43 interferon gamma Homo sapiens 68-84 18646554-0 2008 Influence of interferon-alpha and ribavirin on the transcription of interferon-gamma and IFN-gamma receptor genes in Jurkat cells. Ribavirin 34-43 interferon gamma Homo sapiens 89-98 18646554-3 2008 In the presented study, using Jurkat cell line as an in vitro model for interferon-gamma synthesis, influence of interferon-alpha and ribavirin on the expressions of IFN-gamma and its receptor subunits (IFNgR1 and IFNgR2) were studied. Ribavirin 134-143 interferon gamma Homo sapiens 166-175 18646554-5 2008 Results indicate that both drugs, IFN-alpha and ribavirin, induced changes in IFN-gamma and its receptor expressions. Ribavirin 48-57 interferon gamma Homo sapiens 78-87 18646554-7 2008 The inhibitory effect of ribavirin dominated IFN-alpha action and was responsible for the decrease in the mRNA levels of IFN-gamma and the receptor of IFN-gamma. Ribavirin 25-34 interferon gamma Homo sapiens 121-130 18646554-7 2008 The inhibitory effect of ribavirin dominated IFN-alpha action and was responsible for the decrease in the mRNA levels of IFN-gamma and the receptor of IFN-gamma. Ribavirin 25-34 interferon gamma Homo sapiens 151-160 18646554-8 2008 This phenomenon observed at in vitro model may be responsible for the IFN-gamma decrease during hepatitis C therapy with IFN-alpha and ribavirin which was suggested by some authors. Ribavirin 135-144 interferon gamma Homo sapiens 70-79 18387520-7 2008 While overnight incubation of HCMC with IgE significantly increased the expression of NOS2 and NOS3, only NOS2 expression was up-regulated after overnight incubation with a mixture of TNF-alpha, IFN-gamma and IL-1beta. hcmc 30-34 interferon gamma Homo sapiens 195-204 18412158-0 2008 Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: a nitric oxide regulatory feedback mechanism. Nitric Oxide 75-87 interferon gamma Homo sapiens 0-16 18705328-0 2008 Effect of interferon-gamma on hepatic stellate cells stimulated by acetaldehyde. Acetaldehyde 67-79 interferon gamma Homo sapiens 10-26 18705328-2 2008 Although, it is considered that IFN-gamma inhibits the transcription of matrix, it has not been well defined whether IFN-gamma could inhibit the expression of matrix induced by acetaldehyde in METHODOLOGY: HSC were divided into 5 groups, 4 groups were treated with different doses (0, 1000, 1500, 2000 IU/mL) of IFN-gamma and acetaldehyde (200pM) for 24 and 48 h. For the control group, HSC were treated only with medium. Acetaldehyde 177-189 interferon gamma Homo sapiens 117-126 18705328-2 2008 Although, it is considered that IFN-gamma inhibits the transcription of matrix, it has not been well defined whether IFN-gamma could inhibit the expression of matrix induced by acetaldehyde in METHODOLOGY: HSC were divided into 5 groups, 4 groups were treated with different doses (0, 1000, 1500, 2000 IU/mL) of IFN-gamma and acetaldehyde (200pM) for 24 and 48 h. For the control group, HSC were treated only with medium. Acetaldehyde 177-189 interferon gamma Homo sapiens 117-126 18705328-7 2008 CONCLUSIONS: The present data indicated that IFN-gamma could inhibit the collagen expression in HSC stimulated by acetaldehyde. Acetaldehyde 114-126 interferon gamma Homo sapiens 45-54 18705328-8 2008 IFN-gamma could down-regulate the TGF-beta1, Smad4 and especially TGFbetaRI in HSC after acetaldehyde stimulation. Acetaldehyde 89-101 interferon gamma Homo sapiens 0-9 18705328-9 2008 This experiment showed 1000, 1500, 2000 IU/mL IFN-gamma were effective and safe to down-regulate the extracellular matrix induced by acetaldehyde in vitro. Acetaldehyde 133-145 interferon gamma Homo sapiens 46-55 17945348-2 2008 Interferon-gamma (IFN-gamma) triggers several antiviral mechanisms in target cells including the induction of indoleamine-2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan to kynurenine. essential amino acid tryptophan 164-195 interferon gamma Homo sapiens 0-16 17945348-2 2008 Interferon-gamma (IFN-gamma) triggers several antiviral mechanisms in target cells including the induction of indoleamine-2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan to kynurenine. essential amino acid tryptophan 164-195 interferon gamma Homo sapiens 18-27 17945348-2 2008 Interferon-gamma (IFN-gamma) triggers several antiviral mechanisms in target cells including the induction of indoleamine-2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan to kynurenine. Kynurenine 199-209 interferon gamma Homo sapiens 0-16 17945348-2 2008 Interferon-gamma (IFN-gamma) triggers several antiviral mechanisms in target cells including the induction of indoleamine-2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan to kynurenine. Kynurenine 199-209 interferon gamma Homo sapiens 18-27 17945348-7 2008 Serum concentrations of neopterin, indicating Th-1 mediated immune activation via IFN-gamma, were positively correlated to enhanced tryptophan degradation (rs=0.650, p<0.001) in patients, but not in healthy individuals. Neopterin 24-33 interferon gamma Homo sapiens 82-91 18547161-0 2008 Lung function and IFN-gamma levels in the sera of silica-exposed workers. Silicon Dioxide 50-56 interferon gamma Homo sapiens 18-27 18395499-6 2008 Using our method, we found tryptophan metabolites in the cells and the culture medium of LN229 human glioma cells were stimulated by interferon-gamma, a known inducer of indoleamine 2,3-dioxygenase. Tryptophan 27-37 interferon gamma Homo sapiens 133-149 18420276-1 2008 OBJECTIVE: Neopterin is generated and released in increased amounts by macrophages upon activation by interferon-gamma during cellular immune response. Neopterin 11-20 interferon gamma Homo sapiens 102-118 18547161-4 2008 The aim of the present study was to investigate serum IFN-gamma levels and pulmonary function changes in silica-exposed workers and in silicosis. Silicon Dioxide 105-111 interferon gamma Homo sapiens 54-63 18547161-8 2008 The mean serum IFN-gamma level was increased in silica-exposed workers (10.22 +/- 22.68 pg/mL) although it was undetectable in all office workers and even in the workers with silicosis. Silicon Dioxide 48-54 interferon gamma Homo sapiens 15-24 18547161-10 2008 Although serum IFN-gamma may increase initially in response to silica, low levels of IFN-gamma in later stages may be considered a risk factor for silicosis because this cytokine downregulates the fibroblast responses to transforming growth factor-beta (TGF-beta) and decreases collagen production. Silicon Dioxide 63-69 interferon gamma Homo sapiens 15-24 18329891-5 2008 Sixty percent of the total hIFN-gamma was secreted to the periplasm using the SP3 signal peptide and a post-induction temperature of 20 degrees C. Using Tris-sucrose-dithiothreitol (TSD) hypertonic buffer, the periplasmic soluble hINF-gamma was recovered with a purity of 85%. tris-sucrose-dithiothreitol 153-180 interferon gamma Homo sapiens 27-37 18569454-4 2008 Synergistic induction of CXCL10 by both Tat and IFN-gamma was susceptible to inhibition by the MEK1/2 inhibitor U0126 and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580. U 0126 112-117 interferon gamma Homo sapiens 48-57 18569454-4 2008 Synergistic induction of CXCL10 by both Tat and IFN-gamma was susceptible to inhibition by the MEK1/2 inhibitor U0126 and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580. SB 203580 180-188 interferon gamma Homo sapiens 48-57 18265948-13 2008 Moreover, CAPE reduces the mRNA expressions of TNF-alpha and IFN-gamma in diabetic brain; suggesting CAPE suppresses inflammation as well as oxidative stress occurred in the brain of diabetic patients. caffeic acid phenethyl ester 10-14 interferon gamma Homo sapiens 61-70 18265948-13 2008 Moreover, CAPE reduces the mRNA expressions of TNF-alpha and IFN-gamma in diabetic brain; suggesting CAPE suppresses inflammation as well as oxidative stress occurred in the brain of diabetic patients. caffeic acid phenethyl ester 101-105 interferon gamma Homo sapiens 61-70 18430759-4 2008 Could the observed IFN-gamma-mediated inhibition of EVT outgrowth and migration be related to either expression changes of IGF-1 or IGF-2, their receptors, their binding proteins, or apoptosis? EVT 52-55 interferon gamma Homo sapiens 19-28 18430759-7 2008 In EVT, IFN-gamma decreased IGFR-2, but not IGFR-1 expression. EVT 3-6 interferon gamma Homo sapiens 8-17 18430759-9 2008 IFN-gamma induced trophoblast apoptosis measured by the highly sensitive M30 neo-epitope, but not caspase 3 activity, in conditioned medium and EVT cell lysates. EVT 144-147 interferon gamma Homo sapiens 0-9 18430759-10 2008 The observed IFN-gamma-mediated EVT migration inhibition may occur through the down-regulation of IGFR-2 and subtle induction of EVT apoptosis. EVT 32-35 interferon gamma Homo sapiens 13-22 18430759-10 2008 The observed IFN-gamma-mediated EVT migration inhibition may occur through the down-regulation of IGFR-2 and subtle induction of EVT apoptosis. EVT 129-132 interferon gamma Homo sapiens 13-22 18416830-1 2008 BACKGROUND: We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-gamma and TNF-alpha expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Tretinoin 47-70 interferon gamma Homo sapiens 170-179 18416830-1 2008 BACKGROUND: We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-gamma and TNF-alpha expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Tretinoin 72-76 interferon gamma Homo sapiens 170-179 18416830-1 2008 BACKGROUND: We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-gamma and TNF-alpha expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Alitretinoin 82-101 interferon gamma Homo sapiens 170-179 17982491-4 2008 Here, we show that OBP-301 replication produced the endogenous danger signaling molecule, uric acid, in infected human tumor cells, which in turn stimulated DCs to produce interferon-gamma (IFN-gamma) and interleukin 12 (IL-12). Uric Acid 90-99 interferon gamma Homo sapiens 172-188 18272812-6 2008 Blocking IFN-gamma or disrupting STAT1 partially impaired suppression by MO-MDSCs, for which nitric oxide (NO) was one of the mediators. Nitric Oxide 93-105 interferon gamma Homo sapiens 9-18 17982491-4 2008 Here, we show that OBP-301 replication produced the endogenous danger signaling molecule, uric acid, in infected human tumor cells, which in turn stimulated DCs to produce interferon-gamma (IFN-gamma) and interleukin 12 (IL-12). Uric Acid 90-99 interferon gamma Homo sapiens 190-199 17947510-1 2008 We have previously shown that long-term treatment of airway smooth muscle (ASM) cells with a combination of TNF-alpha and IFN-gamma impaired steroid anti-inflammatory action through the up-regulation of glucocorticoid receptor beta isoform (GRbeta) (Mol Pharmacol 2006;69:588-596). Steroids 141-148 interferon gamma Homo sapiens 122-131 17947510-2 2008 We here found that steroid actions could also be suppressed by short-term exposure of ASM cells to TNF-alpha and IFN-gamma (6 h) as shown by the abrogated glucocorticoid responsive element (GRE)-dependent gene transcription; surprisingly, neither GRalpha nuclear translocation nor GRbeta expression was affected by cytokine mixture. Steroids 19-26 interferon gamma Homo sapiens 113-122 17641822-10 2008 Th 1 cells of CD4(+) sub-population are more responsive to Cd than Th 2, leading to higher suppression of IL-2 and IFNgamma than IL-4 and hence, the study unravels to some extend, the underlying events involved in Cd immunotoxicity. Cadmium 59-61 interferon gamma Homo sapiens 115-123 17947510-5 2008 Interestingly, the capacity of fluticasone to completely inhibit TNF-alpha-induced IRF-1 expression, IRF-1 DNA binding, and transactivation activities was completely lost in cells exposed to TNF-alpha and IFN-gamma in combination. Fluticasone 31-42 interferon gamma Homo sapiens 205-214 18239149-0 2008 A new mechanism involving ERK contributes to rosiglitazone inhibition of tumor necrosis factor-alpha and interferon-gamma inflammatory effects in human endothelial cells. Rosiglitazone 45-58 interferon gamma Homo sapiens 105-121 18524170-8 2008 In addition, primed splenocytes produced a CD8+ IFNgamma response to gB. gb 69-71 interferon gamma Homo sapiens 48-56 18350544-4 2008 The CD4 subset stimulated by alpha-galactosylceramide (alpha-GalCer)-loaded DC immediately produced massive amounts of IL-4 and IL-13, which together with IFN-gamma enhanced CD40L-induced IL-12 production by DC. alpha-galactosylceramide 29-53 interferon gamma Homo sapiens 155-164 18350544-4 2008 The CD4 subset stimulated by alpha-galactosylceramide (alpha-GalCer)-loaded DC immediately produced massive amounts of IL-4 and IL-13, which together with IFN-gamma enhanced CD40L-induced IL-12 production by DC. alpha-galactosylceramide 55-67 interferon gamma Homo sapiens 155-164 18291365-10 2008 Given the pivotal role of IFNgamma-induced chemokines in Th1-mediated allograft rejection, these preliminary results suggest that the combined effects of immunosuppressive agents and rosiglitazone could be potentially beneficial to patients receiving heart transplants. Rosiglitazone 183-196 interferon gamma Homo sapiens 26-34 18395083-10 2008 CD8(+) T-cell lines released both granzyme-B and interferon-gamma following recognition of pA2 when presented by Caco2 and not by HT29. caco2 113-118 interferon gamma Homo sapiens 49-65 18171698-7 2008 Upon hCG treatment, IDO mRNA expression and its metabolite kynurenine were increased by LPS- and IFN-gamma-stimulated DC, suggesting its involvement in the decreased T cell proliferation. Kynurenine 59-69 interferon gamma Homo sapiens 97-106 18162507-5 2008 Obestatin exerted proliferative, survival, and antiapoptotic effects under serum-deprived conditions and interferon-gamma/tumor necrosis factor-alpha/interleukin-1 beta treatment, particularly at pharmacological concentrations. Ghrelin 0-9 interferon gamma Homo sapiens 105-149 17942160-3 2008 The tryptophan catabolism enzyme indoleamine 2,3-dioxygenase (IDO) is interferon-gamma (IFN-gamma)-inducible and has recently become a focus for maternal-fetal tolerance for successful pregnancy. Tryptophan 4-14 interferon gamma Homo sapiens 70-86 17942160-3 2008 The tryptophan catabolism enzyme indoleamine 2,3-dioxygenase (IDO) is interferon-gamma (IFN-gamma)-inducible and has recently become a focus for maternal-fetal tolerance for successful pregnancy. Tryptophan 4-14 interferon gamma Homo sapiens 88-97 18242001-10 2008 However, in a persistently fatigued subgroup, sensitivity to DEX was significantly reduced on the level of interferon (IFN)-gamma production. Dexamethasone 61-64 interferon gamma Homo sapiens 107-129 18250155-2 2008 During an investigation of the growth-suppressive effects of interferons (IFNs), we noticed that cebpb(-/-) cells fail to undergo apoptosis upon gamma IFN (IFN-gamma) treatment, compared to wild-type controls. cebpb 97-102 interferon gamma Homo sapiens 74-77 18250155-2 2008 During an investigation of the growth-suppressive effects of interferons (IFNs), we noticed that cebpb(-/-) cells fail to undergo apoptosis upon gamma IFN (IFN-gamma) treatment, compared to wild-type controls. cebpb 97-102 interferon gamma Homo sapiens 156-165 18381516-11 2008 The ratio of T-cell mitogen-induced interferon-gamma/interleukin-4 secretion was significantly higher in the dexamethasone group than in the hydrocortisone group. Dexamethasone 109-122 interferon gamma Homo sapiens 36-52 18381516-11 2008 The ratio of T-cell mitogen-induced interferon-gamma/interleukin-4 secretion was significantly higher in the dexamethasone group than in the hydrocortisone group. Hydrocortisone 141-155 interferon gamma Homo sapiens 36-52 18381516-12 2008 Interferon-gamma production and the ratios of interferon-gamma/interleukin-4 and interferon-gamma/ interleukin-10 were significantly higher in the dexamethasone group than the reference group. Dexamethasone 147-160 interferon gamma Homo sapiens 0-16 18381516-12 2008 Interferon-gamma production and the ratios of interferon-gamma/interleukin-4 and interferon-gamma/ interleukin-10 were significantly higher in the dexamethasone group than the reference group. Dexamethasone 147-160 interferon gamma Homo sapiens 46-62 18381516-12 2008 Interferon-gamma production and the ratios of interferon-gamma/interleukin-4 and interferon-gamma/ interleukin-10 were significantly higher in the dexamethasone group than the reference group. Dexamethasone 147-160 interferon gamma Homo sapiens 81-97 18664200-3 2008 The modulation of cetirizine on the production of interferon (IFN)-gamma, interleukin (IL)-1beta, IL-6 and IL-8 in HaCaT cells and fibroblasts was measured by ELISA. Cetirizine 18-28 interferon gamma Homo sapiens 50-72 18164543-0 2008 N-(4-Hydroxyphenyl)retinamide induced differentiation with repression of telomerase and cell cycle to increase interferon-gamma sensitivity for apoptosis in human glioblastoma cells. Fenretinide 0-29 interferon gamma Homo sapiens 111-127 18337667-10 2008 Cytokine gene expression of the allografts treated with ciprofloxacin was higher with respect to transforming growth factor-beta and equal with respect to tumor necrosis factor-alpha and interferon-gamma compared with controls. Ciprofloxacin 56-69 interferon gamma Homo sapiens 187-203 18337667-11 2008 When applied in combination with cyclosporine A, ciprofloxacin lowered the expression of transforming growth factor-beta and tumor necrosis factor-alpha and increased interferon-gamma expression. Cyclosporine 33-47 interferon gamma Homo sapiens 167-183 18337667-11 2008 When applied in combination with cyclosporine A, ciprofloxacin lowered the expression of transforming growth factor-beta and tumor necrosis factor-alpha and increased interferon-gamma expression. Ciprofloxacin 49-62 interferon gamma Homo sapiens 167-183 18337671-12 2008 PUVA-treated mo-DCs skewed naive T cells toward a Th2 response as defined by increased IL-4, IL-10, and IL-13 and decreased interferon-gamma levels, and the expression of the Th2-associated chemokine receptors CCR4 and CCR10. puva 0-4 interferon gamma Homo sapiens 124-140 18320029-7 2008 Importantly, sustained transmembranous calcium flux, activation of Src-kinases as well as activation of PI3K were found to be absolutely required for CD28SA-mediated production of IFN-gamma and IL-2. Calcium 39-46 interferon gamma Homo sapiens 180-189 18178718-4 2008 The induction of ICAM-1 in response to IFN-gamma was inhibited by JWH-015. JHW 015 66-73 interferon gamma Homo sapiens 39-48 18239058-7 2008 An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed IL-1beta-, IFN-gamma-, and TNF-alpha-induced IL-32alpha mRNA expression, although MAPK inhibitors had no effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 47-55 interferon gamma Homo sapiens 93-102 18239058-9 2008 Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha-induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma-induced activated protein-1 (AP-1) activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 interferon gamma Homo sapiens 122-131 18164543-3 2008 N-(4-Hydroxyphenyl)retinamide (4-HPR) induced astrocytic differentiation and increased sensitivity to interferon-gamma (IFN-gamma) for apoptosis in human glioblastoma A172, LN18, and SNB19 cells. Fenretinide 0-29 interferon gamma Homo sapiens 102-118 18164543-3 2008 N-(4-Hydroxyphenyl)retinamide (4-HPR) induced astrocytic differentiation and increased sensitivity to interferon-gamma (IFN-gamma) for apoptosis in human glioblastoma A172, LN18, and SNB19 cells. Fenretinide 0-29 interferon gamma Homo sapiens 120-129 18249037-0 2008 Increase in B-cell-activation factor (BAFF) and IFN-gamma productions by tonsillar mononuclear cells stimulated with deoxycytidyl-deoxyguanosine oligodeoxynucleotides (CpG-ODN) in patients with IgA nephropathy. deoxycytidyl-deoxyguanosine oligodeoxynucleotides 117-166 interferon gamma Homo sapiens 48-57 18190601-12 2008 Imatinib did not influence interleukin-2 and tumour necrosis factor-alpha production but increased interferon-gamma production. Imatinib Mesylate 0-8 interferon gamma Homo sapiens 99-115 18249037-0 2008 Increase in B-cell-activation factor (BAFF) and IFN-gamma productions by tonsillar mononuclear cells stimulated with deoxycytidyl-deoxyguanosine oligodeoxynucleotides (CpG-ODN) in patients with IgA nephropathy. CPG-oligonucleotide 168-175 interferon gamma Homo sapiens 48-57 18249037-5 2008 In this study, we focused on roles of BAFF and IFN-gamma in IgA production of TMCs stimulated with CpG-ODN in IgAN patients. trimethylsilyl chloride 78-82 interferon gamma Homo sapiens 47-56 18249037-7 2008 The spontaneous productions of IgA and IFN-gamma of TMCs were significantly higher in IgAN patients than in non-IgAN patients (p=0.023 and p=0.02). trimethylsilyl chloride 52-56 interferon gamma Homo sapiens 39-48 18249037-8 2008 Under stimulation with CpG-ODN, the productions of IgA, BAFF and IFN-gamma of TMCs were significantly higher in IgAN patients than in non-IgAN patients (p=0.013, p=0.005 and p=0.039). trimethylsilyl chloride 78-82 interferon gamma Homo sapiens 65-74 18249037-9 2008 The IgA production of TMCs stimulated by CpG-ODN was inhibited by the treatment with anti-BAFF antibody and/or anti-IFN-gamma antibody. trimethylsilyl chloride 22-26 interferon gamma Homo sapiens 116-125 18249037-10 2008 Under stimulation with IFN-gamma, the BAFF expression on the CD1c cells and the BAFF production of TMCs were significantly higher in IgAN patients than in non-IgAN patients (p=0.004 and p=0.042). trimethylsilyl chloride 99-103 interferon gamma Homo sapiens 23-32 18205804-0 2008 Antimicrobial and immunoregulatory effects mediated by human lung cells: role of IFN-gamma-induced tryptophan degradation. Tryptophan 99-109 interferon gamma Homo sapiens 81-90 18205804-6 2008 Furthermore, the IFN-gamma-dependent antimicrobial effects of HBE4-E6/E7 (human lung bronchus epithelial cells) and A549 (human type II alveolar cells) correlated with the activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO). Tryptophan 190-200 interferon gamma Homo sapiens 17-26 18205804-7 2008 It was found that both the abrogation of IDO activity by the specific IDO-inhibitor 1-L-methyltryptophan and the supplementation of cultures with tryptophan result in an inhibition of IFN-gamma-induced antimicrobial effects mediated by lung cells. 1-l-methyltryptophan 84-104 interferon gamma Homo sapiens 184-193 18205804-7 2008 It was found that both the abrogation of IDO activity by the specific IDO-inhibitor 1-L-methyltryptophan and the supplementation of cultures with tryptophan result in an inhibition of IFN-gamma-induced antimicrobial effects mediated by lung cells. Tryptophan 94-104 interferon gamma Homo sapiens 184-193 18205804-8 2008 Therefore it is suggested that tryptophan depletion via IFN-gamma-mediated IDO induction is a major antibacterial, antiparasitic, antiviral and immunoregulatory mechanism in human lung cells. Tryptophan 31-41 interferon gamma Homo sapiens 56-65 18578365-6 2008 This concentration of basiliximab significantly augmented interferon (IFN)-gamma production of ELs when interleukin (IL)-2 was added on day 0 or on day 1 after basiliximab. N-[(2S,3S,4R)-3,4-dihydroxy-8-oxo-8-[(4-pentylphenyl)amino]-1-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octan-2-yl]hexacosanamide 95-98 interferon gamma Homo sapiens 58-80 18226915-6 2008 The significantly high levels of IFN-gamma and TauNuF-alpha in TB PF and their positive correlation with IP-10 and MIP-1alpha indicated their synergistic action to elicit a strong protective Th1 response. tb pf 63-68 interferon gamma Homo sapiens 33-42 18292514-6 2008 Engagement of 2DL4 was also shown to activate the transcription and translation of a variety of cytokine genes, including TNF-alpha, IFN-gamma, MIP1alpha, MIP1beta, and IL-8. 2dl4 14-18 interferon gamma Homo sapiens 133-142 18292514-7 2008 Pharmacological inhibitors of JNK, MEK1/2 and p38, blocked IFN-gamma, IL-8, and MIP1alpha production, suggesting that MAPKs are regulating 2DL4-mediated cytokine production in a nonredundant manner. 2dl4 139-143 interferon gamma Homo sapiens 59-68 18205751-7 2008 For example, CD4(+) and CD8(+) T cells possibly through their secretion of interferon-gamma, appear to play an important role in determining neuronal responses when challenged with kainic acid. Kainic Acid 181-192 interferon gamma Homo sapiens 75-91 18262659-3 2008 The culture study showed reduced IL-12, IL-17, IFN-gamma, GM-CSF, TNF-alpha and MIP-1beta, and elevated IL-10 in the PBMC from patients who received tacrolimus, which suggests inhibition of T cells and macrophages, and enhancement of type 1 regulatory T cells. Tacrolimus 149-159 interferon gamma Homo sapiens 47-56 18261039-7 2008 By contrast, PGE2-supplemented DC could be characterized by negligible responses to LPS and IFN-gamma and a remarkable NF-kappaB response to CD40L. Dinoprostone 13-17 interferon gamma Homo sapiens 92-101 18055568-3 2008 In this study, we show that cigarette smoke-conditioned medium (SCM) dose-dependently inhibits in vitro IFN-gamma production by polyinosinic:polycytidylic acid (poly I:C)-activated PBMC and NK cells isolated from nonsmoking individuals. Poly I-C 128-159 interferon gamma Homo sapiens 104-113 18055568-3 2008 In this study, we show that cigarette smoke-conditioned medium (SCM) dose-dependently inhibits in vitro IFN-gamma production by polyinosinic:polycytidylic acid (poly I:C)-activated PBMC and NK cells isolated from nonsmoking individuals. Poly I-C 161-169 interferon gamma Homo sapiens 104-113 18055568-6 2008 PBMC and NK cells isolated from smokers displayed significant reduction of IFN-gamma and TNF-alpha secretions compared with nonsmokers in response to poly I:C activation. Poly I-C 150-158 interferon gamma Homo sapiens 75-84 18302006-7 2008 In humans, only the CFA-induced IFN-gamma production and cell proliferation in the group of patients with actinomycetoma. 3-chloro-4-fluoroaniline 20-23 interferon gamma Homo sapiens 32-41 18443380-8 2008 The combination of AZT and IFNgamma, IL-2 or IL-4 also induced a stronger suppression of FLV RT activity than either cytokine or AZT used alone. Zidovudine 129-132 interferon gamma Homo sapiens 27-35 18194875-3 2008 Recently, we demonstrated that TGF-beta1 enhances astrocytic nitric oxide production induced by lipopolysaccharide (LPS) plus interferon-gamma (IFNgamma) by increasing the number of astrocytes in a population that express NOS-2. Nitric Oxide 61-73 interferon gamma Homo sapiens 126-142 18194875-3 2008 Recently, we demonstrated that TGF-beta1 enhances astrocytic nitric oxide production induced by lipopolysaccharide (LPS) plus interferon-gamma (IFNgamma) by increasing the number of astrocytes in a population that express NOS-2. Nitric Oxide 61-73 interferon gamma Homo sapiens 144-152 19099972-12 2008 IFN-gamma further increased PBMNC CD40 expressions in all subjects after culturing for 24 h and fluvastatin equally inhibited IFN-gamma induced PBMNC CD40 expression from various genotypes (CC, CT, TT was 30.3%, 26.3%, 29.3% respectively, all P > 0.05). Fluvastatin 96-107 interferon gamma Homo sapiens 126-135 18581854-1 2008 The renaturation with simultaneous purification of recombinant human interferon-gamma (rhIFN-gamma) expressed as inclusion bodies in Escherichia coli (E. coli) was accomplished by the stationary phase of hydrophobic interaction chromatography (STHIC) with the end group of poly(ethylene glycol) (PEG)(PEG200) packed in a chromatographic column and a chromatographic pie by nonlinear gradient, separately. Polyethylene Glycols 273-294 interferon gamma Homo sapiens 69-85 18581854-1 2008 The renaturation with simultaneous purification of recombinant human interferon-gamma (rhIFN-gamma) expressed as inclusion bodies in Escherichia coli (E. coli) was accomplished by the stationary phase of hydrophobic interaction chromatography (STHIC) with the end group of poly(ethylene glycol) (PEG)(PEG200) packed in a chromatographic column and a chromatographic pie by nonlinear gradient, separately. Polyethylene Glycols 296-299 interferon gamma Homo sapiens 69-85 18581854-1 2008 The renaturation with simultaneous purification of recombinant human interferon-gamma (rhIFN-gamma) expressed as inclusion bodies in Escherichia coli (E. coli) was accomplished by the stationary phase of hydrophobic interaction chromatography (STHIC) with the end group of poly(ethylene glycol) (PEG)(PEG200) packed in a chromatographic column and a chromatographic pie by nonlinear gradient, separately. Polyox WSR-N 60 301-307 interferon gamma Homo sapiens 69-85 18589818-5 2008 The preliminary verification indicates that HBscFv-IFNgamma has the bioactivity of HBscFv and IFNgamma by SDS-PAGE, Western blotting and ELISA. Sodium Dodecyl Sulfate 106-109 interferon gamma Homo sapiens 51-59 18589818-5 2008 The preliminary verification indicates that HBscFv-IFNgamma has the bioactivity of HBscFv and IFNgamma by SDS-PAGE, Western blotting and ELISA. Sodium Dodecyl Sulfate 106-109 interferon gamma Homo sapiens 94-102 17630954-1 2008 Different feeding strategies for the production of human interferon-gamma using an isopropyl beta-D-thiogalactoside-inducible expression system in recombinant Escherichia coli BL21(DE3) (plasmid pET3a-ifngamma) were studied. Isopropyl Thiogalactoside 83-115 interferon gamma Homo sapiens 57-73 18649763-8 2008 The IFN-gamma secretion of the CTLs in the PBMCs of CHB patients with Treg depleted and Treg not depleted was detected by HLA-pentamer and enzyme-linked immunospot assay (Elispot). treg 70-74 interferon gamma Homo sapiens 4-13 18649763-8 2008 The IFN-gamma secretion of the CTLs in the PBMCs of CHB patients with Treg depleted and Treg not depleted was detected by HLA-pentamer and enzyme-linked immunospot assay (Elispot). treg 88-92 interferon gamma Homo sapiens 4-13 18271968-15 2008 CONCLUSION: Elevated proliferation and production of IFN-gamma to metals in hip arthroplasty subjects" lymphocytes indicates that a Th1 (vs. Th2) type response is likely associated with any metal induced reactivity. Metals 66-71 interferon gamma Homo sapiens 53-62 17994120-7 2008 In addition, fludarabine inhibited TNF-alpha-stimulated production of IL-2 and IFN-gamma, which play important roles in the onset of GVHD, in Jurkat cells. fludarabine 13-24 interferon gamma Homo sapiens 79-88 18174256-2 2008 We demonstrate that the IFN-gamma-induced retinoid-inducible gene 1 (RIG1) acts as a transrepressor of p185. Retinoids 42-50 interferon gamma Homo sapiens 24-33 18181098-8 2008 IFN-gamma pretreatment enhanced sensitivity to PS-341 in 50% of the tumor cell lines, potentially related to the induction of immunoproteasomes. Bortezomib 47-53 interferon gamma Homo sapiens 0-9 18048764-8 2008 Thus, the cytokines IL-1beta and interferon-gamma, putative mediators of beta-cell loss in type 1 diabetes, induce severe ER stress through, respectively, NO-mediated depletion of ER calcium and inhibition of ER chaperones, thus hampering beta-cell defenses and amplifying the proapoptotic pathways. Calcium 183-190 interferon gamma Homo sapiens 33-49 17655740-7 2008 The Caco2 SM-induced tolerogenic phenotype is also seen in DC priming of naive T cells with elevated levels of transforming growth factor-beta (TGF-beta) and markedly reduced levels of bacteria-induced interferon-gamma production. caco2 sm 4-12 interferon gamma Homo sapiens 202-218 17719815-7 2008 Further analyses revealed that IGFBP-3, but not IGFBP-1, could significantly enhance the weak tyrosine phosphorylation of STAT1 induced by IFN-gamma (20 U/ml) alone. Tyrosine 94-102 interferon gamma Homo sapiens 139-148 17719815-8 2008 The IGFBP-3-promoted apoptosis in the presence of IFN-gamma could also be abrogated by blockade of the mTOR pathway with its pharmacological inhibitors, LY294002 or rapamycin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 153-161 interferon gamma Homo sapiens 50-59 17719815-8 2008 The IGFBP-3-promoted apoptosis in the presence of IFN-gamma could also be abrogated by blockade of the mTOR pathway with its pharmacological inhibitors, LY294002 or rapamycin. Sirolimus 165-174 interferon gamma Homo sapiens 50-59 17662042-12 2008 IFN-gamma-induced inhibition of chemokine expression and release was NO dependent, as treatment with the NOS inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME) reduced the IFN-gamma inhibitory effect on IL-8 and CCL1 mRNA expression. NG-Nitroarginine Methyl Ester 155-161 interferon gamma Homo sapiens 175-184 17662042-0 2008 Interferon-gamma regulates chemokine expression and release in the human mast cell line HMC1: role of nitric oxide. Nitric Oxide 102-114 interferon gamma Homo sapiens 0-16 17662042-3 2008 IFN-gamma modulates rodent MC responsiveness via production of nitric oxide (NO), although the effects in human MC populations is unknown. Nitric Oxide 63-75 interferon gamma Homo sapiens 0-9 17662042-9 2008 IFN-gamma inhibited phorbol 12-myristate 13-acetate (PMA)-induced release of IL-8 and CCL1 (by 47 and 38%). Tetradecanoylphorbol Acetate 20-51 interferon gamma Homo sapiens 0-9 17894798-7 2008 Moreover, T-cell cytokine production in the absence of 5-LO-derived leukotrienes results in increased IL-4 production and decreased interferon (IFN)-gamma production. derived 60-67 interferon gamma Homo sapiens 132-154 17662042-9 2008 IFN-gamma inhibited phorbol 12-myristate 13-acetate (PMA)-induced release of IL-8 and CCL1 (by 47 and 38%). Tetradecanoylphorbol Acetate 53-56 interferon gamma Homo sapiens 0-9 17894798-7 2008 Moreover, T-cell cytokine production in the absence of 5-LO-derived leukotrienes results in increased IL-4 production and decreased interferon (IFN)-gamma production. Leukotrienes 68-80 interferon gamma Homo sapiens 132-154 17662042-12 2008 IFN-gamma-induced inhibition of chemokine expression and release was NO dependent, as treatment with the NOS inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME) reduced the IFN-gamma inhibitory effect on IL-8 and CCL1 mRNA expression. NG-Nitroarginine Methyl Ester 119-153 interferon gamma Homo sapiens 0-9 17662042-12 2008 IFN-gamma-induced inhibition of chemokine expression and release was NO dependent, as treatment with the NOS inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME) reduced the IFN-gamma inhibitory effect on IL-8 and CCL1 mRNA expression. NG-Nitroarginine Methyl Ester 119-153 interferon gamma Homo sapiens 175-184 17662042-12 2008 IFN-gamma-induced inhibition of chemokine expression and release was NO dependent, as treatment with the NOS inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME) reduced the IFN-gamma inhibitory effect on IL-8 and CCL1 mRNA expression. NG-Nitroarginine Methyl Ester 155-161 interferon gamma Homo sapiens 0-9 18209043-6 2008 In this study on 11 healthy volunteers, we found that a newly developed protocol based on cyanoacrylate skin surface stripping induced a significant increase in IFN-gamma-producing T cells specific for influenza vaccine by ELISPOT assays. Cyanoacrylates 90-103 interferon gamma Homo sapiens 161-170 18209080-9 2008 The proline/serine/threonine region of CIITA showed significant decrease in phosphorylation at high IFN-gamma levels. Proline 4-11 interferon gamma Homo sapiens 100-109 17914444-4 2008 Biologically, relevant doses of Ze-NO induce a dermal CD4-positive T-cell infiltrate and IFN-gamma secretion. ze-no 32-37 interferon gamma Homo sapiens 89-98 18209080-9 2008 The proline/serine/threonine region of CIITA showed significant decrease in phosphorylation at high IFN-gamma levels. Serine 12-18 interferon gamma Homo sapiens 100-109 18209080-9 2008 The proline/serine/threonine region of CIITA showed significant decrease in phosphorylation at high IFN-gamma levels. Threonine 19-28 interferon gamma Homo sapiens 100-109 18476628-3 2008 MTT colorimetric assay was used to evaluate the effect of interferon-gamma on Hep-2 cell proliferation after incubation with interferon-gamma. monooxyethylene trimethylolpropane tristearate 0-3 interferon gamma Homo sapiens 58-74 17962517-2 2008 In BEAS-2B human airway epithelial cells, taprostene, a selective IP-receptor agonist, suppressed interferon-gamma-induced CXCL9 and CXCL10 release in a concentration-dependent manner. taprostene 42-52 interferon gamma Homo sapiens 98-114 18476628-3 2008 MTT colorimetric assay was used to evaluate the effect of interferon-gamma on Hep-2 cell proliferation after incubation with interferon-gamma. monooxyethylene trimethylolpropane tristearate 0-3 interferon gamma Homo sapiens 125-141 18178816-0 2008 Prostaglandin D2 inhibits the production of IFN-gamma by invariant NK T cells: consequences in the control of B16 melanoma. Prostaglandin D2 0-16 interferon gamma Homo sapiens 44-53 17662038-4 2008 There was a significant increase in the percentage of CD4+ and CD8+ T cells producing IL-4 and IL-13 and decrease in the percentage of CD4+ and CD8+ T cells producing IFN-gamma upon in vitro stimulation with phorbol 12-myristate 13-acetate and ionomycin in children with AD compared to healthy ones. Tetradecanoylphorbol Acetate 208-239 interferon gamma Homo sapiens 167-176 18178816-5 2008 We show that PGD2 dramatically reduced the production of IFN-gamma, but not IL-4, by iNKT cells in response to the superagonist alpha-galactosylceramide (alpha-GalCer) both in vitro and in vivo. Prostaglandin D2 13-17 interferon gamma Homo sapiens 57-66 18178867-7 2008 Stimulation of ASMC with TNF-alpha and, to a lesser extent, IFN-gamma resulted in an up-regulation of CCR1 expression, which was totally suppressed by both dexamethasone or mithramycin. asmc 15-19 interferon gamma Homo sapiens 60-69 18178816-5 2008 We show that PGD2 dramatically reduced the production of IFN-gamma, but not IL-4, by iNKT cells in response to the superagonist alpha-galactosylceramide (alpha-GalCer) both in vitro and in vivo. alpha-galactosylceramide 128-152 interferon gamma Homo sapiens 57-66 18178867-7 2008 Stimulation of ASMC with TNF-alpha and, to a lesser extent, IFN-gamma resulted in an up-regulation of CCR1 expression, which was totally suppressed by both dexamethasone or mithramycin. Dexamethasone 156-169 interferon gamma Homo sapiens 60-69 18178867-7 2008 Stimulation of ASMC with TNF-alpha and, to a lesser extent, IFN-gamma resulted in an up-regulation of CCR1 expression, which was totally suppressed by both dexamethasone or mithramycin. Plicamycin 173-184 interferon gamma Homo sapiens 60-69 18178816-7 2008 We also report that PGD2 and BW245C (a selective DP1 agonist) reduce the protective effects of alpha-GalCer in B16F10-induced melanoma metastasis, an effect that depends on IFN-gamma production by iNKT cells. Prostaglandin D2 20-24 interferon gamma Homo sapiens 173-182 18178816-7 2008 We also report that PGD2 and BW245C (a selective DP1 agonist) reduce the protective effects of alpha-GalCer in B16F10-induced melanoma metastasis, an effect that depends on IFN-gamma production by iNKT cells. BW 245C 29-35 interferon gamma Homo sapiens 173-182 18184463-0 2008 [Regulating human interferon-gamma gene expression in marrow stromal cells in mice by Tet-off system]. tetramethylenedisulfotetramine 86-89 interferon gamma Homo sapiens 18-34 18505179-6 2008 RESULTS: We demonstrated using in vitro models of immune activation that the production of interferon-gamma was specifically induced by abacavir treatment in PBMCs obtained from hypersensitive patients carrying the HLA-B*5701 allele (median 123.86 compared with -30.83 for tolerant controls, P=0.001). abacavir 136-144 interferon gamma Homo sapiens 91-107 18184463-1 2008 BACKGROUND & OBJECTIVE: We have constructed plasmid "pTre-IFN-gamma" and proved that the Tet-off system could regulate the expression of human interferon-gamma (IFN-gamma) gene in murine marrow stromal cells in vitro. Adenosine Monophosphate 12-15 interferon gamma Homo sapiens 62-71 18184463-1 2008 BACKGROUND & OBJECTIVE: We have constructed plasmid "pTre-IFN-gamma" and proved that the Tet-off system could regulate the expression of human interferon-gamma (IFN-gamma) gene in murine marrow stromal cells in vitro. Adenosine Monophosphate 12-15 interferon gamma Homo sapiens 147-163 18184463-1 2008 BACKGROUND & OBJECTIVE: We have constructed plasmid "pTre-IFN-gamma" and proved that the Tet-off system could regulate the expression of human interferon-gamma (IFN-gamma) gene in murine marrow stromal cells in vitro. tetramethylenedisulfotetramine 93-96 interferon gamma Homo sapiens 62-71 18184463-1 2008 BACKGROUND & OBJECTIVE: We have constructed plasmid "pTre-IFN-gamma" and proved that the Tet-off system could regulate the expression of human interferon-gamma (IFN-gamma) gene in murine marrow stromal cells in vitro. tetramethylenedisulfotetramine 93-96 interferon gamma Homo sapiens 147-163 18184463-1 2008 BACKGROUND & OBJECTIVE: We have constructed plasmid "pTre-IFN-gamma" and proved that the Tet-off system could regulate the expression of human interferon-gamma (IFN-gamma) gene in murine marrow stromal cells in vitro. tetramethylenedisulfotetramine 93-96 interferon gamma Homo sapiens 165-174 18184463-2 2008 This study was to investigate the regulatory reversibility of Tet-off system and its effect on the expression of human IFN-gamma gene in murine marrow stromal cells in mice. tetramethylenedisulfotetramine 62-65 interferon gamma Homo sapiens 119-128 18184463-13 2008 CONCLUSION: In mice, Tet-off system could rapidly, efficiently and reversibly regulate the expression of human IFN-gamma gene in marrow stromal cells in vitro and in vivo. tetramethylenedisulfotetramine 21-24 interferon gamma Homo sapiens 111-120 17986299-0 2008 The lipophilic hapten parthenolide induces interferon-gamma and interleukin-13 production by peripheral blood-derived CD8+ T cells from contact allergic subjects in vitro. parthenolide 22-34 interferon gamma Homo sapiens 43-59 17997512-6 2008 Poly( dl-lactic-coglycolic acid) nanoparticles conjugated with polyethylene glycol and cLABL demonstrated rapid binding to HUVEC with upregulated ICAM-1, which was induced by treating cells with the proinflammatory cytokine, interferon-gamma. Polyglactin 910 0-32 interferon gamma Homo sapiens 225-241 17997512-6 2008 Poly( dl-lactic-coglycolic acid) nanoparticles conjugated with polyethylene glycol and cLABL demonstrated rapid binding to HUVEC with upregulated ICAM-1, which was induced by treating cells with the proinflammatory cytokine, interferon-gamma. Polyethylene Glycols 63-82 interferon gamma Homo sapiens 225-241 17997512-6 2008 Poly( dl-lactic-coglycolic acid) nanoparticles conjugated with polyethylene glycol and cLABL demonstrated rapid binding to HUVEC with upregulated ICAM-1, which was induced by treating cells with the proinflammatory cytokine, interferon-gamma. clabl 87-92 interferon gamma Homo sapiens 225-241 17986299-5 2008 RESULTS: The allergic group, but not the control group, responded to parthenolide with increased numbers of cells producing interferon (IFN)-gamma, interleukin (IL)-2, IL-4, IL-5 (P < 0.05 for all) and IL-13 (P < 0.01). parthenolide 69-81 interferon gamma Homo sapiens 124-146 17986299-8 2008 In contrast to the CD4+ T cell-mediated peripheral reactivity induced by nickel, cell depletion experiments identified the parthenolide-reactive IFN-gamma- and IL-13-producing cells as CD8+ T cells. parthenolide 123-135 interferon gamma Homo sapiens 145-154 17964857-5 2008 We demonstrated for the first time that treatment with TNF-alpha and IFN-gamma changed lipid composition and fatty acyl substitutions of phospholipids in membrane microdomains of TJs. Phospholipids 137-150 interferon gamma Homo sapiens 69-78 18005262-5 2008 Levamisole-treated human DC also enhanced T cell activation towards type 1 T helper immune response by inducing interferon-gamma secretion. Levamisole 0-10 interferon gamma Homo sapiens 112-128 18006589-16 2008 At the cellular level, soluble heparan sulfate enhanced the secretion of IFNgamma by NK-92 natural killer cells activated with anti-NKp30 monoclonal antibody. Heparitin Sulfate 31-46 interferon gamma Homo sapiens 73-81 18061950-11 2008 The use of PPD to stimulate CD4+IFN-gamma+ cells in the lung in active TB leads to >3-12-fold greater responses than seen with CFP-10 or ESAT-6, and any interference from BCG vaccination is absent. Terbium 71-73 interferon gamma Homo sapiens 32-41 18214799-4 2008 Isolated peripheral blood mononuclear cells from women with endometriosis and uterine leiomyoma were stimulated with PMA and ionomycin or with LPS to induce intracellular synthesis of TNF-alpha, IFN-gamma, and IL-8 in subpopulations of CD3+ cells and TNF-alpha, IL-6, IL-10, MCP-1, and IL-8 in CD14+ cells. Tetradecanoylphorbol Acetate 117-120 interferon gamma Homo sapiens 195-204 20306679-5 2008 Bulk cultures generated by Aspf-CFA-BLCL after at least two primings with Aspf-CFA-DC showed approximately the same Aspf-specific lytic activity, effector cell phenotype, expansion level and percentage expression of IFN-gamma, CD69 and CD107a without any significant differences (p > 0.05) as standard bulk cultures generated by only Aspf-CFA-DC. aspf-cfa 27-35 interferon gamma Homo sapiens 216-225 18406365-5 2008 We have demonstrated expression of TLR3 in Vgamma9Vdelta2 T cells and striking costimulatory effects of the ligand polyinosinic-polycytidylic acid (polyI:C) on TCR-stimulated IFN-gamma production. Poly I-C 115-146 interferon gamma Homo sapiens 175-184 18389438-6 2008 Lycopene induced a dose-dependent increase in IL1beta, and TNFalpha production and a decrease in IL-2, IL-10 and IFNgamma secretion, whereas that of IL-6 and IL-1ra was not affected. Lycopene 0-8 interferon gamma Homo sapiens 113-121 18406365-5 2008 We have demonstrated expression of TLR3 in Vgamma9Vdelta2 T cells and striking costimulatory effects of the ligand polyinosinic-polycytidylic acid (polyI:C) on TCR-stimulated IFN-gamma production. Poly I-C 148-155 interferon gamma Homo sapiens 175-184 18472047-7 2008 Results showed that ATP decreased the rise in concentrations of TNF-alpha, interferon-gamma (IFN-gamma) and IL-1beta, but increased concentrations of IL-8 and IL-10. Adenosine Triphosphate 20-23 interferon gamma Homo sapiens 75-91 18472047-7 2008 Results showed that ATP decreased the rise in concentrations of TNF-alpha, interferon-gamma (IFN-gamma) and IL-1beta, but increased concentrations of IL-8 and IL-10. Adenosine Triphosphate 20-23 interferon gamma Homo sapiens 93-102 18389675-6 2008 Results showed the reduction of plaque and gingival indices, and IL-2 and IFN-gamma level with Chlorhexidine, Essential oil, and Povidone iodine, which were found to be statistically significant. Chlorhexidine 95-108 interferon gamma Homo sapiens 74-83 18389675-6 2008 Results showed the reduction of plaque and gingival indices, and IL-2 and IFN-gamma level with Chlorhexidine, Essential oil, and Povidone iodine, which were found to be statistically significant. Oils, Volatile 110-123 interferon gamma Homo sapiens 74-83 18389675-8 2008 Therefore, Chlorhexidine, Essential oil, and Povidone iodine mouthwashes can be used as an adjunct to oral prophylaxis in reducing pro-inflammatory cytokines, IL-2 and IFN-gamma in patients with chronic gingivitis. Chlorhexidine 11-24 interferon gamma Homo sapiens 168-177 18389675-8 2008 Therefore, Chlorhexidine, Essential oil, and Povidone iodine mouthwashes can be used as an adjunct to oral prophylaxis in reducing pro-inflammatory cytokines, IL-2 and IFN-gamma in patients with chronic gingivitis. Oils, Volatile 26-39 interferon gamma Homo sapiens 168-177 18389675-8 2008 Therefore, Chlorhexidine, Essential oil, and Povidone iodine mouthwashes can be used as an adjunct to oral prophylaxis in reducing pro-inflammatory cytokines, IL-2 and IFN-gamma in patients with chronic gingivitis. Povidone-Iodine 45-60 interferon gamma Homo sapiens 168-177 17976731-8 2008 Expression of mRNAs for IL-1 beta, IFN-gamma, and IL-10 decreased at day 2-7 of doxycycline treatment. Doxycycline 80-91 interferon gamma Homo sapiens 35-44 18188096-2 2008 Antigen-stimulated human T lymphocytes produce significantly lower quantities of interferon-gamma and tumor necrosis factor-alpha after stimulation in vitro in the presence of DA-DKP. aspartyl-alanyl-diketopiperazine 176-182 interferon gamma Homo sapiens 81-129 18679047-4 2008 Melatonin not only stimulates the production of natural killer cells, monocytes and leukocytes, but also alters the balance of T helper (Th)-1 and Th-2 cells mainly towards Th-1 responses and increases the production of relevant cytokines such as interleukin (IL)-2, IL-6, IL-12 and interferon-gamma. Melatonin 0-9 interferon gamma Homo sapiens 283-299 17906116-7 2008 Chronic alcohol consumption increased IFN-gamma-producing NK cells and GATA-3 expression in splenic NK cells. Alcohols 8-15 interferon gamma Homo sapiens 38-47 17934698-1 2008 Culturing hepatocytes with a combination of LPS, TNF-alpha, IL-1beta and IFN-gamma resulted in an inhibition of glucose output from glycogen and prevented the repletion of glycogen in freshly cultured cells. Glucose 112-119 interferon gamma Homo sapiens 73-82 17934698-1 2008 Culturing hepatocytes with a combination of LPS, TNF-alpha, IL-1beta and IFN-gamma resulted in an inhibition of glucose output from glycogen and prevented the repletion of glycogen in freshly cultured cells. Glycogen 132-140 interferon gamma Homo sapiens 73-82 17934698-1 2008 Culturing hepatocytes with a combination of LPS, TNF-alpha, IL-1beta and IFN-gamma resulted in an inhibition of glucose output from glycogen and prevented the repletion of glycogen in freshly cultured cells. Glycogen 172-180 interferon gamma Homo sapiens 73-82 17716796-0 2008 The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma. perospirone 39-50 interferon gamma Homo sapiens 115-131 18637422-6 2008 Blood sample was obtained from patients and examined for the expression of IFN-gamma and TNF-alpha by intracellular staining procedure after stimulation with PMA/ionomycin and allergen. Tetradecanoylphorbol Acetate 158-161 interferon gamma Homo sapiens 75-84 18637422-6 2008 Blood sample was obtained from patients and examined for the expression of IFN-gamma and TNF-alpha by intracellular staining procedure after stimulation with PMA/ionomycin and allergen. Ionomycin 162-171 interferon gamma Homo sapiens 75-84 18637422-7 2008 RESULTS: Negative correlation was found between expression of IFN-gamma and TNF-alpha after PMA/ionomycin stimulation and allergen stimulation (p > 0,05). Ionomycin 96-105 interferon gamma Homo sapiens 62-71 18941518-4 2008 However, whether mycolactone diffuses from infected tissues and suppresses IFN-gamma responses in BU patients remains unclear. mycolactone 17-28 interferon gamma Homo sapiens 75-84 17716796-0 2008 The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma. ziprasidone 52-63 interferon gamma Homo sapiens 115-131 17716796-0 2008 The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma. Quetiapine Fumarate 68-78 interferon gamma Homo sapiens 115-131 17936881-3 2008 MATERIALS AND METHODS: To achieve elevated sPLA(2)-IIA production as occurring during inflammation, HASMC were stimulated with interferon-gamma (IFN-gamma) alone and in combination with other inductors, thus modeling the strong sPLA(2)-IIA elevation by inflammation. hasmc 100-105 interferon gamma Homo sapiens 127-143 19065267-3 2008 IFN-gamma-inducible protein 10 (IP-10/CXCL10) has recently been evaluated as a marker for active TB in adults with promising results. Terbium 97-99 interferon gamma Homo sapiens 0-9 18584538-1 2008 Neopterin is secreted by activated monocytes/macrophages upon stimulation with interferon-gamma. Neopterin 0-9 interferon gamma Homo sapiens 79-95 18590109-7 2008 CONCLUSION: One of the causes of low count of TNFalpha, IFNgamma and IL-4 producing T-lymphocytes in peripheral blood is migration of relevant TC-subpopulations to the affected joints. Technetium 143-145 interferon gamma Homo sapiens 56-64 17936881-3 2008 MATERIALS AND METHODS: To achieve elevated sPLA(2)-IIA production as occurring during inflammation, HASMC were stimulated with interferon-gamma (IFN-gamma) alone and in combination with other inductors, thus modeling the strong sPLA(2)-IIA elevation by inflammation. hasmc 100-105 interferon gamma Homo sapiens 145-154 18346319-8 2008 In vitro culture with antigen presenting cells, the levels of IFNgamma and TNFalpha secreted by LP-CD(4)(+) T cells from the inflammatory colonic tissue were significantly higher than those from the non-inflammatory colonic tissue (both P < 0.01). lp-cd 96-101 interferon gamma Homo sapiens 62-70 18346319-9 2008 The levels of IFNgamma and TNFalpha secreted by LP-CD(4)(+) T cells from the inflammatory colonic tissue were further increased by anti-OX40 MoAb stimulation, but suppressed significantly by adding anti-OX40L MoAb (compared with non stimulation, P < 0.01, respectively). lp-cd 48-53 interferon gamma Homo sapiens 14-22 18054415-6 2007 Intracellular expression of IFN-gamma and IL-4 by CD3+CD8(-) (Th1 and Th2, respectively) and CD3+CD8+ (Tc1 and Tc2, respectively) was estimated by flow cytometry in peripheral blood cells after stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 211-214 interferon gamma Homo sapiens 28-37 18054415-6 2007 Intracellular expression of IFN-gamma and IL-4 by CD3+CD8(-) (Th1 and Th2, respectively) and CD3+CD8+ (Tc1 and Tc2, respectively) was estimated by flow cytometry in peripheral blood cells after stimulation with PMA and ionomycin. Ionomycin 219-228 interferon gamma Homo sapiens 28-37 17996686-7 2007 RESULTS: In T cells from CD patients, 1,25-dihydroxyvitamin D3 and DEX increased IL-10 production from a median of 0.08 ng/ml to 0.2 ng/ml (p<0.01) and downregulated IFN-gamma production from 8.3 ng/ml to 3.1 ng/ml (p<0.01). Calcitriol 38-62 interferon gamma Homo sapiens 169-178 17996686-7 2007 RESULTS: In T cells from CD patients, 1,25-dihydroxyvitamin D3 and DEX increased IL-10 production from a median of 0.08 ng/ml to 0.2 ng/ml (p<0.01) and downregulated IFN-gamma production from 8.3 ng/ml to 3.1 ng/ml (p<0.01). Dexamethasone 67-70 interferon gamma Homo sapiens 169-178 17996686-12 2007 CONCLUSION: We found that 1,25-dihydroxyvitamin D3 with and without DEX stimulation increased IL-10 and reduced IFN-gamma production. Calcitriol 26-50 interferon gamma Homo sapiens 112-121 17996686-12 2007 CONCLUSION: We found that 1,25-dihydroxyvitamin D3 with and without DEX stimulation increased IL-10 and reduced IFN-gamma production. Dexamethasone 68-71 interferon gamma Homo sapiens 112-121 18064390-6 2007 The results showed that exogenous ghrelin could significantly inhibit TNF-alpha/IFN-gamma induced CD40 expression in HUVEC cells in a concentration-dependent manner. Ghrelin 34-41 interferon gamma Homo sapiens 80-89 17928537-4 2007 Histamine enhanced TNF-alpha- or IFN-gamma-induced hBD-2 secretion and mRNA expression. Histamine 0-9 interferon gamma Homo sapiens 33-42 17928537-12 2007 These results suggest that histamine stimulates H1 receptor and potentiates TNF-alpha- or IFN-gamma-induced hBD-2 production dependent on NF-kappaB, AP-1, or STAT1 in human keratinocytes. Histamine 27-36 interferon gamma Homo sapiens 90-99 17928537-5 2007 Histamine alone enhanced transcriptional activities of NF-kappaB and activator protein-1 (AP-1) and potentiated TNF-alpha-induced NF-kappaB and AP-1 activities or IFN-gamma-induced NF-kappaB and STAT1 activities. Histamine 0-9 interferon gamma Homo sapiens 163-172 17928537-6 2007 Antisense oligonucleotides against NF-kappaB components p50 and p65, AP-1 components c-Jun and c-Fos, or H1 antagonist pyrilamine suppressed hBD-2 production induced by histamine plus TNF-alpha or IFN-gamma. Oligonucleotides 10-26 interferon gamma Homo sapiens 197-206 17928537-6 2007 Antisense oligonucleotides against NF-kappaB components p50 and p65, AP-1 components c-Jun and c-Fos, or H1 antagonist pyrilamine suppressed hBD-2 production induced by histamine plus TNF-alpha or IFN-gamma. Histamine 169-178 interferon gamma Homo sapiens 197-206 17928537-7 2007 Antisense oligonucleotide against STAT1 only suppressed hBD-2 production induced by histamine plus IFN-gamma. Oligonucleotides 10-25 interferon gamma Homo sapiens 99-108 17928537-8 2007 Histamine induced serine phosphorylation of inhibitory NF-kappaBalpha (IkappaBalpha) alone or together with TNF-alpha or IFN-gamma. Histamine 0-9 interferon gamma Homo sapiens 121-130 17928537-8 2007 Histamine induced serine phosphorylation of inhibitory NF-kappaBalpha (IkappaBalpha) alone or together with TNF-alpha or IFN-gamma. Serine 18-24 interferon gamma Homo sapiens 121-130 17928537-10 2007 Histamine induced serine phosphorylation of STAT1 alone or together with IFN-gamma, whereas it did not further enhance IFN-gamma-induced tyrosine phosphorylation of STAT1. Histamine 0-9 interferon gamma Homo sapiens 73-82 18077563-6 2007 The effect of IFN-gamma on iNOS might be mediated by kynurenine derivatives of tryptophan because (1) IFN-gamma stimulates the rate-determining enzyme of the Try-kynurenine pathway, indoleamine-2,3-dioxygenase (IDO) and (2) some kynurenines (e.g., quinolinic and picolinic acids) can stimulate iNOS. Kynurenine 53-63 interferon gamma Homo sapiens 14-23 18077563-6 2007 The effect of IFN-gamma on iNOS might be mediated by kynurenine derivatives of tryptophan because (1) IFN-gamma stimulates the rate-determining enzyme of the Try-kynurenine pathway, indoleamine-2,3-dioxygenase (IDO) and (2) some kynurenines (e.g., quinolinic and picolinic acids) can stimulate iNOS. Kynurenine 162-172 interferon gamma Homo sapiens 14-23 18077563-6 2007 The effect of IFN-gamma on iNOS might be mediated by kynurenine derivatives of tryptophan because (1) IFN-gamma stimulates the rate-determining enzyme of the Try-kynurenine pathway, indoleamine-2,3-dioxygenase (IDO) and (2) some kynurenines (e.g., quinolinic and picolinic acids) can stimulate iNOS. Kynurenine 53-63 interferon gamma Homo sapiens 102-111 18077563-6 2007 The effect of IFN-gamma on iNOS might be mediated by kynurenine derivatives of tryptophan because (1) IFN-gamma stimulates the rate-determining enzyme of the Try-kynurenine pathway, indoleamine-2,3-dioxygenase (IDO) and (2) some kynurenines (e.g., quinolinic and picolinic acids) can stimulate iNOS. Kynurenine 162-172 interferon gamma Homo sapiens 102-111 18077563-6 2007 The effect of IFN-gamma on iNOS might be mediated by kynurenine derivatives of tryptophan because (1) IFN-gamma stimulates the rate-determining enzyme of the Try-kynurenine pathway, indoleamine-2,3-dioxygenase (IDO) and (2) some kynurenines (e.g., quinolinic and picolinic acids) can stimulate iNOS. Kynurenine 229-240 interferon gamma Homo sapiens 14-23 18077563-6 2007 The effect of IFN-gamma on iNOS might be mediated by kynurenine derivatives of tryptophan because (1) IFN-gamma stimulates the rate-determining enzyme of the Try-kynurenine pathway, indoleamine-2,3-dioxygenase (IDO) and (2) some kynurenines (e.g., quinolinic and picolinic acids) can stimulate iNOS. Tryptophan 79-89 interferon gamma Homo sapiens 14-23 18077563-6 2007 The effect of IFN-gamma on iNOS might be mediated by kynurenine derivatives of tryptophan because (1) IFN-gamma stimulates the rate-determining enzyme of the Try-kynurenine pathway, indoleamine-2,3-dioxygenase (IDO) and (2) some kynurenines (e.g., quinolinic and picolinic acids) can stimulate iNOS. Kynurenine 229-240 interferon gamma Homo sapiens 102-111 18077563-6 2007 The effect of IFN-gamma on iNOS might be mediated by kynurenine derivatives of tryptophan because (1) IFN-gamma stimulates the rate-determining enzyme of the Try-kynurenine pathway, indoleamine-2,3-dioxygenase (IDO) and (2) some kynurenines (e.g., quinolinic and picolinic acids) can stimulate iNOS. Tryptophan 79-89 interferon gamma Homo sapiens 102-111 18077563-6 2007 The effect of IFN-gamma on iNOS might be mediated by kynurenine derivatives of tryptophan because (1) IFN-gamma stimulates the rate-determining enzyme of the Try-kynurenine pathway, indoleamine-2,3-dioxygenase (IDO) and (2) some kynurenines (e.g., quinolinic and picolinic acids) can stimulate iNOS. quinolinic 248-258 interferon gamma Homo sapiens 14-23 17764466-8 2007 The use of nuclear factor-kappa B (NFkappaB) inhibitors, diferuloylmethane (curcumin) and SN50, abrogated bacterial infiltration of both untreated and interferon-gamma-treated cells. Curcumin 57-74 interferon gamma Homo sapiens 151-167 18077563-6 2007 The effect of IFN-gamma on iNOS might be mediated by kynurenine derivatives of tryptophan because (1) IFN-gamma stimulates the rate-determining enzyme of the Try-kynurenine pathway, indoleamine-2,3-dioxygenase (IDO) and (2) some kynurenines (e.g., quinolinic and picolinic acids) can stimulate iNOS. quinolinic 248-258 interferon gamma Homo sapiens 102-111 18077563-6 2007 The effect of IFN-gamma on iNOS might be mediated by kynurenine derivatives of tryptophan because (1) IFN-gamma stimulates the rate-determining enzyme of the Try-kynurenine pathway, indoleamine-2,3-dioxygenase (IDO) and (2) some kynurenines (e.g., quinolinic and picolinic acids) can stimulate iNOS. Picolinic Acids 263-278 interferon gamma Homo sapiens 14-23 18077563-6 2007 The effect of IFN-gamma on iNOS might be mediated by kynurenine derivatives of tryptophan because (1) IFN-gamma stimulates the rate-determining enzyme of the Try-kynurenine pathway, indoleamine-2,3-dioxygenase (IDO) and (2) some kynurenines (e.g., quinolinic and picolinic acids) can stimulate iNOS. Picolinic Acids 263-278 interferon gamma Homo sapiens 102-111 18077563-7 2007 IFN-gamma production is controlled by (IFN-gamma) + 874(T/A) genotypes, suggesting the association of a high promoter T allele with the high rate of IFN-gamma production and, consequently, with activated IDO and enhanced production of kynurenines. Kynurenine 235-246 interferon gamma Homo sapiens 0-9 18077563-7 2007 IFN-gamma production is controlled by (IFN-gamma) + 874(T/A) genotypes, suggesting the association of a high promoter T allele with the high rate of IFN-gamma production and, consequently, with activated IDO and enhanced production of kynurenines. Kynurenine 235-246 interferon gamma Homo sapiens 39-48 18077563-7 2007 IFN-gamma production is controlled by (IFN-gamma) + 874(T/A) genotypes, suggesting the association of a high promoter T allele with the high rate of IFN-gamma production and, consequently, with activated IDO and enhanced production of kynurenines. Kynurenine 235-246 interferon gamma Homo sapiens 39-48 18077563-11 2007 The IFN-gamma-IDO-iNOS hypothesis of VCI suggests new ways of preventing (identifying population at risk by analysis of IFN-gamma and TNF-alpha genetic polymorphism) and treating VCI (using IDO inhibitors and melatonin and bupropion [Wellbutrin] as agents suppressing IFN-gamma and TNF-alpha production). Melatonin 209-218 interferon gamma Homo sapiens 4-13 18077563-11 2007 The IFN-gamma-IDO-iNOS hypothesis of VCI suggests new ways of preventing (identifying population at risk by analysis of IFN-gamma and TNF-alpha genetic polymorphism) and treating VCI (using IDO inhibitors and melatonin and bupropion [Wellbutrin] as agents suppressing IFN-gamma and TNF-alpha production). Bupropion 223-232 interferon gamma Homo sapiens 4-13 18077563-11 2007 The IFN-gamma-IDO-iNOS hypothesis of VCI suggests new ways of preventing (identifying population at risk by analysis of IFN-gamma and TNF-alpha genetic polymorphism) and treating VCI (using IDO inhibitors and melatonin and bupropion [Wellbutrin] as agents suppressing IFN-gamma and TNF-alpha production). Bupropion 234-244 interferon gamma Homo sapiens 4-13 17764466-8 2007 The use of nuclear factor-kappa B (NFkappaB) inhibitors, diferuloylmethane (curcumin) and SN50, abrogated bacterial infiltration of both untreated and interferon-gamma-treated cells. Curcumin 76-84 interferon gamma Homo sapiens 151-167 17827067-4 2007 Here, we report that PBI-1393 enhances IL-2 and IFN-gamma production in human activated T cells by 51% and 46% respectively. PBI-1393 21-29 interferon gamma Homo sapiens 48-57 17827067-7 2007 The enhancement of human T cell proliferation and CTL activation by PBI-1393 demonstrates that this compound potentiates the immune response and in this regard, it could be used as an alternative approach to IL-2 and/or IFN-gamma therapy against cancer. PBI-1393 68-76 interferon gamma Homo sapiens 220-229 18850185-3 2007 Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-gamma-elicited activation of signal transducer and activator of transcription 1 (STAT1). Catechin 50-59 interferon gamma Homo sapiens 166-182 18054563-10 2007 In HT-29 cells, down-regulation of MCT1 mRNA and protein abundance by IFN-gamma and TNF-alpha correlated with a decrease in butyrate uptake and subsequent oxidation. Butyrates 124-132 interferon gamma Homo sapiens 70-79 18850185-3 2007 Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-gamma-elicited activation of signal transducer and activator of transcription 1 (STAT1). epigallocatechin gallate 95-121 interferon gamma Homo sapiens 166-182 18850185-3 2007 Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-gamma-elicited activation of signal transducer and activator of transcription 1 (STAT1). epigallocatechin gallate 123-127 interferon gamma Homo sapiens 166-182 17727629-4 2007 The cytokines interferon-gamma and tumor necrosis factor-alpha also stimulated IL-12 p40 and IL-27 p28 expression by microglia, which was suppressed by fenofibrate. Fenofibrate 152-163 interferon gamma Homo sapiens 14-62 17893127-7 2007 Mechanistically, IFN-gamma controls S. aureus infection via IFN-gamma receptor, most likely through stimulation of intrinsic endothelial antibacterial mechanisms but independent of processes that deprive bacteria of intracellular L-tryptophan or iron. Tryptophan 230-242 interferon gamma Homo sapiens 17-26 17893127-7 2007 Mechanistically, IFN-gamma controls S. aureus infection via IFN-gamma receptor, most likely through stimulation of intrinsic endothelial antibacterial mechanisms but independent of processes that deprive bacteria of intracellular L-tryptophan or iron. Tryptophan 230-242 interferon gamma Homo sapiens 60-69 17893127-7 2007 Mechanistically, IFN-gamma controls S. aureus infection via IFN-gamma receptor, most likely through stimulation of intrinsic endothelial antibacterial mechanisms but independent of processes that deprive bacteria of intracellular L-tryptophan or iron. Iron 246-250 interferon gamma Homo sapiens 17-26 17893127-7 2007 Mechanistically, IFN-gamma controls S. aureus infection via IFN-gamma receptor, most likely through stimulation of intrinsic endothelial antibacterial mechanisms but independent of processes that deprive bacteria of intracellular L-tryptophan or iron. Iron 246-250 interferon gamma Homo sapiens 60-69 18003704-8 2007 In summary, we demonstrate that IFN-gamma and TNF-alpha sensitize primarily apoptosis-resistant ESCs to Fas-mediated cell death. ammonium ferrous sulfate 104-107 interferon gamma Homo sapiens 32-41 18167453-2 2007 COS (0.1-5mg/ ml) suppressed the NO production induced by proinflammatory cytokines (100 U/ml IFN-gamma, 10 ng/ml IL-1alpha, and 25 ng/ml TNF-alpha) in HT-29 cells. carbonyl sulfide 0-3 interferon gamma Homo sapiens 94-103 18184040-2 2007 Here, we demonstrate that nontoxic concentrations of zinc (15 muM), employed as zinc chloride (ZnCl(2)), that are about 2-fold of the readily accessible pool of albumin-bound zinc in the plasma, strongly enhance the potential of interleukin-1beta (IL-1beta) to act as an IFN-gamma-inducing factor on PBMCs. zinc chloride 80-93 interferon gamma Homo sapiens 271-280 18184040-2 2007 Here, we demonstrate that nontoxic concentrations of zinc (15 muM), employed as zinc chloride (ZnCl(2)), that are about 2-fold of the readily accessible pool of albumin-bound zinc in the plasma, strongly enhance the potential of interleukin-1beta (IL-1beta) to act as an IFN-gamma-inducing factor on PBMCs. zncl 95-99 interferon gamma Homo sapiens 271-280 18184040-4 2007 ZnCl(2) also amplified IFN-gamma production under the influence of IL-12 or IL-18, whereas IL-1beta-induced IL-8 expression was not enhanced by the addition of ZnCl(2), indicating that the effect observed on cytokine-induced IFN-gamma is not of a general and unspecific nature. zncl 0-4 interferon gamma Homo sapiens 23-32 18212406-7 2007 Melatonin inhibited the Th1-dependent immune response by suppressing the production of IFN-gamma and IL-12 by cells in the lymph node. Melatonin 0-9 interferon gamma Homo sapiens 87-96 17616812-8 2007 Combination of ATRA and IFN-gamma showed more efficacy than IFN-gamma alone in causing apoptosis that occurred due to increases in Bax:Bcl-2 ratio, mitochondrial release of cytochrome c, and caspase-3 activity. Tretinoin 15-19 interferon gamma Homo sapiens 60-69 17676389-5 2007 Our recent study demonstrated that combination of the chemotherapeutic agent all-trans retinoic acid (ATRA) and the immunotherapeutic agent interferon-gamma (IFN-gamma) could concurrently induce differentiation, apoptotic death, and immune components in two different human glioblastoma cell lines. Tretinoin 87-100 interferon gamma Homo sapiens 158-167 18063923-7 2007 Kynurenine, kynurenic acid, and xanthurenic acid, decreased the IFNgamma/IL-10 production ratio, whereas quinolinic acid increased this ratio. Kynurenine 0-10 interferon gamma Homo sapiens 64-72 18063923-7 2007 Kynurenine, kynurenic acid, and xanthurenic acid, decreased the IFNgamma/IL-10 production ratio, whereas quinolinic acid increased this ratio. Kynurenic Acid 12-26 interferon gamma Homo sapiens 64-72 18063923-7 2007 Kynurenine, kynurenic acid, and xanthurenic acid, decreased the IFNgamma/IL-10 production ratio, whereas quinolinic acid increased this ratio. xanthurenic acid 32-48 interferon gamma Homo sapiens 64-72 18063923-9 2007 It is concluded that kynurenine, kynurenic acid, and xanthurenic acid have anti-inflammatory effects trough a reduction of IFNgamma, whereas quinolinic acid has pro-inflammatory effects in particular via significant decreases in IL-10. Kynurenine 21-31 interferon gamma Homo sapiens 123-131 18063923-9 2007 It is concluded that kynurenine, kynurenic acid, and xanthurenic acid have anti-inflammatory effects trough a reduction of IFNgamma, whereas quinolinic acid has pro-inflammatory effects in particular via significant decreases in IL-10. Kynurenic Acid 33-47 interferon gamma Homo sapiens 123-131 18063923-9 2007 It is concluded that kynurenine, kynurenic acid, and xanthurenic acid have anti-inflammatory effects trough a reduction of IFNgamma, whereas quinolinic acid has pro-inflammatory effects in particular via significant decreases in IL-10. xanthurenic acid 53-69 interferon gamma Homo sapiens 123-131 18063923-10 2007 Following inflammation-induced IDO activation, some TRYCATs, i.e. kynurenine, kynurenic acid, and xanthurenic acid, exert a negative feedback control over IFNgamma production thus downregulating the initial inflammation, whereas an excess of quinolinic acid further aggravates the initial inflammation. Kynurenine 66-76 interferon gamma Homo sapiens 155-163 18063923-10 2007 Following inflammation-induced IDO activation, some TRYCATs, i.e. kynurenine, kynurenic acid, and xanthurenic acid, exert a negative feedback control over IFNgamma production thus downregulating the initial inflammation, whereas an excess of quinolinic acid further aggravates the initial inflammation. Kynurenic Acid 78-92 interferon gamma Homo sapiens 155-163 18063923-10 2007 Following inflammation-induced IDO activation, some TRYCATs, i.e. kynurenine, kynurenic acid, and xanthurenic acid, exert a negative feedback control over IFNgamma production thus downregulating the initial inflammation, whereas an excess of quinolinic acid further aggravates the initial inflammation. xanthurenic acid 98-114 interferon gamma Homo sapiens 155-163 18063923-10 2007 Following inflammation-induced IDO activation, some TRYCATs, i.e. kynurenine, kynurenic acid, and xanthurenic acid, exert a negative feedback control over IFNgamma production thus downregulating the initial inflammation, whereas an excess of quinolinic acid further aggravates the initial inflammation. Quinolinic Acid 242-257 interferon gamma Homo sapiens 155-163 18322603-8 2007 In ganciclovir group, the level of IFN-gamma and TNF-alpha did not change after treatment (t=1.75, 1.16, p greater than 0.05), the level of IL-4 in this group was higher than that before treatment (t= 2.39, p less than 0.05). Ganciclovir 3-14 interferon gamma Homo sapiens 35-44 18078418-11 2007 Interferon-gamma was directly related to dopamine, as well as to the lymphocyte and monocyte count. Dopamine 41-49 interferon gamma Homo sapiens 0-16 17980465-4 2007 Intramuscular injection of BV-G-5m6 with various doses (1 x 10(8), 1 x 10(9), and 1 x 10(10)PFU/mouse) induced the production of PRRSV-specific neutralizing antibodies and gamma interferon (IFN-gamma) under dose-dependent pattern. bv-g-5m6 27-35 interferon gamma Homo sapiens 190-199 18030338-6 2007 Moreover, the acquisition of oncogenic H-RasG12V by natural killer (NK) and T lymphocytes had important biological functions in the adopting lymphocytes: the transferred H-RasG12V induced ERK phosphorylation, increased interferon-gamma and tumor necrosis factor-alpha secretion, enhanced lymphocyte proliferation, and augmented NK-mediated target cell killing. h-rasg12v 39-48 interferon gamma Homo sapiens 219-267 18030338-6 2007 Moreover, the acquisition of oncogenic H-RasG12V by natural killer (NK) and T lymphocytes had important biological functions in the adopting lymphocytes: the transferred H-RasG12V induced ERK phosphorylation, increased interferon-gamma and tumor necrosis factor-alpha secretion, enhanced lymphocyte proliferation, and augmented NK-mediated target cell killing. h-rasg12v 170-179 interferon gamma Homo sapiens 219-267 17986321-18 2007 Finally, in TAC2 cells with tetracycline-induced psoriasin expression, we observed the increased viability of psoriasin-expressing cells after IFN-gamma treatment. Tetracycline 28-40 interferon gamma Homo sapiens 143-152 17822676-3 2007 Immunization with gamma-PGA NPs entrapping Eriss-conjugated antigenic peptides markedly amplified and activated CTLs and interferon-gamma-secreting cells specific for the antigen, whereas no cellular immune responses were detected following vaccination with only one of the systems alone. poly(gamma-glutamic acid) 18-27 interferon gamma Homo sapiens 121-137 18201436-8 2007 Aspirin desensitization differentially affects interferon (IFN) gamma expression. Aspirin 0-7 interferon gamma Homo sapiens 47-69 17978190-5 2007 Furthermore, antigen receptor-primed CD4(+) T cells are resistant to Treg induction because of autocrine production of IFNgamma and/or IL-4, whereas neutralizing IFNgamma and IL-4 not only can potentiate TGF-beta-mediated Foxp3 induction in vitro but can also enhance antigen-specific Foxp3(+) Treg differentiation in vivo. treg 69-73 interferon gamma Homo sapiens 119-127 18201436-10 2007 Aspirin desensitization in an aspirin-sensitive patient with asthma resulted in an increase in IFN-gamma expression by CD4(+) lymphocytes and a decrease in IFN-gamma expression by CD8(+) lymphocytes, the significance of which needs additional investigation. Aspirin 0-7 interferon gamma Homo sapiens 95-104 18201436-10 2007 Aspirin desensitization in an aspirin-sensitive patient with asthma resulted in an increase in IFN-gamma expression by CD4(+) lymphocytes and a decrease in IFN-gamma expression by CD8(+) lymphocytes, the significance of which needs additional investigation. Aspirin 0-7 interferon gamma Homo sapiens 156-165 18201436-10 2007 Aspirin desensitization in an aspirin-sensitive patient with asthma resulted in an increase in IFN-gamma expression by CD4(+) lymphocytes and a decrease in IFN-gamma expression by CD8(+) lymphocytes, the significance of which needs additional investigation. Aspirin 30-37 interferon gamma Homo sapiens 95-104 18201436-10 2007 Aspirin desensitization in an aspirin-sensitive patient with asthma resulted in an increase in IFN-gamma expression by CD4(+) lymphocytes and a decrease in IFN-gamma expression by CD8(+) lymphocytes, the significance of which needs additional investigation. Aspirin 30-37 interferon gamma Homo sapiens 156-165 17870068-11 2007 Culture supernatants from IFN-gamma treated primary and metastatic uveal melanoma cell cultures contained elevated levels of kynurenine. Kynurenine 125-135 interferon gamma Homo sapiens 26-35 17916356-5 2007 Serum levels of interferon (IFN)-gamma, endotoxin (TLR4 ligand), and HCV core protein (TLR2 ligand) were elevated in cHCV patients suggesting potential mechanisms for in vivo monocyte preactivation. chcv 117-121 interferon gamma Homo sapiens 16-38 17916356-7 2007 Furthermore, we found increased levels of MyD88-IRAK1 complexes and nuclear factor (NF)-kappaB activity both in monocytes of cHCV patients and in normal monocytes that lost TLR tolerance after IFN-gamma + LPS pretreatment. chcv 125-129 interferon gamma Homo sapiens 193-202 17916356-8 2007 In vitro differentiation of TLR non-tolerant cHCV monocytes into macrophages restored their capacity to exhibit TLR tolerance to LPS and HCV core protein, and this could be reversed by administration of IFN-gamma. chcv 45-49 interferon gamma Homo sapiens 203-212 17916356-11 2007 CONCLUSIONS: We identified that host-derived factors (IFN-gamma and endotoxin) and viral factors (HCV core protein) act in tandem to induce and maintain monocyte/macrophage activation, thus favoring persistent inflammation in patients with cHCV infection. chcv 240-244 interferon gamma Homo sapiens 54-63 17619126-5 2007 After HD-DXM treatment, IFN-gamma and IL-2 were decreased (P < 0.01), whereas IL-4 and IL-10 were increased (P < 0.05). Dexamethasone 9-12 interferon gamma Homo sapiens 24-33 17870068-12 2007 Addition of the IDO inhibitor 1-methyl dl-tryptophan significantly diminished kynurenine levels in IFN-gamma treated uveal melanoma cell cultures. 1-methyltryptophan 30-52 interferon gamma Homo sapiens 99-108 17870068-12 2007 Addition of the IDO inhibitor 1-methyl dl-tryptophan significantly diminished kynurenine levels in IFN-gamma treated uveal melanoma cell cultures. Kynurenine 78-88 interferon gamma Homo sapiens 99-108 18052729-3 2007 GM-CSF inhibited IFN-alpha-induced and IFN-gamma-induced Stat1 tyrosine phosphorylation in a time-dependent manner. Tyrosine 63-71 interferon gamma Homo sapiens 39-48 17947694-3 2007 Recently, we demonstrated the ability of EPs to favor a Th1 cytokine (IL-2, IFN-gamma) cell response in lymphocytes and to regulate IL-1beta expression in melanoma cells. eps 41-44 interferon gamma Homo sapiens 76-85 17457312-5 2007 Proinflammatory cytokines such as interleukin-2, interferon-gamma, or tumor necrosis factor-alpha activate the tryptophan- and serotonin-degrading enzyme indoleamine 2,3-dioxygenase (IDO). Tryptophan 111-121 interferon gamma Homo sapiens 49-97 17951506-5 2007 Butyrate is a natural histone deacetylase inhibitor as well as a molecule involved with enhanced TGF-beta-induced SMAD3 phosphorylation, increased IFN-gamma-mediated apoptosis, and altered expression of the intestinal muc2 gene that is responsible for mucin synthesis. Butyrates 0-8 interferon gamma Homo sapiens 147-156 17457312-5 2007 Proinflammatory cytokines such as interleukin-2, interferon-gamma, or tumor necrosis factor-alpha activate the tryptophan- and serotonin-degrading enzyme indoleamine 2,3-dioxygenase (IDO). Serotonin 127-136 interferon gamma Homo sapiens 49-97 18001433-3 2007 Furthermore, both cord plasma IL-4/interferon (IFN)-gamma and IL-13/IFN-gamma ratios were significantly positively associated with placental p,p"-DDE concentration. Dichlorodiphenyl Dichloroethylene 141-149 interferon gamma Homo sapiens 68-77 17543418-4 2007 In unstimulated T and NK cells, interferon-gamma (IFN-gamma) production was unaffected by NMDA, whereas interleukin-2 stimulation of IFN-gamma production was significantly suppressed by NMDA. N-Methylaspartate 186-190 interferon gamma Homo sapiens 133-142 17991146-12 2007 CONCLUSIONS: The potent nitric oxide generating cytotoxin STZ is able to impair in vitro NPI beta cell insulin release whereas human cytokines (IL-1 beta, TNFalpha, IFN gamma) do not affect the secretory response nor are they cytotoxic in vitro. Nitric Oxide 24-36 interferon gamma Homo sapiens 165-174 17991146-12 2007 CONCLUSIONS: The potent nitric oxide generating cytotoxin STZ is able to impair in vitro NPI beta cell insulin release whereas human cytokines (IL-1 beta, TNFalpha, IFN gamma) do not affect the secretory response nor are they cytotoxic in vitro. Streptozocin 58-61 interferon gamma Homo sapiens 165-174 17640998-2 2007 Our previous studies have demonstrated that normal primary thyroid epithelial cells are resistant to Fas-mediated apoptosis, but the resistance can be overcome by pretreatment with a combination of interferon-gamma (IFN-gamma) and IL-1beta. ammonium ferrous sulfate 101-104 interferon gamma Homo sapiens 198-214 17940602-7 2007 IFN-gamma and SP concentrations were lower in NPA from infants who required oxygen or mechanical ventilation. Oxygen 76-82 interferon gamma Homo sapiens 0-9 17877375-3 2007 In this study, a heme biosynthesis inhibitor, succinylacetone (SA), was found to inhibit cellular TrpRS activity in IFN-gamma-activated cells without affecting TrpRS protein expression. Heme 17-21 interferon gamma Homo sapiens 116-125 17877375-3 2007 In this study, a heme biosynthesis inhibitor, succinylacetone (SA), was found to inhibit cellular TrpRS activity in IFN-gamma-activated cells without affecting TrpRS protein expression. succinylacetone 46-61 interferon gamma Homo sapiens 116-125 17877375-3 2007 In this study, a heme biosynthesis inhibitor, succinylacetone (SA), was found to inhibit cellular TrpRS activity in IFN-gamma-activated cells without affecting TrpRS protein expression. succinylacetone 63-65 interferon gamma Homo sapiens 116-125 17595227-5 2007 In astrocytes, LPS/IFN-gamma treatment reduced cell viability, increased the number of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling-positive cells and activated caspase-3. deoxyuridine triphosphate 134-138 interferon gamma Homo sapiens 19-28 17640998-2 2007 Our previous studies have demonstrated that normal primary thyroid epithelial cells are resistant to Fas-mediated apoptosis, but the resistance can be overcome by pretreatment with a combination of interferon-gamma (IFN-gamma) and IL-1beta. ammonium ferrous sulfate 101-104 interferon gamma Homo sapiens 216-225 17640998-6 2007 Furthermore, the sensitization of primary thyroid epithelial cells to Fas-mediated apoptosis by IFN-gamma/IL-1beta was significantly blocked by a general caspase inhibitor, z-VAD, or by the combination of two specific individual caspase inhibitors. ammonium ferrous sulfate 70-73 interferon gamma Homo sapiens 96-105 17640998-6 2007 Furthermore, the sensitization of primary thyroid epithelial cells to Fas-mediated apoptosis by IFN-gamma/IL-1beta was significantly blocked by a general caspase inhibitor, z-VAD, or by the combination of two specific individual caspase inhibitors. z-vad 173-178 interferon gamma Homo sapiens 96-105 17640998-7 2007 In addition, our results showed that IFN-gamma/IL-1beta enhance p38 MAPK phosphorylation and that SB 203580, a p38 MAPK inhibitor, can inhibit IFN-gamma/IL-1beta-induced p38 MAPK phosphorylation. SB 203580 98-107 interferon gamma Homo sapiens 143-152 17640998-8 2007 SB 203580 also significantly prevented cytokine-induced iNOS expression and caspase activation and thus blocked Fas-mediated apoptosis of thyroid cells sensitized by IFN-gamma/IL-1beta. SB 203580 0-9 interferon gamma Homo sapiens 166-175 17640998-9 2007 In conclusion, our data suggest that both p38 MAPK and iNOS are involved in IFN-gamma/IL-1beta-induced sensitization of the thyroid cells to Fas-mediated apoptosis via the activation of caspases 3, 7, and 10 and that this pathway may be further activated by BID. ammonium ferrous sulfate 141-144 interferon gamma Homo sapiens 76-85 17765224-7 2007 ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05). Reactive Oxygen Species 101-104 interferon gamma Homo sapiens 141-150 17765224-6 2007 NADPH oxidase inhibitor (diphenylene iodinium) abolished the ROS production induced by IL-1 beta or IFN-gamma, but not by TNF-alpha, whereas 6-aminonicotinamide (6AN), an inhibitor of the hexose monophosphate shunt (HMS), had no significant effects on the ROS induced by all three cytokines. hexose monophosphate 188-208 interferon gamma Homo sapiens 100-109 17765224-6 2007 NADPH oxidase inhibitor (diphenylene iodinium) abolished the ROS production induced by IL-1 beta or IFN-gamma, but not by TNF-alpha, whereas 6-aminonicotinamide (6AN), an inhibitor of the hexose monophosphate shunt (HMS), had no significant effects on the ROS induced by all three cytokines. Reactive Oxygen Species 256-259 interferon gamma Homo sapiens 100-109 17765224-3 2007 We investigated if pro-inflammatory cytokines, tumor necrosis factor (TNF)-alpha, interleukin-1 beta (IL-1 beta), and interferon-gamma (IFN-gamma), induce ROS in human retinal pigment epithelial (RPE) cells. Reactive Oxygen Species 155-158 interferon gamma Homo sapiens 118-134 17765224-7 2007 ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05). Reactive Oxygen Species 0-3 interferon gamma Homo sapiens 141-150 17765224-7 2007 ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05). pyrrolidine dithiocarbamic acid 16-42 interferon gamma Homo sapiens 141-150 17765224-7 2007 ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05). pyrrolidine dithiocarbamic acid 44-48 interferon gamma Homo sapiens 141-150 17765224-7 2007 ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05). Acetylcysteine 54-71 interferon gamma Homo sapiens 141-150 17765224-7 2007 ROS scavengers, pyrrolidinedithiocarbamate (PDTC) and N-acetyl-cysteine (NAC), reduced the levels of ROS induced by TNF-alpha, IL-1 beta and IFN-gamma (P<0.05). Acetylcysteine 73-76 interferon gamma Homo sapiens 141-150 17765224-8 2007 Collectively, these results demonstrate that TNF-alpha, IL-1 beta and IFN-gamma increase mitochondrial- and NADPH oxidase-generated ROS in human RPE cells. Reactive Oxygen Species 132-135 interferon gamma Homo sapiens 70-79 17765224-3 2007 We investigated if pro-inflammatory cytokines, tumor necrosis factor (TNF)-alpha, interleukin-1 beta (IL-1 beta), and interferon-gamma (IFN-gamma), induce ROS in human retinal pigment epithelial (RPE) cells. Reactive Oxygen Species 155-158 interferon gamma Homo sapiens 136-145 17765224-4 2007 TNF-alpha, IL-1 beta and IFN-gamma increased both intracellular and extracellular ROS production in a time- and dose-dependent manner. Reactive Oxygen Species 82-85 interferon gamma Homo sapiens 25-34 17765224-5 2007 Thenoyltrifluoroacetone (TTFA), an inhibitor of mitochondrial respiratory chain, blocked TNF-alpha- and IFN-gamma-, but not IL-1 beta-induced ROS, whereas other two mitochondrial respiratory chain inhibitors, rotenone and antimycin A, had no effect. Thenoyltrifluoroacetone 0-23 interferon gamma Homo sapiens 104-113 17765224-5 2007 Thenoyltrifluoroacetone (TTFA), an inhibitor of mitochondrial respiratory chain, blocked TNF-alpha- and IFN-gamma-, but not IL-1 beta-induced ROS, whereas other two mitochondrial respiratory chain inhibitors, rotenone and antimycin A, had no effect. Thenoyltrifluoroacetone 25-29 interferon gamma Homo sapiens 104-113 17765224-6 2007 NADPH oxidase inhibitor (diphenylene iodinium) abolished the ROS production induced by IL-1 beta or IFN-gamma, but not by TNF-alpha, whereas 6-aminonicotinamide (6AN), an inhibitor of the hexose monophosphate shunt (HMS), had no significant effects on the ROS induced by all three cytokines. diphenylene iodinium 25-45 interferon gamma Homo sapiens 100-109 17765224-6 2007 NADPH oxidase inhibitor (diphenylene iodinium) abolished the ROS production induced by IL-1 beta or IFN-gamma, but not by TNF-alpha, whereas 6-aminonicotinamide (6AN), an inhibitor of the hexose monophosphate shunt (HMS), had no significant effects on the ROS induced by all three cytokines. Reactive Oxygen Species 61-64 interferon gamma Homo sapiens 100-109 17546596-7 2007 T-cells were further characterized for IL- 2 and IFN-gamma production induced by PMA/Ionomycin. Tetradecanoylphorbol Acetate 81-84 interferon gamma Homo sapiens 49-58 17546596-7 2007 T-cells were further characterized for IL- 2 and IFN-gamma production induced by PMA/Ionomycin. Ionomycin 85-94 interferon gamma Homo sapiens 49-58 16542679-2 2007 Neopterin is a pteridine derivative, released from macrophages upon stimulation with pro-inflammatory cytokine interferon-gamma. Neopterin 0-9 interferon gamma Homo sapiens 111-127 17503465-4 2007 We demonstrated that in these cells, the tyrosine-phosphorylated form of STAT5 (PY-STAT5) increased and preferentially localized on podosomes together with Hck, instead of translocating to the nucleus as observed with conventional stimuli such as IFNgamma. Tyrosine 41-49 interferon gamma Homo sapiens 247-255 17626151-5 2007 hCG treatment of IFN-gamma-primed Mvarphi resulted in increased production of NO, reactive oxygen species, IL-6 and IL-12p40, and enhanced phagocytosis of apoptotic cells. Reactive Oxygen Species 82-105 interferon gamma Homo sapiens 17-26 17626151-8 2007 In vivo thioglycollate-elicited Mvarphi also exhibited increased phagocytic ability upon IFN-gamma activation and hCG treatment. Thioglycolates 8-22 interferon gamma Homo sapiens 89-98 16542679-2 2007 Neopterin is a pteridine derivative, released from macrophages upon stimulation with pro-inflammatory cytokine interferon-gamma. Pteridines 15-24 interferon gamma Homo sapiens 111-127 17903241-7 2007 RESULTS: Treatment of Human ASM cells with IL-13, IFN gamma or salmeterol for 24 hours lead to a modest augmentation of histamine induced IPx responses (144.3 +/- 9.3, 126.4 +/- 7.5 and 117.7 +/- 5.2%, p < 0.05). Histamine 120-129 interferon gamma Homo sapiens 50-59 17938259-4 2007 We and others have previously reported that IFN-gamma synergistically potentiates retinoic acid (RA)-induced sympathetic differentiation and growth inhibition in neuroblastoma cells. Tretinoin 82-95 interferon gamma Homo sapiens 44-53 17938259-4 2007 We and others have previously reported that IFN-gamma synergistically potentiates retinoic acid (RA)-induced sympathetic differentiation and growth inhibition in neuroblastoma cells. Tretinoin 97-99 interferon gamma Homo sapiens 44-53 17412377-4 2007 Doses of 120mg/kg of pentoxifylline effectively attenuated staphylococcal enterotoxin B-induced tumor necrosis factor alpha (TNFalpha), gamma interferon (IFNgamma) and interleukin 2 (IL-2) in ex vivo culture of NHP whole-blood cells by 88%, 81%, and 76%, respectively, whereas lower doses of 48 or 72mg/kg had no inhibitory effect. Pentoxifylline 21-35 interferon gamma Homo sapiens 136-163 17903241-7 2007 RESULTS: Treatment of Human ASM cells with IL-13, IFN gamma or salmeterol for 24 hours lead to a modest augmentation of histamine induced IPx responses (144.3 +/- 9.3, 126.4 +/- 7.5 and 117.7 +/- 5.2%, p < 0.05). 1,2-benzisothiazoline-3-one 138-141 interferon gamma Homo sapiens 50-59 17903241-8 2007 Similarly, TNFalpha, IFN gamma or salmeterol treatment augmented bradykinin induced IPx responses (127.4 +/- 8.3, 128.0 +/- 8.4 and 111.7 +/- 5.0%, P < 0.05). 1,2-benzisothiazoline-3-one 84-87 interferon gamma Homo sapiens 21-30 17686555-4 2007 IFNgamma production was dependent on formulation of the synthetic peptides with the adjuvant poly-l-arginine. polyarginine 93-108 interferon gamma Homo sapiens 0-8 17522338-2 2007 The molecular mechanism is widely thought to imply tryptophan degradation by the interferon-gamma (IFNgamma)-induced expression of indoleamine 2,3-dioxygenase (IDO). Tryptophan 51-61 interferon gamma Homo sapiens 81-97 17522338-2 2007 The molecular mechanism is widely thought to imply tryptophan degradation by the interferon-gamma (IFNgamma)-induced expression of indoleamine 2,3-dioxygenase (IDO). Tryptophan 51-61 interferon gamma Homo sapiens 99-107 17785828-6 2007 Mo-DCs matured by IFN-gamma and NadADelta351-405 supported the proliferation of naive CD4+ T lymphocytes, inducing the differentiation of both IFN-gamma and IL-4 producing phenotypes. nadadelta351 32-44 interferon gamma Homo sapiens 143-152 17785828-3 2007 Costimulation of mo-DCs with NadADelta351-405 and the imidoazoquinoline drug R-848, believed to mimic bacterial RNA, increased CD86 in an additive way, but strongly synergized the secretion of IL-12p70, IL-1, IL-6, TNF-alpha, and MIP-1alpha, especially after IFN-gamma priming. nadadelta351 29-41 interferon gamma Homo sapiens 259-268 17804388-3 2007 Poly(I:C) and loxoribine, in conjunction with IL-12, but not IL-15, triggered secretion of IFN-gamma. Poly I-C 0-8 interferon gamma Homo sapiens 91-100 17611194-7 2007 The PPARgamma agonist, troglitazone, sensitizes the cells to IFN-gamma treatment by increasing recruitment of PPARgamma to collagen gene while repressing collagen expression, and these effects are blocked by the PPARgamma antagonist T0070907. Troglitazone 23-35 interferon gamma Homo sapiens 61-70 17785715-3 2007 A study recently demonstrated that Pam3CSK {N-palmitoyl-S-[2,3-bis(palmitoloxy)-(2RS)-propyl]-Cys-Ser-Lys(4)}, a TLR2 agonist lipopeptide, activates T helper 1 (T(H)1) cells and induces interferon-gamma (IFN-gamma) production, even in the absence of TLR1, which differs from its mechanism of activation of APCs. n-palmitoyl-s-[2,3-bis(palmitoloxy)-(2rs)-propyl]-cys 44-97 interferon gamma Homo sapiens 186-202 17785715-3 2007 A study recently demonstrated that Pam3CSK {N-palmitoyl-S-[2,3-bis(palmitoloxy)-(2RS)-propyl]-Cys-Ser-Lys(4)}, a TLR2 agonist lipopeptide, activates T helper 1 (T(H)1) cells and induces interferon-gamma (IFN-gamma) production, even in the absence of TLR1, which differs from its mechanism of activation of APCs. n-palmitoyl-s-[2,3-bis(palmitoloxy)-(2rs)-propyl]-cys 44-97 interferon gamma Homo sapiens 204-213 17785715-3 2007 A study recently demonstrated that Pam3CSK {N-palmitoyl-S-[2,3-bis(palmitoloxy)-(2RS)-propyl]-Cys-Ser-Lys(4)}, a TLR2 agonist lipopeptide, activates T helper 1 (T(H)1) cells and induces interferon-gamma (IFN-gamma) production, even in the absence of TLR1, which differs from its mechanism of activation of APCs. Serine 98-101 interferon gamma Homo sapiens 186-202 17785715-3 2007 A study recently demonstrated that Pam3CSK {N-palmitoyl-S-[2,3-bis(palmitoloxy)-(2RS)-propyl]-Cys-Ser-Lys(4)}, a TLR2 agonist lipopeptide, activates T helper 1 (T(H)1) cells and induces interferon-gamma (IFN-gamma) production, even in the absence of TLR1, which differs from its mechanism of activation of APCs. Serine 98-101 interferon gamma Homo sapiens 204-213 17785715-3 2007 A study recently demonstrated that Pam3CSK {N-palmitoyl-S-[2,3-bis(palmitoloxy)-(2RS)-propyl]-Cys-Ser-Lys(4)}, a TLR2 agonist lipopeptide, activates T helper 1 (T(H)1) cells and induces interferon-gamma (IFN-gamma) production, even in the absence of TLR1, which differs from its mechanism of activation of APCs. Lysine 102-105 interferon gamma Homo sapiens 186-202 17785715-3 2007 A study recently demonstrated that Pam3CSK {N-palmitoyl-S-[2,3-bis(palmitoloxy)-(2RS)-propyl]-Cys-Ser-Lys(4)}, a TLR2 agonist lipopeptide, activates T helper 1 (T(H)1) cells and induces interferon-gamma (IFN-gamma) production, even in the absence of TLR1, which differs from its mechanism of activation of APCs. Lysine 102-105 interferon gamma Homo sapiens 204-213 17724360-2 2007 SUMMARY: Lenalidomide is an analogue of thalidomide and has been shown to be more potent than thalidomide in the stimulation of T-cell, interleukin-2, and interferon-gamma production. Lenalidomide 9-21 interferon gamma Homo sapiens 155-171 17724360-2 2007 SUMMARY: Lenalidomide is an analogue of thalidomide and has been shown to be more potent than thalidomide in the stimulation of T-cell, interleukin-2, and interferon-gamma production. Thalidomide 94-105 interferon gamma Homo sapiens 155-171 17609291-7 2007 Increased IDO activity promoted TEC apoptosis, whereas inhibition of IDO by its specific inhibitor 1-methyl-d-tryptophan attenuated IFN-gamma/TNF-alpha-mediated TEC apoptosis and augmented TEC survival. 1-methyltryptophan 99-120 interferon gamma Homo sapiens 132-141 17804388-3 2007 Poly(I:C) and loxoribine, in conjunction with IL-12, but not IL-15, triggered secretion of IFN-gamma. loxoribine 14-24 interferon gamma Homo sapiens 91-100 17804388-4 2007 Inhibition of IFN-gamma secretion by chloroquine suggested that internalization of the TLR agonists was necessary. Chloroquine 37-48 interferon gamma Homo sapiens 14-23 17804388-8 2007 Excitingly, IFN-gamma secretion was significantly increased when NK cells were stimulated with poly(I:C) or loxoribine and IL-12, and NKG2D engagement was induced by coculture with MICA+ tumor cells in a PI3K-dependent manner. Poly I-C 95-104 interferon gamma Homo sapiens 12-21 17804388-8 2007 Excitingly, IFN-gamma secretion was significantly increased when NK cells were stimulated with poly(I:C) or loxoribine and IL-12, and NKG2D engagement was induced by coculture with MICA+ tumor cells in a PI3K-dependent manner. loxoribine 108-118 interferon gamma Homo sapiens 12-21 17705132-7 2007 Mithramycin A, which blocks the binding of Sp1 to the T-BET promoter, diminished both T-BET expression and IFN-gamma protein production in monokine-stimulated primary human NK cells. mithramycin A 0-13 interferon gamma Homo sapiens 107-116 17804754-9 2007 On a total protein basis, Taxol induced ISMMC, expanded more CD8(+) cells, activated more CD56(+) NKG2D(+) cells to produce IFN-gamma, and were more potent inducers of high T-cell receptor density Perforin(+) cells than native ISMMC and peptide E75. Paclitaxel 26-31 interferon gamma Homo sapiens 124-133 18021470-0 2007 Synthetic imidazoquinolines potently and broadly activate the cellular immune response of patients with cutaneous T-cell lymphoma: synergy with interferon-gamma enhances production of interleukin-12. imidazoquinolines 10-27 interferon gamma Homo sapiens 144-160 17869645-6 2007 Both BAY- and ASA-allogeneic DC and autologous alloantigen pulsed DC were weaker stimulators of T cells (by MLR) compared with controls, and there was reduced IL-2 and IFN-gamma production by T cells stimulated with BAY-DC or ASA-DC (by ELISPOT) (more marked results were always observed with ASA-treated DC). Aspirin 14-17 interferon gamma Homo sapiens 168-177 17892399-0 2007 In vitro antihydatic action of IFN-gamma is dependent on the nitric oxide pathway. Nitric Oxide 61-73 interferon gamma Homo sapiens 31-40 17979888-7 2007 We report that curcumin decreases IL-12-induced STAT4 phosphorylation, IFN-gamma production, and IL-12 Rbeta1 and beta2 expression. Curcumin 15-23 interferon gamma Homo sapiens 71-80 17626075-9 2007 Importantly, the cytokine interleukin-1 abolished IFN-gamma-induced IDO enzyme activity in a nitric oxide-dependent manner without suppressing protein expression. Nitric Oxide 93-105 interferon gamma Homo sapiens 50-59 17562851-5 2007 In addition, the triterpene reduced the production of interleukin-2, interleukin-4, interleukin-10, and interferon-gamma in human T lymphocytes, and it hampered the induction of the principal cyclins involved in the cell cycle, including A(1), B(1), D(2), and E(1). Triterpenes 17-27 interferon gamma Homo sapiens 104-120 18073617-10 2007 Survival in the AET treatment group was associated with reduced levels of IL-6, IL-10, and IL-18, and enhanced IFN-gamma and IL-2 levels. beta-Aminoethyl Isothiourea 16-19 interferon gamma Homo sapiens 111-120 17593926-3 2007 The IN-defective sinLV elicited specific and long-lasting immune responses, as evaluated up to 90 days from the immunization by enzyme-linked immunosorbent spot (ELISPOT) and intracellular staining (ICS) for interferon-gamma (IFN-gamma) assays in both splenocytes and bone marrow (BM) cells, chromium release assay in splenocytes, and antibody detection in sera, without integration of the vector into the host genome. sinlv 17-22 interferon gamma Homo sapiens 208-224 17593926-3 2007 The IN-defective sinLV elicited specific and long-lasting immune responses, as evaluated up to 90 days from the immunization by enzyme-linked immunosorbent spot (ELISPOT) and intracellular staining (ICS) for interferon-gamma (IFN-gamma) assays in both splenocytes and bone marrow (BM) cells, chromium release assay in splenocytes, and antibody detection in sera, without integration of the vector into the host genome. sinlv 17-22 interferon gamma Homo sapiens 226-235 17953379-4 2007 The IFN-gamma CA-repeat polymorphism was determined by polymerase chain reaction and polyacrylamide gel electrophoresis with silver staining. polyacrylamide 85-99 interferon gamma Homo sapiens 4-13 17953379-4 2007 The IFN-gamma CA-repeat polymorphism was determined by polymerase chain reaction and polyacrylamide gel electrophoresis with silver staining. Silver 125-131 interferon gamma Homo sapiens 4-13 17764543-7 2007 For all cytokines except IFN gamma, the IC50 values for inhibition by cyclosporin A were similar in ABL and CBL. Cyclosporine 70-83 interferon gamma Homo sapiens 25-34 17535808-1 2007 The heme protein indoleamine 2,3-dioxygenase (IDO) is induced by the proinflammatory cytokine interferon-gamma (IFNgamma) and plays an important role in the immune response by catalyzing the oxidative degradation of L-tryptophan (Trp) that contributes to immune suppression and tolerance. Tryptophan 230-233 interferon gamma Homo sapiens 94-110 17535808-1 2007 The heme protein indoleamine 2,3-dioxygenase (IDO) is induced by the proinflammatory cytokine interferon-gamma (IFNgamma) and plays an important role in the immune response by catalyzing the oxidative degradation of L-tryptophan (Trp) that contributes to immune suppression and tolerance. Tryptophan 216-228 interferon gamma Homo sapiens 94-110 17535808-1 2007 The heme protein indoleamine 2,3-dioxygenase (IDO) is induced by the proinflammatory cytokine interferon-gamma (IFNgamma) and plays an important role in the immune response by catalyzing the oxidative degradation of L-tryptophan (Trp) that contributes to immune suppression and tolerance. Tryptophan 216-228 interferon gamma Homo sapiens 112-120 17535808-1 2007 The heme protein indoleamine 2,3-dioxygenase (IDO) is induced by the proinflammatory cytokine interferon-gamma (IFNgamma) and plays an important role in the immune response by catalyzing the oxidative degradation of L-tryptophan (Trp) that contributes to immune suppression and tolerance. Tryptophan 230-233 interferon gamma Homo sapiens 112-120 17889312-7 2007 Interferon (IFN)-gamma concentrations were lower in the alcohol consumption group at later times of infection. Alcohols 56-63 interferon gamma Homo sapiens 0-22 17635122-4 2007 A synergistic interaction between interferon gamma and monocyte-derived mediators drives high-level astrocyte MMP-9 secretion; this and other networking effects are inhibited by steroids. Steroids 178-186 interferon gamma Homo sapiens 34-50 17556653-3 2007 METHODS AND RESULTS: The effect of IFNgamma on COX-2 expression was evaluated in several types of human cells stimulated with phorbol 12-myristate 13-acetate (PMA), interleukin (IL)-1beta, or tumor necrosis factor (TNF) alpha. Tetradecanoylphorbol Acetate 126-157 interferon gamma Homo sapiens 35-43 17521318-7 2007 IFN-gamma also induced expression of indoleamine 2,3, dioxygenase (IDO), involved in tryptophan catabolism. Tryptophan 85-95 interferon gamma Homo sapiens 0-9 17489975-7 2007 RESULTS: In vitro activation of psoriatic as well as antigen (nickel)-specific skin-homing T cells was strongly and dose-dependently impaired by infliximab, in terms both of proliferation and of IFN-gamma release. Nickel 62-68 interferon gamma Homo sapiens 195-204 17671215-5 2007 Most patients were treated with zoledronate + IL-2, but conversely only two treated with zoledronate displayed a significant long-term shift of peripheral gammadelta cells toward an activated effector-memory-like state (T(EM)), producing IFN-gamma and perforin. Zoledronic Acid 89-100 interferon gamma Homo sapiens 238-247 17671141-9 2007 RESULTS: WT1 peptides 328-349 and 423-441 are able to stimulate a peptide-specific CD4(+) response that can recognize WT1(+) tumor cells in multiple HLA-DRB1 settings as determined by IFN-gamma enzyme-linked immunospot assays. Peptides 13-21 interferon gamma Homo sapiens 184-193 17627812-2 2007 In this study, IFN-gamma mediated up-regulation of caspase-8 in human MB cells was found to result in chemosensitization to cisplatin, doxorubicin and etoposide, and sensitisation to radiation. Cisplatin 124-133 interferon gamma Homo sapiens 15-24 17627812-2 2007 In this study, IFN-gamma mediated up-regulation of caspase-8 in human MB cells was found to result in chemosensitization to cisplatin, doxorubicin and etoposide, and sensitisation to radiation. Doxorubicin 135-146 interferon gamma Homo sapiens 15-24 17627812-2 2007 In this study, IFN-gamma mediated up-regulation of caspase-8 in human MB cells was found to result in chemosensitization to cisplatin, doxorubicin and etoposide, and sensitisation to radiation. Etoposide 151-160 interferon gamma Homo sapiens 15-24 17627812-4 2007 IFN-gamma mediated chemosensitization and radiosensitization effects were reduced by treatment with the caspase-8 specific inhibitor z-IETD-fmk. benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone 133-143 interferon gamma Homo sapiens 0-9 17521318-8 2007 Use of an antagonist, 1-methyl-L-tryptophan, restored alloresponsiveness and confirmed an IDO contribution to IFN-gamma-induced immunomodulation by MSC. 1-Methyl-L-tryptophan 22-43 interferon gamma Homo sapiens 110-119 17433076-5 2007 On stimulation with tumour necrosis factor-alpha, interferon-gamma and anti-CD40 monoclonal antibody, the GM-Monos predominantly produced IL-10 but were less efficient in IL-12 production. gm-monos 106-114 interferon gamma Homo sapiens 50-66 17560008-6 2007 RESULTS: It was demonstrated that imatinib inhibits antigen-specific IFN-gamma secretion of both CD4+ and CD8+ T-effector cells at therapeutically relevant concentrations, while T cells remain responsive. Imatinib Mesylate 34-42 interferon gamma Homo sapiens 69-78 17652735-13 2007 CONCLUSIONS: IFN-alpha and IFN-gamma enhance the susceptibility of HTFs to MMC-induced cell death through a Fas-mediated and a caspase-3-dependent pathway. Mitomycin 75-78 interferon gamma Homo sapiens 27-36 17570327-7 2007 Mixed lymphocyte reactions (MLRs) revealed that sinomenine-treated DC impede the secretion of the cytokines IL-2 and IFN-gamma by co-cultured CD4(+) T cells. sinomenine 48-58 interferon gamma Homo sapiens 117-126 17652735-0 2007 Interferon-alpha and interferon-gamma sensitize human tenon fibroblasts to mitomycin-C. Mitomycin 75-86 interferon gamma Homo sapiens 21-37 17652735-13 2007 CONCLUSIONS: IFN-alpha and IFN-gamma enhance the susceptibility of HTFs to MMC-induced cell death through a Fas-mediated and a caspase-3-dependent pathway. ammonium ferrous sulfate 108-111 interferon gamma Homo sapiens 27-36 17652735-1 2007 PURPOSE: To investigate the effect of interferon (IFN)-alpha and IFN-gamma pretreatment on mitomycin C (MMC)-induced cell death in human Tenon fibroblasts (HTFs) and the mechanisms by which IFN-alpha and IFN-gamma modulate the susceptibility of HTFs to MMC. Mitomycin 91-102 interferon gamma Homo sapiens 65-74 17522204-0 2007 Lambda interferon (IFN-lambda) in serum is decreased in hantavirus-infected patients, and in vitro-established infection is insensitive to treatment with all IFNs and inhibits IFN-gamma-induced nitric oxide production. Nitric Oxide 194-206 interferon gamma Homo sapiens 176-185 17526017-7 2007 Neurotoxicity of conditioned medium from human microglia and THP-1 monocytic cells stimulated with a combination of interferon-gamma (IFN-gamma) with either lipopolysaccharide (LPS) or alpha-synuclein was diminished by DHBP. 1,1'-diheptyl-4,4'-bipyridinium 219-223 interferon gamma Homo sapiens 116-132 17526017-7 2007 Neurotoxicity of conditioned medium from human microglia and THP-1 monocytic cells stimulated with a combination of interferon-gamma (IFN-gamma) with either lipopolysaccharide (LPS) or alpha-synuclein was diminished by DHBP. 1,1'-diheptyl-4,4'-bipyridinium 219-223 interferon gamma Homo sapiens 134-143 17475810-9 2007 According to its effect on IL-5 and IFN-gamma mRNA expression, UR-1505 specifically inhibited NF-AT DNA binding without effect on nuclear factor-kappaB and activator protein-1 activities. 2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic acid 63-70 interferon gamma Homo sapiens 36-45 17522204-1 2007 Hantaviruses, causing hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), are known to be sensitive to nitric oxide (NO) and to pretreatment with type I and II interferons (alpha interferon [IFN-alpha]/IFN-beta and IFN-gamma, respectively). Nitric Oxide 144-156 interferon gamma Homo sapiens 256-265 17391951-2 2007 The aim of this randomized, prospective, open-label study was to characterize the molecular effects of IFN-gamma-1b and colchicine, on biomarkers expression associated with fibrosis (TGF-beta, CTGF) and immunomodulatory/antimicrobial activity (IFN-gamma), in the lungs of patients with IPF. Colchicine 120-130 interferon gamma Homo sapiens 244-253 18044343-6 2007 Melatonin reduces levels of proinflammatory cytokines: IL-6, IL-12, TNF-alpha, IFN-gamma. Melatonin 0-9 interferon gamma Homo sapiens 79-88 17391951-9 2007 In addition, the IFN-gamma-1b group showed stability in arterial PO2 while the colchicine group significantly deteriorated (p=0.02). PO-2 65-68 interferon gamma Homo sapiens 17-26 17391951-10 2007 In conclusion, we report the effect of antifibrotic agents (IFN-gamma-1b and colchicine) in TGF-beta, CTGF, and endogenous IFN-gamma gene expression, in human fibrosis. Colchicine 77-87 interferon gamma Homo sapiens 123-132 17585980-7 2007 As observed, following in vivo exposure, in vitro treatment of human peripheral blood leukocytes with propanil resulted in a dose-dependent reduction in PHA-induced IFN-gamma and IL-10 production, while LPS-induced TNF-alpha production was not affected indicating a direct effect of propanil on selected immune parameters. Propanil 102-110 interferon gamma Homo sapiens 165-174 17579625-7 2007 At the protein level, IFN-gamma induced strong and prolonged STAT 1 activation at serine 727 (S727) in WM 1158R while in WM 1158S cells phosphorylation of this amino acid was much less pronounced. Serine 82-88 interferon gamma Homo sapiens 22-31 17585980-8 2007 We demonstrated that propanil interfering with PHA-induced intracellular calcium increase modulated IL-10 and IFN-gamma transcription and translation, which indicates that propanil acts on early events triggered by PHA. Propanil 21-29 interferon gamma Homo sapiens 110-119 17585980-8 2007 We demonstrated that propanil interfering with PHA-induced intracellular calcium increase modulated IL-10 and IFN-gamma transcription and translation, which indicates that propanil acts on early events triggered by PHA. Calcium 73-80 interferon gamma Homo sapiens 110-119 17585980-8 2007 We demonstrated that propanil interfering with PHA-induced intracellular calcium increase modulated IL-10 and IFN-gamma transcription and translation, which indicates that propanil acts on early events triggered by PHA. Propanil 172-180 interferon gamma Homo sapiens 110-119 17477920-0 2007 Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-gamma. Lycopene 0-8 interferon gamma Homo sapiens 85-94 17463418-8 2007 Vitamin D supplementation significantly enhanced the ability of participants" whole blood to restrict BCG-lux luminescence in vitro compared with placebo (mean luminescence ratio at follow-up, 0.57, vs. 0.71, respectively; 95% confidence interval for difference, 0.01-0.25; p=0.03) but did not affect antigen-stimulated IFN-gamma secretion. Vitamin D 0-9 interferon gamma Homo sapiens 320-329 17477920-0 2007 Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-gamma. Quercetin 10-19 interferon gamma Homo sapiens 85-94 17477920-3 2007 The IFN-gamma plus gliadin combination treatment was capable of enhancing iNOS and COX-2 gene expression and nuclear factor-kappaB (NF-kappaB), interferon regulatory factor-1 (IRF-1) and signal transducer and activator of transcription-1alpha (STAT-1alpha) activation induced by reactive oxygen species generation at 24 h. Lycopene, quercetin and tyrosol inhibited all these effects. 4-hydroxyphenylethanol 347-354 interferon gamma Homo sapiens 4-13 17477920-0 2007 Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-gamma. 4-hydroxyphenylethanol 24-31 interferon gamma Homo sapiens 85-94 17477920-3 2007 The IFN-gamma plus gliadin combination treatment was capable of enhancing iNOS and COX-2 gene expression and nuclear factor-kappaB (NF-kappaB), interferon regulatory factor-1 (IRF-1) and signal transducer and activator of transcription-1alpha (STAT-1alpha) activation induced by reactive oxygen species generation at 24 h. Lycopene, quercetin and tyrosol inhibited all these effects. Reactive Oxygen Species 279-302 interferon gamma Homo sapiens 4-13 17477920-3 2007 The IFN-gamma plus gliadin combination treatment was capable of enhancing iNOS and COX-2 gene expression and nuclear factor-kappaB (NF-kappaB), interferon regulatory factor-1 (IRF-1) and signal transducer and activator of transcription-1alpha (STAT-1alpha) activation induced by reactive oxygen species generation at 24 h. Lycopene, quercetin and tyrosol inhibited all these effects. Lycopene 323-331 interferon gamma Homo sapiens 4-13 17477920-3 2007 The IFN-gamma plus gliadin combination treatment was capable of enhancing iNOS and COX-2 gene expression and nuclear factor-kappaB (NF-kappaB), interferon regulatory factor-1 (IRF-1) and signal transducer and activator of transcription-1alpha (STAT-1alpha) activation induced by reactive oxygen species generation at 24 h. Lycopene, quercetin and tyrosol inhibited all these effects. Quercetin 333-342 interferon gamma Homo sapiens 4-13 17608386-0 2007 Review: commercial interferon-gamma release assays have high specificity but suboptimal sensitivity for detecting latent TB. Terbium 121-123 interferon gamma Homo sapiens 19-35 17565545-5 2007 RESULTS: The exposure of PBMC to dydrogesterone resulted in a significant inhibition in the production of the pro-inflammatory cytokines IFN-gamma and TNF-alpha and a significant increase in the levels of the anti-inflammatory cytokine IL-4, resulting in a substantial shift in the ratio of Th1/Th2 cytokines. PBMC 25-29 interferon gamma Homo sapiens 137-146 17573727-8 2007 Incubation of PBMC in vitro, with fluticasone propionate, decreased the p-CREB expression induced by cytokine activation (interferon-gamma, tumor necrosis factor-alpha). Fluticasone 34-56 interferon gamma Homo sapiens 122-167 17565545-5 2007 RESULTS: The exposure of PBMC to dydrogesterone resulted in a significant inhibition in the production of the pro-inflammatory cytokines IFN-gamma and TNF-alpha and a significant increase in the levels of the anti-inflammatory cytokine IL-4, resulting in a substantial shift in the ratio of Th1/Th2 cytokines. Dydrogesterone 33-47 interferon gamma Homo sapiens 137-146 17521962-4 2007 While the magnitude of single IFN-gamma secreting lymphocytes is similar between groups, the magnitude of peptide-specific dual IFN-gamma/IL-2 secreting lymphocytes is significantly more intense in SP. sp 198-200 interferon gamma Homo sapiens 128-137 17540780-2 2007 It is reported that butyrate inhibits IFN-gamma and TNF-alpha signaling pathways. Butyrates 20-28 interferon gamma Homo sapiens 38-47 17540780-4 2007 In transient transfection studies, NaB (5 mM) led to 10-fold stimulation of NHE3 promoter activity after incubation for 24 h. With 5"-deletion analysis, the NaB-responsive region was mapped to the NHE3 core promoter, bp -95 to + 5, which we had shown previously to confer responsiveness to IFN-gamma/TNF-alpha. nab 35-38 interferon gamma Homo sapiens 290-299 17540780-4 2007 In transient transfection studies, NaB (5 mM) led to 10-fold stimulation of NHE3 promoter activity after incubation for 24 h. With 5"-deletion analysis, the NaB-responsive region was mapped to the NHE3 core promoter, bp -95 to + 5, which we had shown previously to confer responsiveness to IFN-gamma/TNF-alpha. nab 157-160 interferon gamma Homo sapiens 290-299 17540780-5 2007 The stimulatory effect of NaB on the NHE3 promoter was reduced by 60% in the presence of IFN-gamma/TNF-alpha. nab 26-29 interferon gamma Homo sapiens 89-98 17695495-6 2007 However, the DCs pulsed with apoptotic TCs were best in stimulating interferon-gamma (INF-gamma) secretion as the effector function of autologous T-cells. Technetium 39-42 interferon gamma Homo sapiens 68-84 17695495-6 2007 However, the DCs pulsed with apoptotic TCs were best in stimulating interferon-gamma (INF-gamma) secretion as the effector function of autologous T-cells. Technetium 39-42 interferon gamma Homo sapiens 86-95 17363736-8 2007 MM plasma cells stimulated with IFN-gamma or TLR ligands inhibited cytotoxic T lymphocytes (CTLs) generation and this immunosuppressive effect was inhibited by preincubation with an anti-B7-H1 antibody, the UO126 MEK inhibitor, or by transfection of a dominant-negative mutant of MyD88. U 0126 207-212 interferon gamma Homo sapiens 32-41 17594193-2 2007 Tacrolimus inhibits the activation of an essential transcription factor for the transcription of cytokine genes in T cells leading to a decreased production of cytokines such as IL-2 and IFN-gamma. Tacrolimus 0-10 interferon gamma Homo sapiens 187-196 18958731-2 2007 This test detects the release of interferon-gamma (IFNgamma) in whole blood from sensitized persons when it is incubated with mixtures of synthetic peptides representing 2 proteins present in M. tuberculosis: early secretory antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10). Peptides 148-156 interferon gamma Homo sapiens 33-49 17416406-3 2007 METHODS: CD57 expression on beryllium-responsive IFN-gamma-expressing and IL-2-expressing CD4(+) T cells in blood and lung of 17 beryllium-sensitized and 20 CBD subjects was determined. Beryllium 28-37 interferon gamma Homo sapiens 49-58 17651018-7 2007 TUNEL and Hoechst staining also showed that IFN-gamma could induce apoptosis of human cytotrophoblast cells. hoechst 10-17 interferon gamma Homo sapiens 44-53 18958731-2 2007 This test detects the release of interferon-gamma (IFNgamma) in whole blood from sensitized persons when it is incubated with mixtures of synthetic peptides representing 2 proteins present in M. tuberculosis: early secretory antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10). Peptides 148-156 interferon gamma Homo sapiens 51-59 17613604-0 2007 Clinical response to glatiramer acetate correlates with modulation of IFN-gamma and IL-4 expression in multiple sclerosis. Glatiramer Acetate 21-39 interferon gamma Homo sapiens 70-79 17587351-5 2007 Plasma DHEA levels were positively correlated with IFN-gamma values. Dehydroepiandrosterone 7-11 interferon gamma Homo sapiens 51-60 17666360-5 2007 TPN supplemented with arginine resulted in significant increase in CD4+ T cells, NK cells and CD4+/CD8+ T cell ratio in the peripheral blood, as well as in IL-2 and IFN-gamma levels. Arginine 22-30 interferon gamma Homo sapiens 165-174 17666360-7 2007 CONCLUSION: TPN with arginine supplementation can augment the percentages of CD4+ T lymphocytes and NK cells, and increase IL-2 and IFN-gamma levels, suggesting that arginine can enhance cell-mediated immunity in postoperative patients with HCC. Arginine 21-29 interferon gamma Homo sapiens 132-141 17666360-7 2007 CONCLUSION: TPN with arginine supplementation can augment the percentages of CD4+ T lymphocytes and NK cells, and increase IL-2 and IFN-gamma levels, suggesting that arginine can enhance cell-mediated immunity in postoperative patients with HCC. Arginine 166-174 interferon gamma Homo sapiens 132-141 17587351-6 2007 An inverse correlation was found between the cortisol/DHEA ratio and IFN-gamma levels. Hydrocortisone 45-53 interferon gamma Homo sapiens 69-78 17587351-6 2007 An inverse correlation was found between the cortisol/DHEA ratio and IFN-gamma levels. Dehydroepiandrosterone 54-58 interferon gamma Homo sapiens 69-78 17618583-6 2007 Among these three TLR ligands, R-848 was the best one in induction of IFN-gamma production by PBMC. resiquimod 31-36 interferon gamma Homo sapiens 70-79 17618583-7 2007 FCM analysis indicated that R-848 could induce IFN-gamma expression by CD56(+) cells, but not CD4(+) or CD8(+) T cells. resiquimod 28-33 interferon gamma Homo sapiens 47-56 17536787-4 2007 In addition, direct binding of NKp44 to heparin was observed, and soluble heparin/heparan sulfate enhanced the secretion of IFNgamma by NK92 cells activated with anti-NKp44 monoclonal antibody. Heparin 74-81 interferon gamma Homo sapiens 124-132 17536787-4 2007 In addition, direct binding of NKp44 to heparin was observed, and soluble heparin/heparan sulfate enhanced the secretion of IFNgamma by NK92 cells activated with anti-NKp44 monoclonal antibody. Heparitin Sulfate 82-97 interferon gamma Homo sapiens 124-132 17460442-12 2007 The assay revealed that both CD4+ and CD4- T cells proliferated and produced IFN-gamma and TNF-alpha after stimulation with phenytoin. Phenytoin 124-133 interferon gamma Homo sapiens 77-86 18293704-10 2007 Thus, IFN-gamma, TNFalpha, IL-4, and IL5 production after 6 months-treatment decreased in moderate TB and increased in severe disease (p < 0.05). Terbium 99-101 interferon gamma Homo sapiens 6-15 17374532-4 2007 In the present study, we examined the effect of adenosine at increasing concentrations ranging from 0.1 to 100 microM on the IL-18-enhanced expression of ICAM-1, production of IFN-gamma and IL-12 and lymphocyte proliferation during human mixed lymphocyte reaction. Adenosine 48-57 interferon gamma Homo sapiens 176-185 17374532-6 2007 The IC(50) values of adenosine for inhibition of the IL-18-enhanced ICAM-1 expression, IFN-gamma production and lymphocyte proliferation were 20 microM, respectively. Adenosine 21-30 interferon gamma Homo sapiens 87-96 17408892-0 2007 Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression. Flavonoids 0-10 interferon gamma Homo sapiens 71-80 17408892-0 2007 Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression. centaurein 12-22 interferon gamma Homo sapiens 71-80 17408892-0 2007 Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression. centaureidin 27-39 interferon gamma Homo sapiens 71-80 17408892-4 2007 In contrast, hot water crude extracts from Bidens pilosa and its butanol subfraction increased IFN-gamma promoter activity to two- and six-fold, respectively. Butanols 65-72 interferon gamma Homo sapiens 95-104 17408892-5 2007 Finally, centaurein (EC(50)=75 microg/ml) and its aglycone, centaureidin (EC(50)=0.9 microg/ml), isolated from this butanol subfraction, augmented IFN-gamma promoter activity by approximately four-fold. centaurein 9-19 interferon gamma Homo sapiens 147-156 17408892-5 2007 Finally, centaurein (EC(50)=75 microg/ml) and its aglycone, centaureidin (EC(50)=0.9 microg/ml), isolated from this butanol subfraction, augmented IFN-gamma promoter activity by approximately four-fold. centaureidin 60-72 interferon gamma Homo sapiens 147-156 17512275-7 2007 RESULTS: IL-2- and IL-12-induced IFN-gamma production by PBMCs was suppressed significantly in both the OP (POD5) and SP groups compared with that in healthy controls. sp 118-120 interferon gamma Homo sapiens 33-42 17552910-3 2007 Gliovirin inhibited inducible TNF-alpha promoter activity and synthesis in LPS/IFN-gamma-stimulated macrophages/monocytes and Jurkat T-cells, co-stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA)/ionomycin, in a dose-dependent manner, with IC(50) values ranging from 0.21 to 2.1 microM (0.1-1 microg/ml). gliovirin 0-9 interferon gamma Homo sapiens 79-88 17552910-3 2007 Gliovirin inhibited inducible TNF-alpha promoter activity and synthesis in LPS/IFN-gamma-stimulated macrophages/monocytes and Jurkat T-cells, co-stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA)/ionomycin, in a dose-dependent manner, with IC(50) values ranging from 0.21 to 2.1 microM (0.1-1 microg/ml). Tetradecanoylphorbol Acetate 161-197 interferon gamma Homo sapiens 79-88 17552910-3 2007 Gliovirin inhibited inducible TNF-alpha promoter activity and synthesis in LPS/IFN-gamma-stimulated macrophages/monocytes and Jurkat T-cells, co-stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA)/ionomycin, in a dose-dependent manner, with IC(50) values ranging from 0.21 to 2.1 microM (0.1-1 microg/ml). Tetradecanoylphorbol Acetate 199-202 interferon gamma Homo sapiens 79-88 17552910-3 2007 Gliovirin inhibited inducible TNF-alpha promoter activity and synthesis in LPS/IFN-gamma-stimulated macrophages/monocytes and Jurkat T-cells, co-stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA)/ionomycin, in a dose-dependent manner, with IC(50) values ranging from 0.21 to 2.1 microM (0.1-1 microg/ml). Ionomycin 204-213 interferon gamma Homo sapiens 79-88 17509455-2 2007 IFNG +874T carriers were less frequent in MG, in patients with anti-acetylcholine receptor (AChR) (63%) and anti-titin (56.2%) antibodies compared with HC (p = 0.01 for all, OR: 0.5, 0.5, and 0.4, respectively). Acetylcholine 68-81 interferon gamma Homo sapiens 0-4 17009043-4 2007 The release of IFN-gamma and granzyme B by CD8+ T-lymphocytes specific for R3, a recently described T-cell epitope peptide derived from a leukemia-associated antigen designated RHAMM/CD168 (receptor for hyaluronic acid mediated motility), was inhibited by imatinib in a dose-dependent fashion (range: 1-25 microM). Imatinib Mesylate 256-264 interferon gamma Homo sapiens 15-24 17415381-6 2007 SB-mediated intratumoral gene transfer caused sustained IFN-gamma expression assessed by reverse transcription-polymerase chain reaction, of both vector-derived and endogenous IFN-gamma, whereas expression following episomal plasmid gene transfer was undetectable within 2 weeks. Antimony 0-2 interferon gamma Homo sapiens 56-65 17415381-6 2007 SB-mediated intratumoral gene transfer caused sustained IFN-gamma expression assessed by reverse transcription-polymerase chain reaction, of both vector-derived and endogenous IFN-gamma, whereas expression following episomal plasmid gene transfer was undetectable within 2 weeks. Antimony 0-2 interferon gamma Homo sapiens 176-185 17415381-7 2007 Median survival was enhanced further when SB-mediated IFN-gamma gene transfer was combined with CpG oligodeoxynucleotides as adjuvant therapy. Antimony 42-44 interferon gamma Homo sapiens 54-63 17346280-4 2007 Dimaprit, clobenpropit and clozapine, which are H4R agonists, dose-dependently blocked both PPD-induced interferon-gamma and Cry j1-induced interleukin-5 production by both peripheral blood mononuclear cells (PBMCs) and antigen-specific T-cell lines. Dimaprit 0-8 interferon gamma Homo sapiens 104-120 17346280-4 2007 Dimaprit, clobenpropit and clozapine, which are H4R agonists, dose-dependently blocked both PPD-induced interferon-gamma and Cry j1-induced interleukin-5 production by both peripheral blood mononuclear cells (PBMCs) and antigen-specific T-cell lines. clobenpropit 10-22 interferon gamma Homo sapiens 104-120 17346280-4 2007 Dimaprit, clobenpropit and clozapine, which are H4R agonists, dose-dependently blocked both PPD-induced interferon-gamma and Cry j1-induced interleukin-5 production by both peripheral blood mononuclear cells (PBMCs) and antigen-specific T-cell lines. Clozapine 27-36 interferon gamma Homo sapiens 104-120 17642401-11 2007 Discriminant probability analysis showed that from the total of 12 available parameters, a cluster of 6 (IFNgamma-SER, IFNgamma-PPD, IL-2R-SER, IL-10-SER, IL-10-NS and IL-6-PPD) predicted an 84% probability to become a TB contact upon exposure, 71% a chronic TB patient and 61% an acute TB patient. Serine 114-117 interferon gamma Homo sapiens 105-113 17513768-0 2007 IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. Vitamin D 31-40 interferon gamma Homo sapiens 0-18 17487393-5 2007 The concentration of IFN-gamma also increased in the supernatant of the NK-92 cells stimulated with FKN-HeLa cells. 3-[2-Chloro-5-(Methylsulfonyl)phenyl]-6-(2,4-Difluorophenoxy)-1h-Pyrazolo[3,4-D]pyrimidine 100-103 interferon gamma Homo sapiens 21-30 17127048-4 2007 The inhibitory effect of PD098059 on IFNgamma release was decreased in asthmatic T-cells compared with normals. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 25-33 interferon gamma Homo sapiens 37-45 17127048-6 2007 Dexamethasone blocked the IL-12-induced T-bet expression in asthmatic T-cells completely and decreased IL-12-induced IFNgamma release by approximately 50%, which occurred to the same extent in asthmatic and normal T-cells. Dexamethasone 0-13 interferon gamma Homo sapiens 117-125 17127048-8 2007 The therapeutic benefit of dexamethasone on T-bet and IFNgamma production seems to be critical. Dexamethasone 27-40 interferon gamma Homo sapiens 54-62 17580130-7 2007 The IFN-gamma concentrations correlated negatively with xanthine (Xan) concentrations in renal vein blood during reperfusion, whereas there was a positive correlation between IL-2 and Xan concentrations. Xanthine 56-64 interferon gamma Homo sapiens 4-13 17461594-2 2007 We evaluated the PE effect on RAW 264.7 macrophages stimulated with lipopolysaccharide plus interferon-gamma that show a rapid enhanced production of prostaglandin E2 (PGE2) and nitric oxide (NO). Dinoprostone 150-166 interferon gamma Homo sapiens 92-108 17461594-2 2007 We evaluated the PE effect on RAW 264.7 macrophages stimulated with lipopolysaccharide plus interferon-gamma that show a rapid enhanced production of prostaglandin E2 (PGE2) and nitric oxide (NO). Dinoprostone 168-172 interferon gamma Homo sapiens 92-108 17461594-2 2007 We evaluated the PE effect on RAW 264.7 macrophages stimulated with lipopolysaccharide plus interferon-gamma that show a rapid enhanced production of prostaglandin E2 (PGE2) and nitric oxide (NO). Nitric Oxide 178-190 interferon gamma Homo sapiens 92-108 16947022-7 2007 Interestingly, both T98G and U87MG cells showed more increase in apoptosis with expression of the HLA class II components for an effective immune response following treatment with ATRA plus IFN-gamma than with IFN-gamma alone. Tretinoin 180-184 interferon gamma Homo sapiens 210-219 17493524-11 2007 The expression of HLA-DR and HLA-DP on pA3408-positive chondrocytes in response to IFN-gamma decreased 73.00%+/-5.24%, 88.47%+/-2.02%, respectively (P<0.05); So did the content of CII TA mRNA (70.11%+/-5.79%, P<0.05). pa3408 39-45 interferon gamma Homo sapiens 83-92 17436234-7 2007 Levels of interleukin (IL)-6, IL-8, IL-10, interferon (IFN)-gamma, and macrophage inflammatory protein (MIP)-1beta were significantly inversely correlated with the duration of supplemental-oxygen therapy. Oxygen 189-195 interferon gamma Homo sapiens 43-65 17303795-7 2007 The number of cells expressing IFN-gamma showed a trend toward fewer in smoker (70 [6, 24]) versus never-smoker steroid-naive patients with asthma (144 [44, 323]; p = 0.10). Steroids 112-119 interferon gamma Homo sapiens 31-40 17504122-6 2007 The latter mediate Imatinib/IL-2-induced regression of tumors in pre-clinical animal models via production of high amounts of IFN-gamma and the death receptor ligand TRAIL. Imatinib Mesylate 19-27 interferon gamma Homo sapiens 126-135 17255201-9 2007 Prolactin modestly or IFN-gamma greatly induced tyrosine phosphorylation of STAT1, and both were suppressed by JAK inhibitor. Tyrosine 48-56 interferon gamma Homo sapiens 22-31 17255201-10 2007 Prolactin modestly or IFN-gamma greatly induced serine phosphorylation of STAT1, which was suppressed by MEK or p38 MAPK inhibitor, respectively. Serine 48-54 interferon gamma Homo sapiens 22-31 17335887-10 2007 Both rIL-23 and rIL-12 enhanced IFN-gamma production. ril-23 5-11 interferon gamma Homo sapiens 32-41 17224841-6 2007 In contrast to polymethylmethacrylate, titanium particles stimulated increased expression of T lymphocyte-derived cytokines, including interleukin 2, interferon gamma, interleukin 9, and interleukin 22, in peripheral blood mononuclear cell cultures. Titanium 39-47 interferon gamma Homo sapiens 150-166 17369187-6 2007 NKR-P2 cross-linking with 1A6 also induced the secretion of inflammatory cytokines, IL-1beta, tumor necrosis factor-alpha, IFN-gamma and IL-12 by DCs. 3-{[(3-Methyl-1,2-Oxazol-5-Yl)methyl]sulfanyl}[1,2,4]triazolo[4,3-A]pyridine 26-29 interferon gamma Homo sapiens 123-132 17393132-1 2007 Two years ago, CE certified interferon-gamma release assays (IGRA) were launched on the German market (QuantiFERON-TB Gold In-Tube and T-SPOT-TB). tb gold 115-122 interferon gamma Homo sapiens 28-44 17284681-4 2007 The results showed that (S)-armepavine suppressed PHA-induced PBMC proliferation and genes expression of IL-2 and IFN-gamma without direct cytotoxicity. armepavine 24-38 interferon gamma Homo sapiens 114-123 17113763-1 2007 Neopterin is synthesized by human monocyte-derived macrophages upon stimulation with interferon-gamma (IFN-gamma). Neopterin 0-9 interferon gamma Homo sapiens 85-101 17348040-6 2007 The downregulation of HSP60 and HSP10 by NO were confirmed in vitro, wherein HSP10 and SHP60 expressions were increased by treatment of LPS and IFN gamma (LPS/INF gamma) in C6 astroglioma cells and further upregulated by NMMA, another iNOS inhibitor. N-methylmalonamic acid 221-225 interferon gamma Homo sapiens 144-153 17113763-1 2007 Neopterin is synthesized by human monocyte-derived macrophages upon stimulation with interferon-gamma (IFN-gamma). Neopterin 0-9 interferon gamma Homo sapiens 103-112 17363222-0 2007 Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro. Risperidone 0-11 interferon gamma Homo sapiens 35-51 17346677-7 2007 Further, AG825 pretreatment restored the anti-proliferation activity of IFN-gamma in TCC-N5 and TCC-N10 cells. tyrphostin AG825 9-14 interferon gamma Homo sapiens 72-81 17387159-2 2007 The interaction of the lifelong persisting parasite with the host"s immune system involves T-cell/interferon-gamma-induced degradation of tryptophan and provides a challenge to the host well beyond a possible role in the etiology of schizophrenia. Tryptophan 138-148 interferon gamma Homo sapiens 98-114 17402996-11 2007 Rectal nitric oxide levels parallel down-regulation of inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin-1beta and interferon-gamma and may serve as a quantitative biomarker of intestinal inflammation. Nitric Oxide 7-19 interferon gamma Homo sapiens 139-155 17316566-7 2007 Naive T cells co-cultured with Sugiol-primed DC, turned into typical Th2 which produced large quantities of IL-4 and released small amounts of IFN-gamma and reduced Th1 cell polarizing capacity. sugiol 31-37 interferon gamma Homo sapiens 143-152 17404310-0 2007 IFN-gamma induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes. cysteinyl-leukotriene 124-146 interferon gamma Homo sapiens 0-9 17404310-3 2007 IFN-gamma increased cysLT receptor 2 (CysLTR2) mRNA expression and CysLTR2-specific calcium signaling in endothelial cells. Calcium 84-91 interferon gamma Homo sapiens 0-9 17404310-12 2007 This response was mediated by CysLTR2 coupled to G(q/11), activation of phospholipase C, and inositol-1,4,5-triphosphate, and was enhanced further 2- to 5-fold by IFN-gamma stimulation. Inositol 1,4,5-Trisphosphate 93-120 interferon gamma Homo sapiens 163-172 16837131-0 2007 Deferoxamine enhances anti-proliferative effect of interferon-gamma against hepatocellular carcinoma cells. Deferoxamine 0-12 interferon gamma Homo sapiens 51-67 17306826-3 2007 By contrast, using target cells silenced via a formaldehyde-based fixation-protocol, we demonstrate feasibility to detect - in a true one-way reaction - secretion of IFNgamma by alloreactive NK cells. Formaldehyde 47-59 interferon gamma Homo sapiens 166-174 16837131-3 2007 The aims of this study were to investigate whether iron chelation, blocking of the human insulin-like growth factor-1 receptor (hIGF1R), or both could upregulate IFN-gammaR2 and enhance the anti-proliferative effect of IFN-gamma. Iron 51-55 interferon gamma Homo sapiens 162-171 16837131-6 2007 The anti-proliferative effect of IFN-gamma was investigated by MTT assay, and the pro-apoptotic effect was investigated by annexin-V flow cytometry. monooxyethylene trimethylolpropane tristearate 63-66 interferon gamma Homo sapiens 33-42 16837131-8 2007 DFO, anti-hIGF1R blocking antibody, or both directly enhanced the anti-proliferative effect of IFN-gamma through increased pro-apoptotic activity. Deferoxamine 0-3 interferon gamma Homo sapiens 95-104 16837131-9 2007 CONCLUSION: The present results indicate that IFN-gamma reinforced by iron modulation could be a promising new therapeutic approach for HCC. Iron 70-74 interferon gamma Homo sapiens 46-55 17430115-0 2007 Implications of IFN-gamma-mediated tryptophan catabolism on solid organ transplantation. Tryptophan 35-45 interferon gamma Homo sapiens 16-25 17362940-1 2007 The present report provides evidence that, in A431 cells, interferon gamma (IFNgamma) induces the rapid (within 5 min), and reversible, tyrosine phosphorylation of the epidermal growth factor receptor (EGFR). Tyrosine 136-144 interferon gamma Homo sapiens 58-85 17430107-0 2007 Substrate and cofactor requirements of indoleamine 2,3-dioxygenase in interferon-gamma-treated cells: utilization of oxygen rather than superoxide. Oxygen 57-63 interferon gamma Homo sapiens 70-86 17430111-2 2007 Patients show highly elevated serum/plasma concentrations of the proinflammatory cytokine interferon-gamma (IFN-gamma), which induces human monocytes to form neopterin, to produce reactive oxygen species (ROS) and in parallel, to degrade tryptophan. Neopterin 158-167 interferon gamma Homo sapiens 90-106 17430111-2 2007 Patients show highly elevated serum/plasma concentrations of the proinflammatory cytokine interferon-gamma (IFN-gamma), which induces human monocytes to form neopterin, to produce reactive oxygen species (ROS) and in parallel, to degrade tryptophan. Neopterin 158-167 interferon gamma Homo sapiens 108-117 16900358-8 2007 Conversely, eye drops preserved with benzalkonium chloride (BAC) induced even higher ICAM-1 expression levels on IFN gamma-stimulated cells than did IFN gamma alone, whereas unpreserved drugs had no effect. Benzalkonium Compounds 37-58 interferon gamma Homo sapiens 113-122 17430111-2 2007 Patients show highly elevated serum/plasma concentrations of the proinflammatory cytokine interferon-gamma (IFN-gamma), which induces human monocytes to form neopterin, to produce reactive oxygen species (ROS) and in parallel, to degrade tryptophan. Reactive Oxygen Species 180-203 interferon gamma Homo sapiens 90-106 17430111-2 2007 Patients show highly elevated serum/plasma concentrations of the proinflammatory cytokine interferon-gamma (IFN-gamma), which induces human monocytes to form neopterin, to produce reactive oxygen species (ROS) and in parallel, to degrade tryptophan. Reactive Oxygen Species 180-203 interferon gamma Homo sapiens 108-117 17430111-2 2007 Patients show highly elevated serum/plasma concentrations of the proinflammatory cytokine interferon-gamma (IFN-gamma), which induces human monocytes to form neopterin, to produce reactive oxygen species (ROS) and in parallel, to degrade tryptophan. Reactive Oxygen Species 205-208 interferon gamma Homo sapiens 90-106 17430111-2 2007 Patients show highly elevated serum/plasma concentrations of the proinflammatory cytokine interferon-gamma (IFN-gamma), which induces human monocytes to form neopterin, to produce reactive oxygen species (ROS) and in parallel, to degrade tryptophan. Reactive Oxygen Species 205-208 interferon gamma Homo sapiens 108-117 17430111-2 2007 Patients show highly elevated serum/plasma concentrations of the proinflammatory cytokine interferon-gamma (IFN-gamma), which induces human monocytes to form neopterin, to produce reactive oxygen species (ROS) and in parallel, to degrade tryptophan. Tryptophan 238-248 interferon gamma Homo sapiens 90-106 17430111-2 2007 Patients show highly elevated serum/plasma concentrations of the proinflammatory cytokine interferon-gamma (IFN-gamma), which induces human monocytes to form neopterin, to produce reactive oxygen species (ROS) and in parallel, to degrade tryptophan. Tryptophan 238-248 interferon gamma Homo sapiens 108-117 17430111-5 2007 IDO and other IFN-gamma-mediated pathways are strongly induced in patients with HIV infection and are also linked with disease progression: Neopterin formation by GTP-cyclohydrolase I sensitively reflects the stage of the disease, and determination of the pteridine in body fluids is useful to monitor the efficacy of antiretroviral therapy. Neopterin 140-149 interferon gamma Homo sapiens 14-23 17430111-5 2007 IDO and other IFN-gamma-mediated pathways are strongly induced in patients with HIV infection and are also linked with disease progression: Neopterin formation by GTP-cyclohydrolase I sensitively reflects the stage of the disease, and determination of the pteridine in body fluids is useful to monitor the efficacy of antiretroviral therapy. Pteridines 256-265 interferon gamma Homo sapiens 14-23 17349923-0 2007 Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation. Phosphatidylserines 0-18 interferon gamma Homo sapiens 89-105 17349923-0 2007 Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation. Phosphatidylcholines 23-42 interferon gamma Homo sapiens 89-105 16900358-8 2007 Conversely, eye drops preserved with benzalkonium chloride (BAC) induced even higher ICAM-1 expression levels on IFN gamma-stimulated cells than did IFN gamma alone, whereas unpreserved drugs had no effect. Benzalkonium Compounds 60-63 interferon gamma Homo sapiens 113-122 17307798-1 2007 CD160 NK cell-activating receptor is a glycosyl-phosphatidylinositol-anchored molecule that, upon specific engagement, triggers both cytotoxicity and a unique cytokine production [IFN-gamma, tumor necrosis factor-alpha (TNF-alpha) and IL-6] through an undefined signaling pathway. Glycosylphosphatidylinositols 39-68 interferon gamma Homo sapiens 180-189 17485888-7 2007 Treatment of the cells with phorbol 12-myristate 13-acetate, which induces the differentiation of the cells into macrophage-like cells, significantly enhanced the IFN-gamma -induced RIG-I expression. Tetradecanoylphorbol Acetate 28-59 interferon gamma Homo sapiens 163-172 17404623-6 2007 Neutralization of IFN-gamma or IDO triggered acute allograft rejection in both CD40Ig-treated and adoptively transferred recipients. cd40ig 79-85 interferon gamma Homo sapiens 18-27 17235328-4 2007 Dimethylfumarate (DMF) and diethylfumarate (DEF), but not fumaric acid, methylhydrogenfumarate and ethylhydrogenfumarate, exhibited potent depression of inflammatory cytokine secretion (e.g., tumor necrosis factoralpha, IL-12, and IFNgamma) in activated human peripheral blood mononuclear cells. Dimethyl Fumarate 0-16 interferon gamma Homo sapiens 231-239 17401714-5 2007 IFN-gamma responses were measured using the commercial whole-blood Quanti-FERON-TB Gold In Tube (QFT-G) assay at three time-points: at diagnosis (N = 60), after 2 months of intensive treatment (N = 47), and at 6 months (treatment completion) (N = 39). feron-tb gold 74-87 interferon gamma Homo sapiens 0-9 16920192-0 2007 Retinoic acid-induced CD38 antigen promotes leukemia cells attachment and interferon-gamma/interleukin-1beta-dependent apoptosis of endothelial cells: implications in the etiology of retinoic acid syndrome. Tretinoin 0-13 interferon gamma Homo sapiens 74-90 16920192-4 2007 In the present study, we found that RA treatment induces the expression of interferon-gamma (IFN-gamma) and interleukin-1beta (IL-1beta) in peripheral blast cells from APL patients. Tretinoin 36-38 interferon gamma Homo sapiens 75-91 16920192-4 2007 In the present study, we found that RA treatment induces the expression of interferon-gamma (IFN-gamma) and interleukin-1beta (IL-1beta) in peripheral blast cells from APL patients. Tretinoin 36-38 interferon gamma Homo sapiens 93-102 17235328-4 2007 Dimethylfumarate (DMF) and diethylfumarate (DEF), but not fumaric acid, methylhydrogenfumarate and ethylhydrogenfumarate, exhibited potent depression of inflammatory cytokine secretion (e.g., tumor necrosis factoralpha, IL-12, and IFNgamma) in activated human peripheral blood mononuclear cells. Dimethyl Fumarate 18-21 interferon gamma Homo sapiens 231-239 17235328-4 2007 Dimethylfumarate (DMF) and diethylfumarate (DEF), but not fumaric acid, methylhydrogenfumarate and ethylhydrogenfumarate, exhibited potent depression of inflammatory cytokine secretion (e.g., tumor necrosis factoralpha, IL-12, and IFNgamma) in activated human peripheral blood mononuclear cells. diethyl fumarate 27-42 interferon gamma Homo sapiens 231-239 17235328-4 2007 Dimethylfumarate (DMF) and diethylfumarate (DEF), but not fumaric acid, methylhydrogenfumarate and ethylhydrogenfumarate, exhibited potent depression of inflammatory cytokine secretion (e.g., tumor necrosis factoralpha, IL-12, and IFNgamma) in activated human peripheral blood mononuclear cells. diethyl fumarate 44-47 interferon gamma Homo sapiens 231-239 17331846-5 2007 RESULTS: The quantities of IFN-gamma and IL-4 secreted by lymphocytes per microliter in the three mixture grafts were 2- to 4-fold lower than in G-PB and 1- to 3-fold higher than in SS-BM and G-BM, while the IL-4/IFN-gamma ratio was higher than SS-BM and G-PB and lower than G-BM, although no significant difference was confirmed. ss-bm 245-250 interferon gamma Homo sapiens 27-36 17251186-7 2007 In contrast, in intestinal epithelial cells, butyrate significantly enhanced the expression of iNOS and the production of NO in response to treatment with LPS/IFNgamma. Butyrates 45-53 interferon gamma Homo sapiens 159-167 17536259-0 2007 [Effects of triptolide on the production of interferon-gamma in human peripheral blood mononuclear cell and phosphorylation of signal transducer and activator of transcription-1 and production of interleukin-8]. triptolide 12-22 interferon gamma Homo sapiens 44-60 17536259-1 2007 OBJECTIVE: To investigate the effects of triptolide on the production of interferon-gamma (IFN-gamma) in human peripheral blood mononuclear cell (PBMC) and interleukin-8 (IL-8) in HaCaT keratinocytes and phosphorylation of signal transducer and activator of transcription-1 (STAT1) of IFN-gamma signal transduction pathways in HaCaT cells. triptolide 41-51 interferon gamma Homo sapiens 73-89 17536259-1 2007 OBJECTIVE: To investigate the effects of triptolide on the production of interferon-gamma (IFN-gamma) in human peripheral blood mononuclear cell (PBMC) and interleukin-8 (IL-8) in HaCaT keratinocytes and phosphorylation of signal transducer and activator of transcription-1 (STAT1) of IFN-gamma signal transduction pathways in HaCaT cells. triptolide 41-51 interferon gamma Homo sapiens 91-100 17536259-9 2007 Triptolide can inhibit the phosphorylations of STAT1 of IFN-gamma signal pathway in HaCaT keratinocytes stimulated by IFN-gamma. triptolide 0-10 interferon gamma Homo sapiens 56-65 17536259-9 2007 Triptolide can inhibit the phosphorylations of STAT1 of IFN-gamma signal pathway in HaCaT keratinocytes stimulated by IFN-gamma. triptolide 0-10 interferon gamma Homo sapiens 118-127 17254563-5 2007 The IC50 values of nicotine for inhibition of the IL-18-enhanced ICAM-1 expression, IFN-gamma production and proliferation were 1, 1 and 2 microM, respectively. Nicotine 19-27 interferon gamma Homo sapiens 84-93 17343921-1 2007 We have reported that NK cells from HIV-infected progressors showed a markedly lower IFN-gamma production in response to an A-class CpG oligodeoxynucleotide as compared to LTNP subjects and healthy HIV-negative individuals. Oligodeoxyribonucleotides 136-156 interferon gamma Homo sapiens 85-94 17339440-6 2007 By temporally controlling the expression of T-bet-estrogen receptor alpha by the addition or removal of 4-hydroxytamoxifen (4-HT), we show that IFN-gamma, CD122, and CxCR3 are direct gene targets of T-bet whose expression are acutely regulated by T-bet activity. hydroxytamoxifen 104-122 interferon gamma Homo sapiens 144-153 17310143-7 2007 KEY RESULTS: Adenosine inhibited the IL-18-induced up-regulation of ICAM-1 on human monocytes and it abolished the IL-18-enhanced production of IL-12, IFN-gamma and TNF-alpha. Adenosine 13-22 interferon gamma Homo sapiens 151-160 17360885-1 2007 Low levels of dehydroepiandrosterone (DHEA) and cortisol hormones produced by the suprarenal cortex have been associated with diseases involving chronic inflammation, low interferon (IFN)-gamma, and high interleukin (IL)-6. Dehydroepiandrosterone 14-36 interferon gamma Homo sapiens 171-193 17360885-1 2007 Low levels of dehydroepiandrosterone (DHEA) and cortisol hormones produced by the suprarenal cortex have been associated with diseases involving chronic inflammation, low interferon (IFN)-gamma, and high interleukin (IL)-6. Dehydroepiandrosterone 38-42 interferon gamma Homo sapiens 171-193 17291992-4 2007 Inhibition of NO production by aminoguanidine increased, whereas sodium nitroprusside (SNP; an exogenous NO generator) reduced, nuclear c-rel levels in LPS + IFN-gamma-activated RAW 264.7 macrophages. Nitroprusside 65-85 interferon gamma Homo sapiens 158-167 17550137-9 2007 Interferon-gamma co-treatment increased the stability of p53 protein induced by adriamycin. Doxorubicin 80-90 interferon gamma Homo sapiens 0-16 17218153-4 2007 Further, significantly elevated levels of IFN-gamma, NO and CRP were observed in sodium antimony gluconate (SAG) unresponsive cases compared to responsive cases. Antimony Sodium Gluconate 81-106 interferon gamma Homo sapiens 42-51 17218153-4 2007 Further, significantly elevated levels of IFN-gamma, NO and CRP were observed in sodium antimony gluconate (SAG) unresponsive cases compared to responsive cases. Antimony Sodium Gluconate 108-111 interferon gamma Homo sapiens 42-51 17039239-3 2007 Notably, extracellular ATP displayed a complex regulation of IFN-gamma-stimulated chemokine expression, with upregulation of CC chemokine ligand 2 (CCL2), CCL5 and CXC chemokine ligand 8 (CXCL8), and suppression of the receptor CXC chemokine receptor 3 (CXCR3), CXCL9, CXCL10, and CXCL11. Adenosine Triphosphate 23-26 interferon gamma Homo sapiens 61-70 17304101-1 2007 In human neutrophils, interferon (IFN)-gamma enhanced the expression of toll-like receptor 4 (TLR4), a crucial component of the signaling receptor complex for bacterial lipopolysaccharide (LPS). bacterial lipopolysaccharide 159-187 interferon gamma Homo sapiens 22-44 16868770-1 2007 Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response. Pteridines 0-9 interferon gamma Homo sapiens 133-149 16868770-1 2007 Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response. Pteridines 0-9 interferon gamma Homo sapiens 151-160 16868770-1 2007 Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response. Neopterin 22-31 interferon gamma Homo sapiens 133-149 16868770-1 2007 Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response. Neopterin 22-31 interferon gamma Homo sapiens 151-160 16868770-1 2007 Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response. 7,8-dihydroneopterin 36-56 interferon gamma Homo sapiens 133-149 16868770-1 2007 Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response. 7,8-dihydroneopterin 36-56 interferon gamma Homo sapiens 151-160 16868770-9 2007 Results suggest that the increased production of neopterin derivatives by activated macrophages and dendritic cells may represent part of the antiviral armature induced by IFN-gamma. Neopterin 49-58 interferon gamma Homo sapiens 172-181 17378751-4 2007 METHODS: Lipopolysaccharide (LPS)and phorbol 12-myristate 13-acetate plus ionomycin (PMA + I)-stimulated PBMC MCP-1 and IFNgamma production were determined in six extremely obese subjects (body mass index [BMI] = 62.4 +/- 8.6 kg/m(2)) before and 1 year after gastric bypass surgery and in six age-matched lean subjects (BMI = 22.7 +/- 1.4 kg/m(2)). Ionomycin 74-83 interferon gamma Homo sapiens 120-128 17309780-3 2007 Upon stimulation with phorbol 12-myristate acetate/ionomycin for 6 h, tuberculin-negative patients had a significantly higher proportion of IFN-gamma-producing CD4(+) T lymphocytes in BALF than in peripheral blood, while both CD4(+) and CD8(+) T-lymphocyte subsets in BALF of tuberculin-positive patients secreted more IFN-gamma than their peripheral blood counterparts. phorbol 12-myristate acetate 22-50 interferon gamma Homo sapiens 140-149 17309780-3 2007 Upon stimulation with phorbol 12-myristate acetate/ionomycin for 6 h, tuberculin-negative patients had a significantly higher proportion of IFN-gamma-producing CD4(+) T lymphocytes in BALF than in peripheral blood, while both CD4(+) and CD8(+) T-lymphocyte subsets in BALF of tuberculin-positive patients secreted more IFN-gamma than their peripheral blood counterparts. phorbol 12-myristate acetate 22-50 interferon gamma Homo sapiens 319-328 17309780-3 2007 Upon stimulation with phorbol 12-myristate acetate/ionomycin for 6 h, tuberculin-negative patients had a significantly higher proportion of IFN-gamma-producing CD4(+) T lymphocytes in BALF than in peripheral blood, while both CD4(+) and CD8(+) T-lymphocyte subsets in BALF of tuberculin-positive patients secreted more IFN-gamma than their peripheral blood counterparts. Ionomycin 51-60 interferon gamma Homo sapiens 140-149 17309780-3 2007 Upon stimulation with phorbol 12-myristate acetate/ionomycin for 6 h, tuberculin-negative patients had a significantly higher proportion of IFN-gamma-producing CD4(+) T lymphocytes in BALF than in peripheral blood, while both CD4(+) and CD8(+) T-lymphocyte subsets in BALF of tuberculin-positive patients secreted more IFN-gamma than their peripheral blood counterparts. Ionomycin 51-60 interferon gamma Homo sapiens 319-328 17304101-3 2007 Using the protein synthesis inhibitor cycloheximide and measuring the expression of CD35 in neutrophils stimulated with IFN-gamma and LPS alone or in combination, we could demonstrate that IFN-gamma enhances TLR4 by de novo protein synthesis, whereas the addition of LPS acts synergistically by enhancing vesicular mobilization to the cell surface. Cycloheximide 38-51 interferon gamma Homo sapiens 189-198 17580685-6 2007 Recombinant human interferon-gamma (rhIFN-gamma) was purified with simultaneous renaturation by high performance hydrophobic interaction chromatography (HPH-IC) using a stationary phase with an end group of PEG-200. Polyox WSR-N 60 207-214 interferon gamma Homo sapiens 18-34 17343783-5 2007 The effects were more obviously in both IFN-alpha+ATRA group and IFN-gamma+ATRA group. Tretinoin 75-79 interferon gamma Homo sapiens 65-74 17277112-3 2007 Hepatic (alpha-galactosyl-ceramide-loaded CD1d dimer binding) NKT cells produce predominantly IL-4 when stimulated with glycolipid-presenting HC but predominantly IFN-gamma when stimulated with glycolipid-presenting dendritic cells. alpha-galactosylceramide 9-34 interferon gamma Homo sapiens 163-172 17343783-0 2007 [Experimental study of IFN-alpha and IFN-gamma on reversing ATRA-resistance in MR2 cell line]. Tretinoin 60-64 interferon gamma Homo sapiens 37-46 17343783-1 2007 AIM: To explore the possibility and the possible mechanism of reversing ATRA-resistance in MR2 cells by using IFN-alpha and IFN-gamma in combination with all-trans retinoic acid (ATRA). Tretinoin 72-76 interferon gamma Homo sapiens 124-133 17319941-13 2007 Our findings suggest that loss of HLA class I induction in ESTDAB-004 cells results from a defect in the earliest steps of the IFN-gamma signaling pathway due to absence of STAT-1 tyrosine-phosphorylation, while absence of IFN-gamma-mediated HLA class I expression in ESTDAB-159 cells is due to epigenetic blocking of IFN-regulatory factor 1 (IRF-1) transactivation. Tyrosine 180-188 interferon gamma Homo sapiens 127-136 17277122-7 2007 Human immature dendritic cells (DCs) cultured in the presence of c-di-GMP showed increased expression of costimulatory molecules CD80/CD86 and maturation marker CD83, increased MHC class II and cytokines and chemokines such as IL-12, IFN-gamma, IL-8, MCP-1, IFN-gamma-inducible protein 10, and RANTES, and altered expression of chemokine receptors including CCR1, CCR7, and CXCR4. bis(3',5')-cyclic diguanylic acid 65-73 interferon gamma Homo sapiens 234-243 17266209-3 2007 We found that this isosteric replacement of alpha-GalCer"s amide moiety with triazole increases the IL-4 versus IFN-gamma bias of released cytokines. alpha-galactosylceramide 44-56 interferon gamma Homo sapiens 112-121 17277122-7 2007 Human immature dendritic cells (DCs) cultured in the presence of c-di-GMP showed increased expression of costimulatory molecules CD80/CD86 and maturation marker CD83, increased MHC class II and cytokines and chemokines such as IL-12, IFN-gamma, IL-8, MCP-1, IFN-gamma-inducible protein 10, and RANTES, and altered expression of chemokine receptors including CCR1, CCR7, and CXCR4. bis(3',5')-cyclic diguanylic acid 65-73 interferon gamma Homo sapiens 258-267 17266209-3 2007 We found that this isosteric replacement of alpha-GalCer"s amide moiety with triazole increases the IL-4 versus IFN-gamma bias of released cytokines. Amides 59-64 interferon gamma Homo sapiens 112-121 17266209-3 2007 We found that this isosteric replacement of alpha-GalCer"s amide moiety with triazole increases the IL-4 versus IFN-gamma bias of released cytokines. Triazoles 77-85 interferon gamma Homo sapiens 112-121 17110109-2 2007 The concentrations of cytokines (IFN-gamma, IL-12) were significantly increased in the presence of HL25 ([DMPC] = 100 microM, [C12(EO)25] = 10 microM) and the maximum values attained were 13-14 times higher compared with those of control, though the viability and proliferation of hPBMCs were decreased under the same conditions. Dimyristoylphosphatidylcholine 106-110 interferon gamma Homo sapiens 33-42 17023546-11 2007 Finally, we demonstrated that a reduction of Sp1 or NF-kappaB expression reduced CD98 protein expression in unstimulated and IFN-gamma-stimulated Caco2-BBE cells. caco2 146-151 interferon gamma Homo sapiens 125-134 17227295-5 2007 RESULTS: In group I, at time points C0 and C2, increased CsA-PK significantly inhibited expression of IL-2, IFN-gamma, PCNA and CD25 (P < 0.05). Cyclosporine 57-60 interferon gamma Homo sapiens 108-117 17283162-4 2007 Through this approach, it was found that 2-(1,8-naphthyridin-2-yl)phenol (2-NP) caused a 2-fold increase in STAT1-dependent reporter gene expression compared with that seen with maximally effective concentrations of IFN-gamma alone. 2-(1-,8-naphthyridin-2-yl)phenol 41-72 interferon gamma Homo sapiens 216-225 17283162-4 2007 Through this approach, it was found that 2-(1,8-naphthyridin-2-yl)phenol (2-NP) caused a 2-fold increase in STAT1-dependent reporter gene expression compared with that seen with maximally effective concentrations of IFN-gamma alone. 2-(1-,8-naphthyridin-2-yl)phenol 74-78 interferon gamma Homo sapiens 216-225 17283162-8 2007 2-NP increased the duration of STAT1 tyrosine phosphorylation in response to IFN-gamma, and this may underlie its enhancement of STAT1-dependent transcription. Tyrosine 37-45 interferon gamma Homo sapiens 77-86 17449270-4 2007 Further, exposure of IFNalpha-synchronized (at G0/G1) or mimosine-synchronized (at G1/S) WISH cells to IFNgamma, which was added at different time points post-release from the synchronizing agent, showed that the cells were promptly responsive to the growth inhibitory action of IFNgamma only during the first 11h in G1 phase. Mimosine 57-65 interferon gamma Homo sapiens 103-111 16650406-5 2007 We have analyzed the methylation status of the gene encoding the class II transactivator (CIITA), and asked whether treatment of class II MHC resistant ocular melanoma cells with the demethylating agent 5"-azacytidine can restore interferon-gamma inducibility of these class II MHC genes in these cells. Azacitidine 206-217 interferon gamma Homo sapiens 230-246 16889932-0 2007 Carbohydrate consumption during cycling increases in vitro NK cell responses to IL-2 and IFN-gamma. Carbohydrates 0-12 interferon gamma Homo sapiens 89-98 16889932-10 2007 Fold change in IL-2, IFN-gamma, and IL-2+IFN-gamma-stimulated NKCA were significantly greater in CHO compared to PLA (P<.05). CAV protocol 97-100 interferon gamma Homo sapiens 21-30 16889932-10 2007 Fold change in IL-2, IFN-gamma, and IL-2+IFN-gamma-stimulated NKCA were significantly greater in CHO compared to PLA (P<.05). CAV protocol 97-100 interferon gamma Homo sapiens 41-50 17158965-2 2007 IFNgamma, a key cytokine in TB, usually inhibits MMP-9 secretion. Terbium 28-30 interferon gamma Homo sapiens 0-8 17158965-3 2007 Addition of IFNgamma to conditioned media from M. tb-infected monocytes (CoMTB) resulted in a 7-fold increase in MMP-9 activity detected by gelatin zymography (P<0.01). Terbium 50-52 interferon gamma Homo sapiens 12-20 16650406-7 2007 Treatment with 5" azacytidine restores the ability of these cells to express class II MHC genes upon interferon-gamma treatment. Azacitidine 15-29 interferon gamma Homo sapiens 101-117 17095611-9 2007 This was in contrast to IFN-gamma, which as expected, increased the secretion of H(2)O(2) by approximately fourfold. Hydrogen Peroxide 81-89 interferon gamma Homo sapiens 24-33 17237409-8 2007 However, tyrosine phosphorylation of JAK-2 is compromised in IFN-gamma-treated choriocarcinoma cells. Tyrosine 9-17 interferon gamma Homo sapiens 61-70 17237409-9 2007 Moreover, phosphorylation of STAT-1 at tyrosine 701 is substantially reduced in both IFN-gamma-treated human choriocarcinoma and primary TBCs compared with HeLa cells or primary foreskin fibroblasts. Tyrosine 39-47 interferon gamma Homo sapiens 85-94 17237409-11 2007 Treatment of choriocarcinoma cells with the tyrosine phosphatase inhibitor pervanadate significantly enhanced IFN-gamma-inducible JAK and STAT-1 tyrosine phosphorylation and select IFN-gamma-inducible gene expression. pervanadate 75-86 interferon gamma Homo sapiens 110-119 17237409-11 2007 Treatment of choriocarcinoma cells with the tyrosine phosphatase inhibitor pervanadate significantly enhanced IFN-gamma-inducible JAK and STAT-1 tyrosine phosphorylation and select IFN-gamma-inducible gene expression. pervanadate 75-86 interferon gamma Homo sapiens 181-190 17237409-11 2007 Treatment of choriocarcinoma cells with the tyrosine phosphatase inhibitor pervanadate significantly enhanced IFN-gamma-inducible JAK and STAT-1 tyrosine phosphorylation and select IFN-gamma-inducible gene expression. Tyrosine 44-52 interferon gamma Homo sapiens 110-119 17237409-11 2007 Treatment of choriocarcinoma cells with the tyrosine phosphatase inhibitor pervanadate significantly enhanced IFN-gamma-inducible JAK and STAT-1 tyrosine phosphorylation and select IFN-gamma-inducible gene expression. Tyrosine 44-52 interferon gamma Homo sapiens 181-190 17108260-8 2007 Finally, trichostatin A, an HDAC inhibitor, prevents IFNgamma inhibitory action on TNFalpha-induced gene expression. trichostatin A 9-23 interferon gamma Homo sapiens 53-61 17079650-6 2007 These thimerosal-exposed DC induced increased TH2 (IL-5 and IL-13) and decreased TH1 (IFN-gamma) cytokine secretion from the T cells in the absence of additional thimerosal added to the coculture. Thimerosal 6-16 interferon gamma Homo sapiens 86-95 17079650-7 2007 Thimerosal exposure of DC led to the depletion of intracellular glutathione (GSH), and addition of exogenous GSH to DC abolished the TH2-promoting effect of thimerosal-treated DC, restoring secretion of TNF-alpha, IL-6, and IL-12p70 by DC and IFN-gamma secretion by T cells. Thimerosal 0-10 interferon gamma Homo sapiens 243-252 17079650-7 2007 Thimerosal exposure of DC led to the depletion of intracellular glutathione (GSH), and addition of exogenous GSH to DC abolished the TH2-promoting effect of thimerosal-treated DC, restoring secretion of TNF-alpha, IL-6, and IL-12p70 by DC and IFN-gamma secretion by T cells. Glutathione 109-112 interferon gamma Homo sapiens 243-252 17079650-7 2007 Thimerosal exposure of DC led to the depletion of intracellular glutathione (GSH), and addition of exogenous GSH to DC abolished the TH2-promoting effect of thimerosal-treated DC, restoring secretion of TNF-alpha, IL-6, and IL-12p70 by DC and IFN-gamma secretion by T cells. Thimerosal 157-167 interferon gamma Homo sapiens 243-252 17174521-0 2007 Multiple seropathotypes of verotoxin-producing Escherichia coli (VTEC) disrupt interferon-gamma-induced tyrosine phosphorylation of signal transducer and activator of transcription (Stat)-1. Tyrosine 104-112 interferon gamma Homo sapiens 79-95 17121749-14 2007 In contrast, sHLA-G induced proliferation and IFN-gamma production by both uterine and peripheral natural killer (NK) cells. shla 13-17 interferon gamma Homo sapiens 46-55 17174521-1 2007 Verotoxin-producing Escherichia coli (VTEC) O157:H7 inhibits interferon-gamma-stimulated tyrosine phosphorylation of signal transducer and activator of transcription (Stat)-1 in epithelial cells, independent of Verotoxins and the locus of enterocyte effacement pathogenicity island. Tyrosine 89-97 interferon gamma Homo sapiens 61-77 17174521-13 2007 Inhibition of interferon-gamma stimulated Stat1-tyrosine phosphorylation by VTEC of multiple seropathotypes indicates the presence of a common inhibitory factor that is independent of bacterial virulence in humans. Tyrosine 48-56 interferon gamma Homo sapiens 14-30 16908190-5 2007 The resulting process used Butyl and Q-Sepharose, refolding and SP-Sepharose for purification of IFN-gamma. q-sepharose 37-48 interferon gamma Homo sapiens 97-106 16908190-5 2007 The resulting process used Butyl and Q-Sepharose, refolding and SP-Sepharose for purification of IFN-gamma. sp-sepharose 64-76 interferon gamma Homo sapiens 97-106 17490542-16 2007 Stat1-alpha antisense oligonucleotides may have a sequence-specific inhibiting effect on the expression of CIITA and HLA-DR antigen after IFN-gamma incubation in vitro culture, and can prevent T lymphocyte activation. Oligonucleotides 22-38 interferon gamma Homo sapiens 138-147 17286914-4 2007 The effects of TBP and TRBP on the functions of human monocytes activated by TNF-alpha and IFN-gamma in vitro were detected by nitrotetrazolium blue chloride (NBT) reduction assay for evaluating respiratory burst and by RT-PCR for evaluating IL-1beta and IL-8 mRNA transcription. trbp 23-27 interferon gamma Homo sapiens 91-100 17286914-4 2007 The effects of TBP and TRBP on the functions of human monocytes activated by TNF-alpha and IFN-gamma in vitro were detected by nitrotetrazolium blue chloride (NBT) reduction assay for evaluating respiratory burst and by RT-PCR for evaluating IL-1beta and IL-8 mRNA transcription. Nitroblue Tetrazolium 127-157 interferon gamma Homo sapiens 91-100 17286914-4 2007 The effects of TBP and TRBP on the functions of human monocytes activated by TNF-alpha and IFN-gamma in vitro were detected by nitrotetrazolium blue chloride (NBT) reduction assay for evaluating respiratory burst and by RT-PCR for evaluating IL-1beta and IL-8 mRNA transcription. Nitroblue Tetrazolium 159-162 interferon gamma Homo sapiens 91-100 17445473-10 2007 CONCLUSION: Rosiglitazone could regulate the balance of IFN-gamma and IL-4 through effect on the expression of T-bet mRNA and GATA-3 mRNA. Rosiglitazone 12-25 interferon gamma Homo sapiens 56-65 17286914-7 2007 The combination of TBP and TRBP was able to obviously inhibit both respiratory burst of monocytes induced by TNF-alpha and IFN-gamma and transcription level of IL-1beta and IL-8 mRNA induced by TNF-alpha. trbp 27-31 interferon gamma Homo sapiens 123-132 17342997-5 2007 Moreover, the ratios of T-bet/GATA-3 and IFN-gamma/IL-4 were higher in the CKZ groups than those in the blank group, respectively, though showing insignificant difference in the former (P > 0.05), the difference in the latter was certainly significant (P < 0.05). CHEMBL4169281 75-78 interferon gamma Homo sapiens 41-50 17107666-6 2007 Our results demonstrated that ATRA suppressed NF-kappaB activity and prevented IkappaBalpha degradation in a dose-dependent way, inhibited IFN-gamma production and gene expression of granzyme B and NKp46. Tretinoin 30-34 interferon gamma Homo sapiens 139-148 17569223-6 2007 Curcumin inhibits these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells. Curcumin 0-8 interferon gamma Homo sapiens 126-135 16985181-3 2007 Catecholamine release results in reduced production of interleukin-10 and transforming growth factor-beta by Tregs, and in down-regulation of Treg-dependent inhibition of effector T-lymphocyte (Teff) proliferation, which occurs without affecting the production of tumor necrosis factor-alpha or interferon-gamma. Catecholamines 0-13 interferon gamma Homo sapiens 295-311 17143825-9 2007 CD8+ T cell levels specific for each pool of peptides were similar in both groups, but cells mainly contributing to HIV Gag-specific responses in coinfected patients were CCL4 positive and interferon-gamma negative, whereas for HIV-monoinfected subjects, the response was dominated by CCL4-positive and interferon-gamma-positive cells. Glycosaminoglycans 120-123 interferon gamma Homo sapiens 189-205 16754651-6 2007 Carriers of the IFNgamma(+874)T allele required mechanical ventilation and oxygen supplementation for time periods 41% and 35%, respectively, shorter than those required by those not carrying the IFNgamma(+874)T allele. Oxygen 75-81 interferon gamma Homo sapiens 16-24 16778833-0 2007 Characterization of LPS and interferon-gamma triggered activation-induced cell death in N9 and primary microglial cells: induction of the mitochondrial gateway by nitric oxide. Nitric Oxide 163-175 interferon gamma Homo sapiens 28-44 17143825-9 2007 CD8+ T cell levels specific for each pool of peptides were similar in both groups, but cells mainly contributing to HIV Gag-specific responses in coinfected patients were CCL4 positive and interferon-gamma negative, whereas for HIV-monoinfected subjects, the response was dominated by CCL4-positive and interferon-gamma-positive cells. Glycosaminoglycans 120-123 interferon gamma Homo sapiens 303-319 17976310-0 2007 Differential diagnosis of gingival hyperplasia based on IFN-gamma-stimulated gene expression using oligonucleotide microarrays. Oligonucleotides 99-114 interferon gamma Homo sapiens 56-65 17969446-2 2007 The major signaling pathway activated by IFN-gamma involves sequential phosphorylation of the tyrosine residues of the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) proteins, providing the primary mechanism through which gene expression is induced. Tyrosine 94-102 interferon gamma Homo sapiens 41-50 17192467-4 2007 The response to IFN-gamma was countered by interleukin-4 and 1alpha-methyl Trp. Tryptophan 75-78 interferon gamma Homo sapiens 16-25 17146715-4 2007 Cells devoid of 9-O-acetylations (9-O-AcSA(-)) revealed decreased nitric oxide production as compared to 9-O-AcSA(+) cells on exposure to IFN-gamma. Nitric Oxide 66-78 interferon gamma Homo sapiens 138-147 18086377-0 2007 N(2)O(3) enhances the nitrosative potential of IFNgamma-primed macrophages in response to Salmonella. n(2)o(3) 0-8 interferon gamma Homo sapiens 47-55 18086377-4 2007 Hmp was found to prevent the formation of 300nM N(2)O(3)/h/bacteria in IFNgamma-primed macrophages, accounting for about a 60% reduction of the nitrosative power of activated phagocytes. n(2)o(3) 48-56 interferon gamma Homo sapiens 71-79 18086377-5 2007 Utilization of the vacuolar ATPase inhibitor bafilomycin indicates that a fourth of the approximately 200nM N(2)O(3)/h sustained by IFNgamma-primed macrophages is generated in endosomal compartments via condensation of HNO(2). bafilomycin 45-56 interferon gamma Homo sapiens 132-140 17057410-6 2007 CONCLUSION: Neopterin production and tryptophan degradation in monocyte-derived macrophages are both triggered by the pro-inflammatory cytokine interferon-gamma. Neopterin 12-21 interferon gamma Homo sapiens 144-160 17057410-6 2007 CONCLUSION: Neopterin production and tryptophan degradation in monocyte-derived macrophages are both triggered by the pro-inflammatory cytokine interferon-gamma. Tryptophan 37-47 interferon gamma Homo sapiens 144-160 17541287-5 2007 RESULTS: Allergen-induced IL-5, IL-13, and IFN-gamma production of PBMC were significantly suppressed by formoterol in a dose-dependent manner, whereas the proliferation response was not suppressed. Formoterol Fumarate 105-115 interferon gamma Homo sapiens 43-52 17241867-5 2007 RESULTS: The spontaneously low HIMEC FKN expression was enhanced markedly by tumor necrosis factor-alpha plus interferon-gamma stimulation, or direct leukocyte contact. 3-[2-Chloro-5-(Methylsulfonyl)phenyl]-6-(2,4-Difluorophenoxy)-1h-Pyrazolo[3,4-D]pyrimidine 37-40 interferon gamma Homo sapiens 110-126 17208589-10 2007 The reduction by IFN-gamma was partially restored by U0126, inhibitor for mitogen-activated protein kinase kinase 1/2, suggesting a role for extracellular signal-regulated kinase pathway. U 0126 53-58 interferon gamma Homo sapiens 17-26 17198087-8 2007 PTX significantly reduced the production of TNF-alpha and IFN-gamma in mature DCs (mDCs). Pentoxifylline 0-3 interferon gamma Homo sapiens 58-67 17198087-10 2007 Therefore, PTX significantly inhibits CD14+ monocyte-derived DC differentiation, maturation, antigen-uptake ability of iDCs, and antigen-presentation ability of mDCs possibly due to the suppression of TNF-alpha and IFN-gamma production. Pentoxifylline 11-14 interferon gamma Homo sapiens 215-224 17266440-0 2007 Jak inhibition, but not Stat1 knockdown, blocks the synergistic effect of IFN-gamma on Fas-induced apoptosis of A549 human non-small cell lung cancer cells. ammonium ferrous sulfate 87-90 interferon gamma Homo sapiens 74-83 17323859-5 2007 RESULTS: RT-PCR revealed that IL-12-induced expression of IFN-gamma was partially suppressed by loratadine and fexofenadine and that all 4 agents tested inhibited IL-4-induced expression of IL-5. Loratadine 96-106 interferon gamma Homo sapiens 58-67 17323859-5 2007 RESULTS: RT-PCR revealed that IL-12-induced expression of IFN-gamma was partially suppressed by loratadine and fexofenadine and that all 4 agents tested inhibited IL-4-induced expression of IL-5. fexofenadine 111-123 interferon gamma Homo sapiens 58-67 17323859-6 2007 ELISA demonstrated that IL-12-induced IFN-gamma production was significantly suppressed by cetirizine and fexofenadine and IL-4-induced IL-5 production was downregulated by three agents with the exception of cetirizine. Cetirizine 91-101 interferon gamma Homo sapiens 38-47 17323859-6 2007 ELISA demonstrated that IL-12-induced IFN-gamma production was significantly suppressed by cetirizine and fexofenadine and IL-4-induced IL-5 production was downregulated by three agents with the exception of cetirizine. fexofenadine 106-118 interferon gamma Homo sapiens 38-47 17895603-11 2007 Sophy beta-glucan also blocked the stimulator cell induction of DNA synthesis and IFN-gamma production in the responder cells in a one-way mixed lymphocyte reaction (MLR) using allogenic PBMCs. beta-Glucans 6-17 interferon gamma Homo sapiens 82-91 18084696-5 2007 Thus, LPS and poly-IC can upregulate TSLP via a NF-kappaB pathway in synovial fibroblasts, which is downregulated by dexamethasone and interferon (IFN)-gamma. Poly I-C 14-21 interferon gamma Homo sapiens 135-157 17136028-12 2007 Kyn/trp correlated significantly with neopterin suggesting an IFN-gamma-induced increase in IDO activity. Kynurenine 0-3 interferon gamma Homo sapiens 62-71 17136028-12 2007 Kyn/trp correlated significantly with neopterin suggesting an IFN-gamma-induced increase in IDO activity. Tryptophan 4-7 interferon gamma Homo sapiens 62-71 17136028-12 2007 Kyn/trp correlated significantly with neopterin suggesting an IFN-gamma-induced increase in IDO activity. Neopterin 38-47 interferon gamma Homo sapiens 62-71 17377406-4 2007 The aim of the study was to compare the in vitro effect of vitamin A on the production of pro-inflammatory (IL-1beta and IL-6) and anti-inflammatory (IL-1 receptor antagonist (ra) and IL-10) cytokines, as well as IL-2 and IFNgamma by cord blood mononuclear cells (CBMC) of preterm newborns to that of peripheral blood mononuclear cells (PBMC) from adults. Vitamin A 59-68 interferon gamma Homo sapiens 222-230 16516295-4 2007 Silencing of PKR expression by siRNA or inhibition of PKR by 2-aminopurine (2-AP) potently blocks the IFN-gamma-induced transcriptional activation of the FcgammaRI promoter. 2-Aminopurine 61-74 interferon gamma Homo sapiens 102-111 16516295-4 2007 Silencing of PKR expression by siRNA or inhibition of PKR by 2-aminopurine (2-AP) potently blocks the IFN-gamma-induced transcriptional activation of the FcgammaRI promoter. 2-Aminopurine 76-80 interferon gamma Homo sapiens 102-111 16516295-5 2007 We find that the serine 727 phosphorylation of Stat1, required for full IFN-gamma-induced FcgammaRI promoter activity, is dependent on PKR. Serine 17-23 interferon gamma Homo sapiens 72-81 16516295-7 2007 Our results suggest that IFN-gamma-induced increase of FcgammaRI expression requires the integration of two signalling events: PKR-dependent Stat1 serine 727 phosphorylation, and activation of NFkappaB. Serine 147-153 interferon gamma Homo sapiens 25-34 17377406-7 2007 RESULTS: Vitamin A exerted an in vitro inhibitory effect on the production of the anti-inflammatory cytokine IL-1ra by MC of preterm newborns and adults, but did not affect the secretion of the pro-inflammatory cytokines IL-1beta, IL-6 and IFNgamma. Vitamin A 9-18 interferon gamma Homo sapiens 240-248 18572508-0 2007 [Interferon alpha, gamma, omega before and during treatment of chronic hepatitis C with pegylated interferon alpha and ribavirin]. Ribavirin 119-128 interferon gamma Homo sapiens 1-31 17700036-11 2007 CONCLUSIONS: The current study shows that acute morphine administration reduces white blood cells" capability to induce protection against HSV-1 infection via suppression of IFN-gamma production and NK cells activity. Morphine 48-56 interferon gamma Homo sapiens 174-183 17294742-7 2007 IFN-gamma (300 U/ mL) stimulated ICAM-1 expression significantly, which was inhibited by DEX (10(-6) mol/L). Dexamethasone 89-92 interferon gamma Homo sapiens 0-9 18409353-6 2007 Both Th2/Tc2 (IL-4, IL-5, IL-13) and Th1/ Tc1 (IFNgamma) take their part in the development of contact allergy to nickel. Nickel 114-120 interferon gamma Homo sapiens 47-55 17294742-9 2007 DEX not only inhibits ICAM-1 expression, but also inhibits IFN-gamma-induced ICAM-1 expression on cultured OF in vitro. Dexamethasone 0-3 interferon gamma Homo sapiens 59-68 17294753-4 2007 The detection of NO in the culture solution that contained drugs (sulfated polysaccharides, Lentinan, Mannatide) was carried out by using interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) as positive control. polyactin A 102-111 interferon gamma Homo sapiens 138-154 17199961-7 2006 RESULTS: Combined medication of 10(-9) mol/L calcitriol and 100 ng/ml CsA inhibited human peripheral mononuclear cells" proliferation to alloantigen and the production of IL-2 and IFN-gamma but promoted that of IL-4 and IL-10. Calcitriol 45-55 interferon gamma Homo sapiens 180-189 17199961-7 2006 RESULTS: Combined medication of 10(-9) mol/L calcitriol and 100 ng/ml CsA inhibited human peripheral mononuclear cells" proliferation to alloantigen and the production of IL-2 and IFN-gamma but promoted that of IL-4 and IL-10. Cyclosporine 70-73 interferon gamma Homo sapiens 180-189 16902148-5 2006 Moreover, the efficacy of IVIg-mediated neutrophil killing was enhanced by the proinflammatory cytokines granulocyte/macrophage colony-stimulating factor (GM-CSF) and interferon-gamma (IFN-gamma), and this additional cell death required reactive oxygen species (ROSs) but not caspases. Reactive Oxygen Species 237-260 interferon gamma Homo sapiens 185-194 16902148-5 2006 Moreover, the efficacy of IVIg-mediated neutrophil killing was enhanced by the proinflammatory cytokines granulocyte/macrophage colony-stimulating factor (GM-CSF) and interferon-gamma (IFN-gamma), and this additional cell death required reactive oxygen species (ROSs) but not caspases. Reactive Oxygen Species 262-266 interferon gamma Homo sapiens 185-194 17166390-0 2006 [Regulatory expression of human interferon-gamma gene in murine bone marrow stromal cells by Tet-off system]. tetramethylenedisulfotetramine 93-96 interferon gamma Homo sapiens 32-48 16996735-1 2006 Many of these analogues effectively suppress nitric oxide (NO) production in RAW cells stimulated with interferon-gamma. Nitric Oxide 45-57 interferon gamma Homo sapiens 103-119 17142760-5 2006 Treatment of cells with leptomycin B, a specific inhibitor of CRM-1, completely inhibited IFN-gamma induction of HLA-A. leptomycin B 24-36 interferon gamma Homo sapiens 90-99 17142760-7 2006 Increased expression of HLA-A induced by IFN-gamma also requires protein methylation, as shown by the fact that treatment of SK-N-MC cells or HeLa cells with the PRMT1 inhibitor 5"-methyl-5"-thioadenosine abolished the cellular response to IFN-gamma. sk-n-mc 125-132 interferon gamma Homo sapiens 41-50 17142760-7 2006 Increased expression of HLA-A induced by IFN-gamma also requires protein methylation, as shown by the fact that treatment of SK-N-MC cells or HeLa cells with the PRMT1 inhibitor 5"-methyl-5"-thioadenosine abolished the cellular response to IFN-gamma. 5"-methyl-5"-thioadenosine 178-204 interferon gamma Homo sapiens 41-50 17142760-7 2006 Increased expression of HLA-A induced by IFN-gamma also requires protein methylation, as shown by the fact that treatment of SK-N-MC cells or HeLa cells with the PRMT1 inhibitor 5"-methyl-5"-thioadenosine abolished the cellular response to IFN-gamma. 5"-methyl-5"-thioadenosine 178-204 interferon gamma Homo sapiens 240-249 17166390-2 2006 This study was to investigate the regulatory expression of human interferon-gamma (IFNgamma) gene in murine bone marrow stromal cells (BMSCs) by Tet-off system. tetramethylenedisulfotetramine 145-148 interferon gamma Homo sapiens 65-81 17166390-2 2006 This study was to investigate the regulatory expression of human interferon-gamma (IFNgamma) gene in murine bone marrow stromal cells (BMSCs) by Tet-off system. tetramethylenedisulfotetramine 145-148 interferon gamma Homo sapiens 83-91 17166390-8 2006 Then, Tetracycline was added to the culture medium immediately after co-transfection in gradient concentration and 48 h after co-transfection to observe its effect on IFNgamma secretion. Tetracycline 6-18 interferon gamma Homo sapiens 167-175 17166390-12 2006 Increasing tetracycline decreased the secretion of IFNgamma in the first 48 h: 10-100 ng/ml tetracycline decreased the secretion to nearly 0. Tetracycline 11-23 interferon gamma Homo sapiens 51-59 17166390-12 2006 Increasing tetracycline decreased the secretion of IFNgamma in the first 48 h: 10-100 ng/ml tetracycline decreased the secretion to nearly 0. Tetracycline 92-104 interferon gamma Homo sapiens 51-59 17166390-14 2006 CONCLUSION: The Tet-off system can efficiently and rapidly down-regulate the expression of human IFNgamma gene in murine BMSCs. tetramethylenedisulfotetramine 16-19 interferon gamma Homo sapiens 97-105 17035093-4 2006 This cell subset also expressed TNF-alpha and IFN-gamma, under phorbol-myristate-acetate/ionomycin stimulation. Tetradecanoylphorbol Acetate 63-88 interferon gamma Homo sapiens 46-55 17425177-2 2006 The objective of the present study was to analyze the serum concentration of IFN-gamma and IL-10 in anemic and non anemic children according to vitamin A nutritional status. Vitamin A 144-153 interferon gamma Homo sapiens 77-86 17425177-9 2006 The anemic children with VAD showed significant serum values of IFN-gamma e IL-10 lower than in other groups. VAD I protocol 25-28 interferon gamma Homo sapiens 64-73 17142800-3 2006 HYPOTHESES: 1) uNK cells are a major source of IFN gamma (IFN-gamma) and 2) IFN-gamma inhibits EVT invasion via an increase in EVT apoptosis and/or a decrease in active protease levels. EVT 95-98 interferon gamma Homo sapiens 47-74 17035093-4 2006 This cell subset also expressed TNF-alpha and IFN-gamma, under phorbol-myristate-acetate/ionomycin stimulation. Ionomycin 89-98 interferon gamma Homo sapiens 46-55 17142800-6 2006 EVT invasion in the presence of IFN-gamma or anti-IFN-gamma-neutralizing antibodies was assessed. EVT 0-3 interferon gamma Homo sapiens 32-41 17142800-6 2006 EVT invasion in the presence of IFN-gamma or anti-IFN-gamma-neutralizing antibodies was assessed. EVT 0-3 interferon gamma Homo sapiens 50-59 17142800-11 2006 The level of M30-positive EVT was increased in the presence of IFN-gamma whereas levels of secreted MMP2 were decreased. EVT 26-29 interferon gamma Homo sapiens 63-72 17142800-13 2006 Mechanisms of IFN-gamma inhibition of EVT invasion include both increased EVT apoptosis and reduced levels of active proteases. EVT 38-41 interferon gamma Homo sapiens 14-23 17142800-13 2006 Mechanisms of IFN-gamma inhibition of EVT invasion include both increased EVT apoptosis and reduced levels of active proteases. EVT 74-77 interferon gamma Homo sapiens 14-23 17238833-10 2006 The iNOS inhibitor, L-NAME, sensitized HuH7 to IFN-gamma, Hep3B/HuH7 coculture partially inhibited Hep3B apoptosis, and HuH7 transfection with iNOS siRNA induced a 50% inhibition of iNOS protein and cell apoptosis. NG-Nitroarginine Methyl Ester 20-26 interferon gamma Homo sapiens 47-56 17030574-1 2006 Gamma interferon (IFN-gamma)-induced indoleamine dioxygenase (IDO), which inhibits chlamydial replication by reducing the availability of tryptophan, is up-regulated by interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha). Tryptophan 138-148 interferon gamma Homo sapiens 18-27 16966384-4 2006 In the present study, we found that nicotine inhibited the IL-18-enhanced expression of ICAM-1, B7.2, and CD40 on monocytes, and the production of IL-12, IFN-gamma, and TNF-alpha by PBMC. Nicotine 36-44 interferon gamma Homo sapiens 154-163 17238806-7 2006 Glucosamine sulfate effectively downregulated the production of ICAM-1 induced by TNF-alpha, IFN-gamma, IL-1beta, TNF-alpha plus IFN-gamma, or TNF-alpha plus IL-1beta. Glucosamine 0-19 interferon gamma Homo sapiens 93-102 17238806-7 2006 Glucosamine sulfate effectively downregulated the production of ICAM-1 induced by TNF-alpha, IFN-gamma, IL-1beta, TNF-alpha plus IFN-gamma, or TNF-alpha plus IL-1beta. Glucosamine 0-19 interferon gamma Homo sapiens 129-138 17238806-9 2006 Glucosamine sulfate further inhibited the nuclear translocation of p65 protein in TNF-alpha- and IL-1beta-stimulated Chang conjunctival cells and phosphorylated STAT1 in IFN-gamma-stimulated Chang conjunctival cells. Glucosamine 0-19 interferon gamma Homo sapiens 170-179 17238806-10 2006 Glucosamine sulfate also significantly reduced the number of neutrophils adhering to a conjunctival monolayer in response to TNF-alpha, IFN-gamma, or IL-1beta. Glucosamine 0-19 interferon gamma Homo sapiens 136-145 17121582-3 2006 In the present study, the methylation status of six CpG sites in the proximal promoter of the human IFNgamma gene was determined by bisulphite sequencing. hydrogen sulfite 132-142 interferon gamma Homo sapiens 100-108 16963620-4 2006 The addition of a second dose of salicylate 4 h before an indicated endpoint suppressed C-Rel but not C/EBPbeta or interferon-gamma-regulated factor-1 binding at 8 and 24 h. A single dose of salicylate added with LPS/IFNgamma inhibited NOS-2 expression only at 4 h. However, salicylate supplement inhibited NOS-2 promoter activities and mRNA and protein levels throughout 24 h. Signal profiling with a panel of inhibitors revealed time-dependent switch of signaling pathways. Salicylates 33-43 interferon gamma Homo sapiens 217-225 17253943-8 2006 DCs matured in the presence of both LPA and LPS enhanced the production of interferon-gamma (IFN-gamma) when co-cultured with allogeneic T cells, compared with DC matured by LPS alone. lysophosphatidic acid 36-39 interferon gamma Homo sapiens 75-91 17228731-2 2006 Co-immobilize the photoactive IFN-gamma and TNF-alpha on the polystyrene membrane; Cultivate the Hela cell on the cell culture polystyrene plate surface and set up the cultivation of the photo-immobilization IFN-gamma+TNF-alpha, Photo-immobilization IFN-gamma, nature (IFN-gamma, TNF-alpha, IFN-gamma+TNF-alpha). Polystyrenes 61-72 interferon gamma Homo sapiens 30-39 17253943-8 2006 DCs matured in the presence of both LPA and LPS enhanced the production of interferon-gamma (IFN-gamma) when co-cultured with allogeneic T cells, compared with DC matured by LPS alone. lysophosphatidic acid 36-39 interferon gamma Homo sapiens 93-102 17253943-9 2006 Similar results were found using a model of allogeneic naive T cell differentiation, where LPA- plus LPS-matured DC enhanced IFN-gamma as well as IL-4 secretion after restimulation. lysophosphatidic acid 91-94 interferon gamma Homo sapiens 125-134 17204188-3 2006 The results showed that thalidomide enhanced the proliferations of the CD8+ T, NK cells in PHA-stimulated PBMNC from healthy volunteers, increased the secretion of IL-6 significantly, and decreased the secretion of IFN-gamma, and the secretions of IL-2 and IL-10 were not affected. Thalidomide 24-35 interferon gamma Homo sapiens 215-224 16889876-0 2006 Interferon-gamma dose-dependently inhibits prostaglandin E2-mediated dendritic-cell-migration towards secondary lymphoid organ chemokines. Dinoprostone 43-59 interferon gamma Homo sapiens 0-16 16889876-5 2006 Addition of IFN-gamma to PGE(2)-containing maturation cocktails has been shown to prime for substantial production of IL-12 p70 by subsequent CD40 ligation, but the impact of IFN-gamma on phenotypic maturation and migratory responsiveness induced by PGE(2)-containing inflammatory stimuli still remains elusive. Dinoprostone 25-31 interferon gamma Homo sapiens 12-21 16889876-5 2006 Addition of IFN-gamma to PGE(2)-containing maturation cocktails has been shown to prime for substantial production of IL-12 p70 by subsequent CD40 ligation, but the impact of IFN-gamma on phenotypic maturation and migratory responsiveness induced by PGE(2)-containing inflammatory stimuli still remains elusive. Prostaglandins E 25-29 interferon gamma Homo sapiens 12-21 16928387-4 2006 We also investigated the effects of Paeonol in colon cancer-derived CW-2 cells and T cell leukemia-derived Jurkat cells treated with tumor necrosis factor alpha (TNFalpha) and/or interferon gamma (IFNgamma), which play critical roles in TNBS-induced colitis. paeonol 36-43 interferon gamma Homo sapiens 179-206 16928387-7 2006 In CW-2 cells, Paeonol inhibited iNOS protein and mRNA expression induced by costimulation of TNFalpha and IFNgamma. paeonol 15-22 interferon gamma Homo sapiens 107-115 16928387-8 2006 Furthermore, Paeonol reduced TNFalpha-induced NF-kappaB transactivation and IFNgamma-induced STAT1 transactivation in CW-2 cells and also in Jurkat cells. paeonol 13-20 interferon gamma Homo sapiens 76-84 17073444-1 2006 Heparan sulfate (HS) recognizes a variety of proteins, one of which is the pleiotropic cytokine IFN-gamma, and as such modulates many biological processes. Heparitin Sulfate 0-15 interferon gamma Homo sapiens 96-105 17073444-1 2006 Heparan sulfate (HS) recognizes a variety of proteins, one of which is the pleiotropic cytokine IFN-gamma, and as such modulates many biological processes. Heparitin Sulfate 17-19 interferon gamma Homo sapiens 96-105 17073444-2 2006 IFN-gamma is a homodimer with a well-defined core and two flexible C-termini that constitute HS binding domains. Heparitin Sulfate 93-95 interferon gamma Homo sapiens 0-9 17073444-3 2006 We show here using molecular modeling that an extended IFN-gamma structure overlaps a HS fragment of 16 disaccharides (16 nm). Disaccharides 104-117 interferon gamma Homo sapiens 55-64 17073444-4 2006 Since a 21-24-disaccharide HS fragment was experimentally defined as the minimum size that interacts with IFN-gamma [Lortat-Jacob, H., Turnbull, J. E., and Grimaud, J. 21-24-disaccharide 8-26 interferon gamma Homo sapiens 106-115 17073444-4 2006 Since a 21-24-disaccharide HS fragment was experimentally defined as the minimum size that interacts with IFN-gamma [Lortat-Jacob, H., Turnbull, J. E., and Grimaud, J. Heparitin Sulfate 27-29 interferon gamma Homo sapiens 106-115 17073444-10 2006 For oligosaccharides of 14 and 20 nm, two types of complexes are formed with one IFN-gamma and one or two heparin molecules. Oligosaccharides 4-20 interferon gamma Homo sapiens 81-90 17073444-10 2006 For oligosaccharides of 14 and 20 nm, two types of complexes are formed with one IFN-gamma and one or two heparin molecules. Heparin 106-113 interferon gamma Homo sapiens 81-90 16979124-5 2006 Furthermore, the sulfone derivatives 3 and 6 showed dramatically reduction in the ratio of IFN-gamma to IL-4 production from mitogen-stimulated spleen cells. Sulfones 17-24 interferon gamma Homo sapiens 91-100 16786194-0 2006 TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate. ferrous sulfate 150-155 interferon gamma Homo sapiens 11-20 16877747-3 2006 We found that CLA exerted apparently opposed activities in in vitro experiments, depending on its concentration: 100 microM CLA downregulated IFN gamma synthesis and cell proliferation of splenocytes, in association with apoptosis induction and a decrease of intracellular thiols (GSH + GSSG), whereas 25 microM CLA did not significantly influence cell proliferation but enhanced the expression of gamma-glutamylcysteine ligase catalytic subunit (GCLC) and intracellular GSH concentration. Linoleic Acids, Conjugated 14-17 interferon gamma Homo sapiens 142-151 16877747-3 2006 We found that CLA exerted apparently opposed activities in in vitro experiments, depending on its concentration: 100 microM CLA downregulated IFN gamma synthesis and cell proliferation of splenocytes, in association with apoptosis induction and a decrease of intracellular thiols (GSH + GSSG), whereas 25 microM CLA did not significantly influence cell proliferation but enhanced the expression of gamma-glutamylcysteine ligase catalytic subunit (GCLC) and intracellular GSH concentration. Linoleic Acids, Conjugated 124-127 interferon gamma Homo sapiens 142-151 17301930-2 2006 Neopterin (NPT) is synthesised by human macrophages upon stimulation with interferon-gamma and is also capable of enhancing the oxidative potential of reactive oxygen species. Neopterin 0-9 interferon gamma Homo sapiens 74-90 17301930-2 2006 Neopterin (NPT) is synthesised by human macrophages upon stimulation with interferon-gamma and is also capable of enhancing the oxidative potential of reactive oxygen species. Neopterin 11-14 interferon gamma Homo sapiens 74-90 17071860-8 2006 Unlike BMMSCs, PDMCs treated with interferon-gamma for 3 days only very minimally upregulated HLA-DR. On the contrary, PD-L1, a cell surface marker that plays an inhibitory role in T-cell activation, was upregulated and TGF-beta expression was seen. pdmcs 15-20 interferon gamma Homo sapiens 34-50 17032249-4 2006 Interestingly, upon T. cruzi antigen in vitro stimulation, E-IND CD8+ lymphocytes displayed a selective enhancement of IFN-gamma expression, accounting for a global type 1-modulated cytokine microenvironment. e-ind 59-64 interferon gamma Homo sapiens 119-128 17032197-5 2006 RESULTS: Our data revealed that both MUC4 and IFNgamma were expressed at moderate to high levels in the majority of PA, while being undetectable in NP. Protactinium 116-118 interferon gamma Homo sapiens 46-54 17177332-5 2006 RESULT: SDS-PAGE and Western blot confirmed that gp120 N and gp120 N/IFN-gamma fusion proteins were successfully expressed. Sodium Dodecyl Sulfate 8-11 interferon gamma Homo sapiens 61-78 17177332-7 2006 And the response of gp120 N/IFN-gamma group was stronger than that of gp120 N group, the latter was stronger than that of PBS group (P < 0.05). Lead 122-125 interferon gamma Homo sapiens 20-37 17085967-5 2006 To investigate the effect of HDAC on transcription of an IFNgamma-activated gene, real-time PCR was used to measure CXCL10 mRNA in Hela cells stimulated with IFNgamma in the presence or absence of the HDAC inhibitor TSA. trichostatin A 216-219 interferon gamma Homo sapiens 57-65 17015708-5 2006 Surprisingly, the cytokine production of iNKT cells stimulated by alpha-galactosylceramide presented by CD1d+ Schwann cells showed a predominance of Th2-associated cytokines such as IL-5 and IL-13 with a marked deficiency of proinflammatory Th1 cytokines such as IFN-gamma or TNF-alpha. alpha-galactosylceramide 66-90 interferon gamma Homo sapiens 263-272 16970942-4 2006 We discovered that interferon-gamma (IFN-gamma) induced robust peroxidase activity in TBE cells that paralleled Duox2 expression. tbe 86-89 interferon gamma Homo sapiens 19-46 17069100-10 2006 The percentage of IFN-gamma+ NK cells increased after 3 weeks (P = .03) and 3 months (P = .01) of RIT. Ritonavir 98-101 interferon gamma Homo sapiens 18-27 17015954-2 2006 In this study, we investigated the change in Ca2+-ATPase activities and ATP levels in the human lens epithelial cell line SRA 01/04 (HLE cells) with the stimulation of interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). Adenosine Triphosphate 50-53 interferon gamma Homo sapiens 168-184 17015954-2 2006 In this study, we investigated the change in Ca2+-ATPase activities and ATP levels in the human lens epithelial cell line SRA 01/04 (HLE cells) with the stimulation of interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). Adenosine Triphosphate 50-53 interferon gamma Homo sapiens 186-195 17015954-5 2006 Ca2+-ATPase activities increased and ATP levels decreased in HLE cells stimulated with the combination of IFN-gamma and LPS. Adenosine Triphosphate 5-8 interferon gamma Homo sapiens 106-115 16838393-0 2006 Serum levels of the interferon-gamma-inducible alpha chemokine CXCL10 in patients with active Graves" disease, and modulation by methimazole therapy and thyroidectomy. Methimazole 129-140 interferon gamma Homo sapiens 20-36 17161616-11 2006 Several pro-inflammatory/resorptive cytokines including IL-6, IL-4, IFN-gamma, macrophage inhibitory factor (MIF) were down-regulated not only by DEX but also by DHEA. Dexamethasone 146-149 interferon gamma Homo sapiens 68-77 17166736-5 2006 In PMA/ionomycin stimulated cells, pre-incubated with increasing concentrations of NIV, transcription was induced in the range 0.06-2 microM; higher concentrations of NIV were found non-stimulating (4 microM) or inhibitory (8 microM) for IFNgamma and IL-2 whereas IL-8 was still induced. Ionomycin 7-16 interferon gamma Homo sapiens 238-246 17166736-6 2006 DON administration elicited a similar profile for IL-8 and IFNgamma, whilst IL-2 mRNA was induced in a broader range of concentrations. deoxynivalenol 0-3 interferon gamma Homo sapiens 59-67 17161616-11 2006 Several pro-inflammatory/resorptive cytokines including IL-6, IL-4, IFN-gamma, macrophage inhibitory factor (MIF) were down-regulated not only by DEX but also by DHEA. Dehydroepiandrosterone 162-166 interferon gamma Homo sapiens 68-77 16388933-6 2006 The fact that trimipramine also suppressed IFN-gamma production and T-cell proliferation indicates that these immunomodulatory actions of antidepressants are most likely unrelated to inhibition of monoamine reuptake. Trimipramine 14-26 interferon gamma Homo sapiens 43-52 17008485-0 2006 Whole blood IFN-gamma assay for detecting TB in children. Terbium 42-44 interferon gamma Homo sapiens 12-21 16968468-7 2006 In contrast, ciprofloxacin significantly (P < 0.001) inhibited the pro-inflammatory cytokines (interleukin-1alpha + tumour necrosis factor-alpha + interferon-gamma)-induced NO production in HT-29, in a concentration-dependent manner, via the inhibition of the cytokine-induced iNOS mRNA expression. Ciprofloxacin 13-26 interferon gamma Homo sapiens 150-166 16988134-8 2006 Interferon-gamma produced by phorbol-stimulated lymphocytes was reduced 70% in the FVJC group, whereas other cytokines (IL-4, IL-6, transforming growth factor beta) were unchanged relative to treatment or time. phorbol 29-36 interferon gamma Homo sapiens 0-16 17152936-3 2006 In addition, LmSEAgs stimulated human peripheral blood mononuclear cells to produce large amounts of interferon-gamma and some interleukin-5. lmseags 13-20 interferon gamma Homo sapiens 101-117 17042679-3 2006 In this study, we examine the effects of the glucocorticoid, dexamethasone, and the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligand, rosiglitazone on the expression of interferon (IFN)-gamma (T(H)1) and interleukin (IL)-4 (T(H)2) by activated peripheral CD4(+) and CD8(+) lymphocytes in patients with HT (n = 10) and healthy control subjects (n = 12). Dexamethasone 61-74 interferon gamma Homo sapiens 189-211 17042679-3 2006 In this study, we examine the effects of the glucocorticoid, dexamethasone, and the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligand, rosiglitazone on the expression of interferon (IFN)-gamma (T(H)1) and interleukin (IL)-4 (T(H)2) by activated peripheral CD4(+) and CD8(+) lymphocytes in patients with HT (n = 10) and healthy control subjects (n = 12). Rosiglitazone 154-167 interferon gamma Homo sapiens 189-211 17042679-7 2006 A dose-dependent inhibition of IFN-gamma expression was seen with dexamethasone and rosiglitazone. Dexamethasone 66-79 interferon gamma Homo sapiens 31-40 17042679-7 2006 A dose-dependent inhibition of IFN-gamma expression was seen with dexamethasone and rosiglitazone. Rosiglitazone 84-97 interferon gamma Homo sapiens 31-40 17042679-8 2006 Inhibition of CD4(+) and CD8(+) IFN-gamma expression with both dexamethasone and rosiglitazone was greater in control subjects than in patients (p < 0.05). Dexamethasone 63-76 interferon gamma Homo sapiens 32-41 17042679-8 2006 Inhibition of CD4(+) and CD8(+) IFN-gamma expression with both dexamethasone and rosiglitazone was greater in control subjects than in patients (p < 0.05). Rosiglitazone 81-94 interferon gamma Homo sapiens 32-41 17052394-6 2006 The level of IFN-gamma and the ratio of IFN-gamma/IL-4 in the RT-AM group were markedly higher than those in the RT-PHA group (P < 0.01), but were significantly lower than those in the Control group (P < 0.05). rt 62-64 interferon gamma Homo sapiens 13-22 17052394-6 2006 The level of IFN-gamma and the ratio of IFN-gamma/IL-4 in the RT-AM group were markedly higher than those in the RT-PHA group (P < 0.01), but were significantly lower than those in the Control group (P < 0.05). rt 62-64 interferon gamma Homo sapiens 40-49 16873363-0 2006 Transient kinetic investigation of GTP hydrolysis catalyzed by interferon-gamma-induced hGBP1 (human guanylate binding protein 1). Guanosine Triphosphate 35-38 interferon gamma Homo sapiens 63-79 16940188-1 2006 BACKGROUND: Heparin, used clinically as an anticoagulant, also has antiinflammatory properties and has been described to inhibit interferon (IFN)-gamma responses in endothelial cells. Heparin 12-19 interferon gamma Homo sapiens 129-151 16940188-2 2006 We investigated the effects of heparin on the IFN-gamma-inducible chemokines IP-10/CXCL10, I-TAC/CXCL11, and Mig/CXCL9, which play important roles in the vascular recruitment of IFN-gamma-producing Th1 cells through interactions with their cognate receptor, CXCR3. Heparin 31-38 interferon gamma Homo sapiens 46-55 16940188-6 2006 We confirmed previous reports that heparin inhibits the IFN-gamma-dependent production of CXCR3 chemokine ligands using atherosclerotic coronary arteries in organ culture. Heparin 35-42 interferon gamma Homo sapiens 56-65 16940188-9 2006 CONCLUSIONS: Besides inhibiting IFN-gamma responses, heparin has further immunomodulatory effects by competing for binding with IP-10, I-TAC, and Mig on endothelial cells. Heparin 53-60 interferon gamma Homo sapiens 32-41 16951314-7 2006 Furthermore, dexamethasone inhibits bryostatin-1-induced IFN-gamma mRNA expression but increases bryostatin-1-induced T-bet mRNA expression. Dexamethasone 13-26 interferon gamma Homo sapiens 57-66 16951314-10 2006 In summary, our results suggest that bryostatin-1-induced IFN-gamma expression is T-bet independent. bryostatin 1 37-49 interferon gamma Homo sapiens 58-67 16611657-6 2006 In the intent-to-treat population, five out of 32 (15.6%) IFN-gamma-1b patients and seven out of 18 (38.8%) colchicine patients died after a median follow-up period of 25 months Patients treated with IFN-gamma 1b showed a better outcome after 2 yrs of therapy, and fewer symptoms, as assessed using the St George"s Respiratory Questionnaire, after 12 months of therapy. Colchicine 108-118 interferon gamma Homo sapiens 200-209 16951345-2 2006 We showed that z-FA-FMK suppresses the secretion of IL-2 and IFN-gamma as well as the expression of IL-2R alpha-chain (CD25) in activated T cells, whereas the expression of the early activated T cell marker, CD69, was unaffected. MDL 201053 15-23 interferon gamma Homo sapiens 61-70 16951350-6 2006 Exposure of beryllium-specific CD4+ T cells to BeSO4 -pulsed, plate-bound rHLA-DP2 molecules induced IFN-gamma secretion. Beryllium 12-21 interferon gamma Homo sapiens 101-110 16951350-6 2006 Exposure of beryllium-specific CD4+ T cells to BeSO4 -pulsed, plate-bound rHLA-DP2 molecules induced IFN-gamma secretion. beryllium sulfate 47-52 interferon gamma Homo sapiens 101-110 16952544-6 2006 LPMCs from symptomatic CVID patients produced significantly higher T-helper (Th) 1 cytokines, interleukin-12, and interferon-gamma. lpmcs 0-5 interferon gamma Homo sapiens 114-130 16762028-7 2006 Although both virus-stimulated PDCs and LPS-stimulated MDCs preferentially induced the development of interferon-gamma-producing Th1 cells, pretreatment with PGE2 led both DC subsets to attenuate their Th1-inducing capacity. Dinoprostone 158-162 interferon gamma Homo sapiens 102-118 17147054-3 2006 Exposure to IFN-gamma greatly enhances the microbicidal (and, to a lesser degree, citotoxic) activity of macrophages and induces them to secrete nitric oxide and monokines such as IL-1, IL-6, IL-8, and TFNalpha. Nitric Oxide 145-157 interferon gamma Homo sapiens 12-21 16787983-1 2006 CONTEXT: 25-Hydroxyvitamin D can be activated to 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] by the rate-limiting enzyme 1alpha-hydroxylase in cells of the immune system under control of immune stimuli, such as interferon-gamma (IFNgamma). 25-hydroxyvitamin D 9-28 interferon gamma Homo sapiens 212-228 16950283-13 2006 However, dexamethasone potentiated TLR2 expression induced by combined IFN-gamma and TNF-alpha stimulation. Dexamethasone 9-22 interferon gamma Homo sapiens 71-80 16787983-1 2006 CONTEXT: 25-Hydroxyvitamin D can be activated to 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] by the rate-limiting enzyme 1alpha-hydroxylase in cells of the immune system under control of immune stimuli, such as interferon-gamma (IFNgamma). 25-hydroxyvitamin D 9-28 interferon gamma Homo sapiens 230-238 16787983-1 2006 CONTEXT: 25-Hydroxyvitamin D can be activated to 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] by the rate-limiting enzyme 1alpha-hydroxylase in cells of the immune system under control of immune stimuli, such as interferon-gamma (IFNgamma). 1,25-dihydroxyvitamin D 49-72 interferon gamma Homo sapiens 212-228 16787983-1 2006 CONTEXT: 25-Hydroxyvitamin D can be activated to 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] by the rate-limiting enzyme 1alpha-hydroxylase in cells of the immune system under control of immune stimuli, such as interferon-gamma (IFNgamma). 1,25-dihydroxyvitamin D 49-72 interferon gamma Homo sapiens 230-238 16787983-8 2006 In contrast, in phorbol myristate acetate-differentiated THP1 macrophages, IFNgamma alone induces 1alpha-hydroxylase and to much higher levels. Tetradecanoylphorbol Acetate 16-41 interferon gamma Homo sapiens 75-83 16920991-5 2006 We found that imatinib-treated CML-chronic phase patients showing a complete cytogenetic response had NKT cells capable of producing IFN-gamma, whereas NKT cells from patients who were only partially responsive to imatinib treatment did not produce IFN-gamma. Imatinib Mesylate 14-22 interferon gamma Homo sapiens 133-142 16920991-5 2006 We found that imatinib-treated CML-chronic phase patients showing a complete cytogenetic response had NKT cells capable of producing IFN-gamma, whereas NKT cells from patients who were only partially responsive to imatinib treatment did not produce IFN-gamma. Imatinib Mesylate 14-22 interferon gamma Homo sapiens 249-258 16971807-4 2006 These cells not only express and secrete the HIV p24 antigen after electroporation with codon-optimized HIV-1 gag mRNA, but can also be used to in vitro reactivate Gag antigen-specific interferon-gamma-producing CD4 and CD8 autologous T-cells. Glycosaminoglycans 164-167 interferon gamma Homo sapiens 185-201 16870268-3 2006 Simvastatin, the statin with the strongest antiproliferative effect, inhibited IFN-gamma-induced expression of MHC class II DR on monocytes and decreased their antigen presenting capacity. Simvastatin 0-11 interferon gamma Homo sapiens 79-88 16870268-5 2006 Simvastatin inhibited IFN-gamma, TNF-alpha, and IL-2 secretion, as well as the expression of T-bet, a transcription factor that regulates Th1 cell differentiation. Simvastatin 0-11 interferon gamma Homo sapiens 22-31 16442319-5 2006 Inhibition of leptin secretion that had been induced by the IFN-gamma-LPS mixture was completely nullified by NOS inhibitors such as Nomega-monomethyl-L-arginine and aminoguanidine. omega-N-Methylarginine 133-161 interferon gamma Homo sapiens 60-69 16413058-1 2006 OBJECTIVE: Neopterin is generated and released in increased amounts by macrophages upon activation by interferon-gamma during Th1-type immune response. Neopterin 11-20 interferon gamma Homo sapiens 102-118 16442319-5 2006 Inhibition of leptin secretion that had been induced by the IFN-gamma-LPS mixture was completely nullified by NOS inhibitors such as Nomega-monomethyl-L-arginine and aminoguanidine. pimagedine 166-180 interferon gamma Homo sapiens 60-69 16939878-7 2006 In conclusion, 15 PGJ2 inhibits strongly and specifically the IFNgamma-induced MHC class II expression on RPE cells by a PPARgamma independent mechanism. 9-deoxy-delta-9-prostaglandin D2 18-22 interferon gamma Homo sapiens 62-70 16775808-0 2006 CKBM stimulates MAPKs but inhibits LPS-induced IFN-gamma in lymphocytes. ckbm 0-4 interferon gamma Homo sapiens 47-56 16775808-6 2006 In terms of cytokine production, treatment of CKBM alone did not trigger the release of IL-1beta and IFNgamma, but it suppressed the LPS-induced IFNgamma production from both Sup-T1 cells and Ramos cells. ckbm 46-50 interferon gamma Homo sapiens 145-153 16790487-9 2006 Further computational and biochemical analyses show that cyfluthrin and chlorpyrifos upregulate certain targets of the interferon-gamma and insulin-signaling pathways and that they increase the protein levels of activated extracellular signal-regulated kinase 1/2, a key component of insulin signaling; interleukin 6, a key inflammatory mediator; and glial fibrillary acidic protein, a marker of inflammatory astrocyte activation. Chlorpyrifos 72-84 interferon gamma Homo sapiens 119-135 16939878-0 2006 15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. 15-deoxy-delta(12,14)-prostaglandin J2 0-31 interferon gamma Homo sapiens 41-57 16939878-2 2006 In the present work, we investigated the effects of 15-deoxy-12,14-prostaglandin J2 (15 PGJ2), an endogenous ligand of PPARgamma, on the IFNgamma-induced expression of MHC class II on RPE cells. 15-deoxy-delta(12,14)-prostaglandin J2 52-83 interferon gamma Homo sapiens 137-145 16939878-2 2006 In the present work, we investigated the effects of 15-deoxy-12,14-prostaglandin J2 (15 PGJ2), an endogenous ligand of PPARgamma, on the IFNgamma-induced expression of MHC class II on RPE cells. 9-deoxy-delta-9-prostaglandin D2 88-92 interferon gamma Homo sapiens 137-145 16939878-4 2006 We demonstrated that 15 PGJ2 inhibited the IFNgamma-mediated induction of MHC class II on RPE cells without affecting the level of MHC class I and CD54 expression. 9-deoxy-delta-9-prostaglandin D2 24-28 interferon gamma Homo sapiens 43-51 16790487-9 2006 Further computational and biochemical analyses show that cyfluthrin and chlorpyrifos upregulate certain targets of the interferon-gamma and insulin-signaling pathways and that they increase the protein levels of activated extracellular signal-regulated kinase 1/2, a key component of insulin signaling; interleukin 6, a key inflammatory mediator; and glial fibrillary acidic protein, a marker of inflammatory astrocyte activation. cyfluthrin 57-67 interferon gamma Homo sapiens 119-135 16687394-11 2006 By gel-shift analysis, the corresponding oligonucleotide probe bound endogenous FKHRL1 in an LPS/IFN-gamma- and PI3K-sensitive fashion. Oligonucleotides 41-56 interferon gamma Homo sapiens 97-106 17058837-4 2006 After YZG treatment, the level of IFN-gamma increased and IL-10 level decreased (P < 0.01). yzg 6-9 interferon gamma Homo sapiens 34-43 16730772-5 2006 Analysis of cellular immune responses revealed slower response rates in virus-specific IFN-gamma production to SIV Gag in the Depo-treated macaques. Glycosaminoglycans 115-118 interferon gamma Homo sapiens 87-96 16829497-11 2006 The main difference was the absence of IFNgamma and TNFalpha in TMJ CPA patients and a stronger TGFbeta and IL-1alpha expression. cpa 68-71 interferon gamma Homo sapiens 39-47 16478776-0 2006 Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1alpha/IFN-gamma, an effect partially mediated by nitric oxide. Nitric Oxide 121-133 interferon gamma Homo sapiens 78-87 16478776-6 2006 When thyrotropin (TSH)-incubated normal and GD thyrocytes were treated with IL-1alpha/IFN-gamma, TPO and ThOXs protein and mRNA expression dropped, a decrease partially prevented by L-NAME, suggesting that NO acts as a mediator of Th1 effects. NG-Nitroarginine Methyl Ester 182-188 interferon gamma Homo sapiens 86-95 16624619-7 2006 Importantly, expression of IFN-gamma by PMA/Ionomycin-activated CD56(bright) NK cells and CD3+/CD56+ cells was significantly higher in ESN when compared with controls. Ionomycin 44-53 interferon gamma Homo sapiens 27-36 16797503-5 2006 Treatment of PAEC with antisense oligomers targeting ERalpha mRNA attenuated the ability of 17betaE to inhibit the IFN-gamma-induced CD40 and CD40L protein expression. paec 13-17 interferon gamma Homo sapiens 115-124 16885379-4 2006 CADO strongly inhibited cytotoxic activity of LAK cells and attenuated the production of IFN-gamma, granulocyte macrophage colony-stimulating factor, tumor necrosis factor alpha, and macrophage inflammatory protein-1alpha by LAK cells stimulated by cross-linking of the Ly49D receptor. 2-Chloroadenosine 0-4 interferon gamma Homo sapiens 89-98 16950634-10 2006 In conclusion, our results suggest that functional genetic variants in the IL-4 promoter could influence the risk of developing CL while the polymorphism in the first intron of the IFN-gamma gene might influence the progression of disease towards CCL. Cefaclor 247-250 interferon gamma Homo sapiens 181-190 18079991-12 2006 However, interferon-gamma, and to a lesser extent, interferon-alpha, have profound effects on the catabolism of tryptophan, effectively reducing its concentration in plasma, and may thus limit brain 5-HT synthesis.Administration of endotoxin (LPS) elicits responses similar to those of IL-1. Tryptophan 112-122 interferon gamma Homo sapiens 9-25 16872374-7 2006 When evaluating data according to the amount of viable BB-12 recovered from faeces, the interferon-gamma production in blood cells was significantly reduced. bb-12 55-60 interferon gamma Homo sapiens 88-104 16872382-5 2006 In addition, all-trans-retinoic acid-treated dendritic cells could drive T cells towards T-helper cell type 2 responses with decreased secretion of interleukin-12, interferon-gamma, and increased production of interleukin-10 and interleukin-4. Tretinoin 13-36 interferon gamma Homo sapiens 164-180 16737784-10 2006 Butyrate treatment of T-bet expressing cells potentiates the expression of endogenous IFNgamma but weakly represses expression of the T-site reporter gene. Butyrates 0-8 interferon gamma Homo sapiens 86-94 16875492-8 2006 We show that the PI(3)K inhibitor, LY294002, partially inhibits the apoptotic response of the hepatocyte to IFNgamma. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 35-43 interferon gamma Homo sapiens 108-116 16820786-0 2006 Interferon-gamma enhances superoxide production in human mesangial cells via the JAK-STAT pathway. Superoxides 26-36 interferon gamma Homo sapiens 0-16 16893395-4 2006 We have profiled functional cytokine gene polymorphisms for interleukin (IL)-10, IL-15, transforming growth factors (TGF)-beta1, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma in patients with CCPA (n = 24) who were compared with other forms of aspergillosis (mostly ABPA) (n = 15) and with ethnically matched controls (n = 65-330). 2-chloro-N(6)cyclopentyladenosine 208-212 interferon gamma Homo sapiens 168-190 16820786-4 2006 Significant increases in O(2)(-) production with IFN-gamma were completely abolished by the flavin-containing enzyme inhibitor, diphenyleneiodonium (10 micromol/l), and the Janus-activated kinase (JAK)2 inhibitor, AG490 (100 micromol/l). Superoxides 25-30 interferon gamma Homo sapiens 49-58 16820786-4 2006 Significant increases in O(2)(-) production with IFN-gamma were completely abolished by the flavin-containing enzyme inhibitor, diphenyleneiodonium (10 micromol/l), and the Janus-activated kinase (JAK)2 inhibitor, AG490 (100 micromol/l). 4,6-dinitro-o-cresol 92-98 interferon gamma Homo sapiens 49-58 16820786-4 2006 Significant increases in O(2)(-) production with IFN-gamma were completely abolished by the flavin-containing enzyme inhibitor, diphenyleneiodonium (10 micromol/l), and the Janus-activated kinase (JAK)2 inhibitor, AG490 (100 micromol/l). diphenyleneiodonium 128-147 interferon gamma Homo sapiens 49-58 16820786-4 2006 Significant increases in O(2)(-) production with IFN-gamma were completely abolished by the flavin-containing enzyme inhibitor, diphenyleneiodonium (10 micromol/l), and the Janus-activated kinase (JAK)2 inhibitor, AG490 (100 micromol/l). alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 214-219 interferon gamma Homo sapiens 49-58 16820786-8 2006 These data suggest that IFN-gamma stimulates O(2)(-) production in HMCs via the JAK-STAT pathway and NAD(P)H oxidase. Superoxides 45-49 interferon gamma Homo sapiens 24-33 16474838-0 2006 The mutation in the ATP-binding region of JAK1, identified in human uterine leiomyosarcomas, results in defective interferon-gamma inducibility of TAP1 and LMP2. Adenosine Triphosphate 20-23 interferon gamma Homo sapiens 114-130 16769766-7 2006 Effects on endothelial CAM of other proinflammatory cytokines, such as interleukin-1beta and interferon-gamma, were also inhibited significantly by tripterine. celastrol 148-158 interferon gamma Homo sapiens 93-109 16769768-8 2006 In addition, 40 ng/ml halofuginone inhibited secretion of TNF-alpha, IFN-gamma, interleukin (IL)-4, IL-13, and TGF-beta (P < 0.005). halofuginone 22-34 interferon gamma Homo sapiens 69-78 16849454-5 2006 We further show that the proline-rich intracellular domain of FasL is sufficient to costimulate by enhancing the phosphorylation of Akt, ERK1/2, JNK, and FasL itself, by activating the transcription factors NFAT and AP-1, and by enhancing IFN-gamma production. Proline 25-32 interferon gamma Homo sapiens 239-248 16809572-7 2006 Proinflammatory cytokines (interleukin-1beta and interferon-gamma) upregulate Fn14 expression in hASMCs. hasmcs 97-103 interferon gamma Homo sapiens 49-65 16923369-10 2006 The early apoptosis rates of the adriamycin /etoposide + IFNgamma+TRAIL groups [(17.9 +/- 3.6)%, (14.8 +/- 3.3)%] were higher than that of the IFNgamma+TRAIL group [(3.9 +/- 1.2)% ](F=26.233, P < 0.01). Doxorubicin 33-43 interferon gamma Homo sapiens 143-151 16923369-10 2006 The early apoptosis rates of the adriamycin /etoposide + IFNgamma+TRAIL groups [(17.9 +/- 3.6)%, (14.8 +/- 3.3)%] were higher than that of the IFNgamma+TRAIL group [(3.9 +/- 1.2)% ](F=26.233, P < 0.01). Etoposide 45-54 interferon gamma Homo sapiens 143-151 16728393-6 2006 We found that partial inhibition of the MEK-ERK pathway, one of the mitogen-activated protein kinase phosphorelay modules, by U0126 partially reversed the IFNG-induced cytotoxicity in progenitors. U 0126 126-131 interferon gamma Homo sapiens 155-159 16857809-9 2006 Supernatants of in vitro CuNG-treated cultures of peripheral blood mononuclear cells from different drug-insensitive cancer patients were tested for presence of the apoptogenic cytokine IFN-gamma and its involvement in induction of apoptosis of doxorubicin-resistant CEM/ADR5000 cells. cung 25-29 interferon gamma Homo sapiens 186-195 16474838-7 2006 We now identify the G871E mutation in the ATP-binding region of Janus kinases 1, suggesting that the loss of TAP1 and LMP2 induction is a defect in the earliest steps of the IFN-gamma-signal pathway, resulting in the inability of SKN cells to upregulate the antigen-processing pathway. Adenosine Triphosphate 42-45 interferon gamma Homo sapiens 174-183 16803918-6 2006 RESULTS: In comparison with sevoflurane, propofol was associated with a lower concentration of plasma creatinine (P < 0.05) together with lower concentrations of myeloperoxidase, tumour necrosis factor-alpha, interleukin 1-ss, interferon-gamma, superoxide anion and superoxidase dismutase, malondialdehyde and inducible nitric oxide synthase (P < 0.05). Propofol 41-49 interferon gamma Homo sapiens 230-246 16818659-4 2006 The RCC tissue-derived gangliosides also suppressed IFN-gamma and, in many cases, interleukin-4 production by CD4+ T cells at concentrations (1 ng/mL-100 pg/mL) well below those that induce any detectable T-cell death (4-20 microg/mL). Gangliosides 23-35 interferon gamma Homo sapiens 52-61 16818659-8 2006 DMF10.167.4 also partially blocked the suppression of IFN-gamma production induced by RCC tissue-derived gangliosides, suggesting that GM2 plays a role in down-regulating cytokine production by CD4+ T cells. dmf10 0-5 interferon gamma Homo sapiens 54-63 16818659-8 2006 DMF10.167.4 also partially blocked the suppression of IFN-gamma production induced by RCC tissue-derived gangliosides, suggesting that GM2 plays a role in down-regulating cytokine production by CD4+ T cells. Gangliosides 105-117 interferon gamma Homo sapiens 54-63 16818659-8 2006 DMF10.167.4 also partially blocked the suppression of IFN-gamma production induced by RCC tissue-derived gangliosides, suggesting that GM2 plays a role in down-regulating cytokine production by CD4+ T cells. gm2 135-138 interferon gamma Homo sapiens 54-63 17051976-9 2006 IFN-gamma production is inhibited by IL-4, IL-10, TGFbeta, glucocorticoids, cyclosporin A and FK506. Cyclosporine 76-89 interferon gamma Homo sapiens 0-9 16842138-3 2006 Neopterin formation by human monocyte-derived macrophages and dendritic cells is induced by the pro-inflammatory cytokine interferon-gamma, which is released by activated T-lymphocytes. Neopterin 0-9 interferon gamma Homo sapiens 122-138 16842138-5 2006 Interferon-gamma also stimulates the enzyme indoleamine-2,3-dioxygenase, which degrades tryptophan to kynurenine. Tryptophan 88-98 interferon gamma Homo sapiens 0-16 16842138-5 2006 Interferon-gamma also stimulates the enzyme indoleamine-2,3-dioxygenase, which degrades tryptophan to kynurenine. Kynurenine 102-112 interferon gamma Homo sapiens 0-16 16842138-9 2006 In concert with other pro-inflammatory cytokines, interferon-gamma is the most important trigger for the formation and release of reactive oxygen species (ROS). Reactive Oxygen Species 130-153 interferon gamma Homo sapiens 50-66 16842138-9 2006 In concert with other pro-inflammatory cytokines, interferon-gamma is the most important trigger for the formation and release of reactive oxygen species (ROS). Reactive Oxygen Species 155-158 interferon gamma Homo sapiens 50-66 16931033-1 2006 Interferon (IFN)-gamma-induced expression of indoleamine 2,3-dioxygenase (IDO), an enzyme that inhibits some pathogens by limiting tryptophan availability, is transcriptionally enhanced by tumor necrosis factor (TNF)-alpha. Tryptophan 131-141 interferon gamma Homo sapiens 0-22 17051976-9 2006 IFN-gamma production is inhibited by IL-4, IL-10, TGFbeta, glucocorticoids, cyclosporin A and FK506. Tacrolimus 94-99 interferon gamma Homo sapiens 0-9 16724074-10 2006 This is the first report to describe a potential molecular mechanism responsible for selectively controlling IFN-gamma production in LPMC. lpmc 133-137 interferon gamma Homo sapiens 109-118 16827895-6 2006 PGE2 significantly and dose-dependently inhibited the proliferation and subsequent production of interleukin-4 by Cry j 1-specific TCLs and of interferon-gamma by PPD-specific TCLs upon antigen stimulation. Dinoprostone 0-4 interferon gamma Homo sapiens 143-159 16827895-9 2006 Furthermore, PGE2 and EP2 receptor agonist significantly inhibited interleukin-5 and interferon-gamma production by peripheral blood mononuclear cells in response to Cry j 1 and PPD stimulation, respectively. Dinoprostone 13-17 interferon gamma Homo sapiens 85-101 16728430-3 2006 Tracking cytokine production in PBMC initially revealed that a subset of TLR agonists including polyinosinic-polycytidylic acid (poly I:C), 3M-002, 3M-003, R-848 and single-stranded RNA trigger relatively high levels of IFN-gamma expression by NK cells. Poly I-C 96-127 interferon gamma Homo sapiens 220-229 16641133-3 2006 Here, we show that calcineurin antagonists such as cyclosporin A (CsA) or tacrolimus can markedly enhance the production of interferon-gamma (IFN-gamma) by human T cells. Cyclosporine 51-64 interferon gamma Homo sapiens 124-140 16641133-3 2006 Here, we show that calcineurin antagonists such as cyclosporin A (CsA) or tacrolimus can markedly enhance the production of interferon-gamma (IFN-gamma) by human T cells. Cyclosporine 51-64 interferon gamma Homo sapiens 142-151 16641133-3 2006 Here, we show that calcineurin antagonists such as cyclosporin A (CsA) or tacrolimus can markedly enhance the production of interferon-gamma (IFN-gamma) by human T cells. Cyclosporine 66-69 interferon gamma Homo sapiens 124-140 16641133-3 2006 Here, we show that calcineurin antagonists such as cyclosporin A (CsA) or tacrolimus can markedly enhance the production of interferon-gamma (IFN-gamma) by human T cells. Cyclosporine 66-69 interferon gamma Homo sapiens 142-151 16641133-3 2006 Here, we show that calcineurin antagonists such as cyclosporin A (CsA) or tacrolimus can markedly enhance the production of interferon-gamma (IFN-gamma) by human T cells. Tacrolimus 74-84 interferon gamma Homo sapiens 124-140 16641133-3 2006 Here, we show that calcineurin antagonists such as cyclosporin A (CsA) or tacrolimus can markedly enhance the production of interferon-gamma (IFN-gamma) by human T cells. Tacrolimus 74-84 interferon gamma Homo sapiens 142-151 16641133-5 2006 IL-27, which could mimic the effect of IL-12, was however less potent in inducing IFN-gamma production in the presence of CsA and TCR stimulation. Cyclosporine 122-125 interferon gamma Homo sapiens 82-91 16641133-7 2006 CsA-dependent IFN-gamma production is observable in therapeutic concentrations. Cyclosporine 0-3 interferon gamma Homo sapiens 14-23 16843839-3 2006 Uptake of TcSnC is altered by gram-negative infection, possibly due to the endotoxin component lipopolysaccharide (LPS) or to cytokines released during infection (e.g., TNF-alpha and IFN-gamma). tcsnc 10-15 interferon gamma Homo sapiens 183-192 16670125-6 2006 We report that dexamethasone decreases IL-12-induced STAT4 phosphorylation and IFN-gamma production and enhances IFN-beta-induced STAT4 activation and IL-10 production. Dexamethasone 15-28 interferon gamma Homo sapiens 79-88 16490253-7 2006 Trp induced HLA-G cell surface expression when present during maturation with IFN-gamma+LPS, but not with TNF-alpha. Tryptophan 0-3 interferon gamma Homo sapiens 78-87 16490253-8 2006 Kynurenine increased HLA-G expression in both TNF-alpha and IFN-gamma+LPS matured DC, and 3-hydroxyanthranilic acid had a very weak effect on HLA-G cell surface expression when present during maturation. Kynurenine 0-10 interferon gamma Homo sapiens 60-69 16490253-10 2006 Maturation with IFN-gamma+LPS in presence of kynurenine also increased HLA-G5 secretion. Kynurenine 45-55 interferon gamma Homo sapiens 16-25 16490253-13 2006 In IFN-gamma+LPS-matured DC this decreased capacity was obtained with kynurenine and 3-hydroxyanthranilic acid. Kynurenine 70-80 interferon gamma Homo sapiens 3-12 16490253-13 2006 In IFN-gamma+LPS-matured DC this decreased capacity was obtained with kynurenine and 3-hydroxyanthranilic acid. 3-Hydroxyanthranilic Acid 85-110 interferon gamma Homo sapiens 3-12 16616982-7 2006 The higher level of mRNA expressions of IFNgamma and 5-HTT diminished after fluoxetine treatment. Fluoxetine 76-86 interferon gamma Homo sapiens 40-54 16757158-7 2006 Mizolastine significantly reduced serum LTB4 and IFN-gamma levels as well as skin lesion LTB4, LTC4, LTE4 concentrations. mizolastine 0-11 interferon gamma Homo sapiens 49-58 16292516-0 2006 All-trans-retinoic acid suppresses interferon-gamma and tumor necrosis factor-alpha; a possible therapeutic agent for rheumatoid arthritis. Tretinoin 0-23 interferon gamma Homo sapiens 35-83 16292516-7 2006 In contrast, ATRA suppressed the production of IFN-gamma and TNF-alpha significantly. Tretinoin 13-17 interferon gamma Homo sapiens 47-56 16292516-9 2006 CONCLUSIONS: ATRA was demonstrated to affect the cytokine production of IFN-gamma and TNF-alpha. Tretinoin 13-17 interferon gamma Homo sapiens 72-81 16644068-6 2006 In our patient, both polymyositis and steroid therapy were predisposing factors of cutaneous leishmaniasis onset; prednisone therapy has been postulated to be associated with immune dysfunction leading to: reduced blood T cells" levels (CD4 et CD8) as well as decreased cytokine synthesis (e.g. interferon gamma). Prednisone 114-124 interferon gamma Homo sapiens 295-311 16838656-5 2006 Small-scale controlled clinical study in 1999, IFN-gamma has improved the respiratory functions of IPF, which was resistant to steroid therapy. Steroids 127-134 interferon gamma Homo sapiens 47-56 16882589-4 2006 Intracellular expression of both IFN-gamma and IL-4 after culture with MTX was significantly lower than those after culture without MTX in patients with RA. Methotrexate 71-74 interferon gamma Homo sapiens 33-42 16882589-4 2006 Intracellular expression of both IFN-gamma and IL-4 after culture with MTX was significantly lower than those after culture without MTX in patients with RA. Methotrexate 132-135 interferon gamma Homo sapiens 33-42 16882589-5 2006 Although no significant difference was observed in SLAM expression on freshly isolated CD4+ T-cells between patients with RA and the controls, MTX significantly decreased SLAM expression on both activated IFN-gamma+ and IL-4+CD4+ T-cells in patients with RA. Methotrexate 143-146 interferon gamma Homo sapiens 205-214 16882589-6 2006 CONCLUSION: In vitro modulation of the cytokine network by MTX, IFN-gamma, and IL-4 is one of the major targets for MTX, and production of IFN-gamma and IL-4 by PBMCs may be suppressed by SLAM on activated CD4+ T-cell in patients with RA. Methotrexate 116-119 interferon gamma Homo sapiens 64-73 16867276-6 2006 The activation of IP-10 and the deacetylation of histone H4 at the ISRE site induced by IFN-gamma were inhibited or blocked by histone deacetylase (HDAC) inhibitor trichostatin A (TSA). trichostatin A 164-178 interferon gamma Homo sapiens 88-97 16867276-6 2006 The activation of IP-10 and the deacetylation of histone H4 at the ISRE site induced by IFN-gamma were inhibited or blocked by histone deacetylase (HDAC) inhibitor trichostatin A (TSA). trichostatin A 180-183 interferon gamma Homo sapiens 88-97 16704888-8 2006 Further, the adjuvant effects of poly (I:C) were dependent on the endogenous levels of type I IFNs, TNF-alpha, IFN-gamma, IL-12, and IL-15. Poly I-C 33-43 interferon gamma Homo sapiens 111-120 16721359-7 2006 With respect to ACN/neo, the ACN/IFN-gamma xenografts showed more terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling-positive human and murine endothelial cells, suggesting that inhibition of angiogenesis by IFN-gamma was dependent on the induction of apoptosis, likely mediated by nitric oxide. neo 20-23 interferon gamma Homo sapiens 33-42 16721359-7 2006 With respect to ACN/neo, the ACN/IFN-gamma xenografts showed more terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling-positive human and murine endothelial cells, suggesting that inhibition of angiogenesis by IFN-gamma was dependent on the induction of apoptosis, likely mediated by nitric oxide. deoxyuridine triphosphate 113-117 interferon gamma Homo sapiens 33-42 16721359-7 2006 With respect to ACN/neo, the ACN/IFN-gamma xenografts showed more terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling-positive human and murine endothelial cells, suggesting that inhibition of angiogenesis by IFN-gamma was dependent on the induction of apoptosis, likely mediated by nitric oxide. Nitric Oxide 302-314 interferon gamma Homo sapiens 33-42 16723718-7 2006 IFN-gamma increased Fas-induced apoptosis in vitro by 46 +/- 8% (mean +/- SEM, P = 0.04), an event that could be abrogated by inhibition of PI3K, Akt, or Jak-2. ammonium ferrous sulfate 20-23 interferon gamma Homo sapiens 0-9 16428271-6 2006 The mitogen-activated protein kinase kinase inhibitor U0126 totally reversed the inhibition observed with IFN-gamma, suggesting the involvement of the extracellular signal-regulated kinase pathway in this effect. U 0126 54-59 interferon gamma Homo sapiens 106-115 16723718-8 2006 IFN-gamma also increased Fas-induced apoptosis in vivo 7.5- to 15-fold (P < 0.05) in human arteries transplanted into immunodeficient mice, accompanied by increased Fas and phospho-Ser727-Stat1. ammonium ferrous sulfate 25-28 interferon gamma Homo sapiens 0-9 16723718-8 2006 IFN-gamma also increased Fas-induced apoptosis in vivo 7.5- to 15-fold (P < 0.05) in human arteries transplanted into immunodeficient mice, accompanied by increased Fas and phospho-Ser727-Stat1. ammonium ferrous sulfate 168-171 interferon gamma Homo sapiens 0-9 16723718-9 2006 We conclude that IFN-gamma primes VSMCs to Fas-induced apoptosis, in part by relocation of Fas to the cell surface, a process that involves PI3K, Akt, and Jak-2/Stat1. vsmcs 34-39 interferon gamma Homo sapiens 17-26 16723718-9 2006 We conclude that IFN-gamma primes VSMCs to Fas-induced apoptosis, in part by relocation of Fas to the cell surface, a process that involves PI3K, Akt, and Jak-2/Stat1. ammonium ferrous sulfate 43-46 interferon gamma Homo sapiens 17-26 16723718-9 2006 We conclude that IFN-gamma primes VSMCs to Fas-induced apoptosis, in part by relocation of Fas to the cell surface, a process that involves PI3K, Akt, and Jak-2/Stat1. ammonium ferrous sulfate 91-94 interferon gamma Homo sapiens 17-26 16154133-5 2006 Using primary T cells as well as differentiated T(H)1 and T(H)2 cells, the immunomodulatory effect of atorvastatin on cells secreting IFN-gamma (T(H)1 response) and IL-4 (T(H)2 response) was investigated. Atorvastatin 102-114 interferon gamma Homo sapiens 134-143 16855144-6 2006 Testosterone, in contrast, inhibited (IL-2, IL-4, IL-10) or tended to inhibit stimulated secretion of these cytokines (TNF, IFNgamma). Testosterone 0-12 interferon gamma Homo sapiens 124-132 16709188-4 2006 IFNgamma, the sole type II IFN, is structurally unrelated, binds to a different receptor and, as a dimer, strongly interacts with HS (heparan sulphate). Heparitin Sulfate 130-132 interferon gamma Homo sapiens 0-8 16709188-4 2006 IFNgamma, the sole type II IFN, is structurally unrelated, binds to a different receptor and, as a dimer, strongly interacts with HS (heparan sulphate). Heparitin Sulfate 134-150 interferon gamma Homo sapiens 0-8 16709188-6 2006 IFNgamma binding to HS controls the blood clearance, the subsequent tissue targeting and the local accumulation of the cytokine. Heparitin Sulfate 20-22 interferon gamma Homo sapiens 0-8 16709188-8 2006 The binding site encompasses an N-acetylated glucosamine-rich domain separating two highly sulphated sequences that each binds to one IFNgamma monomer. Nitrogen 32-33 interferon gamma Homo sapiens 134-142 16709188-8 2006 The binding site encompasses an N-acetylated glucosamine-rich domain separating two highly sulphated sequences that each binds to one IFNgamma monomer. Glucosamine 45-56 interferon gamma Homo sapiens 134-142 16712960-4 2006 In vitro, LLDT-8 inhibited primary T cells proliferation, division, IL-2 and IFN-gamma production stimulated with anti-CD3/28. 5alpha-Hydroxytriptolide 10-16 interferon gamma Homo sapiens 77-86 16734607-8 2006 Furthermore, vitamin A supplementation was significantly associated with an increased ratio of mitogen-induced proinflammatory cytokine (IFN-gamma) to anti-inflammatory cytokine (IL-10) during pregnancy and in the postpartum period. Vitamin A 13-22 interferon gamma Homo sapiens 137-146 16728283-5 2006 Cultivation in the presence of SAHA broadly inhibited lipopolysaccharide (LPS) and alloantigen-induced cytokine/chemokine production in vitro and led also to a significant decrease in interferon-gamma and tumor necrosis factor-alpha levels in vivo following induction of GVHD. Vorinostat 31-35 interferon gamma Homo sapiens 184-232 16644475-2 2006 We show here that a commonly used generic antidepressant bupropion, in wide use worldwide to treat depression in humans for a decade now, profoundly lowers levels of TNF, interferon-gamma, and interleukin-1 beta in vivo, in a mouse lipopolysaccharide (LPS) induced inflammation model. Bupropion 57-66 interferon gamma Homo sapiens 171-187 16764700-5 2006 Pentoxyfilline resulted in decreased expression of mRNA of liver IL-1beta, TNF-alpha and IFN-gamma: 144.2 versus 83.5 molecules of IL-1beta (P < 0.05), TNF-alpha 194.3 versus 17.6 molecules (P = 0.03) and IFN-gamma 26.1 versus 0.5 molecules (P = 0.04). Pentoxifylline 0-14 interferon gamma Homo sapiens 89-98 16764700-5 2006 Pentoxyfilline resulted in decreased expression of mRNA of liver IL-1beta, TNF-alpha and IFN-gamma: 144.2 versus 83.5 molecules of IL-1beta (P < 0.05), TNF-alpha 194.3 versus 17.6 molecules (P = 0.03) and IFN-gamma 26.1 versus 0.5 molecules (P = 0.04). Pentoxifylline 0-14 interferon gamma Homo sapiens 208-217 16764700-6 2006 Following PTX, PBMC exhibited a decrease in IFN-gamma mRNA 12.2 versus 1.5 molecules (P = 0.028) and CXCL8 4.2 versus 2.5 molecules (P = 0.027). Pentoxifylline 10-13 interferon gamma Homo sapiens 44-53 16836847-15 2006 bDNA could stimulate secretion of IFN-gamma by CBMC and inhibit secretion of IL-4. cbmc 47-51 interferon gamma Homo sapiens 34-43 16722616-3 2006 We investigated IFN-gamma responses to specific TB antigens among Indian health care workers (HCWs) before, and after LTBI preventive therapy. Terbium 48-50 interferon gamma Homo sapiens 16-25 16914093-0 2006 Arsenic enhances the apoptosis induced by interferon gamma: key role of IRF-1. Arsenic 0-7 interferon gamma Homo sapiens 42-58 16682645-6 2006 The Th2-biased transcription factor profile induced by simvastatin-treated DCs also was accompanied by increased Th2 (IL-4, IL-5, and IL-13) and decreased Th1 (IFN-gamma) cytokine secretion from the T cells. Simvastatin 55-66 interferon gamma Homo sapiens 160-169 16914097-7 2006 Our in vitro results indicate a correlation between nitrite and IFN-gamma production in PBMC culture supernatants. Nitrites 52-59 interferon gamma Homo sapiens 64-73 16914093-2 2006 IFNgamma treatment of cells leads to tyrosine phosphorylation of STAT1 followed by dimerization that accumulates in the nucleus. Tyrosine 37-45 interferon gamma Homo sapiens 0-8 16914093-5 2006 Here, we show that in the human fibrosarcoma cell line 2fTGH, As2O3 prolongs IFNgamma-induced STAT1 phosphorylation resulting in persistent binding of STAT1 to GAS motif leading to an increase in IRF-1 expression which correlated with both higher anti-proliferative effect and increased apoptosis. Arsenic Trioxide 62-67 interferon gamma Homo sapiens 77-85 16631732-8 2006 Naive T cells co-cultured with allogeneic T-cadinol-primed dendritic cells or calamenene-primed dendritic cells at 1:5 dendritic cells/T cell ratio turned into typical Th1 cells which produced large quantities of interferon-gamma (IFN-gamma) and released small amounts of IL-4 depending on IL-12 secretion. calamenene 78-88 interferon gamma Homo sapiens 213-229 16197973-11 2006 In CTL assay, the production of IFN-gamma and 51Cr release on SUL-1-treated DC were more augmented than of immature DC or LPS-treated DC. sul-1 62-67 interferon gamma Homo sapiens 32-41 16581161-9 2006 Poly-L-arginine was required for the aimed-for Th1/Tc1-type immunity (IFN-gamma secreting T cells). polyarginine 0-15 interferon gamma Homo sapiens 51-79 16631732-8 2006 Naive T cells co-cultured with allogeneic T-cadinol-primed dendritic cells or calamenene-primed dendritic cells at 1:5 dendritic cells/T cell ratio turned into typical Th1 cells which produced large quantities of interferon-gamma (IFN-gamma) and released small amounts of IL-4 depending on IL-12 secretion. calamenene 78-88 interferon gamma Homo sapiens 231-240 16133109-10 2006 However, tumor-derived prostanoid blockade recovered the IFN-gamma levels secreted by lymphocytes stimulated with SF-treated DC, whereas prostanoid/IL-6 or prostanoid/IL-10 blockade decreased IL-10 production only by SCC-DC-stimulated lymphocytes. Prostaglandins 23-33 interferon gamma Homo sapiens 57-66 16603595-5 2006 Interferon-gamma and tumor necrosis factor-alpha, but not direct rhinovirus infection, decreased pH, an effect partly associated with decreased ammonium concentrations. Ammonium Compounds 144-152 interferon gamma Homo sapiens 0-48 16507564-3 2006 We designed this trial to investigate the modification of the vascular endothelial growth factor (VEGF) and interferon-gamma (IFN-gamma) in advanced colorectal cancer patients during treatment with a weekly combination of cetuximab plus irinotecan. Irinotecan 237-247 interferon gamma Homo sapiens 108-124 16507564-3 2006 We designed this trial to investigate the modification of the vascular endothelial growth factor (VEGF) and interferon-gamma (IFN-gamma) in advanced colorectal cancer patients during treatment with a weekly combination of cetuximab plus irinotecan. Irinotecan 237-247 interferon gamma Homo sapiens 126-135 16282346-9 2006 The addition of bortezomib decreased not only the proliferation and viability of activated T lymphocytes but also the levels of IFNgamma and IL-2, which were significantly decreased among activated T cells cultured with bortezomib at doses ranging from 10 to 100 nM. Bortezomib 16-26 interferon gamma Homo sapiens 128-136 16282346-9 2006 The addition of bortezomib decreased not only the proliferation and viability of activated T lymphocytes but also the levels of IFNgamma and IL-2, which were significantly decreased among activated T cells cultured with bortezomib at doses ranging from 10 to 100 nM. Bortezomib 220-230 interferon gamma Homo sapiens 128-136 16261283-2 2006 The proinflammatory cytokine interferon-gamma in various cells, including monocytes, induces the enzyme indoleamine (2,3)-dioxygenase (IDO), which converts tryptophan to kynurenine. Tryptophan 156-166 interferon gamma Homo sapiens 29-45 16261283-2 2006 The proinflammatory cytokine interferon-gamma in various cells, including monocytes, induces the enzyme indoleamine (2,3)-dioxygenase (IDO), which converts tryptophan to kynurenine. Kynurenine 170-180 interferon gamma Homo sapiens 29-45 16427044-6 2006 Strikingly, IFN-gamma-induced apoptosis and growth inhibition of M12 cells were associated with persistent suppression of the constitutive tyrosine-phosphorylated STAT3 (pY-STAT3). Tyrosine 139-147 interferon gamma Homo sapiens 12-21 16427044-8 2006 Inhibition of PI-3K with low-dose LY294002, or MAPK with PD98059 also suppressed the mTOR/p70 S6k pathway, and correlated with the blockage of IFN-gamma-induced dephosphorylation of pY-STAT3. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 34-42 interferon gamma Homo sapiens 143-152 16427044-7 2006 The IFN-gamma-induced dephosphorylation of pY-STAT3, however, was inhibited when the mTOR pathway was specifically blocked by rapamycin. Sirolimus 126-135 interferon gamma Homo sapiens 4-13 16427044-8 2006 Inhibition of PI-3K with low-dose LY294002, or MAPK with PD98059 also suppressed the mTOR/p70 S6k pathway, and correlated with the blockage of IFN-gamma-induced dephosphorylation of pY-STAT3. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 57-64 interferon gamma Homo sapiens 143-152 16427044-9 2006 Simultaneously, treatment with LY294002, PD98059, or rapamycin abolished IFN-gamma-induced apoptosis in M12 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 31-39 interferon gamma Homo sapiens 73-82 16713974-2 2006 We report that IFN-gamma augments induction of TNFalpha by TLR ligands, immune complexes, and zymosan by suppressing IL-10 production and thereby interrupting Stat3-mediated feedback inhibition. Zymosan 94-101 interferon gamma Homo sapiens 15-24 16427044-9 2006 Simultaneously, treatment with LY294002, PD98059, or rapamycin abolished IFN-gamma-induced apoptosis in M12 cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 41-48 interferon gamma Homo sapiens 73-82 16427044-9 2006 Simultaneously, treatment with LY294002, PD98059, or rapamycin abolished IFN-gamma-induced apoptosis in M12 cells. Sirolimus 53-62 interferon gamma Homo sapiens 73-82 16675345-6 2006 Although the whole staphylococcal bacteria increased IFN-gamma responses, the purified TLR2 ligands lipoteichoic acid and Pam3CSK4 inhibited HDM-specific IFN-gamma synthesis. lipoteichoic acid 100-117 interferon gamma Homo sapiens 154-163 16621994-2 2006 We show in this study that both atorvastatin and simvastatin induced proinflammatory responses in mitogen-activated PBMCs by increasing the number of T cells secreting IFN-gamma. Atorvastatin 32-44 interferon gamma Homo sapiens 168-177 16621994-2 2006 We show in this study that both atorvastatin and simvastatin induced proinflammatory responses in mitogen-activated PBMCs by increasing the number of T cells secreting IFN-gamma. Simvastatin 49-60 interferon gamma Homo sapiens 168-177 16614431-8 2006 Vitamin A-supplemented children infected with enteropathogenic E. coli (EPEC) had reduced IL-4 and IFN-gamma levels [odds ratio (OR) = 0.3, 95% CI 0.13-0.67 and OR = 0.34, 95% CI 0.14-0.83, respectively] compared with children in the placebo group. Vitamin A 0-9 interferon gamma Homo sapiens 99-108 16678181-8 2006 Interferon-gamma, a cytokine known to be produced in malaria infection, induces increased expression, by microvascular endothelial cells, of the haem enzyme indoleamine 2,3-dioxygenase, the first enzyme in the kynurenine pathway of tryptophan metabolism. Kynurenine 210-220 interferon gamma Homo sapiens 0-16 16678181-8 2006 Interferon-gamma, a cytokine known to be produced in malaria infection, induces increased expression, by microvascular endothelial cells, of the haem enzyme indoleamine 2,3-dioxygenase, the first enzyme in the kynurenine pathway of tryptophan metabolism. Tryptophan 232-242 interferon gamma Homo sapiens 0-16 16614431-10 2006 In contrast, IL-4 levels increased (OR = 2.14, 95% CI 0.94-4.87) and IFN-gamma levels decreased (OR = 0.51, 95% CI 0.26-0.99) among vitamin A-supplemented children with diarrhea compared with children in the placebo group. Vitamin A 132-141 interferon gamma Homo sapiens 69-78 16478632-1 2006 In mammals, interferon-gamma-inducible-lysosomal thiol reductase (GILT) has been demonstrated to play a key role in the processing and presentation of MHC class II-restricted antigen (Ag) by catalyzing disulfide bond reduction, thus unfolding native protein Ag and facilitating subsequent cleavage by proteases. Disulfides 202-211 interferon gamma Homo sapiens 12-28 16618789-7 2006 Glucocorticosteroids have a role in inhibiting the IFN-gamma response, acting directly on T cells or indirectly through IL-12. glucocorticosteroids 0-20 interferon gamma Homo sapiens 51-60 16755920-8 2006 After renaturalized with glutathione buffer, the promoting effect of it on the production of IFN-y in PBMC was detected by RT-PCR. Glutathione 25-36 interferon gamma Homo sapiens 93-98 16757248-8 2006 Significant increases in the number of IFN-gamma spots preceded the onset of acute rejection events and were decreased by supplemental IV steroid administration. Steroids 138-145 interferon gamma Homo sapiens 39-48 16510232-7 2006 In the case of mAb-activation, secretion of interleukin (IL)-1 beta, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma was greatly inhibited at low Cd doses compared to production of IL-4 and IL-10. Cadmium 160-162 interferon gamma Homo sapiens 108-130 16458002-1 2006 Glycoceramides can activate NKT cells by binding with CD1d to produce IFN-gamma, IL-4, and other cytokines. glycoceramides 0-14 interferon gamma Homo sapiens 70-79 16585600-3 2006 Adherent RAW264.7 macrophages and human monocytes exhibited NAD(P)H autofluorescence oscillation periods of approximately 20 s. IFN-gamma increased the oscillatory amplitude, which was required for CpG DNA-mediated metabolic changes. nad(p)h 60-67 interferon gamma Homo sapiens 128-137 16585600-12 2006 Although CpG DNA alone had no effect, IFN-gamma plus CpG enhanced NO and reactive oxygen metabolite release compared with IFN-gamma treatment alone. Oxygen 82-88 interferon gamma Homo sapiens 38-47 16613677-10 2006 CONCLUSION: IFN-gamma can up-regulate Her-2/neu expression and increase the binding of 131I-Herceptin, hence, improve the inhibitory effect of 131I-Herceptin on proliferation of breast cancer cells. 131i-herceptin 87-101 interferon gamma Homo sapiens 12-21 16564033-6 2006 Only the specific inducible nitric oxide synthase (iNOS) inhibitor S-methylisothiourea, and hypothermia, which is known to suppress microglial iNOS expression, prevented cell death after LPS/IFN-gamma activation. S-methylisothiopseudouronium 67-86 interferon gamma Homo sapiens 191-200 16380218-6 2006 Stat-1 specific inhibitor, fludarabine (50 muM) abolished IFN-gamma stimulated OIP-1 gene promoter activity. fludarabine 27-38 interferon gamma Homo sapiens 58-67 16613677-10 2006 CONCLUSION: IFN-gamma can up-regulate Her-2/neu expression and increase the binding of 131I-Herceptin, hence, improve the inhibitory effect of 131I-Herceptin on proliferation of breast cancer cells. 131i-herceptin 143-157 interferon gamma Homo sapiens 12-21 16630152-10 2006 RESULTS: Fluvastatin inhibited the proliferation of PBMCs and decreased the production of IL-5, IFN-gamma, CCL17, and CXCL10 after allergen-specific and non-allergen-specific stimulation; all these effects, except for decreased CXCL10 production, were partially reversed by mevalonic acid. Fluvastatin 9-20 interferon gamma Homo sapiens 96-105 16410460-6 2006 In contrast, rosiglitazone significantly reduced CD4-lymphocyte content as well as macrophage HLA-DR expression in the shoulder region, reflecting less inflammatory activation of these cells by lymphocyte interferon-gamma. Rosiglitazone 13-26 interferon gamma Homo sapiens 205-221 16458073-2 2006 Ciprofloxacin (CIP), which is useful for the clinical treatment of infections due to its antibacterial properties after transplantation, was shown to suppress the IFN-gamma and IL-12 production, the lymphocyte proliferation and the ICAM-1, B7.1, B7.2 and CD40 expression on monocytes during MLR in the presence of IL-18. Ciprofloxacin 0-13 interferon gamma Homo sapiens 163-172 16671908-0 2006 Inhibitory effects of Triptolide on interferon-gamma-induced human leucocyte antigen-DR, intercellular adhesion molecule-1, CD40 expression on retro-ocular fibroblasts derived from patients with Graves" ophthalmopathy. triptolide 22-32 interferon gamma Homo sapiens 36-52 16671908-13 2006 When the concentration ranged from 0.1 microg/L to 10 microg/L, Triptolide inhibited IFN-gamma-induced RFs activation in a dose-dependent manner. triptolide 64-74 interferon gamma Homo sapiens 85-94 16671908-14 2006 It was also found that Triptolide had the same inhibiting effects on IFN-gamma-induced RFs and skin fibroblasts from patients with normal individual conditions. triptolide 23-33 interferon gamma Homo sapiens 69-78 16671908-15 2006 CONCLUSIONS: Triptolide could inhibit IFN-gamma-induced activation of RFs derived from patients with Graves" ophthalmopathy. triptolide 13-23 interferon gamma Homo sapiens 38-47 16413536-1 2006 The Death Associated Protein 3 (DAP3), a GTP-binding constituent of the small subunit of the mitochondrial ribosome, is implicated in the TNFalpha and IFNgamma apoptotic pathways of the cell and is involved in the maintenance of the mitochondrial network. Guanosine Triphosphate 41-44 interferon gamma Homo sapiens 151-159 16533725-0 2006 The effect of fludarabine on interferon-gamma production by lymphoid cells from healthy donors and patients with B-cell chronic lymphocytic leukemia. fludarabine 14-25 interferon gamma Homo sapiens 29-45 16533725-2 2006 We here show that exposure of peripheral blood lymphocytes from healthy donors and B-CLL patients to fludarabine increases in vitro production of interferon-gamma, a key cytokine in the pathogenesis of AHA. fludarabine 101-112 interferon gamma Homo sapiens 146-162 16556265-0 2006 Histamine and prostaglandin E up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-gamma-induced CXCL10 production by immature human dendritic cells. Histamine 0-9 interferon gamma Homo sapiens 122-131 16556265-0 2006 Histamine and prostaglandin E up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-gamma-induced CXCL10 production by immature human dendritic cells. Prostaglandins E 14-29 interferon gamma Homo sapiens 122-131 16556265-8 2006 In addition, histamine and PGE2 down-regulated IFN-gamma-induced CXCL10 production by monocyte-derived DC. Histamine 13-22 interferon gamma Homo sapiens 47-56 16556265-8 2006 In addition, histamine and PGE2 down-regulated IFN-gamma-induced CXCL10 production by monocyte-derived DC. Dinoprostone 27-31 interferon gamma Homo sapiens 47-56 16556265-10 2006 Finally, histamine and PGE2 also up-regulated CCL17 and CCL22 and decreased IFN-gamma-induced CXCL10 production by purified human myeloid DC. Histamine 9-18 interferon gamma Homo sapiens 76-85 16556265-10 2006 Finally, histamine and PGE2 also up-regulated CCL17 and CCL22 and decreased IFN-gamma-induced CXCL10 production by purified human myeloid DC. Dinoprostone 23-27 interferon gamma Homo sapiens 76-85 16525632-3 2006 In KU19-20 cells, cell proliferation and survivin expression were significantly induced by IGF-1, whereas they were inhibited by a novel NF-kappaB inhibitor dehydroxymethyl-epoxyquinomicin (DHMEQ) and IFN-gamma. dehydroxymethylepoxyquinomicin 190-195 interferon gamma Homo sapiens 201-210 16831298-4 2006 Accordingly, Vgamma9Vdelta2 T lymphocytes cultured with aminobisphosphonates and IL-2 showed a major content of IFN-gamma and acquired the ability to kill tumor target cells. aminobisphosphonates 56-76 interferon gamma Homo sapiens 112-121 16630954-0 2006 Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gamma. Fatty Acids 27-38 interferon gamma Homo sapiens 81-90 16630954-8 2006 If neonates had either EPA or AA levels in the highest quartile, their Der f 1 IFN-gamma levels were 90% lower (P = .0001) than those with both EPA and AA levels in the lowest 3 quartiles. Eicosapentaenoic Acid 23-26 interferon gamma Homo sapiens 79-88 16595469-13 2006 In addition to its effects on interleukin-6 signaling, titanium also profoundly inhibited the interferon-gamma-induced activation of STAT1 and the expression of interferon-gamma-inducible genes, whereas polymethylmethacrylate had no effect on interferon-gamma signaling. Titanium 55-63 interferon gamma Homo sapiens 94-110 16595469-13 2006 In addition to its effects on interleukin-6 signaling, titanium also profoundly inhibited the interferon-gamma-induced activation of STAT1 and the expression of interferon-gamma-inducible genes, whereas polymethylmethacrylate had no effect on interferon-gamma signaling. Titanium 55-63 interferon gamma Homo sapiens 161-177 16595469-13 2006 In addition to its effects on interleukin-6 signaling, titanium also profoundly inhibited the interferon-gamma-induced activation of STAT1 and the expression of interferon-gamma-inducible genes, whereas polymethylmethacrylate had no effect on interferon-gamma signaling. Titanium 55-63 interferon gamma Homo sapiens 161-177 16595469-14 2006 CONCLUSIONS: Titanium inhibits both interferon-gamma and interleukin-6 signaling in human osteoclast precursor cells, whereas polymethylmethacrylate bone cement inhibits only the latter. Titanium 13-21 interferon gamma Homo sapiens 36-52 16595469-16 2006 In contrast, titanium inhibition of interferon-gamma signaling is not dependent on mitogen-activated protein kinase activation and is accompanied by only modest induction of the interferon-gamma inhibitor SOCS1. Titanium 13-21 interferon gamma Homo sapiens 36-52 16595469-16 2006 In contrast, titanium inhibition of interferon-gamma signaling is not dependent on mitogen-activated protein kinase activation and is accompanied by only modest induction of the interferon-gamma inhibitor SOCS1. Titanium 13-21 interferon gamma Homo sapiens 178-194 16543949-3 2006 Addition in culture of HP-NAP, as an immune modulator, to antigen-induced T cell lines resulted in a remarkable increase in the number of IFN-gamma-producing T cells and decrease of IL-4-secreting cells, thus shifting the cytokine profile of antigen-activated human T cells from Th2 to a Th1 cytotoxic phenotype. hp-nap 23-29 interferon gamma Homo sapiens 138-147 16552706-2 2006 Using beryllium-specific CD4+ T cell lines derived from the bronchoalveolar lavage (BAL) fluid of CBD patients, we show that purified CD4+ T cells produced significant amounts of IFN-gamma and TNF-alpha upon exposure to beryllium in the absence of antigen-presenting cells (APC). Beryllium 6-15 interferon gamma Homo sapiens 179-188 16552706-2 2006 Using beryllium-specific CD4+ T cell lines derived from the bronchoalveolar lavage (BAL) fluid of CBD patients, we show that purified CD4+ T cells produced significant amounts of IFN-gamma and TNF-alpha upon exposure to beryllium in the absence of antigen-presenting cells (APC). Beryllium 220-229 interferon gamma Homo sapiens 179-188 16581346-3 2006 As disruption of mitochondrial transmembrane potential (DeltaPsim), Leu-Glu-His-Asp ase (IETD ase) activity, and the appearance of hypodiploid DNA + cells were markedly suppressed in IFN-gamma-treated FLS in response to TRAIL, IFN-gamma-induced suppression was supposed to achieve at upstream of caspase-8. Leucine 68-71 interferon gamma Homo sapiens 183-192 16581346-3 2006 As disruption of mitochondrial transmembrane potential (DeltaPsim), Leu-Glu-His-Asp ase (IETD ase) activity, and the appearance of hypodiploid DNA + cells were markedly suppressed in IFN-gamma-treated FLS in response to TRAIL, IFN-gamma-induced suppression was supposed to achieve at upstream of caspase-8. Glutamic Acid 72-75 interferon gamma Homo sapiens 183-192 16581346-3 2006 As disruption of mitochondrial transmembrane potential (DeltaPsim), Leu-Glu-His-Asp ase (IETD ase) activity, and the appearance of hypodiploid DNA + cells were markedly suppressed in IFN-gamma-treated FLS in response to TRAIL, IFN-gamma-induced suppression was supposed to achieve at upstream of caspase-8. Histidine 76-79 interferon gamma Homo sapiens 183-192 16581346-3 2006 As disruption of mitochondrial transmembrane potential (DeltaPsim), Leu-Glu-His-Asp ase (IETD ase) activity, and the appearance of hypodiploid DNA + cells were markedly suppressed in IFN-gamma-treated FLS in response to TRAIL, IFN-gamma-induced suppression was supposed to achieve at upstream of caspase-8. Aspartic Acid 80-83 interferon gamma Homo sapiens 183-192 16581346-5 2006 Janus kinase (JAK)-induced phosphorylation of STAT1/3/6, which acts at translational regulation, seemed to be crucial because chemical inhibition of JAK as well as cycloheximide (CHX) abolished both the phosphorylation of STAT1/3/6 and the IFN-gamma-induced inhibitory effect. Cycloheximide 164-177 interferon gamma Homo sapiens 240-249 16581346-5 2006 Janus kinase (JAK)-induced phosphorylation of STAT1/3/6, which acts at translational regulation, seemed to be crucial because chemical inhibition of JAK as well as cycloheximide (CHX) abolished both the phosphorylation of STAT1/3/6 and the IFN-gamma-induced inhibitory effect. Cycloheximide 179-182 interferon gamma Homo sapiens 240-249 16704296-0 2006 Nicotinamide reduces high secretion of IFN-gamma in high-risk relatives even though it does not prevent type 1 diabetes. Niacinamide 0-12 interferon gamma Homo sapiens 39-48 16704296-9 2006 Nicotinamide caused decreased spontaneous (p = 0.05) and in vitro autoantigen-induced IFN-gamma secretion (p < 0.05) and may play a role in immune regulation, even though it has not been shown to prevent T1D. Niacinamide 0-12 interferon gamma Homo sapiens 86-95 16556679-3 2006 We now demonstrate that heparin abrogates apoptosis of primary first trimester villous trophoblast in response to treatment with the pro-inflammatory cytokines interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha. Heparin 24-31 interferon gamma Homo sapiens 160-182 16461739-5 2006 The phenotypical conversion in men older than 30 years is mirrored by an increased proliferative response of Vgamma9/Vdelta2 T cells and a reduced interferon-gamma secretion upon stimulation with isopentenyl pyrophosphate in vitro. isopentenyl pyrophosphate 196-221 interferon gamma Homo sapiens 147-163 16569229-14 2006 Pre-treatment with IFN-gamma increased the levels of cytoplasmic phospholipase A2 in SH-SY5Y cells and increased prostaglandin E2 production in response to amyloid-beta1-42. Dinoprostone 113-129 interferon gamma Homo sapiens 19-28 16569229-16 2006 IFN-gamma increased the levels of cytoplasmic phospholipase A2 in cultured neuronal cells and increased expression of cytoplasmic phospholipase A2 was associated with increased production of prostaglandin E2 in response to amyloid-beta1-42 or HuPrP82-146. Dinoprostone 191-207 interferon gamma Homo sapiens 0-9 16574426-3 2006 ATP-depletion or inhibition of N-glycosylation was found to cause IFN-gamma to accumulate into detergent-insoluble aggregates in the ER. Adenosine Triphosphate 0-3 interferon gamma Homo sapiens 66-75 16376465-8 2006 Further, the incorporation of GPI-hIL-12 onto tumor membrane vesicles induced proliferation of T cells and the release of IFN-gamma by activated T cells. gpi-hil-12 30-40 interferon gamma Homo sapiens 122-131 16574426-3 2006 ATP-depletion or inhibition of N-glycosylation was found to cause IFN-gamma to accumulate into detergent-insoluble aggregates in the ER. Nitrogen 31-32 interferon gamma Homo sapiens 66-75 16574426-5 2006 Interaction of the five first chaperones with IFN-gamma was regulated co-ordinately by ATP. Adenosine Triphosphate 87-90 interferon gamma Homo sapiens 46-55 16439692-7 2006 Moreover, simvastatin lowers the IFN-gamma-induced expression of RFX5 and MHC II in addition to repressing collagen expression. Simvastatin 10-21 interferon gamma Homo sapiens 33-42 17075286-8 2006 RESULTS: We developed a new system for measuring hIFN-gamma using Allophycocyanine (APC) fluorescent protein and compared it with the previous method using Cy5.5. allophycocyanine 66-82 interferon gamma Homo sapiens 49-59 16278302-4 2006 beta-agonist and PGE2 also inhibited phorbol myristate acetate (PMA) + calcimycin-stimulated IFN-gamma and IL-2 (but not IL-13) production, suggesting that upstream CD3-initiated signaling is not the sole locus of PKA actions. Dinoprostone 17-21 interferon gamma Homo sapiens 93-102 16272460-3 2006 Using normal and fibrotic human lung fibroblasts and the human lung fibroblast cell line, MRC-5, we examined the regulation of Fas-induced apoptosis by the proinflammatory cytokines TNF-alpha and IFN-gamma. ammonium ferrous sulfate 127-130 interferon gamma Homo sapiens 196-205 16278302-4 2006 beta-agonist and PGE2 also inhibited phorbol myristate acetate (PMA) + calcimycin-stimulated IFN-gamma and IL-2 (but not IL-13) production, suggesting that upstream CD3-initiated signaling is not the sole locus of PKA actions. Tetradecanoylphorbol Acetate 37-62 interferon gamma Homo sapiens 93-102 16278302-4 2006 beta-agonist and PGE2 also inhibited phorbol myristate acetate (PMA) + calcimycin-stimulated IFN-gamma and IL-2 (but not IL-13) production, suggesting that upstream CD3-initiated signaling is not the sole locus of PKA actions. Tetradecanoylphorbol Acetate 64-67 interferon gamma Homo sapiens 93-102 16278302-4 2006 beta-agonist and PGE2 also inhibited phorbol myristate acetate (PMA) + calcimycin-stimulated IFN-gamma and IL-2 (but not IL-13) production, suggesting that upstream CD3-initiated signaling is not the sole locus of PKA actions. Calcimycin 71-81 interferon gamma Homo sapiens 93-102 16278302-5 2006 Differential regulation of PMA-stimulated p38, p42/p44, and NF-kappaB explained the capacity of PGE2 and beta-agonist to inhibit IFN-gamma but not IL-13 production. Dinoprostone 96-100 interferon gamma Homo sapiens 129-138 16278302-6 2006 The inhibition of CD3 + CD28-stimulated IL-13 production by both beta-agonist and PGE2 was reversed at low agonist concentrations, resulting in enhanced IL-13, but not IFN-gamma or IL-2, production. Dinoprostone 82-86 interferon gamma Homo sapiens 168-177 16530515-6 2006 RESULTS: Agonist-stimulated chloride secretion was inhibited by IFN-gamma, an effect prevented by ST/LA or BT. Chlorides 28-36 interferon gamma Homo sapiens 64-73 16537848-12 2006 Treatment with AM3 significantly restored the PBMC proliferative response to polyclonal mitogens and significantly promoted stimulated IFN-gamma production in these patients. Immunoferon 15-18 interferon gamma Homo sapiens 135-144 16487246-4 2006 IFNgamma added prior to infection of mouse peritoneal macrophages with IgA-opsonized bacilli resulted in a synergistic increase of nitric oxide and TNFalpha production and a 2-3 fold decrease in bacterial counts. Nitric Oxide 131-143 interferon gamma Homo sapiens 0-8 16496340-4 2006 HRC 203 had greater anti-viral activity on both isolated hepatocytes and macrophages, whereas both ribavirin and HRC 203 inhibited production of the pro-inflammatory cytokines interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) by macrophages. Ribavirin 99-108 interferon gamma Homo sapiens 176-203 16495555-2 2006 Enterohemorrhagic Escherichia coli (EHEC) modulates host cell signal transduction to establish infection, and EHEC serotypes O113:H21 and O157:H7 both inhibit IFN-gamma-induced Stat1 tyrosine phosphorylation in vitro. Tyrosine 183-191 interferon gamma Homo sapiens 159-168 16481346-6 2006 Blockade of MRP1 with the specific inhibitor MK-571 abrogated superantigen-induced expression of IFN-gamma, tumor necrosis factor-alpha, IL-10, IL-2, IL-4 and CD69 by T cells without affecting their viability, and was reversible upon removal of MK-571 from the culture media. verlukast 45-51 interferon gamma Homo sapiens 97-135 16495555-6 2006 The data showed that IFN-gamma-inducible Stat1 tyrosine phosphorylation was inhibited when EHEC adhered to T84 cells, but not by bacterial culture supernatants or bacteria separated from the epithelial monolayer. Tyrosine 47-55 interferon gamma Homo sapiens 21-30 16481346-6 2006 Blockade of MRP1 with the specific inhibitor MK-571 abrogated superantigen-induced expression of IFN-gamma, tumor necrosis factor-alpha, IL-10, IL-2, IL-4 and CD69 by T cells without affecting their viability, and was reversible upon removal of MK-571 from the culture media. verlukast 245-251 interferon gamma Homo sapiens 97-135 17058806-8 2006 SB203580, a specific inhibitor of p38 MAPK, markedly inhibited TNF-alpha- or IFN-gamma-induced IL-12-production either in the absence or presence of LPS, but showed only modest effects on IL-beta-induced IL-12-production. SB 203580 0-8 interferon gamma Homo sapiens 77-86 16563325-11 2006 The addition of IFN-gamma decreased HLA expression in presence of highest concentration of HES and dextran. Dextrans 99-106 interferon gamma Homo sapiens 16-25 16493073-8 2006 In a more generalized model of inflammation, delayed-type hypersensitivity, CP-481,715 significantly inhibited footpad swelling and decreased the amount of IFN-gamma and IL-2 produced by isolated spleen cells from sensitized animals. cp-481 76-82 interferon gamma Homo sapiens 156-165 16493032-7 2006 Cells stimulated in the continuous presence of 5 microM DMNQ, displayed a marked up-regulation in Th2 cytokines, including IL-4, IL-5, and IL-13, but not the Th1 cytokine IFN-gamma. 2,3-dimethoxy-1,4-naphthoquinone 56-60 interferon gamma Homo sapiens 171-180 16387840-7 2006 CD56+natural killer cells, CD56+T cells, and CD57+T cells (NK-T cells), which age-dependently increased in PBMC, produced much larger amounts of IFN-gamma after IL-12 priming than that of conventional CD56-CD57-T cells and also induced cocultured macrophages to produce TNF by subsequent LPS stimulation. lps 288-291 interferon gamma Homo sapiens 145-154 16574621-6 2006 In contrast, TCDD exposure enhanced the innate immune responses in offspring of both sexes; specifically, neutrophilia and interferon (IFN) gamma levels in the lung were increased. Polychlorinated Dibenzodioxins 13-17 interferon gamma Homo sapiens 123-145 16129490-8 2006 Interestingly, the significant damping effect of triptolide on B7-H1 signal could promote interleukin-2 production by T cell hybridoma (C10) after antigen presentation and enhance cytokine (IFN-gamma and IL-2) secretion by anti-CD3 activated T cells. triptolide 49-59 interferon gamma Homo sapiens 190-199 16630108-6 2006 In addition, interleukin-1beta and interferon-gamma exerted a proliferative effect on HPMC. hydroxypropylmethylcellulose-lactose matrix 86-90 interferon gamma Homo sapiens 35-51 16095896-5 2006 Furthermore, after attaching to silica nanoparticles, bovine serum albumin (BSA) maintains its major structure and the cytokine IFN-gamma maintains its ability to bind to its antibody. Silicon Dioxide 32-38 interferon gamma Homo sapiens 128-137 16495804-10 2006 Circulating interferon-gamma was reduced by CsA, but inhibition was dramatic with SRL alone or combined with CsA. Cyclosporine 44-47 interferon gamma Homo sapiens 12-28 16495804-12 2006 CONCLUSIONS: SRL plus CsA prevented allograft arteriopathy, correlating with suppression of intragraft interferon-gamma, suggesting that SRL effects may result from anti-inflammatory consequences from inhibiting interferon-gamma. Cyclosporine 22-25 interferon gamma Homo sapiens 103-119 16495808-8 2006 Splenocytes from mice treated with CsA after skin transplants had no response to third-party alloantigen, but showed an effector/memory pattern of IFN-gamma elaboration with donor cell stimulation (immunosuppression), although the IFN-gamma levels were not as high as those mice with unmodified graft rejection. Cyclosporine 35-38 interferon gamma Homo sapiens 231-240 16413531-7 2006 Furthermore, the data demonstrated (S)-armepavine impaired IL-2 and IFN-gamma transcripts in human peripheral blood mononuclear cells. armepavine 35-49 interferon gamma Homo sapiens 68-77 16359688-4 2006 In this assay, the anti-IFN-gamma monoclonal antibody labeled with fluorescein isothiocyanate (Ab*) was introduced into NK cells by electrophoration for intracellular immuno-reaction. Fluorescein-5-isothiocyanate 67-93 interferon gamma Homo sapiens 24-33 16337499-8 2006 Interferon-gamma and TNF-alpha were measured in conditioned medium obtained from the cultured PMBC upon priming with cardiac myosin. pmbc 94-98 interferon gamma Homo sapiens 0-16 16467537-5 2006 Furthermore, treatment with ACM suppressed interferon-gamma (IFN-gamma)-induced ROS production, leading to reduced inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) release. Reactive Oxygen Species 80-83 interferon gamma Homo sapiens 43-70 16467537-5 2006 Furthermore, treatment with ACM suppressed interferon-gamma (IFN-gamma)-induced ROS production, leading to reduced inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) release. Nitric Oxide 125-137 interferon gamma Homo sapiens 43-70 16467537-6 2006 In agreement with these results, mimickers of HO-1 products, such as bilirubin, ferrous iron, and a carbon monoxide-releasing molecule, reduced IFN-gamma-induced iNOS expression and/or NO release. Bilirubin 69-78 interferon gamma Homo sapiens 144-153 16467537-6 2006 In agreement with these results, mimickers of HO-1 products, such as bilirubin, ferrous iron, and a carbon monoxide-releasing molecule, reduced IFN-gamma-induced iNOS expression and/or NO release. Iron 88-92 interferon gamma Homo sapiens 144-153 16467537-6 2006 In agreement with these results, mimickers of HO-1 products, such as bilirubin, ferrous iron, and a carbon monoxide-releasing molecule, reduced IFN-gamma-induced iNOS expression and/or NO release. Carbon Monoxide 100-115 interferon gamma Homo sapiens 144-153 16162660-0 2006 Interferon-gamma activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells. Superoxides 95-111 interferon gamma Homo sapiens 0-16 16162660-2 2006 We report that interferon (IFN)-gamma, a crucial transactivator of the gp91(phox) gene, also stimulates expression of Nox1 mRNA and protein in large intestinal epithelium (T84 cells), leading to fourfold upregulation of superoxide anion (O(2)(-)) generation. Superoxides 220-236 interferon gamma Homo sapiens 15-37 16139256-4 2006 Tryptophan depletion via IDO is part of the cytostatic and antiproliferative activity mediated by interferon-gamma in cells. Tryptophan 0-10 interferon gamma Homo sapiens 98-114 16162660-2 2006 We report that interferon (IFN)-gamma, a crucial transactivator of the gp91(phox) gene, also stimulates expression of Nox1 mRNA and protein in large intestinal epithelium (T84 cells), leading to fourfold upregulation of superoxide anion (O(2)(-)) generation. Superoxides 238-242 interferon gamma Homo sapiens 15-37 16162660-7 2006 IFN-gamma caused tyrosine phosphorylation of signal transducer and activator of transcription 1 (STAT1) and produced a protein-GAS complex that was recognized by anti-STAT1 antibody. Tyrosine 17-25 interferon gamma Homo sapiens 0-9 16162660-9 2006 A Janus protein tyrosine kinase 2 inhibitor (AG490) blocked the IFN-gamma-stimulated tyrosine phosphorylation of STAT1, promoter activity of the -4,831 to +195 bp region, Nox1 mRNA expression, and O(2)(-) production, also suggesting a crucial role of STAT1 and GAS in the IFN-gamma-stimulated transcription of the Nox1 gene. Tyrosine 16-24 interferon gamma Homo sapiens 64-73 16399626-6 2006 Cortisol alone and in combination with GH Ab decreased CD4+ and CD8+ cells producing IFN-gamma, TNF-alpha and IL-2. gh ab 39-44 interferon gamma Homo sapiens 85-94 16430719-0 2006 Increase of interferon-gamma-inducible CXC chemokine CXCL10 serum levels in patients with active Graves" disease, and modulation by methimazole therapy. Methimazole 132-143 interferon gamma Homo sapiens 12-28 16495772-4 2006 Azelnidipine and other Ca2+-channel blockers inhibited the release of nitric oxide induced by lipopolysaccharide plus interferon-gamma. azelnidipine 0-12 interferon gamma Homo sapiens 118-134 16431966-0 2006 Glucosamine sulfate inhibits TNF-alpha and IFN-gamma-induced production of ICAM-1 in human retinal pigment epithelial cells in vitro. Glucosamine 0-19 interferon gamma Homo sapiens 43-52 16495772-4 2006 Azelnidipine and other Ca2+-channel blockers inhibited the release of nitric oxide induced by lipopolysaccharide plus interferon-gamma. Nitric Oxide 70-82 interferon gamma Homo sapiens 118-134 16424161-4 2006 Although T cells did not respond directly to poly(I:C), we observed a dramatic increase in IFN-gamma secretion and an up-regulation of CD69 when freshly isolated gammadelta T cells were stimulated via TCR in the presence of poly(I:C) without APC. Poly I-C 224-232 interferon gamma Homo sapiens 91-100 16303841-9 2006 Treatment of all cell types with the PPARgamma agonist, rosiglitazone, dose-dependently (0.1-10 microm) suppressed IFNgamma- plus TNFalpha-induced CXCL10 release. Rosiglitazone 56-69 interferon gamma Homo sapiens 115-123 16317060-8 2006 PBMC responsiveness was evaluated by cytokine release and proliferation after stimulation with phytohemagglutinin, phytohemagglutinin plus IL-12, lipopolysaccharide, and lipopolysaccharide plus interferon-gamma at baseline and 4 months. PBMC 0-4 interferon gamma Homo sapiens 194-210 16291871-5 2006 We also found that TNFalpha and IFNgamma impaired GC responsiveness by inhibiting steroid induced both 1) GRalpha-DNA binding activity and 2) GC-responsive element-(GRE)-dependent gene transcription. Steroids 82-89 interferon gamma Homo sapiens 32-40 16467399-5 2006 In JAR cells, etoposide increased expression of the proteins including IFNgammaR, p53 and pro-caspase 3 as well as IRF-1 mRNA and IFNgamma-pretreatment apparently promoted up-regulation of these molecules expression. Etoposide 14-23 interferon gamma Homo sapiens 71-79 16267208-0 2006 Activation and potentiation of interferon-gamma signaling by 3,3"-diindolylmethane in MCF-7 breast cancer cells. 3,3'-diindolylmethane 61-82 interferon gamma Homo sapiens 31-47 16467399-7 2006 IRF-1 knock down assays demonstrated that IRF-1 directly mediated IFNgamma pretreatment enhanced sensitivity of JAR cells to etoposide-induced apoptosis and that pro-caspase 3 was one of the target genes of IRF-1. Etoposide 125-134 interferon gamma Homo sapiens 66-74 16426249-3 2006 Thus, the determination of neopterin concentrations is an indirect measure of the levels of IFN-gamma and allows us to monitor Th1-type immune response. Neopterin 27-36 interferon gamma Homo sapiens 92-101 16467399-0 2006 IFNgamma pretreatment sensitizes human choriocarcinoma cells to etoposide-induced apoptosis. Etoposide 64-73 interferon gamma Homo sapiens 0-8 16380292-2 2006 Now, however, a ligand-independent mechanism of IFNgammaR2 internalization is emerging as a more general way of limiting IFNgamma-STAT1 signaling in T cells, with insulin-like growth factor-1 (IGF-1) and iron as the main players. Iron 204-208 interferon gamma Homo sapiens 121-135 16390542-5 2006 In vivo administration of siRNA admixed with the oil-based contrast agent lipiodol in the presence of antigen and adjuvant induced a deviation in recall response to reduced production of IFN-gamma and augmented IL-4 response using either KLH or ovalbumin. Oils 49-52 interferon gamma Homo sapiens 187-196 16505600-3 2006 iNKT cells recognize glycolipid antigens such as alpha-galactosylceramide (alpha-GC) presented by CD1d, non-pormorphic MHC class I-like molecule, and rapidly secrete large amounts of cytokines including IL-4 and IFN-gamma upon activation. Glycolipids 21-31 interferon gamma Homo sapiens 212-221 16505600-3 2006 iNKT cells recognize glycolipid antigens such as alpha-galactosylceramide (alpha-GC) presented by CD1d, non-pormorphic MHC class I-like molecule, and rapidly secrete large amounts of cytokines including IL-4 and IFN-gamma upon activation. alpha-galactosylceramide 49-73 interferon gamma Homo sapiens 212-221 16505600-3 2006 iNKT cells recognize glycolipid antigens such as alpha-galactosylceramide (alpha-GC) presented by CD1d, non-pormorphic MHC class I-like molecule, and rapidly secrete large amounts of cytokines including IL-4 and IFN-gamma upon activation. alpha-galactosylceramide 75-83 interferon gamma Homo sapiens 212-221 16390542-5 2006 In vivo administration of siRNA admixed with the oil-based contrast agent lipiodol in the presence of antigen and adjuvant induced a deviation in recall response to reduced production of IFN-gamma and augmented IL-4 response using either KLH or ovalbumin. Ethiodized Oil 74-82 interferon gamma Homo sapiens 187-196 15871904-6 2006 In human ASMCs, IFNgamma again stimulated a transient STAT1-binding to the PDGF-Ralpha promoter. asmcs 9-14 interferon gamma Homo sapiens 16-24 16889669-6 2006 Catecholamines inhibited the synthesis of IFN-gamma, TNF-alpha, and IL-10 at a concentration of 10(-5) M. In addition, IFN-gamma release was suppressed by 10(-7) M epinephrine. Catecholamines 0-14 interferon gamma Homo sapiens 42-51 16889669-6 2006 Catecholamines inhibited the synthesis of IFN-gamma, TNF-alpha, and IL-10 at a concentration of 10(-5) M. In addition, IFN-gamma release was suppressed by 10(-7) M epinephrine. Catecholamines 0-14 interferon gamma Homo sapiens 119-128 16889669-6 2006 Catecholamines inhibited the synthesis of IFN-gamma, TNF-alpha, and IL-10 at a concentration of 10(-5) M. In addition, IFN-gamma release was suppressed by 10(-7) M epinephrine. Epinephrine 164-175 interferon gamma Homo sapiens 42-51 16889669-6 2006 Catecholamines inhibited the synthesis of IFN-gamma, TNF-alpha, and IL-10 at a concentration of 10(-5) M. In addition, IFN-gamma release was suppressed by 10(-7) M epinephrine. Epinephrine 164-175 interferon gamma Homo sapiens 119-128 16889669-9 2006 The inhibitory effect of catecholamines on IFN-gamma production was lower in RA patients as compared with HDs. Catecholamines 25-39 interferon gamma Homo sapiens 43-52 16889669-14 2006 RA patients demonstrate an impaired inhibitory effect of catecholamines on IFN-gamma production together with a failure to induce a shift of T-cell cytokine responses toward a Th2-like profile. Catecholamines 57-71 interferon gamma Homo sapiens 75-84 16397210-4 2006 The interaction of fAChRzeta-transduced T cells with fAChR-positive rhabdomyosarcoma cell lines, but not with fAChR-negative control cells, induced T-cell activation characterized by strong secretion of IFN-gamma and delayed lysis of tumor cells. fachrzeta 19-28 interferon gamma Homo sapiens 203-212 16864989-0 2006 Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2). 15-deoxy-delta(12,14)-prostaglandin J2 10-18 interferon gamma Homo sapiens 67-76 16210363-5 2006 We report here that interferon-gamma and IL-4, representative of these respective classes of cytokines, attenuate IL-1beta-provoked PGE2 production. Dinoprostone 132-136 interferon gamma Homo sapiens 20-36 16210363-9 2006 The actions of interferon-gamma and IL-4 are mediated through the Janus kinase 2/signal transducer and activator of transcription signaling pathway and could be abolished by treating with AG490, a specific inhibitor of Janus kinase 2. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 188-193 interferon gamma Homo sapiens 15-31 16210363-10 2006 In contrast, the up-regulation of hyaluronan synthesis by IL-1beta is enhanced by either IL-4 or interferon-gamma. Hyaluronic Acid 34-44 interferon gamma Homo sapiens 97-113 16510923-6 2006 Miltefosine is able to change immunological reactions to enhance the immune response of interleukin-2-stimulating mononuclear cells, resulting in interferon gamma gene expression and interferon gamma secretion. miltefosine 0-11 interferon gamma Homo sapiens 146-162 17974159-5 2006 Additionally, a significant suppression of IFN-gamma production was demonstrated in the presence of naloxone. Naloxone 100-108 interferon gamma Homo sapiens 43-52 16510923-6 2006 Miltefosine is able to change immunological reactions to enhance the immune response of interleukin-2-stimulating mononuclear cells, resulting in interferon gamma gene expression and interferon gamma secretion. miltefosine 0-11 interferon gamma Homo sapiens 183-199 17113915-5 2006 Increased neopterin concentrations as well as accelerated tryptophan degradation have been found to predict poor prognosis in patients with cancer, and both these immunobiochemical pathways are induced by the pro-inflammatory cytokine interferon-gamma. Neopterin 10-19 interferon gamma Homo sapiens 235-251 16374867-3 2006 We found that the type II transcriptional response to IFN-gamma could be suppressed by inhibition of MEK1/2 kinase activity by MEK1/2 inhibitor U0126 in the hepatoma cell line Huh-7. U 0126 144-149 interferon gamma Homo sapiens 54-63 16741367-3 2006 OBJECTIVE: In this study the capacity of desloratadine and loratadine to counteract human keratinocyte activation by interferon-gamma (IFN-gamma) was analyzed. desloratadine 41-54 interferon gamma Homo sapiens 117-133 16423039-3 2006 We determined that ISS-induced IFN-gamma from NK cells is primarily dependent upon IFN-alpha release from plasmacytoid dendritic cells (PDCs), which directly activates the NK cell. ISS 19-22 interferon gamma Homo sapiens 31-40 16691030-10 2006 Immunohistochemical analysis in 2 patients revealed an induction of interferon-gamma in primecrolimus-pretreated skin. primecrolimus 88-101 interferon gamma Homo sapiens 68-84 16741367-7 2006 RESULTS: Desloratadine and loratadine inhibited the constitutive and IFN-gamma-induced release of CCL5, CXCL8 and CXCL10 from keratinocytes, while the low release of CCL17 remained unchanged. desloratadine 9-22 interferon gamma Homo sapiens 69-78 16741367-3 2006 OBJECTIVE: In this study the capacity of desloratadine and loratadine to counteract human keratinocyte activation by interferon-gamma (IFN-gamma) was analyzed. desloratadine 41-54 interferon gamma Homo sapiens 135-144 16741367-7 2006 RESULTS: Desloratadine and loratadine inhibited the constitutive and IFN-gamma-induced release of CCL5, CXCL8 and CXCL10 from keratinocytes, while the low release of CCL17 remained unchanged. Loratadine 12-22 interferon gamma Homo sapiens 69-78 16741367-9 2006 CONCLUSIONS: The results indicate that desloratadine has the capacity to block the IFN-gamma-induced activation of keratinocytes, and that it can thus exert important regulatory effects on cell-mediated immune responses in the skin. desloratadine 39-52 interferon gamma Homo sapiens 83-92 16741367-3 2006 OBJECTIVE: In this study the capacity of desloratadine and loratadine to counteract human keratinocyte activation by interferon-gamma (IFN-gamma) was analyzed. Loratadine 44-54 interferon gamma Homo sapiens 117-133 16741367-3 2006 OBJECTIVE: In this study the capacity of desloratadine and loratadine to counteract human keratinocyte activation by interferon-gamma (IFN-gamma) was analyzed. Loratadine 44-54 interferon gamma Homo sapiens 135-144 16804321-6 2006 Furthermore CD4+ suxamethonium-reactive T cell lines were IFN-gamma-positive and synthesized high levels of IFN-gamma and TNF-alpha. Succinylcholine 17-30 interferon gamma Homo sapiens 58-67 16804321-0 2006 Delayed allergic reaction to suxamethonium driven by oligoclonal Th1-skewed CD4+CCR4+IFN-gamma+ memory T cells. Succinylcholine 29-42 interferon gamma Homo sapiens 85-94 16804321-6 2006 Furthermore CD4+ suxamethonium-reactive T cell lines were IFN-gamma-positive and synthesized high levels of IFN-gamma and TNF-alpha. Succinylcholine 17-30 interferon gamma Homo sapiens 108-117 16445639-2 2006 Among other biochemical indicators of systemic immune and inflammatory activity, activation of macrophages by interferon-gamma induces a marked increase in the production of neopterin. Neopterin 174-183 interferon gamma Homo sapiens 110-126 16355272-1 2006 UNLABELLED: Monocytes express 1alpha-hydroxylase, the enzyme responsible for final hydroxylation of vitamin D3, in response to IFNgamma and CD14/TLR4 activation. Cholecalciferol 100-110 interferon gamma Homo sapiens 127-135 16365409-10 2006 LPS- plus IFN-gamma-induced activation of DCs (assessed by CD40 expression) was observed when there was cell-to-cell contact and was significantly blocked by heptanol, a gap junction blocker. Heptanol 158-166 interferon gamma Homo sapiens 10-19 16365409-12 2006 In addition, heptanol significantly inhibited the LPS- plus IFN-gamma-induced up-regulation of the other costimulatory (i.e., CD80 and CD86) and MHC class II molecules expressed by BMDCs, and it significantly reduced their allostimulatory capacity. Heptanol 13-21 interferon gamma Homo sapiens 60-69 16365430-1 2006 IDO induction can deplete L-tryptophan in target cells, an effect partially responsible for the antimicrobial activities and antiallogeneic T cell responses of IFN-gamma in human macrophages, dendritic cells, and bone marrow cells. Tryptophan 26-38 interferon gamma Homo sapiens 160-169 16365430-3 2006 In this study we found that IDO activity was inhibited by the peroxynitrite generator, 3-(4-morpholinyl)sydnonimine, in PMA-differentiated cytokine-induced THP-1 (acute monocytic leukemia) cells and IFN-gamma-stimulated PBMCs, whereas IDO protein expression was unaffected compared with that in untreated cells. Peroxynitrous Acid 62-75 interferon gamma Homo sapiens 199-208 16307444-5 2006 Moreover, the NADPH oxidase inhibitors apocynin and diphenylene iodonium were protective against IFN-gamma/LPS cytotoxicity only at concentrations that suppressed nitric oxide production. acetovanillone 39-47 interferon gamma Homo sapiens 97-106 16307444-0 2006 c-Jun N-terminal kinase inhibition and alpha-tocopherol protect midbrain dopaminergic neurons from interferon-gamma/lipopolysaccharide-induced injury without affecting nitric oxide production. alpha-Tocopherol 39-55 interferon gamma Homo sapiens 99-115 16307444-1 2006 Interferon-gamma (IFN-gamma)/lipopolysaccharide (LPS) induces delayed dopaminergic neuron loss in midbrain slice cultures, because of nitric oxide production resulting from p38 mitogen-activated protein kinase (p38 MAPK)-dependent induction of inducible nitric oxide synthase (iNOS). Nitric Oxide 134-146 interferon gamma Homo sapiens 0-16 16307444-1 2006 Interferon-gamma (IFN-gamma)/lipopolysaccharide (LPS) induces delayed dopaminergic neuron loss in midbrain slice cultures, because of nitric oxide production resulting from p38 mitogen-activated protein kinase (p38 MAPK)-dependent induction of inducible nitric oxide synthase (iNOS). Nitric Oxide 134-146 interferon gamma Homo sapiens 18-27 16307444-5 2006 Moreover, the NADPH oxidase inhibitors apocynin and diphenylene iodonium were protective against IFN-gamma/LPS cytotoxicity only at concentrations that suppressed nitric oxide production. diphenyleneiodonium 52-72 interferon gamma Homo sapiens 97-106 16307444-5 2006 Moreover, the NADPH oxidase inhibitors apocynin and diphenylene iodonium were protective against IFN-gamma/LPS cytotoxicity only at concentrations that suppressed nitric oxide production. Nitric Oxide 163-175 interferon gamma Homo sapiens 97-106 16307444-6 2006 Notably, alpha-tocopherol effectively prevented IFN-gamma/LPS-induced dopaminergic neuron degeneration, without affecting iNOS induction and nitric oxide production. alpha-Tocopherol 9-25 interferon gamma Homo sapiens 48-57 16490927-7 2006 The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells. Tetradecanoylphorbol Acetate 20-45 interferon gamma Homo sapiens 201-217 16485704-5 2006 In addition, the prepared column was first used in the purification and simultaneous renaturation of recombinant human interferon gamma (rhIFN-gamma) in the extract solution with 7.0 mol/L guanidine hydrochloride. Guanidine 189-212 interferon gamma Homo sapiens 119-148 16490927-7 2006 The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells. Tetradecanoylphorbol Acetate 20-45 interferon gamma Homo sapiens 219-228 16490927-7 2006 The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells. Tetradecanoylphorbol Acetate 47-50 interferon gamma Homo sapiens 201-217 16490927-7 2006 The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells. Tetradecanoylphorbol Acetate 47-50 interferon gamma Homo sapiens 219-228 16490927-8 2006 In addition, both Go6976 and Rottlerin inhibited the up-regulation of CD93 expression induced by PMA and IL-8 or IFN-gamma production in the respective cell-lines. Go 6976 18-24 interferon gamma Homo sapiens 113-122 16490927-8 2006 In addition, both Go6976 and Rottlerin inhibited the up-regulation of CD93 expression induced by PMA and IL-8 or IFN-gamma production in the respective cell-lines. rottlerin 29-38 interferon gamma Homo sapiens 113-122 16467767-3 2006 Stimulated PBMCs were incubated in CO(2) for production of interferon-gamma (IFN-gamma), which was measured from the supernatant of cultured PBMCs by an in-house ELISA technique. co(2) 35-40 interferon gamma Homo sapiens 59-75 16467767-3 2006 Stimulated PBMCs were incubated in CO(2) for production of interferon-gamma (IFN-gamma), which was measured from the supernatant of cultured PBMCs by an in-house ELISA technique. co(2) 35-40 interferon gamma Homo sapiens 77-86 16615178-15 2006 dGMP completely inhibited virus-triggered IFN-gamma secretion, whereas TMP did not change the virus induced secretion pattern of measured cytokines. 2'-deoxyguanosine 5'-phosphate 0-4 interferon gamma Homo sapiens 42-51 16282703-9 2006 Co-cultured experiments revealed that TEC-related B7-H1 was identified as a strong inhibitor of CD4+ T-cell activation as assessed by increased cytokine production (interleukin-2 and interferon-gamma) and expression levels of the T cell activation marker (CD69) in the presence of a neutralizing antibody against B7-H1 (clone MIH1). Turpentine 38-41 interferon gamma Homo sapiens 183-199 17152808-6 2006 Blood sample was obtained from patients and examined for the expression of Interleukin 2, 4, and 13 and IFN-gamma by intracellular staining procedure after stimulation with PMA/ionomycin (phorbol 12-myristate 13-acetate) and allergen (D. pteronyssimus, Allergopharma). Tetradecanoylphorbol Acetate 173-176 interferon gamma Homo sapiens 104-113 17152808-6 2006 Blood sample was obtained from patients and examined for the expression of Interleukin 2, 4, and 13 and IFN-gamma by intracellular staining procedure after stimulation with PMA/ionomycin (phorbol 12-myristate 13-acetate) and allergen (D. pteronyssimus, Allergopharma). Ionomycin 177-186 interferon gamma Homo sapiens 104-113 17152808-6 2006 Blood sample was obtained from patients and examined for the expression of Interleukin 2, 4, and 13 and IFN-gamma by intracellular staining procedure after stimulation with PMA/ionomycin (phorbol 12-myristate 13-acetate) and allergen (D. pteronyssimus, Allergopharma). Tetradecanoylphorbol Acetate 188-219 interferon gamma Homo sapiens 104-113 17867605-6 2006 The interaction of fAChzeta-transduced T cells with several RMS cell lines but not with fAChR-negative controls induced strong T cell activation, characterized by secretion of high amounts of interferon-gamma. fachzeta 19-27 interferon gamma Homo sapiens 192-208 17642139-11 2006 The concentration of IFNgamma in supernatants from stimulated as well as non-stimulated cells from patients with contact allergy to nickel was higher in comparison to the control group. Nickel 132-138 interferon gamma Homo sapiens 21-29 17642139-13 2006 There was an increase in the production of IFNgamma and IL-5 after NiSO4 stimulation in patients with systemic allergy to nickel. nickel sulfate 67-72 interferon gamma Homo sapiens 43-51 17642139-13 2006 There was an increase in the production of IFNgamma and IL-5 after NiSO4 stimulation in patients with systemic allergy to nickel. Nickel 122-128 interferon gamma Homo sapiens 43-51 17642139-16 2006 SUMMARY: IFNgamma plays an essential role in the mechanism of developing of contact allergy to nickel; and IFNgamma as well as IL-5 play a role in the mechanism of developing systemic allergy to nickel. Nickel 95-101 interferon gamma Homo sapiens 9-17 17642139-16 2006 SUMMARY: IFNgamma plays an essential role in the mechanism of developing of contact allergy to nickel; and IFNgamma as well as IL-5 play a role in the mechanism of developing systemic allergy to nickel. Nickel 195-201 interferon gamma Homo sapiens 107-115 16388738-8 2006 CPLA enhanced IL-12 and IFN-gamma production by DCs (P<0.05). cpla 0-4 interferon gamma Homo sapiens 24-33 16257975-0 2005 The conserved Leu-724 residue is required for both serine phosphorylation and co-activator recruitment for Stat1-mediated transcription activation in response to interferon-gamma. Leucine 14-17 interferon gamma Homo sapiens 162-178 16624084-5 2006 CD(4)(+) CD(25)(+) Treg cells highly expressed Foxp3 and mainly synthesized IL-10; CD(4)(+) CD(25)(+) Treg cells dramatically suppressed the proliferation of CD(4)(+) T cells and the production of IFN gamma; the suppressive activity of CD(4)(+) CD(25)(+) Treg cells in patients with persistent HCV-infection was higher than that in healthy controls (P = 0.034). Cadmium 0-2 interferon gamma Homo sapiens 197-206 16257975-0 2005 The conserved Leu-724 residue is required for both serine phosphorylation and co-activator recruitment for Stat1-mediated transcription activation in response to interferon-gamma. Serine 51-57 interferon gamma Homo sapiens 162-178 16257975-8 2005 Our results demonstrate that the conserved Leu-724 residue is a key residue that controls the maximal transcription activities of Stat1 in IFN-gamma signaling. Leucine 43-46 interferon gamma Homo sapiens 139-148 16325157-2 2005 Nicergoline, an ergoline derivative, significantly suppressed the neuronal cell death induced by co-culture with activated microglia or astrocytes stimulated with lipopolysaccharide (LPS) and interferon (IFN)-gamma. Nicergoline 0-11 interferon gamma Homo sapiens 192-214 16325157-2 2005 Nicergoline, an ergoline derivative, significantly suppressed the neuronal cell death induced by co-culture with activated microglia or astrocytes stimulated with lipopolysaccharide (LPS) and interferon (IFN)-gamma. Ergolines 3-11 interferon gamma Homo sapiens 192-214 16325157-4 2005 In microglia stimulated with LPS and IFN-gamma, nicergoline suppressed the production of superoxide anions, interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha in a dose-dependent manner. Nicergoline 48-59 interferon gamma Homo sapiens 37-46 16259956-5 2005 During DC differentiation in the presence of apoA-I, PGE(2) and IL-10, which are known to be DC differentiation inhibitors and/or modulators of DC function, were produced at remarkable rates, whereas IL-12 production in the cells after stimulation with CD40 mAb and IFN-gamma was significantly decreased in comparison with the control DC. Prostaglandins E 53-56 interferon gamma Homo sapiens 266-275 16357824-2 2005 This test detects the release of interferon-gamma (IFN-g) in fresh heparinized whole blood from sensitized persons when it is incubated with mixtures of synthetic peptides representing two proteins present in M. tuberculosis: early secretory antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10). Peptides 163-171 interferon gamma Homo sapiens 33-49 16357824-2 2005 This test detects the release of interferon-gamma (IFN-g) in fresh heparinized whole blood from sensitized persons when it is incubated with mixtures of synthetic peptides representing two proteins present in M. tuberculosis: early secretory antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10). Peptides 163-171 interferon gamma Homo sapiens 51-56 16118315-0 2005 1alpha,25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation. Calcitriol 0-29 interferon gamma Homo sapiens 56-72 16118315-4 2005 We show here that 1alpha,25(OH)2D3 can selectively suppress key effector functions of IFN-gamma-activated macrophages. 25(oh)2d3 25-34 interferon gamma Homo sapiens 86-95 16118315-6 2005 The deactivation of IFN-gamma-stimulated macrophages is dependent on a functional vitamin D receptor and 1alpha,25(OH)2D3 acts specifically on IFN-gamma-activated macrophages, whereas the steroid has no effects on resting macrophages. Steroids 188-195 interferon gamma Homo sapiens 20-29 16298681-5 2005 Treatment of HT-29 cells with conditioned medium from IFN-gamma/LPS-stimulated MMC produced significant amounts of NO, which suggested the presence of an MMC-derived soluble factor modifying epithelial NO production. Mitomycin 79-82 interferon gamma Homo sapiens 54-63 16263092-7 2005 However, only the ceramide-like compound PDMP inhibited the expression of activation markers and the secretion of IFN-gamma which was not seen with myriocin treatment. Ceramides 18-26 interferon gamma Homo sapiens 114-123 16298681-7 2005 Interestingly, pretreatment of HT-29 cells with IL-1 receptor antagonist suppressed the IFN-gamma/LPS-stimulated MMC-induced NO production. Mitomycin 113-116 interferon gamma Homo sapiens 88-97 16118322-6 2005 We demonstrate also that ATP significantly potentiates the up-regulation of IDO--a negative regulator of T lymphocyte proliferation--and kynurenine production initiated by interferon-gamma (IFN-gamma) in human DCs. Adenosine Triphosphate 25-28 interferon gamma Homo sapiens 172-188 16343349-5 2005 METHODS: In this study, we investigated the effects of a cannabinoid agonist on CD40 expression and function by cultured microglial cells activated by IFN-gamma using RT-PCR, Western immunoblotting, flow cytometry, and anti-CB2 small interfering RNA (siRNA) analyses. Cannabinoids 57-68 interferon gamma Homo sapiens 151-160 16343349-7 2005 RESULTS: We found that the selective stimulation of cannabinoid receptor CB2 by JWH-015 suppressed IFN-gamma-induced CD40 expression. JHW 015 80-87 interferon gamma Homo sapiens 99-108 16343349-9 2005 Further, this stimulation was also able to suppress microglial TNF-alpha and nitric oxide production induced either by IFN-gamma or Abeta peptide challenge in the presence of CD40 ligation. Nitric Oxide 77-89 interferon gamma Homo sapiens 119-128 16326428-1 2005 The molecular mechanism underlying the suppression of lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced nitric oxide (NO) and prostaglandin (PG) E(2) production was investigated in RAW 264.7 macrophages treated with sesquiterpene lactones, zaluzanin-C and estafiatone, isolated from Ainsliaea. Nitric Oxide 116-128 interferon gamma Homo sapiens 79-106 16326428-1 2005 The molecular mechanism underlying the suppression of lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced nitric oxide (NO) and prostaglandin (PG) E(2) production was investigated in RAW 264.7 macrophages treated with sesquiterpene lactones, zaluzanin-C and estafiatone, isolated from Ainsliaea. Dinoprostone 138-161 interferon gamma Homo sapiens 79-106 16326428-1 2005 The molecular mechanism underlying the suppression of lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced nitric oxide (NO) and prostaglandin (PG) E(2) production was investigated in RAW 264.7 macrophages treated with sesquiterpene lactones, zaluzanin-C and estafiatone, isolated from Ainsliaea. sesquiterpene lactones 228-250 interferon gamma Homo sapiens 79-106 16326428-1 2005 The molecular mechanism underlying the suppression of lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced nitric oxide (NO) and prostaglandin (PG) E(2) production was investigated in RAW 264.7 macrophages treated with sesquiterpene lactones, zaluzanin-C and estafiatone, isolated from Ainsliaea. zaluzanin C 252-263 interferon gamma Homo sapiens 79-106 16326428-1 2005 The molecular mechanism underlying the suppression of lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced nitric oxide (NO) and prostaglandin (PG) E(2) production was investigated in RAW 264.7 macrophages treated with sesquiterpene lactones, zaluzanin-C and estafiatone, isolated from Ainsliaea. estafiatone 268-279 interferon gamma Homo sapiens 79-106 16326428-2 2005 Zaluzanin-C and estafiatone decreased NO production in LPS/IFN-gamma-stimulated RAW 264.7 macrophages with an IC50 of about 6.61 microM and 3.80 microM, respectively. zaluzanin C 0-11 interferon gamma Homo sapiens 59-68 16326428-2 2005 Zaluzanin-C and estafiatone decreased NO production in LPS/IFN-gamma-stimulated RAW 264.7 macrophages with an IC50 of about 6.61 microM and 3.80 microM, respectively. estafiatone 16-27 interferon gamma Homo sapiens 59-68 16326428-3 2005 In addition, these compounds inhibited the synthesis of PGE(2) in LPS/IFN-gamma-treated RAW 264.7 macrophages. Prostaglandins E 56-59 interferon gamma Homo sapiens 70-79 16326428-5 2005 Zaluzanin-C and estafiatone inhibited nuclear factor-kappaB (NF-kappaB) activation, a transcription factor necessary for iNOS and COX-2 expression in response to LPS/IFN-gamma. zaluzanin C 0-11 interferon gamma Homo sapiens 166-175 16326428-5 2005 Zaluzanin-C and estafiatone inhibited nuclear factor-kappaB (NF-kappaB) activation, a transcription factor necessary for iNOS and COX-2 expression in response to LPS/IFN-gamma. estafiatone 16-27 interferon gamma Homo sapiens 166-175 16601779-3 2005 In contrast to PMEA, bis-POM-PMEA inhibited production of nitric oxide (NO) in macrophages activated with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). [[(1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate 21-33 interferon gamma Homo sapiens 106-122 16601779-3 2005 In contrast to PMEA, bis-POM-PMEA inhibited production of nitric oxide (NO) in macrophages activated with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). [[(1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate 21-33 interferon gamma Homo sapiens 124-133 16601779-3 2005 In contrast to PMEA, bis-POM-PMEA inhibited production of nitric oxide (NO) in macrophages activated with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). Nitric Oxide 58-70 interferon gamma Homo sapiens 106-122 16601779-3 2005 In contrast to PMEA, bis-POM-PMEA inhibited production of nitric oxide (NO) in macrophages activated with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). Nitric Oxide 58-70 interferon gamma Homo sapiens 124-133 16410947-6 2005 A trend towards a positive correlation was noted, with increasing percentage of NBT positive neutrophils and levels of IFN-gamma. Nitroblue Tetrazolium 80-83 interferon gamma Homo sapiens 119-128 16410947-7 2005 The high IFN-gamma producing HTLV-1 patient group had significantly greater NBT than healthy controls, 43+/-24% and 17+/-4.8% respectively (p< 0.001), while no significant difference was observed between healthy controls and the low IFN-gamma-producing HTLV-1 patient group (30+/-20%). Nitroblue Tetrazolium 76-79 interferon gamma Homo sapiens 9-18 16118322-6 2005 We demonstrate also that ATP significantly potentiates the up-regulation of IDO--a negative regulator of T lymphocyte proliferation--and kynurenine production initiated by interferon-gamma (IFN-gamma) in human DCs. Adenosine Triphosphate 25-28 interferon gamma Homo sapiens 190-199 16118322-6 2005 We demonstrate also that ATP significantly potentiates the up-regulation of IDO--a negative regulator of T lymphocyte proliferation--and kynurenine production initiated by interferon-gamma (IFN-gamma) in human DCs. Kynurenine 137-147 interferon gamma Homo sapiens 172-188 16118322-6 2005 We demonstrate also that ATP significantly potentiates the up-regulation of IDO--a negative regulator of T lymphocyte proliferation--and kynurenine production initiated by interferon-gamma (IFN-gamma) in human DCs. Kynurenine 137-147 interferon gamma Homo sapiens 190-199 15908180-8 2005 Collectively, these data demonstrate that TNF-alpha/IFN-gamma synergistically activates JNK/SAPK, playing an important role in promoting apoptosis of pancreatic beta-cell via activation of p53 pathway together with ROS. ros 215-218 interferon gamma Homo sapiens 52-61 15908180-0 2005 Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway. ros 122-125 interferon gamma Homo sapiens 60-69 16339068-1 2005 Previous studies have indicated that neopterin is synthesized in vitro by human monocyte-derived macrophages and dendritic cells upon stimulation with gamma interferon (IFN-gamma). Neopterin 37-46 interferon gamma Homo sapiens 151-178 15908180-3 2005 Additionally, cells transfected with wild-type JNK1 became more susceptible to apoptosis induced by TNF-alpha/IFN-gamma through ROS production and loss of delta psi m, while cascading apoptotic events were prevented in dominant-negative JNK1-transfected or JNK inhibitor SP600125-treated cells. ros 128-131 interferon gamma Homo sapiens 110-119 15908180-6 2005 Furthermore, the synergistic effect of TNF-alpha/IFN-gamma on apoptosis and ROS production was further potentiated by the overexpression of wild-type p53, but not with mutant p53. ros 76-79 interferon gamma Homo sapiens 49-58 15908180-7 2005 This synergistic activation of JNK/SAPK by TNF-alpha/IFN-gamma was also induced in insulin-expressing pancreatic islet cells, and increased ROS production and p53 level, which was significantly inhibited by SP600125. ros 140-143 interferon gamma Homo sapiens 53-62 15908180-7 2005 This synergistic activation of JNK/SAPK by TNF-alpha/IFN-gamma was also induced in insulin-expressing pancreatic islet cells, and increased ROS production and p53 level, which was significantly inhibited by SP600125. pyrazolanthrone 207-215 interferon gamma Homo sapiens 53-62 16339068-3 2005 However, it is unknown if any IFN-gamma-independent neopterin synthesis is possible in vivo. Neopterin 52-61 interferon gamma Homo sapiens 30-39 16339068-7 2005 We found that serum neopterin levels are elevated in the complete absence of IFN-gamma activity due either to a complete deficiency of its receptor or to deleterious mutations of IL-12 or its receptor. Neopterin 20-29 interferon gamma Homo sapiens 77-86 16266314-4 2005 The secretion of IL-2 and IFN-gamma was also significantly increased by pgD and pMIP-1alpha co-injection; however, the production of cytokines IL-4 and IL-10 was not affected by co-injection. pgd 72-75 interferon gamma Homo sapiens 26-35 15922660-7 2005 RESULTS: The ratio of IFN-gamma-producing T cells was significantly higher in AMI-C group (17.8% +/- 6.4%) than in the AMI patients treated with oral atorvastatin (AMI-A, 13.1% +/- 4.6%). ami-c 78-83 interferon gamma Homo sapiens 22-31 15922660-7 2005 RESULTS: The ratio of IFN-gamma-producing T cells was significantly higher in AMI-C group (17.8% +/- 6.4%) than in the AMI patients treated with oral atorvastatin (AMI-A, 13.1% +/- 4.6%). Atorvastatin 150-162 interferon gamma Homo sapiens 22-31 15922660-7 2005 RESULTS: The ratio of IFN-gamma-producing T cells was significantly higher in AMI-C group (17.8% +/- 6.4%) than in the AMI patients treated with oral atorvastatin (AMI-A, 13.1% +/- 4.6%). ami-a 164-169 interferon gamma Homo sapiens 22-31 16266314-4 2005 The secretion of IL-2 and IFN-gamma was also significantly increased by pgD and pMIP-1alpha co-injection; however, the production of cytokines IL-4 and IL-10 was not affected by co-injection. pmip-1alpha 80-91 interferon gamma Homo sapiens 26-35 16291659-7 2005 Furthermore, CpG oligodeoxynucleotide augmented IL-12 production when co-administrated with OCH, resulting in increased IFN-gamma production. Oligodeoxyribonucleotides 17-37 interferon gamma Homo sapiens 120-129 16239287-0 2005 Differential effects of beta-lactams on human IFN-gamma activity. beta-Lactams 24-36 interferon gamma Homo sapiens 46-55 16299289-4 2005 The stimulation of DCs with MDP and FK565 in combination with lipid A, poly(I:C), and CpG DNA, but not with Pam3CSSNA, synergistically induced interleukin-12 (IL-12) p70 and gamma interferon (IFN-gamma), but not IL-18, in culture supernatants and induced IL-15 on the cell surface. heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine 36-41 interferon gamma Homo sapiens 174-201 16299289-8 2005 The culture supernatants of DCs stimulated with lipid A plus either MDP or FK565 activated human T cells to produce high levels of IFN-gamma, and the activity was attributable to DC-derived IL-12. Lipid A 48-55 interferon gamma Homo sapiens 131-140 16299289-8 2005 The culture supernatants of DCs stimulated with lipid A plus either MDP or FK565 activated human T cells to produce high levels of IFN-gamma, and the activity was attributable to DC-derived IL-12. heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine 75-80 interferon gamma Homo sapiens 131-140 16239287-1 2005 OBJECTIVES: To investigate whether a range of beta-lactam antibiotics conjugate to and hence reduce the activity of IFN-gamma, as has been shown for penicillin G. beta-Lactams 46-57 interferon gamma Homo sapiens 116-125 16239287-1 2005 OBJECTIVES: To investigate whether a range of beta-lactam antibiotics conjugate to and hence reduce the activity of IFN-gamma, as has been shown for penicillin G. Penicillin G 149-161 interferon gamma Homo sapiens 116-125 16239287-4 2005 RESULTS: Clavulanic acid, cefoxitin and cefaloridine were the most potent inhibitors of IFN-gamma activity, followed by cefotaxime, ceftriaxone and phenoxymethylpenicillin. Clavulanic Acid 9-24 interferon gamma Homo sapiens 88-97 16239287-4 2005 RESULTS: Clavulanic acid, cefoxitin and cefaloridine were the most potent inhibitors of IFN-gamma activity, followed by cefotaxime, ceftriaxone and phenoxymethylpenicillin. Cefoxitin 26-35 interferon gamma Homo sapiens 88-97 16239287-4 2005 RESULTS: Clavulanic acid, cefoxitin and cefaloridine were the most potent inhibitors of IFN-gamma activity, followed by cefotaxime, ceftriaxone and phenoxymethylpenicillin. Cephaloridine 40-52 interferon gamma Homo sapiens 88-97 16239287-8 2005 CONCLUSIONS: beta-Lactams differ in their capacity to modulate human IFN-gamma activity. beta-Lactams 13-25 interferon gamma Homo sapiens 69-78 16204617-5 2005 In addition, sulfydryl reagents have a strong inhibitory effect on DNA methylation activity and also induce IFN-gamma gene expression, thus suggesting a link between both effects. sulfydryl reagents 13-31 interferon gamma Homo sapiens 108-117 16375605-3 2005 IFN regulatory factor-4 (IRF-4) and IRF-8 (formerly PU.1 interaction partner [Pip] and IFN consensus sequence binding domain [ICSBP], respectively) are immune cell-specific members of the IRF family that regulate the development of myeloid, lymphoid, and dendritic cells. pip 78-81 interferon gamma Homo sapiens 0-3 16188436-4 2005 When peripheral mononuclear cells from recurrent aborters are incubated with progesterone or dydrogesterone in vitro, T-helper (Th)2 cytokines such as interleukin (IL)-4 and IL-6 markedly increase whereas the Th1 cytokine interferon-gamma decreases. Progesterone 77-89 interferon gamma Homo sapiens 222-238 16447674-5 2005 The data demonstrate that LHXT has the actions of reducing serum levels of TNF-alpha, IFN-gamma and IL-6 in psoriasis of blood-heat type, and may exert a pharmacological effect targeting at the cytokines. lhxt 26-30 interferon gamma Homo sapiens 86-95 16394644-1 2005 Indoleamine 2,3-dioxygenase (IDO), one of the enzymes of tryptophan catabolism, has been shown to play an essential role for successful pregnancy through the inhibition of allogenic fetus-induced T-cell proliferation, and interferon-gamma (IFN-gamma) induces the expression of IDO in CD14-positive (CD14(+)) cells. Tryptophan 57-67 interferon gamma Homo sapiens 222-238 16301659-0 2005 The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-gamma-mediated macrophage killing. exopolysaccharide 4-21 interferon gamma Homo sapiens 85-94 16301659-0 2005 The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-gamma-mediated macrophage killing. Alginates 22-30 interferon gamma Homo sapiens 85-94 16301659-6 2005 Human leukocytes, in the presence of recombinant human IFN-gamma, killed biofilm bacteria lacking alginate after a 4-h challenge at 37 degrees C. Bacterial killing was dependent on the presence of IFN-gamma. Alginates 98-106 interferon gamma Homo sapiens 55-64 16301659-8 2005 By direct microscopic observation, phagocytosis of alginate-negative biofilm bacteria was significantly increased in the presence of IFN-gamma vs all other treatments. Alginates 51-59 interferon gamma Homo sapiens 133-142 16311916-2 2005 The expression of inducible nitric oxide synthase (iNOS) and generation of nitric oxide in response to IFN-gamma and TNF-alpha is important in control of infection. Nitric Oxide 28-40 interferon gamma Homo sapiens 103-112 16394644-1 2005 Indoleamine 2,3-dioxygenase (IDO), one of the enzymes of tryptophan catabolism, has been shown to play an essential role for successful pregnancy through the inhibition of allogenic fetus-induced T-cell proliferation, and interferon-gamma (IFN-gamma) induces the expression of IDO in CD14-positive (CD14(+)) cells. Tryptophan 57-67 interferon gamma Homo sapiens 240-249 16168523-6 2005 Pharmacologic inhibition of NOS2 with (+/-)-2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT) significantly reduced neuronal apoptosis, and the addition of low concentrations of the NO donor, S-nitroso-N-acetylpenicillamine (SNAP), to neurons cultured without astrocytes was sufficient to recover the apoptotic phenotype following exposure to Mn and TNF-alpha/IFN-gamma. 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine 90-93 interferon gamma Homo sapiens 361-370 16235181-3 2005 METHODS: A whole-blood assay was developed that used IFN-gamma secretion in response to BrHPP as a measurement of Vdelta2(+) T cell function. bromohydrin pyrophosphate 88-93 interferon gamma Homo sapiens 53-62 15968631-8 2005 The toxic concentration of IFN-gamma, and TNF-alpha was lower if the cells were iron loaded, but iron loading had no effect on the toxicity of IL-1beta. Iron 80-84 interferon gamma Homo sapiens 27-36 16216004-8 2005 In patients treated with LMWH, the plasma levels of IL-6, IL-10, IFN-gamma, and P-selectin demonstrated similar correlations with survival. Heparin, Low-Molecular-Weight 25-29 interferon gamma Homo sapiens 65-74 16235181-4 2005 RESULTS: Peak IFN-gamma levels were detected after stimulating whole blood with BrHPP for 7-9 days. bromohydrin pyrophosphate 80-85 interferon gamma Homo sapiens 14-23 16235181-7 2005 When 50 micromol/L BrHPP was used, 100% of healthy subjects produced IFN-gamma. bromohydrin pyrophosphate 19-24 interferon gamma Homo sapiens 69-78 16227806-1 2005 We used an A-class CpG oligodeoxynucleotide to explore innate immunity in HIV infection and observed that natural killer cells from progressors showed a markedly lower IFN-gamma production in response to the oligonuclotide as compared with long-term non-progressing subjects and healthy HIV-negative individuals. oligonuclotide 208-222 interferon gamma Homo sapiens 168-177 16272364-6 2005 The results show that HLA-DP Glu69- and HLA-DR Glu71-expressing molecules are capable of inducing beryllium-specific proliferation and IFN-gamma expression by lung CD4+ T cells. Beryllium 98-107 interferon gamma Homo sapiens 135-144 16155294-0 2005 Heparan sulfate mimicry: a synthetic glycoconjugate that recognizes the heparin binding domain of interferon-gamma inhibits the cytokine activity. Heparitin Sulfate 0-15 interferon gamma Homo sapiens 98-114 16155294-0 2005 Heparan sulfate mimicry: a synthetic glycoconjugate that recognizes the heparin binding domain of interferon-gamma inhibits the cytokine activity. Heparin 72-79 interferon gamma Homo sapiens 98-114 16155294-5 2005 Among them, interferon-gamma (IFNgamma), a dimeric cytokine, binds to a complex oligosaccharide motif encompassing a N-acetylated glucosamine-rich domain and two highly sulfated sequences, each of which binds to one IFNgamma monomer. Oligosaccharides 80-95 interferon gamma Homo sapiens 12-28 16155294-5 2005 Among them, interferon-gamma (IFNgamma), a dimeric cytokine, binds to a complex oligosaccharide motif encompassing a N-acetylated glucosamine-rich domain and two highly sulfated sequences, each of which binds to one IFNgamma monomer. Oligosaccharides 80-95 interferon gamma Homo sapiens 30-38 16155294-5 2005 Among them, interferon-gamma (IFNgamma), a dimeric cytokine, binds to a complex oligosaccharide motif encompassing a N-acetylated glucosamine-rich domain and two highly sulfated sequences, each of which binds to one IFNgamma monomer. Oligosaccharides 80-95 interferon gamma Homo sapiens 216-224 16155294-5 2005 Among them, interferon-gamma (IFNgamma), a dimeric cytokine, binds to a complex oligosaccharide motif encompassing a N-acetylated glucosamine-rich domain and two highly sulfated sequences, each of which binds to one IFNgamma monomer. Glucosamine 130-141 interferon gamma Homo sapiens 12-28 16155294-5 2005 Among them, interferon-gamma (IFNgamma), a dimeric cytokine, binds to a complex oligosaccharide motif encompassing a N-acetylated glucosamine-rich domain and two highly sulfated sequences, each of which binds to one IFNgamma monomer. Glucosamine 130-141 interferon gamma Homo sapiens 30-38 16155294-7 2005 One of these molecules, composed of two authentic N-sulfated octasaccharides linked to each other through a 50-Angstroms-long spacer termed 2O(10), displays high affinity for the cytokine and inhibits IFNgamma-HS binding with an IC(50) of 35-40 nm. n-sulfated octasaccharides 50-76 interferon gamma Homo sapiens 201-209 16174516-4 2005 Inhibition of NHE1 activity by IFN-gamma was absent after pretreatment with cariporide. cariporide 76-86 interferon gamma Homo sapiens 31-40 16254053-10 2005 Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II. Arginine 67-75 interferon gamma Homo sapiens 149-158 16254053-10 2005 Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II. Arginine 105-113 interferon gamma Homo sapiens 149-158 16356125-3 2005 Of these constituents, aframodial (20 microM) exhibited marked suppressive effects on 12-O-tetradecanoylphorbol-13-acetate-induced O(2) () generation in HL-60 cells and lipopolysaccharide (LPS)/interferon-gamma-induced nitric oxide (NO) generation in RAW264.7 cells (inhibition rates [IRs]=84.6% and 95.9%, respectively). 8,17-epoxylabd-12-ene-15,16-dial 23-33 interferon gamma Homo sapiens 194-210 16174516-6 2005 Inhibition of signal transducer and activator transcription factor 1 (STAT1) with epigallocatechin-3-gallate (EGCG) prevented the inhibitory effect of IFN-gamma. epigallocatechin gallate 110-114 interferon gamma Homo sapiens 151-160 16174516-7 2005 Treatment with IFN-gamma activated phospho-STAT1 was markedly attenuated by EGCG. epigallocatechin gallate 76-80 interferon gamma Homo sapiens 15-24 16174516-8 2005 The IFN-gamma-induced increase in surface NHE1 and ERM abundance was prevented by EGCG. epigallocatechin gallate 82-86 interferon gamma Homo sapiens 4-13 16174516-6 2005 Inhibition of signal transducer and activator transcription factor 1 (STAT1) with epigallocatechin-3-gallate (EGCG) prevented the inhibitory effect of IFN-gamma. epigallocatechin gallate 82-108 interferon gamma Homo sapiens 151-160 16136269-0 2005 Conversion of Fas-resistant to Fas-sensitive MCF-7 breast cancer cells by the synergistic interaction of interferon-gamma and all-trans retinoic acid. ammonium ferrous sulfate 14-17 interferon gamma Homo sapiens 105-121 16136269-0 2005 Conversion of Fas-resistant to Fas-sensitive MCF-7 breast cancer cells by the synergistic interaction of interferon-gamma and all-trans retinoic acid. ammonium ferrous sulfate 31-34 interferon gamma Homo sapiens 105-121 16275946-6 2005 Using our selected peptides, IFN-gamma production, evaluated by both WBE and ELISPOT, was significantly higher in patients with A-TB than in controls (P < 0.0001). Terbium 130-132 interferon gamma Homo sapiens 29-38 16186161-1 2005 Using intracellular cytokine staining we show herein that T cells will respond to short-term (6 h) activation with phorbol ester plus ionomycin by production of tumor necrosis factor (TNF), IFN-gamma or both. Phorbol Esters 115-128 interferon gamma Homo sapiens 190-199 16125466-3 2005 The proportion of CD4+ and CD8+ T cells that produced IFN-gamma and IL-4 after stimulation with PMA (Phorbol 12-myristate 13-acetate) and ionomycin was significantly reduced in VL patients compared to sub-clinical and asymptomatic infections or healthy controls. Tetradecanoylphorbol Acetate 96-99 interferon gamma Homo sapiens 54-63 16125466-3 2005 The proportion of CD4+ and CD8+ T cells that produced IFN-gamma and IL-4 after stimulation with PMA (Phorbol 12-myristate 13-acetate) and ionomycin was significantly reduced in VL patients compared to sub-clinical and asymptomatic infections or healthy controls. Tetradecanoylphorbol Acetate 101-132 interferon gamma Homo sapiens 54-63 16125466-3 2005 The proportion of CD4+ and CD8+ T cells that produced IFN-gamma and IL-4 after stimulation with PMA (Phorbol 12-myristate 13-acetate) and ionomycin was significantly reduced in VL patients compared to sub-clinical and asymptomatic infections or healthy controls. Ionomycin 138-147 interferon gamma Homo sapiens 54-63 16250037-8 2005 Lamivudine plus rhIL-12 treatment was associated with a greater increase in virus-specific T-cell reactivity, IFN-gamma production, and an inverse correlation between the frequency of IFN-gamma-producing CD4+ T-cells and viremia. Lamivudine 0-10 interferon gamma Homo sapiens 110-119 16250037-8 2005 Lamivudine plus rhIL-12 treatment was associated with a greater increase in virus-specific T-cell reactivity, IFN-gamma production, and an inverse correlation between the frequency of IFN-gamma-producing CD4+ T-cells and viremia. Lamivudine 0-10 interferon gamma Homo sapiens 184-193 16250037-10 2005 In conclusion, the addition of IL-12 to lamivudine enhances T-cell reactivity to HBV and IFN-gamma production. Lamivudine 40-50 interferon gamma Homo sapiens 89-98 16091294-3 2005 Sodium butyrate significantly repressed the phosphorylation of ERK induced by IFN-gamma, but had little effect on that induced by LPS. Butyric Acid 0-15 interferon gamma Homo sapiens 78-87 16237110-10 2005 Furthermore, cytolytic functions of PMA and ionomycin-stimulated CD8brightCD56+ T cells against HUVECs were greatly enhanced, by pretreatment of recombinant human IFN-gamma on HUVECs. Ionomycin 44-53 interferon gamma Homo sapiens 163-172 16091294-0 2005 Repression of interferon-gamma-induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways. Butyric Acid 110-125 interferon gamma Homo sapiens 14-30 16091294-4 2005 This suggests that sodium butyrate suppresses the IFN-gamma-induced iNOS expression by inhibiting the ERK to NF-kappaB pathway. Butyric Acid 19-34 interferon gamma Homo sapiens 50-59 16091294-1 2005 We have reported recently that sodium butyrate suppressed IFN-gamma, but not the LPS-mediated induction of nitric oxide and TNF-alpha in microglia via the specific inhibition of NF-kappaB. Butyric Acid 31-46 interferon gamma Homo sapiens 58-67 16091294-2 2005 In order to further determine the upstream signaling mechanism involved in the IFN-gamma-specific down-regulation of iNOS by sodium butyrate in microglia, this study investigated the effect of sodium butyrate on the MAP kinase activities. Butyric Acid 125-140 interferon gamma Homo sapiens 79-88 16091294-5 2005 In addition, it was found that sodium butyrate suppressed the IFN-gamma-induced interferon regulatory factor 1 (IRF-1) expression via the inhibition of ERK. Butyric Acid 31-46 interferon gamma Homo sapiens 62-71 16091294-2 2005 In order to further determine the upstream signaling mechanism involved in the IFN-gamma-specific down-regulation of iNOS by sodium butyrate in microglia, this study investigated the effect of sodium butyrate on the MAP kinase activities. Butyric Acid 193-208 interferon gamma Homo sapiens 79-88 16091294-6 2005 Therefore, the ERK signaling pathway appears to play a key role in the sodium butyrate-mediated down-regulation of iNOS in the IFN-gamma-stimulated microglia. Butyric Acid 71-86 interferon gamma Homo sapiens 127-136 16238585-9 2005 Dexamethasone decreased AHR and markedly reduced the recruitment of inflammatory cells and production of IFN-gamma. Dexamethasone 0-13 interferon gamma Homo sapiens 105-114 16371322-9 2005 PD98059, an inhibitor of MAP kinase (MEK), reduced the IFN-gamma-induced NO production by 40%. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 interferon gamma Homo sapiens 55-64 16085646-9 2005 In addition, atRA pretreatment affected the transcriptional functions of IFNgamma-induced IRF-1, increasing its nuclear localization and DNA binding activity as well as the transcript levels of IRF-1 target genes. Tretinoin 13-17 interferon gamma Homo sapiens 73-81 16175582-0 2005 Differential effects of ethanol on glial signal transduction initiated by lipopolysaccharide and interferon-gamma. Ethanol 24-31 interferon gamma Homo sapiens 97-113 16085646-0 2005 Physiological and receptor-selective retinoids modulate interferon gamma signaling by increasing the expression, nuclear localization, and functional activity of interferon regulatory factor-1. Retinoids 37-46 interferon gamma Homo sapiens 56-72 16085646-3 2005 In this study, we have used the human lung epithelial cell line A549 to examine the effect of atRA on IFNgamma-induced expression of IFN regulatory factor-1 (IRF-1), an important transcription factor involved in cell growth and apoptosis, differentiation, and antiviral and antibacterial immune responses. Tretinoin 94-98 interferon gamma Homo sapiens 102-110 16085646-4 2005 At least 4 h of pretreatment with atRA followed by suboptimal concentrations of IFNgamma induced a faster, higher, and more stable expression of IRF-1 than IFNgamma alone. Tretinoin 34-38 interferon gamma Homo sapiens 156-164 16210632-7 2005 In response to IFN-gamma, phosphorylation of two tyrosine residues in the HoxA10 homeodomain decreases binding to CYBB promoter, thereby abrogating HoxA10-mediated repression. Tyrosine 49-57 interferon gamma Homo sapiens 15-24 16186183-5 2005 Early graft loss was successfully prevented through the repeated administration of alpha-galactosylceramide, a specific ligand for Valpha14 NKT cells, resulting in dramatically reduced IFN-gamma production by Gr-1+CD11b+ cells, as well as Valpha14 NKT cells. alpha-galactosylceramide 83-107 interferon gamma Homo sapiens 185-194 16135013-5 2005 RESULTS: EBs had higher ratios of interferon-gamma (IFN-gamma)/interleukin-10 (IL-10) than EFs, and post-partums were higher than Cs. ethylbenzene 9-12 interferon gamma Homo sapiens 34-50 16135013-5 2005 RESULTS: EBs had higher ratios of interferon-gamma (IFN-gamma)/interleukin-10 (IL-10) than EFs, and post-partums were higher than Cs. ethylbenzene 9-12 interferon gamma Homo sapiens 52-61 16107341-5 2005 Moreover, Stat1-CC still required ligand-dependent Tyr-701 phosphorylation for function and exhibited hyperresponsiveness to IFN-beta (that depends on Stat1/Stat2 heterodimerization) as well as IFN-gamma (that depends on Stat1/Stat1 homodimerization). Tyrosine 51-54 interferon gamma Homo sapiens 194-203 15908056-5 2005 RESULTS: IFN-gamma concentration was significantly lower in cultures containing 10(-4) M kaempferol than in cultures with kaempferol at 10(-7), 10(-6)and 10(-5) M or without kaempferol. kaempferol 89-99 interferon gamma Homo sapiens 9-18 15908056-5 2005 RESULTS: IFN-gamma concentration was significantly lower in cultures containing 10(-4) M kaempferol than in cultures with kaempferol at 10(-7), 10(-6)and 10(-5) M or without kaempferol. kaempferol 122-132 interferon gamma Homo sapiens 9-18 15908056-5 2005 RESULTS: IFN-gamma concentration was significantly lower in cultures containing 10(-4) M kaempferol than in cultures with kaempferol at 10(-7), 10(-6)and 10(-5) M or without kaempferol. kaempferol 122-132 interferon gamma Homo sapiens 9-18 16202375-0 2005 When, and when not, to use the interferon-gamma TB test. Terbium 48-50 interferon gamma Homo sapiens 31-47 16051523-4 2005 Atorvastatin did not affect IL-1beta, but suppressed IL-1ra, IL-2 and IFNgamma production. Atorvastatin 0-12 interferon gamma Homo sapiens 70-78 16084984-1 2005 OBJECTIVES: Neopterin is produced by human monocyte-derived macrophages upon stimulation with interferon-gamma and is therefore a sensitive indicator for cellular immune activation. Neopterin 12-21 interferon gamma Homo sapiens 94-110 16181324-4 2005 Interferon-gamma (IFN-gamma) helps to override these limitations by the formation of immunoproteasomes, the activator complex PA28, and the induction of several aminopeptidases. pa28 126-130 interferon gamma Homo sapiens 0-16 16181324-4 2005 Interferon-gamma (IFN-gamma) helps to override these limitations by the formation of immunoproteasomes, the activator complex PA28, and the induction of several aminopeptidases. pa28 126-130 interferon gamma Homo sapiens 18-27 15922476-1 2005 BACKGROUND/AIMS: The functions of mouse liver NK1.1+ T (NKT) cells stimulated with alpha-galactosylceramide (alpha-GalCer) are enhanced age dependently, and the antitumor and anti-metastatic effect in the liver is dependent on IFN-gamma. alpha-galactosylceramide 83-107 interferon gamma Homo sapiens 227-236 15922476-1 2005 BACKGROUND/AIMS: The functions of mouse liver NK1.1+ T (NKT) cells stimulated with alpha-galactosylceramide (alpha-GalCer) are enhanced age dependently, and the antitumor and anti-metastatic effect in the liver is dependent on IFN-gamma. alpha-galactosylceramide 109-121 interferon gamma Homo sapiens 227-236 16081597-0 2005 Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production. th2 96-99 interferon gamma Homo sapiens 143-153 16157237-13 2005 RNA and deoxyadenosine monophosphate cocultured with virus antigen significantly increased peripheral blood mononuclear cell secretion of IFN-gamma, interleukin-10, and tumor necrosis factor-alpha. 2'-deoxy-5'-adenosine monophosphate 8-36 interferon gamma Homo sapiens 138-147 16895688-7 2005 Furthermore, fluvastatin potentiates the MHC class I upregulation but prevents MHC class II induction triggered by IFNgamma. Fluvastatin 13-24 interferon gamma Homo sapiens 115-123 16157237-15 2005 Deoxyguanosine monophosphate completely inhibited virus-triggered IFN-gamma secretion, whereas thymosine monophosphate did not change the secretion pattern of measured cytokines. 2'-deoxyguanosine 5'-phosphate 0-28 interferon gamma Homo sapiens 66-75 15985639-7 2005 Dex alone increased the expression of only 22 genes and inhibited the expression of 7 genes compared with controls at 24 h. The effect of Dex on IFN-gamma-induced changes suggests a specific, targeted effect on IFN-gamma responses that is substantially greater than the effect of Dex alone. Dexamethasone 0-3 interferon gamma Homo sapiens 145-154 16084608-2 2005 Interferon-gamma released from T-cells results in macrophage synthesis of 7,8-dihydroneopterin which has antioxidant and cytoprotective activity. 7,8-dihydroneopterin 74-94 interferon gamma Homo sapiens 0-16 15985639-0 2005 Influence of IFN-gamma on gene expression in normal human bronchial epithelial cells: modulation of IFN-gamma effects by dexamethasone. Dexamethasone 121-134 interferon gamma Homo sapiens 100-109 15985639-7 2005 Dex alone increased the expression of only 22 genes and inhibited the expression of 7 genes compared with controls at 24 h. The effect of Dex on IFN-gamma-induced changes suggests a specific, targeted effect on IFN-gamma responses that is substantially greater than the effect of Dex alone. Dexamethasone 0-3 interferon gamma Homo sapiens 211-220 15985639-5 2005 With a 5% false discovery rate, of the 66 genes upregulated by IFN-gamma by twofold or greater at 8 h and 287 genes upregulated at 24 h, coincubation with Dex inhibited the expression of 2 genes at 8 h and 45 genes at 24 h. Prominent among these were cytokines and secreted proteins. Dexamethasone 155-158 interferon gamma Homo sapiens 63-72 15985639-6 2005 Dex cotreatment increased expression of 65 of the 376 genes that were inhibited by IFN-gamma by 50% at 24 h. The majority of these genes encode cell cycle or nuclear proteins. Dexamethasone 0-3 interferon gamma Homo sapiens 83-92 15985639-7 2005 Dex alone increased the expression of only 22 genes and inhibited the expression of 7 genes compared with controls at 24 h. The effect of Dex on IFN-gamma-induced changes suggests a specific, targeted effect on IFN-gamma responses that is substantially greater than the effect of Dex alone. Dexamethasone 138-141 interferon gamma Homo sapiens 145-154 15985639-7 2005 Dex alone increased the expression of only 22 genes and inhibited the expression of 7 genes compared with controls at 24 h. The effect of Dex on IFN-gamma-induced changes suggests a specific, targeted effect on IFN-gamma responses that is substantially greater than the effect of Dex alone. Dexamethasone 138-141 interferon gamma Homo sapiens 145-154 16076437-3 2005 Next a monoclonal anti-IFN-gamma antibody, MD-2, was covalently attached to dextran-modified mercaptoundecanoic acid surfaces that performed best. Dextrans 76-83 interferon gamma Homo sapiens 23-32 16076437-3 2005 Next a monoclonal anti-IFN-gamma antibody, MD-2, was covalently attached to dextran-modified mercaptoundecanoic acid surfaces that performed best. mercaptoundecanoic acid 93-116 interferon gamma Homo sapiens 23-32 16076437-4 2005 On coatings consisting of carboxyl-modified dextran (CMD) a difference in interaction behaviour was observed when IFN-gamma was injected in either buffer or diluted plasma. carboxyl-modified dextran 26-51 interferon gamma Homo sapiens 114-123 16076437-11 2005 From the coatings tested, the non-modified dextran-coated SPR sensor disks prove to be best suited for the detection of IFN-gamma in complex matrices like plasma. Dextrans 43-50 interferon gamma Homo sapiens 120-129 16141532-7 2005 Interestingly, A23187 synergized with the activities of CKBM-treated THP-1 cells in terms of IL-1beta and IFNgamma production, while the IL-10 production showed no synergistic relationship between CKBM and A23187. Calcimycin 15-21 interferon gamma Homo sapiens 106-114 16154495-0 2005 Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitro. Resveratrol 0-11 interferon gamma Homo sapiens 23-39 16154495-4 2005 In this in vitro study, the modulatory effect of resveratrol on two interferon-gamma-mediated pathways, the degradation of tryptophan by the enzyme indoleamine 2,3-dioxygenase, and the production of neopterin by activation of the GTP-cyclohydrolase I, was tested. Resveratrol 49-60 interferon gamma Homo sapiens 68-84 16154495-6 2005 A significant down-regulatory effect of resveratrol on both biochemical pathways was found, and also the production of Th1-type cytokine interferon-gamma was significantly suppressed. Resveratrol 40-51 interferon gamma Homo sapiens 137-153 16007204-6 2005 Interestingly, while the upregulation of STAT-1 by IFNgamma is partially inhibited by RA, IFNgamma is shown to repress RA-driven TGFbeta-2 induction, pointing to the involvement of alternative mechanism(s) in IFNgamma-RA synergism. Tretinoin 86-88 interferon gamma Homo sapiens 51-59 15994321-8 2005 Although LPL alone had no effect on Stat1 activation, LPL enhanced IFN-gamma-induced phosphorylation of Stat1 on tyrosine 701 and serine 727, as well as Stat1-mediated transactivation. Tyrosine 113-121 interferon gamma Homo sapiens 67-76 15994321-8 2005 Although LPL alone had no effect on Stat1 activation, LPL enhanced IFN-gamma-induced phosphorylation of Stat1 on tyrosine 701 and serine 727, as well as Stat1-mediated transactivation. Serine 130-136 interferon gamma Homo sapiens 67-76 15994321-9 2005 The synergistic effect of LPL on IFN-gamma-induced Stat1 activation was mediated by enhanced activation of the tyrosine kinase JAK2 and was abrogated by LY294002, a specific inhibitor of the phosphatidylinositol 3"-kinase pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 153-161 interferon gamma Homo sapiens 33-42 16129704-2 2005 We report here that nitric oxide (NO) generated by IFNgamma-activated macrophages abrogates the intracellular survival advantage associated with a functional SPI2 type III secretion system. Nitric Oxide 20-32 interferon gamma Homo sapiens 51-59 16115026-6 2005 In cells preincubated with D609, IFNgamma-mediated PKC alpha depletion was attenuated, whereas U73122 did not impair this process. tricyclodecane-9-yl-xanthogenate 27-31 interferon gamma Homo sapiens 33-41 16115026-7 2005 Moreover, phorbol 12-myristate 13-acetate-initiated ROS formation, which was attenuated in macrophages pretreated with IFNgamma, was restored in the presence of the PC-PLC inhibitor. Tetradecanoylphorbol Acetate 10-41 interferon gamma Homo sapiens 119-127 16115026-7 2005 Moreover, phorbol 12-myristate 13-acetate-initiated ROS formation, which was attenuated in macrophages pretreated with IFNgamma, was restored in the presence of the PC-PLC inhibitor. Reactive Oxygen Species 52-55 interferon gamma Homo sapiens 119-127 16115026-8 2005 These results suggest that IFNgamma causes PC-PLC stimulation, diacylglycerol release, Ca2+ influx, and concomitant PKC alpha activation, which subsequently depletes PKC alpha. Diglycerides 63-77 interferon gamma Homo sapiens 27-35 16141532-7 2005 Interestingly, A23187 synergized with the activities of CKBM-treated THP-1 cells in terms of IL-1beta and IFNgamma production, while the IL-10 production showed no synergistic relationship between CKBM and A23187. ckbm 56-60 interferon gamma Homo sapiens 106-114 16140960-4 2005 We observed that the myeloma cell lines MM1.S, RPMI8226, and U266 contain active immunoproteasomes, the amount of which is enhanced by IFN-gamma and tumor necrosis factor-alpha. rpmi8226 47-55 interferon gamma Homo sapiens 135-176 15936988-2 2005 Simvastatin, an HMG-CoA reductase inhibitor with mild inhibition of LFA-1, induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma in human peripheral blood mononuclear cells (PBMC). Simvastatin 0-11 interferon gamma Homo sapiens 160-182 16213476-9 2005 Culture supernatant from PBMC stimulated in the presence of EGCG failed to increase the permeability of T84 epithelial cell monolayers: a finding consistent with the reduced IFNgamma and TNFalpha production by SAg+EGCG treated PBMC. epigallocatechin gallate 60-64 interferon gamma Homo sapiens 174-182 15936988-5 2005 In the presence of IL-18, simvastatin suppressed the expression of ICAM-1 and CD40 as well as the production of IL-12, TNF-alpha and IFN-gamma in PBMC, contributing to the anti-inflammatory effect of simvastatin. Simvastatin 26-37 interferon gamma Homo sapiens 133-142 16045733-5 2005 As a result of it the amount of interferon-gamma producing CD7(+) T-cells and the concentration of interferon-gamma in cultural supernatants were maximal in the cell cultures incubated with anti-CD3, interleukin-7 and dexamethasone during the first 68 h and subsequently restimulated with phorbol 12-myristate 13-acetate and ionomycin. Ionomycin 325-334 interferon gamma Homo sapiens 99-115 15936988-5 2005 In the presence of IL-18, simvastatin suppressed the expression of ICAM-1 and CD40 as well as the production of IL-12, TNF-alpha and IFN-gamma in PBMC, contributing to the anti-inflammatory effect of simvastatin. Simvastatin 200-211 interferon gamma Homo sapiens 133-142 16045733-0 2005 Ex vivo stimulation of cord blood mononuclear cells by dexamethasone and interleukin-7 results in the maturation of interferon-gamma-secreting effector memory T cells. Dexamethasone 55-68 interferon gamma Homo sapiens 116-132 16045733-3 2005 Dexamethasone suppressed production of interferon-gamma in 68-h cell cultures stimulated with anti-CD3 both in the presence of interleukin-7 and without it. Dexamethasone 0-13 interferon gamma Homo sapiens 39-55 16045733-4 2005 However, a 68-h cultivation of newborn blood cells with dexamethasone, anti-CD3 and interleukin-7 resulted in the accumulation of T-lymphocytes capable of producing interferon-gamma after restimulation. Dexamethasone 56-69 interferon gamma Homo sapiens 165-181 16045733-5 2005 As a result of it the amount of interferon-gamma producing CD7(+) T-cells and the concentration of interferon-gamma in cultural supernatants were maximal in the cell cultures incubated with anti-CD3, interleukin-7 and dexamethasone during the first 68 h and subsequently restimulated with phorbol 12-myristate 13-acetate and ionomycin. Dexamethasone 218-231 interferon gamma Homo sapiens 32-48 16045733-5 2005 As a result of it the amount of interferon-gamma producing CD7(+) T-cells and the concentration of interferon-gamma in cultural supernatants were maximal in the cell cultures incubated with anti-CD3, interleukin-7 and dexamethasone during the first 68 h and subsequently restimulated with phorbol 12-myristate 13-acetate and ionomycin. Dexamethasone 218-231 interferon gamma Homo sapiens 99-115 16045733-5 2005 As a result of it the amount of interferon-gamma producing CD7(+) T-cells and the concentration of interferon-gamma in cultural supernatants were maximal in the cell cultures incubated with anti-CD3, interleukin-7 and dexamethasone during the first 68 h and subsequently restimulated with phorbol 12-myristate 13-acetate and ionomycin. Tetradecanoylphorbol Acetate 289-320 interferon gamma Homo sapiens 32-48 16045733-5 2005 As a result of it the amount of interferon-gamma producing CD7(+) T-cells and the concentration of interferon-gamma in cultural supernatants were maximal in the cell cultures incubated with anti-CD3, interleukin-7 and dexamethasone during the first 68 h and subsequently restimulated with phorbol 12-myristate 13-acetate and ionomycin. Tetradecanoylphorbol Acetate 289-320 interferon gamma Homo sapiens 99-115 16045733-5 2005 As a result of it the amount of interferon-gamma producing CD7(+) T-cells and the concentration of interferon-gamma in cultural supernatants were maximal in the cell cultures incubated with anti-CD3, interleukin-7 and dexamethasone during the first 68 h and subsequently restimulated with phorbol 12-myristate 13-acetate and ionomycin. Ionomycin 325-334 interferon gamma Homo sapiens 32-48 16078278-7 2005 Further analysis shows that, depending on the cytokine pattern of NK cell activation, phosphorylcholine-containing lipids differentially affect IFN-gamma secretion by these cells. Phosphorylcholine 86-103 interferon gamma Homo sapiens 144-153 16006447-1 2005 OBJECTIVES: To test whether ciprofloxacin, moxifloxacin and clarithromycin affect the expression of the T helper (Th) cell cytokines, interferon-gamma and interleukin-4. Ciprofloxacin 28-41 interferon gamma Homo sapiens 134-150 16006447-8 2005 RESULTS: Both moxifloxacin and ciprofloxacin dose-dependently decreased interferon-gamma and interleukin-4 expression by Th cells (both P<0.0001). Moxifloxacin 14-26 interferon gamma Homo sapiens 72-88 16006447-8 2005 RESULTS: Both moxifloxacin and ciprofloxacin dose-dependently decreased interferon-gamma and interleukin-4 expression by Th cells (both P<0.0001). Ciprofloxacin 31-44 interferon gamma Homo sapiens 72-88 16006447-1 2005 OBJECTIVES: To test whether ciprofloxacin, moxifloxacin and clarithromycin affect the expression of the T helper (Th) cell cytokines, interferon-gamma and interleukin-4. Clarithromycin 60-74 interferon gamma Homo sapiens 134-150 16116176-7 2005 However, pretreatment with intracellular calcium chelator BAPTA-AM or disruption of lipid rafts using methyl beta-cyclodextrin completely abrogated IFN-gamma-induced Hsp72 release. Calcium 41-48 interferon gamma Homo sapiens 148-157 16116176-7 2005 However, pretreatment with intracellular calcium chelator BAPTA-AM or disruption of lipid rafts using methyl beta-cyclodextrin completely abrogated IFN-gamma-induced Hsp72 release. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 58-66 interferon gamma Homo sapiens 148-157 16116176-7 2005 However, pretreatment with intracellular calcium chelator BAPTA-AM or disruption of lipid rafts using methyl beta-cyclodextrin completely abrogated IFN-gamma-induced Hsp72 release. methyl-beta-cyclodextrin 102-126 interferon gamma Homo sapiens 148-157 16116186-3 2005 Stimulation with the GiPCR ligands C5a and 1-deoxy-1-[6-[(3-iodophenyl)methyl]amino]-9H-purine-9-y1]-N-methyl-beta-D-ribofuranuronamide (IB-MECA) blocked the production of IL-12 p70 by human monocytes stimulated with LPS and IFN-gamma. 1-deoxy-1-[6-[(3-iodophenyl)methyl]amino]-9h-purine-9-y1]-n-methyl-beta-d-ribofuranuronamide 43-135 interferon gamma Homo sapiens 225-234 16117790-2 2005 Inhibitors for nuclear factor kappa B (NFkappaB), parthenolide, and Bay 11-7085, and an inhibitor of p38, SB202190, inhibited TNFalpha- and IFNgamma-induced production of CCL17 by HaCaT KC. BAY 11-7085 68-79 interferon gamma Homo sapiens 140-148 16117790-2 2005 Inhibitors for nuclear factor kappa B (NFkappaB), parthenolide, and Bay 11-7085, and an inhibitor of p38, SB202190, inhibited TNFalpha- and IFNgamma-induced production of CCL17 by HaCaT KC. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 106-114 interferon gamma Homo sapiens 140-148 16117790-4 2005 Roxithromycin (RXM), a 14-membered ring macrolide, suppressed CCL17 production by HaCaT KC induced by IFNgamma and TNFalpha. Roxithromycin 0-13 interferon gamma Homo sapiens 102-110 16181054-4 2005 The addition of IFN-gamma, alone or in combination with TNF-alpha, increased spontaneous superoxide release by PBM and THP-1 cells (p < 0.05) and increased phorbol myristate acetate (PMA)-stimulated superoxide release by CM, PBM, and THP-1 cells (p < 0.05). Superoxides 89-99 interferon gamma Homo sapiens 16-25 16181054-4 2005 The addition of IFN-gamma, alone or in combination with TNF-alpha, increased spontaneous superoxide release by PBM and THP-1 cells (p < 0.05) and increased phorbol myristate acetate (PMA)-stimulated superoxide release by CM, PBM, and THP-1 cells (p < 0.05). pbm 111-114 interferon gamma Homo sapiens 16-25 16181054-4 2005 The addition of IFN-gamma, alone or in combination with TNF-alpha, increased spontaneous superoxide release by PBM and THP-1 cells (p < 0.05) and increased phorbol myristate acetate (PMA)-stimulated superoxide release by CM, PBM, and THP-1 cells (p < 0.05). Tetradecanoylphorbol Acetate 159-184 interferon gamma Homo sapiens 16-25 16181054-4 2005 The addition of IFN-gamma, alone or in combination with TNF-alpha, increased spontaneous superoxide release by PBM and THP-1 cells (p < 0.05) and increased phorbol myristate acetate (PMA)-stimulated superoxide release by CM, PBM, and THP-1 cells (p < 0.05). Tetradecanoylphorbol Acetate 186-189 interferon gamma Homo sapiens 16-25 16181054-4 2005 The addition of IFN-gamma, alone or in combination with TNF-alpha, increased spontaneous superoxide release by PBM and THP-1 cells (p < 0.05) and increased phorbol myristate acetate (PMA)-stimulated superoxide release by CM, PBM, and THP-1 cells (p < 0.05). Superoxides 202-212 interferon gamma Homo sapiens 16-25 16181054-4 2005 The addition of IFN-gamma, alone or in combination with TNF-alpha, increased spontaneous superoxide release by PBM and THP-1 cells (p < 0.05) and increased phorbol myristate acetate (PMA)-stimulated superoxide release by CM, PBM, and THP-1 cells (p < 0.05). pbm 228-231 interferon gamma Homo sapiens 16-25 16049516-6 2005 Furthermore, we show that this apoptosis could be related to the conversion of tryptophan into kynurenine by indoleamine 2,3-dioxygenase expressed by MSC in the presence of IFNgamma. Tryptophan 79-89 interferon gamma Homo sapiens 173-181 16160912-0 2005 The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion. zafirlukast 24-35 interferon gamma Homo sapiens 85-94 16160912-0 2005 The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion. Budesonide 61-71 interferon gamma Homo sapiens 85-94 16049516-6 2005 Furthermore, we show that this apoptosis could be related to the conversion of tryptophan into kynurenine by indoleamine 2,3-dioxygenase expressed by MSC in the presence of IFNgamma. Kynurenine 95-105 interferon gamma Homo sapiens 173-181 16179019-6 2005 When cocultured in vitro with SFMC, CD4+CD25+ T cells purified from either PB or SF were found to exert a considerable suppressive effect on the production of cytokines including TNF-alpha, IFN-gamma and interleukin-10 (IL-10). sfmc 30-34 interferon gamma Homo sapiens 190-199 16135684-0 2005 Local IFN-{gamma} responses in TB. Terbium 31-33 interferon gamma Homo sapiens 6-16 16101728-4 2005 Our results show that high levels of IFN-gamma in pretransplant mixed lymphocyte culture are a highly significant predictor of poorer creatinine levels at 18, 24 and 36 months post-transplant. Creatinine 134-144 interferon gamma Homo sapiens 37-46 16191354-8 2005 Doxycycline and dexamethasone inhibited the IFN-gamma induced increase of express of CD54 and IL-1beta of cultured conjunctival epithelial cells, and the inhibiting effect was dependent on the concentration of doxycycline (P < 0.01). Doxycycline 0-11 interferon gamma Homo sapiens 44-53 16191354-8 2005 Doxycycline and dexamethasone inhibited the IFN-gamma induced increase of express of CD54 and IL-1beta of cultured conjunctival epithelial cells, and the inhibiting effect was dependent on the concentration of doxycycline (P < 0.01). Dexamethasone 16-29 interferon gamma Homo sapiens 44-53 16191354-8 2005 Doxycycline and dexamethasone inhibited the IFN-gamma induced increase of express of CD54 and IL-1beta of cultured conjunctival epithelial cells, and the inhibiting effect was dependent on the concentration of doxycycline (P < 0.01). Doxycycline 210-221 interferon gamma Homo sapiens 44-53 15996247-8 2005 Pre-transplant donor-directed IFN-gamma ELISPOT assessment of anti-donor cellular immunity may function as a "cellular crossmatch" and independently correlates with renal allograft function in African Americans receiving tacrolimus- and sirolimus-based immunosuppression. Tacrolimus 221-231 interferon gamma Homo sapiens 30-39 16103105-5 2005 MICA expressed by myeloma cell lines contributed to killing and IFN-gamma production by Vgamma9/Vdelta2 cells only upon pamidronate treatment, suggesting a dual interaction between Vgamma9/Vdelta2 lymphocytes and multiple myeloma plasma cells involving both TCR triggering and NKG2D-mediated signals. Pamidronate 120-131 interferon gamma Homo sapiens 64-73 16081844-5 2005 The ratio of TNF-alpha- to IFN-gamma-producing CD4+ T cells was higher after stimulation with Ags from heterologous DEN serotypes. Silver 94-97 interferon gamma Homo sapiens 27-36 15996247-8 2005 Pre-transplant donor-directed IFN-gamma ELISPOT assessment of anti-donor cellular immunity may function as a "cellular crossmatch" and independently correlates with renal allograft function in African Americans receiving tacrolimus- and sirolimus-based immunosuppression. Sirolimus 237-246 interferon gamma Homo sapiens 30-39 16051377-0 2005 Polymorphisms in the interferon-gamma gene at position +874 in patients with chronic hepatitis C treated with high-dose interferon-alpha and ribavirin. Ribavirin 141-150 interferon gamma Homo sapiens 21-37 16051377-1 2005 To investigate the influence of the T-to-A polymorphic sequence at position +874 in the interferon (IFN)-gamma gene (+874 IFN-gamma) on the response to combination therapy with high-dose interferon and ribavirin, the single nucleotide polymorphisms were determined by using a polymerase chain reaction sequence-specific primers approach in 150 histologically proved chronic hepatitis C (CHC) patients. Ribavirin 202-211 interferon gamma Homo sapiens 122-131 16061879-4 2005 Compared with peptide-pulsed noninfected APCs or peptide-pulsed APCs infected with wild-type vector, peptide-pulsed APCs infected with rF-TRICOM induced not only more CTLs but also higher-avidity CTLs; this was shown by tetramer staining, tetramer dissociation, IFN-gamma production, and cytolytic assays. rf-tricom 135-144 interferon gamma Homo sapiens 262-271 15969687-11 2005 CONCLUSIONS: These data suggest that IL-4, IL-13 and IFN-gamma play an important roles in penicillins allergy. Penicillins 90-101 interferon gamma Homo sapiens 53-62 16045524-9 2005 RESULTS: Dydrogesterone significantly inhibited the production of the Th1 cytokines IFN-gamma (P= 0.0001) and TNF-alpha (P= 0.005) and induced an increase in the levels of the Th2 cytokines IL-4 (P= 0.03) and IL-6 (P= 0.017) resulting in a substantial shift in the ratio of Th1/Th2 cytokines. Dydrogesterone 9-23 interferon gamma Homo sapiens 84-93 16045524-12 2005 CONCLUSION: Dydrogesterone inhibits the production of the Th1 cytokines IFN-gamma and TNF-alpha from lymphocytes and up-regulates the production of the Th2 cytokines IL-4 and IL-6, inducing a Th1 to Th2 cytokine shift. Dydrogesterone 12-26 interferon gamma Homo sapiens 72-81 16083346-1 2005 Indoleamine 2,3-dioxygenase (IDO) is an interferon (IFN)-gamma-inducible, extrahepatic enzyme that catalyses the initial and rate-limiting step in the degradation of the essential amino acid tryptophan. essential amino acid tryptophan 170-201 interferon gamma Homo sapiens 40-62 15894170-4 2005 LPS/IFN-gamma-induced COX-2 expression in mesangial cells could be inhibited by iNOS inhibitor, aminoguanidine. pimagedine 96-110 interferon gamma Homo sapiens 4-13 15894170-6 2005 Both NO donor and LPS/IFN-gamma markedly activated the PI3K activity and the phosphorylation of Akt and nuclear factor (NF)-kappaB DNA binding activity in mesangial cells, which could be inhibited by LY294002 and transfection of dominant-negative vectors of PI3K/p85 and Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 200-208 interferon gamma Homo sapiens 22-31 15953571-7 2005 Moreover, the significant damping effect of sinomenine on B7-H1 and B7-DC signals could promote IL-2 and IFN-gamma production by co-cultured CD4(+) T cell. sinomenine 44-54 interferon gamma Homo sapiens 105-114 16033609-8 2005 IL-4, IL-13 and IFN-gamma play important roles in penicillin allergy. Penicillins 50-60 interferon gamma Homo sapiens 16-25 16033622-3 2005 Pimecrolimus inhibits T-cell proliferation, as well as production and release of interleukin-2 (IL-2), IL-4, interferon-gamma and tumour necrosis factor-alpha. pimecrolimus 0-12 interferon gamma Homo sapiens 109-158 16083346-2 2005 Elevated tryptophan catabolism mediated by IDO is associated with a wide variety of human cancers and has historically been thought to be a tumoricidal consequence of IFN-gamma exposure. Tryptophan 9-19 interferon gamma Homo sapiens 167-176 16093612-2 2005 We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-alpha and interferon-gamma production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. nafamostat 14-33 interferon gamma Homo sapiens 88-104 16024776-5 2005 In contrast, Fas-mediated activation of JNK, p38, and p42/44 occurred essentially independent from IFN-gamma sensitization, indicating that the apoptosis- and NF-kappaB-related FasL-IFN-gamma cross talk was not due to a simple global enhancement of Fas signaling. ammonium ferrous sulfate 13-16 interferon gamma Homo sapiens 182-191 15894584-4 2005 IFN-gamma-activated signal transducer and activator of transcription-1alpha (STAT-1alpha) suppresses MMP-9 gene transcription, which is dependent on phosphorylation of tyrosine 701 but not phosphorylation of serine 727. Tyrosine 168-176 interferon gamma Homo sapiens 0-9 15894584-4 2005 IFN-gamma-activated signal transducer and activator of transcription-1alpha (STAT-1alpha) suppresses MMP-9 gene transcription, which is dependent on phosphorylation of tyrosine 701 but not phosphorylation of serine 727. Serine 208-214 interferon gamma Homo sapiens 0-9 15840591-2 2005 Recent data have shown that 15d-PGJ2 exerts anti-inflammatory action via inhibition of the interferon gamma (IFN-gamma)-induced Jak-STAT signalling pathway. 15-deoxy-delta(12,14)-prostaglandin J2 28-36 interferon gamma Homo sapiens 91-118 15990567-6 2005 RESULTS: Absolute numbers, but not percentages, of Gag-specific IFN-gamma-, IL-2- or IFN-gamma/IL-2-producing CD4 T cells were increased in treated compared with untreated individuals up to 2 years after seroconversion. Glycosaminoglycans 51-54 interferon gamma Homo sapiens 64-73 15840591-7 2005 Inhibition was not specific for IL-10, as induction of STAT activation by IFN-gamma and IL-6 was also inhibited by 15d-PGJ2. 15-deoxy-delta(12,14)-prostaglandin J2 115-123 interferon gamma Homo sapiens 74-83 16020528-5 2005 In human epithelial cells, IFN-gamma induces indoleamine 2,3-dioxygenase expression that inhibits chlamydial growth by depleting host tryptophan pools. Tryptophan 134-144 interferon gamma Homo sapiens 27-36 15840591-14 2005 CONCLUSIONS: We showed that 15d-PGJ2 non-specifically inhibits STAT signalling of the anti-inflammatory cytokine IL-10 as well as the proinflammatory cytokine IFN-gamma. 15-deoxy-delta(12,14)-prostaglandin J2 28-36 interferon gamma Homo sapiens 159-168 15749739-8 2005 Finally, iron transport into BEAS-2B cells was increased after inclusion of TNF-alpha, IFN-gamma, or LPS in the media. Iron 9-13 interferon gamma Homo sapiens 87-96 16033848-9 2005 These data indicate that the IFN-gamma responses to U118 lysate-loaded autologous dendritic cells are glioblastoma multiforme specific. 3-(Methylthio)-1-hexanol 52-56 interferon gamma Homo sapiens 29-38 15913800-4 2005 Flow cytometry was used to investigate sequential changes of IFN-gamma producing (Th1) and interleukin-4 producing (Th2) cells from whole blood samples after stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 175-178 interferon gamma Homo sapiens 61-70 15913800-4 2005 Flow cytometry was used to investigate sequential changes of IFN-gamma producing (Th1) and interleukin-4 producing (Th2) cells from whole blood samples after stimulation with PMA and ionomycin. Ionomycin 183-192 interferon gamma Homo sapiens 61-70 15953089-7 2005 AS-101 inhibited the production of IL-10, IFNgamma, IL-2R and IL-5 in both PAA patients and controls, but there was a greater inhibitory effect in children with PAA. ammonium trichloro(dioxoethylene-O,O'-)tellurate 0-6 interferon gamma Homo sapiens 42-50 16009145-4 2005 RESULTS: Serum IL-2, IL-4, and TNF-alpha levels were significantly raised with decrease in IFN-gamma levels in the lindane-exposed cases. Hexachlorocyclohexane 115-122 interferon gamma Homo sapiens 91-100 15949937-0 2005 Involvement of both intrinsic and extrinsic pathways in IFN-gamma-induced apoptosis that are enhanced with cisplatin. Cisplatin 107-116 interferon gamma Homo sapiens 56-65 15949937-10 2005 Furthermore, together with cisplatin, IFN-gamma exerted a more powerful anti-proliferative effect. Cisplatin 27-36 interferon gamma Homo sapiens 38-47 15990776-6 2005 METHODS: Cultured HASMCs were stimulated with IL-1beta, TNF-alpha, and IFN-gamma and treated with (R)-enantiomers and (S)-enantiomers of albuterol and formoterol, with and without propranolol and ICI-118,551, and in combination with dexamethasone. hasmcs 18-24 interferon gamma Homo sapiens 71-80 16008544-5 2005 RESULTS: We found that patients with IgA antibodies towards Chlamydia lipopolysaccharide (LPS) had elevated levels of IFNgamma (P = 0.048), IL-10 (P = 0.029), TNFalpha (P = 0.009) and sE-selectin (P = 0.045), while Chlamydia LPS IgG seropositivity predicted elevated levels of IL-10 (P = 0.013). chlamydia lipopolysaccharide 60-88 interferon gamma Homo sapiens 118-126 15980236-0 2005 Down-regulation of IFN-gamma-producing CD56+ T cells after combined low-dose cyclosporine/prednisone treatment in patients with Behcet"s uveitis. Cyclosporine 77-89 interferon gamma Homo sapiens 19-28 15980236-0 2005 Down-regulation of IFN-gamma-producing CD56+ T cells after combined low-dose cyclosporine/prednisone treatment in patients with Behcet"s uveitis. Prednisone 90-100 interferon gamma Homo sapiens 19-28 15980236-12 2005 CONCLUSIONS: The results imply that Cs/Pd treatment for Behcet"s uveitis selectively affects the population of and the cytokine expression in CD56+ T cells, but without significant changes in CD56- T cells, and that IFN-gamma-producing CD56+ T cells are the central pathogenic immune cells in Behcet"s uveitis. Cesium 36-38 interferon gamma Homo sapiens 216-225 15980236-12 2005 CONCLUSIONS: The results imply that Cs/Pd treatment for Behcet"s uveitis selectively affects the population of and the cytokine expression in CD56+ T cells, but without significant changes in CD56- T cells, and that IFN-gamma-producing CD56+ T cells are the central pathogenic immune cells in Behcet"s uveitis. Palladium 39-41 interferon gamma Homo sapiens 216-225 15878863-4 2005 MLK3 appears to activate C/EBP-beta in response to IFN-gamma by a mechanism involving decreased phosphorylation of a specific phosphoacceptor residue, Ser(64), within the transactivation domain. Serine 151-154 interferon gamma Homo sapiens 51-60 15855253-4 2005 Intracellular expression of IFNgamma and IL-4 was evaluated by multicolor flow-cytometry analysis in peripheral lymphocytes in vitro stimulated by phorbol-12-myristate-13-acetate (PMA) (25 ng/ml) and ionomycin (1 mug/ml) in presence of monensin (5 microm). Tetradecanoylphorbol Acetate 147-178 interferon gamma Homo sapiens 28-36 15855253-4 2005 Intracellular expression of IFNgamma and IL-4 was evaluated by multicolor flow-cytometry analysis in peripheral lymphocytes in vitro stimulated by phorbol-12-myristate-13-acetate (PMA) (25 ng/ml) and ionomycin (1 mug/ml) in presence of monensin (5 microm). Tetradecanoylphorbol Acetate 180-183 interferon gamma Homo sapiens 28-36 15855253-4 2005 Intracellular expression of IFNgamma and IL-4 was evaluated by multicolor flow-cytometry analysis in peripheral lymphocytes in vitro stimulated by phorbol-12-myristate-13-acetate (PMA) (25 ng/ml) and ionomycin (1 mug/ml) in presence of monensin (5 microm). Ionomycin 200-209 interferon gamma Homo sapiens 28-36 15855253-4 2005 Intracellular expression of IFNgamma and IL-4 was evaluated by multicolor flow-cytometry analysis in peripheral lymphocytes in vitro stimulated by phorbol-12-myristate-13-acetate (PMA) (25 ng/ml) and ionomycin (1 mug/ml) in presence of monensin (5 microm). Monensin 236-244 interferon gamma Homo sapiens 28-36 15845643-4 2005 Stimulation of neutrophils with IFN-alpha or IFN-gamma resulted in tyrosine phosphorylation of STAT1 and STAT3 but not phosphorylation of STAT5, Akt, extracellular signal-regulated kinase, and p38 mitogen-activated protein kinase. Tyrosine 67-75 interferon gamma Homo sapiens 45-54 15942904-10 2005 CONCLUSIONS: Various polymorphisms in P2X7 abrogate IFN- gamma /ATP-induced killing of mycobacteria by human macrophages and, thus, may contribute to variability in susceptibility to mycobacterial infections. Adenosine Triphosphate 64-67 interferon gamma Homo sapiens 52-62 15979545-6 2005 RESULTS: Plasma IFNgamma concentrations in both MPB and CD compartments were significantly higher in preeclamptic than in normotensive women. 2-mercapto-1-(beta-4-pyridethyl)benzimidazole 48-51 interferon gamma Homo sapiens 16-24 15972695-5 2005 Dexamethasone significantly modulated acute cerebrospinal fluid protein concentrations and marginally reduced IFN-gamma concentrations; other immunological and routine biochemical indices of inflammation were unaffected. Dexamethasone 0-13 interferon gamma Homo sapiens 110-119 16022583-7 2005 Synthesis of IFN-gamma was induced by all mitogens and could be suppressed by catecholamines (26%-85% reduction). Catecholamines 78-92 interferon gamma Homo sapiens 13-22 16022584-3 2005 Dopamine reduced T cell proliferation, secretion of interferon-gamma (IFN-gamma), and production of matrix metalloproteinase-9 (MMP-9) mRNA in PBMCs from controls but not from MS patients. Dopamine 0-8 interferon gamma Homo sapiens 52-68 16022584-3 2005 Dopamine reduced T cell proliferation, secretion of interferon-gamma (IFN-gamma), and production of matrix metalloproteinase-9 (MMP-9) mRNA in PBMCs from controls but not from MS patients. Dopamine 0-8 interferon gamma Homo sapiens 70-79 15979545-6 2005 RESULTS: Plasma IFNgamma concentrations in both MPB and CD compartments were significantly higher in preeclamptic than in normotensive women. Cadmium 56-58 interferon gamma Homo sapiens 16-24 15908253-7 2005 Non-specific stimulation with PMA and ionomycin revealed increased frequencies of CD4+ cells expressing IFN-gamma in controls, while expression of IL-2, IL-4, IL-10, IL-13, and TNF-alpha was not different. Tetradecanoylphorbol Acetate 30-33 interferon gamma Homo sapiens 104-113 15908253-7 2005 Non-specific stimulation with PMA and ionomycin revealed increased frequencies of CD4+ cells expressing IFN-gamma in controls, while expression of IL-2, IL-4, IL-10, IL-13, and TNF-alpha was not different. Ionomycin 38-47 interferon gamma Homo sapiens 104-113 15924140-3 2005 The resulting additional carbohydrate moiety was both necessary and sufficient to abolish the cellular response to IFNgamma. Carbohydrates 25-37 interferon gamma Homo sapiens 115-123 15989786-6 2005 CONCLUSION: RA can up-regulate the expression of C3 and Bf of A549 cells induced with TNF-alpha, IL-1beta, IL-6 and IFN-gamma, and regulate the immunological defence of local lung tissue, which provides a theoretical basis for prevention and treatment of pulmonary diseases by using RA and cytokines. Radium 12-14 interferon gamma Homo sapiens 116-125 15937107-9 2005 Furthermore, hGBP-1 requires another IFN-gamma-induced factor to be targeted to the Golgi, because constitutively expressed hGBP-1 remained cytosolic in cells treated with aluminum fluoride unless the cells were preincubated with IFN-gamma. aluminum fluoride 172-189 interferon gamma Homo sapiens 37-46 15937107-9 2005 Furthermore, hGBP-1 requires another IFN-gamma-induced factor to be targeted to the Golgi, because constitutively expressed hGBP-1 remained cytosolic in cells treated with aluminum fluoride unless the cells were preincubated with IFN-gamma. aluminum fluoride 172-189 interferon gamma Homo sapiens 230-239 15932518-5 2005 In vivo, preventive HO-1 induction by CoPP in acute dextran sodium sulphate (DSS)-induced colitis led to a significant down-regulation of colonic inflammation (P < 0.01) with a concomitant reduction in interferon (IFN)-gamma - but unaffected interleukin (IL)-10-secretion by isolated mesenteric lymph nodes (P < 0.01). dextran sodium sulphate 52-75 interferon gamma Homo sapiens 205-227 21190613-0 2005 [Experimental study of effects of retinoic acid on IL-1beta and IFN-gamma induced C3 and factor B secretion in lung cancer cell line]. Tretinoin 34-47 interferon gamma Homo sapiens 64-73 21190613-2 2005 The aim of this study is to investigate the regulated effects of retinoic acid (RA) on IL-1beta and IFN-gamma induced C3 and factor B secretion in human lung cancer cell line A549. Tretinoin 65-78 interferon gamma Homo sapiens 100-109 21190613-2 2005 The aim of this study is to investigate the regulated effects of retinoic acid (RA) on IL-1beta and IFN-gamma induced C3 and factor B secretion in human lung cancer cell line A549. Tretinoin 80-82 interferon gamma Homo sapiens 100-109 21190613-6 2005 CONCLUSIONS: RA can up-regulate C3 and factor B secretion induced by IL-1beta and IFN-gamma in human lung cancer cell A549. Tretinoin 13-15 interferon gamma Homo sapiens 82-91 15896467-1 2005 Tryptophan degradation by the enzyme indoleamine-(2,3)-dioxy genase (IDO) and neopterin production are induced within cellular immune activation by stimulation of monocyte-derived macrophages and dendritic cells with cytokine interferon-gamma. Tryptophan 0-10 interferon gamma Homo sapiens 226-242 15896467-1 2005 Tryptophan degradation by the enzyme indoleamine-(2,3)-dioxy genase (IDO) and neopterin production are induced within cellular immune activation by stimulation of monocyte-derived macrophages and dendritic cells with cytokine interferon-gamma. Neopterin 78-87 interferon gamma Homo sapiens 226-242 15968830-3 2005 Judging by the cytokine production of interleukin-2 and interferon-gamma in peripheral blood mononuclear cells stimulated by phorbol-myristate-acetate (PMA) and ionomycin, immunosuppressive drugs given for rheumatic disorders during pregnancy do not induce significant immunosuppression in babies. Tetradecanoylphorbol Acetate 125-150 interferon gamma Homo sapiens 56-72 15968830-3 2005 Judging by the cytokine production of interleukin-2 and interferon-gamma in peripheral blood mononuclear cells stimulated by phorbol-myristate-acetate (PMA) and ionomycin, immunosuppressive drugs given for rheumatic disorders during pregnancy do not induce significant immunosuppression in babies. Tetradecanoylphorbol Acetate 152-155 interferon gamma Homo sapiens 56-72 15968830-3 2005 Judging by the cytokine production of interleukin-2 and interferon-gamma in peripheral blood mononuclear cells stimulated by phorbol-myristate-acetate (PMA) and ionomycin, immunosuppressive drugs given for rheumatic disorders during pregnancy do not induce significant immunosuppression in babies. Ionomycin 161-170 interferon gamma Homo sapiens 56-72 15932518-5 2005 In vivo, preventive HO-1 induction by CoPP in acute dextran sodium sulphate (DSS)-induced colitis led to a significant down-regulation of colonic inflammation (P < 0.01) with a concomitant reduction in interferon (IFN)-gamma - but unaffected interleukin (IL)-10-secretion by isolated mesenteric lymph nodes (P < 0.01). dss 77-80 interferon gamma Homo sapiens 205-227 15932627-0 2005 Promoter and intron-1 region polymorphisms in the IFNG gene in patients with hepatitis E. Allelic and genotype variations in the promoter region and the dinucleotide (CA)(n) repeat region in intron 1 of the interferon-g (IFNG) gene were analysed by direct sequencing and simple sequence length polymorphism (SSLP), respectively, in patients with acute hepatitis, and the prevalence was compared with that in healthy controls. Dinucleoside Phosphates 153-165 interferon gamma Homo sapiens 50-54 15958315-1 2005 OBJECTIVE: To study the effect of bicyclol tablets on the levels of interleukin (IL)-4, IL-10 and interferon (IFN)-gamma in culture supernatants of peripheral blood mononuclear cells (PBMCs) from patients with chronic hepatitis B (CHB). bicyclol 34-42 interferon gamma Homo sapiens 98-120 15937058-6 2005 Cross-linking CD4 molecules (XLCD4) with anti-CD4 mAbs and goat anti-mouse IgG (GAM) resulted in high levels of IL-6, TNF-alpha and IFN-gamma but no IL-10 production by CD14(+) monocytes. xlcd4 29-34 interferon gamma Homo sapiens 132-141 15728714-3 2005 We found that proinflammatory mediators, such as interferon-gamma (IFN-gamma), tumor necrosis factor-alpha, and LPS, down-regulated expression, whereas the anti-inflammatory cytokine, interleukin-10, and dexamethasone up-regulated BLT1 mRNA expression. Dexamethasone 204-217 interferon gamma Homo sapiens 49-65 15728714-3 2005 We found that proinflammatory mediators, such as interferon-gamma (IFN-gamma), tumor necrosis factor-alpha, and LPS, down-regulated expression, whereas the anti-inflammatory cytokine, interleukin-10, and dexamethasone up-regulated BLT1 mRNA expression. Dexamethasone 204-217 interferon gamma Homo sapiens 67-76 15919923-5 2005 SIV Gag-specific T-cell responses were detected in peripheral blood by MHC class I tetramer staining (peak, 0.07 to 0.2% CD8(+) T cells at week 2) and gamma interferon (IFN-gamma) enzyme-linked immunospot (ELISPOT) assays (peak, 50 to 250 spot forming cells/10(6) peripheral blood mononuclear cell at week 3). Glycosaminoglycans 4-7 interferon gamma Homo sapiens 151-178 15905551-4 2005 In this study we show that rocaglamides are potent immunosuppressive phytochemicals that suppress IFN-gamma, TNF-alpha, IL-2, and IL-4 production in peripheral blood T cells at nanomolar concentrations. rocaglamide 27-39 interferon gamma Homo sapiens 98-107 15919929-4 2005 The antiviral activity induced by IFN-gamma correlates with the induction of indoleamine 2,3-dioxygenase (IDO), an enzyme of the tryptophan degradation pathway known to mediate antiviral as well as antibacterial and antiparasitic effects. Tryptophan 129-139 interferon gamma Homo sapiens 34-43 15919929-5 2005 The IFN-gamma-induced antiviral activity can be overcome by the addition of excess amounts of l-tryptophan, which indicates a specific role of IDO in the anti-MV activity. Tryptophan 94-106 interferon gamma Homo sapiens 4-13 16008914-2 2005 METHODS: Using lipofectAMINE, IFN-gamma gene was transferred to human Tenon"s capsule fibroblasts with plasmid pcDNA3IFN-gamma in vitro. Lipofectamine 15-28 interferon gamma Homo sapiens 30-39 15882256-10 2005 Losartan also decreased IFN-gamma production (P < 0.001) in purified alloreactive T cells in vitro as did candesartan. Losartan 0-8 interferon gamma Homo sapiens 24-33 15943592-4 2005 This study in 16 children with moderate asthma was designed to assess whether there exists day and night differences in IL-4, IL-5, IL-8, and IFN-gamma production of concanavaline A stimulated peripheral blood mononuclear cells. concanavaline a 166-181 interferon gamma Homo sapiens 142-151 15883169-7 2005 IFN-gamma induced increasing levels of tyrosine-phosphorylated STAT2 in M27(-) MCMV-infected cells that were essential for the antiviral potency of IFN-gamma. Tyrosine 39-47 interferon gamma Homo sapiens 0-9 15778222-8 2005 3-Methyladenine or expression of Atg5(K130R) mutant blocks both cell death and vacuole formation triggered by IFN-gamma, whereas benzyloxycarbonyl-VAD-fluoromethyl ketone (Z-VAD-fmk) inhibits only cell death but not vacuole formation. 3-methyladenine 0-15 interferon gamma Homo sapiens 110-119 15883169-7 2005 IFN-gamma induced increasing levels of tyrosine-phosphorylated STAT2 in M27(-) MCMV-infected cells that were essential for the antiviral potency of IFN-gamma. Tyrosine 39-47 interferon gamma Homo sapiens 148-157 15601262-3 2005 MEKK4 is tyrosine-phosphorylated and the IFNgamma-dependent phosphorylation requires intracellular calcium. Calcium 99-106 interferon gamma Homo sapiens 41-49 15601262-0 2005 Interferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes. Tyrosine 27-35 interferon gamma Homo sapiens 0-16 15601262-7 2005 Immunofluorescence imaging of HaCaT cells shows an IFNgamma-dependent co-localization of annexin II with Pyk2 in the perinuclear region, suggesting that annexin II mediates the calcium-dependent regulation of Pyk2. Calcium 177-184 interferon gamma Homo sapiens 51-59 15601262-8 2005 Tyrosine phosphorylation of MEKK4 correlates with its activity to phosphorylate MKK6 (MAPK kinase 6) in vitro and subsequent p38 MAPK activation in an IFNgamma-dependent manner. Tyrosine 0-8 interferon gamma Homo sapiens 151-159 15879136-0 2005 Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen. Cyclic AMP 0-10 interferon gamma Homo sapiens 79-88 15760905-0 2005 Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production. Polysaccharides 66-72 interferon gamma Homo sapiens 107-123 15760905-0 2005 Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production. Glycosylphosphatidylinositols 30-58 interferon gamma Homo sapiens 107-123 15760905-7 2005 Phosphatidylinositol-specific phospholipase C treatment inhibited the phosphorylation of tyrosine kinases and the following IL-18-dependent interferon-gamma production. Phosphatidylinositols 0-20 interferon gamma Homo sapiens 140-156 15934873-6 2005 In this field there are interesting developments using topical retinoids and gene therapy products, such as adeno-IFN-gamma. Retinoids 63-72 interferon gamma Homo sapiens 114-123 15723092-4 2005 Inhibition of NHE activity by IFN-gamma was absent in cariporide-treated cells, but not in cells treated with S-3226. cariporide 54-64 interferon gamma Homo sapiens 30-39 15723092-6 2005 Inhibition of Raf1, mitogen-activated protein kinase kinase (MAPKK/MEK) and p38 MAPK with, respectively, GW 5074, PD 98059 and SB 203580 and downregulation of protein kinase C (PKC) with phorbol-12,13-dibutyrate (100 nM for 24 h) prevented inhibition of NHE activity by IFN-gamma (0.5 and 24 h exposure). glycyltryptophan 105-107 interferon gamma Homo sapiens 270-279 15723092-7 2005 The signal transducer and activator transcription factor 1 (STAT1) inhibitor epigallocatechin-3-gallate (EGCG) prevented inhibition of NHE activity by long- but not the short-term treatment with IFN-gamma. epigallocatechin gallate 105-109 interferon gamma Homo sapiens 195-204 15723092-8 2005 Treatment with IFN-gamma activated phospho-p38 MAPK, this effect being detected as early as 1 h, persisting over 3 h and decreasing after 24 h. IFN-gamma produced a sustained action of phospho-STAT1 that was prevented by EGCG and partially attenuated by SB 203580 and insensitive to downregulation of PKC. epigallocatechin gallate 221-225 interferon gamma Homo sapiens 15-24 15723092-8 2005 Treatment with IFN-gamma activated phospho-p38 MAPK, this effect being detected as early as 1 h, persisting over 3 h and decreasing after 24 h. IFN-gamma produced a sustained action of phospho-STAT1 that was prevented by EGCG and partially attenuated by SB 203580 and insensitive to downregulation of PKC. epigallocatechin gallate 221-225 interferon gamma Homo sapiens 144-153 15723092-8 2005 Treatment with IFN-gamma activated phospho-p38 MAPK, this effect being detected as early as 1 h, persisting over 3 h and decreasing after 24 h. IFN-gamma produced a sustained action of phospho-STAT1 that was prevented by EGCG and partially attenuated by SB 203580 and insensitive to downregulation of PKC. SB 203580 254-263 interferon gamma Homo sapiens 15-24 15723092-8 2005 Treatment with IFN-gamma activated phospho-p38 MAPK, this effect being detected as early as 1 h, persisting over 3 h and decreasing after 24 h. IFN-gamma produced a sustained action of phospho-STAT1 that was prevented by EGCG and partially attenuated by SB 203580 and insensitive to downregulation of PKC. SB 203580 254-263 interferon gamma Homo sapiens 144-153 15892581-2 2005 At relatively low doses, STZ-induced beta cell destruction is associated with Th1-driven type 1 immune reactions, including macrophages (MPhi) and IFN-gamma-producing CD8(+) T cells. Streptozocin 25-28 interferon gamma Homo sapiens 147-156 15892581-4 2005 Results show that elimination of MPhi with clodronate-containing liposomes prior to exposure to STZ prevents the occurrence of some (CD8(+) T cell activation, IFN-gamma production, and tissue destruction) but not all (IgG2a formation) type 1 immune responses. Clodronic Acid 43-53 interferon gamma Homo sapiens 159-168 16004257-1 2005 Individual and combined effects of chorionic gonadotropin (CG), estradiol, and progesterone on the production of IFNgamma and IL-4 by human peripheral blood lymphocytes was studied in vitro together with certain intracellular mechanisms underlying the hormonal effects. Progesterone 79-91 interferon gamma Homo sapiens 113-121 15887109-11 2005 Interferon gamma-mediated bacterial translocation was abolished by pretreatment with the cholesterol-disrupting drugs filipin and methyl-beta-cyclodextrin, whereas these agents had no effect on infection of Caco-2 by the enteric pathogen Shigella sonnei. Cholesterol 89-100 interferon gamma Homo sapiens 0-16 15887109-11 2005 Interferon gamma-mediated bacterial translocation was abolished by pretreatment with the cholesterol-disrupting drugs filipin and methyl-beta-cyclodextrin, whereas these agents had no effect on infection of Caco-2 by the enteric pathogen Shigella sonnei. methyl-beta-cyclodextrin 130-154 interferon gamma Homo sapiens 0-16 15778120-4 2005 Furthermore, blocking ERK1/2 activation with the specific inhibitor, PD098059, inhibited cytolytic activity in both cell lines and reduced mRNA expression of cytolysis-related effector molecules such as Fas-L and IFN gamma, as measured by semi-quantitative RT-PCR. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 69-77 interferon gamma Homo sapiens 213-222 15806306-0 2005 IFN-gamma/JAK/STAT pathway-induced inhibition of DR4 and DR5 expression on endothelial cells is cancelled by cycloheximide-sensitive mechanism: novel finding of cycloheximide-regulating death receptor expression. Cycloheximide 109-122 interferon gamma Homo sapiens 0-9 15806306-6 2005 IFN-gamma/JAK/STAT-induced suppression was regulated by cycloheximide (CHX)-sensitive mechanism since the use of CHX mimicked the action of chemical inhibition of JAK in regard to DR4/DR5 expression as well as TRAIL-mediated endothelial cell apoptosis. Cycloheximide 56-69 interferon gamma Homo sapiens 0-9 15806306-6 2005 IFN-gamma/JAK/STAT-induced suppression was regulated by cycloheximide (CHX)-sensitive mechanism since the use of CHX mimicked the action of chemical inhibition of JAK in regard to DR4/DR5 expression as well as TRAIL-mediated endothelial cell apoptosis. Cycloheximide 71-74 interferon gamma Homo sapiens 0-9 16004257-3 2005 In contrast, progesterone (100 ng/ml) increased IFNgamma production by activated T lymphocytes but proved inefficient in a physiological combination with CG and estradiol. Progesterone 13-25 interferon gamma Homo sapiens 48-56 16004257-5 2005 Inhibition analysis employing blockers of cAMP-dependent protein kinase (H-89) and L-type calcium channels (verapamil) as well as an antagonist of progesterone nuclear receptors (RU-486) demonstrated that the inhibitory (for IFNgamma) and stimulatory (for IL-4) effects of CG were mediated by cAMP, while the effects of steroid hormones on the production of these cytokines were realized through genomic and non-genomic mechanisms (the latter mechanisms were largely mediated by L-type calcium channel regulation). Verapamil 108-117 interferon gamma Homo sapiens 225-233 16004257-5 2005 Inhibition analysis employing blockers of cAMP-dependent protein kinase (H-89) and L-type calcium channels (verapamil) as well as an antagonist of progesterone nuclear receptors (RU-486) demonstrated that the inhibitory (for IFNgamma) and stimulatory (for IL-4) effects of CG were mediated by cAMP, while the effects of steroid hormones on the production of these cytokines were realized through genomic and non-genomic mechanisms (the latter mechanisms were largely mediated by L-type calcium channel regulation). Mifepristone 179-185 interferon gamma Homo sapiens 225-233 16004257-5 2005 Inhibition analysis employing blockers of cAMP-dependent protein kinase (H-89) and L-type calcium channels (verapamil) as well as an antagonist of progesterone nuclear receptors (RU-486) demonstrated that the inhibitory (for IFNgamma) and stimulatory (for IL-4) effects of CG were mediated by cAMP, while the effects of steroid hormones on the production of these cytokines were realized through genomic and non-genomic mechanisms (the latter mechanisms were largely mediated by L-type calcium channel regulation). Steroids 320-336 interferon gamma Homo sapiens 225-233 15942713-11 2005 The IFN-gamma-induced IP-10 secretion was not affected by acetate or propionate, but was significantly reduced by butyrate. Butyrates 114-122 interferon gamma Homo sapiens 4-13 15867854-5 2005 A screening of various factors (histamine, IFN-gamma, IL-1beta, IL-2, IL-3, IL-4, IL-5, IL-8, IL-12, and TNF-alpha) identified IFN-gamma as a potent factor capable of reducing epithelial barrier properties and enhancing transepithelial allergen penetration. Histamine 32-41 interferon gamma Homo sapiens 127-136 15867854-6 2005 Increased submucosal allergen concentrations caused by IFN-gamma-mediated reduction of epithelial barrier function provoked a more than 7-fold augmentation of histamine release from sensitized basophils. Histamine 159-168 interferon gamma Homo sapiens 55-64 15770663-0 2005 Interferon gamma promotes survival of lymphoblasts overexpressing 9-O-acetylated sialoglycoconjugates in childhood acute lymphoblastic leukaemia (ALL). 9-o 66-69 interferon gamma Homo sapiens 0-16 15770663-9 2005 Taken together, it is reasonable to hypothesise that O-acetylation of sialic acids on PBMC(ALL) may be an additional mechanism that promotes the survival of lymphoblasts by avoiding apoptosis via IFN-gamma-induced NO production. Sialic Acids 70-82 interferon gamma Homo sapiens 196-205 15942713-12 2005 Trichostatin A, a specific inhibitor of histone deacetylase, also blocked the IFN-gamma- and TNF-alpha-induced IP-10 mRNA expression, but the effects of trichostatin A were weaker than those of butyrate. trichostatin A 0-14 interferon gamma Homo sapiens 78-87 15942713-12 2005 Trichostatin A, a specific inhibitor of histone deacetylase, also blocked the IFN-gamma- and TNF-alpha-induced IP-10 mRNA expression, but the effects of trichostatin A were weaker than those of butyrate. trichostatin A 153-167 interferon gamma Homo sapiens 78-87 15942713-13 2005 The inhibitory effect of butyrate on IFN-gamma-induced IP-10 release was not associated with STAT (signaling transducer and activator of transcription)-1alpha activation. Butyrates 25-33 interferon gamma Homo sapiens 37-46 15809765-0 2005 IFN-gamma enhances paclitaxel-induced apoptosis that is modulated by activation of caspases 8 and 3 with a concomitant down regulation of the AKT survival pathway in cultured human keratinocytes. Paclitaxel 19-29 interferon gamma Homo sapiens 0-9 15833366-0 2005 Interferon-gamma and interferon-beta affect endogenous catecholamines in human peripheral blood mononuclear cells: implications for multiple sclerosis. Catecholamines 55-69 interferon gamma Homo sapiens 0-16 15809765-10 2005 The induction of apoptosis in paclitaxel-treated cells is enhanced by coadministration of IFN-gamma. Paclitaxel 30-40 interferon gamma Homo sapiens 90-99 15809765-11 2005 The synergistic effect of these two agents on HaCaT cells relies on a pathway involving caspases 8 and 3, with activity increasing by 48 h. Collectively, our data indicate that i) paclitaxel-induced apoptosis is enhanced by IFN-gamma; ii) the down-regulation of PI3-K/AKT survival pathway may help potentiate the apoptotic effects of paclitaxel and iii) the apoptotic signaling pathways are initiated with the activation of caspases 8 and 3 activities. Paclitaxel 180-190 interferon gamma Homo sapiens 224-233 15809765-11 2005 The synergistic effect of these two agents on HaCaT cells relies on a pathway involving caspases 8 and 3, with activity increasing by 48 h. Collectively, our data indicate that i) paclitaxel-induced apoptosis is enhanced by IFN-gamma; ii) the down-regulation of PI3-K/AKT survival pathway may help potentiate the apoptotic effects of paclitaxel and iii) the apoptotic signaling pathways are initiated with the activation of caspases 8 and 3 activities. Paclitaxel 334-344 interferon gamma Homo sapiens 224-233 15821391-5 2005 Gag-specific T cells mainly secrete interleukin-2 in ESN and interferon-gamma in HIV patients. Glycosaminoglycans 0-3 interferon gamma Homo sapiens 61-77 16220783-7 2005 The enhancing effects of histamine and IFN-gamma on MCP-1 protein production were significantly inhibited by cetirizine (1 and 10 micromol x L(-1)) in DF and HaCaT cells. Cetirizine 109-119 interferon gamma Homo sapiens 39-48 15863363-1 2005 The present study shows that the incubation of human aortic smooth muscle cells (HASMC) and HepG2 cells with atorvastatin and mevastatin as HMG-CoA reductase inhibitors potentiated the interferon-gamma (INF-gamma)-induced group IIA phospholipase A(2) (sPLA(2)-IIA) expression in a dose- and time-dependent manner. Atorvastatin 109-121 interferon gamma Homo sapiens 185-201 15863363-1 2005 The present study shows that the incubation of human aortic smooth muscle cells (HASMC) and HepG2 cells with atorvastatin and mevastatin as HMG-CoA reductase inhibitors potentiated the interferon-gamma (INF-gamma)-induced group IIA phospholipase A(2) (sPLA(2)-IIA) expression in a dose- and time-dependent manner. mevastatin 126-136 interferon gamma Homo sapiens 185-201 15863363-6 2005 Further, the Janus kinase-2 (Jak2)-specific inhibitor, AG-490 and inhibitors of nuclear factor-kappaB (NFkappaB) abrogated the sPLA(2)-IIA elevating effects of statins, TcdB and PD98059 in the presence of IFN-gamma. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 55-61 interferon gamma Homo sapiens 205-214 15863363-8 2005 Moreover, after the incubation of cells with atorvastatin and IFN-gamma the stability of sPLA-(2)IIA mRNA significantly increased in comparison to those after incubation with IFN-gamma alone. Atorvastatin 45-57 interferon gamma Homo sapiens 175-184 15818511-9 2005 The percentage of AL correlated significantly with serum levels of neopterin (r=0.446, p<0.05, n=22) and SLAM score (r=0.533, p<0.001, n=38), but not with the serum levels of IFN-gamma. Aluminum 18-20 interferon gamma Homo sapiens 181-190 15814691-0 2005 Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells. Glucose 0-7 interferon gamma Homo sapiens 31-40 15814691-6 2005 Together, our data reveal that optimal induction of IFN-gamma transcription is a glucose-dependent process, indicate that there are undefined factors that influence IFN-gamma expression, and have implications for regulation of the effector phase of CD8+ T cell responses in tissue microenvironments. Glucose 81-88 interferon gamma Homo sapiens 52-61 15943174-5 2005 Moreover, 10(-4) and 10(-5) M Zn and 10(-5) M Se strongly upregulated IFN-gamma (a Th1 cytokine) release, even in presence of 10(-5) M Cd, and reduced the inhibitory effects of Cd on PBMC proliferation and TNF-alpha release. Zinc 30-32 interferon gamma Homo sapiens 70-79 15943174-5 2005 Moreover, 10(-4) and 10(-5) M Zn and 10(-5) M Se strongly upregulated IFN-gamma (a Th1 cytokine) release, even in presence of 10(-5) M Cd, and reduced the inhibitory effects of Cd on PBMC proliferation and TNF-alpha release. Cadmium 177-179 interferon gamma Homo sapiens 70-79 15762873-4 2005 In parallel, IFN-gamma induces enzyme GTP-cyclohydrolase I, which gives rise to neopterin production by activated human macrophages. Neopterin 80-89 interferon gamma Homo sapiens 13-22 15762873-12 2005 The influence of aspirin on biochemical pathways induced by IFN-gamma may represent an important part of its broad pharmacological effect. Aspirin 17-24 interferon gamma Homo sapiens 60-69 15849849-4 2005 In vitro IFN-gamma and IL-4 secretion by peripheral blood mononuclear cells after stimulation with ionomycin and phorbol 12 myristate 13 acetate was measured by enzyme-linked immunosorbent assay (ELISA) tests. Ionomycin 99-108 interferon gamma Homo sapiens 9-18 15849849-4 2005 In vitro IFN-gamma and IL-4 secretion by peripheral blood mononuclear cells after stimulation with ionomycin and phorbol 12 myristate 13 acetate was measured by enzyme-linked immunosorbent assay (ELISA) tests. Tetradecanoylphorbol Acetate 113-144 interferon gamma Homo sapiens 9-18 15749732-6 2005 IFN-gamma further significantly up-regulated its expression, which, however, was inhibited by CsA. Cyclosporine 94-97 interferon gamma Homo sapiens 0-9 15777344-3 2005 CsA induced the apoptosis of ECFCs in the presence of EPO or IFN-gamma, but at different magnitudes. Cyclosporine 0-3 interferon gamma Homo sapiens 61-70 15777344-9 2005 CsA disturbed the transmembrane potential in the presence of either EPO or IFN-gamma, although the viability of the cells was maintained in the presence of IFN-gamma plus CsA. Cyclosporine 0-3 interferon gamma Homo sapiens 75-84 15795123-9 2005 RESULTS: Nadifloxacin as well as macrolide antibiotics and clindamycin inhibited IL-12 and IFN-gamma production by PBMC stimulated by heat-killed P. acnes. nadifloxacin 9-21 interferon gamma Homo sapiens 91-100 15795123-9 2005 RESULTS: Nadifloxacin as well as macrolide antibiotics and clindamycin inhibited IL-12 and IFN-gamma production by PBMC stimulated by heat-killed P. acnes. macrolide antibiotics 33-54 interferon gamma Homo sapiens 91-100 15795123-9 2005 RESULTS: Nadifloxacin as well as macrolide antibiotics and clindamycin inhibited IL-12 and IFN-gamma production by PBMC stimulated by heat-killed P. acnes. Clindamycin 59-70 interferon gamma Homo sapiens 91-100 15778340-2 2005 In this report, we first demonstrate that the downstream effects induced by alpha-galactosylceramide activated NK T cells on NK cells are mainly dependent on IFN-gamma. alpha-galactosylceramide 76-100 interferon gamma Homo sapiens 158-167 15778396-3 2005 Our results demonstrate that in the presence of APCs, beryllium induced strong proliferation responses of BAL CD4(+) T cells, production of superoptimal concentrations of secreted proinflammatory cytokines, IFN-gamma, TNF-alpha,and IL-2, and up-regulation of numerous T cell surface markers that would promote T-T Ag presentation. Beryllium 54-63 interferon gamma Homo sapiens 207-216 15816837-0 2005 Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor necrosis factor-alpha and interferon-gamma in human epidermis. Ceramides 44-52 interferon gamma Homo sapiens 151-167 15695523-6 2005 IFN-gamma-induced neurite outgrowth was abolished by the treatment of MEK1/2 kinase inhibitors, such as U0126 and PD98059, which inhibit the ERK1/2 activation and subsequently prevent the up-regulation of p35 expression and Cdk5 activity. U 0126 104-109 interferon gamma Homo sapiens 0-9 15695523-6 2005 IFN-gamma-induced neurite outgrowth was abolished by the treatment of MEK1/2 kinase inhibitors, such as U0126 and PD98059, which inhibit the ERK1/2 activation and subsequently prevent the up-regulation of p35 expression and Cdk5 activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-121 interferon gamma Homo sapiens 0-9 15816837-5 2005 Levels of transcripts for acid-SMase and GCase and the amount of ceramide in human epidermal sheets were enhanced by tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma and these effects were inhibited in the presence of interleukin (IL)-4. Ceramides 65-73 interferon gamma Homo sapiens 155-177 15795279-10 2005 Finally, the blocking of the IFN-alpha and IFN-gamma by neutralizing antibodies led to the complete inhibition of tyrosine phosphorylation of STAT1. Tyrosine 114-122 interferon gamma Homo sapiens 43-52 16128038-1 2005 Neopterin released by monocytes/macrophages upon activation by interferon-gamma secreted from T-lymphocytes, is a sensitive indicator of cell-mediated immune activation. Neopterin 0-9 interferon gamma Homo sapiens 63-79 15853916-7 2005 Addition of LACK to SLA-stimulated cultures decreased IFN-gamma levels by 58% in CL patients and by 30% in ML patients. (S)-lipoic acid 20-23 interferon gamma Homo sapiens 54-63 15853924-0 2005 Association of interferon-gamma +874(T/A) single nucleotide polymorphism with the rate of tryptophan catabolism in healthy individuals. Tryptophan 90-100 interferon gamma Homo sapiens 15-31 15853924-5 2005 To this end, we analysed the IFN-gamma+874(T/A) genotypes, which are known to have an effect on IFN-gamma production, of 309 healthy blood donors and correlated these to the levels of trp and kyn in their blood. Tryptophan 184-187 interferon gamma Homo sapiens 29-38 15853924-7 2005 These data show that trp catabolism is genetically controlled by the IFN-gamma gene and may thus be operative in those disease conditions associated with the polymorphisms of the IFN-gamma gene. Tryptophan 21-24 interferon gamma Homo sapiens 69-78 15853924-7 2005 These data show that trp catabolism is genetically controlled by the IFN-gamma gene and may thus be operative in those disease conditions associated with the polymorphisms of the IFN-gamma gene. Tryptophan 21-24 interferon gamma Homo sapiens 179-188 15735741-3 2005 This novel effect may provide important clues to explain the anticancer effects of DIM because it is well known that IFNgamma plays an important role in preventing the development of primary and transplanted tumors. 3,3'-diindolylmethane 83-86 interferon gamma Homo sapiens 117-125 16052848-0 2005 The effect of cetirizine on IFN-gamma and IL-10 production in children with allergic rhinitis. Cetirizine 14-24 interferon gamma Homo sapiens 28-37 16052848-9 2005 In addition, IFN-gamma/IL-4 ratio increased following cetirizine treatment. Cetirizine 54-64 interferon gamma Homo sapiens 13-22 16052848-10 2005 Cetirizine induced a shift in the human Th1/Th2 cytokine balance toward a Th1 type response by increasing IFN-gamma production and augmenting suppressor cytokine release (IL-10). Cetirizine 0-10 interferon gamma Homo sapiens 106-115 15735741-7 2005 These results establish that DIM-induced IFNgamma expression in human breast tumor cells is mediated by activation of both JNK and p38 pathways, which is ultimately dependent on intracellular calcium signaling. Calcium 192-199 interferon gamma Homo sapiens 41-49 15721216-3 2005 Immunostimulation with LPS+IFN-gamma induced the sustained activation of ERK1/2 for up to 48 h. Glucose deprivation caused the loss of ATP and consequently cell death in immunostimulated astroglia, which was significantly blocked by the treatment with the ERK kinase (MEK1) inhibitor, PD98059 (10-40 microM), to inhibit the ERK1/2 pathways. Adenosine Triphosphate 135-138 interferon gamma Homo sapiens 27-36 15721216-3 2005 Immunostimulation with LPS+IFN-gamma induced the sustained activation of ERK1/2 for up to 48 h. Glucose deprivation caused the loss of ATP and consequently cell death in immunostimulated astroglia, which was significantly blocked by the treatment with the ERK kinase (MEK1) inhibitor, PD98059 (10-40 microM), to inhibit the ERK1/2 pathways. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 285-292 interferon gamma Homo sapiens 27-36 15753310-1 2005 IFN-gamma treatment of cells leads to tyrosine phosphorylation of signal transducer and activator of transcription (STAT) 1 followed by dimerization through a reciprocal Src homology 2-phosphotyrosine interaction near the -COOH end of each monomer, forming a parallel structure that accumulates in the nucleus to drive transcription. Tyrosine 38-46 interferon gamma Homo sapiens 0-9 15753310-1 2005 IFN-gamma treatment of cells leads to tyrosine phosphorylation of signal transducer and activator of transcription (STAT) 1 followed by dimerization through a reciprocal Src homology 2-phosphotyrosine interaction near the -COOH end of each monomer, forming a parallel structure that accumulates in the nucleus to drive transcription. 2-phosphotyrosine 183-200 interferon gamma Homo sapiens 0-9 15753310-1 2005 IFN-gamma treatment of cells leads to tyrosine phosphorylation of signal transducer and activator of transcription (STAT) 1 followed by dimerization through a reciprocal Src homology 2-phosphotyrosine interaction near the -COOH end of each monomer, forming a parallel structure that accumulates in the nucleus to drive transcription. Carbonic Acid 223-227 interferon gamma Homo sapiens 0-9 15707399-6 2005 Everolimus reduced IFN-gamma secretion by CD4(+)CD25(-) cells before the anti-proliferative effect: this is a novel finding. Everolimus 0-10 interferon gamma Homo sapiens 19-28 16146335-7 2005 Thalidomide stimulates the Th-1 response increasing IFN-gamma levels while CC-4047 increased IL-2 as well. Thalidomide 0-11 interferon gamma Homo sapiens 52-61 15715934-0 2005 Diethyldithiocarbamate inhibits iNOS expression in human lens epithelial cells stimulated by IFN-gamma and LPS. Ditiocarb 0-22 interferon gamma Homo sapiens 93-102 15715934-6 2005 CONCLUSION: The expression of iNOS in HLEC needs co-stimulation with IFN-gamma and LPS and it is inhibited by DDC. Ditiocarb 110-113 interferon gamma Homo sapiens 69-78 15486347-0 2005 Nitric oxide mediates increased P-glycoprotein activity in interferon-{gamma}-stimulated human intestinal cells. Nitric Oxide 0-12 interferon gamma Homo sapiens 59-76 15486347-3 2005 IFN-gamma reduced cellular uptake of cyclosporin A (CysA) but not methotrexate (MTX) in a time- and concentration-dependent manner. Cyclosporine 37-50 interferon gamma Homo sapiens 0-9 15486347-3 2005 IFN-gamma reduced cellular uptake of cyclosporin A (CysA) but not methotrexate (MTX) in a time- and concentration-dependent manner. Cyclosporine 52-56 interferon gamma Homo sapiens 0-9 15486347-5 2005 Coincubation with the inducible NO synthase inhibitor l-N(6)-(1-iminoethyl)lysine (l-NIL) dramatically reduced production of intracellular NO in response to IFN-gamma stimulus. N(6)-(1-iminoethyl)lysine 54-81 interferon gamma Homo sapiens 157-166 15486347-5 2005 Coincubation with the inducible NO synthase inhibitor l-N(6)-(1-iminoethyl)lysine (l-NIL) dramatically reduced production of intracellular NO in response to IFN-gamma stimulus. N(6)-(1-iminoethyl)lysine 83-88 interferon gamma Homo sapiens 157-166 15749687-3 2005 Forward logistic regression analysis confirmed the role of IFN-gamma 3/3 genotype as one of the risk factors for manifestation of chronic GvHD (OR=3.180, p=0.018) together with previous acute GvHD (OR=2.752, p=0.024), cyclosporine A monotherapy (OR=2.607, p=0.029) and malignant disorders (OR=4.371, p=0.032). Cyclosporine 218-232 interferon gamma Homo sapiens 59-68 15830723-7 2005 Also, the adsorption of IFN-gamma onto these carriers was able to improve the priming effects of IFN-gamma on the nitric oxide production (NO) by RAW macrophages. Nitric Oxide 114-126 interferon gamma Homo sapiens 24-33 15830723-7 2005 Also, the adsorption of IFN-gamma onto these carriers was able to improve the priming effects of IFN-gamma on the nitric oxide production (NO) by RAW macrophages. Nitric Oxide 114-126 interferon gamma Homo sapiens 97-106 15716663-9 2005 RESULTS: Continuously stimulated colonic cells had increased ROS production, especially those stimulated with TNF-alpha or IFN-gamma/TNF-alpha (P<0.001). Reactive Oxygen Species 61-64 interferon gamma Homo sapiens 123-132 15722640-5 2005 We further analyzed the IFN-gamma effect, showing that pretreatment with IFN-gamma strongly suppressed IL-5-induced eosinophil shape change, and cycloheximide (CHX) abrogated the suppression by IFN-gamma, suggesting that new protein synthesis is required for the inhibitory effect by this cytokine. Cycloheximide 160-163 interferon gamma Homo sapiens 24-33 15683856-3 2005 Since cyclic adenosine monophosphate (cAMP) production is stimulated by some antidepressants, and since cAMP inhibits IFN-gamma and stimulates IL-10 production, we postulate that the negative immunoregulatory effects of antidepressants result from their effects on the cAMP-dependent protein kinase A (PKA) pathway. Cyclic AMP 104-108 interferon gamma Homo sapiens 118-127 15735428-11 2005 In rectal biopsy explants, inflamed, noninflamed CD, and control tissue responded to stimulation with Io + PMA (P < 0.05) with increased IFN-gamma and TNF-alpha (P < 0.05). io + pma 102-110 interferon gamma Homo sapiens 140-149 15683856-6 2005 Fluoxetine, 10(-6) and 10(-5) M, significantly reduced the production of IFN-gamma and TNF-alpha, and significantly decreased the IFN-gamma/IL-10 production ratio. Fluoxetine 0-10 interferon gamma Homo sapiens 73-82 15683856-6 2005 Fluoxetine, 10(-6) and 10(-5) M, significantly reduced the production of IFN-gamma and TNF-alpha, and significantly decreased the IFN-gamma/IL-10 production ratio. Fluoxetine 0-10 interferon gamma Homo sapiens 130-139 15683856-9 2005 It is concluded that the suppressant effect of fluoxetine on the IFN-gamma/IL-10 production ratio is probably not related to the induction of the cAMP-dependent PKA pathway, whereas the suppressant effect on TNF-alpha may be related to the induction of PKA. Fluoxetine 47-57 interferon gamma Homo sapiens 65-74 15683856-10 2005 The obtained results suggest that increased activation of the PKA-dependent pathway may constitute an important molecular basis for some (suppression of TNF-alpha production), but not all (suppression of IFN-gamma production), negative immunoregulatory effects of fluoxetine. Fluoxetine 264-274 interferon gamma Homo sapiens 204-213 15799959-5 2005 The authors established a screening protocol using human peripheral blood mononuclear cells (PBMCs) and identified the hydrazino anthranilate compound 1 as a potent inhibitor of IL-12/IL-18-mediated IFN-gamma secretion from CD3(+) cells with an IC(50) around 200 nM. hydrazino anthranilate 119-141 interferon gamma Homo sapiens 199-208 15659543-4 2005 RESULTS: Stimulation with the cytokines interleukin-1beta(IL-1beta)/interferon-gamma (IFN-gamma) increased NO up to 3.3-fold and moxifloxacin inhibited this up to 68% (P < 0.05). Moxifloxacin 129-141 interferon gamma Homo sapiens 68-84 15659543-4 2005 RESULTS: Stimulation with the cytokines interleukin-1beta(IL-1beta)/interferon-gamma (IFN-gamma) increased NO up to 3.3-fold and moxifloxacin inhibited this up to 68% (P < 0.05). Moxifloxacin 129-141 interferon gamma Homo sapiens 86-95 15799959-9 2005 Thus, the IL-12/IL-18-mediated proliferation and IFN-gamma secretion are very sensitive to intracellular iron concentration. Iron 105-109 interferon gamma Homo sapiens 49-58 15618295-2 2005 Pravastatin and fluvastatin also induced the production of IL-18, tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in human peripheral blood mononuclear cells (PBMC) in contrast to LFA703. Pravastatin 0-11 interferon gamma Homo sapiens 128-137 15618295-2 2005 Pravastatin and fluvastatin also induced the production of IL-18, tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in human peripheral blood mononuclear cells (PBMC) in contrast to LFA703. Fluvastatin 16-27 interferon gamma Homo sapiens 110-126 15618295-2 2005 Pravastatin and fluvastatin also induced the production of IL-18, tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in human peripheral blood mononuclear cells (PBMC) in contrast to LFA703. Pravastatin 0-11 interferon gamma Homo sapiens 110-126 15618295-2 2005 Pravastatin and fluvastatin also induced the production of IL-18, tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in human peripheral blood mononuclear cells (PBMC) in contrast to LFA703. Fluvastatin 16-27 interferon gamma Homo sapiens 128-137 15618295-6 2005 In the presence of higher concentrations (5, 10, and 100 ng/ml) of IL-18, pravastatin, fluvastatin, and LFA703 similarly inhibited the expression of ICAM-1 and CD40 as well as the production of IL-12, TNF-alpha, and IFN-gamma in PBMC. Pravastatin 74-85 interferon gamma Homo sapiens 216-225 15618295-6 2005 In the presence of higher concentrations (5, 10, and 100 ng/ml) of IL-18, pravastatin, fluvastatin, and LFA703 similarly inhibited the expression of ICAM-1 and CD40 as well as the production of IL-12, TNF-alpha, and IFN-gamma in PBMC. Fluvastatin 87-98 interferon gamma Homo sapiens 216-225 15618295-6 2005 In the presence of higher concentrations (5, 10, and 100 ng/ml) of IL-18, pravastatin, fluvastatin, and LFA703 similarly inhibited the expression of ICAM-1 and CD40 as well as the production of IL-12, TNF-alpha, and IFN-gamma in PBMC. LFA703 104-110 interferon gamma Homo sapiens 216-225 15715651-0 2005 Protective autoimmunity: interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators. Glutamic Acid 70-79 interferon gamma Homo sapiens 25-41 15715651-9 2005 Up-regulation of glutamate uptake induced by IFN-gamma activation was not accompanied by the acute inflammatory response seen in LPS-activated cultures. Glutamic Acid 17-26 interferon gamma Homo sapiens 45-54 15734263-11 2005 Exposure to lipopolysaccharide (LPS) and IFN-gamma significant increased endogenous nitrite production. Nitrites 84-91 interferon gamma Homo sapiens 41-50 15734252-8 2005 Only osteolytic THA subjects demonstrated increased cytokine responses with >two-fold (p<0.05) increases in soluble interferon-gamma (IFN-gamma) and interleukin-2 (IL-2) levels in response to Cr challenge. Chromium 198-200 interferon gamma Homo sapiens 122-138 15734263-12 2005 In parallel with the increase in endogenous NO, administration of LPS and IFN-gamma suppressed cell viability, mitochondrial membrane potential, and ATP synthesis. Adenosine Triphosphate 149-152 interferon gamma Homo sapiens 74-83 15563545-9 2005 Interferon-gamma/IL-1beta pretreatment sensitizes human thyroid cells to Fas-mediated apoptosis in a complex manner that overcomes this blockade through increased expression of cell surface Fas receptor, increases in proapoptotic molecules that result in mitochondrial activation, and late caspase cleavage. ammonium ferrous sulfate 73-76 interferon gamma Homo sapiens 0-16 15748169-7 2005 Treatment of neurons with H(2)O(2) and rotenone also inhibited interferon-gamma-mediated activation of Jak/STAT1. Hydrogen Peroxide 26-34 interferon gamma Homo sapiens 63-79 15748169-7 2005 Treatment of neurons with H(2)O(2) and rotenone also inhibited interferon-gamma-mediated activation of Jak/STAT1. Rotenone 39-47 interferon gamma Homo sapiens 63-79 15718917-4 2005 Tryptophan is enzymatically degraded by indoleamine 2,3-dioxygenase (IDO), whose activity is solely dependent on expression of interferon-gamma (IFN-gamma). Tryptophan 0-10 interferon gamma Homo sapiens 127-143 15722411-3 2005 One analogue containing a diunsaturated C20 fatty acid (C20:2) potently induced a T helper type 2-biased cytokine response, with diminished IFN-gamma production and reduced Valpha14i NKT cell expansion. c20 fatty acid 40-54 interferon gamma Homo sapiens 140-149 15718917-4 2005 Tryptophan is enzymatically degraded by indoleamine 2,3-dioxygenase (IDO), whose activity is solely dependent on expression of interferon-gamma (IFN-gamma). Tryptophan 0-10 interferon gamma Homo sapiens 145-154 15499631-2 2005 This study aims to test the hypothesis that CA-dinucleotide repeat polymorphism in the first intron of the interferon-gamma (IFN-gamma) gene is associated with HPV-initiated cervical carcinogenesis. ca-dinucleotide 44-59 interferon gamma Homo sapiens 107-123 15499631-2 2005 This study aims to test the hypothesis that CA-dinucleotide repeat polymorphism in the first intron of the interferon-gamma (IFN-gamma) gene is associated with HPV-initiated cervical carcinogenesis. ca-dinucleotide 44-59 interferon gamma Homo sapiens 125-134 15466932-1 2005 Indoleamine-2,3-dioxygenase (IDO) and tryptophanyl-tRNA-synthetase (TTS) are interferon-gamma (IFN-gamma)-inducible enzymes that are responsible for tryptophan degradation and for its use in protein synthesis, respectively. Tryptophan 38-48 interferon gamma Homo sapiens 77-93 15842854-8 2005 Dexamethasone significantly inhibited the levels of IFN-gamma and IL-4 (P < 0.01). Dexamethasone 0-13 interferon gamma Homo sapiens 52-61 15466932-1 2005 Indoleamine-2,3-dioxygenase (IDO) and tryptophanyl-tRNA-synthetase (TTS) are interferon-gamma (IFN-gamma)-inducible enzymes that are responsible for tryptophan degradation and for its use in protein synthesis, respectively. Tryptophan 38-48 interferon gamma Homo sapiens 95-104 15699178-6 2005 The suppressive effect on IFN-gamma mRNA expression was more potent than that of DEX and comparable at 30 mug/ml with 10(-7) M CyA. Dexamethasone 81-84 interferon gamma Homo sapiens 26-35 15498860-5 2005 In examining the relationship between genotype and cytolytic T-lymphocyte (CTL) function, transforming growth factor beta (TGF-beta) inhibited restimulation of CTLs in PBLs with adenosine at IFNG base + 874, but not in PBLs homozygous for thymidine. Adenosine 178-187 interferon gamma Homo sapiens 191-195 15699178-7 2005 The suppressive effect on IFN-gamma production was also more potent than that of either DEX or CyA. Dexamethasone 88-91 interferon gamma Homo sapiens 26-35 15699178-9 2005 Finally, by using a thiol antioxidant, N-acetyl cysteine, we found that the suppression of IFN-gamma production by DEP-treated T cells was mediated by oxidative stress. Sulfhydryl Compounds 20-25 interferon gamma Homo sapiens 91-100 15699178-9 2005 Finally, by using a thiol antioxidant, N-acetyl cysteine, we found that the suppression of IFN-gamma production by DEP-treated T cells was mediated by oxidative stress. Acetylcysteine 39-56 interferon gamma Homo sapiens 91-100 15629451-10 2005 IL-1beta plus IFN-gamma-induced synergistic production of HGF was potently inhibited by treatment of cells with the extracellular signal-regulated kinase (ERK) kinase inhibitor PD98059 and the p38 inhibitor SB203580 but not by the c-Jun N-terminal kinase (JNK) inhibitor SP600125. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 177-184 interferon gamma Homo sapiens 14-23 15550390-5 2005 Pretreatment of cells with 500 units/ml IFN-gamma for 12 h inhibited an adenosine-induced short circuit current (Isc) without affecting the transepithelial resistance. Adenosine 72-81 interferon gamma Homo sapiens 40-49 15550390-7 2005 Interestingly, IFN-gamma inhibited cAMP levels as well as its downstream signaling pathway as shown by the inhibition of adenosine-induced phosphorylation of cAMP response element-binding protein and protein kinase A activity. Cyclic AMP 35-39 interferon gamma Homo sapiens 15-24 15550390-7 2005 Interestingly, IFN-gamma inhibited cAMP levels as well as its downstream signaling pathway as shown by the inhibition of adenosine-induced phosphorylation of cAMP response element-binding protein and protein kinase A activity. Adenosine 121-130 interferon gamma Homo sapiens 15-24 15550390-7 2005 Interestingly, IFN-gamma inhibited cAMP levels as well as its downstream signaling pathway as shown by the inhibition of adenosine-induced phosphorylation of cAMP response element-binding protein and protein kinase A activity. Cyclic AMP 158-162 interferon gamma Homo sapiens 15-24 15550390-8 2005 Similar studies with forskolin, a direct activator of adenylate cyclase, also demonstrated inhibition of cAMP and its downstream response by IFN-gamma. Colforsin 21-30 interferon gamma Homo sapiens 141-150 15550390-8 2005 Similar studies with forskolin, a direct activator of adenylate cyclase, also demonstrated inhibition of cAMP and its downstream response by IFN-gamma. Cyclic AMP 105-109 interferon gamma Homo sapiens 141-150 15550390-11 2005 In conclusion, we demonstrate that IFN-gamma down-regulates adenosine-mediated signaling possibly through the direct inhibition of adenylate cyclase expression. Adenosine 60-69 interferon gamma Homo sapiens 35-44 15550390-12 2005 We propose that IFN-gamma may acutely affect global cAMP-mediated responses in the intestinal epithelia, thereby decreasing secretory responses, which may consequently aggravate inflammatory processes. Cyclic AMP 52-56 interferon gamma Homo sapiens 16-25 15680316-4 2005 Study for cytokine production revealed that cholesterol decreased latex-induced production of IFN-gamma and IL-12, while it increased latex-induced production of IL-4, IL-10 and IL-13. Cholesterol 44-55 interferon gamma Homo sapiens 94-103 15680316-4 2005 Study for cytokine production revealed that cholesterol decreased latex-induced production of IFN-gamma and IL-12, while it increased latex-induced production of IL-4, IL-10 and IL-13. Latex 66-71 interferon gamma Homo sapiens 94-103 15629451-10 2005 IL-1beta plus IFN-gamma-induced synergistic production of HGF was potently inhibited by treatment of cells with the extracellular signal-regulated kinase (ERK) kinase inhibitor PD98059 and the p38 inhibitor SB203580 but not by the c-Jun N-terminal kinase (JNK) inhibitor SP600125. SB 203580 207-215 interferon gamma Homo sapiens 14-23 15629451-10 2005 IL-1beta plus IFN-gamma-induced synergistic production of HGF was potently inhibited by treatment of cells with the extracellular signal-regulated kinase (ERK) kinase inhibitor PD98059 and the p38 inhibitor SB203580 but not by the c-Jun N-terminal kinase (JNK) inhibitor SP600125. pyrazolanthrone 271-279 interferon gamma Homo sapiens 14-23 15663903-5 2005 RESULTS: Triptolide suppressed CD80 and CD86 expressions on IFN-gamma (500 kU/L) and LPS (1 mg/L) activated THP-1 cells at nontoxic dosages of 2.5-0.625 microg/L. triptolide 9-19 interferon gamma Homo sapiens 60-69 15604419-5 2005 Interferon-gamma (IFN-gamma) induced endothelial cell GTPCH I protein and BH4 modestly, whereas high-level induction required combinations of IFN-gamma and tumor necrosis factor-alpha (TNF-alpha). sapropterin 74-77 interferon gamma Homo sapiens 0-27 15604419-5 2005 Interferon-gamma (IFN-gamma) induced endothelial cell GTPCH I protein and BH4 modestly, whereas high-level induction required combinations of IFN-gamma and tumor necrosis factor-alpha (TNF-alpha). sapropterin 74-77 interferon gamma Homo sapiens 18-27 15604419-13 2005 Thus, IFN-gamma and TNF-alpha exert distinct but cooperative roles for BH4 biosynthesis in endothelium that may have important implications for vascular function during vascular inflammation. sapropterin 71-74 interferon gamma Homo sapiens 6-15 15681825-5 2005 Barrier dysfunction was also induced by TNF-alpha addition to IFN-gamma-primed, but not control, Caco-2 monolayers. caco-2 97-103 interferon gamma Homo sapiens 62-71 15684607-8 2005 Conditioned medium from 5-FU-treated but not control Capan-2 cells induced IFN-gamma production by activated T cells in an IL-18-dependent manner. Fluorouracil 24-28 interferon gamma Homo sapiens 75-84 15374815-7 2005 Nitrite production by HT-29 cells was significantly increased (P < 0.01) in cocultures with MMCs stimulated with IFN-gamma and LPS. Nitrites 0-7 interferon gamma Homo sapiens 116-125 15374815-9 2005 Interestingly, stimulation of HT-29 with conditioned media from MMCs pretreated with steroids before stimulation with LPS and IFN-gamma induced a significantly (P < 0.01) lower nitrite production. Nitrites 180-187 interferon gamma Homo sapiens 126-135 15723658-5 2005 After activation with IFN-gamma for 12 h, CBDC exhibited cytotoxicity against HL60 and Jurkat cells, while activation with LPS induced cytotoxicity against Daudi and Jurkat cells. cbdc 42-46 interferon gamma Homo sapiens 22-31 15596057-7 2005 A guanine at +195 residing at the boundary of the X-box and a downstream IFN-gamma-activated sequence (GAS 1; between nucleotides +192 to +200) is occupied in IFN-gamma-treated cells, indicating the interaction of an IFN-gamma-inducible/modified factor to this region. Guanine 2-9 interferon gamma Homo sapiens 73-82 15723658-6 2005 However, both LPS- and IFN-gamma-stimulated CBDC showed no cytotoxic activity against normal CD14-negative cord blood mononuclear cells. cbdc 44-48 interferon gamma Homo sapiens 23-32 15677503-2 2005 Under in vitro conditions, interleukin-1beta (IL-1beta) + gamma-interferon (IFN-gamma) induce nitric oxide (NO) production and apoptosis in rodent and human pancreatic beta-cells. Nitric Oxide 94-106 interferon gamma Homo sapiens 76-85 15528299-4 2005 Hoechst 33342 staining and flow cytometric analysis confirmed the induction of apoptosis in granulosa cells by 100 ng/ml rFasL in the presence of interferon-gamma, which was blocked by the concomitant addition of an NO donor, S-nitroso-N-acetylpenicillamine. bisbenzimide ethoxide trihydrochloride 0-13 interferon gamma Homo sapiens 146-162 15528299-4 2005 Hoechst 33342 staining and flow cytometric analysis confirmed the induction of apoptosis in granulosa cells by 100 ng/ml rFasL in the presence of interferon-gamma, which was blocked by the concomitant addition of an NO donor, S-nitroso-N-acetylpenicillamine. S-Nitroso-N-Acetylpenicillamine 226-257 interferon gamma Homo sapiens 146-162 15596057-7 2005 A guanine at +195 residing at the boundary of the X-box and a downstream IFN-gamma-activated sequence (GAS 1; between nucleotides +192 to +200) is occupied in IFN-gamma-treated cells, indicating the interaction of an IFN-gamma-inducible/modified factor to this region. Guanine 2-9 interferon gamma Homo sapiens 159-168 15596057-7 2005 A guanine at +195 residing at the boundary of the X-box and a downstream IFN-gamma-activated sequence (GAS 1; between nucleotides +192 to +200) is occupied in IFN-gamma-treated cells, indicating the interaction of an IFN-gamma-inducible/modified factor to this region. Guanine 2-9 interferon gamma Homo sapiens 159-168 15652398-6 2005 IFN-gamma-activated astrocytes responded to TLR3 ligand poly (I:C) engagement with IL-6 production, while ligands of other TLRs, like LPS, lipoteichoic acid, peptidoglycan, flagellin, and CpG, had no effect. lipoteichoic acid 139-156 interferon gamma Homo sapiens 0-9 15676206-8 2005 Maturation of moDCs with either PGE2 or PGA2 resulted in enhanced IFN-gamma, TNF-alpha, and IL-5 production and repressed IL-10 production in allogeneic mixed leukocyte cultures. Dinoprostone 32-36 interferon gamma Homo sapiens 66-75 15676206-8 2005 Maturation of moDCs with either PGE2 or PGA2 resulted in enhanced IFN-gamma, TNF-alpha, and IL-5 production and repressed IL-10 production in allogeneic mixed leukocyte cultures. prostaglandin A2 40-44 interferon gamma Homo sapiens 66-75 15322070-7 2005 However, CHO ingestion, which attenuated the exercise-induced stress hormone response compared with placebo (P < 0.05), prevented both the decrease in the number and percentage of IFN-gamma-positive CD4+ and CD8+ T lymphocytes and the suppression of IFN-gamma production from stimulated CD4+ and CD8+ T lymphocytes. CAV protocol 9-12 interferon gamma Homo sapiens 183-192 15322070-7 2005 However, CHO ingestion, which attenuated the exercise-induced stress hormone response compared with placebo (P < 0.05), prevented both the decrease in the number and percentage of IFN-gamma-positive CD4+ and CD8+ T lymphocytes and the suppression of IFN-gamma production from stimulated CD4+ and CD8+ T lymphocytes. CAV protocol 9-12 interferon gamma Homo sapiens 253-262 15695932-0 2005 B cell antigen receptor signaling enhances IFN-gamma-induced Stat1 target gene expression through calcium mobilization and activation of multiple serine kinase pathways. Calcium 98-105 interferon gamma Homo sapiens 43-52 15695932-2 2005 Phosphorylation of serine 727 in the transcription activation domain of Stat1 is induced in response to IFN-gamma for maximal transcription activity. Serine 19-25 interferon gamma Homo sapiens 104-113 15644449-5 2005 More specifically, CD8alpha+ DCs produce IL-12 in response to glycolipid presentation, which stimulates secondary IFN-gamma production by NK cells in different organs. Glycolipids 62-72 interferon gamma Homo sapiens 114-123 15856892-2 2005 The experiments measured the effects of AmB-AG on (1) release of tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), and interferon-gamma (IFN-gamma) from phagocytic cells and (2) cell-mediated immune responses. amb-ag 40-46 interferon gamma Homo sapiens 129-145 15665086-5 2005 The Sphingomonas glycosphingolipids (GSLs) and sulfatide variants were shown to activate human NKT cells as measured by IL-4 and IFN-gamma secretion. Glycosphingolipids 37-41 interferon gamma Homo sapiens 129-138 15665086-5 2005 The Sphingomonas glycosphingolipids (GSLs) and sulfatide variants were shown to activate human NKT cells as measured by IL-4 and IFN-gamma secretion. Sulfoglycosphingolipids 47-56 interferon gamma Homo sapiens 129-138 15620577-5 2005 Luteolin, the deglycosylated derivative of one of the major compositions, luteolin-7-glucoside, exerted inhibitory effects on TNF-alpha, IL-6 and IFN-gamma production in activated human whole blood with estimated IC(50)s of 42.73 microM, 44.86 microM and 3.34 microM, respectively. luteolin-7-glucoside 74-94 interferon gamma Homo sapiens 146-155 16173530-10 2005 Because RAU is probably a Thl-mediated disease with elevated levels of IL-2, IFN-gamma, TNF-alpha and IL-6 in either the patient"s sera or oral lesions and these increased levels of cytokines can be reduced by THL, we suggest that THL may be a potential immunoceutical agent for treatment of RAU. Orlistat 26-29 interferon gamma Homo sapiens 77-86 15634892-5 2005 In addition, in response to poly(I:C), myeloid DC induce NK cells to produce IFN-gamma through a mechanism dependent on both IL-12 secretion and cell contact between NK cells and myeloid DC, but independent of type I IFN. poly 28-32 interferon gamma Homo sapiens 77-86 15522880-3 2005 In this report, we demonstrate that the IL-12-induced CsA-resistant pathway of IFN-gamma production is sensitive to rapamycin. Cyclosporine 54-57 interferon gamma Homo sapiens 79-88 15522880-3 2005 In this report, we demonstrate that the IL-12-induced CsA-resistant pathway of IFN-gamma production is sensitive to rapamycin. Sirolimus 116-125 interferon gamma Homo sapiens 79-88 16207329-2 2005 The effects of 17beta-oestradiol and of testosterone were tested on the cultured human monocytic/macrophage cell line (THP-1) activated with IFN-gamma in order to investigate their role in cell proliferation and apoptosis. Testosterone 40-52 interferon gamma Homo sapiens 141-150 15345584-6 2005 The expression of IFN-gamma mRNA and protein was dose-dependently blocked by SB203580, a specific inhibitor of mitogen-activated protein kinase p38, which also caused a dramatic destabilization of IFN-gamma mRNA. SB 203580 77-85 interferon gamma Homo sapiens 18-27 15345584-6 2005 The expression of IFN-gamma mRNA and protein was dose-dependently blocked by SB203580, a specific inhibitor of mitogen-activated protein kinase p38, which also caused a dramatic destabilization of IFN-gamma mRNA. SB 203580 77-85 interferon gamma Homo sapiens 197-206 15621055-0 2005 Lysophosphatidylcholine posttranscriptionally inhibits interferon-gamma-induced IP-10, Mig and I-Tac expression in endothelial cells. Lysophosphatidylcholines 0-23 interferon gamma Homo sapiens 55-71 16265901-6 2005 In addition, the EM CD8 T cells rapidly release IFN-gamma in response to spz challenge. saperconazole 73-76 interferon gamma Homo sapiens 48-57 15667557-2 2005 METHODS: Double-distilled water and adjuvant were added to the naked pcDNA3.1/IFN-gamma, target vector ASOR-PLL and the ASOR-PLL-pcDNA3.1/IFN-gamma complex to create different conformations; molecules that were transfected into BEL7402 cells and the expression efficiency was determined by measuring the IFN-g concentration in the culture supernatant by ELISA. Water 26-31 interferon gamma Homo sapiens 78-87 15667557-2 2005 METHODS: Double-distilled water and adjuvant were added to the naked pcDNA3.1/IFN-gamma, target vector ASOR-PLL and the ASOR-PLL-pcDNA3.1/IFN-gamma complex to create different conformations; molecules that were transfected into BEL7402 cells and the expression efficiency was determined by measuring the IFN-g concentration in the culture supernatant by ELISA. Water 26-31 interferon gamma Homo sapiens 78-83 15667557-5 2005 When chloroquine was added the supernatant IFN-gamma concentration increased in the liposome group and decreased in the bacilliform/chromatoid conformation group . Chloroquine 5-16 interferon gamma Homo sapiens 43-52 15459112-7 2005 Treatment of human islets with a combination of IL-1beta and IFN-gamma (IL-1beta+IFN-gamma), for 48 h and 5 d, resulted in an increase of NO production and the impairment of glucose-stimulated insulin secretion, respectively. Glucose 174-181 interferon gamma Homo sapiens 61-70 15671558-6 2005 RESULTS: Frequencies of CD3+ T cells producing IFN-gamma (type 1 T cells) in response to phorbol myristate acetate/ionomycin increased (median, 1.8-fold) in patients receiving IL-2 plus HDC but not in those receiving IL-2 alone (P < 0.01 for comparison between arms). Tetradecanoylphorbol Acetate 89-114 interferon gamma Homo sapiens 47-56 15671558-6 2005 RESULTS: Frequencies of CD3+ T cells producing IFN-gamma (type 1 T cells) in response to phorbol myristate acetate/ionomycin increased (median, 1.8-fold) in patients receiving IL-2 plus HDC but not in those receiving IL-2 alone (P < 0.01 for comparison between arms). Ionomycin 115-124 interferon gamma Homo sapiens 47-56 15459112-7 2005 Treatment of human islets with a combination of IL-1beta and IFN-gamma (IL-1beta+IFN-gamma), for 48 h and 5 d, resulted in an increase of NO production and the impairment of glucose-stimulated insulin secretion, respectively. Glucose 174-181 interferon gamma Homo sapiens 72-90 15459112-8 2005 Silymarin prevented IL-1beta+IFN-gamma-induced NO production and beta-cell dysfunction in human islets. Silymarin 0-9 interferon gamma Homo sapiens 20-38 15580653-4 2005 The circulating gag-specific CD8(+) T cells in fresh blood reliably produced IFN-gamma but lacked IL-2 and high perforin levels and failed to expand significantly during culture with mature DC presenting HIV-1 gag peptides. Glycosaminoglycans 16-19 interferon gamma Homo sapiens 77-86 15809211-6 2005 Amongst the hypoxic infants, the number of days of oxygen supplementation correlated positively with early IL-10 levels (p=0.009; r=0.495) and negatively with the IFN-gamma/IL-10 ratio (p=0.007; r=0.495). Oxygen 51-57 interferon gamma Homo sapiens 163-172 15991530-3 2005 MATERIAL & METHODS: The present study is a part of prospective trial on IFNgamma application in the treatment of CIN I/CINII associated with high-risk HPV infection. Adenosine Monophosphate 10-13 interferon gamma Homo sapiens 76-84 15660915-5 2005 TCR-activated primary T cells from healthy donors treated with c-Rel antisense oligonucleotides produced lower levels of IL-2 and IFN-gamma and proliferated less efficiently than the corresponding control T cells. Oligonucleotides 79-95 interferon gamma Homo sapiens 130-139 15496449-5 2005 Interaction of this complex with the HAF1-cis element requires ICSBP tyrosine phosphorylation, which is induced by IFN-gamma stimulation of phagocytic cells. Tyrosine 69-77 interferon gamma Homo sapiens 115-124 15496449-8 2005 HoxA10 tyrosine phosphorylation, which occurs in response to IFN-gamma, decreases HoxA10 DNA binding and therefore repression of CYBB transcription. Tyrosine 7-15 interferon gamma Homo sapiens 61-70 15496449-9 2005 In these studies, we determine Janus tyrosine kinase 2 (JAK2) activation is necessary and sufficient for IFN-gamma-induced CYBB transcription in phagocytic cells and also for ICSBP and HoxA10 tyrosine phosphorylation. Tyrosine 37-45 interferon gamma Homo sapiens 105-114 16433213-2 2005 In vitro immunologic study with basophil activation test and late cellular activation study (CD69 and production of interferon gamma) with chlorothiazide were performed, and no activation was observed. Chlorothiazide 139-153 interferon gamma Homo sapiens 116-132 15611245-5 2005 However, beta-oxa 25:6n-3 and beta-oxa 21:4n-3 displayed lower inhibitory action on IFN-gamma production. beta-oxa 9-17 interferon gamma Homo sapiens 84-93 15496974-6 2005 Thus, we provide evidence that polymorphic IFN-gamma alleles are associated with age at clinical presentation and risk groups such as prednisone response in B-lineage ALL, suggesting distinct effects of IFN-gamma in immunosurveillance and early response to steroid therapy. Prednisone 134-144 interferon gamma Homo sapiens 43-52 15496974-6 2005 Thus, we provide evidence that polymorphic IFN-gamma alleles are associated with age at clinical presentation and risk groups such as prednisone response in B-lineage ALL, suggesting distinct effects of IFN-gamma in immunosurveillance and early response to steroid therapy. Prednisone 134-144 interferon gamma Homo sapiens 203-212 15496974-6 2005 Thus, we provide evidence that polymorphic IFN-gamma alleles are associated with age at clinical presentation and risk groups such as prednisone response in B-lineage ALL, suggesting distinct effects of IFN-gamma in immunosurveillance and early response to steroid therapy. Steroids 257-264 interferon gamma Homo sapiens 43-52 14624357-2 2005 We have found that the IFN-gamma-mediated activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) is, at least in part, responsible for this antimicrobial activity. Tryptophan 60-70 interferon gamma Homo sapiens 23-32 15589048-3 2005 Pretreatment with RU486 blocked morphine-induced increases in IFN-beta, and reversed the suppression of IFN-gamma. Mifepristone 18-23 interferon gamma Homo sapiens 104-113 14624357-11 2005 In contrast, high doses of steroids were able to enhance the IFN-gamma-induced antimicrobial activity. Steroids 27-35 interferon gamma Homo sapiens 61-70 14624357-5 2005 We investigated whether steroids could affect the antimicrobial effect of IFN-gamma-induced IDO activation. Steroids 24-32 interferon gamma Homo sapiens 74-83 14624357-6 2005 We found that hydrocortisone and dexamethasone enhance IFN-gamma-mediated IDO activity in both human astrocytoma cells and native human astrocytes. Hydrocortisone 14-28 interferon gamma Homo sapiens 55-64 14624357-6 2005 We found that hydrocortisone and dexamethasone enhance IFN-gamma-mediated IDO activity in both human astrocytoma cells and native human astrocytes. Dexamethasone 33-46 interferon gamma Homo sapiens 55-64 14624357-8 2005 In addition, we were able to demonstrate that both steroids enhance the IFN-gamma-mediated antimicrobial activity against Toxoplasma gondii, Staphylococcus aureus and group B streptococci. Steroids 51-59 interferon gamma Homo sapiens 72-81 14624357-9 2005 The enhanced antimicrobial effect of IFN-gamma in the presence of glucocorticoids is due to the enhancement of the IDO-mediated tryptophan degradation, demonstrated by the complete abrogation of this antimicrobial effect by tryptophan resupplementation. Tryptophan 128-138 interferon gamma Homo sapiens 37-46 14624357-9 2005 The enhanced antimicrobial effect of IFN-gamma in the presence of glucocorticoids is due to the enhancement of the IDO-mediated tryptophan degradation, demonstrated by the complete abrogation of this antimicrobial effect by tryptophan resupplementation. Tryptophan 224-234 interferon gamma Homo sapiens 37-46 15937357-5 2005 In the current chapter we detail how to use the ELISPOT assay for measuring frequencies of IFN-gamma-producing T-cells in patients with ASNHL. asnhl 136-141 interferon gamma Homo sapiens 91-100 15617735-5 2005 The IC51-mediated induction of cAMP levels, downstream target of A2A and A2B, and inhibition of LPS/IFNgamma-induced expression of iNOS by forskolin, a cAMP activator, document a role for cAMP mediated pathway in anti-inflammatory activity of IC51. Colforsin 139-148 interferon gamma Homo sapiens 100-108 16059651-0 2005 Lack of STAT 1 phosphorylation at TYR 701 by IFNgamma correlates with disease outcome in melanoma patients. Tyrosine 34-37 interferon gamma Homo sapiens 45-53 16059651-10 2005 In conclusion, these results show that the absence of IFNgamma inducibility of STAT 1 phosphorylation at Tyr 701 positively correlates with disease outcome in malignant melanoma patients and may represent new independent prognostic marker. Tyrosine 105-108 interferon gamma Homo sapiens 54-62 15617735-5 2005 The IC51-mediated induction of cAMP levels, downstream target of A2A and A2B, and inhibition of LPS/IFNgamma-induced expression of iNOS by forskolin, a cAMP activator, document a role for cAMP mediated pathway in anti-inflammatory activity of IC51. Cyclic AMP 152-156 interferon gamma Homo sapiens 100-108 16557037-5 2005 The present study showed that the stress-induced and preovulatory levels of prolactin and estradiol, respectively, increased the production of IFN-gamma and IL-12 levels (and IL-10 in the case of estradiol) in PHA + LPS-stimulated whole blood, and inhibited a hydrocortisone (100 nmol/l) suppressive effect on IFN-gamma, IL-12 and IL-10 productions. Hydrocortisone 260-274 interferon gamma Homo sapiens 143-152 15617735-5 2005 The IC51-mediated induction of cAMP levels, downstream target of A2A and A2B, and inhibition of LPS/IFNgamma-induced expression of iNOS by forskolin, a cAMP activator, document a role for cAMP mediated pathway in anti-inflammatory activity of IC51. Cyclic AMP 152-156 interferon gamma Homo sapiens 100-108 15617735-6 2005 Taken together, these studies document that IC51-mediated inhibition of iNOS expression is through activation of adenosine receptors, which activates A2A and A2B resulting in increased cAMP levels following LPS/IFNgamma stimulation. Cyclic AMP 185-189 interferon gamma Homo sapiens 211-219 15608502-6 2005 Acitretin as an established antipsoriatic drug and the tyrosine kinase inhibitor imatinib decreased, whereas hydrocortisone as well as dexamethasone increased the IFN-gamma-induced K17 overexpression. Hydrocortisone 109-123 interferon gamma Homo sapiens 163-172 16463708-1 2005 Neopterin is a low-molecular mass substance synthesized from guanosine triphosphate (GTP) in monocytes/macrophages due to IFNgamma stimulation. Neopterin 0-9 interferon gamma Homo sapiens 122-130 16463708-1 2005 Neopterin is a low-molecular mass substance synthesized from guanosine triphosphate (GTP) in monocytes/macrophages due to IFNgamma stimulation. Guanosine Triphosphate 61-83 interferon gamma Homo sapiens 122-130 16463708-1 2005 Neopterin is a low-molecular mass substance synthesized from guanosine triphosphate (GTP) in monocytes/macrophages due to IFNgamma stimulation. Guanosine Triphosphate 85-88 interferon gamma Homo sapiens 122-130 15608502-6 2005 Acitretin as an established antipsoriatic drug and the tyrosine kinase inhibitor imatinib decreased, whereas hydrocortisone as well as dexamethasone increased the IFN-gamma-induced K17 overexpression. Dexamethasone 135-148 interferon gamma Homo sapiens 163-172 15702787-1 2005 OBJECTIVE: To investigate the effect of cyclosporine A (CsA) on the trophoblast cell secretion of interleukin-10 (IL-10) and interferon-gamma (IFN-gamma) in early pregnancy. Cyclosporine 56-59 interferon gamma Homo sapiens 125-141 15702787-7 2005 IFN-gamma protein expressed in the trophoblast membrane of cell in the CsA at 4 concentrations were almost the same; there was no significant difference among the 4 CsA concentrations (P>0.05). Cyclosporine 71-74 interferon gamma Homo sapiens 0-9 19284357-7 2005 RESULTS: Iron overload leads to inhibition of IFN-gamma, TNF-alpha, IL-12, and nitric oxide formation as well as impairment of macrophage, neutrophil, and T-cell function. Iron 9-13 interferon gamma Homo sapiens 46-55 15629089-3 2005 Then purified CD8(+) T cells were incubated with digitonin for 15 min followed by FITC-anti-IFN-gamma mAb for 20 min. Fluorescein-5-isothiocyanate 82-86 interferon gamma Homo sapiens 92-101 15629089-7 2005 The IFN-gamma level in single CD8(+) T cell from 2 SAA patients was (151.53+/-28.92)zmol and (223.72+/-45.23)zmol, respectively, and much higher that from normal control (47.47+/-17.97)zmol ( P=0.001). zmol 84-88 interferon gamma Homo sapiens 4-13 15629089-7 2005 The IFN-gamma level in single CD8(+) T cell from 2 SAA patients was (151.53+/-28.92)zmol and (223.72+/-45.23)zmol, respectively, and much higher that from normal control (47.47+/-17.97)zmol ( P=0.001). zmol 109-113 interferon gamma Homo sapiens 4-13 15629089-7 2005 The IFN-gamma level in single CD8(+) T cell from 2 SAA patients was (151.53+/-28.92)zmol and (223.72+/-45.23)zmol, respectively, and much higher that from normal control (47.47+/-17.97)zmol ( P=0.001). zmol 109-113 interferon gamma Homo sapiens 4-13 15844596-10 2005 Furthermore, Genistein abrogated the transient increased roles and partly reversed the longterm inhibitory functions by IFN-gamma (P < 0.05) . Genistein 13-22 interferon gamma Homo sapiens 120-129 15614147-5 2004 IFN-gamma up-regulation correlated with the DSBT effect: it was maximal after day-12 DSBT, intermediate after day-6 DSBT, and absent after day-0 DSBT. dsbt 44-48 interferon gamma Homo sapiens 0-9 15614147-5 2004 IFN-gamma up-regulation correlated with the DSBT effect: it was maximal after day-12 DSBT, intermediate after day-6 DSBT, and absent after day-0 DSBT. dsbt 85-89 interferon gamma Homo sapiens 0-9 15614147-5 2004 IFN-gamma up-regulation correlated with the DSBT effect: it was maximal after day-12 DSBT, intermediate after day-6 DSBT, and absent after day-0 DSBT. dsbt 85-89 interferon gamma Homo sapiens 0-9 15614147-5 2004 IFN-gamma up-regulation correlated with the DSBT effect: it was maximal after day-12 DSBT, intermediate after day-6 DSBT, and absent after day-0 DSBT. dsbt 85-89 interferon gamma Homo sapiens 0-9 15614147-8 2004 CONCLUSIONS: Day 2 intragraft IFN-gamma correlates with the DSBT protective effect. dsbt 60-64 interferon gamma Homo sapiens 30-39 15614147-10 2004 These data indicate that DSBT has a stimulatory and a (thymus-dependent) inhibitory effect on early intragraft IFN-gamma. dsbt 25-29 interferon gamma Homo sapiens 111-120 15471850-4 2004 In this study, we have shown that treatment of rat islets with IL-1beta or human islets with a cytokine mixture containing IL-1beta + IFN-gamma +/- TNF-alpha stimulates COX-2 expression and PGE(2) formation in a time-dependent manner. Prostaglandins E 190-193 interferon gamma Homo sapiens 134-143 16359238-5 2005 L-tryptophan, an inhibitor of IDO, completely blocked the antiviral activity of IFN-gamma against vaccinia virus in 143B cells, an human osteosarcoma cell line, whereas N(G)-methyl-L-arginine, a NOS2 inhibitor, did not. Tryptophan 0-12 interferon gamma Homo sapiens 80-89 17037038-3 2005 By contrast, in carboplatin- cultured MNC from healthy subjects, IL-2 significantly potentiated their toxicity for tumor cells by producing interferon-gamma. Carboplatin 16-27 interferon gamma Homo sapiens 140-156 15541342-6 2004 In the presence of interferon (IFN)-gamma, however, cholera toxin- and 8-bromo-cAMP-induced HGF production was not inhibited by IL-1beta. 8-Bromo Cyclic Adenosine Monophosphate 71-83 interferon gamma Homo sapiens 19-41 15507313-7 2004 Since a similar increase in the degree of the IFN-gamma response to the PRRSV vaccine could be achieved by substituting polyinosinic-polycytidylic acid in lieu of either cytokine, exposure to PRRSV in the presence of a variety of Th 1 polarizing molecules can positively influence the development of the cell-mediated immune response of swine to this pathogen. Poly I-C 120-151 interferon gamma Homo sapiens 46-55 15315972-4 2004 Poly I:C also induces the novel capability of producing CXCL10 chemokine in human NK cells and synergistically enhances interferon-gamma (IFN-gamma) production induced by either adaptive or innate cytokines. Poly I-C 0-8 interferon gamma Homo sapiens 120-136 15315972-4 2004 Poly I:C also induces the novel capability of producing CXCL10 chemokine in human NK cells and synergistically enhances interferon-gamma (IFN-gamma) production induced by either adaptive or innate cytokines. Poly I-C 0-8 interferon gamma Homo sapiens 138-147 15585841-7 2004 Swainsonine, an inhibitor of Golgi alpha-mannosidase II, blocked beta1,6GlcNAc N-glycan expression and caused a similar increase in IFN-gamma production by T cells from humans and mice, but no additional enhancement in Mgat5(-/-) T cells. Swainsonine 0-11 interferon gamma Homo sapiens 132-141 15507314-3 2004 We found that soluble high molecular weight beta-glucan could increase IFNgamma-producing cell frequency in a dose-dependent manner in the enzyme-linked immunospot assay (ELISPOT) in the absence of antigenic restimulation. beta-Glucans 44-55 interferon gamma Homo sapiens 71-79 15507314-5 2004 In PRRSV-specific IFNgamma ELISPOT, soluble beta-glucan elicited increased PRRSV-specific responses at concentrations from 3.2 to 50 microg/ml, but not at 100 microg/ml, whereas insoluble beta-glucan had no effect. beta-Glucans 44-55 interferon gamma Homo sapiens 18-26 15286001-13 2004 Inflammation and fibrotic processes in lung tissue of patients exposed to sulfur mustard may be progressive so IFN-gamma may be a useful drug to these patients" treatment. Mustard Gas 74-88 interferon gamma Homo sapiens 111-120 15321787-3 2004 We investigated FKN expression by human ASMC in response to the proinflammatory cytokines IL-1beta, TNF-alpha, and IFN-gamma, the T helper 2-type cytokines IL-4, IL-10, and IL-13, and the fibrogenic cytokine transforming growth factor (TGF)-beta. asmc 40-44 interferon gamma Homo sapiens 115-124 15321787-10 2004 IFN-gamma- and TNF-alpha-induced JNK phosphorylation remained unaltered in the presence of TGF-beta but was inhibited by dexamethasone, indicating that JNK is not involved in TGF-beta- or dexamethasone-mediated regulation of FKN production. Dexamethasone 121-134 interferon gamma Homo sapiens 0-9 15593217-11 2004 Lipopolysaccharide- or lipoteichoic acid-mediated triggering of PBMCs incubated with IL-12/IL-18 or IFNgamma led to an increased production of both TNFalpha and IL-6, indicating the functionality of TLR-2 and TLR-4. lipoteichoic acid 23-40 interferon gamma Homo sapiens 100-108 15768791-5 2004 TMC were obtained from resected tonsils, and total and HP-specific IgA levels, along with the concentration of TGF-beta, IL-10 and IFN-gamma in the supernatant of stimulated TMC were measured by ELISA. tmc 174-177 interferon gamma Homo sapiens 131-140 15768791-8 2004 We found that IgA-related cytokine (IFN-gamma, IL-10, and TGF-beta) production by unstimulated or stimulated TMC was higher in IgAN patients than CT patients. tmc 109-112 interferon gamma Homo sapiens 36-45 15574787-4 2004 In contrast with the NKT cell agonist alpha-galactosylceramide, which induces both IFN-gamma and IL-4 production by NKT cells, CpG-liposome only induced IFN-gamma production by NKT cells. alpha-galactosylceramide 38-62 interferon gamma Homo sapiens 83-92 15611648-3 2004 Here we demonstrate that the soy isoflavone genistein, a tyrosine kinase inhibitor, rapidly decreased IL-10 secretion followed by upregulation of IFNgamma and inhibition of cell proliferation with pre-dominantly G2 arrest. Isoflavones 33-43 interferon gamma Homo sapiens 146-154 15611648-3 2004 Here we demonstrate that the soy isoflavone genistein, a tyrosine kinase inhibitor, rapidly decreased IL-10 secretion followed by upregulation of IFNgamma and inhibition of cell proliferation with pre-dominantly G2 arrest. Genistein 44-53 interferon gamma Homo sapiens 146-154 15611657-4 2004 Interestingly, while CDIR abrogates the IFN-gamma-modulated sensitization to Fas, it enhances the sensitization to TRAIL. ammonium ferrous sulfate 77-80 interferon gamma Homo sapiens 40-49 15477228-8 2004 Although autologous T cells primed by the ovalbumin (OVA)-pulsed mature DCs produced IFN-gamma, but not IL-4, OVA-pulsed SP600125-treated mature DCs could initiate IL-4 production from autologous T cells. pyrazolanthrone 121-129 interferon gamma Homo sapiens 85-94 15547726-6 2004 IFN-gamma-mediated facilitation of apoptosis was inhibited by the pan-caspase inhibitor zVAD-fmk and the caspase-8 specific inhibitor zIEDT-fmk, indicating an important role of caspase-8 in mediating sensitation by IFN-gamma in neuroblastoma cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 88-96 interferon gamma Homo sapiens 0-9 15547726-6 2004 IFN-gamma-mediated facilitation of apoptosis was inhibited by the pan-caspase inhibitor zVAD-fmk and the caspase-8 specific inhibitor zIEDT-fmk, indicating an important role of caspase-8 in mediating sensitation by IFN-gamma in neuroblastoma cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 88-96 interferon gamma Homo sapiens 215-224 15547726-6 2004 IFN-gamma-mediated facilitation of apoptosis was inhibited by the pan-caspase inhibitor zVAD-fmk and the caspase-8 specific inhibitor zIEDT-fmk, indicating an important role of caspase-8 in mediating sensitation by IFN-gamma in neuroblastoma cells. ziedt-fmk 134-143 interferon gamma Homo sapiens 0-9 15547726-6 2004 IFN-gamma-mediated facilitation of apoptosis was inhibited by the pan-caspase inhibitor zVAD-fmk and the caspase-8 specific inhibitor zIEDT-fmk, indicating an important role of caspase-8 in mediating sensitation by IFN-gamma in neuroblastoma cells. ziedt-fmk 134-143 interferon gamma Homo sapiens 215-224 15547726-7 2004 In three of the cell lines [SK-N-BE(2), SK-N-DZ and IMR-32] caspase-8 expression was induced by IFN-gamma, but the cells were still resistant to TRAIL-mediated apoptosis. sk-n-be 28-35 interferon gamma Homo sapiens 96-105 15547726-7 2004 In three of the cell lines [SK-N-BE(2), SK-N-DZ and IMR-32] caspase-8 expression was induced by IFN-gamma, but the cells were still resistant to TRAIL-mediated apoptosis. sk-n-dz 40-47 interferon gamma Homo sapiens 96-105 15569010-4 2004 In this work we describe the effect that thalidomide had on TNF-alpha sera levels and on IL-4- and IFN gamma (IFNgamma)-producing lymphocytes of actinic prurigo (AP) patients. Thalidomide 41-52 interferon gamma Homo sapiens 99-108 15569010-4 2004 In this work we describe the effect that thalidomide had on TNF-alpha sera levels and on IL-4- and IFN gamma (IFNgamma)-producing lymphocytes of actinic prurigo (AP) patients. Thalidomide 41-52 interferon gamma Homo sapiens 110-118 15541638-13 2004 PBMCs from AD patients taken after the treatment and cultured with DME for 5 days, also showed significantly lower levels of IFNgamma production than those taken before the treatment (p=0.012). dme 67-70 interferon gamma Homo sapiens 125-133 15530883-8 2004 Furthermore, NO donors and 8-Br-cGMP could also reverse the increased permeability of the monolayers induced by IL-1beta, IFN-gamma, and LPS. 8-bromoguanosino-3',5'-cyclic monophosphorothioate 27-36 interferon gamma Homo sapiens 122-131 15599406-3 2004 When PBMCs from fluA-immune adult donors were incubated with fluA, IFN-gamma was produced by both CD56(dim) and CD56(bright) subsets of NK cells, as well as by fluA-specific T cells. flua 16-20 interferon gamma Homo sapiens 67-76 15599406-3 2004 When PBMCs from fluA-immune adult donors were incubated with fluA, IFN-gamma was produced by both CD56(dim) and CD56(bright) subsets of NK cells, as well as by fluA-specific T cells. flua 61-65 interferon gamma Homo sapiens 67-76 15599406-3 2004 When PBMCs from fluA-immune adult donors were incubated with fluA, IFN-gamma was produced by both CD56(dim) and CD56(bright) subsets of NK cells, as well as by fluA-specific T cells. flua 61-65 interferon gamma Homo sapiens 67-76 15599406-4 2004 Purified NK cells did not produce IFN-gamma in response to fluA, while depletion of T lymphocytes reduced to background levels the fluA-induced IFN-gamma production by NK cells, which indicates that T cells are required for the IFN-gamma response of NK cells. flua 131-135 interferon gamma Homo sapiens 144-153 15599406-4 2004 Purified NK cells did not produce IFN-gamma in response to fluA, while depletion of T lymphocytes reduced to background levels the fluA-induced IFN-gamma production by NK cells, which indicates that T cells are required for the IFN-gamma response of NK cells. flua 131-135 interferon gamma Homo sapiens 144-153 15599406-5 2004 The fluA-induced IFN-gamma production of NK cells was suppressed by anti-IL-2 Ab, while recombinant IL-2 replaced the helper function of T cells for IFN-gamma production by NK cells. flua 4-8 interferon gamma Homo sapiens 17-26 15599406-6 2004 This indicates that IL-2 produced by fluA-specific T cells is involved in the T cell-dependent IFN-gamma response of NK cells to fluA. flua 37-41 interferon gamma Homo sapiens 95-104 15599406-6 2004 This indicates that IL-2 produced by fluA-specific T cells is involved in the T cell-dependent IFN-gamma response of NK cells to fluA. flua 129-133 interferon gamma Homo sapiens 95-104 15582138-4 2004 Using intracellular staining and flow cytometry, we assessed the ability of freshly isolated liver T cells from these biopsies to produce IFN-gamma, TNF-alpha, IL-2, IL-4, and IL-10 in response to stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 214-217 interferon gamma Homo sapiens 138-147 15579281-6 2004 Preliminary data in SVG cells suggest a tendency for morphine to have a similar effect on LG101305-exposed SVG cells stimulated with a combination of lipopolysaccharide (LPS) and interferon-gamma, whereas this effect was not induced when these cells were incubated with ciglitazone. Morphine 53-61 interferon gamma Homo sapiens 179-195 15591036-7 2004 Stimulation of cytokines (interleukin-1 beta, tumour necrosis factor-alpha, interferon-gamma) induced iNOS promoter activity in all conditions and this was accompanied by an increase in nitric oxide (NO) production. Nitric Oxide 186-198 interferon gamma Homo sapiens 76-92 15588695-7 2004 When compared to medium control, the flux of FITC-dextran of the IFN-gamma group was significantly decreased in a dose-dependent fashion. fluorescein isothiocyanate dextran 45-57 interferon gamma Homo sapiens 65-74 15390286-0 2004 Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8. ammonium ferrous sulfate 50-53 interferon gamma Homo sapiens 0-16 15390286-9 2004 CONCLUSIONS: IFN-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis through up-regulation of Fas receptor and caspase-8. ammonium ferrous sulfate 56-59 interferon gamma Homo sapiens 13-22 15588695-9 2004 A significant increase in TER and a significant decrease in the flux of dextran suggested that IFN-gamma clearly reduced the permeability of both ions and high molecular weight material through the keratinocyte sheet. Dextrans 72-79 interferon gamma Homo sapiens 95-104 15546498-10 2004 Ex vivo production of parasite-induced IFN-gamma was negatively correlated to plasma Cu levels in LCL (r = -0.57, p = 0.01). Copper 85-87 interferon gamma Homo sapiens 39-48 15546498-11 2004 In vitro, increased Cu levels inhibited IFN-gamma production. Copper 20-22 interferon gamma Homo sapiens 40-49 15546498-17 2004 Environmentally or genetically determined increases in Cu levels might augment susceptibility to infection with intracellular pathogens, by causing a decrease in IFN-gamma production. Copper 55-57 interferon gamma Homo sapiens 162-171 15270718-0 2004 NMR characterization of the interaction between the C-terminal domain of interferon-gamma and heparin-derived oligosaccharides. heparin-derived oligosaccharides 94-126 interferon gamma Homo sapiens 73-89 15265789-3 2004 In PPAR-gamma-null NK cells, 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), a natural PPAR-gamma ligand, reduces IFN-gamma production that can be reversed by MG132 and/or chloroquine, and it inhibits cytolytic activity of NK cells through reduction of both conjugate formation and CD69 expression. prostaglandin j 51-66 interferon gamma Homo sapiens 121-130 15265789-3 2004 In PPAR-gamma-null NK cells, 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), a natural PPAR-gamma ligand, reduces IFN-gamma production that can be reversed by MG132 and/or chloroquine, and it inhibits cytolytic activity of NK cells through reduction of both conjugate formation and CD69 expression. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 166-171 interferon gamma Homo sapiens 121-130 15270718-4 2004 IFNgamma activity is modulated by the binding of its C-terminal domain to HS (heparan sulphate), a glycosaminoglycan found in the extracellular matrix and at the cell surface. Heparitin Sulfate 74-76 interferon gamma Homo sapiens 0-8 15265789-3 2004 In PPAR-gamma-null NK cells, 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), a natural PPAR-gamma ligand, reduces IFN-gamma production that can be reversed by MG132 and/or chloroquine, and it inhibits cytolytic activity of NK cells through reduction of both conjugate formation and CD69 expression. Chloroquine 179-190 interferon gamma Homo sapiens 121-130 15265789-4 2004 In PPARgamma-positive NK cells, PPAR-gamma activation by 15d-PGJ(2) and ciglitazone (a synthetic ligand) leads to reduction in both mRNA and protein levels of IFN-gamma. 15d-pgj 57-64 interferon gamma Homo sapiens 159-168 15270718-4 2004 IFNgamma activity is modulated by the binding of its C-terminal domain to HS (heparan sulphate), a glycosaminoglycan found in the extracellular matrix and at the cell surface. Heparitin Sulfate 78-94 interferon gamma Homo sapiens 0-8 15265789-4 2004 In PPARgamma-positive NK cells, PPAR-gamma activation by 15d-PGJ(2) and ciglitazone (a synthetic ligand) leads to reduction in both mRNA and protein levels of IFN-gamma. ciglitazone 72-83 interferon gamma Homo sapiens 159-168 15270718-5 2004 In the present study, we analysed the interaction of isolated heparin-derived oligosaccharides with the C-terminal peptide of IFNgamma by NMR, in aqueous solution. heparin-derived 62-77 interferon gamma Homo sapiens 126-134 15270718-5 2004 In the present study, we analysed the interaction of isolated heparin-derived oligosaccharides with the C-terminal peptide of IFNgamma by NMR, in aqueous solution. Oligosaccharides 78-94 interferon gamma Homo sapiens 126-134 15548705-13 2004 We conclude that doxorubicin potentiates STAT1 activation in response to IFN-gamma, and that this combination results in enhanced apoptosis in breast cancer cells. Doxorubicin 17-28 interferon gamma Homo sapiens 73-82 15389884-3 2004 Cerivastatin and atorvastatin dose-dependently inhibited in vitro calcification of human vascular smooth muscle cells (HVSMCs) induced by the following inflammatory mediators (IM): interferon-gamma, 1alpha,25-dihydroxyvitamin D3, tumor necrosis factor-alpha, and oncostatin M. cerivastatin 0-12 interferon gamma Homo sapiens 181-257 15389884-3 2004 Cerivastatin and atorvastatin dose-dependently inhibited in vitro calcification of human vascular smooth muscle cells (HVSMCs) induced by the following inflammatory mediators (IM): interferon-gamma, 1alpha,25-dihydroxyvitamin D3, tumor necrosis factor-alpha, and oncostatin M. Atorvastatin 17-29 interferon gamma Homo sapiens 181-257 15528336-8 2004 We also found that SP600125 interferes with their IFN-gamma response but does not block their cytolytic function. pyrazolanthrone 19-27 interferon gamma Homo sapiens 50-59 15528362-9 2004 AG490, a tyrosine kinase inhibitor affecting Jak proteins, inhibits CD2-mediated IFN-gamma mRNA expression, secretion, and nucleoprotein binding to the IFN-gamma STAT5 site in a dose-dependent fashion. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 0-5 interferon gamma Homo sapiens 81-90 15528362-9 2004 AG490, a tyrosine kinase inhibitor affecting Jak proteins, inhibits CD2-mediated IFN-gamma mRNA expression, secretion, and nucleoprotein binding to the IFN-gamma STAT5 site in a dose-dependent fashion. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 0-5 interferon gamma Homo sapiens 152-161 15504415-1 2004 The guanylate-binding proteins (GBPs) form a group of interferon-gamma inducible GTP-binding proteins which belong to the family of dynamin-related proteins. Guanosine Triphosphate 81-84 interferon gamma Homo sapiens 54-70 15519708-4 2004 Co-integrating CpG oligonucleotides into liposomes further increased the number of IFN-gamma-secreting cells by 2-10-fold for most epitopes tested. Oligonucleotides 19-35 interferon gamma Homo sapiens 83-92 15231486-4 2004 IFN-gamma-treated T84 and THP-1 (monocytic cell line) cells displayed STAT1 activation (tyrosine phosphorylation on Western blot analysis, DNA binding on EMSA) and upregulation of interferon response factor-1 mRNA, a STAT1-dependent gene. Tyrosine 88-96 interferon gamma Homo sapiens 0-9 15527765-1 2004 The present study shows that the IFN-gamma-mediated upregulation of secretory phospholipase A2 of group IIA (sPLA2-IIA) in HASMC and HepG2 cells is synergistically increased after simultaneous inhibition of glycogen synthase kinase-3beta (GSK-3beta) by indirubin-3"-monoxime, 5-iodo or AR-A014418. hasmc 123-128 interferon gamma Homo sapiens 33-42 15527765-1 2004 The present study shows that the IFN-gamma-mediated upregulation of secretory phospholipase A2 of group IIA (sPLA2-IIA) in HASMC and HepG2 cells is synergistically increased after simultaneous inhibition of glycogen synthase kinase-3beta (GSK-3beta) by indirubin-3"-monoxime, 5-iodo or AR-A014418. indirubin-3'-monoxime 253-274 interferon gamma Homo sapiens 33-42 15527765-1 2004 The present study shows that the IFN-gamma-mediated upregulation of secretory phospholipase A2 of group IIA (sPLA2-IIA) in HASMC and HepG2 cells is synergistically increased after simultaneous inhibition of glycogen synthase kinase-3beta (GSK-3beta) by indirubin-3"-monoxime, 5-iodo or AR-A014418. iodo 278-282 interferon gamma Homo sapiens 33-42 15527765-1 2004 The present study shows that the IFN-gamma-mediated upregulation of secretory phospholipase A2 of group IIA (sPLA2-IIA) in HASMC and HepG2 cells is synergistically increased after simultaneous inhibition of glycogen synthase kinase-3beta (GSK-3beta) by indirubin-3"-monoxime, 5-iodo or AR-A014418. Argon 286-288 interferon gamma Homo sapiens 33-42 15527765-1 2004 The present study shows that the IFN-gamma-mediated upregulation of secretory phospholipase A2 of group IIA (sPLA2-IIA) in HASMC and HepG2 cells is synergistically increased after simultaneous inhibition of glycogen synthase kinase-3beta (GSK-3beta) by indirubin-3"-monoxime, 5-iodo or AR-A014418. a014418 289-296 interferon gamma Homo sapiens 33-42 15231486-0 2004 Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-gamma but not by IL-4. Polyphenols 10-20 interferon gamma Homo sapiens 100-109 15231486-0 2004 Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-gamma but not by IL-4. epigallocatechin gallate 21-49 interferon gamma Homo sapiens 100-109 15231486-6 2004 Aurintricarboxylic acid also blocked IFN-gamma-induced STAT1 activation, but it did not prevent the increase in epithelial permeability. Aurintricarboxylic Acid 0-23 interferon gamma Homo sapiens 37-46 15231486-8 2004 Thus, as a potential adjunct anti-inflammatory agent, EGCG can block STAT1-dependent events in gut epithelia and monocytes and prevent IFN-gamma-induced increased epithelial permeability. epigallocatechin gallate 54-58 interferon gamma Homo sapiens 135-144 15231486-2 2004 The green tea polyphenol (-)-epigallocatechin gallate (EGCG) has immunosuppressive properties, and we hypothesized that it would ameliorate the increased epithelial permeability induced by IFN-gamma, IL-4, and/or EPEC. polyphenol (-)-epigallocatechin gallate 14-53 interferon gamma Homo sapiens 189-198 15231486-2 2004 The green tea polyphenol (-)-epigallocatechin gallate (EGCG) has immunosuppressive properties, and we hypothesized that it would ameliorate the increased epithelial permeability induced by IFN-gamma, IL-4, and/or EPEC. epigallocatechin gallate 55-59 interferon gamma Homo sapiens 189-198 15162133-6 2004 Vitamin-A deficient infants had significantly reduced ex vivo production of IFN-gamma, but also significantly higher circulating neopterin concentrations. Vitamin A 0-9 interferon gamma Homo sapiens 76-85 15231486-3 2004 EGCG, but not the related epigallocatechin, completely prevented the increase in epithelial (i.e., T84 cell monolayer) permeability caused by IFN-gamma exposure as gauged by transepithelial resistance and horseradish peroxidase flux; EGCG did not alleviate the barrier disruption induced by IL-4 or EPEC. epigallocatechin gallate 0-4 interferon gamma Homo sapiens 142-151 15231486-3 2004 EGCG, but not the related epigallocatechin, completely prevented the increase in epithelial (i.e., T84 cell monolayer) permeability caused by IFN-gamma exposure as gauged by transepithelial resistance and horseradish peroxidase flux; EGCG did not alleviate the barrier disruption induced by IL-4 or EPEC. epigallocatechin gallate 234-238 interferon gamma Homo sapiens 142-151 15308175-2 2004 Critical to the development of this method is the uptake of boron by specific cells of the immune system, namely T cells, without adverse effects on cell function, which may be assessed by the ability of boron-loaded cells to produce IFNgamma, a protein with substantial impact on rejection. Boron 60-65 interferon gamma Homo sapiens 234-242 15308175-2 2004 Critical to the development of this method is the uptake of boron by specific cells of the immune system, namely T cells, without adverse effects on cell function, which may be assessed by the ability of boron-loaded cells to produce IFNgamma, a protein with substantial impact on rejection. Boron 204-209 interferon gamma Homo sapiens 234-242 15284182-7 2004 Following treatment with butyrate, the activation of STAT1 in response to IL-6, but not interferon-gamma, was completely lost. Butyrates 25-33 interferon gamma Homo sapiens 88-104 15511228-11 2004 In further experiments using an antisense oligonucleotide, a specific repression of IRF-1 expression abolished enhancer activity of IFN-gamma for TRAIL-induced apoptosis. Oligonucleotides 42-57 interferon gamma Homo sapiens 132-141 15539157-2 2004 The T-bet-specific AS oligonucleotide and siRNA suppressed T-bet expression, IFNgamma production, and STAT1 levels during antigen-specific T cell differentiation. Oligonucleotides 22-37 interferon gamma Homo sapiens 77-85 15556684-3 2004 Using enzyme-linked immunosorbent assay, we measured unstimulated and concanavalin A/phorbol myristate acetate-stimulated production of interleukin-4 (IL-4), IL-5, IL-10, IL-13 and interferon- gamma (IFN-gamma) by decidual explants from 59 healthy women delivered by unlabored cesarean section and from corresponding CBMCs in 39 of the 59. Tetradecanoylphorbol Acetate 85-110 interferon gamma Homo sapiens 181-198 15556684-3 2004 Using enzyme-linked immunosorbent assay, we measured unstimulated and concanavalin A/phorbol myristate acetate-stimulated production of interleukin-4 (IL-4), IL-5, IL-10, IL-13 and interferon- gamma (IFN-gamma) by decidual explants from 59 healthy women delivered by unlabored cesarean section and from corresponding CBMCs in 39 of the 59. Tetradecanoylphorbol Acetate 85-110 interferon gamma Homo sapiens 200-209 15536428-8 2004 Treatment of keratinocytes with histamine (10 -7 to 10 -4 mol/L) or beta-histine increased the IFN-gamma-induced expression of membrane intercellular adhesion molecule 1 and MHC class I but not MHC class II molecules. Histamine 32-41 interferon gamma Homo sapiens 95-104 15536428-8 2004 Treatment of keratinocytes with histamine (10 -7 to 10 -4 mol/L) or beta-histine increased the IFN-gamma-induced expression of membrane intercellular adhesion molecule 1 and MHC class I but not MHC class II molecules. Betahistine 68-80 interferon gamma Homo sapiens 95-104 15536428-11 2004 Levocetirizine at higher doses also reduced intercellular adhesion molecule 1, CCL5/RANTES, and GM-CSF release induced solely by IFN-gamma. levocetirizine 0-14 interferon gamma Homo sapiens 129-138 15534488-11 2004 GM3/VSSP was shown to induce very strong in vitro IFNgamma secretion in all evaluated melanoma patients. gm3 0-3 interferon gamma Homo sapiens 50-58 15352029-7 2004 Furthermore interferon-gamma suppressed the expression of selenoprotein P mRNA and increased intracellular ROS level, leading to the recovery of the gemcitabine sensitivity in KLM1-R. Reactive Oxygen Species 107-110 interferon gamma Homo sapiens 12-28 15352029-7 2004 Furthermore interferon-gamma suppressed the expression of selenoprotein P mRNA and increased intracellular ROS level, leading to the recovery of the gemcitabine sensitivity in KLM1-R. gemcitabine 149-160 interferon gamma Homo sapiens 12-28 15368520-10 2004 Since recovered CTLs maintained the ability to produce interferon-gamma in response to peptides, these CTLs apparently contribute to the efficacy of lamivudine therapy in patients with hepatitis B. Lamivudine 149-159 interferon gamma Homo sapiens 55-71 15534488-12 2004 Furthermore, in one patient IFNgamma secretion was shown to be GM3-specific. gm3 63-66 interferon gamma Homo sapiens 28-36 15465593-6 2004 However, FS in combination with certain CY doses led to a further significant decrease in host responses compared to either CY or FS treatment alone, including decreased survival rate, increased weight loss, lowered leukocyte numbers, reduced cytokine production in vivo and in vitro, and decreased numbers of cytokine-producing cells (IL-12 and IFNgamma). Cyclophosphamide 40-42 interferon gamma Homo sapiens 346-354 15485493-6 2004 The neurotoxicity resulting from IFN gamma/fA beta treatment was blocked by pretreatment with nitric oxide synthase inhibitor L-N-5-(1-iminoethyl) ornithine hydrochloride (L-NIO), consistent with a role for nitric oxide in the IFN gamma-mediated toxicity mechanism. l-n-5-(1-iminoethyl) ornithine hydrochloride 126-170 interferon gamma Homo sapiens 33-42 15485493-6 2004 The neurotoxicity resulting from IFN gamma/fA beta treatment was blocked by pretreatment with nitric oxide synthase inhibitor L-N-5-(1-iminoethyl) ornithine hydrochloride (L-NIO), consistent with a role for nitric oxide in the IFN gamma-mediated toxicity mechanism. l-n-5-(1-iminoethyl) ornithine hydrochloride 126-170 interferon gamma Homo sapiens 227-236 15485493-6 2004 The neurotoxicity resulting from IFN gamma/fA beta treatment was blocked by pretreatment with nitric oxide synthase inhibitor L-N-5-(1-iminoethyl) ornithine hydrochloride (L-NIO), consistent with a role for nitric oxide in the IFN gamma-mediated toxicity mechanism. N(G)-iminoethylornithine 172-177 interferon gamma Homo sapiens 33-42 15485493-6 2004 The neurotoxicity resulting from IFN gamma/fA beta treatment was blocked by pretreatment with nitric oxide synthase inhibitor L-N-5-(1-iminoethyl) ornithine hydrochloride (L-NIO), consistent with a role for nitric oxide in the IFN gamma-mediated toxicity mechanism. N(G)-iminoethylornithine 172-177 interferon gamma Homo sapiens 227-236 15485493-6 2004 The neurotoxicity resulting from IFN gamma/fA beta treatment was blocked by pretreatment with nitric oxide synthase inhibitor L-N-5-(1-iminoethyl) ornithine hydrochloride (L-NIO), consistent with a role for nitric oxide in the IFN gamma-mediated toxicity mechanism. Nitric Oxide 94-106 interferon gamma Homo sapiens 33-42 15485493-6 2004 The neurotoxicity resulting from IFN gamma/fA beta treatment was blocked by pretreatment with nitric oxide synthase inhibitor L-N-5-(1-iminoethyl) ornithine hydrochloride (L-NIO), consistent with a role for nitric oxide in the IFN gamma-mediated toxicity mechanism. Nitric Oxide 94-106 interferon gamma Homo sapiens 227-236 15590269-4 2004 The decrease in IL-2 and INF-gamma production was observed for both fatty acids, whereas the production of IL-10 was decreased by EPA only. Fatty Acids 68-79 interferon gamma Homo sapiens 25-34 15507847-0 2004 Interferon-gamma impedes reverse cholesterol transport and promotes foam cell transformation in THP-1 human monocytes/macrophages. Cholesterol 33-44 interferon gamma Homo sapiens 0-16 15507847-8 2004 RESULTS: IFN-gamma -treated THP-1 macrophages exhibit increased foam cell transformation compared to untreated cells under cholesterol loading conditions. Cholesterol 123-134 interferon gamma Homo sapiens 9-18 15507847-10 2004 IFN-gamma diminishes cholesterol 27-hydroxylase expression in THP-1, and this IFN-gamma -induced downregulation is prevented by pre-treating the cultured cells with either IFN-gamma neutralizing or IFN-gamma receptor blocking antibody. Cholesterol 21-32 interferon gamma Homo sapiens 0-9 15507847-10 2004 IFN-gamma diminishes cholesterol 27-hydroxylase expression in THP-1, and this IFN-gamma -induced downregulation is prevented by pre-treating the cultured cells with either IFN-gamma neutralizing or IFN-gamma receptor blocking antibody. Cholesterol 21-32 interferon gamma Homo sapiens 78-87 15507847-10 2004 IFN-gamma diminishes cholesterol 27-hydroxylase expression in THP-1, and this IFN-gamma -induced downregulation is prevented by pre-treating the cultured cells with either IFN-gamma neutralizing or IFN-gamma receptor blocking antibody. Cholesterol 21-32 interferon gamma Homo sapiens 78-87 15507847-10 2004 IFN-gamma diminishes cholesterol 27-hydroxylase expression in THP-1, and this IFN-gamma -induced downregulation is prevented by pre-treating the cultured cells with either IFN-gamma neutralizing or IFN-gamma receptor blocking antibody. Cholesterol 21-32 interferon gamma Homo sapiens 78-87 15861321-7 2004 In two recent papers, cholesterol-independent immune effects of statins have been reported, including repressed induction of major histocompatibility complex class II by interferon-gamma, and selective blocking of leukocyte function antigen 1, both of which reduce the activation of T lymphocytes. Cholesterol 22-33 interferon gamma Homo sapiens 170-186 15861321-7 2004 In two recent papers, cholesterol-independent immune effects of statins have been reported, including repressed induction of major histocompatibility complex class II by interferon-gamma, and selective blocking of leukocyte function antigen 1, both of which reduce the activation of T lymphocytes. statins 64-71 interferon gamma Homo sapiens 170-186 15488263-5 2004 RESULTS: BAD patients under chronic lithium treatment had significantly lower numbers of IL-2, IL-6, IL-10 and IFN-gamma secreting cells compared to healthy volunteers. Lithium 36-43 interferon gamma Homo sapiens 111-120 15488155-11 2004 Thus, Gl A+ and AG-EB+ ENC produce IL-1beta, IL-2, IL-4, IL-6, IFN-gamma, TGF-beta1 and TNF-alpha. gamma-Linolenic Acid 6-10 interferon gamma Homo sapiens 63-72 15302890-6 2004 Both IFN-alpha and IFN-gamma induced strong tyrosine phosphorylation of STAT1 in mature but not in immature neutrophils. Tyrosine 44-52 interferon gamma Homo sapiens 19-28 15488263-8 2004 CONCLUSIONS: The significantly lower number of PBLs producing cytokines (IL-2, IL-6, IL-10 and IFN-gamma) in euthymic BAD patients under chronic lithium treatment result from the long-term (over 3 months) lithium administration. Lithium 145-152 interferon gamma Homo sapiens 95-104 15470043-0 2004 Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-gamma- and IL-12-mediated signaling. Oligodeoxyribonucleotides 12-33 interferon gamma Homo sapiens 74-83 15378516-3 2004 Interestingly, lovastatin (one of the most commonly used anticholesterol drugs) treatment of vascular-derived cells has been reported to antagonize activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway, and it is well known that the JAK/STAT pathway plays a central role in interferon-gamma (IFN-gamma)-induced microglial CD40 expression. Lovastatin 15-25 interferon gamma Homo sapiens 331-358 15378516-7 2004 RT-PCR, Western immunoblotting, and flow cytometry data show that lovastatin suppresses IFN-gamma-induced CD40 expression. Lovastatin 66-76 interferon gamma Homo sapiens 88-97 15378516-8 2004 Additionally, lovastatin markedly inhibits IFN-gamma-induced phosphorylation of JAK/STAT1. Lovastatin 14-24 interferon gamma Homo sapiens 43-52 15378516-9 2004 Furthermore, lovastatin is able to suppress microglial tumor necrosis factor-alpha, interleukin (IL)-beta1 and IL-6 production promoted either by IFN-gamma or by Abeta peptide challenge in the presence of CD40 cross-linking. Lovastatin 13-23 interferon gamma Homo sapiens 146-155 15242847-7 2004 Dexamethasone synergistically enhanced TLR2 expression in combination with tumor necrosis factor-alpha and interferon-gamma in terms of both mRNA and protein levels. Dexamethasone 0-13 interferon gamma Homo sapiens 107-123 15456534-10 2004 GF109 abrogated increased proliferation and collagen synthesis by IFN-gamma but it did not affect the inhibitory effects of IFN-gamma. GF 109 0-5 interferon gamma Homo sapiens 66-75 15476228-15 2004 Methotrexate reduced synovial IL-1alpha, IL-1beta, IL-8, IL-10, IL-15, IFNgamma, and TNFalpha mRNA expression, but the effect was significant only for IL-8. Methotrexate 0-12 interferon gamma Homo sapiens 71-79 15627644-11 2004 The production of IL-4 and IFN-gamma was more intense after PMA/ionomycin stimulation than after PMA/ConA stimulation. Ionomycin 64-73 interferon gamma Homo sapiens 27-36 16134003-4 2004 As a result, GD (0.01 mg/mL)-containing medium in stimulated culture supernatants increased IL-2 and IFN-gamma, and decreased IL-4 secretion in MOLT-4. Gadolinium 13-15 interferon gamma Homo sapiens 101-110 15375608-3 2004 Besides its well-known influence on rheologic properties of blood, PTX has also been found to decrease secretion of some cytokines such as IL-12, TNF and IFN-gamma and thus it could exert immunomodulatory activity. Pentoxifylline 67-70 interferon gamma Homo sapiens 154-163 15502923-10 2004 In vitro, treatment with N-acetyl-cysteine enhanced interferon-gamma and interleukin-2 production by CD4-positive splenocytes of the diabetic donor mice. Acetylcysteine 25-42 interferon gamma Homo sapiens 52-68 15448338-9 2004 When IFN-gamma was present during TPA stimulation, the production of infectious virus was reduced by at least a 60 %, and IFN-alpha fully blocked TPA-induced production of infectious virus. Tetradecanoylphorbol Acetate 34-37 interferon gamma Homo sapiens 5-14 15281097-4 2004 SDS-PAGE showed successful conjugation of IFN-gamma with the temperature-sensitive polymer. Sodium Dodecyl Sulfate 0-3 interferon gamma Homo sapiens 42-51 15281097-8 2004 Kynurenine levels, as a measure of IDO bioactivity, were significantly higher in IFN-gamma-treated fibroblasts than in controls (P < 0.001). Kynurenine 0-10 interferon gamma Homo sapiens 81-90 15281097-10 2004 IFN-gamma radiolabeling showed a prolonged retention of IFN-gamma within collagen gel in its polymer-conjugated form, compared to its free form. Polymers 93-100 interferon gamma Homo sapiens 0-9 15281097-10 2004 IFN-gamma radiolabeling showed a prolonged retention of IFN-gamma within collagen gel in its polymer-conjugated form, compared to its free form. Polymers 93-100 interferon gamma Homo sapiens 56-65 15448338-9 2004 When IFN-gamma was present during TPA stimulation, the production of infectious virus was reduced by at least a 60 %, and IFN-alpha fully blocked TPA-induced production of infectious virus. Tetradecanoylphorbol Acetate 146-149 interferon gamma Homo sapiens 5-14 15507763-1 2004 IFN-gamma dependent increase of superoxide production by neutrophils was observed in three patients with Chronic Granulomatous disease from one family. Superoxides 32-42 interferon gamma Homo sapiens 0-9 15342205-2 2004 In this study we found that isoproterenol reduces T-cell proliferation and IFNgamma secretion in PBMCs cultures from healthy controls and IFNbeta-treated but not untreated MS patients. Isoproterenol 28-41 interferon gamma Homo sapiens 75-83 15220936-6 2004 Cycloheximide inhibited IFNgamma release in such optimal conditions, confirming the ability of PMN to synthesize IFNgamma. Cycloheximide 0-13 interferon gamma Homo sapiens 24-32 15220936-6 2004 Cycloheximide inhibited IFNgamma release in such optimal conditions, confirming the ability of PMN to synthesize IFNgamma. Cycloheximide 0-13 interferon gamma Homo sapiens 113-121 15507763-5 2004 The changes of splicing pattern in the transcripts and prolonged effect on superoxide generating ability of patients" neutrophils indicate that IFN-gamma induced an ability to correct abnormal splicing of CYBB gene transcripts in progenitor cells at least in part. Superoxides 75-85 interferon gamma Homo sapiens 144-153 15501300-10 2004 GSDBT significantly increased interferon (IFN)-gamma and interleukin (IL)-2 levels compared with the media control but did not affect IL-4. gsdbt 0-5 interferon gamma Homo sapiens 30-52 15269287-2 2004 Here, we show that prolonged exposure of human monocytic/macrophage THP1 and U937 cells to sulfasalazine, an anti-inflammatory drug and inhibitor of nuclear factor-kappaB (NF-kappaB), resulted in down-regulation of PD-ECGF/TP and IL-8 (mRNA, protein and activity) along with elimination of their induction by tumor necrosis factor-alpha and interferon-gamma. Sulfasalazine 91-104 interferon gamma Homo sapiens 341-357 15295093-7 2004 The acidic oligosaccharide fraction increased the percentage of interferon-gamma producing CD3+CD4+ and CD3+CD8+ cells (p < 0.05) and the IL-13 production in CD3+CD8+ cells (p < 0.05). Oligosaccharides 11-26 interferon gamma Homo sapiens 64-80 15501300-11 2004 GSDBT increased the protein expression of IFN-gamma in MOLT-4 cells. gsdbt 0-5 interferon gamma Homo sapiens 42-51 15554077-0 2004 T helper 1 inhibitor TAK-603 inhibits IFN-gamma and IL-12 production with no effect on IL-18: an observation in sarcoidosis patients. TAK 603 21-28 interferon gamma Homo sapiens 38-47 15554077-14 2004 TAK-603 may ameliorate excess IFN-gamma production and be a therapeutic tool for refractory sarcoidosis. TAK 603 0-7 interferon gamma Homo sapiens 30-39 15554077-3 2004 Thus, the present study was designed to investigate whether TAK-603 ameliorates excess IFN-gamma production in active sarcoidosis. TAK 603 60-67 interferon gamma Homo sapiens 87-96 15554077-4 2004 METHODS: We evaluated inhibitory effects of TAK-603 on IFN-gamma, IL-12 and IL-18 production in stimulated bronchoalveolar lavage (BAL) fluid cells and peripheral blood mononuclear cells (PBMCs) of sarcoidosis patients and healthy subjects. TAK 603 44-51 interferon gamma Homo sapiens 55-64 15554077-5 2004 RESULTS: TAK-603 inhibited IFN-gamma production in stimulated BAL fluid cells and PBMCs of sarcoidosis patients and healthy subjects. TAK 603 9-16 interferon gamma Homo sapiens 27-36 15554077-11 2004 TAK-603 inhibited IFN-gamma production in PHA-stimulated blood T lymphocytes of healthy subjects with stimulation of IL-12 or a combination of IL-12 and IL-18. TAK 603 0-7 interferon gamma Homo sapiens 18-27 15554077-13 2004 CONCLUSIONS: TAK-603 inhibits IFN-gamma production in activated T lymphocytes and IL-12 production in activated monocytes/macrophages independently of increased production of IL-10 and TGF-beta1. TAK 603 13-20 interferon gamma Homo sapiens 30-39 15271977-8 2004 We examined the function of this Stat5-binding motif by transfecting human peripheral blood mononuclear cells with -3.6 kb of IFNG-luciferase constructs and found that phorbol 12-myristate 13-acetate/ionomycin-induced transcription was augmented by IL-2 treatment. Tetradecanoylphorbol Acetate 168-199 interferon gamma Homo sapiens 126-130 15380049-9 2004 GrB secretion was detectable within 10 min of effector-target contact with optimal secretion observed at 3-4 h; in contrast, optimal IFN-gamma secretion was not observed until 24 h. The protein secretion inhibitor, brefeldin A, did not inhibit the release of GrB but did abrogate IFN-gamma production by TALL-104 cells. Brefeldin A 215-226 interferon gamma Homo sapiens 133-142 15448031-7 2004 Likewise, IFN-gamma mRNA and protein production were inhibited when T cells were cocultured with either renal cell carcinoma supernatant-derived gangliosides or a commercial source of purified GD1a. Gangliosides 145-157 interferon gamma Homo sapiens 10-19 15356148-0 2004 Characterization of a dipeptide motif regulating IFN-gamma receptor 2 plasma membrane accumulation and IFN-gamma responsiveness. Dipeptides 22-31 interferon gamma Homo sapiens 49-58 15448031-9 2004 CONCLUSIONS: We propose that renal cell carcinoma-derived tumor products such as gangliosides can induce a type 2 bias in antitumor immunity by initiating apoptosis in the IFN-gamma-producing type 1 effector cells. Gangliosides 81-93 interferon gamma Homo sapiens 172-181 15498318-0 2004 [Ciclosporin down-regulates interferon-gamma gene transcription via its inhibition of nuclear factor kappaB activity after liver transplantation]. Cyclosporine 1-12 interferon gamma Homo sapiens 28-44 15498318-11 2004 CsA down-regulates NF-kappaB activity and further inhibit IFN-gamma gene transcription. Cyclosporine 0-3 interferon gamma Homo sapiens 58-67 15384374-0 2004 [Spironolactone inhibits production of proinflammatory cytokines, including tumor necrosis factor-alpha and interferon-gamma and has potential effect in the treatment of arthritis]. Spironolactone 1-15 interferon gamma Homo sapiens 108-124 15115713-7 2004 RESULTS: Mean (SEM) serum levels of IFNgamma were significantly reduced after leflunomide treatment (baseline 43 (10) pg/ml; 1 year 29 (7) (p = 0.015), but there was no change in IL6 levels (baseline 158 (41), 1 year 151 (48)). Leflunomide 78-89 interferon gamma Homo sapiens 36-44 15273711-6 2004 Parameters for detection of a GvMC effect included flow cytometrical analysis of mast cell (MC) populations in peripheral blood and BM, BM smear and histology, chimerism analysis of flow cytometrically sorted BM CD117+/CD34- MC and testing for anti-mast cell reactivity of donor lymphocytes by interferon (IFN)-gamma ELISPOT. gvmc 30-34 interferon gamma Homo sapiens 294-316 15327519-2 2004 Normal subjects homozygous for 12 (CA) repeats of polymorphism variable number of dinucleotide (CA) repeat (VNDR) in position 1349 of the IFN-gamma gene (IFNG) were shown to overproduce IFN-gammain vitro. Dinucleoside Phosphates 82-94 interferon gamma Homo sapiens 138-147 15327519-2 2004 Normal subjects homozygous for 12 (CA) repeats of polymorphism variable number of dinucleotide (CA) repeat (VNDR) in position 1349 of the IFN-gamma gene (IFNG) were shown to overproduce IFN-gammain vitro. Dinucleoside Phosphates 82-94 interferon gamma Homo sapiens 154-158 15115713-8 2004 Both IFNgamma and IL6 levels were significantly reduced after methotrexate treatment. Methotrexate 62-74 interferon gamma Homo sapiens 5-13 15115713-11 2004 CONCLUSION: The differential effect on IFNgamma and IL6 production supports the hypothesis that activated T cells are preferentially inhibited by leflunomide. Leflunomide 146-157 interferon gamma Homo sapiens 39-47 15342418-1 2004 We have demonstrated previously that interferon (IFN)-gamma sensitizes human colon carcinoma cell lines to the cytotoxic effects of 5-fluorouracil combined with leucovorin and to the thymidylate synthase inhibitor, ZD9331, dependent on thymineless stress-induced DNA damage, independent of p53. Fluorouracil 132-146 interferon gamma Homo sapiens 37-59 15342370-2 2004 We show that IFN-alpha and polyinosinic:polycytidylic acid (p-I:C) synergize with the "classical" type-1-polarizing cytokine cocktail [tumor necrosis factor alpha (TNFalpha)/IL-1beta/IFNgamma], allowing for serum-free generation of fully mature type-1-polarized DCs (DC1). Poly C 40-58 interferon gamma Homo sapiens 183-191 15342418-1 2004 We have demonstrated previously that interferon (IFN)-gamma sensitizes human colon carcinoma cell lines to the cytotoxic effects of 5-fluorouracil combined with leucovorin and to the thymidylate synthase inhibitor, ZD9331, dependent on thymineless stress-induced DNA damage, independent of p53. Leucovorin 161-171 interferon gamma Homo sapiens 37-59 15342418-1 2004 We have demonstrated previously that interferon (IFN)-gamma sensitizes human colon carcinoma cell lines to the cytotoxic effects of 5-fluorouracil combined with leucovorin and to the thymidylate synthase inhibitor, ZD9331, dependent on thymineless stress-induced DNA damage, independent of p53. ZD 9331 215-221 interferon gamma Homo sapiens 37-59 15322157-6 2004 DCs exposed to PS had diminished capacity to stimulate allogeneic T cell proliferation and to activate IFN-gamma-producing CD4(+) T cells. Phosphatidylserines 15-17 interferon gamma Homo sapiens 103-112 15215891-2 2004 A dinucleotide polymorphism consisting of a variable number of CA repeats related with IFNgamma production levels, has been reported on the first intron of the IFNgamma gene. Dinucleoside Phosphates 2-14 interferon gamma Homo sapiens 87-95 15215891-2 2004 A dinucleotide polymorphism consisting of a variable number of CA repeats related with IFNgamma production levels, has been reported on the first intron of the IFNgamma gene. Dinucleoside Phosphates 2-14 interferon gamma Homo sapiens 160-168 15322204-7 2004 Naive CD4(+) T cells primed with alcohol-treated DCs showed decreased IFN-gamma production that was restored by exogenous IL-12, indicating inhibition of Th1 responses. Alcohols 33-40 interferon gamma Homo sapiens 70-79 15350507-6 2004 Median frequencies of IFNgamma+ cells obtained after activation by PMA-ionomycin, PHA or SEA-B were 29.3%, 20.0% and 6.8% for CD4+ cells, and 67.8%, 20.6% and 6.8% for CD8+ cells. Tetradecanoylphorbol Acetate 67-70 interferon gamma Homo sapiens 22-30 15350507-6 2004 Median frequencies of IFNgamma+ cells obtained after activation by PMA-ionomycin, PHA or SEA-B were 29.3%, 20.0% and 6.8% for CD4+ cells, and 67.8%, 20.6% and 6.8% for CD8+ cells. Ionomycin 71-80 interferon gamma Homo sapiens 22-30 15130941-6 2004 Amphoterin was secreted from phorbol ester and interferon-gamma (IFN-gamma)-activated macrophages, and the secretion was inhibited by blocking the adenosine 5"-triphosphate (ATP)-binding cassette transporter-1, a member of the multidrug resistance protein family. Adenosine Triphosphate 147-172 interferon gamma Homo sapiens 65-74 15465113-10 2004 On the other hand, we found significant negative correlations between ADIOL concentrations and production levels of IFN-gamma (P < 0.05) or IL-4 (P < 0.05). Androstenediol 70-75 interferon gamma Homo sapiens 116-125 15358187-1 2004 By in vitro studies 7,8-dihydroneopterin, which is secreted by macrophages stimulated by interferon-gamma, was reported to be a radical scavenger as well as a prooxidative agent depending on the experimental settings. 7,8-dihydroneopterin 20-40 interferon gamma Homo sapiens 89-105 15130941-6 2004 Amphoterin was secreted from phorbol ester and interferon-gamma (IFN-gamma)-activated macrophages, and the secretion was inhibited by blocking the adenosine 5"-triphosphate (ATP)-binding cassette transporter-1, a member of the multidrug resistance protein family. Adenosine Triphosphate 174-177 interferon gamma Homo sapiens 65-74 15261558-4 2004 Relevant immunomodulatory mechanisms act both on T- and B-cell function, and mitoxantrone has selective immune effects in MS by decreasing levels of TNF-alpha, IL-2, IL-2R-beta1, IL-10 and IFN-gamma. Mitoxantrone 77-89 interferon gamma Homo sapiens 189-198 15276069-5 2004 Antigen-specific IFN-gamma production was reduced more effectively by flavones than T-cell proliferation, suggesting that the intracellular pathway for IFN-gamma production in T cells is particularly sensitive to flavone inhibition. Flavones 70-78 interferon gamma Homo sapiens 17-26 15276069-5 2004 Antigen-specific IFN-gamma production was reduced more effectively by flavones than T-cell proliferation, suggesting that the intracellular pathway for IFN-gamma production in T cells is particularly sensitive to flavone inhibition. Flavones 70-78 interferon gamma Homo sapiens 152-161 15276069-5 2004 Antigen-specific IFN-gamma production was reduced more effectively by flavones than T-cell proliferation, suggesting that the intracellular pathway for IFN-gamma production in T cells is particularly sensitive to flavone inhibition. flavone 70-77 interferon gamma Homo sapiens 17-26 15276069-5 2004 Antigen-specific IFN-gamma production was reduced more effectively by flavones than T-cell proliferation, suggesting that the intracellular pathway for IFN-gamma production in T cells is particularly sensitive to flavone inhibition. flavone 70-77 interferon gamma Homo sapiens 152-161 15301717-0 2004 [Enhancement effect of interferon gamma on the sensitivity of RT4 bladder cancer cells to 5"-deoxy-5-fluorouridine,and 5-fluorouracil through up-regulation of PD-ECGF/TP]. doxifluridine 90-114 interferon gamma Homo sapiens 23-39 15318170-6 2004 Closer view at the expression profile of NaB-treated cells revealed the downregulation of a total of 16 genes associated with cytokine signaling, in particular, interferon gamma (IFNgamma) pathway. nab 41-44 interferon gamma Homo sapiens 179-187 15318945-3 2004 METHODS: Cell cultures from two human osteosarcoma cell lines, OHS and its anti-S100A4 ribozyme transfected counterpart II-11b, was treated with IFN-gamma and recombinant S100A4 in order to study the sensitizing effects of extracellular S100A4 on IFN-gamma mediated apoptosis. hydroxide ion 63-66 interferon gamma Homo sapiens 145-154 15318945-5 2004 RESULTS: In the present work, we found that the S100A4-expressing human osteosarcoma cell line OHS was more sensitive to IFN-gamma-mediated apoptosis than the II-11b cells. hydroxide ion 95-98 interferon gamma Homo sapiens 121-130 15318945-7 2004 The S100A4/IFN-gamma-mediated induction of apoptosis was shown to be independent of caspase activation, but dependent on the formation of reactive oxygen species. Reactive Oxygen Species 138-161 interferon gamma Homo sapiens 11-20 15241475-3 2004 Promoter mapping, chromatin immunoprecipitation and RNA interference reveal that retinoid-induced interferon regulatory factor-1 (IRF-1), a tumor suppressor, is critically required for TRAIL induction by both RA and IFNgamma. Retinoids 81-89 interferon gamma Homo sapiens 216-224 15301717-0 2004 [Enhancement effect of interferon gamma on the sensitivity of RT4 bladder cancer cells to 5"-deoxy-5-fluorouridine,and 5-fluorouracil through up-regulation of PD-ECGF/TP]. Fluorouracil 119-133 interferon gamma Homo sapiens 23-39 15301717-1 2004 BACKGROUND & OBJECTIVE: Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is an essential enzyme in converting 5"-deoxy-5-fluorouridine (5"-DFUR), and 5-fluorouracil (5-FU) to their active metabolites in vivo, and can be up-regulated by some cytokines such as interleukin-1, and interferon gamma (INFgamma). doxifluridine 150-174 interferon gamma Homo sapiens 318-334 15301717-1 2004 BACKGROUND & OBJECTIVE: Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is an essential enzyme in converting 5"-deoxy-5-fluorouridine (5"-DFUR), and 5-fluorouracil (5-FU) to their active metabolites in vivo, and can be up-regulated by some cytokines such as interleukin-1, and interferon gamma (INFgamma). doxifluridine 176-183 interferon gamma Homo sapiens 318-334 15301717-1 2004 BACKGROUND & OBJECTIVE: Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is an essential enzyme in converting 5"-deoxy-5-fluorouridine (5"-DFUR), and 5-fluorouracil (5-FU) to their active metabolites in vivo, and can be up-regulated by some cytokines such as interleukin-1, and interferon gamma (INFgamma). Fluorouracil 190-204 interferon gamma Homo sapiens 318-334 15301717-1 2004 BACKGROUND & OBJECTIVE: Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is an essential enzyme in converting 5"-deoxy-5-fluorouridine (5"-DFUR), and 5-fluorouracil (5-FU) to their active metabolites in vivo, and can be up-regulated by some cytokines such as interleukin-1, and interferon gamma (INFgamma). Fluorouracil 206-210 interferon gamma Homo sapiens 318-334 15197346-0 2004 Differential regulation of the protein tyrosine kinase activity following interleukin-2 (IL-2), interferron gamma (IFN-gamma) and SRBC administration in brain tumor-induced conditions: SRBC acting as a dual potentiator in regulating the cytokine profile. srbc 185-189 interferon gamma Homo sapiens 96-124 15302611-2 2004 Th1-type cytokine interferon-gamma (IFN-gamma) induces neopterin production as well as tryptophan degradation via indoleamine (2,3)-dioxygenase (IDO), and quantification of these biochemical alterations allows one to monitor immune system activation. Neopterin 55-64 interferon gamma Homo sapiens 36-45 15302611-2 2004 Th1-type cytokine interferon-gamma (IFN-gamma) induces neopterin production as well as tryptophan degradation via indoleamine (2,3)-dioxygenase (IDO), and quantification of these biochemical alterations allows one to monitor immune system activation. Tryptophan 87-97 interferon gamma Homo sapiens 36-45 15302611-2 2004 Th1-type cytokine interferon-gamma (IFN-gamma) induces neopterin production as well as tryptophan degradation via indoleamine (2,3)-dioxygenase (IDO), and quantification of these biochemical alterations allows one to monitor immune system activation. indolamine 114-125 interferon gamma Homo sapiens 36-45 15254772-2 2004 Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB, resulted in a significant reduction in the percentage of SEB- and interferon-gamma (IFN-gamma) (produced by SEB) -induced CD80+ monocytes. pyrrolidine dithiocarbamic acid 19-46 interferon gamma Homo sapiens 154-170 15277314-7 2004 Downregulation of protein kinase C (PKC) with phorbol-12,13-dibutyrate (PDBu) prevented the inhibitory effect of IFN-gamma on Na(+)-K(+)-ATPase activity. Phorbol 12,13-Dibutyrate 46-70 interferon gamma Homo sapiens 113-122 15277314-7 2004 Downregulation of protein kinase C (PKC) with phorbol-12,13-dibutyrate (PDBu) prevented the inhibitory effect of IFN-gamma on Na(+)-K(+)-ATPase activity. Phorbol 12,13-Dibutyrate 72-76 interferon gamma Homo sapiens 113-122 15277314-8 2004 Inhibition of Raf-1, mitogen-activated protein kinase kinase (MAPKK/MEK), p38 MAPK and STAT1 with, respectively, GW 5074, PD 98059, SB 203580 and epigallocatechin gallate prevented inhibition of Na(+)-K(+)-ATPase activity by IFN-gamma. glycyltryptophan 113-115 interferon gamma Homo sapiens 225-234 15277314-10 2004 Activation of phospho-STAT1 by IFN-gamma was almost abolished by epigallocatechin gallate and markedly reduced by SB 203580, but insensitive to downregulation of PKC. epigallocatechin gallate 65-89 interferon gamma Homo sapiens 31-40 15277314-10 2004 Activation of phospho-STAT1 by IFN-gamma was almost abolished by epigallocatechin gallate and markedly reduced by SB 203580, but insensitive to downregulation of PKC. SB 203580 114-123 interferon gamma Homo sapiens 31-40 15277314-11 2004 The increase in short circuit current (I(sc)) by 1.0 and 2.5 micrograms ml(-1) amphotericin B was markedly attenuated in IFN-gamma-treated cells. Amphotericin B 79-93 interferon gamma Homo sapiens 121-130 15277314-12 2004 However, the inhibitory effect of PDBu on the amphotericin B-induced increase in I(sc) was of similar magnitude in vehicle- and IFN-gamma-treated cells. Amphotericin B 46-60 interferon gamma Homo sapiens 128-137 15259008-7 2004 NKT cells expressing the Valpha24Vbeta11 TCR, which recognizes CD1d,were virtually absent from the intestine, but colonic cells produced IFN-gamma in response to the NKT cell agonist ligand alpha-galactosylceramide. alpha-galactosylceramide 190-214 interferon gamma Homo sapiens 137-146 15223066-3 2004 A beta treatment of C6 glial cells (together with LPS and IFN-gamma), in addition to inducing iNOS, enhanced the oxidative stress as measured by increased expression of manganese superoxide dismutase and an increase in 2,7"-dichlorofluorescein diacetate fluorescence. diacetyldichlorofluorescein 219-253 interferon gamma Homo sapiens 58-67 15223066-4 2004 We also observed that LPS, IFN-gamma, and A beta(25-35) treatment led to the activation of the sphingomyelin-ceramide (SM-Cer) cascade with an increase in cellular ceramide. Sphingomyelins 95-108 interferon gamma Homo sapiens 27-36 15223066-4 2004 We also observed that LPS, IFN-gamma, and A beta(25-35) treatment led to the activation of the sphingomyelin-ceramide (SM-Cer) cascade with an increase in cellular ceramide. Ceramides 109-117 interferon gamma Homo sapiens 27-36 15223066-4 2004 We also observed that LPS, IFN-gamma, and A beta(25-35) treatment led to the activation of the sphingomyelin-ceramide (SM-Cer) cascade with an increase in cellular ceramide. sm-cer 119-125 interferon gamma Homo sapiens 27-36 15223066-4 2004 We also observed that LPS, IFN-gamma, and A beta(25-35) treatment led to the activation of the sphingomyelin-ceramide (SM-Cer) cascade with an increase in cellular ceramide. Ceramides 164-172 interferon gamma Homo sapiens 27-36 15283848-0 2004 Pseudomonas aeruginosa-induced production of free radicals by IFNgamma plus TNFalpha-activated human endothelial cells: mechanism of host defense or of bacterial pathogenesis? Free Radicals 45-58 interferon gamma Homo sapiens 62-70 15283848-1 2004 We have previously shown that human umbilical vein endothelial cells (HUVEC) can be activated by IFNgamma plus TNFalpha to kill intracellular (IC) Pseudomonas aeruginosa through production of reactive oxygen intermediate, but the cumulative effects of cytokine activation and bacterial infection on host cells has not been extensively addressed. reactive oxygen 192-207 interferon gamma Homo sapiens 97-105 15283853-5 2004 However, hIFN-gamma production in sera of Th2 SCID chimeras treated with the combination therapy of hIL-12 and hsIL-4R was recovered at levels observed in healthy SCID chimeras. hil-12 100-106 interferon gamma Homo sapiens 9-19 15254772-2 2004 Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB, resulted in a significant reduction in the percentage of SEB- and interferon-gamma (IFN-gamma) (produced by SEB) -induced CD80+ monocytes. pyrrolidine dithiocarbamic acid 48-52 interferon gamma Homo sapiens 154-170 15254772-2 2004 Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB, resulted in a significant reduction in the percentage of SEB- and interferon-gamma (IFN-gamma) (produced by SEB) -induced CD80+ monocytes. pyrrolidine dithiocarbamic acid 48-52 interferon gamma Homo sapiens 172-181 15254772-2 2004 Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappaB, resulted in a significant reduction in the percentage of SEB- and interferon-gamma (IFN-gamma) (produced by SEB) -induced CD80+ monocytes. pyrrolidine dithiocarbamic acid 19-46 interferon gamma Homo sapiens 172-181 15345313-3 2004 Continuous expression of Gag and Env proteins was detected in stably transduced BLCL, which induced Gag- or Env-specific T cell responses, as measured by both IFNgamma-ELISPOT and chromium release assays, upon in vitro stimulation of PBMC from the SHIV89.6P-infected monkeys. Glycosaminoglycans 25-28 interferon gamma Homo sapiens 159-167 15155784-6 2004 Conversely, IFNgamma and protein inhibitor of activated STAT-y synergistically inhibited PR-dependent transcription, demonstrating that the progesterone and IFNgamma signaling pathways engage in reciprocal transcriptional antagonism in human endometrium. Progesterone 140-152 interferon gamma Homo sapiens 12-20 15284364-12 2004 Preliminary results suggest that once-daily treatment with 400 mg of pentoxifylline orally not only can reduce T-cell expression of TNF-alpha and IFN-gamma, but can also restore the response to erythropoietin and improve haemoglobin levels. Pentoxifylline 69-83 interferon gamma Homo sapiens 146-155 15246629-11 2004 Furthermore, co-inoculation of levamisole increased the production of IFN-gamma by more than 100-fold as compared to that by DNA inoculation formulated in saline. Levamisole 31-41 interferon gamma Homo sapiens 70-79 15274135-4 2004 Here, we show that tyrosyl radicals generated by human neutrophils after activation by phorbol 12-myristate 13-acetate (PMA), interferon-gamma (IFN-gamma) or TNF-alpha could act in an autocrine manner by cross-linking to endogenous proteins. tyrosyl radicals 19-35 interferon gamma Homo sapiens 126-142 15274135-4 2004 Here, we show that tyrosyl radicals generated by human neutrophils after activation by phorbol 12-myristate 13-acetate (PMA), interferon-gamma (IFN-gamma) or TNF-alpha could act in an autocrine manner by cross-linking to endogenous proteins. tyrosyl radicals 19-35 interferon gamma Homo sapiens 144-153 15274135-4 2004 Here, we show that tyrosyl radicals generated by human neutrophils after activation by phorbol 12-myristate 13-acetate (PMA), interferon-gamma (IFN-gamma) or TNF-alpha could act in an autocrine manner by cross-linking to endogenous proteins. Tetradecanoylphorbol Acetate 87-118 interferon gamma Homo sapiens 144-153 15257082-7 2004 In vitro experiments done in parallel showed that long-term culture with interferon-gamma resulted in similar alterations of PMN: loss of chemotactic activity, whereas other functions of PMN, such generation of superoxides and phagocytosis of opsonized bacteria, were preserved or even enhanced. Superoxides 211-222 interferon gamma Homo sapiens 73-89 15276407-1 2004 We evaluated in Mexican children environmentally exposed to arsenic and lead monocyte nitric oxide (NO) and superoxide anion production in response to direct activation with interferon-gamma (IFN-gamma) + lipopolysaccharide (LPS). Arsenic 60-67 interferon gamma Homo sapiens 174-190 15276407-1 2004 We evaluated in Mexican children environmentally exposed to arsenic and lead monocyte nitric oxide (NO) and superoxide anion production in response to direct activation with interferon-gamma (IFN-gamma) + lipopolysaccharide (LPS). Nitric Oxide 86-98 interferon gamma Homo sapiens 174-190 15276407-1 2004 We evaluated in Mexican children environmentally exposed to arsenic and lead monocyte nitric oxide (NO) and superoxide anion production in response to direct activation with interferon-gamma (IFN-gamma) + lipopolysaccharide (LPS). Nitric Oxide 86-98 interferon gamma Homo sapiens 192-201 15276407-1 2004 We evaluated in Mexican children environmentally exposed to arsenic and lead monocyte nitric oxide (NO) and superoxide anion production in response to direct activation with interferon-gamma (IFN-gamma) + lipopolysaccharide (LPS). Superoxides 108-124 interferon gamma Homo sapiens 174-190 15276407-1 2004 We evaluated in Mexican children environmentally exposed to arsenic and lead monocyte nitric oxide (NO) and superoxide anion production in response to direct activation with interferon-gamma (IFN-gamma) + lipopolysaccharide (LPS). Superoxides 108-124 interferon gamma Homo sapiens 192-201 15123634-2 2004 In this study we demonstrated that inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation. Butyrates 86-94 interferon gamma Homo sapiens 159-167 15123634-2 2004 In this study we demonstrated that inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation. trichostatin A 96-110 interferon gamma Homo sapiens 159-167 15123634-2 2004 In this study we demonstrated that inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation. Vorinostat 116-147 interferon gamma Homo sapiens 159-167 15123634-5 2004 Induction of IRF-1 by IFNgamma requires functional STAT1 signaling and was abrogated by butyrate, trichostatin A, suberoylanilide hydroxamic acid, and STAT1 small interfering RNA. Butyrates 88-96 interferon gamma Homo sapiens 22-30 15123634-5 2004 Induction of IRF-1 by IFNgamma requires functional STAT1 signaling and was abrogated by butyrate, trichostatin A, suberoylanilide hydroxamic acid, and STAT1 small interfering RNA. trichostatin A 98-112 interferon gamma Homo sapiens 22-30 15123634-5 2004 Induction of IRF-1 by IFNgamma requires functional STAT1 signaling and was abrogated by butyrate, trichostatin A, suberoylanilide hydroxamic acid, and STAT1 small interfering RNA. Vorinostat 114-145 interferon gamma Homo sapiens 22-30 15505595-8 2004 Ribavirin inhibited TNF-alpha, IFN-gamma, and IL-10 in both PHA and TT-stimulated PBMC at 100 microM (p <0.05). Ribavirin 0-9 interferon gamma Homo sapiens 31-40 15242696-5 2004 The late secretion of IFNgamma at 144 h was also reduced in CIU patients. n-cyclohexyl-n'-(4-iodophenyl)urea 60-63 interferon gamma Homo sapiens 22-30 15213043-7 2004 Selenium supplements augmented the cellular immune response through an increased production of interferon gamma and other cytokines, an earlier peak T cell proliferation, and an increase in T helper cells. Selenium 0-8 interferon gamma Homo sapiens 95-111 15183117-7 2004 Curcumin also inhibited the expression/production of IL-2 and interferon-gamma (IFN-gamma) by splenic T lymphocytes and IL-12 and tumor necrosis factor-alpha (TNF-alpha) by peritoneal macrophages irreversibly. Curcumin 0-8 interferon gamma Homo sapiens 62-78 15183117-7 2004 Curcumin also inhibited the expression/production of IL-2 and interferon-gamma (IFN-gamma) by splenic T lymphocytes and IL-12 and tumor necrosis factor-alpha (TNF-alpha) by peritoneal macrophages irreversibly. Curcumin 0-8 interferon gamma Homo sapiens 80-89 15270870-5 2004 RESULTS: Only CD4+ CLA+ CD45RO+ and not CD8+ T cells proliferate and produce both type-1 (IFN-gamma) and type-2 (IL-5) cytokines in response to nickel. Nickel 144-150 interferon gamma Homo sapiens 82-99 15210574-7 2004 3 Irbesartan inhibited the production of both tumor necrosis factor-alpha and interferon-gamma by activated T-cells, especially at therapeutic concentrations. Irbesartan 2-12 interferon gamma Homo sapiens 78-94 14988219-5 2004 I3C stimulation of the IFNgammaR1 expression suggests that indole treatment should enhance IFNgamma responsiveness in breast cancer cells. indole 59-65 interferon gamma Homo sapiens 23-31 14988219-6 2004 A combination of I3C and IFNgamma synergistically activated STAT1 proteins by increasing phosphorylation at the Tyr-701 site. Tyrosine 112-115 interferon gamma Homo sapiens 25-33 15115662-0 2004 JNK signaling involved in the effects of cyclic AMP on IL-1beta plus IFNgamma-induced inducible nitric oxide synthase expression in hepatocytes. Cyclic AMP 41-51 interferon gamma Homo sapiens 69-77 15157954-11 2004 RU-486 increased TNF-alpha, IFN-gamma, and IL-2 producing CD4+ and CD8+ cells. Mifepristone 0-6 interferon gamma Homo sapiens 28-37 15157954-12 2004 Surprisingly strong effects were found after MR blocking with spironolactone which increased TNF-alpha, IFN-gamma, and IL-2 producing CD4+ and CD8+ cells. Spironolactone 62-76 interferon gamma Homo sapiens 104-113 15157954-13 2004 No effects on IL-4+CD4+ cells were observed, while the IFN-gamma/IL-4 ratio shifted towards Th1 after spironolactone and after RU-486 plus GH. Spironolactone 102-116 interferon gamma Homo sapiens 55-64 15157954-13 2004 No effects on IL-4+CD4+ cells were observed, while the IFN-gamma/IL-4 ratio shifted towards Th1 after spironolactone and after RU-486 plus GH. Mifepristone 127-133 interferon gamma Homo sapiens 55-64 15115662-1 2004 cAMP significantly inhibits IL-1beta+IFNgamma-induced iNOS gene expression in hepatocytes, but the signaling pathways responsible for the effect are not known. Cyclic AMP 0-4 interferon gamma Homo sapiens 37-45 15210815-5 2004 IFN-gamma caused a decrease in tryptophan concentration on both sides of the epithelium. Tryptophan 31-41 interferon gamma Homo sapiens 0-9 15115662-6 2004 Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation. Nitrites 75-82 interferon gamma Homo sapiens 58-66 15115662-6 2004 Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation. Cyclic AMP 198-202 interferon gamma Homo sapiens 58-66 15115662-6 2004 Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation. Nitrites 206-213 interferon gamma Homo sapiens 58-66 15115662-7 2004 We conclude that JNK signaling plays an important role in the inhibitory effects of cAMP on IL-1beta+IFNgamma-induced iNOS gene expression in cultured hepatocytes. Cyclic AMP 84-88 interferon gamma Homo sapiens 101-109 15182726-0 2004 Trapidil inhibits monocyte CD40 expression by preventing IFN-gamma-induced STAT1 S727 phosphorylation. Trapidil 0-8 interferon gamma Homo sapiens 57-66 15551655-14 2004 Other substances, such as proteoglycans and phosphatidylethanolamine-bound hyaluronic acid, may interfere with the actions of interferon-gamma. phosphatidylethanolamine 44-68 interferon gamma Homo sapiens 126-142 15551655-14 2004 Other substances, such as proteoglycans and phosphatidylethanolamine-bound hyaluronic acid, may interfere with the actions of interferon-gamma. Hyaluronic Acid 75-90 interferon gamma Homo sapiens 126-142 15210815-6 2004 Kynurenine was absent in control conditions, but increased in the basolateral medium after IFN-gamma treatment. Kynurenine 0-10 interferon gamma Homo sapiens 91-100 15244383-12 2004 Analysis of biomarker assays did not identify any biomarker associated with greater response, but a significant increase in levels of soluble intercellular adhesion molecule 1, IL-2, and interferon gamma was seen with thalidomide therapy. Thalidomide 218-229 interferon gamma Homo sapiens 187-203 15200452-5 2004 The +874IFN-gamma AA genotype was associated with type 2/steroid-induced diabetes (P= 0.0127). Steroids 57-64 interferon gamma Homo sapiens 8-17 15374002-7 2004 Furthermore, we found that the induction of IDO activity is responsible for the inhibition of herpes simplex virus replication, since the presence of excess amounts of l-tryptophan abrogates the antiviral effect induced by IFN-gamma and the combination of IFN-gamma and TNF-alpha. Tryptophan 168-180 interferon gamma Homo sapiens 256-265 15374002-6 2004 We found that IFN-gamma induces a strong activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and in addition, that the IFN-gamma-induced IDO activity was enhanced in the presence of TNF-alpha. Tryptophan 59-69 interferon gamma Homo sapiens 14-23 15374002-6 2004 We found that IFN-gamma induces a strong activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and in addition, that the IFN-gamma-induced IDO activity was enhanced in the presence of TNF-alpha. Tryptophan 59-69 interferon gamma Homo sapiens 147-156 15265271-5 2004 Treatment of cultured brain endothelial cells with inflammatory proteins (LPS, IL-1beta, IL-6, IFN-gamma, TNF-alpha) resulted in a significant increase (p < 0.01) in intracellular levels of reactive oxygen species by 1 h. Inflammatory proteins also caused release of tissue plasminogen activator and increased apoptosis by 24 h in these cells. Reactive Oxygen Species 190-213 interferon gamma Homo sapiens 95-104 15374002-7 2004 Furthermore, we found that the induction of IDO activity is responsible for the inhibition of herpes simplex virus replication, since the presence of excess amounts of l-tryptophan abrogates the antiviral effect induced by IFN-gamma and the combination of IFN-gamma and TNF-alpha. Tryptophan 168-180 interferon gamma Homo sapiens 223-232 15292658-7 2004 Unlike macrophages/granulocytes, no respiratory burst was detected in RPE cells, but, comparable to MonoMac6, IFN-gamma induced neopterin in the human RPE. Neopterin 128-137 interferon gamma Homo sapiens 110-119 15082710-13 2004 Ly294002 or a dominant negative PI 3-kinase significantly blocked IFN-gamma-induced MAPK activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 interferon gamma Homo sapiens 66-75 15269982-4 2004 The effects of heparin, low molecular weight heparin (LMW heparin), chondroitin sulfate (CS), hyaluronic acid (HA) and carrageenans on the binding of HBC to IFN-gamma were tested in this system. Carrageenan 119-131 interferon gamma Homo sapiens 157-166 15269982-5 2004 RESULT: Human recombinant IFN-gamma bound to heparin in a concentration dependent manner, the binding of IFN-gamma to HBC was detected at the concentration of 0.25 ng, and saturated at around 2 ng. Heparin 45-52 interferon gamma Homo sapiens 26-35 15269982-5 2004 RESULT: Human recombinant IFN-gamma bound to heparin in a concentration dependent manner, the binding of IFN-gamma to HBC was detected at the concentration of 0.25 ng, and saturated at around 2 ng. Heparin 45-52 interferon gamma Homo sapiens 106-115 15269982-6 2004 Free heparin, LMW heparin, CS,HA and carrageenans competed for the binding of IFN-gamma to HBC with significant different ability. Heparin 5-12 interferon gamma Homo sapiens 78-87 15269982-6 2004 Free heparin, LMW heparin, CS,HA and carrageenans competed for the binding of IFN-gamma to HBC with significant different ability. Heparin, Low-Molecular-Weight 14-25 interferon gamma Homo sapiens 78-87 15269982-6 2004 Free heparin, LMW heparin, CS,HA and carrageenans competed for the binding of IFN-gamma to HBC with significant different ability. Chondroitin Sulfates 27-29 interferon gamma Homo sapiens 78-87 15269982-6 2004 Free heparin, LMW heparin, CS,HA and carrageenans competed for the binding of IFN-gamma to HBC with significant different ability. Carrageenan 37-49 interferon gamma Homo sapiens 78-87 15269982-8 2004 CONCLUSION: IFN-gamma is a cytokine with high binding affinity to heparin and carrageenans family but poor to CS-A and CS-C. ELISA is a simple, sensitive approach to detect the interaction of polysaccharides with cytokine in vitro. Polysaccharides 192-207 interferon gamma Homo sapiens 12-21 15082710-8 2004 Ly294002, a pharmacological inhibitor of phosphatidylinositol (PI) 3-kinase, blocked IFN-gamma-induced PKCepsilon activity and resulted in inhibition of STAT1alpha transcriptional activity but had no effect on STAT1alpha tyrosine phosphorylation and STAT1alpha-DNA complex formation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 interferon gamma Homo sapiens 85-94 15082710-8 2004 Ly294002, a pharmacological inhibitor of phosphatidylinositol (PI) 3-kinase, blocked IFN-gamma-induced PKCepsilon activity and resulted in inhibition of STAT1alpha transcriptional activity but had no effect on STAT1alpha tyrosine phosphorylation and STAT1alpha-DNA complex formation. Phosphatidylinositols 41-61 interferon gamma Homo sapiens 85-94 15082710-8 2004 Ly294002, a pharmacological inhibitor of phosphatidylinositol (PI) 3-kinase, blocked IFN-gamma-induced PKCepsilon activity and resulted in inhibition of STAT1alpha transcriptional activity but had no effect on STAT1alpha tyrosine phosphorylation and STAT1alpha-DNA complex formation. Tyrosine 221-229 interferon gamma Homo sapiens 85-94 15082710-10 2004 However, Ly294002 and H7 blocked IFN-gamma-induced serine phosphorylation of STAT1alpha. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9-17 interferon gamma Homo sapiens 33-42 15082710-10 2004 However, Ly294002 and H7 blocked IFN-gamma-induced serine phosphorylation of STAT1alpha. Serine 51-57 interferon gamma Homo sapiens 33-42 15082710-16 2004 Inhibition of MAPK activity blocked IFN-gamma-induced serine phosphorylation of STAT1alpha; but its tyrosine phosphorylation and DNA binding were partially inhibited. Serine 54-60 interferon gamma Homo sapiens 36-45 15082710-16 2004 Inhibition of MAPK activity blocked IFN-gamma-induced serine phosphorylation of STAT1alpha; but its tyrosine phosphorylation and DNA binding were partially inhibited. Tyrosine 100-108 interferon gamma Homo sapiens 36-45 15193396-2 2004 CEL-1000 and other activators (defensin-beta, CpG ODN, and imiquimod) of the innate immune system promote IFN-gamma-associated protective responses. cel-1000 0-8 interferon gamma Homo sapiens 106-115 15131005-10 2004 Ramipril and valsartan markedly decreased the expression levels of TNF-alpha, IL-6, and iNOS, and, to a lesser extent, of IFN-gamma genes, but did not affect the number of DR+ cells, with no significant difference between the 2 treatments. Ramipril 0-8 interferon gamma Homo sapiens 122-131 15131005-10 2004 Ramipril and valsartan markedly decreased the expression levels of TNF-alpha, IL-6, and iNOS, and, to a lesser extent, of IFN-gamma genes, but did not affect the number of DR+ cells, with no significant difference between the 2 treatments. Valsartan 13-22 interferon gamma Homo sapiens 122-131 15077162-3 2004 We demonstrate that although IFNalpha and TNFalpha alone are unable to induce cell death, they act in synergy with IFNgamma to induce SK-N-MC cell apoptosis. sk-n-mc 134-141 interferon gamma Homo sapiens 115-123 15189935-8 2004 Deposited (99m)Tc-labeled IFN-gamma aerosol was partitioned between upper airways and lungs using attenuation correction measurements. Technetium 15-17 interferon gamma Homo sapiens 26-35 15001472-2 2004 Recently, expression of indoleamine 2,3-dioxygenase (IDO), which is induced by interferon-gamma (IFN-gamma) and catalyzes the conversion from tryptophan to kynurenine, has been identified as a T-cell inhibitory effector pathway in professional antigen-presenting cells. Tryptophan 142-152 interferon gamma Homo sapiens 79-95 15001472-2 2004 Recently, expression of indoleamine 2,3-dioxygenase (IDO), which is induced by interferon-gamma (IFN-gamma) and catalyzes the conversion from tryptophan to kynurenine, has been identified as a T-cell inhibitory effector pathway in professional antigen-presenting cells. Tryptophan 142-152 interferon gamma Homo sapiens 97-106 15001472-2 2004 Recently, expression of indoleamine 2,3-dioxygenase (IDO), which is induced by interferon-gamma (IFN-gamma) and catalyzes the conversion from tryptophan to kynurenine, has been identified as a T-cell inhibitory effector pathway in professional antigen-presenting cells. Kynurenine 156-166 interferon gamma Homo sapiens 79-95 15001472-2 2004 Recently, expression of indoleamine 2,3-dioxygenase (IDO), which is induced by interferon-gamma (IFN-gamma) and catalyzes the conversion from tryptophan to kynurenine, has been identified as a T-cell inhibitory effector pathway in professional antigen-presenting cells. Kynurenine 156-166 interferon gamma Homo sapiens 97-106 15187156-4 2004 The adenosine analog 5"-N-ethylcarboxamidoadenosine (NECA) (10 microM) increased mRNA expression of IL-1beta, IL-3, IL-4, IL-8, and IL-13, but not IL-2 and IFN-gamma. Adenosine 4-13 interferon gamma Homo sapiens 156-165 15187156-4 2004 The adenosine analog 5"-N-ethylcarboxamidoadenosine (NECA) (10 microM) increased mRNA expression of IL-1beta, IL-3, IL-4, IL-8, and IL-13, but not IL-2 and IFN-gamma. Adenosine-5'-(N-ethylcarboxamide) 53-57 interferon gamma Homo sapiens 156-165 15158303-0 2004 Glutamine-enriched enteral nutrition increases in vitro interferon-gamma production but does not influence the in vivo specific antibody response to KLH after severe trauma. Glutamine 0-9 interferon gamma Homo sapiens 56-72 15158303-10 2004 On d14, the IFN-gamma production increased significantly in the glutamine group as compared to the controls. Glutamine 64-73 interferon gamma Homo sapiens 12-21 15158303-15 2004 Glutamine increased IFN-gamma production (d14), maintained a normal IL-4 production, but was not acquired for the development of KLH-specific humoral response on d14, in sync suggesting that dietary glutamine supports the restoration of the Type-1 T-lymphocyte responsiveness. Glutamine 0-9 interferon gamma Homo sapiens 20-29 15188166-9 2004 Inhibition of electrogenic sodium transport as well as beta- and gamma-ENaC mRNA expression could be mimicked in control colon by in vitro preexposure for 8 hours to tumor necrosis factor alpha and interferon gamma. Sodium 27-33 interferon gamma Homo sapiens 198-214 15135313-4 2004 When macrophages were primed with IFN-gamma, resveratrol suppressed the expression of HLA-ABC, HLA-DR, CD80, CD86 and inhibited production of TNF-alpha, IL-12, IL-6 and IL-1beta induced by LPS. Resveratrol 45-56 interferon gamma Homo sapiens 34-43 15135313-5 2004 The differential impact of resveratrol on expression of CD14 might be correlated with differential response of macrophages to LPS with or without IFN-gamma priming. Resveratrol 27-38 interferon gamma Homo sapiens 146-155 15135323-0 2004 PADMA 28 modulates interferon-gamma-induced tryptophan degradation and neopterin production in human PBMC in vitro. Tryptophan 44-54 interferon gamma Homo sapiens 19-35 15135323-8 2004 The suppression of neopterin production and tryptophan degradation suggests a specific influence on biochemical pathways induced by Th1-type cytokine interferon-gamma. Neopterin 19-28 interferon gamma Homo sapiens 150-166 15135323-8 2004 The suppression of neopterin production and tryptophan degradation suggests a specific influence on biochemical pathways induced by Th1-type cytokine interferon-gamma. Tryptophan 44-54 interferon gamma Homo sapiens 150-166 15173890-2 2004 We demonstrate here that the NKT cell production of IFN-gamma is more susceptible to the sphingosine length of glycolipid ligand than that of IL-4 and that the length of the sphingosine chain determines the duration of NKT cell stimulation by CD1d-associated glycolipids. Sphingosine 89-100 interferon gamma Homo sapiens 52-61 15187450-0 2004 Increased in vitro release of interferon-gamma from ampicillin-stimulated peripheral blood mononuclear cells in Stevens-Johnson syndrome. Ampicillin 52-62 interferon gamma Homo sapiens 30-46 15187450-4 2004 IFN-gamma release increased by 52% following the in vitro challenge of the patient"s peripheral blood mononuclear cells (PBMCs) with 15 microg/ml of ampicillin, but not with phenytoin or furosemide. Ampicillin 149-159 interferon gamma Homo sapiens 0-9 15187450-6 2004 In the present case, increased in vitro IFN-gamma release was observed on ampicillin-stimulated PBMCs, which may indicate the role of ampicillin as the drug responsible for the induction of SJS, and may imply the role of IFN-gamma in the pathogenesis of SJS. Ampicillin 74-84 interferon gamma Homo sapiens 40-49 15187450-6 2004 In the present case, increased in vitro IFN-gamma release was observed on ampicillin-stimulated PBMCs, which may indicate the role of ampicillin as the drug responsible for the induction of SJS, and may imply the role of IFN-gamma in the pathogenesis of SJS. Ampicillin 74-84 interferon gamma Homo sapiens 221-230 15187450-6 2004 In the present case, increased in vitro IFN-gamma release was observed on ampicillin-stimulated PBMCs, which may indicate the role of ampicillin as the drug responsible for the induction of SJS, and may imply the role of IFN-gamma in the pathogenesis of SJS. Ampicillin 134-144 interferon gamma Homo sapiens 40-49 15020655-3 2004 3S-DS down-regulated nuclear factor-kappaB activity and reduced the secretion of TNF-alpha and interferon-gamma (IFN-gamma) by anti-CD3-activated T cells. 3s-ds 0-5 interferon gamma Homo sapiens 95-111 15020655-3 2004 3S-DS down-regulated nuclear factor-kappaB activity and reduced the secretion of TNF-alpha and interferon-gamma (IFN-gamma) by anti-CD3-activated T cells. 3s-ds 0-5 interferon gamma Homo sapiens 113-122 15173890-2 2004 We demonstrate here that the NKT cell production of IFN-gamma is more susceptible to the sphingosine length of glycolipid ligand than that of IL-4 and that the length of the sphingosine chain determines the duration of NKT cell stimulation by CD1d-associated glycolipids. Glycolipids 111-121 interferon gamma Homo sapiens 52-61 15173890-2 2004 We demonstrate here that the NKT cell production of IFN-gamma is more susceptible to the sphingosine length of glycolipid ligand than that of IL-4 and that the length of the sphingosine chain determines the duration of NKT cell stimulation by CD1d-associated glycolipids. Sphingosine 174-185 interferon gamma Homo sapiens 52-61 15173890-2 2004 We demonstrate here that the NKT cell production of IFN-gamma is more susceptible to the sphingosine length of glycolipid ligand than that of IL-4 and that the length of the sphingosine chain determines the duration of NKT cell stimulation by CD1d-associated glycolipids. Glycolipids 259-270 interferon gamma Homo sapiens 52-61 15173890-4 2004 Interestingly, transcription of IFN-gamma but not that of IL-4 was sensitive to cycloheximide treatment, indicating the intrinsic involvement of de novo protein synthesis for IFN-gamma production by NKT cells. Cycloheximide 80-93 interferon gamma Homo sapiens 32-41 15173890-4 2004 Interestingly, transcription of IFN-gamma but not that of IL-4 was sensitive to cycloheximide treatment, indicating the intrinsic involvement of de novo protein synthesis for IFN-gamma production by NKT cells. Cycloheximide 80-93 interferon gamma Homo sapiens 175-184 15124217-0 2004 Benzyl alcohol-induced destabilization of interferon-gamma: a study by hydrogen-deuterium isotope exchange. Benzyl Alcohol 0-14 interferon gamma Homo sapiens 42-58 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Catecholamines 11-24 interferon gamma Homo sapiens 187-209 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Epinephrine 26-37 interferon gamma Homo sapiens 187-209 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Norepinephrine 42-56 interferon gamma Homo sapiens 187-209 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Isoproterenol 62-75 interferon gamma Homo sapiens 187-209 15124217-0 2004 Benzyl alcohol-induced destabilization of interferon-gamma: a study by hydrogen-deuterium isotope exchange. Hydrogen 71-79 interferon gamma Homo sapiens 42-58 15124217-0 2004 Benzyl alcohol-induced destabilization of interferon-gamma: a study by hydrogen-deuterium isotope exchange. Deuterium 80-89 interferon gamma Homo sapiens 42-58 15124217-1 2004 The destabilizing effect of a multidose preservative, benzyl alcohol, on IFN-gamma was investigated. Benzyl Alcohol 54-68 interferon gamma Homo sapiens 73-82 15120628-4 2004 Furthermore, Glu modulated cytokine secretion by anti-CD3 mAb activated PBMC: it increased IFN-gamma (+44.3+/-8.2%) and IL-10 (+31.6+/-9.7%) secretion, whereas that of IL-2, IL-4, IL-5, and TNF-alpha was not affected. Glutamic Acid 13-16 interferon gamma Homo sapiens 91-100 15288189-5 2004 In contrast, analysis of IFN-gamma production by polyclonal activated lymphocytes from endometrium and/or peripheral blood from fertile women showed a significant increase compared to RSM. (2s)-2-(Acetylamino)-N-Methyl-4-[(R)-Methylsulfinyl]butanamide 184-187 interferon gamma Homo sapiens 25-34 15007079-3 2004 We have demonstrated previously that, in interferon-gamma-primed U937 cells, the high affinity receptor for IgG, FcgammaRI, is coupled to a novel intracellular signaling pathway that involves the sequential activation of phospholipase D, sphingosine kinase, calcium transients, and protein kinase C isoforms, leading to the activation of the NADPH-oxidative burst. NADP 342-347 interferon gamma Homo sapiens 41-57 15142195-9 2004 However, production of interferon-gamma by concanavalin A-stimulated peripheral blood mononuclear cells was lower in active Crohn"s disease (P = 0.02) and correlated negatively with the deoxypyridinoline/creatinine:osteocalcin ratio (r = -0.40, P = 0.004). deoxypyridinoline 186-203 interferon gamma Homo sapiens 23-39 15142195-9 2004 However, production of interferon-gamma by concanavalin A-stimulated peripheral blood mononuclear cells was lower in active Crohn"s disease (P = 0.02) and correlated negatively with the deoxypyridinoline/creatinine:osteocalcin ratio (r = -0.40, P = 0.004). Creatinine 204-214 interferon gamma Homo sapiens 23-39 15094367-5 2004 After intravenous administration, OVA mRNA expression and MHC class I-restricted antigen presentation on CD11c+ cells and inflammatory cytokines, such as TNF-alpha, IL-12, and IFN-gamma, that can enhance the Th1 response of the Man liposome/pCMV-OVA complex were higher than that of naked pCMV-OVA and that complexed with DC-Chol liposomes. pcmv 241-245 interferon gamma Homo sapiens 176-185 15150095-5 2004 A combination of IFN-gamma and rapamycin is markedly synergistic in induction of apoptosis in Tsc1 or Tsc2 null cells because pSTAT3 Tyr705 phosphorylation is abolished completely and the other effects of IFN-gamma are maintained or enhanced. Sirolimus 31-40 interferon gamma Homo sapiens 205-214 15150095-6 2004 Rapamycin-IFN-gamma has unique potential therapeutic benefit for management of TSC tumors. Sirolimus 0-9 interferon gamma Homo sapiens 10-19 14993214-8 2004 Electrophoretic mobility shift assay analysis demonstrated that IFN-gamma induces a complex between an oligonucleotide probe containing the ISRE motif and IRF-1 over a similar time scale to the induction of caspase-8 mRNA. Oligonucleotides 103-118 interferon gamma Homo sapiens 64-73 15094367-5 2004 After intravenous administration, OVA mRNA expression and MHC class I-restricted antigen presentation on CD11c+ cells and inflammatory cytokines, such as TNF-alpha, IL-12, and IFN-gamma, that can enhance the Th1 response of the Man liposome/pCMV-OVA complex were higher than that of naked pCMV-OVA and that complexed with DC-Chol liposomes. pcmv-ova 241-249 interferon gamma Homo sapiens 176-185 15094367-5 2004 After intravenous administration, OVA mRNA expression and MHC class I-restricted antigen presentation on CD11c+ cells and inflammatory cytokines, such as TNF-alpha, IL-12, and IFN-gamma, that can enhance the Th1 response of the Man liposome/pCMV-OVA complex were higher than that of naked pCMV-OVA and that complexed with DC-Chol liposomes. 3-(N-(N',N'-dimethylaminoethane)carbamoyl)cholesterol 322-329 interferon gamma Homo sapiens 176-185 15229385-4 2004 By ELISA analysis, we showed that carvedilol inhibited interferon-gamma (IFN-gamma), but enhanced interleukin (IL)-12 production in phytohemagglutinin (PHA)- and concanavalin A (ConA)-stimulated human peripheral blood mononuclear cells (PBMCs). Carvedilol 34-44 interferon gamma Homo sapiens 55-71 15229385-4 2004 By ELISA analysis, we showed that carvedilol inhibited interferon-gamma (IFN-gamma), but enhanced interleukin (IL)-12 production in phytohemagglutinin (PHA)- and concanavalin A (ConA)-stimulated human peripheral blood mononuclear cells (PBMCs). Carvedilol 34-44 interferon gamma Homo sapiens 73-82 15115509-3 2004 Topical tacrolimus may inhibit local activation of T lymphocytes through altered expression of cytokines such as interleukin-1, -4 and -5, tumour necrosis factor-alpha and interferon-gamma. Tacrolimus 8-18 interferon gamma Homo sapiens 172-188 15110894-5 2004 Since topotecan pretreatment differentially influenced CpG-ODN-induced production of IL-12 and IFN-gamma, the antitumour effects of the two therapies were investigated in a sequential (full topotecan regimen followed by CpG-ODN) or in an alternating sequence (starting with CpG-ODN). cpg-odn 55-62 interferon gamma Homo sapiens 95-104 14648070-7 2004 Although no clinical responses were observed, results of this pilot study demonstrated that treatment of HNSCC patients with 25-hydroxyvitamin D(3 )reduces the number of immune suppressive CD34(+) cells, increases HLA-DR expression, increases plasma IL-12 and IFN-gamma levels, and improves T-cell blastogenesis. Calcifediol 125-148 interferon gamma Homo sapiens 260-269 15102781-1 2004 Tryptophan depletion resulting from indoleamine 2,3-dioxygenase (IDO) activity within the kynurenine pathway is one of the most prominent gamma interferon (IFN-gamma)-inducible antimicrobial effector mechanisms in human cells. Tryptophan 0-10 interferon gamma Homo sapiens 138-165 15070879-10 2004 Indoleamine 2,3-dioxygenase activity (determined by measuring the concentration of tryptophan and its indoleamine 2,3-dioxygenase catabolite, kynurenine) was also decreased by progesterone-induced decidualization but enhanced following interferon-gamma treatment. Progesterone 176-188 interferon gamma Homo sapiens 236-252 15102781-1 2004 Tryptophan depletion resulting from indoleamine 2,3-dioxygenase (IDO) activity within the kynurenine pathway is one of the most prominent gamma interferon (IFN-gamma)-inducible antimicrobial effector mechanisms in human cells. Kynurenine 90-100 interferon gamma Homo sapiens 138-165 15102781-5 2004 These findings were supported by experiments which showed that IDO activity in extracts of IFN-gamma-stimulated cells is inhibited by the chemical NO donors diethylenetriamine diazeniumdiolate, S-nitroso-L-cysteine, and S-nitroso-N-acetyl-D,L-penicillamine. diethylenetriamine diazeniumdiolate 157-192 interferon gamma Homo sapiens 91-100 15102781-5 2004 These findings were supported by experiments which showed that IDO activity in extracts of IFN-gamma-stimulated cells is inhibited by the chemical NO donors diethylenetriamine diazeniumdiolate, S-nitroso-L-cysteine, and S-nitroso-N-acetyl-D,L-penicillamine. S-nitrosocysteine 194-214 interferon gamma Homo sapiens 91-100 15102781-5 2004 These findings were supported by experiments which showed that IDO activity in extracts of IFN-gamma-stimulated cells is inhibited by the chemical NO donors diethylenetriamine diazeniumdiolate, S-nitroso-L-cysteine, and S-nitroso-N-acetyl-D,L-penicillamine. snap 220-256 interferon gamma Homo sapiens 91-100 15345185-2 2004 Beryllium presentation to CD4+ T cells from patients with berylliosis results in T cell activation and these Be-specific CD4+ T cells undergo clonal proliferation and Th1-type cytokine production such as interleukin-2, interferon-gamma and tumor necrosis factor-alpha. Beryllium 0-9 interferon gamma Homo sapiens 219-267 15345194-6 2004 We found that the addiction on NiSo4 to the PBMC cultures of non sensitised subjects induces a reduction of release of IL5, IFN gamma and TNFalpha. nickel sulfate 31-36 interferon gamma Homo sapiens 124-133 15345202-5 2004 On the other hand, 10(-4) M Ti oxalate (with wide industrial applications) and Ti ascorbate (used mainly in agriculture) inhibited about 70% the PHA stimulate PBMC proliferation; both these Ti compounds at 10(-4) and 10(-7) M concentrations significantly inhibited TNF-alpha release, while only Ti oxalate inhibited that of IFN-gamma. ti oxalate 28-38 interferon gamma Homo sapiens 324-333 15100320-0 2004 Monosodium urate crystals synergize with IFN-gamma to generate macrophage nitric oxide: involvement of extracellular signal-regulated kinase 1/2 and NF-kappa B. Nitric Oxide 74-86 interferon gamma Homo sapiens 41-50 15345202-5 2004 On the other hand, 10(-4) M Ti oxalate (with wide industrial applications) and Ti ascorbate (used mainly in agriculture) inhibited about 70% the PHA stimulate PBMC proliferation; both these Ti compounds at 10(-4) and 10(-7) M concentrations significantly inhibited TNF-alpha release, while only Ti oxalate inhibited that of IFN-gamma. Ascorbic Acid 82-91 interferon gamma Homo sapiens 324-333 15345202-6 2004 Titanocene (used in chemotherapy) did no exert effects on PBMC proliferation but markedly inhibited IFN-gamma and TNF-alpha release. titanocene 0-10 interferon gamma Homo sapiens 100-109 15086600-8 2004 In addition, 0.1 microg/mL ribavirin could upregulate the levels of IFN-gamma or IL-4 mRNA in some cases. Ribavirin 27-36 interferon gamma Homo sapiens 68-77 15068904-9 2004 The cytokine response profiles as determined by [(3)H]-thymidine incorporation assay were: 2-to-12 fold growth stimulation of MUTZ-11 by GM-CSF, IFN-alpha (interferon), IFN-beta, IFN-gamma, IL-3 and SCF (stem cell factor); growth inhibition by TGF-beta1 (transforming growth factor), TNF-alpha (tumor necrosis factor) and TNF-beta. mutz-11 126-133 interferon gamma Homo sapiens 179-188 15100326-6 2004 More importantly, gemfibrozil was shown to shift the cytokine secretion of human T cell lines by inhibiting IFN-gamma and promoting IL-4 secretion. Gemfibrozil 18-29 interferon gamma Homo sapiens 108-117 14996826-5 2004 In vitro, IFN-gamma and TLR3 ligation by double-stranded RNA (dsRNA) induced the expression of CXCL9 and CXCL11 in leukocytes and skin-muscle fibroblasts, whereas ligation of TLR2, TLR4, TLR5, and TLR9 by peptidoglycan (PGN), lipopolysaccharide (LPS), flagellin, and unmethylated CpG oligonucleotides, respectively, did not. CPG-oligonucleotide 280-300 interferon gamma Homo sapiens 10-19 15081243-0 2004 Tissue specific effects of the beta 2-adrenergic agonist salbutamol on LPS-induced IFN-gamma, IL-10 and TGF-beta responses in vivo. Albuterol 57-67 interferon gamma Homo sapiens 83-92 15081243-4 2004 Salbutamol reduced LPS-induced IFN-gamma levels at both mucosal and non-mucosal sites. Albuterol 0-10 interferon gamma Homo sapiens 31-40 15081243-7 2004 Thus, orally administered salbutamol decreases LPS-induced IFN-gamma levels in all tissues tested, but has tissue specific effects on IL-10 and TGF-beta levels. Albuterol 26-36 interferon gamma Homo sapiens 59-68 15273801-6 2004 After treatment with rifampicina, isoniazida, and pirazinamida, only the levels of IFN-gamma increased significantly (p < 0.01). Rifampin 21-32 interferon gamma Homo sapiens 83-92 15273801-6 2004 After treatment with rifampicina, isoniazida, and pirazinamida, only the levels of IFN-gamma increased significantly (p < 0.01). Isoniazid 34-44 interferon gamma Homo sapiens 83-92 15189689-14 2004 Expression of mRNA for IL-12p35, IL-12p40, IFN-gamma in the cells that had been incubated with RA declined, but IL-10, IL-4 increased significantly. Tretinoin 95-97 interferon gamma Homo sapiens 43-52 14976356-9 2004 However, the type 1-associated parameters (CD8(+) cells, macrophages, IFN-gamma, TNF-alpha, and IL-1 beta) that are induced in the PLN by streptozotocin were less pronounced in the ALN. Streptozocin 138-152 interferon gamma Homo sapiens 70-79 15044085-4 2004 Here, we show that CD4(+) and CD8(+) T cells producing IFN-gamma and IL-2 were reduced by DP-mediated signals, while CRTH2-mediated signals enhanced IL-2, IL-4, IL-5, and IL-13 production by Th2 cells. dp 90-92 interferon gamma Homo sapiens 55-64 15051500-5 2004 The IFNgamma-activated p70 S6 kinase subsequently phosphorylates the 40S S6 ribosomal protein on serines 235/236, to regulate IFNgamma-dependent mRNA translation. Serine 97-104 interferon gamma Homo sapiens 4-12 15051500-5 2004 The IFNgamma-activated p70 S6 kinase subsequently phosphorylates the 40S S6 ribosomal protein on serines 235/236, to regulate IFNgamma-dependent mRNA translation. Serine 97-104 interferon gamma Homo sapiens 126-134 15051500-6 2004 In addition to phosphorylation of 40S ribosomal protein, IFNgamma also induces phosphorylation of the 4E-BP1 repressor of mRNA translation on threonines 37/46, threonine 70, and serine 65, sites whose phosphorylation is required for the inactivation of 4E-BP1 and its dissociation from the eukaryotic initiation factor-4E (eIF4E) complex. Threonine 142-152 interferon gamma Homo sapiens 57-65 15051500-6 2004 In addition to phosphorylation of 40S ribosomal protein, IFNgamma also induces phosphorylation of the 4E-BP1 repressor of mRNA translation on threonines 37/46, threonine 70, and serine 65, sites whose phosphorylation is required for the inactivation of 4E-BP1 and its dissociation from the eukaryotic initiation factor-4E (eIF4E) complex. Threonine 142-151 interferon gamma Homo sapiens 57-65 15051500-6 2004 In addition to phosphorylation of 40S ribosomal protein, IFNgamma also induces phosphorylation of the 4E-BP1 repressor of mRNA translation on threonines 37/46, threonine 70, and serine 65, sites whose phosphorylation is required for the inactivation of 4E-BP1 and its dissociation from the eukaryotic initiation factor-4E (eIF4E) complex. Serine 178-184 interferon gamma Homo sapiens 57-65 15067074-2 2004 In this study, we show that the effect of IFN-gamma is reproduced by the serine phosphatase inhibitor, okadaic acid, and this suggests that serine kinases could be involved in gp91(phox) expression. Okadaic Acid 103-115 interferon gamma Homo sapiens 42-51 15067074-3 2004 We also show that IFN-gamma induces the serine/threonine phosphorylation of PU.1 in cultured monocytes. Serine 40-46 interferon gamma Homo sapiens 18-27 15067074-3 2004 We also show that IFN-gamma induces the serine/threonine phosphorylation of PU.1 in cultured monocytes. Threonine 47-56 interferon gamma Homo sapiens 18-27 15067074-4 2004 This phosphorylation, as well as the IFN-gamma-induced PU.1 binding and gp91(phox) protein synthesis, is slightly affected by the casein kinase II inhibitor, daidzein, but is abrogated by the protein kinase C (PKC) -alpha and -beta inhibitor, Go6976, and by synthetic peptides with sequences based on the endogenous pseudosubstrate region of the classical PKC alpha and beta isoforms. daidzein 158-166 interferon gamma Homo sapiens 37-46 15067074-4 2004 This phosphorylation, as well as the IFN-gamma-induced PU.1 binding and gp91(phox) protein synthesis, is slightly affected by the casein kinase II inhibitor, daidzein, but is abrogated by the protein kinase C (PKC) -alpha and -beta inhibitor, Go6976, and by synthetic peptides with sequences based on the endogenous pseudosubstrate region of the classical PKC alpha and beta isoforms. Go 6976 243-249 interferon gamma Homo sapiens 37-46 15067074-4 2004 This phosphorylation, as well as the IFN-gamma-induced PU.1 binding and gp91(phox) protein synthesis, is slightly affected by the casein kinase II inhibitor, daidzein, but is abrogated by the protein kinase C (PKC) -alpha and -beta inhibitor, Go6976, and by synthetic peptides with sequences based on the endogenous pseudosubstrate region of the classical PKC alpha and beta isoforms. Peptides 268-276 interferon gamma Homo sapiens 37-46 15067074-6 2004 Moreover, we found that the treatment of monocytes with IFN-gamma induces the nuclear translocation and the activation of PKC alpha and beta I, but not of PKC beta II, and that the IFN-gamma-induced phosphorylation of PU.1 was greatly reduced by LY333531, a selective inhibitor of PKC beta isoforms. ruboxistaurin 246-254 interferon gamma Homo sapiens 56-65 15067074-6 2004 Moreover, we found that the treatment of monocytes with IFN-gamma induces the nuclear translocation and the activation of PKC alpha and beta I, but not of PKC beta II, and that the IFN-gamma-induced phosphorylation of PU.1 was greatly reduced by LY333531, a selective inhibitor of PKC beta isoforms. ruboxistaurin 246-254 interferon gamma Homo sapiens 181-190 15067074-7 2004 Finally, nuclear run-on assays demonstrated that while the PKC inhibitors, Go6976 and LY333531, decrease the IFN-gamma-induced gp91(phox) transcription, the serine phosphatase inhibitor, okadaic acid, enhances the gp91(phox) gene transcription. Go 6976 75-81 interferon gamma Homo sapiens 109-118 15067074-7 2004 Finally, nuclear run-on assays demonstrated that while the PKC inhibitors, Go6976 and LY333531, decrease the IFN-gamma-induced gp91(phox) transcription, the serine phosphatase inhibitor, okadaic acid, enhances the gp91(phox) gene transcription. ruboxistaurin 86-94 interferon gamma Homo sapiens 109-118 15067074-7 2004 Finally, nuclear run-on assays demonstrated that while the PKC inhibitors, Go6976 and LY333531, decrease the IFN-gamma-induced gp91(phox) transcription, the serine phosphatase inhibitor, okadaic acid, enhances the gp91(phox) gene transcription. Okadaic Acid 187-199 interferon gamma Homo sapiens 109-118 15030379-5 2004 A slight decrease in L-DOPA tissue levels, no changes in AADC activity and an increase in plasma IFN-gamma levels accompanied this decrease in dopamine levels. Dopamine 143-151 interferon gamma Homo sapiens 97-106 15030379-0 2004 Decreased availability of intestinal dopamine in transmural colitis may relate to inhibitory effects of interferon-gamma upon L-DOPA uptake. Dopamine 37-45 interferon gamma Homo sapiens 104-120 15030379-6 2004 Exposure of Caco-2 cells, a human intestinal epithelial cell line, to human IFN-gamma resulted in a concentration-dependent and long-lasting inhibition of L-DOPA uptake, which most likely explains the decrease in dopamine levels in the inflamed mucosa. Levodopa 155-161 interferon gamma Homo sapiens 76-85 15030379-0 2004 Decreased availability of intestinal dopamine in transmural colitis may relate to inhibitory effects of interferon-gamma upon L-DOPA uptake. Levodopa 126-132 interferon gamma Homo sapiens 104-120 15030379-6 2004 Exposure of Caco-2 cells, a human intestinal epithelial cell line, to human IFN-gamma resulted in a concentration-dependent and long-lasting inhibition of L-DOPA uptake, which most likely explains the decrease in dopamine levels in the inflamed mucosa. Dopamine 213-221 interferon gamma Homo sapiens 76-85 15030379-8 2004 In this model of experimental colitis, the decrease in dopamine levels is most likely explained by the inhibitory effect of IFN-gamma on L-DOPA uptake by intestinal epithelial cells. Dopamine 55-63 interferon gamma Homo sapiens 124-133 15030379-8 2004 In this model of experimental colitis, the decrease in dopamine levels is most likely explained by the inhibitory effect of IFN-gamma on L-DOPA uptake by intestinal epithelial cells. Levodopa 137-143 interferon gamma Homo sapiens 124-133 15212685-2 2004 The aim of this study was to evaluate the effects of interferon (IFN)-gamma on the expression of Cyclooxygenase (COX)-2 and production of prostaglandin E(2) (PGE(2)) in the human placenta from term and preterm labor deliveries. Dinoprostone 138-156 interferon gamma Homo sapiens 53-75 15282113-3 2004 Results from a previous study in our laboratory, in the human A172 astroglial cell line, revealed that induction of iNOS activity by tumor necrosis factor-alpha + interferon-gamma + interleukin-1 beta was inhibited by 24-h exposure to a high ethanol concentration (200 mM), but enhanced by 50 mM ethanol. Ethanol 242-249 interferon gamma Homo sapiens 163-179 15282113-3 2004 Results from a previous study in our laboratory, in the human A172 astroglial cell line, revealed that induction of iNOS activity by tumor necrosis factor-alpha + interferon-gamma + interleukin-1 beta was inhibited by 24-h exposure to a high ethanol concentration (200 mM), but enhanced by 50 mM ethanol. Ethanol 296-303 interferon gamma Homo sapiens 163-179 15212685-2 2004 The aim of this study was to evaluate the effects of interferon (IFN)-gamma on the expression of Cyclooxygenase (COX)-2 and production of prostaglandin E(2) (PGE(2)) in the human placenta from term and preterm labor deliveries. Dinoprostone 158-164 interferon gamma Homo sapiens 53-75 15212685-8 2004 IFN-gamma significantly inhibited COX-2 expression and PGE(2) release in cultured placental explants from term and preterm labor deliveries. Dinoprostone 55-61 interferon gamma Homo sapiens 0-9 15212685-13 2004 CONCLUSIONS: Our data suggest that the human placenta is an important site for IFN-gamma-mediated repression of COX-2 expression and PGE2 production, implying that functional withdrawal of IFN-gamma may be involved in the onset of term or preterm labor. Dinoprostone 133-137 interferon gamma Homo sapiens 79-88 14977878-6 2004 Likely related to tolerance induction, biliverdin interferes with T cell signaling by inhibiting activation of nuclear factor of activated T cells (NFAT) and nuclear factor kappaB (NF-kappaB), two transcription factors involved in interleukin-2 (IL-2) transcription and T cell proliferation, as well as suppressing Th1 interferon-gamma (IFN-gamma) production in vitro. Biliverdine 39-49 interferon gamma Homo sapiens 337-346 15023855-0 2004 Differential regulation of prostaglandin E biosynthesis by interferon-gamma in colonic epithelial cells. Prostaglandins E 27-42 interferon gamma Homo sapiens 59-75 15023855-10 2004 TNF alpha-induced PGE(2) biosynthesis was significantly enhanced by the simultaneous addition of IFN gamma and was COX-2 dependent. Dinoprostone 18-24 interferon gamma Homo sapiens 97-106 15023855-12 2004 The combination of IFN gamma and TNF alpha induced the microsomal prostaglandin E synthase (mPGES), comensurate with the enhanced PGE(2) synthesis. Prostaglandins E 93-96 interferon gamma Homo sapiens 19-28 15023855-14 2004 These results suggest that, in terms of PGE(2) biosynthesis, IFN gamma plays a negative regulatory role at the level of COX-2 expression and a positive regulatory role at the level of mPGES expression. Dinoprostone 40-46 interferon gamma Homo sapiens 61-70 15099362-9 2004 CONCLUSIONS: The results indicate that proinflammatory type 1 genes regulated by IFN-gamma are similarly increased in both SP and LP psoriasis, but a potential difference in IL-18 exists between these disease forms. sp 123-125 interferon gamma Homo sapiens 81-90 15099362-9 2004 CONCLUSIONS: The results indicate that proinflammatory type 1 genes regulated by IFN-gamma are similarly increased in both SP and LP psoriasis, but a potential difference in IL-18 exists between these disease forms. leucylproline 130-132 interferon gamma Homo sapiens 81-90 15080812-10 2004 IL-13 and IFN-gamma by CBMC was not influenced by maternal atopy, but IFN-gamma was less commonly detected in samples with IC. cbmc 23-27 interferon gamma Homo sapiens 10-19 15095451-3 2004 The monoclonal antibody labeled with fluorescein isothiocyanate of IFN-gamma was hydrodynamically injected into the front end of the capillary around the cell introduced. Fluorescein-5-isothiocyanate 37-63 interferon gamma Homo sapiens 67-76 15034076-9 2004 Stimulation of T cells from nonpregnant females with PMA/ionomycin resulted in IkappaBalpha degradation, p65 translocation, and subsequent production of the Th1 cytokines IFN-gamma and IL-2. Tetradecanoylphorbol Acetate 53-56 interferon gamma Homo sapiens 171-180 15034076-9 2004 Stimulation of T cells from nonpregnant females with PMA/ionomycin resulted in IkappaBalpha degradation, p65 translocation, and subsequent production of the Th1 cytokines IFN-gamma and IL-2. Ionomycin 57-66 interferon gamma Homo sapiens 171-180 15063632-5 2004 Indoleamine 2,3-dioxygenase-mediated tryptophan degradation in the first trimester villous and decidual tissue explants is stimulated by interferon-gamma and inhibited by 1-methyl-tryptophan (an inhibitor of indoleamine 2,3-dioxygenase). Tryptophan 37-47 interferon gamma Homo sapiens 137-153 18958643-6 2004 Both male and female offspring of the TCDD-treated dams demonstrated impairment of the adaptive immune response, as evidenced by suppressed numbers of T cells and IFNgamma-producing cells in the draining lymph nodes and reduced T cell recruitment to the lung. Polychlorinated Dibenzodioxins 38-42 interferon gamma Homo sapiens 163-171 15203549-6 2004 IFN-gamma serum concentrations were significantly lower in the UC compared with those in controls (p < 0.04), increasing significantly up to 5N (p < 0.03). 5-doxylstearic acid 144-146 interferon gamma Homo sapiens 0-9 15849402-3 2004 Neopterin synthesis is the sum of all positive and negative regulating factors on the monocyte/macrophage populations activated by interferon-gamma, which is mainly produced by activated T lymphocytes. Neopterin 0-9 interferon gamma Homo sapiens 131-147 15006553-5 2004 In the T cells stimulated with mitogenic lectin phytohemagglutinin (PHA) in conjunction with phorbol myristate acetate (PMA), 6-formylpterin suppressed the NF-kappaB-dependent transcription, the production of cytokines (IFN-gamma and IL-2) and the cell proliferation. Tetradecanoylphorbol Acetate 93-118 interferon gamma Homo sapiens 220-229 15044927-7 2004 Interestingly, GM1bright GL were demonstrated to contain a higher amount of IFN-gamma as compared to GM1dull GL. gm1bright gl 15-27 interferon gamma Homo sapiens 76-85 15006553-5 2004 In the T cells stimulated with mitogenic lectin phytohemagglutinin (PHA) in conjunction with phorbol myristate acetate (PMA), 6-formylpterin suppressed the NF-kappaB-dependent transcription, the production of cytokines (IFN-gamma and IL-2) and the cell proliferation. Tetradecanoylphorbol Acetate 120-123 interferon gamma Homo sapiens 220-229 15006553-5 2004 In the T cells stimulated with mitogenic lectin phytohemagglutinin (PHA) in conjunction with phorbol myristate acetate (PMA), 6-formylpterin suppressed the NF-kappaB-dependent transcription, the production of cytokines (IFN-gamma and IL-2) and the cell proliferation. 2-amino-4-hydroxy-6-formylpteridine 126-140 interferon gamma Homo sapiens 220-229 14992891-4 2004 The expression of IFN-gamma is influenced by a dinucleotide repeat in the first intron of the IFN-gamma gene. Dinucleoside Phosphates 47-59 interferon gamma Homo sapiens 18-27 14992891-4 2004 The expression of IFN-gamma is influenced by a dinucleotide repeat in the first intron of the IFN-gamma gene. Dinucleoside Phosphates 47-59 interferon gamma Homo sapiens 94-103 14749055-14 2004 In conclusion, production and/or expression of uterine TGF-beta2, IL-6 and PGE(2) increased during the embryonic attachment period and are coincidental with embryonic interferon-gamma production. Prostaglandins E 75-78 interferon gamma Homo sapiens 167-183 14992891-12 2004 CONCLUSIONS: Dinucleotide repeat polymorphism in the first intron of the human IFN-gamma gene does not influence CV development and cannot be used as a genetic risk marker. Dinucleoside Phosphates 13-25 interferon gamma Homo sapiens 79-88 15022319-8 2004 T cells, in turn, responded to FLS stimulation by secreting higher amounts of IL-17 and IFN gamma in coculture. CHEMBL1232769 31-34 interferon gamma Homo sapiens 88-97 14648016-1 2004 PURPOSE: The study objectives were to define subcutaneous (s.c.) interferon gamma (IFN-gamma) disposition in patients with gastrointestinal malignancies receiving 5-fluorouracil (5-FU) and leucovorin (LV) and to examine the relationship between IFN-gamma exposures and Fas upregulation in vivo and in vitro. Fluorouracil 163-177 interferon gamma Homo sapiens 65-92 14648016-1 2004 PURPOSE: The study objectives were to define subcutaneous (s.c.) interferon gamma (IFN-gamma) disposition in patients with gastrointestinal malignancies receiving 5-fluorouracil (5-FU) and leucovorin (LV) and to examine the relationship between IFN-gamma exposures and Fas upregulation in vivo and in vitro. Fluorouracil 163-177 interferon gamma Homo sapiens 83-92 14648016-1 2004 PURPOSE: The study objectives were to define subcutaneous (s.c.) interferon gamma (IFN-gamma) disposition in patients with gastrointestinal malignancies receiving 5-fluorouracil (5-FU) and leucovorin (LV) and to examine the relationship between IFN-gamma exposures and Fas upregulation in vivo and in vitro. Fluorouracil 179-183 interferon gamma Homo sapiens 65-92 14648016-1 2004 PURPOSE: The study objectives were to define subcutaneous (s.c.) interferon gamma (IFN-gamma) disposition in patients with gastrointestinal malignancies receiving 5-fluorouracil (5-FU) and leucovorin (LV) and to examine the relationship between IFN-gamma exposures and Fas upregulation in vivo and in vitro. Fluorouracil 179-183 interferon gamma Homo sapiens 83-92 14648016-1 2004 PURPOSE: The study objectives were to define subcutaneous (s.c.) interferon gamma (IFN-gamma) disposition in patients with gastrointestinal malignancies receiving 5-fluorouracil (5-FU) and leucovorin (LV) and to examine the relationship between IFN-gamma exposures and Fas upregulation in vivo and in vitro. Leucovorin 189-199 interferon gamma Homo sapiens 65-92 14648016-1 2004 PURPOSE: The study objectives were to define subcutaneous (s.c.) interferon gamma (IFN-gamma) disposition in patients with gastrointestinal malignancies receiving 5-fluorouracil (5-FU) and leucovorin (LV) and to examine the relationship between IFN-gamma exposures and Fas upregulation in vivo and in vitro. Leucovorin 189-199 interferon gamma Homo sapiens 83-92 14648016-2 2004 METHODS: Patients received IFN-gamma (10, 25, 50, 75, and 100 microg/m(2)) with LV and 5-FU, and serial samples were collected after the first dose. Fluorouracil 87-91 interferon gamma Homo sapiens 27-36 14648016-9 2004 In vitro studies in HT29 cells demonstrated that clinically relevant IFN-gamma concentrations (1 to 10 U/ml for 6.5 h) with 5-FU/LV upregulated Fas expression 3.5-fold, similar to that in PBMC in vivo. Fluorouracil 124-128 interferon gamma Homo sapiens 69-78 14648016-11 2004 Our results showed that IFN-gamma upregulates Fas in PBMC in vivo and in HT29 cells in vitro at tolerable, clinically relevant exposures and that monitoring IFN-gamma pharmacokinetics/pharmacodynamics may be warranted in IFN-gamma clinical use. ammonium ferrous sulfate 46-49 interferon gamma Homo sapiens 24-33 14648016-11 2004 Our results showed that IFN-gamma upregulates Fas in PBMC in vivo and in HT29 cells in vitro at tolerable, clinically relevant exposures and that monitoring IFN-gamma pharmacokinetics/pharmacodynamics may be warranted in IFN-gamma clinical use. ammonium ferrous sulfate 46-49 interferon gamma Homo sapiens 157-166 14648016-11 2004 Our results showed that IFN-gamma upregulates Fas in PBMC in vivo and in HT29 cells in vitro at tolerable, clinically relevant exposures and that monitoring IFN-gamma pharmacokinetics/pharmacodynamics may be warranted in IFN-gamma clinical use. ammonium ferrous sulfate 46-49 interferon gamma Homo sapiens 157-166 15203316-4 2004 Production by PBMCs of IL-12 and IFN-gamma was significantly higher and production of IL-4 was significantly lower after stimulation with Der f allergen in RIT-treated patients than in control patients. Ritonavir 156-159 interferon gamma Homo sapiens 33-42 15203316-5 2004 Significant increases in the expression of IL-12R beta2 chain before and after stimulation of CD4(+) T cells with IL-12 or IFN-gamma were observed in RIT-treated patients compared with that in control patients. Ritonavir 150-153 interferon gamma Homo sapiens 123-132 15005728-13 2004 In atopic patients with the C-to-U conversion, PBMCs faintly showed the tyrosine phosphorylation of Stat4, and the IgE production by PBMCs was not suppressed by IL-12 whereas it was suppressed by IFN-gamma. Tyrosine 72-80 interferon gamma Homo sapiens 196-205 15005730-6 2004 The numbers of IFN-gamma-, IL-4- and IL-12-producing CBMC were counted for each stimulation. cbmc 53-57 interferon gamma Homo sapiens 15-24 15005730-11 2004 Children who had atopic eczema/dermatitis syndrome (AEDS) during the observation (n=53) had significantly lower numbers of IFN-gamma-producing CBMC after stimulation with OVA and cat than their non-AEDS counterparts. cbmc 143-147 interferon gamma Homo sapiens 123-132 15005730-12 2004 CONCLUSIONS: Although the numbers of infants in our study are limited our data suggest that a low number of IL-12-producing CBMC is associated with IgE sensitization during early childhood and that a reduced number of IFN-gamma-producing CBMC promotes the development of AEDS during the first 2 years of life. cbmc 238-242 interferon gamma Homo sapiens 218-227 14972774-7 2004 Asbestos exposure, regardless of type, up-regulated a TH1 lymphocyte-derived cytokine, interferon gamma (IFNgamma), and the TH2 lymphocyte-derived cytokines interleukin-4 (IL-4) and interleukin-13 (IL-13). Asbestos 0-8 interferon gamma Homo sapiens 87-103 14972774-7 2004 Asbestos exposure, regardless of type, up-regulated a TH1 lymphocyte-derived cytokine, interferon gamma (IFNgamma), and the TH2 lymphocyte-derived cytokines interleukin-4 (IL-4) and interleukin-13 (IL-13). Asbestos 0-8 interferon gamma Homo sapiens 105-113 14988837-9 2004 In contrast, anti-CD3/ICOS-stimulated-LPMC from CD secreted significantly increased amounts of interferon (IFN)-gamma in the presence of IL-12. lpmc 38-42 interferon gamma Homo sapiens 95-117 14991615-7 2004 Furthermore, we showed that caps-PS induce production of IL-4, IL-6, IL-10, and IFN-gamma, and that this enhanced production was inhibited by blocking the CD40-CD40L interaction. caps-ps 28-35 interferon gamma Homo sapiens 80-89 14988821-10 2004 Blocking Smad7 with antisense oligonucleotides restored TGF-beta 1 signaling in biopsy specimens from Hp-infected patients and concomitantly reduced interferon-gamma and T-bet. Oligonucleotides 30-46 interferon gamma Homo sapiens 149-165 15009430-0 2004 Prostaglandin E2 is a potent regulator of interleukin-12- and interleukin-18-induced natural killer cell interferon-gamma synthesis. Dinoprostone 0-16 interferon gamma Homo sapiens 105-121 15009430-2 2004 However, other temporal events are likely to regulate such processes and as prostaglandin E2 (PGE2) is ubiquitous during inflammation this study tested the hypothesis that PGE2 was capable of directly modulating cytokine-induced NK cell IFN-gamma synthesis in the absence of other immune cells. Dinoprostone 76-92 interferon gamma Homo sapiens 237-246 15009430-5 2004 The selective EP2 receptor agonist butaprost, but not the EP1/EP3 agonist sulprostone, suppressed IFN-gamma synthesis and exclusively competed with PGE2 for receptor binding on NK cells. butaprost 35-44 interferon gamma Homo sapiens 98-107 15009430-2 2004 However, other temporal events are likely to regulate such processes and as prostaglandin E2 (PGE2) is ubiquitous during inflammation this study tested the hypothesis that PGE2 was capable of directly modulating cytokine-induced NK cell IFN-gamma synthesis in the absence of other immune cells. Dinoprostone 94-98 interferon gamma Homo sapiens 237-246 15009430-7 2004 The absence of demonstrable receptor modulation coupled with the observed suppression of IFN-gamma synthesis by both EP2 receptor-selective agonists and IBMX suggest that PGE2 acts directly on NK cells via EP2 receptors with its downstream effects on cAMP metabolism. Dinoprostone 171-175 interferon gamma Homo sapiens 89-98 15009430-9 2004 The ability of PGE2 to antagonize the potent inductive signal provided by the combination of IL-12 and IL-18 supports the concept that PGE2 may play an important role in limiting innate inflammatory processes in vivo through direct suppression of NK cell IFN-gamma synthesis. Dinoprostone 15-19 interferon gamma Homo sapiens 255-264 15009430-2 2004 However, other temporal events are likely to regulate such processes and as prostaglandin E2 (PGE2) is ubiquitous during inflammation this study tested the hypothesis that PGE2 was capable of directly modulating cytokine-induced NK cell IFN-gamma synthesis in the absence of other immune cells. Dinoprostone 172-176 interferon gamma Homo sapiens 237-246 15009430-9 2004 The ability of PGE2 to antagonize the potent inductive signal provided by the combination of IL-12 and IL-18 supports the concept that PGE2 may play an important role in limiting innate inflammatory processes in vivo through direct suppression of NK cell IFN-gamma synthesis. Dinoprostone 135-139 interferon gamma Homo sapiens 255-264 15009430-3 2004 Using homogeneous NK cell lines to establish direct effects, PGE2 (0.1-1 micro m) was found to suppress NK cell IFN-gamma synthesis and antagonized the potent synergistic IFN-gamma-inducing effects of IL-12 and IL-18. Dinoprostone 61-65 interferon gamma Homo sapiens 112-121 15009430-3 2004 Using homogeneous NK cell lines to establish direct effects, PGE2 (0.1-1 micro m) was found to suppress NK cell IFN-gamma synthesis and antagonized the potent synergistic IFN-gamma-inducing effects of IL-12 and IL-18. Dinoprostone 61-65 interferon gamma Homo sapiens 171-180 14657213-4 2004 PIO, ciglitazone, and GW347845 suppressed PHA-induced T cell proliferation by 40-50% and secretion of interferon-gamma and tumor necrosis factor alpha, by 30-50%. Pioglitazone 0-3 interferon gamma Homo sapiens 102-150 14657213-4 2004 PIO, ciglitazone, and GW347845 suppressed PHA-induced T cell proliferation by 40-50% and secretion of interferon-gamma and tumor necrosis factor alpha, by 30-50%. ciglitazone 5-16 interferon gamma Homo sapiens 102-150 14657213-4 2004 PIO, ciglitazone, and GW347845 suppressed PHA-induced T cell proliferation by 40-50% and secretion of interferon-gamma and tumor necrosis factor alpha, by 30-50%. GW 7845 22-30 interferon gamma Homo sapiens 102-150 15072464-2 2004 In this study, we investigated the molecular mechanisms of the resistance to Fas-mediated apoptosis and sensitization to Fas-induced cell death by IFN-gamma in human astrocytoma cells. ammonium ferrous sulfate 121-124 interferon gamma Homo sapiens 147-156 15072464-7 2004 Interestingly, caspase-1 protein expression but not that of caspase-3 nor -8 was up-regulated by IFN-gamma only in Fas-sensitive CRT-J cells but not in Fas-resistant U373-MG cells. ammonium ferrous sulfate 115-118 interferon gamma Homo sapiens 97-106 15072464-8 2004 These results collectively suggest that caspase-1, along with caspases-3 and -8, mediate Fas-induced cell death in human astrocytoma cells, and post-transcriptional regulation of caspase-1 may determine the responsiveness to IFN-gamma-induced sensitization to Fas-mediated apoptosis. ammonium ferrous sulfate 89-92 interferon gamma Homo sapiens 225-234 14994387-4 2004 IFN-gamma and IL-4 production by CD4+ T cells stimulated with phorbol myristate acetate (PMA) and calcium ionophore A23187 was measured by intracellular cytokine staining and flow cytometry. Tetradecanoylphorbol Acetate 62-87 interferon gamma Homo sapiens 0-9 14994387-4 2004 IFN-gamma and IL-4 production by CD4+ T cells stimulated with phorbol myristate acetate (PMA) and calcium ionophore A23187 was measured by intracellular cytokine staining and flow cytometry. Tetradecanoylphorbol Acetate 89-92 interferon gamma Homo sapiens 0-9 14994387-4 2004 IFN-gamma and IL-4 production by CD4+ T cells stimulated with phorbol myristate acetate (PMA) and calcium ionophore A23187 was measured by intracellular cytokine staining and flow cytometry. Calcium 98-105 interferon gamma Homo sapiens 0-9 14994387-4 2004 IFN-gamma and IL-4 production by CD4+ T cells stimulated with phorbol myristate acetate (PMA) and calcium ionophore A23187 was measured by intracellular cytokine staining and flow cytometry. Calcimycin 116-122 interferon gamma Homo sapiens 0-9 14994387-11 2004 PMA and A23187-activated ST CD4+ T cells mostly expressed IL-18Ralpha and produced high levels of IFN-gamma. Calcimycin 8-14 interferon gamma Homo sapiens 98-107 14978237-2 2004 The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2. Staurosporine 230-243 interferon gamma Homo sapiens 100-116 14767008-5 2004 Although interleukin (IL)-12 production of DC was impaired, they did not promote Th2 development as T cells activated by tacrolimus-treated DC produced less interferon (IFN)-gamma, IL-4 and IL-10. Tacrolimus 121-131 interferon gamma Homo sapiens 157-179 14978237-2 2004 The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2. Staurosporine 230-243 interferon gamma Homo sapiens 118-127 14978237-2 2004 The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2. herbimycin 275-285 interferon gamma Homo sapiens 100-116 15162834-8 2004 The addition of IL-18 to PHA or BLG stimulated CBMC significantly enhanced the IFN-gamma release (PHA: 6154; PHA + IL-18: 13474, p = 0.0001; BLG: 801; BLG + IL-18: 1077, p = 0.008). cbmc 47-51 interferon gamma Homo sapiens 79-88 14978237-2 2004 The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2. herbimycin 275-285 interferon gamma Homo sapiens 118-127 14978237-4 2004 Tyrosine phosphorylation of Janus kinases (JAK) 1/2 was induced by IFN-gamma but not by TPA. Tyrosine 0-8 interferon gamma Homo sapiens 67-76 14978237-6 2004 IFN-gamma-induced tyrosine phosphorylation of phospholipase C (PLC)-gamma was inhibited by AG 490 (a JAK inhibitor), and the association between JAK1/2 and PLC-gamma was increased after IFN-gamma treatment, indicating the activation of PLC-gamma via JAK1/2 phosphorylation. Tyrosine 18-26 interferon gamma Homo sapiens 0-9 14978237-6 2004 IFN-gamma-induced tyrosine phosphorylation of phospholipase C (PLC)-gamma was inhibited by AG 490 (a JAK inhibitor), and the association between JAK1/2 and PLC-gamma was increased after IFN-gamma treatment, indicating the activation of PLC-gamma via JAK1/2 phosphorylation. Tyrosine 18-26 interferon gamma Homo sapiens 186-195 14960298-0 2004 High nitric oxide production in autistic disorder: a possible role for interferon-gamma. Nitric Oxide 5-17 interferon gamma Homo sapiens 71-87 14980480-7 2004 These Gag-specific IELs expressed the activation marker CD69 and produced IFN-gamma, suggesting an active immune response in this locale. Glycosaminoglycans 6-9 interferon gamma Homo sapiens 74-83 14525787-6 2004 Equivalent amounts of interferon-gamma (IFN-gamma) were secreted following coculture with GPI-negative and GPI-positive targets. Glycosylphosphatidylinositols 90-93 interferon gamma Homo sapiens 22-38 14525787-6 2004 Equivalent amounts of interferon-gamma (IFN-gamma) were secreted following coculture with GPI-negative and GPI-positive targets. Glycosylphosphatidylinositols 90-93 interferon gamma Homo sapiens 40-49 14525787-6 2004 Equivalent amounts of interferon-gamma (IFN-gamma) were secreted following coculture with GPI-negative and GPI-positive targets. Glycosylphosphatidylinositols 107-110 interferon gamma Homo sapiens 22-38 14525787-6 2004 Equivalent amounts of interferon-gamma (IFN-gamma) were secreted following coculture with GPI-negative and GPI-positive targets. Glycosylphosphatidylinositols 107-110 interferon gamma Homo sapiens 40-49 14967480-3 2004 Kynurenine production by MDA-MB-231 cells, which was taken as a measure of enzyme activity, was markedly stimulated by interferon-gamma (1000 units/ml). Kynurenine 0-10 interferon gamma Homo sapiens 119-135 14967480-4 2004 Accordingly, L-tryptophan utilization by MDA-MB-231 cells was enhanced by interferon-gamma. Tryptophan 13-25 interferon gamma Homo sapiens 74-90 14967480-5 2004 1-Methyl-DL-tryptophan (1 mM) inhibited interferon-gamma induced kynurenine production by MBA-MB-231 cells. 1-methyltryptophan 0-22 interferon gamma Homo sapiens 40-56 14967480-5 2004 1-Methyl-DL-tryptophan (1 mM) inhibited interferon-gamma induced kynurenine production by MBA-MB-231 cells. Kynurenine 65-75 interferon gamma Homo sapiens 40-56 14967480-6 2004 Kynurenine production by MCF-7 cells remained at basal levels when cultured in the presence of interferon-gamma. Kynurenine 0-10 interferon gamma Homo sapiens 95-111 14623896-4 2004 STAT1C was found to be tyrosine-phosphorylated in the nucleus for more than 30 h after IFN-gamma stimulation. Tyrosine 23-31 interferon gamma Homo sapiens 87-96 14623896-7 2004 Studies with cycloheximide treatment showed that protein synthesis induced in the first 24 h after IFN-gamma treatment was required for apoptosis under these conditions. Cycloheximide 13-26 interferon gamma Homo sapiens 99-108 14974940-6 2004 Sodium salicylate administration reduced IL-1beta and IFN-gamma mRNA in both small-for-size and whole allografts, but it could decrease IL-2 and IL-10 mRNA levels only in small-for-size allografts. Sodium Salicylate 0-17 interferon gamma Homo sapiens 54-63 14966405-4 2004 METHODS: Expression of NFAT (nuclear factor of activated T cells)-regulated genes (interleukin 2, interferon-gamma, and granulocyte-macrophage colony-stimulating factor) in phorbol myristate acetate/ionomycin-stimulated peripheral blood from healthy volunteers (n=34) and from stable renal (n=25), cardiac (n=26), and liver (n=14) transplant recipients receiving CsA therapy was measured by quantitative real-time reverse transcriptase-polymerase chain reaction before and 2 hr after drug intake. Acetates 191-198 interferon gamma Homo sapiens 98-168 14966405-4 2004 METHODS: Expression of NFAT (nuclear factor of activated T cells)-regulated genes (interleukin 2, interferon-gamma, and granulocyte-macrophage colony-stimulating factor) in phorbol myristate acetate/ionomycin-stimulated peripheral blood from healthy volunteers (n=34) and from stable renal (n=25), cardiac (n=26), and liver (n=14) transplant recipients receiving CsA therapy was measured by quantitative real-time reverse transcriptase-polymerase chain reaction before and 2 hr after drug intake. Ionomycin 199-208 interferon gamma Homo sapiens 98-168 14966405-6 2004 RESULTS: Two hours after oral CsA ingestion, the mean suppression of induced interleukin 2, interferon-gamma, and granulocyte-macrophage colony-stimulating factor gene expression was 85%. Cyclosporine 30-33 interferon gamma Homo sapiens 92-162 15037205-2 2004 IFN-gamma induced accumulation of ROS and activation of JNK and p38 in HSC536/N and PD149L but not in HSC99 cells. Reactive Oxygen Species 34-37 interferon gamma Homo sapiens 0-9 16212923-9 2004 TTMP could enhance supernatant concentration and gene expression levels of IFN-gamma, IL-2 and T-bet, but reduce those of type 2 cytokines. tetramethylpyrazine 0-4 interferon gamma Homo sapiens 75-84 14962250-4 2004 In macrophages, IFN-gamma strongly induces indoleamine (2,3)-dioxygenase, an enzyme which degrades tryptophan (trp) to kynurenine (kyn). Tryptophan 99-109 interferon gamma Homo sapiens 16-25 14962250-4 2004 In macrophages, IFN-gamma strongly induces indoleamine (2,3)-dioxygenase, an enzyme which degrades tryptophan (trp) to kynurenine (kyn). Tryptophan 111-114 interferon gamma Homo sapiens 16-25 14962250-4 2004 In macrophages, IFN-gamma strongly induces indoleamine (2,3)-dioxygenase, an enzyme which degrades tryptophan (trp) to kynurenine (kyn). Kynurenine 119-129 interferon gamma Homo sapiens 16-25 14962250-4 2004 In macrophages, IFN-gamma strongly induces indoleamine (2,3)-dioxygenase, an enzyme which degrades tryptophan (trp) to kynurenine (kyn). Kynurenine 119-122 interferon gamma Homo sapiens 16-25 14975243-3 2004 In contrast, secretion of other chemokines and interferon-gamma by these cells was sensitive to cycloheximide and detectable only after a lag. Cycloheximide 96-109 interferon gamma Homo sapiens 47-63 14734606-5 2004 When stimulated with the specific glycolipid ligand, alpha-galactosylceramide, peripheral blood V(alpha)24 NKT cells from patients with non-remitting disease produced significantly less IFN-gamma than those from healthy volunteers, but normal levels of IL-4. Glycolipids 34-44 interferon gamma Homo sapiens 186-195 14734606-5 2004 When stimulated with the specific glycolipid ligand, alpha-galactosylceramide, peripheral blood V(alpha)24 NKT cells from patients with non-remitting disease produced significantly less IFN-gamma than those from healthy volunteers, but normal levels of IL-4. alpha-galactosylceramide 53-77 interferon gamma Homo sapiens 186-195 14734609-2 2004 Stimulation via their invariant Valpha14 receptor with anti-CD3 or a ligand, alpha-galactosylceramide (alpha-GalCer), triggers activation of Valpha14 NKT cells, resulting in a rapid cytokine production such as IFN-gamma and IL-4. alpha-galactosylceramide 77-101 interferon gamma Homo sapiens 210-219 15106733-4 2004 Salicylate treatment inhibited COX-2 expression induced by TNF-alpha/IFN-gamma and regulated the activation of ERK, IKK and IkappaB degradation and subsequent NF-kappaB activation in MC3T3E1 osteoblasts. Salicylates 0-10 interferon gamma Homo sapiens 69-78 15072225-0 2004 Heparin inhibits IFN-gamma-induced fractalkine/CX3CL1 expression in human endothelial cells. Heparin 0-7 interferon gamma Homo sapiens 17-26 15072225-6 2004 The IFN-gamma-induced expressions of fractalkine mRNA and protein were inhibited by heparin in a concentration-dependent manner. Heparin 84-91 interferon gamma Homo sapiens 4-13 15072225-7 2004 Heparin also inhibited adhesion of mononuclear cells (MNC) to HUVEC monolayers stimulated with IFN-gamma, but it did not inhibit the MNC adhesion to the monolayers stimulated with interleukin-1beta. Heparin 0-7 interferon gamma Homo sapiens 95-104 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 56-63 interferon gamma Homo sapiens 67-76 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 56-63 interferon gamma Homo sapiens 133-142 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 56-63 interferon gamma Homo sapiens 133-142 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 56-63 interferon gamma Homo sapiens 133-142 15106733-7 2004 In addition, TNF-alpha/IFN-gamma stimulated ROS release in the osteoblasts. ros 44-47 interferon gamma Homo sapiens 23-32 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 81-88 interferon gamma Homo sapiens 133-142 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 81-88 interferon gamma Homo sapiens 133-142 14767438-5 2004 RESULTS: Nitric oxide measurements were related to inflammation and T(H)1/T(H)2 balance, that is, subepithelial eosinophilic infiltration and eosinophilic cationic protein and IFN-gamma/IL-4 ratio in bronchoalveolar lavage fluids. Nitric Oxide 9-21 interferon gamma Homo sapiens 176-185 15072225-8 2004 Electrophoretic analysis demonstrated direct binding of heparin to IFN-gamma and heparin was found to partially block the binding of IFN-gamma to IFN-gamma receptor (IFN-gamma R). Heparin 81-88 interferon gamma Homo sapiens 133-142 14742677-5 2004 Moreover, barbiturates suppressed the expression of a luciferase reporter gene under control of NFAT (stably transfected Jurkat T cells), and of the cytokine genes interleukin-2 and interferon-gamma that contain functional binding motifs for NFAT within their regulatory promotor domains (human peripheral blood CD3+ lymphocytes). Barbiturates 10-22 interferon gamma Homo sapiens 182-198 15078004-0 2004 Effect of multiple doses of clarithromycin and amoxicillin on IL-6, IFNgamma and IL-10 plasma levels in patients with community acquired pneumonia. Clarithromycin 28-42 interferon gamma Homo sapiens 68-76 15078004-7 2004 Clarithromycin significantly decreased plasma levels of IL-6 and significantly increased those of IFNgamma and IL-10 at the 3rd and 7th day in comparison to basal levels. Clarithromycin 0-14 interferon gamma Homo sapiens 98-106 14760948-0 2004 Multiple sclerosis: expression of CD1a and production of IL-12p70 and IFN-gamma by blood mononuclear cells in patients on combination therapy with IFN-beta and glatiramer acetate compared to monotherapy with IFN-beta. Glatiramer Acetate 160-178 interferon gamma Homo sapiens 70-79 15106878-7 2004 When compared with the original material, CLN obtained by this method shows (1) similar pattern of peptides in SDS PAGE, (2) identical amino acid analysis, characterized by high content of proline (22%), a high proportion of nonpolar amino acids, a low percentage of glycine, alanine, arginine, histidine, and no tryptophan, methionine, and cysteine residues, (3) similar pattern of HPLC profiles, and (4) its ability to induce IFN gamma and TNF alpha. colostrinine 42-45 interferon gamma Homo sapiens 428-437 14760090-3 2004 Ex vivo IFN-gamma cytokine flow cytometry analysis of postvaccine PBMCs after brief gp100(209-2M) in vitro activation showed that for all of the patients studied tetramer(+) CD8(+) T cells produced IFN-gamma; however, some patients had significant numbers of tetramer(+) IFN-gamma(-) CD8(+)T cells suggesting functional anergy. postvaccine 54-65 interferon gamma Homo sapiens 8-17 14630988-7 2004 In addition, the percentages of T cells secreting IFN-gamma after in vitro stimulation with phorbol myristate acetate and ionomycin was significantly higher in infected fetuses [10% (5-25)] than in healthy fetuses [0.8% (0.6-1.2)] with IFN-gamma being mostly secreted by CD8(+) T cells and to a lesser extend by CD4(+) T cells. Tetradecanoylphorbol Acetate 92-117 interferon gamma Homo sapiens 50-59 14630988-7 2004 In addition, the percentages of T cells secreting IFN-gamma after in vitro stimulation with phorbol myristate acetate and ionomycin was significantly higher in infected fetuses [10% (5-25)] than in healthy fetuses [0.8% (0.6-1.2)] with IFN-gamma being mostly secreted by CD8(+) T cells and to a lesser extend by CD4(+) T cells. Tetradecanoylphorbol Acetate 92-117 interferon gamma Homo sapiens 236-245 14630988-7 2004 In addition, the percentages of T cells secreting IFN-gamma after in vitro stimulation with phorbol myristate acetate and ionomycin was significantly higher in infected fetuses [10% (5-25)] than in healthy fetuses [0.8% (0.6-1.2)] with IFN-gamma being mostly secreted by CD8(+) T cells and to a lesser extend by CD4(+) T cells. Ionomycin 122-131 interferon gamma Homo sapiens 50-59 14630988-10 2004 Indeed, the number of T cells capable of secreting IFN-gamma is strikingly lower after in vitro stimulation with the CMV-specific antigen than after in vitro stimulation with phorbol myristate acetate/ionomycin that bypasses signaling through the T-cell receptor. Tetradecanoylphorbol Acetate 175-200 interferon gamma Homo sapiens 51-60 14630988-10 2004 Indeed, the number of T cells capable of secreting IFN-gamma is strikingly lower after in vitro stimulation with the CMV-specific antigen than after in vitro stimulation with phorbol myristate acetate/ionomycin that bypasses signaling through the T-cell receptor. Ionomycin 201-210 interferon gamma Homo sapiens 51-60 14687581-2 2004 Both IFN-gamma and IL-1 are known to increase the release of arachidonic acid (AA) from airway epithelial cells, suggesting that AA metabolites may mediate the cytokine-induced inflammation. Arachidonic Acid 61-77 interferon gamma Homo sapiens 5-14 14687581-4 2004 Treatment with IFN-gamma and IL-1alpha for 15 min induced a rapid increase of AA release from NHBE cells, which was blocked by the cPLA(2) inhibitor MAFP (p<0.05) but not by the sPLA(2) inhibitor LY311727 or iPLA(2) inhibitor HELSS. LY 311727 199-207 interferon gamma Homo sapiens 15-24 14687581-4 2004 Treatment with IFN-gamma and IL-1alpha for 15 min induced a rapid increase of AA release from NHBE cells, which was blocked by the cPLA(2) inhibitor MAFP (p<0.05) but not by the sPLA(2) inhibitor LY311727 or iPLA(2) inhibitor HELSS. ipla 211-215 interferon gamma Homo sapiens 15-24 14753769-8 2004 The HIC resin was firstly used for the purification and simultaneous renaturation of recombinant human interferon-gamma (rhIFN-gamma) in the extract solution containing 7.0 mol/l guanidine hydrochloride with only one step. Guanidine 179-202 interferon gamma Homo sapiens 103-119 14681912-0 2004 Dinucleotide repeat polymorphism in interferon-gamma gene is not associated with sporadic Alzheimer"s disease. Dinucleoside Phosphates 0-12 interferon gamma Homo sapiens 36-52 13680192-5 2004 Coculture of these DCs and ATs induced significant production of interleukin 12 (IL-12) and also enhanced the production of interferon gamma (IFN-gamma). ats 27-30 interferon gamma Homo sapiens 124-151 15053234-8 2004 IFN-gamma production was inhibited by haloperidol and chlorpromazine, but stimulated by clozapine. Haloperidol 38-49 interferon gamma Homo sapiens 0-9 15053234-8 2004 IFN-gamma production was inhibited by haloperidol and chlorpromazine, but stimulated by clozapine. Chlorpromazine 54-68 interferon gamma Homo sapiens 0-9 15053234-8 2004 IFN-gamma production was inhibited by haloperidol and chlorpromazine, but stimulated by clozapine. Clozapine 88-97 interferon gamma Homo sapiens 0-9 15675129-4 2004 Patients and controls were genotyped by molecular methods for the microsatellite dinucleotide (CA) repeat within the first intron of IFN-gamma gene. microsatellite dinucleotide 66-93 interferon gamma Homo sapiens 133-142 16734132-5 2004 Following specific antigen stimulation in vitro with TB bacilli, the PBMCs from patients with active and inactive TB produced significantly higher levels of IFN-gamma (433.15+/-119.80 and 420.64+/-131.52 respectively) than controls (241.2+/-119.74), (P< 0.001). tb bacilli 53-63 interferon gamma Homo sapiens 157-166 14992447-0 2004 Peripheral blood mononuclear cell DNA 6-thioguanine metabolite levels correlate with decreased interferon-gamma production in patients with Crohn"s disease on AZA therapy. Thioguanine 38-51 interferon gamma Homo sapiens 95-111 14992447-0 2004 Peripheral blood mononuclear cell DNA 6-thioguanine metabolite levels correlate with decreased interferon-gamma production in patients with Crohn"s disease on AZA therapy. Azathioprine 159-162 interferon gamma Homo sapiens 95-111 15055740-5 2004 Similarly, production of IL-2, IL-10 and IFNgamma was higher in the group of heroin addicts than in healthy controls. Heroin 77-83 interferon gamma Homo sapiens 41-49 15061649-1 2004 Human macrophages stimulated with interferon-gamma generate neopterin and 7,8-dihydroneopterin which interfere with reactive species involved in LDL oxidation. Neopterin 60-69 interferon gamma Homo sapiens 34-50 15061649-1 2004 Human macrophages stimulated with interferon-gamma generate neopterin and 7,8-dihydroneopterin which interfere with reactive species involved in LDL oxidation. 7,8-dihydroneopterin 74-94 interferon gamma Homo sapiens 34-50 15356845-12 2004 The effects of vitamin E-coated filter, in particular the recovery of reactive IFNgamma production by Th1 cells and the restriction of spontaneous IL-4 release by Th2 cells may have clinical importance. Vitamin E 15-24 interferon gamma Homo sapiens 79-87 14678201-6 2004 Over-expression of the IkappaBalpha-serine mutant also inhibited reporter gene expression in response to IL-4, TNF-alpha, IL-1beta, and in some cases IFN-gamma using constructs with sequences from the pIgR promoter. Serine 36-42 interferon gamma Homo sapiens 150-159 15481136-6 2004 Stimulation with tumor necrosis factor (TNF) and interferon-gamma (IFN-gamma) induced high and low expression of membrane-bound FKN on HUVEC and BMVEC, respectively, together with expression of VCAM-1 and intercellular adhesion molecule-1 (ICAM)-1. 3-[2-Chloro-5-(Methylsulfonyl)phenyl]-6-(2,4-Difluorophenoxy)-1h-Pyrazolo[3,4-D]pyrimidine 128-131 interferon gamma Homo sapiens 49-76 15481136-10 2004 These results demonstrate that stimulation with TNF and IFN-gamma triggers expression of membrane-bound FKN on both HUVEC and BMVEC, but prevents TEM of CD16+ monocytes in response to soluble FKN. 3-[2-Chloro-5-(Methylsulfonyl)phenyl]-6-(2,4-Difluorophenoxy)-1h-Pyrazolo[3,4-D]pyrimidine 104-107 interferon gamma Homo sapiens 56-65 15481136-10 2004 These results demonstrate that stimulation with TNF and IFN-gamma triggers expression of membrane-bound FKN on both HUVEC and BMVEC, but prevents TEM of CD16+ monocytes in response to soluble FKN. 3-[2-Chloro-5-(Methylsulfonyl)phenyl]-6-(2,4-Difluorophenoxy)-1h-Pyrazolo[3,4-D]pyrimidine 192-195 interferon gamma Homo sapiens 56-65 14688135-4 2004 Western blotting of whole-cell protein extracts revealed that infection with live, but not heat-killed, H. pylori time-dependently decreased IFN-gamma-induced STAT1 tyrosine phosphorylation. Tyrosine 165-173 interferon gamma Homo sapiens 141-150 15633589-7 2004 The percentage and number of interferon (IFN)-gamma+ T lymphocytes was decreased (P<0.05) at rest immediately after the ITP compared with before and following 2 weeks of resting recovery from the ITP. Inosine Triphosphate 123-126 interferon gamma Homo sapiens 29-51 15633589-7 2004 The percentage and number of interferon (IFN)-gamma+ T lymphocytes was decreased (P<0.05) at rest immediately after the ITP compared with before and following 2 weeks of resting recovery from the ITP. Inosine Triphosphate 199-202 interferon gamma Homo sapiens 29-51 14688315-5 2004 Inclusion of any of the costimulatory signaling regions in series with TCRzeta enhanced the level of specific Ag-induced IL-2, IFN-gamma, TNF-alpha, and GM-CSF cytokine production and enabled resting primary T cells to survive and proliferate in response to Ag in the absence of any exogenous factors. tcrzeta 71-78 interferon gamma Homo sapiens 127-136 14688319-6 2004 Furthermore, NK cells respond to poly(I:C) by producing proinflammatory cytokines like IL-6 and IL-8, as well as the antiviral cytokine IFN-gamma. poly 33-37 interferon gamma Homo sapiens 136-145 14688319-6 2004 Furthermore, NK cells respond to poly(I:C) by producing proinflammatory cytokines like IL-6 and IL-8, as well as the antiviral cytokine IFN-gamma. Iodine 38-39 interferon gamma Homo sapiens 136-145 14688363-5 2004 Interestingly, IL-23N220L, an N-glycosylation mutant showing reduced expression of excess p40 without changing the level of IL-23, exhibited a higher ratio of IFN-gamma- to IL-4-producing CD4(+) T cell frequency than did wild-type IL-23, suggesting a negative regulatory effect of p40 on Th1-prone immune response induced by IL-23. Nitrogen 20-21 interferon gamma Homo sapiens 159-168 15315353-2 2004 By using immunohistochemical SP method and pathological image system, the inhibitory effects of IFN-gamma on the expression of transforming growth factor beta receptor I in the in vitro cultured fibroblasts from Tenon"s capsule were quantitatively analyzed. TFF2 protein, human 29-31 interferon gamma Homo sapiens 96-105 14698862-0 2004 Cyclophosphamide modulates CD4+ T cells into a T helper type 2 phenotype and reverses increased IFN-gamma production of CD8+ T cells in secondary progressive multiple sclerosis. Cyclophosphamide 0-16 interferon gamma Homo sapiens 96-105 14964578-8 2004 The levels of CSF IL-6 and IFN-gamma in patients with non-herpetic ALE were significantly lower than those in patients with HSE (p<0.05 and p<0.01, respectively). Epinephrine 67-70 interferon gamma Homo sapiens 27-36 14964578-12 2004 The levels of IL-6 and IFN-gamma in the CSF of patients with non-herpetic ALE were significantly lower than those of patients with HSE, possibly reflecting an immunological process in this type of ALE rather than direct viral infection. Epinephrine 74-77 interferon gamma Homo sapiens 23-32 14964578-12 2004 The levels of IL-6 and IFN-gamma in the CSF of patients with non-herpetic ALE were significantly lower than those of patients with HSE, possibly reflecting an immunological process in this type of ALE rather than direct viral infection. Epinephrine 197-200 interferon gamma Homo sapiens 23-32 14698862-9 2004 We report here that in patients with secondary progressive MS, cyclophosphamide induces a marked increase in the percentage of CCR4(+) T cells that produce high levels of IL-4 and reverses the increase in the percentages of IFN-gamma-producing CCR5(+) and CXCR3(+) CD8(+) T cells. Cyclophosphamide 63-79 interferon gamma Homo sapiens 224-233 14698862-10 2004 Furthermore, therapy with cyclophosphamide increases IL-4-producing CD4(+) T cells and reverses the increase in IFN-gamma-producing CD8(+) T cells. Cyclophosphamide 26-42 interferon gamma Homo sapiens 112-121 15067204-4 2004 Intracellular staining of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) production in CD4+ lymphocytes after phorbol myristate acetate and ionomycin stimulation was performed at the same time points. Tetradecanoylphorbol Acetate 117-142 interferon gamma Homo sapiens 69-78 15215621-5 2004 Culture supernatant from AcEIL-18 infected cells showed a synergistic effect with recombinant human interleukin-12 for induction of interferon-gamma gene expression in equine peripheral mononuclear cells, indicating that the recombinant equine IL-18 expressed in this study also has biological activity without any treatment. aceil 25-30 interferon gamma Homo sapiens 132-148 15502882-8 2004 Physiologic concentrations of hemozoin or b-hematin suppressed LPS- and IFN-gamma-induced COX-2 mRNA in a time- and dose-dependent manner, resulting in decreased COX-2 protein and PGE(2) production. Prostaglandins E 180-183 interferon gamma Homo sapiens 72-81 15067204-4 2004 Intracellular staining of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) production in CD4+ lymphocytes after phorbol myristate acetate and ionomycin stimulation was performed at the same time points. Ionomycin 147-156 interferon gamma Homo sapiens 51-67 15067204-4 2004 Intracellular staining of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) production in CD4+ lymphocytes after phorbol myristate acetate and ionomycin stimulation was performed at the same time points. Ionomycin 147-156 interferon gamma Homo sapiens 69-78 15747831-7 2004 STAT1 activation upon IFNgamma influence is blocked by nocodazole, but does not depend on the activity of Src-family kinases. Nocodazole 55-65 interferon gamma Homo sapiens 22-30 15792026-5 2004 The intracellular expression of IL-4 and IFN-gamma in CD4+ or CD8+ cells after stimulation with ionomycin/PMA was estimated by flow cytometer (FACSCalibur, Becton Dickinson) and serum levels of both cytokines were assessed with ELISA (R & D Systems) in all subjects. Ionomycin 96-105 interferon gamma Homo sapiens 41-50 15792026-5 2004 The intracellular expression of IL-4 and IFN-gamma in CD4+ or CD8+ cells after stimulation with ionomycin/PMA was estimated by flow cytometer (FACSCalibur, Becton Dickinson) and serum levels of both cytokines were assessed with ELISA (R & D Systems) in all subjects. Tetradecanoylphorbol Acetate 106-109 interferon gamma Homo sapiens 41-50 14525998-6 2003 In the present study, we demonstrate that the post-translational processing (proteolysis and covalent dimerization) observed with cysteineless recombinant human interferon-gamma (rhIFN-gamma) is tightly associated with its in vivo glycation. cysteineless 130-142 interferon gamma Homo sapiens 161-177 14695155-2 2003 Importantly, the cytotoxic effects of thymidine deprivation induced by 5-fluorouracil (FUra) combined with leucovorin (LV) was enhanced by IFN-gamma, and the synergism was shown to be dependent on Fas, FUra-induced DNA damage, and independent of p53. Thymidine 38-47 interferon gamma Homo sapiens 139-148 14695155-2 2003 Importantly, the cytotoxic effects of thymidine deprivation induced by 5-fluorouracil (FUra) combined with leucovorin (LV) was enhanced by IFN-gamma, and the synergism was shown to be dependent on Fas, FUra-induced DNA damage, and independent of p53. Fluorouracil 71-85 interferon gamma Homo sapiens 139-148 14648593-5 2003 SB203580, a specific p38alpha and p38beta2 MAPK inhibitor, decreased the TRAIL expression induced by IFN-gamma. SB 203580 0-8 interferon gamma Homo sapiens 101-110 14695155-2 2003 Importantly, the cytotoxic effects of thymidine deprivation induced by 5-fluorouracil (FUra) combined with leucovorin (LV) was enhanced by IFN-gamma, and the synergism was shown to be dependent on Fas, FUra-induced DNA damage, and independent of p53. Fluorouracil 87-91 interferon gamma Homo sapiens 139-148 14695155-2 2003 Importantly, the cytotoxic effects of thymidine deprivation induced by 5-fluorouracil (FUra) combined with leucovorin (LV) was enhanced by IFN-gamma, and the synergism was shown to be dependent on Fas, FUra-induced DNA damage, and independent of p53. Leucovorin 107-117 interferon gamma Homo sapiens 139-148 14695155-2 2003 Importantly, the cytotoxic effects of thymidine deprivation induced by 5-fluorouracil (FUra) combined with leucovorin (LV) was enhanced by IFN-gamma, and the synergism was shown to be dependent on Fas, FUra-induced DNA damage, and independent of p53. Leucovorin 119-121 interferon gamma Homo sapiens 139-148 14695155-2 2003 Importantly, the cytotoxic effects of thymidine deprivation induced by 5-fluorouracil (FUra) combined with leucovorin (LV) was enhanced by IFN-gamma, and the synergism was shown to be dependent on Fas, FUra-induced DNA damage, and independent of p53. ammonium ferrous sulfate 197-200 interferon gamma Homo sapiens 139-148 14695155-2 2003 Importantly, the cytotoxic effects of thymidine deprivation induced by 5-fluorouracil (FUra) combined with leucovorin (LV) was enhanced by IFN-gamma, and the synergism was shown to be dependent on Fas, FUra-induced DNA damage, and independent of p53. Fluorouracil 202-206 interferon gamma Homo sapiens 139-148 14668793-7 2003 IFNgamma boosted As2O3-induced apoptosis in APL cells as tested by TUNEL, Annexin V staining and activation of caspase 3. Arsenic Trioxide 17-22 interferon gamma Homo sapiens 0-8 14668793-9 2003 Synergism by IFNgamma and arsenic on IRF-1 expression is mediated by a composite element in the IRF-1 promoter that includes an IFNgamma-activation site (GAS) overlapped by a nonconsensus site for nuclear factor kappa B (NFkappaB). Arsenic 26-33 interferon gamma Homo sapiens 128-136 14668793-0 2003 Arsenic enhances the activation of Stat1 by interferon gamma leading to synergistic expression of IRF-1. Arsenic 0-7 interferon gamma Homo sapiens 44-60 14668793-10 2003 Arsenic has no effect on NFkappaB, whereas it enhances the activation of Stat1 by IFNgamma in NB4 cells leading to an increase in IRF-1 expression. Arsenic 0-7 interferon gamma Homo sapiens 82-90 14604568-9 2003 At Week 12, the IFN-gamma response to MSP1 was substantially higher in the vaccine group where No SP had been given. fanasil, pyrimethamine drug combination 39-41 interferon gamma Homo sapiens 16-25 14645150-1 2003 Treatment of melanoma cell lines with IFN-gamma induces the switch from proteasome (PS) to immunoproteasome (iPS). IPS 109-112 interferon gamma Homo sapiens 38-47 14700442-4 2003 OBJECTIVE: To determine the effect of the TH2 environment with interferon-gamma (IFN-gamma) and heat shock protein 70 (HSP 70) on CD23 receptor expression and tumor necrosis factor alpha (TNF-alpha) production. th2 42-45 interferon gamma Homo sapiens 63-79 14700442-4 2003 OBJECTIVE: To determine the effect of the TH2 environment with interferon-gamma (IFN-gamma) and heat shock protein 70 (HSP 70) on CD23 receptor expression and tumor necrosis factor alpha (TNF-alpha) production. th2 42-45 interferon gamma Homo sapiens 81-90 14700442-11 2003 CONCLUSIONS: Both IFN-gamma and HSP 70, in the TH2 environment, up-regulate CD23 expression and thus may play an important role in maintaining the chronic inflammatory state in asthma. th2 47-50 interferon gamma Homo sapiens 18-27 14720463-6 2003 Human recombinant IFN gamma stimulated tyrosine phosphorylation of different members of STAT-like proteins (Signal Transducers and Activators of Transcription), as evaluated by Western blotting of hemocyte protein extracts with specific anti-phospho-STAT antibodies. Tyrosine 39-47 interferon gamma Homo sapiens 18-27 14704034-4 2003 Treating ECFCs with a high concentration of Ly294002 (50 micromol/L) in the presence of EPO and/or IFN-gamma reduced cell viability by inducing apoptosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 44-52 interferon gamma Homo sapiens 99-108 14704034-6 2003 Adding IFN-gamma or EPO induced Bcl-x expression in ECFCs, as determined by Western blotting, and expression was suppressed in the presence of Ly294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 143-151 interferon gamma Homo sapiens 7-16 14615474-6 2003 Interferon gamma (IFNgamma) production inversely correlated with change in ERMBT (correlation coefficient = -0.614; p < 0.02), although the overall change in ERMBT was not statistically significant (mean = -4%; p = 0.28). ermbt 75-80 interferon gamma Homo sapiens 0-16 14615474-6 2003 Interferon gamma (IFNgamma) production inversely correlated with change in ERMBT (correlation coefficient = -0.614; p < 0.02), although the overall change in ERMBT was not statistically significant (mean = -4%; p = 0.28). ermbt 75-80 interferon gamma Homo sapiens 18-26 14615474-7 2003 The IFNgamma production correlates with change in ERMBT. ermbt 50-55 interferon gamma Homo sapiens 4-12 14645150-7 2003 Immunoblotting analysis revealed that while IFN-gamma was able to consistently induce the switch from PS to iPS, IFN-alpha treatment did not, possibly due to post-transcriptional event(s) blocking the expression of iPS-specific subunits. IPS 108-111 interferon gamma Homo sapiens 44-53 14645150-7 2003 Immunoblotting analysis revealed that while IFN-gamma was able to consistently induce the switch from PS to iPS, IFN-alpha treatment did not, possibly due to post-transcriptional event(s) blocking the expression of iPS-specific subunits. IPS 215-218 interferon gamma Homo sapiens 44-53 14644034-0 2003 Tissue expression of inducible nitric oxide synthase requires IFN-gamma production by infiltrating splenic T cells: more evidence for immunosuppression by nitric oxide. Nitric Oxide 31-43 interferon gamma Homo sapiens 62-71 14561849-8 2003 Moreover, PGE1 inhibited the production of IL-12 and interferon-gamma in PBMC in the presence and absence of IL-18, whereas PGE1 induced IL-10 production. Alprostadil 10-14 interferon gamma Homo sapiens 53-69 14644623-6 2003 Our results revealed that low concentrations (1-10 microg/ml) of gallium promoted cells to enter the S phase of cell cycle and enhanced cellular release of tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma, both in vitro and in vivo. Gallium 65-72 interferon gamma Homo sapiens 208-224 14769148-4 2003 The rates of transcription of many of the genes encoding these RNAs are enhanced by IFN-gamma-mediated activation of the Stat1 transcription factor that is tyrosine phosphorylated and translocates to the nucleus, where it binds enhancers present in IFN-stimulated genes (ISGs). Tyrosine 156-164 interferon gamma Homo sapiens 84-93 14769148-8 2003 Using actinomycin D as a transcriptional inhibitor, we show that the mRNA half-life is rapidly shortened by IFN-gamma. Dactinomycin 6-19 interferon gamma Homo sapiens 108-117 14769150-5 2003 IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. Superoxides 85-95 interferon gamma Homo sapiens 0-9 14769150-5 2003 IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. Butyric Acid 171-183 interferon gamma Homo sapiens 0-9 14659507-3 2003 Treatment of cultured dorsal horn neurons with IFN-gamma for 2 weeks resulted in a significantly reduced clustering of alpha-amino-3-hydroxy-5-methylisoxazole (AMPA) receptor subunit 1 (GluR1) that was dependent on nitric oxide. alpha-amino-3-hydroxy-5-methylisoxazole 119-158 interferon gamma Homo sapiens 47-56 14659507-3 2003 Treatment of cultured dorsal horn neurons with IFN-gamma for 2 weeks resulted in a significantly reduced clustering of alpha-amino-3-hydroxy-5-methylisoxazole (AMPA) receptor subunit 1 (GluR1) that was dependent on nitric oxide. Nitric Oxide 215-227 interferon gamma Homo sapiens 47-56 14659507-8 2003 Since GluR1-containing AMPA receptors (AMPARs) occur predominantly on inhibitory neurons in the dorsal horn, we suggest that the IFN-gamma-mediated increase in spontaneous activity and responsiveness to DRG axon stimulation, decrease in sensitivity to PTX and tendency for EPSC bursting result from a reduced expression of GluR1 on these neurons and not from a reduction in active GABA(A) receptors in the network. Picrotoxin 252-255 interferon gamma Homo sapiens 129-138 14761645-7 2003 The levels of IL-4, IL-6, TNF-alpha and IFN-gamma in the exudation fluid during the rejection of xeno-ADM were obviously higher than those in the blood of the patients as determined by ELISA, while the serum levels of IL-4 and IFN-gamma in xeno-ADM group were lower and higher than those in xeno-ADM when without rejection respectively. xeno-adm 97-105 interferon gamma Homo sapiens 40-49 14761645-8 2003 The serum levels of IL-4, TNF-alpha and IFN-gamma in xeno-ADM group were significantly higher than those in allo-ADM and auto-TTS groups (P < 0.05 - 0.01). xeno-adm 53-61 interferon gamma Homo sapiens 40-49 12975380-4 2003 Using a murine osteoclast precursor cell line as well as primary human osteoclast precursors, we demonstrate that pharmacologic levels of two PIs that are linked clinically to osteopenia, ritonavir and saquinavir, abrogate a physiological block to RANKL activity, interferon-gamma-mediated degradation of the RANKL signaling adapter protein, TRAF6 (tumor necrosis factor receptor-associated protein 6) in proteasomes. Monothiopyrophosphoric acid 142-145 interferon gamma Homo sapiens 264-280 12975380-4 2003 Using a murine osteoclast precursor cell line as well as primary human osteoclast precursors, we demonstrate that pharmacologic levels of two PIs that are linked clinically to osteopenia, ritonavir and saquinavir, abrogate a physiological block to RANKL activity, interferon-gamma-mediated degradation of the RANKL signaling adapter protein, TRAF6 (tumor necrosis factor receptor-associated protein 6) in proteasomes. Saquinavir 202-212 interferon gamma Homo sapiens 264-280 14769228-7 2003 The IL-1, TNF-alpha and IFN-gamma were found in supernatant of OFs treated by patients" serum. ofs 63-66 interferon gamma Homo sapiens 24-33 14682409-4 2003 RESULTS: The pleural fluid Levels of IL-6, TNF-alpha and IFN-gamma in TB patients were significantly higher than those with non-TB effusions (P values of <0.001, 0.018 and <0.001, respectively by independent t-test). Terbium 70-72 interferon gamma Homo sapiens 57-66 14607909-4 2003 To determine the effect of thiols on the production of IFN-gamma and IL-4 by splenocytes, cells were incubated in the presence and the absence of N-acetylcysteine (NAC) and stimulated with alphaCD3 or alphaCD3 and IL-12. Sulfhydryl Compounds 27-33 interferon gamma Homo sapiens 55-64 12855564-5 2003 Treatment of DCs with 4-OH-IF significantly reduced their ability to stimulate allogeneic T-cell proliferation and interferon-gamma (IFN-gamma) production. 4-oh 22-26 interferon gamma Homo sapiens 115-131 12855564-5 2003 Treatment of DCs with 4-OH-IF significantly reduced their ability to stimulate allogeneic T-cell proliferation and interferon-gamma (IFN-gamma) production. 4-oh 22-26 interferon gamma Homo sapiens 133-142 12855564-6 2003 Ifosfamide also decreased DC interleukin-12p70 (IL-12p70) production after stimulation with lipopolysaccharide (LPS) and IFN-gamma. Ifosfamide 0-10 interferon gamma Homo sapiens 121-130 12855564-7 2003 The decrease in allostimulatory capacity and in IFN-gamma and IL-12 production correlated with a decrease in intracellular GSH in the DCs. Glutathione 123-126 interferon gamma Homo sapiens 48-57 14607949-4 2003 IFN-gamma-primed, mycobacteria-infected macrophages from wild-type individuals were incubated with ATP and this induced apoptosis and reduced mycobacterial viability by 90%. Adenosine Triphosphate 99-102 interferon gamma Homo sapiens 0-9 14571181-4 2003 Gag p24-specific and total Vbeta+ CD4 cells that expressed MIP-1beta, IFN-gamma and IL-2 were enumerated by intracytoplasmic cytokine staining. Glycosaminoglycans 0-3 interferon gamma Homo sapiens 70-79 14607909-5 2003 Augmenting intracellular soluble thiol pools ( approximately 2-fold) with 15 mM NAC blocked induction of IFN-gamma and increased production of IL-4 without causing significant changes in intracellular glutathione levels. Sulfhydryl Compounds 33-38 interferon gamma Homo sapiens 105-114 14607909-5 2003 Augmenting intracellular soluble thiol pools ( approximately 2-fold) with 15 mM NAC blocked induction of IFN-gamma and increased production of IL-4 without causing significant changes in intracellular glutathione levels. Acetylcysteine 80-83 interferon gamma Homo sapiens 105-114 14607909-9 2003 These studies suggest that increasing intracellular reduced thiol pools decreases IL-12 signaling and IFN-gamma production, while increasing IL-4 production. Sulfhydryl Compounds 60-65 interferon gamma Homo sapiens 102-111 14578196-0 2003 Interferon-gamma increases hPepT1-mediated uptake of di-tripeptides including the bacterial tripeptide fMLP in polarized intestinal epithelia. di-tripeptides 53-67 interferon gamma Homo sapiens 0-16 12928311-5 2003 RV16-induced IFN-gamma production correlated significantly with the methacholine PD (r = 0.50, p = 0.03), and the ratio of RV16-induced IFN-gamma:IL-5 correlated with % predicted FEV1 (r = 0.53, p = 0.02). rv16 0-4 interferon gamma Homo sapiens 13-22 12928311-5 2003 RV16-induced IFN-gamma production correlated significantly with the methacholine PD (r = 0.50, p = 0.03), and the ratio of RV16-induced IFN-gamma:IL-5 correlated with % predicted FEV1 (r = 0.53, p = 0.02). rv16 123-127 interferon gamma Homo sapiens 136-145 14578196-0 2003 Interferon-gamma increases hPepT1-mediated uptake of di-tripeptides including the bacterial tripeptide fMLP in polarized intestinal epithelia. tripeptide K-26 56-66 interferon gamma Homo sapiens 0-16 14578196-5 2003 We suggest that interferon-gamma could increase the hPepT1 mediated di-tripeptides uptake in inflamed epithelial cells. di-tripeptides 68-82 interferon gamma Homo sapiens 16-32 14578196-6 2003 Under these conditions, interferon-gamma will increase the intracellular amount of such diverse prokaryotic and eucaryotic small di-tripeptides in inflamed epithelial cells. di-tripeptides 129-143 interferon gamma Homo sapiens 24-40 14578204-3 2003 During CaM antagonist-mediated apoptosis in IFN-gamma-pretreated Fas-low cells, cleavage of caspases-8, -9, and -3 and Bid, release of cytochrome c from the mitochondria and an increase in the free cytosolic calcium concentration were observed. Calcium 208-215 interferon gamma Homo sapiens 44-53 14692429-9 2003 CONCLUSIONS: Amphotericin B induces the production of TNF-alpha, interferon-gamma, and IL-1beta, which may potentiate its toxic effects. Amphotericin B 13-27 interferon gamma Homo sapiens 65-81 14597879-6 2003 In contrast, only DC that had been taken up 5-FU- or LAK-treated tumors up-modulated IL-12 and presented tumor-associated antigens with increased efficiency, as shown by class I MHC-restricted interferon-gamma release and cytotoxic responses by autologous lymphocytes. Fluorouracil 44-48 interferon gamma Homo sapiens 193-209 14530214-5 2003 Capsaicin and resiniferatoxin (RTX) can inhibit LPS- and IFN-gamma-mediated NO production, and iNOS protein and mRNA expression with similar IC50 values of around 10 microm. Capsaicin 0-9 interferon gamma Homo sapiens 57-66 14530214-5 2003 Capsaicin and resiniferatoxin (RTX) can inhibit LPS- and IFN-gamma-mediated NO production, and iNOS protein and mRNA expression with similar IC50 values of around 10 microm. resiniferatoxin 14-29 interferon gamma Homo sapiens 57-66 14530214-5 2003 Capsaicin and resiniferatoxin (RTX) can inhibit LPS- and IFN-gamma-mediated NO production, and iNOS protein and mRNA expression with similar IC50 values of around 10 microm. resiniferatoxin 31-34 interferon gamma Homo sapiens 57-66 14530214-19 2003 In conclusion, vanilloids can modulate the expression of inflammatory iNOS and COX-2 genes in macrophages through interference with upstream signalling events of LPS and IFN-gamma. vanilloids 15-25 interferon gamma Homo sapiens 170-179 14746803-3 2003 Using DD-PCR analysis, adenine nucleotide translocase (ANT) 3, an enzyme which exchanges ATP and ADP through mitochondrial membrane, has been identified as a novel target counter-regulated by IL-4 and IFN-gamma. Adenosine Triphosphate 89-92 interferon gamma Homo sapiens 201-210 14616870-11 2003 IFN-gamma and IL-10 were induced by BPA in both the bp-allergic and non-bp-allergic groups. bisphenol A 36-39 interferon gamma Homo sapiens 0-9 14616870-11 2003 IFN-gamma and IL-10 were induced by BPA in both the bp-allergic and non-bp-allergic groups. Benzo(a)pyrene 52-54 interferon gamma Homo sapiens 0-9 14616870-11 2003 IFN-gamma and IL-10 were induced by BPA in both the bp-allergic and non-bp-allergic groups. Benzo(a)pyrene 72-74 interferon gamma Homo sapiens 0-9 14746803-3 2003 Using DD-PCR analysis, adenine nucleotide translocase (ANT) 3, an enzyme which exchanges ATP and ADP through mitochondrial membrane, has been identified as a novel target counter-regulated by IL-4 and IFN-gamma. Adenosine Diphosphate 97-100 interferon gamma Homo sapiens 201-210 14746803-7 2003 Furthermore, regulation of ANT3 expression by IL-4 and IFN-gamma correlated with the modulation T cell survival by these cytokines from dex-induced apoptosis. Dextromethorphan 136-139 interferon gamma Homo sapiens 55-64 14572607-2 2003 Treatment with lovastatin resulted in the induction of LPS/IFN-gamma-mediated iNOS mRNA and increased nitric oxide (NO) production. Lovastatin 15-25 interferon gamma Homo sapiens 59-68 14579273-6 2003 Cyclosporin A, but not concanamycin A, an H+-ATPase vacuolar inhibitor which affects perforin and granzyme release, strongly reduced the sHLA-I-mediated CD8-dependent IFN-gamma production but did not affect cytolytic activity of NK cells, suggesting that different biochemical pathways are involved. Cyclosporine 0-13 interferon gamma Homo sapiens 167-176 14579273-7 2003 Altogether, these findings indicate that CD8 engagement by sHLA-I activates a cyclosporin A-dependent pathway leading to production and secretion of IFN-gamma which may play a role in the regulation of innate immune responses in humans. Cyclosporine 78-91 interferon gamma Homo sapiens 149-158 14572607-2 2003 Treatment with lovastatin resulted in the induction of LPS/IFN-gamma-mediated iNOS mRNA and increased nitric oxide (NO) production. Nitric Oxide 102-114 interferon gamma Homo sapiens 59-68 14600569-9 2003 Most Tet+ cells expressed a memory phenotype, showed an impaired ability to produce IFN-gamma when stimulated with the cognate peptide, and showed a very low expansion when cultured in the presence of the peptide. tetramethylenedisulfotetramine 5-8 interferon gamma Homo sapiens 84-93 14600569-10 2003 There was a negative correlation between the proportion of Tet+ cells producing IFN-gamma and plasma HIV-RNA. tetramethylenedisulfotetramine 59-62 interferon gamma Homo sapiens 80-89 14600569-12 2003 CONCLUSIONS: Most Tet+ cells in chronic HIV-infected individuals express a memory phenotype and show an impaired production of IFN-gamma and a lower proliferative response to specific HIV antigens. tetramethylenedisulfotetramine 18-21 interferon gamma Homo sapiens 127-136 14568937-5 2003 Moreover, we show that H2-D blockage inhibits the ability of immature B cells to transcribe the IFN-gamma gene and results in rescue of cytoskeletal rearrangement. Hydrogen 23-25 interferon gamma Homo sapiens 96-105 14598250-11 2003 Culture of IFN-gamma/TNF-treated CLPF for a further 7 days without cytokines did not restore the migratory potential and FAK phosphorylation, indicating a persistent functional change. clpf 33-37 interferon gamma Homo sapiens 11-20 14708625-0 2003 Induction of interferon regulatory factor 1 expression in human dermal endothelial cells by interferon-gamma and tumor necrosis factor-alpha is transcriptionally regulated and requires iron. Iron 185-189 interferon gamma Homo sapiens 92-140 14708625-2 2003 In this study, we determined that the generation of interferon regulatory factor-1 expression in human dermal microvascular endothelial cells was transcriptionally mediated by tumor necrosis factor-alpha or interferon-gamma via iron-dependent pathways. Iron 228-232 interferon gamma Homo sapiens 207-223 14708625-6 2003 Both tumor necrosis factor-alpha and interferon-gamma-induced interferon regulatory factor-1 gene transcription, as assessed by the measurement of unspliced, nascent, heterogeneous nuclear RNA, and treatment with iron chelators blocked tumor necrosis factor-alpha or interferon-gamma mediated interferon regulatory factor-1 gene transcription. Iron 213-217 interferon gamma Homo sapiens 37-53 14708625-6 2003 Both tumor necrosis factor-alpha and interferon-gamma-induced interferon regulatory factor-1 gene transcription, as assessed by the measurement of unspliced, nascent, heterogeneous nuclear RNA, and treatment with iron chelators blocked tumor necrosis factor-alpha or interferon-gamma mediated interferon regulatory factor-1 gene transcription. Iron 213-217 interferon gamma Homo sapiens 267-283 14597095-10 2003 Treatment with treosulfan resulted in reduced mRNA expression of IL-12 and interferon (IFN)-gamma in draining lymph nodes and reduced numbers of IFN-gamma-secreting MOG-specific T cells. treosulfan 15-25 interferon gamma Homo sapiens 75-97 14597095-10 2003 Treatment with treosulfan resulted in reduced mRNA expression of IL-12 and interferon (IFN)-gamma in draining lymph nodes and reduced numbers of IFN-gamma-secreting MOG-specific T cells. treosulfan 15-25 interferon gamma Homo sapiens 145-154 12975482-1 2003 In the course of other experiments, we serendipitously observed that extracellular nicotinamide adenine dinucleotide (NAD+) ameliorated the development of epithelial hyperpermeability when monolayers of Caco-2 enterocyte-like cells were incubated with cytomix, a mixture containing interferon-gamma, interleukin-1beta, and tumor necrosis factor-alpha. NAD 83-116 interferon gamma Homo sapiens 282-298 12975482-1 2003 In the course of other experiments, we serendipitously observed that extracellular nicotinamide adenine dinucleotide (NAD+) ameliorated the development of epithelial hyperpermeability when monolayers of Caco-2 enterocyte-like cells were incubated with cytomix, a mixture containing interferon-gamma, interleukin-1beta, and tumor necrosis factor-alpha. NAD 118-122 interferon gamma Homo sapiens 282-298 12933798-7 2003 Zoledronate inhibited sustained phosphorylation of focal adhesion kinase (FAK) and in combination with TNF, with and without interferon (IFN) gamma, of protein kinase B (PKB/Akt). Zoledronic Acid 0-11 interferon gamma Homo sapiens 125-147 14586410-11 2003 In addition, the inhibitory effect of IFN-gamma on TGF-beta-dependent GCTM-1 invasion vanished by the AS oligonucleotide of Smad7 transfection. Oligonucleotides 105-120 interferon gamma Homo sapiens 38-47 12855573-6 2003 Evidence indicates that Bryostatin 1 induces STAT1 activation through an interferon gamma (IFN gamma) autocrine loop. bryostatin 1 24-36 interferon gamma Homo sapiens 73-89 12855573-6 2003 Evidence indicates that Bryostatin 1 induces STAT1 activation through an interferon gamma (IFN gamma) autocrine loop. bryostatin 1 24-36 interferon gamma Homo sapiens 91-100 14530318-6 2003 Resting HMVEC and IFN-gamma-treated cells showed minimal cAMP response to the selective A(2A) receptor agonist 2-[2-(4-chlorophenyl)ethoxy]adenosine (MRE0094). Cyclic AMP 57-61 interferon gamma Homo sapiens 18-27 14530318-6 2003 Resting HMVEC and IFN-gamma-treated cells showed minimal cAMP response to the selective A(2A) receptor agonist 2-[2-(4-chlorophenyl)ethoxy]adenosine (MRE0094). 2-(2-(4-chlorophenyl)ethoxy)adenosine 111-148 interferon gamma Homo sapiens 18-27 14530318-6 2003 Resting HMVEC and IFN-gamma-treated cells showed minimal cAMP response to the selective A(2A) receptor agonist 2-[2-(4-chlorophenyl)ethoxy]adenosine (MRE0094). 2-(2-(4-chlorophenyl)ethoxy)adenosine 150-157 interferon gamma Homo sapiens 18-27 14530318-8 2003 The nonselective adenosine receptor agonist 5"-(N-ethylcarboxamido)adenosine increased cAMP levels in both TNF-alpha- and IFN-gamma-treated cells, but not control cells, and its effect was only partially reversed by ZM-241385 in TNF-alpha-treated cells and not affected in IFN-gamma-treated cells. Adenosine-5'-(N-ethylcarboxamide) 44-76 interferon gamma Homo sapiens 122-131 14530318-8 2003 The nonselective adenosine receptor agonist 5"-(N-ethylcarboxamido)adenosine increased cAMP levels in both TNF-alpha- and IFN-gamma-treated cells, but not control cells, and its effect was only partially reversed by ZM-241385 in TNF-alpha-treated cells and not affected in IFN-gamma-treated cells. Adenosine-5'-(N-ethylcarboxamide) 44-76 interferon gamma Homo sapiens 273-282 14530318-8 2003 The nonselective adenosine receptor agonist 5"-(N-ethylcarboxamido)adenosine increased cAMP levels in both TNF-alpha- and IFN-gamma-treated cells, but not control cells, and its effect was only partially reversed by ZM-241385 in TNF-alpha-treated cells and not affected in IFN-gamma-treated cells. Cyclic AMP 87-91 interferon gamma Homo sapiens 122-131 14530318-8 2003 The nonselective adenosine receptor agonist 5"-(N-ethylcarboxamido)adenosine increased cAMP levels in both TNF-alpha- and IFN-gamma-treated cells, but not control cells, and its effect was only partially reversed by ZM-241385 in TNF-alpha-treated cells and not affected in IFN-gamma-treated cells. ZM 241385 216-225 interferon gamma Homo sapiens 122-131 14577920-8 2003 In particular, the production level of interferon (IFN)-gamma from E7-specific CD4(+) T cells was similar between AdIL-12 group and AdIL-12 + E7 group. adil-12 114-121 interferon gamma Homo sapiens 39-61 14577920-8 2003 In particular, the production level of interferon (IFN)-gamma from E7-specific CD4(+) T cells was similar between AdIL-12 group and AdIL-12 + E7 group. adil-12 132-139 interferon gamma Homo sapiens 39-61 14577920-9 2003 However, IFN-gamma production from E7-specific CD8(+) T cells was the most significant when injected with AdIL-12 + E7. adil-12 106-113 interferon gamma Homo sapiens 9-18 14577920-10 2003 This was consistent with intracellular IFN-gamma staining levels of CD8(+) T cells, suggesting that AdIL-12 + E7 injection enhances antitumor immunity in the human papillomavirus (HPV) 16 tumor model through increased expansion of the cytotoxic T-lymphocyte (CTL) subset. adil-12 100-107 interferon gamma Homo sapiens 39-48 14580308-9 2003 Restoration of PPARalpha, T-bet, interleukin-2, and IFNgamma responses was found in T cells from aged animals supplemented with vitamin E, suggesting that interventions that focus on restoring redox balance might benefit the ailing aged immune system. Vitamin E 128-137 interferon gamma Homo sapiens 52-60 12918059-4 2003 IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO). tyrosyl-valyl-alanyl-aspartal 145-169 interferon gamma Homo sapiens 0-9 12918059-4 2003 IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO). tyrosyl-valyl-alanyl-aspartal 191-199 interferon gamma Homo sapiens 0-9 14555277-9 2003 Although CsA did not affect RANKL-induced osteoclast generation in the culture of monocytes alone, it completely rescued the T-cell-induced inhibition of osteoclast formation and strongly inhibited the production of GM-CSF and IFN-gamma. Cyclosporine 9-12 interferon gamma Homo sapiens 227-236 12974768-0 2003 Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis. Spironolactone 0-14 interferon gamma Homo sapiens 108-124 14653048-6 2003 RESULTS: Montelukast treatment induced a significant decrease of IL4 and IL13 levels (p < 0.001, for both comparisons), and a significant increase of IFN gamma (p < 0.001). montelukast 9-20 interferon gamma Homo sapiens 153-162 14653048-7 2003 CONCLUSIONS: Montelukast treatment reversed a typical Th2 cytokine pattern (IL4 and IL13) toward a Th1 (IFN gamma) predominance in children with PAR and EIA. montelukast 13-24 interferon gamma Homo sapiens 104-113 12950238-3 2003 In this study, the intracellular interleukin-4 and interferon-gamma production in CD4+ T-lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin was assessed via flow cytometry in order to determine the clinical significance of the Th1/Th2 ratio in 42 patients with ITP. Tetradecanoylphorbol Acetate 114-145 interferon gamma Homo sapiens 51-67 12950238-3 2003 In this study, the intracellular interleukin-4 and interferon-gamma production in CD4+ T-lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin was assessed via flow cytometry in order to determine the clinical significance of the Th1/Th2 ratio in 42 patients with ITP. Ionomycin 150-159 interferon gamma Homo sapiens 51-67 14499627-5 2003 The elevated PGE2 production by metastatic cancer cells was due to COX-2 activity since dual COX-1/2 inhibitor indomethacin and selective COX-2 inhibitor NS-398 equally suppressed both basal and inducible (by IFN-gamma/LPS or Ca2+-ionophores) PGE2 accumulation. Dinoprostone 13-17 interferon gamma Homo sapiens 209-218 12974768-4 2003 Spironolactone, at in vivo attainable doses, markedly suppressed transcription of several proinflammatory cytokines and, accordingly, inhibited release of tumour necrosis factor, lymphotoxin, interferon-gamma, granulocyte-macrophage colony-stimulating factor and interleukin 6 (70-90% inhibition). Spironolactone 0-14 interferon gamma Homo sapiens 192-276 14598940-9 2003 A431 epidermoid carcinoma cells pretreated with IC20 growth inhibitory concentrations of taxanes enhanced interferon gamma activated monocyte mediated ADCC killing through MDXH447. Taxoids 89-96 interferon gamma Homo sapiens 106-122 14499627-5 2003 The elevated PGE2 production by metastatic cancer cells was due to COX-2 activity since dual COX-1/2 inhibitor indomethacin and selective COX-2 inhibitor NS-398 equally suppressed both basal and inducible (by IFN-gamma/LPS or Ca2+-ionophores) PGE2 accumulation. Indomethacin 111-123 interferon gamma Homo sapiens 209-218 14499627-5 2003 The elevated PGE2 production by metastatic cancer cells was due to COX-2 activity since dual COX-1/2 inhibitor indomethacin and selective COX-2 inhibitor NS-398 equally suppressed both basal and inducible (by IFN-gamma/LPS or Ca2+-ionophores) PGE2 accumulation. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 154-160 interferon gamma Homo sapiens 209-218 12970138-13 2003 The proteasome inhibitor N-acetyl-leucinyl-leucinyl-norleucinal (ALLN 100 microM) reduced IFN-gamma/CD40L mediated cytokine induction, suggesting participation of NFkappaB, which was directly demonstrated by EMSA. Nitrogen 25-26 interferon gamma Homo sapiens 90-99 12970138-13 2003 The proteasome inhibitor N-acetyl-leucinyl-leucinyl-norleucinal (ALLN 100 microM) reduced IFN-gamma/CD40L mediated cytokine induction, suggesting participation of NFkappaB, which was directly demonstrated by EMSA. Cysteine 27-33 interferon gamma Homo sapiens 90-99 12970138-13 2003 The proteasome inhibitor N-acetyl-leucinyl-leucinyl-norleucinal (ALLN 100 microM) reduced IFN-gamma/CD40L mediated cytokine induction, suggesting participation of NFkappaB, which was directly demonstrated by EMSA. leucinyl 34-42 interferon gamma Homo sapiens 90-99 14519785-8 2003 Similar antiapoptotic effects of Gln occurred when apoptosis was induced by a combination of tumor necrosis factor-alpha and interferon-gamma. Glutamine 33-36 interferon gamma Homo sapiens 125-141 14507305-3 2003 The present data show that GlcN, but not GlcNAc, inhibits CD4+ T-cell proliferation, the generation of alloreactive cytotoxic T lymphocytes (CTLs) and the secretion of interferon-gamma (IFN-gamma) and interleukin-5 (IL-5) in primary MLC. Glucosamine 27-31 interferon gamma Homo sapiens 168-184 14512563-4 2003 Mouse splenocyte cultures treated with HSV DNA or HSV-derived oligodeoxyribonucleotides (ODNs) showed strong proliferative responses and production of inflammatory cytokines (gamma interferon [IFN-gamma], tumor necrosis factor [TNF], and interleukin-6 [IL-6]) in vitro, whereas splenocytes treated with mammalian CV-1 DNA or non-CpG ODN did not. Oligodeoxyribonucleotides 62-87 interferon gamma Homo sapiens 193-202 14512563-6 2003 Furthermore, HSV-ODN synergized with IFN-gamma to induce nitric oxide (NO), IL-6, and TNF production from macrophages. Nitric Oxide 57-69 interferon gamma Homo sapiens 37-46 14625004-1 2003 7alpha-Hydroxy-dehydroepiandrosterone and its 7beta-hydroxyepimer, which act as local immunomodulatory agents, dehydroepiandrosterone, cortisol, and major androgens, together with four cytokines-interleukins 2, 4, 10, and IFN-gamma, reflecting the activity of TH1 or TH2 cells present in semen, were measured in seminal plasma from 35 male donors. 7-hydroxydehydroepiandrosterone 0-37 interferon gamma Homo sapiens 222-231 14507305-3 2003 The present data show that GlcN, but not GlcNAc, inhibits CD4+ T-cell proliferation, the generation of alloreactive cytotoxic T lymphocytes (CTLs) and the secretion of interferon-gamma (IFN-gamma) and interleukin-5 (IL-5) in primary MLC. Glucosamine 27-31 interferon gamma Homo sapiens 186-195 14625004-1 2003 7alpha-Hydroxy-dehydroepiandrosterone and its 7beta-hydroxyepimer, which act as local immunomodulatory agents, dehydroepiandrosterone, cortisol, and major androgens, together with four cytokines-interleukins 2, 4, 10, and IFN-gamma, reflecting the activity of TH1 or TH2 cells present in semen, were measured in seminal plasma from 35 male donors. Dehydroepiandrosterone 15-37 interferon gamma Homo sapiens 222-231 14572312-1 2003 BACKGROUND: Arginine metabolism in tumor cell lines can be influenced by various cytokines, including recombinant human interferon-gamma (rIFN-gamma), a cytokine that shows promising clinical activity in epithelial ovarian cancer (EOC). Arginine 12-20 interferon gamma Homo sapiens 120-136 14625004-4 2003 A highly significant (P<0.001) positive correlation was found between seminal 7beta-hydroxy-dehydroepiandrosterone and IFN-gamma, while a negative correlation was found between cortisol and IL-10. 7-hydroxydehydroepiandrosterone 81-117 interferon gamma Homo sapiens 122-131 14625004-5 2003 Highly significant positive correlations were also found between serum 7alpha-hydroxy-dehydroepiandrosterone and seminal IFN-gamma and between serum 7beta-hydroxy-dehydroepiandrosterone and seminal IL-2, while a negative correlation was found between serum dehydroepiandrosterone and seminal IL-10. 7-hydroxydehydroepiandrosterone 71-108 interferon gamma Homo sapiens 121-130 14625004-5 2003 Highly significant positive correlations were also found between serum 7alpha-hydroxy-dehydroepiandrosterone and seminal IFN-gamma and between serum 7beta-hydroxy-dehydroepiandrosterone and seminal IL-2, while a negative correlation was found between serum dehydroepiandrosterone and seminal IL-10. Dehydroepiandrosterone 86-108 interferon gamma Homo sapiens 121-130 12963490-7 2003 Exposure to IFN-gamma increased IDO activity from 7+/-1 nmol to 129+/-11 nmol kynurenine/hr/mg protein. Kynurenine 78-88 interferon gamma Homo sapiens 12-21 12883826-7 2003 Furthermore, EGCg inhibited SEB-induced TNF-alpha and IFN- gamma production and IL-2, IFN-gamma, IL-10 and IL-12 p40 mRNA expression in human PBMCs from normal donors in a dose-dependent manner. epigallocatechin gallate 13-17 interferon gamma Homo sapiens 54-64 12963490-0 2003 Inhibition of indoleamine 2,3-dioxygenase activity in IFN-gamma stimulated astroglioma cells decreases intracellular NAD levels. NAD 117-120 interferon gamma Homo sapiens 54-63 12845646-9 2003 Increased IFN-gamma release was also observed after stimulation of T lymphocytes with DC loaded with doxo- and epi-treated (p< 0.02 and p< 0.005, respectively) but not with cis-treated DC. Doxorubicin 101-105 interferon gamma Homo sapiens 10-19 12807916-5 2003 On gene expression analysis, LY294002 selectively blocked the induction of a subset of 14 LPS/interferon-gamma (IFN-gamma)-induced genes, previously characterized as signal transducer and activator of transcription-1 (STAT1)-dependent. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 interferon gamma Homo sapiens 90-121 12807916-6 2003 LY294002, but not wortmannin, inhibited LPS/IFN-gamma-dependent STAT1 phosphorylation at Ser-727 and STAT1 activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 interferon gamma Homo sapiens 44-53 12807916-6 2003 LY294002, but not wortmannin, inhibited LPS/IFN-gamma-dependent STAT1 phosphorylation at Ser-727 and STAT1 activity. Serine 89-92 interferon gamma Homo sapiens 44-53 12807916-9 2003 Thus, LPS and IFN-gamma activate the PI3K and mTOR pathways, which converge to regulate STAT1-dependent transcription of pro-apoptotic and pro-inflammatory genes in a rapamycin-insensitive manner. Sirolimus 167-176 interferon gamma Homo sapiens 14-23 12948850-0 2003 Interferon gamma enhances proteasome activity in recombinant Hep G2 cells that express cytochrome P4502E1: modulation by ethanol. Ethanol 121-128 interferon gamma Homo sapiens 0-16 12948850-4 2003 Treatment of VL-17A cells with agents that inhibit CYP2E1 or the inducible nitric oxide synthase (iNOS) or that prevent the formation of peroxynitrite also blocked proteasome activation by IFNgamma, indicating that the proteasome may be directly activated by products of CYP2E1 and iNOS catalysis. Peroxynitrous Acid 137-150 interferon gamma Homo sapiens 189-197 12948850-7 2003 Ethanol treatment of VL-17A cells also caused a similar blockage of these same IFNgamma-mediated effects, by inhibiting STAT1 phosphorylation. Ethanol 0-7 interferon gamma Homo sapiens 79-87 12948850-8 2003 This inhibition was largely due to ethanol metabolism, as 4-methylpyrazole, an ethanol metabolism inhibitor, restored IFNgamma-mediated STAT1 phosphorylation in ethanol-treated cells. Ethanol 35-42 interferon gamma Homo sapiens 118-126 12948850-8 2003 This inhibition was largely due to ethanol metabolism, as 4-methylpyrazole, an ethanol metabolism inhibitor, restored IFNgamma-mediated STAT1 phosphorylation in ethanol-treated cells. Fomepizole 58-74 interferon gamma Homo sapiens 118-126 12948850-8 2003 This inhibition was largely due to ethanol metabolism, as 4-methylpyrazole, an ethanol metabolism inhibitor, restored IFNgamma-mediated STAT1 phosphorylation in ethanol-treated cells. Ethanol 79-86 interferon gamma Homo sapiens 118-126 12948850-8 2003 This inhibition was largely due to ethanol metabolism, as 4-methylpyrazole, an ethanol metabolism inhibitor, restored IFNgamma-mediated STAT1 phosphorylation in ethanol-treated cells. Ethanol 79-86 interferon gamma Homo sapiens 118-126 12948850-9 2003 Our results lead us to propose that IFNgamma initiates signal transduction, which alters the activities of CYP2E1 and iNOS, thereby producing reactive oxygen species. Reactive Oxygen Species 142-165 interferon gamma Homo sapiens 36-44 12948850-11 2003 Ethanol metabolism by VL-17A cells suppresses IFNgamma-mediated induction of proteasome activity, in part, by preventing STAT1 phosphorylation. Ethanol 0-7 interferon gamma Homo sapiens 46-54 12883826-7 2003 Furthermore, EGCg inhibited SEB-induced TNF-alpha and IFN- gamma production and IL-2, IFN-gamma, IL-10 and IL-12 p40 mRNA expression in human PBMCs from normal donors in a dose-dependent manner. epigallocatechin gallate 13-17 interferon gamma Homo sapiens 86-95 12938212-3 2003 Although DO shows a unique expression pattern compared to other MHC class II genes, prolonged IFN-gamma treatment of HeLa cells induced DOB expression. 2,5-dimethoxy-4-bromoamphetamine 136-139 interferon gamma Homo sapiens 94-103 14627128-11 2003 Both secretion of IL-12 p70 and IFN-gamma and activation of NF-kappaB induced by OK-432 were suppressed when imMo-DCs were pretreated with cytochalasin B. Cytochalasin B 139-153 interferon gamma Homo sapiens 32-41 13679813-0 2003 Human gamma/delta T-cell proliferation and IFN-gamma production induced by hexamethylene diisocyanate. 1,6-hexamethylene diisocyanate 75-101 interferon gamma Homo sapiens 6-52 14693487-0 2003 Cimetidine treatment for viral warts enhances IL-2 and IFN-gamma expression but not IL-18 expression in lesional skin. Cimetidine 0-10 interferon gamma Homo sapiens 55-64 14518165-8 2003 Furthermore, interferon gamma encourages clot formation and disrupts production of nitric oxide by endothelial cells. Nitric Oxide 83-95 interferon gamma Homo sapiens 13-29 17301373-1 2003 Neopterin, a pyrazinopyrimidine compound, is produced by macrophages after induction by interferon gamma (IFN-g) and serves as a marker of cellular immune system activation followed by oxidative stress. Neopterin 0-9 interferon gamma Homo sapiens 88-111 17301373-1 2003 Neopterin, a pyrazinopyrimidine compound, is produced by macrophages after induction by interferon gamma (IFN-g) and serves as a marker of cellular immune system activation followed by oxidative stress. Pteridines 13-31 interferon gamma Homo sapiens 88-111 12876215-2 2003 The extent and distribution of sulphate substitution on HS plays a vital role in regulation of the binding of a range of proteins, including IFN-gamma, several interleukins and most chemokines. Sulfates 31-39 interferon gamma Homo sapiens 141-150 12876215-2 2003 The extent and distribution of sulphate substitution on HS plays a vital role in regulation of the binding of a range of proteins, including IFN-gamma, several interleukins and most chemokines. Heparitin Sulfate 56-58 interferon gamma Homo sapiens 141-150 14565859-8 2003 Finally, antisense oligonucleotides specific for IRF-1 attenuated IFN-gamma growth inhibition in MDA436 and MDA468, confirming the direct role of IRF-1 in IFN-gamma growth inhibition. Oligonucleotides 19-35 interferon gamma Homo sapiens 66-75 12952926-4 2003 In the presence of concentrations of CTLA-4Ig that inhibited the CD28-B7 interaction, beryllium-specific CD4+ T cells in lung were still able to proliferate and secrete IFN-gamma in response to beryllium in culture. Beryllium 86-95 interferon gamma Homo sapiens 169-178 12952926-4 2003 In the presence of concentrations of CTLA-4Ig that inhibited the CD28-B7 interaction, beryllium-specific CD4+ T cells in lung were still able to proliferate and secrete IFN-gamma in response to beryllium in culture. Beryllium 194-203 interferon gamma Homo sapiens 169-178 14565859-8 2003 Finally, antisense oligonucleotides specific for IRF-1 attenuated IFN-gamma growth inhibition in MDA436 and MDA468, confirming the direct role of IRF-1 in IFN-gamma growth inhibition. Oligonucleotides 19-35 interferon gamma Homo sapiens 155-164 12966593-1 2003 OBJECTIVE: Activation of the enzyme indoleamine-(2,3)-dioxygenase (IDO) by interferon (IFN)-g leads to enhanced tryptophan conversion to kynurenine. Tryptophan 112-122 interferon gamma Homo sapiens 75-93 12940992-10 2003 Furthermore, the fact that C. trachomatis has retained the capacity to respond to tryptophan limitation supports the view that the in vivo antichlamydial effect of IFN-gamma is via the induction of the tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase. Tryptophan 82-92 interferon gamma Homo sapiens 164-173 12940992-10 2003 Furthermore, the fact that C. trachomatis has retained the capacity to respond to tryptophan limitation supports the view that the in vivo antichlamydial effect of IFN-gamma is via the induction of the tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase. Tryptophan 202-212 interferon gamma Homo sapiens 164-173 14517348-0 2003 Inhibition of interferon gamma signaling by the short chain fatty acid butyrate. Fatty Acids, Volatile 48-70 interferon gamma Homo sapiens 14-30 14517348-0 2003 Inhibition of interferon gamma signaling by the short chain fatty acid butyrate. Butyrates 71-79 interferon gamma Homo sapiens 14-30 14517348-4 2003 Here we report that butyrate is a strong inhibitor of signaling by IFN-gamma. Butyrates 20-28 interferon gamma Homo sapiens 67-76 14517348-5 2003 We demonstrated that this short chain fatty acid inhibits IFN-gamma-induced tyrosine and serine phosphorylation of STAT1. Fatty Acids, Volatile 26-48 interferon gamma Homo sapiens 58-67 14517348-5 2003 We demonstrated that this short chain fatty acid inhibits IFN-gamma-induced tyrosine and serine phosphorylation of STAT1. Tyrosine 76-84 interferon gamma Homo sapiens 58-67 14517348-5 2003 We demonstrated that this short chain fatty acid inhibits IFN-gamma-induced tyrosine and serine phosphorylation of STAT1. Serine 89-95 interferon gamma Homo sapiens 58-67 14517348-6 2003 IFN-gamma-induced JAK2 activation was inhibited by butyrate, implicating JAK2 as a target of butyrate action. Butyrates 51-59 interferon gamma Homo sapiens 0-9 14517348-6 2003 IFN-gamma-induced JAK2 activation was inhibited by butyrate, implicating JAK2 as a target of butyrate action. Butyrates 93-101 interferon gamma Homo sapiens 0-9 14517348-8 2003 Transient transfection experiments using a reporter gene construct containing eight GAS sites (gamma-activated sites) revealed that butyrate inhibits IFN-gamma induced, STAT1-dependent, transcriptional activation. Butyrates 132-140 interferon gamma Homo sapiens 150-159 14517348-10 2003 Thus, our data suggest that butyrate negatively regulates mucosal inflammation through the inhibition of IFN-gamma/STAT1 signaling. Butyrates 28-36 interferon gamma Homo sapiens 105-114 12966593-1 2003 OBJECTIVE: Activation of the enzyme indoleamine-(2,3)-dioxygenase (IDO) by interferon (IFN)-g leads to enhanced tryptophan conversion to kynurenine. Kynurenine 137-147 interferon gamma Homo sapiens 75-93 12955467-7 2003 In addition to the association with chemokines, heparan sulfate binds cytokines such as IFN-gamma and IL-2. Heparitin Sulfate 48-63 interferon gamma Homo sapiens 88-97 12950637-4 2003 IDO enzyme activity was evaluated by measurement of kynurenine levels in the interferon-gamma-treated and -untreated cells. Kynurenine 52-62 interferon gamma Homo sapiens 77-93 12813035-8 2003 Nuclear extracts from SW480 cells treated with IFN gamma show specific binding of oligonucleotides corresponding to this IRF-1-binding motif, which was supershifted by anti-IRF-1 antibody in electrophoretic mobility shift assay. Oligonucleotides 82-98 interferon gamma Homo sapiens 47-56 12950637-7 2003 The level of kynurenine measured, as the bioactivity of IDO enzyme, was significantly higher in the interferon-gamma-treated fibroblasts and keratinocytes compared to those of controls (p < 0.001). Kynurenine 13-23 interferon gamma Homo sapiens 100-116 12902477-7 2003 Importantly, human hepatic Valpha24(+) T cells are potent producers of IFN-gamma and TNF-alpha, but not IL-2 or IL-4, when stimulated pharmacologically or with the NKT cell ligand, alpha-galactosylceramide. alpha-galactosylceramide 181-205 interferon gamma Homo sapiens 71-80 12928114-6 2003 However, the biodistribution differed significantly; the number of exposed galactose residues was the major determinant of the specific distribution to the liver and blood clearance rate of hIFN-gamma. Galactose 75-84 interferon gamma Homo sapiens 190-200 12941469-3 2003 Exposure of human neuroblastoma cells, BE(2)-C, first to tyrosine phosphatase inhibitors (either phenylarsine oxide or PTP inhibitor-2) prevented Jak1, STAT1 and STAT3 activation elicited subsequently by either CNTF or interferon-gamma. oxophenylarsine 97-115 interferon gamma Homo sapiens 219-235 12941469-4 2003 In contrast, exposure of these cells to phosphatase inhibitors after initial stimulation by CNTF or interferon-gamma prevented the normal time-dependent decrease of total cellular phosphotyrosine-STAT levels as expected, while excluding already formed phosphotyrosine-STAT from the nucleus. Phosphotyrosine 180-195 interferon gamma Homo sapiens 100-116 12941469-4 2003 In contrast, exposure of these cells to phosphatase inhibitors after initial stimulation by CNTF or interferon-gamma prevented the normal time-dependent decrease of total cellular phosphotyrosine-STAT levels as expected, while excluding already formed phosphotyrosine-STAT from the nucleus. phosphotyrosine-stat 180-200 interferon gamma Homo sapiens 100-116 12902477-9 2003 However, hepatic cells from cancer patients and healthy donors release similar amounts of IFN-gamma in response to alpha-galactosylceramide. alpha-galactosylceramide 115-139 interferon gamma Homo sapiens 90-99 12794752-10 2003 Five of 7 pancreatic cancer cell lines became sensitive to agonistic anti-Fas antibody (CH-11) to various extents, without Fas upregulation, when exposed to CH-11 for 48 hr after pretreatment with IFNgamma. 4-dimethylamino-3',4'-dimethoxychalcone 157-162 interferon gamma Homo sapiens 197-205 12914930-1 2003 Neopterin is synthesized by human monocyte-derived macrophages primarily upon stimulation with the cytokine interferon-gamma. Neopterin 0-9 interferon gamma Homo sapiens 108-124 12766158-3 2003 The physiological role of IDO is not fully understood but is of great interest, because IDO is widely distributed in human tissues, can be up-regulated via cytokines such as interferon-gamma, and can thereby modulate the levels of tryptophan, which is vital for cell growth. Tryptophan 231-241 interferon gamma Homo sapiens 174-190 12907250-5 2003 Notably, IL-18 BPa:Fc (200 ng/mL) further reinforced dexamethasone (5 nM)- or mycophenolic acid (2 microM)-mediated reduction of LPS/IL-12-induced IFNgamma production by an additional 50.5 or 49.9%, respectively. Dexamethasone 53-66 interferon gamma Homo sapiens 147-155 12875900-7 2003 Acetate and propionate increased IFN-gamma production, whereas butyrate inhibited it. Acetates 0-7 interferon gamma Homo sapiens 33-42 12875900-7 2003 Acetate and propionate increased IFN-gamma production, whereas butyrate inhibited it. Propionates 12-22 interferon gamma Homo sapiens 33-42 12875900-8 2003 Acetate and propionate in combination were able to prevent the inhibitory effect of butyrate on IFN-gamma production. Acetates 0-7 interferon gamma Homo sapiens 96-105 12875900-8 2003 Acetate and propionate in combination were able to prevent the inhibitory effect of butyrate on IFN-gamma production. Propionates 12-22 interferon gamma Homo sapiens 96-105 12875900-8 2003 Acetate and propionate in combination were able to prevent the inhibitory effect of butyrate on IFN-gamma production. Butyrates 84-92 interferon gamma Homo sapiens 96-105 12907250-5 2003 Notably, IL-18 BPa:Fc (200 ng/mL) further reinforced dexamethasone (5 nM)- or mycophenolic acid (2 microM)-mediated reduction of LPS/IL-12-induced IFNgamma production by an additional 50.5 or 49.9%, respectively. Mycophenolic Acid 78-95 interferon gamma Homo sapiens 147-155 12869029-0 2003 Combined cyclosporin-A /prednisone therapy of patients with active uveitis suppresses IFN-gamma production and the function of dendritic cells. Prednisone 24-34 interferon gamma Homo sapiens 86-95 12919287-9 2003 hCIITAlo, a predicted 303-aa protein with deleted GTP-binding and carboxy-terminal domain, displayed a more subtle suppression of IFN-gamma-induced MHC class II expression. Guanosine Triphosphate 50-53 interferon gamma Homo sapiens 130-139 12871129-0 2003 Interferon-gamma-induced conversion of tryptophan: immunologic and neuropsychiatric aspects. Tryptophan 39-49 interferon gamma Homo sapiens 0-16 12884281-7 2003 Moreover, LPA or PA but not sphingosine 1-phosphate, enhances IFN-gamma secretion by activated NK cells. lysophosphatidic acid 10-13 interferon gamma Homo sapiens 62-71 12884281-7 2003 Moreover, LPA or PA but not sphingosine 1-phosphate, enhances IFN-gamma secretion by activated NK cells. Phosphatidic Acids 11-13 interferon gamma Homo sapiens 62-71 12884285-2 2003 Herein we demonstrate that short ISS (5-7 bases), which exhibit no activity on their own, induce IFN-gamma and IFN-alpha secretion from human peripheral blood mononuclear cells when adsorbed to the surface of cationic poly(D,L-lactide-co-glycolide) microparticles (cPLGA). Polylactic Acid-Polyglycolic Acid Copolymer 218-247 interferon gamma Homo sapiens 97-106 12838506-7 2003 Conversely, T-cell lysis was significantly decreased when IFN gamma-activated Sc were treated with concanamycin A, which inhibited perforin release. concanamycin A 99-113 interferon gamma Homo sapiens 58-67 14504669-2 2003 Neopterin concentrations measured in urine or blood reflect activation of cellular immunity and endogenous release of interferon-gamma. Neopterin 0-9 interferon gamma Homo sapiens 118-134 12799413-3 2003 Adenoviral vectors were used to express a non-secreted form of human IFNgamma or a non-secreted mutant form in which a previously demonstrated nuclear localization sequence (NLS), 128KTGKRKR134, was replaced with alanines at K and R positions. Alanine 213-221 interferon gamma Homo sapiens 69-82 12874239-0 2003 Glycosylinositolphosphate soluble variant surface glycoprotein inhibits IFN-gamma-induced nitric oxide production via reduction in STAT1 phosphorylation in African trypanosomiasis. glycosylinositolphosphate 0-25 interferon gamma Homo sapiens 72-81 12874239-0 2003 Glycosylinositolphosphate soluble variant surface glycoprotein inhibits IFN-gamma-induced nitric oxide production via reduction in STAT1 phosphorylation in African trypanosomiasis. Nitric Oxide 90-102 interferon gamma Homo sapiens 72-81 12874239-2 2003 During trypanosome infections, the host is exposed to parasite-derived molecules that mediate macrophage activation, specifically GPI anchor substituents associated with the shed variant surface glycoprotein (VSG), plus the host-activating agent IFN-gamma, which is derived from activated T cells and is essential for resistance to trypanosomes. Glycosylphosphatidylinositols 130-133 interferon gamma Homo sapiens 246-255 12874239-4 2003 Treatment of macrophages with IFN-gamma followed by GIP-sVSG (the soluble form of VSG containing the glycosylinositolphosphate substituent that is released by parasites) stimulated the induction of gene expression, including transcription of TNF-alpha, IL-6, GM-CSF, and IL-12p40. glycosylinositolphosphate 101-126 interferon gamma Homo sapiens 30-39 12885946-0 2003 Pathways for the regulation of interferon-gamma-inducible genes by iron in human monocytic cells. Iron 67-71 interferon gamma Homo sapiens 31-47 12885946-1 2003 To elucidate iron-regulated interferon-gamma (IFN-gamma) effector functions, we investigated three IFN-gamma-inducible genes [intercellular adhesion molecule-1 (ICAM-1), human leukocyte antigen (HLA)-DR, guanosine 5"-triphosphate-cyclohydrolase I (GTP-CH)] in primary human monocytes and the cell line THP-1. Iron 13-17 interferon gamma Homo sapiens 28-44 12885946-1 2003 To elucidate iron-regulated interferon-gamma (IFN-gamma) effector functions, we investigated three IFN-gamma-inducible genes [intercellular adhesion molecule-1 (ICAM-1), human leukocyte antigen (HLA)-DR, guanosine 5"-triphosphate-cyclohydrolase I (GTP-CH)] in primary human monocytes and the cell line THP-1. Iron 13-17 interferon gamma Homo sapiens 46-55 12885946-1 2003 To elucidate iron-regulated interferon-gamma (IFN-gamma) effector functions, we investigated three IFN-gamma-inducible genes [intercellular adhesion molecule-1 (ICAM-1), human leukocyte antigen (HLA)-DR, guanosine 5"-triphosphate-cyclohydrolase I (GTP-CH)] in primary human monocytes and the cell line THP-1. Iron 13-17 interferon gamma Homo sapiens 99-108 12885946-5 2003 IFN-gamma-inducible mRNA expression of ICAM-1, HLA-DR, and GTP-CH was reduced by iron and increased by DFO by a transcriptional mechanism. Iron 81-85 interferon gamma Homo sapiens 0-9 12885946-5 2003 IFN-gamma-inducible mRNA expression of ICAM-1, HLA-DR, and GTP-CH was reduced by iron and increased by DFO by a transcriptional mechanism. Deferoxamine 103-106 interferon gamma Homo sapiens 0-9 12885946-7 2003 Thus, iron perturbations regulate IFN-gamma effector pathways by transcriptional and post-transcriptional mechanisms, indicating that iron rather interferes with IFN-gamma signal-transduction processes. Iron 6-10 interferon gamma Homo sapiens 34-43 12885946-7 2003 Thus, iron perturbations regulate IFN-gamma effector pathways by transcriptional and post-transcriptional mechanisms, indicating that iron rather interferes with IFN-gamma signal-transduction processes. Iron 134-138 interferon gamma Homo sapiens 34-43 12885946-7 2003 Thus, iron perturbations regulate IFN-gamma effector pathways by transcriptional and post-transcriptional mechanisms, indicating that iron rather interferes with IFN-gamma signal-transduction processes. Iron 134-138 interferon gamma Homo sapiens 162-171 13678429-1 2003 Interferon-gamma (IFN-gamma)-induced indoleamine 2,3-dioxygenase (IDO) activity inhibits the growth of susceptible intracellular pathogens by catalyzing the oxidative cleavage of the indole ring of L-tryptophan and depleting pools of the essential amino acid. Tryptophan 198-210 interferon gamma Homo sapiens 0-27 13678429-1 2003 Interferon-gamma (IFN-gamma)-induced indoleamine 2,3-dioxygenase (IDO) activity inhibits the growth of susceptible intracellular pathogens by catalyzing the oxidative cleavage of the indole ring of L-tryptophan and depleting pools of the essential amino acid. Amino Acids, Essential 238-258 interferon gamma Homo sapiens 0-27 13678430-3 2003 In this study, we found that addition of the NO donor S-nitrosoglutathione (GSNO) to monocyte-derived DCs matured by lipopolysaccharide (LPS) or soluble CD40 ligand led to a decreased capacity to activate naive allogeneic T cells but a more prominent Th1 polarization, with increased interferon-gamma (IFN-gamma) secretion and reduced interleukin-5 (IL-5) release. S-Nitrosoglutathione 54-74 interferon gamma Homo sapiens 284-300 13678430-3 2003 In this study, we found that addition of the NO donor S-nitrosoglutathione (GSNO) to monocyte-derived DCs matured by lipopolysaccharide (LPS) or soluble CD40 ligand led to a decreased capacity to activate naive allogeneic T cells but a more prominent Th1 polarization, with increased interferon-gamma (IFN-gamma) secretion and reduced interleukin-5 (IL-5) release. S-Nitrosoglutathione 54-74 interferon gamma Homo sapiens 302-311 13678430-3 2003 In this study, we found that addition of the NO donor S-nitrosoglutathione (GSNO) to monocyte-derived DCs matured by lipopolysaccharide (LPS) or soluble CD40 ligand led to a decreased capacity to activate naive allogeneic T cells but a more prominent Th1 polarization, with increased interferon-gamma (IFN-gamma) secretion and reduced interleukin-5 (IL-5) release. S-Nitrosoglutathione 76-80 interferon gamma Homo sapiens 284-300 13678430-3 2003 In this study, we found that addition of the NO donor S-nitrosoglutathione (GSNO) to monocyte-derived DCs matured by lipopolysaccharide (LPS) or soluble CD40 ligand led to a decreased capacity to activate naive allogeneic T cells but a more prominent Th1 polarization, with increased interferon-gamma (IFN-gamma) secretion and reduced interleukin-5 (IL-5) release. S-Nitrosoglutathione 76-80 interferon gamma Homo sapiens 302-311 12828661-8 2003 Stronger expressions of AR, IL-2, and IFN-gamma were found in the NIGO group. nigo 66-70 interferon gamma Homo sapiens 38-47 12920241-3 2003 Human monocytes primed with IFN-gamma overlaid directly onto HRPE cells elicited significant increases in terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positive HRPE cells (p < 0.0001) and decreases of proliferating cell nuclear antigen-positive (p < 0.0001) HRPE cells. deoxyuridine triphosphate 153-157 interferon gamma Homo sapiens 28-37 12736393-4 2003 We examine the ability of GBS to induce the production of IFN-gamma, IL-18, and IL-12 by cord blood mixed mononuclear cells and compared these results with the IFN-gamma, IL-18, and IL-12 response of mixed mononuclear cells from adult blood. gbs 26-29 interferon gamma Homo sapiens 58-67 12736393-5 2003 We demonstrate that cord blood mixed mononuclear cells produced significantly less IFN-gamma, IL-18, and IL-12 in response to GBS compared with mixed mononuclear cells from adults. gbs 126-129 interferon gamma Homo sapiens 83-92 12736393-7 2003 The maximal cord blood cell production of IFN-gamma, in response to GBS, is achieved by priming the cells with both IL-18 and IL-12. gbs 68-71 interferon gamma Homo sapiens 42-51 12847270-0 2003 Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway. 15-deoxy-delta 12 140-157 interferon gamma Homo sapiens 14-23 12962036-2 2003 Although a prototype natural killer T(NKT) cell ligand, alpha-galactosylceramide(alpha-GC), would render NKT cells produce both IFN-gamma and IL-4, this novel ligand, an analog of alpha-GC with a truncated sphingosine chain, can induce a predominant production of IL-4. alpha-galactosylceramide 56-80 interferon gamma Homo sapiens 128-137 12962036-2 2003 Although a prototype natural killer T(NKT) cell ligand, alpha-galactosylceramide(alpha-GC), would render NKT cells produce both IFN-gamma and IL-4, this novel ligand, an analog of alpha-GC with a truncated sphingosine chain, can induce a predominant production of IL-4. alpha-gc 81-89 interferon gamma Homo sapiens 128-137 14580149-6 2003 Desferrioxamine, an iron chelator that mimics hypoxia in vitro, also inhibited the fractalkine production induced by IFN-gamma. Deferoxamine 0-15 interferon gamma Homo sapiens 117-126 14580149-6 2003 Desferrioxamine, an iron chelator that mimics hypoxia in vitro, also inhibited the fractalkine production induced by IFN-gamma. Iron 20-24 interferon gamma Homo sapiens 117-126 12962573-5 2003 GA-specific TCLs produce dominantly IL-2, IL-4, IFN-gamma and IL-10, but low levels of IL-6. Glatiramer Acetate 0-2 interferon gamma Homo sapiens 48-57 12962573-5 2003 GA-specific TCLs produce dominantly IL-2, IL-4, IFN-gamma and IL-10, but low levels of IL-6. tcls 12-16 interferon gamma Homo sapiens 48-57 12847270-0 2003 Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway. 14-prostaglandin j2 158-177 interferon gamma Homo sapiens 14-23 12847270-3 2003 The results show that IFN-gamma-induced inducible NO synthase (iNOS) gene transcription, iNOS protein induction, and NO production are more sensitive to inhibition by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15dPGJ(2)) than by the other two PPARgamma agonists, GW1929 and ciglitazone. 15-deoxy-delta 167-181 interferon gamma Homo sapiens 22-31 12847270-3 2003 The results show that IFN-gamma-induced inducible NO synthase (iNOS) gene transcription, iNOS protein induction, and NO production are more sensitive to inhibition by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15dPGJ(2)) than by the other two PPARgamma agonists, GW1929 and ciglitazone. prostaglandin j 189-204 interferon gamma Homo sapiens 22-31 12847270-3 2003 The results show that IFN-gamma-induced inducible NO synthase (iNOS) gene transcription, iNOS protein induction, and NO production are more sensitive to inhibition by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15dPGJ(2)) than by the other two PPARgamma agonists, GW1929 and ciglitazone. GW 1929 262-268 interferon gamma Homo sapiens 22-31 12847270-3 2003 The results show that IFN-gamma-induced inducible NO synthase (iNOS) gene transcription, iNOS protein induction, and NO production are more sensitive to inhibition by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15dPGJ(2)) than by the other two PPARgamma agonists, GW1929 and ciglitazone. ciglitazone 273-284 interferon gamma Homo sapiens 22-31 12847270-5 2003 Immunoblotting, DNA binding, and reporter gene assays consistently revealed the inhibitory ability of 15dPGJ(2), but not GW1929 or ciglitazone, on IFN-gamma-elicited signaling cascades, including tyrosine phosphorylation of Janus tyrosine protein kinase 2 and STAT1, DNA binding, and IFN regulatory factor-1 trans-activation of STAT1. Tyrosine 196-204 interferon gamma Homo sapiens 147-156 12814480-5 2003 Multiple regression analyses indicated that the correlations between the early ELISPOT measurements of interferon-gamma and serum creatinine were independent of acute rejection, delayed graft function, or the presence of panel reactive antibodies before transplantation. Creatinine 130-140 interferon gamma Homo sapiens 103-119 12890212-7 2003 In addition, serum levels of interferon-gamma, interleukin (IL)-6, IL-5 and eosinophil cationic protein, which were increased on admission, decreased dramatically after steroid therapy. Steroids 169-176 interferon gamma Homo sapiens 29-45 12859458-8 2003 In nickel-sensitive probands, an average precursor cell frequency of 19x10(5), 1.7x10(5), and 0.7x10(5) could be defined for IFN-gamma, IL-2, and IL-4 producing PBMC, respectively. Nickel 3-9 interferon gamma Homo sapiens 125-134 12901851-6 2003 In the control, treatment with TNBS led to a statistically significant (p < 0.05) upregulation of IFN-gamma mRNA expression in the inflammatory sites measured at post-treatment day 7. Trinitrobenzenesulfonic Acid 31-35 interferon gamma Homo sapiens 101-110 12811837-0 2003 Triggering of Toll-like receptors modulates IFN-gamma signaling: involvement of serine 727 STAT1 phosphorylation and suppressors of cytokine signaling. Serine 80-86 interferon gamma Homo sapiens 44-53 12811837-5 2003 Short costimulation resulted in the amplification of IFN-gamma signaling and was attributable to the p38 mitogen-activated protein kinase (MAPK)-dependent phosphorylation of signal transducer and activator of transcription (STAT)1 on serine 727. Serine 234-240 interferon gamma Homo sapiens 53-62 12811837-10 2003 Taken together, the results indicate a tight interplay between TLR and IFN-gamma signaling pathways which involve induction of SOCS proteins and serine phosphorylation of STAT1. Serine 145-151 interferon gamma Homo sapiens 71-80 12814390-2 2003 Cytokine interferon-gamma, which is released during cell-mediated immune responses, induces indoleamine (2,3)-dioxygenase (IDO), an enzyme degrading tryptophan to kynurenine. indolamine 92-103 interferon gamma Homo sapiens 9-25 12814390-2 2003 Cytokine interferon-gamma, which is released during cell-mediated immune responses, induces indoleamine (2,3)-dioxygenase (IDO), an enzyme degrading tryptophan to kynurenine. Tryptophan 149-159 interferon gamma Homo sapiens 9-25 12814390-2 2003 Cytokine interferon-gamma, which is released during cell-mediated immune responses, induces indoleamine (2,3)-dioxygenase (IDO), an enzyme degrading tryptophan to kynurenine. Kynurenine 163-173 interferon gamma Homo sapiens 9-25 12810356-11 2003 The results demonstrated a significant inhibition of calcineurin activity and IL-2 and IFN-gamma production in patients receiving cyclosporine monotherapy compared to healthy controls. Cyclosporine 130-142 interferon gamma Homo sapiens 87-96 12818436-4 2003 Spontaneous and phytohemaglutynine stimulated "in vitro" secretion of IL-2, IL-4, IL-6, IL-10, IL-12, IFN-gamma and TGF-beta by decidual lymphocytes was studied by ELISA. phytohemaglutynine 16-34 interferon gamma Homo sapiens 102-111 12810359-2 2003 Dopamine inhibited anti-CD3 mAb-induced release of both Th1 and Th2 cytokines, IL2, IFN-gamma and IL4 from T cells by specific class of dopamine receptors. Dopamine 0-8 interferon gamma Homo sapiens 84-93 12817007-7 2003 Thus, PKCdelta is activated during engagement of the IFN-gamma receptor and plays an important role in IFN-gamma signaling by mediating serine phosphorylation of Stat1 and facilitating transcription of IFN-gamma-stimulated genes. Serine 136-142 interferon gamma Homo sapiens 53-62 12911719-9 2003 Soluble CD40Lt did not enhance MO/MA cytotoxic activity, and inhibited IFN-gamma or IL-2 induced cytoxicity. cd40lt 8-14 interferon gamma Homo sapiens 71-80 12898413-5 2003 Results showed that the water-soluble compounds, namely aucubin, chlorogenic acid, ferulic acid, p-coumaric acid and vanillic acid, enhanced the activity of human lymphocyte proliferation and secretion of IFN-gamma. Water 24-29 interferon gamma Homo sapiens 205-214 12898413-5 2003 Results showed that the water-soluble compounds, namely aucubin, chlorogenic acid, ferulic acid, p-coumaric acid and vanillic acid, enhanced the activity of human lymphocyte proliferation and secretion of IFN-gamma. Chlorogenic Acid 65-81 interferon gamma Homo sapiens 205-214 12898413-5 2003 Results showed that the water-soluble compounds, namely aucubin, chlorogenic acid, ferulic acid, p-coumaric acid and vanillic acid, enhanced the activity of human lymphocyte proliferation and secretion of IFN-gamma. ferulic acid 83-95 interferon gamma Homo sapiens 205-214 12817007-7 2003 Thus, PKCdelta is activated during engagement of the IFN-gamma receptor and plays an important role in IFN-gamma signaling by mediating serine phosphorylation of Stat1 and facilitating transcription of IFN-gamma-stimulated genes. Serine 136-142 interferon gamma Homo sapiens 103-112 12817007-7 2003 Thus, PKCdelta is activated during engagement of the IFN-gamma receptor and plays an important role in IFN-gamma signaling by mediating serine phosphorylation of Stat1 and facilitating transcription of IFN-gamma-stimulated genes. Serine 136-142 interferon gamma Homo sapiens 103-112 12898413-5 2003 Results showed that the water-soluble compounds, namely aucubin, chlorogenic acid, ferulic acid, p-coumaric acid and vanillic acid, enhanced the activity of human lymphocyte proliferation and secretion of IFN-gamma. p-coumaric acid 97-112 interferon gamma Homo sapiens 205-214 12829919-7 2003 Whereas IL-18 significantly induced the expression of ICAM-1, B7.1, and B7.2 on monocytes in MLR and the production of interferon-gamma and IL-12, PGE2 inhibited these IL-18-initiated enhancements. Dinoprostone 147-151 interferon gamma Homo sapiens 119-135 12898413-5 2003 Results showed that the water-soluble compounds, namely aucubin, chlorogenic acid, ferulic acid, p-coumaric acid and vanillic acid, enhanced the activity of human lymphocyte proliferation and secretion of IFN-gamma. Vanillic Acid 117-130 interferon gamma Homo sapiens 205-214 12637577-5 2003 Expression of SBR-p38alpha in primary T lymphocytes abrogated the ability of SB 203580 to inhibit the production of interferon-gamma induced by co-ligation of CD3 and CD28 but not the production of interferon-gamma or IL-10 induced by IL-12. SB 203580 77-86 interferon gamma Homo sapiens 116-132 12794166-3 2003 In this study, we examined the molecular basis by which IFN-gamma differentially sensitized human primary and metastatic colon carcinoma cells to Fas-mediated apoptosis. ammonium ferrous sulfate 146-149 interferon gamma Homo sapiens 56-65 12794166-8 2003 Functional studies demonstrated that both caspase-1 and ICSBP were involved in Fas-mediated apoptosis following IFN-gamma sensitization, but proceeded via two distinct pathways. ammonium ferrous sulfate 79-82 interferon gamma Homo sapiens 112-121 12767900-1 2003 We previously reported synergistic induction of apoptosis by IFN-gamma plus either cyclosporin A (CsA) or tacrolimus (FK506) in gastric carcinoma cells. Tacrolimus 118-123 interferon gamma Homo sapiens 61-70 12767900-5 2003 When gastric carcinoma cells were treated with cyclohexamide, a protein synthesis inhibitor, following IFN-gamma pretreatment, caspase-3 was activated, and apoptosis was markedly induced. 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione 47-60 interferon gamma Homo sapiens 103-112 12767900-7 2003 IFN-gamma increased intracellular calcium ion concentration ([Ca(2+)](i)) consisting of a spike and a sustained phase, and the latter was completely abrogated by CsA. Calcium 34-41 interferon gamma Homo sapiens 0-9 12767900-8 2003 Activation of NF-kappa B occurred in response to IFN-gamma, and which was markedly inhibited by either CsA or FK506. Tacrolimus 110-115 interferon gamma Homo sapiens 49-58 12782301-0 2003 Early changes in glucose and phospholipid metabolism following apoptosis induction by IFN-gamma/TNF-alpha in HT-29 cells. Glucose 17-24 interferon gamma Homo sapiens 86-95 12744882-5 2003 The ex vivo evaluation of the CD8(+) T cell response by IFN-gamma ELISPOT assay revealed that the injection of polypeptide with OM-174 adjuvant induced, compared to IFA, a similar and an eight-fold increased frequency of peptide-specific lymphocytes in the draining lymph-nodes and in the spleen, respectively. defoslimod 128-134 interferon gamma Homo sapiens 56-65 12782301-0 2003 Early changes in glucose and phospholipid metabolism following apoptosis induction by IFN-gamma/TNF-alpha in HT-29 cells. Phospholipids 29-41 interferon gamma Homo sapiens 86-95 12782301-3 2003 Significantly increased lactate and NTP (all nucleoside 5"-triphosphates) signals were detected 4 h after apoptosis-inducing IFN-gamma/TNF-alpha treatment, but not in cells which were TNF-alpha-treated without IFN-gamma preincubation. Lactic Acid 24-31 interferon gamma Homo sapiens 125-134 12782301-3 2003 Significantly increased lactate and NTP (all nucleoside 5"-triphosphates) signals were detected 4 h after apoptosis-inducing IFN-gamma/TNF-alpha treatment, but not in cells which were TNF-alpha-treated without IFN-gamma preincubation. Lactic Acid 24-31 interferon gamma Homo sapiens 210-219 12782301-3 2003 Significantly increased lactate and NTP (all nucleoside 5"-triphosphates) signals were detected 4 h after apoptosis-inducing IFN-gamma/TNF-alpha treatment, but not in cells which were TNF-alpha-treated without IFN-gamma preincubation. ntp 36-39 interferon gamma Homo sapiens 125-134 12782301-3 2003 Significantly increased lactate and NTP (all nucleoside 5"-triphosphates) signals were detected 4 h after apoptosis-inducing IFN-gamma/TNF-alpha treatment, but not in cells which were TNF-alpha-treated without IFN-gamma preincubation. ntp 36-39 interferon gamma Homo sapiens 210-219 12782301-3 2003 Significantly increased lactate and NTP (all nucleoside 5"-triphosphates) signals were detected 4 h after apoptosis-inducing IFN-gamma/TNF-alpha treatment, but not in cells which were TNF-alpha-treated without IFN-gamma preincubation. nucleoside 5"-triphosphates 45-72 interferon gamma Homo sapiens 125-134 12846989-4 2003 Glial cells can release deleterious compounds such as proinflammatory cytokines (TNF-alpha, Il-1beta, IFN-gamma), which may act by stimulating nitric oxide production in glial cells, or which may exert a more direct deleterious effect on dopaminergic neurons by activating receptors that contain intracytoplasmic death domains involved in apoptosis. Nitric Oxide 143-155 interferon gamma Homo sapiens 102-111 12804528-1 2003 Neopterin (Neo) and 7,8-dihydroneopterin (H(2)Neo) are produced by human monocyte-derived macrophages upon stimulation with IFN-gamma. Neopterin 0-9 interferon gamma Homo sapiens 124-133 12623793-5 2003 Treatment of HLMVEC with 5 ng/ml interleukin-1beta and 200 U/ml interferon-gamma for 16 h upregulated B(1) receptors as shown by an approximately fourfold increase in prolonged (>20 min) output of NO in response to des-Arg(10)-kallidin, which was blocked by the B(1) antagonist des-Arg(10)-Leu(9)-kallidin. des-arg 218-225 interferon gamma Homo sapiens 64-80 12623793-5 2003 Treatment of HLMVEC with 5 ng/ml interleukin-1beta and 200 U/ml interferon-gamma for 16 h upregulated B(1) receptors as shown by an approximately fourfold increase in prolonged (>20 min) output of NO in response to des-Arg(10)-kallidin, which was blocked by the B(1) antagonist des-Arg(10)-Leu(9)-kallidin. des-arg 281-288 interferon gamma Homo sapiens 64-80 12623793-5 2003 Treatment of HLMVEC with 5 ng/ml interleukin-1beta and 200 U/ml interferon-gamma for 16 h upregulated B(1) receptors as shown by an approximately fourfold increase in prolonged (>20 min) output of NO in response to des-Arg(10)-kallidin, which was blocked by the B(1) antagonist des-Arg(10)-Leu(9)-kallidin. Leucine 293-296 interferon gamma Homo sapiens 64-80 12813001-7 2003 3 The selective CB2 receptor ligands JWH-015 and indomethacin morpholinylamide (BML-190), when added to THP-1 cells before stimulation with lipopolysaccharide (LPS) and IFN-gamma, reduced the toxicity of their culture supernatants to SH-SY5Y cells. indomethacin morpholinylamide 49-78 interferon gamma Homo sapiens 169-178 12804528-1 2003 Neopterin (Neo) and 7,8-dihydroneopterin (H(2)Neo) are produced by human monocyte-derived macrophages upon stimulation with IFN-gamma. Neopterin 0-3 interferon gamma Homo sapiens 124-133 12804528-1 2003 Neopterin (Neo) and 7,8-dihydroneopterin (H(2)Neo) are produced by human monocyte-derived macrophages upon stimulation with IFN-gamma. 7,8-dihydroneopterin 20-40 interferon gamma Homo sapiens 124-133 12804528-1 2003 Neopterin (Neo) and 7,8-dihydroneopterin (H(2)Neo) are produced by human monocyte-derived macrophages upon stimulation with IFN-gamma. h(2)neo 42-49 interferon gamma Homo sapiens 124-133 12769672-8 2003 This technique was used to monitor the transcription patterns of mRNA encoding TNF-alpha, IL-1beta, and Interferon-gamma in human cell lines or primary PBMC treated with inducers such as PMA, ionomycin, and endotoxin. Tetradecanoylphorbol Acetate 187-190 interferon gamma Homo sapiens 104-120 12769672-8 2003 This technique was used to monitor the transcription patterns of mRNA encoding TNF-alpha, IL-1beta, and Interferon-gamma in human cell lines or primary PBMC treated with inducers such as PMA, ionomycin, and endotoxin. Ionomycin 192-201 interferon gamma Homo sapiens 104-120 12766968-9 2003 Using this assay, we identified several new Pgp substrates, including monensin and retinol, and confirmed that interleukin-2 and interferon-gamma can be transported by Pgp. Vitamin A 83-90 interferon gamma Homo sapiens 129-145 12780691-5 2003 IFN-gamma production was depressed significantly in all groups of TB patients compared with the HTR group. Terbium 66-68 interferon gamma Homo sapiens 0-9 12750353-3 2003 Replacements at positions P-1 and P5 pointing to the TCR in both THd afforded higher levels of IFN-gamma and IL-4 production. Thiamine 65-68 interferon gamma Homo sapiens 95-104 12750353-10 2003 Interestingly, IFN-gamma primed by the THd correlated significantly with that induced by the TCd (P < 0.01). Thiamine 39-42 interferon gamma Homo sapiens 15-24 12750353-10 2003 Interestingly, IFN-gamma primed by the THd correlated significantly with that induced by the TCd (P < 0.01). 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 93-96 interferon gamma Homo sapiens 15-24 12750356-6 2003 Treatment of keratinocytes with Candida albicans, mannan, Mycobacterium tuberculosis or LPS with IFN-gamma resulted in the activation and nuclear translocation of NF-kappaB. Mannans 50-56 interferon gamma Homo sapiens 97-106 12789234-7 2003 IFN-gamma alone inhibited spontaneous VEGF release by ASMC and concentration-dependently attenuated IL-4-augmented, IL-5-augmented, or IL-13-augmented production of VEGF (P <.01). asmc 54-58 interferon gamma Homo sapiens 0-9 12789244-11 2003 Lamotrigine-stimulated T cells were cytotoxic and secreted perforin, IFN-gamma, IL-5, and macrophage inflammatory protein 1alpha, macrophage inflammatory protein 1beta, RANTES, and I-309. Lamotrigine 0-11 interferon gamma Homo sapiens 69-78 12886986-0 2003 Prostaglandin E2-mediated regulation of immunoglobulin G2 via interferon gamma. Dinoprostone 0-16 interferon gamma Homo sapiens 62-78 12886986-4 2003 This unusual relationship prompted the hypothesis that, in certain circumstances, PGE2 enhances rather than inhibits IFN-gamma production. Dinoprostone 82-86 interferon gamma Homo sapiens 117-126 12886986-8 2003 Remarkably, addition of IFN-gamma also restored IND-suppressed IgG2 but not IgG1. Indomethacin 48-51 interferon gamma Homo sapiens 24-33 12953796-9 2003 Flow cytometry also demonstrated that IFN-gamma elevated the internalization of FITC-OVA. fitc-ova 80-88 interferon gamma Homo sapiens 38-47 12886986-10 2003 Furthermore, IND suppressed IFN-gamma production and PGE2 increased IFN-gamma levels. Indomethacin 13-16 interferon gamma Homo sapiens 28-37 12953796-11 2003 Although both 10 and 50 ng/mL IFN-gamma stimulated mucosal permeability to the same extent, more FITC-OVA was internalized by Caco-2 cells incubated with 50 than with 10 ng/mL IFN-gamma. fitc-ova 97-105 interferon gamma Homo sapiens 176-185 12886986-12 2003 CONCLUSIONS: These findings support the concept that in certain circumstances, PGE2 production can lead to increased IFN-gamma and that this IFN-gamma selectively promotes IgG2 responses. Dinoprostone 79-83 interferon gamma Homo sapiens 117-126 12886986-13 2003 These data suggest that the elevated PGE2 observed in LAgP patients may contribute to increased IFN-gamma production and help explain elevated IgG2 responses. Dinoprostone 37-41 interferon gamma Homo sapiens 96-105 14523355-1 2003 OBJECTIVES: The purpose of this study was to determine the effects of estradiol and progesterone on interferon-gamma (IFN-gamma), interleukin (IL)-12, IL-10 and tumor necrosis factor-alpha (TNF-alpha) productions in polyclonal activators (phytohemagglutinin+lipopolysaccharide)-stimulated whole blood cultures. Progesterone 84-96 interferon gamma Homo sapiens 100-116 14523355-4 2003 RESULTS: At preovulatory concentrations, estradiol enhanced significantly IFN-gamma, IL-12 and IL-10, but not TNF-alpha, production levels and reversed the suppressive effect of hydrocortisone in PHA+LPS stimulated whole blood. Estradiol 41-50 interferon gamma Homo sapiens 74-83 12788634-8 2003 Western blot analysis showed that, in cells treated with interferon gamma, E5 could prevent the breakdown of Ii and block the formation of peptide-loaded, SDS-stable mature MHC class II dimers, correlating with diminished surface MHC class II expression. Sodium Dodecyl Sulfate 155-158 interferon gamma Homo sapiens 57-73 12782181-3 2003 Exposure of A498 cells to a cytokine mixture consisting of interferon gamma, interleukin-1 beta and tumor necrosis factor-alpha (TNF-alpha) increased nitrite production, iNOS mRNA and protein expression. Nitrites 150-157 interferon gamma Homo sapiens 59-75 12522003-4 2003 Combined treatment of cells with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) reduced TfR mRNA levels, surface expression, and iron uptake, and these effects were reversed by interleukin-10 (IL-10), thus stimulating TfR-mediated iron acquisition. Iron 140-144 interferon gamma Homo sapiens 33-49 12609974-9 2003 Consistent with this finding, IFN-gamma stimulated CK2 activity and the level of phosphorylated cAMP response element-binding protein, which is known to induce ICER gene transcription, and this response was inhibited in the presence of apigenin. Cyclic AMP 96-100 interferon gamma Homo sapiens 30-39 12609974-10 2003 These studies, therefore, identify a previously uncharacterized pathway, involving the IFN-gamma-mediated stimulation of CK2 activity, activation of cAMP response element-binding protein, and increased production of ICER, which may then play an important role in the inhibition of macrophage gene transcription by this cytokine. Cyclic AMP 149-153 interferon gamma Homo sapiens 87-96 12522003-4 2003 Combined treatment of cells with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) reduced TfR mRNA levels, surface expression, and iron uptake, and these effects were reversed by interleukin-10 (IL-10), thus stimulating TfR-mediated iron acquisition. Iron 140-144 interferon gamma Homo sapiens 51-60 12522003-4 2003 Combined treatment of cells with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) reduced TfR mRNA levels, surface expression, and iron uptake, and these effects were reversed by interleukin-10 (IL-10), thus stimulating TfR-mediated iron acquisition. Iron 242-246 interferon gamma Homo sapiens 33-49 12522003-4 2003 Combined treatment of cells with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) reduced TfR mRNA levels, surface expression, and iron uptake, and these effects were reversed by interleukin-10 (IL-10), thus stimulating TfR-mediated iron acquisition. Iron 242-246 interferon gamma Homo sapiens 51-60 12522003-5 2003 IFN-gamma and LPS dose-dependently increased the cellular expression of divalent metal transporter-1, a transmembrane transporter of ferrous iron, and stimulated the uptake of nontransferrin bound iron (NTBI) into cells. Iron 141-145 interferon gamma Homo sapiens 0-9 12522003-5 2003 IFN-gamma and LPS dose-dependently increased the cellular expression of divalent metal transporter-1, a transmembrane transporter of ferrous iron, and stimulated the uptake of nontransferrin bound iron (NTBI) into cells. Iron 197-201 interferon gamma Homo sapiens 0-9 12522003-5 2003 IFN-gamma and LPS dose-dependently increased the cellular expression of divalent metal transporter-1, a transmembrane transporter of ferrous iron, and stimulated the uptake of nontransferrin bound iron (NTBI) into cells. ntbi 203-207 interferon gamma Homo sapiens 0-9 12522003-6 2003 At the same time, IFN-gamma and LPS down-regulated the expression of ferroportin mRNA, a putative iron exporter, and decreased iron release from monocytes. Iron 98-102 interferon gamma Homo sapiens 18-27 12522003-6 2003 At the same time, IFN-gamma and LPS down-regulated the expression of ferroportin mRNA, a putative iron exporter, and decreased iron release from monocytes. Iron 127-131 interferon gamma Homo sapiens 18-27 12522003-8 2003 Our results demonstrate that the proinflammatory stimuli IFN-gamma and LPS increase the uptake of NTBI via stimulation of divalent metal transporter-1 expression and cause retention of the metal within monocytes by down-regulating ferroportin synthesis. ntbi 98-102 interferon gamma Homo sapiens 57-66 12522003-8 2003 Our results demonstrate that the proinflammatory stimuli IFN-gamma and LPS increase the uptake of NTBI via stimulation of divalent metal transporter-1 expression and cause retention of the metal within monocytes by down-regulating ferroportin synthesis. Metals 131-136 interferon gamma Homo sapiens 57-66 12704788-0 2003 Interferon-gamma induces reactive oxygen species and endoplasmic reticulum stress at the hepatic apoptosis. Reactive Oxygen Species 25-48 interferon gamma Homo sapiens 0-16 12706706-0 2003 BCG (Bacille of Calmette-Guerin) revaccination leads to improved in vitro IFN-gamma response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children. bcg 0-3 interferon gamma Homo sapiens 74-83 12706706-0 2003 BCG (Bacille of Calmette-Guerin) revaccination leads to improved in vitro IFN-gamma response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children. bacille 5-12 interferon gamma Homo sapiens 74-83 12706706-0 2003 BCG (Bacille of Calmette-Guerin) revaccination leads to improved in vitro IFN-gamma response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children. calmette-guerin 16-31 interferon gamma Homo sapiens 74-83 12719524-5 2003 Drinking tea, which contains l-theanine, a precursor of the nonpeptide antigen ethylamine, primed peripheral blood gammadelta T cells to mediate a memory response on reexposure to ethylamine and to secrete IFN-gamma in response to bacteria. theanine 29-39 interferon gamma Homo sapiens 206-215 12719524-5 2003 Drinking tea, which contains l-theanine, a precursor of the nonpeptide antigen ethylamine, primed peripheral blood gammadelta T cells to mediate a memory response on reexposure to ethylamine and to secrete IFN-gamma in response to bacteria. ethylamine 79-89 interferon gamma Homo sapiens 206-215 12704788-3 2003 In this study, we found that IFN-gamma induced generation of reactive oxygen species (ROS) in primary hepatocytes and that pyrrolidinedithiocarbamate (PDTC), an anti-oxidant reagent, completely suppressed IFN-gamma-induced hepatic apoptosis. Reactive Oxygen Species 61-84 interferon gamma Homo sapiens 29-38 12704788-3 2003 In this study, we found that IFN-gamma induced generation of reactive oxygen species (ROS) in primary hepatocytes and that pyrrolidinedithiocarbamate (PDTC), an anti-oxidant reagent, completely suppressed IFN-gamma-induced hepatic apoptosis. Reactive Oxygen Species 86-89 interferon gamma Homo sapiens 29-38 12704788-3 2003 In this study, we found that IFN-gamma induced generation of reactive oxygen species (ROS) in primary hepatocytes and that pyrrolidinedithiocarbamate (PDTC), an anti-oxidant reagent, completely suppressed IFN-gamma-induced hepatic apoptosis. pyrrolidine dithiocarbamic acid 123-149 interferon gamma Homo sapiens 205-214 12704788-3 2003 In this study, we found that IFN-gamma induced generation of reactive oxygen species (ROS) in primary hepatocytes and that pyrrolidinedithiocarbamate (PDTC), an anti-oxidant reagent, completely suppressed IFN-gamma-induced hepatic apoptosis. pyrrolidine dithiocarbamic acid 151-155 interferon gamma Homo sapiens 205-214 12704788-5 2003 However, IFN-gamma also induced the generation of ROS in IRF-1-deficient hepatocytes, cells insensitive to IFN-gamma-induced apoptosis. Reactive Oxygen Species 50-53 interferon gamma Homo sapiens 9-18 12704788-7 2003 Both PDTC and indomethacin also blocked IFN-gamma-induced release of cytochrome c from mitochondria. pyrrolidine dithiocarbamic acid 5-9 interferon gamma Homo sapiens 40-49 12704788-7 2003 Both PDTC and indomethacin also blocked IFN-gamma-induced release of cytochrome c from mitochondria. Indomethacin 14-26 interferon gamma Homo sapiens 40-49 12704788-11 2003 Both the ROS and ER stress induced by IFN-gamma may be complementary mediators that induce apoptosis in primary hepatocytes. Reactive Oxygen Species 9-12 interferon gamma Homo sapiens 38-47 12729920-1 2003 In this report, we demonstrate that NADPH oxidase is activated by tumor necrosis factor-alpha (TNF-alpha) plus interferon-gamma (IFN-gamma) in human monocytic cells (THP-1 cells) differentiated with phorbol ester (PMA) and that physiological concentration of 17beta-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-alpha plus IFN-gamma. Estradiol 259-275 interferon gamma Homo sapiens 111-127 12729920-1 2003 In this report, we demonstrate that NADPH oxidase is activated by tumor necrosis factor-alpha (TNF-alpha) plus interferon-gamma (IFN-gamma) in human monocytic cells (THP-1 cells) differentiated with phorbol ester (PMA) and that physiological concentration of 17beta-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-alpha plus IFN-gamma. Phorbol Esters 199-212 interferon gamma Homo sapiens 111-127 12729920-1 2003 In this report, we demonstrate that NADPH oxidase is activated by tumor necrosis factor-alpha (TNF-alpha) plus interferon-gamma (IFN-gamma) in human monocytic cells (THP-1 cells) differentiated with phorbol ester (PMA) and that physiological concentration of 17beta-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-alpha plus IFN-gamma. Phorbol Esters 199-212 interferon gamma Homo sapiens 129-138 12729920-1 2003 In this report, we demonstrate that NADPH oxidase is activated by tumor necrosis factor-alpha (TNF-alpha) plus interferon-gamma (IFN-gamma) in human monocytic cells (THP-1 cells) differentiated with phorbol ester (PMA) and that physiological concentration of 17beta-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-alpha plus IFN-gamma. Estradiol 259-275 interferon gamma Homo sapiens 129-138 12505790-3 2003 Treatment with the p38 inhibitor SB-203580, the MEK1 and MEK2 inhibitor U-0126, or the translational inhibitor cycloheximide inhibited the induction of C/EBP beta and IL-6 by IFN-gamma, whereas the MEK1 inhibitor PD-98059 or the tyrosine kinase inhibitor genistein had no effect. SB 203580 33-42 interferon gamma Homo sapiens 175-184 12695292-8 2003 UA and CSA were associated with a significant increase in the frequency of CD4+ T cells that produced IFN-gamma, whereas these conditions caused no significant difference in the frequency of CD4+ T cells that produced IL-4. Cyclosporine 7-10 interferon gamma Homo sapiens 102-111 12517740-0 2003 Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. 15- deoxy-delta 12 53-71 interferon gamma Homo sapiens 14-23 12517740-0 2003 Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. 14-prostaglandin j2 72-91 interferon gamma Homo sapiens 14-23 12517740-3 2003 We show that PGJ(2) inhibits interferon (IFN)-gamma-stimulated phosphorylation and DNA-binding activity of STAT1. 9-deoxy-delta-9-prostaglandin D2 13-19 interferon gamma Homo sapiens 29-51 12517740-7 2003 Last, we show that the inhibitory actions of a short 6-h pulse with PGJ(2) on IL-1 plus IFN-gamma-stimulated iNOS expression and NO production by beta-cells are persistent for extended periods (< or =48 h). 9-deoxy-delta-9-prostaglandin D2 68-74 interferon gamma Homo sapiens 88-97 12505790-3 2003 Treatment with the p38 inhibitor SB-203580, the MEK1 and MEK2 inhibitor U-0126, or the translational inhibitor cycloheximide inhibited the induction of C/EBP beta and IL-6 by IFN-gamma, whereas the MEK1 inhibitor PD-98059 or the tyrosine kinase inhibitor genistein had no effect. U 0126 72-78 interferon gamma Homo sapiens 175-184 12517740-8 2003 These findings suggest that PGJ(2) inhibits multiple cytokine-signaling pathways (IL-1 and IFN-gamma), that the inhibitory actions are persistent for extended periods, and that increased HSP70 expression correlates with, but does not appear to mediate, the inhibitory actions of PGJ(2) on IL-1 and IFN-gamma signaling in beta-cells. 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE 28-31 interferon gamma Homo sapiens 91-100 12517740-8 2003 These findings suggest that PGJ(2) inhibits multiple cytokine-signaling pathways (IL-1 and IFN-gamma), that the inhibitory actions are persistent for extended periods, and that increased HSP70 expression correlates with, but does not appear to mediate, the inhibitory actions of PGJ(2) on IL-1 and IFN-gamma signaling in beta-cells. 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE 28-31 interferon gamma Homo sapiens 298-307 12505790-3 2003 Treatment with the p38 inhibitor SB-203580, the MEK1 and MEK2 inhibitor U-0126, or the translational inhibitor cycloheximide inhibited the induction of C/EBP beta and IL-6 by IFN-gamma, whereas the MEK1 inhibitor PD-98059 or the tyrosine kinase inhibitor genistein had no effect. Cycloheximide 111-124 interferon gamma Homo sapiens 175-184 12505790-3 2003 Treatment with the p38 inhibitor SB-203580, the MEK1 and MEK2 inhibitor U-0126, or the translational inhibitor cycloheximide inhibited the induction of C/EBP beta and IL-6 by IFN-gamma, whereas the MEK1 inhibitor PD-98059 or the tyrosine kinase inhibitor genistein had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 213-221 interferon gamma Homo sapiens 175-184 12505790-3 2003 Treatment with the p38 inhibitor SB-203580, the MEK1 and MEK2 inhibitor U-0126, or the translational inhibitor cycloheximide inhibited the induction of C/EBP beta and IL-6 by IFN-gamma, whereas the MEK1 inhibitor PD-98059 or the tyrosine kinase inhibitor genistein had no effect. Genistein 255-264 interferon gamma Homo sapiens 175-184 12748674-0 2003 Interferon-gamma for delayed pulmonary toxicity syndrome resistant to steroids. Steroids 70-78 interferon gamma Homo sapiens 0-16 12748674-6 2003 We report the symptomatic and physiological improvement of a patient with severe steroid-resistant delayed pulmonary toxicity syndrome, following treatment with interferon-gamma. Steroids 81-88 interferon gamma Homo sapiens 161-177 12752591-6 2003 RESULTS: PGE1, PGE2 and PGE3 significantly and dose-dependently decreased the concentrations of the Th1 cytokines IL-2 and IFN-gamma by up to 50% and 70%, respectively. Alprostadil 9-13 interferon gamma Homo sapiens 123-132 12717690-5 2003 RESULTS: As compared to PBMPhi, CBMPhi showed a significantly decreased upregulation of CD80 and/or CD86 after stimulation with IFN-gamma, cAMP, CD40L, and alphaCD3. pbmphi 24-30 interferon gamma Homo sapiens 128-137 12717690-5 2003 RESULTS: As compared to PBMPhi, CBMPhi showed a significantly decreased upregulation of CD80 and/or CD86 after stimulation with IFN-gamma, cAMP, CD40L, and alphaCD3. cbmphi 32-38 interferon gamma Homo sapiens 128-137 12752591-6 2003 RESULTS: PGE1, PGE2 and PGE3 significantly and dose-dependently decreased the concentrations of the Th1 cytokines IL-2 and IFN-gamma by up to 50% and 70%, respectively. Dinoprostone 15-19 interferon gamma Homo sapiens 123-132 12752591-6 2003 RESULTS: PGE1, PGE2 and PGE3 significantly and dose-dependently decreased the concentrations of the Th1 cytokines IL-2 and IFN-gamma by up to 50% and 70%, respectively. prostaglandin E3 24-28 interferon gamma Homo sapiens 123-132 12752591-10 2003 The ratio of the concentrations of IFN-gamma to IL-4 was significantly decreased at PGE concentrations of 10-7 and 10-6 M with all three PGEs having similar effects. Prostaglandins E 84-87 interferon gamma Homo sapiens 35-44 12759491-0 2003 15-deoxy-delta(12,14)-prostaglandin J2 inhibits IFN-gamma-induced galectin-9 expression in cultured human umbilical vein endothelial cells. 15-deoxy-delta(12,14)-prostaglandin J2 0-38 interferon gamma Homo sapiens 48-57 12731040-4 2003 Both PBMC and LPMC exhibit enhanced secretion and transactivation of the -2.7 kb IFN-gamma promoter region following CD2 signaling, but the IFN-gamma STAT-binding region (within the first intron) serves as an orientation-independent enhancer of promoter activity only in LPMC. lpmc 14-18 interferon gamma Homo sapiens 81-90 12731040-6 2003 In LPMC, but not PBMC, CD2 mediates binding of STAT1 and STAT4 to the IFN-gamma intronic element. lpmc 3-7 interferon gamma Homo sapiens 70-79 12759491-3 2003 METHODS: We have studied the effect of 15d-PGJ(2) on the IFN-gamma-induced galectin-9 expression in human umbilical vein endothelial cells (HUVEC) in culture. 15d-pgj 39-46 interferon gamma Homo sapiens 57-66 12759491-4 2003 RESULTS: 15d-PGJ(2) inhibited the IFN-gamma-induced galectin-9 expression in a PPAR-gamma-independent manner, and also inhibited the adhesion of EoL-1 cells to an HUVEC monolayer treated with IFN-gamma. 15d-pgj 9-16 interferon gamma Homo sapiens 34-43 12759491-4 2003 RESULTS: 15d-PGJ(2) inhibited the IFN-gamma-induced galectin-9 expression in a PPAR-gamma-independent manner, and also inhibited the adhesion of EoL-1 cells to an HUVEC monolayer treated with IFN-gamma. 15d-pgj 9-16 interferon gamma Homo sapiens 192-201 12759491-5 2003 15d-PGJ(2) partially inhibited IFN-gamma-induced phosphorylation of STAT-1 in HUVEC. 15d-pgj 0-7 interferon gamma Homo sapiens 31-40 12768284-6 2003 It is produced by guanosine triphosphate via interferon-gamma, following the activation of T cells. Guanosine Triphosphate 18-40 interferon gamma Homo sapiens 45-61 12707366-3 2003 Addition of dexamethasone to PBMC cultures resulted in a dramatic inhibition of IFN-gamma activation of STAT1. Dexamethasone 12-25 interferon gamma Homo sapiens 80-89 12742536-2 2003 Neopterin is a pteridine, which is produced by monocytes/macrophages upon stimulation with the type 1 T cell-derived cytokine interferon-gamma. Neopterin 0-9 interferon gamma Homo sapiens 126-142 12742536-2 2003 Neopterin is a pteridine, which is produced by monocytes/macrophages upon stimulation with the type 1 T cell-derived cytokine interferon-gamma. Pteridines 15-24 interferon gamma Homo sapiens 126-142 12697811-4 2003 The results show that an inhibitor of HDACs, trichostatin A, enhances IFN-gamma-induced MHC-II expression, while HDAC1/HDAC2 inhibits IFN-gamma- and CIITA-induced MHC-II gene expression. trichostatin A 45-59 interferon gamma Homo sapiens 70-79 12804068-1 2003 Osteopontin (OPN) is an arginine-glycine-aspartate (RGD)-containing cytokine that increases macrophage expression of the Th1 cytokines interferon-gamma (IFN-gamma) and interleukin-12 (IL-12), and downregulates macrophage expression of IL-10. arginine-glycine-aspartate 24-50 interferon gamma Homo sapiens 135-151 12804068-1 2003 Osteopontin (OPN) is an arginine-glycine-aspartate (RGD)-containing cytokine that increases macrophage expression of the Th1 cytokines interferon-gamma (IFN-gamma) and interleukin-12 (IL-12), and downregulates macrophage expression of IL-10. arginine-glycine-aspartate 24-50 interferon gamma Homo sapiens 153-162 12806280-1 2003 Activated monocytes-macrophages may be associated with antitumor activity, and activation of these cells by certain cytokines, primarily interferon gamma (IFN-gamma), can be indicated by alterations in the concentrations of neopterin, nitrate, or tryptophan. Neopterin 224-233 interferon gamma Homo sapiens 137-164 12806280-1 2003 Activated monocytes-macrophages may be associated with antitumor activity, and activation of these cells by certain cytokines, primarily interferon gamma (IFN-gamma), can be indicated by alterations in the concentrations of neopterin, nitrate, or tryptophan. Nitrates 235-242 interferon gamma Homo sapiens 137-164 12806280-1 2003 Activated monocytes-macrophages may be associated with antitumor activity, and activation of these cells by certain cytokines, primarily interferon gamma (IFN-gamma), can be indicated by alterations in the concentrations of neopterin, nitrate, or tryptophan. Tryptophan 247-257 interferon gamma Homo sapiens 137-164 12806280-10 2003 The intraperitoneal delivery of rhIL-12 appears to be associated with an immediate, sustained, and dose-dependent increase in peritoneal fluid neopterin, associated in most patients by an increase in IFN-gamma and in certain patients by an increase in nitrate and a decrease in tryptophan concentrations. Neopterin 143-152 interferon gamma Homo sapiens 200-209 14506314-4 2003 Imipramine and mianserin exhibited similar activities enhancing unstimulated IFN-gamma and IL-10 production. Imipramine 0-10 interferon gamma Homo sapiens 77-86 12736818-6 2003 ELISA results showed that IFN-gamma production following stimulation with the 30-kDa Ag was significantly lower in each group of TB patients than in the HTR controls. Terbium 129-131 interferon gamma Homo sapiens 26-35 14506314-4 2003 Imipramine and mianserin exhibited similar activities enhancing unstimulated IFN-gamma and IL-10 production. Mianserin 15-24 interferon gamma Homo sapiens 77-86 14506314-7 2003 Lithium differed significantly from imipramine and mianserin, as it enhanced IL-2, IFN-gamma, IL-10 and TGF-beta production and inhibited only IL-4. Lithium 0-7 interferon gamma Homo sapiens 83-92 12841302-6 2003 There are suggestions that bosentan (for the pulmonary hypertension of scleroderma), cyclophosphamide (for SSc alveolitis), stem cell transplant, interferon-gamma (for interstitial pulmonary fibrosis), and methotrexate (for the skin thickening of diffuse scleroderma) may improve organ function or functional activities, but whether they are truly disease-modifying remains to be proven. Methotrexate 206-218 interferon gamma Homo sapiens 146-162 12667488-2 2003 The ubiquitous protein tyrosine phosphatase (PTP) called "T-cell protein tyrosine phosphatase" has been reported to mediate Tyr-dephosphorylation of both interferon-gamma (IFN-gamma)-induced PY-STAT1 and interkleukin-6 (IL-6)-induced PY-STAT3 in some cell lines. Tyrosine 124-127 interferon gamma Homo sapiens 154-181 12584735-0 2003 Role of IRF-1 and caspase-7 in IFN-gamma enhancement of Fas-mediated apoptosis in ACHN renal cell carcinoma cells. ammonium ferrous sulfate 56-59 interferon gamma Homo sapiens 31-40 12584735-6 2003 Our previous study demonstrated an increase in the susceptibility of ACHN cells, established from RCC, to Fas-mediated apoptosis by IFN-gamma, and the inhibition of this effect by the caspase-3 and -7 inhibitor, DEVD-CHO. ammonium ferrous sulfate 106-109 interferon gamma Homo sapiens 132-141 12584735-6 2003 Our previous study demonstrated an increase in the susceptibility of ACHN cells, established from RCC, to Fas-mediated apoptosis by IFN-gamma, and the inhibition of this effect by the caspase-3 and -7 inhibitor, DEVD-CHO. aspartyl-glutamyl-valyl-aspartal 212-220 interferon gamma Homo sapiens 132-141 12584735-8 2003 These results suggest that IRF-1 plays a pivotal role in the IFN-gamma-mediated-enhancement of Fas/CD95-mediated apoptosis, through regulation of DEVD-CHO-sensitive caspases, most likely caspase-7. aspartyl-glutamyl-valyl-aspartal 146-154 interferon gamma Homo sapiens 61-70 12667488-7 2003 Consistent with this selectivity, shorter term VO(4) treatment (1-2h) markedly increased PY-STAT1 levels in all cellular compartments of IFN-gamma-treated cells by >10-fold. vo(4) 47-52 interferon gamma Homo sapiens 137-146 12569559-8 2003 Retinoic acid-treated hepatoma cells induced IFN gamma production from cocultured NK cells and rendered themselves more susceptible to NK cells. Tretinoin 0-13 interferon gamma Homo sapiens 45-54 12551917-4 2003 SH2-Bbeta is tyrosyl-phosphorylated in response to GH and interferon-gamma, stimulators of JAK2, as well as in response to PDGF and nerve growth factor. cyclo(tyrosyl-tyrosyl) 13-20 interferon gamma Homo sapiens 58-74 12633663-1 2003 IFN-gamma contributes to the rejection of transplantable tumors and the inhibition of methylcholanthrene (MCA)-induced carcinogenesis by different mechanisms. Methylcholanthrene 86-104 interferon gamma Homo sapiens 0-9 12765533-2 2003 PMA caused an increase in the basal and IFNgamma-induced WRS protein content in HeLa and HEK293 cultured cells. Tetradecanoylphorbol Acetate 0-3 interferon gamma Homo sapiens 40-48 12680857-8 2003 IFN-gamma, IL-5, IL-10 and IL-13 production by CBMC cultured in the presence of SEB, PPD, PHA, house dust mite (HDM) allergen, ovalbumin (OVA) and cat allergen was determined. cbmc 47-51 interferon gamma Homo sapiens 0-9 12633663-1 2003 IFN-gamma contributes to the rejection of transplantable tumors and the inhibition of methylcholanthrene (MCA)-induced carcinogenesis by different mechanisms. Methylcholanthrene 106-109 interferon gamma Homo sapiens 0-9 12646658-6 2003 AG490, a specific inhibitor for Janus kinase 2 of the IFN-gamma signaling pathway, dose-dependently attenuated IFN-gamma-induced HMGB1 release. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 0-5 interferon gamma Homo sapiens 54-63 12786722-0 2003 Use of in vitro release of interferon-gamma in the diagnosis of contact allergy to potassium dichromate - a controlled study. Potassium Dichromate 83-103 interferon gamma Homo sapiens 27-43 12786722-1 2003 The use of in vitro release of interferon-gamma (IFN-gamma) in the diagnosis of contact allergy to potassium dichromate was studied in 20 patients who had positive patch tests to chromate and in 30 control subjects (10 patients with contact dermatitis, allergic to other allergens, 10 patients with other dermatologic diseases and 10 healthy subjects). Potassium Dichromate 99-119 interferon gamma Homo sapiens 31-47 12786722-1 2003 The use of in vitro release of interferon-gamma (IFN-gamma) in the diagnosis of contact allergy to potassium dichromate was studied in 20 patients who had positive patch tests to chromate and in 30 control subjects (10 patients with contact dermatitis, allergic to other allergens, 10 patients with other dermatologic diseases and 10 healthy subjects). Potassium Dichromate 99-119 interferon gamma Homo sapiens 49-58 12656657-3 2003 After the analysis of the lymphocyte sub-populations, the intracellular content of interferon-gamma (IFN-gamma) in phorbolmyristate acetate (PMA)-stimulated CD4+ and CD8+ lymphocytes was assayed. Tetradecanoylphorbol Acetate 115-139 interferon gamma Homo sapiens 83-99 12656657-3 2003 After the analysis of the lymphocyte sub-populations, the intracellular content of interferon-gamma (IFN-gamma) in phorbolmyristate acetate (PMA)-stimulated CD4+ and CD8+ lymphocytes was assayed. Tetradecanoylphorbol Acetate 115-139 interferon gamma Homo sapiens 101-110 12656657-3 2003 After the analysis of the lymphocyte sub-populations, the intracellular content of interferon-gamma (IFN-gamma) in phorbolmyristate acetate (PMA)-stimulated CD4+ and CD8+ lymphocytes was assayed. Tetradecanoylphorbol Acetate 141-144 interferon gamma Homo sapiens 83-99 12656657-3 2003 After the analysis of the lymphocyte sub-populations, the intracellular content of interferon-gamma (IFN-gamma) in phorbolmyristate acetate (PMA)-stimulated CD4+ and CD8+ lymphocytes was assayed. Tetradecanoylphorbol Acetate 141-144 interferon gamma Homo sapiens 101-110 12755381-8 2003 Pyrethroids inhibited IFN-gamma and IL-4 in both groups at around 10(-5) M. Only fenvalerate and S-bioallethrin combined with 10-fold PBO in the atopic-enriched blood basophil incubates caused a weak but significant increase in histamine release. Pyrethrins 0-11 interferon gamma Homo sapiens 22-31 12646658-6 2003 AG490, a specific inhibitor for Janus kinase 2 of the IFN-gamma signaling pathway, dose-dependently attenuated IFN-gamma-induced HMGB1 release. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 0-5 interferon gamma Homo sapiens 111-120 12856330-5 2003 IL-1 and tumor necrosis factor (TNF) enhance the serine phosphorylation of Stat1 that occurs in response to interferon-gamma (IFN-gamma) and potentiate IFN-gamma-mediated, Stat1-driven gene expression, thus contributing to the synergistic activities of these proinflammatory cytokines. Serine 49-55 interferon gamma Homo sapiens 108-124 12856330-5 2003 IL-1 and tumor necrosis factor (TNF) enhance the serine phosphorylation of Stat1 that occurs in response to interferon-gamma (IFN-gamma) and potentiate IFN-gamma-mediated, Stat1-driven gene expression, thus contributing to the synergistic activities of these proinflammatory cytokines. Serine 49-55 interferon gamma Homo sapiens 126-135 12856330-5 2003 IL-1 and tumor necrosis factor (TNF) enhance the serine phosphorylation of Stat1 that occurs in response to interferon-gamma (IFN-gamma) and potentiate IFN-gamma-mediated, Stat1-driven gene expression, thus contributing to the synergistic activities of these proinflammatory cytokines. Serine 49-55 interferon gamma Homo sapiens 152-161 12714245-4 2003 The production of IL-2 and IFN-gamma by the different subpopulations was studied following stimulation with PMA and Ionomycin. Tetradecanoylphorbol Acetate 108-111 interferon gamma Homo sapiens 27-36 12640199-5 2003 Morphine decreased the in vitro levels of interferon-gamma (IFN gamma) and IL-2 during single infections, and this effect was reversed by the addition of the opioid antagonist naloxone. Morphine 0-8 interferon gamma Homo sapiens 42-58 12640199-5 2003 Morphine decreased the in vitro levels of interferon-gamma (IFN gamma) and IL-2 during single infections, and this effect was reversed by the addition of the opioid antagonist naloxone. Morphine 0-8 interferon gamma Homo sapiens 60-69 12640199-5 2003 Morphine decreased the in vitro levels of interferon-gamma (IFN gamma) and IL-2 during single infections, and this effect was reversed by the addition of the opioid antagonist naloxone. Naloxone 176-184 interferon gamma Homo sapiens 42-58 12640199-5 2003 Morphine decreased the in vitro levels of interferon-gamma (IFN gamma) and IL-2 during single infections, and this effect was reversed by the addition of the opioid antagonist naloxone. Naloxone 176-184 interferon gamma Homo sapiens 60-69 12640199-6 2003 In contrast, treatment with morphine resulted in a 31% and 36% increase in IFN gamma and IL-2 levels, respectively, during dual infection. Morphine 28-36 interferon gamma Homo sapiens 75-84 12640199-7 2003 In addition, naloxone had an apparent additive effect on the morphine-associated enhancement of IFN gamma and IL-2 expression in the dual-infection model. Naloxone 13-21 interferon gamma Homo sapiens 96-105 12640199-7 2003 In addition, naloxone had an apparent additive effect on the morphine-associated enhancement of IFN gamma and IL-2 expression in the dual-infection model. Morphine 61-69 interferon gamma Homo sapiens 96-105 12714245-4 2003 The production of IL-2 and IFN-gamma by the different subpopulations was studied following stimulation with PMA and Ionomycin. Ionomycin 116-125 interferon gamma Homo sapiens 27-36 12675756-2 2003 A number of conflicting reports led us to examine the effects of method of birth on CBMC production of interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and interleukin-12 (IL-12). cbmc 84-88 interferon gamma Homo sapiens 103-119 12675756-2 2003 A number of conflicting reports led us to examine the effects of method of birth on CBMC production of interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and interleukin-12 (IL-12). cbmc 84-88 interferon gamma Homo sapiens 121-130 12675756-4 2003 CBMC from vaginally delivered infants responded to stimulation with concanavalin A/phorbol 12-myristate 13-acetate (Con A/PMA), phytohemagglutinin (PHA), and lipopolysaccharide (LPS) with significantly higher levels of IFN-gamma than CBMC from unlabored cesarean section (CS) infants. cbmc 0-4 interferon gamma Homo sapiens 219-228 12787470-10 2003 Bryostatin 1 may be considered for further investigation of IFNg-dependent MHCII induction in resistant tumors in vivo. bryostatin 1 0-12 interferon gamma Homo sapiens 60-64 12720152-2 2003 Although its molecular mechanisms of action have not yet been elucidated, thalidomide and the IMiDs affect a variety of cytokines and inflammatory mediators including tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-1beta, interferon gamma (IFNgamma), IL-6, IL-10, IL-12, and COX-2 and angiogenesis factors such as vascular endothelial growth factor (VEGF) and its receptor. Thalidomide 74-85 interferon gamma Homo sapiens 231-247 12720152-2 2003 Although its molecular mechanisms of action have not yet been elucidated, thalidomide and the IMiDs affect a variety of cytokines and inflammatory mediators including tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-1beta, interferon gamma (IFNgamma), IL-6, IL-10, IL-12, and COX-2 and angiogenesis factors such as vascular endothelial growth factor (VEGF) and its receptor. Thalidomide 74-85 interferon gamma Homo sapiens 249-257 12787470-0 2003 Phorbol myristate acetate and Bryostatin 1 rescue IFN-gamma inducibility of MHC class II molecules in LS1034 colorectal carcinoma cell line. bryostatin 1 30-42 interferon gamma Homo sapiens 50-59 12614893-4 2003 In comparison, the down-regulation of inducible nitric oxide (iNOS) mRNA levels was less pronounced, but interferon gamma (IFN-gamma) mRNA was dose-dependently up-regulated with curcumin concentrations up to 8.2 microM. Curcumin 178-186 interferon gamma Homo sapiens 105-132 12626548-7 2003 Depletion of extracellular ATP also inhibited secretion of IFN-gamma, but not IL-4, supporting the interpretation that extracellular ATP is required for secretion of some, but not all, cytokines. Adenosine Triphosphate 27-30 interferon gamma Homo sapiens 59-68 12626548-0 2003 Secretion of IL-2 and IFN-gamma, but not IL-4, by antigen-specific T cells requires extracellular ATP. Adenosine Triphosphate 98-101 interferon gamma Homo sapiens 22-31 12626548-7 2003 Depletion of extracellular ATP also inhibited secretion of IFN-gamma, but not IL-4, supporting the interpretation that extracellular ATP is required for secretion of some, but not all, cytokines. Adenosine Triphosphate 133-136 interferon gamma Homo sapiens 59-68 12645529-7 2003 A STAT1 dominant negative mutant vector at Tyr-701 (JAK kinase phosphorylation site) blocked the effect of IFN-gamma on the p11 promoter activity. Tyrosine 43-46 interferon gamma Homo sapiens 107-116 12645529-8 2003 IFN-gamma induced a rapid tyrosine phosphorylation and nuclear translocation of STAT1 protein, which is involved in the binding to the GAS-2 site in the p11 promoter by EMSA analysis. Tyrosine 26-34 interferon gamma Homo sapiens 0-9 12645529-10 2003 Inhibition of p11 expression by inhibitory antisense RNAs (iRNA) treatment resulted in enhanced IFN-gamma and calcium ionophore-stimulated arachidonic acid release suggesting that at least in part IFN-gamma-stimulated p11 expression may serve a counterregulatory role. Calcium 110-117 interferon gamma Homo sapiens 197-206 12645529-10 2003 Inhibition of p11 expression by inhibitory antisense RNAs (iRNA) treatment resulted in enhanced IFN-gamma and calcium ionophore-stimulated arachidonic acid release suggesting that at least in part IFN-gamma-stimulated p11 expression may serve a counterregulatory role. Arachidonic Acid 139-155 interferon gamma Homo sapiens 197-206 12700631-8 2003 Conversely, cells expressing a dominant-negative mutant of Hsp27, in which three serine residues (15, 78 and 82) were replaced by glycine, were hypersensitive to the effects of IFN-gamma and exhibited a typical apoptotic phenotype. Glycine 130-137 interferon gamma Homo sapiens 177-186 12628494-6 2003 Significantly lower doses of IFN-gamma induced ROS accumulation in neutrophils and mononuclear cell of FA patients compared to cells of normal individuals. Reactive Oxygen Species 47-50 interferon gamma Homo sapiens 29-38 12628494-7 2003 Enhanced ROS accumulation and decreased intracellular glutathione levels were observed in FA-C B-cell lines primed with IFN-gamma and treated with agonistic anti-Fas antibody than in isogenic control cells corrected with FANCC. Reactive Oxygen Species 9-12 interferon gamma Homo sapiens 120-129 12628494-7 2003 Enhanced ROS accumulation and decreased intracellular glutathione levels were observed in FA-C B-cell lines primed with IFN-gamma and treated with agonistic anti-Fas antibody than in isogenic control cells corrected with FANCC. Glutathione 54-65 interferon gamma Homo sapiens 120-129 12628494-9 2003 That antioxidants reduced the priming effect of IFN-gamma in Fas and IFN-gamma-treated FA lymphoblast cells, demonstrates that ROS represent a critical effector mechanism for the exaggerated responses to IFN-gamma characteristic of FA-C cells. Reactive Oxygen Species 127-130 interferon gamma Homo sapiens 48-57 12628494-9 2003 That antioxidants reduced the priming effect of IFN-gamma in Fas and IFN-gamma-treated FA lymphoblast cells, demonstrates that ROS represent a critical effector mechanism for the exaggerated responses to IFN-gamma characteristic of FA-C cells. Reactive Oxygen Species 127-130 interferon gamma Homo sapiens 69-78 12628494-9 2003 That antioxidants reduced the priming effect of IFN-gamma in Fas and IFN-gamma-treated FA lymphoblast cells, demonstrates that ROS represent a critical effector mechanism for the exaggerated responses to IFN-gamma characteristic of FA-C cells. Reactive Oxygen Species 127-130 interferon gamma Homo sapiens 69-78 12700631-9 2003 Pretreatment of cells with IFN-gamma enhanced apoptotic cell death induced by cisplatin. Cisplatin 78-87 interferon gamma Homo sapiens 27-36 12579348-5 2003 The aim of this study was to assess the effect of IFN-gamma and TGF-beta on adherence and intracellular viability in ECV304 cells of GBS serotype III isolated from cerebrospinal fluid (CSF) and vagina (strains 90356 and 80340, respectively). gbs 133-136 interferon gamma Homo sapiens 50-59 12579348-10 2003 Treatment of ECV304 cells with IFN-gamma and/or TGF-beta increased adherence of both GBS strains (P<0.001). gbs 85-88 interferon gamma Homo sapiens 31-40 12579335-10 2003 IFN-gamma production was also detected in 4 out of 6 patients producing IL-2 by stimulation with CII. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 97-100 interferon gamma Homo sapiens 0-9 12579348-12 2003 Our data suggest that both IFN-gamma and TGF-beta may favor virulence of GBS strains. gbs 73-76 interferon gamma Homo sapiens 27-36 12639819-5 2003 Finally, DC incubated with OM-197 after pulsing with hepatitis B surface antigen (HBs Ag) induced in vitro expansion of IFN-gamma-secreting HBs Ag-specific CD4(+) T lymphocytes from naive individuals. om-197 27-33 interferon gamma Homo sapiens 120-129 12595457-9 2003 Immunoblotting showed that infection with EHEC, but not infection with EPEC, eliminated IFN-gamma-induced Stat1 tyrosine phosphorylation in both dose- and time-dependent fashions and disrupted inducible protein expression of the Stat1-dependent gene interferon regulatory factor 1. Tyrosine 112-120 interferon gamma Homo sapiens 88-97 12603854-4 2003 17beta-estradiol inhibited interferon-gamma-induced interferon-induced protein of 10 kDa secretion, mRNA expression, and promoter activity. Estradiol 0-16 interferon gamma Homo sapiens 27-43 12603854-6 2003 Interferon-gamma-induced protein of 10 kDa production was also inhibited by anti-estrogens, ICI 182 780 and tamoxifen, and membrane-impermeable bovine serum albumin-conjugated 17beta-estradiol, suggesting the effects via membrane estrogen receptor, whereas 17alpha-estradiol, progesterone, and dihydrotestosterone had no effects. Tamoxifen 108-117 interferon gamma Homo sapiens 0-16 12603854-6 2003 Interferon-gamma-induced protein of 10 kDa production was also inhibited by anti-estrogens, ICI 182 780 and tamoxifen, and membrane-impermeable bovine serum albumin-conjugated 17beta-estradiol, suggesting the effects via membrane estrogen receptor, whereas 17alpha-estradiol, progesterone, and dihydrotestosterone had no effects. Estradiol 176-192 interferon gamma Homo sapiens 0-16 12603854-6 2003 Interferon-gamma-induced protein of 10 kDa production was also inhibited by anti-estrogens, ICI 182 780 and tamoxifen, and membrane-impermeable bovine serum albumin-conjugated 17beta-estradiol, suggesting the effects via membrane estrogen receptor, whereas 17alpha-estradiol, progesterone, and dihydrotestosterone had no effects. alfatradiol 257-274 interferon gamma Homo sapiens 0-16 12603854-6 2003 Interferon-gamma-induced protein of 10 kDa production was also inhibited by anti-estrogens, ICI 182 780 and tamoxifen, and membrane-impermeable bovine serum albumin-conjugated 17beta-estradiol, suggesting the effects via membrane estrogen receptor, whereas 17alpha-estradiol, progesterone, and dihydrotestosterone had no effects. Progesterone 276-288 interferon gamma Homo sapiens 0-16 12612142-0 2003 Biotin supplementation increases expression of genes encoding interferon-gamma, interleukin-1beta, and 3-methylcrotonyl-CoA carboxylase, and decreases expression of the gene encoding interleukin-4 in human peripheral blood mononuclear cells. Biotin 0-6 interferon gamma Homo sapiens 62-78 12603854-6 2003 Interferon-gamma-induced protein of 10 kDa production was also inhibited by anti-estrogens, ICI 182 780 and tamoxifen, and membrane-impermeable bovine serum albumin-conjugated 17beta-estradiol, suggesting the effects via membrane estrogen receptor, whereas 17alpha-estradiol, progesterone, and dihydrotestosterone had no effects. Dihydrotestosterone 294-313 interferon gamma Homo sapiens 0-16 12612142-6 2003 The abundance of mRNA encoding interferon-gamma, interleukin-1beta, and 3-methylcrotonyl-CoA carboxylase was 4.3, 5.6 and 8.9 times greater, respectively, after supplementation with biotin compared with before supplementation. Biotin 182-188 interferon gamma Homo sapiens 31-47 12603854-7 2003 17beta-estradiol and bovine serum albumin-conjugated 17beta-estradiol suppressed interferon-gamma-induced transcription through the interferon-stimulated response element and signal transducer and activator of transcription 1alpha binding to interferon-stimulated response element. Estradiol 0-16 interferon gamma Homo sapiens 81-97 12620644-6 2003 When cells were co-treated with increasing doses of rhGGF2 and PMA or IFNgamma, only concentrations of 50 ng/ml, but not 10 or 100 ng/ml, were able to decrease oxidative burst activity and nitrite release. Nitrites 189-196 interferon gamma Homo sapiens 70-78 12620656-6 2003 Most MBP peptide-specific TCLs secreted considerable amounts of IFN-gamma and low amounts of IL-4 and IL-6, whereas anti rhMOG(Igd) peptide-specific TCLs secreted preferentially IL-4 and IL-6. tcls 26-30 interferon gamma Homo sapiens 64-73 12603854-7 2003 17beta-estradiol and bovine serum albumin-conjugated 17beta-estradiol suppressed interferon-gamma-induced transcription through the interferon-stimulated response element and signal transducer and activator of transcription 1alpha binding to interferon-stimulated response element. Estradiol 53-69 interferon gamma Homo sapiens 81-97 12603854-8 2003 17beta-estradiol and bovine serum albumin-conjugated 17beta-estradiol suppressed interferon-gamma-induced tyrosine phosphorylation of signal transducer and activator of transcription 1alpha, and Janus tyrosine kinase 1 and 2. Estradiol 0-16 interferon gamma Homo sapiens 81-97 12603854-8 2003 17beta-estradiol and bovine serum albumin-conjugated 17beta-estradiol suppressed interferon-gamma-induced tyrosine phosphorylation of signal transducer and activator of transcription 1alpha, and Janus tyrosine kinase 1 and 2. Estradiol 53-69 interferon gamma Homo sapiens 81-97 12603854-8 2003 17beta-estradiol and bovine serum albumin-conjugated 17beta-estradiol suppressed interferon-gamma-induced tyrosine phosphorylation of signal transducer and activator of transcription 1alpha, and Janus tyrosine kinase 1 and 2. Tyrosine 106-114 interferon gamma Homo sapiens 81-97 12603854-9 2003 17beta-estradiol-mediated suppression on the interferon-gamma-induced signal transducer and activator of transcription 1alpha activation and interferon-induced protein of 10 kDa synthesis was counteracted by adenylate cyclase inhibitor SQ22536. Estradiol 0-16 interferon gamma Homo sapiens 45-61 12603854-12 2003 These results suggest that 17beta-estradiol may interact with the membrane receptor on keratinocytes and generate 3",5"-adenosine cyclic monophosphate by activating adenylate cyclase, which may lead to the inhibition of interferon-gamma-induced signal transducer and activator of transcription 1alpha activation and interferon-induced protein of 10 kDa synthesis. Estradiol 27-43 interferon gamma Homo sapiens 220-236 12603854-12 2003 These results suggest that 17beta-estradiol may interact with the membrane receptor on keratinocytes and generate 3",5"-adenosine cyclic monophosphate by activating adenylate cyclase, which may lead to the inhibition of interferon-gamma-induced signal transducer and activator of transcription 1alpha activation and interferon-induced protein of 10 kDa synthesis. 3",5"-adenosine cyclic monophosphate 114-150 interferon gamma Homo sapiens 220-236 12710743-1 2003 Unfolding/folding transitions of recombinant human interferon-gamma (hIFNgamma) in urea and guanidine chloride (Gn.HCl) solutions were studied by fluorescence spectroscopy. Urea 83-87 interferon gamma Homo sapiens 51-67 12588972-5 2003 A minimal, 29-nucleotide (nt) element was determined by gel shift assay to be sufficient for maximal binding of the IFN-gamma-activated inhibitor of translation (GAIT), an as-yet-unidentified protein or complex. 29-nucleotide 11-24 interferon gamma Homo sapiens 116-125 12588972-5 2003 A minimal, 29-nucleotide (nt) element was determined by gel shift assay to be sufficient for maximal binding of the IFN-gamma-activated inhibitor of translation (GAIT), an as-yet-unidentified protein or complex. nt 26-28 interferon gamma Homo sapiens 116-125 12926552-4 2003 In contrast to betulin, betulinic acid is a modulator of cytokine production by Th1/Th2 cell subpopulations which slightly enhances IL-10 formation and inhibits IFN-gamma production, reducing IFN-gamma/IL-10 ratio from 3.6 to 2.6. betulinic acid 24-38 interferon gamma Homo sapiens 161-170 12926552-4 2003 In contrast to betulin, betulinic acid is a modulator of cytokine production by Th1/Th2 cell subpopulations which slightly enhances IL-10 formation and inhibits IFN-gamma production, reducing IFN-gamma/IL-10 ratio from 3.6 to 2.6. betulinic acid 24-38 interferon gamma Homo sapiens 192-201 12710743-1 2003 Unfolding/folding transitions of recombinant human interferon-gamma (hIFNgamma) in urea and guanidine chloride (Gn.HCl) solutions were studied by fluorescence spectroscopy. Urea 83-87 interferon gamma Homo sapiens 69-78 12710743-1 2003 Unfolding/folding transitions of recombinant human interferon-gamma (hIFNgamma) in urea and guanidine chloride (Gn.HCl) solutions were studied by fluorescence spectroscopy. Guanidine 92-110 interferon gamma Homo sapiens 51-67 12710743-1 2003 Unfolding/folding transitions of recombinant human interferon-gamma (hIFNgamma) in urea and guanidine chloride (Gn.HCl) solutions were studied by fluorescence spectroscopy. Guanidine 92-110 interferon gamma Homo sapiens 69-78 12710743-1 2003 Unfolding/folding transitions of recombinant human interferon-gamma (hIFNgamma) in urea and guanidine chloride (Gn.HCl) solutions were studied by fluorescence spectroscopy. Hydrochloric Acid 115-118 interferon gamma Homo sapiens 51-67 12710743-4 2003 Both the pH dependence of the fluorescence intensity and the unfolding experiments in urea at variable pH showed that hIFNgamma remains native in the pH range of 4.8-9.5. Urea 86-90 interferon gamma Homo sapiens 118-127 12788307-5 2003 In addition, 15ng/ml of prolactin reversed hydrocortisone suppressive effect on IFN-gamma, IL-12 p70, and IL-10 production in PHA+LPS-stimulated whole blood. Hydrocortisone 43-57 interferon gamma Homo sapiens 80-89 12589163-8 2003 Alloreactive T cells stimulated with DCs pretreated with LPS in the presence of NAL produced much less interferon-gamma but similar levels of interleukin-13 compared with DCs treated with LPS alone. N-acetylcysteine lysinate 80-83 interferon gamma Homo sapiens 103-119 12393527-10 2003 Reduction of FLIP expression with antisense oligonucleotides decreased the capacity of SCF to inhibit IFNgamma-induced apoptosis, demonstrating a definite role for FLIP in the SCF-induced protection of ECFCs from IFNgamma-initiated apoptosis. Oligonucleotides 44-60 interferon gamma Homo sapiens 102-110 12393527-10 2003 Reduction of FLIP expression with antisense oligonucleotides decreased the capacity of SCF to inhibit IFNgamma-induced apoptosis, demonstrating a definite role for FLIP in the SCF-induced protection of ECFCs from IFNgamma-initiated apoptosis. Oligonucleotides 44-60 interferon gamma Homo sapiens 213-221 12574394-6 2003 Although cytotoxicity mediated by perforin-expressing CD4+ CTLs was almost completely inhibited by concanamycin A, a potent inhibitor of the perforin-mediated cytotoxic pathway, cytotoxicity against IFN-gamma-treated keratinocytes mediated by perforin-deficient CD4+ T lymphocytes was inhibited only partially by concanamycin A, but was inhibited significantly by antagonistic anti-Fas Ab and anti-Fas ligand Ab. concanamycin A 99-113 interferon gamma Homo sapiens 199-208 12446674-9 2003 A functional correlation between IFN-gamma and YB-1 was further supported by luciferase assays using four tandem repeats of the Y-box consensus oligonucleotide linked to a minimal promoter. Oligonucleotides 144-159 interferon gamma Homo sapiens 33-42 12599093-3 2003 CSBG also suppressed the release of type 1 cytokines, IL-2, and interferon-gamma. csbg 0-4 interferon gamma Homo sapiens 64-80 12562387-9 2003 By in vitro bioassay, BP inhibited the ability of IFN-gamma but not IL-1beta or TNF-alpha to induce CD54 expression on epithelial cells. Penicillin G 22-24 interferon gamma Homo sapiens 50-59 12562386-0 2003 Atorvastatin suppresses interferon-gamma -induced neopterin formation and tryptophan degradation in human peripheral blood mononuclear cells and in monocytic cell lines. Atorvastatin 0-12 interferon gamma Homo sapiens 24-40 12562386-0 2003 Atorvastatin suppresses interferon-gamma -induced neopterin formation and tryptophan degradation in human peripheral blood mononuclear cells and in monocytic cell lines. Neopterin 50-59 interferon gamma Homo sapiens 24-40 12562386-6 2003 Also in monocytic cell lines THP-1 and MonoMac6, atorvastatin was able to suppress IFN-gamma- and LPS-induced formation of neopterin and degradation of tryptophan. monomac6 39-47 interferon gamma Homo sapiens 83-92 12562386-6 2003 Also in monocytic cell lines THP-1 and MonoMac6, atorvastatin was able to suppress IFN-gamma- and LPS-induced formation of neopterin and degradation of tryptophan. Atorvastatin 49-61 interferon gamma Homo sapiens 83-92 12562386-6 2003 Also in monocytic cell lines THP-1 and MonoMac6, atorvastatin was able to suppress IFN-gamma- and LPS-induced formation of neopterin and degradation of tryptophan. Neopterin 123-132 interferon gamma Homo sapiens 83-92 12562386-6 2003 Also in monocytic cell lines THP-1 and MonoMac6, atorvastatin was able to suppress IFN-gamma- and LPS-induced formation of neopterin and degradation of tryptophan. Tryptophan 152-162 interferon gamma Homo sapiens 83-92 12562386-8 2003 In addition we demonstrate that atorvastatin directly inhibits IFN-gamma-mediated pathways in monocytic cells, suggesting that both immunoreactivity of T cells and of monocyte-derived macrophages are down-regulated by this statin. Atorvastatin 32-44 interferon gamma Homo sapiens 63-72 12562387-0 2003 Benzylpenicillin differentially conjugates to IFN-gamma, TNF-alpha, IL-1beta, IL-4 and IL-13 but selectively reduces IFN-gamma activity. Penicillin G 0-16 interferon gamma Homo sapiens 46-55 12562387-12 2003 BP retained its inhibitory effect on IFN-gamma activity when 20% FCS was added to the pre-incubation medium. Penicillin G 0-2 interferon gamma Homo sapiens 37-46 12562387-0 2003 Benzylpenicillin differentially conjugates to IFN-gamma, TNF-alpha, IL-1beta, IL-4 and IL-13 but selectively reduces IFN-gamma activity. Penicillin G 0-16 interferon gamma Homo sapiens 117-126 12562387-3 2003 We have previously shown that the beta-lactam antibiotic benzylpenicillin (BP) conjugates to IFN-gamma and reduces its activity. beta-Lactams 34-45 interferon gamma Homo sapiens 93-102 12581192-0 2003 Diaminofluorene stain detects erythroid differentiation in immature haemopoietic cells treated with EPO, IL-3, SCF, TGFbeta1, MIP-1alpha and IFNgamma. Diaminofluorene 0-15 interferon gamma Homo sapiens 141-149 12562387-3 2003 We have previously shown that the beta-lactam antibiotic benzylpenicillin (BP) conjugates to IFN-gamma and reduces its activity. Penicillin G 57-73 interferon gamma Homo sapiens 93-102 12562387-3 2003 We have previously shown that the beta-lactam antibiotic benzylpenicillin (BP) conjugates to IFN-gamma and reduces its activity. Penicillin G 75-77 interferon gamma Homo sapiens 93-102 12562325-4 2003 The addition of increasing amounts of allergen during DC maturation with tumour necrosis factor-alpha, IL-1beta and prostaglandin E2 resulted in enhanced secretion of IL-6 and IL-12 by DC followed by increased production of Th1 (interferon-gamma; IFN-gamma) as well as Th2 (IL-4, IL-5) cytokines by CD4+ T cells. Dinoprostone 116-132 interferon gamma Homo sapiens 229-245 12604404-7 2003 Furthermore, addition of caspase-inhibitors or anti-TNFalpha/-IFNgamma monoclonal antibodies to fludarabine-treated cells allowed us to determine the mediators of apoptosis. fludarabine 96-107 interferon gamma Homo sapiens 62-70 12604404-13 2003 Moreover, upregulation of TNFRI/II, release of TNFalpha and IFNgamma, and inhibition of apoptosis by anti-TNFalpha/-IFNgamma monoclonal antibodies in CD40-activated cells strongly suggest that these cytokines may play a role in sensitizing B-cells to fludarabine treatment. fludarabine 251-262 interferon gamma Homo sapiens 116-124 12675200-5 2003 OCE significantly inhibited the production of TNF-alpha, IL-1beta and interferon-gamma (INF-gamma), compared to absence of OCE. oce 0-3 interferon gamma Homo sapiens 70-86 12675200-5 2003 OCE significantly inhibited the production of TNF-alpha, IL-1beta and interferon-gamma (INF-gamma), compared to absence of OCE. oce 0-3 interferon gamma Homo sapiens 88-97 12562325-4 2003 The addition of increasing amounts of allergen during DC maturation with tumour necrosis factor-alpha, IL-1beta and prostaglandin E2 resulted in enhanced secretion of IL-6 and IL-12 by DC followed by increased production of Th1 (interferon-gamma; IFN-gamma) as well as Th2 (IL-4, IL-5) cytokines by CD4+ T cells. Dinoprostone 116-132 interferon gamma Homo sapiens 247-256 12494456-9 2003 Examining the effect of a major product of COX 1 in an in vitro system of human colonic epithelial monolayers, prostaglandin E(2) (PGE(2)) in low concentration (10(-6) M) enhanced epithelial barrier function and partially protected epithelia from the barrier-disruptive consequences of a pro-inflammatory cytokine, IFN-gamma. Prostaglandins E 111-126 interferon gamma Homo sapiens 315-324 12683414-6 2003 PMDD immunisation induced a frequency of 168YPHFMPTNL176-specific interferon-gamma (IFN-gamma)-secreting splenocytes, which was equivalent to that after K181 infection and significantly higher than tsm immunisation. pmdd 0-4 interferon gamma Homo sapiens 66-82 12673070-4 2003 RESULTS: Serum IFN-gamma and GM-CSF levels were significantly related to levels of methacholine airway responsiveness among nonasthmatics in this population. Methacholine Chloride 83-95 interferon gamma Homo sapiens 15-24 12673070-6 2003 Both serum IFN-gamma and GM-CSF levels were also significantly related to the log dose-response slope for methacholine responsiveness. Methacholine Chloride 106-118 interferon gamma Homo sapiens 11-20 12538816-6 2003 In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR. salbutanol 20-30 interferon gamma Homo sapiens 202-218 12538816-6 2003 In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR. Terbutaline 35-46 interferon gamma Homo sapiens 202-218 12538816-6 2003 In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR. Norepinephrine 58-72 interferon gamma Homo sapiens 202-218 25897650-11 2015 Activation of IRF-1 by TNF-alpha/IFN-gamma was inhibited by CpdA. CPDA 60-64 interferon gamma Homo sapiens 33-42 12538816-6 2003 In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR. Epinephrine 61-72 interferon gamma Homo sapiens 202-218 12538816-6 2003 In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR. Isoproterenol 91-104 interferon gamma Homo sapiens 202-218 12610507-4 2003 Annexin V binding to CD8(+) T cells and PMA/ionomycin-induced IFN-gamma expression were also evaluated in patients and NC. Ionomycin 44-53 interferon gamma Homo sapiens 62-71 12517959-6 2003 EGR-1 overexpression or treatment with monokine induced by IFN-gamma resulted in a ROS-dependent inhibition of basolateral Na(+)/K(+)-ATPase activity, compromising sodium transport in these cells. Reactive Oxygen Species 83-86 interferon gamma Homo sapiens 59-68 12535832-7 2003 RESULTS: Carvedilol improved the 14-day survival of the animals, attenuated myocardial lesions on day 7, and increased myocardial levels of interleukin (IL)-12 and interferon (IFN)-gamma, whereas reducing myocardial virus replication. Carvedilol 9-19 interferon gamma Homo sapiens 164-186 12535832-8 2003 Propranolol also attenuated myocardial lesions, but to a lesser extent, and increased IL-12 and IFN-gamma levels. Propranolol 0-11 interferon gamma Homo sapiens 96-105 12535832-11 2003 CONCLUSIONS: These results suggest that by blocking the beta(2)-stimulating effects of catecholamines, carvedilol exerts some of its beneficial effects by increasing the production of IL-12 and IFN-gamma. Catecholamines 87-101 interferon gamma Homo sapiens 194-203 12535832-11 2003 CONCLUSIONS: These results suggest that by blocking the beta(2)-stimulating effects of catecholamines, carvedilol exerts some of its beneficial effects by increasing the production of IL-12 and IFN-gamma. Carvedilol 103-113 interferon gamma Homo sapiens 194-203 12535832-12 2003 Carvedilol may be effective in patients with viral myocarditis by boosting IL-12 and IFN-gamma production. Carvedilol 0-10 interferon gamma Homo sapiens 85-94 12507852-8 2003 A significant increase in IFN-gamma positive cells was found at 7 DPI (15.90+/-13.65%), 10 DPI (46.95+/-13.79%), 14 DPI (10.90+/-5.13%) and 28 DPI (13.40+/-4.89%) in the HV group (P<0.05). 3-aminodiphenyleneiodium 66-69 interferon gamma Homo sapiens 26-35 12507852-8 2003 A significant increase in IFN-gamma positive cells was found at 7 DPI (15.90+/-13.65%), 10 DPI (46.95+/-13.79%), 14 DPI (10.90+/-5.13%) and 28 DPI (13.40+/-4.89%) in the HV group (P<0.05). 3-aminodiphenyleneiodium 91-94 interferon gamma Homo sapiens 26-35 12507852-8 2003 A significant increase in IFN-gamma positive cells was found at 7 DPI (15.90+/-13.65%), 10 DPI (46.95+/-13.79%), 14 DPI (10.90+/-5.13%) and 28 DPI (13.40+/-4.89%) in the HV group (P<0.05). 3-aminodiphenyleneiodium 91-94 interferon gamma Homo sapiens 26-35 12507852-8 2003 A significant increase in IFN-gamma positive cells was found at 7 DPI (15.90+/-13.65%), 10 DPI (46.95+/-13.79%), 14 DPI (10.90+/-5.13%) and 28 DPI (13.40+/-4.89%) in the HV group (P<0.05). 3-aminodiphenyleneiodium 91-94 interferon gamma Homo sapiens 26-35 12475762-7 2003 The combined application of the Ca(2+) ionophore ionomycin (1 microg/ml) and the phorbol ester phorbol 12-myristate 13-acetate (PMA; 5 microg/ml) stimulated IFN-gamma production, an effect again reversed by hyperosmolarity. Ionomycin 49-58 interferon gamma Homo sapiens 157-166 12475762-7 2003 The combined application of the Ca(2+) ionophore ionomycin (1 microg/ml) and the phorbol ester phorbol 12-myristate 13-acetate (PMA; 5 microg/ml) stimulated IFN-gamma production, an effect again reversed by hyperosmolarity. Phorbol Esters 81-94 interferon gamma Homo sapiens 157-166 12475762-7 2003 The combined application of the Ca(2+) ionophore ionomycin (1 microg/ml) and the phorbol ester phorbol 12-myristate 13-acetate (PMA; 5 microg/ml) stimulated IFN-gamma production, an effect again reversed by hyperosmolarity. Tetradecanoylphorbol Acetate 95-126 interferon gamma Homo sapiens 157-166 12475762-7 2003 The combined application of the Ca(2+) ionophore ionomycin (1 microg/ml) and the phorbol ester phorbol 12-myristate 13-acetate (PMA; 5 microg/ml) stimulated IFN-gamma production, an effect again reversed by hyperosmolarity. Tetradecanoylphorbol Acetate 128-131 interferon gamma Homo sapiens 157-166 14680506-7 2003 Elevation of intracellular cAMP, on the other hand, potently suppressed macrophage TNF-alpha production and modulated T-cell response by inhibiting TNF-alpha and IFN-gamma. Cyclic AMP 27-31 interferon gamma Homo sapiens 162-171 12223098-5 2003 These responses to IFN-gamma were blocked by overexpression of the JAK inhibitor, JAK-binding protein (JAB), or reversed by dominant-negative Stat1 alpha Y701F containing a mutation at Tyr-701, the JAK phosphorylation site. Tyrosine 185-188 interferon gamma Homo sapiens 19-28 12784048-0 2003 A switch to high-flux helixone membranes reverses suppressed interferon-gamma production in patients on low-flux dialysis. helixone 22-30 interferon gamma Homo sapiens 61-77 12600410-0 2003 Modulation of interleukin-8 and nitric oxide synthase mRNA levels by interferon-gamma in macrophages stimulated with lignin derivatives and lipopolysaccharides. Lignin 117-123 interferon gamma Homo sapiens 69-85 12600410-1 2003 It has been shown that interferon-gamma (IFN-gamma) plays a role in the regulation of interleukin-8 (IL-8), nitric oxide (NO), and tumor necrosis factor-alpha (TNF-alpha) secretion by macrophages stimulated with lignin derivatives, such as EP3, and lipopolysaccharides (LPS) [Cytokine 11 (1999) 571]. Nitric Oxide 108-120 interferon gamma Homo sapiens 23-39 12600410-1 2003 It has been shown that interferon-gamma (IFN-gamma) plays a role in the regulation of interleukin-8 (IL-8), nitric oxide (NO), and tumor necrosis factor-alpha (TNF-alpha) secretion by macrophages stimulated with lignin derivatives, such as EP3, and lipopolysaccharides (LPS) [Cytokine 11 (1999) 571]. Nitric Oxide 108-120 interferon gamma Homo sapiens 41-50 12600410-1 2003 It has been shown that interferon-gamma (IFN-gamma) plays a role in the regulation of interleukin-8 (IL-8), nitric oxide (NO), and tumor necrosis factor-alpha (TNF-alpha) secretion by macrophages stimulated with lignin derivatives, such as EP3, and lipopolysaccharides (LPS) [Cytokine 11 (1999) 571]. Lignin 212-218 interferon gamma Homo sapiens 23-39 12600410-1 2003 It has been shown that interferon-gamma (IFN-gamma) plays a role in the regulation of interleukin-8 (IL-8), nitric oxide (NO), and tumor necrosis factor-alpha (TNF-alpha) secretion by macrophages stimulated with lignin derivatives, such as EP3, and lipopolysaccharides (LPS) [Cytokine 11 (1999) 571]. Lignin 212-218 interferon gamma Homo sapiens 41-50 14579932-7 2003 PBMEC stimulated with the supernatant of phytohemagglutinin-activated porcine peripheral blood mononuclear cells or porcine IFN-gamma, but not nonstimulated PBMEC, induced proliferation of both CD8 and CD4 T cells as assessed by [3H]thymidine incorporation. Tritium 230-232 interferon gamma Homo sapiens 124-133 14579932-7 2003 PBMEC stimulated with the supernatant of phytohemagglutinin-activated porcine peripheral blood mononuclear cells or porcine IFN-gamma, but not nonstimulated PBMEC, induced proliferation of both CD8 and CD4 T cells as assessed by [3H]thymidine incorporation. Thymidine 233-242 interferon gamma Homo sapiens 124-133 12527624-5 2003 IFN-gamma is emerging as an important cytokine for use in the treatment of patients with infectious diseases, including multidrug-resistant pulmonary TB. Terbium 150-152 interferon gamma Homo sapiens 0-9 12534554-6 2003 RESULTS: A significantly lower ratio of IFN-gamma-/IL-4-producing CD4+ T cells after phorbol 12-myristate acetate/ionomycin stimulation was found in patients with atopic cough and atopic asthma compared with normal subjects. phorbol 12-myristate acetate 85-113 interferon gamma Homo sapiens 40-49 12534554-6 2003 RESULTS: A significantly lower ratio of IFN-gamma-/IL-4-producing CD4+ T cells after phorbol 12-myristate acetate/ionomycin stimulation was found in patients with atopic cough and atopic asthma compared with normal subjects. Ionomycin 114-123 interferon gamma Homo sapiens 40-49 12538455-11 2003 IFN-gamma induced significant but short-lived up-regulation of surrogate markers of monocyte activation (serum neopterin) and class I up-regulation (serum beta-2-microglobulin) in most patients. Neopterin 111-120 interferon gamma Homo sapiens 0-9 12871184-6 2003 Moreover, unacceptable toxicity resulting from IFN gamma overproduction was observed in 2 renal carcinoma patients included in a phase II clinical trial that consisted in systemic administration of rIL-12. ril-12 198-204 interferon gamma Homo sapiens 47-56 15719622-6 2003 After surgery, chemotherapy for 3 cycles and oral vitamin-A, a sharp reduction in telomerase activity and serum IFN-gamma levels was observed in all groups of patients compared to the controls. Vitamin A 50-59 interferon gamma Homo sapiens 112-121 15719622-10 2003 In contrast, negative correlations were observed between serum levels of vitamin-A and telomerase activity and serum levels of IFN-gamma (P < 0.01). Vitamin A 73-82 interferon gamma Homo sapiens 127-136 12594832-4 2003 Pretreatment of NK cells with the phosphatidylinositol 3-kinase (PI 3-K) inhibitor, wortmannin, completely inhibited the production of IFN-gamma induced by fractalkine, and pretreatment with the protein tyrosine kinase inhibitor, herbimycin A, partially suppressed the response, suggesting that augmentation of IFN-gamma production in response to fractalkine treatment of NK cells involves signaling through PI 3-K and protein tyrosine kinases. Wortmannin 84-94 interferon gamma Homo sapiens 135-144 12594832-4 2003 Pretreatment of NK cells with the phosphatidylinositol 3-kinase (PI 3-K) inhibitor, wortmannin, completely inhibited the production of IFN-gamma induced by fractalkine, and pretreatment with the protein tyrosine kinase inhibitor, herbimycin A, partially suppressed the response, suggesting that augmentation of IFN-gamma production in response to fractalkine treatment of NK cells involves signaling through PI 3-K and protein tyrosine kinases. Wortmannin 84-94 interferon gamma Homo sapiens 311-320 12594832-4 2003 Pretreatment of NK cells with the phosphatidylinositol 3-kinase (PI 3-K) inhibitor, wortmannin, completely inhibited the production of IFN-gamma induced by fractalkine, and pretreatment with the protein tyrosine kinase inhibitor, herbimycin A, partially suppressed the response, suggesting that augmentation of IFN-gamma production in response to fractalkine treatment of NK cells involves signaling through PI 3-K and protein tyrosine kinases. herbimycin 230-242 interferon gamma Homo sapiens 135-144 12436477-5 2003 The effect of ribavirin on IFN-gamma and IL-1beta release in the supernatant of unstimulated and phytohemagglutinin (PHA) stimulated PBMCs was investigated by enzyme linked immunosorbent assay (ELISA). Ribavirin 14-23 interferon gamma Homo sapiens 27-36 12436477-7 2003 Ribavirin led to a dose-dependent decrease of the IFN-gamma but an increase of IL-1beta release into the supernatant of PHA-stimulated PBMCs. Ribavirin 0-9 interferon gamma Homo sapiens 50-59 12436477-11 2003 Our data suggest that ribavirin administration to chronically HCV-infected patients could lead to a decrease of the synthesis of proinflammatory cytokines (e.g., IFN-gamma) by an inhibition of total DNA-, RNA-, and protein-synthesis and by induction of apoptosis in the cells of the inflammatory infiltrate. Ribavirin 22-31 interferon gamma Homo sapiens 162-171 12502840-4 2003 Notably, multiple components of the immunoproteasome and ubiquitin-like proteins were strongly induced by both IFN-alpha/beta and IFN-gamma, as were a number of GTP-binding proteins, including GTPases with known antiviral activity, chemokines, signaling molecules, and miscellaneous genes associated with antigen processing, DNA-binding, or cochaperone activity and several expressed sequence tags. Guanosine Triphosphate 161-164 interferon gamma Homo sapiens 130-139 14587429-0 2003 [Effect of IFN-gamma on IGE dependent leukotriene generation by peripheral blood leukocytes in patients with chronic allergic rhinitis in vitro]. Leukotrienes 38-49 interferon gamma Homo sapiens 11-20 14587429-4 2003 The aim of this study was to investigate the influence of IFN-gamma on leukotriene C4 (LTC4) production by peripheral blood leukocytes isolated from the patients suffering from perennial allergic rhinitis caused by allergy to mites. Leukotriene C4 71-85 interferon gamma Homo sapiens 58-67 12804014-1 2003 Human macrophages release the pterin, 7,8-dihydroneopterin when exposed to the immune stimulant gamma-interferon (IFN-gamma). Pterins 30-36 interferon gamma Homo sapiens 114-123 12804014-1 2003 Human macrophages release the pterin, 7,8-dihydroneopterin when exposed to the immune stimulant gamma-interferon (IFN-gamma). 7,8-dihydroneopterin 38-58 interferon gamma Homo sapiens 114-123 12804014-5 2003 The extracellular pterin concentration increased from 0 to 16 nM with IFN-gamma stimulation, while the intracellular concentration increased from 0.21 to 1.69 nmol/mg cell protein. Pterins 18-24 interferon gamma Homo sapiens 70-79 12505703-3 2002 Exposure of human T-cells to THC suppresses their proliferation, inhibits the release of interferon-gamma, and skews the balance of T-helper cytokines towards a type 2 response. Dronabinol 29-32 interferon gamma Homo sapiens 89-105 12526087-5 2002 Results show that lovastatin suppresses expression of ICAM-1 by inhibiting the IFN-gamma-induced extracellular signal-regulated kinase (ERK) p44/p42-STAT1 signaling pathway. Lovastatin 18-28 interferon gamma Homo sapiens 79-88 12526087-6 2002 In cells treated with lovastatin and IFN-gamma, ICAM-1 was expressed at a lower level than in cells treated with IFN-gamma alone. Lovastatin 22-32 interferon gamma Homo sapiens 113-122 12526087-11 2002 But lovastatin does inhibit the IFN-gamma-mediated phosphorylation of ERK1/ERK2 (T202/Y204) and S727 phosphorylation of STAT1. Lovastatin 4-14 interferon gamma Homo sapiens 32-41 12379662-1 2002 We determined whether salicylate at pharmacological concentrations inhibits nitric-oxide synthase-2 (NOS-2) and cyclo-oxygenase-2 (COX-2) expressions in RAW 264.7 stimulated with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma). Salicylates 22-32 interferon gamma Homo sapiens 208-224 12379662-1 2002 We determined whether salicylate at pharmacological concentrations inhibits nitric-oxide synthase-2 (NOS-2) and cyclo-oxygenase-2 (COX-2) expressions in RAW 264.7 stimulated with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma). Salicylates 22-32 interferon gamma Homo sapiens 226-235 12504574-6 2002 In contrast, complete inhibition of HLA-class I expression on monocytes/macrophages occurred only when vIL-10 was present 2 h prior to the addition of IFN-gamma, implying that vIL-10 affects an early step in the IFN-gamma signaling pathway. vil-10 176-182 interferon gamma Homo sapiens 212-221 12633570-6 2002 Taken together, these findings suggest that IFN-gamma potentiates Fas- and TRAIL-mediated apoptosis by increasing caspase-8 expression via an IFN-gamma response element in A549 cells. ammonium ferrous sulfate 66-69 interferon gamma Homo sapiens 44-53 12633570-6 2002 Taken together, these findings suggest that IFN-gamma potentiates Fas- and TRAIL-mediated apoptosis by increasing caspase-8 expression via an IFN-gamma response element in A549 cells. ammonium ferrous sulfate 66-69 interferon gamma Homo sapiens 142-151 12431781-0 2002 The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Flavonoids 4-13 interferon gamma Homo sapiens 51-66 12431781-0 2002 The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Quercetin 15-24 interferon gamma Homo sapiens 51-66 12431781-7 2002 Quercetin significantly induces the gene expression as well as the production of Th-1 derived IFNgamma and the downregulates Th-2 derived IL-4 by normal PBMC. Quercetin 0-9 interferon gamma Homo sapiens 94-102 12431781-8 2002 Further, quercetin treatment increased the phenotypic expression of IFNgamma cells and decreased IL-4 positive cells by FACS analysis, which corroborate with protein secretion and gene expression studies. Quercetin 9-18 interferon gamma Homo sapiens 68-76 12431781-9 2002 These results suggest that the beneficial immuno-stimulatory effects of quercetin may be mediated through the induction of Th-1 derived cytokine, IFNgamma, and inhibition of Th-2 derived cytokine, IL-4. Quercetin 72-81 interferon gamma Homo sapiens 146-154 12393638-6 2002 Steroid treatment was found to suppress Aspergillus-specific lymphoproliferation (P =.037) and release of IFN-gamma in culture supernatants (P =.017). Steroids 0-7 interferon gamma Homo sapiens 106-115 12393684-6 2002 Moreover, we found that the release of IFN-gamma by T lymphocytes was reduced in presence of both HMCLs and purified MM cells. hmcls 98-103 interferon gamma Homo sapiens 39-48 12459177-3 2002 The activity of nuclear STAT1 following stimulation with IFN-gamma was sustained with the phosphatase inhibitor, pervanadate, or the proteasome inhibitor, lactacystin. pervanadate 113-124 interferon gamma Homo sapiens 57-66 12459177-3 2002 The activity of nuclear STAT1 following stimulation with IFN-gamma was sustained with the phosphatase inhibitor, pervanadate, or the proteasome inhibitor, lactacystin. lactacystin 155-166 interferon gamma Homo sapiens 57-66 12657248-6 2002 Furthermore, IL-2, IL-4, IL-5, and IFN-gamma secretion by Hut 78 cells or CD3(+) T cells stimulated with PMA plus ionomycin or anti-CD3 antibody plus PMA were inhibited in a concentration-dependent manner by BTPs. Tetradecanoylphorbol Acetate 105-108 interferon gamma Homo sapiens 35-44 12657248-6 2002 Furthermore, IL-2, IL-4, IL-5, and IFN-gamma secretion by Hut 78 cells or CD3(+) T cells stimulated with PMA plus ionomycin or anti-CD3 antibody plus PMA were inhibited in a concentration-dependent manner by BTPs. Ionomycin 114-123 interferon gamma Homo sapiens 35-44 12657248-6 2002 Furthermore, IL-2, IL-4, IL-5, and IFN-gamma secretion by Hut 78 cells or CD3(+) T cells stimulated with PMA plus ionomycin or anti-CD3 antibody plus PMA were inhibited in a concentration-dependent manner by BTPs. Tetradecanoylphorbol Acetate 150-153 interferon gamma Homo sapiens 35-44 12657248-6 2002 Furthermore, IL-2, IL-4, IL-5, and IFN-gamma secretion by Hut 78 cells or CD3(+) T cells stimulated with PMA plus ionomycin or anti-CD3 antibody plus PMA were inhibited in a concentration-dependent manner by BTPs. btps 208-212 interferon gamma Homo sapiens 35-44 12493070-2 2002 A similar change in the rate of oxygen consumption is observed when Caco-2 human enterocyte-like cells are incubated in vitro with cytomix, a cocktail of cytokines containing tumor necrosis factor, IL-1beta, and IFN-gamma. Oxygen 32-38 interferon gamma Homo sapiens 212-221 12480581-6 2002 CONCLUSION: Fas-mediated apoptosis is one of the mechanisms for IFN-gamma to exercise its anti-tumor effect. ammonium ferrous sulfate 12-15 interferon gamma Homo sapiens 64-73 12473063-5 2002 Furthermore, in supernatants from whole blood samples stimulated with phorbol 12-myristate 13-acetate and ionomycin, production of IFN-gamma was significantly decreased, while IL-4 production remained unchanged in AD patients compared with healthy controls. Tetradecanoylphorbol Acetate 70-101 interferon gamma Homo sapiens 131-140 12473063-5 2002 Furthermore, in supernatants from whole blood samples stimulated with phorbol 12-myristate 13-acetate and ionomycin, production of IFN-gamma was significantly decreased, while IL-4 production remained unchanged in AD patients compared with healthy controls. Ionomycin 106-115 interferon gamma Homo sapiens 131-140 12486207-7 2002 Tumor necrosis factor-alpha and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 195-205 interferon gamma Homo sapiens 32-41 12406386-4 2002 We herein report that 15-deoxy-n12,14 -prostaglandinJ2 (15d-PGJ2), a PPAR-gamma agonist,inhibits the expression of fractalkine induced by IFN-gamma orIL-1beta in human endothelial cells. 15-deoxy-n12,14 -prostaglandinj2 22-54 interferon gamma Homo sapiens 138-158 12406386-4 2002 We herein report that 15-deoxy-n12,14 -prostaglandinJ2 (15d-PGJ2), a PPAR-gamma agonist,inhibits the expression of fractalkine induced by IFN-gamma orIL-1beta in human endothelial cells. 15-deoxyprostaglandin J2 56-64 interferon gamma Homo sapiens 138-158 12406386-6 2002 15-Deoxy-D12,14 prostaglandinJ2 also inhibited the adhesion of blood mononuclear cellsto endothelial monolayers treated with IFN-gamma or IL-1beta. 15-deoxy-d12 0-12 interferon gamma Homo sapiens 125-134 12406386-6 2002 15-Deoxy-D12,14 prostaglandinJ2 also inhibited the adhesion of blood mononuclear cellsto endothelial monolayers treated with IFN-gamma or IL-1beta. 14 prostaglandinj2 13-31 interferon gamma Homo sapiens 125-134 12460198-6 2002 By contrast, CBP-bound rPhl p 5b, but not rPhl p 5b alone or coadministered with CBP, induced a mixed allergen-specific T helper 1 (Th1)/Th2 immune response characterized by the additional production of allergen-specific IgG2a/b antibody responses and elevated interferon-gamma production. 4,4'-Bis(N-carbazolyl)-1,1'-biphenyl 13-16 interferon gamma Homo sapiens 261-277 12466036-10 2002 Pro-inflammatory cytokines such as IL-1beta, IFN-alpha, IFN-gamma and TNF-alpha affect the 5-HT metabolism directly and/or indirectly by stimulating the enzyme indoleamine 2,3-dioxygenase which leads to a peripheral depletion of tryptophan. Tryptophan 229-239 interferon gamma Homo sapiens 56-65 12423273-9 2002 Phenylmethylsulfonyl fluoride significantly inhibited shedding of sTNF-R and a synergistic effect of TNF and IFN-gamma on apoptosis was observed. Phenylmethylsulfonyl Fluoride 0-29 interferon gamma Homo sapiens 109-118 12444115-1 2002 We recently reported that the direct antitumor effectors in the liver induced by alpha-galactosylceramide (alpha-GalCer) are NK cells that are activated by the IFN-gamma produced from NK1.1 Ag(+) T cells (NKT cells) specifically stimulated with alpha-GalCer, whereas NKT cells cause hepatocyte injury through the Fas-Fas ligand pathway. alpha-galactosylceramide 81-105 interferon gamma Homo sapiens 160-169 12444145-9 2002 The percentage and absolute number of Gag-specific IFN-gamma(+)IL-2(+) but not of IFN-gamma(+)IL-2(-) CD4s correlated inversely with virus load. Glycosaminoglycans 38-41 interferon gamma Homo sapiens 51-60 12444145-10 2002 The Gag-specific IFN-gamma(+)IL-2(+) CD4 response also correlated positively with the percentage of Gag-specific IFN-gamma(+) CD8 T cells in these subjects. Glycosaminoglycans 4-7 interferon gamma Homo sapiens 17-26 12444145-10 2002 The Gag-specific IFN-gamma(+)IL-2(+) CD4 response also correlated positively with the percentage of Gag-specific IFN-gamma(+) CD8 T cells in these subjects. Glycosaminoglycans 4-7 interferon gamma Homo sapiens 113-122 12488496-2 2002 Monocytes/macrophages are known to secrete large amounts of neopterin upon stimulation with interferon-gamma (IFN-gamma). Neopterin 60-69 interferon gamma Homo sapiens 92-108 12488496-2 2002 Monocytes/macrophages are known to secrete large amounts of neopterin upon stimulation with interferon-gamma (IFN-gamma). Neopterin 60-69 interferon gamma Homo sapiens 110-119 12488496-7 2002 In response to IFN-gamma, cells significantly increased their output of neopterin. Neopterin 72-81 interferon gamma Homo sapiens 15-24 12581487-7 2002 Tumor necrosis factor-alpha (TNF-alpha) and IFN-gamma cytokine secretion in the 10,000 IU group at month 5 showed a significant decrease that corresponded with the effect of ingested IFN-alpha on decreasing gadolinium enhancements. Gadolinium 207-217 interferon gamma Homo sapiens 44-53 12446015-3 2002 THC suppressed T cell proliferation, inhibited the production of interferon-gamma and shifted the balance of T helper 1 (Th1)/T helper 2 (Th2) cytokines. Dronabinol 0-3 interferon gamma Homo sapiens 65-81 12446015-4 2002 Intracellular cytokine staining demonstrated that THC reduced both the percentage and mean fluorescence intensity of activated T cells capable of producing interferon-gamma, with variable effects on the number of T cells capable of producing interleukin-4. Dronabinol 50-53 interferon gamma Homo sapiens 156-172 12474988-11 2002 Mean GA-TCL IFNgamma production was significantly lower in all treatment groups compared to pretreatment IL-5 levels were enhanced in all treatment groups compared to pretreatment levels, but the change was not statistically significant. ga-tcl 5-11 interferon gamma Homo sapiens 12-20 12457984-4 2002 Both orfvIL-10 and ovIL-10 inhibited TNF-alpha and IL-8 cytokine production from stimulated ovine macrophages and keratinocytes and IFN-gamma and GM-CSF production from peripheral blood lymphocytes. orfvil-10 5-14 interferon gamma Homo sapiens 132-141 12417252-3 2002 In this study, lipopolysaccharide (LPS) and interferon-gamma (IFN-g) were used to stimulate C6 glioma cells in the presence of varying concentrations of L-DOPA (1 microM-1 mM). Levodopa 153-159 interferon gamma Homo sapiens 44-60 12417252-3 2002 In this study, lipopolysaccharide (LPS) and interferon-gamma (IFN-g) were used to stimulate C6 glioma cells in the presence of varying concentrations of L-DOPA (1 microM-1 mM). Levodopa 153-159 interferon gamma Homo sapiens 62-67 12435401-4 2002 Productively stimulated nai;ve T cells expressed IL-2 to differentiate into T helper 1 (Th1) cells, secreting interferon-gamma (IFN-gamma) upon secondary antigen stimulation; T cells primed with an APL did not secrete either interleukin-4 (IL-4) or IFN-gamma, but expressed TGF-beta1 and Tob, a member of the anti-proliferative gene family. Sodium Iodide 24-27 interferon gamma Homo sapiens 128-137 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Polychlorinated Biphenyls 36-40 interferon gamma Homo sapiens 112-128 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Polychlorinated Biphenyls 36-40 interferon gamma Homo sapiens 130-139 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Pentachlorophenol 42-45 interferon gamma Homo sapiens 112-128 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Pentachlorophenol 42-45 interferon gamma Homo sapiens 130-139 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Hexachlorobenzene 47-50 interferon gamma Homo sapiens 112-128 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Hexachlorobenzene 47-50 interferon gamma Homo sapiens 130-139 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Hexachlorocyclohexane 52-56 interferon gamma Homo sapiens 112-128 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Hexachlorocyclohexane 52-56 interferon gamma Homo sapiens 130-139 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Dichlorodiphenyl Dichloroethylene 58-61 interferon gamma Homo sapiens 112-128 12696651-7 2002 The data in this study suggest that PCBs, PCP, HCB, HCHs, DDE, and DDD suppress TH1 cytokines, such as IL-2 and interferon-gamma (IFN-gamma), and induce TH2 cytokines, such as IL-4. Dichlorodiphenyl Dichloroethylene 58-61 interferon gamma Homo sapiens 130-139 12404285-10 2002 CsA added in vitro to patient"s lymphocytes significantly decreased the number of IFN-gamma-expressing CD4(+) cells, but not Fas-L production. Cyclosporine 0-3 interferon gamma Homo sapiens 82-91 12404285-15 2002 The ability of CsA to decrease in vitro IFN-gamma production may improve hematopoietic function, explaining the beneficial effect of this agent in HMDS patients. Cyclosporine 15-18 interferon gamma Homo sapiens 40-49 12508773-3 2002 IL-2, IL-10, and IFN-gamma expression was determined in PMA + ionomycin stimulated T cells on the single cell level. Ionomycin 62-71 interferon gamma Homo sapiens 17-26 12385023-5 2002 Consistent with the diminished IL-12 synthesis, DC stimulated with LPS in presence of Bis were deficient in the induction of IFN-gamma production by allogeneic CD4+ T cells. bisindolylmaleimide 86-89 interferon gamma Homo sapiens 125-134 12484048-10 2002 These results suggest that Fas was expressed, apoptosis was induced by CH-11 and the induction of apoptosis was enhanced by IFN-gamma in human bile duct carcinoma cells. ammonium ferrous sulfate 27-30 interferon gamma Homo sapiens 124-133 12393030-6 2002 The IFN-gamma ratio was significantly lower in the LC group (29.7+/-0.3 vs. 44.2+/-15.0%, P<0.01). Leu-Cys 51-53 interferon gamma Homo sapiens 4-13 12423309-2 2002 In the current study we show that interactions between NO and glutathione (GSH) metabolism are related to the selective persistent inhibition of interferon-gamma (IFN-gamma) production by NO, which we previously identified. Glutathione 62-73 interferon gamma Homo sapiens 145-161 12423309-2 2002 In the current study we show that interactions between NO and glutathione (GSH) metabolism are related to the selective persistent inhibition of interferon-gamma (IFN-gamma) production by NO, which we previously identified. Glutathione 62-73 interferon gamma Homo sapiens 163-172 12423309-2 2002 In the current study we show that interactions between NO and glutathione (GSH) metabolism are related to the selective persistent inhibition of interferon-gamma (IFN-gamma) production by NO, which we previously identified. Glutathione 75-78 interferon gamma Homo sapiens 145-161 12423309-2 2002 In the current study we show that interactions between NO and glutathione (GSH) metabolism are related to the selective persistent inhibition of interferon-gamma (IFN-gamma) production by NO, which we previously identified. Glutathione 75-78 interferon gamma Homo sapiens 163-172 12423309-4 2002 Persistent inhibition of IFN-gamma by Sper was prevented by addition of the GSH precursor l-cysteine, which inhibits Sper induced GSH depletion. Glutathione 76-79 interferon gamma Homo sapiens 25-34 12423309-4 2002 Persistent inhibition of IFN-gamma by Sper was prevented by addition of the GSH precursor l-cysteine, which inhibits Sper induced GSH depletion. Cysteine 90-100 interferon gamma Homo sapiens 25-34 12423309-4 2002 Persistent inhibition of IFN-gamma by Sper was prevented by addition of the GSH precursor l-cysteine, which inhibits Sper induced GSH depletion. Glutathione 130-133 interferon gamma Homo sapiens 25-34 12423309-10 2002 Since NO induced apoptosis selectively affects IFN-gamma production these findings implicate GSH metabolism in the modulation and maintenance of the T helper (Th)1/Th2 balance. Glutathione 93-96 interferon gamma Homo sapiens 47-56 12444324-13 2002 After stimulating with PMA-ionomycin we found significant differences in CD4+ lymphocyte production of IL-4 and IFN-gamma with no differences in CD8+ lymphocyte production of either cytokine. Ionomycin 27-36 interferon gamma Homo sapiens 112-121 12445196-4 2002 NS398 enhanced interferon-gamma-induced IP-10 secretion, mRNA expression, and promoter activation in A431, and exogenous PGE2 antagonized the enhancement. Dinoprostone 121-125 interferon gamma Homo sapiens 15-31 12445196-6 2002 NS398 enhanced interferon-gamma-induced transcription through ISRE and binding of signal transducer and activator of transcription 1alpha (STAT1alpha to ISRE in A431, and PGE2 antagonized the enhancement. Dinoprostone 171-175 interferon gamma Homo sapiens 15-31 12445196-7 2002 NS398 enhanced interferon-gamma-induced tyrosine phosphorylation of STAT1alpha, Janus tyrosine kinase 1, and Janus tyrosine kinase 2, and PGE2 antagonized the enhancement. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 0-5 interferon gamma Homo sapiens 15-31 12445196-7 2002 NS398 enhanced interferon-gamma-induced tyrosine phosphorylation of STAT1alpha, Janus tyrosine kinase 1, and Janus tyrosine kinase 2, and PGE2 antagonized the enhancement. Tyrosine 40-48 interferon gamma Homo sapiens 15-31 12445196-7 2002 NS398 enhanced interferon-gamma-induced tyrosine phosphorylation of STAT1alpha, Janus tyrosine kinase 1, and Janus tyrosine kinase 2, and PGE2 antagonized the enhancement. Dinoprostone 138-142 interferon gamma Homo sapiens 15-31 12445196-11 2002 These results suggest that A431-derived PGE2 may generate cAMP signal via EP4 in A431, which may activate protein kinase A, and may resultantly inhibit interferon-gamma-induced STAT1alpha activation and IP-10 synthesis. Dinoprostone 40-44 interferon gamma Homo sapiens 152-168 12417450-0 2002 Oral terbutaline differentially affects cytokine (IL-10, IL-12, TNF, IFNg) release in multiple sclerosis patients and controls. Terbutaline 5-16 interferon gamma Homo sapiens 69-73 12420101-3 2002 The profile encompasses three criteria, a) reduced proliferative response to GA (as observed with a standard primary proliferation assay); b) strong in vitro activation of interferon-gamma-producing T cells at high concentrations of GA (as detected by interferon-gamma ELISPOT); and c) activation of interleukin-4-producing T cells over a wider range of concentrations of GA (as detected by interleukin-4 ELISPOT). Gallium 233-235 interferon gamma Homo sapiens 172-188 12420101-3 2002 The profile encompasses three criteria, a) reduced proliferative response to GA (as observed with a standard primary proliferation assay); b) strong in vitro activation of interferon-gamma-producing T cells at high concentrations of GA (as detected by interferon-gamma ELISPOT); and c) activation of interleukin-4-producing T cells over a wider range of concentrations of GA (as detected by interleukin-4 ELISPOT). Gallium 233-235 interferon gamma Homo sapiens 252-268 12420101-3 2002 The profile encompasses three criteria, a) reduced proliferative response to GA (as observed with a standard primary proliferation assay); b) strong in vitro activation of interferon-gamma-producing T cells at high concentrations of GA (as detected by interferon-gamma ELISPOT); and c) activation of interleukin-4-producing T cells over a wider range of concentrations of GA (as detected by interleukin-4 ELISPOT). Gallium 233-235 interferon gamma Homo sapiens 172-188 12420101-3 2002 The profile encompasses three criteria, a) reduced proliferative response to GA (as observed with a standard primary proliferation assay); b) strong in vitro activation of interferon-gamma-producing T cells at high concentrations of GA (as detected by interferon-gamma ELISPOT); and c) activation of interleukin-4-producing T cells over a wider range of concentrations of GA (as detected by interleukin-4 ELISPOT). Gallium 233-235 interferon gamma Homo sapiens 252-268 12398992-2 2002 beta Androstenetriol increases the levels of the TH(1) cytokines, IL-2, IL-3, IFN gamma and counteracts hydrocortisone mediated immune suppression. beta androstenetriol 0-20 interferon gamma Homo sapiens 78-87 12482340-6 2002 (3) IFN-gamma mRNA was detected in unstimulated BMMNC in 13 of 16 SAA patients, 6 of 11 CAA patients and one of 6 paroxysmal nocturnal hemoglobinuria (PNH) patients. caa 88-91 interferon gamma Homo sapiens 4-13 12215380-5 2002 We treated cells with IFN-gamma to enhance the expression of FcgammaRI and to obtain enough production of superoxide. Superoxides 106-116 interferon gamma Homo sapiens 22-31 12372337-2 2002 We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer. tba 37-40 interferon gamma Homo sapiens 172-188 12372337-2 2002 We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer. tba 37-40 interferon gamma Homo sapiens 190-199 12372337-2 2002 We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer. tba 37-40 interferon gamma Homo sapiens 231-240 12372337-2 2002 We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer. Tetradecanoylphorbol Acetate 98-129 interferon gamma Homo sapiens 172-188 12372337-2 2002 We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer. Tetradecanoylphorbol Acetate 98-129 interferon gamma Homo sapiens 190-199 12372337-2 2002 We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer. Tetradecanoylphorbol Acetate 98-129 interferon gamma Homo sapiens 231-240 12372337-2 2002 We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer. Tetradecanoylphorbol Acetate 131-134 interferon gamma Homo sapiens 172-188 12372337-2 2002 We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer. Tetradecanoylphorbol Acetate 131-134 interferon gamma Homo sapiens 190-199 12372337-2 2002 We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer. Tetradecanoylphorbol Acetate 131-134 interferon gamma Homo sapiens 231-240 26984461-8 2002 RESULTS: A significant decrease in production of IFN-gamma was observed in cells stimulated with mitogens and co-incubated with imipramine or fluoxetine and TRH. Imipramine 128-138 interferon gamma Homo sapiens 49-58 26984461-8 2002 RESULTS: A significant decrease in production of IFN-gamma was observed in cells stimulated with mitogens and co-incubated with imipramine or fluoxetine and TRH. Fluoxetine 142-152 interferon gamma Homo sapiens 49-58 26984461-9 2002 Under the same conditions, TRH alone did not change the production of these cytokines, whereas imipramine alone significantly decreases IFN-gamma production, and fluoxetine alone significantly decreases IFN-gamma and TNF-alpha production. Imipramine 95-105 interferon gamma Homo sapiens 136-145 26984461-9 2002 Under the same conditions, TRH alone did not change the production of these cytokines, whereas imipramine alone significantly decreases IFN-gamma production, and fluoxetine alone significantly decreases IFN-gamma and TNF-alpha production. Fluoxetine 162-172 interferon gamma Homo sapiens 203-212 12223352-4 2002 IFN-gamma increased tyrosine phosphorylation in T84 cells at 24 h, including the EGFr. Tyrosine 20-28 interferon gamma Homo sapiens 0-9 12223352-6 2002 However, whereas IFN-gamma significantly inhibited carbachol-induced Cl(-) secretion, neither neutralizing antibodies to TGF-alpha nor an EGFr inhibitor (1 microM tyrphostin AG 1478) were able to reverse this inhibitory effect. Carbachol 51-60 interferon gamma Homo sapiens 17-26 12368213-3 2002 In this study, we investigated whether the NO donors, S-nitrosoglutathione (GS-NO) and NOR-1, could regulate chemokine production by human keratinocytes activated with interferon-gamma and tumor necrosis factor-alpha. S-Nitrosoglutathione 54-74 interferon gamma Homo sapiens 168-216 12368213-3 2002 In this study, we investigated whether the NO donors, S-nitrosoglutathione (GS-NO) and NOR-1, could regulate chemokine production by human keratinocytes activated with interferon-gamma and tumor necrosis factor-alpha. gs-no 76-81 interferon gamma Homo sapiens 168-216 12368221-6 2002 Treatment of CD95L-transduced cells with IFN-gamma causes apoptosis within 24 to 36 hours that can be blocked by antagonistic anti-CD95 antibody or by the caspase-inhibitory peptide zVAD-FMK. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 182-190 interferon gamma Homo sapiens 41-50 12202921-5 2002 In 1/3 to 2/3 of the subjects tested, sodium nitrate or nitrite decreased production of Th1 cytokines (interleukin-2, interferon-gamma, and tumor necrosis factor-beta). sodium nitrate 38-52 interferon gamma Homo sapiens 118-166 12202921-5 2002 In 1/3 to 2/3 of the subjects tested, sodium nitrate or nitrite decreased production of Th1 cytokines (interleukin-2, interferon-gamma, and tumor necrosis factor-beta). Nitrites 56-63 interferon gamma Homo sapiens 118-166 12325070-4 2002 As compared with pretreatment baseline, relapsing remitting patients treated with oral estriol (8 mg/day) demonstrated significant decreases in delayed type hypersensitivity responses to tetanus, interferon-gamma levels in peripheral blood mononuclear cells, and gadolinium enhancing lesion numbers and volumes on monthly cerebral magnetic resonance images. Estriol 87-94 interferon gamma Homo sapiens 196-212 12401473-1 2002 The cytokine interferon-gamma stimulates human monocytes/macrophages to release large amounts of neopterin. Neopterin 97-106 interferon gamma Homo sapiens 13-29 12401473-3 2002 In various cells interferon-gamma induces indoleamine 2,3-dioxygenase (IDO) which degrades tryptophan via the kynurenine pathway. Tryptophan 91-101 interferon gamma Homo sapiens 17-33 12401473-3 2002 In various cells interferon-gamma induces indoleamine 2,3-dioxygenase (IDO) which degrades tryptophan via the kynurenine pathway. Kynurenine 110-120 interferon gamma Homo sapiens 17-33 12296857-8 2002 The synthesis of TNF-alpha and IFN-gamma and the up-regulation of OX40 on T cells after secondary allogeneic stimulation were almost entirely blocked by 10 nm pimecrolimus. pimecrolimus 159-171 interferon gamma Homo sapiens 31-40 12517728-6 2002 LPMC from involved ileal, Crohn"s disease produced, in both non-stimulated and stimulated conditions, more IFN-gamma and IL-12p70 than LPMC from non-involved tissue or from control patients. lpmc 0-4 interferon gamma Homo sapiens 107-116 12517728-9 2002 LP-T cell-dependent activation of monocytes was then studied by co-culture of anti-CD3/CD80-stimulated LPMC with fresh monocytes, which resulted in high IL-12, IFN-gamma, TNF and IL-10 production. lpmc 103-107 interferon gamma Homo sapiens 160-169 12383199-2 2002 While RA (10(-8) m) alone did not alter STAT-1 activation or expression in THP-1 cells, RA enhanced or prolonged STAT-1 activation (tyrosine 701 phosphorylation) and gene expression (mRNA and protein) induced by either IFN-beta or IFN-gamma. Tretinoin 88-90 interferon gamma Homo sapiens 231-240 12352275-4 2002 After 8 weeks of double-blind treatment, there was no significant interaction between treatment status and length of treatment for positive, negative, or general symptoms according to the Positive and Negative Syndrome Scale, despite a hydroxychloroquine-associated decrease in serum interferon-gamma levels. Hydroxychloroquine 236-254 interferon gamma Homo sapiens 284-300 12232043-3 2002 Using p38alpha mitogen-activated protein kinase (MAPK)-deficient cells, we show that the stress-induced phosphorylation of Ser-727 requires p38alpha MAPK activity, whereas IFN-gamma-stimulated Ser-727 phosphorylation occurs independently of the p38alpha pathway. Serine 123-126 interferon gamma Homo sapiens 172-181 12232043-3 2002 Using p38alpha mitogen-activated protein kinase (MAPK)-deficient cells, we show that the stress-induced phosphorylation of Ser-727 requires p38alpha MAPK activity, whereas IFN-gamma-stimulated Ser-727 phosphorylation occurs independently of the p38alpha pathway. Serine 193-196 interferon gamma Homo sapiens 172-181 12232043-7 2002 Taken together, these results demonstrate an interaction between IFN-gamma signaling and the p38 pathway that leads to increased transcriptional activation by STAT1 independently of phosphorylation at Ser-727. Serine 201-204 interferon gamma Homo sapiens 65-74 12674935-10 2002 The effect of the two recombinant cytokines (IL-1 beta, IFN-gamma) on the character of free radical production and intracellular killing of Staphylococci by neutrophils isolated from the blood of patients and healthy donors has been studied. Free Radicals 87-99 interferon gamma Homo sapiens 56-65 12392968-9 2002 Positive identification of DNCB, HCA, and OXA as contact allergens on the basis of IFN-gamma production was observed only at very high stimulation indices (SI >or= 35) for DNCB and OXA and at low SIs (SI <or= 7) for HCA. Dinitrochlorobenzene 27-31 interferon gamma Homo sapiens 83-92 12670123-0 2002 Exposure to increased pressure or hyperbaric oxygen suppresses interferon-gamma secretion in whole blood cultures of healthy humans. Oxygen 45-51 interferon gamma Homo sapiens 63-79 12364868-0 2002 Effect of histamine on intercellular adhesion molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18. Histamine 10-19 interferon gamma Homo sapiens 86-102 12421573-1 2002 BACKGROUND: Serotonin (5-HT) has negative immunoregulatory effects by reducing the interferon-gamma (IFNgamma)/interleukin-10 (IL-10) production ratio by stimulated immune cells. Serotonin 12-21 interferon gamma Homo sapiens 83-99 12421573-1 2002 BACKGROUND: Serotonin (5-HT) has negative immunoregulatory effects by reducing the interferon-gamma (IFNgamma)/interleukin-10 (IL-10) production ratio by stimulated immune cells. Serotonin 12-21 interferon gamma Homo sapiens 101-109 12234989-6 2002 The effect of saquinavir on LPS/IFN-gamma-induced activation of NF-kappaB was assessed by gel-shift assays and by Western analysis of corresponding IkappaBalpha-levels. Saquinavir 14-24 interferon gamma Homo sapiens 32-41 12234989-9 2002 Saquinavir treatment prevented LPS/IFN-gamma-induced activation of NF-kappaB in RAW cells and stabilized expression of IkappaBalpha. Saquinavir 0-10 interferon gamma Homo sapiens 35-44 12351936-11 2002 Induction of nitrite production by a cytomix [IFNgamma (100 ng/ml) + TNFalpha (30 ng/ml) + IL-1beta (5 ng/ml)] was differentially enhanced by exposure to supplemental factors including LPS, L-arginine, and BH4. Nitrites 13-20 interferon gamma Homo sapiens 46-54 12351936-11 2002 Induction of nitrite production by a cytomix [IFNgamma (100 ng/ml) + TNFalpha (30 ng/ml) + IL-1beta (5 ng/ml)] was differentially enhanced by exposure to supplemental factors including LPS, L-arginine, and BH4. Arginine 190-200 interferon gamma Homo sapiens 46-54 12351936-11 2002 Induction of nitrite production by a cytomix [IFNgamma (100 ng/ml) + TNFalpha (30 ng/ml) + IL-1beta (5 ng/ml)] was differentially enhanced by exposure to supplemental factors including LPS, L-arginine, and BH4. sapropterin 206-209 interferon gamma Homo sapiens 46-54 12234479-0 2002 A modified kynurenine bioassay for quantitative determination of human interferon-gamma. Kynurenine 11-21 interferon gamma Homo sapiens 71-87 12529971-0 2002 IFN gamma-induced up-regulation of PD-ECGF/TP enhances the cytotoxicity of 5-fluorouracil and 5"-deoxy-5-fluorouridine in bladder cancer cells. Fluorouracil 75-89 interferon gamma Homo sapiens 0-9 12529971-0 2002 IFN gamma-induced up-regulation of PD-ECGF/TP enhances the cytotoxicity of 5-fluorouracil and 5"-deoxy-5-fluorouridine in bladder cancer cells. doxifluridine 94-118 interferon gamma Homo sapiens 0-9 12207582-9 2002 Using the ELISpot assay, we found that PBMC from nickel-allergic individuals responded to Ni2+ with significantly greater production of interleukin (IL)-4, IL-5, IL-13 and interferon-gamma, but not IL-12, compared with the healthy controls. Nickel 49-55 interferon gamma Homo sapiens 172-188 12207582-9 2002 Using the ELISpot assay, we found that PBMC from nickel-allergic individuals responded to Ni2+ with significantly greater production of interleukin (IL)-4, IL-5, IL-13 and interferon-gamma, but not IL-12, compared with the healthy controls. Nickel(2+) 90-94 interferon gamma Homo sapiens 172-188 12203391-2 2002 Mycophenolic acid (MPA), a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH), inhibited interferon-gamma (IFN-gamma) + lipopolysaccharide (LPS)-induced NO production dose-dependently in astrocytes, but not in macrophages. Mycophenolic Acid 0-17 interferon gamma Homo sapiens 105-121 12203391-2 2002 Mycophenolic acid (MPA), a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH), inhibited interferon-gamma (IFN-gamma) + lipopolysaccharide (LPS)-induced NO production dose-dependently in astrocytes, but not in macrophages. Mycophenolic Acid 0-17 interferon gamma Homo sapiens 123-132 12203391-2 2002 Mycophenolic acid (MPA), a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH), inhibited interferon-gamma (IFN-gamma) + lipopolysaccharide (LPS)-induced NO production dose-dependently in astrocytes, but not in macrophages. Mycophenolic Acid 19-22 interferon gamma Homo sapiens 105-121 12203391-2 2002 Mycophenolic acid (MPA), a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH), inhibited interferon-gamma (IFN-gamma) + lipopolysaccharide (LPS)-induced NO production dose-dependently in astrocytes, but not in macrophages. Mycophenolic Acid 19-22 interferon gamma Homo sapiens 123-132 12225374-5 2002 We found that tumour necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and to a lesser extent interleukin (IL)-10 production was inhibited by all PGE-subtypes in ConA-stimulated PBMC concomitant with unaffected IL-2 levels. Prostaglandins E 160-163 interferon gamma Homo sapiens 56-72 12225374-5 2002 We found that tumour necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and to a lesser extent interleukin (IL)-10 production was inhibited by all PGE-subtypes in ConA-stimulated PBMC concomitant with unaffected IL-2 levels. Prostaglandins E 160-163 interferon gamma Homo sapiens 74-83 12202538-9 2002 IFNgamma stimulation also increased permeability of CEC monolayers, whereas subsequent TA treatment decreased permeability of CEC monolayers. cec 52-55 interferon gamma Homo sapiens 0-8 12355561-4 2002 Exposure to all three acid anhydrides stimulated vigorous expression of interleukin (IL)-5, IL-10 and IL-13 but relatively low levels of the type 1 cytokines interferon-gamma (IFN-gamma) and IL-12. acid anhydrides 22-37 interferon gamma Homo sapiens 176-185 12405158-5 2002 In addition, some CD4+ TCC produced substantial amounts of IFN-gamma and MIP-1alpha/beta were perforin-positive, and showed cytotoxic activity. Triclocarban 23-26 interferon gamma Homo sapiens 59-68 12193739-4 2002 HMC-1-induced IL-8 release was significantly reduced by the tryptase inhibitors GW-45 and GW-58 (90 and 87%, respectively, at an optimal concentration) but not by anti-stem cell factor, anti-TNF-alpha, or anti-IFN-gamma neutralizing Abs or by the antihistamine drugs pyrilamine and cimetidine. gw-58 90-95 interferon gamma Homo sapiens 210-219 12223516-5 2002 IFN-gamma also enhanced the adhesion of human eosinophilic leukemia-1 cells to endothelial monolayers, and it was inhibited by the presence of lactose. Lactose 143-150 interferon gamma Homo sapiens 0-9 12210826-0 2002 Interferon-gamma acutely induces calcium influx in human microglia. Calcium 33-40 interferon gamma Homo sapiens 0-16 12210826-1 2002 The acute actions of the cytokine, interferon-gamma (IFN-gamma), on intracellular calcium [Ca(2+)](i) levels in human microglia were investigated. Calcium 82-89 interferon gamma Homo sapiens 35-51 12210826-1 2002 The acute actions of the cytokine, interferon-gamma (IFN-gamma), on intracellular calcium [Ca(2+)](i) levels in human microglia were investigated. Calcium 82-89 interferon gamma Homo sapiens 53-62 12210826-2 2002 In the presence of a calcium-containing physiological solution (Ca(2+)-PSS), IFN-gamma caused a progressive increase in [Ca(2+)](i) to a plateau level with a mean rate of increase of 0.81 +/- 0.17 nM/s and mean amplitude of 102 +/- 12 nM (n = 67 cells). Calcium 21-28 interferon gamma Homo sapiens 77-86 12210826-6 2002 The increase in [Ca(2+)](i) induced in Ca(2+)-PSS was reduced to near baseline levels when the external solution contained low Cl(-) in the maintained presence of IFN-gamma suggesting that cellular depolarization inhibited the cytokine mediated entry pathway. ca(2+)-pss 39-49 interferon gamma Homo sapiens 163-172 12210826-7 2002 The compound SKF96365, which blocks store operated influx of Ca(2+) in human microglia, was ineffective in altering the increase in [Ca(2+)](i), however, La(3+) completely inhibited the Ca(2+) response induced by IFN-gamma. lanthanum(3+) 154-160 interferon gamma Homo sapiens 213-222 12186889-6 2002 poly(C)] and encephalomyocarditis virus were greatly enhanced by IFN-gamma pretreatment (priming) of wild-type cells or of mutant cells lacking an IFN-alpha/beta response; these include the primary induction of dsRNA-inducible mRNAs, including IFN-beta mRNA, and, to a lesser extent, the dsRNA-mediated activation of the p38 mitogen-activated protein (MAP) kinase(s). Poly C 0-7 interferon gamma Homo sapiens 65-74 12411008-4 2002 RESULTS: (1) In supernatants of cultured PHA induced PBMC, the levels of IFN-gamma and TNF-alpha of study group were (639 +/- 156) ng/L and (1 021 +/- 231) ng/L, which were significantly higher than those of control group, (464 +/- 147) ng/L and (728 +/- 175) ng/L (P < 0.001); the IL-4 level of study group was (22 +/- 4) ng/L, which was lower than that of control group, (27 +/- 6) ng/L (P < 0.05); (2) In supernatants, the ratio of TNF-alpha/IL-4 of study group was 48 +/- 11, which was significantly higher than that of control group (30 +/- 8), the ratio of IFN-gamma/IL-4 of study group was 30 +/- 8, which was also higher than that of control group (19 +/- 6, P < 0.001); (3) There were significant positive correlations between total bile acid and concentrations of the TH(1) cytokines, the correlation coefficients(r) were 0.458 and 0.692, respectively (P < 0.01). Bile Acids and Salts 751-760 interferon gamma Homo sapiens 73-82 12127676-4 2002 methylprednisolone (MP) led to an increase of IL-4 mRNA and a significant decrease of IFN-gamma and TNF-alpha mRNA expression. Methylprednisolone 0-18 interferon gamma Homo sapiens 86-95 12127676-4 2002 methylprednisolone (MP) led to an increase of IL-4 mRNA and a significant decrease of IFN-gamma and TNF-alpha mRNA expression. Methylprednisolone 20-22 interferon gamma Homo sapiens 86-95 12227986-3 2002 Parameters related to iron metabolism, such as serum iron (SI), serum ferritin (SF), and soluble transferrin receptor (sTfR) were correlated to levels of interferon-gamma (IFN-gamma) and results compared to a group of 42 nonanemic patients with HIV. Iron 22-26 interferon gamma Homo sapiens 172-181 12227986-3 2002 Parameters related to iron metabolism, such as serum iron (SI), serum ferritin (SF), and soluble transferrin receptor (sTfR) were correlated to levels of interferon-gamma (IFN-gamma) and results compared to a group of 42 nonanemic patients with HIV. Iron 22-26 interferon gamma Homo sapiens 154-170 12165081-5 2002 In contrast, NAC up-regulated interferon-gamma (IFN-gamma) production. Acetylcysteine 13-16 interferon gamma Homo sapiens 30-46 12165081-5 2002 In contrast, NAC up-regulated interferon-gamma (IFN-gamma) production. Acetylcysteine 13-16 interferon gamma Homo sapiens 48-57 12171874-0 2002 Modulation of the Fas signaling pathway by IFN-gamma in therapy of colon cancer: phase I trial and correlative studies of IFN-gamma, 5-fluorouracil, and leucovorin. Fluorouracil 133-147 interferon gamma Homo sapiens 43-52 12171874-0 2002 Modulation of the Fas signaling pathway by IFN-gamma in therapy of colon cancer: phase I trial and correlative studies of IFN-gamma, 5-fluorouracil, and leucovorin. Leucovorin 153-163 interferon gamma Homo sapiens 43-52 12171874-1 2002 Potentiation of 5-fluorouracil/leucovorin (FUra/LV) cytotoxicity by IFN-gamma in colon carcinoma cells is dependent on FUra-induced DNA damage, the Fas death receptor, and independent of p53 and RNA-mediated FUra toxicity, which occurs in normal gastrointestinal tissues. Fluorouracil 16-30 interferon gamma Homo sapiens 68-77 12171874-1 2002 Potentiation of 5-fluorouracil/leucovorin (FUra/LV) cytotoxicity by IFN-gamma in colon carcinoma cells is dependent on FUra-induced DNA damage, the Fas death receptor, and independent of p53 and RNA-mediated FUra toxicity, which occurs in normal gastrointestinal tissues. Leucovorin 31-41 interferon gamma Homo sapiens 68-77 12171874-1 2002 Potentiation of 5-fluorouracil/leucovorin (FUra/LV) cytotoxicity by IFN-gamma in colon carcinoma cells is dependent on FUra-induced DNA damage, the Fas death receptor, and independent of p53 and RNA-mediated FUra toxicity, which occurs in normal gastrointestinal tissues. fura 43-47 interferon gamma Homo sapiens 68-77 12171874-1 2002 Potentiation of 5-fluorouracil/leucovorin (FUra/LV) cytotoxicity by IFN-gamma in colon carcinoma cells is dependent on FUra-induced DNA damage, the Fas death receptor, and independent of p53 and RNA-mediated FUra toxicity, which occurs in normal gastrointestinal tissues. Leucovorin 48-50 interferon gamma Homo sapiens 68-77 12171874-1 2002 Potentiation of 5-fluorouracil/leucovorin (FUra/LV) cytotoxicity by IFN-gamma in colon carcinoma cells is dependent on FUra-induced DNA damage, the Fas death receptor, and independent of p53 and RNA-mediated FUra toxicity, which occurs in normal gastrointestinal tissues. fura 119-123 interferon gamma Homo sapiens 68-77 12171874-2 2002 This provides a rationale for enhancing the selective action of FUra/LV by IFN-gamma in the treatment of colorectal carcinoma. fura 64-68 interferon gamma Homo sapiens 75-84 12171874-2 2002 This provides a rationale for enhancing the selective action of FUra/LV by IFN-gamma in the treatment of colorectal carcinoma. Leucovorin 69-71 interferon gamma Homo sapiens 75-84 12171874-9 2002 Serial plasma samples revealed peak FUra concentrations of >100 micro M; at 100 micro g/m2 IFN-gamma plasma concentrations >5 units/ml persisted for 6.5 h and >1 unit/ml for 28.5 h. The pharmacokinetic parameters of IFN-gamma correlated with a 2-3-fold up-regulation of Fas expression at 24 h in CD15+ cells in peripheral blood samples. fura 36-40 interferon gamma Homo sapiens 94-103 12171874-10 2002 Furthermore, clinically relevant IFN-gamma concentrations up-regulated Fas expression and sensitized HT29 colon carcinoma cells in vitro to FUra/LV cytotoxicity. fura 140-144 interferon gamma Homo sapiens 33-42 12171874-10 2002 Furthermore, clinically relevant IFN-gamma concentrations up-regulated Fas expression and sensitized HT29 colon carcinoma cells in vitro to FUra/LV cytotoxicity. Leucovorin 145-147 interferon gamma Homo sapiens 33-42 12190666-11 2002 Cyclooxygenase-2 inhibitor NS-398 suppressed PGE2 responses to MF, CA and TR, and partially suppressed IL-4 and MDC responses to MF, CA and TR, while enhanced IFN-gamma and IP-10 responses to CA in AD patients, and these effects of NS-398 were reversed by cyclic AMP analogue. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 27-33 interferon gamma Homo sapiens 159-168 12088678-5 2002 IFN-gamma-mediated effector mechanisms may involve effects on the metabolism of tryptophan or iron, on the inducible NO synthase (iNOS), on the secretion of chemokines and adhesion molecules or on the regulation of T-cell activities. Tryptophan 80-90 interferon gamma Homo sapiens 0-9 12088678-5 2002 IFN-gamma-mediated effector mechanisms may involve effects on the metabolism of tryptophan or iron, on the inducible NO synthase (iNOS), on the secretion of chemokines and adhesion molecules or on the regulation of T-cell activities. Iron 94-98 interferon gamma Homo sapiens 0-9 12115528-5 2002 IFN-gamma upregulates many apoptosis-related molecules, including Fas, caspase-3, caspase-4, caspase-7, caspase-8 and Bak, in both cell lines. ammonium ferrous sulfate 66-69 interferon gamma Homo sapiens 0-9 12115528-5 2002 IFN-gamma upregulates many apoptosis-related molecules, including Fas, caspase-3, caspase-4, caspase-7, caspase-8 and Bak, in both cell lines. bakuchiol 118-121 interferon gamma Homo sapiens 0-9 12133875-7 2002 Intracellular expression of IFN-gamma, IL-2, and IL-4 was detected in CD4(+) and CD8(+) T cells after stimulation with phorbol 12-myristate 13-acetate and ionomycin. Tetradecanoylphorbol Acetate 119-150 interferon gamma Homo sapiens 28-37 12133875-7 2002 Intracellular expression of IFN-gamma, IL-2, and IL-4 was detected in CD4(+) and CD8(+) T cells after stimulation with phorbol 12-myristate 13-acetate and ionomycin. Ionomycin 155-164 interferon gamma Homo sapiens 28-37 12354520-2 2002 Both IFN-gamma and TNF-alpha mRNA were detected in the lung as early as 1 day post-inoculation (dpi) and up to 10 dpi. 3-aminodiphenyleneiodium 96-99 interferon gamma Homo sapiens 5-14 12354520-2 2002 Both IFN-gamma and TNF-alpha mRNA were detected in the lung as early as 1 day post-inoculation (dpi) and up to 10 dpi. 3-aminodiphenyleneiodium 114-117 interferon gamma Homo sapiens 5-14 12908619-0 2003 Taurine chloramine inhibits production of inflammatory mediators and iNOS gene expression in alveolar macrophages; a tale of two pathways: part II, IFN-gamma signaling through JAK/Stat. N-chlorotaurine 0-18 interferon gamma Homo sapiens 148-157 12134231-2 2002 Both native PT (nPT) and genetically detoxified PT (dPT) efficiently promoted expression on DCs of CD80, CD86, human leukocyte antigen-DR, and CD83 markers, alloreactive antigen presentation, and cytokine production, primarily interferon (IFN)-gamma. dpt 52-55 interferon gamma Homo sapiens 227-249 12152923-12 2002 The data suggests that sera from healthy SCD patients and in vitro added penicillin may have a combined suppressive effect on normal lymphocyte in vitro production of IFN-gamma and TNF-alpha. Penicillins 73-83 interferon gamma Homo sapiens 167-176 12171292-0 2002 Priming of human oral epithelial cells by interferon-gamma to secrete cytokines in response to lipopolysaccharides, lipoteichoic acids and peptidoglycans. lipoteichoic acid 116-134 interferon gamma Homo sapiens 42-58 12185450-3 2002 IFN-gamma pretreatment resulted in a dramatic inhibition of transfection efficiency mediated by a cationic liposome (DOTAP). 1,2-dioleoyloxy-3-(trimethylammonium)propane 117-122 interferon gamma Homo sapiens 0-9 12185450-5 2002 In primary nasal and bronchial cells cytofluorimetric analysis demonstrated that IFN-gamma reduces binding of FITC-labeled complexes. Fluorescein-5-isothiocyanate 110-114 interferon gamma Homo sapiens 81-90 12683414-6 2003 PMDD immunisation induced a frequency of 168YPHFMPTNL176-specific interferon-gamma (IFN-gamma)-secreting splenocytes, which was equivalent to that after K181 infection and significantly higher than tsm immunisation. pmdd 0-4 interferon gamma Homo sapiens 84-93 12165750-11 2002 Tissue culture supernatant from women with RSA also produced higher concentration of TNF-alpha, IFN-gamma, TNF-beta and IL2, than control group. rabbit sperm membrane autoantigen 43-46 interferon gamma Homo sapiens 96-105 12176411-0 2002 Inhibition of IL-12 signaling Stat4/IFN-gamma pathway by rapamycin is associated with impaired dendritic [correction of dendritc] cell function. Sirolimus 57-66 interferon gamma Homo sapiens 36-45 12191570-1 2002 When cells were incubated in the presence of both interferon-gamma (IFN-gamma) and all-trans retinoic acid (ATRA), the concentration of IFN-gamma required to induce apoptosis of B-cell lymphoma cells was much lower than that required for myeloid or erythroid cell lines. Tretinoin 93-106 interferon gamma Homo sapiens 136-145 12191570-1 2002 When cells were incubated in the presence of both interferon-gamma (IFN-gamma) and all-trans retinoic acid (ATRA), the concentration of IFN-gamma required to induce apoptosis of B-cell lymphoma cells was much lower than that required for myeloid or erythroid cell lines. Tretinoin 108-112 interferon gamma Homo sapiens 136-145 12006557-2 2002 We demonstrate that IFN-gamma induces the expression of HLA-DRA in vascular endothelial cells via mechanisms involving reactive oxygen species. Reactive Oxygen Species 119-142 interferon gamma Homo sapiens 20-29 12136075-1 2002 In this study, the authors show that MG as an autoantibody-mediated disorder of neuromuscular transmission is associated with elevated serum levels of the interferon-gamma-inducing cytokine interleukin (IL)-18. Magnesium 37-39 interferon gamma Homo sapiens 155-171 12006557-8 2002 These results indicate that NO and antioxidants may attenuate vascular inflammation by antagonizing the effects of intracellular reactive oxygen species generation by IFN-gamma, which is necessary for MHC-II gene transcription. Reactive Oxygen Species 129-152 interferon gamma Homo sapiens 167-176 12167345-3 2002 After stimulation with phorbol 12-myristate 13-acetate and ionomycin, an increase in the percentage of IFN-gamma and IL-4 producing CD8(+) T cells was observed during aging. Tetradecanoylphorbol Acetate 23-54 interferon gamma Homo sapiens 103-112 12167345-3 2002 After stimulation with phorbol 12-myristate 13-acetate and ionomycin, an increase in the percentage of IFN-gamma and IL-4 producing CD8(+) T cells was observed during aging. Ionomycin 59-68 interferon gamma Homo sapiens 103-112 12133935-8 2002 In addition, cAMP-primed CD45RA cells produce considerable amounts of the Th2 cytokines, IL-4, IL-10, and IL-13, whereas the production of IFN-gamma and TNF-alpha was nearly undetectable. Cyclic AMP 13-17 interferon gamma Homo sapiens 139-148 12105943-0 2002 Effects of anthocyanins and other phenolic compounds on the production of tumor necrosis factor alpha in LPS/IFN-gamma-activated RAW 264.7 macrophages. Anthocyanins 11-23 interferon gamma Homo sapiens 109-118 11980899-8 2002 Cells transfected with 2-5 AS antisense oligonucleotides inhibit the antiviral effect of IFN-gamma. Oligonucleotides 40-56 interferon gamma Homo sapiens 89-98 12100149-7 2002 The proliferative activity of the lymphocytes, IL-2 and IFN-gamma production remained significantly lower in CR compared with controls. Chromium 109-111 interferon gamma Homo sapiens 56-65 12006557-3 2002 IFN-gamma-induced HLA-DRA expression was inhibited by nitric oxide (NO) and antioxidants such as superoxide dismutase, catalase, pyrrolidine dithiocarbamate, and N-acetylcysteine. Nitric Oxide 54-66 interferon gamma Homo sapiens 0-9 12006557-3 2002 IFN-gamma-induced HLA-DRA expression was inhibited by nitric oxide (NO) and antioxidants such as superoxide dismutase, catalase, pyrrolidine dithiocarbamate, and N-acetylcysteine. pyrrolidine dithiocarbamic acid 129-156 interferon gamma Homo sapiens 0-9 12006557-3 2002 IFN-gamma-induced HLA-DRA expression was inhibited by nitric oxide (NO) and antioxidants such as superoxide dismutase, catalase, pyrrolidine dithiocarbamate, and N-acetylcysteine. Acetylcysteine 162-178 interferon gamma Homo sapiens 0-9 12006557-6 2002 However, H(2)O(2) and N(omega)-monomethyl-l-arginine could induce HLA-DRA expression suggesting that H(2)O(2) is a necessary but not a sufficient mediator of IFN-gamma-induced HLA-DRA expression. hippuric acid 11-14 interferon gamma Homo sapiens 158-167 12070711-4 2002 Cycloheximide, a protein synthesis inhibitor, also induced uPAR mRNA accumulation either alone or in combination with IFN-alpha or IFN-gamma, suggesting that the effect on uPAR mRNA levels activated by IFN-alpha or IFN-gamma does not require de novo protein synthesis. Cycloheximide 0-13 interferon gamma Homo sapiens 131-140 12085250-12 2002 More specifically, docetaxel demonstrated a more pronounced effect on enhancing MLR, NK, LAK activity and IFN-gamma, IL-2, IL-6, and GM-CSF levels, as well as caused more potent reduction in IL-1 and TNF-alpha levels when compared to paclitaxel. Docetaxel 19-28 interferon gamma Homo sapiens 106-115 12085250-13 2002 The present study indicates that patients responded to treatment of advanced breast cancer with single-agent paclitaxel or docetaxel leads to an increase in serum IFN-gamma, IL-2, IL-6, GM-CSF cytokine levels and enhancement of PBMC NK and LAK cell activity, while they both lead to a decrease of acute phase serum cytokine levels of IL-1 and TNF-alpha. Paclitaxel 109-119 interferon gamma Homo sapiens 163-172 12085250-13 2002 The present study indicates that patients responded to treatment of advanced breast cancer with single-agent paclitaxel or docetaxel leads to an increase in serum IFN-gamma, IL-2, IL-6, GM-CSF cytokine levels and enhancement of PBMC NK and LAK cell activity, while they both lead to a decrease of acute phase serum cytokine levels of IL-1 and TNF-alpha. Docetaxel 123-132 interferon gamma Homo sapiens 163-172 12072188-4 2002 Importantly, diltiazem-induced DCs have an impaired responsiveness to lipopolysaccharide and CD40 ligand because they produce decreased levels of IL-12 and reveal a reduced ability to stimulate alloreactive T-cell responses as well as in inducing interferon-gamma producing Th1 cells. Diltiazem 13-22 interferon gamma Homo sapiens 247-263 12100719-6 2002 Indeed, EtxB was shown to inhibit IL-12 secretion in monocytes stimulated with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) by an IL-10-independent mechanism. etxb 8-12 interferon gamma Homo sapiens 79-95 12100719-6 2002 Indeed, EtxB was shown to inhibit IL-12 secretion in monocytes stimulated with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) by an IL-10-independent mechanism. etxb 8-12 interferon gamma Homo sapiens 97-106 12100719-7 2002 When EtxB-treated monocytes were used as antigen presenting cells in an allogeneic mixed lymphocyte reaction (MLR), IL-10 and IFN-gamma production were increased in comparison to levels seen in cultures stimulated with untreated monocytes; proliferation was unaltered. etxb 5-9 interferon gamma Homo sapiens 126-135 12349951-2 2002 To assess if thalidomide could concomitantly enhance the synthesis of IFN-gamma and incorporation of [H3]-thymidine, peripheral blood mononuclear cells (PBMC) were incubated in the presence or absence of thalidomide and staphylococcal enterotoxin A (SEA), anti-CD3, Con-A or PHA. Thalidomide 13-24 interferon gamma Homo sapiens 70-79 12349951-6 2002 Thalidomide enhanced IFN-gamma synthesis in the Con-A and anti-CD3-stimulated PBMC. Thalidomide 0-11 interferon gamma Homo sapiens 21-30 12070711-4 2002 Cycloheximide, a protein synthesis inhibitor, also induced uPAR mRNA accumulation either alone or in combination with IFN-alpha or IFN-gamma, suggesting that the effect on uPAR mRNA levels activated by IFN-alpha or IFN-gamma does not require de novo protein synthesis. Cycloheximide 0-13 interferon gamma Homo sapiens 215-224 12060847-7 2002 Activation of RhoA activity with lysophosphatidic acid (LPA) increased 2-fold the adhesion of monocytic cells to Fn in a alpha5beta1-mediated fashion, and IFN-gamma treatment reversed the enhancing effect of LPA. lysophosphatidic acid 208-211 interferon gamma Homo sapiens 155-164 12070711-5 2002 Both sodium butyrate and amiloride inhibited the uPAR mRNA levels induced by IFN-alpha or IFN-gamma. Butyric Acid 5-20 interferon gamma Homo sapiens 90-99 12070711-5 2002 Both sodium butyrate and amiloride inhibited the uPAR mRNA levels induced by IFN-alpha or IFN-gamma. Amiloride 25-34 interferon gamma Homo sapiens 90-99 12044887-0 2002 Flavonoids differentially regulate IFN gamma-induced ICAM-1 expression in human keratinocytes: molecular mechanisms of action. Flavonoids 0-10 interferon gamma Homo sapiens 35-44 12077223-7 2002 ATPgammaS and BzATP inhibited secretion of IL-2, IL-5, IL-10, and IFN-gamma; expression of CD25; and proliferation after activation of CD4(+) T cells by immobilized anti-CD3 and soluble anti-CD28 Abs, without increasing cell death. adenosine 5'-O-(3-thiotriphosphate) 0-9 interferon gamma Homo sapiens 66-75 12077223-7 2002 ATPgammaS and BzATP inhibited secretion of IL-2, IL-5, IL-10, and IFN-gamma; expression of CD25; and proliferation after activation of CD4(+) T cells by immobilized anti-CD3 and soluble anti-CD28 Abs, without increasing cell death. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 14-19 interferon gamma Homo sapiens 66-75 12101269-6 2002 Inhibition of phagocytosis by PD98059 was observed after 24 h of IFN-gamma treatment, whereas wortmannin could inhibit phagocytosis only after 48 h of IFN-gamma treatment. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 interferon gamma Homo sapiens 65-74 12101269-6 2002 Inhibition of phagocytosis by PD98059 was observed after 24 h of IFN-gamma treatment, whereas wortmannin could inhibit phagocytosis only after 48 h of IFN-gamma treatment. Wortmannin 94-104 interferon gamma Homo sapiens 151-160 12101280-5 2002 In contrast, IL-12- and IL-18-induced interferon-gamma (INF-gamma) secretion from T cells was inhibited by SB203580, but not by PD098059. SB 203580 107-115 interferon gamma Homo sapiens 38-54 12101280-5 2002 In contrast, IL-12- and IL-18-induced interferon-gamma (INF-gamma) secretion from T cells was inhibited by SB203580, but not by PD098059. SB 203580 107-115 interferon gamma Homo sapiens 56-65 12113880-0 2002 Interferon gamma antagonizes interleukin-1beta-induced cyclooxygenase-2 expression and prostaglandin E(2) production in human myometrial cells. Dinoprostone 87-105 interferon gamma Homo sapiens 0-16 12136890-8 2002 IL-15 production stimulated by interferon-gamma (IFN-gamma), IL-1beta, or lipopolysaccharide were also strongly inhibited by PGE2. Dinoprostone 125-129 interferon gamma Homo sapiens 31-47 12136890-8 2002 IL-15 production stimulated by interferon-gamma (IFN-gamma), IL-1beta, or lipopolysaccharide were also strongly inhibited by PGE2. Dinoprostone 125-129 interferon gamma Homo sapiens 49-58 12708088-8 2002 The latter can be referred to the correction of an inhibitory effect of iron towards IFN-gamma induced immune effector pathways in macrophages. Iron 72-76 interferon gamma Homo sapiens 85-94 12044887-3 2002 Among the flavonoids tested, taxifolin was the most potent in inhibiting interferon gamma (IFN gamma)-induced ICAM-1 protein as well as mRNA expression in human keratinocytes. taxifolin 29-38 interferon gamma Homo sapiens 73-100 12044887-6 2002 Finally, taxifolin pre-treatment also potently inhibited IFN gamma-induced ICAM-1 expression in a reconstructed human skin equivalent suggesting therapeutic potential of taxifolin in skin pathological conditions related to increased cell adhesion and inflammation. taxifolin 9-18 interferon gamma Homo sapiens 57-66 12044887-6 2002 Finally, taxifolin pre-treatment also potently inhibited IFN gamma-induced ICAM-1 expression in a reconstructed human skin equivalent suggesting therapeutic potential of taxifolin in skin pathological conditions related to increased cell adhesion and inflammation. taxifolin 170-179 interferon gamma Homo sapiens 57-66 12087451-1 2002 Cancer-related indoleamine (2,3)-dioxygenase up-regulation by interferon-gamma might influence quality of life by depleting serum tryptophan. Tryptophan 130-140 interferon gamma Homo sapiens 62-78 12087451-9 2002 The results supported a role for interferon-gamma-mediated serum tryptophan decrease in cancer-induced quality of life deterioration. Tryptophan 65-75 interferon gamma Homo sapiens 33-49 12182454-5 2002 Three healthy donors received TT booster-immunizations and showed significant increases in the number of TT-specific IFN-gamma secreting T cells which reached peak levels by 4 weeks after vaccination. tt booster 30-40 interferon gamma Homo sapiens 117-126 12113880-1 2002 OBJECTIVE: To evaluate the effect of interferon gamma (IFNgamma) on interleukin-1beta (IL-1) and tumor necrosis factor-alpha (TNFalpha)-promoted prostaglandin E(2) (PGE(2)) production and to investigate the interaction of IFNgamma and IL-1 on cyclooxygenase-2 (COX-2) expression, as well as nuclear factor-kappaB (NF-kappaB) activation in human myometrial cells. Prostaglandins E 145-160 interferon gamma Homo sapiens 37-64 12113880-1 2002 OBJECTIVE: To evaluate the effect of interferon gamma (IFNgamma) on interleukin-1beta (IL-1) and tumor necrosis factor-alpha (TNFalpha)-promoted prostaglandin E(2) (PGE(2)) production and to investigate the interaction of IFNgamma and IL-1 on cyclooxygenase-2 (COX-2) expression, as well as nuclear factor-kappaB (NF-kappaB) activation in human myometrial cells. Prostaglandins E 145-160 interferon gamma Homo sapiens 55-63 12113880-1 2002 OBJECTIVE: To evaluate the effect of interferon gamma (IFNgamma) on interleukin-1beta (IL-1) and tumor necrosis factor-alpha (TNFalpha)-promoted prostaglandin E(2) (PGE(2)) production and to investigate the interaction of IFNgamma and IL-1 on cyclooxygenase-2 (COX-2) expression, as well as nuclear factor-kappaB (NF-kappaB) activation in human myometrial cells. Prostaglandins E 165-168 interferon gamma Homo sapiens 37-64 12113880-1 2002 OBJECTIVE: To evaluate the effect of interferon gamma (IFNgamma) on interleukin-1beta (IL-1) and tumor necrosis factor-alpha (TNFalpha)-promoted prostaglandin E(2) (PGE(2)) production and to investigate the interaction of IFNgamma and IL-1 on cyclooxygenase-2 (COX-2) expression, as well as nuclear factor-kappaB (NF-kappaB) activation in human myometrial cells. Prostaglandins E 165-168 interferon gamma Homo sapiens 55-63 12113880-6 2002 RESULTS: Cell cultures primed with IFNgamma produced significantly less (P <.05-.01) PGE(2) in response to cytokines than cells exposed to IL-1, TNF-alpha, or the combination of the two. Prostaglandins E 88-91 interferon gamma Homo sapiens 35-43 12113880-8 2002 CONCLUSION: Interferon gamma acts as a partial antagonist of IL-1 signaling in this cell model at a site upstream from the activation of the NF-kappaB pathway, causing a partial inhibition of COX-2 expression and PGE(2) production. Prostaglandins E 213-216 interferon gamma Homo sapiens 12-28 12185324-7 2002 Expressed cytokines in the D-glucosamine-treated cells were IL-2, IFN-gamma, and IL-12 p40 subunit. Glucosamine 27-40 interferon gamma Homo sapiens 66-75 12185324-9 2002 These results suggest chitosan as well as D-glucosamine could induce the expression of cytokines as Th1 subset such as IL-2, IFN-gamma. Glucosamine 42-55 interferon gamma Homo sapiens 125-134 12062936-9 2002 For the moderately responding sensitisers TMTD and ZDMC both IFN-gamma and IL-4 production was observed. Ziram 51-55 interferon gamma Homo sapiens 61-70 12062936-10 2002 For the weakly responding sensitisers DEA and MBT both IFN-gamma and IL-4 cytokine production was only observed after pretreatment of the animals with 10% SDS. Sodium Dodecyl Sulfate 155-158 interferon gamma Homo sapiens 55-64 12298152-7 2002 The participation of IFN-gamma in immune reactions of CNS also is carried out at the expense of amplification under its influence of superoxide production, NO and prostaglandine synthesis, expression in astrocytes and microglial cells of ICAM adgesive molecule. Superoxides 133-143 interferon gamma Homo sapiens 21-30 12298152-7 2002 The participation of IFN-gamma in immune reactions of CNS also is carried out at the expense of amplification under its influence of superoxide production, NO and prostaglandine synthesis, expression in astrocytes and microglial cells of ICAM adgesive molecule. Prostaglandins E 163-177 interferon gamma Homo sapiens 21-30 12044887-3 2002 Among the flavonoids tested, taxifolin was the most potent in inhibiting interferon gamma (IFN gamma)-induced ICAM-1 protein as well as mRNA expression in human keratinocytes. Flavonoids 10-20 interferon gamma Homo sapiens 73-100 12035045-11 2002 RESULTS: More than 90% (90% +/- 3.5%) of Fas-positive and 70% (71 +/- 2.3%) of Fas-negative cells underwent apoptosis after TMX treatment when pretreated with IFN-gamma. Tamoxifen 124-127 interferon gamma Homo sapiens 159-168 26984153-3 2002 The synthesis of BH4 is stimulated by interferon-gamma and hence there is a close relationship with the immune system HPA-axis. sapropterin 17-20 interferon gamma Homo sapiens 38-54 12035045-14 2002 CONCLUSION: TMX exposure to human cholangiocarcinoma after pretreatment with IFN-gamma allows for induction of apoptosis in vitro and significant inhibition tumor xenograft growth. Tamoxifen 12-15 interferon gamma Homo sapiens 77-86 12035045-0 2002 Tamoxifen (TMX)/Fas induced growth inhibition of human cholangiocarcinoma (HCC) by gamma interferon (IFN-gamma). Tamoxifen 0-9 interferon gamma Homo sapiens 83-110 12035045-0 2002 Tamoxifen (TMX)/Fas induced growth inhibition of human cholangiocarcinoma (HCC) by gamma interferon (IFN-gamma). Tamoxifen 11-14 interferon gamma Homo sapiens 83-110 12114286-1 2002 Recent evidence indicates that glucocorticoids and catecholamines, the major stress hormones, inhibit the production of proinflammatory cytokines, such as interleukin (IL)-12, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, whereas they stimulate the production of antiinflammatory cytokines, such as IL-10, IL-4, and transforming growth factor (TGF)-beta. Catecholamines 51-65 interferon gamma Homo sapiens 215-237 12035045-0 2002 Tamoxifen (TMX)/Fas induced growth inhibition of human cholangiocarcinoma (HCC) by gamma interferon (IFN-gamma). ammonium ferrous sulfate 16-19 interferon gamma Homo sapiens 83-110 12035045-1 2002 OBJECTIVES: To evaluate the response of human cholangoicarcinoma cells to TMX treatment through the Fas pathway by pretreatment with IFN-gamma. Tamoxifen 74-77 interferon gamma Homo sapiens 133-142 12049792-1 2002 7,8-Dihydroneopterin and neopterin are secreted by human and primate macrophages after activation by interferon-gamma in a ratio of 2:1. 7,8-dihydroneopterin 0-20 interferon gamma Homo sapiens 101-117 12049792-1 2002 7,8-Dihydroneopterin and neopterin are secreted by human and primate macrophages after activation by interferon-gamma in a ratio of 2:1. Neopterin 11-20 interferon gamma Homo sapiens 101-117 12021072-8 2002 IFN-gamma and TNFalpha promote Fas expression and sensitivity, whereas IL-6 and IL-10 increase the resistance of trophoblast cells to Fas-mediated apoptosis. ammonium ferrous sulfate 31-34 interferon gamma Homo sapiens 0-9 12173304-6 2002 We then observed that gamma delta T cells activated by the synthetic phosphoantigen bromohydrin pyrophosphate (BrHPP) induced the production of IL-12 (p40) and IL-12 (p70) by DC, an effect that involved IFN-gamma production. phosphoantigen bromohydrin pyrophosphate 69-109 interferon gamma Homo sapiens 203-212 12173304-6 2002 We then observed that gamma delta T cells activated by the synthetic phosphoantigen bromohydrin pyrophosphate (BrHPP) induced the production of IL-12 (p40) and IL-12 (p70) by DC, an effect that involved IFN-gamma production. bromohydrin pyrophosphate 111-116 interferon gamma Homo sapiens 203-212 12114305-12 2002 Other studies suggest that estradiol is more inhibitory to Thl cytokines (e.g., IFNgamma, IL-2), while testosterone is inhibitory to Th2 cytokines (e.g., IL-4). Estradiol 27-36 interferon gamma Homo sapiens 80-88 12107440-10 2002 The histone deacetylase inhibitor Trichostatin A did not alter SNRPN expression, but did reverse silencing of IFNG in a MECP2-mutant-expressing clone. trichostatin A 34-48 interferon gamma Homo sapiens 110-114 12060397-8 2002 The apoptotic rates both in normal melanocytes and in two melanoma cell lines (SK-Mel-19 and O-Mel-2) were increased by treatment with tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharides; however, these effects could not be prevented by the specific nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine. omega-N-Methylarginine 301-327 interferon gamma Homo sapiens 164-180 12021433-0 2002 Structural features of interferon-gamma aggregation revealed by hydrogen exchange. Hydrogen 64-72 interferon gamma Homo sapiens 23-39 12021433-1 2002 Using hydrogen-deuterium exchange (HX) and electrospray ionization mass spectrometry, we have investigated the stability and structural changes of recombinant human interferon-gamma (IFN-gamma) during aggregation induced by guanidine hydrochloride (GdnHCl) and potassium thiocyanate. Guanidine 224-247 interferon gamma Homo sapiens 165-181 12021433-1 2002 Using hydrogen-deuterium exchange (HX) and electrospray ionization mass spectrometry, we have investigated the stability and structural changes of recombinant human interferon-gamma (IFN-gamma) during aggregation induced by guanidine hydrochloride (GdnHCl) and potassium thiocyanate. Guanidine 224-247 interferon gamma Homo sapiens 183-192 12021433-4 2002 In 1 M GdnHCl, the stability of IFN-gamma was greatly reduced and much less protection from HX in solution was observed. Guanidine 7-13 interferon gamma Homo sapiens 32-41 12021433-8 2002 These results show that helix C, which forms the hydrophobic core of the IFN-gamma dimer, is highly protected from HX under native conditions, is more stable in GdnHCl than the rest of the protein and remains intact in both GdnHCl- and KSCN-induced aggregates. Guanidine 161-167 interferon gamma Homo sapiens 73-82 12021433-8 2002 These results show that helix C, which forms the hydrophobic core of the IFN-gamma dimer, is highly protected from HX under native conditions, is more stable in GdnHCl than the rest of the protein and remains intact in both GdnHCl- and KSCN-induced aggregates. Guanidine 224-230 interferon gamma Homo sapiens 73-82 12021433-8 2002 These results show that helix C, which forms the hydrophobic core of the IFN-gamma dimer, is highly protected from HX under native conditions, is more stable in GdnHCl than the rest of the protein and remains intact in both GdnHCl- and KSCN-induced aggregates. potassium thiocyanate 236-240 interferon gamma Homo sapiens 73-82 11994457-4 2002 While 2DL4 can activate IFN-gamma production, dependent upon the transmembrane arginine, the function of the single ITIM of 2DL4 remains unknown. 2dl4 6-10 interferon gamma Homo sapiens 24-33 11994457-4 2002 While 2DL4 can activate IFN-gamma production, dependent upon the transmembrane arginine, the function of the single ITIM of 2DL4 remains unknown. Arginine 79-87 interferon gamma Homo sapiens 24-33 12011292-1 2002 Predose levels of neopterin decreased significantly, consistent with a long-term decrease in IFNgamma expression and macrophage activation during IFNbeta-1a treatment. Neopterin 18-27 interferon gamma Homo sapiens 93-101 12173346-6 2002 RESULTS: Under aerobic culture conditions (5% CO2 plus 21% O2) HTDEC expressed less Bcl-2 and were more susceptible to IFN-gamma-induced apoptosis with significant reductions in both cell proliferation and capillary tube formation, when compared with normal human macrovascular and microvascular EC. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 46-49 interferon gamma Homo sapiens 119-128 12173346-6 2002 RESULTS: Under aerobic culture conditions (5% CO2 plus 21% O2) HTDEC expressed less Bcl-2 and were more susceptible to IFN-gamma-induced apoptosis with significant reductions in both cell proliferation and capillary tube formation, when compared with normal human macrovascular and microvascular EC. Oxygen 47-49 interferon gamma Homo sapiens 119-128 11976279-4 2002 Pre-treatment with 1 - 10 microM atorvastatin, cerivastatin or pravastatin decreased TNFalpha plus IFNgamma stimulated iNOS expression in the endothelium irrespective of the presence of the HMG-CoA reductase product mevalonate (400 microM). Atorvastatin 33-45 interferon gamma Homo sapiens 99-107 12051768-7 2002 By contrast, PBLs stimulated with PHA or PMA + ionomycin showed a biphasic expression with a sharp increase at 6 h. This induction was closely parallel to IFN-gamma expression and partially to IL-4 and IL-10. Ionomycin 47-56 interferon gamma Homo sapiens 155-164 11983250-6 2002 The stimulation of Vgamma9Vdelta2 T cells with phosphocarbohydrates induces the production of cytokines (IFNgamma and TNFalpha) and the release of chemokines with suppressive activity on HIV replication. phosphocarbohydrates 47-67 interferon gamma Homo sapiens 105-113 11991881-4 2002 Exhaled IFN-gamma was significantly lower in steroid-naive and steroid-treated children with asthma compared with normal control subjects (3.7 +/- 0.2 versus 5.1 +/- 0.4 pg/ml, p < 0.01 and 4.1 versus 5.1 pg/ml, p < 0.05). Steroids 45-52 interferon gamma Homo sapiens 8-17 11991881-4 2002 Exhaled IFN-gamma was significantly lower in steroid-naive and steroid-treated children with asthma compared with normal control subjects (3.7 +/- 0.2 versus 5.1 +/- 0.4 pg/ml, p < 0.01 and 4.1 versus 5.1 pg/ml, p < 0.05). Steroids 63-70 interferon gamma Homo sapiens 8-17 11991881-7 2002 The IL-4/IFN-gamma ratio was significantly greater in children with asthma compared with control children and the children with asthma on inhaled steroid therapy. Steroids 146-153 interferon gamma Homo sapiens 9-18 11976279-4 2002 Pre-treatment with 1 - 10 microM atorvastatin, cerivastatin or pravastatin decreased TNFalpha plus IFNgamma stimulated iNOS expression in the endothelium irrespective of the presence of the HMG-CoA reductase product mevalonate (400 microM). cerivastatin 47-59 interferon gamma Homo sapiens 99-107 11976279-4 2002 Pre-treatment with 1 - 10 microM atorvastatin, cerivastatin or pravastatin decreased TNFalpha plus IFNgamma stimulated iNOS expression in the endothelium irrespective of the presence of the HMG-CoA reductase product mevalonate (400 microM). Pravastatin 63-74 interferon gamma Homo sapiens 99-107 11976279-6 2002 Neutralization of these transcription factors by employing the corresponding decoy oligonucleotides confirmed their involvement in TNFalpha plus IFNgamma stimulated iNOS expression. Oligonucleotides 83-99 interferon gamma Homo sapiens 145-153 11941456-11 2002 IFN-gamma also enhanced the ADCC of cG250 throughout the study period, but was not as effective as the IL-2 treatment, and the SK-RC-09 line displayed lower specific cytotoxicity than the SK-RC-52 cell line. G250 monoclonal antibody 36-41 interferon gamma Homo sapiens 0-9 12027418-2 2002 Kaempferol suppressed IFN-gamma and IL-2 production but not that of IL-4 by T cells and shifted the Th1/Th2 balance into the Th2 phenotype. kaempferol 0-10 interferon gamma Homo sapiens 22-31 12020259-5 2002 Methylprednisolone was also able to significantly (P<.03) reduce the number of PBMNCs from healthy controls migrating through interferon-gamma-stimulated or unstimulated endothelium. Methylprednisolone 0-18 interferon gamma Homo sapiens 129-145 11985524-3 2002 Median levels of IFN-gamma and TNF-alpha in T1R patients fell during treatment with steroids; however, TNF-alpha levels increased as the steroid dose was reduced. Steroids 84-92 interferon gamma Homo sapiens 17-26 11985524-3 2002 Median levels of IFN-gamma and TNF-alpha in T1R patients fell during treatment with steroids; however, TNF-alpha levels increased as the steroid dose was reduced. Steroids 84-91 interferon gamma Homo sapiens 17-26 12063186-8 2002 In the phytohemagglutinin-stimulated CBL culture system, when the IGF-IR antisense oligonucleotide existed, the mRNA levels of IFN gamma and IL-2 decreased 30-50% and IL-4 decreased 20-30%. Oligonucleotides 83-98 interferon gamma Homo sapiens 127-136 12027422-0 2002 Nitric oxide attenuates beryllium-induced IFNgamma responses in chronic beryllium disease: evidence for mechanisms independent of IL-18. Nitric Oxide 0-12 interferon gamma Homo sapiens 42-50 12027422-0 2002 Nitric oxide attenuates beryllium-induced IFNgamma responses in chronic beryllium disease: evidence for mechanisms independent of IL-18. Beryllium 24-33 interferon gamma Homo sapiens 42-50 12027422-0 2002 Nitric oxide attenuates beryllium-induced IFNgamma responses in chronic beryllium disease: evidence for mechanisms independent of IL-18. Beryllium 72-81 interferon gamma Homo sapiens 42-50 12027422-1 2002 In chronic beryllium disease (CBD), a granulomatous lung disease characterized by hypersensitivity to beryllium salts (BE), BE challenge of bronchoalveolar lavage cells induces IFNgamma. Beryllium 11-20 interferon gamma Homo sapiens 177-185 12027422-1 2002 In chronic beryllium disease (CBD), a granulomatous lung disease characterized by hypersensitivity to beryllium salts (BE), BE challenge of bronchoalveolar lavage cells induces IFNgamma. beryllium salts 102-117 interferon gamma Homo sapiens 177-185 12027422-1 2002 In chronic beryllium disease (CBD), a granulomatous lung disease characterized by hypersensitivity to beryllium salts (BE), BE challenge of bronchoalveolar lavage cells induces IFNgamma. Beryllium 119-121 interferon gamma Homo sapiens 177-185 12027422-3 2002 Here we report that BE-stimulated IFNgamma production in CBD lavage cells was markedly reduced (74%) by the NO generator DETA NONOate. 2,2'-(hydroxynitrosohydrazono)bis-ethanamine 121-133 interferon gamma Homo sapiens 34-42 12037399-10 2002 Furthermore, calcitriol also decreased the secretion of IL-2 and IFN-gamma by Th1 clones, and of IL-4 by Th2 clones. Calcitriol 13-23 interferon gamma Homo sapiens 65-74 12150539-3 2002 Human macrophages stimulated by interferon-gamma generate reactive oxygen species (ROS), neopterin, and 7,8-dihydroneopterin. Reactive Oxygen Species 58-81 interferon gamma Homo sapiens 32-48 12150539-3 2002 Human macrophages stimulated by interferon-gamma generate reactive oxygen species (ROS), neopterin, and 7,8-dihydroneopterin. Reactive Oxygen Species 83-86 interferon gamma Homo sapiens 32-48 12150539-3 2002 Human macrophages stimulated by interferon-gamma generate reactive oxygen species (ROS), neopterin, and 7,8-dihydroneopterin. Neopterin 89-98 interferon gamma Homo sapiens 32-48 12150539-3 2002 Human macrophages stimulated by interferon-gamma generate reactive oxygen species (ROS), neopterin, and 7,8-dihydroneopterin. 7,8-dihydroneopterin 104-124 interferon gamma Homo sapiens 32-48 12037399-7 2002 RESULTS: Calcitriol significantly inhibited the production of IL-2, IFN-gamma and IL-12 by PBMC, as well as the percentage of CD4+ T cells containing intracytoplasmic IL-2 and IFN-gamma. Calcitriol 9-19 interferon gamma Homo sapiens 68-77 11943326-4 2002 Furthermore, huIL-18 showed a dose-dependent induction of IFN-gamma production in PBMC in the presence of a constant concentration of huIL-12. huil-12 134-141 interferon gamma Homo sapiens 58-67 12073618-3 2002 At the time of diagnosis, IFN-gamma production by CD4+ T cells in either tuberculosis patients without DM (TB) or with DM was significantly lower than that in the healthy control. Terbium 107-109 interferon gamma Homo sapiens 26-35 12073618-4 2002 CD4+ T cells in tuberculosis patients with DM under poor control (DM(p)TB) produced significantly less IFN-gamma than did patients with DM under good control (DM(g)TB). Terbium 71-73 interferon gamma Homo sapiens 103-112 12073618-5 2002 In longitudinal studies, IFN-gamma production in both TB and DM(g)TB patients returned to the control level by 6 months, whereas the production in DM(p)TB patients remained depressed. Terbium 54-56 interferon gamma Homo sapiens 25-34 12073618-5 2002 In longitudinal studies, IFN-gamma production in both TB and DM(g)TB patients returned to the control level by 6 months, whereas the production in DM(p)TB patients remained depressed. Terbium 66-68 interferon gamma Homo sapiens 25-34 12073618-5 2002 In longitudinal studies, IFN-gamma production in both TB and DM(g)TB patients returned to the control level by 6 months, whereas the production in DM(p)TB patients remained depressed. Terbium 66-68 interferon gamma Homo sapiens 25-34 12066846-7 2002 Nitrostyrene treatment of macrophages, stimulated with IFN gamma and LPS, resulted in a dose dependent differential inhibition in IL12, IL6 and nitrite production, even using doses < 0.5 microg/mL. nitrostyrene 0-12 interferon gamma Homo sapiens 55-64 12066846-7 2002 Nitrostyrene treatment of macrophages, stimulated with IFN gamma and LPS, resulted in a dose dependent differential inhibition in IL12, IL6 and nitrite production, even using doses < 0.5 microg/mL. Nitrites 144-151 interferon gamma Homo sapiens 55-64 11971025-5 2002 We found that PPAR alpha ligands (clofibrate and WY14643) enhanced IL-1 beta-induced COX-2 expression in human astrocytes and microglia, while inhibiting IL-1 beta plus IFN-gamma induction of iNOS in astrocytes. Clofibrate 34-44 interferon gamma Homo sapiens 169-178 11971025-5 2002 We found that PPAR alpha ligands (clofibrate and WY14643) enhanced IL-1 beta-induced COX-2 expression in human astrocytes and microglia, while inhibiting IL-1 beta plus IFN-gamma induction of iNOS in astrocytes. pirinixic acid 49-56 interferon gamma Homo sapiens 169-178 12060498-6 2002 In PBMC stimulated with lypopolysaccharide (LPS) or in whole blood stimulated with Staphylococcus epidermidis, 3 nM IL-18BP reduced IFN-gamma by 80%, whereas IL-18Ralpha:Fc had no effect. lypopolysaccharide 24-42 interferon gamma Homo sapiens 132-141 11961080-5 2002 The IC(50) for IL-5 and IL-13 in TPA/ionomycin-stimulated peripheral blood mononuclear cells (PBMC) is 0.7 +/- 0.1 and 0.5 +/- 0.1 microM, respectively, whereas the IC(50) for IFN-gamma is 2.0 +/- 0.4 microM. Ionomycin 37-46 interferon gamma Homo sapiens 176-185 11972023-0 2002 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma. Serine 41-44 interferon gamma Homo sapiens 80-89 12018856-2 2002 Although STAT1 activation is primarily induced upon tyrosine phosphorylation by Jak1 and Jak2 (the IFN-gamma receptor-associated tyrosine kinases), the full activation of STAT1 is thought to involve serine phosphorylation by unidentified protein kinases. Serine 199-205 interferon gamma Homo sapiens 99-108 12009845-5 2002 The addition of IL-1 beta, TNF-alpha, and IFN-gamma together increased nitrite production: 257.5 +/- 35.8 % and S-nitrosothiol production : 413 +/- 29%, P < 0.001. Nitrites 71-78 interferon gamma Homo sapiens 42-51 12009845-5 2002 The addition of IL-1 beta, TNF-alpha, and IFN-gamma together increased nitrite production: 257.5 +/- 35.8 % and S-nitrosothiol production : 413 +/- 29%, P < 0.001. S-Nitrosothiols 112-126 interferon gamma Homo sapiens 42-51 12018856-2 2002 Although STAT1 activation is primarily induced upon tyrosine phosphorylation by Jak1 and Jak2 (the IFN-gamma receptor-associated tyrosine kinases), the full activation of STAT1 is thought to involve serine phosphorylation by unidentified protein kinases. Tyrosine 52-60 interferon gamma Homo sapiens 99-108 12018856-8 2002 This would contribute to the enhanced tyrosine phosphorylation, nuclear translocation, and DNA-binding of STAT1 upon exposure of the cells to IFN-gamma in the Ras-transformed cells. Tyrosine 38-46 interferon gamma Homo sapiens 142-151 12017196-5 2002 Moreover, 10(-4 M NaVO3 significantly reduced the release of IFN-gamma by PHA-stimulated PBMCs, and 10(-7) M NaVO3 significantly enhanced the release of TNF-alpha. Vanadates 18-23 interferon gamma Homo sapiens 61-70 12096925-3 2002 We found that interferon-gamma (IFN-gamma) treatment increased the presence of high molecular weight forms of CD95 in these cells as judged by Western analysis, and treatment of protein extracts with Peptide: N -glycosidase F indicated that the majority of high molecular weight forms were due to N-linked glycosylation. Nitrogen 34-35 interferon gamma Homo sapiens 14-30 12096925-6 2002 Treatment with DMM, a mannosidase inhibitor, efficiently reduced the appearance of high molecular weight forms of CD95 after IFN-gamma treatment, and sensitized SEM and REH cells to CD95-mediated death. 1-Deoxynojirimycin 15-18 interferon gamma Homo sapiens 125-134 12096925-7 2002 However, the IFN-gamma-induced increases of CD95 on the cell surface were not altered by treatment with any of the glycosidase inhibitors, suggesting that the generation of complex oligosaccharide structures is not required for trafficking of CD95, but may instead be used as a mechanism of partially blocking CD95 signalling in these cells. Oligosaccharides 181-196 interferon gamma Homo sapiens 13-22 11911993-0 2002 Increased production of nitric oxide stimulated by interferon-gamma from peripheral blood monocytes in patients with complex regional pain syndrome. Nitric Oxide 24-36 interferon gamma Homo sapiens 51-67 11911993-1 2002 This study examines immediate nitric oxide (NO) release from monocytes following interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) challenge in patients with complex regional pain syndrome (CRPS). Nitric Oxide 30-42 interferon gamma Homo sapiens 111-127 11911993-1 2002 This study examines immediate nitric oxide (NO) release from monocytes following interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) challenge in patients with complex regional pain syndrome (CRPS). Nitric Oxide 30-42 interferon gamma Homo sapiens 129-138 12020636-8 2002 Consequently, CLA decreased the production of PGE(2), TNFalpha and the inflammatory agent nitric oxide (NO) in RAW cells treated with IFN gamma. Linoleic Acids, Conjugated 14-17 interferon gamma Homo sapiens 134-143 12020636-8 2002 Consequently, CLA decreased the production of PGE(2), TNFalpha and the inflammatory agent nitric oxide (NO) in RAW cells treated with IFN gamma. Prostaglandins E 46-49 interferon gamma Homo sapiens 134-143 12020636-8 2002 Consequently, CLA decreased the production of PGE(2), TNFalpha and the inflammatory agent nitric oxide (NO) in RAW cells treated with IFN gamma. Nitric Oxide 90-102 interferon gamma Homo sapiens 134-143 11934839-7 2002 Pretreatment of cells with well-established PPARalpha (WY14643 or fenofibrate) or PPARgamma (BRL49653/rosiglitazone or pioglitazone) activators reduced anti-CD3-induced IFNgamma secretion in a concentration-dependent manner. Rosiglitazone 102-115 interferon gamma Homo sapiens 169-177 11948463-4 2002 Incubation of IFN-gamma-primed MonoMac-6 cells with serum-opsonized zymosan or EGP-2-directed, mouse IgG2a-opsonized, EGP-2-positive tumor cells resulted in the production of ROS and TNF-alpha and induced E-selectin and ICAM-1 expression on HUVECs. Zymosan 68-75 interferon gamma Homo sapiens 14-23 11948463-4 2002 Incubation of IFN-gamma-primed MonoMac-6 cells with serum-opsonized zymosan or EGP-2-directed, mouse IgG2a-opsonized, EGP-2-positive tumor cells resulted in the production of ROS and TNF-alpha and induced E-selectin and ICAM-1 expression on HUVECs. ros 175-178 interferon gamma Homo sapiens 14-23 11897677-3 2002 The dsRNA, tested as synthetic poly(IC) (PIC), in synergism with the proinflammatory cytokines interferon-gamma (IFN-gamma) and/or IL-1 beta, results in nitric oxide production, Fas expression, beta-cell dysfunction, and death. Nitric Oxide 153-165 interferon gamma Homo sapiens 95-111 11897677-3 2002 The dsRNA, tested as synthetic poly(IC) (PIC), in synergism with the proinflammatory cytokines interferon-gamma (IFN-gamma) and/or IL-1 beta, results in nitric oxide production, Fas expression, beta-cell dysfunction, and death. Nitric Oxide 153-165 interferon gamma Homo sapiens 113-122 11991629-3 2002 We found that butyrate at the six tested concentrations induced a significant decrease (P < 0.001) in the stimulated release of TNF-alpha, IFN-gamma, and IL-12, whereas IL-6 release was not altered. Butyrates 14-22 interferon gamma Homo sapiens 142-151 11991629-4 2002 At concentrations > or = 0.25 mM, butyrate significantly reduced the stimulated release of IL-5, IL-10, and IL-13; the stimulated release of IFN-gamma, IL-12, IL-5, and IL-13 was nearly abolished when compared to the unstimulated control sample. Butyrates 37-45 interferon gamma Homo sapiens 144-153 11985668-3 2002 This immuno-inhibitory phenotype was further shown to result from induction of the tryptophan-catabolizing enzyme, indoleamine 2,3-dioxygenase (IDO), by interferon-gamma (IFN-gamma) secreted from cocultured allo-reactive PBL. Tryptophan 83-93 interferon gamma Homo sapiens 153-169 11994141-5 2002 In contrast, lesional skin exposed to RA showed an almost 90% increase in CRBPI transcripts but unaltered expression of CRABPI and CRABPII, yet, the mRNA expression of several inflammatory mediators, e.g. inducible nitric oxide synthase, interferon-gamma and interleukin-1beta, was clearly reduced. Radium 38-40 interferon gamma Homo sapiens 238-254 11985668-3 2002 This immuno-inhibitory phenotype was further shown to result from induction of the tryptophan-catabolizing enzyme, indoleamine 2,3-dioxygenase (IDO), by interferon-gamma (IFN-gamma) secreted from cocultured allo-reactive PBL. Tryptophan 83-93 interferon gamma Homo sapiens 171-180 11941321-9 2002 In patients with CIU there was a T(H)0 cytokine profile, with significant increases in IL-4 (P =.0029), IL-5 (P =.0025), and IFN-gamma (P =.037) mRNA(+) cells. n-cyclohexyl-n'-(4-iodophenyl)urea 17-20 interferon gamma Homo sapiens 125-134 11909970-7 2002 Stat1-VDR interactions, by preventing Stat1 deactivation by tyrosine dephosphorylation, cooperate with IFN-gamma/Stat1-induced transcription. Tyrosine 60-68 interferon gamma Homo sapiens 103-112 11999357-0 2002 Successful immunosuppressive therapy with cyclosporine A for posthepatitis B-cell deficiency with activated cytoplasmic interferon--gamma-positive T-lymphocytes. Cyclosporine 42-56 interferon gamma Homo sapiens 120-137 12699837-3 2002 METHODS: Stainless-steel (316-l) disks were coated with fibrin meshwork containing IFN-gamma or IFN-alpha. Stainless Steel 9-24 interferon gamma Homo sapiens 83-92 11907163-12 2002 Glibenclamide also suppressed IFN-gamma-induced up-regulation of major histocompatibility complex II. Glyburide 0-13 interferon gamma Homo sapiens 30-39 12019734-5 2002 This study demonstrates for the first time that "in vitro" pretreatment with gentamicin-killed H. pylori of PBMC, followed by infection with live bacteria, downregulates the production of inflammatory cytokines such as IL-18 and IFNgamma Our results provide a possible strategy to restore the immunological disorders determined by H. pylori infection. Gentamicins 77-87 interferon gamma Homo sapiens 229-237 11967122-7 2002 Assessment of the frequencies of interleukin (IL)-10 and interferon (IFN)-gamma-producing cells in in vitro-cultivated PBMCs showed that the ratio between pro- and anti-inflammatory cytokines changed after exposure to chloroquine, favouring anti-inflammatory immune responses. Chloroquine 218-229 interferon gamma Homo sapiens 57-79 12687266-0 2002 Up-regulation of interferon-gamma production by reduced glutathione, anthocyane and L-cysteine treatment in children with allergic asthma and recurrent respiratory diseases. Glutathione 56-67 interferon gamma Homo sapiens 17-33 12013392-0 2002 Histamine influences the expression of IFN-gamma in atopic and nonatopic human Th1 cell cultures. Histamine 0-9 interferon gamma Homo sapiens 39-48 11799107-6 2002 THP-1 cells stimulated with interferon-gamma alone showed increased pteridine synthesis by addition of phenylalanine to the culture medium. Pteridines 68-77 interferon gamma Homo sapiens 28-44 12687266-0 2002 Up-regulation of interferon-gamma production by reduced glutathione, anthocyane and L-cysteine treatment in children with allergic asthma and recurrent respiratory diseases. anthocyane 69-79 interferon gamma Homo sapiens 17-33 12687266-0 2002 Up-regulation of interferon-gamma production by reduced glutathione, anthocyane and L-cysteine treatment in children with allergic asthma and recurrent respiratory diseases. Cysteine 84-94 interferon gamma Homo sapiens 17-33 12687266-3 2002 Use of reduced glutathione, L-cysteine and anthocyane (Recancostat, Clear Vision, Switzerland) resulted in elevation of IFN-gamma production, lymphocyte response to mitogens, NK cell activity, increase in percentage of naive CD4(+) T lymphocytes (refreshment effect) and improvement of clinical status. Glutathione 15-26 interferon gamma Homo sapiens 120-129 12687266-3 2002 Use of reduced glutathione, L-cysteine and anthocyane (Recancostat, Clear Vision, Switzerland) resulted in elevation of IFN-gamma production, lymphocyte response to mitogens, NK cell activity, increase in percentage of naive CD4(+) T lymphocytes (refreshment effect) and improvement of clinical status. Cysteine 28-38 interferon gamma Homo sapiens 120-129 12687266-3 2002 Use of reduced glutathione, L-cysteine and anthocyane (Recancostat, Clear Vision, Switzerland) resulted in elevation of IFN-gamma production, lymphocyte response to mitogens, NK cell activity, increase in percentage of naive CD4(+) T lymphocytes (refreshment effect) and improvement of clinical status. anthocyane 43-53 interferon gamma Homo sapiens 120-129 12687266-3 2002 Use of reduced glutathione, L-cysteine and anthocyane (Recancostat, Clear Vision, Switzerland) resulted in elevation of IFN-gamma production, lymphocyte response to mitogens, NK cell activity, increase in percentage of naive CD4(+) T lymphocytes (refreshment effect) and improvement of clinical status. recancostat 55-66 interferon gamma Homo sapiens 120-129 11799107-6 2002 THP-1 cells stimulated with interferon-gamma alone showed increased pteridine synthesis by addition of phenylalanine to the culture medium. Phenylalanine 103-116 interferon gamma Homo sapiens 28-44 11799107-7 2002 Cells stimulated with interferon-gamma plus LPS, in contrast, showed phenylalanine-independent pteridine synthesis. Phenylalanine 69-82 interferon gamma Homo sapiens 22-38 11799107-7 2002 Cells stimulated with interferon-gamma plus LPS, in contrast, showed phenylalanine-independent pteridine synthesis. Pteridines 95-104 interferon gamma Homo sapiens 22-38 11751854-13 2002 Consistent with these data, in 3T3-F442A adipocytes, endogenous APS was tyrosyl-phosphorylated in response to GH and interferon-gamma. Adenosine Phosphosulfate 64-67 interferon gamma Homo sapiens 117-133 11884427-4 2002 By contrast, IFN-alpha, IFN-gamma, and TGF-beta were identified as negative regulators of DC-SIGN expression, as they prevented the IL-4-dependent induction of DC-SIGN mRNA on monocytes, and a similar inhibitory effect was exerted by dexamethasone, an inhibitor of the monocyte-MDDC differentiation pathway. Dexamethasone 234-247 interferon gamma Homo sapiens 24-33 11867742-7 2002 Human peripheral blood mononuclear cells stimulated with LPS in the presence of SAHA released less TNF-alpha, IL-1-beta, IL-12, and IFN-gamma (50% reduction at 100-200 nM). Vorinostat 80-84 interferon gamma Homo sapiens 132-141 11923705-0 2002 Modulation of IFN-gamma-induced immunogenicity by phosphatidylethanolamine-linked hyaluronic acid. phosphatidylethanolamine 50-74 interferon gamma Homo sapiens 14-23 11923705-0 2002 Modulation of IFN-gamma-induced immunogenicity by phosphatidylethanolamine-linked hyaluronic acid. Hyaluronic Acid 82-97 interferon gamma Homo sapiens 14-23 11923705-1 2002 BACKGROUND: The present study was conducted to examine the possibility of modulating interferon (IFN-gamma)-induced immunogenicity by a novel compound that is composed of a PLA2 inhibitor linked to hyaluronic acid (HYPE). Hyaluronic Acid 198-213 interferon gamma Homo sapiens 85-106 11751854-13 2002 Consistent with these data, in 3T3-F442A adipocytes, endogenous APS was tyrosyl-phosphorylated in response to GH and interferon-gamma. cyclo(tyrosyl-tyrosyl) 72-79 interferon gamma Homo sapiens 117-133 11751911-4 2002 Tyrosine kinase inhibitors (genistein or herbimycin), Src family inhibitor (PP2), or a phosphatidylinositol-phospholipase C inhibitor (U73122) attenuated the IFN-gamma-induced ICAM-1 expression. Genistein 28-37 interferon gamma Homo sapiens 158-167 11966768-2 2002 THI was characterized by an increased frequency of CD3+/CD4+ lymphocytes expressing tumour necrosis factor alpha (TNF-alpha), TNF-beta and interleukin 10 (IL-10), while in SIgAD elevated numbers of these cells containing TNF-alpha and interferon gamma (IFN-gamma) were observed. 2-acetyl-4(5)-tetrahydroxybutylimidazole 0-3 interferon gamma Homo sapiens 235-262 11861526-0 2002 High glucose levels increase major histocompatibility complex class I gene expression in thyroid cells and amplify interferon-gamma action. Glucose 5-12 interferon gamma Homo sapiens 115-131 11886435-3 2002 As shown by several groups, iron also modulates immune effector mechanisms, such as cytokine activities (IFN-gamma effector pathways towards macrophages), nitric oxide (NO) formation or immune cell proliferation, and thus host immune surveillance. Iron 28-32 interferon gamma Homo sapiens 105-114 11874895-2 2002 We hypothesize that the flavonoid constituents of a proprietary grape seed extract (GSE) that contains procyandins exert significant antiviral and antitumor effects, by inducing production of the Th1-derived cytokine gamma interferon (IFN-gamma) by peripheral blood mononuclear cells) from healthy donors. Flavonoids 24-33 interferon gamma Homo sapiens 217-244 11874895-2 2002 We hypothesize that the flavonoid constituents of a proprietary grape seed extract (GSE) that contains procyandins exert significant antiviral and antitumor effects, by inducing production of the Th1-derived cytokine gamma interferon (IFN-gamma) by peripheral blood mononuclear cells) from healthy donors. procyandins 103-114 interferon gamma Homo sapiens 217-244 11914744-11 2002 CONCLUSION/INTERPRETATION: IFN gamma and TNFalpha synergistically induced MHC class II expression on insulinoma cells through the induction of CIITA; nicotinamide reduced the expression of cytokine-induced MHC class II expression on insulinoma cells through its effect on CIITA expression; and the preventive effect of nicotimamide on Type I (insulin-dependent) diabetes mellitus is probably due to its effect of MHC class II expression rather than that on islet cell apoptosis. Niacinamide 150-162 interferon gamma Homo sapiens 27-36 11914744-11 2002 CONCLUSION/INTERPRETATION: IFN gamma and TNFalpha synergistically induced MHC class II expression on insulinoma cells through the induction of CIITA; nicotinamide reduced the expression of cytokine-induced MHC class II expression on insulinoma cells through its effect on CIITA expression; and the preventive effect of nicotimamide on Type I (insulin-dependent) diabetes mellitus is probably due to its effect of MHC class II expression rather than that on islet cell apoptosis. nicotimamide 319-331 interferon gamma Homo sapiens 27-36 11751911-9 2002 The IFN-gamma-induced ICAM-1 promoter activity was inhibited by tyrosine kinase inhibitors, a phosphatidylinositol-phospholipase C inhibitor, or PKC inhibitors, and the TPA-induced ICAM-1 promoter activity was also inhibited by tyrosine kinase inhibitors. Tetradecanoylphorbol Acetate 169-172 interferon gamma Homo sapiens 4-13 11751911-13 2002 An immunocomplex kinase assay showed that both IFN-gamma and TPA activated c-Src and Lyn activities and that these effects were inhibited by staurosporine and herbimycin. Staurosporine 141-154 interferon gamma Homo sapiens 47-56 11751911-13 2002 An immunocomplex kinase assay showed that both IFN-gamma and TPA activated c-Src and Lyn activities and that these effects were inhibited by staurosporine and herbimycin. herbimycin 159-169 interferon gamma Homo sapiens 47-56 11751911-4 2002 Tyrosine kinase inhibitors (genistein or herbimycin), Src family inhibitor (PP2), or a phosphatidylinositol-phospholipase C inhibitor (U73122) attenuated the IFN-gamma-induced ICAM-1 expression. herbimycin 41-51 interferon gamma Homo sapiens 158-167 11751911-4 2002 Tyrosine kinase inhibitors (genistein or herbimycin), Src family inhibitor (PP2), or a phosphatidylinositol-phospholipase C inhibitor (U73122) attenuated the IFN-gamma-induced ICAM-1 expression. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 135-141 interferon gamma Homo sapiens 158-167 11751911-5 2002 Protein kinase C (PKC) inhibitors (staurosporine or Ro 31-8220) also inhibited IFN-gamma-induced response. Staurosporine 35-48 interferon gamma Homo sapiens 79-88 11751911-5 2002 Protein kinase C (PKC) inhibitors (staurosporine or Ro 31-8220) also inhibited IFN-gamma-induced response. Ro 31-8220 52-62 interferon gamma Homo sapiens 79-88 11897990-12 2002 (R)-Albuterol at 10(-8) mol/L inhibited IL-2 and IFN-gamma production. Levalbuterol 0-13 interferon gamma Homo sapiens 49-58 11874235-8 2002 Interleukin-1alpha (IL-1alpha) and interferon gamma (IFN-gamma) but not tumor necrosis factor alpha (TNF-alpha) also significantly increased nitrotyrosine expression in these cells. 3-nitrotyrosine 141-154 interferon gamma Homo sapiens 35-62 11859140-1 2002 Treatment of cultured primary human thyroid cells with IFN-gamma and TNF-alpha uniquely allows the induction of Fas-mediated apoptosis. ammonium ferrous sulfate 112-115 interferon gamma Homo sapiens 55-64 11958824-0 2002 Interferon-gamma-induced calcium influx in T lymphocytes of multiple sclerosis and rheumatoid arthritis patients: a complementary mechanism for T cell activation? Calcium 25-32 interferon gamma Homo sapiens 0-16 11839400-6 2002 Non-pregnant women with RSA showed a significantly lower expression of IFN-gamma compared to the non-pregnant control group. rabbit sperm membrane autoantigen 24-27 interferon gamma Homo sapiens 71-80 11897996-10 2002 However, lidocaine inhibited, in a dose-dependent manner, the proliferative response and mRNA expression and protein production of IL-5 and IFN-gamma of PBMCs stimulated with D farinae, purified protein derivatives, or phorbol 12-myristate 13-acetate plus calcium ionophore. Lidocaine 9-18 interferon gamma Homo sapiens 140-149 11975681-0 2002 Activity of ALRT 1550, a new retinoid, with interferon-gamma on ovarian cancer cell lines. Retinoids 29-37 interferon gamma Homo sapiens 44-60 11975681-6 2002 Because interferon (IFN)-gamma was found to synergistically amplify the growth inhibition of retinoids in cultured breast cancer cells, we investigated the combination of ALRT 1550 with IFN-gamma in two ovarian cancer cell lines. Retinoids 93-102 interferon gamma Homo sapiens 8-30 11975681-7 2002 ALRT 1550 (5 microM) in combination with IFN-gamma at a concentration of 500 U/ml inhibited cell growth of SKOV-3 by as much as 81% (CI = 1.88). skov-3 107-113 interferon gamma Homo sapiens 41-50 12014425-5 2002 Interferon-gamma production was determined in the supernatant by ELISA and the induction of apoptosis by flow cytometry after propidium iodide staining. Propidium 126-142 interferon gamma Homo sapiens 0-16 11858710-7 2002 Introduction of the intramolecular disulfide bond together with C-terminal shortening and replacement of C-terminal residue was shown to result in increasing the thermal stability by 19 degrees C and four times enhancement of biological activity compared with intact IFN-gamma molecule. Disulfides 35-44 interferon gamma Homo sapiens 267-276 11940238-6 2002 Our results demonstrated a significant decrease in the production of IL-2, IFN-gamma and IL-10 (P < 0.005) in response to rHB antigen. rhb 125-128 interferon gamma Homo sapiens 75-84 11830474-0 2002 Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide. alpha-galactosylceramide 133-157 interferon gamma Homo sapiens 25-41 11836620-1 2002 Pentoxifylline (PTX) is commonly used in peripheral blood vessel diseases, however it has also been found to decrease the level of proinflammatory cytokines such as IL-12, TNF-alpha and IFN-gamma. Pentoxifylline 0-14 interferon gamma Homo sapiens 186-195 11836620-1 2002 Pentoxifylline (PTX) is commonly used in peripheral blood vessel diseases, however it has also been found to decrease the level of proinflammatory cytokines such as IL-12, TNF-alpha and IFN-gamma. Pentoxifylline 16-19 interferon gamma Homo sapiens 186-195 11829656-0 2002 Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-gamma-activated RAW 264.7 macrophages. Anthocyanins 22-34 interferon gamma Homo sapiens 98-107 11829656-0 2002 Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-gamma-activated RAW 264.7 macrophages. Nitric Oxide 67-79 interferon gamma Homo sapiens 98-107 11804875-6 2002 Further, we investigated the molecular mechanisms underlying the effects of HGF and IFN-gamma in BEAS-2B cells and found that the MEK1 inhibitor PD98059, but not the p38 M-associated protein kinase inhibitor SB203580, abrogates HGF-induced ERK activation and proliferation in response to HGF and serum. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 145-152 interferon gamma Homo sapiens 84-93 11876754-8 2002 We also showed that nine out of 12 patients investigated presented an increase of urinary neopterin, a marker of IFN-gamma-activated macrophages, 7 days after MAK instillation, while serum neopterin levels were almost stable. Neopterin 90-99 interferon gamma Homo sapiens 113-122 11840449-7 2002 The ability of dexamethasone and ASA to suppress IFNgamma and interleukin-1beta (IL-1beta) messenger RNA and protein production was also tested in vitro using T cell clones and monocytes derived from patients with GCA. Dexamethasone 15-28 interferon gamma Homo sapiens 49-57 11840449-7 2002 The ability of dexamethasone and ASA to suppress IFNgamma and interleukin-1beta (IL-1beta) messenger RNA and protein production was also tested in vitro using T cell clones and monocytes derived from patients with GCA. Aspirin 33-36 interferon gamma Homo sapiens 49-57 11733495-9 2002 Taken together, these results indicate that PPARgamma is targeted to the ubiquitin-proteasome pathway for degradation under basal conditions and that IFNgamma leads to an increased targeting of PPARgamma to the ubiquitin-proteasome system in a process that is affected by ERK-regulated serine phosphorylation of PPARgamma proteins. Serine 286-292 interferon gamma Homo sapiens 150-158 11788558-3 2002 Furthermore, we assessed the IFN-gamma inducible molecule neopterin and nitrite/nitrate serum levels, which are indicative of endogenous nitric oxide formation. Nitric Oxide 137-149 interferon gamma Homo sapiens 29-38 11880162-4 2002 These effects on IFN-gamma production were significantly (p<0.001) inhibited by a GH antagonist, suggesting that L-GH was acting by an autocrine or paracrine mechanism to enhance IFN-gamma production in these serum-free cultured cells. l-gh 116-120 interferon gamma Homo sapiens 17-26 12022445-7 2002 YH-Tang significantly inhibited interleukin (IL)-1, IL-4, IL-6 and tumor necrosis factor-alpha (TNF-alpha) secretion in astrocytes stimulated with SP and LPS, but did not inhibit interferon-y (IFN-gamma) and IL-2 secretion significantly. yh-tang 0-7 interferon gamma Homo sapiens 193-202 11892896-2 2002 At therapeutic concentrations, quinolones superinduce interleukin-2 (IL-2) and interferon-gamma production by mitogen-activated human peripheral blood T lymphocytes. Quinolones 31-41 interferon gamma Homo sapiens 79-95 11818456-5 2002 Furthermore, IFN-gamma priming increased the GSH/GSSG ratio and enhanced IL-12 production through p38, and DEM negated the priming effect of IFN-gamma on p38 activation and IL-12 production as well as on the GSH/GSSG ratio. Glutathione 45-48 interferon gamma Homo sapiens 13-22 11818456-5 2002 Furthermore, IFN-gamma priming increased the GSH/GSSG ratio and enhanced IL-12 production through p38, and DEM negated the priming effect of IFN-gamma on p38 activation and IL-12 production as well as on the GSH/GSSG ratio. Glutathione Disulfide 49-53 interferon gamma Homo sapiens 13-22 11818456-5 2002 Furthermore, IFN-gamma priming increased the GSH/GSSG ratio and enhanced IL-12 production through p38, and DEM negated the priming effect of IFN-gamma on p38 activation and IL-12 production as well as on the GSH/GSSG ratio. Glutathione 208-211 interferon gamma Homo sapiens 13-22 11818456-5 2002 Furthermore, IFN-gamma priming increased the GSH/GSSG ratio and enhanced IL-12 production through p38, and DEM negated the priming effect of IFN-gamma on p38 activation and IL-12 production as well as on the GSH/GSSG ratio. Glutathione 208-211 interferon gamma Homo sapiens 141-150 11818456-5 2002 Furthermore, IFN-gamma priming increased the GSH/GSSG ratio and enhanced IL-12 production through p38, and DEM negated the priming effect of IFN-gamma on p38 activation and IL-12 production as well as on the GSH/GSSG ratio. Glutathione Disulfide 212-216 interferon gamma Homo sapiens 13-22 11818456-5 2002 Furthermore, IFN-gamma priming increased the GSH/GSSG ratio and enhanced IL-12 production through p38, and DEM negated the priming effect of IFN-gamma on p38 activation and IL-12 production as well as on the GSH/GSSG ratio. Glutathione Disulfide 212-216 interferon gamma Homo sapiens 141-150 11818456-6 2002 These findings reveal that glutathione redox regulates LPS-induced IL-12 production from monocytes through p38 MAP kinase activation and that the priming effect of IFN-gamma on IL-12 production is partly a result of the glutathione redox balance. Glutathione 220-231 interferon gamma Homo sapiens 164-173 12075858-1 2002 Large amounts of neopterin are produced by interferon-(IFN)-gamma-stimulated human monocytes/macrophages, and increased neopterin concentrations indicate cellular immune activation. Neopterin 17-26 interferon gamma Homo sapiens 43-65 12075858-2 2002 In parallel, IFN-gamma induces indoleamine 2,3-dioxygenase which degrades 1-tryptophan to kynurenine. 1-tryptophan 74-86 interferon gamma Homo sapiens 13-22 12075858-2 2002 In parallel, IFN-gamma induces indoleamine 2,3-dioxygenase which degrades 1-tryptophan to kynurenine. Kynurenine 90-100 interferon gamma Homo sapiens 13-22 11880162-4 2002 These effects on IFN-gamma production were significantly (p<0.001) inhibited by a GH antagonist, suggesting that L-GH was acting by an autocrine or paracrine mechanism to enhance IFN-gamma production in these serum-free cultured cells. l-gh 116-120 interferon gamma Homo sapiens 182-191 11835212-0 2002 A new mechanism for decreasing aggregation of recombinant human interferon-gamma by a surfactant: slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20. Polysorbates 176-190 interferon gamma Homo sapiens 64-80 11832212-5 2002 Nonphosphorylatable mutant eIF2alpha, knockout of PKR and PKR inhibitors 2-aminopurine, transdominant-negative PKR, or vaccinia E3L correspondingly enhances translation of IFN-gamma mRNA. 2-Aminopurine 73-86 interferon gamma Homo sapiens 172-181 11801647-9 2002 Functionally, heparin-treated DCs respond to LPS or LPS plus IFN-gamma with higher IL-10 and less IL-12 production than heparin-untreated DCs. Heparin 14-21 interferon gamma Homo sapiens 61-70 11801647-9 2002 Functionally, heparin-treated DCs respond to LPS or LPS plus IFN-gamma with higher IL-10 and less IL-12 production than heparin-untreated DCs. Heparin 120-127 interferon gamma Homo sapiens 61-70 11812275-7 2002 The circulating mIL-12 activated natural killer cells and stimulated IFN-gamma production in vivo. mil-12 16-22 interferon gamma Homo sapiens 69-78 11872013-3 2002 Neopterin (NEOP) is a metabolite derived from guanosine triphosphate with the production and release of NEOP being induced in monocytes and macrophages by cytokines such as interferon-gamma (IFN-gamma). Neopterin 0-9 interferon gamma Homo sapiens 173-189 12774392-4 2002 RESULT: The LBZ injection could promote IFN-alpha, IFN-gamma, TNF-alpha inductions of PBMCs, but had no effect on IL-8. lbz 12-15 interferon gamma Homo sapiens 51-60 12402613-14 2002 When cells were stimulated by ionomicin and phorbol 12-myristate 13-acetate (PMA), more IFN-gamma appeared and high levels of IL-4 persisted in 75% of the samples, which looked like intent to correct the TH2 immunodeviation toward TH0. ionomicin 30-39 interferon gamma Homo sapiens 88-97 12402613-14 2002 When cells were stimulated by ionomicin and phorbol 12-myristate 13-acetate (PMA), more IFN-gamma appeared and high levels of IL-4 persisted in 75% of the samples, which looked like intent to correct the TH2 immunodeviation toward TH0. Tetradecanoylphorbol Acetate 44-75 interferon gamma Homo sapiens 88-97 12402613-14 2002 When cells were stimulated by ionomicin and phorbol 12-myristate 13-acetate (PMA), more IFN-gamma appeared and high levels of IL-4 persisted in 75% of the samples, which looked like intent to correct the TH2 immunodeviation toward TH0. Tetradecanoylphorbol Acetate 77-80 interferon gamma Homo sapiens 88-97 11751204-4 2002 In this investigation we demonstrate that interferon (IFN)-gamma and interleukin (IL)-1beta have opposing effects on Fas-mediated apoptosis in A549 cells, a human lung epithelial cell line. ammonium ferrous sulfate 117-120 interferon gamma Homo sapiens 42-64 11890524-6 2002 Tx-CsA-treatment abrogated the IBDV-induced inflammatory response and significantly (P < 0.05) reduced the incidence of apoptotic bursa cells and the expression of cytokines such as interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) in comparison to T cell-intact birds. Cyclosporine 3-6 interferon gamma Homo sapiens 228-237 12774392-2 2002 METHOD: The amounts of IFN-alpha, IFN-gamma, TNF-alpha, IL-8 in the peripheral blood mononuclear cells(PBMCs) culture supernatants deal with by different concentrations of LianBiZhi (LBZ) injection made of andrographolide were detected by biological activity test or ELISA in vitro. lianbizhi 172-181 interferon gamma Homo sapiens 34-43 11886166-7 2002 The biological activity of purified vIL-10 was demonstrated through its ability to inhibit interferon gamma (IFN-gamma) production by mitogen activated peripheral blood mononuclear cells and to down-regulate HLA-class II expression on activated monocytes/macrophages. vil-10 36-42 interferon gamma Homo sapiens 91-118 12477274-2 2002 METHODS AND RESULTS: Exposure of cord and adult macrophages to IFN-gamma gave quantitatively different results in Candida killing, as well as in release of superoxide anion (O2-). Superoxides 156-172 interferon gamma Homo sapiens 63-72 12477274-2 2002 METHODS AND RESULTS: Exposure of cord and adult macrophages to IFN-gamma gave quantitatively different results in Candida killing, as well as in release of superoxide anion (O2-). Superoxides 174-176 interferon gamma Homo sapiens 63-72 11751214-3 2002 Human bronchial epithelial cells stimulated with 50 ng/ml interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma express iNOS mRNA, protein and increased nitrite in the cell culture media, which was inhibited by the selective iNOS inhibitor 1400W. Nitrites 168-175 interferon gamma Homo sapiens 110-126 11751214-3 2002 Human bronchial epithelial cells stimulated with 50 ng/ml interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma express iNOS mRNA, protein and increased nitrite in the cell culture media, which was inhibited by the selective iNOS inhibitor 1400W. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 255-260 interferon gamma Homo sapiens 110-126 12371620-4 2002 Th1 producing IFN-gamma induce EAU development, while Th2 producing IL-4/IL-10 prevent the disease. Water 31-34 interferon gamma Homo sapiens 14-23 11872013-3 2002 Neopterin (NEOP) is a metabolite derived from guanosine triphosphate with the production and release of NEOP being induced in monocytes and macrophages by cytokines such as interferon-gamma (IFN-gamma). Neopterin 0-9 interferon gamma Homo sapiens 191-200 11872013-3 2002 Neopterin (NEOP) is a metabolite derived from guanosine triphosphate with the production and release of NEOP being induced in monocytes and macrophages by cytokines such as interferon-gamma (IFN-gamma). Neopterin 11-15 interferon gamma Homo sapiens 173-189 11872013-3 2002 Neopterin (NEOP) is a metabolite derived from guanosine triphosphate with the production and release of NEOP being induced in monocytes and macrophages by cytokines such as interferon-gamma (IFN-gamma). Neopterin 11-15 interferon gamma Homo sapiens 191-200 11872013-3 2002 Neopterin (NEOP) is a metabolite derived from guanosine triphosphate with the production and release of NEOP being induced in monocytes and macrophages by cytokines such as interferon-gamma (IFN-gamma). Guanosine Triphosphate 46-68 interferon gamma Homo sapiens 173-189 11872013-3 2002 Neopterin (NEOP) is a metabolite derived from guanosine triphosphate with the production and release of NEOP being induced in monocytes and macrophages by cytokines such as interferon-gamma (IFN-gamma). Guanosine Triphosphate 46-68 interferon gamma Homo sapiens 191-200 11872013-3 2002 Neopterin (NEOP) is a metabolite derived from guanosine triphosphate with the production and release of NEOP being induced in monocytes and macrophages by cytokines such as interferon-gamma (IFN-gamma). Neopterin 104-108 interferon gamma Homo sapiens 173-189 11872013-3 2002 Neopterin (NEOP) is a metabolite derived from guanosine triphosphate with the production and release of NEOP being induced in monocytes and macrophages by cytokines such as interferon-gamma (IFN-gamma). Neopterin 104-108 interferon gamma Homo sapiens 191-200 14660054-0 2002 Increased IFN-gamma synthesis by T cells from patients on imatinib therapy for chronic myeloid leukemia. Imatinib Mesylate 58-66 interferon gamma Homo sapiens 10-19 14660054-12 2002 In conclusion, treatment with imatinib achieves a significant increase in Type 1 (IFN-gamma) cytokine-producing T cells in patients with CML. Imatinib Mesylate 30-38 interferon gamma Homo sapiens 82-91 11772508-5 2002 The percentages of CD3+ cells producing TNF-alpha and IFN-gamma were significantly higher in elderly compared to young people (p=0.0049; p=0.0026, respectively) after stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 184-187 interferon gamma Homo sapiens 54-63 12112628-7 2002 Exposure to tetrachloroethylene was associated with reduced percentages of interferon-gamma-producing (IFN-gamma) type 1 T cells (OR = 2.9). Tetrachloroethylene 12-31 interferon gamma Homo sapiens 75-112 12112629-0 2002 The mycotoxins citrinin, gliotoxin, and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells. Citrinin 15-23 interferon gamma Homo sapiens 55-71 12112629-0 2002 The mycotoxins citrinin, gliotoxin, and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells. Gliotoxin 25-34 interferon gamma Homo sapiens 55-71 12112629-7 2002 The strongest inhibition of cytokine expression was found for IFN-gamma: 8.3 microg/mL citrinin, 34.2 ng/mL gliotoxin, and 64.8 ng/mL patulin caused a 50% inhibition of the IFN-gamma release (50% inhibitory dose, ID(50)). Citrinin 87-95 interferon gamma Homo sapiens 62-71 12112629-7 2002 The strongest inhibition of cytokine expression was found for IFN-gamma: 8.3 microg/mL citrinin, 34.2 ng/mL gliotoxin, and 64.8 ng/mL patulin caused a 50% inhibition of the IFN-gamma release (50% inhibitory dose, ID(50)). Citrinin 87-95 interferon gamma Homo sapiens 173-182 11784307-2 2002 Here, we investigate the involvement of death-associated protein (DAP) kinase, initially identified as a positive mediator of the interferon-gamma-induced apoptosis of HeLa cells, in the C(2)-ceramide-induced apoptosis of PC12 cells. A(2)C 187-191 interferon gamma Homo sapiens 130-146 11784307-2 2002 Here, we investigate the involvement of death-associated protein (DAP) kinase, initially identified as a positive mediator of the interferon-gamma-induced apoptosis of HeLa cells, in the C(2)-ceramide-induced apoptosis of PC12 cells. Ceramides 192-200 interferon gamma Homo sapiens 130-146 11804830-3 2002 beta2 microglobulin (BMG), neopterin and soluble (s) Fas increased with IFN-alpha and increased more with IFN-gamma. ammonium ferrous sulfate 53-56 interferon gamma Homo sapiens 106-115 11772508-5 2002 The percentages of CD3+ cells producing TNF-alpha and IFN-gamma were significantly higher in elderly compared to young people (p=0.0049; p=0.0026, respectively) after stimulation with PMA and ionomycin. Ionomycin 192-201 interferon gamma Homo sapiens 54-63 11752021-4 2002 The induction of IP-10 and Mig mRNA and protein expression by IFN-gamma plus TNF-alpha was strongly inhibited by nitric oxide (NO) donors, such as sodium nitroprusside or S-nitroso-N-acetylpenicillamine, but not by cGMP analogues. Nitric Oxide 113-125 interferon gamma Homo sapiens 62-71 11752045-6 2002 Among recipients of DR-mismatched allografts, a cut-off value of 60 interferon-gamma spots/10(6) cells significantly (P = 0.02) separated stable patients (creatinine concentration, 1.1 +/- 0.3 mg/dl) from high-risk patients (creatinine concentration, 2.3 +/- 1.7 mg/dl). Creatinine 155-165 interferon gamma Homo sapiens 68-84 11752021-4 2002 The induction of IP-10 and Mig mRNA and protein expression by IFN-gamma plus TNF-alpha was strongly inhibited by nitric oxide (NO) donors, such as sodium nitroprusside or S-nitroso-N-acetylpenicillamine, but not by cGMP analogues. Nitroprusside 147-167 interferon gamma Homo sapiens 62-71 11752021-4 2002 The induction of IP-10 and Mig mRNA and protein expression by IFN-gamma plus TNF-alpha was strongly inhibited by nitric oxide (NO) donors, such as sodium nitroprusside or S-nitroso-N-acetylpenicillamine, but not by cGMP analogues. S-Nitroso-N-Acetylpenicillamine 171-202 interferon gamma Homo sapiens 62-71 11752021-4 2002 The induction of IP-10 and Mig mRNA and protein expression by IFN-gamma plus TNF-alpha was strongly inhibited by nitric oxide (NO) donors, such as sodium nitroprusside or S-nitroso-N-acetylpenicillamine, but not by cGMP analogues. Cyclic GMP 215-219 interferon gamma Homo sapiens 62-71 11752045-6 2002 Among recipients of DR-mismatched allografts, a cut-off value of 60 interferon-gamma spots/10(6) cells significantly (P = 0.02) separated stable patients (creatinine concentration, 1.1 +/- 0.3 mg/dl) from high-risk patients (creatinine concentration, 2.3 +/- 1.7 mg/dl). Creatinine 225-235 interferon gamma Homo sapiens 68-84 11813269-0 2002 Characterization of interferon gamma receptors on osteoclasts: effect of interferon gamma on osteoclastic superoxide generation. Superoxides 106-116 interferon gamma Homo sapiens 20-36 11813269-0 2002 Characterization of interferon gamma receptors on osteoclasts: effect of interferon gamma on osteoclastic superoxide generation. Superoxides 106-116 interferon gamma Homo sapiens 73-89 11813269-6 2002 Specific binding of IFN-gamma to the osteoclastic receptor stimulates osteoclastic superoxide generation. Superoxides 83-93 interferon gamma Homo sapiens 20-29 11813269-7 2002 The p91 and p47 components of the NADPH oxidase increase after IFN-gamma stimulation and may account for the enhanced superoxide generation. Superoxides 118-128 interferon gamma Homo sapiens 63-72 11813269-8 2002 Antisense experiments targeting p91 and p47 subunits abrogate the increased osteoclastic superoxide production stimulated by IFN-gamma. Superoxides 89-99 interferon gamma Homo sapiens 125-134 11813269-9 2002 Thus, superoxide generation by osteoclasts is stimulated by activation of a functional IFN-gamma receptor on the osteoclast. Superoxides 6-16 interferon gamma Homo sapiens 87-96 12112002-0 2002 Nitric oxide and prostaglandin E2 participate in lipopolysaccharide/interferon-gamma-induced heme oxygenase 1 and prevent RAW264.7 macrophages from UV-irradiation-induced cell death. Nitric Oxide 0-12 interferon gamma Homo sapiens 68-84 11948692-6 2002 The DNA fragmentation and DAPI staining assays suggested that the IFN-gamma-mediated cytotoxicity could be triggered by apoptosis. DAPI 26-30 interferon gamma Homo sapiens 66-75 12112002-0 2002 Nitric oxide and prostaglandin E2 participate in lipopolysaccharide/interferon-gamma-induced heme oxygenase 1 and prevent RAW264.7 macrophages from UV-irradiation-induced cell death. Dinoprostone 17-33 interferon gamma Homo sapiens 68-84 12112002-6 2002 And, NSAIDs aspirin and diclofenase dose dependently inhibited LPS/IFN-gamma-induced HO-1 protein accompanied by suppression of PGE(2) (not NO) production. diclofenase 24-35 interferon gamma Homo sapiens 67-76 12112002-6 2002 And, NSAIDs aspirin and diclofenase dose dependently inhibited LPS/IFN-gamma-induced HO-1 protein accompanied by suppression of PGE(2) (not NO) production. Prostaglandins E 128-131 interferon gamma Homo sapiens 67-76 11716958-0 2002 Inhibition of type 2,5"-deiodinase by tumor necrosis factor alpha, interleukin-6 and interferon gamma in human thyroid tissue. type 2,5"-deiodinase 14-34 interferon gamma Homo sapiens 85-101 12112002-4 2002 In the presence of lipopolysaccharide and interferon-gamma (LPS/IFN-gamma), HO-1 protein was induced slightly but significantly, and SNP, SP-NO, and PGE(2) enhanced HO-1 protein induced by LPS/IFN-gamma. sp-no 138-143 interferon gamma Homo sapiens 42-58 12112002-4 2002 In the presence of lipopolysaccharide and interferon-gamma (LPS/IFN-gamma), HO-1 protein was induced slightly but significantly, and SNP, SP-NO, and PGE(2) enhanced HO-1 protein induced by LPS/IFN-gamma. sp-no 138-143 interferon gamma Homo sapiens 64-73 12112002-4 2002 In the presence of lipopolysaccharide and interferon-gamma (LPS/IFN-gamma), HO-1 protein was induced slightly but significantly, and SNP, SP-NO, and PGE(2) enhanced HO-1 protein induced by LPS/IFN-gamma. sp-no 138-143 interferon gamma Homo sapiens 193-202 12112002-4 2002 In the presence of lipopolysaccharide and interferon-gamma (LPS/IFN-gamma), HO-1 protein was induced slightly but significantly, and SNP, SP-NO, and PGE(2) enhanced HO-1 protein induced by LPS/IFN-gamma. Prostaglandins E 149-152 interferon gamma Homo sapiens 42-58 12112002-4 2002 In the presence of lipopolysaccharide and interferon-gamma (LPS/IFN-gamma), HO-1 protein was induced slightly but significantly, and SNP, SP-NO, and PGE(2) enhanced HO-1 protein induced by LPS/IFN-gamma. Prostaglandins E 149-152 interferon gamma Homo sapiens 64-73 12112002-4 2002 In the presence of lipopolysaccharide and interferon-gamma (LPS/IFN-gamma), HO-1 protein was induced slightly but significantly, and SNP, SP-NO, and PGE(2) enhanced HO-1 protein induced by LPS/IFN-gamma. Prostaglandins E 149-152 interferon gamma Homo sapiens 193-202 12112002-5 2002 L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production. Arginine 0-10 interferon gamma Homo sapiens 137-146 12112002-5 2002 L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production. n-nitro-l-arginine methyl ester 19-50 interferon gamma Homo sapiens 137-146 12112002-5 2002 L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production. NG-Nitroarginine Methyl Ester 52-58 interferon gamma Homo sapiens 137-146 12112002-5 2002 L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production. Nitroarginine 19-37 interferon gamma Homo sapiens 137-146 12112002-5 2002 L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production. Nitroarginine 84-87 interferon gamma Homo sapiens 137-146 11916128-0 2002 Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes. Histamine 0-9 interferon gamma Homo sapiens 75-84 12112002-5 2002 L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production. Prostaglandins E 185-188 interferon gamma Homo sapiens 137-146 11916128-9 2002 Interestingly, IFN-gamma and IL-4 both significantly augmented the histamine-induced IL-6 production. Histamine 67-76 interferon gamma Homo sapiens 15-24 12112002-6 2002 And, NSAIDs aspirin and diclofenase dose dependently inhibited LPS/IFN-gamma-induced HO-1 protein accompanied by suppression of PGE(2) (not NO) production. Aspirin 12-19 interferon gamma Homo sapiens 67-76 11916128-10 2002 On the other hand, the production of IL-8 was inhibited by IFN-gamma, and IFN-gamma and IL-4 both completely abrogated the histamine-induced IL-8 production. Histamine 123-132 interferon gamma Homo sapiens 74-83 11851874-4 2002 Interferon-gamma increased hyaluronan production whereas transforming growth factor beta decreased it. Hyaluronic Acid 27-37 interferon gamma Homo sapiens 0-16 11916128-11 2002 These results suggest that the histamine-induced IL-6 production and IL-8 production are differentially regulated by IFN-gamma and IL-4. Histamine 31-40 interferon gamma Homo sapiens 117-126 11751951-1 2002 In this study, we show that binding to autologous dendritic cells (DC) induces a calcium influx in NK cells, followed by activation of the calcium-calmodulin kinase II (CAMKII), release of perforin and granzymes, and IFN-gamma secretion. Calcium 81-88 interferon gamma Homo sapiens 217-226 11751951-4 2002 NK cell-mediated lysis of DC and IFN-gamma release by NK cells upon NK/DC contact are inhibited by exogenous HIV-1 Tat: the protein blocks calcium influx and impairs CAMKII activation elicited via LFA-1 in NK cells, eventually inhibiting degranulation. Calcium 139-146 interferon gamma Homo sapiens 33-42 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 42-51 interferon gamma Homo sapiens 168-177 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 interferon gamma Homo sapiens 168-177 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 interferon gamma Homo sapiens 168-177 11781358-5 2002 Whereas a biased Th1 to Th2 cytokine profile has been suggested to underlie the pathogenesis of IMD in both species, we found defective production of IFN-gamma in our patients after in vitro stimulation of their PBMCs by phorbol-myristate acetate and ionomycin and both IFN-gamma and IL-4 deficiencies in V(alpha)24(+) NK T-enriched cells. Tetradecanoylphorbol Acetate 221-246 interferon gamma Homo sapiens 150-159 11781358-5 2002 Whereas a biased Th1 to Th2 cytokine profile has been suggested to underlie the pathogenesis of IMD in both species, we found defective production of IFN-gamma in our patients after in vitro stimulation of their PBMCs by phorbol-myristate acetate and ionomycin and both IFN-gamma and IL-4 deficiencies in V(alpha)24(+) NK T-enriched cells. Tetradecanoylphorbol Acetate 221-246 interferon gamma Homo sapiens 270-279 11781358-5 2002 Whereas a biased Th1 to Th2 cytokine profile has been suggested to underlie the pathogenesis of IMD in both species, we found defective production of IFN-gamma in our patients after in vitro stimulation of their PBMCs by phorbol-myristate acetate and ionomycin and both IFN-gamma and IL-4 deficiencies in V(alpha)24(+) NK T-enriched cells. Ionomycin 251-260 interferon gamma Homo sapiens 150-159 11752121-4 2002 The inhibition of IL-18-induced IFN-gamma by histamine was ascribed to the strong inhibition of IL-12 production by histamine. Histamine 45-54 interferon gamma Homo sapiens 32-41 11752121-4 2002 The inhibition of IL-18-induced IFN-gamma by histamine was ascribed to the strong inhibition of IL-12 production by histamine. Histamine 116-125 interferon gamma Homo sapiens 32-41 11739521-5 2001 IFN-gamma-primed DLD-1 cells stimulated with 1 microg/ml of 6HIS flag induced high levels of NO (60 +/- 0.95 microM) comparable to the combination of IL-1beta and IFN-gamma (77 +/- 1.2) or purified native SD flag (66.3 +/- 0.98). 6his 60-64 interferon gamma Homo sapiens 0-9 15080501-0 2002 Cocaine increases intracellular calcium in the interferon-gamma-primed macrophages but not in the LPS-primed-macrophages. Cocaine 0-7 interferon gamma Homo sapiens 47-63 15080501-0 2002 Cocaine increases intracellular calcium in the interferon-gamma-primed macrophages but not in the LPS-primed-macrophages. Calcium 32-39 interferon gamma Homo sapiens 47-63 15080501-4 2002 We report here that cocaine increases the IFN-gamma-primed macrophage [Ca2+]i, but it does not affect the LPS-primed macrophage [Ca2+]i. Cocaine 20-27 interferon gamma Homo sapiens 42-51 11739196-3 2001 EMSA demonstrated a significant increase in LIL-STAT binding to the LILRE oligonucleotides after interferon gamma (IFN-gamma) and IL-6 stimulation of THP-1 cells. Oligonucleotides 74-90 interferon gamma Homo sapiens 97-124 11739524-8 2001 IFN-gamma-mediated IL-18BPa and its suppression by sodium butyrate were confirmed in organ cultures of intestinal colonic biopsy specimens. Butyric Acid 51-66 interferon gamma Homo sapiens 0-9 11739521-5 2001 IFN-gamma-primed DLD-1 cells stimulated with 1 microg/ml of 6HIS flag induced high levels of NO (60 +/- 0.95 microM) comparable to the combination of IL-1beta and IFN-gamma (77 +/- 1.2) or purified native SD flag (66.3 +/- 0.98). 6his 60-64 interferon gamma Homo sapiens 163-172 11733570-5 2001 Both, IL-10 production before and IFN-gamma production after Cy-treatment by TIMs required T cells. tims 77-81 interferon gamma Homo sapiens 34-43 11577084-1 2001 Signal transduction via the interferon-gamma (IFN-gamma) receptor requires the tyrosine phosphorylation of signal transducers and activators of transcription (Stats). Tyrosine 79-87 interferon gamma Homo sapiens 28-44 11577084-1 2001 Signal transduction via the interferon-gamma (IFN-gamma) receptor requires the tyrosine phosphorylation of signal transducers and activators of transcription (Stats). Tyrosine 79-87 interferon gamma Homo sapiens 46-55 11577084-4 2001 In transfection assays both Stat5 isoforms, Stat5a and Stat5b, were phosphorylated on tyrosine in response to IFN-gamma. Tyrosine 86-94 interferon gamma Homo sapiens 110-119 11795279-0 2001 Lysophosphatidylcholine inhibits T cell-specific CXC chemokines IP-10, MIG, and I-TAC expression induced by IFN-gamma in human endothelial cells. Lysophosphatidylcholines 0-23 interferon gamma Homo sapiens 108-117 11781510-0 2001 Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNgamma levels. Alcohols 45-52 interferon gamma Homo sapiens 169-177 11781510-14 2001 We found reduced IFNgamma, elevated IL-10, and unchanged IL-4 levels during T-cell proliferation in samples obtained 18 hr after alcohol consumption. Alcohols 129-136 interferon gamma Homo sapiens 17-25 11781510-17 2001 Increased IL-10 and IL-13 plus the reduced IFNgamma production after acute alcohol use are likely to contribute to both the reduced T-cell proliferation and monocyte accessory cell function. Alcohols 75-82 interferon gamma Homo sapiens 43-51 11736742-8 2001 In PMBCs from healthy persons, IgE class-switching may occur later and block the effects of treatment with IFN-gamma. pmbcs 3-8 interferon gamma Homo sapiens 107-116 11739141-2 2001 The purpose of this study was to examine whether interferon (IFN)-gamma, a cytokine upregulated in asthmatic airways, modulates leukotriene (LT)D4 receptor expression and contractile responses in cultured human airway smooth muscle (HASM) cells. Leukotrienes 128-139 interferon gamma Homo sapiens 49-71 11795279-4 2001 It also inhibited IP-10 protein secretion in conditioned media induced by IFN-gamma or IFN-y plus TNF-alpha Western analysis demonstrated that Lyso-PC inhibited IFN-gamma-induced STAT-1alpha protein expression, but not that of IRF-1. Lysophosphatidylcholines 143-150 interferon gamma Homo sapiens 74-83 11795279-4 2001 It also inhibited IP-10 protein secretion in conditioned media induced by IFN-gamma or IFN-y plus TNF-alpha Western analysis demonstrated that Lyso-PC inhibited IFN-gamma-induced STAT-1alpha protein expression, but not that of IRF-1. Lysophosphatidylcholines 143-150 interferon gamma Homo sapiens 87-92 11817676-2 2001 In human monocytes/macrophages, interferon-gamma induces increased production of neopterin and an enhanced activity of indoleamine 2,3-dioxygenase, which degrades tryptophan via the kynurenine pathway. Neopterin 81-90 interferon gamma Homo sapiens 32-48 11745388-8 2001 Electrophoretic mobility shift assays reveal nuclear binding complexes involving both Bf-GAS and Bf-ISRE oligonucleotide sequences upon IFN-gamma stimulation. -isre oligonucleotide 99-120 interferon gamma Homo sapiens 136-145 11745388-11 2001 Western analysis confirms an IFN-gamma-stimulated increase in tyrosine phosphorylation of Stat1. Tyrosine 62-70 interferon gamma Homo sapiens 29-38 11798468-2 2001 The kynurenine pathway (KP) is chiefly activated by IFN-gamma and IFN-alpha, leading to the production of a variety of neurotoxins. Kynurenine 4-14 interferon gamma Homo sapiens 52-61 11737052-5 2001 We compared interleukin (IL)-4, IL-12 and interferon (IFN)-gamma-producing CBMC from children with double atopic heredity (dh), maternal atopic heredity only (mh) or no atopic heredity (nh). cbmc 75-79 interferon gamma Homo sapiens 42-64 11737052-7 2001 In response to PHA, the frequency of IL-4-producing cells, as well as the ratio of IL-4/IFN-gamma-producing cells, were significantly higher in the dh group compared to the nh group. 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole 148-150 interferon gamma Homo sapiens 88-97 11737052-9 2001 Our results suggest that there is a stronger Th2 bias after in vitro stimulation of CBMC from children with atopic heredity, as reflected by higher IL-4/IFN-gamma ratios in response to PHA, and lower numbers of IL-12-producing cells after allergen stimulation. cbmc 84-88 interferon gamma Homo sapiens 153-162 11743142-4 2001 Addition of DHEA to KLH-primed splenocytes stimulated Th2 response, indicated by an increase of IL-4 or a decrease of IFN-gamma production in the cultures. Dehydroepiandrosterone 12-16 interferon gamma Homo sapiens 118-127 11739557-4 2001 The ability of TCCM to induce such phenotypic changes could be abrogated by neutralizing antibodies specific for CD40L, TNF-alpha, and IFN-gamma, indicating that these factors present in TCCM are mainly implicated in the maturation of DC. tccm 15-19 interferon gamma Homo sapiens 135-144 11886533-4 2001 Azole derivatives, ketoconazole, itraconazole, miconazole, and nonazole terbinafine hydrochloride, and tolnaftate reduced interleukin-4 and interleukin-5 secretion without altering that of interferon-gamma and interleukin-2 in anti-CD3/CD28-stimulated T cells from both atopic dermatitis patients and normal donors. Azoles 0-5 interferon gamma Homo sapiens 189-205 11886533-4 2001 Azole derivatives, ketoconazole, itraconazole, miconazole, and nonazole terbinafine hydrochloride, and tolnaftate reduced interleukin-4 and interleukin-5 secretion without altering that of interferon-gamma and interleukin-2 in anti-CD3/CD28-stimulated T cells from both atopic dermatitis patients and normal donors. Tolnaftate 103-113 interferon gamma Homo sapiens 189-205 11811586-5 2001 However, unlike proliferating cells, no cellular death occurred in the predominantly non-proliferating cells after the treatment of agonistic anti-CD95 antibody with cycloheximide, pretreated with interferon-gamma. Cycloheximide 166-179 interferon gamma Homo sapiens 197-213 11817676-2 2001 In human monocytes/macrophages, interferon-gamma induces increased production of neopterin and an enhanced activity of indoleamine 2,3-dioxygenase, which degrades tryptophan via the kynurenine pathway. Tryptophan 163-173 interferon gamma Homo sapiens 32-48 11817676-2 2001 In human monocytes/macrophages, interferon-gamma induces increased production of neopterin and an enhanced activity of indoleamine 2,3-dioxygenase, which degrades tryptophan via the kynurenine pathway. Kynurenine 182-192 interferon gamma Homo sapiens 32-48 11700035-0 2001 Penicillin conjugates to interferon-gamma and reduces its activity: a novel drug-cytokine interaction. Penicillins 0-10 interferon gamma Homo sapiens 25-41 11741404-5 2001 In the present study, the neuronal cell line Sk-n-sh was incubated for 12 h with the cyclooxygenase inhibitor ibuprofen and subsequently stimulated with the cytokines TNFalpha and IFNgamma. sk-n-sh 45-52 interferon gamma Homo sapiens 180-188 12687236-7 2001 The influence of cycloferon is less evident in the production of TNF-alpha, IFN-gamma and IL-4 by leukocytes at the range of the studied doses. 10-carboxymethyl-9-acridanone 17-27 interferon gamma Homo sapiens 76-85 12901109-6 2001 RESULTS: Both lovastatin and CsA inhibited PBMC proliferation, expression of IL-2 and IFN-gamma, and NK cell cytotoxicity in a dose-dependent manner. Lovastatin 14-24 interferon gamma Homo sapiens 86-95 12901109-6 2001 RESULTS: Both lovastatin and CsA inhibited PBMC proliferation, expression of IL-2 and IFN-gamma, and NK cell cytotoxicity in a dose-dependent manner. Cyclosporine 29-32 interferon gamma Homo sapiens 86-95 11717429-4 2001 In cells, SP600125 dose dependently inhibited the phosphorylation of c-Jun, the expression of inflammatory genes COX-2, IL-2, IFN-gamma, TNF-alpha, and prevented the activation and differentiation of primary human CD4 cell cultures. pyrazolanthrone 10-18 interferon gamma Homo sapiens 126-135 11742038-1 2001 The proinflammatory cytokines, interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNFalpha), and interferon gamma (IFNgamma), are cytotoxic to pancreatic islet beta cells, possibly by inducing nitric oxide and/or oxygen radical production in the beta cells. Nitric Oxide 201-213 interferon gamma Homo sapiens 105-132 11742038-1 2001 The proinflammatory cytokines, interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNFalpha), and interferon gamma (IFNgamma), are cytotoxic to pancreatic islet beta cells, possibly by inducing nitric oxide and/or oxygen radical production in the beta cells. Reactive Oxygen Species 221-235 interferon gamma Homo sapiens 105-132 11726817-7 2001 Cognate interaction between T cells and IPEC was not required for this effect, because IgG-incubated, MHC-class II-negative IPEC caused reduced IFN-gamma secretion during a response to human Epstein-Barr virus-transformed B cells. ipec 124-128 interferon gamma Homo sapiens 144-153 11764009-3 2001 The results showed that in vitro exposure to resveratrol produces a biphasic effect on the anti-CD3/anti-CD28-induced development of both IFN-gamma- IL2- and IL4-producing CD8+ and CD4+ T cells, with stimulation at low resveratrol concentrations and suppression at high concentrations. Resveratrol 45-56 interferon gamma Homo sapiens 138-147 11764009-3 2001 The results showed that in vitro exposure to resveratrol produces a biphasic effect on the anti-CD3/anti-CD28-induced development of both IFN-gamma- IL2- and IL4-producing CD8+ and CD4+ T cells, with stimulation at low resveratrol concentrations and suppression at high concentrations. Resveratrol 219-230 interferon gamma Homo sapiens 138-147 11700035-4 2001 In this study we show, by Western blotting, that the prototype beta-lactam benzylpenicillin (BP) conjugates to human IFN-gamma but not to IL-4. beta-lactam benzylpenicillin 63-91 interferon gamma Homo sapiens 117-126 11700035-4 2001 In this study we show, by Western blotting, that the prototype beta-lactam benzylpenicillin (BP) conjugates to human IFN-gamma but not to IL-4. Penicillin G 93-95 interferon gamma Homo sapiens 117-126 11700035-5 2001 The interaction of BP with IFN-gamma inhibited the cytokine"s detection by immunoassay and impaired its activity, as assessed in three different assays: upregulation of MHC molecules on monocytes plus induction of nitric oxide synthesis and expression of monocyte chemoattractant protein-1 mRNA by epithelial cells. Penicillin G 19-21 interferon gamma Homo sapiens 27-36 11700035-5 2001 The interaction of BP with IFN-gamma inhibited the cytokine"s detection by immunoassay and impaired its activity, as assessed in three different assays: upregulation of MHC molecules on monocytes plus induction of nitric oxide synthesis and expression of monocyte chemoattractant protein-1 mRNA by epithelial cells. Nitric Oxide 214-226 interferon gamma Homo sapiens 27-36 11700035-6 2001 This is the first reported example of a direct drug-cytokine interaction and suggests a mechanism by which penicillin may disrupt IFN-gamma-dependent immune responses and promote allergy. Penicillins 107-117 interferon gamma Homo sapiens 130-139 11761438-5 2001 Pretreatment of the SW480 primary colon carcinoma cell line with IFN-gamma, 5-FU, CPT-11 or CDDP enhanced ICAM-1 and Fas expression, resulting in Ag-specific CTL-mediated lysis involving Fas-dependent and -independent mechanisms. ammonium ferrous sulfate 117-120 interferon gamma Homo sapiens 65-74 11705464-7 2001 Resveratrol also inhibited the production of IFN-gamma and IL-2 by splenic lymphocytes, and the production of TNF-alpha and IL-12 by peritoneal macrophages. Resveratrol 0-11 interferon gamma Homo sapiens 45-54 11761438-5 2001 Pretreatment of the SW480 primary colon carcinoma cell line with IFN-gamma, 5-FU, CPT-11 or CDDP enhanced ICAM-1 and Fas expression, resulting in Ag-specific CTL-mediated lysis involving Fas-dependent and -independent mechanisms. ammonium ferrous sulfate 187-190 interferon gamma Homo sapiens 65-74 11761438-6 2001 In contrast, pretreatment of the SW620 metastatic isolate, derived from the same patient, with IFN-gamma, CPT-11 or CDDP, but not 5-FU, enhanced ICAM-1 expression, resulting in Ag-specific CTL-mediated lysis via Fas-independent mechanisms only. ammonium ferrous sulfate 212-215 interferon gamma Homo sapiens 95-104 11729509-8 2001 IFN-gamma-stimulated percentages of CD40+ thyrocytes and delta mean fluorescence intensity (dMF) in both thyrocyte sources were significantly reduced in the presence of 200 ng/ml oPRL (both GD and CONTROL: P < 0.01 and P < 0.05, respectively; CONTROL: P < 0.05) and 1000 ng/ml oPRL (GD: P < 0.01; CONTROL: P < 0.05). Dimethylformamide 92-95 interferon gamma Homo sapiens 0-9 11672993-3 2001 Among them, increased concentrations of neopterin have been reported, which is produced by human monocytes/macrophages upon stimulation by interferon-gamma. Neopterin 40-49 interferon gamma Homo sapiens 139-155 11703361-8 2001 While IFN-gamma secretion of CD8+ T lymphocytes of patients with allergic asthma was lower than that of healthy controls in the presence of PMA/calcium-ionophore, it was significantly elevated when compared with normal controls after stimulation with anti-CD3 antibodies. Calcium 144-151 interferon gamma Homo sapiens 6-15 11745338-2 2001 We show that an inhibitor of two isoforms of p38 MAPK, SB 203580, inhibited the antigen-initiated production of IL-12, and IFN-gamma by cultures of splenic APC and naive CD4(+) T cells. SB 203580 55-64 interferon gamma Homo sapiens 123-132 11745338-3 2001 Paradoxically, SB 203580 enhanced the LPS plus IFN-gamma-initiated production of IL-12 by peritoneal exudate macrophages, and the LPS-initiated of the production of both IL-12 and IFN-gamma by non-T non-B (scid) splenocytes. SB 203580 15-24 interferon gamma Homo sapiens 47-56 11745338-3 2001 Paradoxically, SB 203580 enhanced the LPS plus IFN-gamma-initiated production of IL-12 by peritoneal exudate macrophages, and the LPS-initiated of the production of both IL-12 and IFN-gamma by non-T non-B (scid) splenocytes. SB 203580 15-24 interferon gamma Homo sapiens 180-189 11745338-4 2001 The enhancing effect of SB 203580 on the production of IL-12 by peritoneal exudate macrophages stimulated by LPS and IFN-gamma was dose dependent (EC(50) 0.3 microM), was only seen at lower concentrations of IFN-gamma and was due, at least in part, to a dose-dependent (IC(50) 0.3 microM) inhibition of the production of IL-10. SB 203580 24-33 interferon gamma Homo sapiens 117-126 11745338-4 2001 The enhancing effect of SB 203580 on the production of IL-12 by peritoneal exudate macrophages stimulated by LPS and IFN-gamma was dose dependent (EC(50) 0.3 microM), was only seen at lower concentrations of IFN-gamma and was due, at least in part, to a dose-dependent (IC(50) 0.3 microM) inhibition of the production of IL-10. SB 203580 24-33 interferon gamma Homo sapiens 208-217 11703361-6 2001 As expected, CD8+ T lymphocytes from peripheral blood of healthy volunteers produced significantly more IFN-gamma in the presence of PMA and calcium-ionophore than after stimulation with anti-CD3 antibodies. Tetradecanoylphorbol Acetate 133-136 interferon gamma Homo sapiens 104-113 11703361-6 2001 As expected, CD8+ T lymphocytes from peripheral blood of healthy volunteers produced significantly more IFN-gamma in the presence of PMA and calcium-ionophore than after stimulation with anti-CD3 antibodies. Calcium 141-148 interferon gamma Homo sapiens 104-113 11703361-7 2001 However, in subjects with allergic asthma, IFN-gamma secretion of CD8+ T cells was significantly higher when incubated with anti-CD3 antibodies than after activation with PMA and calcium-ionophore. Tetradecanoylphorbol Acetate 171-174 interferon gamma Homo sapiens 43-52 11703361-7 2001 However, in subjects with allergic asthma, IFN-gamma secretion of CD8+ T cells was significantly higher when incubated with anti-CD3 antibodies than after activation with PMA and calcium-ionophore. Calcium 179-186 interferon gamma Homo sapiens 43-52 11703361-8 2001 While IFN-gamma secretion of CD8+ T lymphocytes of patients with allergic asthma was lower than that of healthy controls in the presence of PMA/calcium-ionophore, it was significantly elevated when compared with normal controls after stimulation with anti-CD3 antibodies. Tetradecanoylphorbol Acetate 140-143 interferon gamma Homo sapiens 6-15 11673554-4 2001 Treatment of cells with NaClO(3), an inhibitor of sulfation, prevented HA binding in a significant percentage of CD14(+) PBMC induced by TNF-alpha, LPS, IL-1beta, or IFN-gamma. Sodium Hypochlorite 24-29 interferon gamma Homo sapiens 166-175 11692091-4 2001 RESULTS: ISS induced the expression of the antiviral cytokine IFN-gamma in the lung, and this was associated with significantly reduced RSV viral titers, mucus secretion, and peribronchial inflammation. ISS 9-12 interferon gamma Homo sapiens 62-71 11728340-5 2001 Additionally, BZLF1 inhibits IFN-gamma-induced STAT1 tyrosine phosphorylation and nuclear translocation. Tyrosine 53-61 interferon gamma Homo sapiens 29-38 11673554-5 2001 Furthermore, stimulation with TNF-alpha or IFN-gamma in the presence of NaClO(3) reduced the ability of isolated CD44H to bind HA, demonstrating a direct effect of CD44H sulfation on HA binding. sodium chlorate 72-80 interferon gamma Homo sapiens 43-52 11673519-3 2001 Here, we show that human tumor cells can efficiently present aminobisphosphonate and pyrophosphomonoester compounds to gammadelta T cells, inducing specific proliferation and IFN-gamma production. aminobisphosphonate 61-80 interferon gamma Homo sapiens 175-184 11714861-3 2001 Prior studies have suggested that immune reactants play a role in the pathogenesis of atherosclerosis; we report here that immune reactants, IFN-gamma and immune complexes bound to C1q, but not interleukin-1 and tumor necrosis factor, diminish the expression of cholesterol 27-hydroxylase in human aortic endothelial cells, peripheral blood mononuclear cells, monocyte-derived macrophages, and the human monocytoid cell line THP-1. Cholesterol 262-273 interferon gamma Homo sapiens 141-150 11698497-6 2001 We conclude that caspase-8 and caspase-3 activation, but not MPTP opening, mediate Fas-induced eosinophil apoptosis and are the main targets for the protective effect of IL-5 and IFN-gamma. ammonium ferrous sulfate 83-86 interferon gamma Homo sapiens 179-188 11702012-0 2001 Ribavirin enhances interferon-gamma levels in patients with chronic hepatitis C treated with interferon-alpha. Ribavirin 0-9 interferon gamma Homo sapiens 19-35 11767050-6 2001 In addition, expression of IFN-gamma was generally reduced in the cells treated with IAMC. iamc 85-89 interferon gamma Homo sapiens 27-36 11602691-1 2001 Blockade of phosphodiesterase 4 with rolipram reduced the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-5, IL-10, and IL-2 but poorly inhibited cell proliferation and interferon-gamma (IFN-gamma) production by activated human T cells. Rolipram 37-45 interferon gamma Homo sapiens 205-214 11602691-2 2001 Addition of dibutyryl cAMP mimicked rolipram inhibitions on proliferation, IL-2, TNF-alpha, and IFN-gamma but not on IL-10 or IL-5 production. Bucladesine 12-26 interferon gamma Homo sapiens 96-105 11602691-3 2001 Moreover, the inhibitory effects of rolipram on proliferation, IFN-gamma, and TNF-alpha but not of IL-10 production can be prevented by a specific protein kinase A inhibitor. Rolipram 36-44 interferon gamma Homo sapiens 63-72 11694330-5 2001 Both in PP and SP patients, IFN-gamma and IL-10 mRNA were decreased compared to RR patients and controls. sp 15-17 interferon gamma Homo sapiens 28-37 11641425-0 2001 Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging. Methimazole 0-11 interferon gamma Homo sapiens 89-105 11641425-6 2001 Furthermore, MMI rapidly eliminates H(2)O(2) produced by IFN-gamma treatment in thyroid cells and thus inhibits the H(2)O(2)-mediated phosphorylation of tyrosine 701 in STAT1. Hydrogen Peroxide 36-44 interferon gamma Homo sapiens 57-66 11718569-15 2001 Although elevated with dexamethasone, staurosporine and hypoxia, these levels were markedly raised in cytotrophoblasts and SGHPL-4 cells following incubations with TNFalpha/IFNgamma. Staurosporine 38-51 interferon gamma Homo sapiens 173-181 11602757-5 2001 When TG cultures were treated with acyclovir for 4 days to insure uniform latency, supplementation with recombinant IFN-gamma blocked HSV-1 reactivation in 80% of cultures when endogenous CD8(+) T cells were present and significantly reduced and delayed HSV-1 reactivation when CD8(+) T cells or CD45(+) cells were depleted from the TG cultures. Acyclovir 35-44 interferon gamma Homo sapiens 116-125 11602757-6 2001 The effectiveness of recombinant IFN-gamma in blocking HSV-1 reactivation was lost when its addition to TG cultures was delayed by more than 24 h after acyclovir removal. Acyclovir 152-161 interferon gamma Homo sapiens 33-42 11583967-2 2001 In this report we demonstrate that nitric oxide-independent killing of co-cultured mesangial cells by interferon-gamma/lipopolysaccharide-activated M(phi) is suppressed by binding/ingestion of apoptotic cells and is mediated by tumor necrosis factor (TNF). Nitric Oxide 35-47 interferon gamma Homo sapiens 102-118 11594781-7 2001 We also determined if alpha-thrombin inhibits oncostatin M (OSM)-induced Stat3/Stat1, and interferon-gamma (IFN-gamma)-induced Stat1 tyrosine phosphorylation. Tyrosine 133-141 interferon gamma Homo sapiens 90-117 11718569-15 2001 Although elevated with dexamethasone, staurosporine and hypoxia, these levels were markedly raised in cytotrophoblasts and SGHPL-4 cells following incubations with TNFalpha/IFNgamma. Dexamethasone 23-36 interferon gamma Homo sapiens 173-181 11588047-6 2001 Calcium signaling selectively antagonized IL-12 production by mature DCs activated with IFN-gamma, TNF-alpha, and soluble CD40L. Calcium 0-7 interferon gamma Homo sapiens 88-97 11693999-1 2001 In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors. Tetradecanoylphorbol Acetate 108-133 interferon gamma Homo sapiens 32-48 11693999-1 2001 In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors. Tetradecanoylphorbol Acetate 108-133 interferon gamma Homo sapiens 50-59 11693999-1 2001 In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors. Tetradecanoylphorbol Acetate 135-138 interferon gamma Homo sapiens 32-48 11693999-1 2001 In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors. Tetradecanoylphorbol Acetate 135-138 interferon gamma Homo sapiens 50-59 11693999-1 2001 In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors. Ionomycin 142-151 interferon gamma Homo sapiens 32-48 11693999-1 2001 In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors. Ionomycin 142-151 interferon gamma Homo sapiens 50-59 11689197-4 2001 Trapidil did not alter CD154 expression on isolated T cells, but it diminished CD40 expression on isolated monocytes and human monocytic leukemia THP-1 cells stimulated with interferon-gamma. Trapidil 0-8 interferon gamma Homo sapiens 174-190 11678905-4 2001 Following re-stimulation in vitro with PMA and ionomycin, CD4+ T cells produced IFNgamma, TNFalpha, TNFbeta, IL-2, IL-4, IL-10 and IL-13. Tetradecanoylphorbol Acetate 39-42 interferon gamma Homo sapiens 80-88 11726135-1 2001 We isolated the lipoteichoic-acid-related molecule (OK-PSA) from OK-432, a streptococcal preparation, by affinity chromatography on CNBr-activated Sepharose-4B-bound monoclonal antibody TS-2, which neutralizes the interferon (IFN)-gamma-inducing activity of OK-432. lipoteichoic acid 16-33 interferon gamma Homo sapiens 214-236 11678905-4 2001 Following re-stimulation in vitro with PMA and ionomycin, CD4+ T cells produced IFNgamma, TNFalpha, TNFbeta, IL-2, IL-4, IL-10 and IL-13. Ionomycin 47-56 interferon gamma Homo sapiens 80-88 11587735-2 2001 Short term cultures of bone marrow derived feline macrophages stimulated with recombinant feline interferon-gamma (r-IFN-gamma) and lipopolysaccharide (LPS) were shown to produce nitric oxide. Nitric Oxide 179-191 interferon gamma Homo sapiens 97-113 11574475-3 2001 The IFNGR1 signal-transducing subunit of the IFN-gamma receptor is tyrosine phosphorylated through the chimeric receptors and the endogenous IL-6 and OSM receptors. Tyrosine 67-75 interferon gamma Homo sapiens 45-54 11683958-13 2001 Both the BM-DC and the Momicron-DC induced a strong interferon-gamma and IL-4 response. momicron 23-31 interferon gamma Homo sapiens 52-68 11564817-3 2001 beta-Oxa 21:3n-3 also inhibited the production of TNF-beta, IFN-gamma, and IL-2 by purified human T lymphocytes stimulated with PHA plus PMA, anti-CD3 plus anti-CD28 mAbs, or PMA plus A23187. beta-oxa 0-8 interferon gamma Homo sapiens 60-69 11564822-5 2001 More importantly, the suppressive effect of adenosine and CGS-21680 on IL-12 production was significantly enhanced in cells pretreated with either IL-1 (10 U/ml) or TNF-alpha (100 U/ml) but markedly attenuated in cells pretreated with IFN-gamma (100 U/ml). Adenosine 44-53 interferon gamma Homo sapiens 235-244 11564822-5 2001 More importantly, the suppressive effect of adenosine and CGS-21680 on IL-12 production was significantly enhanced in cells pretreated with either IL-1 (10 U/ml) or TNF-alpha (100 U/ml) but markedly attenuated in cells pretreated with IFN-gamma (100 U/ml). cysteinylglycine 58-61 interferon gamma Homo sapiens 235-244 11668484-0 2001 Interferon-gamma cooperates with retinoic acid and phorbol ester to induce differentiation and growth inhibition of human neuroblastoma cells. Tretinoin 33-46 interferon gamma Homo sapiens 0-16 11668484-0 2001 Interferon-gamma cooperates with retinoic acid and phorbol ester to induce differentiation and growth inhibition of human neuroblastoma cells. Phorbol Esters 51-64 interferon gamma Homo sapiens 0-16 11600182-8 2001 Since natural estrogen increases IFN-gamma, it became important to test whether diethylstilbestrol (DES, a synthetic estrogen which was given to millions of women) also alters IFN-gamma levels. Diethylstilbestrol 80-98 interferon gamma Homo sapiens 176-185 11600182-8 2001 Since natural estrogen increases IFN-gamma, it became important to test whether diethylstilbestrol (DES, a synthetic estrogen which was given to millions of women) also alters IFN-gamma levels. Diethylstilbestrol 100-103 interferon gamma Homo sapiens 176-185 11525637-8 2001 MNC chemotactic activity of conditioned medium of HUVEC stimulated with IL-1alpha or IFN-gamma was inhibited by co-treatment with sIL-6R. sil-6r 130-136 interferon gamma Homo sapiens 85-94 11438544-0 2001 Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression. Serine 97-103 interferon gamma Homo sapiens 42-58 11438544-2 2001 We show that phosphatidylinositol 3-kinase (PI3K) and its effector kinase Akt play an important role in the serine phosphorylation of STAT1 and in the activation of gene expression in response to interferon-gamma (IFN gamma). Serine 108-114 interferon gamma Homo sapiens 196-212 11438544-2 2001 We show that phosphatidylinositol 3-kinase (PI3K) and its effector kinase Akt play an important role in the serine phosphorylation of STAT1 and in the activation of gene expression in response to interferon-gamma (IFN gamma). Serine 108-114 interferon gamma Homo sapiens 214-223 11438544-7 2001 Taken together, these results suggest that the following events lead to the activation of STAT1 upon IFN gamma stimulation: 1) PI3K and Akt are activated by the occupied receptor and Tyr-440 is phosphorylated by the activated JAKs; 2) STAT1 docks to Tyr-440; and 3) Tyr-701 is phosphorylated by the JAKs and Ser-727 is phosphorylated by a kinase downstream of Akt. Tyrosine 183-186 interferon gamma Homo sapiens 101-110 11438544-7 2001 Taken together, these results suggest that the following events lead to the activation of STAT1 upon IFN gamma stimulation: 1) PI3K and Akt are activated by the occupied receptor and Tyr-440 is phosphorylated by the activated JAKs; 2) STAT1 docks to Tyr-440; and 3) Tyr-701 is phosphorylated by the JAKs and Ser-727 is phosphorylated by a kinase downstream of Akt. Tyrosine 250-253 interferon gamma Homo sapiens 101-110 11438544-7 2001 Taken together, these results suggest that the following events lead to the activation of STAT1 upon IFN gamma stimulation: 1) PI3K and Akt are activated by the occupied receptor and Tyr-440 is phosphorylated by the activated JAKs; 2) STAT1 docks to Tyr-440; and 3) Tyr-701 is phosphorylated by the JAKs and Ser-727 is phosphorylated by a kinase downstream of Akt. Tyrosine 250-253 interferon gamma Homo sapiens 101-110 11438544-7 2001 Taken together, these results suggest that the following events lead to the activation of STAT1 upon IFN gamma stimulation: 1) PI3K and Akt are activated by the occupied receptor and Tyr-440 is phosphorylated by the activated JAKs; 2) STAT1 docks to Tyr-440; and 3) Tyr-701 is phosphorylated by the JAKs and Ser-727 is phosphorylated by a kinase downstream of Akt. Serine 308-311 interferon gamma Homo sapiens 101-110 11875767-1 2001 Pentoxifylline (PTX), a phosphodiesterase inhibitor, is known to downregulate tumor necrosis factor-alpha (TNF-alpha) secretion induced by lipopolysacchride (LPS) and gamma interferon (IFN-gamma). Pentoxifylline 0-14 interferon gamma Homo sapiens 167-194 11597034-7 2001 RESULTS: The magnitude of the gene expressions of IL-2, IFN-gamma, and IFN-gamma/IL-10 ratio were significantly higher in PGN than in NPGN. pgn 122-125 interferon gamma Homo sapiens 56-65 11597034-7 2001 RESULTS: The magnitude of the gene expressions of IL-2, IFN-gamma, and IFN-gamma/IL-10 ratio were significantly higher in PGN than in NPGN. pgn 122-125 interferon gamma Homo sapiens 71-80 11833850-2 2001 In previous work we have demonstrated that, after activation with recombinant human interferon-gamma and/or bacterial lipopolysaccharide, human macrophages infected with Leishmania infantum are able to produce nitric oxide and to express nitric oxide synthase. Nitric Oxide 210-222 interferon gamma Homo sapiens 84-100 11875767-1 2001 Pentoxifylline (PTX), a phosphodiesterase inhibitor, is known to downregulate tumor necrosis factor-alpha (TNF-alpha) secretion induced by lipopolysacchride (LPS) and gamma interferon (IFN-gamma). Pentoxifylline 16-19 interferon gamma Homo sapiens 167-194 11595074-7 2001 The pretreatment with interferon (IFN)-gamma markedly enhanced the effects of Fas Ag stimulation; IFN-gamma pretreatment and Fas Ag stimulation synergistically induced not only apoptosis but also IL-8 and MCP-1 secretion. ammonium ferrous sulfate 78-81 interferon gamma Homo sapiens 22-44 11595074-7 2001 The pretreatment with interferon (IFN)-gamma markedly enhanced the effects of Fas Ag stimulation; IFN-gamma pretreatment and Fas Ag stimulation synergistically induced not only apoptosis but also IL-8 and MCP-1 secretion. ammonium ferrous sulfate 78-81 interferon gamma Homo sapiens 98-107 11509600-5 2001 Functional impairment as measured by IFN-gamma release occurred earlier and at lower doses of exogenously added H2O2 than required to induce apoptosis. Hydrogen Peroxide 112-116 interferon gamma Homo sapiens 37-46 11536325-2 2001 It is well known that in response to lipopolysaccharide (LPS) and cytokines, such as IFN-gamma, glial cells are induced to synthesize large amount of nitric oxide (NO) (Bolanos et al., 1996; Nicoletti et al., 1998). Nitric Oxide 150-162 interferon gamma Homo sapiens 85-94 11697129-1 2001 Interferon-gamma stimulation of human macrophages causes the synthesis and release of neopterin and its reduced form 7,8-dihydroneopterin (7,8-NP). Neopterin 86-95 interferon gamma Homo sapiens 0-16 11697129-1 2001 Interferon-gamma stimulation of human macrophages causes the synthesis and release of neopterin and its reduced form 7,8-dihydroneopterin (7,8-NP). 7,8-dihydroneopterin 117-137 interferon gamma Homo sapiens 0-16 11697129-1 2001 Interferon-gamma stimulation of human macrophages causes the synthesis and release of neopterin and its reduced form 7,8-dihydroneopterin (7,8-NP). 7,8-dihydroneopterin 139-145 interferon gamma Homo sapiens 0-16 11536325-5 2001 Our study shows increased JAK2 and STAT1 alpha/beta tyrosine phosphorylation in primary astroglial cell culture after treatment with IFN-gamma and LPS. Tyrosine 52-60 interferon gamma Homo sapiens 133-142 11536325-7 2001 Inhibition experiments showed that JAK2 and STAT1 alpha/beta tyrosine phosphorylation were necessary for IFN gamma-mediated iNOS induction in astroglial cells. Tyrosine 61-69 interferon gamma Homo sapiens 105-114 11469797-3 2001 As we previously reported, parental IM4/V/IV cells express high levels of GnT-IVa and -V and produce hIFN-gamma having primarily tetraantennary sugar chains. Sugars 144-149 interferon gamma Homo sapiens 101-111 11556541-6 2001 In view of these results, the increased expression of cathepsins L and B after IFN-gamma stimulation in muscle cultures and its inhibition using fludarabine, a STAT1 blocker, further support our previous studies and suggest that the increased expression of cathepsins detected in perifascicular muscle fibers in DM is mediated by IFN-gamma/STAT1 and contributes to their atrophy. fludarabine 145-156 interferon gamma Homo sapiens 330-339 11516202-5 2001 RESULTS: AAT-DCs induced specific IFN-gamma by T lymphocytes of two patients (rectal and gastric cancer), whereas in another two patients (rectal and gastric cancer) this response was depressed with a similar tumor-specific pattern and in one patient (rectal cancer) there was no response. o-Aminoazotoluene 9-12 interferon gamma Homo sapiens 34-43 11500375-5 2001 In whole cells, Hsp70-FANCC binding and protection from IFN-gamma/TNF-alpha-induced cytotoxicity were blocked by alanine mutations located in a conserved motif within the Hsp70-interacting domain of FANCC. Alanine 113-120 interferon gamma Homo sapiens 56-65 11509336-2 2001 In the current study, we evaluated the hypothesis that a number of inflammatory factors, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, and interferon (IFN)-gamma, modulate this process by induction of prostaglandin (PG) E(2) and nitric oxide (NO) production and that these secondary mediators function in an autocrine or paracrine manner to modulate contraction. Prostaglandins E 225-245 interferon gamma Homo sapiens 163-185 11508428-10 2001 In 6 of the 8 patients who improved, interferon-gamma production decreased after oral CII therapy, correlating with clinical improvement, while 6 patients had increases in levels of transforming growth factor beta3. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 86-89 interferon gamma Homo sapiens 37-53 11603002-4 2001 However, IFN-gamma attenuated the anti-tumor effect of 5-FU at the concentrations of 0.1-10 IU/ml. Fluorouracil 55-59 interferon gamma Homo sapiens 9-18 11603002-6 2001 As low as 0.1 IU/ml of IFN-gamma attenuated the anti-tumor effect of 5-FU in another experimental system where HCT-15 cells were exposed to 0.1 IU/ml of IFN-gamma before and during the treatment with 5-FU. Fluorouracil 69-73 interferon gamma Homo sapiens 23-32 11603002-6 2001 As low as 0.1 IU/ml of IFN-gamma attenuated the anti-tumor effect of 5-FU in another experimental system where HCT-15 cells were exposed to 0.1 IU/ml of IFN-gamma before and during the treatment with 5-FU. Fluorouracil 69-73 interferon gamma Homo sapiens 153-162 11603002-6 2001 As low as 0.1 IU/ml of IFN-gamma attenuated the anti-tumor effect of 5-FU in another experimental system where HCT-15 cells were exposed to 0.1 IU/ml of IFN-gamma before and during the treatment with 5-FU. Fluorouracil 200-204 interferon gamma Homo sapiens 23-32 11591123-8 2001 Dexamethasone inhibited the upregulation of Fas and FasL by IFN-gamma and the induction of SGEC apoptosis and detachment by anti-Fas mAb or IFN-gamma. Dexamethasone 0-13 interferon gamma Homo sapiens 60-69 11591123-8 2001 Dexamethasone inhibited the upregulation of Fas and FasL by IFN-gamma and the induction of SGEC apoptosis and detachment by anti-Fas mAb or IFN-gamma. Dexamethasone 0-13 interferon gamma Homo sapiens 140-149 11591123-9 2001 Our findings indicate the injurious role of IFN-gamma for the salivary epithelia of SS patients through the induction of Fas-mediated apoptosis and anoikia. ammonium ferrous sulfate 121-124 interferon gamma Homo sapiens 44-53 12567742-2 2001 METHOD: According to the nucleotide sequence of ifn-gamma gene, a pair of oligonucleotides was designed as primer whose two end contained nucleotide sequence of EcoR V and Not I restriction endonuclease respectively. Oligonucleotides 74-90 interferon gamma Homo sapiens 48-57 11554612-4 2001 The results indicate that Saquinavir is able to increase proliferation and interferon-gamma release in PHA-stimulated NAMNC, and telomerase activity either in non-stimulated and in PHA or antibody-activated cells. Saquinavir 26-36 interferon gamma Homo sapiens 75-91 11507170-5 2001 In the absence of interferon-gamma only tryptophan and threonine were significantly lowered; in the presence of interferon-gamma (known to stimulate indoleamine 2,3-dioxygenase) tryptophan but not threonine depletion was much greater. Tryptophan 178-188 interferon gamma Homo sapiens 112-128 11513821-4 2001 RESULTS: We found that lithium caused an increase in interleukin-4 and interleukin-10 levels, traditionally classified as T-helper lymphocyte type-2 cytokines, and a decrease in interleukin-2 and interferon-gamma levels, traditionally classified as T-helper lymphocyte type-1 (TH-1) cytokines. Lithium 23-30 interferon gamma Homo sapiens 196-212 11529908-5 2001 By contrast, addition of exogenous rIL-6 impaired IFN-gamma production by rIL-12-prompted T cells. ril-12 74-80 interferon gamma Homo sapiens 50-59 11469797-4 2001 The branching of sugar chains on hIFN-gamma was suppressed in the beta 1,4-GalT-enhanced clones to a level corresponding to the intracellular activity of beta 1,4-GalT relative to GnTs. Sugars 17-22 interferon gamma Homo sapiens 33-43 11500833-6 2001 We show that: (1) the calcium response is identical following weak and strong TCR stimulation; (2) mitogen-activated protein kinase(MAPK) activation is a gradual phenomenon depending upon the strength of TCR activation; (3) a calcium response, even weak, triggers IL-4 expression; (4) IFN-gamma synthesis requires not only a calcium response but also MAPK activation. Calcium 22-29 interferon gamma Homo sapiens 285-294 11500833-6 2001 We show that: (1) the calcium response is identical following weak and strong TCR stimulation; (2) mitogen-activated protein kinase(MAPK) activation is a gradual phenomenon depending upon the strength of TCR activation; (3) a calcium response, even weak, triggers IL-4 expression; (4) IFN-gamma synthesis requires not only a calcium response but also MAPK activation. Calcium 226-233 interferon gamma Homo sapiens 285-294 11495701-11 2001 DCs cultured with the poorly immunogenic RPMI 8226 expressing CD40L upregulated T-lymphocyte release of IFN-gamma and other Th1 cytokines (interleukin-2, tumor necrosis factor-alpha). rpmi 41-45 interferon gamma Homo sapiens 104-113 11500833-6 2001 We show that: (1) the calcium response is identical following weak and strong TCR stimulation; (2) mitogen-activated protein kinase(MAPK) activation is a gradual phenomenon depending upon the strength of TCR activation; (3) a calcium response, even weak, triggers IL-4 expression; (4) IFN-gamma synthesis requires not only a calcium response but also MAPK activation. Calcium 226-233 interferon gamma Homo sapiens 285-294 11476770-11 2001 Tyrosine phosphorylation of STAT 1 in capacitated sperm was enhanced by IFN-alpha and IFN-gamma, and that of STAT 4 was enhanced by IL-12. Tyrosine 0-8 interferon gamma Homo sapiens 86-95 11454803-10 2001 Furthermore, the caspase inhibitor z-vad-fmk completely prevented IFN-gamma mediated apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 35-44 interferon gamma Homo sapiens 66-75 11434990-12 2001 At the lower DON concentration (200 ng/ml), IL-2 levels were elevated 17-25-fold with a concomitant mild elevation in IFN-gamma. deoxynivalenol 13-16 interferon gamma Homo sapiens 118-127 11529938-4 2001 In the present study, we investigated the effect of sulphasalazine and two related compounds - sulphapyridine and 5-aminosalicylic acid - on M phi activation induced by bacterial lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma). Sulfasalazine 52-66 interferon gamma Homo sapiens 208-224 11694024-3 2001 In addition, an exogenous NO donor, sodium nitroprusside (SNP) significantly prevents cell death induced by IFN-gamma alone or IFN-gamma plus LPS (IFN-gamma/LPS) in a dose-dependent manner over 25 microM. Nitroprusside 36-56 interferon gamma Homo sapiens 108-117 11694024-3 2001 In addition, an exogenous NO donor, sodium nitroprusside (SNP) significantly prevents cell death induced by IFN-gamma alone or IFN-gamma plus LPS (IFN-gamma/LPS) in a dose-dependent manner over 25 microM. Nitroprusside 36-56 interferon gamma Homo sapiens 127-136 11529938-4 2001 In the present study, we investigated the effect of sulphasalazine and two related compounds - sulphapyridine and 5-aminosalicylic acid - on M phi activation induced by bacterial lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma). Sulfapyridine 95-109 interferon gamma Homo sapiens 208-224 11529938-4 2001 In the present study, we investigated the effect of sulphasalazine and two related compounds - sulphapyridine and 5-aminosalicylic acid - on M phi activation induced by bacterial lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma). Mesalamine 114-135 interferon gamma Homo sapiens 208-224 11529938-5 2001 In J774 M phi stimulated with LPS (10 microg/ml) and IFN-gamma (100 U/ml), sulphasalazine (50-500 microM) suppressed nitric oxide (NO) production in a concentration-dependent manner. Sulfasalazine 75-89 interferon gamma Homo sapiens 53-62 11529938-5 2001 In J774 M phi stimulated with LPS (10 microg/ml) and IFN-gamma (100 U/ml), sulphasalazine (50-500 microM) suppressed nitric oxide (NO) production in a concentration-dependent manner. Nitric Oxide 117-129 interferon gamma Homo sapiens 53-62 11529938-9 2001 Although the combination of LPS and IFN-gamma induced a rapid expression of the active forms of p38 and p42/44 mitogen-activated protein kinases and c-Jun terminal kinase, sulphasalazine failed to interfere with the activation of any of these kinases. Sulfasalazine 172-186 interferon gamma Homo sapiens 36-45 11529938-10 2001 Finally, sulphasalazine suppressed the IFN-gamma-induced expression of major histocompatibility complex class II. Sulfasalazine 9-23 interferon gamma Homo sapiens 39-48 11477316-0 2001 Quantitation of immunosuppression by tacrolimus using flow cytometric analysis of interleukin-2 and interferon-gamma inhibition in CD8(-) and CD8(+) peripheral blood T cells. Tacrolimus 37-47 interferon gamma Homo sapiens 100-116 11555319-13 2001 After CsA treatment there was a significant reduction in interferon-gamma (IFN-gamma), IL-2, IL-4, IL-13, and HLA-DR-positive CD3(+) cells. Cyclosporine 6-9 interferon gamma Homo sapiens 57-73 11555319-13 2001 After CsA treatment there was a significant reduction in interferon-gamma (IFN-gamma), IL-2, IL-4, IL-13, and HLA-DR-positive CD3(+) cells. Cyclosporine 6-9 interferon gamma Homo sapiens 75-84 11477316-1 2001 The authors have determined the frequency of intracellular interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) synthesis by T-cell subsets in whole blood (WB) and isolated lymphocytes in 16 transplant recipients treated with tacrolimus and 10 control patients who were not transplant recipients. Tacrolimus 227-237 interferon gamma Homo sapiens 84-100 11477316-1 2001 The authors have determined the frequency of intracellular interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) synthesis by T-cell subsets in whole blood (WB) and isolated lymphocytes in 16 transplant recipients treated with tacrolimus and 10 control patients who were not transplant recipients. Tacrolimus 227-237 interferon gamma Homo sapiens 102-111 11410875-2 2001 Among the 2 hepatitis B virus (HBV)-associated hepatoma cell lines, SNU-354 and SNU-368, IFN-gamma induced cell death and increased caspase-3 activity in SNU-368 but not in SNU-354. 4-(1H-Pyrrol-1-yl)aniline 68-71 interferon gamma Homo sapiens 89-98 11490364-7 2001 RESULTS: Morphine treatment of PBMCs decreases IL-2 and IFN gamma and increases IL-4 and IL-5 as a function of morphine concentration. Morphine 9-17 interferon gamma Homo sapiens 56-65 11473738-4 2001 Consistent with this view is the recent report that cytokines, such as tumor necrosis factor-alpha, can influence the expression of the scavenger receptor, whereas interferon-gamma can inhibit adenosine triphosphate-binding cassette transporter-1, the main effector of cholesterol efflux in the peripheral cell. Cholesterol 269-280 interferon gamma Homo sapiens 164-180 11490364-8 2001 Morphine treatment in wild type splenocytes inhibited IFN gamma and stimulated IL-4 protein synthesis. Morphine 0-8 interferon gamma Homo sapiens 54-63 11410875-2 2001 Among the 2 hepatitis B virus (HBV)-associated hepatoma cell lines, SNU-354 and SNU-368, IFN-gamma induced cell death and increased caspase-3 activity in SNU-368 but not in SNU-354. 4-(1H-Pyrrol-1-yl)aniline 80-83 interferon gamma Homo sapiens 89-98 11410875-2 2001 Among the 2 hepatitis B virus (HBV)-associated hepatoma cell lines, SNU-354 and SNU-368, IFN-gamma induced cell death and increased caspase-3 activity in SNU-368 but not in SNU-354. 4-(1H-Pyrrol-1-yl)aniline 80-83 interferon gamma Homo sapiens 89-98 11410875-9 2001 From these findings, we speculated that TRAIL up-regulation and the subsequent TRAIL-mediated apoptosis serve as a mechanism of IFN-gamma-induced cell death in SNU-368. 4-(1H-Pyrrol-1-yl)aniline 160-163 interferon gamma Homo sapiens 128-137 11410875-10 2001 To confirm this hypothesis, we demonstrated that soluble DR4-Fc fusion protein, a TRAIL pathway inhibitor, inhibited IFN-gamma-induced cell death in SNU-368. 4-(1H-Pyrrol-1-yl)aniline 149-152 interferon gamma Homo sapiens 117-126 11468004-12 2001 In addition, Ac2-26 and dexamethasone inhibited Der p-induced IL-5 release and PPD-induced IFN-gamma release in a concentration-dependent fashion. annexin A1 peptide (2-26) 13-19 interferon gamma Homo sapiens 91-100 11435314-0 2001 Improved superoxide-generating ability by interferon gamma due to splicing pattern change of transcripts in neutrophils from patients with a splice site mutation in CYBB gene. Superoxides 9-19 interferon gamma Homo sapiens 42-58 11435314-2 2001 Based on an increase of neutrophil superoxide-generating ability in response to interferon gamma (IFN-gamma) in a single patient with CGD, multicentered group studies demonstrated a beneficial effect of prophylactic IFN-gamma. Superoxides 35-45 interferon gamma Homo sapiens 80-107 11435314-2 2001 Based on an increase of neutrophil superoxide-generating ability in response to interferon gamma (IFN-gamma) in a single patient with CGD, multicentered group studies demonstrated a beneficial effect of prophylactic IFN-gamma. Superoxides 35-45 interferon gamma Homo sapiens 98-107 11435314-4 2001 The present report offers an additional kindred in whom an IFN-gamma-dependent increase in neutrophil superoxide production was observed in 3 affected patients. Superoxides 102-112 interferon gamma Homo sapiens 59-68 11418482-4 2001 It was demonstrated that Thal/IMiDs do not induce T-cell proliferation alone but act as costimulators to trigger proliferation of anti-CD3-stimulated T cells from patients with MM, accompanied by an increase in interferon-gamma and IL-2 secretion. Thalidomide 25-29 interferon gamma Homo sapiens 211-227 11418482-4 2001 It was demonstrated that Thal/IMiDs do not induce T-cell proliferation alone but act as costimulators to trigger proliferation of anti-CD3-stimulated T cells from patients with MM, accompanied by an increase in interferon-gamma and IL-2 secretion. imids 30-35 interferon gamma Homo sapiens 211-227 11435314-8 2001 The changes in the splicing pattern of the transcripts and the prolonged effect on superoxide-generating ability of patient neutrophils indicate that IFN-gamma induced a partial correction of the abnormal splicing of CYBB gene transcripts in myeloid progenitor cells. Superoxides 83-93 interferon gamma Homo sapiens 150-159 11468004-12 2001 In addition, Ac2-26 and dexamethasone inhibited Der p-induced IL-5 release and PPD-induced IFN-gamma release in a concentration-dependent fashion. Dexamethasone 24-37 interferon gamma Homo sapiens 91-100 11453675-9 2001 Loading with carbon further aggravated the effect of IFN-gamma. Carbon 13-19 interferon gamma Homo sapiens 53-62 11416037-4 2001 IFNgamma antagonizes cAMP-mediated PRL protein and messenger RNA expression in primary ES cell cultures through inhibition of decidual PRL promoter activity. Cyclic AMP 21-25 interferon gamma Homo sapiens 0-8 11507674-7 2001 This observation confirmed that selective cholesterol ester uptake from HDL was inhibited by IFN-gamma. Cholesterol Esters 42-59 interferon gamma Homo sapiens 93-102 11431425-3 2001 EdCIITA extinguished the inducible and constitutive expression of MHC II genes in epithelial cells treated with IFN-gamma and B lymphoblastoid cells respectively. edciita 0-7 interferon gamma Homo sapiens 112-121 11418634-5 2001 Transient transfection of AD10 cells with pGL-3-FasP demonstrated that the IFN-gamma-dependent NO generation increases the trans-activation of the Fas promoter, and this increase was blocked by the NOS inhibitor (N(G)-monomethyl-L-arginine), but could be restored by the addition of the NO donor S-nitroso-N-acetylpenicillamine. omega-N-Methylarginine 213-239 interferon gamma Homo sapiens 75-84 11506390-5 2001 RESULTS: Both N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine, and 1-O-Alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine induced superoxide release in umbilical cord eosinophils, while no response was observed with lipopolysaccharide, interleukin-4 and/or interferon-gamma. N-Formylmethionine Leucyl-Phenylalanine 14-59 interferon gamma Homo sapiens 251-267 11506390-5 2001 RESULTS: Both N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine, and 1-O-Alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine induced superoxide release in umbilical cord eosinophils, while no response was observed with lipopolysaccharide, interleukin-4 and/or interferon-gamma. platelet activating factor phosphatidate 65-115 interferon gamma Homo sapiens 251-267 11408917-5 2001 Treatment of ACHN cells with CDDP, VLB, IFN-alpha, or IFN-gamma did not activate caspase-3, but its activity was increased 7.2-fold (p = 0.0001) with ADR and 2.8-fold (p = 0.0385) with 5-FU in comparison with control. Fluorouracil 185-189 interferon gamma Homo sapiens 54-63 11418634-5 2001 Transient transfection of AD10 cells with pGL-3-FasP demonstrated that the IFN-gamma-dependent NO generation increases the trans-activation of the Fas promoter, and this increase was blocked by the NOS inhibitor (N(G)-monomethyl-L-arginine), but could be restored by the addition of the NO donor S-nitroso-N-acetylpenicillamine. S-Nitroso-N-Acetylpenicillamine 296-327 interferon gamma Homo sapiens 75-84 11421619-15 2001 IFNgamma acts on macrophages to release large amounts of nitric oxide (NO). Nitric Oxide 57-69 interferon gamma Homo sapiens 0-8 11410796-2 2001 MKN-1 gastric cancer cells were treated with the IC50 of 5-FU in the presence of interferon-gamma (IFN-gamma). Fluorouracil 57-61 interferon gamma Homo sapiens 81-97 11410796-2 2001 MKN-1 gastric cancer cells were treated with the IC50 of 5-FU in the presence of interferon-gamma (IFN-gamma). Fluorouracil 57-61 interferon gamma Homo sapiens 99-108 11410796-5 2001 After 5-FU treatment in the presence of IFN-gamma, NO and TNF-alpha were produced and anti-tumor activity was enhanced. Fluorouracil 6-10 interferon gamma Homo sapiens 40-49 12090349-3 2001 We hypothesized that treatments with liposome encapsulated ATP or NAD+ would protect human endothelial cells exposed to endotoxin (LPS) and interferon-gamma (IFN-gamma) from energy failure. Adenosine Triphosphate 59-62 interferon gamma Homo sapiens 140-156 12090349-3 2001 We hypothesized that treatments with liposome encapsulated ATP or NAD+ would protect human endothelial cells exposed to endotoxin (LPS) and interferon-gamma (IFN-gamma) from energy failure. Adenosine Triphosphate 59-62 interferon gamma Homo sapiens 158-167 12090349-3 2001 We hypothesized that treatments with liposome encapsulated ATP or NAD+ would protect human endothelial cells exposed to endotoxin (LPS) and interferon-gamma (IFN-gamma) from energy failure. NAD 66-70 interferon gamma Homo sapiens 140-156 12090349-3 2001 We hypothesized that treatments with liposome encapsulated ATP or NAD+ would protect human endothelial cells exposed to endotoxin (LPS) and interferon-gamma (IFN-gamma) from energy failure. NAD 66-70 interferon gamma Homo sapiens 158-167 11509144-4 2001 RESULTS: The percentage of IFN-gamma-producing T cells in CD4+ T cells was higher in patients with CSH (7.2%-26.3%) than in normal controls (2.2%-11.9%) (P<0.01). csh 99-102 interferon gamma Homo sapiens 27-36 11426981-7 2001 Moreover, coincubation of OVCAR-3 and HOC-7 with the specific iNOS inhibitor aminoguanidine suppressed apoptosis induced by IFN-gamma, IL-1beta, and TNF-alpha. pimagedine 77-91 interferon gamma Homo sapiens 124-133 11496824-4 2001 Using human PBMC culture, it was demonstrated that histamine was a potent inducer of IL-18, IFN-gamma in human PBMC. Histamine 51-60 interferon gamma Homo sapiens 92-101 11464104-0 2001 Dithranol and dimethylfumarate suppress the interferon-gamma-induced up-regulation of cytokeratin 17 as a putative psoriasis autoantigen in vitro. Anthralin 0-9 interferon gamma Homo sapiens 44-60 11464104-0 2001 Dithranol and dimethylfumarate suppress the interferon-gamma-induced up-regulation of cytokeratin 17 as a putative psoriasis autoantigen in vitro. Dimethyl Fumarate 14-30 interferon gamma Homo sapiens 44-60 11464104-5 2001 Preincubation with a subcytotoxic and antiproliferative dithranol concentration as low as 0.3 microM for 2 h prior to the IFN-gamma exposure resulted in a K17 expression that was significantly lower than the IFN-gamma-induced K17 expression reference level. Anthralin 56-65 interferon gamma Homo sapiens 122-131 11464104-5 2001 Preincubation with a subcytotoxic and antiproliferative dithranol concentration as low as 0.3 microM for 2 h prior to the IFN-gamma exposure resulted in a K17 expression that was significantly lower than the IFN-gamma-induced K17 expression reference level. Anthralin 56-65 interferon gamma Homo sapiens 208-217 11464104-6 2001 The IFN-gamma-induced K17 expression was also significantly lowered by coincubation with a subcytotoxic and nonantiproliferative concentration of 3 microM dimethylfumarate. Dimethyl Fumarate 155-171 interferon gamma Homo sapiens 4-13 11501888-9 2001 These T cells secrete IFN-gamma in the skin, which upregulates Fas on keratinocytes and renders them susceptible to apoptosis. ammonium ferrous sulfate 63-66 interferon gamma Homo sapiens 22-31 11381145-1 2001 The equilibrium dissociation of recombinant human IFN-gamma was monitored as a function of pressure and sucrose concentration. Sucrose 104-111 interferon gamma Homo sapiens 50-59 11381145-4 2001 The first-order aggregation rate of recombinant human IFN-gamma in 0.45 M guanidine hydrochloride was studied as a function of sucrose concentration and pressure. Guanidine 74-97 interferon gamma Homo sapiens 54-63 11381145-4 2001 The first-order aggregation rate of recombinant human IFN-gamma in 0.45 M guanidine hydrochloride was studied as a function of sucrose concentration and pressure. Sucrose 127-134 interferon gamma Homo sapiens 54-63 11410369-2 2001 In airway parasympathetic neurons, M(2) receptor expression is decreased by viral infections and by interferon-gamma, increasing actylcholine release. actylcholine 129-141 interferon gamma Homo sapiens 100-116 11407316-6 2001 In a comparative study with steroids (alclometasone dipropionate and betamethason valerate) in anti-CD3/CD2 system, tacrolimus and both steroids inhibited Th1 cytokines (IL-2, IFN-gamma), Th2 cytokines (IL-4, IL-5) and IL-3, GM-CSF (produced by both Th1 and Th2). betamethason valerate 69-90 interferon gamma Homo sapiens 176-185 11513771-8 2001 CONCLUSIONS: Our data show that LH is associated with a higher production of inflammatory cytokines (IFN-gamma and IL-6) compared with BH, likely induced by the presence of the polypropylene prostheses. Luteinizing Hormone 32-34 interferon gamma Homo sapiens 101-110 11513771-8 2001 CONCLUSIONS: Our data show that LH is associated with a higher production of inflammatory cytokines (IFN-gamma and IL-6) compared with BH, likely induced by the presence of the polypropylene prostheses. Polypropylenes 177-190 interferon gamma Homo sapiens 101-110 11472402-6 2001 Melatonin suppressed the release of TNF-alpha by LPS or IFN-gamma activated macrophages but failed to inhibit nitric oxide (NO) release. Melatonin 0-9 interferon gamma Homo sapiens 56-65 11407316-6 2001 In a comparative study with steroids (alclometasone dipropionate and betamethason valerate) in anti-CD3/CD2 system, tacrolimus and both steroids inhibited Th1 cytokines (IL-2, IFN-gamma), Th2 cytokines (IL-4, IL-5) and IL-3, GM-CSF (produced by both Th1 and Th2). Tacrolimus 116-126 interferon gamma Homo sapiens 176-185 11407316-6 2001 In a comparative study with steroids (alclometasone dipropionate and betamethason valerate) in anti-CD3/CD2 system, tacrolimus and both steroids inhibited Th1 cytokines (IL-2, IFN-gamma), Th2 cytokines (IL-4, IL-5) and IL-3, GM-CSF (produced by both Th1 and Th2). Steroids 136-144 interferon gamma Homo sapiens 176-185 11440631-4 2001 We show in this report that human IFN-gamma (HuIFN-gamma) contains a second NLS at an upstream site, as determined in standard import assays using digitonin-permeabilized HeLa cells. Digitonin 147-156 interferon gamma Homo sapiens 34-43 11413232-4 2001 We found that tumor necrosis factor-alpha and interferon-gamma exert synergistic inhibitory action on Schwann cell viability via the production of nitric oxide (NO) and ceramide (cer). Nitric Oxide 147-159 interferon gamma Homo sapiens 46-62 11413232-4 2001 We found that tumor necrosis factor-alpha and interferon-gamma exert synergistic inhibitory action on Schwann cell viability via the production of nitric oxide (NO) and ceramide (cer). Ceramides 169-177 interferon gamma Homo sapiens 46-62 11413232-4 2001 We found that tumor necrosis factor-alpha and interferon-gamma exert synergistic inhibitory action on Schwann cell viability via the production of nitric oxide (NO) and ceramide (cer). Ceramides 169-172 interferon gamma Homo sapiens 46-62 11376118-6 2001 The overexpression of inducible NOS by lipopolysaccharide + interferon-gamma further increased NO and cGMP levels, and the majority of de novo produced cGMP was rapidly released. Cyclic GMP 102-106 interferon gamma Homo sapiens 60-76 11475438-2 2001 The IFN-gamma (IFNG) contains a multiallelic dinucleotide repeat in intron 1. Dinucleoside Phosphates 45-57 interferon gamma Homo sapiens 4-13 11475438-2 2001 The IFN-gamma (IFNG) contains a multiallelic dinucleotide repeat in intron 1. Dinucleoside Phosphates 45-57 interferon gamma Homo sapiens 15-19 11290380-3 2001 Upon stimulation with interferon-gamma and lipopolysaccharides, the microglial cells adopted an activated phenotype and secreted tumor necrosis factor-alpha (TNF-alpha), prostaglandin E(2) and nitric oxide (NO). Prostaglandins E 170-185 interferon gamma Homo sapiens 22-38 11290380-3 2001 Upon stimulation with interferon-gamma and lipopolysaccharides, the microglial cells adopted an activated phenotype and secreted tumor necrosis factor-alpha (TNF-alpha), prostaglandin E(2) and nitric oxide (NO). Nitric Oxide 193-205 interferon gamma Homo sapiens 22-38 11433779-4 2001 On the other hand, the other gallic acid derivatives suppressed the secretion of both IL-4 and IFN-gamma. Gallic Acid 29-40 interferon gamma Homo sapiens 95-104 11342657-0 2001 Antioxidants inhibit indoleamine 2,3-dioxygenase in IFN-gamma-activated human macrophages: posttranslational regulation by pyrrolidine dithiocarbamate. pyrrolidine dithiocarbamic acid 123-150 interferon gamma Homo sapiens 52-61 11342657-3 2001 Here we show that IFN-gamma treatment of human monocyte-derived macrophages (hMDMs) increased the proportion of oxidized glutathione. Glutathione 121-132 interferon gamma Homo sapiens 18-27 11341797-7 2001 High levels of the human Th1 cytokines TNF-alpha (20-350 pg/ml) and IFN-gamma (200-3800 pg/ml) were detected only in cultures containing PAEC, with levels peaking on Day 4. paec 137-141 interferon gamma Homo sapiens 68-77 11342638-7 2001 The IFN-gamma response can be blocked by 2",5"-oligoadenylate-linked antisense chimeras against PKR mRNA. 2',5'-oligoadenylate 41-61 interferon gamma Homo sapiens 4-13 11257311-2 2001 Treatment of RAW264.7 macrophages with interferon-gamma (IFN- gamma) caused a significant increase in tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) production. Nitric Oxide 146-158 interferon gamma Homo sapiens 39-67 11342672-7 2001 Two cytokines, IFN-gamma and IL-6, were found to be responsible for the function of CD8(+) TS: In fact, counteraction of CD8(+) Ts suppression activity was obtained by blocking IFN-gamma with a specific Ab or by inhibiting CD8(+) Ts-mediated IL-6 secretion by an antisense oligonucleotide. Oligonucleotides 273-288 interferon gamma Homo sapiens 177-186 11342657-7 2001 Also, incubation of IFN-gamma-activated hMDM with delta-[(14)C]-aminolevulinic acid resulted in the incorporation of label into immunoprecipitated IDO, a process inhibited by PDTC and SA. delta-[(14)c]-aminolevulinic acid 50-83 interferon gamma Homo sapiens 20-29 11342657-9 2001 Together these results establish a requirement for de novo heme synthesis for IDO activity in IFN-gamma-activated hMDM. Heme 59-63 interferon gamma Homo sapiens 94-103 11342663-0 2001 ATP mediates calcium signaling between astrocytes and microglial cells: modulation by IFN-gamma. Adenosine Triphosphate 0-3 interferon gamma Homo sapiens 86-95 11342663-0 2001 ATP mediates calcium signaling between astrocytes and microglial cells: modulation by IFN-gamma. Calcium 13-20 interferon gamma Homo sapiens 86-95 11342663-6 2001 IFN-gamma increased ATP release and potentiated the P2X(7)-mediated cytolytic effect. Adenosine Triphosphate 20-23 interferon gamma Homo sapiens 0-9 11342672-7 2001 Two cytokines, IFN-gamma and IL-6, were found to be responsible for the function of CD8(+) TS: In fact, counteraction of CD8(+) Ts suppression activity was obtained by blocking IFN-gamma with a specific Ab or by inhibiting CD8(+) Ts-mediated IL-6 secretion by an antisense oligonucleotide. Oligonucleotides 273-288 interferon gamma Homo sapiens 15-24 11302872-3 2001 After stimulation with phorbol ester/ionomycin, expression of the intracellular cytokines IFNgamma, IL2, IL4, and IL10 was determined in CD3+, CD3+CD8+ and CD3+CD8- T cells by flow cytometry. Phorbol Esters 23-36 interferon gamma Homo sapiens 90-98 11392499-0 2001 3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma. 3-Hydroxyanthranilic Acid 0-25 interferon gamma Homo sapiens 113-129 11392499-0 2001 3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma. Tryptophan 30-42 interferon gamma Homo sapiens 113-129 11392499-7 2001 Interferon-gamma (IFN-gamma), an inducer of IDO, potently induced apoptosis in THP-1 cells, but not in U937 cells, in the presence of ferrous or manganese ions. ammonium ferrous sulfate 134-141 interferon gamma Homo sapiens 0-16 11392499-7 2001 Interferon-gamma (IFN-gamma), an inducer of IDO, potently induced apoptosis in THP-1 cells, but not in U937 cells, in the presence of ferrous or manganese ions. ammonium ferrous sulfate 134-141 interferon gamma Homo sapiens 18-27 11392499-7 2001 Interferon-gamma (IFN-gamma), an inducer of IDO, potently induced apoptosis in THP-1 cells, but not in U937 cells, in the presence of ferrous or manganese ions. Manganese 145-154 interferon gamma Homo sapiens 0-16 11392499-7 2001 Interferon-gamma (IFN-gamma), an inducer of IDO, potently induced apoptosis in THP-1 cells, but not in U937 cells, in the presence of ferrous or manganese ions. Manganese 145-154 interferon gamma Homo sapiens 18-27 11397960-4 2001 METHODS AND RESULTS: Simvastatin pretreatment inhibited MVEC HILA-DR induction by IFN-gamma, as detected by flow cytometry. Simvastatin 21-32 interferon gamma Homo sapiens 82-91 11397960-7 2001 Although signal transducer and activator of transcription (STAT)-1 is a critical CIITA gene transactivator, immunofluorescence studies, Western blotting, and electrophoretic mobility shift assays demonstrated that IFN-gamma-induced STAT-1 phosphorylation, nuclear translocation, and DNA binding are not affected by simvastatin. Simvastatin 315-326 interferon gamma Homo sapiens 214-223 11397960-8 2001 However, simvastatin inhibited IFN-gamma-induced transactivation of a CIITA promoter IV reporter construct, indicating the involvement of this promoter in the inhibitory effect of simvastatin. Simvastatin 9-20 interferon gamma Homo sapiens 31-40 11397960-8 2001 However, simvastatin inhibited IFN-gamma-induced transactivation of a CIITA promoter IV reporter construct, indicating the involvement of this promoter in the inhibitory effect of simvastatin. Simvastatin 180-191 interferon gamma Homo sapiens 31-40 11397960-9 2001 CONCLUSIONS: Simvastatin pretreatment inhibits CIITA and consequent HLA-DR induction by IFN-gamma in MVECs through interference with protein prenylation. Simvastatin 13-24 interferon gamma Homo sapiens 88-97 11257311-4 2001 Human ANP(99-126) and a specific p38 MAP kinase inhibitor SB203580 inhibited the IFN-gamma-induced TNF-alpha production in a dose-dependent manner without affecting NO production. SB 203580 58-66 interferon gamma Homo sapiens 81-90 11422207-0 2001 Regulation of LPS induced IL-12 production by IFN-gamma and IL-4 through intracellular glutathione status in human alveolar macrophages. Glutathione 87-98 interferon gamma Homo sapiens 46-55 11376874-8 2001 Retinoic acid elicited synergistic effects on the CNP secretion rate from HL-60 cells when administered with lipopolysaccharide, interferon-gamma, interleukin-1beta, tumor necrosis factor-alpha, or phorbol ester. Tretinoin 0-13 interferon gamma Homo sapiens 129-145 11313309-11 2001 CONCLUSIONS: IFN-gamma inhibition of Na+,K+-ATPase activity acutely causes increases in intracellular Na(i) concentration and cell volume, which are distinct signaling events that ultimately result in a leaky and dysfunctional epithelium associated with chronic inflammation. Sodium Iodide 102-107 interferon gamma Homo sapiens 13-22 11292745-9 2001 These data demonstrated a multifaceted immune response to SLA in human leishmaniasis involving Th1 CD4(+) T lymphocytes (IFN-gamma(+) and IL-10(-)/IL-4(-)), Tc1 CD8(+) T cells (IFN-gamma(+), and IL-10(-)/IL-4(-)), and a high frequency of TNF-alpha-producing lymphocytes. (S)-lipoic acid 58-61 interferon gamma Homo sapiens 121-130 11292745-9 2001 These data demonstrated a multifaceted immune response to SLA in human leishmaniasis involving Th1 CD4(+) T lymphocytes (IFN-gamma(+) and IL-10(-)/IL-4(-)), Tc1 CD8(+) T cells (IFN-gamma(+), and IL-10(-)/IL-4(-)), and a high frequency of TNF-alpha-producing lymphocytes. (S)-lipoic acid 58-61 interferon gamma Homo sapiens 177-186 11329466-1 2001 The ability of the 45-kDa serine-rich Mycobacterium leprae antigen to stimulate peripheral blood mononuclear cell (PBMC) proliferation and gamma interferon (IFN-gamma) production was measured in leprosy patients, household contacts, and healthy controls from areas of endemicity in Mexico. Serine 26-32 interferon gamma Homo sapiens 139-166 11422207-3 2001 We examined whether IFN-gamma and IL-4 affect the balance between intracellular reduced glutathione (GSH) and oxidized (GSSG) glutathione, as this may affect IL-12 production in human alveolar macrophages (AM). Glutathione 88-99 interferon gamma Homo sapiens 20-29 11422207-3 2001 We examined whether IFN-gamma and IL-4 affect the balance between intracellular reduced glutathione (GSH) and oxidized (GSSG) glutathione, as this may affect IL-12 production in human alveolar macrophages (AM). Glutathione 101-104 interferon gamma Homo sapiens 20-29 11313389-3 2001 Thus, although pamidronate induced cell clustering, proliferation, and IFN-gamma production of gammadelta T cells in the culture of PBMC, it failed to induce any of these activities in the culture of purified primary gammadelta T cells. Pamidronate 15-26 interferon gamma Homo sapiens 71-80 11422207-3 2001 We examined whether IFN-gamma and IL-4 affect the balance between intracellular reduced glutathione (GSH) and oxidized (GSSG) glutathione, as this may affect IL-12 production in human alveolar macrophages (AM). Glutathione Disulfide 120-124 interferon gamma Homo sapiens 20-29 11313389-4 2001 By adding back the purified monocytes, however, both cell clustering and IFN-gamma production of gammadelta T cells by pamidronate could be restored. Pamidronate 119-130 interferon gamma Homo sapiens 73-82 11313389-5 2001 The pamidronate-pulsed, but not untreated, myelomonocytic line, THP-1, was capable of activating the purified gammadelta T cells to produce IFN-gamma, which was associated with the down-regulation of gammadelta TCR. Pamidronate 4-15 interferon gamma Homo sapiens 140-149 11422207-3 2001 We examined whether IFN-gamma and IL-4 affect the balance between intracellular reduced glutathione (GSH) and oxidized (GSSG) glutathione, as this may affect IL-12 production in human alveolar macrophages (AM). Glutathione 126-137 interferon gamma Homo sapiens 20-29 11422207-8 2001 Furthermore, exposure of AM to the helper T cell type 1 (Th1) cytokine IFN-gamma or the helper T cell type 2 (Th2) cytokine IL-4 for 72 h increased and decreased the GSH/GSSG ratio, respectively. Glutathione 166-169 interferon gamma Homo sapiens 71-80 11422207-8 2001 Furthermore, exposure of AM to the helper T cell type 1 (Th1) cytokine IFN-gamma or the helper T cell type 2 (Th2) cytokine IL-4 for 72 h increased and decreased the GSH/GSSG ratio, respectively. Glutathione Disulfide 170-174 interferon gamma Homo sapiens 71-80 11422207-10 2001 These results suggest that IFN-gamma and IL-4 oppositely affect the GSH/GSSG balance, which may regulate IL-12 secretion from AM in response to LPS. Glutathione 68-71 interferon gamma Homo sapiens 27-36 11422207-10 2001 These results suggest that IFN-gamma and IL-4 oppositely affect the GSH/GSSG balance, which may regulate IL-12 secretion from AM in response to LPS. Glutathione Disulfide 72-76 interferon gamma Homo sapiens 27-36 11377468-0 2001 Mycophenolate mofetil interferes with interferon gamma production in T-cell activation models. Mycophenolic Acid 0-21 interferon gamma Homo sapiens 38-54 11306718-7 2001 In cells stimulated with IFN-gamma and LPS in Arg-free medium, CPD activity increased 2- to 3-fold between 8 and 16 h after treatment, but did not change in cells stimulated in medium containing 0.4 mM Arg. Arginine 46-49 interferon gamma Homo sapiens 25-34 11306718-7 2001 In cells stimulated with IFN-gamma and LPS in Arg-free medium, CPD activity increased 2- to 3-fold between 8 and 16 h after treatment, but did not change in cells stimulated in medium containing 0.4 mM Arg. Arginine 202-205 interferon gamma Homo sapiens 25-34 11108714-5 2001 Interleukin-1 (IL-1) appears to mediate dsRNA + IFN-gamma-induced islet damage in a nitric oxide-dependent manner, as the interleukin-1 receptor antagonist protein prevents dsRNA + IFN-gamma-induced iNOS expression, inhibition of insulin secretion, and islet degeneration. Nitric Oxide 84-96 interferon gamma Homo sapiens 48-57 11108714-5 2001 Interleukin-1 (IL-1) appears to mediate dsRNA + IFN-gamma-induced islet damage in a nitric oxide-dependent manner, as the interleukin-1 receptor antagonist protein prevents dsRNA + IFN-gamma-induced iNOS expression, inhibition of insulin secretion, and islet degeneration. Nitric Oxide 84-96 interferon gamma Homo sapiens 181-190 11108714-9 2001 In addition, poly(I-C) + IFN-gamma-induced iNOS expression and nitric oxide production by human islets are prevented by interleukin-1 receptor antagonist protein, indicating that human islets respond to dsRNA and IFN-gamma in a manner similar to rat islets. Poly I-C 13-21 interferon gamma Homo sapiens 25-34 11108714-9 2001 In addition, poly(I-C) + IFN-gamma-induced iNOS expression and nitric oxide production by human islets are prevented by interleukin-1 receptor antagonist protein, indicating that human islets respond to dsRNA and IFN-gamma in a manner similar to rat islets. Poly I-C 13-21 interferon gamma Homo sapiens 213-222 11108714-9 2001 In addition, poly(I-C) + IFN-gamma-induced iNOS expression and nitric oxide production by human islets are prevented by interleukin-1 receptor antagonist protein, indicating that human islets respond to dsRNA and IFN-gamma in a manner similar to rat islets. Nitric Oxide 63-75 interferon gamma Homo sapiens 25-34 11108714-11 2001 The viral replicative intermediate dsRNA stimulates beta-cell production of pro-IL-1beta, and following cleavage to its mature form by IFN-gamma-activated ICE, IL-1 then initiates beta-cell damage in a nitric oxide-dependent fashion. Nitric Oxide 202-214 interferon gamma Homo sapiens 135-144 11380697-7 2001 There was significant induction of immunoglobulin G2a (IgG2a) and interferon-gamma (IFN-gamma) in pCMV160IIIB vaccine with zymosan. Zymosan 123-130 interferon gamma Homo sapiens 66-82 11380697-7 2001 There was significant induction of immunoglobulin G2a (IgG2a) and interferon-gamma (IFN-gamma) in pCMV160IIIB vaccine with zymosan. Zymosan 123-130 interferon gamma Homo sapiens 84-93 11785930-2 2001 In the present study we attempted to find out whether imipramine, one of the most frequently used antidepressant drugs, interfered with glucocorticoids, modulating the production of IFN-gamma and IL-10, pro-inflammatory and anti-inflammatory cytokines, respectively. Imipramine 54-64 interferon gamma Homo sapiens 182-191 11785930-3 2001 We observed a significant inhibitory effect of hydrocortisone, dexamethasone and the glucocorticoid receptor agonist RU 28362, used at doses of 10(-6) and 10(-5) M, on the production of IFN-gamma and IL-10 by whole blood cells stimulated by mitogens. Hydrocortisone 47-61 interferon gamma Homo sapiens 186-195 11785930-3 2001 We observed a significant inhibitory effect of hydrocortisone, dexamethasone and the glucocorticoid receptor agonist RU 28362, used at doses of 10(-6) and 10(-5) M, on the production of IFN-gamma and IL-10 by whole blood cells stimulated by mitogens. Dexamethasone 63-76 interferon gamma Homo sapiens 186-195 11785930-3 2001 We observed a significant inhibitory effect of hydrocortisone, dexamethasone and the glucocorticoid receptor agonist RU 28362, used at doses of 10(-6) and 10(-5) M, on the production of IFN-gamma and IL-10 by whole blood cells stimulated by mitogens. 11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one 117-125 interferon gamma Homo sapiens 186-195 11785930-5 2001 A combination of imipramine and dexamethasone or hydrocortisone at doses of 10(-6) or 10(-5) M significantly suppressed the production of IFN-gamma and IL-10, the level of inhibition being similar to that observed for glucocorticoids alone. Imipramine 17-27 interferon gamma Homo sapiens 138-147 11785930-5 2001 A combination of imipramine and dexamethasone or hydrocortisone at doses of 10(-6) or 10(-5) M significantly suppressed the production of IFN-gamma and IL-10, the level of inhibition being similar to that observed for glucocorticoids alone. Dexamethasone 32-45 interferon gamma Homo sapiens 138-147 11785930-5 2001 A combination of imipramine and dexamethasone or hydrocortisone at doses of 10(-6) or 10(-5) M significantly suppressed the production of IFN-gamma and IL-10, the level of inhibition being similar to that observed for glucocorticoids alone. Hydrocortisone 49-63 interferon gamma Homo sapiens 138-147 11278357-10 2001 Instead, caspase inhibitors directed IFNgamma/TNFalpha-treated ME-180 cells to undergo necrosis, as demonstrated by Hoechst 33258/propidium iodide staining and electron microscopy. Bisbenzimidazole 116-129 interferon gamma Homo sapiens 37-45 11278357-10 2001 Instead, caspase inhibitors directed IFNgamma/TNFalpha-treated ME-180 cells to undergo necrosis, as demonstrated by Hoechst 33258/propidium iodide staining and electron microscopy. Propidium 130-146 interferon gamma Homo sapiens 37-45 11414736-5 2001 The IFN-gamma promoted significant upregulation of Fas on the surface of colon carcinoma cells and sensitized these targets to Fas-mediated apoptosis and Ag-specific CD8(+) cytotoxic T lymphocyte (CTL)-mediated lysis involving a Fas-based effector mechanism. ammonium ferrous sulfate 51-54 interferon gamma Homo sapiens 4-13 11414736-5 2001 The IFN-gamma promoted significant upregulation of Fas on the surface of colon carcinoma cells and sensitized these targets to Fas-mediated apoptosis and Ag-specific CD8(+) cytotoxic T lymphocyte (CTL)-mediated lysis involving a Fas-based effector mechanism. ammonium ferrous sulfate 127-130 interferon gamma Homo sapiens 4-13 11357887-4 2001 The splenocytes were treated with histamine in the presence or absence of JAK-STAT inhibitor, tyrphostin, activated with IFNgamma for 30 min, and phosphorylated STAT1 was detected by immunoblotting. Histamine 34-43 interferon gamma Homo sapiens 121-129 11238005-6 2001 Treatment of the animals with the ET receptor antagonist bosentan resulted in a substantial decrease in the concentrations of tumor necrosis factor-alpha, IL-4, IL-1beta, interferon-gamma, and ET-1 in bronchoalveolar lavage fluid. Bosentan 57-65 interferon gamma Homo sapiens 171-187 11287371-0 2001 Treatment of multiple sclerosis with Copaxone (COP): Elispot assay detects COP-induced interleukin-4 and interferon-gamma response in blood cells. Glatiramer Acetate 37-45 interferon gamma Homo sapiens 105-121 11357887-6 2001 We then studied the effects of tyrphostin on histamine-mediated inhibition of IFNgamma production and histamine-mediated stimulation of IL-5 and IL-10 production. Histamine 45-54 interferon gamma Homo sapiens 78-86 11357887-7 2001 Tyrphostin dose-dependently reversed the effects of histamine on IFNgamma, IL-5 and IL-10 production, as evident by ELISA. Tyrphostins 0-10 interferon gamma Homo sapiens 65-73 11357887-7 2001 Tyrphostin dose-dependently reversed the effects of histamine on IFNgamma, IL-5 and IL-10 production, as evident by ELISA. Histamine 52-61 interferon gamma Homo sapiens 65-73 11292301-11 2001 In the cyclosporine monotherapy subgroup, patients with high IFN-gamma genotype had a 61% incidence of rejection compared with only 20% in the low IFN-gamma genotype patients (OR=3.06). Cyclosporine 7-19 interferon gamma Homo sapiens 61-70 11270917-2 2001 This study was carried out to examine the effects of antidepressive agents, i.e., imipramine, venlafaxine, L-5-hydroxytryptophan, and fluoxetine on the production of interferon-gamma (IFN-gamma), a proinflammatory cytokine, and interleukin-10 (IL-10), a negative immunoregulatory cytokine. Imipramine 82-92 interferon gamma Homo sapiens 166-182 11270917-2 2001 This study was carried out to examine the effects of antidepressive agents, i.e., imipramine, venlafaxine, L-5-hydroxytryptophan, and fluoxetine on the production of interferon-gamma (IFN-gamma), a proinflammatory cytokine, and interleukin-10 (IL-10), a negative immunoregulatory cytokine. Venlafaxine Hydrochloride 94-105 interferon gamma Homo sapiens 166-182 11270917-2 2001 This study was carried out to examine the effects of antidepressive agents, i.e., imipramine, venlafaxine, L-5-hydroxytryptophan, and fluoxetine on the production of interferon-gamma (IFN-gamma), a proinflammatory cytokine, and interleukin-10 (IL-10), a negative immunoregulatory cytokine. Venlafaxine Hydrochloride 94-105 interferon gamma Homo sapiens 184-193 11270917-2 2001 This study was carried out to examine the effects of antidepressive agents, i.e., imipramine, venlafaxine, L-5-hydroxytryptophan, and fluoxetine on the production of interferon-gamma (IFN-gamma), a proinflammatory cytokine, and interleukin-10 (IL-10), a negative immunoregulatory cytokine. 5-Hydroxytryptophan 107-128 interferon gamma Homo sapiens 166-182 11270917-2 2001 This study was carried out to examine the effects of antidepressive agents, i.e., imipramine, venlafaxine, L-5-hydroxytryptophan, and fluoxetine on the production of interferon-gamma (IFN-gamma), a proinflammatory cytokine, and interleukin-10 (IL-10), a negative immunoregulatory cytokine. 5-Hydroxytryptophan 107-128 interferon gamma Homo sapiens 184-193 11270917-2 2001 This study was carried out to examine the effects of antidepressive agents, i.e., imipramine, venlafaxine, L-5-hydroxytryptophan, and fluoxetine on the production of interferon-gamma (IFN-gamma), a proinflammatory cytokine, and interleukin-10 (IL-10), a negative immunoregulatory cytokine. Fluoxetine 134-144 interferon gamma Homo sapiens 166-182 11270917-6 2001 Fluoxetine significantly decreased the production of IFN-gamma. Fluoxetine 0-10 interferon gamma Homo sapiens 53-62 11270917-9 2001 Tricyclic antidepressants, selective serotonin reuptake inhibitors, and serotonin-noradrenaline reuptake inhibitors, as well as the immediate precursor of serotonin, have a common, negative immunoregulatory effect by suppressing the IFN-gamma/IL-10 production ratio. Serotonin 72-81 interferon gamma Homo sapiens 233-242 11388614-3 2001 Using human peripheral blood-derived mononuclear cells in vitro, such toxins were shown to induce neopterin production and degradation of the amino acid tryptophan to metabolites such as kynurenine by activating indoleamine (2,3)-dioxygenase via interferon-gamma. amino acid tryptophan 142-163 interferon gamma Homo sapiens 246-262 11388614-3 2001 Using human peripheral blood-derived mononuclear cells in vitro, such toxins were shown to induce neopterin production and degradation of the amino acid tryptophan to metabolites such as kynurenine by activating indoleamine (2,3)-dioxygenase via interferon-gamma. Kynurenine 187-197 interferon gamma Homo sapiens 246-262 11388614-3 2001 Using human peripheral blood-derived mononuclear cells in vitro, such toxins were shown to induce neopterin production and degradation of the amino acid tryptophan to metabolites such as kynurenine by activating indoleamine (2,3)-dioxygenase via interferon-gamma. indolamine 212-223 interferon gamma Homo sapiens 246-262 11405550-8 2001 Therapeutic modulation of T(H1)/T(H2) imbalance in asthma and allergy by mycobacterial vaccine, specific immunotherapy and cytoline-guanosine dinucleotide motif may lead to increases in IL-12 and IFN-gamma production. cytoline-guanosine dinucleotide 123-154 interferon gamma Homo sapiens 196-205 11118442-5 2001 We have observed that interferon-gamma (IFN-gamma) sensitizes human ovarian carcinoma cell lines to TNF-alpha-mediated apoptosis and further, IFN-gamma induces the expression of the inducible nitric-oxide synthase (iNOS) and the generation of nitric oxide (NO). Nitric Oxide 243-255 interferon gamma Homo sapiens 22-38 11118442-5 2001 We have observed that interferon-gamma (IFN-gamma) sensitizes human ovarian carcinoma cell lines to TNF-alpha-mediated apoptosis and further, IFN-gamma induces the expression of the inducible nitric-oxide synthase (iNOS) and the generation of nitric oxide (NO). Nitric Oxide 243-255 interferon gamma Homo sapiens 40-49 11118442-5 2001 We have observed that interferon-gamma (IFN-gamma) sensitizes human ovarian carcinoma cell lines to TNF-alpha-mediated apoptosis and further, IFN-gamma induces the expression of the inducible nitric-oxide synthase (iNOS) and the generation of nitric oxide (NO). Nitric Oxide 243-255 interferon gamma Homo sapiens 142-151 11118442-7 2001 Treatment of AD10 cells with the NOS inhibitor l-NMA blocked the IFN-gamma-dependent sensitization whereas NO donors (S-nitroso-N-acetylpenicillamine) sensitized these cells to TNF-alpha cytotoxicity. l-nma 47-52 interferon gamma Homo sapiens 65-74 11257077-8 2001 Most importantly, STAT-1 complexes were found in nuclear extracts prepared from freshly isolated monocytes of patients with UA, which provides compelling evidence for IFN-gamma signaling in vivo. ulmoside A 124-126 interferon gamma Homo sapiens 167-176 11283520-9 2001 Treatment with NO synthesis inhibitors such as L -N(G)-monomethyl arginine (L -NMMA) or L -N(G)-nitroarginine methyl ester hydrochloride (L -NAME) partially reversed Mk growth inhibition induced by TNF-alpha and IFN-gamma, although increased NO levels returned to normal values. l -n(g)-monomethyl arginine 47-74 interferon gamma Homo sapiens 212-221 11283520-9 2001 Treatment with NO synthesis inhibitors such as L -N(G)-monomethyl arginine (L -NMMA) or L -N(G)-nitroarginine methyl ester hydrochloride (L -NAME) partially reversed Mk growth inhibition induced by TNF-alpha and IFN-gamma, although increased NO levels returned to normal values. l -n(g)-nitroarginine methyl ester hydrochloride 88-136 interferon gamma Homo sapiens 212-221 11106650-9 2001 IFN-gamma treatment of 3T3-L1 adipocytes (48-96 h) resulted in a substantial inhibition of insulin-sensitive glucose uptake. Glucose 109-116 interferon gamma Homo sapiens 0-9 11292301-13 2001 When the analysis was controlled for the presence of delayed graft function, 40.5% of the high IFN-gamma genotype patients had serum creatinine levels above 200 micromol/L compared with only 14.3% of the low IFN-gamma genotype recipients at 5 years after transplantation (P=0.05). Creatinine 133-143 interferon gamma Homo sapiens 95-104 11292301-15 2001 CONCLUSION: In this study we have shown that high producer genotype for IFN-gamma may have an influence on acute rejection of kidney transplants, particularly in patients on cyclosporine monotherapy. Cyclosporine 174-186 interferon gamma Homo sapiens 72-81 11263770-7 2001 The mean level of IFNgamma and the ratio of IFNgamma to IL-4 were significantly higher in the culture supernatants of T cells stimulated with CII; these differences were more prominent in SFMC. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 142-145 interferon gamma Homo sapiens 18-26 11289434-4 2001 With injections of 100 mM KCl, IFN-gamma can be removed in the flow without damaging the acetylcysteine SAM. Potassium Chloride 26-29 interferon gamma Homo sapiens 31-40 11289434-6 2001 In an on-line procedure in the flow, a specific antibody (MD-2) against IFN-gamma is covalently attached following carbodiimide/succinimide activation of the SAM. Carbodiimides 115-127 interferon gamma Homo sapiens 72-81 11289434-6 2001 In an on-line procedure in the flow, a specific antibody (MD-2) against IFN-gamma is covalently attached following carbodiimide/succinimide activation of the SAM. succinimide 128-139 interferon gamma Homo sapiens 72-81 11263770-7 2001 The mean level of IFNgamma and the ratio of IFNgamma to IL-4 were significantly higher in the culture supernatants of T cells stimulated with CII; these differences were more prominent in SFMC. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 142-145 interferon gamma Homo sapiens 44-52 11263770-10 2001 In the CII-reactive cell lines, the increased production of IFNgamma was consistent with clonal expansion. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 7-10 interferon gamma Homo sapiens 60-68 11298119-7 2001 Both thiols caused a dose dependent down-regulation of IL-4, IL-5 and IFN-gamma levels in Th0 and Th2 clones, with the most pronounced decrease of IL-4. Sulfhydryl Compounds 5-11 interferon gamma Homo sapiens 70-79 11315506-0 2001 Effect of interferon-gamma on the susceptibility to Fas (CD95/APO-1)-mediated cell death in human hepatoma cells. ammonium ferrous sulfate 52-55 interferon gamma Homo sapiens 10-26 11315506-1 2001 Many tumors, including hepatocellular carcinomas (HCCs), resist Fas-mediated cell death, which is one of the effector mechanisms in the host"s anti-tumor response; however, this resistance can be abolished by interferon-gamma (IFN-gamma). ammonium ferrous sulfate 64-67 interferon gamma Homo sapiens 209-225 11315506-1 2001 Many tumors, including hepatocellular carcinomas (HCCs), resist Fas-mediated cell death, which is one of the effector mechanisms in the host"s anti-tumor response; however, this resistance can be abolished by interferon-gamma (IFN-gamma). ammonium ferrous sulfate 64-67 interferon gamma Homo sapiens 227-236 11315506-2 2001 IFN-gamma may sensitize Fas-mediated cell death in several ways, but the exact mechanism in HCCs is uncertain. ammonium ferrous sulfate 24-27 interferon gamma Homo sapiens 0-9 11315506-3 2001 In this study, we thoroughly investigated the effect of IFN-gamma on the susceptibility of one human normal liver cell line and 12 HCC cell lines to Fas-mediated cell death. ammonium ferrous sulfate 149-152 interferon gamma Homo sapiens 56-65 11315506-6 2001 When cells were pretreated with IFN-gamma, only three cell lines were made significantly susceptible to Fas-mediated cell death (SNU-354, SNU-387 and SNU-423); the other 10 cell lines were not affected. ammonium ferrous sulfate 104-107 interferon gamma Homo sapiens 32-41 11315506-8 2001 The strongly sensitized cell lines (SNU-354, SNU-387 and SNU-423) showed a particularly potent increment in surface Fas after IFN-gamma treatment (increase in surface Fas > 1.7-fold). 4-(1H-Pyrrol-1-yl)aniline 36-39 interferon gamma Homo sapiens 126-135 11315506-8 2001 The strongly sensitized cell lines (SNU-354, SNU-387 and SNU-423) showed a particularly potent increment in surface Fas after IFN-gamma treatment (increase in surface Fas > 1.7-fold). 4-(1H-Pyrrol-1-yl)aniline 45-48 interferon gamma Homo sapiens 126-135 11315506-8 2001 The strongly sensitized cell lines (SNU-354, SNU-387 and SNU-423) showed a particularly potent increment in surface Fas after IFN-gamma treatment (increase in surface Fas > 1.7-fold). ammonium ferrous sulfate 116-119 interferon gamma Homo sapiens 126-135 11315506-8 2001 The strongly sensitized cell lines (SNU-354, SNU-387 and SNU-423) showed a particularly potent increment in surface Fas after IFN-gamma treatment (increase in surface Fas > 1.7-fold). ammonium ferrous sulfate 167-170 interferon gamma Homo sapiens 126-135 11315506-10 2001 We conclude that IFN-gamma cannot play a sensitizing role in most HCC cell lines and that IFN-gamma makes HCC cells susceptible to Fas-mediated cell death through a marked up-regulation of surface Fas in some HCC cells. ammonium ferrous sulfate 131-134 interferon gamma Homo sapiens 90-99 11298134-0 2001 Treatment with ribavirin and interferon-alpha reduces interferon-gamma expression in patients with chronic hepatitis C. Recent studies in vitro and in animals have suggested that ribavirin may potentiate the antihepatitis C virus (HCV) activity of interferon-alpha (IFN-alpha) by up-modulating the production of T cell-derived cytokines, such as interleukin (IL)-2 and IFN-gamma, which play a key role in the cellular immune response against HCV. Ribavirin 15-24 interferon gamma Homo sapiens 54-70 11241298-3 2001 However, in presence of IFN-gamma or TNF-alpha, the superoxide anion (O(2)(-)) production, the p47phox, gp91phox and p22phox expression, and the binding of PU.1 and CP-1 to DNA are maintained at the high levels observed in blood monocytes. Superoxides 52-68 interferon gamma Homo sapiens 24-33 11241298-3 2001 However, in presence of IFN-gamma or TNF-alpha, the superoxide anion (O(2)(-)) production, the p47phox, gp91phox and p22phox expression, and the binding of PU.1 and CP-1 to DNA are maintained at the high levels observed in blood monocytes. Superoxides 70-74 interferon gamma Homo sapiens 24-33 11241298-5 2001 These oligonucleotides abrogated the maintenance of gp91phox and p22phox expression by IFN-gamma and TNF-alpha, but did not inhibit the effect of these cytokines on p47phox expression and O(2)(-) production. Oligonucleotides 6-22 interferon gamma Homo sapiens 87-96 11241298-7 2001 However, the preservation of O(2)(-) production by IFN-gamma and TNF-alpha is unrelated to their effect on gp91phox and p22phox expression. Superoxides 29-34 interferon gamma Homo sapiens 51-60 11405518-2 2001 Beryllium induces interferon-gamma (IFN-gamma), interleukin-2 (IL-2), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) from BAL cells. Beryllium 0-9 interferon gamma Homo sapiens 18-34 11405518-2 2001 Beryllium induces interferon-gamma (IFN-gamma), interleukin-2 (IL-2), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) from BAL cells. Beryllium 0-9 interferon gamma Homo sapiens 36-45 11405518-11 2001 Compared to the unstimulated CBD PBMNs, beryllium stimulated significant IFN-gamma, TNF-alpha, IL-2, IL-6 and IL-10 production. Beryllium 40-49 interferon gamma Homo sapiens 73-82 11241739-7 2001 Although we could induce caspase 8 in HFA with the inflammatory cytokines IFNgamma and TNFalpha, HFA remained resistant to Fas-mediated injury. hfa 38-41 interferon gamma Homo sapiens 74-82 11179490-7 2001 MTT assay revealed that low dose IFN-gamma (1-10 ng/ml) had no effect on growth of COLO205 cells, but that high dose IFN-gamma (>100 ng/ml) significantly inhibited their proliferation. monooxyethylene trimethylolpropane tristearate 0-3 interferon gamma Homo sapiens 33-42 11179490-7 2001 MTT assay revealed that low dose IFN-gamma (1-10 ng/ml) had no effect on growth of COLO205 cells, but that high dose IFN-gamma (>100 ng/ml) significantly inhibited their proliferation. monooxyethylene trimethylolpropane tristearate 0-3 interferon gamma Homo sapiens 117-126 11298134-0 2001 Treatment with ribavirin and interferon-alpha reduces interferon-gamma expression in patients with chronic hepatitis C. Recent studies in vitro and in animals have suggested that ribavirin may potentiate the antihepatitis C virus (HCV) activity of interferon-alpha (IFN-alpha) by up-modulating the production of T cell-derived cytokines, such as interleukin (IL)-2 and IFN-gamma, which play a key role in the cellular immune response against HCV. Ribavirin 15-24 interferon gamma Homo sapiens 369-378 11298134-0 2001 Treatment with ribavirin and interferon-alpha reduces interferon-gamma expression in patients with chronic hepatitis C. Recent studies in vitro and in animals have suggested that ribavirin may potentiate the antihepatitis C virus (HCV) activity of interferon-alpha (IFN-alpha) by up-modulating the production of T cell-derived cytokines, such as interleukin (IL)-2 and IFN-gamma, which play a key role in the cellular immune response against HCV. Ribavirin 179-188 interferon gamma Homo sapiens 54-70 11298134-0 2001 Treatment with ribavirin and interferon-alpha reduces interferon-gamma expression in patients with chronic hepatitis C. Recent studies in vitro and in animals have suggested that ribavirin may potentiate the antihepatitis C virus (HCV) activity of interferon-alpha (IFN-alpha) by up-modulating the production of T cell-derived cytokines, such as interleukin (IL)-2 and IFN-gamma, which play a key role in the cellular immune response against HCV. Ribavirin 179-188 interferon gamma Homo sapiens 369-378 11298134-2 2001 After 16 weeks of treatment, both the expression of IFN-gamma by activated T cells and the blood levels of IFN-gamma, were significantly reduced with respect to pretreatment values in patients treated with ribavirin and IFN-alpha but not in those undergoing treatment with IFN-alpha alone. Ribavirin 206-215 interferon gamma Homo sapiens 52-61 11332652-3 2001 Enhanced INFgamma production was not induced by either anti-CD3 or PMA alone, or anti-CD3 or ConA with anti-CD28, or enhanced by N-acetylcysteine. Acetylcysteine 129-145 interferon gamma Homo sapiens 9-17 11298134-2 2001 After 16 weeks of treatment, both the expression of IFN-gamma by activated T cells and the blood levels of IFN-gamma, were significantly reduced with respect to pretreatment values in patients treated with ribavirin and IFN-alpha but not in those undergoing treatment with IFN-alpha alone. Ribavirin 206-215 interferon gamma Homo sapiens 107-116 11298134-6 2001 In addition, our findings suggest that ribavirin may exert an anti-inflammatory effect and may help reducing IFN-gamma-driven T cell activation and liver damage. Ribavirin 39-48 interferon gamma Homo sapiens 109-118 11331037-6 2001 DEX decreased IFN-gamma production and increased IL-4 and IL-10 production by tetanus-stimulated PBMC. Dexamethasone 0-3 interferon gamma Homo sapiens 14-23 11265774-5 2001 Additionally, lactacystin, a specific proteasome inhibitor, significantly abrogated the effects of IFN-gamma and, in part, also those of CD40L or PC. lactacystin 14-25 interferon gamma Homo sapiens 99-108 11265774-6 2001 The ability of DC + ATC to cross-prime TAA-inexperienced ("naive") T cells was significantly enhanced by PC and CD40L or CD40L + IFN-gamma, but not by IFN-gamma alone. dc + atc 15-23 interferon gamma Homo sapiens 129-138 11265774-6 2001 The ability of DC + ATC to cross-prime TAA-inexperienced ("naive") T cells was significantly enhanced by PC and CD40L or CD40L + IFN-gamma, but not by IFN-gamma alone. dc + atc 15-23 interferon gamma Homo sapiens 151-160 11331037-7 2001 The addition of either recombinant IL-12p70 or IFN-gamma abrogated the DEX-mediated decrease in IFN-gamma and increase in IL-4 production. Dexamethasone 71-74 interferon gamma Homo sapiens 47-56 11331037-7 2001 The addition of either recombinant IL-12p70 or IFN-gamma abrogated the DEX-mediated decrease in IFN-gamma and increase in IL-4 production. Dexamethasone 71-74 interferon gamma Homo sapiens 96-105 11449073-5 2001 Additionally, lactacystin, a specific proteasome inhibitor, significantly abrogated the effects of IFN-gamma and, in part, also those of CD40L or PC. lactacystin 14-25 interferon gamma Homo sapiens 99-108 11331037-8 2001 Neutralization of IL-4 activity partially abrogated the DEX-induced alterations in IFN-gamma and IL-4, but not IL-10, production. Dexamethasone 56-59 interferon gamma Homo sapiens 83-92 11230514-6 2001 This also applies when L-tryptophan degradation has been stimulated by interferon-gamma. Tryptophan 23-35 interferon gamma Homo sapiens 71-87 11449073-6 2001 The ability of DC + ATC to cross-prime TAA-inexperienced ("naive") T cells was significantly enhanced by PC and CD40L or CD40L + IFN-gamma, but not by IFN-gamma alone. dc + atc 15-23 interferon gamma Homo sapiens 129-138 11449073-6 2001 The ability of DC + ATC to cross-prime TAA-inexperienced ("naive") T cells was significantly enhanced by PC and CD40L or CD40L + IFN-gamma, but not by IFN-gamma alone. dc + atc 15-23 interferon gamma Homo sapiens 151-160 11164989-8 2001 It has been demonstrated that both CD4(+) and CD8(+)-lidocaine-specific T cell clones isolated from patients with allergic contact dermatitis produced IFN-gamma, even though CD8(+) clones only produce IFN-gamma, while IFN-gamma producing CD4(+) cells concomitantly produced IL-5 and IL-4. Lidocaine 53-62 interferon gamma Homo sapiens 151-160 11401420-1 2001 Treatment of MC3T3E-1 osteoblast cultures with combined interferon- gamma(IFN- gamma), lipopolysaccharide (LPS) and tumor necrosis factor- alpha(TNF- alpha) induces expressions of inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), resulting in sustained releases of large amounts of nitric oxide and IL-6. Nitric Oxide 190-202 interferon gamma Homo sapiens 68-84 11288761-7 2001 Addition of phorbol 12-myristate 13-acetate to the cultures rendered the cells resistant to dexamethasone with regard to proliferation and IL-10 and IFN-gamma production, but not to IL-2 and TNF-alpha production in both patients and controls. Tetradecanoylphorbol Acetate 12-43 interferon gamma Homo sapiens 149-158 11226290-0 2001 Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells. trichostatin A 0-14 interferon gamma Homo sapiens 72-88 11226290-3 2001 Here, we demonstrate that the histone deacetylase inhibitor, trichostatin A, significantly down-regulated CD154 and IL-10 and up-regulated IFN-gamma gene expression in SLE T cells. trichostatin A 61-75 interferon gamma Homo sapiens 139-148 11164989-8 2001 It has been demonstrated that both CD4(+) and CD8(+)-lidocaine-specific T cell clones isolated from patients with allergic contact dermatitis produced IFN-gamma, even though CD8(+) clones only produce IFN-gamma, while IFN-gamma producing CD4(+) cells concomitantly produced IL-5 and IL-4. Lidocaine 53-62 interferon gamma Homo sapiens 201-210 11164989-8 2001 It has been demonstrated that both CD4(+) and CD8(+)-lidocaine-specific T cell clones isolated from patients with allergic contact dermatitis produced IFN-gamma, even though CD8(+) clones only produce IFN-gamma, while IFN-gamma producing CD4(+) cells concomitantly produced IL-5 and IL-4. Lidocaine 53-62 interferon gamma Homo sapiens 201-210 11229479-9 2001 Compared with HC, WG TCL showed increased production of IFNgamma (P = 0.021), IL-5 (P = 0.043), and IL-13 (P = 0.021). Triclosan 21-24 interferon gamma Homo sapiens 56-64 11207651-7 2001 Albendazole induced elimination/or reduction in intestinal worms resulting in a significant improvement in T cell proliferation and in interferon-gamma production by peripheral blood mononuclear cells (PBMC) stimulated with PPD. Albendazole 0-11 interferon gamma Homo sapiens 135-151 11266329-9 2001 Patients with HCB blood levels above the mean of 1,109 ng/L more often had undetectable IFN-[gamma] blood levels than patients below the mean. Hexachlorobenzene 14-17 interferon gamma Homo sapiens 88-98 11266329-15 2001 Our data suggest that long-term exposure of patients to HCB suppresses IFN-[gamma] production. Hexachlorobenzene 56-59 interferon gamma Homo sapiens 71-81 11272138-5 2001 Treatment of rat and human islets with dsRNA in the form of polyinosinic-polycytidylic acid (poly IC) and IFN-gamma resulted in iNOS expression and nitric oxide production. Nitric Oxide 148-160 interferon gamma Homo sapiens 106-115 11272138-7 2001 Incubation of rat islets for 3 h or human islets for 2 h with poly IC alone or poly IC + IFN-gamma resulted in NF-kappaB nuclear translocation and degradation of the NF-kappaB inhibitor protein, IkappaB, events that are prevented by MG-132. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 233-239 interferon gamma Homo sapiens 89-98 11180096-4 2001 With regard to the down-regulatory cytokines we observed that IL-4 as well as IL-13, but not IL-10, induced significant inhibition of IFN-gamma-induced control of parasite replication, INDO mRNA expression and tryptophan catabolism. Tryptophan 210-220 interferon gamma Homo sapiens 134-143 11207652-8 2001 Intracytoplasmic staining of cell lines after phorbol myristate acetate stimulation resulted in dominance of interferon-gamma (IFN-gamma)-IL-4 double-positive cells, whereas antigen stimulation resulted in production of IFN-gamma only. Tetradecanoylphorbol Acetate 46-71 interferon gamma Homo sapiens 109-125 11207652-8 2001 Intracytoplasmic staining of cell lines after phorbol myristate acetate stimulation resulted in dominance of interferon-gamma (IFN-gamma)-IL-4 double-positive cells, whereas antigen stimulation resulted in production of IFN-gamma only. Tetradecanoylphorbol Acetate 46-71 interferon gamma Homo sapiens 127-136 11207661-5 2001 We used polyclonal monospecific antibodies to detect cells expressing IL-2, IL-4, IL-6, IL-10 and IL-15, tumour necrosis factor (TNF-alpha) and interferon-gamma (IFN-gamma) in formalin-fixed, paraffin-embedded sections of granulation tissue from periodontitis lesions. Formaldehyde 176-184 interferon gamma Homo sapiens 144-160 11156969-4 2001 Prestimulation of macrophages for 15 h with a combination of LPS/IFN-gamma attenuated oxygen radical formation in response to TPA. Oxygen 86-92 interferon gamma Homo sapiens 65-74 11156969-4 2001 Prestimulation of macrophages for 15 h with a combination of LPS/IFN-gamma attenuated oxygen radical formation in response to TPA. Tetradecanoylphorbol Acetate 126-129 interferon gamma Homo sapiens 65-74 11156969-7 2001 We demonstrated that PPRE decoy oligonucleotides, supplied in front of LPS/IFN-gamma, allowed a full oxidative burst to recover upon TPA addition. Oligonucleotides 32-48 interferon gamma Homo sapiens 75-84 11156969-7 2001 We demonstrated that PPRE decoy oligonucleotides, supplied in front of LPS/IFN-gamma, allowed a full oxidative burst to recover upon TPA addition. Tetradecanoylphorbol Acetate 133-136 interferon gamma Homo sapiens 75-84 11360930-2 2001 Human peripheral blood mononuclear cells (PBMC) produced interferon gamma (IFN-gamma) when cultured with mitomycin C (MMC)-treated parental Colo 679 cells. Mitomycin 105-116 interferon gamma Homo sapiens 57-84 11159047-5 2001 Incubation of precision-cut lung slices with a mixture of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and interferon (IFN)-gamma resulted in contraction of airways, which was accompanied by expression of cyclooxygenase (Cox)-2 and thromboxane release into the supernatant. Thromboxanes 246-257 interferon gamma Homo sapiens 121-143 11360930-2 2001 Human peripheral blood mononuclear cells (PBMC) produced interferon gamma (IFN-gamma) when cultured with mitomycin C (MMC)-treated parental Colo 679 cells. Mitomycin 118-121 interferon gamma Homo sapiens 57-84 11276363-5 2001 In the presence of interferon-gamma (IFN-gamma), MDX-44 significantly inhibited the proliferation of CD64(+) HL-60, NB4, and U937 cells in 72-h cultures in a dose-dependent manner. mdx-44 49-55 interferon gamma Homo sapiens 19-35 11174202-5 2001 METHODS: Using triple-color flow cytometry and phorbol 12-myristate acetate/ionomycin stimulation, we measured the production of the intracellular cytokines IFN-gamma and IL-4 in CD4+ and CD8+ T cells separately, which were obtained from peripheral blood and bronchoalveolar lavage fluid (BALF) of 20 patients with sarcoidosis, and compared their cytokine expressions with those of 10 normal subjects. Ionomycin 76-85 interferon gamma Homo sapiens 157-166 11174202-7 2001 On stimulation with phorbol 12-myristate acetate/ionomycin for 4 hours, in BALF of the patients, but not in peripheral blood, we found a significant increase in the percentage of IFN-gamma-producing CD4+ T cells and a decrease in the percentage of IL-4-producing CD4+ T cells, resulting in a 3.5-fold higher ratio of IFN-gamma/IL-4-producing CD4+ T cells compared with that found in normal subjects. phorbol 12-myristate acetate 20-48 interferon gamma Homo sapiens 179-188 11174202-7 2001 On stimulation with phorbol 12-myristate acetate/ionomycin for 4 hours, in BALF of the patients, but not in peripheral blood, we found a significant increase in the percentage of IFN-gamma-producing CD4+ T cells and a decrease in the percentage of IL-4-producing CD4+ T cells, resulting in a 3.5-fold higher ratio of IFN-gamma/IL-4-producing CD4+ T cells compared with that found in normal subjects. phorbol 12-myristate acetate 20-48 interferon gamma Homo sapiens 317-326 11174202-7 2001 On stimulation with phorbol 12-myristate acetate/ionomycin for 4 hours, in BALF of the patients, but not in peripheral blood, we found a significant increase in the percentage of IFN-gamma-producing CD4+ T cells and a decrease in the percentage of IL-4-producing CD4+ T cells, resulting in a 3.5-fold higher ratio of IFN-gamma/IL-4-producing CD4+ T cells compared with that found in normal subjects. Ionomycin 49-58 interferon gamma Homo sapiens 179-188 11174202-7 2001 On stimulation with phorbol 12-myristate acetate/ionomycin for 4 hours, in BALF of the patients, but not in peripheral blood, we found a significant increase in the percentage of IFN-gamma-producing CD4+ T cells and a decrease in the percentage of IL-4-producing CD4+ T cells, resulting in a 3.5-fold higher ratio of IFN-gamma/IL-4-producing CD4+ T cells compared with that found in normal subjects. Ionomycin 49-58 interferon gamma Homo sapiens 317-326 11322649-7 2001 Western blot analysis revealed that, in IFN-gamma-differentiated U937 cells, the expression of Fas (CD95/APO-1) & Fas ligand(FasL) increases the apoptotic sensitivity against Mistletoe lectin-II. Adenosine Monophosphate 113-116 interferon gamma Homo sapiens 40-49 11180008-10 2001 The ability of interferon-gamma to induce the transcription repressor BCL-6 may also contribute to the overall immunologic events in skin, including suppression of the intermediates in the synthetic pathway leading to expression of the T cell costimulatory ganglioside CDw60. Gangliosides 257-268 interferon gamma Homo sapiens 15-31 11276363-5 2001 In the presence of interferon-gamma (IFN-gamma), MDX-44 significantly inhibited the proliferation of CD64(+) HL-60, NB4, and U937 cells in 72-h cultures in a dose-dependent manner. mdx-44 49-55 interferon gamma Homo sapiens 37-46 11276363-11 2001 The effect of MDX-44 on AML cells was dependent on activation of cells by IFN-gamma. mdx-44 14-20 interferon gamma Homo sapiens 74-83 11242299-6 2001 RESULTS: Lipopolysaccharide-induced release of tumor necrosis factor-alpha, interleukin (IL)-6, IL-12, and IL-1Ra, and prostaglandin E2 was clearly augmented with IFN-gamma most strikingly postoperatively (p < 0.05). Dinoprostone 119-135 interferon gamma Homo sapiens 163-172 11210867-5 2001 The purpose of this study was to investigate the profile of cytokines IFNgamma and IL-4 that occurs in vivo in anti-H2-treated patients with allergic rhinitis (AR). Hydrogen 116-118 interferon gamma Homo sapiens 70-78 11210867-9 2001 CONCLUSION: H2 antagonists probably induce their effects by enhancing the amount of IFN-gamma and by reducing IL-4 cytokines, which, respectively, induce a decrease and an increase in the IgE synthesis. Hydrogen 12-14 interferon gamma Homo sapiens 84-93 11236937-2 2001 We have previously shown that IFN-gamma restores phorbol ester-induced differentiation and cell cycle arrest in v-myc transformed human U-937 monoblasts. Phorbol Esters 49-62 interferon gamma Homo sapiens 30-39 11286023-1 2001 The mechanism of increased chloride currents by inflammatory cytokine, interferon-gamma (IFN-gamma), was investigated in cultured a human bronchial epithelial cell line (BEAS-2B) using cell-attached and inside-out patch configurations. Chlorides 27-35 interferon gamma Homo sapiens 71-87 11286023-1 2001 The mechanism of increased chloride currents by inflammatory cytokine, interferon-gamma (IFN-gamma), was investigated in cultured a human bronchial epithelial cell line (BEAS-2B) using cell-attached and inside-out patch configurations. Chlorides 27-35 interferon gamma Homo sapiens 89-98 11286023-5 2001 Erythromycin, a macrolide antibiotic, at a concentration of 100 microM inhibited the activation of ORCC induced by IFN-gamma. Erythromycin 0-12 interferon gamma Homo sapiens 115-124 11286023-5 2001 Erythromycin, a macrolide antibiotic, at a concentration of 100 microM inhibited the activation of ORCC induced by IFN-gamma. Macrolides 16-25 interferon gamma Homo sapiens 115-124 11819731-16 2001 Hydroxyl proline contents were 2.83 +/- 1.18, 3.59 +/- 1.22 and 4.80 +/- 1.62, in the three IFN-gamma groups, and 10.01 +/- 3.23 in fibrotic model group. Proline 9-16 interferon gamma Homo sapiens 92-101 11819731-20 2001 Hydroxyl proline contents were 2.72 +/- 0.58, 3.14 +/- 0.71 and 3.62 +/- 1.02, in the three IFN-gamma groups, and 12.79 +/- 1.54 in fibrotic model group. Proline 9-16 interferon gamma Homo sapiens 92-101 11160202-6 2001 As a result, T cell lines generated from allogeneic naive CD45RA(+) T cells primed with DCs matured in the presence of ATP produced lower amounts of IFN-gamma and higher levels of IL-4, IL-5, and IL-10 compared with T cell lines obtained with LPS-stimulated DCs. Adenosine Triphosphate 119-122 interferon gamma Homo sapiens 149-158 11175814-1 2001 Interleukin-12 (IL-12) and IL-18 induce synergistic transcription of interferon gamma (IFN-gamma) that is T cell receptor (TCR)-independent, not inhibited by cyclosporin A and requires new protein synthesis. Cyclosporine 158-171 interferon gamma Homo sapiens 69-96 11146231-3 2001 By employing a functional approach we examined the role of DAP-5 in human neuroblastoma cells that are sensitized for IFNgamma-induced apoptosis by tetracycline controlled MYCN expression. Tetracycline 148-160 interferon gamma Homo sapiens 118-126 11219190-0 2001 The HMG-CoA reductase inhibitor simvastatin inhibits IFN-gamma induced MHC class II expression in human vascular endothelial cells. Simvastatin 32-43 interferon gamma Homo sapiens 53-62 11219190-5 2001 Using RNAse protection assay and flow cytometry, we observed that simvastatin dose-dependently reduced interferon-gamma (IFN-gamma) induced MHC class II expression (mRNA and protein). Simvastatin 66-77 interferon gamma Homo sapiens 103-130 11145664-4 2001 PGE(2) significantly suppressed NK cell-mediated cytotoxicity and IFN-gamma production at the secretional and the transcriptional levels. Prostaglandins E 0-3 interferon gamma Homo sapiens 66-75 11219190-11 2001 In conclusion, simvastatin selectively decreases IFN-gamma-induced MHC class II expression in human primary endothelial cells through actions on the CIITA promoter IV. Simvastatin 15-26 interferon gamma Homo sapiens 49-58 11145908-4 2001 In addition, IL-12 p40 promoter activity was repressed by the presence of HCV core in macrophages stimulated with lipopolysaccharride (LPS) following IFN-gamma treatment, indicating that IL-12 production may be downregulated at the transcriptional level. lipopolysaccharride 114-133 interferon gamma Homo sapiens 150-159 11145678-1 2001 We have investigated the chemokine receptor expression and migratory behavior of a new subset of nickel-specific skin-homing regulatory CD4(+) T cells (Th(IL-10)) releasing high levels of IL-10, low IFN-gamma, and undetectable IL-4. Nickel 97-103 interferon gamma Homo sapiens 199-208 11145847-5 2001 IFN-gamma ELISPOT and(51)Cr release assays showed excellent correlation suggesting that NK activity can be reliably evaluated with methods other than the traditional(51)Cr release assays. Chromium 169-171 interferon gamma Homo sapiens 0-9 11604049-5 2001 Alteration of synthesis and release of cytokines such as interleukin (IL)-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12 and interferon-gamma is involved in the complex mechanisms of thalidomide. Thalidomide 176-187 interferon gamma Homo sapiens 118-134 11936187-0 2001 Fibronectin promotes calcium signaling by interferon-gamma in human neutrophils via G-protein and sphingosine kinase-dependent mechanisms. Calcium 21-28 interferon gamma Homo sapiens 42-58 11167428-8 2001 Propofol caused significant decreases in IL-2 levels (68%, p < 0.001) but increases in IFN-gamma (30%, p < 0.05), whereas there was no significant change with midazolam compared with the pre-infusion level. Propofol 0-8 interferon gamma Homo sapiens 90-99 11167428-10 2001 Propofol inhibited IL-2 production and stimulated IFN-gamma production, whereas midazolam failed to do so. Propofol 0-8 interferon gamma Homo sapiens 50-59 11237407-6 2001 The results indicate that HIV-infected patients on no therapy exhibit a pre-dominant Th2 response (IL-4 secretion), whereas those on the sterol/sterolin mixture exhibit a beneficial Th1 response (IFN-gamma). Sterols 137-143 interferon gamma Homo sapiens 196-205 11237407-6 2001 The results indicate that HIV-infected patients on no therapy exhibit a pre-dominant Th2 response (IL-4 secretion), whereas those on the sterol/sterolin mixture exhibit a beneficial Th1 response (IFN-gamma). lyoniside 144-152 interferon gamma Homo sapiens 196-205 11167994-7 2001 10(-5) M) and dexamethasone (10(-7) M) readily inhibited these responses and the production of other cytokines, including interferon-gamma and tumour necrosis factor-alpha. Dexamethasone 14-27 interferon gamma Homo sapiens 122-171 11141332-3 2001 Increased amounts of neopterin are produced during the Th1-type immune response by human monocytes/macrophages upon stimulation with the Th1-derived cytokine interferon-gamma, and thus the determination of neopterin concentrations allows us to monitor Th1-type immune response. Neopterin 21-30 interferon gamma Homo sapiens 158-174 11936187-2 2001 Previously, we have shown that interferon-gamma (IFN-gamma) induces transient calcium signals in PMN, but only after intracellular calcium store depletion. Calcium 78-85 interferon gamma Homo sapiens 31-47 11936187-2 2001 Previously, we have shown that interferon-gamma (IFN-gamma) induces transient calcium signals in PMN, but only after intracellular calcium store depletion. Calcium 78-85 interferon gamma Homo sapiens 49-58 11936187-2 2001 Previously, we have shown that interferon-gamma (IFN-gamma) induces transient calcium signals in PMN, but only after intracellular calcium store depletion. Calcium 131-138 interferon gamma Homo sapiens 31-47 11936187-2 2001 Previously, we have shown that interferon-gamma (IFN-gamma) induces transient calcium signals in PMN, but only after intracellular calcium store depletion. Calcium 131-138 interferon gamma Homo sapiens 49-58 11936187-3 2001 Using a digital imaging system, we show that adhesion of PMN is critical for IFN-gamma-induced calcium signals, and with PMN attached to the optimal coating, the calcium signals are evoked even in presence of extracellular calcium, that is, non-depleted calcium stores. Calcium 95-102 interferon gamma Homo sapiens 77-86 11936187-3 2001 Using a digital imaging system, we show that adhesion of PMN is critical for IFN-gamma-induced calcium signals, and with PMN attached to the optimal coating, the calcium signals are evoked even in presence of extracellular calcium, that is, non-depleted calcium stores. Calcium 162-169 interferon gamma Homo sapiens 77-86 11936187-3 2001 Using a digital imaging system, we show that adhesion of PMN is critical for IFN-gamma-induced calcium signals, and with PMN attached to the optimal coating, the calcium signals are evoked even in presence of extracellular calcium, that is, non-depleted calcium stores. Calcium 162-169 interferon gamma Homo sapiens 77-86 11936187-3 2001 Using a digital imaging system, we show that adhesion of PMN is critical for IFN-gamma-induced calcium signals, and with PMN attached to the optimal coating, the calcium signals are evoked even in presence of extracellular calcium, that is, non-depleted calcium stores. Calcium 162-169 interferon gamma Homo sapiens 77-86 11936187-5 2001 In accordance with previous observations, IFN-gamma-induced calcium signals in fibronectin adherent cells were totally abolished by the G-protein inhibitor pertussis toxin and were also inhibited by the sphingosine kinase inhibitors dimethylsphingosine (DMS) and N-acetylsphingosine (N-Ac-Sp). Calcium 60-67 interferon gamma Homo sapiens 42-51 11936187-5 2001 In accordance with previous observations, IFN-gamma-induced calcium signals in fibronectin adherent cells were totally abolished by the G-protein inhibitor pertussis toxin and were also inhibited by the sphingosine kinase inhibitors dimethylsphingosine (DMS) and N-acetylsphingosine (N-Ac-Sp). dimethylsphingosine 233-252 interferon gamma Homo sapiens 42-51 11936187-5 2001 In accordance with previous observations, IFN-gamma-induced calcium signals in fibronectin adherent cells were totally abolished by the G-protein inhibitor pertussis toxin and were also inhibited by the sphingosine kinase inhibitors dimethylsphingosine (DMS) and N-acetylsphingosine (N-Ac-Sp). dms 254-257 interferon gamma Homo sapiens 42-51 11936187-5 2001 In accordance with previous observations, IFN-gamma-induced calcium signals in fibronectin adherent cells were totally abolished by the G-protein inhibitor pertussis toxin and were also inhibited by the sphingosine kinase inhibitors dimethylsphingosine (DMS) and N-acetylsphingosine (N-Ac-Sp). N-acetylsphingosine 263-282 interferon gamma Homo sapiens 42-51 11936187-5 2001 In accordance with previous observations, IFN-gamma-induced calcium signals in fibronectin adherent cells were totally abolished by the G-protein inhibitor pertussis toxin and were also inhibited by the sphingosine kinase inhibitors dimethylsphingosine (DMS) and N-acetylsphingosine (N-Ac-Sp). N-acetylsphingosine 284-291 interferon gamma Homo sapiens 42-51 11936187-11 2001 In conclusion, fibronectin contact evokes by itself a calcium signal in PMN and further promotes calcium signaling by IFN-gamma. Calcium 97-104 interferon gamma Homo sapiens 118-127 11936187-13 2001 Apparently, sphingosine kinase activity is also involved in IFN-gamma induced calcium signals. Calcium 78-85 interferon gamma Homo sapiens 60-69 11306980-1 2001 Tyrosine phosphorylation of STAT1alpha in eosinophils after IFN-gamma stimulation has been shown, but the biological significance of eosinophil STAT1alpha activation in transmitting the signals through the IFN-gamma receptor remains unknown. Tyrosine 0-8 interferon gamma Homo sapiens 60-69 11208718-8 2001 IFN-gamma mediated its action by at least 2 mechanisms: (1) inhibition of parasite invasion and (2) by modification of intracellular Fe(2+) concentration. ammonium ferrous sulfate 133-139 interferon gamma Homo sapiens 0-9 11385231-6 2001 Dexamethasone (10(-8) M) strongly inhibited RANTES production by KCs induced by the combination of IFN-gamma and IL-4, while tacrolimus (FK-506, 10(-8) and 10(-6) M) showed partial inhibition. Dexamethasone 0-13 interferon gamma Homo sapiens 99-108 11123292-6 2001 Anti-TNF-alpha, anti-IL-2, and anti-IFN-gamma Abs, when added together to PBMC cultures, completely blocked Con A- and partially blocked anti-CD3- and PMA/ionomycin-induced monocyte HA binding. Ionomycin 155-164 interferon gamma Homo sapiens 36-45 12404604-6 2001 In vitro, it has been shown that various types of antidepressive drugs, including TCAs (imipramine; clomipramine); SSRIs (citalopram, fluoxetine, sertraline); lithium; SNRIs (venlafaxine); HCAs (trazodone); RIMAs (moclobemide) and L-5-HTP significantly suppress the ratio of IFNgamma/IL-10 production by peripheral blood immunocytes. Lithium 159-166 interferon gamma Homo sapiens 275-283 12404604-6 2001 In vitro, it has been shown that various types of antidepressive drugs, including TCAs (imipramine; clomipramine); SSRIs (citalopram, fluoxetine, sertraline); lithium; SNRIs (venlafaxine); HCAs (trazodone); RIMAs (moclobemide) and L-5-HTP significantly suppress the ratio of IFNgamma/IL-10 production by peripheral blood immunocytes. snris 168-173 interferon gamma Homo sapiens 275-283 11570676-5 2001 Silica exposure up-regulated a TH1 lymphocyte-derived cytokine, interferon gamma (IFN-gamma), and a TH2 lymphocyte-derived cytokine, interleukin-4 (IL-4). Silicon Dioxide 0-6 interferon gamma Homo sapiens 64-91 11123278-0 2001 Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells. Gangliosides 0-12 interferon gamma Homo sapiens 51-60 11123278-3 2001 Gangliosides GD1b, GT1b, and GQ1b (each 100 nM) enhanced PHA-induced IL-2 secretion of peripheral blood T cells approximately 4-fold and enhanced that of IFN-gamma 3- to 4-fold compared with controls. Gangliosides 0-12 interferon gamma Homo sapiens 154-163 11367520-7 2001 The up-regulation of IL-10 production by histamine in splenocytes was accompanied by inhibitory effects of histamine on IFN gamma production. Histamine 41-50 interferon gamma Homo sapiens 120-129 11367520-7 2001 The up-regulation of IL-10 production by histamine in splenocytes was accompanied by inhibitory effects of histamine on IFN gamma production. Histamine 107-116 interferon gamma Homo sapiens 120-129 11367520-8 2001 The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine on IFN gamma secretion were regulated by IL-10 in multi-cell system. Histamine 37-46 interferon gamma Homo sapiens 120-129 11367520-8 2001 The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine on IFN gamma secretion were regulated by IL-10 in multi-cell system. Histamine 37-46 interferon gamma Homo sapiens 185-194 11367520-8 2001 The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine on IFN gamma secretion were regulated by IL-10 in multi-cell system. Histamine 87-96 interferon gamma Homo sapiens 120-129 11367520-8 2001 The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine on IFN gamma secretion were regulated by IL-10 in multi-cell system. Histamine 87-96 interferon gamma Homo sapiens 185-194 11367520-8 2001 The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine on IFN gamma secretion were regulated by IL-10 in multi-cell system. Histamine 87-96 interferon gamma Homo sapiens 120-129 11367520-8 2001 The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine on IFN gamma secretion were regulated by IL-10 in multi-cell system. Histamine 87-96 interferon gamma Homo sapiens 185-194 11885921-3 2001 Heavy metals like CdCl2 can induce, or inhibit the synthesis and expression of the inflammatory cytokines IL-1beta, IL-4, IL-6, TNF-alpha, IFN-gamma and ICAM-1. Cadmium Chloride 18-23 interferon gamma Homo sapiens 139-148 11123278-8 2001 The cAMP analogue dibutyryl cAMP and the cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine each reversed GD1b-, GT1b-, and GQ1b-induced stimulation of IL-2 and IFN-gamma production and inhibition of IL-4 and IL-5 production at the levels of proteins, transcription, and promoter activities. Cyclic AMP 4-8 interferon gamma Homo sapiens 174-183 11123278-8 2001 The cAMP analogue dibutyryl cAMP and the cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine each reversed GD1b-, GT1b-, and GQ1b-induced stimulation of IL-2 and IFN-gamma production and inhibition of IL-4 and IL-5 production at the levels of proteins, transcription, and promoter activities. Cyclic AMP 28-32 interferon gamma Homo sapiens 174-183 11123278-8 2001 The cAMP analogue dibutyryl cAMP and the cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine each reversed GD1b-, GT1b-, and GQ1b-induced stimulation of IL-2 and IFN-gamma production and inhibition of IL-4 and IL-5 production at the levels of proteins, transcription, and promoter activities. Cyclic AMP 28-32 interferon gamma Homo sapiens 174-183 11123278-8 2001 The cAMP analogue dibutyryl cAMP and the cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine each reversed GD1b-, GT1b-, and GQ1b-induced stimulation of IL-2 and IFN-gamma production and inhibition of IL-4 and IL-5 production at the levels of proteins, transcription, and promoter activities. Colforsin 63-72 interferon gamma Homo sapiens 174-183 11123278-8 2001 The cAMP analogue dibutyryl cAMP and the cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine each reversed GD1b-, GT1b-, and GQ1b-induced stimulation of IL-2 and IFN-gamma production and inhibition of IL-4 and IL-5 production at the levels of proteins, transcription, and promoter activities. 1-Methyl-3-isobutylxanthine 77-104 interferon gamma Homo sapiens 174-183 11123292-11 2001 Moreover, anti-IFN-gamma and anti-TNF-alpha Abs blocked fixed PMA/ionomycin-activated CD4(+) T cell-induced monocyte HA binding. Ionomycin 66-75 interferon gamma Homo sapiens 15-24 11123348-10 2001 Coadministration of rIL-12 or rIL-18 induced greater IFN-gamma production in sarcoid BAL fluid cells than in normal BAL fluid cells. ril-12 20-26 interferon gamma Homo sapiens 53-62 11123302-6 2001 The enhanced secretion of IFN-gamma mediated via TRANCE correlates with the activation of p38 mitogen-activated protein kinase and is blocked by SB203580, a p38 mitogen-activated protein kinase-specific inhibitor. SB 203580 145-153 interferon gamma Homo sapiens 26-35 11123292-0 2001 Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. Hyaluronic Acid 33-43 interferon gamma Homo sapiens 96-105 11833469-6 2001 Differing from that of IL-4, IFN gamma gene expression always requires MAP-kinase activation in addition to a calcium signal. Calcium 110-117 interferon gamma Homo sapiens 29-38 11140895-4 2001 The results show that the increased collagen synthesis in vitro in response to arecoline was inhibited in the presence of IFN-gamma (0.01-10.0 U/ ml) in a dose-related way. Arecoline 79-88 interferon gamma Homo sapiens 122-131 10993881-5 2000 It appears that LIGHT and IFN-gamma act synergistically to activate caspase-3, with the resultant cleavage of Bcl-2, removal of the BH4 domain, leading to conversion of Bcl-2 from an antiapoptotic to a proapoptotic form in p53-deficient hepatocellular carcinoma Hep3BT2 cells. sapropterin 132-135 interferon gamma Homo sapiens 26-35 11163041-11 2001 CONCLUSIONS: Tyrosine phosphorylation of proteins including JAK1 and JAK2 is essential for IFN-gamma-induction of MHC class II expression, but not critical for that of ICAM-1 expression in cultured HCE cells. Tyrosine 13-21 interferon gamma Homo sapiens 91-100 12040407-0 2001 Asp(126), Asp(130) and Asp(134) are Necessary for Human IL-18 to Elicit IFN-gamma Production from PBMC. Aspartic Acid 0-3 interferon gamma Homo sapiens 72-81 11137126-7 2000 Daily intramuscular treatment of GB piglets with 1mg/kg of FK506 from birth for 4 weeks resulted in lowered (P<0.05) in vitro secretion of interferon-gamma and interleukin-8. Tacrolimus 59-64 interferon gamma Homo sapiens 142-158 11137126-9 2000 The depletions of mononuclear cells and low levels of interferon-gamma and interleukin-8 in piglets treated with FK506 were accompanied by lower proportion of CD3+, CD2+CD4+ and CD2+CD8+ T-cell phenotypes in peripheral blood but not in thymus and mesenteric lymph nodes. Tacrolimus 113-118 interferon gamma Homo sapiens 54-70 11164462-9 2000 Another subset of T cells that expresses the NK receptors is the alpha-galactosyl-ceramide specific T cell subset defined by the expression of canonical Valpha24JalphaQ TCR, recognition of CD1d and secretion of high amounts of IL-4 and IFN-gamma. alpha-galactosylceramide 65-90 interferon gamma Homo sapiens 236-245 11110692-5 2000 The apoptotic effects of fas agonists in IFN-gamma-treated human and murine FA-C cells were blocked when pretreated with inhibitors (ac-DEVD-cho, CP-DEVD-cho, Z-DEVD-FMK) of the caspase 3 protease. acetyl-aspartyl-glutamyl-valyl-aspartal 133-144 interferon gamma Homo sapiens 41-50 11110692-5 2000 The apoptotic effects of fas agonists in IFN-gamma-treated human and murine FA-C cells were blocked when pretreated with inhibitors (ac-DEVD-cho, CP-DEVD-cho, Z-DEVD-FMK) of the caspase 3 protease. cp-devd-cho 146-157 interferon gamma Homo sapiens 41-50 11110692-5 2000 The apoptotic effects of fas agonists in IFN-gamma-treated human and murine FA-C cells were blocked when pretreated with inhibitors (ac-DEVD-cho, CP-DEVD-cho, Z-DEVD-FMK) of the caspase 3 protease. benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone 159-169 interferon gamma Homo sapiens 41-50 11110692-9 2000 Therefore fas-induced apoptosis in Fanconi anemia cells of the C type involves the activation of caspase 8, which controls activation of caspase 3 family members and one direct or indirect function of the FANCC protein is to suppress apoptotic responses to IFN-gamma upstream of caspase 3 activation. ammonium ferrous sulfate 10-13 interferon gamma Homo sapiens 257-266 11563819-6 2001 Tacrolimus treatment added with donor specific BMT down-regulated IL-12 and IFN-gamma transcript, resulted in a significant prolongation of intestinal allograft survival. Tacrolimus 0-10 interferon gamma Homo sapiens 76-85 12760489-2 2001 When added to cultures of cardiomyocytes, the combined agents (LPS/IFN-gamma or TNF-alpha/IFN-gamma) had stimulatory effect on the production of IL-6 and the elevation was significantly reduced by SB203580, a specific p38 MAPK inhibitor. SB 203580 197-205 interferon gamma Homo sapiens 67-76 12760489-2 2001 When added to cultures of cardiomyocytes, the combined agents (LPS/IFN-gamma or TNF-alpha/IFN-gamma) had stimulatory effect on the production of IL-6 and the elevation was significantly reduced by SB203580, a specific p38 MAPK inhibitor. SB 203580 197-205 interferon gamma Homo sapiens 90-99 11236507-8 2001 In case of mixed infection a significant increase in the concentration of IFN-gamma was registered in the subgroup of patients with the acute form of NS+ (39.9 pg/ml). Nitrogen 150-153 interferon gamma Homo sapiens 74-83 11134660-5 2000 Indirubin exerted its inhibitory effects not only on interferon-gamma production by human myelomonocytic HBL-38 cells but also on interferon-gamma and interleukin-6 production by murine splenocytes with no influence on the proliferation of either cells. indirubin 0-9 interferon gamma Homo sapiens 53-69 11134660-5 2000 Indirubin exerted its inhibitory effects not only on interferon-gamma production by human myelomonocytic HBL-38 cells but also on interferon-gamma and interleukin-6 production by murine splenocytes with no influence on the proliferation of either cells. indirubin 0-9 interferon gamma Homo sapiens 130-146 11120844-5 2000 Using a two-separate-chambers system, we showed that Brucella fraction, as well as isopentenyl pyrophosphate-activated Vgamma9Vdelta2 T cells, impaired the multiplication of B. suis in differentiated THP-1 cells through TNF-alpha and IFN-gamma release. isopentenyl pyrophosphate 83-108 interferon gamma Homo sapiens 234-243 10993881-7 2000 Although benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethylketone and benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone can prevent the cleavage of Bcl-2 by LIGHT/IFN-gamma, they only partially inhibit apoptosis in Hep3BT2 cells that are overexpressing Bcl-2. benzyloxycarbonyl-asp-glu-val-asp-fluoromethylketone 9-61 interferon gamma Homo sapiens 158-167 10993881-7 2000 Although benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethylketone and benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone can prevent the cleavage of Bcl-2 by LIGHT/IFN-gamma, they only partially inhibit apoptosis in Hep3BT2 cells that are overexpressing Bcl-2. Caspase Inhibitor VI 66-114 interferon gamma Homo sapiens 158-167 11151933-0 2000 Early decrease of interferon-gamma+ and interleukin-2+ T cells during combination treatment with interferon-alpha and ribavirin in patients with chronic hepatitis C. Ribavirin 118-127 interferon gamma Homo sapiens 18-53 11191284-6 2000 The combination of TNFalpha+IFNgamma induced a significant decrease in cell viability as judged by methyltetrazoleum (MTT) metabolism which decreased to median 68% of unexposed cultures (P < 0.01). methyltetrazoleum 99-116 interferon gamma Homo sapiens 28-36 11191284-6 2000 The combination of TNFalpha+IFNgamma induced a significant decrease in cell viability as judged by methyltetrazoleum (MTT) metabolism which decreased to median 68% of unexposed cultures (P < 0.01). monooxyethylene trimethylolpropane tristearate 118-121 interferon gamma Homo sapiens 28-36 11156084-2 2000 Neopterin is produced and secreted by interferon-gamma-stimulated monocytic cells. Neopterin 0-9 interferon gamma Homo sapiens 38-54 11106607-4 2000 Furthermore, increases in NAD(P)H amplitude, whether mediated by interferon-gamma or by an oscillating electric field, signals increased production of reactive oxygen metabolites. Oxygen 160-166 interferon gamma Homo sapiens 65-81 11511814-2 2000 We previously remodeled the branch structures of N-glycans on hIFN-gamma in Chinese hamster ovary (CHO) cells by overexpressing UDP-N-acetylglucosamine: alpha1,6-D-mannoside beta1,6-N-acetylglucosaminyltransferase (GnT-V). -d-mannoside 161-173 interferon gamma Homo sapiens 62-72 11511814-1 2000 Natural human interferon-gamma (hIFN-gamma) contains mainly biantennary complex-type sugar chains. Sugars 85-90 interferon gamma Homo sapiens 14-30 11511814-1 2000 Natural human interferon-gamma (hIFN-gamma) contains mainly biantennary complex-type sugar chains. Sugars 85-90 interferon gamma Homo sapiens 32-42 11511814-3 2000 Normal CHO cells primarily produced hIFN-gamma having biantennary sugar chains, whereas a CHO clone, designated IM4/Vh, transfected with GnT-V, primarily produced hIFN-gamma having GlcNAcbeta1-6 branched triantennary sugar chains when sialylation was incomplete and an increase in poly-N-acetyllactosamine (Galbeta1-4GlcNAcbeta1-3)n was observed. cho 90-93 interferon gamma Homo sapiens 163-173 11511814-2 2000 We previously remodeled the branch structures of N-glycans on hIFN-gamma in Chinese hamster ovary (CHO) cells by overexpressing UDP-N-acetylglucosamine: alpha1,6-D-mannoside beta1,6-N-acetylglucosaminyltransferase (GnT-V). n-glycans 49-58 interferon gamma Homo sapiens 62-72 11511814-2 2000 We previously remodeled the branch structures of N-glycans on hIFN-gamma in Chinese hamster ovary (CHO) cells by overexpressing UDP-N-acetylglucosamine: alpha1,6-D-mannoside beta1,6-N-acetylglucosaminyltransferase (GnT-V). Uridine Diphosphate N-Acetylglucosamine 128-151 interferon gamma Homo sapiens 62-72 11086074-4 2000 Treatments that inhibit macrophage proliferation by blocking the cell cycle at the G(1) phase, such as adenosine, forskolin, or LPS, blocked the IFN-gamma induction of IA. Adenosine 103-112 interferon gamma Homo sapiens 145-154 11069239-4 2000 PBMC IFN-gamma secretion after stimulation with C. trachomatis EBs was significantly decreased in HIV-1-infected women. ethylbenzene 63-66 interferon gamma Homo sapiens 5-14 11042609-5 2000 Steady-state fluorescence emission spectra of untreated and liposome-desorbed hIFNgamma revealed that the environment of the sole Trp residue was not affected by the adsorption/desorption process. Tryptophan 130-133 interferon gamma Homo sapiens 78-87 11042609-6 2000 The Trp-36 residue remained fully quenchable by acrylamide after desorption of hIFNgamma from the liposomes. Tryptophan 4-7 interferon gamma Homo sapiens 79-88 11042609-6 2000 The Trp-36 residue remained fully quenchable by acrylamide after desorption of hIFNgamma from the liposomes. Acrylamide 48-58 interferon gamma Homo sapiens 79-88 11042609-9 2000 Disparities were detected between the average lifetimes of liposome-adsorbed hIFNgamma and hIFNgamma-liposomes, indicating that subtle changes in the Trp-36 environment took place during preparation of the liposomes via the film hydration method compared with the adsorption of hIFNgamma to the liposome surface. Tryptophan 150-153 interferon gamma Homo sapiens 77-86 11042609-9 2000 Disparities were detected between the average lifetimes of liposome-adsorbed hIFNgamma and hIFNgamma-liposomes, indicating that subtle changes in the Trp-36 environment took place during preparation of the liposomes via the film hydration method compared with the adsorption of hIFNgamma to the liposome surface. Tryptophan 150-153 interferon gamma Homo sapiens 91-100 11042609-9 2000 Disparities were detected between the average lifetimes of liposome-adsorbed hIFNgamma and hIFNgamma-liposomes, indicating that subtle changes in the Trp-36 environment took place during preparation of the liposomes via the film hydration method compared with the adsorption of hIFNgamma to the liposome surface. Tryptophan 150-153 interferon gamma Homo sapiens 91-100 11163089-3 2000 Pretreatment of allogeneic stimulator cells with HOC results in abrogation of cytotoxic T lymphocyte (CTL) activity, proliferative responses, and IFN gamma production in a 7-day MLR. (2S)-2-HYDROXYOCTANOIC ACID 49-52 interferon gamma Homo sapiens 146-155 11193379-14 2000 Similarly, dbcAMP inhibited the production of IFN-gamma and IL-2 more potently than that of IL-4 and IL-5. Bucladesine 11-17 interferon gamma Homo sapiens 46-55 11086074-4 2000 Treatments that inhibit macrophage proliferation by blocking the cell cycle at the G(1) phase, such as adenosine, forskolin, or LPS, blocked the IFN-gamma induction of IA. Colforsin 114-123 interferon gamma Homo sapiens 145-154 11067899-5 2000 The inhibitory effects of IFN-gamma/alpha on the IL-4R mRNA expression require a lag period of about 8 h, and are sensitive to cycloheximide treatment, which suggests that the suppressive effect of IFNs on IL-4R gene expression is a secondary response requiring de novo synthesis of IFN-induced factors. Cycloheximide 127-140 interferon gamma Homo sapiens 26-35 11191629-3 2000 First the induction of nitric oxide by lipopolysaccharide (LPS), tumor necrosis factor alpha (TNFalpha), interferon gamma (IFNgamma), alone or their combination, was studied in C6 glioma cells. Nitric Oxide 23-35 interferon gamma Homo sapiens 105-132 11062036-9 2000 Nevertheless, NO is not responsible for the direct inhibitory effect of the IFN-gamma treatment of fibroblasts and is only partially involved in the inhibitory effect of IFN-gamma-stimulated macrophages, which is also mediated by reactive oxygen intermediates. reactive 230-238 interferon gamma Homo sapiens 170-179 11103793-9 2000 When combined with IFN-gamma, the recombinant TNF-alpha (1-100 ng/ml) enhanced NO2- formation in JB6 P+ cells, whereas IL-1beta (1-100 ng/ml) did not. Nitrogen Dioxide 79-82 interferon gamma Homo sapiens 19-28 11070493-9 2000 DHEA was found to inhibit only the interferon-gamma component of the microglial response. Dehydroepiandrosterone 0-4 interferon gamma Homo sapiens 35-51 11205205-5 2000 RESULTS: After LNT treatment, CD4+ IFN-gamma+ T-cell percentages increased significantly (p < 0.05), whereas CD4+ IL-4+ T-cell and CD4+ IL-6+ T-cell percentages decreased significantly (p < 0.02). Lentinan 15-18 interferon gamma Homo sapiens 35-44 11027451-8 2000 When SSc PBMCs activated by anti-CD3 mAb were exposed to thalidomide, increases in both production of IL-2, IL-3, GM-CSF, and IFN-gamma and T cell expression of CD40L were observed. Thalidomide 57-68 interferon gamma Homo sapiens 126-135 11058697-6 2000 Addition of TNFalpha (10 ng/ml) and IFNgamma (20 ng/ml) enhanced the cytotoxicity of oxysterols and potentiated apoptosis. Oxysterols 85-95 interferon gamma Homo sapiens 36-44 11167983-4 2000 Increased IFN-gamma release was observed following in vitro challenge of the patient"s lymphocytes with paracetamol or bromhexine (110% and 157% increase, respectively). Acetaminophen 104-115 interferon gamma Homo sapiens 10-19 11167983-4 2000 Increased IFN-gamma release was observed following in vitro challenge of the patient"s lymphocytes with paracetamol or bromhexine (110% and 157% increase, respectively). Bromhexine 119-129 interferon gamma Homo sapiens 10-19 11069732-15 2000 CONCLUSIONS: These findings suggest that IFN gamma and IL-1 synergistically stimulate the production of IL-6, IL-1ra, NO and PGE(2)and inhibit PG synthesis. Prostaglandins E 125-128 interferon gamma Homo sapiens 41-50 11202234-5 2000 For a subgroup of tuberculin skin test-positive NTM patients we found significantly lower PPD-induced IFN-gamma releases in cultured DWB (P < 0.0002) and PBMC (P < 0.0004) compared to MTb patients. DWB 133-136 interferon gamma Homo sapiens 102-111 11040054-9 2000 Piperlactam S suppressed, in activated T lymphocytes, the production and mRNA expression of cytokines such as interleukin-2 (IL-2), IL-4, and interferon-gamma in a dose-dependent manner. piperlactam S 0-13 interferon gamma Homo sapiens 142-158 11069732-9 2000 NO, IL-6, IL-1ra and PGE(2)production by non-stimulated chondrocytes was dose-dependently increased by IFN gamma while PG production was inhibited. Prostaglandins E 21-24 interferon gamma Homo sapiens 103-112 11035064-7 2000 However, with IFN-gamma present, sCD40L-stimulated PG metabolism is redirected to COX-2, and PGE(2) synthesis increases severalfold. Prostaglandins 51-53 interferon gamma Homo sapiens 14-23 11334244-0 2000 Suppressive effect of TRH and imipramine on human interferon-gamma and interleukin-10 production in vitro. Imipramine 30-40 interferon gamma Homo sapiens 50-66 11334244-4 2000 A significant decrease in the production of IFN-gamma and IL-10 cytokines, by 36% and 34%, respectively, was observed in cells stimulated with mitogens and co-incubated with imipramine and TRH (either given at a dose of 10(-5) M). Imipramine 174-184 interferon gamma Homo sapiens 44-53 11334244-6 2000 Furthermore, imipramine alone decreased, not statistically significantly, though, the production of IFN-gamma. Imipramine 13-23 interferon gamma Homo sapiens 100-109 11334244-7 2000 Hence our data only partly support the above-mentioned hypothesis, since TRH and imipramine applied jointly suppress the production of both the pro-inflammatory IFN-gamma and the anti-inflammatory IL-10 cytokines. Imipramine 81-91 interferon gamma Homo sapiens 161-170 11225250-6 2000 RESULT: Serum TNF alpha or IFN-gamma in RA and RA with ACD patients were higher than those in normal controls, and were inversely correlated with hemoglobin, and serum iron levels. Iron 168-172 interferon gamma Homo sapiens 27-36 11225250-8 2000 TNF alpha and IFN-gamma could specifically inhibit cobalt-induced Epo production in HepG2 cells, and suppressed normal bone marrow BFU-E and CFU-E growth in a dose-dependent manner. Cobalt 51-57 interferon gamma Homo sapiens 14-23 11096449-0 2000 Role of CD28/B7 costimulation in the dexamethasone-induced suppression of IFN-gamma. Dexamethasone 37-50 interferon gamma Homo sapiens 74-83 11096449-7 2000 Lastly, activation of CD28 with anti-CD28 antibody attenuated the Dex-induced decrease in interferon-gamma (IFN-gamma) production by anti-CD3 antibody-stimulated PBMC. Dexamethasone 66-69 interferon gamma Homo sapiens 90-106 11096449-7 2000 Lastly, activation of CD28 with anti-CD28 antibody attenuated the Dex-induced decrease in interferon-gamma (IFN-gamma) production by anti-CD3 antibody-stimulated PBMC. Dexamethasone 66-69 interferon gamma Homo sapiens 108-117 11040335-3 2000 iNOS activity in a cell-free extract of lipopolysaccharide/interferon-gamma-stimulated RAW 264.7 cells was found to be markedly increased, and this increase was prevented by C-1 and C-2, accompanied by the parallel reduction in nitrite accumulation in culture medium. Nitrites 228-235 interferon gamma Homo sapiens 59-75 11035064-7 2000 However, with IFN-gamma present, sCD40L-stimulated PG metabolism is redirected to COX-2, and PGE(2) synthesis increases severalfold. Dinoprostone 93-99 interferon gamma Homo sapiens 14-23 11035064-11 2000 COX-2-mediated PG production impacts MDC function as maturing these cells in the presence of NS-398 yields MDC that stimulate significantly more IFN-gamma in an allogeneic mixed lymphocyte response than MDC matured without this inhibitor. Prostaglandins 15-17 interferon gamma Homo sapiens 145-154 11035064-11 2000 COX-2-mediated PG production impacts MDC function as maturing these cells in the presence of NS-398 yields MDC that stimulate significantly more IFN-gamma in an allogeneic mixed lymphocyte response than MDC matured without this inhibitor. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 93-99 interferon gamma Homo sapiens 145-154 11015296-5 2000 Cells treated with a mixture of IL-1beta, IFNgamma and LPS for 48 h produced a 9 fold increase in PGE(2) and a 3 fold increase in NO levels (both P<0.05). Prostaglandins E 98-101 interferon gamma Homo sapiens 42-50 10998023-16 2000 An increased expression of IFNgamma was detected in bacampicillin treated PBMC cultures from the ACD but not from rhinitis patients. bacampicillin 52-65 interferon gamma Homo sapiens 27-35 11037976-3 2000 In vitro TNF70-80 and recombinant human TNF (hTNF) acted with interferon gamma (IFN-gamma) to reduce bacterial replication and to induce synthesis of bactericidal nitric oxide (NO) in BCG-infected, bone marrow-derived murine macrophages. Nitric Oxide 163-175 interferon gamma Homo sapiens 62-89 11024530-0 2000 Amelioration of CR-EAE with lisofylline: effects on mRNA levels of IL-12 and IFN-gamma in the CNS. lisofylline 28-39 interferon gamma Homo sapiens 77-86 11034119-0 2000 Effect of triclosan on interferon-gamma production and major histocompatibility complex class II expression in human gingival fibroblasts. Triclosan 10-19 interferon gamma Homo sapiens 23-39 11034119-1 2000 BACKGROUND, AIMS: The effect of triclosan (2,4,4"-trichloro-2"-hydroxyl-diphenyl ether) on the production of interferon-gamma (IFN-gamma) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals. Triclosan 32-41 interferon gamma Homo sapiens 109-125 11034119-1 2000 BACKGROUND, AIMS: The effect of triclosan (2,4,4"-trichloro-2"-hydroxyl-diphenyl ether) on the production of interferon-gamma (IFN-gamma) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals. Triclosan 32-41 interferon gamma Homo sapiens 127-136 11034119-1 2000 BACKGROUND, AIMS: The effect of triclosan (2,4,4"-trichloro-2"-hydroxyl-diphenyl ether) on the production of interferon-gamma (IFN-gamma) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals. 2,4,4"-trichloro-2"-hydroxyl-diphenyl ether 43-86 interferon gamma Homo sapiens 109-125 11034119-1 2000 BACKGROUND, AIMS: The effect of triclosan (2,4,4"-trichloro-2"-hydroxyl-diphenyl ether) on the production of interferon-gamma (IFN-gamma) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals. 2,4,4"-trichloro-2"-hydroxyl-diphenyl ether 43-86 interferon gamma Homo sapiens 127-136 11034119-4 2000 Treatment of the cells with triclosan (0.5 microg/ml) reduced both IFN-gamma production and MHC class II expression in human gingival fibroblast cultures. Triclosan 28-37 interferon gamma Homo sapiens 67-76 11034119-5 2000 Similar inhibitory effects on IFN-gamma production and MHC class II expression were observed when the anti-inflammatory agent dexamethazone (1 microM) was used. Dexamethasone 126-139 interferon gamma Homo sapiens 30-39 11031339-8 2000 At the level of MSG protein expression, the 3 cytokines were seen, with a significant increase in IL-4 protein expression in steroid-treated asthmatic subjects compared with untreated asthmatic subjects and control subjects, but there were no differences between the groups in IL-5 and IFN-gamma protein expression. Steroids 125-132 interferon gamma Homo sapiens 286-295 11079780-5 2000 Stimulation of interferon-gamma-treated HBECs with the selective B1 agonist R-838 (Sar [D-Phe8] des Arg9-BK) induced a dose- and time-dependent increase in the production of inositol 3,4,5 tri-phosphate and nitric oxide. r-838 76-81 interferon gamma Homo sapiens 15-31 11079780-5 2000 Stimulation of interferon-gamma-treated HBECs with the selective B1 agonist R-838 (Sar [D-Phe8] des Arg9-BK) induced a dose- and time-dependent increase in the production of inositol 3,4,5 tri-phosphate and nitric oxide. Sarcosine 83-86 interferon gamma Homo sapiens 15-31 11079780-5 2000 Stimulation of interferon-gamma-treated HBECs with the selective B1 agonist R-838 (Sar [D-Phe8] des Arg9-BK) induced a dose- and time-dependent increase in the production of inositol 3,4,5 tri-phosphate and nitric oxide. [d-phe8] des 87-99 interferon gamma Homo sapiens 15-31 11079780-5 2000 Stimulation of interferon-gamma-treated HBECs with the selective B1 agonist R-838 (Sar [D-Phe8] des Arg9-BK) induced a dose- and time-dependent increase in the production of inositol 3,4,5 tri-phosphate and nitric oxide. arg9-bk 100-107 interferon gamma Homo sapiens 15-31 11079780-5 2000 Stimulation of interferon-gamma-treated HBECs with the selective B1 agonist R-838 (Sar [D-Phe8] des Arg9-BK) induced a dose- and time-dependent increase in the production of inositol 3,4,5 tri-phosphate and nitric oxide. inositol 3,4,5-trisphosphate 174-202 interferon gamma Homo sapiens 15-31 11079780-5 2000 Stimulation of interferon-gamma-treated HBECs with the selective B1 agonist R-838 (Sar [D-Phe8] des Arg9-BK) induced a dose- and time-dependent increase in the production of inositol 3,4,5 tri-phosphate and nitric oxide. Nitric Oxide 207-219 interferon gamma Homo sapiens 15-31 11034109-9 2000 However, in U937 cells activated with IFN-gamma, which induces the expression of the RORgamma1 and RORalpha2 nuclear receptors and represses the expression of the mt1 receptor, melatonin can activate IL-6 production. Melatonin 177-186 interferon gamma Homo sapiens 38-47 10973496-5 2000 We find that treatment of cells with the export inhibitor leptomycin B does not affect steady-state localization of Stat1 but impedes nuclear export after IFNgamma-induced nuclear accumulation. leptomycin B 58-70 interferon gamma Homo sapiens 155-163 10975835-6 2000 EMSA using an ICSBP oligonucleotide probe showed that IFN-gamma treatment increased the formation of DNA-binding complex, which was supershifted with anti-IFN regulatory factor-1 Ab and anti-ICSBP Ab. Oligonucleotides 20-35 interferon gamma Homo sapiens 54-63 10975835-8 2000 EMSA using an AP-1-specific oligonucleotide demonstrated that IFN-gamma or LPS treatment increased the AP-1-binding activity. Oligonucleotides 28-43 interferon gamma Homo sapiens 62-71 11082698-16 2000 Immunomodulating effects of GL, GA, and DG derivatives, which induce interferon-gamma and some other cytokines, have been demonstrated in relation with their antiviral activities. Glycyrrhizic Acid 28-30 interferon gamma Homo sapiens 69-85 11082698-16 2000 Immunomodulating effects of GL, GA, and DG derivatives, which induce interferon-gamma and some other cytokines, have been demonstrated in relation with their antiviral activities. Glycyrrhetinic Acid 32-34 interferon gamma Homo sapiens 69-85 11131636-2 2000 The apoptosis inducing effect of interferon-gamma and its modulation by cyclosporin-A or tacrolimus (FK-506) were investigated in in vitro and ex vivo experiments. Tacrolimus 89-99 interferon gamma Homo sapiens 33-49 11022930-0 2000 Association between dinucleotide repeat in non-coding region of interferon-gamma gene and susceptibility to, and severity of, rheumatoid arthritis. Dinucleoside Phosphates 20-32 interferon gamma Homo sapiens 64-80 10947757-5 2000 Before incision, in both groups IL-1beta and IFN-gamma showed a decrease (p<0.01 for IL-1beta in isoflurane group and p<0.05 for the others) compared with pre-induction. Isoflurane 100-110 interferon gamma Homo sapiens 45-54 11131636-2 2000 The apoptosis inducing effect of interferon-gamma and its modulation by cyclosporin-A or tacrolimus (FK-506) were investigated in in vitro and ex vivo experiments. Tacrolimus 101-107 interferon gamma Homo sapiens 33-49 11131636-10 2000 A positive correlation was found between the IFN-gamma level and CsA-induced apoptosis. Cyclosporine 65-68 interferon gamma Homo sapiens 45-54 11131636-11 2000 The CsA-induced apoptosis was also blocked by a specific antibody against human IFN-gamma. Cyclosporine 4-7 interferon gamma Homo sapiens 80-89 11131636-12 2000 These results indicated that both recombinant and endogenous IFN-gamma can induce potent tumor-apoptosis when combined with CsA. Cyclosporine 124-127 interferon gamma Homo sapiens 61-70 11054092-5 2000 In contrast, preincubation of the cells with iron before PMA induction resulted in a decrease of the TNF-alpha secretion induced by IFN-gamma, whereas the opposite was true after preincubation with desferrioxamine. Iron 45-49 interferon gamma Homo sapiens 132-141 10961890-1 2000 Glycosaminoglycans (GAG) are a group of negatively charged molecules that have been shown to bind and directly regulate the bioactivity of growth factors and cytokines such as basic fibroblast growth factor, transforming growth factor-beta, IL-7, and interferon-gamma. Glycosaminoglycans 0-18 interferon gamma Homo sapiens 251-267 10961890-1 2000 Glycosaminoglycans (GAG) are a group of negatively charged molecules that have been shown to bind and directly regulate the bioactivity of growth factors and cytokines such as basic fibroblast growth factor, transforming growth factor-beta, IL-7, and interferon-gamma. Glycosaminoglycans 20-23 interferon gamma Homo sapiens 251-267 11054092-5 2000 In contrast, preincubation of the cells with iron before PMA induction resulted in a decrease of the TNF-alpha secretion induced by IFN-gamma, whereas the opposite was true after preincubation with desferrioxamine. Tetradecanoylphorbol Acetate 57-60 interferon gamma Homo sapiens 132-141 10971511-3 2000 The influence of TA on the expression of ICAM-1 and MHC-I was studied on resting and phorbol myristate acetate (PMA)- or interferon-gamma (IFN-gamma)- and/or tumour necrosis factor-alpha (TNF-alpha)-activated cells using flow cytometry and immunocytochemistry. Triamcinolone Acetonide 17-19 interferon gamma Homo sapiens 139-148 11465083-0 2000 Interferon-gamma-induced tryptophan degradation: neuropsychiatric and immunological consequences. Tryptophan 25-35 interferon gamma Homo sapiens 0-16 11465083-4 2000 IFN-gamma-derived tryptophan degradation may represent an effector mechanism within in the comprehensive network of immune stimulation. Tryptophan 18-28 interferon gamma Homo sapiens 0-9 10988100-7 2000 Budesonide decreased ex vivo generation of IL-5 and IFN-gamma by BAL cells. Budesonide 0-10 interferon gamma Homo sapiens 52-61 10988123-9 2000 IFN-gamma levels were elevated in the wheezers treated with inhaled steroids compared with untreated infants (p = 0.03). Steroids 68-76 interferon gamma Homo sapiens 0-9 10970849-1 2000 The interferon-gamma-induced guanylate-binding protein 1 (GBP1) belongs to a special class of large GTP- binding proteins of 60-100 kDa with unique characteristics. Guanosine Triphosphate 100-103 interferon gamma Homo sapiens 4-20 11022121-0 2000 A short course of oral aspirin increases IL-18-induced interferon-gamma production in whole blood cultures. Aspirin 23-30 interferon gamma Homo sapiens 55-71 11022121-2 2000 Four days after cessation of a 3-day regimen of 650 mg of oral aspirin, there was a 70% increase in interferon-gamma (IFN-gamma) production, stimulated by a combination of interleukin-18 (IL-18) plus lipopolysaccharide (p < 0.05). Aspirin 63-70 interferon gamma Homo sapiens 100-116 11022121-2 2000 Four days after cessation of a 3-day regimen of 650 mg of oral aspirin, there was a 70% increase in interferon-gamma (IFN-gamma) production, stimulated by a combination of interleukin-18 (IL-18) plus lipopolysaccharide (p < 0.05). Aspirin 63-70 interferon gamma Homo sapiens 118-127 11022121-4 2000 TNF-alpha and IFN-gamma production returned to pre-aspirin levels one month after the discontinuation of aspirin. Aspirin 51-58 interferon gamma Homo sapiens 14-23 11028653-7 2000 TY-5 restored IFN-gamma production by blocking CC10 function. ty-5 0-4 interferon gamma Homo sapiens 14-23 10950798-4 2000 Because human immunodeficiency virus (HIV)-infected pregnant women have increased susceptibility to PM, loss of the IFN-gamma response in these women may impair their ability to control PM. pipermethystine 100-102 interferon gamma Homo sapiens 116-125 10950801-3 2000 GBS-stimulated mRNA accumulation and protein secretion of IFN-gamma and interleukin (IL)-12, a major enhancer of IFN-gamma production, by mixed mononuclear cells (MMCs) from umbilical cord and adult peripheral blood was examined. gbs 0-3 interferon gamma Homo sapiens 58-67 10950801-3 2000 GBS-stimulated mRNA accumulation and protein secretion of IFN-gamma and interleukin (IL)-12, a major enhancer of IFN-gamma production, by mixed mononuclear cells (MMCs) from umbilical cord and adult peripheral blood was examined. gbs 0-3 interferon gamma Homo sapiens 113-122 10950801-4 2000 GBS-exposed cord blood MMCs secreted lower concentrations of both IL-12 and IFN-gamma proteins than did MMCs from adults. gbs 0-3 interferon gamma Homo sapiens 76-85 12579638-2 2000 METHOD: Using LipofectAMINE, IFN-gamma gene was transferred in human Tenon"s capsule fibroblasts with plasmid pcDNA3 IFN-gamma. Lipofectamine 14-27 interferon gamma Homo sapiens 29-38 10996034-1 2000 We have isolated the lipoteichoic acid (LTA)-related molecule (OK-PSA) from OK-432, a streptococcal preparation, by an affinity chromatography on CNBr-activated Sepharose 4B-bound TS-2 monoclonal antibody (mAb) that neutralizes interferon (IFN)-gamma-inducing activity of OK-432. lipoteichoic acid 21-38 interferon gamma Homo sapiens 228-250 10996034-1 2000 We have isolated the lipoteichoic acid (LTA)-related molecule (OK-PSA) from OK-432, a streptococcal preparation, by an affinity chromatography on CNBr-activated Sepharose 4B-bound TS-2 monoclonal antibody (mAb) that neutralizes interferon (IFN)-gamma-inducing activity of OK-432. lipoteichoic acid 40-43 interferon gamma Homo sapiens 228-250 10893445-0 2000 Suppressive effects of novel ferulic acid derivatives on cellular responses induced by phorbol ester, and by combined lipopolysaccharide and interferon-gamma. ferulic acid 29-41 interferon gamma Homo sapiens 141-157 11032398-5 2000 Binding of nuclear extracts from RCC cells to an IFN-stimulated response element (ISRE) oligonucleotide probe following incubation with IFN-alpha was not increased by CRA but was significantly increased by pretreatment by IFN-gamma in a time-dependent fashion. Oligonucleotides 88-103 interferon gamma Homo sapiens 222-231 10969179-9 2000 In THP-1 myeloid leukemia cells pretreated with TPA (to induce receptors for IFN-gamma), IFN-gamma induced SOCS-2. Tetradecanoylphorbol Acetate 48-51 interferon gamma Homo sapiens 77-86 10969179-9 2000 In THP-1 myeloid leukemia cells pretreated with TPA (to induce receptors for IFN-gamma), IFN-gamma induced SOCS-2. Tetradecanoylphorbol Acetate 48-51 interferon gamma Homo sapiens 89-98 10972213-9 2000 Recombinant porcine interferon-gamma weakly stimulated ICAM-1 expression when incubated alone with PAEC but had an inhibitory effect on the increase in ICAM-1 due to TNF-alpha, both at 8 and 24 hr. paec 99-103 interferon gamma Homo sapiens 20-36 10964663-1 2000 In vitro, interferon-gamma stimulates primate monocytes/macrophages to produce the pteridines neopterin and 7,8-dihydroneopterin. Pteridines 83-93 interferon gamma Homo sapiens 10-26 10964663-1 2000 In vitro, interferon-gamma stimulates primate monocytes/macrophages to produce the pteridines neopterin and 7,8-dihydroneopterin. Neopterin 94-103 interferon gamma Homo sapiens 10-26 10964663-1 2000 In vitro, interferon-gamma stimulates primate monocytes/macrophages to produce the pteridines neopterin and 7,8-dihydroneopterin. 7,8-dihydroneopterin 108-128 interferon gamma Homo sapiens 10-26 12579638-2 2000 METHOD: Using LipofectAMINE, IFN-gamma gene was transferred in human Tenon"s capsule fibroblasts with plasmid pcDNA3 IFN-gamma. Lipofectamine 14-27 interferon gamma Homo sapiens 117-126 10952721-8 2000 IL-12-induced IFN-gamma production in IL-12Rbeta1-deficient T cells could be inhibited by the p38 mitogen-activated protein kinase (MAP) kinase inhibitor SB203580 and the MAP kinase kinase (MEK) 1/2 inhibitor U0126, suggesting involvement of MAP kinases in this alternative, Stat4-independent, IL-12 signaling pathway.Collectively, these results indicate that IL-12 acts as a partial agonist in the absence of IL-12Rbeta1. SB 203580 154-162 interferon gamma Homo sapiens 14-23 10952721-8 2000 IL-12-induced IFN-gamma production in IL-12Rbeta1-deficient T cells could be inhibited by the p38 mitogen-activated protein kinase (MAP) kinase inhibitor SB203580 and the MAP kinase kinase (MEK) 1/2 inhibitor U0126, suggesting involvement of MAP kinases in this alternative, Stat4-independent, IL-12 signaling pathway.Collectively, these results indicate that IL-12 acts as a partial agonist in the absence of IL-12Rbeta1. U 0126 209-214 interferon gamma Homo sapiens 14-23 10925318-9 2000 A strong correlation was noted between tHLA staining of postvaccination PBMC and IFN-gamma expression by the same samples upon vaccine-relevant stimulation and assessed either by IC-FACS or qRT-PCR. thla 39-43 interferon gamma Homo sapiens 81-90 11039878-3 2000 In this study, we focused on interferon-gamma (IFN-gamma) and IgA production by tonsillar mononuclear cells (TMC) in patients with IgAN. tmc 109-112 interferon gamma Homo sapiens 29-45 11039878-5 2000 The induction of IFN-gamma and IgA in vitro by TMC from IgAN patients was compared with that from CT patients. tmc 47-50 interferon gamma Homo sapiens 17-26 11028755-8 2000 CONCLUSIONS: Since previously the inhibitory effect of histamine on gene expression of interferon gamma was detected, a reciprocal inhibition between histamine and IFNgamma is proposed. Histamine 55-64 interferon gamma Homo sapiens 87-103 10940934-4 2000 HEL injection with incomplete Freund"s adjuvant (IFA) resulted in an IFN-gamma(-)/IL-5(+) Th2 recall response. incomplete Freund's adjuvant 49-52 interferon gamma Homo sapiens 69-78 11028755-8 2000 CONCLUSIONS: Since previously the inhibitory effect of histamine on gene expression of interferon gamma was detected, a reciprocal inhibition between histamine and IFNgamma is proposed. Histamine 55-64 interferon gamma Homo sapiens 164-172 10992047-2 2000 In this assay, IFN-gamma can be detected by simply adding a mixture of three reagents-biotinylated polyclonal antibody, europium cryptate (fluorescence donor, EuK)-labeled monoclonal antibody, and crosslinked allophycocyanin (fluorescence acceptor, XL665) conjugated with streptavidin-and then measuring the time-resolved fluorescence. Crown Ethers 129-137 interferon gamma Homo sapiens 15-24 10932071-7 2000 Nicotine, at a concentration comparable with that found in the highest-tar cigarettes (200 microg/mL), suppressed the production of IL-2, IFN-gamma, and TNF-alpha by only 21% to 38%. Nicotine 0-8 interferon gamma Homo sapiens 138-147 10932071-9 2000 In contrast, hydroquinone inhibited the production of all 4 cytokines with IC(50) values ranging from 3 micromol/L(IL-1beta) to 29 micromol/L (IFN-gamma). hydroquinone 13-25 interferon gamma Homo sapiens 143-152 10903743-5 2000 Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3. Nickel 0-6 interferon gamma Homo sapiens 78-87 10900040-7 2000 Culture supernatants of PB T cells stimulated with recombinant gH(t(His)):gL contained high levels of interferon-gamma and no detectable interleukin-4, indicating their Th1 phenotype. glycylleucine 74-76 interferon gamma Homo sapiens 102-118 11023273-5 2000 GMC, as obtained from patients" tissues, expressed IL-2, IFN-gamma, or IL-5 mRNA. Puromycin aminonucleoside 0-3 interferon gamma Homo sapiens 57-66 10900354-6 2000 The mean levels of interferon (IFN) gamma secretion and the mean ratio of IFN-gamma/IL-5 were lower for GA-reactive cell lines, derived from patients both prior to and during GA therapy, compared to MBP-reactive T cell lines. Glatiramer Acetate 104-106 interferon gamma Homo sapiens 19-41 10900354-6 2000 The mean levels of interferon (IFN) gamma secretion and the mean ratio of IFN-gamma/IL-5 were lower for GA-reactive cell lines, derived from patients both prior to and during GA therapy, compared to MBP-reactive T cell lines. Glatiramer Acetate 104-106 interferon gamma Homo sapiens 74-83 10900354-7 2000 The proportion of IFN-gamma(+) cells in unfractionated lymphocyte preparations derived from the GA-treated patients did not differ from that found for healthy controls. Glatiramer Acetate 96-98 interferon gamma Homo sapiens 18-27 10887096-5 2000 Pamidronate-activated gamma delta T cells produced cytokines (ie, interferon [IFN]-gamma) and exhibited specific cytotoxicity against lymphoma (Daudi) and myeloma cell lines (RPMI 8226, U266). Pamidronate 0-11 interferon gamma Homo sapiens 78-88 10887204-7 2000 Co-culture of the SK-N-MC cells with interferon-gamma and lipopolysaccharide-activated macrophages, which release NO, also reduced the DbetaH activity in the neuroblastoma cells. sk-n-mc 18-25 interferon gamma Homo sapiens 37-53 11006006-1 2000 IL-2-activated killer lymphocytes (LAK cells) secrete inflammatory cytokines such as interferon-gamma (IFN-gamma) and tumor necrosis factor alpha (TNFalpha) that can induce nitric oxide (NO) synthesis. Nitric Oxide 173-185 interferon gamma Homo sapiens 85-101 11006006-1 2000 IL-2-activated killer lymphocytes (LAK cells) secrete inflammatory cytokines such as interferon-gamma (IFN-gamma) and tumor necrosis factor alpha (TNFalpha) that can induce nitric oxide (NO) synthesis. Nitric Oxide 173-185 interferon gamma Homo sapiens 103-112 10908724-1 2000 In a search for new inhibitors of the IFN-gamma mediated signal transduction in HeLa S3 cells using secreted alkaline phosphatase (SEAP) as reporter gene, the novel pyran-dione trichodion was isolated from fermentations of the imperfect fungus Trichosporiella sp. pyran-dione 165-176 interferon gamma Homo sapiens 38-47 10855665-5 2000 Competitive RT-PCR analysis of IFN-gamma mRNA expression revealed that peripheral blood mononuclear cells (PBMC) of animals with PL+ status developed by 4 weeks after infection had augmented IFN-gamma mRNA expression 3-4 weeks after BLV infection. pl+ 129-132 interferon gamma Homo sapiens 31-40 10902767-6 2000 RESULTS: Bucillamine (64 microM) significantly inhibited T cell proliferation and the production of IL-2, IFNgamma, TNFalpha, and IL-6, whereas it had no inhibitory effects on the production of IL-4 and IL-5 in the cultures with anti-CD3 plus anti-CD26 mAb. bucillamine 9-20 interferon gamma Homo sapiens 106-114 11002391-5 2000 Phenotyping of U937 cells for complement receptors (CRs) and Fcgamma receptors (FcgammaRs) showed that interferon gamma (INFgamma) increased expression of FcgammaRI, CR3 (CD11b/CD18) and CR4 (CD11c/CD18) and that phorbol-12-myristate-13-acetate (PMA) increased expression of CR4. Tetradecanoylphorbol Acetate 213-244 interferon gamma Homo sapiens 103-130 10858219-1 2000 Beryllium is associated with a human pulmonary granulomatosis characterized by an accumulation of CD4(+) T cells in the lungs and a heightened specific lymphocyte proliferative response to beryllium (Be) with gamma interferon (IFN-gamma) release (i.e., a T helper 1 [Th1] response). Beryllium 0-9 interferon gamma Homo sapiens 209-236 10858219-1 2000 Beryllium is associated with a human pulmonary granulomatosis characterized by an accumulation of CD4(+) T cells in the lungs and a heightened specific lymphocyte proliferative response to beryllium (Be) with gamma interferon (IFN-gamma) release (i.e., a T helper 1 [Th1] response). Beryllium 189-198 interferon gamma Homo sapiens 209-236 10966061-0 2000 Effect of interferon-gamma on experimental scleroderma induced by bleomycin. Bleomycin 66-75 interferon gamma Homo sapiens 10-26 10929062-1 2000 This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA-S) and the number of human peripheral blood cells actively secreting interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma) in vivo. Dehydroepiandrosterone Sulfate 87-118 interferon gamma Homo sapiens 277-293 10929062-1 2000 This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA-S) and the number of human peripheral blood cells actively secreting interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma) in vivo. Dehydroepiandrosterone Sulfate 87-118 interferon gamma Homo sapiens 295-304 10855665-5 2000 Competitive RT-PCR analysis of IFN-gamma mRNA expression revealed that peripheral blood mononuclear cells (PBMC) of animals with PL+ status developed by 4 weeks after infection had augmented IFN-gamma mRNA expression 3-4 weeks after BLV infection. pl+ 129-132 interferon gamma Homo sapiens 191-200 10926204-1 2000 We have previously reported the isolation of mutant cell lines from the human carcinoma line ME180 that are resistant to the antiproliferative effect of interferon-gamma (IFN-gamma). me180 93-98 interferon gamma Homo sapiens 153-169 10861056-7 2000 Ex vivo splenocyte proliferative and CTL responses and Th1 cytokine (IFN-gamma) production in response to donor alloantigens were augmented by FL-BM infusion, but reduced by tacrolimus. fl-bm 143-148 interferon gamma Homo sapiens 69-78 10926204-1 2000 We have previously reported the isolation of mutant cell lines from the human carcinoma line ME180 that are resistant to the antiproliferative effect of interferon-gamma (IFN-gamma). me180 93-98 interferon gamma Homo sapiens 171-180 10926207-0 2000 IFN-gamma enhances osteoclast generation in cultures of peripheral blood from osteopetrotic patients and normalizes superoxide production. Superoxides 116-126 interferon gamma Homo sapiens 0-9 10926207-10 2000 IFN-gamma markedly increased (p < 0.0001) superoxide production. Superoxides 45-55 interferon gamma Homo sapiens 0-9 10871651-4 2000 IFN-gamma and increasing doses of TNF-alpha resulted in decreasing viability of trophoblast on uncoated as well as fibronectin-coated dishes, as shown by 3-[4, 5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assays, but for each TNF/IFN treatment condition viability on fibronectin was higher (P < 0.001). thiazolyl blue 154-216 interferon gamma Homo sapiens 0-9 11007161-8 2000 Both IFN-gamma dependent and -independent cytotoxicity were partially blocked either by anti-tumor necrosis factor-alpha (TNF-alpha) antibody or by the inhibitor of nitric oxide synthesis. Nitric Oxide 165-177 interferon gamma Homo sapiens 5-14 11007162-4 2000 RESULTS: Activation of lymphocytes with PMA + Ionomycin induced the expression of IL-2 and IFN-gamma in each lymphocyte population. Tetradecanoylphorbol Acetate 40-43 interferon gamma Homo sapiens 91-100 11007162-4 2000 RESULTS: Activation of lymphocytes with PMA + Ionomycin induced the expression of IL-2 and IFN-gamma in each lymphocyte population. Ionomycin 46-55 interferon gamma Homo sapiens 91-100 10912884-10 2000 The prevention of the lowering of plasma glutamine concentration allows an increased response of lymphocytes to ConA and LPS, as well as an increased production of IL-1 and 2, TNF-alpha, and IFN-gamma, possibly linked to the lower incidence of symptoms of infection (33.84%) reported by the supplemented athletes. Glutamine 41-50 interferon gamma Homo sapiens 191-200 10766757-0 2000 Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines. Tyrosine 0-8 interferon gamma Homo sapiens 95-111 10766757-5 2000 In these studies, we demonstrate that interferon gamma (IFN-gamma)-induced differentiation of myeloid cell lines abolishes in vitro Pbx-HoxA10 binding to either the derived consensus or the similar CYBB sequence. 4-Bromobenzene-1,2,3-triol 132-135 interferon gamma Homo sapiens 38-65 10766757-8 2000 However, IFN-gamma-induced differentiation of myeloid cell lines leads to HoxA10 tyrosine phosphorylation, which decreases in vitro DNA binding to Pbx-HoxA10 binding sites. Tyrosine 81-89 interferon gamma Homo sapiens 9-18 10766757-8 2000 However, IFN-gamma-induced differentiation of myeloid cell lines leads to HoxA10 tyrosine phosphorylation, which decreases in vitro DNA binding to Pbx-HoxA10 binding sites. 4-Bromobenzene-1,2,3-triol 147-150 interferon gamma Homo sapiens 9-18 10840457-14 2000 CONCLUSIONS: Losartan is associated with downregulation of TGF-beta, IFN-gamma and IL-6 and may, in combination with antimicrobial therapy, reduce the risk of cortical renal scarring in recurrent acute pyelonephritis in infants. Losartan 13-21 interferon gamma Homo sapiens 69-78 10848598-6 2000 In addition, glutathione S-transferase fusion genes encoding normal FANCC but not a mutant FANCC bearing an inactivating point mutation (L554P) bound to STAT1 in lysates of IFN-gamma-stimulated B cells and IFN-, granulocyte-macrophage colony-stimulating factor- and stem cell factor-stimulated MO7e cells. Glutathione 13-24 interferon gamma Homo sapiens 173-182 10871651-4 2000 IFN-gamma and increasing doses of TNF-alpha resulted in decreasing viability of trophoblast on uncoated as well as fibronectin-coated dishes, as shown by 3-[4, 5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assays, but for each TNF/IFN treatment condition viability on fibronectin was higher (P < 0.001). monooxyethylene trimethylolpropane tristearate 218-221 interferon gamma Homo sapiens 0-9 10861011-5 2000 We used intracellular double-immunofluorescence flow cytometry for quantitative analysis of cytokine production (IL-4, IFN-gamma) by the TCL. Triclosan 137-140 interferon gamma Homo sapiens 119-128 10869889-0 2000 Effects of serotonin and serotonergic agonists and antagonists on the production of interferon-gamma and interleukin-10. Serotonin 11-20 interferon gamma Homo sapiens 84-100 10861011-6 2000 The majority of the COP-reactive TCL from untreated multiple sclerosis patients and normal donors predominantly produced IFN-gamma and, accordingly, were classified as T helper 1 cells (TH1). Triclosan 33-36 interferon gamma Homo sapiens 121-130 10861011-9 2000 Interestingly, although there was no proliferative cross-reaction, about 10% of the COP-reactive TCL responded to MBP by secretion of small amounts of IL-4 or IFN-gamma, depending on the cytokine profile of the TCL. Triclosan 97-100 interferon gamma Homo sapiens 159-168 10866311-0 2000 Regrowth of 5-fluorouracil-treated human colon cancer cells is prevented by the combination of interferon gamma, indomethacin, and phenylbutyrate. Fluorouracil 12-26 interferon gamma Homo sapiens 95-111 10866323-9 2000 However, demethylation at SIE-1, induced by a demethylating agent 5-aza-2"-deoxycytidine, reactivated p21WAF1 expression and restored the responsiveness to IFN-gamma in RD cells. Decitabine 66-88 interferon gamma Homo sapiens 156-165 10843724-0 2000 Histamine is a potent inducer of IL-18 and IFN-gamma in human peripheral blood mononuclear cells. Histamine 0-9 interferon gamma Homo sapiens 43-52 10843724-1 2000 Histamine (10-7 to 10-4 M) concentration-dependently stimulated the production of IL-18 and IFN-gamma and inhibited the production of IL-2 and IL-10 in human PBMCs. Histamine 0-9 interferon gamma Homo sapiens 92-101 10843724-9 2000 IFN-gamma production induced by IL-18 was inhibited by anti-IL-12 Ab, showing the marked contrast of the effect of histamine. Histamine 115-124 interferon gamma Homo sapiens 0-9 10828042-3 2000 The patients" phagocytes have been shown previously to greatly increase superoxide release in response to interferon-gamma (IFN-gamma) in vitro and in vivo. Superoxides 72-82 interferon gamma Homo sapiens 106-122 10860828-4 2000 The present study was designed to elucidate sequentially the action mechanisms of acetaminophen and salicylates (aspirin and sodium salicylate) on lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma)-induced iNOS expression in RAW 264.7 macrophages. Acetaminophen 82-95 interferon gamma Homo sapiens 177-204 10860828-4 2000 The present study was designed to elucidate sequentially the action mechanisms of acetaminophen and salicylates (aspirin and sodium salicylate) on lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma)-induced iNOS expression in RAW 264.7 macrophages. Salicylates 100-111 interferon gamma Homo sapiens 177-204 10860828-4 2000 The present study was designed to elucidate sequentially the action mechanisms of acetaminophen and salicylates (aspirin and sodium salicylate) on lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma)-induced iNOS expression in RAW 264.7 macrophages. Aspirin 113-120 interferon gamma Homo sapiens 177-204 10860828-4 2000 The present study was designed to elucidate sequentially the action mechanisms of acetaminophen and salicylates (aspirin and sodium salicylate) on lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma)-induced iNOS expression in RAW 264.7 macrophages. Sodium Salicylate 125-142 interferon gamma Homo sapiens 177-204 10860828-10 2000 These findings suggest that acetaminophen may exert analgesic or anti-inflammatory effect by inhibiting iNOS expression induced by LPS plus IFN-gamma at transcriptional level by suppression of NF-kappaB binding activity, whereas salicylates exert its effect by inhibiting iNOS expression at the translational or posttranslational level. Acetaminophen 28-41 interferon gamma Homo sapiens 140-149 10828042-3 2000 The patients" phagocytes have been shown previously to greatly increase superoxide release in response to interferon-gamma (IFN-gamma) in vitro and in vivo. Superoxides 72-82 interferon gamma Homo sapiens 124-133 10843735-0 2000 Interferon-gamma and interleukin 4 inhibit interleukin 1beta-induced delayed prostaglandin E(2)generation through suppression of cyclooxygenase-2 expression in human fibroblasts. Prostaglandins E 77-92 interferon gamma Homo sapiens 0-16 10843764-6 2000 IFN-gamma also synergistically augmented HGF production induced by interleukin-1beta and cAMP-increasing agents cholera toxin, forskolin and prostaglandin E(2). Colforsin 127-136 interferon gamma Homo sapiens 0-9 10843735-6 2000 IFN-gamma and IL-4 dramatically inhibited the IL-1beta-induced delayed PGE(2)generation; these cytokines apparently suppressed IL-1beta-stimulated COX-2 expression and only weakly suppressed cPLA(2)expression in response to IL-1beta. Prostaglandins E 71-74 interferon gamma Homo sapiens 0-9 10843764-6 2000 IFN-gamma also synergistically augmented HGF production induced by interleukin-1beta and cAMP-increasing agents cholera toxin, forskolin and prostaglandin E(2). Prostaglandins E 141-156 interferon gamma Homo sapiens 0-9 10843750-4 2000 We found that cell surface heparan sulfate, which binds IFN-gamma, delayed the nuclear accumulation of IFN-gamma suggesting that these molecules serve as storage depot around the cell for local delivery of the cytokine. Heparitin Sulfate 27-42 interferon gamma Homo sapiens 56-65 10843750-4 2000 We found that cell surface heparan sulfate, which binds IFN-gamma, delayed the nuclear accumulation of IFN-gamma suggesting that these molecules serve as storage depot around the cell for local delivery of the cytokine. Heparitin Sulfate 27-42 interferon gamma Homo sapiens 103-112 10843764-8 2000 The synergy between HGF inducers and IFN-gamma is not common to all HGF inducers, because HGF production stimulated by epidermal growth factor and protein-kinase-C-activating phorbol esters was significantly inhibited by IFN-gamma. Phorbol Esters 175-189 interferon gamma Homo sapiens 37-46 10843764-8 2000 The synergy between HGF inducers and IFN-gamma is not common to all HGF inducers, because HGF production stimulated by epidermal growth factor and protein-kinase-C-activating phorbol esters was significantly inhibited by IFN-gamma. Phorbol Esters 175-189 interferon gamma Homo sapiens 221-230 10907120-6 2000 Production of IFN-gamma seen in high-risk relatives was negatively correlated to production of GADA (r = -0.44, p = 0.05). gada 95-99 interferon gamma Homo sapiens 14-23 10799875-0 2000 Monophosphoryl lipid A and QS21 increase CD8 T lymphocyte cytotoxicity to herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 production. monophosphoryl 0-14 interferon gamma Homo sapiens 137-146 10835324-3 2000 The cystic fibrosis transmembrane conductance regulator was also downregulated by interferon-gamma as evident at the protein level and by the decrease in the cAMP-dependent current. Cyclic AMP 158-162 interferon gamma Homo sapiens 82-98 10835324-4 2000 On the other hand, interferon-gamma caused an increase of the current elicited by apical UTP application, which is due to the activity of Ca(2+)-dependent Cl(-) channels. Uridine Triphosphate 89-92 interferon gamma Homo sapiens 19-35 10835324-7 2000 At rest, both types of cells showed an amiloride-sensitive fluid absorption that was inhibited by interferon-gamma but not by tumor necrosis factor-alpha. Amiloride 39-48 interferon gamma Homo sapiens 98-114 10820436-8 2000 In contrast, monocyte adhesion to IL-1alpha or IFNgamma treated SK-N-MC was only slightly inhibited with a combination of mAb to CD18 + VLA-4 and there was no inhibition at all to TNFalpha-treated SK-N-MC. sk-n-mc 64-71 interferon gamma Homo sapiens 47-55 10820436-8 2000 In contrast, monocyte adhesion to IL-1alpha or IFNgamma treated SK-N-MC was only slightly inhibited with a combination of mAb to CD18 + VLA-4 and there was no inhibition at all to TNFalpha-treated SK-N-MC. sk-n-mc 197-204 interferon gamma Homo sapiens 47-55 10935448-5 2000 In contrast, beta-catenin protein levels were reduced markedly in NTera2-N cells by exposure to dbcAMP, EGF or bFGF, and in U-373MG cells by treatment with dbcAMP or PMA, but were unaffected in any cell lines by BDNF, TNF-alpha, IL-1beta, IL-6, IFN-gamma or TGF-beta1. Bucladesine 156-162 interferon gamma Homo sapiens 245-254 10872819-4 2000 Ovalbumin-dependent production of immunoglobulins IgE, IgG1 and interleukin IL-4 was suppressed by administration of medication doses of pyridoxal (PA) or pyridoxine (PI), while the production of IgG2alpha and interferon (INF)-gamma mediated by helper T lymphocyte type 1 was not changed. Pyridoxal 137-146 interferon gamma Homo sapiens 210-232 10872819-4 2000 Ovalbumin-dependent production of immunoglobulins IgE, IgG1 and interleukin IL-4 was suppressed by administration of medication doses of pyridoxal (PA) or pyridoxine (PI), while the production of IgG2alpha and interferon (INF)-gamma mediated by helper T lymphocyte type 1 was not changed. Pyridoxal 148-150 interferon gamma Homo sapiens 210-232 10883730-5 2000 There was, however, an inhibition of IFN-gamma and TNF-alpha production by simazine, metoxuron and mecoprop and of all three cytokines tested by diuron. Simazine 75-83 interferon gamma Homo sapiens 37-46 10883730-5 2000 There was, however, an inhibition of IFN-gamma and TNF-alpha production by simazine, metoxuron and mecoprop and of all three cytokines tested by diuron. 3-(3-chloro-4-methoxyphenyl)-1,1-dimethylurea 85-94 interferon gamma Homo sapiens 37-46 10799875-0 2000 Monophosphoryl lipid A and QS21 increase CD8 T lymphocyte cytotoxicity to herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 production. Lipid A 15-22 interferon gamma Homo sapiens 137-146 10788433-3 2000 In C6 glioma cells, tumor necrosis factor-alpha (TNF-alpha) concomitantly potentiated the stimulation of nitric oxide (NO) and BH(4) production induced by IFN-gamma and interleukin-1beta. Nitric Oxide 105-117 interferon gamma Homo sapiens 155-164 10860730-2 2000 IFN-gamma SC1 was derived by linking the two peptide chains of the IFN-gamma dimer by a seven-residue linker and changing His111 in the first chain to an aspartic acid residue. Aspartic Acid 154-167 interferon gamma Homo sapiens 0-9 10860730-4 2000 The crystal structure of IFN-gamma SC1 has been determined at 2.9 A resolution from crystals grown in 1.4 M citrate solutions at pH 7.6. Citric Acid 108-115 interferon gamma Homo sapiens 25-34 10860730-6 2000 As a result, surface charge rather than structural changes is likely responsible for the inability of the His111-->Asp domain of to bind IFN-gamma R alpha. Aspartic Acid 118-121 interferon gamma Homo sapiens 140-149 10954204-5 2000 The other difference was an increased interferon-gamma staining of infiltrating mononuclear inflammatory cells in the dermis in the sodium lauryl sulphate group compared with the nickel group. Sodium Dodecyl Sulfate 132-154 interferon gamma Homo sapiens 38-54 11324436-0 2000 Antagonism of LPS and IFN-gamma induced iNOS expression in human atrial endothelia by morphine, anandamide, and estrogen. Morphine 86-94 interferon gamma Homo sapiens 22-31 11324436-0 2000 Antagonism of LPS and IFN-gamma induced iNOS expression in human atrial endothelia by morphine, anandamide, and estrogen. anandamide 96-106 interferon gamma Homo sapiens 22-31 11324436-5 2000 The nitric oxide donor SNAP also blocked iNOS induction while preincubation of atrial fragments with an inhibitor of NOS, L-NAME, prior to morphine or anandamide exposure, restored LPS + IFN-gamma induction of iNOS. Nitric Oxide 4-16 interferon gamma Homo sapiens 187-196 11324436-5 2000 The nitric oxide donor SNAP also blocked iNOS induction while preincubation of atrial fragments with an inhibitor of NOS, L-NAME, prior to morphine or anandamide exposure, restored LPS + IFN-gamma induction of iNOS. NG-Nitroarginine Methyl Ester 122-128 interferon gamma Homo sapiens 187-196 11324436-5 2000 The nitric oxide donor SNAP also blocked iNOS induction while preincubation of atrial fragments with an inhibitor of NOS, L-NAME, prior to morphine or anandamide exposure, restored LPS + IFN-gamma induction of iNOS. anandamide 151-161 interferon gamma Homo sapiens 187-196 10788422-5 2000 Here we show that 16K-PRL, but not full-length PRL, acts to promote the expression of the inducible isoform of nitric oxide synthase (iNOS) and nitric oxide (*NO) production by pulmonary fibroblasts and alveolar type II cells with potency comparable with the proinflammatory cytokines interleukin-1beta, interferon gamma, and tumor necrosis factor alpha. Nitric Oxide 111-123 interferon gamma Homo sapiens 304-353 10823661-5 2000 Furthermore, since the stability of N-glycosylated proteins is known to be regulated by lectin family chaperones, such as calnexin, a type I transmembrane protein located in the endoplasmic reticulum (ER), and calreticulin, a soluble protein in the ER lumen, the effect of the processing inhibitors on the interaction of IFN-gamma with calnexin and calreticulin was investigated. Nitrogen 36-37 interferon gamma Homo sapiens 321-330 10828862-4 2000 Although T cell proliferative and cytokine (IFN-gamma and IL-4) responses to alloantigen stimulation and Con A were significantly reduced in post-G-CSF NAC, they were restored by the removal of non-T cells from post-G-CSF NAC. nac 152-155 interferon gamma Homo sapiens 44-53 10857760-0 2000 Glycosaminoglycans alter the conformation of interferon-gamma. Glycosaminoglycans 0-18 interferon gamma Homo sapiens 45-61 10848831-9 2000 All NADPH oxidase subunits were constitutively present, but nitroblue tetrazolium reduction was only detectable upon activation with IFN-gamma. Nitroblue Tetrazolium 60-81 interferon gamma Homo sapiens 133-142 10792372-0 2000 The antagonism of interferon-gamma (IFN-gamma) by heparin: examination of the blockade of class II MHC antigen and heat shock protein-70 expression. Heparin 50-57 interferon gamma Homo sapiens 18-34 10792372-0 2000 The antagonism of interferon-gamma (IFN-gamma) by heparin: examination of the blockade of class II MHC antigen and heat shock protein-70 expression. Heparin 50-57 interferon gamma Homo sapiens 36-45 10792372-4 2000 It is known that IFN-gamma can bind cell surface and extracellular heparan sulphate. Heparitin Sulfate 67-83 interferon gamma Homo sapiens 17-26 10792372-6 2000 In this study it is shown that heparin can prevent normal induction of the class II transactivator and heat shock cognate protein-70 in an IFN-gamma-treated endothelial cell line. Heparin 31-38 interferon gamma Homo sapiens 139-148 10792372-8 2000 This provides further evidence for the blockade by heparin of ligand activation of the specific IFN-gamma receptor. Heparin 51-58 interferon gamma Homo sapiens 96-105 10792375-3 2000 Upon cell activation by phorbol myristate acetate and ionomycin, the proportion of CD4+ T cells containing interferon-gamma (IFN-gamma) was found to be greater in the old subjects. Tetradecanoylphorbol Acetate 24-49 interferon gamma Homo sapiens 107-123 10792375-3 2000 Upon cell activation by phorbol myristate acetate and ionomycin, the proportion of CD4+ T cells containing interferon-gamma (IFN-gamma) was found to be greater in the old subjects. Tetradecanoylphorbol Acetate 24-49 interferon gamma Homo sapiens 125-134 10792375-3 2000 Upon cell activation by phorbol myristate acetate and ionomycin, the proportion of CD4+ T cells containing interferon-gamma (IFN-gamma) was found to be greater in the old subjects. Ionomycin 54-63 interferon gamma Homo sapiens 107-123 10792375-3 2000 Upon cell activation by phorbol myristate acetate and ionomycin, the proportion of CD4+ T cells containing interferon-gamma (IFN-gamma) was found to be greater in the old subjects. Ionomycin 54-63 interferon gamma Homo sapiens 125-134 10808178-6 2000 Although the majority of lymphocytes remained in the peritoneum, significant numbers of T lymphocytes were located in the spleen, where human IL-4, IL-5, and IFN-gamma messenger RNA expression was detected after stimulation with PHA and phorbol myristate acetate. Tetradecanoylphorbol Acetate 237-262 interferon gamma Homo sapiens 158-167 10899704-4 2000 However, in U937 cells activated with IFN-gamma, which induces the expression of the ROR alpha 1 and ROR alpha 2 nuclear receptors and represses the expression of the mt1 receptor, melatonin can activate IL-6 production. Melatonin 181-190 interferon gamma Homo sapiens 38-47 10841949-1 2000 Histamine, an important inflammatory mediator in allergic diseases and asthma, was reported to have modulatory effects on T cells by down-regulating Th1-type cell cytokines like interleukin 2 (IL-2) and interferon-gamma (IFN-gamma). Histamine 0-9 interferon gamma Homo sapiens 203-219 10841949-1 2000 Histamine, an important inflammatory mediator in allergic diseases and asthma, was reported to have modulatory effects on T cells by down-regulating Th1-type cell cytokines like interleukin 2 (IL-2) and interferon-gamma (IFN-gamma). Histamine 0-9 interferon gamma Homo sapiens 221-230 10841949-2 2000 In this study we examined the effect of histamine and the histamine-receptor antagonists cimetidine and diphenhydramine on the production of neopterin after stimulation with IFN-gamma in the myelomonocytoma cell line THP-1. Histamine 40-49 interferon gamma Homo sapiens 174-183 10841949-2 2000 In this study we examined the effect of histamine and the histamine-receptor antagonists cimetidine and diphenhydramine on the production of neopterin after stimulation with IFN-gamma in the myelomonocytoma cell line THP-1. Cimetidine 89-99 interferon gamma Homo sapiens 174-183 10841949-2 2000 In this study we examined the effect of histamine and the histamine-receptor antagonists cimetidine and diphenhydramine on the production of neopterin after stimulation with IFN-gamma in the myelomonocytoma cell line THP-1. Diphenhydramine 104-119 interferon gamma Homo sapiens 174-183 10841949-2 2000 In this study we examined the effect of histamine and the histamine-receptor antagonists cimetidine and diphenhydramine on the production of neopterin after stimulation with IFN-gamma in the myelomonocytoma cell line THP-1. Neopterin 141-150 interferon gamma Homo sapiens 174-183 10841949-3 2000 Increasing concentrations of histamine markedly suppressed IFN-gamma induced neopterin formation. Histamine 29-38 interferon gamma Homo sapiens 59-68 10841949-3 2000 Increasing concentrations of histamine markedly suppressed IFN-gamma induced neopterin formation. Neopterin 77-86 interferon gamma Homo sapiens 59-68 10841949-4 2000 Simultaneous preincubation of THP-1 cells with histamine, IFN-gamma and different concentrations of the H(2)-receptor antagonist cimetidine showed a clear antagonizing effect on neopterin formation. Neopterin 178-187 interferon gamma Homo sapiens 58-67 10841949-6 2000 Our results suggest, that histamine may be a potent inhibitor of effects or mechanisms induced by IFN-gamma in monocytes/macrophages. Histamine 26-35 interferon gamma Homo sapiens 98-107 10823758-4 2000 CBMC IL-12 levels were increased by interferon-gamma and CD40 ligand but remained deficient, compared with PBMC. cbmc 0-4 interferon gamma Homo sapiens 36-52 10841074-7 2000 Analogous to treatment of virus-infected cells, suboptimal concentrations of ACV were as effective as high concentrations when used in conjunction with low concentrations of IFN-gamma in inhibition of tumor cell growth. Acyclovir 77-80 interferon gamma Homo sapiens 174-183 10841074-9 2000 The cooperative effect of ACV and IFN-gamma against the glioblastomas appears to be due to direct inhibition of DNA synthesis by ACV in the S phase of the cell cycle and induction by IFN-gamma of the tumor suppressor gene p21wAF1/CIP1, which in turn acts at the level of proliferating cell nuclear antigen (PCNA) and cyclin E/cyclin-dependent kinase 2 (Cdk2) binding and inhibition of function. Acyclovir 26-29 interferon gamma Homo sapiens 183-192 10841074-9 2000 The cooperative effect of ACV and IFN-gamma against the glioblastomas appears to be due to direct inhibition of DNA synthesis by ACV in the S phase of the cell cycle and induction by IFN-gamma of the tumor suppressor gene p21wAF1/CIP1, which in turn acts at the level of proliferating cell nuclear antigen (PCNA) and cyclin E/cyclin-dependent kinase 2 (Cdk2) binding and inhibition of function. Acyclovir 129-132 interferon gamma Homo sapiens 34-43 10800933-5 2000 The results demonstrate that KCI at 25-75 mM potently inhibits astrocyte nitrite production stimulated by interleukin-1 (IL-1)/interferon-gamma (IFNgamma). kci 29-32 interferon gamma Homo sapiens 127-143 10800933-5 2000 The results demonstrate that KCI at 25-75 mM potently inhibits astrocyte nitrite production stimulated by interleukin-1 (IL-1)/interferon-gamma (IFNgamma). kci 29-32 interferon gamma Homo sapiens 145-153 10800933-5 2000 The results demonstrate that KCI at 25-75 mM potently inhibits astrocyte nitrite production stimulated by interleukin-1 (IL-1)/interferon-gamma (IFNgamma). Nitrites 73-80 interferon gamma Homo sapiens 127-143 10800933-5 2000 The results demonstrate that KCI at 25-75 mM potently inhibits astrocyte nitrite production stimulated by interleukin-1 (IL-1)/interferon-gamma (IFNgamma). Nitrites 73-80 interferon gamma Homo sapiens 145-153 10857760-2 2000 Here, circular dichroism and fluorescence spectroscopic techniques are used to demonstrate that low molecular weight heparin and chondroitin sulfate cause significant changes in secondary and tertiary structure of IFN-gamma. Heparin 117-124 interferon gamma Homo sapiens 214-223 10857760-2 2000 Here, circular dichroism and fluorescence spectroscopic techniques are used to demonstrate that low molecular weight heparin and chondroitin sulfate cause significant changes in secondary and tertiary structure of IFN-gamma. Chondroitin Sulfates 129-148 interferon gamma Homo sapiens 214-223 10857760-3 2000 The results suggest that heparin and chondroitin sulfate modulate IFN-gamma activity by causing structural changes in the IFN-gamma dimer. Heparin 25-32 interferon gamma Homo sapiens 66-75 10857760-3 2000 The results suggest that heparin and chondroitin sulfate modulate IFN-gamma activity by causing structural changes in the IFN-gamma dimer. Heparin 25-32 interferon gamma Homo sapiens 122-131 10857760-3 2000 The results suggest that heparin and chondroitin sulfate modulate IFN-gamma activity by causing structural changes in the IFN-gamma dimer. Chondroitin Sulfates 37-56 interferon gamma Homo sapiens 66-75 10857760-3 2000 The results suggest that heparin and chondroitin sulfate modulate IFN-gamma activity by causing structural changes in the IFN-gamma dimer. Chondroitin Sulfates 37-56 interferon gamma Homo sapiens 122-131 10717345-3 2000 FPV gag/pol-IFNgamma vaccinations were safe and enhanced T cell proliferative responses to Gag antigens (but not control tetanus antigens). Glycosaminoglycans 91-94 interferon gamma Homo sapiens 12-20 10884608-2 2000 The cellular immune effector interferon gamma (IFN-gamma) inhibits chlamydial multiplication in human epithelial cells by induction of the tryptophan degrading enzyme indoleamine 2,3 dioxygenase. Tryptophan 139-149 interferon gamma Homo sapiens 29-56 10905622-4 2000 Our recent studies indicate the ability of cytokines, e.g., tumor necrosis factor-alpha (TNFalpha), interleukin-1beta (IL-1beta) and interferon-gamma (IFNgamma), to induce the inducible nitric oxide (iNOS) and secretory phospholipase A2 (sPLA2) genes in immortalized astrocytes (DITNC) (Li et al., J. Interferon and Cytokine Res. Nitric Oxide 186-198 interferon gamma Homo sapiens 133-149 10905622-4 2000 Our recent studies indicate the ability of cytokines, e.g., tumor necrosis factor-alpha (TNFalpha), interleukin-1beta (IL-1beta) and interferon-gamma (IFNgamma), to induce the inducible nitric oxide (iNOS) and secretory phospholipase A2 (sPLA2) genes in immortalized astrocytes (DITNC) (Li et al., J. Interferon and Cytokine Res. Nitric Oxide 186-198 interferon gamma Homo sapiens 151-159 10779805-5 2000 Whereas IFN-gamma pretreatment rendered SW480 cells sensitive to both Fas-dependent and -independent (perforin) pathways, SW620 cells displayed lytic susceptibility to Fas-independent mechanisms only. ammonium ferrous sulfate 70-73 interferon gamma Homo sapiens 8-17 10779805-8 2000 Overall, these data suggested that 1) IFN-gamma and 5-FU may enhance the lytic sensitivity of responsive colon carcinoma cells to immune effector mechanisms, including Fas-induced lysis; 2) the malignant phenotype may associate with resistance to Fas-mediated lysis in response to Ag-specific T cell attack; and 3) if Ag-specific CTL possess diverse lytic capabilities, this may overcome, to some extent, the potential "escape" of Fas-resistant carcinoma cells. ammonium ferrous sulfate 168-171 interferon gamma Homo sapiens 38-47 10779805-8 2000 Overall, these data suggested that 1) IFN-gamma and 5-FU may enhance the lytic sensitivity of responsive colon carcinoma cells to immune effector mechanisms, including Fas-induced lysis; 2) the malignant phenotype may associate with resistance to Fas-mediated lysis in response to Ag-specific T cell attack; and 3) if Ag-specific CTL possess diverse lytic capabilities, this may overcome, to some extent, the potential "escape" of Fas-resistant carcinoma cells. ammonium ferrous sulfate 247-250 interferon gamma Homo sapiens 38-47 10749688-10 2000 Rolipram dose-dependently inhibited the interferon-gamma (IFN-gamma)-stimulated phosphorylation of p38 mitogen-activated protein (MAP) kinase in a simple monotonic fashion with an IC(50) value of approx. Rolipram 0-8 interferon gamma Homo sapiens 58-67 10784002-5 2000 (2) To evaluate the effect of ursodeoxycholic acid and prednisone alone and in combination on serum levels of interferon-gamma and soluble inter-cellular adhesion molecule-1. Ursodeoxycholic Acid 30-50 interferon gamma Homo sapiens 110-173 10749688-10 2000 Rolipram dose-dependently inhibited the interferon-gamma (IFN-gamma)-stimulated phosphorylation of p38 mitogen-activated protein (MAP) kinase in a simple monotonic fashion with an IC(50) value of approx. Rolipram 0-8 interferon gamma Homo sapiens 40-56 10749688-13 2000 PDE4A4 was also selectively activated by challenge of U937 cells with either bacterial lipopolysaccharide (LPS) or IFN-gamma through a process which was attenuated by both wortmannin and rapamycin. Wortmannin 172-182 interferon gamma Homo sapiens 115-124 10749688-13 2000 PDE4A4 was also selectively activated by challenge of U937 cells with either bacterial lipopolysaccharide (LPS) or IFN-gamma through a process which was attenuated by both wortmannin and rapamycin. Sirolimus 187-196 interferon gamma Homo sapiens 115-124 10742653-6 2000 Clozapine 10(-6)M significantly increased the stimulated production of IFNgamma. Clozapine 0-9 interferon gamma Homo sapiens 71-79 10742653-7 2000 Clozapine 10(-4)M significantly suppressed the unstimulated production of IL-6 and IL-1RA and the stimulated production of IL-6, IL-10, IFNgamma and IL-1RA. Clozapine 0-9 interferon gamma Homo sapiens 136-144 10789681-2 2000 In contrast, the production of IFN-gamma was highly sensitive to FK506 (IC50 = 0.01 nM) and could be completely blocked by FK506. Tacrolimus 65-70 interferon gamma Homo sapiens 31-40 10789681-2 2000 In contrast, the production of IFN-gamma was highly sensitive to FK506 (IC50 = 0.01 nM) and could be completely blocked by FK506. Tacrolimus 123-128 interferon gamma Homo sapiens 31-40 10789681-4 2000 The combination of ionomycin and phorbol ester was able to mimic TCR stimulation to induce IFN-gamma production, although the same treatment triggered granule exocytosis inefficiently. Ionomycin 19-28 interferon gamma Homo sapiens 91-100 10789681-4 2000 The combination of ionomycin and phorbol ester was able to mimic TCR stimulation to induce IFN-gamma production, although the same treatment triggered granule exocytosis inefficiently. Phorbol Esters 33-46 interferon gamma Homo sapiens 91-100 10805218-7 2000 Treatment of the cells with 1 microM phorbol 12-myristate-13-acetate (PMA) stimulated IFN-gamma mRNA expression but had no effect on IFN-gamma protein production. Tetradecanoylphorbol Acetate 37-68 interferon gamma Homo sapiens 86-95 10805218-7 2000 Treatment of the cells with 1 microM phorbol 12-myristate-13-acetate (PMA) stimulated IFN-gamma mRNA expression but had no effect on IFN-gamma protein production. Tetradecanoylphorbol Acetate 70-73 interferon gamma Homo sapiens 86-95 10805225-0 2000 Interferon gamma inhibits proliferation and hyaluronic acid adhesion of human malignant glioma cells in vitro. Hyaluronic Acid 44-59 interferon gamma Homo sapiens 0-16 10754309-6 2000 The inhibition of CpG methylation in Jar cells by treatment with 5-aza-2"-deoxycytidine restores IFN-gamma inducibility to CIITA. Decitabine 65-87 interferon gamma Homo sapiens 97-106 10767420-0 2000 Induction of superoxide in glioma cell line U87 stimulated with lipopolysaccharide and interferon-gamma: ESR using a new flow-type quartz cell. Superoxides 13-23 interferon gamma Homo sapiens 87-103 10767420-1 2000 The production of superoxide and nitric oxide induced in U87 glioma treated with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) was examined by electron spin resonance (ESR) spectroscopy using a newly designed flow-type quartz cuvette without detaching cells from the culture plate. Superoxides 18-28 interferon gamma Homo sapiens 110-126 10767420-1 2000 The production of superoxide and nitric oxide induced in U87 glioma treated with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) was examined by electron spin resonance (ESR) spectroscopy using a newly designed flow-type quartz cuvette without detaching cells from the culture plate. Superoxides 18-28 interferon gamma Homo sapiens 128-137 10767420-1 2000 The production of superoxide and nitric oxide induced in U87 glioma treated with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) was examined by electron spin resonance (ESR) spectroscopy using a newly designed flow-type quartz cuvette without detaching cells from the culture plate. Nitric Oxide 33-45 interferon gamma Homo sapiens 128-137 10767420-5 2000 By the spin-trapping method, nitric oxide from U87 cells pretreated with LPS/IFN-gamma for 24 h was measured by the ESR, but only a weak signal of nitric oxide adducts was detected. Nitric Oxide 29-41 interferon gamma Homo sapiens 77-86 10767420-6 2000 Further, the nitrite and nitrate levels in the medium did not increase for 24 h. By the ESR measurement of cells on culture plates without detachment stress, it was found that the production of superoxide was induced by LPS/IFN-gamma, but that of nitric oxide was not, in U87 glioma cells. Superoxides 194-204 interferon gamma Homo sapiens 224-233 18034532-5 2000 Thalidomide produces partial inhibition of tumour necrosis factor-alpha production in vivo but recent data reveals that it can also act as a co-stimulatory molecule for T cell activation in vitro, resulting in increased production of interleukin-2 and interferon-gamma. Thalidomide 0-11 interferon gamma Homo sapiens 252-268 10722595-4 2000 Both the fever and the increased levels of IL-1, TNF, IFN-gamma, IL-2, and IL-6 in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with anisomycin (a protein synthesis inhibitor), aminoguanidine (an inhibitor of inducible nitric oxide synthase [NOS]), or dexamethasone (an inhibitor of NOS). Anisomycin 183-193 interferon gamma Homo sapiens 54-63 10784002-5 2000 (2) To evaluate the effect of ursodeoxycholic acid and prednisone alone and in combination on serum levels of interferon-gamma and soluble inter-cellular adhesion molecule-1. Prednisone 55-65 interferon gamma Homo sapiens 110-173 10792507-10 2000 The effect of IFN-gamma on RANTES mRNA was reversed by cycloheximide, suggesting that IFN-gamma may act by increasing the rate of translation of RANTES mRNA. Cycloheximide 55-68 interferon gamma Homo sapiens 14-23 10792507-10 2000 The effect of IFN-gamma on RANTES mRNA was reversed by cycloheximide, suggesting that IFN-gamma may act by increasing the rate of translation of RANTES mRNA. Cycloheximide 55-68 interferon gamma Homo sapiens 86-95 10864407-0 2000 Reciprocal inhibitory interactions between interferon gamma and histamine in melanoma. Histamine 64-73 interferon gamma Homo sapiens 43-59 10834318-3 2000 IFN-gamma stimulates the enzyme indoleamine (2,3)-dioxygenase (IDO) converting tryptophan to the metabolite kynurenine which in macrophages is subsequently degraded to other, partly neurotoxic compounds like quinolinic acid, and finally to nicrotinamides. indolamine 32-43 interferon gamma Homo sapiens 0-9 10834318-3 2000 IFN-gamma stimulates the enzyme indoleamine (2,3)-dioxygenase (IDO) converting tryptophan to the metabolite kynurenine which in macrophages is subsequently degraded to other, partly neurotoxic compounds like quinolinic acid, and finally to nicrotinamides. Tryptophan 79-89 interferon gamma Homo sapiens 0-9 10834318-3 2000 IFN-gamma stimulates the enzyme indoleamine (2,3)-dioxygenase (IDO) converting tryptophan to the metabolite kynurenine which in macrophages is subsequently degraded to other, partly neurotoxic compounds like quinolinic acid, and finally to nicrotinamides. Kynurenine 108-118 interferon gamma Homo sapiens 0-9 10834318-3 2000 IFN-gamma stimulates the enzyme indoleamine (2,3)-dioxygenase (IDO) converting tryptophan to the metabolite kynurenine which in macrophages is subsequently degraded to other, partly neurotoxic compounds like quinolinic acid, and finally to nicrotinamides. Quinolinic Acid 208-223 interferon gamma Homo sapiens 0-9 10759183-0 2000 Interferon-gamma modulates human oligodendrocyte susceptibility to Fas-mediated apoptosis. ammonium ferrous sulfate 67-70 interferon gamma Homo sapiens 0-16 10834318-3 2000 IFN-gamma stimulates the enzyme indoleamine (2,3)-dioxygenase (IDO) converting tryptophan to the metabolite kynurenine which in macrophages is subsequently degraded to other, partly neurotoxic compounds like quinolinic acid, and finally to nicrotinamides. nicrotinamides 240-254 interferon gamma Homo sapiens 0-9 10779013-3 2000 The NOS-2 activity, assessed by nitrite accumulation, was absent from untreated cultures but was induced by interleukin-1beta and interferon-gamma acting synergistically. Nitrites 32-39 interferon gamma Homo sapiens 130-146 10764830-0 2000 Remodeling of sugar chain structures of human interferon-gamma. Sugars 14-19 interferon gamma Homo sapiens 46-62 10764830-1 2000 Natural human interferon (IFN)-gamma has mainly biantennary complex-type sugar chains and scarcely has multiantennary structures. Sugars 73-78 interferon gamma Homo sapiens 14-36 10764830-2 2000 We attempted to remodel the sugar chain structures using IFN-gamma as a model glycoprotein. Sugars 28-33 interferon gamma Homo sapiens 57-66 10759183-6 2000 Furthermore, IFN-gamma-treated OLs became susceptible to Fas-mediated apoptosis when compared with untreated cells, and were protected by pretreatment with the caspase inhibitor ZVAD. N-biotin-C-Co4(mu3-O)4(Py)4(H2O)4-beta-alanine 31-34 interferon gamma Homo sapiens 13-22 10764830-4 2000 The parental CHO cells produced IFN-gamma with biantennary sugar chains mainly. cho 13-16 interferon gamma Homo sapiens 32-41 10764830-9 2000 What is more, lectin blot and flow cytometric analysis indicated that the multi-branch structure of the sugar chains was increased not only on IFN-gamma, one of the secretory glycoproteins, but also on almost CHO cellular proteins by introducing either or both of the GnT genes. Sugars 104-109 interferon gamma Homo sapiens 143-152 10759183-6 2000 Furthermore, IFN-gamma-treated OLs became susceptible to Fas-mediated apoptosis when compared with untreated cells, and were protected by pretreatment with the caspase inhibitor ZVAD. ammonium ferrous sulfate 57-60 interferon gamma Homo sapiens 13-22 10759183-6 2000 Furthermore, IFN-gamma-treated OLs became susceptible to Fas-mediated apoptosis when compared with untreated cells, and were protected by pretreatment with the caspase inhibitor ZVAD. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 178-182 interferon gamma Homo sapiens 13-22 10759183-8 2000 Our results thus indicate that IFN-gamma is not directly cytotoxic for human OLs in culture, but could indirectly modulate functional injury-related responses by upregulating Fas on the cell surface. ammonium ferrous sulfate 175-178 interferon gamma Homo sapiens 31-40 10810019-1 2000 OBJECTIVE: To investigate if severe malarial anaemia is associated with a specific immune response pattern, we determined serum levels of neopterin (a marker of activation of macrophages by interferon-gamma) and of the anti-inflammatory cytokines, interleukins 4 and 10. Neopterin 138-147 interferon gamma Homo sapiens 190-206 10782806-5 2000 RESULTS: Bucillamine decreased the frequency of interferon-gamma (IFN-gamma) producing CD4+ T cells among generated CD4+ T cells after the priming culture of PBMC, although D-penicillamine did not. bucillamine 9-20 interferon gamma Homo sapiens 48-64 10782806-5 2000 RESULTS: Bucillamine decreased the frequency of interferon-gamma (IFN-gamma) producing CD4+ T cells among generated CD4+ T cells after the priming culture of PBMC, although D-penicillamine did not. bucillamine 9-20 interferon gamma Homo sapiens 66-75 10782806-7 2000 One of the bucillamine metabolites, SA981, which exerts its effects by a hydrogen peroxide-independent mechanism, decreased the frequency of IFN-gamma producing CD4+ T cells more potently than bucillamine. bucillamine 11-22 interferon gamma Homo sapiens 141-150 10782806-7 2000 One of the bucillamine metabolites, SA981, which exerts its effects by a hydrogen peroxide-independent mechanism, decreased the frequency of IFN-gamma producing CD4+ T cells more potently than bucillamine. bucillamine disulfide 36-41 interferon gamma Homo sapiens 141-150 10729320-1 2000 The effect of interferon-gamma on indoleamine 2,3-dioxygenase, a tryptophan catabolizing enzyme, was studied in cultured human placental chorionic villi. Tryptophan 65-75 interferon gamma Homo sapiens 14-30 10810020-0 2000 Markers of inflammation in children with severe malarial anaemia objective To investigate if severe malarial anaemia is associated with a specific immune response pattern, we determined serum levels of neopterin (a marker of activation of macrophages by interferon-gamma) and of the anti-inflammatory cytokines, interleukins 4 and 10. methods Zambian children < 6 years of age presenting to a rural hospital with cerebral malaria were studied. Neopterin 202-211 interferon gamma Homo sapiens 254-270 10712667-11 2000 The production of cytokines which are involved in the regulation of the cytotoxic process (tumour necrosis factor-alpha, interferon-gamma, IL-10, IL-12 and transforming growth factor-beta1) was also affected by pHe, as their release was strongly inhibited at pHe 7.0. Phenylalanine 211-214 interferon gamma Homo sapiens 121-137 10891397-2 2000 In the current study we investigated the regulatory capacity of reactive oxygen intermediates (ROIs) in ICAM-1 activation by stimulating endothelial cells with the pro-inflammatory cytokines IL-1 beta, TNF alpha, IFN gamma, IL-2, and IL-4 prior to antioxidant treatment. reactive oxygen intermediates 64-93 interferon gamma Homo sapiens 213-222 10717289-19 2000 We speculate that T cell cytokines such as interferon (IFN)-gamma may stimulate macrophages to produce nitric oxide (NO) and other cytokines with anti-proliferative activity. Nitric Oxide 103-115 interferon gamma Homo sapiens 43-65 10780664-8 2000 In contrast, a clear induction of Fas-mediated apoptosis by anti-Fas IgM was determined in interferon-gamma (IFN-gamma)-stimulated thyrocytes. ammonium ferrous sulfate 34-37 interferon gamma Homo sapiens 91-107 10780664-8 2000 In contrast, a clear induction of Fas-mediated apoptosis by anti-Fas IgM was determined in interferon-gamma (IFN-gamma)-stimulated thyrocytes. ammonium ferrous sulfate 34-37 interferon gamma Homo sapiens 109-118 10732894-4 2000 Increased serum concentration of neopterin, a pterydine derivative secreted by macrophages after stimulation by interferon-gamma, has been observed in patients with acute coronary syndromes as compared with control subjects and patients with stable angina pectoris. Neopterin 33-42 interferon gamma Homo sapiens 112-128 10732894-4 2000 Increased serum concentration of neopterin, a pterydine derivative secreted by macrophages after stimulation by interferon-gamma, has been observed in patients with acute coronary syndromes as compared with control subjects and patients with stable angina pectoris. pterydine 46-55 interferon gamma Homo sapiens 112-128 10753012-3 2000 Nevertheless, the IFN-gamma-mediated upregulation of ICAM-1/CD54 was inhibited by treatment with CTZ, demonstrating a direct effect on both cell types. Cetirizine 97-100 interferon gamma Homo sapiens 18-27 10660117-3 2000 Treatment of P ll cells with interferon-gamma and lipopolysaccharide resulted in a 23-fold increase in nitrite production and induced expression of iNOS protein. Nitrites 103-110 interferon gamma Homo sapiens 29-45 10702485-2 2000 We have used a modified version of the ELISPOT assay to monitor changes in the frequency of gamma interferon (IFN-gamma)-producing T cells in a population of lymphocytes responding to a relevant peptide or a nonspecific stimulator, such as phorbol myristate acetate-ionomycin. Tetradecanoylphorbol Acetate 240-265 interferon gamma Homo sapiens 92-119 10702485-2 2000 We have used a modified version of the ELISPOT assay to monitor changes in the frequency of gamma interferon (IFN-gamma)-producing T cells in a population of lymphocytes responding to a relevant peptide or a nonspecific stimulator, such as phorbol myristate acetate-ionomycin. Ionomycin 266-275 interferon gamma Homo sapiens 92-119 10818267-7 2000 The sensitivity to sulfated polysaccharides indicated an involvement of oligobasic epitopes of hIFN-gamma in the binding. Polysaccharides 28-43 interferon gamma Homo sapiens 95-105 10818267-11 2000 Also, acidic polysaccharides such as heparin were much more efficacious in the inhibition of hIFN-gamma binding to hemolymph relative to protocerebral particulates. Polysaccharides 13-28 interferon gamma Homo sapiens 93-103 10818267-11 2000 Also, acidic polysaccharides such as heparin were much more efficacious in the inhibition of hIFN-gamma binding to hemolymph relative to protocerebral particulates. Heparin 37-44 interferon gamma Homo sapiens 93-103 10818267-13 2000 The selectivity observed with M. sexta particulates indicates a preferential involvement of oligobasic lysine-rich C-terminal sequences of IFN-gamma, while large insect tissue-related affinity differences point to involvement of diverse oligoacidic sequences in binding to protocerebrum and hemolymph sites. Lysine 103-109 interferon gamma Homo sapiens 139-148 10821462-0 2000 Il-4 and IFN-gamma mRNA induction in human peripheral lymphocytes specific for beta-lactam antibiotics in immediate or delayed hypersensitivity reactions. beta-Lactams 79-90 interferon gamma Homo sapiens 9-18 10821462-8 2000 IL-4 mRNA expression was only induced following activation with free drugs, while IFN-gamma mRNA expression was predominantly induced in CD4+ T cells following stimulation with HSA-conjugated drugs. Altretamine 177-180 interferon gamma Homo sapiens 82-91 10706588-6 2000 Assay of [(3)H]cholesterol linoleate-labeled lipoproteins indicated that total uptake and hydrolysis of [(3)H]cholesterol linoleate was similar for each class of receptor, and inhibited by IFN-gamma. [(3)h]cholesterol linoleate 9-36 interferon gamma Homo sapiens 189-198 10700460-9 2000 Blocking the p38 MAPK pathway by SB203580 completely inhibited IFN-gamma production from A6H co-stimulated T cells and radically reduced IFN-gamma production from T cells co-stimulated with anti-CD28. SB 203580 33-41 interferon gamma Homo sapiens 63-72 10700460-9 2000 Blocking the p38 MAPK pathway by SB203580 completely inhibited IFN-gamma production from A6H co-stimulated T cells and radically reduced IFN-gamma production from T cells co-stimulated with anti-CD28. 6-(2,6-dichlorophenoxy)pyridin-3-amine 89-92 interferon gamma Homo sapiens 63-72 10762082-3 2000 Four (2-C-4, 9-H-6, 11-H-5, and 12-C-12) of 10 neutralized the biologic activity of PoIL-18 to induce interferon-y (IFN-gamma) from porcine peripheral blood mononuclear cells (PBMC). 2-c 6-9 interferon gamma Homo sapiens 116-125 10762082-3 2000 Four (2-C-4, 9-H-6, 11-H-5, and 12-C-12) of 10 neutralized the biologic activity of PoIL-18 to induce interferon-y (IFN-gamma) from porcine peripheral blood mononuclear cells (PBMC). 9-h 13-16 interferon gamma Homo sapiens 116-125 10762082-3 2000 Four (2-C-4, 9-H-6, 11-H-5, and 12-C-12) of 10 neutralized the biologic activity of PoIL-18 to induce interferon-y (IFN-gamma) from porcine peripheral blood mononuclear cells (PBMC). 11-h 20-24 interferon gamma Homo sapiens 116-125 10762082-3 2000 Four (2-C-4, 9-H-6, 11-H-5, and 12-C-12) of 10 neutralized the biologic activity of PoIL-18 to induce interferon-y (IFN-gamma) from porcine peripheral blood mononuclear cells (PBMC). 5-(2-formyl-3-hydroxyphenoxy)pentanoic acid 32-36 interferon gamma Homo sapiens 116-125 10762082-3 2000 Four (2-C-4, 9-H-6, 11-H-5, and 12-C-12) of 10 neutralized the biologic activity of PoIL-18 to induce interferon-y (IFN-gamma) from porcine peripheral blood mononuclear cells (PBMC). poil-18 84-91 interferon gamma Homo sapiens 116-125 10679076-8 2000 The modulation of phenotype and function of DCs matured in the presence of 1,25(OH)2D3 induces cocultured alloreactive CD4+ cells to secrete less IFN-gamma upon restimulation, up-regulate CD152, and down-regulate CD154 molecules. Calcitriol 75-86 interferon gamma Homo sapiens 146-155 10692108-6 2000 Interferon-gamma and the phorbolester 12-O-tetradecanoyl phorbol 13-acetate, two well-known inducers of keratinocyte differentiation, both inhibited vitamin D receptor expression but only interferon-gamma induced retinoid X receptor alpha. Tetradecanoylphorbol Acetate 38-75 interferon gamma Homo sapiens 188-204 10692108-7 2000 The decreased vitamin D receptor expression was accompanied by reduced vitamin D responsiveness (as assessed by 24-hydroxylase mRNA induction) in postconfluent, high calcium, and 12-O-tetradecanoyl phorbol 13-acetate treated keratinocytes but not with interferon-gamma treatment. Vitamin D 14-23 interferon gamma Homo sapiens 252-268 10720518-2 2000 Thalidomide therapy resulted in increased levels of plasma interleukin (IL)-2 receptor, soluble CD8, interferon-gamma, and IL-12, indicating immune stimulation. Thalidomide 0-11 interferon gamma Homo sapiens 101-117 10706588-6 2000 Assay of [(3)H]cholesterol linoleate-labeled lipoproteins indicated that total uptake and hydrolysis of [(3)H]cholesterol linoleate was similar for each class of receptor, and inhibited by IFN-gamma. [(3)h]cholesterol linoleate 104-131 interferon gamma Homo sapiens 189-198 10706588-7 2000 For FcgammaRI versus FcgammaRIIA, in the presence or absence of IFN-gamma, the [(3)H]cholesterol derived from FcgammaRIIA-mediated uptake was preferentially targeted for re-esterification to [(3)H]cholesterol oleate, in comparison to that resulting from hydrolysis of [(3)H]cholesterol linoleate incorporated by selective uptake. [(3)h]cholesterol 79-96 interferon gamma Homo sapiens 64-73 10706588-8 2000 For SRA, the formation of [(3)H]cholesterol oleate, which was substantial in control cells, was significantly inhibited in the presence of IFN-gamma. [(3)h]cholesterol oleate 26-50 interferon gamma Homo sapiens 139-148 12579726-1 2000 OBJECTIVE: To observe the effects of immunosuppressants triptolide (TL) and cyclosporine A (CSA) on HLA antigens expression induced by interferon-gamma(INF-gamma) in vitro. triptolide 56-66 interferon gamma Homo sapiens 135-161 10681439-0 2000 IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma. Prostaglandins 61-74 interferon gamma Homo sapiens 104-113 10681439-6 2000 The suppressive effect of IL-18 on PGE(2) production was mediated by interferon (IFN)-gamma because anti-human IFN-gamma-antibody prevented IL-18-induced reduction in PGE(2). Prostaglandins E 35-38 interferon gamma Homo sapiens 69-91 10681439-6 2000 The suppressive effect of IL-18 on PGE(2) production was mediated by interferon (IFN)-gamma because anti-human IFN-gamma-antibody prevented IL-18-induced reduction in PGE(2). Prostaglandins E 35-38 interferon gamma Homo sapiens 111-120 10681439-6 2000 The suppressive effect of IL-18 on PGE(2) production was mediated by interferon (IFN)-gamma because anti-human IFN-gamma-antibody prevented IL-18-induced reduction in PGE(2). Prostaglandins E 167-170 interferon gamma Homo sapiens 69-91 10681439-6 2000 The suppressive effect of IL-18 on PGE(2) production was mediated by interferon (IFN)-gamma because anti-human IFN-gamma-antibody prevented IL-18-induced reduction in PGE(2). Prostaglandins E 167-170 interferon gamma Homo sapiens 111-120 10681439-7 2000 Consistent with these observations, IL-12, a known inducer of IFN-gamma, augmented IL-1beta-induced IFN-gamma but suppressed IL-1beta-induced PGE(2) by 75%. Prostaglandins E 142-145 interferon gamma Homo sapiens 62-71 12579726-0 2000 The effects of triptolide on HLA antigens expression of corneal epithelial cells induced by interferon-gamma in vitro. triptolide 15-25 interferon gamma Homo sapiens 92-108 12579726-1 2000 OBJECTIVE: To observe the effects of immunosuppressants triptolide (TL) and cyclosporine A (CSA) on HLA antigens expression induced by interferon-gamma(INF-gamma) in vitro. triptolide 68-70 interferon gamma Homo sapiens 135-161 12579726-1 2000 OBJECTIVE: To observe the effects of immunosuppressants triptolide (TL) and cyclosporine A (CSA) on HLA antigens expression induced by interferon-gamma(INF-gamma) in vitro. Cyclosporine 76-90 interferon gamma Homo sapiens 135-161 12579728-7 2000 The inhibition rate of IFN-gamma in two experiments was smaller than MMC and 5-Fu (P < 0.05). Mitomycin 69-72 interferon gamma Homo sapiens 23-32 12579728-7 2000 The inhibition rate of IFN-gamma in two experiments was smaller than MMC and 5-Fu (P < 0.05). Fluorouracil 77-81 interferon gamma Homo sapiens 23-32 10657627-1 2000 IFN-gamma transduces signals by activating the IFN-gamma receptor-associated Jak-1 and Jak-2 kinases and by inducing tyrosine phosphorylation and activation of the Stat-1 transcriptional activator. Tyrosine 117-125 interferon gamma Homo sapiens 0-9 10675752-3 2000 Adsorption of CFF onto polystyrene microspheres, that were approximately the size of the M. tuberculosis (bead-adsorbed antigens, BAA) significantly enhanced IFN-gamma production compared to soluble antigens (SA) in PPD skin test positive individuals in an antigen-specific manner. Polystyrenes 23-34 interferon gamma Homo sapiens 158-167 10657627-3 2000 During treatment of NB-4 human cells with IFN-gamma, c-cbl protooncogene product is rapidly phosphorylated on tyrosine and provides a docking site for the src homology 2 domain of CrkL, which also undergoes IFN-gamma-dependent tyrosine phosphorylation. Tyrosine 110-118 interferon gamma Homo sapiens 42-51 10657627-3 2000 During treatment of NB-4 human cells with IFN-gamma, c-cbl protooncogene product is rapidly phosphorylated on tyrosine and provides a docking site for the src homology 2 domain of CrkL, which also undergoes IFN-gamma-dependent tyrosine phosphorylation. Tyrosine 227-235 interferon gamma Homo sapiens 42-51 10735602-7 2000 However, by in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, peripheral CD4 cells demonstrated a significant decrease of IFN-gamma-producing T helper 1 (Th1) cells and an increase of IL-4-producing T helper 2 (Th2) cells after immunotherapy. Tetradecanoylphorbol Acetate 37-68 interferon gamma Homo sapiens 150-159 10690516-2 2000 Interleukin (IL)-1 alpha, IL-6, and IL-12 induction by ONO-4007 activates cytotoxic natural killer cells to up-regulate IFN-gamma and nitric oxide synthase activity. ONO 4007 55-63 interferon gamma Homo sapiens 120-129 10669765-7 2000 The frequency distribution of IL-4 and interferon-gamma (IFN-gamma) CBMC responses to allergens in the general population approximates to a log-normal distribution, which will permit the application of linear regression techniques in the identification of in utero factors which influence Th bias. cbmc 68-72 interferon gamma Homo sapiens 39-55 10669765-7 2000 The frequency distribution of IL-4 and interferon-gamma (IFN-gamma) CBMC responses to allergens in the general population approximates to a log-normal distribution, which will permit the application of linear regression techniques in the identification of in utero factors which influence Th bias. cbmc 68-72 interferon gamma Homo sapiens 57-66 10685665-10 2000 Gangliosides isolated from tumor supernatants blocked the production of IL-2 and IFN-gamma in response to ionomycin plus phorbol myristate acetate stimulation. Gangliosides 0-12 interferon gamma Homo sapiens 81-90 10685665-10 2000 Gangliosides isolated from tumor supernatants blocked the production of IL-2 and IFN-gamma in response to ionomycin plus phorbol myristate acetate stimulation. Ionomycin 106-115 interferon gamma Homo sapiens 81-90 10685665-10 2000 Gangliosides isolated from tumor supernatants blocked the production of IL-2 and IFN-gamma in response to ionomycin plus phorbol myristate acetate stimulation. Tetradecanoylphorbol Acetate 121-146 interferon gamma Homo sapiens 81-90 10761626-11 2000 IFN-gamma only reacts at high concentrations of cadmium. Cadmium 48-55 interferon gamma Homo sapiens 0-9 10685001-7 2000 In the presence of L-NAME, PMA (1 nM) stimulation significantly increased superoxide anion generation following 3 h treatments with IL-3, TNF-alpha or IFN-gamma. NG-Nitroarginine Methyl Ester 19-25 interferon gamma Homo sapiens 151-160 10685001-7 2000 In the presence of L-NAME, PMA (1 nM) stimulation significantly increased superoxide anion generation following 3 h treatments with IL-3, TNF-alpha or IFN-gamma. Tetradecanoylphorbol Acetate 27-30 interferon gamma Homo sapiens 151-160 10685001-7 2000 In the presence of L-NAME, PMA (1 nM) stimulation significantly increased superoxide anion generation following 3 h treatments with IL-3, TNF-alpha or IFN-gamma. Superoxides 74-90 interferon gamma Homo sapiens 151-160 10685001-8 2000 Eighteen hour cytokine treatments with GM-CSF, IL-8, RANTES, IFN-gamma or TNF-alpha primed the cells for enhanced reactive oxygen species following exposure to an EOS stimulant. Reactive Oxygen Species 114-137 interferon gamma Homo sapiens 61-70 10735602-7 2000 However, by in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, peripheral CD4 cells demonstrated a significant decrease of IFN-gamma-producing T helper 1 (Th1) cells and an increase of IL-4-producing T helper 2 (Th2) cells after immunotherapy. Tetradecanoylphorbol Acetate 70-73 interferon gamma Homo sapiens 150-159 10735602-7 2000 However, by in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, peripheral CD4 cells demonstrated a significant decrease of IFN-gamma-producing T helper 1 (Th1) cells and an increase of IL-4-producing T helper 2 (Th2) cells after immunotherapy. Ionomycin 79-88 interferon gamma Homo sapiens 150-159 10640755-7 2000 Transfection of a -2.7-kb IFN-gamma promoter-reporter construct into PBL and LP mononuclear cells (LPMC) revealed significant promoter activity after CD2 activation, with additional transactivation after CD2/CD28 costimulation in PBL, but not in LPMC. lpmc 99-103 interferon gamma Homo sapiens 26-35 10669857-8 2000 The addition of rIL-12 (10 ng/mL) to DC-T cell cocultures resulted in the induction of IFN-gamma secretion by Der p 1-specific CD4(+) T cells from atopic patients, whereas their production of IL-5 was not inhibited. ril-12 16-22 interferon gamma Homo sapiens 87-96 10651989-3 2000 Here, we examined the properties of a subset of nickel-specific CD4+ T cells displaying the cytokine profile (IL-10 , IL-5 , IFN-gamma+/-, IL-4+/-) of T regulatory cells 1 (Tr1) and with the potential to down-modulate immune responses to nickel. Nickel 48-54 interferon gamma Homo sapiens 125-134 10714548-1 2000 IFN-gamma treatment of the human carcinoma cell line ME180 causes cell death due to induction of indoleamine 2,3-dioxygenase (IDO) and resulting starvation for tryptophan. Tryptophan 160-170 interferon gamma Homo sapiens 0-9 10714554-4 2000 The aim of this study was to investigate the frequency of a CA dinucleotide repeat polymorphism in the interferon-gamma (IFN-gamma) gene (IFNG) and a C(-590)T polymorphism of the interleukin-4 (IL-4) gene in 236 Caucasoid patients with type 1 diabetes. ca dinucleotide 60-75 interferon gamma Homo sapiens 103-119 10714554-4 2000 The aim of this study was to investigate the frequency of a CA dinucleotide repeat polymorphism in the interferon-gamma (IFN-gamma) gene (IFNG) and a C(-590)T polymorphism of the interleukin-4 (IL-4) gene in 236 Caucasoid patients with type 1 diabetes. ca dinucleotide 60-75 interferon gamma Homo sapiens 138-142 10627535-2 2000 In this study, we investigated why mouse macrophages expressing human CD46 restricted MV replication and produced higher levels of nitric oxide (NO) in response to MV and gamma interferon (IFN-gamma). Nitric Oxide 131-143 interferon gamma Homo sapiens 189-198 10652024-14 2000 We found that IL-15 is produced by HPMCs, and IFN-gamma up-regulated its mRNA levels and protein secretion in a dose-dependent manner. hpmcs 35-40 interferon gamma Homo sapiens 46-55 10872507-0 2000 Modulation of human interferon-gamma biosynthesis by antisense oligodeoxynucleotides. Oligodeoxyribonucleotides 63-84 interferon gamma Homo sapiens 20-36 10692033-0 2000 CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-gamma production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type I and interleukin-12. CPG-oligonucleotide 0-25 interferon gamma Homo sapiens 60-76 10640755-13 2000 This report provides evidence that activation of LPMC results in transactivation of multiple promoter elements regulating IFN-gamma expression distinct from those in PBL. lpmc 49-53 interferon gamma Homo sapiens 122-131 10645003-6 2000 IFN-gamma also rapidly and transiently activates extracellular signal-regulated kinase 1,2 (ERK1,2) and blocking ERK1,2 pathway (Raf/MEK1,2/ERK1,2) by specific MEK1,2 inhibitor PD98059 partially (by 50%) prevents Ser-727 phosphorylation of STAT1 and suppression of MMP-13 expression by IFN-gamma. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 177-184 interferon gamma Homo sapiens 0-9 10648857-3 2000 Here, we have optimized a previously established test based on assessing the formation of neopterin or nitrite in interferon-gamma-treated human (THP-1) or murine (J774A.1, RAW264.7) monocytoid cell lines, respectively, in response to bacterial pyrogens. Nitrites 103-110 interferon gamma Homo sapiens 114-130 10721852-0 2000 Interferon-gamma production in the peripheral lymphocytes of a patient with carbamazepine hypersensitivity syndrome. Carbamazepine 76-89 interferon gamma Homo sapiens 0-16 10849740-3 2000 Here, we describe for the first time the quantitative changes of mRNA expression of IFN-gamma, IL-2, IL-12 and DP IV after inhibition of DP IV. dp 137-139 interferon gamma Homo sapiens 84-93 10849742-4 2000 The DP IV inhibitors Lys[Z(NO2)]-thiazolidide and Lys[Z(NO2)]-pyrrolidide suppress in a dose-dependent manner DNA synthesis and IFN-gamma, IL-4, and TNF-alpha production of the antigen-stimulated TCC. lysyl-(Z(nitro))thiazolidide 21-45 interferon gamma Homo sapiens 128-137 10849742-4 2000 The DP IV inhibitors Lys[Z(NO2)]-thiazolidide and Lys[Z(NO2)]-pyrrolidide suppress in a dose-dependent manner DNA synthesis and IFN-gamma, IL-4, and TNF-alpha production of the antigen-stimulated TCC. lysyl-(Z(nitro))pyrrolidide 50-73 interferon gamma Homo sapiens 128-137 11154044-4 2000 The inhibitory mechanisms may involve the blocking of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production, since VC-ME suppressed IL-2 and IFN-gamma production of HMNC in a dose-dependent manner. vc-me 126-131 interferon gamma Homo sapiens 79-95 11154044-4 2000 The inhibitory mechanisms may involve the blocking of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production, since VC-ME suppressed IL-2 and IFN-gamma production of HMNC in a dose-dependent manner. vc-me 126-131 interferon gamma Homo sapiens 97-106 11154044-4 2000 The inhibitory mechanisms may involve the blocking of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production, since VC-ME suppressed IL-2 and IFN-gamma production of HMNC in a dose-dependent manner. vc-me 126-131 interferon gamma Homo sapiens 152-161 10644863-9 2000 A significant number of IFN-gamma- and IL-2-expressing T lymphocytes were only detected after 18 hours of PMA/ionomycin stimulation. Tetradecanoylphorbol Acetate 106-109 interferon gamma Homo sapiens 24-33 10644863-9 2000 A significant number of IFN-gamma- and IL-2-expressing T lymphocytes were only detected after 18 hours of PMA/ionomycin stimulation. Ionomycin 110-119 interferon gamma Homo sapiens 24-33 10645005-4 2000 Immunoblot analyses revealed that unstimulated B-CLL cells expressed detectable levels of serine/tyrosine-phosphorylated Stat1alpha, and RA and IFN-gamma treatment led to increased levels of tyrosine phosphorylation of Stat1alpha and its nuclear accumulation. Tyrosine 191-199 interferon gamma Homo sapiens 144-153 10648857-3 2000 Here, we have optimized a previously established test based on assessing the formation of neopterin or nitrite in interferon-gamma-treated human (THP-1) or murine (J774A.1, RAW264.7) monocytoid cell lines, respectively, in response to bacterial pyrogens. Neopterin 90-99 interferon gamma Homo sapiens 114-130 10645003-6 2000 IFN-gamma also rapidly and transiently activates extracellular signal-regulated kinase 1,2 (ERK1,2) and blocking ERK1,2 pathway (Raf/MEK1,2/ERK1,2) by specific MEK1,2 inhibitor PD98059 partially (by 50%) prevents Ser-727 phosphorylation of STAT1 and suppression of MMP-13 expression by IFN-gamma. Serine 213-216 interferon gamma Homo sapiens 0-9 10874472-1 2000 The branched chain amino acid-preferring (BrAAP) activity of multicatalytic proteinase complex isolated from human umbilical vein endothelial cells and treated with interferon-gamma was increased more than 2-fold, which was associated with a marked increase in LMP7 expression and decreased peptidylglutamyl peptide-hydrolyzing activity. Amino Acids, Branched-Chain 4-29 interferon gamma Homo sapiens 165-181 11059563-0 2000 Production of tumor necrosis factor-alpha and interferon-gamma from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylan from rice bran, and its synergy with interleukin-2 in vitro. arabinoxylan 124-136 interferon gamma Homo sapiens 46-62 11059641-5 2000 IFN-gamma also stimulates the production of neopterin, a low-mass compound, in human monocytes/macrophages. Neopterin 44-53 interferon gamma Homo sapiens 0-9 11059641-7 2000 Since IFN-gamma also stimulates the release of reactive oxygen species (ROS) from immunocompetents cells, the amount of neopterin produced also serves as an indirect estimate of oxidative stress. Reactive Oxygen Species 47-70 interferon gamma Homo sapiens 6-15 11059641-7 2000 Since IFN-gamma also stimulates the release of reactive oxygen species (ROS) from immunocompetents cells, the amount of neopterin produced also serves as an indirect estimate of oxidative stress. Reactive Oxygen Species 72-75 interferon gamma Homo sapiens 6-15 11059641-8 2000 In parallel, IFN-gamma activates the degradation of tryptophan, which appears to limit the growth of intracellular pathogens and the proliferation of cells, including T lymphocytes. Tryptophan 52-62 interferon gamma Homo sapiens 13-22 11059646-0 2000 Effect of recombinant IFN-gamma on igE-dependent leukotriene generation by peripheral blood leukocytes in patients with pollinosis and asthma. Leukotrienes 49-60 interferon gamma Homo sapiens 22-31 11059646-3 2000 The aim of the study was to evaluate the influence of IFN-gamma on leukotriene (LT) release in vitro, from human leukocytes of atopic patients with pollinosis and asthma. Leukotrienes 67-78 interferon gamma Homo sapiens 54-63 10684990-6 2000 Imipenem decreased the release of IL4 and Interferon-gamma by T-cell clones stimulated with anti-CD3 and PHA in the presence of native (nonirradiated) AML blasts. Imipenem 0-8 interferon gamma Homo sapiens 42-58 10607486-7 2000 IFN-gamma secretion by T-lymphocytes stimulated by imiquimod- or R-848-treated LC was increased compared to control, untreated LC. resiquimod 65-70 interferon gamma Homo sapiens 0-9 10603404-10 2000 The lymphocyte response to GBS was also strikingly different from that to LPS in that both secreted IFN-gamma and IL-12 was detected, while LPS failed to induce production of these critical cytokines. gbs 27-30 interferon gamma Homo sapiens 100-109 10603404-11 2000 This suggests an important role for TNF-alpha, IFN-gamma, and IL-12 in GBS pathogenesis and/or immunity. gbs 71-74 interferon gamma Homo sapiens 47-56 11218945-4 2000 The degree of activation of Th1-lymphocytes is responsible for the production of interferon-gamma and interleukin-2, which stimulate neopterin production in human macrophages. Neopterin 133-142 interferon gamma Homo sapiens 81-97 10629458-8 2000 A small decrease in IFN-gamma production and an increase in IL-10, IL-4, and IL-5 production were also observed with norepinephrine. Norepinephrine 117-131 interferon gamma Homo sapiens 20-29 10821443-2 2000 During immune response, interferon-gamma stimulates indoleamine 2,3-dioxygenase (IDO) converting tryptophan to N-formylkynurenine followed by kynurenine in an ensuing step. Tryptophan 97-107 interferon gamma Homo sapiens 24-40 10620119-10 2000 Tumor necrosis factor-alpha induced production of C3 and interferon-gamma induced production of factor B were inhibited by cycloheximide. Cycloheximide 123-136 interferon gamma Homo sapiens 57-73 10756442-0 2000 [Suppressive action of erythromycin on cultured tracheal epithelial cell chloride channel activated by interferon-gamma]. Erythromycin 23-35 interferon gamma Homo sapiens 103-119 10821443-2 2000 During immune response, interferon-gamma stimulates indoleamine 2,3-dioxygenase (IDO) converting tryptophan to N-formylkynurenine followed by kynurenine in an ensuing step. Kynurenine 119-129 interferon gamma Homo sapiens 24-40 10821443-2 2000 During immune response, interferon-gamma stimulates indoleamine 2,3-dioxygenase (IDO) converting tryptophan to N-formylkynurenine followed by kynurenine in an ensuing step. N'-formylkynurenine 111-129 interferon gamma Homo sapiens 24-40 11452226-5 2000 RESULTS: We found that 1) noradrenaline, 10-5 M, 10-6 M, and 10-7 M, significantly suppressed the production of IFNgamma and that noradrenaline, 10-5 M, significantly enhanced the production of IL-10. Norepinephrine 26-39 interferon gamma Homo sapiens 112-120 10781831-1 2000 PA28 is an interferon-gamma inducible modulator of proteasome function composed of two subunits, i.e. PA28alpha and PA28beta. pa28 0-4 interferon gamma Homo sapiens 11-27 10754403-6 2000 The anti-inflammatory cytokine IFN-beta blocked cytokine (IL-1beta plus IFN-gamma)-induced inhibition of glutamate uptake with a corresponding reduction in nitric oxide generation. Glutamic Acid 105-114 interferon gamma Homo sapiens 72-81 10754403-6 2000 The anti-inflammatory cytokine IFN-beta blocked cytokine (IL-1beta plus IFN-gamma)-induced inhibition of glutamate uptake with a corresponding reduction in nitric oxide generation. Nitric Oxide 156-168 interferon gamma Homo sapiens 72-81 11452226-9 2000 CONCLUSIONS: 1) noradrenaline has significant negative immunoregulatory effects in humans through enhancing the production of IL-10 and suppressing that of IFNgamma; and 2) the suppression of the production of IFNgamma is in part related to alpha2-adrenoceptor activation. Norepinephrine 16-29 interferon gamma Homo sapiens 156-171 11452226-9 2000 CONCLUSIONS: 1) noradrenaline has significant negative immunoregulatory effects in humans through enhancing the production of IL-10 and suppressing that of IFNgamma; and 2) the suppression of the production of IFNgamma is in part related to alpha2-adrenoceptor activation. Norepinephrine 16-29 interferon gamma Homo sapiens 156-164 11452226-6 2000 Clonidine, 10-5 M and 10-7 M, significantly suppressed the production of IFNgamma. Clonidine 0-9 interferon gamma Homo sapiens 73-81 11452226-7 2000 Noradrenaline, 10-5 M and 10-6 M, and clonidine, 10-5 M, significantly suppressed the IFNgamma/IL-10 production ratio. Norepinephrine 0-13 interferon gamma Homo sapiens 86-94 11452226-7 2000 Noradrenaline, 10-5 M and 10-6 M, and clonidine, 10-5 M, significantly suppressed the IFNgamma/IL-10 production ratio. Clonidine 38-47 interferon gamma Homo sapiens 86-94 10939283-6 2000 Intracellular NAD levels also increased significantly after treatment with IFN-gamma in the presence of a PARP inhibitor. NAD 14-17 interferon gamma Homo sapiens 75-84 10939283-7 2000 Pretreatment of astroglial cells with IFN-gamma significantly moderated both the drop in intracellular NAD concentration and cell death following exposure to hydrogen peroxide. NAD 103-106 interferon gamma Homo sapiens 38-47 10939283-7 2000 Pretreatment of astroglial cells with IFN-gamma significantly moderated both the drop in intracellular NAD concentration and cell death following exposure to hydrogen peroxide. Hydrogen Peroxide 158-175 interferon gamma Homo sapiens 38-47 10572065-5 1999 BEAS-2B constitutively expressed IL-16 messenger RNA (mRNA) and protein; IL-16 expression was significantly upregulated in a concentration-dependent manner within 24 h by stimulation with histamine, IL-1beta, or tumor necrosis factor (TNF)-alpha whereas interferon-gamma did not significantly increase IL-16. Histamine 188-197 interferon gamma Homo sapiens 254-270 10733169-6 2000 Co-administration of rIL-12 with F/AlOH was also associated with diminished protein-specific IgE titers, elevated neutralizing antibody titers, and interferon-gamma and (IFN-gamma) in the sera, and enhanced antigen-dependent killer cell activity in the lungs after challenge. aloh 35-39 interferon gamma Homo sapiens 148-164 10733169-6 2000 Co-administration of rIL-12 with F/AlOH was also associated with diminished protein-specific IgE titers, elevated neutralizing antibody titers, and interferon-gamma and (IFN-gamma) in the sera, and enhanced antigen-dependent killer cell activity in the lungs after challenge. aloh 35-39 interferon gamma Homo sapiens 170-179 12567463-5 2000 The cytokine levels induced by both antigens were increased significantly after praziqantel treatment especially IL-5 and IFN-gamma. praziqantel 80-91 interferon gamma Homo sapiens 122-131 12567684-6 2000 RESULTS: IFN-gamma levels induced by both SEA and SWAP were increased significantly after praziquantel treatment. Praziquantel 90-102 interferon gamma Homo sapiens 9-18 10585882-1 1999 The signalling mechanisms responsible for the hydrolysis of sphingomyelin mediated by 1,25-dihydroxyvitamin D(3) [1, 25(OH)(2)D(3)] and interferon gamma (IFN-gamma) in HL-60 cells were investigated. Sphingomyelins 60-73 interferon gamma Homo sapiens 136-163 10585882-2 1999 IFN-gamma was found to increase selectively the activity of cytosolic, Mg(2+)-independent, neutral sphingomyelinase. magnesium ion 71-77 interferon gamma Homo sapiens 0-9 10585882-3 1999 The treatment of HL-60 cells with the combination of 1,25(OH)(2)D(3) and IFN-gamma had an additive effect on sphingomyelin hydrolysis, ceramide release and the activity of cytosolic, Mg(2+)-independent, neutral sphingomyelinase. Ceramides 135-143 interferon gamma Homo sapiens 73-82 10585882-4 1999 The pretreatment of HL-60 cells with staurosporine, chelerythrine chloride and bisindolylmaleimide abolished the activity of sphingomyelinase in response to 1,25(OH)(2)D(3) and IFN-gamma. Staurosporine 37-50 interferon gamma Homo sapiens 177-186 10585882-4 1999 The pretreatment of HL-60 cells with staurosporine, chelerythrine chloride and bisindolylmaleimide abolished the activity of sphingomyelinase in response to 1,25(OH)(2)D(3) and IFN-gamma. chelerythrine 52-74 interferon gamma Homo sapiens 177-186 10585882-4 1999 The pretreatment of HL-60 cells with staurosporine, chelerythrine chloride and bisindolylmaleimide abolished the activity of sphingomyelinase in response to 1,25(OH)(2)D(3) and IFN-gamma. bisindolylmaleimide 79-98 interferon gamma Homo sapiens 177-186 10585882-5 1999 Calphostin C, which acts on the regulatory site of protein kinase C (PKC), and Go 6976, a selective inhibitor of Ca(2+)-dependent PKC isoforms, inhibited the effect of 1,25(OH)(2)D(3) but had no effect on the IFN-gamma-mediated increase in activity of sphingomyelinase. Go 6976 79-86 interferon gamma Homo sapiens 209-218 11341466-0 2000 Human interferon-gamma enhances expression of ganglioside GM2 on human lung cancer cells and their susceptibility for antiganglioside GM2 monoclonal antibody-dependent cellular cytotoxicity. Gangliosides 46-57 interferon gamma Homo sapiens 6-22 11341466-0 2000 Human interferon-gamma enhances expression of ganglioside GM2 on human lung cancer cells and their susceptibility for antiganglioside GM2 monoclonal antibody-dependent cellular cytotoxicity. gm2 58-61 interferon gamma Homo sapiens 6-22 11341466-0 2000 Human interferon-gamma enhances expression of ganglioside GM2 on human lung cancer cells and their susceptibility for antiganglioside GM2 monoclonal antibody-dependent cellular cytotoxicity. gm2 134-137 interferon gamma Homo sapiens 6-22 11341466-2 2000 In this study, we demonstrated that human interferon-gamma (HuIFN-gamma) enhanced the expression of ganglioside GM2 (GM2), which is a kind of tumor-associated antigen substantially expressed in human lung cancer and that human lung cancer cells expressing GM2 became more susceptible to anti-GM2 monoclonal antibody (mAb)-dependent tumor cell killing mediated by human effector cells after HuIFN-gamma treatment. Gangliosides 100-111 interferon gamma Homo sapiens 42-58 11341466-2 2000 In this study, we demonstrated that human interferon-gamma (HuIFN-gamma) enhanced the expression of ganglioside GM2 (GM2), which is a kind of tumor-associated antigen substantially expressed in human lung cancer and that human lung cancer cells expressing GM2 became more susceptible to anti-GM2 monoclonal antibody (mAb)-dependent tumor cell killing mediated by human effector cells after HuIFN-gamma treatment. gm2 112-115 interferon gamma Homo sapiens 42-58 11341466-2 2000 In this study, we demonstrated that human interferon-gamma (HuIFN-gamma) enhanced the expression of ganglioside GM2 (GM2), which is a kind of tumor-associated antigen substantially expressed in human lung cancer and that human lung cancer cells expressing GM2 became more susceptible to anti-GM2 monoclonal antibody (mAb)-dependent tumor cell killing mediated by human effector cells after HuIFN-gamma treatment. gm2 117-120 interferon gamma Homo sapiens 42-58 11341466-2 2000 In this study, we demonstrated that human interferon-gamma (HuIFN-gamma) enhanced the expression of ganglioside GM2 (GM2), which is a kind of tumor-associated antigen substantially expressed in human lung cancer and that human lung cancer cells expressing GM2 became more susceptible to anti-GM2 monoclonal antibody (mAb)-dependent tumor cell killing mediated by human effector cells after HuIFN-gamma treatment. gm2 117-120 interferon gamma Homo sapiens 42-58 11341466-2 2000 In this study, we demonstrated that human interferon-gamma (HuIFN-gamma) enhanced the expression of ganglioside GM2 (GM2), which is a kind of tumor-associated antigen substantially expressed in human lung cancer and that human lung cancer cells expressing GM2 became more susceptible to anti-GM2 monoclonal antibody (mAb)-dependent tumor cell killing mediated by human effector cells after HuIFN-gamma treatment. gm2 117-120 interferon gamma Homo sapiens 42-58 11341466-10 2000 Anti-GM2 mAb-dependent ADCC activities induced by lymphocytes and monocytes were more potent against IFN-gamma-treated SBC-3 and A549 cells than nontreated cells. gm2 5-8 interferon gamma Homo sapiens 101-110 10608863-2 1999 When phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) are topically applied, prominent epidermal thickening occurs, and exposure to interferon (IFN)-gamma promotes increased epidermal thickness producing psoriatic lesions. Phorbol Esters 5-19 interferon gamma Homo sapiens 149-171 10608863-2 1999 When phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) are topically applied, prominent epidermal thickening occurs, and exposure to interferon (IFN)-gamma promotes increased epidermal thickness producing psoriatic lesions. Tetradecanoylphorbol Acetate 28-64 interferon gamma Homo sapiens 149-171 10608863-2 1999 When phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) are topically applied, prominent epidermal thickening occurs, and exposure to interferon (IFN)-gamma promotes increased epidermal thickness producing psoriatic lesions. Tetradecanoylphorbol Acetate 66-69 interferon gamma Homo sapiens 149-171 10628538-2 1999 We have studied spectroscopically the dimer-monomer dissociation equilibrium of human recombinant IFN-gamma and have found that the monomers possess approximately 50% lower Trp quantum yield than the dimers [Boteva et al. Tryptophan 173-176 interferon gamma Homo sapiens 98-107 10600341-4 1999 We found that glutamine at an optimal concentration (0.6 mM) significantly enhanced PHA-stimulated lymphocyte proliferation as well as Th1 [interferon-gamma (IFN-gamma) and interleukin-2 (IL-2)] and Th2 cytokine (IL-4 and IL-10) production. Glutamine 14-23 interferon gamma Homo sapiens 140-156 10632363-8 1999 Furthermore, FBP peptides induced E39-specific CTLs and E39- and E41-specific IFN-gamma and IP-10 secretion in certain healthy donors. Peptides 17-25 interferon gamma Homo sapiens 78-87 10600341-6 1999 Interestingly, addition of glutamine promoted the BCG-elicited Th1 cytokine response (IFN-gamma), but suppressed the measles-induced Th2 cytokine response (IL-10). Glutamine 27-36 interferon gamma Homo sapiens 86-95 10594549-4 1999 Further, IFN-gamma induced tyrosine phosphorylation of JAK2 in eosinophils, as indicated by Western blot analysis. Tyrosine 27-35 interferon gamma Homo sapiens 9-18 10594549-5 1999 Finally, the specific JAK2 inhibitor AG-490 inhibited the tyrosine phosphorylation of JAK2, IFN-gamma-induced survival and CD69 expression in eosinophils. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 37-43 interferon gamma Homo sapiens 92-101 10594549-5 1999 Finally, the specific JAK2 inhibitor AG-490 inhibited the tyrosine phosphorylation of JAK2, IFN-gamma-induced survival and CD69 expression in eosinophils. Tyrosine 58-66 interferon gamma Homo sapiens 92-101 10600341-4 1999 We found that glutamine at an optimal concentration (0.6 mM) significantly enhanced PHA-stimulated lymphocyte proliferation as well as Th1 [interferon-gamma (IFN-gamma) and interleukin-2 (IL-2)] and Th2 cytokine (IL-4 and IL-10) production. Glutamine 14-23 interferon gamma Homo sapiens 158-167 10669119-5 1999 In monocytes the IFNgamma-induced increase in accessory function is prevented only by cyclosporine A (17 +/- 7%) and dexamethasone (59 +/- 9%). Cyclosporine 86-100 interferon gamma Homo sapiens 17-25 10568827-1 1999 The cytotoxic effect of 5-FU has been shown by the induction of apoptosis in cancer cells, and reported to be enhanced by IFN-gamma. Fluorouracil 24-28 interferon gamma Homo sapiens 122-131 10601128-5 1999 Salicylate treatment inhibited iNOS expression induced by TNF-alpha and IFN-gamma and attenuated the phosphorylation of ERK by TNF-alpha and IFN-gamma either alone or in combination. Salicylates 0-10 interferon gamma Homo sapiens 72-81 10601128-5 1999 Salicylate treatment inhibited iNOS expression induced by TNF-alpha and IFN-gamma and attenuated the phosphorylation of ERK by TNF-alpha and IFN-gamma either alone or in combination. Salicylates 0-10 interferon gamma Homo sapiens 141-150 10669119-5 1999 In monocytes the IFNgamma-induced increase in accessory function is prevented only by cyclosporine A (17 +/- 7%) and dexamethasone (59 +/- 9%). Dexamethasone 117-130 interferon gamma Homo sapiens 17-25 10613098-2 1999 Lipopolysaccarides and cytokines, like tumor necrosis factor, interleukin-1 and interferon-gamma, have been shown to induce iNOS in the endothelium, vascular smooth muscle cells, macrophages and different parenchymal cells. lipopolysaccarides 0-18 interferon gamma Homo sapiens 80-96 10545071-1 1999 BACKGROUND: Neopterin, produced by human monocytes/macrophages upon stimulation by interferon-gamma, is a sensitive marker for monitoring Th1-cell immune response in humans. Neopterin 12-21 interferon gamma Homo sapiens 83-99 10533055-6 1999 Similarly, the effect of the NOS inhibitor, N(G)-monomethyl L-arginine (NMMA) on IL-1beta/IFNgamma-induced neuronal death was variable, showing no statistically significant effect when results from more than 30 independent cultures were averaged. omega-N-Methylarginine 44-70 interferon gamma Homo sapiens 90-98 10596698-6 1999 Suppressed expression of IL-3 (36.9%), IL4 (38.8%), GM-CSF (24.6%) and IFN-gamma (37.7%), but not of IL-5, was only seen with theophylline at a concentration of 10(-3) M (180 microg x mL(-1)) (p<0.05) and not at lower concentrations. Theophylline 126-138 interferon gamma Homo sapiens 71-80 10596698-7 1999 In contrast, dexamethasone caused a dose-dependent suppression of transcription of all cytokines, with 39.5% for IL-3, 84.4% for IL-4, 40.6% for IL-5, 50.9% for GM-CSF and 31.8% for IFN-gamma at 10(-6) M (390 ng x mL(-1)) (p<0.05-0.001). Dexamethasone 13-26 interferon gamma Homo sapiens 182-191 10533055-6 1999 Similarly, the effect of the NOS inhibitor, N(G)-monomethyl L-arginine (NMMA) on IL-1beta/IFNgamma-induced neuronal death was variable, showing no statistically significant effect when results from more than 30 independent cultures were averaged. omega-N-Methylarginine 72-76 interferon gamma Homo sapiens 90-98 10569698-0 1999 Histamine and histamine-receptor antagonists modify gene expression and biosynthesis of interferon gamma in peripheral human blood mononuclear cells and in CD19-depleted cell subsets. Histamine 0-9 interferon gamma Homo sapiens 88-104 10569633-5 1999 This revealed that IL-1 and LPS did not induce any increase in the amount of intracellular peroxides by themselves, but they primed IFN-gamma for maximal induction of peroxides. Peroxides 167-176 interferon gamma Homo sapiens 132-141 10569633-6 1999 The intracellular amount of peroxides was highly increased on stimulation with IFN-gamma, IL-1, and LPS, and it was strongly inhibited by catalase. Peroxides 28-37 interferon gamma Homo sapiens 79-88 10569633-11 1999 Finally, it has been also shown for the first time that IFN-gamma stimulation induces production of peroxides in human and murine hepatocyte cell lines. Peroxides 100-109 interferon gamma Homo sapiens 56-65 10545486-6 1999 IL-2 and IFN-gamma exerted a dose-dependent inhibition on spontaneous as well as CD40- and cytokine-induced IgD production by PBMC, but not by tonsil mononuclear cells. PBMC 126-130 interferon gamma Homo sapiens 9-18 10547183-1 1999 Neopterin and 7,8-dihydroneopterin are released by human monocytes/macrophages upon stimulation with interferon-gamma. Neopterin 0-9 interferon gamma Homo sapiens 101-117 10547183-1 1999 Neopterin and 7,8-dihydroneopterin are released by human monocytes/macrophages upon stimulation with interferon-gamma. 7,8-dihydroneopterin 14-34 interferon gamma Homo sapiens 101-117 10531207-10 1999 This conclusion was supported by evidence that N(G)-monomethyl-L-arginine, a competitive inhibitor of inducible NOS activity, is able to block the inhibitory action of IL-1 on IFN-gamma-induced bacteriostasis. omega-N-Methylarginine 47-73 interferon gamma Homo sapiens 176-185 10583599-0 1999 Nitric oxide selectively decreases interferon-gamma expression by activated human T lymphocytes via a cGMP-independent mechanism. Nitric Oxide 0-12 interferon gamma Homo sapiens 35-51 10583599-0 1999 Nitric oxide selectively decreases interferon-gamma expression by activated human T lymphocytes via a cGMP-independent mechanism. Cyclic GMP 102-106 interferon gamma Homo sapiens 35-51 10583599-1 1999 The role of exogenous nitric oxide (NO) on the expression of interleukin (IL)-2, IL-4, IL-5 and interferon-gamma (IFN-gamma) by freshly isolated human T lymphocytes was investigated. Nitric Oxide 22-34 interferon gamma Homo sapiens 96-112 10569698-6 1999 These results suggest, that inhibition of IFNgamma gene expression by histamine is a direct effect of histamine on H2 receptor of T lymphocytes; however, the superinduction of IFNgamma by cimetidine requires the presence of other (probably primarily B) cell subsets. Histamine 70-79 interferon gamma Homo sapiens 42-50 10569698-6 1999 These results suggest, that inhibition of IFNgamma gene expression by histamine is a direct effect of histamine on H2 receptor of T lymphocytes; however, the superinduction of IFNgamma by cimetidine requires the presence of other (probably primarily B) cell subsets. Histamine 102-111 interferon gamma Homo sapiens 42-50 10569698-6 1999 These results suggest, that inhibition of IFNgamma gene expression by histamine is a direct effect of histamine on H2 receptor of T lymphocytes; however, the superinduction of IFNgamma by cimetidine requires the presence of other (probably primarily B) cell subsets. Cimetidine 188-198 interferon gamma Homo sapiens 42-50 10569698-6 1999 These results suggest, that inhibition of IFNgamma gene expression by histamine is a direct effect of histamine on H2 receptor of T lymphocytes; however, the superinduction of IFNgamma by cimetidine requires the presence of other (probably primarily B) cell subsets. Cimetidine 188-198 interferon gamma Homo sapiens 176-184 10583599-1 1999 The role of exogenous nitric oxide (NO) on the expression of interleukin (IL)-2, IL-4, IL-5 and interferon-gamma (IFN-gamma) by freshly isolated human T lymphocytes was investigated. Nitric Oxide 22-34 interferon gamma Homo sapiens 114-123 10583599-4 1999 Using the guanylate cyclase inhibitor, LY83583, it was shown that the inhibition of IL-4 and IL-5 was cGMP dependent, whereas additional mechanisms mediated the inhibition of IFN-gamma. 6-anilino-5,8-quinolinedione 39-46 interferon gamma Homo sapiens 175-184 10583599-5 1999 Exposure of T cells to the NO-donor compounds for 24 hr prior to stimulation resulted in a more pronounced inhibition of IFN-gamma secretion by DPTA and DETA (P < 0.01), despite the fact that NO generation could no longer be detected. diphtheria toxin fragment A 144-148 interferon gamma Homo sapiens 121-130 10584203-1 1999 Taxol, an antineoplastic drug, increases the fraction of cells in G2/M phases of cell cycle, induces apoptosis of leukemic cells, and activates macrophages to produce nitric oxide (NO) in response to interferon-gamma. Paclitaxel 0-5 interferon gamma Homo sapiens 200-216 10584203-1 1999 Taxol, an antineoplastic drug, increases the fraction of cells in G2/M phases of cell cycle, induces apoptosis of leukemic cells, and activates macrophages to produce nitric oxide (NO) in response to interferon-gamma. Nitric Oxide 167-179 interferon gamma Homo sapiens 200-216 10569698-1 1999 The effect of histamine and histamine antagonists was examined on gene expression and biosynthesis of bacterial endotoxin (LPS) induced interferon gamma (IFNgamma) both in human peripheral mononuclear cells (PMBC) and in T-cell enriched fractions. Histamine 14-23 interferon gamma Homo sapiens 136-163 10583599-5 1999 Exposure of T cells to the NO-donor compounds for 24 hr prior to stimulation resulted in a more pronounced inhibition of IFN-gamma secretion by DPTA and DETA (P < 0.01), despite the fact that NO generation could no longer be detected. DEET 153-157 interferon gamma Homo sapiens 121-130 10583599-10 1999 These data show that NO can modulate the balance between the expression, by human T-lymphocytes, of T helper 1- and T helper 2-type cytokines, through selective and persistent inhibition of the expression of IFN-gamma via a cGMP-independent mechanism. Cyclic GMP 224-228 interferon gamma Homo sapiens 208-217 10569698-1 1999 The effect of histamine and histamine antagonists was examined on gene expression and biosynthesis of bacterial endotoxin (LPS) induced interferon gamma (IFNgamma) both in human peripheral mononuclear cells (PMBC) and in T-cell enriched fractions. Histamine 28-37 interferon gamma Homo sapiens 136-163 10583616-6 1999 Increased IFN-gamma release was observed following an in vitro challenge of the patient"s lymphocytes with allopurinol, but not following in vitro challenge with colchicine. Allopurinol 107-118 interferon gamma Homo sapiens 10-19 10569698-1 1999 The effect of histamine and histamine antagonists was examined on gene expression and biosynthesis of bacterial endotoxin (LPS) induced interferon gamma (IFNgamma) both in human peripheral mononuclear cells (PMBC) and in T-cell enriched fractions. pmbc 208-212 interferon gamma Homo sapiens 136-163 10583616-8 1999 CONCLUSIONS: The role of allopurinol as the drug responsible for the induction of Stevens-Johnson syndrome in our patient was confirmed by in vitro allopurinol-induced IFN-gamma release, which may indicate a drug-specific immune response. Allopurinol 25-36 interferon gamma Homo sapiens 168-177 10583616-8 1999 CONCLUSIONS: The role of allopurinol as the drug responsible for the induction of Stevens-Johnson syndrome in our patient was confirmed by in vitro allopurinol-induced IFN-gamma release, which may indicate a drug-specific immune response. Allopurinol 148-159 interferon gamma Homo sapiens 168-177 10569698-2 1999 We found, that histamine inhibited the LPS induced transcription of IFNgamma gene and biosynthesis of IFNgamma protein in PMBC and also in CD19-depleted cell populations. Histamine 15-24 interferon gamma Homo sapiens 68-76 10598882-5 1999 Hypothemycin also inhibited IL-6, IL-10, IFN-gamma and TNF-alpha production. hypothemycin 0-12 interferon gamma Homo sapiens 41-50 10569698-2 1999 We found, that histamine inhibited the LPS induced transcription of IFNgamma gene and biosynthesis of IFNgamma protein in PMBC and also in CD19-depleted cell populations. Histamine 15-24 interferon gamma Homo sapiens 102-110 10569698-3 1999 The inhibitory effect of histamine could be reversed by the H2 histamine receptor (HR2) antagonists cimetidine and ranitidine both in PMBC and in CD19-depleted cells, but not with triprolidine, an H1 receptor antagonist, suggesting that the inhibition of IFNgamma production is mediated through H2 receptors in these cell populations. Histamine 25-34 interferon gamma Homo sapiens 255-263 10569698-3 1999 The inhibitory effect of histamine could be reversed by the H2 histamine receptor (HR2) antagonists cimetidine and ranitidine both in PMBC and in CD19-depleted cells, but not with triprolidine, an H1 receptor antagonist, suggesting that the inhibition of IFNgamma production is mediated through H2 receptors in these cell populations. Cimetidine 100-110 interferon gamma Homo sapiens 255-263 10569698-3 1999 The inhibitory effect of histamine could be reversed by the H2 histamine receptor (HR2) antagonists cimetidine and ranitidine both in PMBC and in CD19-depleted cells, but not with triprolidine, an H1 receptor antagonist, suggesting that the inhibition of IFNgamma production is mediated through H2 receptors in these cell populations. Ranitidine 115-125 interferon gamma Homo sapiens 255-263 10569698-4 1999 In contrast to the inhibitory effect of histamine, cimetidine alone (in the absence of exogenous histamine) strongly stimulated both the IFNgamma mRNA and protein production, whereas this effect was hardly seen by and other H2 receptor blocker, ranitidine. Cimetidine 51-61 interferon gamma Homo sapiens 137-145 10569698-5 1999 This superinduction of IFNgamma gene by cimetidine disappeared if the CD19+ cells are removed from PMBC. Cimetidine 40-50 interferon gamma Homo sapiens 23-31 10571732-6 1999 Human keratinocyte-secreted interleukin-18 is biologically active, in that conditioned media from phorbol 12-myrisate 13-acetate, lipopolysaccharide and DNCB-treated human keratinocytes induce interferon-gamma expression by peripheral blood mononuclear cells. phorbol 12-myrisate 13-acetate 98-128 interferon gamma Homo sapiens 193-209 10571732-6 1999 Human keratinocyte-secreted interleukin-18 is biologically active, in that conditioned media from phorbol 12-myrisate 13-acetate, lipopolysaccharide and DNCB-treated human keratinocytes induce interferon-gamma expression by peripheral blood mononuclear cells. Dinitrochlorobenzene 153-157 interferon gamma Homo sapiens 193-209 10523612-6 1999 Antisense oligodeoxynucleotide of Txk specifically inhibited IFN-gamma production of normal peripheral blood lymphocytes, antigen-specific Th1 clones, and Th0 clones; IL-2 and IL-4 production by the T cells was unaffected. Oligodeoxyribonucleotides 10-30 interferon gamma Homo sapiens 61-70 10566657-0 1999 Effect of radioactive iodine therapy on cytokine production in Graves" disease: transient increases in interleukin-4 (IL-4), IL-6, IL-10, and tumor necrosis factor-alpha, with longer term increases in interferon-gamma production. radioactive iodine 10-28 interferon gamma Homo sapiens 201-217 10566657-6 1999 Thus, radioiodine treatment induced a transient increase in both proinflammatory and antiinflammatory cytokines and a more prolonged increase in IFNgamma production, the latter representing a definite shift toward a type 1 cytokine profile. Iodine-131 6-17 interferon gamma Homo sapiens 145-153 10518672-3 1999 Aerosolized IFN-gamma was recovered in PBS solution by bubbling and its concentration was determined. Lead 39-42 interferon gamma Homo sapiens 12-21 10518672-4 1999 After nebulization for 30 min, aerosolized IFN-gamma was detected only 0.4+/-0.2% of the initial amount in the PBS solution and 3.1+/-0.7% in the reservoir. Lead 111-114 interferon gamma Homo sapiens 43-52 10518672-7 1999 Liposome prepared from distearoyl phosphatidylcholine (DSPC) or hydrogenated soy phosphatidylcholine (HSPC) was very effective for stabilization of aerosolized IFN-gamma (DSPC/DPPG=10/1, HSPC/DSPG=10/1). 1,2-distearoyllecithin 23-53 interferon gamma Homo sapiens 160-169 10518672-7 1999 Liposome prepared from distearoyl phosphatidylcholine (DSPC) or hydrogenated soy phosphatidylcholine (HSPC) was very effective for stabilization of aerosolized IFN-gamma (DSPC/DPPG=10/1, HSPC/DSPG=10/1). 1,2-distearoyllecithin 55-59 interferon gamma Homo sapiens 160-169 10518672-7 1999 Liposome prepared from distearoyl phosphatidylcholine (DSPC) or hydrogenated soy phosphatidylcholine (HSPC) was very effective for stabilization of aerosolized IFN-gamma (DSPC/DPPG=10/1, HSPC/DSPG=10/1). soy phosphatidylcholine 77-100 interferon gamma Homo sapiens 160-169 10518672-7 1999 Liposome prepared from distearoyl phosphatidylcholine (DSPC) or hydrogenated soy phosphatidylcholine (HSPC) was very effective for stabilization of aerosolized IFN-gamma (DSPC/DPPG=10/1, HSPC/DSPG=10/1). 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine 102-106 interferon gamma Homo sapiens 160-169 10518672-7 1999 Liposome prepared from distearoyl phosphatidylcholine (DSPC) or hydrogenated soy phosphatidylcholine (HSPC) was very effective for stabilization of aerosolized IFN-gamma (DSPC/DPPG=10/1, HSPC/DSPG=10/1). 1,2-dipalmitoylphosphatidylglycerol 176-180 interferon gamma Homo sapiens 160-169 10523304-4 1999 Regardless of this, the antiviral activities of both IFN-alpha and IFN-gamma were attenuated by SB203580. SB 203580 96-104 interferon gamma Homo sapiens 67-76 10515892-3 1999 Whereas IFNgamma and granulocyte colony-stimulating factor (G-CSF) are efficient inducers of STAT1 and STAT3 tyrosine phosphorylation in polymorphonuclear neutrophils (PMN), IL-10 fails to trigger STAT1 and STAT3 tyrosine and serine phosphorylation, therefore explaining its inability to induce the FcgammaRI expression in these cells. Tyrosine 109-117 interferon gamma Homo sapiens 8-16 10515892-3 1999 Whereas IFNgamma and granulocyte colony-stimulating factor (G-CSF) are efficient inducers of STAT1 and STAT3 tyrosine phosphorylation in polymorphonuclear neutrophils (PMN), IL-10 fails to trigger STAT1 and STAT3 tyrosine and serine phosphorylation, therefore explaining its inability to induce the FcgammaRI expression in these cells. Tyrosine 213-221 interferon gamma Homo sapiens 8-16 10515221-11 1999 In conclusion, our study clearly demonstrated that studied ex vivo, FK506 and CsA decrease the frequencies of cells expressing IL-2, IL-4 and IL-2/IFN-gamma in vivo but do not affect those expressing IFN-gamma. Tacrolimus 68-73 interferon gamma Homo sapiens 147-156 10515892-3 1999 Whereas IFNgamma and granulocyte colony-stimulating factor (G-CSF) are efficient inducers of STAT1 and STAT3 tyrosine phosphorylation in polymorphonuclear neutrophils (PMN), IL-10 fails to trigger STAT1 and STAT3 tyrosine and serine phosphorylation, therefore explaining its inability to induce the FcgammaRI expression in these cells. Serine 226-232 interferon gamma Homo sapiens 8-16 10510354-0 1999 Nitric oxide suppresses human T lymphocyte proliferation through IFN-gamma-dependent and IFN-gamma-independent induction of apoptosis. Nitric Oxide 0-12 interferon gamma Homo sapiens 65-74 10510354-0 1999 Nitric oxide suppresses human T lymphocyte proliferation through IFN-gamma-dependent and IFN-gamma-independent induction of apoptosis. Nitric Oxide 0-12 interferon gamma Homo sapiens 89-98 10510366-5 1999 In this paper we present evidence that cultured LPMC secrete a factor which acts on preactivated T cells in concert with TNF-alpha to augment IFN-gamma production. lpmc 48-52 interferon gamma Homo sapiens 142-151 10510366-7 1999 Peripheral blood PHA-activated T cells incubated in supernatants from LPMC became responsive to TNF-alpha by increasing IFN-gamma output upon stimulation. lpmc 70-74 interferon gamma Homo sapiens 120-129 10510377-3 1999 Polarized RAW264.7 macrophages and human neutrophils and monocytes exhibited NAD(P)H autofluorescence oscillation periods of congruent with20 s. IFN-gamma tripled the NAD(P)H oscillatory amplitude for these cells. nad(p)h 77-84 interferon gamma Homo sapiens 145-154 10510377-3 1999 Polarized RAW264.7 macrophages and human neutrophils and monocytes exhibited NAD(P)H autofluorescence oscillation periods of congruent with20 s. IFN-gamma tripled the NAD(P)H oscillatory amplitude for these cells. nad(p)h 167-174 interferon gamma Homo sapiens 145-154 10536887-12 1999 Clones derived 4 h after saline challenge showed strong mRNA signals for IL-13, IL-4, and IFN-gamma, whereas clones derived 24 h after allergen challenge expressed IL-13, GM-CSF, IL-3, IL-4, and often IL-5 (i.e., closer to the Th2 profile). Sodium Chloride 25-31 interferon gamma Homo sapiens 90-99 10540154-0 1999 Sodium butyrate blocks interferon-gamma (IFN-gamma)-induced biosynthesis of MHC class III gene products (complement C4 and factor B) in human fetal intestinal epithelial cells. Butyric Acid 0-15 interferon gamma Homo sapiens 23-50 10540154-4 1999 However, sodium butyrate dose-dependently inhibited IFN-gamma-induced C4 and factor B secretion. Butyric Acid 9-24 interferon gamma Homo sapiens 52-61 10540154-8 1999 IFN-gamma and sodium butyrate induced a counter-regulatory effect on C4 and factor B secretion: IFN-gamma acted as a potent inducer, but sodium butyrate potently abrogated these responses. Butyric Acid 14-29 interferon gamma Homo sapiens 96-105 10540154-8 1999 IFN-gamma and sodium butyrate induced a counter-regulatory effect on C4 and factor B secretion: IFN-gamma acted as a potent inducer, but sodium butyrate potently abrogated these responses. Butyric Acid 137-152 interferon gamma Homo sapiens 0-9 10540171-5 1999 We observed that low doses of MTX strongly suppress TNF and to a lesser extent interferon-gamma (IFN-gamma) production by T cells from both healthy donors and RA patients when present during T cell priming via the TCR. Methotrexate 30-33 interferon gamma Homo sapiens 79-95 10540171-5 1999 We observed that low doses of MTX strongly suppress TNF and to a lesser extent interferon-gamma (IFN-gamma) production by T cells from both healthy donors and RA patients when present during T cell priming via the TCR. Methotrexate 30-33 interferon gamma Homo sapiens 97-106 10548215-1 1999 OBJECTIVE: Incubation of enterocytic monolayers with interferon (IFN)-gamma increases nitric oxide (NO) production and permeability, but NO synthesis inhibitors ameliorate the development of IFN-gamma-induced hyperpermeability. Nitric Oxide 86-98 interferon gamma Homo sapiens 53-75 10515221-11 1999 In conclusion, our study clearly demonstrated that studied ex vivo, FK506 and CsA decrease the frequencies of cells expressing IL-2, IL-4 and IL-2/IFN-gamma in vivo but do not affect those expressing IFN-gamma. Cyclosporine 78-81 interferon gamma Homo sapiens 147-156 10540337-5 1999 Here we describe experiments in which the L-tryptophan analog, 6-chloro-DL-tryptophan (CDLT) caused a dose-dependent inhibition in the IFN-gamma-induced IDO-mediated L-tryptophan degradation in monocyte-derived macrophages and glioblastoma cells. Tryptophan 42-54 interferon gamma Homo sapiens 135-144 10540337-5 1999 Here we describe experiments in which the L-tryptophan analog, 6-chloro-DL-tryptophan (CDLT) caused a dose-dependent inhibition in the IFN-gamma-induced IDO-mediated L-tryptophan degradation in monocyte-derived macrophages and glioblastoma cells. Tryptophan 73-85 interferon gamma Homo sapiens 135-144 10540337-5 1999 Here we describe experiments in which the L-tryptophan analog, 6-chloro-DL-tryptophan (CDLT) caused a dose-dependent inhibition in the IFN-gamma-induced IDO-mediated L-tryptophan degradation in monocyte-derived macrophages and glioblastoma cells. 6-chlorotryptophan 63-85 interferon gamma Homo sapiens 135-144 10540337-9 1999 IDO inhibition by CDLT in human macrophages resulted in a complete abrogation of the IFN-gamma-induced growth inhibition of streptococci and staphylococci. cdlt 18-22 interferon gamma Homo sapiens 85-94 10540337-5 1999 Here we describe experiments in which the L-tryptophan analog, 6-chloro-DL-tryptophan (CDLT) caused a dose-dependent inhibition in the IFN-gamma-induced IDO-mediated L-tryptophan degradation in monocyte-derived macrophages and glioblastoma cells. cdlt 87-91 interferon gamma Homo sapiens 135-144 10466584-0 1999 Prostaglandin E2 downregulates interferon-gamma-induced intercellular adhesion molecule-1 expression via EP2 receptors in human gingival fibroblasts. Dinoprostone 0-16 interferon gamma Homo sapiens 31-47 10466584-1 1999 In the present study, the effect of prostaglandin E2 (PGE2) on intercellular adhesion molecule-1 (ICAM-1) expression in interferon-gamma (IFN-gamma)-stimulated human gingival fibroblasts (HGF) was investigated. Dinoprostone 36-52 interferon gamma Homo sapiens 120-136 10466584-10 1999 Sulprostone, an EP1/EP3 agonist, showed stimulatory effect on ICAM-1 expression elicited by IFN-gamma. sulprostone 0-11 interferon gamma Homo sapiens 92-101 10466584-11 1999 From these results, we suggest that PGE2 downregulates IFN-gamma-induced ICAM-1 expression in HGF, primarily via EP2 receptors by cAMP-dependent signaling pathways. Dinoprostone 36-40 interferon gamma Homo sapiens 55-64 10466584-1 1999 In the present study, the effect of prostaglandin E2 (PGE2) on intercellular adhesion molecule-1 (ICAM-1) expression in interferon-gamma (IFN-gamma)-stimulated human gingival fibroblasts (HGF) was investigated. Dinoprostone 36-52 interferon gamma Homo sapiens 138-147 10466584-11 1999 From these results, we suggest that PGE2 downregulates IFN-gamma-induced ICAM-1 expression in HGF, primarily via EP2 receptors by cAMP-dependent signaling pathways. Cyclic AMP 130-134 interferon gamma Homo sapiens 55-64 10466584-1 1999 In the present study, the effect of prostaglandin E2 (PGE2) on intercellular adhesion molecule-1 (ICAM-1) expression in interferon-gamma (IFN-gamma)-stimulated human gingival fibroblasts (HGF) was investigated. Dinoprostone 54-58 interferon gamma Homo sapiens 120-136 10466584-1 1999 In the present study, the effect of prostaglandin E2 (PGE2) on intercellular adhesion molecule-1 (ICAM-1) expression in interferon-gamma (IFN-gamma)-stimulated human gingival fibroblasts (HGF) was investigated. Dinoprostone 54-58 interferon gamma Homo sapiens 138-147 10491339-0 1999 Up-regulation of nitric oxide production by interferon-gamma in cultured peritoneal macrophages from patients with cirrhosis. Nitric Oxide 17-29 interferon gamma Homo sapiens 44-60 10466584-2 1999 Addition of PGE2 to HGF inhibited ICAM-1 expression elicited by IFN-gamma. Dinoprostone 12-16 interferon gamma Homo sapiens 64-73 10466584-6 1999 An EP2/EP4 agonist, 11-deoxy-PGE1, attenuated IFN-gamma-elicited ICAM-1 expression in a concentration-dependent manner. 11-deoxyprostaglandin E1 20-33 interferon gamma Homo sapiens 46-55 10466584-8 1999 Butaprost, an EP2-selective agonist, mimicked inhibition of IFN-gamma-elicited ICAM-1 expression by 11-deoxy-PGE1. butaprost 0-9 interferon gamma Homo sapiens 60-69 10466584-8 1999 Butaprost, an EP2-selective agonist, mimicked inhibition of IFN-gamma-elicited ICAM-1 expression by 11-deoxy-PGE1. 11-deoxyprostaglandin E1 100-113 interferon gamma Homo sapiens 60-69 10466584-9 1999 An EP3 agonist, ONO-AP-324, was inert with respect to IFN-gamma-elicited ICAM-1 expression. ONO AP 324 16-26 interferon gamma Homo sapiens 54-63 10400874-0 1999 Interferon-gamma exacerbates polymethylmethacrylate particle-induced interleukin-6 release by human monocyte/macrophages in vitro. Polymethyl Methacrylate 29-51 interferon gamma Homo sapiens 0-16 10518828-8 1999 Cytokine gene expression and protein secretion into culture supernatants (IL-4, IL-5, IL-13, and IFN-gamma) were down-regulated in a concentration-dependent manner by either CS or FK in all relevant T-cell subsets. Cyclosporine 174-176 interferon gamma Homo sapiens 97-106 10505694-9 1999 Under stimulation, IFN-gamma release was lower in CU (13.42 +/- 12.04 IU/ml) than in CON, UR, and PMMA (51.84 +/- 30.74, 32.16 +/- 13.86, and 32.16 +/- 13.86 IU/ml, respectively; P < 0.01). Copper 50-52 interferon gamma Homo sapiens 19-28 10505694-9 1999 Under stimulation, IFN-gamma release was lower in CU (13.42 +/- 12.04 IU/ml) than in CON, UR, and PMMA (51.84 +/- 30.74, 32.16 +/- 13.86, and 32.16 +/- 13.86 IU/ml, respectively; P < 0.01). Urea 90-92 interferon gamma Homo sapiens 19-28 10505694-9 1999 Under stimulation, IFN-gamma release was lower in CU (13.42 +/- 12.04 IU/ml) than in CON, UR, and PMMA (51.84 +/- 30.74, 32.16 +/- 13.86, and 32.16 +/- 13.86 IU/ml, respectively; P < 0.01). pmma 98-102 interferon gamma Homo sapiens 19-28 10400874-6 1999 Exposure of the monocyte/macrophages to PMMA particles resulted in a dose-dependent release of interleukin-6 and tumor necrosis factor-alpha at 48 h. The interleukin-6 release in response to PMMA particle challenge was stimulated by 76% and 127% in the presence of 1.0 and 10.0 ng/mL of interferon-gamma, respectively. Polymethyl Methacrylate 40-44 interferon gamma Homo sapiens 287-303 10400874-4 1999 The present study examined the effects of interferon-gamma on polymethylmethacrylate (PMMA) particle-challenged monocyte/macrophages in vitro. Polymethyl Methacrylate 62-84 interferon gamma Homo sapiens 42-58 10400874-6 1999 Exposure of the monocyte/macrophages to PMMA particles resulted in a dose-dependent release of interleukin-6 and tumor necrosis factor-alpha at 48 h. The interleukin-6 release in response to PMMA particle challenge was stimulated by 76% and 127% in the presence of 1.0 and 10.0 ng/mL of interferon-gamma, respectively. Polymethyl Methacrylate 191-195 interferon gamma Homo sapiens 287-303 10400874-11 1999 The data presented in this study demonstrate that the immunologic modulator interferon-gamma exacerbates monocyte/macrophage release of the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha in response to PMMA particle challenge in vitro. Polymethyl Methacrylate 228-232 interferon gamma Homo sapiens 76-92 10479148-2 1999 IFN-gamma (from the apical pole) and IL-6 (from the basolateral pole) considerably reduced the bacterial intracellular growth, an effect largely abolished by l-monomethyl arginine. omega-N-Methylarginine 158-179 interferon gamma Homo sapiens 0-9 10457352-6 1999 In contrast, in the presence of tumor necrosis factor alpha (TNFalpha) and/or interferon gamma (IFNgamma), HIEC became highly susceptible to FAS-induced apoptosis. ammonium ferrous sulfate 141-144 interferon gamma Homo sapiens 78-105 10457352-7 1999 The sensitizing effect to FAS-induced apoptosis was mediated via TNFalpha- and IFNgamma-induced upregulation of FAS expression (maximally 348%). ammonium ferrous sulfate 26-29 interferon gamma Homo sapiens 79-87 10457352-9 1999 In colonic organ cultures, IFNgamma and TNFalpha also enhanced colonocyte FAS expression, resulting in a markedly increased apoptotic response to stimulation of this receptor, as shown by in situ terminal deosyuridine triphosphate nick-end staining. deosyuridine triphosphate 205-230 interferon gamma Homo sapiens 27-35 10490958-0 1999 Oligodeoxynucleotides containing palindrome sequences with internal 5"-CpG-3" act directly on human NK and activated T cells to induce IFN-gamma production in vitro. Oligodeoxyribonucleotides 0-21 interferon gamma Homo sapiens 135-144 10525042-7 1999 In addition, nitric oxide (NO) treatment decreased IFN-gamma induction of IP-10. Nitric Oxide 13-25 interferon gamma Homo sapiens 51-60 10479148-5 1999 Ampicillin was bacteriostatic in unstimulated cells but modestly bactericidal in cells treated with IFN-gamma and IL-6. Ampicillin 0-10 interferon gamma Homo sapiens 100-109 10532592-7 1999 Finally, IFN-gamma stimulated the Pgp transport activity in MDM, as rhodamine 123-efflux increased in treated cells as compared with control cultures. Rhodamine 123 68-81 interferon gamma Homo sapiens 9-18 10616965-8 1999 In the presence of AFL there was a reduction in the levels of secreted IFN-gamma while the production of both IL-10 and IL-4 were increased. aflatoxicol 19-22 interferon gamma Homo sapiens 71-80 10516755-8 1999 Cycloheximide, but not actinomycin D or brefeldin A, increased CD95-specific cell death only in IFNgamma-treated RS4;11 cells by approximately 12%. Cycloheximide 0-13 interferon gamma Homo sapiens 96-104 10602776-6 1999 RESULTS: We verified resistance of murine and human macrophages against NO donors such as S-nitrosoglutathione or spermine-NO by pre-exposing cells to lipophilic cAMP analogs or by pretreatment with lipopolysaccaride, interferon-gamma, and N(G)-nitroarginine-methylester for 15 hr. S-Nitrosoglutathione 90-110 interferon gamma Homo sapiens 218-234 10602776-6 1999 RESULTS: We verified resistance of murine and human macrophages against NO donors such as S-nitrosoglutathione or spermine-NO by pre-exposing cells to lipophilic cAMP analogs or by pretreatment with lipopolysaccaride, interferon-gamma, and N(G)-nitroarginine-methylester for 15 hr. Spermine 114-122 interferon gamma Homo sapiens 218-234 10510970-3 1999 Recent evidence showed that the induction of indoleamine 2,3 dioxygenase (IDO) by interferon-gamma (IFN-gamma) inhibited growth of group B streptococci by depleting the essential amino acid L-tryptophan. essential amino acid l-tryptophan 169-202 interferon gamma Homo sapiens 82-98 10510970-3 1999 Recent evidence showed that the induction of indoleamine 2,3 dioxygenase (IDO) by interferon-gamma (IFN-gamma) inhibited growth of group B streptococci by depleting the essential amino acid L-tryptophan. essential amino acid l-tryptophan 169-202 interferon gamma Homo sapiens 100-109 10510970-4 1999 This study describes the IFN-gamma-induced expression of IDO -- shown at a transcriptional level by Northern blot analysis, at translational level by Western blot and also at a functional level by L-tryptophan degradation to L-kynurenine -- in the uro-epithelial cell line RT4. Tryptophan 197-209 interferon gamma Homo sapiens 25-34 10510970-4 1999 This study describes the IFN-gamma-induced expression of IDO -- shown at a transcriptional level by Northern blot analysis, at translational level by Western blot and also at a functional level by L-tryptophan degradation to L-kynurenine -- in the uro-epithelial cell line RT4. Kynurenine 225-237 interferon gamma Homo sapiens 25-34 10510970-6 1999 Multiresistant enterococci, including vancomycin-resistant strains resistant to all commercially available antibiotics, were inhibited by the IFN-gamma-induced expression of IDO and subsequent L-tryptophan degradation. Vancomycin 38-48 interferon gamma Homo sapiens 142-151 10510970-6 1999 Multiresistant enterococci, including vancomycin-resistant strains resistant to all commercially available antibiotics, were inhibited by the IFN-gamma-induced expression of IDO and subsequent L-tryptophan degradation. Tryptophan 193-205 interferon gamma Homo sapiens 142-151 10485926-7 1999 The release of IFN-gamma from activated T cells is also inhibited after block of IK channels by clotrimazole. Clotrimazole 96-108 interferon gamma Homo sapiens 15-24 10520184-7 1999 The production of IFN-gamma and IL-4 following CD3-CD28 stimulation of RA PB MNC correlated significantly in a ratio 1 : 1 with production following ionomycin-PMA stimulation. Ionomycin 149-158 interferon gamma Homo sapiens 18-27 10520184-7 1999 The production of IFN-gamma and IL-4 following CD3-CD28 stimulation of RA PB MNC correlated significantly in a ratio 1 : 1 with production following ionomycin-PMA stimulation. Tetradecanoylphorbol Acetate 159-162 interferon gamma Homo sapiens 18-27 10477626-6 1999 Similarly, there was no difference in IL-12 production between stimulated BAL or PB T cells; however, addition of rIL-12 significantly increased production of IFN-gamma by BAL T cells, but not by PB T cells. ril-12 114-120 interferon gamma Homo sapiens 159-168 10527564-5 1999 We detected significantly greater levels of the Th2 cytokines IL-6 and IL-10 in normal pregnancy compared to unexplained RSA and significantly higher levels of the Th1 cytokine IFN-gamma in RSA compared to normal pregnancy. rabbit sperm membrane autoantigen 190-193 interferon gamma Homo sapiens 177-186 10479403-3 1999 5-Bromo-2"-deoxyuridine-based flow cytometric analysis of the growth-arrested cells, 24 h subsequent to the removal of IFN-gamma, showed absence of DNA synthesis, confirming the irreversible nature of the growth inhibition. Bromodeoxyuridine 0-23 interferon gamma Homo sapiens 119-128 10480630-8 1999 When purified T cells from HIV-infected individuals were stimulated by immobilized anti-CD3 in the presence of thalidomide, a costimulatory effect of the drug was observed, resulting in increased production of IL-2 and IFN-gamma, and increased T cell-proliferative responses. Thalidomide 111-122 interferon gamma Homo sapiens 219-228 10559642-6 1999 Following challenge with the combination of inflammatory cytokines IL-1beta, TNF-alpha, and IFN-gamma, such cultures exhibit a time-dependent increase in inducible NO synthetase induction and corresponding NO production, an effect which was inhibited by L-NMMA. omega-N-Methylarginine 254-260 interferon gamma Homo sapiens 92-101 10528802-7 1999 From these results we conclude that: (1) inhibition of IFN-gamma synthesis, as well as IFN-gamma-induced expression of costimulatory molecules and NK-cell effector functions may lead to suppression of specific and non-specific defense mechanisms, respectively, which are necessary for elimination of PA bacteria; (2) enhancement of IFN-gamma synthesis induced by P-ExA in a combination with IL-1alpha may cause harmful, Th1 cells dependent, inflammatory reactions of the host (septic shock, tissue damage) during infection with Pseudomonas aeruginosa. Protactinium 300-302 interferon gamma Homo sapiens 87-96 10469049-3 1999 The aim of this study was to investigate the effect of IFN-gamma and PGE2 on lipopolysaccharide (LPS)-stimulated LPMC IL-12 production. lpmc 113-117 interferon gamma Homo sapiens 55-64 10469049-9 1999 Treatment of LPMC with IFN-gamma facilitated LPS-stimulated IL-12, whereas it completely abrogated IL-10 production. lpmc 13-17 interferon gamma Homo sapiens 23-32 10496308-6 1999 Heparin induced IL-12 and interferon-gamma production but did not promote the release of other cytokines. Heparin 0-7 interferon gamma Homo sapiens 26-42 10469049-10 1999 IL-12 release by LPMC stimulated with IFN-gamma and LPS was significantly inhibited by exogenous IL-10. lpmc 17-21 interferon gamma Homo sapiens 38-47 10469049-11 1999 The addition of PGE2 to IFN-gamma-treated LPMC cultures inhibited in a dose-dependent manner LPS-induced IL-12 secretion. Dinoprostone 16-20 interferon gamma Homo sapiens 24-33 10469049-11 1999 The addition of PGE2 to IFN-gamma-treated LPMC cultures inhibited in a dose-dependent manner LPS-induced IL-12 secretion. lpmc 42-46 interferon gamma Homo sapiens 24-33 10469049-17 1999 IFN-gamma and PGE2 modulate differently the LPMC responsiveness to LPS in terms of IL-12 synthesis. lpmc 44-48 interferon gamma Homo sapiens 0-9 10480302-7 1999 PTX treatment also induced a decrease in IFN-gamma levels in the sera of 6 HAM patients, but this was not correlated with clinical improvement. Pentoxifylline 0-3 interferon gamma Homo sapiens 41-50 10528802-7 1999 From these results we conclude that: (1) inhibition of IFN-gamma synthesis, as well as IFN-gamma-induced expression of costimulatory molecules and NK-cell effector functions may lead to suppression of specific and non-specific defense mechanisms, respectively, which are necessary for elimination of PA bacteria; (2) enhancement of IFN-gamma synthesis induced by P-ExA in a combination with IL-1alpha may cause harmful, Th1 cells dependent, inflammatory reactions of the host (septic shock, tissue damage) during infection with Pseudomonas aeruginosa. Protactinium 300-302 interferon gamma Homo sapiens 87-96 10496181-4 1999 After IFNbeta therapy, the production of interleukin-4 was decreased in MBP-stimulated TCL while the secretion of interferon-gamma was increased in unstimulated TCL. Triclosan 161-164 interferon gamma Homo sapiens 114-130 10428812-11 1999 The interferon-gamma-activated tyrosine phosphorylation of Jak2 and Stat3 was independent of the extracellular matrix. Tyrosine 31-39 interferon gamma Homo sapiens 4-20 10453004-3 1999 In contrast, simultaneous stimulation with IFN-gamma and LPS, or pretreatment with LPS for >4 h, suppressed Stat1 tyrosine 701 phosphorylation, dimerization, and transcriptional activity in response to IFN-gamma. Tyrosine 117-125 interferon gamma Homo sapiens 43-52 10453004-3 1999 In contrast, simultaneous stimulation with IFN-gamma and LPS, or pretreatment with LPS for >4 h, suppressed Stat1 tyrosine 701 phosphorylation, dimerization, and transcriptional activity in response to IFN-gamma. Tyrosine 117-125 interferon gamma Homo sapiens 205-214 10453017-5 1999 Second, the addition of excess exogenous rhIL-10 partially inhibited the beryllium-stimulated production of IL-2, IFN-gamma, and TNF-alpha; however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. Beryllium 73-82 interferon gamma Homo sapiens 114-123 11783190-8 1999 GL-B significantly increased TNF alpha and IFN gamma release and their mRNA expression in the cultured medium. gl-b 0-4 interferon gamma Homo sapiens 43-52 10430055-4 1999 After amantadine treatment, the in vitro IL-2 secretion defect was corrected to normal levels in half of the patients, and the increase in IL-2 production was correlated with an increase in IFN-gamma secretion. Amantadine 6-16 interferon gamma Homo sapiens 190-199 10505747-1 1999 An intronic dinucleotide polymorphism in the IFN-gamma gene (IFNG) was used as a marker for testing association with multiple sclerosis (MS). Dinucleoside Phosphates 12-24 interferon gamma Homo sapiens 45-54 10505747-1 1999 An intronic dinucleotide polymorphism in the IFN-gamma gene (IFNG) was used as a marker for testing association with multiple sclerosis (MS). Dinucleoside Phosphates 12-24 interferon gamma Homo sapiens 61-65 10479754-0 1999 Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506. triptolide 0-10 interferon gamma Homo sapiens 68-84 10479754-7 1999 The results show that, overall, triptolide is more effective at inhibiting T cell proliferation and IFNgamma production than FK506 and the two compounds inhibit IL-2 production in an equivalent manner. triptolide 32-42 interferon gamma Homo sapiens 100-108 10482358-3 1999 Both regulatory regions in these IL-4-primed naive CD4+ T cells, which produce a large amount of IFN-gamma upon stimulation with PMA and ionomycin, were completely methylated in contrast to the same hypomethylated regions in Th1 cells. Ionomycin 137-146 interferon gamma Homo sapiens 97-106 10470745-0 1999 Acidic conditions exacerbate interferon-gamma-induced intestinal epithelial hyperpermeability: role of peroxynitrous acid. Peroxynitrous Acid 103-121 interferon gamma Homo sapiens 29-45 10470745-14 1999 CONCLUSION: Mild acidosis augments IFN-gamma-induced intestinal epithelial hyperpermeability and ATP depletion, possibly by fostering the formation of peroxynitrous acid and/or hydroxyl radical. Adenosine Triphosphate 97-100 interferon gamma Homo sapiens 35-44 10470745-12 1999 However, when the cells were incubated for 72 hrs with the same concentration of IFN-gamma under mildly acidic conditions (i.e., pHo 7.0 or 6.6), ATP levels were significantly decreased. Adenosine Triphosphate 146-149 interferon gamma Homo sapiens 81-90 10470745-13 1999 At pHo 7.0, IFN-gamma-induced increases in permeability were ameliorated by addition of the following agents: 2-phenyl-4,4,5,5- tetramethylimidazoline-1-oxyl-3-oxide (a NO* scavenger), N(G)-monomethyl-L-arginine (a iNOS inhibitor), dimethyl sulfoxide (a hydroxyl radical scavenger), and ascorbate (a peroxynitrous acid scavenger). 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide 110-165 interferon gamma Homo sapiens 12-21 10470745-13 1999 At pHo 7.0, IFN-gamma-induced increases in permeability were ameliorated by addition of the following agents: 2-phenyl-4,4,5,5- tetramethylimidazoline-1-oxyl-3-oxide (a NO* scavenger), N(G)-monomethyl-L-arginine (a iNOS inhibitor), dimethyl sulfoxide (a hydroxyl radical scavenger), and ascorbate (a peroxynitrous acid scavenger). omega-N-Methylarginine 185-211 interferon gamma Homo sapiens 12-21 10470745-13 1999 At pHo 7.0, IFN-gamma-induced increases in permeability were ameliorated by addition of the following agents: 2-phenyl-4,4,5,5- tetramethylimidazoline-1-oxyl-3-oxide (a NO* scavenger), N(G)-monomethyl-L-arginine (a iNOS inhibitor), dimethyl sulfoxide (a hydroxyl radical scavenger), and ascorbate (a peroxynitrous acid scavenger). Dimethyl Sulfoxide 232-250 interferon gamma Homo sapiens 12-21 10470745-13 1999 At pHo 7.0, IFN-gamma-induced increases in permeability were ameliorated by addition of the following agents: 2-phenyl-4,4,5,5- tetramethylimidazoline-1-oxyl-3-oxide (a NO* scavenger), N(G)-monomethyl-L-arginine (a iNOS inhibitor), dimethyl sulfoxide (a hydroxyl radical scavenger), and ascorbate (a peroxynitrous acid scavenger). Hydroxyl Radical 254-270 interferon gamma Homo sapiens 12-21 10470745-13 1999 At pHo 7.0, IFN-gamma-induced increases in permeability were ameliorated by addition of the following agents: 2-phenyl-4,4,5,5- tetramethylimidazoline-1-oxyl-3-oxide (a NO* scavenger), N(G)-monomethyl-L-arginine (a iNOS inhibitor), dimethyl sulfoxide (a hydroxyl radical scavenger), and ascorbate (a peroxynitrous acid scavenger). Ascorbic Acid 287-296 interferon gamma Homo sapiens 12-21 10470745-13 1999 At pHo 7.0, IFN-gamma-induced increases in permeability were ameliorated by addition of the following agents: 2-phenyl-4,4,5,5- tetramethylimidazoline-1-oxyl-3-oxide (a NO* scavenger), N(G)-monomethyl-L-arginine (a iNOS inhibitor), dimethyl sulfoxide (a hydroxyl radical scavenger), and ascorbate (a peroxynitrous acid scavenger). Peroxynitrous Acid 300-318 interferon gamma Homo sapiens 12-21 10470745-14 1999 CONCLUSION: Mild acidosis augments IFN-gamma-induced intestinal epithelial hyperpermeability and ATP depletion, possibly by fostering the formation of peroxynitrous acid and/or hydroxyl radical. Peroxynitrous Acid 151-169 interferon gamma Homo sapiens 35-44 10470745-14 1999 CONCLUSION: Mild acidosis augments IFN-gamma-induced intestinal epithelial hyperpermeability and ATP depletion, possibly by fostering the formation of peroxynitrous acid and/or hydroxyl radical. Hydroxyl Radical 177-193 interferon gamma Homo sapiens 35-44 10469304-6 1999 Accordingly, the amount of interferon-gamma was elevated in culture supernatants from 8-methoxypsoralen-phototreated peripheral blood mononuclear cells, whereas interleukin-4 was significantly reduced. Methoxsalen 86-103 interferon gamma Homo sapiens 27-43 10428508-5 1999 Furthermore, inhibition of CrkL or CrkII protein expression by antisense oligonucleotides, reverses the inhibitory effects of IFNalpha or IFNgamma on the proliferation of normal bone marrow progenitor cells (colony forming units-granulocytic/monocytic [CFU-GM] and burst-forming units-erythroid [BFU-E]). Oligonucleotides 73-89 interferon gamma Homo sapiens 138-146 10403730-5 1999 RESULTS: Relative to controls, significant changes (p<0.05) occurred in cells incubated with IFN-gamma for two days: TER was decreased to 20 (6.2)%, FITC-dextran flux was increased by 109 (19)-fold, cAMP and Ca dependent I(sc) were decreased to 51 (6.4)% and 24 (2.2)%, respectively, and CFTR levels were decreased to 47 (11)%. fluorescein isothiocyanate dextran 152-164 interferon gamma Homo sapiens 96-105 10403730-5 1999 RESULTS: Relative to controls, significant changes (p<0.05) occurred in cells incubated with IFN-gamma for two days: TER was decreased to 20 (6.2)%, FITC-dextran flux was increased by 109 (19)-fold, cAMP and Ca dependent I(sc) were decreased to 51 (6.4)% and 24 (2.2)%, respectively, and CFTR levels were decreased to 47 (11)%. Cyclic AMP 202-206 interferon gamma Homo sapiens 96-105 10403730-9 1999 Relative to controls, significant changes occurred after one day of culture with IFN-gamma plus TNF-alpha: TER was decreased to 27 (3.5)%, FITC-dextran flux was increased by 185 (45)-fold, and cAMP and Ca dependent I(sc) were decreased to 66 (12)% and 35 (6.8)%, respectively. fluorescein isothiocyanate dextran 139-151 interferon gamma Homo sapiens 81-90 10403730-9 1999 Relative to controls, significant changes occurred after one day of culture with IFN-gamma plus TNF-alpha: TER was decreased to 27 (3.5)%, FITC-dextran flux was increased by 185 (45)-fold, and cAMP and Ca dependent I(sc) were decreased to 66 (12)% and 35 (6.8)%, respectively. Cyclic AMP 193-197 interferon gamma Homo sapiens 81-90 10469304-7 1999 This enhanced production of interferon-gamma, however, was found only until 3 d after 8-methoxypsoralen phototreatment and was declined by 5 d after treatment. Methoxsalen 86-103 interferon gamma Homo sapiens 28-44 10391892-5 1999 In support of this hypothesis, both exposure of cells to S-nitrosoglutathione and stimulation of endogenous nitric oxide production by lipopolysaccharide/interferon-gamma treatment result in inhibition of proteasome activity as measured in vitro by the degradation of the proteasome-specific substrate succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin-7-amide. S-Nitrosoglutathione 57-77 interferon gamma Homo sapiens 154-170 10446891-4 1999 Lung endothelial cells stimulated with interferon-gamma plus lipopolysaccharide (IFNgamma + LPS) generated high levels of nitric oxide (*NO), while dermal endothelial cells stimulated with IFNgamma + LPS generated significantly lower levels of *NO. Nitric Oxide 122-134 interferon gamma Homo sapiens 39-55 10446891-4 1999 Lung endothelial cells stimulated with interferon-gamma plus lipopolysaccharide (IFNgamma + LPS) generated high levels of nitric oxide (*NO), while dermal endothelial cells stimulated with IFNgamma + LPS generated significantly lower levels of *NO. Nitric Oxide 122-134 interferon gamma Homo sapiens 81-89 11360598-13 1999 CONCLUSION: TNF-alpha and IFN-gamma could induce apoptosis of human trophoblasts during early pregnancy, partly through the mechanism of ROS. Reactive Oxygen Species 137-140 interferon gamma Homo sapiens 26-35 10391892-5 1999 In support of this hypothesis, both exposure of cells to S-nitrosoglutathione and stimulation of endogenous nitric oxide production by lipopolysaccharide/interferon-gamma treatment result in inhibition of proteasome activity as measured in vitro by the degradation of the proteasome-specific substrate succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin-7-amide. Nitric Oxide 108-120 interferon gamma Homo sapiens 154-170 10391892-5 1999 In support of this hypothesis, both exposure of cells to S-nitrosoglutathione and stimulation of endogenous nitric oxide production by lipopolysaccharide/interferon-gamma treatment result in inhibition of proteasome activity as measured in vitro by the degradation of the proteasome-specific substrate succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin-7-amide. succinyl-leu-leu-val-tyr-4-methylcoumarin-7-amide 302-351 interferon gamma Homo sapiens 154-170 10383394-0 1999 CD44, a cell surface chondroitin sulfate proteoglycan, mediates binding of interferon-gamma and some of its biological effects on human vascular smooth muscle cells. Chondroitin Sulfates 21-40 interferon gamma Homo sapiens 75-91 10383394-4 1999 We found that treatment of HASMC with chondroitinase ABC, an enzyme that degrades chondroitin sulfate GAG, reduced IFN-gamma binding by more than 50%. hasmc 27-32 interferon gamma Homo sapiens 115-124 10383394-4 1999 We found that treatment of HASMC with chondroitinase ABC, an enzyme that degrades chondroitin sulfate GAG, reduced IFN-gamma binding by more than 50%. Chondroitin Sulfates 82-101 interferon gamma Homo sapiens 115-124 10383394-4 1999 We found that treatment of HASMC with chondroitinase ABC, an enzyme that degrades chondroitin sulfate GAG, reduced IFN-gamma binding by more than 50%. Glycosaminoglycans 102-105 interferon gamma Homo sapiens 115-124 10383394-9 1999 The interaction of IFN-gamma with chondroitin sulfate GAG was confirmed by affinity chromatography of isolated cell-associated 35S-, 3H-labeled PG on a column with immobilized IFN-gamma. Chondroitin Sulfates 34-53 interferon gamma Homo sapiens 19-28 10383394-9 1999 The interaction of IFN-gamma with chondroitin sulfate GAG was confirmed by affinity chromatography of isolated cell-associated 35S-, 3H-labeled PG on a column with immobilized IFN-gamma. Chondroitin Sulfates 34-53 interferon gamma Homo sapiens 176-185 10383394-9 1999 The interaction of IFN-gamma with chondroitin sulfate GAG was confirmed by affinity chromatography of isolated cell-associated 35S-, 3H-labeled PG on a column with immobilized IFN-gamma. Glycosaminoglycans 54-57 interferon gamma Homo sapiens 19-28 10383394-9 1999 The interaction of IFN-gamma with chondroitin sulfate GAG was confirmed by affinity chromatography of isolated cell-associated 35S-, 3H-labeled PG on a column with immobilized IFN-gamma. Glycosaminoglycans 54-57 interferon gamma Homo sapiens 176-185 10383394-9 1999 The interaction of IFN-gamma with chondroitin sulfate GAG was confirmed by affinity chromatography of isolated cell-associated 35S-, 3H-labeled PG on a column with immobilized IFN-gamma. Sulfur-35 127-130 interferon gamma Homo sapiens 19-28 10383394-9 1999 The interaction of IFN-gamma with chondroitin sulfate GAG was confirmed by affinity chromatography of isolated cell-associated 35S-, 3H-labeled PG on a column with immobilized IFN-gamma. Tritium 133-135 interferon gamma Homo sapiens 19-28 10383394-10 1999 The cell-associated PG that binds to IFN-gamma was a chondroitin sulfate PG (CSPG). Chondroitin Sulfates 53-72 interferon gamma Homo sapiens 37-46 10383394-12 1999 High molecular weight complexes between IFN-gamma and chondroitin 6-sulfate were observed in gel exclusion chromatography. Chondroitin Sulfates 54-75 interferon gamma Homo sapiens 40-49 10383394-13 1999 Additions of chondroitin 6-sulfate to cultured HASMC antagonized the antiproliferative effect and expression of major histocompatibility complex II antigens induced by IFN-gamma. Chondroitin Sulfates 13-34 interferon gamma Homo sapiens 168-177 10383394-13 1999 Additions of chondroitin 6-sulfate to cultured HASMC antagonized the antiproliferative effect and expression of major histocompatibility complex II antigens induced by IFN-gamma. hasmc 47-52 interferon gamma Homo sapiens 168-177 10383394-14 1999 These results indicate that IFN-gamma binds with low affinity to the chondroitin sulfate GAG moiety of the cell surface CSPG receptor CD44. chondroitin sulfate glycosaminoglycan 69-92 interferon gamma Homo sapiens 28-37 10419056-5 1999 The biological activity of hIL-12 in the conditioned media was also demonstrated in vitro through its ability to induce interferon-gamma production from peripheral blood mononuclear cells (PBMCs), to stimulate PBMC proliferation, and to enhance natural killer activity from normal human PBMCs to lyse natural killer-sensitive K562 target cells. hil-12 27-33 interferon gamma Homo sapiens 120-136 10388538-0 1999 Interferon-gamma inhibits CD44-hyaluronan interactions in normal human B lymphocytes. Hyaluronic Acid 31-41 interferon gamma Homo sapiens 0-16 10388538-4 1999 Stimulation of B cells with the phorbol ester PMA, however, induced strong HA recognition, which was inhibited by IFN-gamma and to some extent by IL-4. Phorbol Esters 32-45 interferon gamma Homo sapiens 114-123 10388538-8 1999 These results suggest that the inhibition of PMA-induced HA adhesion by IFN-gamma and IL-4 may influence B cell migration through their ability to downregulate CD44-HA interactions. Tetradecanoylphorbol Acetate 45-48 interferon gamma Homo sapiens 72-81 10437816-2 1999 METHODS: Human bronchial epithelial cells, obtained from surgically resected bronchi, were cultured and stimulated with recombinant IFN-gamma in the presence of sodium nedocromil. Nedocromil 161-178 interferon gamma Homo sapiens 132-141 10437816-7 1999 RESULTS: The enhanced HLA-DR and ICAM-1 expression, induced by IFN-gamma, was effectively downregulated, in a dose-dependent manner, by sodium nedocromil. Nedocromil 136-153 interferon gamma Homo sapiens 63-72 10383096-8 1999 The inhibitory effect of Se on the adhesion molecule expression was studied in cultured endothelial cells after interferon-gamma stimulation. Selenium 25-27 interferon gamma Homo sapiens 112-128 10419647-7 1999 With Genistein, an inhibitor of tyrosine kinase, the IFN-gamma-induced IP-10 mRNA expression was also found to be diminished. Genistein 5-14 interferon gamma Homo sapiens 53-62 10427997-0 1999 Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-gamma production in cells from allergic individuals and inhibit IgE synthesis in vitro. Oligodeoxyribonucleotides 0-21 interferon gamma Homo sapiens 68-77 10419646-2 1999 We show here that the reduction of LPL activity in J774.2 macrophages observed in the presence of interleukin (IL-1) and IL-11 was sensitive to herbimycin A, with the effect of LPS, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) on LPL activity being sensitive to both herbimycin A and wortmannin. herbimycin 144-156 interferon gamma Homo sapiens 182-198 10419646-2 1999 We show here that the reduction of LPL activity in J774.2 macrophages observed in the presence of interleukin (IL-1) and IL-11 was sensitive to herbimycin A, with the effect of LPS, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) on LPL activity being sensitive to both herbimycin A and wortmannin. herbimycin 144-156 interferon gamma Homo sapiens 200-209 10450792-8 1999 RESULTS: The base line and tumor necrosis factor (TNF)-alpha or interferon (IFN)-gamma induced ROS values were similar in the four groups, and the individual measures did not show a correlation with MS associated mtDNA haplotypes. Reactive Oxygen Species 95-98 interferon gamma Homo sapiens 64-86 10384106-5 1999 Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 64-69 interferon gamma Homo sapiens 217-226 10384106-5 1999 Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene. Celecoxib 73-82 interferon gamma Homo sapiens 217-226 10454343-2 1999 In TNF-alpha-treated cells, IFN-gamma-induced phosphorylation of Jak2 kinase is increased, Jak2 kinase activity is enhanced, and genetic studies indicate that TNF-alpha requires Jak2 kinase activity to enhance Stat1alpha tyrosine phosphorylation. Tyrosine 221-229 interferon gamma Homo sapiens 28-37 10454343-4 1999 IFN-gamma receptor chain 1 (IFNGR-1) tyrosine phosphorylation is markedly enhanced in cells treated with TNF-alpha/IFN-gamma without alteration in receptor levels. Tyrosine 37-45 interferon gamma Homo sapiens 0-9 10383594-9 1999 In contrast with the observations with ISO, PGE2 still dose-dependently inhibited IFN-gamma mRNA, both before, 3 h and 24 h after allergen provocation (n = 7). Dinoprostone 44-48 interferon gamma Homo sapiens 82-91 10410997-4 1999 Almost pure (>99%) cord blood-derived MC (CBMC) were shown to express class II Ags (HLA-DR and HLA-DQ) and CD80, which were up-regulated by IFN-gamma treatment and, to a lesser extent, by interleukin-4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF). cbmc 45-49 interferon gamma Homo sapiens 143-152 10410997-7 1999 Furthermore, an additional pretreatment of CBMC by IFN-gamma or GM-CSF or IL-4 had no effect on their presenting efficiency. cbmc 43-47 interferon gamma Homo sapiens 51-60 10513354-0 1999 Effect of fluticasone propionate on interleukin-12 and interferon-gamma production in patients affected by allergic bronchial asthma. Fluticasone 10-32 interferon gamma Homo sapiens 55-71 10513354-8 1999 Patients treated with fluticasone propionate also displayed increased levels of IFN-gamma in either blood culture supernatants (59.12 +/- 16.88 vs. 18.87 +/- 7.53 IU/ml; p < 0.05) or in sera (5.60 +/- 2.87 vs. < 1 IU/ml; p < 0.05). Fluticasone 22-44 interferon gamma Homo sapiens 80-89 11360653-6 1999 The synergistic effect of PMA combined with IFN-gamma in the induction of B7-1 expression can be anatagonised by H7 [1-(5-isoquinolinesulfonyl)-2-methyl-Piperazine dihydrochloride]. H-7 dihydrochloride 117-179 interferon gamma Homo sapiens 44-53 10567951-5 1999 IFN-gamma-elicited ICAM-1 expression was synergistically increased by PGF2 alpha, whereas TNF alpha-induced ICAM-1 expression was slightly inhibited by PGF2 alpha. Dinoprost 70-74 interferon gamma Homo sapiens 0-9 10567951-9 1999 From these data, we suggest that PGF2 alpha upregulates ICAM-1 expression in HGF and synergistically enhances IFN-gamma-induced ICAM-1 expression through FP receptor by calcium calmodulin-dependent and PKC-dependent pathways. Dinoprost 33-37 interferon gamma Homo sapiens 110-119 10383134-4 1999 Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. dihydroeponemycin 0-17 interferon gamma Homo sapiens 112-121 10414782-4 1999 In contrast to the MTT-measurements the combined agents are more effective in inhibiting interleukin-4 (IL-4)- and interferon-gamma (IFN-gamma)-production. monooxyethylene trimethylolpropane tristearate 19-22 interferon gamma Homo sapiens 115-131 10414782-4 1999 In contrast to the MTT-measurements the combined agents are more effective in inhibiting interleukin-4 (IL-4)- and interferon-gamma (IFN-gamma)-production. monooxyethylene trimethylolpropane tristearate 19-22 interferon gamma Homo sapiens 133-142 10366428-3 1999 Previously, we reported that IFN-gamma augments Fas-dependent apoptosis of SV40-transformed human keratinocytes (SVHK cells). ammonium ferrous sulfate 48-51 interferon gamma Homo sapiens 29-38 10397812-2 1999 Detailed analysis of the N-glycosylation of recombinant human IFN-gamma by matrix-assisted laser-desorption mass spectrometry showed that the protein secreted by Chinese hamster ovary and baculovirus-infected insect Sf9 cells was associated with complex sialylated or truncated tri-mannosyl core glycans, respectively. Nitrogen 25-26 interferon gamma Homo sapiens 62-71 10397812-2 1999 Detailed analysis of the N-glycosylation of recombinant human IFN-gamma by matrix-assisted laser-desorption mass spectrometry showed that the protein secreted by Chinese hamster ovary and baculovirus-infected insect Sf9 cells was associated with complex sialylated or truncated tri-mannosyl core glycans, respectively. Polysaccharides 296-303 interferon gamma Homo sapiens 62-71 10358155-8 1999 In polarized Th1 and Th2 cell lines, SB 203580 strongly inhibited IL-4 production by Th2 cells (IC50 = 10-80 nM), but only partially inhibited IFN-gamma and IL-2 production by Th1 cells (<50% inhibition at 1 microM). SB 203580 37-46 interferon gamma Homo sapiens 143-152 10339499-5 1999 Our results show that TPA + IFN-gamma treatment led to an inhibition of v-Myc- and c-Myc-dependent transcription, and a specific reduction of v-Myc:Max complexes and associated DNA-binding activity, whereas the steady state level of the v-Myc protein was only marginally affected. Tetradecanoylphorbol Acetate 22-25 interferon gamma Homo sapiens 28-37 10358077-2 1999 A combination of the pro-inflammatory cytokines interleukin (IL)-1alpha, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha induces nitric oxide synthase mRNA expression and nitric oxide (NO) generation in the human colon carcinoma cell line HT-29. Nitric Oxide 143-155 interferon gamma Homo sapiens 73-95 10357750-2 1999 Particularly, T helper cell type 1 (Th1) activity, ie, interferon (IFN) gamma-producing Th1 activity and, hence, delayed-type hypersensitivity (DTH) would be enhanced by vitamin E supplementation. Vitamin E 170-179 interferon gamma Homo sapiens 55-77 10357750-6 1999 However, IFN-gamma production decreased whereas IL-4 production increased in the groups receiving vitamin E. Vitamin E 98-107 interferon gamma Homo sapiens 9-18 10339499-8 1999 Phosphatase treatment of Myc:Max complexes lead to their dissociation, thus mimicking the effect of TPA + IFN-gamma. Tetradecanoylphorbol Acetate 100-103 interferon gamma Homo sapiens 106-115 10361231-7 1999 Similarly, IL-4 and IL-10 inhibit neopterin production and tryptophan degradation in PBMC by down-regulating Th1-type cytokine production and possibly also via direct deactivation of IFN-gamma effects towards monocytes/macrophages. Neopterin 34-43 interferon gamma Homo sapiens 183-192 10336593-4 1999 OBJECTIVE: To assess interferon (IFN)-gamma, IL-4 and IL-5 mRNA expressions and their control by prostaglandin E2 (PGE2), which activates adenylyl cyclases, of peripheral T lymphocytes from patients with moderately severe asthma and healthy controls. Dinoprostone 97-113 interferon gamma Homo sapiens 21-43 10336593-4 1999 OBJECTIVE: To assess interferon (IFN)-gamma, IL-4 and IL-5 mRNA expressions and their control by prostaglandin E2 (PGE2), which activates adenylyl cyclases, of peripheral T lymphocytes from patients with moderately severe asthma and healthy controls. Dinoprostone 115-119 interferon gamma Homo sapiens 21-43 10336593-10 1999 Accumulation of mRNA for IFN-gamma, IL-4 and IL-5 mRNA were significantly diminished by 10-5 m PGE2 in both asthmatics and controls. Dinoprostone 95-99 interferon gamma Homo sapiens 25-34 10336593-11 1999 In contrast, 10-6 m PGE2 significantly down-regulated IFN-gamma and IL-4 mRNAs (P < 0.05 for both IFN-gamma and IL-4, n = 4) in the control group, whereas this was not observed for IL-4 mRNA in the asthma group (n = 7). Dinoprostone 20-24 interferon gamma Homo sapiens 54-63 10336593-11 1999 In contrast, 10-6 m PGE2 significantly down-regulated IFN-gamma and IL-4 mRNAs (P < 0.05 for both IFN-gamma and IL-4, n = 4) in the control group, whereas this was not observed for IL-4 mRNA in the asthma group (n = 7). Dinoprostone 20-24 interferon gamma Homo sapiens 101-110 10389633-4 1999 In vitro studies revealed that human monocytes/macrophages produce neopterin when stimulated by interferon-gamma. Neopterin 67-76 interferon gamma Homo sapiens 96-112 10502453-7 1999 Retinoic acid with TNFalpha and IFN-gamma had a marked inhibitory effect (P<0.05) which was similarly reversed by increasing concentrations of IGFBP-3 antibody. Tretinoin 0-13 interferon gamma Homo sapiens 32-41 10502453-8 1999 The present data support the hypothesis that the combination of TNFalpha and IFN-gamma with retinoic acid exert their anti-proliferative effect on HSG cells by reducing the mitogenic effect of IGF-I due to a shift in IGF-I from the free to the IGFBP-3-bound form. Tretinoin 92-105 interferon gamma Homo sapiens 77-86 10437653-5 1999 In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol. Nitrites 244-251 interferon gamma Homo sapiens 65-74 10437653-5 1999 In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol. Nitrates 252-259 interferon gamma Homo sapiens 65-74 10437653-5 1999 In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol. vsmc 302-306 interferon gamma Homo sapiens 65-74 10437653-5 1999 In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol. Nitrogen Dioxide 357-360 interferon gamma Homo sapiens 65-74 10437653-5 1999 In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol. Nitrogen Dioxide 453-456 interferon gamma Homo sapiens 65-74 10437653-5 1999 In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol. punky blue 362-365 interferon gamma Homo sapiens 65-74 10437653-6 1999 This inhibitory effect of G-CSF was still present after a 48 h incubation period (G-CSF + IFN-gamma/LPS: 319.56 +/- 6.26 nmol NO2-/NO3-/mg cell protein; IFN-gamma/LPS: 489.20 +/- 27.15 nmol NO2-/NO3-/mg cell protein (P < 0.05), n = 8, respectively). Nitrogen Dioxide 126-130 interferon gamma Homo sapiens 90-99 10437653-6 1999 This inhibitory effect of G-CSF was still present after a 48 h incubation period (G-CSF + IFN-gamma/LPS: 319.56 +/- 6.26 nmol NO2-/NO3-/mg cell protein; IFN-gamma/LPS: 489.20 +/- 27.15 nmol NO2-/NO3-/mg cell protein (P < 0.05), n = 8, respectively). punky blue 131-134 interferon gamma Homo sapiens 90-99 10437653-6 1999 This inhibitory effect of G-CSF was still present after a 48 h incubation period (G-CSF + IFN-gamma/LPS: 319.56 +/- 6.26 nmol NO2-/NO3-/mg cell protein; IFN-gamma/LPS: 489.20 +/- 27.15 nmol NO2-/NO3-/mg cell protein (P < 0.05), n = 8, respectively). Nitrogen Dioxide 126-129 interferon gamma Homo sapiens 90-99 10447735-6 1999 Exogenous IFN-gamma did not activate OvAg-specific proliferative responses in patients, but anti-IFN-gamma antibodies abolished cellular reactivity to OvAg. ovag 151-155 interferon gamma Homo sapiens 97-106 10447735-7 1999 Antibody to IL-10 increased (P<0.05) OvAg-specific production of IL-5, IL-12 and IFN-gamma, and inversely, anti-IFN-gamma enhanced IL-10 (in patients only) and IL-5 and IL-13 in both patients and controls. ovag 40-44 interferon gamma Homo sapiens 84-93 10447735-8 1999 Neutralization of IL-12 activated OvAg-specific production of IL-10, IL-2 and IFN-gamma. ovag 34-38 interferon gamma Homo sapiens 78-87 10361231-2 1999 Neopterin formation and tryptophan degradation were induced similarly by IFN-gamma in all three cell types investigated, but the effects of interleukins were different between THP-1, primary macrophages and PBMC. Neopterin 0-9 interferon gamma Homo sapiens 73-82 10361231-3 1999 In PBMC, but not in THP-1 cells and primary macrophages, IL-12 was found to be additive to the effects of IFN-gamma to superinduce neopterin formation and tryptophan degradation. Neopterin 131-140 interferon gamma Homo sapiens 106-115 10361231-3 1999 In PBMC, but not in THP-1 cells and primary macrophages, IL-12 was found to be additive to the effects of IFN-gamma to superinduce neopterin formation and tryptophan degradation. Tryptophan 155-165 interferon gamma Homo sapiens 106-115 10361231-6 1999 The results show that IL-12 up-regulates neopterin formation and tryptophan degradation by inducing additional IFN-gamma production by Th1 cells, while a direct effect of IL-12 on monocytes/macrophages appears to be absent. Neopterin 41-50 interferon gamma Homo sapiens 111-120 10408967-5 1999 In this study, we demonstrate that while vesnarinone enhances basal TNF alpha levels, it inhibits TNF alpha production in peripheral blood mononuclear cells from multiple sclerosis (MS) patients and healthy donors stimulated with lipopolysaccharide (LPS) or primed with IFNgamma and stimulated with suboptimal doses of LPS. vesnarinone 41-52 interferon gamma Homo sapiens 270-278 10433370-5 1999 We further demonstrated that aspirin, but not dexamethasone, suppressed IFN-gamma-induced STAT activation. Aspirin 29-36 interferon gamma Homo sapiens 72-81 10423959-11 1999 Clinical trial of inhalation therapy with IFN-gamma showed some improvement for drug-resistant TB. Terbium 95-97 interferon gamma Homo sapiens 42-51 10442856-7 1999 Conditioned medium from ethanol-treated cells increased the IFN-gamma-induced iNOS mRNA of naive cells by threefold. Ethanol 24-31 interferon gamma Homo sapiens 60-69 10349844-8 1999 Moreover, pretreatment with interferon-gamma partially suppressed the induction of heme oxygenase-1 mRNA expression caused by either sodium nitroprusside, cadmium, or hemin. Nitroprusside 133-153 interferon gamma Homo sapiens 28-44 10349844-8 1999 Moreover, pretreatment with interferon-gamma partially suppressed the induction of heme oxygenase-1 mRNA expression caused by either sodium nitroprusside, cadmium, or hemin. Cadmium 155-162 interferon gamma Homo sapiens 28-44 10349844-8 1999 Moreover, pretreatment with interferon-gamma partially suppressed the induction of heme oxygenase-1 mRNA expression caused by either sodium nitroprusside, cadmium, or hemin. Hemin 167-172 interferon gamma Homo sapiens 28-44 10442856-8 1999 Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells. Ethanol 55-62 interferon gamma Homo sapiens 251-260 10442856-8 1999 Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells. Ethanol 55-62 interferon gamma Homo sapiens 72-81 10442856-8 1999 Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells. Ethanol 55-62 interferon gamma Homo sapiens 251-260 10442856-9 1999 Because IFN-gamma and IL-1beta are produced by intestinal immune cells, these findings may have implications for differential in vivo regulation of epithelial iNOS genes by ethanol, depending on the inflammatory and immune status of the host. Ethanol 173-180 interferon gamma Homo sapiens 8-17 10233883-12 1999 These results indicate that IFNgamma acts on ECFC not only to upregulate Fas, but also to selectively upregulate caspases-1, -3, and -8, which are activated and produce apoptosis, whereas the concentrations of FasL and FADD are not demonstrably changed. ammonium ferrous sulfate 73-76 interferon gamma Homo sapiens 28-36 10233023-1 1999 In L6 myotubes, glucose uptake stimulated by interferon (IFN)-gamma or lipopolysaccharides (LPS) and a combination of LPS, IFN-gamma, and tumor necrosis factor (TNF)-alpha was inhibited by the antioxidant pyrrolidinedithiocarbamate and potentiated in reduced glutathione (GSH)-deficient cells. Glucose 16-23 interferon gamma Homo sapiens 45-67 10233023-1 1999 In L6 myotubes, glucose uptake stimulated by interferon (IFN)-gamma or lipopolysaccharides (LPS) and a combination of LPS, IFN-gamma, and tumor necrosis factor (TNF)-alpha was inhibited by the antioxidant pyrrolidinedithiocarbamate and potentiated in reduced glutathione (GSH)-deficient cells. pyrrolidine dithiocarbamic acid 205-231 interferon gamma Homo sapiens 45-67 10233023-1 1999 In L6 myotubes, glucose uptake stimulated by interferon (IFN)-gamma or lipopolysaccharides (LPS) and a combination of LPS, IFN-gamma, and tumor necrosis factor (TNF)-alpha was inhibited by the antioxidant pyrrolidinedithiocarbamate and potentiated in reduced glutathione (GSH)-deficient cells. Glutathione 259-270 interferon gamma Homo sapiens 45-67 10233023-1 1999 In L6 myotubes, glucose uptake stimulated by interferon (IFN)-gamma or lipopolysaccharides (LPS) and a combination of LPS, IFN-gamma, and tumor necrosis factor (TNF)-alpha was inhibited by the antioxidant pyrrolidinedithiocarbamate and potentiated in reduced glutathione (GSH)-deficient cells. Glutathione 272-275 interferon gamma Homo sapiens 45-67 10233023-2 1999 Also, the stimulatory effect of LPS and IFN-gamma individually, and of a combination of LPS, IFN-gamma, and TNF-alpha, on glucose uptake was associated with an increased level of intracellular oxidants (dichlorofluorescein assay) and loss of intracellular GSH. Glucose 122-129 interferon gamma Homo sapiens 40-49 10233023-2 1999 Also, the stimulatory effect of LPS and IFN-gamma individually, and of a combination of LPS, IFN-gamma, and TNF-alpha, on glucose uptake was associated with an increased level of intracellular oxidants (dichlorofluorescein assay) and loss of intracellular GSH. Glucose 122-129 interferon gamma Homo sapiens 93-102 10233023-2 1999 Also, the stimulatory effect of LPS and IFN-gamma individually, and of a combination of LPS, IFN-gamma, and TNF-alpha, on glucose uptake was associated with an increased level of intracellular oxidants (dichlorofluorescein assay) and loss of intracellular GSH. 2',7'-dichlorofluorescein 203-222 interferon gamma Homo sapiens 40-49 10233023-2 1999 Also, the stimulatory effect of LPS and IFN-gamma individually, and of a combination of LPS, IFN-gamma, and TNF-alpha, on glucose uptake was associated with an increased level of intracellular oxidants (dichlorofluorescein assay) and loss of intracellular GSH. 2',7'-dichlorofluorescein 203-222 interferon gamma Homo sapiens 93-102 10233023-2 1999 Also, the stimulatory effect of LPS and IFN-gamma individually, and of a combination of LPS, IFN-gamma, and TNF-alpha, on glucose uptake was associated with an increased level of intracellular oxidants (dichlorofluorescein assay) and loss of intracellular GSH. Glutathione 256-259 interferon gamma Homo sapiens 40-49 10470106-1 1999 In vitro, large amounts of neopterin are produced by human monocytes/macrophages upon stimulation with interferon-gamma. Neopterin 27-36 interferon gamma Homo sapiens 103-119 10352298-1 1999 Treatment of cultured peritoneal macrophages with IFN-gamma resulted in tyrosine phosphorylation of IkappaBalpha and IkappaBbeta, NF-kappaB activation, and expression of inducible NO synthase (iNOS). Tyrosine 72-80 interferon gamma Homo sapiens 50-59 10384911-7 1999 VIP, at 10(-5) mol/l and serotonin at 10(-4) mol/l stimulated the secretion of interferon gamma. Serotonin 25-34 interferon gamma Homo sapiens 79-95 10228104-12 1999 Lower IFN-gamma production at the time of bronchiolitis is an indicator of lower pulmonary function and increased responsiveness to histamine 4.9 mo after bronchiolitis and is related to the development of asthma after bronchiolitis in infants. Histamine 132-141 interferon gamma Homo sapiens 6-15 10233023-2 1999 Also, the stimulatory effect of LPS and IFN-gamma individually, and of a combination of LPS, IFN-gamma, and TNF-alpha, on glucose uptake was associated with an increased level of intracellular oxidants (dichlorofluorescein assay) and loss of intracellular GSH. Glutathione 256-259 interferon gamma Homo sapiens 93-102 10329948-7 1999 T4-directed STAT1alpha Ser-727 phosphorylation is MAPK mediated and results in potentiated STAT1alpha activation and enhanced IFN-gamma activity. Serine 23-26 interferon gamma Homo sapiens 126-135 10442856-8 1999 Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells. Ethanol 25-32 interferon gamma Homo sapiens 72-81 10442856-8 1999 Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells. Ethanol 25-32 interferon gamma Homo sapiens 251-260 10442856-8 1999 Two different effects of ethanol are now reported: (a) ethanol inhibits IFN-gamma + IL-1beta-induced iNOS mRNA of the same DLD-1 cells and (b) ethanol induces cellular paracrine signals by releasing IL-1beta into the medium, which in combination with IFN-gamma increases iNOS mRNA levels of the recipient naive DLD-1 cells. Ethanol 55-62 interferon gamma Homo sapiens 72-81 10328871-0 1999 Binding of interferon gamma by glycosaminoglycans: a strategy for localization and/or inhibition of its activity. Glycosaminoglycans 31-49 interferon gamma Homo sapiens 11-27 10337026-4 1999 LPC induced interferon-gamma (IFN-gamma) secretion in peripheral blood mononuclear leucocytes from healthy blood donors. Lysophosphatidylcholines 0-3 interferon gamma Homo sapiens 12-28 10337026-4 1999 LPC induced interferon-gamma (IFN-gamma) secretion in peripheral blood mononuclear leucocytes from healthy blood donors. Lysophosphatidylcholines 0-3 interferon gamma Homo sapiens 30-39 10337026-8 1999 We recently demonstrated that PAF and oxLDL induce IFN-gamma secretion by a common mechanism. Platelet Activating Factor 30-33 interferon gamma Homo sapiens 51-60 10227809-0 1999 Acetylcholine receptor alpha subunit mRNA expression in human thymus: augmented expression in myasthenia gravis and upregulation by interferon-gamma. Acetylcholine 0-13 interferon gamma Homo sapiens 132-148 10328871-3 1999 A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs. Heparitin Sulfate 28-43 interferon gamma Homo sapiens 172-181 10369458-1 1999 Ceramide, generated by the hydrolysis of sphingomyelin, mediates the actions of several cytokines such as tumour necrosis factor-alpha (TNF-alpha) interferon-gamma and interleukin-1beta (IL-1beta), including their inhibitory effect on tumour proliferation. Ceramides 0-8 interferon gamma Homo sapiens 147-163 10328871-3 1999 A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs. Heparitin Sulfate 28-43 interferon gamma Homo sapiens 234-243 10369458-1 1999 Ceramide, generated by the hydrolysis of sphingomyelin, mediates the actions of several cytokines such as tumour necrosis factor-alpha (TNF-alpha) interferon-gamma and interleukin-1beta (IL-1beta), including their inhibitory effect on tumour proliferation. Sphingomyelins 41-54 interferon gamma Homo sapiens 147-163 10328871-3 1999 A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs. Chondroitin Sulfates 45-64 interferon gamma Homo sapiens 172-181 10328871-3 1999 A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs. Hyaluronic Acid 69-84 interferon gamma Homo sapiens 172-181 10328871-3 1999 A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs. Hyaluronic Acid 69-84 interferon gamma Homo sapiens 234-243 10328871-3 1999 A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs. Polysaccharides 110-124 interferon gamma Homo sapiens 172-181 10328871-3 1999 A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs. Polysaccharides 110-124 interferon gamma Homo sapiens 234-243 10328871-3 1999 A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs. Dextran Sulfate 126-141 interferon gamma Homo sapiens 172-181 10328871-3 1999 A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs. Dextran Sulfate 126-141 interferon gamma Homo sapiens 234-243 10328871-4 1999 These interactions were inhibited by synthetic peptides mimicking the sequences of the basic amino acid cluster located at the C-terminal end of mouse and human IFN-gamma, or by poly-L-lysine, suggesting that ionic interactions between the positively-charged C-terminus and negatively charged groups in GAGs were involved. Amino Acids, Basic 87-103 interferon gamma Homo sapiens 161-170 10755257-11 1999 An increase in IFN-gamma levels was also seen when coeliac biopsies were cultured with FFIII and L-NMMA (P< 0.05). ffiii 87-92 interferon gamma Homo sapiens 15-24 10755257-11 1999 An increase in IFN-gamma levels was also seen when coeliac biopsies were cultured with FFIII and L-NMMA (P< 0.05). omega-N-Methylarginine 97-103 interferon gamma Homo sapiens 15-24 10329044-2 1999 Previously, we have reported that interferon-gamma (IFN-gamma) sensitizes human ovarian carcinoma cell lines to Fas-mediated apoptosis. ammonium ferrous sulfate 112-115 interferon gamma Homo sapiens 34-50 10359121-5 1999 They specifically recognize different types of glycolipids, such as gangliosides, sulfatide and galactosylceramide and release IFN-gamma and TNF-alpha. Glycolipids 47-58 interferon gamma Homo sapiens 127-136 10359121-5 1999 They specifically recognize different types of glycolipids, such as gangliosides, sulfatide and galactosylceramide and release IFN-gamma and TNF-alpha. Sulfoglycosphingolipids 82-91 interferon gamma Homo sapiens 127-136 10359121-5 1999 They specifically recognize different types of glycolipids, such as gangliosides, sulfatide and galactosylceramide and release IFN-gamma and TNF-alpha. Galactosylceramides 96-114 interferon gamma Homo sapiens 127-136 10329044-10 1999 Blocking iNOS activity by NG-monomethyl-l-arginine (l-NMA) significantly reduced the sensitization, Fas mRNA, and protein expression observed with IFN-gamma pretreatment of the tumor cells. omega-N-Methylarginine 26-50 interferon gamma Homo sapiens 147-156 10205202-1 1999 BACKGROUND: Impairment of intestinal barrier function occurs under a variety of inflammatory conditions and is mediated at least in part by interferon gamma (IFN-gamma) induced nitric oxide (NO) production. Nitric Oxide 177-189 interferon gamma Homo sapiens 140-167 12783649-2 1999 The release of reactive nitrogen intermediates was triggered by incubation with various proinflammatory cytokines namely IFN gamma,TNF-alpha and IL-1R. reactive nitrogen 15-32 interferon gamma Homo sapiens 121-130 10329044-2 1999 Previously, we have reported that interferon-gamma (IFN-gamma) sensitizes human ovarian carcinoma cell lines to Fas-mediated apoptosis. ammonium ferrous sulfate 112-115 interferon gamma Homo sapiens 52-61 10329044-10 1999 Blocking iNOS activity by NG-monomethyl-l-arginine (l-NMA) significantly reduced the sensitization, Fas mRNA, and protein expression observed with IFN-gamma pretreatment of the tumor cells. l-nma 52-57 interferon gamma Homo sapiens 147-156 10329044-11 1999 These findings demonstrate that sensitization of human ovarian carcinoma cell lines to Fas-mediated apoptosis by IFN-gamma can be due, in part, to the induction of iNOS and the subsequent upregulation of Fas gene expression by reactive nitrogen intermediates. ammonium ferrous sulfate 87-90 interferon gamma Homo sapiens 113-122 10329044-7 1999 There was accumulation of nitrite in the culture medium of IFN-gamma-treated cells, suggesting the generation of NOx. Nitrites 26-33 interferon gamma Homo sapiens 59-68 10329044-11 1999 These findings demonstrate that sensitization of human ovarian carcinoma cell lines to Fas-mediated apoptosis by IFN-gamma can be due, in part, to the induction of iNOS and the subsequent upregulation of Fas gene expression by reactive nitrogen intermediates. reactive nitrogen 227-244 interferon gamma Homo sapiens 113-122 10329044-7 1999 There was accumulation of nitrite in the culture medium of IFN-gamma-treated cells, suggesting the generation of NOx. nicotine 1-N-oxide 113-116 interferon gamma Homo sapiens 59-68 10329044-8 1999 Like IFN-gamma, the use of exogenous sources of NO (S-nitroso-N-acetylpenicillamine (SNAP)) mimicked the sensitization of both cell lines to anti-Fas cytotoxic antibody (CH11) by IFN-gamma. S-Nitroso-N-Acetylpenicillamine 52-83 interferon gamma Homo sapiens 179-188 10203603-0 1999 Interferon gamma increases the antitumor activity of mitomycin C against human colon cancer cells in vitro and in vivo. Mitomycin 53-64 interferon gamma Homo sapiens 0-16 10320641-5 1999 An increase in H mRNA was observed as early as 2 h after addition of IFN-gamma; the response peaked at 24 h. The half-life of H mRNA in the presence of IFN-gamma was 3.8 +/- 0.8 h. The increase in H mRNA by IFN-gamma was partly dependent on protein synthesis, as cycloheximide (CHX) reduced the response by 40% and the level of H mRNA decreased in a dose-dependent manner with increasing concentrations of CHX. Cycloheximide 263-276 interferon gamma Homo sapiens 69-78 10320641-5 1999 An increase in H mRNA was observed as early as 2 h after addition of IFN-gamma; the response peaked at 24 h. The half-life of H mRNA in the presence of IFN-gamma was 3.8 +/- 0.8 h. The increase in H mRNA by IFN-gamma was partly dependent on protein synthesis, as cycloheximide (CHX) reduced the response by 40% and the level of H mRNA decreased in a dose-dependent manner with increasing concentrations of CHX. Cycloheximide 263-276 interferon gamma Homo sapiens 152-161 10320641-5 1999 An increase in H mRNA was observed as early as 2 h after addition of IFN-gamma; the response peaked at 24 h. The half-life of H mRNA in the presence of IFN-gamma was 3.8 +/- 0.8 h. The increase in H mRNA by IFN-gamma was partly dependent on protein synthesis, as cycloheximide (CHX) reduced the response by 40% and the level of H mRNA decreased in a dose-dependent manner with increasing concentrations of CHX. Cycloheximide 263-276 interferon gamma Homo sapiens 152-161 10320641-5 1999 An increase in H mRNA was observed as early as 2 h after addition of IFN-gamma; the response peaked at 24 h. The half-life of H mRNA in the presence of IFN-gamma was 3.8 +/- 0.8 h. The increase in H mRNA by IFN-gamma was partly dependent on protein synthesis, as cycloheximide (CHX) reduced the response by 40% and the level of H mRNA decreased in a dose-dependent manner with increasing concentrations of CHX. Cycloheximide 278-281 interferon gamma Homo sapiens 69-78 10320641-5 1999 An increase in H mRNA was observed as early as 2 h after addition of IFN-gamma; the response peaked at 24 h. The half-life of H mRNA in the presence of IFN-gamma was 3.8 +/- 0.8 h. The increase in H mRNA by IFN-gamma was partly dependent on protein synthesis, as cycloheximide (CHX) reduced the response by 40% and the level of H mRNA decreased in a dose-dependent manner with increasing concentrations of CHX. Cycloheximide 278-281 interferon gamma Homo sapiens 152-161 10320641-5 1999 An increase in H mRNA was observed as early as 2 h after addition of IFN-gamma; the response peaked at 24 h. The half-life of H mRNA in the presence of IFN-gamma was 3.8 +/- 0.8 h. The increase in H mRNA by IFN-gamma was partly dependent on protein synthesis, as cycloheximide (CHX) reduced the response by 40% and the level of H mRNA decreased in a dose-dependent manner with increasing concentrations of CHX. Cycloheximide 278-281 interferon gamma Homo sapiens 152-161 10353535-8 1999 Both calcium ionophore, A23187, and the protein kinase C (PKC) activator phorbol-myristate-acetate (PMA) had a synergistic effect on IFN-gamma-induced EC apoptosis (p < .05). Calcium 5-12 interferon gamma Homo sapiens 133-142 10353535-8 1999 Both calcium ionophore, A23187, and the protein kinase C (PKC) activator phorbol-myristate-acetate (PMA) had a synergistic effect on IFN-gamma-induced EC apoptosis (p < .05). Calcimycin 24-30 interferon gamma Homo sapiens 133-142 10353535-8 1999 Both calcium ionophore, A23187, and the protein kinase C (PKC) activator phorbol-myristate-acetate (PMA) had a synergistic effect on IFN-gamma-induced EC apoptosis (p < .05). Tetradecanoylphorbol Acetate 73-98 interferon gamma Homo sapiens 133-142 10353535-8 1999 Both calcium ionophore, A23187, and the protein kinase C (PKC) activator phorbol-myristate-acetate (PMA) had a synergistic effect on IFN-gamma-induced EC apoptosis (p < .05). Tetradecanoylphorbol Acetate 100-103 interferon gamma Homo sapiens 133-142 10353535-10 1999 Three specific tyrosine protein kinase (TPK) inhibitors, herbimycin A, tyrphostin, and genistein, significantly inhibited IFN-gamma-induced EC apoptosis in a dose-dependent fashion (p < .05). herbimycin 57-69 interferon gamma Homo sapiens 122-131 10353535-10 1999 Three specific tyrosine protein kinase (TPK) inhibitors, herbimycin A, tyrphostin, and genistein, significantly inhibited IFN-gamma-induced EC apoptosis in a dose-dependent fashion (p < .05). Tyrphostins 71-81 interferon gamma Homo sapiens 122-131 10353535-10 1999 Three specific tyrosine protein kinase (TPK) inhibitors, herbimycin A, tyrphostin, and genistein, significantly inhibited IFN-gamma-induced EC apoptosis in a dose-dependent fashion (p < .05). Genistein 87-96 interferon gamma Homo sapiens 122-131 10353535-12 1999 These findings suggest that the signal transduction pathway required for induction of EC apoptosis by IFN-gamma is TPK dependent and is independent of calcium and PKC. Calcium 151-158 interferon gamma Homo sapiens 102-111 10201972-0 1999 Cutting edge: phorbol ester induction of IFN-gamma receptors leads to enhanced DR alpha gene expression. Phorbol Esters 14-27 interferon gamma Homo sapiens 41-50 10201972-1 1999 We observed that IFN-gamma-inducible expression of the DR alpha gene was enhanced when THP-1 cells are differentiated into macrophage-like cells by phorbol ester treatment. Phorbol Esters 148-161 interferon gamma Homo sapiens 17-26 10201972-2 1999 Here, we observed that class II MHC trans-activator and STAT1 alpha mRNA, mediators of the signaling cascade from the IFN-gamma receptor to the DR alpha induction, were markedly increased by IFN-gamma stimulation in phorbol ester-activated THP-1 cells; however, both mRNAs were not increased by phorbol ester treatment alone. Phorbol Esters 216-229 interferon gamma Homo sapiens 118-127 10201972-2 1999 Here, we observed that class II MHC trans-activator and STAT1 alpha mRNA, mediators of the signaling cascade from the IFN-gamma receptor to the DR alpha induction, were markedly increased by IFN-gamma stimulation in phorbol ester-activated THP-1 cells; however, both mRNAs were not increased by phorbol ester treatment alone. Phorbol Esters 216-229 interferon gamma Homo sapiens 191-200 10201972-2 1999 Here, we observed that class II MHC trans-activator and STAT1 alpha mRNA, mediators of the signaling cascade from the IFN-gamma receptor to the DR alpha induction, were markedly increased by IFN-gamma stimulation in phorbol ester-activated THP-1 cells; however, both mRNAs were not increased by phorbol ester treatment alone. Phorbol Esters 295-308 interferon gamma Homo sapiens 118-127 10201972-2 1999 Here, we observed that class II MHC trans-activator and STAT1 alpha mRNA, mediators of the signaling cascade from the IFN-gamma receptor to the DR alpha induction, were markedly increased by IFN-gamma stimulation in phorbol ester-activated THP-1 cells; however, both mRNAs were not increased by phorbol ester treatment alone. Phorbol Esters 295-308 interferon gamma Homo sapiens 191-200 10201972-3 1999 Then, we demonstrated that the mRNA and proteins of the IFN-gamma receptor alpha- and beta-chains were amplified by phorbol ester treatment in THP-1 cells. Phorbol Esters 116-129 interferon gamma Homo sapiens 56-65 10201972-4 1999 Consequently, these results indicate that the enhancement of DR alpha gene expression by IFN-gamma treatment in phorbol ester-activated THP-1 cells is due to the phorbol ester-induced up-regulation of IFN-gamma receptor alpha- and beta-chains. Phorbol Esters 112-125 interferon gamma Homo sapiens 89-98 10201972-4 1999 Consequently, these results indicate that the enhancement of DR alpha gene expression by IFN-gamma treatment in phorbol ester-activated THP-1 cells is due to the phorbol ester-induced up-regulation of IFN-gamma receptor alpha- and beta-chains. Phorbol Esters 112-125 interferon gamma Homo sapiens 201-210 10201972-4 1999 Consequently, these results indicate that the enhancement of DR alpha gene expression by IFN-gamma treatment in phorbol ester-activated THP-1 cells is due to the phorbol ester-induced up-regulation of IFN-gamma receptor alpha- and beta-chains. Phorbol Esters 162-175 interferon gamma Homo sapiens 89-98 10201972-4 1999 Consequently, these results indicate that the enhancement of DR alpha gene expression by IFN-gamma treatment in phorbol ester-activated THP-1 cells is due to the phorbol ester-induced up-regulation of IFN-gamma receptor alpha- and beta-chains. Phorbol Esters 162-175 interferon gamma Homo sapiens 201-210 10187764-0 1999 Rapid inactivation of NOS-I by lipopolysaccharide plus interferon-gamma-induced tyrosine phosphorylation. Tyrosine 80-88 interferon gamma Homo sapiens 55-71 10203603-1 1999 A combined antitumor activity of mitomycin C (MMC) and interferon gamma-1a (IFN-gamma) was evaluated to be synergistic by the 3-(4, 5-dimethylthiazol-2yl)-2,5-diphenyl-2H tetrazolium bromide assay and human tumor xenografts/severe combined immunodeficient (SCID) mouse system using colon cancer cell lines. 3-(4, 5-dimethylthiazol-2yl)-2,5-diphenyl-2h tetrazolium bromide 126-190 interferon gamma Homo sapiens 55-71 10203603-1 1999 A combined antitumor activity of mitomycin C (MMC) and interferon gamma-1a (IFN-gamma) was evaluated to be synergistic by the 3-(4, 5-dimethylthiazol-2yl)-2,5-diphenyl-2H tetrazolium bromide assay and human tumor xenografts/severe combined immunodeficient (SCID) mouse system using colon cancer cell lines. 3-(4, 5-dimethylthiazol-2yl)-2,5-diphenyl-2h tetrazolium bromide 126-190 interferon gamma Homo sapiens 76-85 10203603-3 1999 Intracellular uptake of MMC in WiDr cells in vitro was significantly increased by IFN-gamma, suggesting the mode of synergism of these agents. Mitomycin 24-27 interferon gamma Homo sapiens 82-91 10199820-0 1999 Regulation of intracellular polyamine biosynthesis and transport by NO and cytokines TNF-alpha and IFN-gamma. Polyamines 28-37 interferon gamma Homo sapiens 99-108 10198263-1 1999 Previously CD11a or leukocyte function-associated antigen alpha-1 was found to be induced at the surface protein level in thioglycolate-elicited peritoneal macrophages by bacterial lipopolysaccharide and interferon-gamma. Thioglycolates 122-135 interferon gamma Homo sapiens 204-220 10199820-4 1999 This study was undertaken to determine the effects NO and the NO synthase (NOS)-inducing cytokines, tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), exert on polyamine regulation. Polyamines 183-192 interferon gamma Homo sapiens 144-160 10187764-4 1999 Furthermore, LPS plus IFNgamma increased the tyrosine phosphorylation of NOS-I, with a concomitant inhibition of its enzyme activity. Tyrosine 45-53 interferon gamma Homo sapiens 22-30 10199820-4 1999 This study was undertaken to determine the effects NO and the NO synthase (NOS)-inducing cytokines, tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), exert on polyamine regulation. Polyamines 183-192 interferon gamma Homo sapiens 162-171 10199820-7 1999 TNF-alpha and IFN-gamma induction of NO generation resulted in suppressed ODC activity, an effect prevented by the inducible NOS inhibitor L-N6-(1-iminoethyl)lysine (L-NIL). N(6)-(1-iminoethyl)lysine 139-164 interferon gamma Homo sapiens 14-23 10187764-8 1999 Because exogenous NO has been found to suppress NOS-II expression, the decrease of NO production that we have obtained from the inactivation of NOS-I by LPS/IFNgamma-induced tyrosine phosphorylation provides the best conditions for NOS-II expression in human astrocytoma T67 cells. Tyrosine 174-182 interferon gamma Homo sapiens 157-165 10199820-7 1999 TNF-alpha and IFN-gamma induction of NO generation resulted in suppressed ODC activity, an effect prevented by the inducible NOS inhibitor L-N6-(1-iminoethyl)lysine (L-NIL). N(6)-(1-iminoethyl)lysine 166-171 interferon gamma Homo sapiens 14-23 10199820-10 1999 Administration of NO donors, or TNF-alpha and IFN-gamma, suppressed [3H]putrescine uptake, thereby preventing transport-mediated reestablishment of intracellular polyamine levels. Tritium 69-71 interferon gamma Homo sapiens 46-55 10374702-6 1999 The number of IFN-gamma- as well as IL-4-secreting cells in pregnancy weeks 17-20 in the RSA group was significantly higher compared with before pregnancy, pregnancy weeks 7-10, and after pregnancy. rabbit sperm membrane autoantigen 89-92 interferon gamma Homo sapiens 14-23 10199820-10 1999 Administration of NO donors, or TNF-alpha and IFN-gamma, suppressed [3H]putrescine uptake, thereby preventing transport-mediated reestablishment of intracellular polyamine levels. Putrescine 72-82 interferon gamma Homo sapiens 46-55 10374702-7 1999 In samples from non-pregnant women, the number of IFN-gamma- and IL-4-secreting cells was significantly higher in the RSA group compared with controls. rabbit sperm membrane autoantigen 118-121 interferon gamma Homo sapiens 50-59 10199820-10 1999 Administration of NO donors, or TNF-alpha and IFN-gamma, suppressed [3H]putrescine uptake, thereby preventing transport-mediated reestablishment of intracellular polyamine levels. Polyamines 162-171 interferon gamma Homo sapiens 46-55 10233311-10 1999 In addition, stimulation of a human mast cell line HMC-1 with phorbol myristate acetate (PMA) (100 nmol/L) for periods of 2-24 h induced expression of IFN-gamma mRNA, which peaked at 24 h. When HMC-1 cells were stimulated with PMA (100 nmol/L) for periods of 0-3 days, the cells released IFN-gamma protein, peaking on day 1. Tetradecanoylphorbol Acetate 62-87 interferon gamma Homo sapiens 151-160 10233311-10 1999 In addition, stimulation of a human mast cell line HMC-1 with phorbol myristate acetate (PMA) (100 nmol/L) for periods of 2-24 h induced expression of IFN-gamma mRNA, which peaked at 24 h. When HMC-1 cells were stimulated with PMA (100 nmol/L) for periods of 0-3 days, the cells released IFN-gamma protein, peaking on day 1. Tetradecanoylphorbol Acetate 62-87 interferon gamma Homo sapiens 288-297 10233311-10 1999 In addition, stimulation of a human mast cell line HMC-1 with phorbol myristate acetate (PMA) (100 nmol/L) for periods of 2-24 h induced expression of IFN-gamma mRNA, which peaked at 24 h. When HMC-1 cells were stimulated with PMA (100 nmol/L) for periods of 0-3 days, the cells released IFN-gamma protein, peaking on day 1. Tetradecanoylphorbol Acetate 89-92 interferon gamma Homo sapiens 151-160 10233311-10 1999 In addition, stimulation of a human mast cell line HMC-1 with phorbol myristate acetate (PMA) (100 nmol/L) for periods of 2-24 h induced expression of IFN-gamma mRNA, which peaked at 24 h. When HMC-1 cells were stimulated with PMA (100 nmol/L) for periods of 0-3 days, the cells released IFN-gamma protein, peaking on day 1. Tetradecanoylphorbol Acetate 89-92 interferon gamma Homo sapiens 288-297 10233311-10 1999 In addition, stimulation of a human mast cell line HMC-1 with phorbol myristate acetate (PMA) (100 nmol/L) for periods of 2-24 h induced expression of IFN-gamma mRNA, which peaked at 24 h. When HMC-1 cells were stimulated with PMA (100 nmol/L) for periods of 0-3 days, the cells released IFN-gamma protein, peaking on day 1. Tetradecanoylphorbol Acetate 227-230 interferon gamma Homo sapiens 151-160 10319996-6 1999 We provide evidence indicating that RA-induced IRF-1 gene expression is independent of the STAT-1 activation pathway, despite the presence of the IFN-gamma activated sequence element in the gene promoter, but involves nuclear factor-kappaB activation. Tretinoin 36-38 interferon gamma Homo sapiens 146-155 10328864-5 1999 IL-17 and interferon gamma(IFN-gamma) mRNA were both inhibited in the presence of PGE2 or the cAMP analogue (dibutyryl-cAMP), while the anti-inflammatory cytokine IL-10 was highly increased. Dinoprostone 82-86 interferon gamma Homo sapiens 10-36 10328864-5 1999 IL-17 and interferon gamma(IFN-gamma) mRNA were both inhibited in the presence of PGE2 or the cAMP analogue (dibutyryl-cAMP), while the anti-inflammatory cytokine IL-10 was highly increased. Cyclic AMP 94-98 interferon gamma Homo sapiens 10-36 10328864-5 1999 IL-17 and interferon gamma(IFN-gamma) mRNA were both inhibited in the presence of PGE2 or the cAMP analogue (dibutyryl-cAMP), while the anti-inflammatory cytokine IL-10 was highly increased. dibutyryl 109-118 interferon gamma Homo sapiens 10-36 10344276-3 1999 Our goal is to identify and map IFN-gamma-regulated HeLa cell proteins to the two-dimensional polyacrylamide gel electrophoresis with the immobilized pH gradient (IPG) two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) system. polyacrylamide 94-108 interferon gamma Homo sapiens 32-41 10328864-5 1999 IL-17 and interferon gamma(IFN-gamma) mRNA were both inhibited in the presence of PGE2 or the cAMP analogue (dibutyryl-cAMP), while the anti-inflammatory cytokine IL-10 was highly increased. Cyclic AMP 119-123 interferon gamma Homo sapiens 10-36 10344276-3 1999 Our goal is to identify and map IFN-gamma-regulated HeLa cell proteins to the two-dimensional polyacrylamide gel electrophoresis with the immobilized pH gradient (IPG) two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) system. polyacrylamide 184-198 interferon gamma Homo sapiens 32-41 10328864-10 1999 However, we suggest that PGE2 may be more efficient in blocking both IL-17 and IFN-gamma expression in already primed memory T cells, rather than in suppressing naive T cells that could represent a significant source of IL-10. Dinoprostone 25-29 interferon gamma Homo sapiens 79-88 10323213-6 1999 Priming in the presence of rIL-12 strongly enhanced the production of IFN-gamma in both CD4SP and CD8SP cells. ril-12 27-33 interferon gamma Homo sapiens 70-79 10085001-2 1999 In human epithelial cells and macrophages, this inhibition is the result of depletion of the essential amino acid tryptophan via the IFN-gamma-induced enzyme indoleamine 2, 3-dioxygenase. essential amino acid tryptophan 93-124 interferon gamma Homo sapiens 133-142 10085001-7 1999 We propose that intracellular tryptophan pool sizes can account for differences in IFN-gamma-mediated chlamydial persistence and growth inhibition in polarized and nonpolarized cells. Tryptophan 30-40 interferon gamma Homo sapiens 83-92 10102295-7 1999 Activation of IFN-gamma-responsive genes was mediated by tyrosine phosphorylation of the signal transducer and activator of transcription (STAT)-1 factor. Tyrosine 57-65 interferon gamma Homo sapiens 14-23 10102295-8 1999 CONCLUSIONS: This study characterized the IFN-gamma signaling pathway in HRPE cells and identified IRF-1, ICSBP, and tyrosine-phosphorylated STAT1 as mediators of IFN-gamma action in these cells. Tyrosine 117-125 interferon gamma Homo sapiens 163-172 10194481-7 1999 In experiments on isolated ASM tissue segments (a) exogenous administration of IL-2 and IFN-gamma to atopic asthmatic serum-sensitized ASM ablated both their enhanced constrictor responsiveness to acetylcholine (ACh) and their attenuated relaxation responsiveness to beta-adrenoceptor stimulation with isoproterenol, and (b) administration of IL-5 and GM-CSF to naive ASM induced significant increases in their contractility to ACh and impaired their relaxant responsiveness to isoproterenol. Acetylcholine 197-210 interferon gamma Homo sapiens 88-97 10344474-8 1999 Hydrocortisone (10(-4) M) inhibited IL-5 and IFNgamma release. Hydrocortisone 0-14 interferon gamma Homo sapiens 45-53 10082137-12 1999 Gel mobility shift analysis showed that two distinct and specific DNA-protein complexes were formed when fibroblast nuclear extracts were incubated with oligonucleotides spanning the IFN-gamma response region. Oligonucleotides 153-169 interferon gamma Homo sapiens 183-192 10201928-8 1999 IFN-gamma stimulation results in a loss of IL-4-induced Stat6 tyrosine phosphorylation, nuclear translocation, and DNA binding. Tyrosine 62-70 interferon gamma Homo sapiens 0-9 10204571-4 1999 In normal human macrophage cultures, IFN-gamma was the most potent stimulus for QUIN formation. Quinolinic Acid 80-84 interferon gamma Homo sapiens 37-46 10219845-9 1999 IFN-gamma levels secreted by activated LPMC were lower in patients with UC than in controls [1571 pg/ml (-108 to 3251) vs 7953 pg/ml (3851-12,055), respectively, P = 0.03]. lpmc 39-43 interferon gamma Homo sapiens 0-9 10194481-7 1999 In experiments on isolated ASM tissue segments (a) exogenous administration of IL-2 and IFN-gamma to atopic asthmatic serum-sensitized ASM ablated both their enhanced constrictor responsiveness to acetylcholine (ACh) and their attenuated relaxation responsiveness to beta-adrenoceptor stimulation with isoproterenol, and (b) administration of IL-5 and GM-CSF to naive ASM induced significant increases in their contractility to ACh and impaired their relaxant responsiveness to isoproterenol. Acetylcholine 212-215 interferon gamma Homo sapiens 88-97 10194481-7 1999 In experiments on isolated ASM tissue segments (a) exogenous administration of IL-2 and IFN-gamma to atopic asthmatic serum-sensitized ASM ablated both their enhanced constrictor responsiveness to acetylcholine (ACh) and their attenuated relaxation responsiveness to beta-adrenoceptor stimulation with isoproterenol, and (b) administration of IL-5 and GM-CSF to naive ASM induced significant increases in their contractility to ACh and impaired their relaxant responsiveness to isoproterenol. Isoproterenol 302-315 interferon gamma Homo sapiens 88-97 10194481-7 1999 In experiments on isolated ASM tissue segments (a) exogenous administration of IL-2 and IFN-gamma to atopic asthmatic serum-sensitized ASM ablated both their enhanced constrictor responsiveness to acetylcholine (ACh) and their attenuated relaxation responsiveness to beta-adrenoceptor stimulation with isoproterenol, and (b) administration of IL-5 and GM-CSF to naive ASM induced significant increases in their contractility to ACh and impaired their relaxant responsiveness to isoproterenol. Acetylcholine 428-431 interferon gamma Homo sapiens 88-97 10194481-7 1999 In experiments on isolated ASM tissue segments (a) exogenous administration of IL-2 and IFN-gamma to atopic asthmatic serum-sensitized ASM ablated both their enhanced constrictor responsiveness to acetylcholine (ACh) and their attenuated relaxation responsiveness to beta-adrenoceptor stimulation with isoproterenol, and (b) administration of IL-5 and GM-CSF to naive ASM induced significant increases in their contractility to ACh and impaired their relaxant responsiveness to isoproterenol. Isoproterenol 478-491 interferon gamma Homo sapiens 88-97 10088138-3 1999 This study was carried out to examine the effects of clomipramine, sertraline, and trazodone on the stimulated production of IFN gamma, a pro-inflammatory cytokine, and IL-10, a negative immunoregulatory cytokine. Clomipramine 53-65 interferon gamma Homo sapiens 125-134 10088138-3 1999 This study was carried out to examine the effects of clomipramine, sertraline, and trazodone on the stimulated production of IFN gamma, a pro-inflammatory cytokine, and IL-10, a negative immunoregulatory cytokine. Sertraline 67-77 interferon gamma Homo sapiens 125-134 10088138-3 1999 This study was carried out to examine the effects of clomipramine, sertraline, and trazodone on the stimulated production of IFN gamma, a pro-inflammatory cytokine, and IL-10, a negative immunoregulatory cytokine. Trazodone 83-92 interferon gamma Homo sapiens 125-134 10079079-1 1999 We previously observed that IFN gamma-inducible expression of the human MHC class II, HLA-DR alpha, gene was enhanced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) only in human monocytic leukemia THP-1 cells, but not in HeLa cells. Tetradecanoylphorbol Acetate 136-172 interferon gamma Homo sapiens 28-37 10334392-0 1999 Retinoids synergize with interleukin-2 to augment IFN-gamma and interleukin-12 production by human peripheral blood mononuclear cells. Retinoids 0-9 interferon gamma Homo sapiens 50-59 10334392-5 1999 IL-2 or retinoids alone could induce low but significant levels of IFN-gamma. Retinoids 8-17 interferon gamma Homo sapiens 67-76 10334392-6 1999 However, when IL-2 was cultured with each retinoid, a synergistic augmentation of IFN-gamma levels (4-fold to 90-fold) was observed except in the case of etretinate. Retinoids 42-50 interferon gamma Homo sapiens 82-91 10334392-9 1999 The IFN-y-inducing effect of ATRA and 13-cis-retinoic acid could be abrogated by addition of anti-IL-12 antibodies, suggesting that IL-12 plays a role in the synergistic upregulation of IFN-gamma. Tretinoin 29-33 interferon gamma Homo sapiens 186-195 10334392-9 1999 The IFN-y-inducing effect of ATRA and 13-cis-retinoic acid could be abrogated by addition of anti-IL-12 antibodies, suggesting that IL-12 plays a role in the synergistic upregulation of IFN-gamma. Isotretinoin 38-58 interferon gamma Homo sapiens 186-195 10432720-2 1999 This is an underlying mechanism for substantially enhanced production of nitric oxide generated by IFN-gamma. Nitric Oxide 73-85 interferon gamma Homo sapiens 99-108 10367558-6 1999 CONCLUSIONS: The results suggest that lithium has significant immunoregulatory effects by increasing the production of both proinflammatory cytokines (IFNgamma, TNFalpha and IL-8) and negative immunoregulatory cytokines or proteins (IL-10 and the IL-1RA). Lithium 38-45 interferon gamma Homo sapiens 151-159 10201115-2 1999 The N-terminal amino acid analysis of the purified proteins showed that: (a) the N-terminal methionine is processed more efficiently in E. coli LE392 rather than in E. coli XL1 cells; (b) the N-terminal methionine is removed better from the heterologous human interferon gamma in comparison with the homologous chloramphenicol acetyltransferase protein: and (c) there is no strong correlation between the efficiency of N-terminal procession and the yield of recombinant protein. Methionine 92-102 interferon gamma Homo sapiens 260-276 10079079-1 1999 We previously observed that IFN gamma-inducible expression of the human MHC class II, HLA-DR alpha, gene was enhanced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) only in human monocytic leukemia THP-1 cells, but not in HeLa cells. Tetradecanoylphorbol Acetate 174-177 interferon gamma Homo sapiens 28-37 10087182-0 1999 Dextran sulfate inhibits IFN-gamma-induced Jak-Stat pathway in human vascular endothelial cells. Dextran Sulfate 0-15 interferon gamma Homo sapiens 25-34 10087182-2 1999 Previously, dextran sulfate was shown to selectively inhibit expression of class II MHC by preventing transcription of the gene encoding CIITA, a transactivator protein required for IFN-gamma-inducible expression of class II genes. Dextran Sulfate 12-27 interferon gamma Homo sapiens 182-191 10087182-4 1999 Immunoprecipitation and Western blot analyses indicated that IFN-gamma-induced phosphorylation of Stat1 and Jak2 was blocked by dextran sulfate. Dextran Sulfate 128-143 interferon gamma Homo sapiens 61-70 10087182-6 1999 Binding of radiolabeled IFN-gamma to cells indicated that dextran sulfate may also modulate IFN-gamma interactions with the cell surface. Dextran Sulfate 58-73 interferon gamma Homo sapiens 24-33 10087182-6 1999 Binding of radiolabeled IFN-gamma to cells indicated that dextran sulfate may also modulate IFN-gamma interactions with the cell surface. Dextran Sulfate 58-73 interferon gamma Homo sapiens 92-101 10087182-7 1999 Thus, dextran sulfate is capable of interfering with the IFN-gamma-induced expression of class II MHC genes at multiple sites. Dextran Sulfate 6-21 interferon gamma Homo sapiens 57-66 10029571-0 1999 Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1. Tyrosine 112-120 interferon gamma Homo sapiens 43-81 10206118-10 1999 Neopterin, a marker of macrophage activation, increased in all but one patient treated with MDT + IFN-gamma but in none treated with MDT alone, indicating that IFN-gamma was active in vivo. Neopterin 0-9 interferon gamma Homo sapiens 98-107 10206118-10 1999 Neopterin, a marker of macrophage activation, increased in all but one patient treated with MDT + IFN-gamma but in none treated with MDT alone, indicating that IFN-gamma was active in vivo. Neopterin 0-9 interferon gamma Homo sapiens 160-169 10206118-10 1999 Neopterin, a marker of macrophage activation, increased in all but one patient treated with MDT + IFN-gamma but in none treated with MDT alone, indicating that IFN-gamma was active in vivo. mdt 92-95 interferon gamma Homo sapiens 160-169 10205001-2 1999 Activation of macrophages with lipopolysaccharide (LPS) and low doses of interferon-gamma (IFN-gamma) induced apoptotic death through a nitric oxide-dependent pathway. Nitric Oxide 136-148 interferon gamma Homo sapiens 73-100 10205001-7 1999 Moreover, incubation of activated macrophages with CsA and FK506 contributed to maintain higher levels of Bcl-2 than in LPS/IFN-gamma treated cells. Tacrolimus 59-64 interferon gamma Homo sapiens 124-133 10193428-2 1999 MS progressive patients showed an increased number of cells producing interferon-gamma (IFN-gamma) after activation with phorbol 12-myristate 13-acetate and ionomycin, compared with patients with clinically inactive forms (P < 0001) and with healthy controls (P = 0001). Tetradecanoylphorbol Acetate 121-152 interferon gamma Homo sapiens 70-86 10193428-2 1999 MS progressive patients showed an increased number of cells producing interferon-gamma (IFN-gamma) after activation with phorbol 12-myristate 13-acetate and ionomycin, compared with patients with clinically inactive forms (P < 0001) and with healthy controls (P = 0001). Tetradecanoylphorbol Acetate 121-152 interferon gamma Homo sapiens 88-97 10193428-2 1999 MS progressive patients showed an increased number of cells producing interferon-gamma (IFN-gamma) after activation with phorbol 12-myristate 13-acetate and ionomycin, compared with patients with clinically inactive forms (P < 0001) and with healthy controls (P = 0001). Ionomycin 157-166 interferon gamma Homo sapiens 70-86 10193428-2 1999 MS progressive patients showed an increased number of cells producing interferon-gamma (IFN-gamma) after activation with phorbol 12-myristate 13-acetate and ionomycin, compared with patients with clinically inactive forms (P < 0001) and with healthy controls (P = 0001). Ionomycin 157-166 interferon gamma Homo sapiens 88-97 10029571-7 1999 This was accomplished by preventing the IFN-induced tyrosine phosphorylation of STAT1, a component of both IFNalpha- and IFNgamma-induced DNA binding complexes. Tyrosine 52-60 interferon gamma Homo sapiens 121-129 10029571-8 1999 Therefore, IL-10 can directly inhibit STAT-dependent early response gene expression induced by both IFNalpha and IFNgamma in monocytes by suppressing the tyrosine phosphorylation of STAT1. Tyrosine 154-162 interferon gamma Homo sapiens 113-121 10089914-4 1999 Pretreatment with IFN-gamma for 72 hours enhanced the CH-11-induced apoptosis with up-regulation of Fas. 4-dimethylamino-3',4'-dimethoxychalcone 54-59 interferon gamma Homo sapiens 18-27 10348046-1 1999 Immunosuppressant 15-deoxyspergualin (DSG) inhibited induction of inducible nitric oxide synthase (iNOS) following stimulation with IFN-gamma and LPS in a cultured macrophage cell line, J774A.1 [corrected]. gusperimus 38-41 interferon gamma Homo sapiens 132-141 10233728-3 1999 Thus, in IFN-gamma-primed U937 cells, FcgammaRI aggregation results in an increase of PKC activity which is essentially calcium independent resulting from the translocation to the membrane of the novel PKCs, delta and epsilon, together with the atypical PKC zeta. Calcium 120-127 interferon gamma Homo sapiens 9-18 10348046-0 1999 Inhibition of nitric oxide synthase induction by 15-deoxyspergualin in a cultured macrophage cell line, J774A.1 [correction of J744A.1] activated with IFN-gamma and LPS. gusperimus 49-67 interferon gamma Homo sapiens 151-160 10348046-1 1999 Immunosuppressant 15-deoxyspergualin (DSG) inhibited induction of inducible nitric oxide synthase (iNOS) following stimulation with IFN-gamma and LPS in a cultured macrophage cell line, J774A.1 [corrected]. gusperimus 18-36 interferon gamma Homo sapiens 132-141 10022519-9 1999 Gel-shift assay data indicate a decrease in specific binding to AP-1 oligonucleotide of nuclear extract from IFN-gamma and PMA/IFN-gamma-treated cells. Oligonucleotides 69-84 interferon gamma Homo sapiens 109-118 10022519-9 1999 Gel-shift assay data indicate a decrease in specific binding to AP-1 oligonucleotide of nuclear extract from IFN-gamma and PMA/IFN-gamma-treated cells. Oligonucleotides 69-84 interferon gamma Homo sapiens 127-136 10190717-6 1999 RESULTS: Ribavirin enhanced a Type 1 (IL-2, IFNgamma, TNFalpha) while suppressing a Type 2 cytokine response (IL-4, IL-5 and IL-10), at the level of both protein and mRNA expression. Ribavirin 9-18 interferon gamma Homo sapiens 44-52 10080544-1 1999 Binding of interferon-gamma (IFN-gamma) to its heterodimeric receptor induces activation of the tyrosine kinases JAK1 and JAK2 followed by tyrosine phosphorylation of STAT1alpha. Tyrosine 96-104 interferon gamma Homo sapiens 11-27 10080544-1 1999 Binding of interferon-gamma (IFN-gamma) to its heterodimeric receptor induces activation of the tyrosine kinases JAK1 and JAK2 followed by tyrosine phosphorylation of STAT1alpha. Tyrosine 96-104 interferon gamma Homo sapiens 29-38 10080544-2 1999 Selective activation of STAT1alpha at the IFN-gamma receptor is achieved by specific interaction between a cytosolic tyrosine motif including Y440 in the IFN-gamma receptor alpha-chain and the SH2 domain of STAT1alpha. Tyrosine 117-125 interferon gamma Homo sapiens 42-51 10080544-2 1999 Selective activation of STAT1alpha at the IFN-gamma receptor is achieved by specific interaction between a cytosolic tyrosine motif including Y440 in the IFN-gamma receptor alpha-chain and the SH2 domain of STAT1alpha. Tyrosine 117-125 interferon gamma Homo sapiens 154-163 10206145-6 1999 In addition we found that the costimulation of RT4 cells with IL-1 and IFN-gamma results in the production of nitric oxide, and that in RT4 cells stimulated with both these cytokines, IDO activity and toxoplasmostasis was lower than in cells stimulated with IFN-gamma alone. Nitric Oxide 110-122 interferon gamma Homo sapiens 71-80 10206145-7 1999 This IL-1-mediated inhibition of IFN-gamma-induced IDO activity and toxoplasmostasis could be blocked by monomethyl L-arginine, an inhibitor of NO production. monomethyl l-arginine 105-126 interferon gamma Homo sapiens 33-42 9988719-5 1999 The PKR inhibitor 2-aminopurine (2-AP) inhibited TNF-alpha/IFN-gamma-induced NF-kappaB nuclear translocation in neuronal derived cells but not in endothelial cells. 2-Aminopurine 18-31 interferon gamma Homo sapiens 59-68 9988719-5 1999 The PKR inhibitor 2-aminopurine (2-AP) inhibited TNF-alpha/IFN-gamma-induced NF-kappaB nuclear translocation in neuronal derived cells but not in endothelial cells. 2-Aminopurine 33-37 interferon gamma Homo sapiens 59-68 9988719-6 1999 The induced degradation of IkappaBbeta, which is normally observed upon TNF-alpha/IFN-gamma cotreatment, was blocked completely by 2-AP in neuronal derived cells. 2-Aminopurine 131-135 interferon gamma Homo sapiens 82-91 9988719-7 1999 Also, 2-AP treatment or overexpression of a catalytically inactive PKR inhibited the TNF-alpha/IFN-gamma-induced synergistic activation of kappaB-dependent gene expression. 2-Aminopurine 6-10 interferon gamma Homo sapiens 95-104 9973476-7 1999 Results show that paraformaldehyde-fixed CD86+ T cells enhance the proliferation and production of IFN-gamma by anti-CD3 mAb-stimulated naive T cells and induce proliferation of resting allogenic T cells. paraform 18-34 interferon gamma Homo sapiens 99-108 10211553-3 1999 In this study, we wanted to investigate whether cisplatin interferes with the IL-2, IL-2 receptor (IL-2R), interferon (IFN)-gamma, and TNF-alpha expression in phytohemagglutinin-stimulated human peripheral blood lymphocytes. Cisplatin 48-57 interferon gamma Homo sapiens 107-129 10080629-2 1999 IFN-gamma and tritium-labeled IFN-gamma molecules formed either dimers (>90.5%) with the molecular mass of 60 kDa or probably tetramers (<9.5%) with the molecular mass of approximately 100 kDa in non-denaturing solvents, and no monomer was detected. Tritium 14-21 interferon gamma Homo sapiens 30-39 10025427-11 1999 CONCLUSION: Given that reduced interferon gamma binding might be related to lymphocyte activation, our data seem to demonstrate that the major effect of interferon beta-lb treatment is a decrease in T-cell activation. beta-lb 164-171 interferon gamma Homo sapiens 31-47 10211553-8 1999 However, cisplatin-treated cells displayed enhanced IL-2, IL-2R, IFN-gamma and TNF-alpha mRNA levels compared to drug-free controls. Cisplatin 9-18 interferon gamma Homo sapiens 65-74 10037193-7 1999 The objective of this study was to elucidate whether a Fas-dependent component exists in 5-fluorouracil (FUra)/leucovorin (LV)-induced cytotoxicity of colon carcinoma cells, and whether this may be potentiated by IFN-gamma-induced elevation in Fas expression, using the HT29 cell line as a model. ammonium ferrous sulfate 55-58 interferon gamma Homo sapiens 213-222 10037193-7 1999 The objective of this study was to elucidate whether a Fas-dependent component exists in 5-fluorouracil (FUra)/leucovorin (LV)-induced cytotoxicity of colon carcinoma cells, and whether this may be potentiated by IFN-gamma-induced elevation in Fas expression, using the HT29 cell line as a model. Fluorouracil 89-103 interferon gamma Homo sapiens 213-222 10037193-7 1999 The objective of this study was to elucidate whether a Fas-dependent component exists in 5-fluorouracil (FUra)/leucovorin (LV)-induced cytotoxicity of colon carcinoma cells, and whether this may be potentiated by IFN-gamma-induced elevation in Fas expression, using the HT29 cell line as a model. Leucovorin 123-125 interferon gamma Homo sapiens 213-222 10037193-9 1999 FUra/LV-induced cytotoxicity was significantly potentiated by IFN-gamma, reversed by exposure to NOK-1+NOK-2 antibodies, and correlated with a 4-fold induction of Fas expression in the presence of IFN-gamma and significant elevation in expression of FasL. fura/lv 0-7 interferon gamma Homo sapiens 62-71 10037193-9 1999 FUra/LV-induced cytotoxicity was significantly potentiated by IFN-gamma, reversed by exposure to NOK-1+NOK-2 antibodies, and correlated with a 4-fold induction of Fas expression in the presence of IFN-gamma and significant elevation in expression of FasL. fura/lv 0-7 interferon gamma Homo sapiens 197-206 10037193-11 1999 Like HT29 cells, this cytotoxicity was potentiated by IFN-gamma in GC3/c1 and VRC5/c1 but not in Caco2, which fails to express Fas, nor in HCT8 and HCT116, in which no dThd-dependent FUra-induced cytotoxicity was demonstrated. ammonium ferrous sulfate 127-130 interferon gamma Homo sapiens 54-63 10037193-11 1999 Like HT29 cells, this cytotoxicity was potentiated by IFN-gamma in GC3/c1 and VRC5/c1 but not in Caco2, which fails to express Fas, nor in HCT8 and HCT116, in which no dThd-dependent FUra-induced cytotoxicity was demonstrated. Thymidine 168-172 interferon gamma Homo sapiens 54-63 10037193-11 1999 Like HT29 cells, this cytotoxicity was potentiated by IFN-gamma in GC3/c1 and VRC5/c1 but not in Caco2, which fails to express Fas, nor in HCT8 and HCT116, in which no dThd-dependent FUra-induced cytotoxicity was demonstrated. Fluorouracil 183-187 interferon gamma Homo sapiens 54-63 10037193-12 1999 Data suggest that a Fas-dependent component, potentiated by IFN-gamma, exists in FUra/LV-induced cytotoxicity but requires FUra/LV-induced DNA damage for IFN-gamma-induced potentiation to occur. ammonium ferrous sulfate 20-23 interferon gamma Homo sapiens 60-69 10037193-12 1999 Data suggest that a Fas-dependent component, potentiated by IFN-gamma, exists in FUra/LV-induced cytotoxicity but requires FUra/LV-induced DNA damage for IFN-gamma-induced potentiation to occur. ammonium ferrous sulfate 20-23 interferon gamma Homo sapiens 154-163 10037193-12 1999 Data suggest that a Fas-dependent component, potentiated by IFN-gamma, exists in FUra/LV-induced cytotoxicity but requires FUra/LV-induced DNA damage for IFN-gamma-induced potentiation to occur. Fluorouracil 81-85 interferon gamma Homo sapiens 60-69 10037193-12 1999 Data suggest that a Fas-dependent component, potentiated by IFN-gamma, exists in FUra/LV-induced cytotoxicity but requires FUra/LV-induced DNA damage for IFN-gamma-induced potentiation to occur. Leucovorin 86-88 interferon gamma Homo sapiens 60-69 10037193-12 1999 Data suggest that a Fas-dependent component, potentiated by IFN-gamma, exists in FUra/LV-induced cytotoxicity but requires FUra/LV-induced DNA damage for IFN-gamma-induced potentiation to occur. Fluorouracil 81-86 interferon gamma Homo sapiens 60-69 10037193-12 1999 Data suggest that a Fas-dependent component, potentiated by IFN-gamma, exists in FUra/LV-induced cytotoxicity but requires FUra/LV-induced DNA damage for IFN-gamma-induced potentiation to occur. Leucovorin 128-130 interferon gamma Homo sapiens 154-163 10048787-1 1999 Interferon-gamma (IFN-gamma) has multiple effects on Ca2+ signalling in polymorphonuclear neutrophils (PMNs), including evoked cytosolic Ca2+ transients, increased capacitative calcium influx and increased sequestration of Ca2+ in intracellular stores. Calcium 177-184 interferon gamma Homo sapiens 0-16 10048787-1 1999 Interferon-gamma (IFN-gamma) has multiple effects on Ca2+ signalling in polymorphonuclear neutrophils (PMNs), including evoked cytosolic Ca2+ transients, increased capacitative calcium influx and increased sequestration of Ca2+ in intracellular stores. Calcium 177-184 interferon gamma Homo sapiens 18-27 10048787-6 1999 This store dependence of the IFN-gamma-induced Ca2+ signals was confirmed by the appearance of IFN-gamma-evoked Ca2+ signals in the presence of extracellular Ca2+ after store depletion by thapsigargin. Thapsigargin 188-200 interferon gamma Homo sapiens 29-38 10048787-6 1999 This store dependence of the IFN-gamma-induced Ca2+ signals was confirmed by the appearance of IFN-gamma-evoked Ca2+ signals in the presence of extracellular Ca2+ after store depletion by thapsigargin. Thapsigargin 188-200 interferon gamma Homo sapiens 95-104 10048787-7 1999 The appearance of IFN-gamma-mediated Ca2+-signals in the presence of EGTA indicates that IFN-gamma stimulates Ca2+ release from intracellular stores. Egtazic Acid 69-73 interferon gamma Homo sapiens 18-27 10048787-7 1999 The appearance of IFN-gamma-mediated Ca2+-signals in the presence of EGTA indicates that IFN-gamma stimulates Ca2+ release from intracellular stores. Egtazic Acid 69-73 interferon gamma Homo sapiens 89-98 10048787-9 1999 Although these latter results imply a role for inositol 1,4,5-trisphosphate(IP3) in IFN-gamma signalling, comparison of IFN-gamma-evoked responses with fMLP responses revealed clear differences that suggest different signal-transduction pathways. Inositol 1,4,5-Trisphosphate 47-75 interferon gamma Homo sapiens 84-93 10048787-9 1999 Although these latter results imply a role for inositol 1,4,5-trisphosphate(IP3) in IFN-gamma signalling, comparison of IFN-gamma-evoked responses with fMLP responses revealed clear differences that suggest different signal-transduction pathways. Inositol 1,4,5-Trisphosphate 76-79 interferon gamma Homo sapiens 84-93 10327605-4 1999 About one-half of [125I]hIFN-gamma binding could be displaced by heparin. Heparin 65-72 interferon gamma Homo sapiens 24-34 10327605-5 1999 The bound hIFN-gamma could be covalently cross-linked to the binding sites using disuccinylamide suberate, and the molecular weight range of these complexes was 200-800 kDa as determined by density gradient sedimentation and gel-exclusion chromatography. disuccinylamide 81-96 interferon gamma Homo sapiens 10-20 10327605-8 1999 The detergent-insoluble Manduca hIFN-gamma binding was bimodal and similar in affinity distribution to the binding found with human platelet membranes (Kdiss range 0.1-2 nM). kdiss 152-157 interferon gamma Homo sapiens 32-42 10327605-9 1999 The detergent-solubilized IFN-gamma sites were homogenous, with a Kdiss of about 1.5 nM. kdiss 66-71 interferon gamma Homo sapiens 26-35 10065757-0 1999 Interleukin-4 and interferon-gamma inhibit prostaglandin production by interleukin-1beta-stimulated human periodontal ligament fibroblasts. Prostaglandins 43-56 interferon gamma Homo sapiens 18-34 10048787-10 1999 However, responses to fMLP and IFN-gamma were both depressed by pertussis toxin, and the IFN-gamma responses were, in addition, inhibited by the tyrosine kinase inhibitor genistein. Genistein 171-180 interferon gamma Homo sapiens 89-98 10065757-6 1999 IL-4 and IFN-gamma suppressed PGE2 production by IL-1beta-stimulated PDL fibroblasts, but COX activity enhanced by IL-1beta treatment was significantly inhibited by IL-4, not by IFN-gamma. Dinoprostone 30-34 interferon gamma Homo sapiens 9-18 10224470-7 1999 RESULTS: We show that binding of IFN-gamma to human eosinophils initiated a series of events that resulted in the rapid tyrosine phosphorylation of not only the IFN-gammaRalpha chain but also Jak1, Jak2, and Stat1alpha. Tyrosine 120-128 interferon gamma Homo sapiens 33-42 9931185-3 1999 Human leukocyte antigen-DR gene expression on monocytes and serum neopterin increased after administration of IFN-gamma (P < 0.05 vs. control). Neopterin 66-75 interferon gamma Homo sapiens 110-119 10064070-5 1999 Cyclosporin A inhibits TCR-induced IFN-gamma production, but not IL-12/IL-18-induced IFN-gamma production, biochemically discriminating between these pathways. Cyclosporine 0-13 interferon gamma Homo sapiens 35-44 10191628-4 1999 Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha. Tetradecanoylphorbol Acetate 100-103 interferon gamma Homo sapiens 181-190 9949326-0 1999 Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-gamma production of T cells. Histamine 21-30 interferon gamma Homo sapiens 166-175 9949326-0 1999 Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-gamma production of T cells. sulfidoleukotrienes 35-54 interferon gamma Homo sapiens 166-175 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. vit 197-200 interferon gamma Homo sapiens 52-61 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. vit 197-200 interferon gamma Homo sapiens 124-133 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. vit 197-200 interferon gamma Homo sapiens 124-133 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. Histamine 322-331 interferon gamma Homo sapiens 52-61 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. Histamine 322-331 interferon gamma Homo sapiens 124-133 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. Histamine 322-331 interferon gamma Homo sapiens 124-133 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. sulfidoleukotriene 336-354 interferon gamma Homo sapiens 52-61 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. sulfidoleukotriene 336-354 interferon gamma Homo sapiens 124-133 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. sulfidoleukotriene 336-354 interferon gamma Homo sapiens 124-133 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. vit 370-373 interferon gamma Homo sapiens 52-61 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. vit 370-373 interferon gamma Homo sapiens 124-133 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. vit 370-373 interferon gamma Homo sapiens 124-133 9949326-9 1999 CONCLUSION: These data indicate that T cells (producing IL-10 and IFN-gamma after VIT) play a key role for the inhibition of histamine and sulfidoleukotriene release of effector cells. Histamine 125-134 interferon gamma Homo sapiens 66-75 9949326-9 1999 CONCLUSION: These data indicate that T cells (producing IL-10 and IFN-gamma after VIT) play a key role for the inhibition of histamine and sulfidoleukotriene release of effector cells. sulfidoleukotriene 139-157 interferon gamma Homo sapiens 66-75 9950598-7 1999 The number of T cells staining for IL-3 and IL-5 was reduced, although not to statistical significance, but there was a significant reduction in the number of T cells expressing IL-2 and IFN-gamma (P = 0.03) after CsA treatment compared with initial values. Cyclosporine 214-217 interferon gamma Homo sapiens 187-196 9950598-10 1999 CONCLUSIONS: The in vitro effects of CsA translate into a reduction in T cells, a normalization of the CD4-CD8 ratio, a decrease in T-cell activation, and a reduction in T-cell cytokine expression, especially IL-2 and IFN-gamma. Cyclosporine 37-40 interferon gamma Homo sapiens 218-227 10090397-3 1999 Using a three-cytokine mixture (TNF-alpha, IL-1beta, and IFN-gamma) that could maximally induce both iNOS and sPLA2, the increase in these mRNA species reached a maximum by 4-8 h, followed by a decline up to 48 h. L-N6-(1-Iminoethyl)lysine acetate (L-NIL) inhibited cytokine-induced NO production with IC50 of 25 microM, but this compound did not affect iNOS mRNA. l-n6-(1-iminoethyl)lysine acetate 214-247 interferon gamma Homo sapiens 57-66 10090397-3 1999 Using a three-cytokine mixture (TNF-alpha, IL-1beta, and IFN-gamma) that could maximally induce both iNOS and sPLA2, the increase in these mRNA species reached a maximum by 4-8 h, followed by a decline up to 48 h. L-N6-(1-Iminoethyl)lysine acetate (L-NIL) inhibited cytokine-induced NO production with IC50 of 25 microM, but this compound did not affect iNOS mRNA. L-NIL 249-254 interferon gamma Homo sapiens 57-66 10191628-4 1999 Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha. Ionomycin 108-117 interferon gamma Homo sapiens 181-190 9880560-3 1999 IL-1, TNF-alpha, IFN-gamma, and exogenous sodium nitroprusside, a nitric oxide donor, all stimulated PGE2 production in a dose-dependent manner. Dinoprostone 101-105 interferon gamma Homo sapiens 17-26 10075021-0 1999 Interleukin-4-mediated inhibition of nitric oxide production in interferon-gamma-treated and virus-infected macrophages. Nitric Oxide 37-49 interferon gamma Homo sapiens 64-80 9916749-0 1999 Antigen-dependent and -independent IFN-gamma modulation by penicillins. Penicillins 59-70 interferon gamma Homo sapiens 35-44 9916720-3 1999 Inhibition by IFN-gamma, and to a lesser extent IFN-beta, was almost completely reversed by addition of L-tryptophan to the culture medium, strongly implicating the indoleamine 2,3 dioxygenase (IDO) pathway. Tryptophan 104-116 interferon gamma Homo sapiens 14-23 10721098-0 1999 Antioxidant activities and redox regulation of interferon-gamma-induced tryptophan metabolism in human monocytes and macrophages. Tryptophan 72-82 interferon gamma Homo sapiens 47-63 10721098-1 1999 This article summarises studies supporting the proposal that induction of L-tryptophan (Trp) degradation along the kynurenine pathway in human monocytes and macrophages by interferon-gamma (IFN gamma) represents a novel extracellular antioxidant defence that acts to prevent inadvertent oxidative damage to host tissue during inflammation. Tryptophan 74-86 interferon gamma Homo sapiens 172-188 10721098-1 1999 This article summarises studies supporting the proposal that induction of L-tryptophan (Trp) degradation along the kynurenine pathway in human monocytes and macrophages by interferon-gamma (IFN gamma) represents a novel extracellular antioxidant defence that acts to prevent inadvertent oxidative damage to host tissue during inflammation. Tryptophan 74-86 interferon gamma Homo sapiens 190-199 10721098-1 1999 This article summarises studies supporting the proposal that induction of L-tryptophan (Trp) degradation along the kynurenine pathway in human monocytes and macrophages by interferon-gamma (IFN gamma) represents a novel extracellular antioxidant defence that acts to prevent inadvertent oxidative damage to host tissue during inflammation. Tryptophan 88-91 interferon gamma Homo sapiens 172-188 10721098-1 1999 This article summarises studies supporting the proposal that induction of L-tryptophan (Trp) degradation along the kynurenine pathway in human monocytes and macrophages by interferon-gamma (IFN gamma) represents a novel extracellular antioxidant defence that acts to prevent inadvertent oxidative damage to host tissue during inflammation. Tryptophan 88-91 interferon gamma Homo sapiens 190-199 10721098-1 1999 This article summarises studies supporting the proposal that induction of L-tryptophan (Trp) degradation along the kynurenine pathway in human monocytes and macrophages by interferon-gamma (IFN gamma) represents a novel extracellular antioxidant defence that acts to prevent inadvertent oxidative damage to host tissue during inflammation. Kynurenine 115-125 interferon gamma Homo sapiens 172-188 10721098-1 1999 This article summarises studies supporting the proposal that induction of L-tryptophan (Trp) degradation along the kynurenine pathway in human monocytes and macrophages by interferon-gamma (IFN gamma) represents a novel extracellular antioxidant defence that acts to prevent inadvertent oxidative damage to host tissue during inflammation. Kynurenine 115-125 interferon gamma Homo sapiens 190-199 10721098-2 1999 The studies show that formation and release of the aminophenolic antioxidant 3-hydroxyanthranilic acid (3-HAA) is responsible for the ability of IFN gamma-primed human macrophages to inhibit the oxidation of low density lipoprotein (LDL); an event implicated as an important event in atherogenesis. 3-Hydroxyanthranilic Acid 77-102 interferon gamma Homo sapiens 145-154 10721098-2 1999 The studies show that formation and release of the aminophenolic antioxidant 3-hydroxyanthranilic acid (3-HAA) is responsible for the ability of IFN gamma-primed human macrophages to inhibit the oxidation of low density lipoprotein (LDL); an event implicated as an important event in atherogenesis. 3-Hydroxyanthranilic Acid 104-109 interferon gamma Homo sapiens 145-154 10721098-5 1999 Nitric oxide inhibits IDO activity in IFN gamma-primed human macrophages and this may represent a physiological regulatory mechanism of the dioxygenase during inflammation. Nitric Oxide 0-12 interferon gamma Homo sapiens 38-47 10721136-2 1999 Tryptophan is converted to kynurenine by the action of the enzyme indoleamine 2,3-dioxygenase induced by interferon-gamma (IFN-gamma). Tryptophan 0-10 interferon gamma Homo sapiens 105-121 10721136-2 1999 Tryptophan is converted to kynurenine by the action of the enzyme indoleamine 2,3-dioxygenase induced by interferon-gamma (IFN-gamma). Tryptophan 0-10 interferon gamma Homo sapiens 123-132 10721136-2 1999 Tryptophan is converted to kynurenine by the action of the enzyme indoleamine 2,3-dioxygenase induced by interferon-gamma (IFN-gamma). Kynurenine 27-37 interferon gamma Homo sapiens 105-121 10721136-2 1999 Tryptophan is converted to kynurenine by the action of the enzyme indoleamine 2,3-dioxygenase induced by interferon-gamma (IFN-gamma). Kynurenine 27-37 interferon gamma Homo sapiens 123-132 10721136-3 1999 Since IFN-gamma is a Th1-cell derived cytokine, an increased tryptophan degradation rate via the kynurenine pathway can be found when the cellular immune system is activated as it is, e.g., in viral infections or in autoimmune diseases. Tryptophan 61-71 interferon gamma Homo sapiens 6-15 10721136-3 1999 Since IFN-gamma is a Th1-cell derived cytokine, an increased tryptophan degradation rate via the kynurenine pathway can be found when the cellular immune system is activated as it is, e.g., in viral infections or in autoimmune diseases. Kynurenine 97-107 interferon gamma Homo sapiens 6-15 10721136-4 1999 Thus, the ratio kynurenine per tryptophan provides a possibility to estimate IFN-gamma activity in vivo and furthermore reflects the degree of immune activation. Kynurenine 16-26 interferon gamma Homo sapiens 77-86 10721136-4 1999 Thus, the ratio kynurenine per tryptophan provides a possibility to estimate IFN-gamma activity in vivo and furthermore reflects the degree of immune activation. Tryptophan 31-41 interferon gamma Homo sapiens 77-86 10654431-0 1999 Tetracycline-controlled expression of glycosylated porcine interferon-gamma in mammalian cells. Tetracycline 0-12 interferon gamma Homo sapiens 59-75 11148756-2 1999 Our test system is based on the stimulation of IFN-gamma-primed human (THP-1) and murine (J774A.1 and RAW 264.7) monocytic cell lines by bacterial pyrogens to form neopterin or nitrite, respectively. Neopterin 164-173 interferon gamma Homo sapiens 47-56 11148756-2 1999 Our test system is based on the stimulation of IFN-gamma-primed human (THP-1) and murine (J774A.1 and RAW 264.7) monocytic cell lines by bacterial pyrogens to form neopterin or nitrite, respectively. Nitrites 177-184 interferon gamma Homo sapiens 47-56 10343540-0 1999 The immune suppressive effect of dexamethasone in rheumatoid arthritis is accompanied by upregulation of interleukin 10 and by differential changes in interferon gamma and interleukin 4 production. Dexamethasone 33-46 interferon gamma Homo sapiens 151-167 10654431-1 1999 Tetracycline-controlled expression plasmids that allow inducible expression of proteins in mammalian cells (Gossen & Bujard, 1992), have been used to express porcine interferon-gamma in the RK-13 rabbit kidney cell line. Tetracycline 0-12 interferon gamma Homo sapiens 170-186 9892783-10 1999 The ability to influence the IFN-gamma release during an immune response could be one of the primary means by which the fluoride ion influences the immune system. Fluorides 120-128 interferon gamma Homo sapiens 29-38 10654431-5 1999 Molecular weight comparison of 35S-Methionine, labelled rGPoIFN-gamma with natural leukocytic IFN-gamma after immunoprecipitation, revealed 4 major glycoforms with apparent Mr of 27,000; 25,000; 20,000 and 18,500, that are almost identical in both IFN-gamma species. 35s-methionine 31-45 interferon gamma Homo sapiens 60-69 10233688-3 1999 Interferon-gamma (IFN-gamma) completely overcame the enhancement of serotonin release and suppression of nitrite production induced by IL-4. Serotonin 68-77 interferon gamma Homo sapiens 0-16 9892219-5 1999 The combination of interleukin-1beta (IL-1beta) plus interferon-gamma (IFN-gamma) increased nitric oxide production 12-fold while stimulating mRNA expression of inducible nitric oxide synthase (iNOS). Nitric Oxide 92-104 interferon gamma Homo sapiens 53-69 9892219-5 1999 The combination of interleukin-1beta (IL-1beta) plus interferon-gamma (IFN-gamma) increased nitric oxide production 12-fold while stimulating mRNA expression of inducible nitric oxide synthase (iNOS). Nitric Oxide 92-104 interferon gamma Homo sapiens 71-80 10233688-3 1999 Interferon-gamma (IFN-gamma) completely overcame the enhancement of serotonin release and suppression of nitrite production induced by IL-4. Serotonin 68-77 interferon gamma Homo sapiens 18-27 10233688-3 1999 Interferon-gamma (IFN-gamma) completely overcame the enhancement of serotonin release and suppression of nitrite production induced by IL-4. Nitrites 105-112 interferon gamma Homo sapiens 0-16 10075275-6 1999 Investigation of a potential underlying mechanism of anti-enterococcal action of IFN-gamma reveals that it is, most probably, largely due to an activated secretion of the microbicidal reactive oxygen intermediates by neutrophils. Oxygen 193-199 interferon gamma Homo sapiens 81-90 10233688-3 1999 Interferon-gamma (IFN-gamma) completely overcame the enhancement of serotonin release and suppression of nitrite production induced by IL-4. Nitrites 105-112 interferon gamma Homo sapiens 18-27 10233688-4 1999 Over several experiments, with or without IL-4 and/or IFN-gamma, serotonin release correlated inversely with nitrite production. Nitrites 109-116 interferon gamma Homo sapiens 54-63 10233688-7 1999 We conclude that IL-4 and IFN-gamma reciprocally regulate mast cell secretory responsiveness via control of nitric oxide synthesis by accessory cells; the nitric oxide effect on mast cells is direct but does not involve cyclic GMP or peroxynitrite. Nitric Oxide 108-120 interferon gamma Homo sapiens 26-35 10233688-7 1999 We conclude that IL-4 and IFN-gamma reciprocally regulate mast cell secretory responsiveness via control of nitric oxide synthesis by accessory cells; the nitric oxide effect on mast cells is direct but does not involve cyclic GMP or peroxynitrite. Nitric Oxide 155-167 interferon gamma Homo sapiens 26-35 11254026-3 1999 We showed that 10 micromol 17-beta-estradiol (E2) and 1-10 micromol ginsenoside Rg1 (Rg1) could prevent the toxicity of Abeta25-35 and/or IFN-gamma to microglias, inhibit the microglial respiratory burst activity and decrease the accumulation of NO. Estradiol 27-44 interferon gamma Homo sapiens 138-147 10529600-8 1999 Dex, CHX or theophylline dose-dependently decreased CD62L expression on IFN-gamma-stimulated eosinophils. Dexamethasone 0-3 interferon gamma Homo sapiens 72-81 10529600-8 1999 Dex, CHX or theophylline dose-dependently decreased CD62L expression on IFN-gamma-stimulated eosinophils. Theophylline 12-24 interferon gamma Homo sapiens 72-81 10529600-10 1999 It is suggested that protein synthesis and intracellular cAMP participate in the increase in L-selectin expression on IFN-gamma-stimulated eosinophils. Cyclic AMP 57-61 interferon gamma Homo sapiens 118-127 10592110-0 1999 Inducible nitric oxide synthase and nitric oxide production in Leishmania infantum-infected human macrophages stimulated with interferon-gamma and bacterial lipopolysaccharide. Nitric Oxide 10-22 interferon gamma Homo sapiens 126-142 11254026-3 1999 We showed that 10 micromol 17-beta-estradiol (E2) and 1-10 micromol ginsenoside Rg1 (Rg1) could prevent the toxicity of Abeta25-35 and/or IFN-gamma to microglias, inhibit the microglial respiratory burst activity and decrease the accumulation of NO. Ginsenosides 68-79 interferon gamma Homo sapiens 138-147 9886425-3 1999 Skin affected with ACD to nickel and skin-derived, nickel-specific CD4+ T cell lines expressed IFN-gamma, TNF-alpha, and IL-17 mRNAs. Nickel 51-57 interferon gamma Homo sapiens 95-104 9867857-3 1999 We show in this study that nuclear localization of IFN-gamma is driven by a simple polybasic nuclear localization sequence (NLS) in its COOH terminus, as verified by its ability to specify nuclear import of a heterologous protein allophycocyanin (APC) in standard import assays in digitonin-permeabilized cells. Carbonic Acid 136-140 interferon gamma Homo sapiens 51-60 9867857-3 1999 We show in this study that nuclear localization of IFN-gamma is driven by a simple polybasic nuclear localization sequence (NLS) in its COOH terminus, as verified by its ability to specify nuclear import of a heterologous protein allophycocyanin (APC) in standard import assays in digitonin-permeabilized cells. Digitonin 281-290 interferon gamma Homo sapiens 51-60 9867857-4 1999 Similar to other nuclear import signals, we show that a peptide representing amino acids 95-132 of IFN-gamma (IFN-gamma(95-132)) containing the polybasic sequence 126RKRKRSR132 was capable of specifying nuclear uptake of the autofluorescent protein, APC, in an energy-dependent fashion that required both ATP and GTP. Adenosine Triphosphate 305-308 interferon gamma Homo sapiens 99-108 9867857-4 1999 Similar to other nuclear import signals, we show that a peptide representing amino acids 95-132 of IFN-gamma (IFN-gamma(95-132)) containing the polybasic sequence 126RKRKRSR132 was capable of specifying nuclear uptake of the autofluorescent protein, APC, in an energy-dependent fashion that required both ATP and GTP. Adenosine Triphosphate 305-308 interferon gamma Homo sapiens 110-119 9867857-4 1999 Similar to other nuclear import signals, we show that a peptide representing amino acids 95-132 of IFN-gamma (IFN-gamma(95-132)) containing the polybasic sequence 126RKRKRSR132 was capable of specifying nuclear uptake of the autofluorescent protein, APC, in an energy-dependent fashion that required both ATP and GTP. Guanosine Triphosphate 313-316 interferon gamma Homo sapiens 99-108 9867857-4 1999 Similar to other nuclear import signals, we show that a peptide representing amino acids 95-132 of IFN-gamma (IFN-gamma(95-132)) containing the polybasic sequence 126RKRKRSR132 was capable of specifying nuclear uptake of the autofluorescent protein, APC, in an energy-dependent fashion that required both ATP and GTP. Guanosine Triphosphate 313-316 interferon gamma Homo sapiens 110-119 9886425-4 1999 Four of seven nickel-specific CD4+ T cell clones positive for the skin-homing receptor, cutaneous lymphocyte-associated Ag, were shown to corelease IL-17, IFN-gamma, and TNF-alpha. Nickel 14-20 interferon gamma Homo sapiens 155-164 9924702-6 1999 This unresponsive state in T-PBL appeared selective because IFN-gamma was produced when cells were stimulated with either phytohemagglutinin or anti-CD3 antibody. t-pbl 27-32 interferon gamma Homo sapiens 60-69 10658822-2 1999 SIN-1 or macrophages activated by lipopolysaccharide plus interferon-gamma induced a significant glutathione decrease in ECV 304 cells. Glutathione 97-108 interferon gamma Homo sapiens 58-74 12938514-1 1999 To understand the effect of rh-IFN-gamma on the ability of curcumin to kill HL-60 cells in vitro, the myeloid leukemic cell line HL-60 was studied by using cell culture. Curcumin 59-67 interferon gamma Homo sapiens 31-40 12938514-12 1999 It is concluded that IFN-gamma can enhance the antiproliferative ability of curcumin against HL-60 cells. Curcumin 76-84 interferon gamma Homo sapiens 21-30 10656176-3 1999 Pretreatment of MRC-5 and phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells with IFN-alpha or IFN-gamma for 24 hr prior to the infection reduced the number of infected cells and virus yield. Tetradecanoylphorbol Acetate 26-57 interferon gamma Homo sapiens 102-111 10656176-3 1999 Pretreatment of MRC-5 and phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells with IFN-alpha or IFN-gamma for 24 hr prior to the infection reduced the number of infected cells and virus yield. Tetradecanoylphorbol Acetate 59-62 interferon gamma Homo sapiens 102-111 10656176-7 1999 The current study shows that IFN-alpha and IFN-gamma can play a role in the reduction of HCMV replication in macrophage-like cells and in the efficiency of therapies with ganciclovir in this cell type and that the anti-CMV effect of cytokines may be different in fibroblasts and in macrophage-like cells. Ganciclovir 171-182 interferon gamma Homo sapiens 43-52 9852039-5 1998 Elevated protein expression was detected as early as 6 h following IFN-gamma and was maximal at 24 h. Following IFN-gamma, membrane association of Rab5a:GTP was substantially increased. Guanosine Triphosphate 153-156 interferon gamma Homo sapiens 67-76 9857002-6 1998 Despite elimination of both strong NFAT-binding sites, the IFN-gamma promoter remained completely sensitive to inhibition by cyclosporin. Cyclosporine 125-136 interferon gamma Homo sapiens 59-68 9857002-7 1998 This suggests that other elements in the IFN-gamma promoter, such as the IFN-gamma proximal element, are sufficient for cyclosporin sensitivity of this gene. Cyclosporine 120-131 interferon gamma Homo sapiens 41-50 9857002-7 1998 This suggests that other elements in the IFN-gamma promoter, such as the IFN-gamma proximal element, are sufficient for cyclosporin sensitivity of this gene. Cyclosporine 120-131 interferon gamma Homo sapiens 73-82 9852039-5 1998 Elevated protein expression was detected as early as 6 h following IFN-gamma and was maximal at 24 h. Following IFN-gamma, membrane association of Rab5a:GTP was substantially increased. Guanosine Triphosphate 153-156 interferon gamma Homo sapiens 112-121 9852039-10 1998 Last, guanine nucleotide exchange on Rab5a was elevated about 3-fold in the presence of cytosol from IFN-gamma-treated cells. Guanine Nucleotides 6-24 interferon gamma Homo sapiens 101-110 9865744-6 1998 Four additional cell lines exhibited Fas-mediated apoptosis after preincubation with IFN-gamma and/or cycloheximide, whereas two cell lines were resistant to Fas-mediated killing. ammonium ferrous sulfate 37-40 interferon gamma Homo sapiens 85-94 9892033-7 1998 In addition, both terfenadine and fexofenadine were able to decrease soluble ICAM-1 levels in IFN gamma-stimulated WK cells. Terfenadine 18-29 interferon gamma Homo sapiens 94-103 9928254-2 1998 iNOS can be induced by transcriptional activation to produce nitric oxide (NO) in response to a challenge with the pro-inflammatory cytokines TNF-alpha and IFN-gamma. Nitric Oxide 61-73 interferon gamma Homo sapiens 156-165 9892033-7 1998 In addition, both terfenadine and fexofenadine were able to decrease soluble ICAM-1 levels in IFN gamma-stimulated WK cells. fexofenadine 34-46 interferon gamma Homo sapiens 94-103 9892033-8 1998 On HEL fibroblasts, fexofenadine only was able to inhibit ICAM-1 upregulation induced by IFN gamma. fexofenadine 20-32 interferon gamma Homo sapiens 89-98 9877329-0 1998 Inhibition of the synthesis of eicosanoid-like substances in a human oral cancer cell line by interferon-gamma and eicosapentaenoic acid. Eicosanoids 31-41 interferon gamma Homo sapiens 94-110 9877329-11 1998 These results demonstrate that two eicosanoid-like compounds are synthesized by the OEC-M cell line and that their production can be modulated by IFN-gamma, EPA, indomethacin, NDGA, ETYA, and dexamethasone. Eicosanoids 35-45 interferon gamma Homo sapiens 146-155 10049522-4 1998 A significant and dramatic increase in IFN-gamma levels was associated with a favourable response to therapy in the IFNs-treated patients, mainly in the group of Tamoxifen. Tamoxifen 162-171 interferon gamma Homo sapiens 39-48 10099468-0 1998 Monitoring recombinant human interferon-gamma N-glycosylation during perfused fluidized-bed and stirred-tank batch culture of CHO cells. Nitrogen 46-47 interferon gamma Homo sapiens 29-45 9875677-3 1998 The cultivation of human peripheral blood mononuclear cells (PBMC) in the presence of cisplatin (0-1.0 microg/ml) or 5-FU (0-5.0 microg/ml) resulted in the significant augmentation of natural killer (NK) and lymphokine-activated killer (LAK) cell activities as well as generation of interferon (IFN) gamma, tumor necrosis factor (TNF) alpha, beta interleukin(IL)-1beta, IL-6 and IL-12 in vitro. Cisplatin 86-95 interferon gamma Homo sapiens 283-305 9875677-3 1998 The cultivation of human peripheral blood mononuclear cells (PBMC) in the presence of cisplatin (0-1.0 microg/ml) or 5-FU (0-5.0 microg/ml) resulted in the significant augmentation of natural killer (NK) and lymphokine-activated killer (LAK) cell activities as well as generation of interferon (IFN) gamma, tumor necrosis factor (TNF) alpha, beta interleukin(IL)-1beta, IL-6 and IL-12 in vitro. Fluorouracil 117-121 interferon gamma Homo sapiens 283-305 9875677-6 1998 Furthermore, high levels of NK and LAK activities and significant increases of the numbers of cells positive for asialoGM1, IFNgamma, TNFalpha, or IL-1beta were detected in the spleen cells derived from animals given cisplatin or 5-FU as compared with those given saline (P < 0.001-0.05). Cisplatin 217-226 interferon gamma Homo sapiens 124-132 9890714-7 1998 The inhibitory efficiency of 117-10C was found to be 6-fold that of scFv in an interferon gamma (IFN-gamma)-inducing assay on the IL-18-responsive cell line KG-1. 117-10c 29-36 interferon gamma Homo sapiens 79-106 9834094-3 1998 Precursor Th cells (pTh) contain high levels of cAMP response element binding protein-activation transcription factor-1 (CREB-ATF1) proteins that bind these promoter elements from the IFN-gamma gene, and these cells fail to express promoter activity. Cyclic AMP 48-52 interferon gamma Homo sapiens 184-193 9834094-6 1998 IL-12-stimulated Thl differentiation increases dist.IFN-gamma activity in restimulated eTh1 cells; eTh1 nuclear extracts form increased levels of Jun-ATF2-dist.IFN-gamma complexes. Orlistat 17-20 interferon gamma Homo sapiens 52-61 9834094-6 1998 IL-12-stimulated Thl differentiation increases dist.IFN-gamma activity in restimulated eTh1 cells; eTh1 nuclear extracts form increased levels of Jun-ATF2-dist.IFN-gamma complexes. Orlistat 17-20 interferon gamma Homo sapiens 160-169 9877450-4 1998 The current investigation examined the effects of dexamethasone (DEX) mimicking basal, stress, and supraphysiologic levels of cortisol on production of interferon-gamma (IFN-gamma) (type-1), interleukin (IL)-12p40 (type 1), IL-10 (type 2), and IL-4 (type 2) by human PBMC. Dexamethasone 50-63 interferon gamma Homo sapiens 152-168 9877450-4 1998 The current investigation examined the effects of dexamethasone (DEX) mimicking basal, stress, and supraphysiologic levels of cortisol on production of interferon-gamma (IFN-gamma) (type-1), interleukin (IL)-12p40 (type 1), IL-10 (type 2), and IL-4 (type 2) by human PBMC. Dexamethasone 50-63 interferon gamma Homo sapiens 170-179 9877450-4 1998 The current investigation examined the effects of dexamethasone (DEX) mimicking basal, stress, and supraphysiologic levels of cortisol on production of interferon-gamma (IFN-gamma) (type-1), interleukin (IL)-12p40 (type 1), IL-10 (type 2), and IL-4 (type 2) by human PBMC. Dexamethasone 65-68 interferon gamma Homo sapiens 152-168 9876227-3 1998 Purified CD45RO CD4 T cells stimulated with PMA and ionomycin secreted higher levels of IL-4 and IFN-gamma, as measured by ELISA, than CD45RA CD4 T cells which secreted little IL-4 or IFN-gamma. Ionomycin 52-61 interferon gamma Homo sapiens 97-106 9877450-4 1998 The current investigation examined the effects of dexamethasone (DEX) mimicking basal, stress, and supraphysiologic levels of cortisol on production of interferon-gamma (IFN-gamma) (type-1), interleukin (IL)-12p40 (type 1), IL-10 (type 2), and IL-4 (type 2) by human PBMC. Dexamethasone 65-68 interferon gamma Homo sapiens 170-179 9876227-3 1998 Purified CD45RO CD4 T cells stimulated with PMA and ionomycin secreted higher levels of IL-4 and IFN-gamma, as measured by ELISA, than CD45RA CD4 T cells which secreted little IL-4 or IFN-gamma. Ionomycin 52-61 interferon gamma Homo sapiens 184-193 9877450-4 1998 The current investigation examined the effects of dexamethasone (DEX) mimicking basal, stress, and supraphysiologic levels of cortisol on production of interferon-gamma (IFN-gamma) (type-1), interleukin (IL)-12p40 (type 1), IL-10 (type 2), and IL-4 (type 2) by human PBMC. Hydrocortisone 126-134 interferon gamma Homo sapiens 152-168 9877450-4 1998 The current investigation examined the effects of dexamethasone (DEX) mimicking basal, stress, and supraphysiologic levels of cortisol on production of interferon-gamma (IFN-gamma) (type-1), interleukin (IL)-12p40 (type 1), IL-10 (type 2), and IL-4 (type 2) by human PBMC. Hydrocortisone 126-134 interferon gamma Homo sapiens 170-179 9856819-3 1998 Using Brefeldin A to induce short-term intracellular accumulation of IFN-gamma in T cells capable of IFN-gamma production, we found that 90% of psoriatic patients have IFN-gamma-producing T cells at a greater proportion of their CD3+ cells than normals, with a mean of 16%+/-3%, as compared with 4%+/-2% in normal epidermis (p = 0.01). Brefeldin A 6-17 interferon gamma Homo sapiens 69-78 9856819-3 1998 Using Brefeldin A to induce short-term intracellular accumulation of IFN-gamma in T cells capable of IFN-gamma production, we found that 90% of psoriatic patients have IFN-gamma-producing T cells at a greater proportion of their CD3+ cells than normals, with a mean of 16%+/-3%, as compared with 4%+/-2% in normal epidermis (p = 0.01). Brefeldin A 6-17 interferon gamma Homo sapiens 101-110 9856819-3 1998 Using Brefeldin A to induce short-term intracellular accumulation of IFN-gamma in T cells capable of IFN-gamma production, we found that 90% of psoriatic patients have IFN-gamma-producing T cells at a greater proportion of their CD3+ cells than normals, with a mean of 16%+/-3%, as compared with 4%+/-2% in normal epidermis (p = 0.01). Brefeldin A 6-17 interferon gamma Homo sapiens 101-110 9825824-0 1998 Sulfation-dependent down-regulation of interferon-gamma-induced major histocompatibility complex class I and II and intercellular adhesion molecule-1 expression on tubular and endothelial cells by glycosaminoglycans. Glycosaminoglycans 197-215 interferon gamma Homo sapiens 39-55 9804758-2 1998 Activation of STAT1 by IFNalpha or IFNgamma through its tyrosine phosphorylation involves members of the Jak tyrosine kinases. Tyrosine 56-64 interferon gamma Homo sapiens 35-43 9825824-1 1998 BACKGROUND: Previously, it has been demonstrated that heparin inhibits major histocompatibility complex (MHC) class II and intercellular adhesion molecule-1 (ICAM-1) expression on interferon-gamma (IFN-gamma)-stimulated human umbilical vein endothelial cells (HUVECs). Heparin 54-61 interferon gamma Homo sapiens 180-196 9825824-1 1998 BACKGROUND: Previously, it has been demonstrated that heparin inhibits major histocompatibility complex (MHC) class II and intercellular adhesion molecule-1 (ICAM-1) expression on interferon-gamma (IFN-gamma)-stimulated human umbilical vein endothelial cells (HUVECs). Heparin 54-61 interferon gamma Homo sapiens 198-207 9825824-3 1998 We also studied whether the degree of sulfation of heparin is of relevance for the binding to IFN-gamma and inhibition of MHC and ICAM-1 expression after IFN-gamma stimulation. Heparin 51-58 interferon gamma Homo sapiens 94-103 9825824-6 1998 RESULTS: Heparin was able to inhibit the up-regulation of MHC and ICAM-1 in a dose-dependent fashion on both IFN-gamma-stimulated HUVECs and PTECs. Heparin 9-16 interferon gamma Homo sapiens 109-118 9825824-8 1998 Heparin and supersulfated glycosaminoglycans (GAGs) were able to bind to IFN-gamma, whereas N-desulfated N-acetylated GAGs with a low amount of sulfate were not. Heparin 0-7 interferon gamma Homo sapiens 73-82 9825824-8 1998 Heparin and supersulfated glycosaminoglycans (GAGs) were able to bind to IFN-gamma, whereas N-desulfated N-acetylated GAGs with a low amount of sulfate were not. Glycosaminoglycans 26-44 interferon gamma Homo sapiens 73-82 9825824-8 1998 Heparin and supersulfated glycosaminoglycans (GAGs) were able to bind to IFN-gamma, whereas N-desulfated N-acetylated GAGs with a low amount of sulfate were not. Glycosaminoglycans 46-50 interferon gamma Homo sapiens 73-82 9825824-8 1998 Heparin and supersulfated glycosaminoglycans (GAGs) were able to bind to IFN-gamma, whereas N-desulfated N-acetylated GAGs with a low amount of sulfate were not. Sulfates 17-24 interferon gamma Homo sapiens 73-82 9825824-9 1998 Inhibition of cell-bound heparan sulfate proteoglycan sulfation with NaClO3 resulted in an impaired MHC and ICAM-1 expression after IFN-gamma stimulation. Heparitin Sulfate 25-40 interferon gamma Homo sapiens 132-141 9825824-9 1998 Inhibition of cell-bound heparan sulfate proteoglycan sulfation with NaClO3 resulted in an impaired MHC and ICAM-1 expression after IFN-gamma stimulation. sodium chlorate 69-75 interferon gamma Homo sapiens 132-141 9825824-10 1998 CONCLUSION: We postulate that IFN-gamma binds to cell-bound heparan sulfate proteoglycan in a sulfation-dependent fashion. Heparitin Sulfate 60-75 interferon gamma Homo sapiens 30-39 9860237-6 1998 The regulatory interleukin-4/interferon-gamma (JL-4/IFN-gamma) balance showed a significant difference between atopic and nonatopic subjects after a short-term culture period (24 h) in the presence of the same concentration range of S-bioallethrin (P < 0.001). bioallethrin 233-247 interferon gamma Homo sapiens 29-45 9860237-6 1998 The regulatory interleukin-4/interferon-gamma (JL-4/IFN-gamma) balance showed a significant difference between atopic and nonatopic subjects after a short-term culture period (24 h) in the presence of the same concentration range of S-bioallethrin (P < 0.001). bioallethrin 233-247 interferon gamma Homo sapiens 52-61 9822289-4 1998 Priming of T cells from RA patients in the presence of recombinant (r)IL-2 plus rIL-12 induced a shift towards a TI pattern, characterized by increased production of interferon-gamma, that was more pronounced than in the case of healthy donors. ril-12 80-86 interferon gamma Homo sapiens 166-182 9884019-2 1998 Diverse kinds of stresses (ultraviolet, irradiation, heat shock and hypoxia) and biological factors (TNF-alpha, IFN-gamma and Fas antibody) require ceramide generation to execute apoptosis. Ceramides 148-156 interferon gamma Homo sapiens 112-121 9824405-5 1998 METHODS: The relationships among cord blood IgE concentrations, IFN-gamma and interleukin-2 (IL-2) productions by antigen-stimulated CBMCs, and the development of allergic disorders in 21 infants for 6 years were investigated. cbmcs 133-138 interferon gamma Homo sapiens 64-73 9824405-7 1998 The maximal IFN-gamma concentration in culture supernatants of ovalbumin (OA) or bovine serum albumin (BSA) stimulated CBMCs in infants who developed allergic disorders was significantly lower (P < 0.01) than that in infants who did not develop any allergic disorders. cbmcs 119-124 interferon gamma Homo sapiens 12-21 9824405-10 1998 CONCLUSION: Reduced IFN-gamma production by antigen-stimulated CBMCs is a risk factor of allergic disorders. cbmcs 63-68 interferon gamma Homo sapiens 20-29 9878122-0 1998 Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cyclic AMP 68-78 interferon gamma Homo sapiens 21-30 9787120-0 1998 Cocaine infusion increases interferon-gamma and decreases interleukin-10 in cocaine-dependent subjects. Cocaine 0-7 interferon gamma Homo sapiens 27-43 9787120-3 1998 Cocaine infusion, but not saline infusion, increased IFN-gamma secretion and decreased IL-10 secretion, while, in PBMC collected simultaneously from control subjects, secretion of these cytokines was unaltered. Cocaine 0-7 interferon gamma Homo sapiens 53-62 9787120-6 1998 In vitro cocaine treatment of PBMC from addicted subjects suppressed both IL-10 and IFN-gamma secretion. Cocaine 9-16 interferon gamma Homo sapiens 84-93 9878122-5 1998 Data demonstrated a significant inhibition of IL-17 as well as of IFN-gamma mRNA expression in CD8(+) T cells isolated from activated PBMC cultured in the presence of either dibutyryl cAMP (db-cAMP) or PGE2. Cyclic AMP 184-188 interferon gamma Homo sapiens 66-75 9878122-5 1998 Data demonstrated a significant inhibition of IL-17 as well as of IFN-gamma mRNA expression in CD8(+) T cells isolated from activated PBMC cultured in the presence of either dibutyryl cAMP (db-cAMP) or PGE2. Bucladesine 190-197 interferon gamma Homo sapiens 66-75 9878122-5 1998 Data demonstrated a significant inhibition of IL-17 as well as of IFN-gamma mRNA expression in CD8(+) T cells isolated from activated PBMC cultured in the presence of either dibutyryl cAMP (db-cAMP) or PGE2. Dinoprostone 202-206 interferon gamma Homo sapiens 66-75 9805229-8 1998 Exogenous IL-12 fully reconstituted proliferative reactivity and enhanced IFN-gamma production by both normal host and TBH lymphocytes in vitro. tbh 119-122 interferon gamma Homo sapiens 74-83 9930304-0 1998 Polyethylenimine-mediated transfection of human monocytes with the IFN-gamma gene: an approach for cancer adoptive immunotherapy. Polyethyleneimine 0-16 interferon gamma Homo sapiens 67-76 9858061-4 1998 THC decreased constitutive production of IL-8, MIP-1alpha, MIP-1beta, and RANTES and phorbol ester stimulated production of TNF-alpha, GM-CSF and IFN-gamma by NK cells. Dronabinol 0-3 interferon gamma Homo sapiens 146-155 9858061-4 1998 THC decreased constitutive production of IL-8, MIP-1alpha, MIP-1beta, and RANTES and phorbol ester stimulated production of TNF-alpha, GM-CSF and IFN-gamma by NK cells. Phorbol Esters 85-98 interferon gamma Homo sapiens 146-155 9794432-2 1998 IFN-gamma and TNF-alpha, alone or in combination, caused a significant up-regulation of the NADPH oxidase system as reflected by an enhancement of the PMA-stimulated superoxide release, cytochrome b558 content, and expression of gp91-phox and p47-phox genes on both days 2 and 7 of cell culture. Tetradecanoylphorbol Acetate 151-154 interferon gamma Homo sapiens 0-9 9794432-2 1998 IFN-gamma and TNF-alpha, alone or in combination, caused a significant up-regulation of the NADPH oxidase system as reflected by an enhancement of the PMA-stimulated superoxide release, cytochrome b558 content, and expression of gp91-phox and p47-phox genes on both days 2 and 7 of cell culture. Superoxides 166-176 interferon gamma Homo sapiens 0-9 9794432-6 1998 Indomethacin inhibited only the PMA-stimulated superoxide release of THP-1 cells differentiated with IFN-gamma and TNF-alpha during 7 days. Indomethacin 0-12 interferon gamma Homo sapiens 101-110 9794432-6 1998 Indomethacin inhibited only the PMA-stimulated superoxide release of THP-1 cells differentiated with IFN-gamma and TNF-alpha during 7 days. Tetradecanoylphorbol Acetate 32-35 interferon gamma Homo sapiens 101-110 9794432-6 1998 Indomethacin inhibited only the PMA-stimulated superoxide release of THP-1 cells differentiated with IFN-gamma and TNF-alpha during 7 days. Superoxides 47-57 interferon gamma Homo sapiens 101-110 9761115-1 1998 Concentrations of neopterin, which is produced by human monocytes/macrophages upon stimulation by interferon-gamma, were measured in urine specimens in 23 patients with squamous-cell carcinoma of the oral cavity at diagnosis and in 12 treated patients with the same disease when recurrence of the tumor was recognized. Neopterin 18-27 interferon gamma Homo sapiens 98-114 9848715-3 1998 We therefore analyzed the first intron of the IFN-gamma gene for a dinucleotide (CA) repeat polymorphism on chromosome 12q. Dinucleoside Phosphates 67-79 interferon gamma Homo sapiens 46-55 9763578-2 1998 In this study, we have examined the possibility to increase the sensitivity to Fas-induced apoptosis by pretreatment of MM cells with interferon-gamma (IFN-gamma) or interferon-alpha (IFN-alpha). ammonium ferrous sulfate 79-82 interferon gamma Homo sapiens 134-150 9788822-5 1998 BH4 levels were </=140-fold enhanced on treatment of HUVECs with combined interferon-gamma/tumor necrosis factor-alpha/interleukin-1 (IFN/TNF/IL-1). sapropterin 0-3 interferon gamma Homo sapiens 77-149 9763578-2 1998 In this study, we have examined the possibility to increase the sensitivity to Fas-induced apoptosis by pretreatment of MM cells with interferon-gamma (IFN-gamma) or interferon-alpha (IFN-alpha). ammonium ferrous sulfate 79-82 interferon gamma Homo sapiens 152-161 9763578-3 1998 Both IFN-gamma and IFN-alpha markedly increased the Fas-induced apoptosis in all cell lines tested (U-266-1970, U-266-1984, and U-1958). ammonium ferrous sulfate 52-55 interferon gamma Homo sapiens 5-14 9794205-13 1998 Expression of several proinflammatory cytokines including TNF-alpha, IL-6, IL-1beta, and IFN-gamma were also elevated in Av-exposed animals and modulated by dexamethasone. Dexamethasone 157-170 interferon gamma Homo sapiens 89-98 9892907-14 1998 Plasma levels of neopterin increased significantly during IFN-gamma treatment but not in the control group, whereas N-terminal procollagen III peptide levels did not change in either group. Neopterin 17-26 interferon gamma Homo sapiens 58-67 9744992-8 1998 Alendronate treatment of peripheral blood mononuclear cells also resulted in an increased production of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma). Alendronate 0-11 interferon gamma Homo sapiens 179-195 9744992-8 1998 Alendronate treatment of peripheral blood mononuclear cells also resulted in an increased production of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma). Alendronate 0-11 interferon gamma Homo sapiens 197-206 9769120-2 1998 Both IFNalpha and IFNgamma have been shown to exert their effects via a recently discovered signalling pathway by inducing tyrosine phosphorylation of their receptors. Tyrosine 123-131 interferon gamma Homo sapiens 18-26 9876351-8 1998 IL-1 alpha, TNF alpha and IFN gamma at concentrations of 10(5) U/l all inhibited TSH-induced NIS gene expression and iodide uptake. Thyrotropin 81-84 interferon gamma Homo sapiens 26-35 9876351-8 1998 IL-1 alpha, TNF alpha and IFN gamma at concentrations of 10(5) U/l all inhibited TSH-induced NIS gene expression and iodide uptake. Iodides 117-123 interferon gamma Homo sapiens 26-35 9811533-3 1998 The availability of glutamine significantly increased the production of interleukin (IL)-2 (2-fold), IL-10 (4-fold) and interferon (IFN)-gamma (4.5-fold) by Con A-stimulated PBMCs. Glutamine 20-29 interferon gamma Homo sapiens 120-142 9763540-4 1998 After stimulation with interleukin-1beta, tumor necrosis factor-alpha, interferon-gamma, and bacterial lipopolysaccharide, both venous and arterial SMC expressed COX-2 protein and released increased amounts of prostaglandins. Prostaglandins 210-224 interferon gamma Homo sapiens 71-87 9808170-0 1998 Vitamin D3: a transcriptional modulator of the interferon-gamma gene. Cholecalciferol 0-10 interferon gamma Homo sapiens 47-63 9808170-2 1998 Here, we analyze the effect of 1,25-(OH)2D3 on IFN-gamma gene transcription. Calcitriol 31-43 interferon gamma Homo sapiens 47-56 9740009-8 1998 Cu2+ and Hg2+ induced a decrease in IFN-gamma and IL-10 levels, and Hg2+ an increase in TNF-alpha concentrations. cupric ion 0-4 interferon gamma Homo sapiens 36-45 9759853-10 1998 Finally, dexamethasone induced TGF-beta secretion, but inhibited IFN-gamma and TNF-alphabeta. Dexamethasone 9-22 interferon gamma Homo sapiens 65-74 9731757-2 1998 Indoleamine 2,3-dioxygenase (IDO) and tryptophanyl-tRNA synthetase are enzymes of tryptophan metabolism whose expression in a variety of cells and tissues is highly inducible by interferon-gamma (IFN-gamma). Tryptophan 38-48 interferon gamma Homo sapiens 178-194 9731757-2 1998 Indoleamine 2,3-dioxygenase (IDO) and tryptophanyl-tRNA synthetase are enzymes of tryptophan metabolism whose expression in a variety of cells and tissues is highly inducible by interferon-gamma (IFN-gamma). Tryptophan 38-48 interferon gamma Homo sapiens 196-205 9731757-7 1998 In parallel with its effect on IDO mRNA expression, TGF-beta caused a marked reduction in intracellular IDO protein levels and abrogated IDO activity and tryptophan catabolism in these cells induced by IFN-gamma. Tryptophan 154-164 interferon gamma Homo sapiens 202-211 9759834-4 1998 However, during the peak of the acute CD4+ T cell response, >20% of the CD4+ T cells secreted IFN-gamma after stimulation with PMA and ionomycin, and >10% of the CD4+ T cells secreted IFN-gamma after stimulation with the LCMV peptides. Ionomycin 138-147 interferon gamma Homo sapiens 97-106 9809619-0 1998 The effect of calcium-related factors on the predominance of IFN-gamma or interleukin-4 in cultured mononuclear cells. Calcium 14-21 interferon gamma Homo sapiens 61-70 9809619-5 1998 Calcium-independent cytokine induction using anti-CD28 and PMA resulted in production of both cytokines, whereas depletion of extracellular calcium and magnesium adversely influenced the yield of both IL-4 and IFN-gamma. Calcium 0-7 interferon gamma Homo sapiens 210-219 9809619-5 1998 Calcium-independent cytokine induction using anti-CD28 and PMA resulted in production of both cytokines, whereas depletion of extracellular calcium and magnesium adversely influenced the yield of both IL-4 and IFN-gamma. Calcium 140-147 interferon gamma Homo sapiens 210-219 9809619-5 1998 Calcium-independent cytokine induction using anti-CD28 and PMA resulted in production of both cytokines, whereas depletion of extracellular calcium and magnesium adversely influenced the yield of both IL-4 and IFN-gamma. Magnesium 152-161 interferon gamma Homo sapiens 210-219 9809619-6 1998 Finally, calmidazolium, an inhibitor of calmodulin, had an enhancing effect on IFN-gamma yields when phytohemagglutinin (PHA) was the inducer and an adverse effect when A23187 was the inducer. calmidazolium 9-22 interferon gamma Homo sapiens 79-88 9743329-4 1998 Addition of PGE2 or DXM to human PBMCs stimulated with immobilized anti-CD3 plus IL-12 inhibited the production of IFN-gamma in a dose-responsive manner. Dinoprostone 12-16 interferon gamma Homo sapiens 115-124 9849654-1 1998 This study was undertaken to assess whether gamma-linolenic acid (GLA) in the form of evening primrose oil (EPO) could affect rat serum cytokines, interferon-gamma (IFN-gamma), monocyte chemotactic protein-1 (MCP-1) and tumour necrosis factor-alpha (TNF-alpha). gamma-Linolenic Acid 66-69 interferon gamma Homo sapiens 147-163 9849654-1 1998 This study was undertaken to assess whether gamma-linolenic acid (GLA) in the form of evening primrose oil (EPO) could affect rat serum cytokines, interferon-gamma (IFN-gamma), monocyte chemotactic protein-1 (MCP-1) and tumour necrosis factor-alpha (TNF-alpha). evening primrose oil 94-106 interferon gamma Homo sapiens 147-163 9849654-3 1998 In the presence of GLA, the IFN-gamma and MCP-1 levels were significantly decreased in contrast to the control group of TNF-alpha, which was significantly stimulated. gamma-Linolenic Acid 19-22 interferon gamma Homo sapiens 28-37 9849654-5 1998 The observations indicate that GLA may modulate the level of serum IFN-gamma, MCP-1 and TNF-alpha, which may be a worthwhile line of treatment in certain human diseases. gamma-Linolenic Acid 31-34 interferon gamma Homo sapiens 67-76 9743329-4 1998 Addition of PGE2 or DXM to human PBMCs stimulated with immobilized anti-CD3 plus IL-12 inhibited the production of IFN-gamma in a dose-responsive manner. Dexamethasone 20-23 interferon gamma Homo sapiens 115-124 9730868-5 1998 In contrast, C5a- and PMA-induced adhesion to TNF-alpha/IFN-gamma-activated NHBEC (increased from 11.1 +/- 1.3% to 21.9 +/- 1.0% and 27.6 +/- 1.9%, respectively) was CD18- and ICAM-1-dependent. Tetradecanoylphorbol Acetate 22-25 interferon gamma Homo sapiens 56-65 9756638-10 1998 In contrast, monocyte monolayers treated with IFN-gamma/TNF-alpha/calcitriol consisted of a syncitium of cells containing monocyte aggregates. Calcitriol 66-76 interferon gamma Homo sapiens 46-55 9734473-0 1998 Lysophosphatidylcholine enhances cytokine-induced interferon gamma expression in human T lymphocytes. Lysophosphatidylcholines 0-23 interferon gamma Homo sapiens 50-66 9734473-3 1998 In this study, we show that lyso-PC can also enhance interferon gamma (IFN-gamma) secretion and gene expression in human T lymphocytes. Lysophosphatidylcholines 28-35 interferon gamma Homo sapiens 53-80 9734473-4 1998 Lyso-PC-induced upregulation of IFN-gamma depended on the presence of IL-2, IL-12, or phytohemagglutinin in culture media and was similarly observed in both CD4+ and CD8+ subsets. We 201 0-7 interferon gamma Homo sapiens 32-41 9734473-5 1998 Actinomycin D chase by Northern blotting showed that lyso-PC significantly prolonged IFN-gamma mRNA half-lives in human T cells. Dactinomycin 0-13 interferon gamma Homo sapiens 85-94 9734473-5 1998 Actinomycin D chase by Northern blotting showed that lyso-PC significantly prolonged IFN-gamma mRNA half-lives in human T cells. Lysophosphatidylcholines 53-60 interferon gamma Homo sapiens 85-94 9730867-4 1998 Concanavalin A (Con A)-induced IFN-gamma, GM-CSF, and IL-3 mRNAs are dose-dependently inhibited by the nonselective betaAR agonist isoproterenol and by the selective beta2AR agonist fenoterol. Isoproterenol 131-144 interferon gamma Homo sapiens 31-40 9730867-4 1998 Concanavalin A (Con A)-induced IFN-gamma, GM-CSF, and IL-3 mRNAs are dose-dependently inhibited by the nonselective betaAR agonist isoproterenol and by the selective beta2AR agonist fenoterol. Fenoterol 182-191 interferon gamma Homo sapiens 31-40 9751101-5 1998 RESULTS: When ST cells were stimulated with PMA plus A23187 in bulk culture, IFNgamma-producing T cells were more frequently detected in the CD8+ subset, but cells producing other cytokines were found in the CD4+ subset. Calcimycin 53-59 interferon gamma Homo sapiens 77-85 9730867-6 1998 The observed inhibition on IFN-gamma, GM-CSF, and IL-3 mRNA was blocked by the selective beta2AR antagonist ICI 118,551 (10(-6) M) and by timolol (10(-6) M), a nonselective antagonist. Timolol 138-145 interferon gamma Homo sapiens 27-36 9751101-6 1998 Purified ST CD4+ T cells, after stimulation with PMA plus A23187, were able to produce higher levels of IFNgamma but lower levels of IL-4 and IL-13, by analysis at the single-cell level, as compared with the PB CD4+, CD45RO+ T cells. Calcimycin 58-64 interferon gamma Homo sapiens 104-112 9728563-4 1998 Interferon-gamma induced the activation of indoleamine 2,3-dioxygenase in MDM and inhibited the growth of GBS. gbs 106-109 interferon gamma Homo sapiens 0-16 9818793-3 1998 Here, we found that in vitro acute ethanol treatment (25-100 mM) results in a dose-dependent and significant increase of IL-12 in IFN-gamma (100 U/ml) plus Staphylococcal enterotoxin B (SEB; 1 microg/ml) stimulated monocytes and mononuclear cells but not in unstimulated cells from non-alcoholic blood donors. Ethanol 35-42 interferon gamma Homo sapiens 130-139 9818793-8 1998 Finally, elevation of intracellular cAMP levels by dbcAMP treatment consistently inhibited IL-12 as well as IL-10 production in monocytes induced by IFN-gamma or IFN-gamma plus 25 mM ethanol. Cyclic AMP 36-40 interferon gamma Homo sapiens 149-158 9818793-8 1998 Finally, elevation of intracellular cAMP levels by dbcAMP treatment consistently inhibited IL-12 as well as IL-10 production in monocytes induced by IFN-gamma or IFN-gamma plus 25 mM ethanol. Cyclic AMP 36-40 interferon gamma Homo sapiens 162-171 9818793-8 1998 Finally, elevation of intracellular cAMP levels by dbcAMP treatment consistently inhibited IL-12 as well as IL-10 production in monocytes induced by IFN-gamma or IFN-gamma plus 25 mM ethanol. Bucladesine 51-57 interferon gamma Homo sapiens 149-158 9818793-8 1998 Finally, elevation of intracellular cAMP levels by dbcAMP treatment consistently inhibited IL-12 as well as IL-10 production in monocytes induced by IFN-gamma or IFN-gamma plus 25 mM ethanol. Bucladesine 51-57 interferon gamma Homo sapiens 162-171 9725242-0 1998 Novel regulation of cyclooxygenase-2 expression and prostaglandin E2 production by IFN-gamma in human macrophages. Dinoprostone 52-68 interferon gamma Homo sapiens 83-92 9725242-5 1998 Interestingly, IFN-gamma-primed cells showed 40 to 60% lower levels of COX-2 mRNA, protein expression, and PGE2 production as compared with nonprimed cells. Dinoprostone 107-111 interferon gamma Homo sapiens 15-24 9725242-9 1998 The down-regulatory effect of IFN-gamma on IL-1beta-induced COX-2 expression was abrogated with cycloheximide. Cycloheximide 96-109 interferon gamma Homo sapiens 30-39 9891902-9 1998 Tretinoin very potently stimulated IL-5 release, and inhibited IFN gamma release by SEB-stimulated human PBMCs. Tretinoin 0-9 interferon gamma Homo sapiens 63-72 9821108-3 1998 Combined treatment with IL-1 beta and IFN-gamma caused greater inhibition of TGF-beta secretion compared to treatment with IFN-gamma, and almost the same levels of inhibition as treatment with vincristine and etoposide. Vincristine 193-204 interferon gamma Homo sapiens 38-47 9821108-3 1998 Combined treatment with IL-1 beta and IFN-gamma caused greater inhibition of TGF-beta secretion compared to treatment with IFN-gamma, and almost the same levels of inhibition as treatment with vincristine and etoposide. Etoposide 209-218 interferon gamma Homo sapiens 38-47 9863413-9 1998 In patients with atopic dermatitis, prostaglandin E has suppressive effects on Interferon gamma production by Th1 helper cells and increases production of Interleukin 4 by the Th2 cells. Prostaglandins E 36-51 interferon gamma Homo sapiens 79-95 9726838-0 1998 Increased levels of IFN-gamma in the trigeminal ganglion correlate with protection against HSV-1-induced encephalitis following subcutaneous administration with androstenediol. Androstenediol 161-175 interferon gamma Homo sapiens 20-29 9726842-6 1998 We found that the IFNgamma or the IFNgamma/TNF alpha induced activation of indoleamine 2,3-dioxygenase is responsible for the inhibition of streptococcal growth, since the addition of supplemental L-tryptophan completely blocks the IFNgamma induced bacteriostasis. indolamine 75-86 interferon gamma Homo sapiens 18-26 9726842-6 1998 We found that the IFNgamma or the IFNgamma/TNF alpha induced activation of indoleamine 2,3-dioxygenase is responsible for the inhibition of streptococcal growth, since the addition of supplemental L-tryptophan completely blocks the IFNgamma induced bacteriostasis. indolamine 75-86 interferon gamma Homo sapiens 34-42 9726842-6 1998 We found that the IFNgamma or the IFNgamma/TNF alpha induced activation of indoleamine 2,3-dioxygenase is responsible for the inhibition of streptococcal growth, since the addition of supplemental L-tryptophan completely blocks the IFNgamma induced bacteriostasis. indolamine 75-86 interferon gamma Homo sapiens 34-42 9726842-6 1998 We found that the IFNgamma or the IFNgamma/TNF alpha induced activation of indoleamine 2,3-dioxygenase is responsible for the inhibition of streptococcal growth, since the addition of supplemental L-tryptophan completely blocks the IFNgamma induced bacteriostasis. Tryptophan 197-209 interferon gamma Homo sapiens 18-26 9726842-6 1998 We found that the IFNgamma or the IFNgamma/TNF alpha induced activation of indoleamine 2,3-dioxygenase is responsible for the inhibition of streptococcal growth, since the addition of supplemental L-tryptophan completely blocks the IFNgamma induced bacteriostasis. Tryptophan 197-209 interferon gamma Homo sapiens 34-42 9726842-6 1998 We found that the IFNgamma or the IFNgamma/TNF alpha induced activation of indoleamine 2,3-dioxygenase is responsible for the inhibition of streptococcal growth, since the addition of supplemental L-tryptophan completely blocks the IFNgamma induced bacteriostasis. Tryptophan 197-209 interferon gamma Homo sapiens 34-42 9738953-2 1998 We found that lyso-PC increased IFN-gamma production and CD40L expression in CD4+ T cells stimulated with anti-CD3 Ab and recombinant CD80 molecules, whereas lyso-PC did not affect IL-2 and IL-4 production. Lysophosphatidylcholines 14-21 interferon gamma Homo sapiens 32-41 9698230-1 1998 A chromatographic method was developed for quantitative analysis of site-specific microheterogeneity of the two N-linked glycosylation sites in recombinant human interferon-gamma produced from Chinese hamster ovary (CHO) cell culture. Nitrogen 112-113 interferon gamma Homo sapiens 162-178 9724006-4 1998 In parallel, ELISPOT assay to detect MBP- and PHA-reactive IFN-gamma secreting blood MNC+/-Linomide was used. roquinimex 91-99 interferon gamma Homo sapiens 59-68 9722223-8 1998 Inhibition of IFN-gamma by A802715 was three times as potent, and by POF two times. A 802715 27-34 interferon gamma Homo sapiens 14-23 9727639-2 1998 There was a significant, transient increase in interleukin-12 and interferon-gamma (IFNgamma) levels in whole blood samples collected 4 hr after alcohol consumption in response to an ex vivo bacterial challenge with lipopolysaccharide (p < 0.02). Alcohols 145-152 interferon gamma Homo sapiens 66-82 9727639-2 1998 There was a significant, transient increase in interleukin-12 and interferon-gamma (IFNgamma) levels in whole blood samples collected 4 hr after alcohol consumption in response to an ex vivo bacterial challenge with lipopolysaccharide (p < 0.02). Alcohols 145-152 interferon gamma Homo sapiens 84-92 9727639-3 1998 However, decreased IFNgamma levels were produced by mononuclear cells collected later after alcohol consumption (16 hr), suggesting that acute alcohol consumption has a biphasic effect on IFNgamma inducibility. Alcohols 92-99 interferon gamma Homo sapiens 19-27 9727639-3 1998 However, decreased IFNgamma levels were produced by mononuclear cells collected later after alcohol consumption (16 hr), suggesting that acute alcohol consumption has a biphasic effect on IFNgamma inducibility. Alcohols 143-150 interferon gamma Homo sapiens 19-27 9727639-3 1998 However, decreased IFNgamma levels were produced by mononuclear cells collected later after alcohol consumption (16 hr), suggesting that acute alcohol consumption has a biphasic effect on IFNgamma inducibility. Alcohols 143-150 interferon gamma Homo sapiens 188-196 9744563-2 1998 Recently, we found that priming microglia with interferon (IFN)-gamma or tumor necrosis factor (TNF)-alpha resulted in an enhanced production of superoxide anion, a reactive oxygen intermediate that may be pathogenic during brain inflammation. Superoxides 145-161 interferon gamma Homo sapiens 47-69 9710434-6 1998 Patients followed prospectively before and after starting CY/MP treatment showed a gradual decrease in IL-12 and IFN-gamma production and an increase in IL-4 and IL-5. Cysteine 58-60 interferon gamma Homo sapiens 113-122 9710434-6 1998 Patients followed prospectively before and after starting CY/MP treatment showed a gradual decrease in IL-12 and IFN-gamma production and an increase in IL-4 and IL-5. 6-trimethylsilylthio-9-trimethylsilylpurine 61-63 interferon gamma Homo sapiens 113-122 9744563-2 1998 Recently, we found that priming microglia with interferon (IFN)-gamma or tumor necrosis factor (TNF)-alpha resulted in an enhanced production of superoxide anion, a reactive oxygen intermediate that may be pathogenic during brain inflammation. Oxygen 174-180 interferon gamma Homo sapiens 47-69 9744563-5 1998 Maximal inhibition of microglial cell superoxide generation by U50,488 was observed at 10 nM for the priming effect of interferon-gamma and at 1 microM for tumor necrosis factor-alpha. Superoxides 38-48 interferon gamma Homo sapiens 119-135 9716178-3 1998 In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants. Nitrates 210-217 interferon gamma Homo sapiens 66-75 9865496-8 1998 Collectively, our data indicate that NO2- + NO3- levels correlate with IFN levels and immunoreactivity, and overall suggest that IFN-gamma and nitric oxide production together play a role in the host defense mechanisms in human hydatidosis. Nitrogen Dioxide 37-40 interferon gamma Homo sapiens 129-138 9619301-4 1998 We present here the first direct evidence that noradrenaline elicits long-lasting NO production in C6 cells pretreated with lipopolysaccharide and interferon-gamma, an effect blocked by NG-monomethyl-L-arginine, a NO synthase inhibitor. Norepinephrine 47-60 interferon gamma Homo sapiens 147-163 9619301-4 1998 We present here the first direct evidence that noradrenaline elicits long-lasting NO production in C6 cells pretreated with lipopolysaccharide and interferon-gamma, an effect blocked by NG-monomethyl-L-arginine, a NO synthase inhibitor. omega-N-Methylarginine 186-210 interferon gamma Homo sapiens 147-163 9756187-4 1998 The production and release of pro-inflammatory cytokines are affected by theophylline showing a potent inhibitory effect on the production of IL-1beta, TNF-alpha and IFN-gamma. Theophylline 73-85 interferon gamma Homo sapiens 166-175 9756205-8 1998 In contrast, although interferon-gamma-mediated eosinophil viability was inhibited by 1.0-1000 nM fluticasone 17-propionate, this inhibition was not overcome by increased concentrations of interferon-gamma. Fluticasone 98-123 interferon gamma Homo sapiens 22-38 9710208-6 1998 After paraformaldehyde fixation of both quiescent or IFN-gamma/TNF-alpha-preactivated monocytes, cAMP production was no longer detectable, suggesting monocytes as the cell of origin for the increased cAMP synthesis. paraform 6-22 interferon gamma Homo sapiens 53-62 9722933-8 1998 Neutralization of IFN-gamma in stimulated LCM also partially inhibited the increase in alkaline phosphatase production but had no effects on the decrease in osteocalcin production. Lincomycin 42-45 interferon gamma Homo sapiens 18-27 9722937-5 1998 Higher ribavirin concentrations markedly inhibited IFN-gamma production, but augmented interleukins (IL) 2, 4, and 12 secretion. Ribavirin 7-16 interferon gamma Homo sapiens 51-60 9722937-7 1998 Thus, ribavirin and IFN-alpha appear to cause diverse effects on immunoregulatory cytokine secretion, and when combined, counteracted for production of IL-2 and IL-12, while upregulated mononuclear cell secretion of IFN-gamma and that of the anti-inflammatory cytokine IL-10. Ribavirin 6-15 interferon gamma Homo sapiens 216-225 9710231-5 1998 IFN-gamma-induced CD40 mRNA expression is partially sensitive to the protein synthesis inhibitor puromycin, suggesting that ongoing protein synthesis is necessary for optimal induction of CD40 mRNA by IFN-gamma. Puromycin 97-106 interferon gamma Homo sapiens 0-9 9710231-5 1998 IFN-gamma-induced CD40 mRNA expression is partially sensitive to the protein synthesis inhibitor puromycin, suggesting that ongoing protein synthesis is necessary for optimal induction of CD40 mRNA by IFN-gamma. Puromycin 97-106 interferon gamma Homo sapiens 201-210 9710208-6 1998 After paraformaldehyde fixation of both quiescent or IFN-gamma/TNF-alpha-preactivated monocytes, cAMP production was no longer detectable, suggesting monocytes as the cell of origin for the increased cAMP synthesis. Cyclic AMP 97-101 interferon gamma Homo sapiens 53-62 9710208-6 1998 After paraformaldehyde fixation of both quiescent or IFN-gamma/TNF-alpha-preactivated monocytes, cAMP production was no longer detectable, suggesting monocytes as the cell of origin for the increased cAMP synthesis. Cyclic AMP 200-204 interferon gamma Homo sapiens 53-62 9688322-0 1998 IFN-gamma inhibits AP-1 binding activity in human brain-derived cells through a nitric oxide dependent mechanism. Nitric Oxide 80-92 interferon gamma Homo sapiens 0-9 9761378-3 1998 Pentoxifyllin (Ptx) regulates the production of several cytokines including tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1) and, interferon gamma (IFN-gamma). Pentoxifylline 0-13 interferon gamma Homo sapiens 143-170 9761378-3 1998 Pentoxifyllin (Ptx) regulates the production of several cytokines including tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1) and, interferon gamma (IFN-gamma). Pentoxifylline 15-18 interferon gamma Homo sapiens 143-170 9761378-4 1998 We wished in this study to determine whether Ptx modified the spontaneous and cytokine-induced GAG synthesis by REF and IFN-gamma induced HLA-DR expression. Pentoxifylline 45-48 interferon gamma Homo sapiens 120-129 9688322-6 1998 Together, these results suggest that IFN-gamma can inhibit AP-1 binding activity through a nitric oxide dependent mechanism. Nitric Oxide 91-103 interferon gamma Homo sapiens 37-46 9703187-2 1998 Along with prompt and clear cut clinical improvement, treatment with Fucidin was associated with a rapid decline in the blood concentrations of inflammatory cytokines presumably implicated in the pathogenesis of Guillain-Barre syndrome such as interleukin-2, interferon-gamma, and tumor necrosis factor-alpha. Fusidic Acid 69-76 interferon gamma Homo sapiens 259-308 9691088-3 1998 Treatment of human islets with a combination of tumor necrosis factor (TNF) + lipopolysaccharide (LPS) + interferon-gamma (IFN-gamma) stimulates inducible nitric oxide synthase (iNOS) expression, nitric oxide production, and inhibits glucose-stimulated insulin secretion. Nitric Oxide 155-167 interferon gamma Homo sapiens 105-121 9691088-3 1998 Treatment of human islets with a combination of tumor necrosis factor (TNF) + lipopolysaccharide (LPS) + interferon-gamma (IFN-gamma) stimulates inducible nitric oxide synthase (iNOS) expression, nitric oxide production, and inhibits glucose-stimulated insulin secretion. Nitric Oxide 155-167 interferon gamma Homo sapiens 123-132 9691088-3 1998 Treatment of human islets with a combination of tumor necrosis factor (TNF) + lipopolysaccharide (LPS) + interferon-gamma (IFN-gamma) stimulates inducible nitric oxide synthase (iNOS) expression, nitric oxide production, and inhibits glucose-stimulated insulin secretion. Glucose 234-241 interferon gamma Homo sapiens 105-121 9691088-3 1998 Treatment of human islets with a combination of tumor necrosis factor (TNF) + lipopolysaccharide (LPS) + interferon-gamma (IFN-gamma) stimulates inducible nitric oxide synthase (iNOS) expression, nitric oxide production, and inhibits glucose-stimulated insulin secretion. Glucose 234-241 interferon gamma Homo sapiens 123-132 9691088-4 1998 The IL-1 receptor antagonist protein (IRAP) prevents TNF + LPS + IFN-gamma-induced iNOS expression and nitrite production, and attenuates the inhibitory effects on glucose-stimulated insulin secretion by human islets. Nitrites 103-110 interferon gamma Homo sapiens 65-74 9691088-5 1998 Inhibition of iNOS activity by aminoguanidine also attenuates TNF + LPS + IFN-gamma-induced inhibition of insulin secretion by human islets. pimagedine 31-45 interferon gamma Homo sapiens 74-83 9691088-6 1998 These results indicate that the inhibitory effects of TNF + LPS + IFN-gamma are mediated by nitric oxide, produced by the actions of IL-1 released endogenously within human islets. Nitric Oxide 92-104 interferon gamma Homo sapiens 66-75 9668040-3 1998 Serine phosphorylation of Stat1alpha is required for maximal transcriptional activation of early response genes by interferon gamma (IFNgamma) as well as the antiviral and antigrowth actions of this cytokine. Serine 0-6 interferon gamma Homo sapiens 115-142 10192430-6 1999 INF increased IGFBP4 mRNA and protein levels at 12 h, with a decline to baseline by 24 h. In contrast, IGFBP4 was not regulated in response to IL-6, TNF-alpha, PDGF BB, bFGF, TGF-beta or the cAMP agonist, forskolin. Cyclic AMP 191-195 interferon gamma Homo sapiens 0-3 9714533-1 1998 A co-culture system was used to study the effect of reactive nitrogen species (RNS) generated by RAW 264.7 macrophages grown on filters and activated by lipopolysaccharide and interferon-gamma, on the alpha-tocopherol levels in ECV 302 endothelial cells. Reactive Nitrogen Species 52-77 interferon gamma Homo sapiens 176-192 10192430-6 1999 INF increased IGFBP4 mRNA and protein levels at 12 h, with a decline to baseline by 24 h. In contrast, IGFBP4 was not regulated in response to IL-6, TNF-alpha, PDGF BB, bFGF, TGF-beta or the cAMP agonist, forskolin. Colforsin 205-214 interferon gamma Homo sapiens 0-3 9714533-1 1998 A co-culture system was used to study the effect of reactive nitrogen species (RNS) generated by RAW 264.7 macrophages grown on filters and activated by lipopolysaccharide and interferon-gamma, on the alpha-tocopherol levels in ECV 302 endothelial cells. Reactive Nitrogen Species 79-82 interferon gamma Homo sapiens 176-192 9714533-1 1998 A co-culture system was used to study the effect of reactive nitrogen species (RNS) generated by RAW 264.7 macrophages grown on filters and activated by lipopolysaccharide and interferon-gamma, on the alpha-tocopherol levels in ECV 302 endothelial cells. alpha-Tocopherol 201-217 interferon gamma Homo sapiens 176-192 9682002-6 1998 Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression. Dexamethasone 39-52 interferon gamma Homo sapiens 203-212 9682002-6 1998 Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression. Dexamethasone 143-156 interferon gamma Homo sapiens 203-212 9682002-6 1998 Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression. Tetradecanoylphorbol Acetate 172-175 interferon gamma Homo sapiens 203-212 9682002-6 1998 Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression. Ionomycin 176-185 interferon gamma Homo sapiens 203-212 9703247-3 1998 The addition of 10 U/ml IFN-gamma, together with more than 1 ng/ml LPS to JA-4 cells, increased .NO production remarkably, while IFN-gamma did not reverse the defect of .NO production in LPS1916 cells when they were treated with less than 10 ng/ml LPS; however, it induced .NO production by the mutant cells with more than 100 ng/ml LPS. lps1916 187-194 interferon gamma Homo sapiens 24-33 9670962-3 1998 HeLa and CV-1 cells treated only with L-thyroxine (T4) demonstrated increased tyrosine phosphorylation and nuclear translocation (= activation) of STAT1alpha; this hormone effect on signal transduction, and T4 potentiation of IFN-gamma-induced HLA-DR expression, were blocked by the inhibitors CGP 41251 (PKC) and genistein (tyrosine kinase). Thyroxine 38-49 interferon gamma Homo sapiens 226-235 9670962-7 1998 T4 increased IFN-gamma-induced HLA-DR protein 2.2-fold and HLA-DR mRNA fourfold after 2 d. Treatment with actinomycin D after induction of HLA-DR mRNA with IFN-gamma, with or without T4, showed that thyroid hormone decreased the t(1/2) of mRNA from 2.4 to 1.1 h. HeLa and CV-1 cells lack functional nuclear thyroid hormone receptor. Dactinomycin 106-119 interferon gamma Homo sapiens 13-22 9670962-7 1998 T4 increased IFN-gamma-induced HLA-DR protein 2.2-fold and HLA-DR mRNA fourfold after 2 d. Treatment with actinomycin D after induction of HLA-DR mRNA with IFN-gamma, with or without T4, showed that thyroid hormone decreased the t(1/2) of mRNA from 2.4 to 1.1 h. HeLa and CV-1 cells lack functional nuclear thyroid hormone receptor. Dactinomycin 106-119 interferon gamma Homo sapiens 156-165 9670962-8 1998 Tetraiodothyroacetic acid (tetrac) and 3,5,3"-triiodo-thyroacetic acid (triac) blocked T4 potentiation of IFN-gamma-induced HLA-DR expression and T4 activation of STAT1alpha. tetraiodothyroacetic acid 0-25 interferon gamma Homo sapiens 106-115 9670962-8 1998 Tetraiodothyroacetic acid (tetrac) and 3,5,3"-triiodo-thyroacetic acid (triac) blocked T4 potentiation of IFN-gamma-induced HLA-DR expression and T4 activation of STAT1alpha. tetraiodothyroacetic acid 27-33 interferon gamma Homo sapiens 106-115 9670962-8 1998 Tetraiodothyroacetic acid (tetrac) and 3,5,3"-triiodo-thyroacetic acid (triac) blocked T4 potentiation of IFN-gamma-induced HLA-DR expression and T4 activation of STAT1alpha. 3,3',5-triiodothyroacetic acid 39-70 interferon gamma Homo sapiens 106-115 9670962-8 1998 Tetraiodothyroacetic acid (tetrac) and 3,5,3"-triiodo-thyroacetic acid (triac) blocked T4 potentiation of IFN-gamma-induced HLA-DR expression and T4 activation of STAT1alpha. 3,3',5-triiodothyroacetic acid 72-77 interferon gamma Homo sapiens 106-115 9665110-2 1998 In an attempt to determine the mechanism of beta-carotene"s effect, we analyzed the production of NK cell-enhancing cytokines (interferon alpha, interferon gamma, and interleukin 12). beta Carotene 44-57 interferon gamma Homo sapiens 127-181 9667590-2 1998 In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive effect of IFN-beta1b and the phosphodiesterase inhibitor pentoxifylline (PTX) on proliferation and the production of tumor necrosis factor-alpha (TNF-alpha), lymphotoxin (LT), and interferon-gamma (IFN-gamma). Pentoxifylline 163-177 interferon gamma Homo sapiens 286-302 9667590-2 1998 In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive effect of IFN-beta1b and the phosphodiesterase inhibitor pentoxifylline (PTX) on proliferation and the production of tumor necrosis factor-alpha (TNF-alpha), lymphotoxin (LT), and interferon-gamma (IFN-gamma). Pentoxifylline 163-177 interferon gamma Homo sapiens 304-313 9667590-2 1998 In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive effect of IFN-beta1b and the phosphodiesterase inhibitor pentoxifylline (PTX) on proliferation and the production of tumor necrosis factor-alpha (TNF-alpha), lymphotoxin (LT), and interferon-gamma (IFN-gamma). Pentoxifylline 179-182 interferon gamma Homo sapiens 286-302 9667590-2 1998 In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive effect of IFN-beta1b and the phosphodiesterase inhibitor pentoxifylline (PTX) on proliferation and the production of tumor necrosis factor-alpha (TNF-alpha), lymphotoxin (LT), and interferon-gamma (IFN-gamma). Pentoxifylline 179-182 interferon gamma Homo sapiens 304-313 9692873-9 1998 From these data, we conclude that IFN-gamma and TNF-alpha can up-regulate cell surface expression of CD95 on eosinophils, which leads to an increased susceptibility of eosinophils to Fas-mediated apoptosis. ammonium ferrous sulfate 183-186 interferon gamma Homo sapiens 34-43 9797646-1 1998 Excessive interferon-gamma (IFN-gamma) production appears to be a primary immunological lesion in vitamin A-deficient experimental animals but comparable data from humans is lacking. Vitamin A 98-107 interferon gamma Homo sapiens 10-26 9797646-1 1998 Excessive interferon-gamma (IFN-gamma) production appears to be a primary immunological lesion in vitamin A-deficient experimental animals but comparable data from humans is lacking. Vitamin A 98-107 interferon gamma Homo sapiens 28-37 9797646-2 1998 We investigated IFN-gamma production in South African children by measurement of urinary excretion of neopterin, a product of IFN-gamma-activated monocytes or macrophages. Neopterin 102-111 interferon gamma Homo sapiens 16-25 9797646-2 1998 We investigated IFN-gamma production in South African children by measurement of urinary excretion of neopterin, a product of IFN-gamma-activated monocytes or macrophages. Neopterin 102-111 interferon gamma Homo sapiens 126-135 9704165-1 1998 inhibitor rolipram in vitro reduces the numbers of MBP-reactive IFN-gamma and TNF-alpha mRNA expressing blood mononuclear cells in patients with multiple sclerosis. Rolipram 10-18 interferon gamma Homo sapiens 64-73 9704165-9 1998 Rolipram reduced the numbers of MBP-reactive IFN-gamma- and TNF-alpha mRNA-expressing blood MNC in MS, and numbers of AChR-reactive IFN-gamma-, TNF-alpha-, and LT mRNA-positive cells in MG. Rolipram 0-8 interferon gamma Homo sapiens 45-54 9649436-9 1998 Thus, serine and tyrosine phosphorylation of Stat1 are caused independently of each other, but the serine kinase may recognize tyrosine-phosphorylated Stat1 preferentially in the course of an IFN-gamma response. Tyrosine 127-135 interferon gamma Homo sapiens 192-201 9795834-8 1998 We have shown here that there is a small but consistent induction of some cytokines (TNF-alpha, IFN-gamma and IL-2) when human blood is directly exposed to O3 concentrations up to 100 micrograms/ml per g of blood. Ozone 156-158 interferon gamma Homo sapiens 96-105 9726030-10 1998 TNF, possibly via induction of IL-6, and IFN-gamma induce hypoferraemia, which may in part result from a decrease in tissue iron release based on a primary stimulation of ferritin synthesis. Iron 124-128 interferon gamma Homo sapiens 41-50 9828925-11 1998 Moreover, when co-cultured with IFN-gamma, these macrophages produced a large amount of nitric oxide as compared to non-Tgm cells cultured in the same condition as Tgm cells. Nitric Oxide 88-100 interferon gamma Homo sapiens 32-41 9776474-9 1998 In contrast, dexamethasone inhibited markedly the expression of all cytokines tested (IL-2, IL-4, IL-6, IL-10, IFN-gamma and TNF-alpha) in dose-dependent fashion, reducing levels to near to background. Dexamethasone 13-26 interferon gamma Homo sapiens 111-120 9647259-4 1998 PBL were cultured with brefeldin A without mitogen and IL-2 for 14 h. Under these conditions, CD8+ cells produced proinflammatory cytokines including IFN-gamma, TNF-alpha, and IL-2, which were significantly elevated in HAM/TSP patients. Brefeldin A 23-34 interferon gamma Homo sapiens 150-159 9712367-0 1998 Expression and regulation of interferon-gamma-induced tryptophan catabolism in cultured skin fibroblasts. Tryptophan 54-64 interferon gamma Homo sapiens 29-45 9712367-1 1998 Interferon-gamma (IFN-gamma)-induced, indoleamine dioxygenase-catalyzed tryptophan catabolism was studied in cultured human foreskin fibroblasts using the increase in cellular kynurenine synthesis as an index of gene expression. Tryptophan 72-82 interferon gamma Homo sapiens 0-27 9712367-1 1998 Interferon-gamma (IFN-gamma)-induced, indoleamine dioxygenase-catalyzed tryptophan catabolism was studied in cultured human foreskin fibroblasts using the increase in cellular kynurenine synthesis as an index of gene expression. Kynurenine 176-186 interferon gamma Homo sapiens 0-27 9712367-2 1998 The time courses of the inhibition of IFN-gamma-induced kynurenine synthesis by actinomycin D and cycloheximide showed that the indoleamine dioxygenase gene was transcribed as early as 2 h and translated as early as 5 h after initiation of IFN treatment. Kynurenine 56-66 interferon gamma Homo sapiens 38-47 9712367-2 1998 The time courses of the inhibition of IFN-gamma-induced kynurenine synthesis by actinomycin D and cycloheximide showed that the indoleamine dioxygenase gene was transcribed as early as 2 h and translated as early as 5 h after initiation of IFN treatment. Dactinomycin 80-93 interferon gamma Homo sapiens 38-47 9712367-2 1998 The time courses of the inhibition of IFN-gamma-induced kynurenine synthesis by actinomycin D and cycloheximide showed that the indoleamine dioxygenase gene was transcribed as early as 2 h and translated as early as 5 h after initiation of IFN treatment. Cycloheximide 98-111 interferon gamma Homo sapiens 38-47 9712367-9 1998 These results indicate that the expression of kynurenine synthesis is modulated at the transcriptional and posttranscriptional levels by protein tyrosine kinase and by a Ser/Thr kinase with properties distinctly different from those of conventional protein kinase C. The capacity for attenuation of this IFN-gamma-induced response over its entire time course by many effectors and through multiple cellular signaling pathways may represent a mechanism for fine-tuning the level of oxidative tryptophan metabolism to meet the needs of a particular cytostatic or antiproliferative response. Kynurenine 46-56 interferon gamma Homo sapiens 304-313 9649586-0 1998 Vitamin A is required for regulation of polymeric immunoglobulin receptor (pIgR) expression by interleukin-4 and interferon-gamma in a human intestinal epithelial cell line. Vitamin A 0-9 interferon gamma Homo sapiens 113-129 9649586-2 1998 We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. Vitamin A 39-48 interferon gamma Homo sapiens 181-197 9649586-2 1998 We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. Vitamin A 39-48 interferon gamma Homo sapiens 199-208 9649586-2 1998 We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. Tretinoin 70-83 interferon gamma Homo sapiens 181-197 9649586-2 1998 We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. Tretinoin 70-83 interferon gamma Homo sapiens 199-208 9649586-2 1998 We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. Tretinoin 85-87 interferon gamma Homo sapiens 181-197 9649586-2 1998 We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. Tretinoin 85-87 interferon gamma Homo sapiens 199-208 10200499-5 1998 Sodium butyrate also induces tumor cell sensitization to the apoptotic effect of the combination of TNF-alpha and IFN-gamma, but it does not modify the level of the FADD/Mort1 adaptator molecule, at the connection between Fas- and TNF-dependent apoptosis pathways. Butyric Acid 0-15 interferon gamma Homo sapiens 114-123 9649578-5 1998 Acetylcholine release was increased by viral infection and by treatment with IFN-gamma (300 U/ml). Acetylcholine 0-13 interferon gamma Homo sapiens 77-86 9705247-3 1998 We have previously demonstrated that tanapox virus (TPV) infected cells secrete an early 38 kDa glycopeptide that binds to human (h) interferon-gamma, hIL-2, and hIL-5. Glycopeptides 96-108 interferon gamma Homo sapiens 133-149 9616137-2 1998 We demonstrate here that interferon-gamma (IFN-gamma) increases the expression of chemokine receptors CCR1, CCR3, and CCR5 in monocytoid U937 cells as detected by cell surface molecule labeling and mRNA expression, as well as by intracellular calcium mobilization and cell migration in response to specific ligands. Calcium 243-250 interferon gamma Homo sapiens 25-41 9616137-2 1998 We demonstrate here that interferon-gamma (IFN-gamma) increases the expression of chemokine receptors CCR1, CCR3, and CCR5 in monocytoid U937 cells as detected by cell surface molecule labeling and mRNA expression, as well as by intracellular calcium mobilization and cell migration in response to specific ligands. Calcium 243-250 interferon gamma Homo sapiens 43-52 9650577-3 1998 Treatment of the cells with the A2A receptor agonist CGS 21680 inhibited both NO production and iNOS expression induced by stimulation with either LPS/IFN-gamma or TNF-alpha/IL-1beta, whereas the A1 and A3 receptor agonists, CPA and Cl-IB-MECA, respectively, did not have significant inhibitory effects. cysteinylglycine 53-56 interferon gamma Homo sapiens 151-160 9747450-9 1998 Only interferon-gamma incubated alone was capable of increasing nitrite levels. Nitrites 64-71 interferon gamma Homo sapiens 5-21 9652304-3 1998 In contrast, chronic exposure of mice to trimellitic anhydride (TMA), a respiratory allergen associated in humans with occupational asthma, induced instead the production by LNC of relatively high concentrations of IL-4 and IL-10, but little IFN-gamma. trimellitic anhydride 64-67 interferon gamma Homo sapiens 242-251 9660044-14 1998 After fenofibrate therapy, IFN-gamma levels decreased to 24.8 +/- 2.9 pg/ml (p < 0.01). Fenofibrate 6-17 interferon gamma Homo sapiens 27-36 9660044-15 1998 The decreased levels of TC, TG, and LDL correlated with the decreased levels of TNF-alpha and IFN-gamma. Technetium 24-26 interferon gamma Homo sapiens 94-103 9660044-15 1998 The decreased levels of TC, TG, and LDL correlated with the decreased levels of TNF-alpha and IFN-gamma. Triglycerides 28-30 interferon gamma Homo sapiens 94-103 9754910-3 1998 Analysis of specific [3H]-bradykinin binding revealed that IFNgamma-treated cells had a two- to threefold increase in bradykinin receptor number compared to the controls with no effect on receptor affinity. Tritium 22-24 interferon gamma Homo sapiens 59-67 9592200-7 1998 A-498 cells achieved a decreased sensitivity to dFdC and VBL after pre-exposure to IFN-gamma. gemcitabine 48-52 interferon gamma Homo sapiens 83-92 9648713-10 1998 In vitro, PA-HSA stimulation did not affect subset ratios but led to release of small amounts of IL-5 and IFN-gamma, with no detectable increase in IL-4. pa-hsa 10-16 interferon gamma Homo sapiens 106-115 9641464-0 1998 Antagonism of LPS and IFN-gamma induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric oxide inhibition of adenylate cyclase. Morphine 89-97 interferon gamma Homo sapiens 22-31 9641464-0 1998 Antagonism of LPS and IFN-gamma induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric oxide inhibition of adenylate cyclase. anandamide 102-112 interferon gamma Homo sapiens 22-31 9641464-0 1998 Antagonism of LPS and IFN-gamma induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric oxide inhibition of adenylate cyclase. nitric 116-122 interferon gamma Homo sapiens 22-31 9687151-2 1998 We have shown previously that IFNgamma inhibited thyroglobulin (Tg) gene transcription, and that its action was mediated by an increase in intracellular calcium and inositol phosphates. Calcium 153-160 interferon gamma Homo sapiens 30-38 9687151-2 1998 We have shown previously that IFNgamma inhibited thyroglobulin (Tg) gene transcription, and that its action was mediated by an increase in intracellular calcium and inositol phosphates. Inositol Phosphates 165-184 interferon gamma Homo sapiens 30-38 9687151-9 1998 The turnover time of the nuclear protein lasted for only 4 h although the suppressive effect of IFNgamma on Tg gene transcription lasted for 48 h. The effect of IFNgamma was lost when the thyrocytes were co-treated with genistein, a specific tyrosine kinase inhibitor. Genistein 220-229 interferon gamma Homo sapiens 96-104 9687151-9 1998 The turnover time of the nuclear protein lasted for only 4 h although the suppressive effect of IFNgamma on Tg gene transcription lasted for 48 h. The effect of IFNgamma was lost when the thyrocytes were co-treated with genistein, a specific tyrosine kinase inhibitor. Genistein 220-229 interferon gamma Homo sapiens 161-169 9744754-4 1998 Oligonucleotide target probe sets were designed for several human cytokines, including TNFalpha, IL-2, IL-4, IL-6, IL-10, and IFNgamma. Oligonucleotides 0-15 interferon gamma Homo sapiens 126-134 9762673-3 1998 There was a significant correlation with in vitro IFN-gamma release, the absolute blood monocyte count and the serum neopterin levels, suggesting that monocytes stimulated by IFN-gamma play an important role in the TNF-alpha production. Neopterin 117-126 interferon gamma Homo sapiens 175-184 10327418-7 1998 Tacrine, but not indomethacin, cimetidine, or propentofylline, showed activity in inhibiting C1q secretion by IFN-gamma treated THP-1-derived macrophages. Tacrine 0-7 interferon gamma Homo sapiens 110-119 9631139-2 1998 AIDS patients show increased serum tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma levels, which synergize with HIV-1-produced nitric oxide (NO) to augment viral replication. Nitric Oxide 141-153 interferon gamma Homo sapiens 74-96 9631139-5 1998 DESIGN AND METHODS: Linomide inhibits production of proinflammatory cytokines such as TNF-alpha, interleukin-1 beta and IFN-gamma, as well as iNOS synthesis. roquinimex 20-28 interferon gamma Homo sapiens 120-129 9631139-9 1998 Linomide also prevents human TNF-alpha and IFN-gamma production, as well as iNOS expression and affects the viral load, promoting potent suppression of HIV-1 infectivity as detected in peritoneal cavity and spleen. roquinimex 0-8 interferon gamma Homo sapiens 43-52 9671113-3 1998 The levels of serotonin transporter mRNA were increased by treatment with interferon-alpha and -gamma for 3 h. The increase in serotonin transporter mRNA elicited by the interferons was inhibited by treatment with actinomycin D, an inhibitor of transcription. Dactinomycin 214-227 interferon gamma Homo sapiens 74-101 9630160-7 1998 In contrast, mRNA expression of two inflammatory cytokines, TNFalpha and IFNgamma, decreased following steroid therapy. Steroids 103-110 interferon gamma Homo sapiens 73-81 9630166-2 1998 In this study, we examined the necessity of ser/thr and tyr kinase activity for IFN-gamma-induced stimulation of class II MHC gene expression in the human astroglioma cell lines CRT and CH235, as well as the involvement of these kinases in IFN-gamma-induced expression of the class II transactivator (CIITA), a protein critical for IFN-gamma-induced transcription of class II MHC genes. Serine 44-47 interferon gamma Homo sapiens 80-89 9630166-2 1998 In this study, we examined the necessity of ser/thr and tyr kinase activity for IFN-gamma-induced stimulation of class II MHC gene expression in the human astroglioma cell lines CRT and CH235, as well as the involvement of these kinases in IFN-gamma-induced expression of the class II transactivator (CIITA), a protein critical for IFN-gamma-induced transcription of class II MHC genes. Threonine 48-51 interferon gamma Homo sapiens 80-89 9603174-10 1998 Cyclosporine partially, but not completely, inhibits the development of CD30+ cells, and has a greater effect on interferon-gamma production than on interleukin-5 production. Cyclosporine 0-12 interferon gamma Homo sapiens 113-129 9569243-0 1998 Histamine affects interleukin-4, interleukin-5, and interferon-gamma production by human T cell clones from the airways and blood. Histamine 0-9 interferon gamma Homo sapiens 52-68 9569243-2 1998 This study describes the effects of histamine on anti-CD3-induced production of IL-4, IL-5, and IFN-gamma by T cell clones from subjects with allergic asthma and healthy subjects. Histamine 36-45 interferon gamma Homo sapiens 96-105 9569243-11 1998 The enhancement of IFN-gamma production by histamine, however, was found only in clones from healthy subjects. Histamine 43-52 interferon gamma Homo sapiens 19-28 9558364-9 1998 Moreover, treatment of desensitized DC with TNF-alpha plus prostaglandin E2 fully restored CD83 expression and partially restored IL-12 production as well as the IFN-gamma-inducing activity of DC in the mixed leukocyte reaction. Dinoprostone 59-75 interferon gamma Homo sapiens 162-171 10200495-6 1998 Following fourfold elevation in Fas expression in HT29 cells treated with interferon-gamma, a synergistic effect on Fas-mediated apoptosis was obtained when CH-11 and interferon-gamma were combined. ammonium ferrous sulfate 32-35 interferon gamma Homo sapiens 74-90 10200495-6 1998 Following fourfold elevation in Fas expression in HT29 cells treated with interferon-gamma, a synergistic effect on Fas-mediated apoptosis was obtained when CH-11 and interferon-gamma were combined. ammonium ferrous sulfate 32-35 interferon gamma Homo sapiens 167-183 10200495-6 1998 Following fourfold elevation in Fas expression in HT29 cells treated with interferon-gamma, a synergistic effect on Fas-mediated apoptosis was obtained when CH-11 and interferon-gamma were combined. ammonium ferrous sulfate 116-119 interferon gamma Homo sapiens 74-90 10200495-6 1998 Following fourfold elevation in Fas expression in HT29 cells treated with interferon-gamma, a synergistic effect on Fas-mediated apoptosis was obtained when CH-11 and interferon-gamma were combined. ammonium ferrous sulfate 116-119 interferon gamma Homo sapiens 167-183 9612607-9 1998 In contrast to these results, we found a significant decrease in IFN-alpha and IFN-gamma (19.8 +/- 3.6 U/ml, 4.6 +/- 1.5 U/ml before; 7.9 +/- 2.6 U/ml, 1.9 +/- 1.3 U/ml after administration of ZDV), a decrease in antipyrine half-life, an elevation of the antipyrine clearance (49.8 +/- 15.7 ml/min, 57.3 +/- 13.7 ml/min) and an elevation of the clearances to metabolite. Zidovudine 193-196 interferon gamma Homo sapiens 79-88 9612607-9 1998 In contrast to these results, we found a significant decrease in IFN-alpha and IFN-gamma (19.8 +/- 3.6 U/ml, 4.6 +/- 1.5 U/ml before; 7.9 +/- 2.6 U/ml, 1.9 +/- 1.3 U/ml after administration of ZDV), a decrease in antipyrine half-life, an elevation of the antipyrine clearance (49.8 +/- 15.7 ml/min, 57.3 +/- 13.7 ml/min) and an elevation of the clearances to metabolite. Antipyrine 213-223 interferon gamma Homo sapiens 79-88 9609368-4 1998 With insulin therapy and cessation of IFN-gamma, fasting blood glucose concentration returned to 6.2 mmol l(-1), and insulin therapy was discontinued. Glucose 63-70 interferon gamma Homo sapiens 38-47 9603452-2 1998 We studied the in vitro effect of CsA on IFN-gamma production. Cyclosporine 34-37 interferon gamma Homo sapiens 41-50 9603452-5 1998 IL-2 production was hardly affected by CsA under these stimulating conditions, while IFN-gamma (at the protein and mRNA level) was markedly stimulated by CsA. Cyclosporine 154-157 interferon gamma Homo sapiens 85-94 9603452-6 1998 The use of anti-CD3 or phorbol 12-myristate 13-acetate with ionomycin as the primary stimulus, together with costimulation through either CD28 or CD2 using transfectants with the appropriate ligands, allowed us to demonstrate that the resistance of IFN-gamma production to inhibition by CsA required both CD3 and CD28 triggering. Tetradecanoylphorbol Acetate 23-54 interferon gamma Homo sapiens 249-258 9603452-7 1998 Inhibition of IL-10 production, and to a lesser degree of IL-4 production, by CD4+ cells was responsible for the enhancement of IFN-gamma production in the presence of CsA. Cyclosporine 168-171 interferon gamma Homo sapiens 128-137 9603452-8 1998 In conclusion, IFN-gamma production by CD28-co-stimulated CD4+ T cells is resistant to inhibition by CsA and can even be facilitated by CsA as a result of removing a negative regulatory signal which is mainly IL-10 mediated. Cyclosporine 101-104 interferon gamma Homo sapiens 15-24 9603452-8 1998 In conclusion, IFN-gamma production by CD28-co-stimulated CD4+ T cells is resistant to inhibition by CsA and can even be facilitated by CsA as a result of removing a negative regulatory signal which is mainly IL-10 mediated. Cyclosporine 136-139 interferon gamma Homo sapiens 15-24 9603473-7 1998 Pretreatment of Fas-resistant CEA-positive colon carcinoma target cells with IFN-gamma increased their sensitivity of MD45-scFv subclones and FasL-mediated lysis. ammonium ferrous sulfate 16-19 interferon gamma Homo sapiens 77-86 9573098-5 1998 When RAW264.7 cells were pretreated with human TNF or TNF(70-80) in the presence of IFN-gamma, there was a dose-dependent reduction in the replication of BCG as measured by the uptake of 3H-labeled uracil and a concomitant release of nitric oxide as measured by the nitrite in the culture supernatants. Tritium 187-189 interferon gamma Homo sapiens 84-93 9573098-5 1998 When RAW264.7 cells were pretreated with human TNF or TNF(70-80) in the presence of IFN-gamma, there was a dose-dependent reduction in the replication of BCG as measured by the uptake of 3H-labeled uracil and a concomitant release of nitric oxide as measured by the nitrite in the culture supernatants. Uracil 198-204 interferon gamma Homo sapiens 84-93 9573098-5 1998 When RAW264.7 cells were pretreated with human TNF or TNF(70-80) in the presence of IFN-gamma, there was a dose-dependent reduction in the replication of BCG as measured by the uptake of 3H-labeled uracil and a concomitant release of nitric oxide as measured by the nitrite in the culture supernatants. Nitric Oxide 234-246 interferon gamma Homo sapiens 84-93 9573098-5 1998 When RAW264.7 cells were pretreated with human TNF or TNF(70-80) in the presence of IFN-gamma, there was a dose-dependent reduction in the replication of BCG as measured by the uptake of 3H-labeled uracil and a concomitant release of nitric oxide as measured by the nitrite in the culture supernatants. Nitrites 266-273 interferon gamma Homo sapiens 84-93 9623511-6 1998 Serum IFN-gamma was significantly lower in patients at the onset of ENL and was increased after 1 and 2 months of thalidomide treatment. Thalidomide 114-125 interferon gamma Homo sapiens 6-15 9556569-0 1998 The heparan sulfate binding sequence of interferon-gamma increased the on rate of the interferon-gamma-interferon-gamma receptor complex formation. Heparitin Sulfate 4-19 interferon gamma Homo sapiens 40-56 9556569-0 1998 The heparan sulfate binding sequence of interferon-gamma increased the on rate of the interferon-gamma-interferon-gamma receptor complex formation. Heparitin Sulfate 4-19 interferon gamma Homo sapiens 86-102 9556569-0 1998 The heparan sulfate binding sequence of interferon-gamma increased the on rate of the interferon-gamma-interferon-gamma receptor complex formation. Heparitin Sulfate 4-19 interferon gamma Homo sapiens 86-102 9556569-1 1998 Interferon-gamma (IFNgamma), in common with a number of growth factors, binds both to heparan sulfate or heparin-related molecules and to a specific high affinity receptor (IFNgammaR). Heparitin Sulfate 86-101 interferon gamma Homo sapiens 0-16 9556569-1 1998 Interferon-gamma (IFNgamma), in common with a number of growth factors, binds both to heparan sulfate or heparin-related molecules and to a specific high affinity receptor (IFNgammaR). Heparitin Sulfate 86-101 interferon gamma Homo sapiens 18-26 9556569-1 1998 Interferon-gamma (IFNgamma), in common with a number of growth factors, binds both to heparan sulfate or heparin-related molecules and to a specific high affinity receptor (IFNgammaR). Heparin 105-112 interferon gamma Homo sapiens 0-16 9556569-1 1998 Interferon-gamma (IFNgamma), in common with a number of growth factors, binds both to heparan sulfate or heparin-related molecules and to a specific high affinity receptor (IFNgammaR). Heparin 105-112 interferon gamma Homo sapiens 18-26 9556569-6 1998 This binding assay was used to investigate a possible role of heparin in the IFNgamma.IFNgammaR complex formation. Heparin 62-69 interferon gamma Homo sapiens 77-85 9556569-7 1998 In contrast to growth factors for which binding to heparin is usually required for high affinity receptor interaction, we found in this study that IFNgamma bound to heparin displayed a strongly reduced affinity for its receptor. Heparin 51-58 interferon gamma Homo sapiens 147-155 9556569-7 1998 In contrast to growth factors for which binding to heparin is usually required for high affinity receptor interaction, we found in this study that IFNgamma bound to heparin displayed a strongly reduced affinity for its receptor. Heparin 165-172 interferon gamma Homo sapiens 147-155 9556569-9 1998 To understand how a single domain of IFNgamma could be implicated in two discrete functions (i.e. binding to heparin and to IFNgammaR), we also analyzed in a detailed manner the role of the IFNgamma carboxyl-terminal sequence in receptor binding. Heparin 109-116 interferon gamma Homo sapiens 37-45 9556569-10 1998 Using forms of IFNgamma, with carboxyl terminus truncations of defined regions of the heparin binding sequence, we found that the C1 domain functioned by increasing the on rate of the IFNgamma.IFNgammaR binding reaction but was not otherwise required for the stability of the complex. Heparin 86-93 interferon gamma Homo sapiens 15-23 9556569-10 1998 Using forms of IFNgamma, with carboxyl terminus truncations of defined regions of the heparin binding sequence, we found that the C1 domain functioned by increasing the on rate of the IFNgamma.IFNgammaR binding reaction but was not otherwise required for the stability of the complex. Heparin 86-93 interferon gamma Homo sapiens 184-192 9556569-12 1998 The mechanisms by which heparan sulfate regulates IFNgamma activity may thus include both control of selective protease cleavage events, which directly affect the cytokine activity, and also an ability to modulate the interaction of IFNgamma with the IFNgammaR via competitive binding to the C1 domain. Heparitin Sulfate 24-39 interferon gamma Homo sapiens 50-58 9556569-12 1998 The mechanisms by which heparan sulfate regulates IFNgamma activity may thus include both control of selective protease cleavage events, which directly affect the cytokine activity, and also an ability to modulate the interaction of IFNgamma with the IFNgammaR via competitive binding to the C1 domain. Heparitin Sulfate 24-39 interferon gamma Homo sapiens 233-241 9574535-1 1998 Human gamma delta T cells have the ability to rapidly expand and produce IFN-gamma in response to nonpeptide Ags of microbial pathogens, in particular a class of compounds known as the prenyl phosphates. prenyl phosphates 185-202 interferon gamma Homo sapiens 73-82 9620355-4 1998 A number of analytical approaches have been developed recently to allow a detailed analysis of the carbohydrate structures associated with IFN-gamma, the principal advances being in the areas of capillary electrophoresis and mass spectrometry. Carbohydrates 99-111 interferon gamma Homo sapiens 139-148 9620356-4 1998 When ovalbumin-specific Th cells were cultured in the presence of 2,4,6 trinitrophenol (TNP)-specific B cells, M150 significantly increased the proliferation of Th cells and the secretion of IL-2 and IFN-gamma and decreased the production of IL-4. picric acid 66-86 interferon gamma Homo sapiens 200-209 9620356-4 1998 When ovalbumin-specific Th cells were cultured in the presence of 2,4,6 trinitrophenol (TNP)-specific B cells, M150 significantly increased the proliferation of Th cells and the secretion of IL-2 and IFN-gamma and decreased the production of IL-4. picric acid 88-91 interferon gamma Homo sapiens 200-209 9584220-0 1998 Interferon-gamma-inhibitory oligodeoxynucleotides alter the conformation of interferon-gamma. Oligodeoxyribonucleotides 28-49 interferon gamma Homo sapiens 0-16 9584220-0 1998 Interferon-gamma-inhibitory oligodeoxynucleotides alter the conformation of interferon-gamma. Oligodeoxyribonucleotides 28-49 interferon gamma Homo sapiens 76-92 9584220-3 1998 CD, fluorescence spectroscopy studies, and antibody binding studies in this system demonstrate that the interferon-gamma-inhibitory aptamer oligonucleotide causes significant changes in secondary and tertiary structures of interferon-gamma. Cadmium 0-2 interferon gamma Homo sapiens 104-120 9584220-3 1998 CD, fluorescence spectroscopy studies, and antibody binding studies in this system demonstrate that the interferon-gamma-inhibitory aptamer oligonucleotide causes significant changes in secondary and tertiary structures of interferon-gamma. Cadmium 0-2 interferon gamma Homo sapiens 223-239 9584220-3 1998 CD, fluorescence spectroscopy studies, and antibody binding studies in this system demonstrate that the interferon-gamma-inhibitory aptamer oligonucleotide causes significant changes in secondary and tertiary structures of interferon-gamma. Oligonucleotides 140-155 interferon gamma Homo sapiens 104-120 9584220-3 1998 CD, fluorescence spectroscopy studies, and antibody binding studies in this system demonstrate that the interferon-gamma-inhibitory aptamer oligonucleotide causes significant changes in secondary and tertiary structures of interferon-gamma. Oligonucleotides 140-155 interferon gamma Homo sapiens 223-239 9609229-0 1998 Cytokine gene expression in human LPS- and IFNgamma-stimulated mononuclear cells is inhibited by heparin. Heparin 97-104 interferon gamma Homo sapiens 43-51 9609229-3 1998 we studied the effect of heparin on IL-1beta, IL-6 and TNFalpha mRNAs in human lipopolysaccharide-(LPS)- or interferon-gamma(IFN-gamma)-stimulated mononuclear cells. Heparin 25-32 interferon gamma Homo sapiens 108-134 9545263-3 1998 We show here that, in a human monocytic cell line primed with interferon-gamma, FcgammaRI mobilizes intracellular calcium stores using a novel pathway that involves tyrosine kinase coupling to phospholipase D and resultant downstream activation of sphingosine kinase. Calcium 114-121 interferon gamma Homo sapiens 62-78 9719467-8 1998 Furthermore, the cytokines IL-1, TNFalpha, and IFNgamma are cytotoxic to beta-cells, in large part by inducing the formation of oxygen free radicals, nitric oxide, and peroxynitrite in the beta-cells themselves. oxygen free radicals 128-148 interferon gamma Homo sapiens 47-55 9719467-8 1998 Furthermore, the cytokines IL-1, TNFalpha, and IFNgamma are cytotoxic to beta-cells, in large part by inducing the formation of oxygen free radicals, nitric oxide, and peroxynitrite in the beta-cells themselves. Nitric Oxide 150-162 interferon gamma Homo sapiens 47-55 9719467-8 1998 Furthermore, the cytokines IL-1, TNFalpha, and IFNgamma are cytotoxic to beta-cells, in large part by inducing the formation of oxygen free radicals, nitric oxide, and peroxynitrite in the beta-cells themselves. Peroxynitrous Acid 168-181 interferon gamma Homo sapiens 47-55 9566801-10 1998 These results suggest that the production of IL-11 by rheumatoid synovia was differentially regulated by PGE2 and IFN-gamma, and that treatment with indomethacin or dexamethasone decreased the level of IL-11 at inflammatory joints in patients with RA. Indomethacin 149-161 interferon gamma Homo sapiens 114-123 9566801-10 1998 These results suggest that the production of IL-11 by rheumatoid synovia was differentially regulated by PGE2 and IFN-gamma, and that treatment with indomethacin or dexamethasone decreased the level of IL-11 at inflammatory joints in patients with RA. Dexamethasone 165-178 interferon gamma Homo sapiens 114-123 9617577-3 1998 Elevation of plasma cortisol within the physiological range by administration of cortisone acetate, 25 mg at 21.00, markedly suppressed IFN-gamma, TNF-alpha, IL-1 and IL-12 production, but not the later early morning rise of endogenous plasma cortisol. Cortisone 81-98 interferon gamma Homo sapiens 136-145 9616317-6 1998 Lysosomal aspartyl and thiol proteases were expressed but no HLA-DR surface expression was noted, (2) At 48 to 72 hours after IFN gamma stimulation, [3H]HRP equivalent fluxes increased significantly (7392 (1433) ng/h per cm2) without modification of the relative proportions of amino acids, peptides, and intact HRP, and without modification of the distribution of breakdown products in HPLC. Tritium 150-152 interferon gamma Homo sapiens 126-135 9499461-6 1998 Unstimulated and IL-2 stimulated lymphocytes secreted more TNF-alpha and IFN-gamma when cocultured with docetaxel treated HT-29 cells than with untreated cells. Docetaxel 104-113 interferon gamma Homo sapiens 73-82 9568729-3 1998 Similarly, arginine uptake and expression of the inducible nitric oxide synthase (iNOS) gene in response to bacterial DNA in BMM occurred only after IFN-gamma priming. Arginine 11-19 interferon gamma Homo sapiens 149-158 9562693-2 1998 Immunization with increasing doses of inactivated HIV-1 antigen in Incomplete Freund"s Adjuvant (IFA) resulted in increased production of IL-4 and IgG1 antibody with decreased production of interferon gamma. incomplete Freund's adjuvant 97-100 interferon gamma Homo sapiens 190-206 9562693-4 1998 Higher levels of interferon gamma were associated with immunization with inactivated HIV-1 antigen in Detox PC compared with inactivated HIV-1 in IFA or inactivated HIV-1 in saline. Sodium Chloride 174-180 interferon gamma Homo sapiens 17-33 9600638-2 1998 Treatment with interferon-gamma (100 U/ml) or the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA) (16.2 nM) induced ICAM-1 expression. Tetradecanoylphorbol Acetate 115-118 interferon gamma Homo sapiens 15-31 9510155-6 1998 PD98059 inhibited TNF-alpha, IL-3, granulocyte-macrophage (GM)-CSF, IFN-gamma, and to a lesser extent IL-6 and IL-10 production but enhanced IL-4, IL-5, and IL-13 production induced by CD3/PMA or CD3/CD28. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 interferon gamma Homo sapiens 68-77 9510155-8 1998 FK506 also reduced CD3/CD28-induced production of IL-3, IL-4, IL-10, TNF-alpha, and IL-6 but augmented that of GM-CSF, IL-5, IFN-gamma, and IL-13. Tacrolimus 0-5 interferon gamma Homo sapiens 125-134 9521862-7 1998 Using HL-60 cells fluorescently labeled by TMA-DPH, similar results indicating fluidization of the membrane following IFN-gamma treatment were obtained. 1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene 43-50 interferon gamma Homo sapiens 118-127 9534884-0 1998 Free radicals as potential mediators of metal allergy: effect of ascorbic acid on lymphocyte proliferation and IFN-gamma production in contact allergy to Ni2+ and Co2+. Nickel(2+) 154-158 interferon gamma Homo sapiens 111-120 9534884-3 1998 The immune response was characterized by cellular [methyl-3H]thymidine uptake and interferon-gamma (IFN-gamma) production Ni2+ and Co2+ (10-50 microM) significantly increased lymphocyte proliferation and IFN-gamma production in PBMC cultures from contact allergic subjects in comparison with cultures from controls. Nickel(2+) 122-126 interferon gamma Homo sapiens 82-98 9534884-3 1998 The immune response was characterized by cellular [methyl-3H]thymidine uptake and interferon-gamma (IFN-gamma) production Ni2+ and Co2+ (10-50 microM) significantly increased lymphocyte proliferation and IFN-gamma production in PBMC cultures from contact allergic subjects in comparison with cultures from controls. Nickel(2+) 122-126 interferon gamma Homo sapiens 100-109 9534884-3 1998 The immune response was characterized by cellular [methyl-3H]thymidine uptake and interferon-gamma (IFN-gamma) production Ni2+ and Co2+ (10-50 microM) significantly increased lymphocyte proliferation and IFN-gamma production in PBMC cultures from contact allergic subjects in comparison with cultures from controls. Nickel(2+) 122-126 interferon gamma Homo sapiens 204-213 9534884-3 1998 The immune response was characterized by cellular [methyl-3H]thymidine uptake and interferon-gamma (IFN-gamma) production Ni2+ and Co2+ (10-50 microM) significantly increased lymphocyte proliferation and IFN-gamma production in PBMC cultures from contact allergic subjects in comparison with cultures from controls. Cobalt(2+) 131-135 interferon gamma Homo sapiens 82-98 9534884-3 1998 The immune response was characterized by cellular [methyl-3H]thymidine uptake and interferon-gamma (IFN-gamma) production Ni2+ and Co2+ (10-50 microM) significantly increased lymphocyte proliferation and IFN-gamma production in PBMC cultures from contact allergic subjects in comparison with cultures from controls. Cobalt(2+) 131-135 interferon gamma Homo sapiens 100-109 9534884-3 1998 The immune response was characterized by cellular [methyl-3H]thymidine uptake and interferon-gamma (IFN-gamma) production Ni2+ and Co2+ (10-50 microM) significantly increased lymphocyte proliferation and IFN-gamma production in PBMC cultures from contact allergic subjects in comparison with cultures from controls. Cobalt(2+) 131-135 interferon gamma Homo sapiens 204-213 9542602-3 1998 In most patients, we found reduced frequencies of T cells recalled to express CD69 and the cytokines interleukin (IL)-4 and interferon-gamma (IFN-gamma) after stimulation of peripheral blood mononuclear cells with phorbol 12-myristate 13-acetate (PMA) and ionomycin, as compared with normal donors. Tetradecanoylphorbol Acetate 214-245 interferon gamma Homo sapiens 124-140 9542602-3 1998 In most patients, we found reduced frequencies of T cells recalled to express CD69 and the cytokines interleukin (IL)-4 and interferon-gamma (IFN-gamma) after stimulation of peripheral blood mononuclear cells with phorbol 12-myristate 13-acetate (PMA) and ionomycin, as compared with normal donors. Tetradecanoylphorbol Acetate 214-245 interferon gamma Homo sapiens 142-151 9542602-3 1998 In most patients, we found reduced frequencies of T cells recalled to express CD69 and the cytokines interleukin (IL)-4 and interferon-gamma (IFN-gamma) after stimulation of peripheral blood mononuclear cells with phorbol 12-myristate 13-acetate (PMA) and ionomycin, as compared with normal donors. Tetradecanoylphorbol Acetate 247-250 interferon gamma Homo sapiens 142-151 9542602-3 1998 In most patients, we found reduced frequencies of T cells recalled to express CD69 and the cytokines interleukin (IL)-4 and interferon-gamma (IFN-gamma) after stimulation of peripheral blood mononuclear cells with phorbol 12-myristate 13-acetate (PMA) and ionomycin, as compared with normal donors. Ionomycin 256-265 interferon gamma Homo sapiens 142-151 9506551-2 1998 Here, we report that in patients with MS the combined action of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-2, and IL-6 leads to the activation of most peripheral T cells (mainly CD4 memory) by promoting a persistent intracellular calcium increase via two independent signaling pathways. Calcium 274-281 interferon gamma Homo sapiens 64-80 9506551-2 1998 Here, we report that in patients with MS the combined action of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-2, and IL-6 leads to the activation of most peripheral T cells (mainly CD4 memory) by promoting a persistent intracellular calcium increase via two independent signaling pathways. Calcium 274-281 interferon gamma Homo sapiens 82-91 9511463-4 1998 For assaying the antigen IFN-gamma, a 16-kDa cytokine, a capture monoclonal antibody is physically adsorbed onto the polystyrene surface. Polystyrenes 117-128 interferon gamma Homo sapiens 25-34 9528885-2 1998 The production of IFN-gamma and IL-4 and the development of Th cells into either high IFN-gamma or high IL-4 producers is strongly influenced by factors produced by antigen-presenting cells (APC), like IL-12 and prostaglandin E2 (PGE2). Dinoprostone 212-228 interferon gamma Homo sapiens 18-27 9528885-2 1998 The production of IFN-gamma and IL-4 and the development of Th cells into either high IFN-gamma or high IL-4 producers is strongly influenced by factors produced by antigen-presenting cells (APC), like IL-12 and prostaglandin E2 (PGE2). Dinoprostone 212-228 interferon gamma Homo sapiens 86-95 9528885-4 1998 The aim of this study was to test whether the increased IL-4/IFN-gamma production ratio by Th cells in AD can be explained by an increased PGE2/IL-12 production ratio by the APC. Dinoprostone 139-143 interferon gamma Homo sapiens 61-70 9553912-0 1998 Plasma concentrations of IFN-gamma and TNF-alpha in psoriatic patients before and after local treatment with dithranol ointment. Anthralin 109-118 interferon gamma Homo sapiens 25-34 9651816-10 1998 Although the addition of 12-o-tetradecanoylphorbol-13-acetate (TPA) singly to the incubation medium had no effect on either Mn-, or Cu,Zn-SOD activity, it significantly augmented the IFN-gamma-dependent induction of Mn-SOD activity by anti-Fas antibody or by TNF-alpha. Tetradecanoylphorbol Acetate 25-61 interferon gamma Homo sapiens 183-192 9651816-10 1998 Although the addition of 12-o-tetradecanoylphorbol-13-acetate (TPA) singly to the incubation medium had no effect on either Mn-, or Cu,Zn-SOD activity, it significantly augmented the IFN-gamma-dependent induction of Mn-SOD activity by anti-Fas antibody or by TNF-alpha. Tetradecanoylphorbol Acetate 63-66 interferon gamma Homo sapiens 183-192 9498755-9 1998 Furthermore, these two classes of IL-12 inhibitors synergistically decreased hulL-12-stimulated proliferation and IFN-gamma production. hull-12 77-84 interferon gamma Homo sapiens 114-123 9555982-0 1998 IFN-gamma induces calcium transients and increases the capacitative calcium entry in human neutrophils. Calcium 18-25 interferon gamma Homo sapiens 0-9 9555982-0 1998 IFN-gamma induces calcium transients and increases the capacitative calcium entry in human neutrophils. Calcium 68-75 interferon gamma Homo sapiens 0-9 9555982-1 1998 We have previously reported that long-term priming of human polymorphonuclear neutrophilic granulocytes (PMN) with interferon-gamma (IFN-gamma) increased the fMLP-stimulated calcium influx. Calcium 174-181 interferon gamma Homo sapiens 115-131 9555982-1 1998 We have previously reported that long-term priming of human polymorphonuclear neutrophilic granulocytes (PMN) with interferon-gamma (IFN-gamma) increased the fMLP-stimulated calcium influx. Calcium 174-181 interferon gamma Homo sapiens 133-142 9555982-2 1998 We now show that also after short-term incubation with IFN-gamma, PMN calcium metabolism is modulated. Calcium 70-77 interferon gamma Homo sapiens 55-64 9555982-4 1998 The results of this protocol indicated that IFN-gamma increases both calcium influx and calcium sequestration. Calcium 69-76 interferon gamma Homo sapiens 44-53 9555982-4 1998 The results of this protocol indicated that IFN-gamma increases both calcium influx and calcium sequestration. Calcium 88-95 interferon gamma Homo sapiens 44-53 9555982-5 1998 Store dependent Ca2+ influx, directly measured on readdition of calcium to Tg-treated cells incubated in EGTA buffer, was significantly enhanced in IFN-gamma-treated cells. Calcium 64-71 interferon gamma Homo sapiens 148-157 9555982-5 1998 Store dependent Ca2+ influx, directly measured on readdition of calcium to Tg-treated cells incubated in EGTA buffer, was significantly enhanced in IFN-gamma-treated cells. Thapsigargin 75-77 interferon gamma Homo sapiens 148-157 9555982-5 1998 Store dependent Ca2+ influx, directly measured on readdition of calcium to Tg-treated cells incubated in EGTA buffer, was significantly enhanced in IFN-gamma-treated cells. Egtazic Acid 105-109 interferon gamma Homo sapiens 148-157 9555982-6 1998 This effect of IFN-gamma was enhanced by the tyrosine kinase inhibitor herbimycin A. herbimycin 71-83 interferon gamma Homo sapiens 15-24 9555982-7 1998 Strikingly, in low extracellular calcium concentrations, IFN-gamma induced calcium transients in 20%-60% of the cells. Calcium 33-40 interferon gamma Homo sapiens 57-66 9555982-7 1998 Strikingly, in low extracellular calcium concentrations, IFN-gamma induced calcium transients in 20%-60% of the cells. Calcium 75-82 interferon gamma Homo sapiens 57-66 9555982-9 1998 Average lagtime from addition of IFN-gamma to a response that could be measured was 7.3 sec, and average increase in [Ca2+] above the basal level was 790 nM. lagtime 8-15 interferon gamma Homo sapiens 33-42 9555982-11 1998 Thus, IFN-gamma can increase capacitative calcium influx, induce calcium transients, and possibly affect calcium sequestration in human PMN. Calcium 42-49 interferon gamma Homo sapiens 6-15 9555982-11 1998 Thus, IFN-gamma can increase capacitative calcium influx, induce calcium transients, and possibly affect calcium sequestration in human PMN. Calcium 65-72 interferon gamma Homo sapiens 6-15 9555982-11 1998 Thus, IFN-gamma can increase capacitative calcium influx, induce calcium transients, and possibly affect calcium sequestration in human PMN. Calcium 65-72 interferon gamma Homo sapiens 6-15 9640627-4 1998 On ionomycin + PMA stimulation, which reveals the intrinsic potential of lymphokine production by T cells, the CD57+ T cell subsets from all individuals produced high amounts of IFN-gamma and TNF-alpha mRNA and protein. Ionomycin 3-12 interferon gamma Homo sapiens 178-187 9640627-4 1998 On ionomycin + PMA stimulation, which reveals the intrinsic potential of lymphokine production by T cells, the CD57+ T cell subsets from all individuals produced high amounts of IFN-gamma and TNF-alpha mRNA and protein. Tetradecanoylphorbol Acetate 15-18 interferon gamma Homo sapiens 178-187 9468523-2 1998 Because interferon-gamma (IFN-gamma), a cytokine with known antiproliferative and antitumoral activity, binds with high affinity to the heparan sulfate side chains of perlecan, we investigated the activity of IFN-gamma on perlecan gene expression and cell growth in colon carcinoma cells. Heparitin Sulfate 136-151 interferon gamma Homo sapiens 8-24 9468523-2 1998 Because interferon-gamma (IFN-gamma), a cytokine with known antiproliferative and antitumoral activity, binds with high affinity to the heparan sulfate side chains of perlecan, we investigated the activity of IFN-gamma on perlecan gene expression and cell growth in colon carcinoma cells. Heparitin Sulfate 136-151 interferon gamma Homo sapiens 26-35 9570473-6 1998 Unlike its effect on cell proliferation, oxatomide potentiated the Dermatophagoides farinae-induced production of interferon-gamma, which was suppressed by stimulation with Dermatophagoides farinae antigen in lymphocytes from the patients. oxatomide 41-50 interferon gamma Homo sapiens 114-130 9570473-8 1998 These results indicate that oxatomide suppresses interleukin-2 responsiveness of allergen-activated helper T-cells and increases the production of interferon-gamma induced by Dermatophagoides farinae antigen, without causing cell proliferation. oxatomide 28-37 interferon gamma Homo sapiens 147-163 9454753-8 1998 CH-11 anti-Fas antibody, which mimics the action of the natural FasL, greatly enhanced IFNgamma-mediated suppression of cell growth and production of apoptosis, indicating that Fas is functional. 4-dimethylamino-3',4'-dimethoxychalcone 0-5 interferon gamma Homo sapiens 87-95 9454753-8 1998 CH-11 anti-Fas antibody, which mimics the action of the natural FasL, greatly enhanced IFNgamma-mediated suppression of cell growth and production of apoptosis, indicating that Fas is functional. ammonium ferrous sulfate 11-14 interferon gamma Homo sapiens 87-95 9454765-5 1998 The IL-12-induced tyrosine phosphorylation of STAT5 and STAT1, but not STAT4, is augmented in T cells activated into Th1 cells with PHA + interferon-gamma (IFN-gamma) compared with T cells activated with PHA alone. Tyrosine 18-26 interferon gamma Homo sapiens 138-154 9454765-5 1998 The IL-12-induced tyrosine phosphorylation of STAT5 and STAT1, but not STAT4, is augmented in T cells activated into Th1 cells with PHA + interferon-gamma (IFN-gamma) compared with T cells activated with PHA alone. Tyrosine 18-26 interferon gamma Homo sapiens 156-165 9485044-3 1998 We showed that janus kinase 2 (JAK2) and signal transducer and activator of transcription 1 (STAT1) were phosphorylated on tyrosine residues within 15 min in all the HMCLs in which IFN-gamma (500 units/ml) inhibited proliferation. Tyrosine 123-131 interferon gamma Homo sapiens 181-190 9514309-6 1998 However, we found that monocyte activation with interferon-gamma (IFN-gamma) can prevent the preferential IL-10 induction by ethanol. Ethanol 125-132 interferon gamma Homo sapiens 48-64 9514309-6 1998 However, we found that monocyte activation with interferon-gamma (IFN-gamma) can prevent the preferential IL-10 induction by ethanol. Ethanol 125-132 interferon gamma Homo sapiens 66-75 9514309-7 1998 IFN-gamma (100 units/ml) inhibited monocyte IL-10 production whether induced by 1 microg/ml of lipopolysaccharide (p < 0.01), 1 microg/ml of SEB (p < 0.02), or a combination of bacterial stimulation + ethanol (lipopolysaccharide: p < 0.01). Ethanol 207-214 interferon gamma Homo sapiens 0-9 9514309-9 1998 Moreover, acute ethanol treatment augmented IL-12 production in IFN-gamma-treated monocytes in response to SEB stimulation (25 mM ethanol, p < 0.01; 100 mM ethanol, p < 0.01). Ethanol 16-23 interferon gamma Homo sapiens 64-73 9514309-9 1998 Moreover, acute ethanol treatment augmented IL-12 production in IFN-gamma-treated monocytes in response to SEB stimulation (25 mM ethanol, p < 0.01; 100 mM ethanol, p < 0.01). Ethanol 130-137 interferon gamma Homo sapiens 64-73 9514309-9 1998 Moreover, acute ethanol treatment augmented IL-12 production in IFN-gamma-treated monocytes in response to SEB stimulation (25 mM ethanol, p < 0.01; 100 mM ethanol, p < 0.01). Ethanol 130-137 interferon gamma Homo sapiens 64-73 9514309-11 1998 These results suggest that inhibition of ethanol-induced IL-10 production by IFN-gamma treatment is permissive for IL-12 induction by alcohol stimulation in monocytes. Ethanol 41-48 interferon gamma Homo sapiens 77-86 9514309-11 1998 These results suggest that inhibition of ethanol-induced IL-10 production by IFN-gamma treatment is permissive for IL-12 induction by alcohol stimulation in monocytes. Alcohols 134-141 interferon gamma Homo sapiens 77-86 9514309-12 1998 Thus, our results imply that the presence or absence of IFN-gamma is critical in determining the effect of acute ethanol treatment on monocyte IL-12 versus IL-10 induction. Ethanol 113-120 interferon gamma Homo sapiens 56-65 9458101-9 1998 Phorbol 12-myristate 13-acetate inhibited CD95-mediated apoptosis by counteracting the IFNgamma-, actinomycin D-, and cycloheximide-mediated but not the brefeldin A-mediated sensitization. Tetradecanoylphorbol Acetate 0-31 interferon gamma Homo sapiens 87-95 9486420-10 1998 Moreover, since dexamethasone responsiveness of anti-CD2/anti-CD28 MoAb-induced IFN-gamma secretion in whole blood is not affected by exercise, it may suggest that exercise differentially affects monocytes and lymphocytes. Dexamethasone 16-29 interferon gamma Homo sapiens 80-89 9502476-2 1998 Because of the severe side effects of therapy with benzimidazoles, we treated a patient with recombinant interferon gamma at a dose of 250 microg over a 3-day period once a month. Benzimidazoles 51-65 interferon gamma Homo sapiens 105-121 9502171-8 1998 Similarly, dbcAMP inhibited the production of IFN-gamma and IL-2 more potently than IL-4 and IL-5. Bucladesine 11-17 interferon gamma Homo sapiens 46-55 9551730-6 1998 Serum IL-4, IL-5 and IFN-gamma levels were significantly higher in asthmatic subjects as compared to healthy controls, both at 16:00 and 04:00 h. In asthmatic subjects serum IFN-gamma at both time points correlated significantly with the provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second (PC20,meth) (rho= - 0.55) and with the mean 16:00-04:00 h PEF variation (rho = 0.53). Methacholine Chloride 267-279 interferon gamma Homo sapiens 174-183 9551730-6 1998 Serum IL-4, IL-5 and IFN-gamma levels were significantly higher in asthmatic subjects as compared to healthy controls, both at 16:00 and 04:00 h. In asthmatic subjects serum IFN-gamma at both time points correlated significantly with the provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second (PC20,meth) (rho= - 0.55) and with the mean 16:00-04:00 h PEF variation (rho = 0.53). Methamphetamine 267-271 interferon gamma Homo sapiens 174-183 9513813-0 1998 Evidence of molten globule like state(s) of interferon gamma in acidic and sodium perchlorate solutions. sodium perchlorate 75-93 interferon gamma Homo sapiens 44-60 9513813-1 1998 Recombinant porcine interferon gamma (IFN gamma) at neutral pH is characterized by a tryptophan (Trp) fluorescence maximum around 343 nm and a rigid conformation, evidenced from tryptophan polarization values. Tryptophan 85-95 interferon gamma Homo sapiens 20-36 9513813-1 1998 Recombinant porcine interferon gamma (IFN gamma) at neutral pH is characterized by a tryptophan (Trp) fluorescence maximum around 343 nm and a rigid conformation, evidenced from tryptophan polarization values. Tryptophan 85-95 interferon gamma Homo sapiens 38-47 9513813-1 1998 Recombinant porcine interferon gamma (IFN gamma) at neutral pH is characterized by a tryptophan (Trp) fluorescence maximum around 343 nm and a rigid conformation, evidenced from tryptophan polarization values. Tryptophan 97-100 interferon gamma Homo sapiens 20-36 9513813-1 1998 Recombinant porcine interferon gamma (IFN gamma) at neutral pH is characterized by a tryptophan (Trp) fluorescence maximum around 343 nm and a rigid conformation, evidenced from tryptophan polarization values. Tryptophan 97-100 interferon gamma Homo sapiens 38-47 9513813-1 1998 Recombinant porcine interferon gamma (IFN gamma) at neutral pH is characterized by a tryptophan (Trp) fluorescence maximum around 343 nm and a rigid conformation, evidenced from tryptophan polarization values. Tryptophan 178-188 interferon gamma Homo sapiens 20-36 9513813-1 1998 Recombinant porcine interferon gamma (IFN gamma) at neutral pH is characterized by a tryptophan (Trp) fluorescence maximum around 343 nm and a rigid conformation, evidenced from tryptophan polarization values. Tryptophan 178-188 interferon gamma Homo sapiens 38-47 9513813-2 1998 Guanidine HCl shifts the protein emission spectra further to the red and decreases the fluorescence polarization values, indicating denatured IFN gamma in these solutions. Guanidine 0-13 interferon gamma Homo sapiens 142-151 9513813-6 1998 The extent of quenching of tryptophan fluorescence by acrylamide is less in acid and in NaClO4 solutions of IFN gamma compared to its native form. Tryptophan 27-37 interferon gamma Homo sapiens 108-117 9513813-6 1998 The extent of quenching of tryptophan fluorescence by acrylamide is less in acid and in NaClO4 solutions of IFN gamma compared to its native form. Acrylamide 54-64 interferon gamma Homo sapiens 108-117 9513813-6 1998 The extent of quenching of tryptophan fluorescence by acrylamide is less in acid and in NaClO4 solutions of IFN gamma compared to its native form. sodium perchlorate 88-94 interferon gamma Homo sapiens 108-117 9513813-8 1998 The emission spectra of IFN gamma in NaClO4 solution shows a decrease in the tryptophan fluorescence intensity with simultaneous shift of the emission spectra over time. sodium perchlorate 37-43 interferon gamma Homo sapiens 24-33 9513813-8 1998 The emission spectra of IFN gamma in NaClO4 solution shows a decrease in the tryptophan fluorescence intensity with simultaneous shift of the emission spectra over time. Tryptophan 77-87 interferon gamma Homo sapiens 24-33 9513813-9 1998 The presence of two conformational forms of IFN gamma in perchlorate solution is evidenced from an isofluorescent point at 315 nm. perchlorate 57-68 interferon gamma Homo sapiens 44-53 9513813-14 1998 Similarities of the protein fluorescence and 1-anilino-8-naphthalene-sulfonic-acid (ANS) binding properties of the protein in NaClO4 and acid solutions indicate that IFN gamma also exists in a molten globule-like state in perchlorate solution at neutral pH. 1-anilino-8-naphthalenesulfonate 45-82 interferon gamma Homo sapiens 166-175 9513813-14 1998 Similarities of the protein fluorescence and 1-anilino-8-naphthalene-sulfonic-acid (ANS) binding properties of the protein in NaClO4 and acid solutions indicate that IFN gamma also exists in a molten globule-like state in perchlorate solution at neutral pH. 1-anilino-8-naphthalenesulfonate 84-87 interferon gamma Homo sapiens 166-175 9513813-14 1998 Similarities of the protein fluorescence and 1-anilino-8-naphthalene-sulfonic-acid (ANS) binding properties of the protein in NaClO4 and acid solutions indicate that IFN gamma also exists in a molten globule-like state in perchlorate solution at neutral pH. sodium perchlorate 126-132 interferon gamma Homo sapiens 166-175 9513813-14 1998 Similarities of the protein fluorescence and 1-anilino-8-naphthalene-sulfonic-acid (ANS) binding properties of the protein in NaClO4 and acid solutions indicate that IFN gamma also exists in a molten globule-like state in perchlorate solution at neutral pH. perchlorate 222-233 interferon gamma Homo sapiens 166-175 9543699-0 1998 Effect of propranolol and IFN-beta on the induction of MHC class II expression and cytokine production by IFN-gamma IN THP-1 human monocytic cells. Propranolol 10-21 interferon gamma Homo sapiens 106-115 9543699-1 1998 This study was undertaken to investigate the effects of propranolol, IFN-beta, and the protein kinase modulators on IFN-gamma induction of MHC class II antigen expression and cytokine production in THP-1 human monocytic cells. Propranolol 56-67 interferon gamma Homo sapiens 116-125 9543699-4 1998 H-7, phloretin, staurosporine as well as GF 109203X are selective enzyme inhibitors of protein kinase C (PKC), down-regulating IFN-gamma induced MHC class II expression and cytokine production. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 0-3 interferon gamma Homo sapiens 127-136 9543699-4 1998 H-7, phloretin, staurosporine as well as GF 109203X are selective enzyme inhibitors of protein kinase C (PKC), down-regulating IFN-gamma induced MHC class II expression and cytokine production. Phloretin 5-14 interferon gamma Homo sapiens 127-136 9543699-4 1998 H-7, phloretin, staurosporine as well as GF 109203X are selective enzyme inhibitors of protein kinase C (PKC), down-regulating IFN-gamma induced MHC class II expression and cytokine production. Staurosporine 16-29 interferon gamma Homo sapiens 127-136 9543699-4 1998 H-7, phloretin, staurosporine as well as GF 109203X are selective enzyme inhibitors of protein kinase C (PKC), down-regulating IFN-gamma induced MHC class II expression and cytokine production. bisindolylmaleimide I 41-51 interferon gamma Homo sapiens 127-136 9543699-6 1998 Blocking of phospholipase D (PLD)-derived diacylglycerol (DAG) formation by propranolol abrogated IFN-gamma increased HLA class II expression and IL-1 beta secretion, but had little effect on IFN-gamma induced TNF-alpha production. Diglycerides 42-56 interferon gamma Homo sapiens 98-107 9543699-6 1998 Blocking of phospholipase D (PLD)-derived diacylglycerol (DAG) formation by propranolol abrogated IFN-gamma increased HLA class II expression and IL-1 beta secretion, but had little effect on IFN-gamma induced TNF-alpha production. Diglycerides 58-61 interferon gamma Homo sapiens 98-107 9543699-6 1998 Blocking of phospholipase D (PLD)-derived diacylglycerol (DAG) formation by propranolol abrogated IFN-gamma increased HLA class II expression and IL-1 beta secretion, but had little effect on IFN-gamma induced TNF-alpha production. Diglycerides 58-61 interferon gamma Homo sapiens 192-201 9543699-6 1998 Blocking of phospholipase D (PLD)-derived diacylglycerol (DAG) formation by propranolol abrogated IFN-gamma increased HLA class II expression and IL-1 beta secretion, but had little effect on IFN-gamma induced TNF-alpha production. Propranolol 76-87 interferon gamma Homo sapiens 98-107 9543699-7 1998 These findings appear to suggest that PLD-derived phosphatidate is not the primary source of DAG production in IFN-gamma-induced TNF-alpha secretion, but may be necessary for IFN-gamma-mediated MHC class II induction and IL-1 beta production in human monocytes, whereas phospholipase A2 may not be required for IFN-gamma activation of PKC in the process. phosphatidate 50-63 interferon gamma Homo sapiens 175-184 9543699-7 1998 These findings appear to suggest that PLD-derived phosphatidate is not the primary source of DAG production in IFN-gamma-induced TNF-alpha secretion, but may be necessary for IFN-gamma-mediated MHC class II induction and IL-1 beta production in human monocytes, whereas phospholipase A2 may not be required for IFN-gamma activation of PKC in the process. phosphatidate 50-63 interferon gamma Homo sapiens 175-184 9538194-0 1998 Protective effect of linoleic acid on IFN gamma-induced cellular injury in primary culture hepatocytes. Linoleic Acid 21-34 interferon gamma Homo sapiens 38-47 9538194-3 1998 Polyunsaturated fatty acids (PUFAs) increased cellular respiration of hepatocytes, but only linoleic acid showed some protective effect against IFN gamma-induced cellular respiration suppression. Linoleic Acid 92-105 interferon gamma Homo sapiens 144-153 9538194-4 1998 Linoleic acid also reduced other IFN gamma-mediated cellular injuries, including membrane breakage and protein synthesis inhibition. Linoleic Acid 0-13 interferon gamma Homo sapiens 33-42 9538194-5 1998 Like linoleic acid, fetal bovine serum also inhibited IFN gamma-induced cellular damage. Linoleic Acid 5-18 interferon gamma Homo sapiens 54-63 9538194-6 1998 Increased NAD levels were found in both IFN gamma-treated and non-treated hepatocytes following the addition of PUFAs, but clofibrate, a peroxisome proliferator, bromophenacyl bromide (BPB), an inhibitor of phospholipase, nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, and arachidonic acid, a metabolite of linoleic acid, did not inhibit IFN gamma-induced cellular injury. NAD 10-13 interferon gamma Homo sapiens 40-49 9538194-6 1998 Increased NAD levels were found in both IFN gamma-treated and non-treated hepatocytes following the addition of PUFAs, but clofibrate, a peroxisome proliferator, bromophenacyl bromide (BPB), an inhibitor of phospholipase, nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, and arachidonic acid, a metabolite of linoleic acid, did not inhibit IFN gamma-induced cellular injury. NAD 10-13 interferon gamma Homo sapiens 355-364 9538194-6 1998 Increased NAD levels were found in both IFN gamma-treated and non-treated hepatocytes following the addition of PUFAs, but clofibrate, a peroxisome proliferator, bromophenacyl bromide (BPB), an inhibitor of phospholipase, nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, and arachidonic acid, a metabolite of linoleic acid, did not inhibit IFN gamma-induced cellular injury. Fatty Acids, Unsaturated 112-117 interferon gamma Homo sapiens 40-49 9538194-6 1998 Increased NAD levels were found in both IFN gamma-treated and non-treated hepatocytes following the addition of PUFAs, but clofibrate, a peroxisome proliferator, bromophenacyl bromide (BPB), an inhibitor of phospholipase, nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, and arachidonic acid, a metabolite of linoleic acid, did not inhibit IFN gamma-induced cellular injury. 4-bromophenacyl bromide 185-188 interferon gamma Homo sapiens 40-49 9538194-6 1998 Increased NAD levels were found in both IFN gamma-treated and non-treated hepatocytes following the addition of PUFAs, but clofibrate, a peroxisome proliferator, bromophenacyl bromide (BPB), an inhibitor of phospholipase, nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, and arachidonic acid, a metabolite of linoleic acid, did not inhibit IFN gamma-induced cellular injury. Masoprocol 222-247 interferon gamma Homo sapiens 40-49 9538194-6 1998 Increased NAD levels were found in both IFN gamma-treated and non-treated hepatocytes following the addition of PUFAs, but clofibrate, a peroxisome proliferator, bromophenacyl bromide (BPB), an inhibitor of phospholipase, nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, and arachidonic acid, a metabolite of linoleic acid, did not inhibit IFN gamma-induced cellular injury. Masoprocol 249-253 interferon gamma Homo sapiens 40-49 9538194-6 1998 Increased NAD levels were found in both IFN gamma-treated and non-treated hepatocytes following the addition of PUFAs, but clofibrate, a peroxisome proliferator, bromophenacyl bromide (BPB), an inhibitor of phospholipase, nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, and arachidonic acid, a metabolite of linoleic acid, did not inhibit IFN gamma-induced cellular injury. Arachidonic Acid 290-306 interferon gamma Homo sapiens 40-49 9538194-6 1998 Increased NAD levels were found in both IFN gamma-treated and non-treated hepatocytes following the addition of PUFAs, but clofibrate, a peroxisome proliferator, bromophenacyl bromide (BPB), an inhibitor of phospholipase, nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, and arachidonic acid, a metabolite of linoleic acid, did not inhibit IFN gamma-induced cellular injury. Linoleic Acid 324-337 interferon gamma Homo sapiens 40-49 9538194-7 1998 In addition, the combination of linoleic acid and IFN gamma induced nitric oxide (NO) synthesis in hepatocytes. Nitric Oxide 68-80 interferon gamma Homo sapiens 50-59 9466535-5 1998 Surprisingly, interferon-gamma production in patients and controls was equally sensitive to DEX. Dexamethasone 92-95 interferon gamma Homo sapiens 14-30 9600205-4 1998 In SK-N-SH cells, a 48 hour (h) treatment with 100 ng/ml IL-1beta, 100 ng/ml TNF-alpha, or 100 nM phorbol 12-myristate 13-acetate induced a 2.7- to 4.2-fold increase in the level of PrP mRNA, while the exposure to 100 ng/ml IFN-gamma resulted in a 50% decrease. Tetradecanoylphorbol Acetate 98-129 interferon gamma Homo sapiens 224-233 9463483-0 1998 Modulation of fluorouracil cytotoxicity by interferon-alpha and -gamma. Fluorouracil 14-26 interferon gamma Homo sapiens 43-70 9548401-0 1998 Glatiramer acetate blocks the activation of THP-1 cells by interferon-gamma. Glatiramer Acetate 0-18 interferon gamma Homo sapiens 59-75 9462716-8 1998 Exposure to the combination of IFN-gamma plus retinoic acid significantly up-regulated (in an additive manner) HLA-Class-I and ICAM-1 molecules as compared with the levels obtainable after exposure to IFN-gamma alone. Tretinoin 46-59 interferon gamma Homo sapiens 201-210 9871640-2 1998 The most potent of these, 2-amino-5-methyl-S-phenyl cysteine S,S-dioxide 6d, inhibits interferon-gamma induced synthesis of quinolinic acid in human macrophages. 2-amino-5-methyl-s-phenyl cysteine 26-60 interferon gamma Homo sapiens 86-102 9871640-2 1998 The most potent of these, 2-amino-5-methyl-S-phenyl cysteine S,S-dioxide 6d, inhibits interferon-gamma induced synthesis of quinolinic acid in human macrophages. Sulfur 43-44 interferon gamma Homo sapiens 86-102 9871640-2 1998 The most potent of these, 2-amino-5-methyl-S-phenyl cysteine S,S-dioxide 6d, inhibits interferon-gamma induced synthesis of quinolinic acid in human macrophages. Quinolinic Acid 124-139 interferon gamma Homo sapiens 86-102 9537674-4 1998 RESULTS: There was a significant inhibition by dexamethasone (from 1 to 100 nM) on the secretion of monokines (IL-1beta, IL-6, IL-8 and TNF alpha) and lymphokines (IL-2, IL-4, IL-10 and IFN gamma), either after LPS or PHA stimulation (P < 0.01). Dexamethasone 47-60 interferon gamma Homo sapiens 186-195 9799968-7 1998 The RMFI in cells treated with IFN-gamma 0, 0.2 and 5 ng/ml were 5.4 +/- 0.3, 8.2 +/- 0.4, and 24.9 +/- 1.5, respectively; whereas the RMFI in cells co-incubated with VGH-CS-ME-82 (40 micrograms/ml) and IFN-gamma 0, 0.2 ng/ml and 5 ng/ml were 6.7 +/- 0.2 (p < 0.05), 9.2 +/- 0.9 (p < 0.1) and 29.5 +/- 1.2 (p < 0.005), respectively. Cesium 171-173 interferon gamma Homo sapiens 31-40 9799968-8 1998 We conclude that VGH-CS-ME-82, either alone or with IFN-gamma induction, increases the MHC class II antigen expression on hepatoma cell line HA22T/VGH, which will shed light into the present immunotherapy, and make the host immune surveillance more effective against tumor cells with down-regulated MHC class II antigen expression. Cesium 21-23 interferon gamma Homo sapiens 52-61 9448049-6 1998 IL-8 release induced by TNF-alpha and IFN-gamma was partly inhibited by the Th-2-derived cytokines IL-4, IL-10, and IL-13, as well as by dexamethasone. Dexamethasone 137-150 interferon gamma Homo sapiens 38-47 9522499-7 1998 In other hand when the parasites number is reduced or eliminated by Mebendazole, is reduced too the neuropeptides concentration and diminish the blocked of IFN gamma excretion, in this form we can to explain the infection resistance in the ages that are reported. Mebendazole 68-79 interferon gamma Homo sapiens 156-165 9433869-5 1998 In vitro, under the action of MTX, IL-10 gene expression was significantly increased in the 3 groups, IL-4 gene expression was significantly increased in RA group 1 and in the control group, and IL-2 and IFNgamma gene expression was significantly decreased in RA group 1. Methotrexate 30-33 interferon gamma Homo sapiens 204-212 9445252-5 1998 The present study was designed to determine whether the cytokines tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (INF-gamma), and interleukin-1beta (IL-1beta) stimulate tetrahydrobiopterin synthesis by increasing expression of GTP cyclohydrolase I mRNA in endothelial cells. sapropterin 180-199 interferon gamma Homo sapiens 107-123 9445252-5 1998 The present study was designed to determine whether the cytokines tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (INF-gamma), and interleukin-1beta (IL-1beta) stimulate tetrahydrobiopterin synthesis by increasing expression of GTP cyclohydrolase I mRNA in endothelial cells. sapropterin 180-199 interferon gamma Homo sapiens 125-134 9828078-2 1998 It has been shown previously that IFN-gamma induces increased CB activity in phorbol myristate acetate (PMA)-primed THP-1 cells. Tetradecanoylphorbol Acetate 77-102 interferon gamma Homo sapiens 34-43 9828078-2 1998 It has been shown previously that IFN-gamma induces increased CB activity in phorbol myristate acetate (PMA)-primed THP-1 cells. Tetradecanoylphorbol Acetate 104-107 interferon gamma Homo sapiens 34-43 9472658-6 1998 The cytokine secretion profile of restimulated immune lymphoid cells showed that UBX raised IL-2 and interferon-gamma levels and decreased IL-4 production. ubenimex 81-84 interferon gamma Homo sapiens 101-117 9537772-3 1998 OBJECTIVES: Cetirizine and hydrocortisone were compared in their capacity to counteract human keratinocytes activation by IFNgamma. Cetirizine 12-22 interferon gamma Homo sapiens 122-130 9537772-3 1998 OBJECTIVES: Cetirizine and hydrocortisone were compared in their capacity to counteract human keratinocytes activation by IFNgamma. Hydrocortisone 27-41 interferon gamma Homo sapiens 122-130 9537772-6 1998 RESULTS: Cetirizine at high concentrations (10(2)-10(3) microM) markedly inhibited IFNgamma-induced expression of membrane ICAM-1, HLA-DR and up-regulation of MHC class I, but had no effect on CD40 expression. Cetirizine 9-19 interferon gamma Homo sapiens 83-91 9537772-7 1998 In contrast, hydrocortisone (10(2) microM) enhanced IFNgamma-induced membrane ICAM-1, reduced expression of HLA-DR and did not alter expression of MHC class I and CD40. Hydrocortisone 13-27 interferon gamma Homo sapiens 52-60 9537772-8 1998 Consistently, high doses of cetirizine decreased, whereas hydrocortisone increased, soluble ICAM-1 levels in the supernatants of IFNgamma-treated keratinocytes. Cetirizine 28-38 interferon gamma Homo sapiens 129-137 9537772-8 1998 Consistently, high doses of cetirizine decreased, whereas hydrocortisone increased, soluble ICAM-1 levels in the supernatants of IFNgamma-treated keratinocytes. Hydrocortisone 58-72 interferon gamma Homo sapiens 129-137 9537772-10 1998 Finally, cetirizine, but not hydrocortisone, inhibited the release of MCP-1 and RANTES from IFNgamma-stimulated keratinocytes. Cetirizine 9-19 interferon gamma Homo sapiens 92-100 9537772-12 1998 CONCLUSIONS: The results indicate that cetirizine has the capacity to block the IFNgamma-induced activation of keratinocytes, and thus can exert important regulatory effects on TH1 cell-mediated immune responses in the skin. Cetirizine 39-49 interferon gamma Homo sapiens 80-88 9649687-0 1998 The antipsoriatic dimethyl-fumarate suppresses interferon-gamma -induced ICAM-1 and HLA-DR expression on hyperproliferative keratinocytes. Dimethyl Fumarate 18-35 interferon gamma Homo sapiens 47-63 9649687-3 1998 The study focused on the effect of fumaric acid, dimethyl-fumarate, Zn-, Ca- and Mg-monoethyl-fumarate on the interferon-gamma (IFN-gamma)-induced expression of ICAM-1 and HLA-DR molecules on keratinocytes. fumaric acid 35-47 interferon gamma Homo sapiens 110-137 9649687-3 1998 The study focused on the effect of fumaric acid, dimethyl-fumarate, Zn-, Ca- and Mg-monoethyl-fumarate on the interferon-gamma (IFN-gamma)-induced expression of ICAM-1 and HLA-DR molecules on keratinocytes. Dimethyl Fumarate 49-66 interferon gamma Homo sapiens 110-137 9649687-3 1998 The study focused on the effect of fumaric acid, dimethyl-fumarate, Zn-, Ca- and Mg-monoethyl-fumarate on the interferon-gamma (IFN-gamma)-induced expression of ICAM-1 and HLA-DR molecules on keratinocytes. Zinc 68-70 interferon gamma Homo sapiens 110-137 9649687-3 1998 The study focused on the effect of fumaric acid, dimethyl-fumarate, Zn-, Ca- and Mg-monoethyl-fumarate on the interferon-gamma (IFN-gamma)-induced expression of ICAM-1 and HLA-DR molecules on keratinocytes. mg-monoethyl-fumarate 81-102 interferon gamma Homo sapiens 110-137 9734347-8 1998 The significant increase in ICAM-1 expression on HBECs induced by rh IFN-gamma was inhibited, in a dose-dependent manner, by the two drugs, but fenoterol was more efficient than dexamethasone at all of the concentrations tested (p < 0.05, all comparisons). Fenoterol 144-153 interferon gamma Homo sapiens 69-78 9734347-8 1998 The significant increase in ICAM-1 expression on HBECs induced by rh IFN-gamma was inhibited, in a dose-dependent manner, by the two drugs, but fenoterol was more efficient than dexamethasone at all of the concentrations tested (p < 0.05, all comparisons). Dexamethasone 178-191 interferon gamma Homo sapiens 69-78 9397161-5 1998 IFN-alpha and IFN-beta were as effective as IFN-gamma in RPMI-8226 cells, but less than IFN-gamma in KG-1 cells. rpmi 57-61 interferon gamma Homo sapiens 44-53 9397161-10 1998 The effect of IFN-gamma in KG-1 cells was synergistic with that of PMA. Tetradecanoylphorbol Acetate 67-70 interferon gamma Homo sapiens 14-23 10195234-7 1998 In U937 cells, TNF-alpha and phorbol myristate acetate (PMA) stimulated CXCR4 gene transcription; this effect was reversed with prior treatment of cells with IFN-gamma. Tetradecanoylphorbol Acetate 29-54 interferon gamma Homo sapiens 158-167 9814725-8 1998 Interestingly, in PMA + ionomycin stimulated cultures, the atopic cytokine profile was different with more IL-5 (P = 0.0068) and less IFN-gamma production (P = 0.00046) than the control group. Ionomycin 24-33 interferon gamma Homo sapiens 134-143 9541457-4 1998 When HUVSMC were activated by individual inflammatory stimuli (IL-1beta, TNFalpha, IFNgamma or LPS), both intra- and extracellular levels of BH4 increased significantly, with TNFalpha being the most potent single stimulus. sapropterin 141-144 interferon gamma Homo sapiens 83-91 9754910-4 1998 The ability of IFNgamma to stimulate increased bradykinin receptor expression was abrogated by treatment with either the transcription inhibitor actinomycin D or the protein synthesis inhibitor cycloheximide. Dactinomycin 145-158 interferon gamma Homo sapiens 15-23 9424083-8 1998 Furthermore, this subset of T cells proliferated and secreted interferon-gamma, but not interleukin-4, when restimulated in vitro with dinitrochlorobenzene-derivatized fresh peripheral blood mononuclear cells. Dinitrochlorobenzene 135-155 interferon gamma Homo sapiens 62-78 10195234-7 1998 In U937 cells, TNF-alpha and phorbol myristate acetate (PMA) stimulated CXCR4 gene transcription; this effect was reversed with prior treatment of cells with IFN-gamma. Tetradecanoylphorbol Acetate 56-59 interferon gamma Homo sapiens 158-167 9754910-4 1998 The ability of IFNgamma to stimulate increased bradykinin receptor expression was abrogated by treatment with either the transcription inhibitor actinomycin D or the protein synthesis inhibitor cycloheximide. Cycloheximide 194-207 interferon gamma Homo sapiens 15-23 9754910-6 1998 B2 bradykinin receptor mRNA expression was increased as early as 1 h following IFNgamma stimulation, and continued to accumulate for 24 h. Bradykinin-stimulated intracellular calcium mobilization was also increased in IFNgamma-treated T24 cells compared to controls. Calcium 175-182 interferon gamma Homo sapiens 218-226 9422392-3 1998 Exposure of astrocytes in culture to interferon-gamma plus lipopolysaccharide results in stimulation of nitric oxide release. Nitric Oxide 104-116 interferon gamma Homo sapiens 37-53 9597476-0 1998 [Effect of roxithromycin treatment on the IL-4, IL-5, and IFN-gamma production system induced by mite antigen]. Roxithromycin 11-24 interferon gamma Homo sapiens 58-67 9597486-0 1998 [Effect of clarithromycin administration on interferon-gamma and interleukin 12 mRNA expression in the tumor tissue of non-small-cell lung cancer]. Clarithromycin 11-25 interferon gamma Homo sapiens 44-60 9825772-8 1998 The expression of ICAM-1 on SK-N-MC was up-regulated by TNF alpha or IFN gamma, while IL-1alpha also upregulated ICAM-1 on SK-N-SH cells. sk-n-mc 28-35 interferon gamma Homo sapiens 69-78 9865458-9 1998 These results suggest that the Su-PS skin test could predict OK-432-induced natural killer cell activity and IFN-gamma production in patients with gastric cancer, and was therefore useful to determine whether patients were responders to OK-432. su-ps 31-36 interferon gamma Homo sapiens 109-118 9683262-4 1998 After stimulation via TCR, CD4+ T cells produced IFN-gamma and the CpG dinucleotide contained within the TATA proximal regulatory element of the IFN-gamma gene was partially hypomethylated. cytidylyl-3'-5'-guanosine 67-83 interferon gamma Homo sapiens 145-154 9685529-1 1998 Neopterin is produced and released by human macrophages in response to stimulation with interferon-gamma and changes in neopterin concentrations indicate cellular immune activation. Neopterin 0-9 interferon gamma Homo sapiens 88-104 9683262-0 1998 IL-4 and prostaglandin E2 inhibit hypomethylation of the 5" regulatory region of IFN-gamma gene during differentiation of naive CD4+ T cells. Dinoprostone 9-25 interferon gamma Homo sapiens 81-90 9683262-1 1998 We have previously shown that prostaglandin E2 (PGE2) and IL-4 inhibit the priming of IFN-gamma-production during the differentiation of naive CD4+ T cells from human cord blood by different signal-transducing mechanisms. Dinoprostone 30-46 interferon gamma Homo sapiens 86-95 9683262-5 1998 Both IL-4 and PGE2 inhibited the hypomethylation of this site and the acquisition of IFN-gamma-producing ability. Dinoprostone 14-18 interferon gamma Homo sapiens 85-94 9683262-1 1998 We have previously shown that prostaglandin E2 (PGE2) and IL-4 inhibit the priming of IFN-gamma-production during the differentiation of naive CD4+ T cells from human cord blood by different signal-transducing mechanisms. Dinoprostone 48-52 interferon gamma Homo sapiens 86-95 9683262-7 1998 5-azacytidine restored the IFN-gamma-producing ability of these cells treated with IL-4 and PGE2. Azacitidine 0-13 interferon gamma Homo sapiens 27-36 9683262-2 1998 To compare and analyse the molecular mechanisms by which PGE2 and IL-4 inhibit the priming of IFN-gamma production, we investigated the effects of PGE2 and IL-4 on the methylation of the IFN-gamma gene during the in vitro differentiation of naive CD4+ T cells. Dinoprostone 57-61 interferon gamma Homo sapiens 94-103 9683262-7 1998 5-azacytidine restored the IFN-gamma-producing ability of these cells treated with IL-4 and PGE2. Dinoprostone 92-96 interferon gamma Homo sapiens 27-36 9570357-4 1997 Our previous work has shown that RA works synergistically with other agents, such as interferon-gamma (IFN-gamma), to down-regulate N-myc expression and induce differentiation. Tretinoin 33-35 interferon gamma Homo sapiens 85-101 9570357-4 1997 Our previous work has shown that RA works synergistically with other agents, such as interferon-gamma (IFN-gamma), to down-regulate N-myc expression and induce differentiation. Tretinoin 33-35 interferon gamma Homo sapiens 103-112 9550432-4 1997 Increased IFN-gamma production was demonstrated in anti-CD2-stimulated LPMC cultured in TNF-alpha. lpmc 71-75 interferon gamma Homo sapiens 10-19 9416887-6 1997 Inhibition of TF induction in the presence of high CsA blood concentrations was also observed when stimulation of cells was performed with interferon-gamma or interleukin-1beta. Cyclosporine 51-54 interferon gamma Homo sapiens 139-155 9550426-10 1997 However, suppression of IL-1R gene expression by IFN-gamma and IL-10 was associated with decreased tyrosine phosphorylation and nuclear translocation of the IL-4/IL-13-inducible transcription factor, Stat6, suggesting a potential mechanism by which IFN-gamma and IL-10 may mediate their suppressive effects. Tyrosine 99-107 interferon gamma Homo sapiens 49-58 9550432-6 1997 In all four patients who demonstrated clinical and endoscopic improvement, decreased numbers of LPMC producing IFN-gamma and TNF-alpha following CD2/CD28 activation paralleled improvement in disease activity over 8 wk. lpmc 96-100 interferon gamma Homo sapiens 111-120 9550432-7 1997 In one patient who did not improve, increased numbers of TNF-alpha- and IFN-gamma-secreting LPMC were observed. lpmc 92-96 interferon gamma Homo sapiens 72-81 9405230-0 1997 Peroxynitrite protects RAW 264.7 macrophage from Lipopolysaccharide/Interferon-gamma-induced cell death. Peroxynitrous Acid 0-13 interferon gamma Homo sapiens 68-84 9405230-6 1997 Exogenous peroxynitrite (30-50 microM), applied to RAW cells before cytokine stimulation, dramatically reduced LPS/IFN-gamma toxicity. Peroxynitrous Acid 10-23 interferon gamma Homo sapiens 115-124 9405230-7 1997 Measurement of cell viability after overnight incubation with a mixture of LPS (10 microg/ml) and IFN-gamma (100 U/ml), showed that pretreatment with 40 microM peroxynitrite completely reverted LPS/IFN-gamma cytotoxicity. Peroxynitrous Acid 160-173 interferon gamma Homo sapiens 98-107 9405230-7 1997 Measurement of cell viability after overnight incubation with a mixture of LPS (10 microg/ml) and IFN-gamma (100 U/ml), showed that pretreatment with 40 microM peroxynitrite completely reverted LPS/IFN-gamma cytotoxicity. Peroxynitrous Acid 160-173 interferon gamma Homo sapiens 198-207 9401054-1 1997 Induction of nitric oxide synthase (iNOS) and production of the toxic metabolite nitric oxide (NO) is one of the interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) regulated effector mechanisms that can lead to apoptosis of haemopoietic progenitor cells. Nitric Oxide 13-25 interferon gamma Homo sapiens 113-129 9401054-1 1997 Induction of nitric oxide synthase (iNOS) and production of the toxic metabolite nitric oxide (NO) is one of the interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) regulated effector mechanisms that can lead to apoptosis of haemopoietic progenitor cells. Nitric Oxide 13-25 interferon gamma Homo sapiens 131-140 16465284-9 1997 Treatment with IFN-gamma+TNF induced GI-LI-N cells to show only a late and remarkable increase of alpha1/beta1 heterodimer; on the contrary, RA treatment caused a decrease in all integrin chains. Tretinoin 141-143 interferon gamma Homo sapiens 15-24 9409644-7 1997 In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period. phorbol 12-myristate acetate 116-144 interferon gamma Homo sapiens 36-52 9409644-7 1997 In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period. phorbol 12-myristate acetate 116-144 interferon gamma Homo sapiens 54-63 9665005-6 1998 IFN-gamma production by CD4+ T cells showed a negative correlation with the prednisolone dose (P = 0.0175) and, for the CD8+ subset, with CSA trough levels (P = 0.0023). Prednisolone 76-88 interferon gamma Homo sapiens 0-9 9409644-7 1997 In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period. Tetradecanoylphorbol Acetate 146-149 interferon gamma Homo sapiens 36-52 9409644-7 1997 In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period. Ionomycin 151-160 interferon gamma Homo sapiens 36-52 9409644-7 1997 In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period. Tetradecanoylphorbol Acetate 146-149 interferon gamma Homo sapiens 54-63 9409644-7 1997 In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period. Ionomycin 151-160 interferon gamma Homo sapiens 54-63 9384585-1 1997 In response to interferon-gamma (IFN-gamma), Stat1 is tyrosine phosphorylated and translocates to the nucleus where it activates transcription. Tyrosine 54-62 interferon gamma Homo sapiens 15-31 9389514-11 1997 NMMA, when cocultured with IL-1beta + IFNgamma, completely prevents cytokine-induced inhibition of human islet aconitase activity. omega-N-Methylarginine 0-4 interferon gamma Homo sapiens 38-46 9389514-12 1997 NMMA, when added to human islets pretreated for 18 h with IL-1beta + IFNgamma, stimulates the recovery of mitochondrial aconitase activity after an additional 8 h incubation. omega-N-Methylarginine 0-4 interferon gamma Homo sapiens 69-77 9466314-6 1997 TCL initiated with rBet v 1/SL showed significantly increased IFN-gamma production as compared to rBet v 1 -selected TCL. Triclosan 0-3 interferon gamma Homo sapiens 62-71 23100907-4 1997 TH1 cells produce the cytokines interferon-gamma and interleukin-2, which are important for activation of antimycobacterial activities and essential for the DTH response. D-threonine 157-160 interferon gamma Homo sapiens 32-48 9503684-5 1997 Furthermore, the frequency of T cells which produced IL-4, IL-5 and IFN-gamma stimulated with phorbol myristate acetate and ionomycin increased and reduced in parallel with MFI of EG2-positive cells. Tetradecanoylphorbol Acetate 94-119 interferon gamma Homo sapiens 68-77 9503684-5 1997 Furthermore, the frequency of T cells which produced IL-4, IL-5 and IFN-gamma stimulated with phorbol myristate acetate and ionomycin increased and reduced in parallel with MFI of EG2-positive cells. Ionomycin 124-133 interferon gamma Homo sapiens 68-77 9464843-4 1997 PGE2 primes naive T cells in a dose-dependent fashion for production of high levels of IL-4, IL-10 and IL-13, and very low levels of IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and TNF-beta. Dinoprostone 0-4 interferon gamma Homo sapiens 139-161 9464843-5 1997 PGE2 does not significantly increase IL-4 production in priming cultures, whereas it suppresses IL-2 and IFN-gamma. Dinoprostone 0-4 interferon gamma Homo sapiens 105-114 9464798-9 1997 Production of IFN-gamma was significantly induced by addition of PGE2, while no effect on production of IL-4 or IL-10 was observed. Dinoprostone 65-69 interferon gamma Homo sapiens 14-23 9464798-12 1997 Addition of PGE2 again only further polarized this pattern enhancing IFN-gamma production by alloreactive CD8+ T cells in both cultures without inducing type 2 cytokines. Dinoprostone 12-16 interferon gamma Homo sapiens 69-78 9464798-14 1997 TNF-alpha/IL-1, IL-6 + PGE2-cultured DC seem to be optimal for generation of IFN-gamma-producing CD4/CD8+ T cells. Dinoprostone 23-27 interferon gamma Homo sapiens 77-86 9384585-1 1997 In response to interferon-gamma (IFN-gamma), Stat1 is tyrosine phosphorylated and translocates to the nucleus where it activates transcription. Tyrosine 54-62 interferon gamma Homo sapiens 33-42 9384585-3 1997 Tyrosine-phosphorylated Stat1 associated with the beta subunit (a 97 kDa component) of the nuclear pore-targeting complex via the NPI-1 family, but not the Rch1 family, of alpha subunit (a 58 kDa component) as a result of IFN-gamma stimulation. Tyrosine 0-8 interferon gamma Homo sapiens 222-231 9389728-4 1997 Impaired response to IFN-gamma was documented in B cells by signal transducer and activator of transcription 1 nuclear translocation, in fibroblasts by cell surface HLA class II induction, and in monocytes by cell surface CD64 induction and TNF-alpha secretion. hla class ii 165-177 interferon gamma Homo sapiens 21-30 9453454-1 1997 A long-term pretreatment (72 h) of bovine adrenal chromaffin cells with recombinant human interferon (IFN) -alpha-2b (1500 units/ml) produced a decrease in the secretion of catecholamines from the cells stimulated by acetylcholine (ACh) (25 micromol/l) but not that with human fibloblast IFN-beta (3000 units/ml) or recombinant human IFN-gamma (3000 units/ml). chromaffin 50-60 interferon gamma Homo sapiens 334-343 9414136-11 1997 However, when monocytes activated by lipopolysaccharide and IFN-gamma were used instead of neutrophils, endothelial cells were likewise injured, but a much higher level of NO was detected and injury was diminished by addition of carboxy-PTIO to the medium. 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole 229-241 interferon gamma Homo sapiens 60-69 9400826-8 1997 Like IFN-gamma-induced Ia expression, PAF activity was inhibited by prostaglandin E2 (PGE2). Dinoprostone 86-90 interferon gamma Homo sapiens 5-14 9453454-1 1997 A long-term pretreatment (72 h) of bovine adrenal chromaffin cells with recombinant human interferon (IFN) -alpha-2b (1500 units/ml) produced a decrease in the secretion of catecholamines from the cells stimulated by acetylcholine (ACh) (25 micromol/l) but not that with human fibloblast IFN-beta (3000 units/ml) or recombinant human IFN-gamma (3000 units/ml). Catecholamines 173-187 interferon gamma Homo sapiens 334-343 9420627-1 1997 The expression of the major histocompatibility complex (MHC) class I antigens is suppressed in early post-implantation embryonic cells as well as in embryonal carcinoma (EC) cells, but could be upregulated by treatment with interferon (IFN)-gamma or retinoic acid. Tretinoin 250-263 interferon gamma Homo sapiens 224-246 9374532-2 1997 Along with other cytokines, IFN-gamma gene expression is inhibited by the immunosuppressant cyclosporin A. Cyclosporine 92-105 interferon gamma Homo sapiens 28-37 18642238-0 1997 Influence of Primatone RL supplementation on sialylation of recombinant human interferon-gamma produced by Chinese hamster ovary cell culture using serum-free media. primatone 13-22 interferon gamma Homo sapiens 78-94 9388501-7 1997 Inhibitors of NO, L-NG-monomethyl L-arginine, and aminoguanidine partially restored cell proliferation and collagen synthesis in cells exposed to LPS and IFN gamma. l-ng-monomethyl l-arginine 18-44 interferon gamma Homo sapiens 154-163 9388501-7 1997 Inhibitors of NO, L-NG-monomethyl L-arginine, and aminoguanidine partially restored cell proliferation and collagen synthesis in cells exposed to LPS and IFN gamma. pimagedine 50-64 interferon gamma Homo sapiens 154-163 9432636-6 1997 It was found that pentoxifylline (Ptx) was able to inhibit significantly the HLA-DR expression and glycosaminoglycan synthesis induced by inflammatory cytokines including TNF-alpha, IFN-gamma and IL-1. Pentoxifylline 18-32 interferon gamma Homo sapiens 182-191 9432636-6 1997 It was found that pentoxifylline (Ptx) was able to inhibit significantly the HLA-DR expression and glycosaminoglycan synthesis induced by inflammatory cytokines including TNF-alpha, IFN-gamma and IL-1. Pentoxifylline 34-37 interferon gamma Homo sapiens 182-191 9388485-5 1997 These results suggest that 5-FU has the capacity to induce apoptosis in COLO 201, resulting from the up-regulation of Bax; the apoptosis-inducing signal of 5-FU seems to be different from that of IFN-gamma. Fluorouracil 27-31 interferon gamma Homo sapiens 196-205 9374532-3 1997 We have previously identified an intronic enhancer region (C3) of the IFN-gamma gene that binds the NF-kappaB protein c-Rel and that shows partial DNA sequence homology with the cyclosporin A-sensitive NFAT binding site and the 3"-half of the NF-kappaB consensus site. Cyclosporine 178-191 interferon gamma Homo sapiens 70-79 9374532-9 1997 Site-directed mutagenesis and transfection studies demonstrate that calcineurin-inducible transcriptional factors enhance the transcriptional activity of the IFN-gamma promoter through the cyclosporin-sensitive C3-3P site, whereas NF-kappaB proteins functionally interact with the C3-related sites. Cyclosporine 189-200 interferon gamma Homo sapiens 158-167 9359732-2 1997 CNI-1493 inhibited lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-6, and IL-8 production whether or not LPS stimulation was enhanced by interferon (IFN)-gamma priming. semapimod 0-8 interferon gamma Homo sapiens 195-217 9348307-1 1997 Although researchers have noted high level activation of rodent mononuclear phagocytes for nitric oxide (NO) synthase type 2 (S2) expression and NO production with a variety of agents such as interferon (IFN) gamma and endotoxin, it has been difficult to demonstrate activation of human mononuclear phagocytes. Nitric Oxide 91-103 interferon gamma Homo sapiens 192-214 9372655-5 1997 Cells retrieved from the saline-challenged segment secreted principally interferon-gamma (IFN-gamma) and IL-2. Sodium Chloride 25-31 interferon gamma Homo sapiens 72-88 9372655-5 1997 Cells retrieved from the saline-challenged segment secreted principally interferon-gamma (IFN-gamma) and IL-2. Sodium Chloride 25-31 interferon gamma Homo sapiens 90-99 9420133-2 1997 In vitro studies using the technique of cloning lymphocytes demonstrated that a great proportion of T-cell clones derived from bronchial mucosa of subjects with TDI-induced asthma produced IL-5 and interferon-gamma, but not IL-4, upon in vitro stimulation. Toluene 2,4-Diisocyanate 161-164 interferon gamma Homo sapiens 198-214 9374718-0 1997 Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-gamma and Fas. Dexamethasone 0-13 interferon gamma Homo sapiens 65-74 9374718-5 1997 Interestingly, the corticosteroid dexamethasone was the most potent inhibitor of IFN-gamma- and IFN-gamma plus anti-Fas-induced apoptosis. Dexamethasone 34-47 interferon gamma Homo sapiens 81-90 9374718-5 1997 Interestingly, the corticosteroid dexamethasone was the most potent inhibitor of IFN-gamma- and IFN-gamma plus anti-Fas-induced apoptosis. Dexamethasone 34-47 interferon gamma Homo sapiens 96-105 9359732-6 1997 Phorbol ester and ionomycin activation also resulted in a CNI-1493 -induced inhibition of TNF-alpha in monocytes but resistant production of TNF-alpha, IL-2, and IFN-gamma by T cells. Phorbol Esters 0-13 interferon gamma Homo sapiens 162-171 9359732-6 1997 Phorbol ester and ionomycin activation also resulted in a CNI-1493 -induced inhibition of TNF-alpha in monocytes but resistant production of TNF-alpha, IL-2, and IFN-gamma by T cells. Ionomycin 18-27 interferon gamma Homo sapiens 162-171 9402108-3 1997 In this study, we demonstrate that IFN-gamma induces structural changes in the cell membrane by altering the cholesterol/phospholipid ratio. Cholesterol 109-120 interferon gamma Homo sapiens 35-44 9402108-3 1997 In this study, we demonstrate that IFN-gamma induces structural changes in the cell membrane by altering the cholesterol/phospholipid ratio. Phospholipids 121-133 interferon gamma Homo sapiens 35-44 9343425-1 1997 Gamma interferon (IFN-gamma) induces both tyrosine and serine phosphorylation of Stat1. Tyrosine 42-50 interferon gamma Homo sapiens 0-27 9363902-1 1997 BACKGROUND: In various cells including monocytes the cytokine interferon-gamma as well as lipopolysaccharide induce indoleamine 2,3-dioxygenase which degrades tryptophan to form L-kynurenine. Tryptophan 159-169 interferon gamma Homo sapiens 62-78 9363902-1 1997 BACKGROUND: In various cells including monocytes the cytokine interferon-gamma as well as lipopolysaccharide induce indoleamine 2,3-dioxygenase which degrades tryptophan to form L-kynurenine. Kynurenine 178-190 interferon gamma Homo sapiens 62-78 9363902-6 1997 In parallel, production of interferon-gamma was found, and the tryptophan degradation could be blocked by antihuman interferon-gamma antibodies. Tryptophan 63-73 interferon gamma Homo sapiens 27-43 9363902-6 1997 In parallel, production of interferon-gamma was found, and the tryptophan degradation could be blocked by antihuman interferon-gamma antibodies. Tryptophan 63-73 interferon gamma Homo sapiens 116-132 9363902-7 1997 Tryptophan degradation was not induced when the human myelocytoma cell line THP-1 was stimulated with these toxins, but there was a costimulatoty effect to interferon-gamma. Tryptophan 0-10 interferon gamma Homo sapiens 156-172 9363902-8 1997 CONCLUSIONS: In peripheral blood mononuclear cell culture streptococcal erythrogenic toxins are able to stimulate tryptophan degradation in humans via the induction of interferon-gamma production. Tryptophan 114-124 interferon gamma Homo sapiens 168-184 9343425-1 1997 Gamma interferon (IFN-gamma) induces both tyrosine and serine phosphorylation of Stat1. Serine 55-61 interferon gamma Homo sapiens 0-27 9343425-7 1997 Finally, a kinase capable of correct Stat1 serine phosphorylation was detected in partially purified cytoplasmic extracts from both IFN-gamma-treated and untreated cells. Serine 43-49 interferon gamma Homo sapiens 132-141 9326637-3 1997 Here, we show that UV light interferes with tyrosine phosphorylation of STAT1, thereby hindering IFNgamma from exerting its biological effects. Tyrosine 44-52 interferon gamma Homo sapiens 97-105 9349671-8 1997 It was also demonstrated that the concentrations of IFN-gamma and MIP-1alpha in the cultures in the presence of prednisolone were apparently decreased, suggesting a possible involvement of these cytokines in the pathogenesis of HAM/TSP. Prednisolone 112-124 interferon gamma Homo sapiens 52-61 21590232-3 1997 LPS and IFN-gamma-induced increases in CB were down-regulated by dexamethasone, an inhibitor of phospholipase A(2) (PLA(2)). Dexamethasone 65-78 interferon gamma Homo sapiens 8-17 21590232-6 1997 These data suggest that arachidonic acid may be associated with part of the intracellular signal pathway in the induction of CB activity by LPS, PMA and IFN-gamma. Arachidonic Acid 24-40 interferon gamma Homo sapiens 153-162 9378988-2 1997 We show in this study that IFN-gamma treatment down-regulates the induction by a viral mimetic, polyinosinic-polycytidylic acid (poly(I:C)), of the endothelial cell-specific leukocyte adhesion protein, E-selectin. Poly I-C 96-127 interferon gamma Homo sapiens 27-36 9378988-3 1997 The inhibitory effect of IFN-gamma on poly(I:C)-induced E-selectin was concentration and time dependent and was specific for dsRNA, in that the induction of E-selectin by TNF-alpha, IL-1 beta, thrombin, or LPS was not inhibited significantly by this pretreatment. Poly I 38-44 interferon gamma Homo sapiens 25-34 9378988-3 1997 The inhibitory effect of IFN-gamma on poly(I:C)-induced E-selectin was concentration and time dependent and was specific for dsRNA, in that the induction of E-selectin by TNF-alpha, IL-1 beta, thrombin, or LPS was not inhibited significantly by this pretreatment. Carbon 45-47 interferon gamma Homo sapiens 25-34 9344500-0 1997 Prostaglandin E2 and IL-4 provide naive CD4+ T cells with distinct inhibitory signals for the priming of IFN-gamma production. Dinoprostone 0-16 interferon gamma Homo sapiens 105-114 9344500-2 1997 The presence of PGE2 or IL-4 at primary stimulation inhibited the production of IFN-gamma at secondary stimulation, and the combination of these stimuli resulted in cooperative effects. Dinoprostone 16-20 interferon gamma Homo sapiens 80-89 9344500-6 1997 Our results suggest that both PGE2 and IL-4 play important roles with distinct mechanisms in inhibiting the priming of IFN-gamma production of naive CD4(+) T cells. Dinoprostone 30-34 interferon gamma Homo sapiens 119-128 9378988-5 1997 Poly(I:C)-induced E-selectin mRNA t1/2 was reduced slightly by IFN-gamma treatment, while the message for VCAM-1 was stabilized. Poly I-C 0-9 interferon gamma Homo sapiens 63-72 9378988-7 1997 Poly(I:C)-induced nuclear factor-kappa B activation following IFN-gamma pretreatment was unaffected, as shown by electrophoretic mobility shift analysis. Poly I-C 0-9 interferon gamma Homo sapiens 62-71 9357766-0 1997 Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma. Thyroxine 44-53 interferon gamma Homo sapiens 79-95 9444384-5 1997 The PKC antagonists (H7, sphingosine) as well as RA downregulated the IFN-gamma-induced PNA-reactive gps, whereas staurosporine and TPA upregulated their expression. Sphingosine 25-36 interferon gamma Homo sapiens 70-79 9444384-5 1997 The PKC antagonists (H7, sphingosine) as well as RA downregulated the IFN-gamma-induced PNA-reactive gps, whereas staurosporine and TPA upregulated their expression. Tretinoin 49-51 interferon gamma Homo sapiens 70-79 9444384-5 1997 The PKC antagonists (H7, sphingosine) as well as RA downregulated the IFN-gamma-induced PNA-reactive gps, whereas staurosporine and TPA upregulated their expression. Tetradecanoylphorbol Acetate 132-135 interferon gamma Homo sapiens 70-79 9357766-3 1997 L-Thyroxine (T4), 3,5,3"-L-triiodothyronine (T3), and milrinone enhanced the antiviral activity of IFN-gamma up to 100-fold, a potentiation blocked by cycloheximide. Thyroxine 0-11 interferon gamma Homo sapiens 99-108 9357766-3 1997 L-Thyroxine (T4), 3,5,3"-L-triiodothyronine (T3), and milrinone enhanced the antiviral activity of IFN-gamma up to 100-fold, a potentiation blocked by cycloheximide. 3,5,3"-l-triiodothyronine 18-43 interferon gamma Homo sapiens 99-108 9357766-3 1997 L-Thyroxine (T4), 3,5,3"-L-triiodothyronine (T3), and milrinone enhanced the antiviral activity of IFN-gamma up to 100-fold, a potentiation blocked by cycloheximide. Triiodothyronine 45-47 interferon gamma Homo sapiens 99-108 9357766-3 1997 L-Thyroxine (T4), 3,5,3"-L-triiodothyronine (T3), and milrinone enhanced the antiviral activity of IFN-gamma up to 100-fold, a potentiation blocked by cycloheximide. Milrinone 54-63 interferon gamma Homo sapiens 99-108 9357766-3 1997 L-Thyroxine (T4), 3,5,3"-L-triiodothyronine (T3), and milrinone enhanced the antiviral activity of IFN-gamma up to 100-fold, a potentiation blocked by cycloheximide. Cycloheximide 151-164 interferon gamma Homo sapiens 99-108 9335378-5 1997 PTEC stimulated with IL-2 exhibited very low binding of digoxigenin-labeled IL-2; however, stimulation of PTEC with IL-2, in combination with interferon (IFN)-gamma, resulted in increased binding of the digoxigenin-labeled IL-2. Digoxigenin 203-214 interferon gamma Homo sapiens 142-164 9334853-2 1997 Naive CD4+CD45RA+ T-cells from human cord blood expressed CDw127 (IL-7R) at higher levels than adult CD4+ CD45RA+ T-cells and produced IL-2 and a small amount of IFN-gamma upon stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 194-197 interferon gamma Homo sapiens 162-171 9312192-5 1997 In CsA-treated leukocytes stimulated by calcium ionophore, the degree of reduction in CN activity was accompanied by a similar degree of inhibition of each event tested: dephosphorylation of nuclear factor of activated T cell proteins, nuclear DNA binding, activation of a transfected reporter gene construct, IFN-gamma and IL-2 mRNA accumulation, and IFN-gamma production. Cyclosporine 3-6 interferon gamma Homo sapiens 310-319 9312192-5 1997 In CsA-treated leukocytes stimulated by calcium ionophore, the degree of reduction in CN activity was accompanied by a similar degree of inhibition of each event tested: dephosphorylation of nuclear factor of activated T cell proteins, nuclear DNA binding, activation of a transfected reporter gene construct, IFN-gamma and IL-2 mRNA accumulation, and IFN-gamma production. Cyclosporine 3-6 interferon gamma Homo sapiens 352-361 9326455-3 1997 We demonstrate that JAK2 and Stat1 are phosphorylated at tyrosine residues in a time- and concentration-dependent manner following exposure to IFN-gamma. Tyrosine 57-65 interferon gamma Homo sapiens 143-152 9415032-5 1997 Flow cytometric analysis revealed that interferon-gamma (IFN-gamma)-induced upregulation of B7-1 expression on monocytes was profoundly inhibited by n-butyrate. Butyrates 149-159 interferon gamma Homo sapiens 39-66 9333181-2 1997 The purpose was to show that IFN-gamma would increase the response to 30 days of Sb treatment and that short-course (15 days) combination therapy was as effective as 30 days of Sb alone. Antimony 81-83 interferon gamma Homo sapiens 29-38 9394194-2 1997 These pro-inflammatory cytokines can generate inducible nitric oxide synthase and cause nitric oxide to be released, as can low concentrations of malarial toxin itself provided interferon-gamma, which has only low activity in the absence of malarial toxin, is present. Nitric Oxide 56-68 interferon gamma Homo sapiens 177-193 9333181-5 1997 These results suggest that the beneficial effects of adjunctive IFN-gamma in visceral leishmaniasis may be limited in regions where this disseminated intracellular infection shows high-level resistance to Sb. Antimony 205-207 interferon gamma Homo sapiens 64-73 9317123-7 1997 EC costimulation of IFN-gamma production is inhibited by cyclosporine. Cyclosporine 57-69 interferon gamma Homo sapiens 20-29 9327364-9 1997 IFN-gamma-positive cells were present in all CD ileal and lymph node specimens, predominantly in close contact with EGCC. egcc 116-120 interferon gamma Homo sapiens 0-9 9355959-0 1997 Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha. Quinolinic Acid 0-15 interferon gamma Homo sapiens 58-67 9355959-2 1997 Recent studies suggest that activation of macrophages with either HIV-1 or interferon-gamma (IFN-gamma) can lead to QUIN production. Quinolinic Acid 116-120 interferon gamma Homo sapiens 93-102 9355959-7 1997 Results at 72 h showed significant increases in QUIN production in the cells stimulated with IFN-gamma (10297 +/- 170 nmol/L) and also in those stimulated with IFN-alpha (3600 +/- 113 nmol/L), whereas TNF-alpha-stimulated macrophages produced low levels of QUIN (1108 +/- 23 nmol/L). Quinolinic Acid 48-52 interferon gamma Homo sapiens 93-102 9355959-7 1997 Results at 72 h showed significant increases in QUIN production in the cells stimulated with IFN-gamma (10297 +/- 170 nmol/L) and also in those stimulated with IFN-alpha (3600 +/- 113 nmol/L), whereas TNF-alpha-stimulated macrophages produced low levels of QUIN (1108 +/- 23 nmol/L). Quinolinic Acid 257-261 interferon gamma Homo sapiens 93-102 9355959-8 1997 Macrophages stimulated with the cytokine combinations TNF-alpha and IFN-gamma, IFN-alpha, and IFN-gamma, and TNF-alpha and IFN-alpha also resulted in increases in QUIN production (11471 +/- 77.6 nmol/L, 16656 +/- 184 nmol/L, and 3369 +/- 120.5 nmol/L, respectively). Quinolinic Acid 163-167 interferon gamma Homo sapiens 68-77 9355959-8 1997 Macrophages stimulated with the cytokine combinations TNF-alpha and IFN-gamma, IFN-alpha, and IFN-gamma, and TNF-alpha and IFN-alpha also resulted in increases in QUIN production (11471 +/- 77.6 nmol/L, 16656 +/- 184 nmol/L, and 3369 +/- 120.5 nmol/L, respectively). Quinolinic Acid 163-167 interferon gamma Homo sapiens 94-103 9355962-8 1997 It was established that AE-22 can induce TNF-alpha, IL-6, and IFN-gamma in a dose-dependent manner in BAL cells and PBL isolated from healthy individuals. NSC639782 24-29 interferon gamma Homo sapiens 62-71 9350283-0 1997 Interferon-gamma enhancement of E-selectin expression on endothelial cells is inhibited by monensin. Monensin 91-99 interferon gamma Homo sapiens 0-16 9350283-3 1997 SDS-PAGE analysis of HUVEC glycoproteins, metabolically radiolabelled in the carbohydrate portion, indicated that addition of IFN-gamma produced an altered protein glycosylation. Sodium Dodecyl Sulfate 0-3 interferon gamma Homo sapiens 126-135 9350283-3 1997 SDS-PAGE analysis of HUVEC glycoproteins, metabolically radiolabelled in the carbohydrate portion, indicated that addition of IFN-gamma produced an altered protein glycosylation. Carbohydrates 77-89 interferon gamma Homo sapiens 126-135 9350283-6 1997 When HUVEC were incubated with monesin, a potent inhibitor of late Golgi function, together with both TNF-alpha and IFN-gamma, the additive effect of IFN-gamma on E-selectin expression was almost abolished. monesin 31-38 interferon gamma Homo sapiens 116-125 9350283-6 1997 When HUVEC were incubated with monesin, a potent inhibitor of late Golgi function, together with both TNF-alpha and IFN-gamma, the additive effect of IFN-gamma on E-selectin expression was almost abolished. monesin 31-38 interferon gamma Homo sapiens 150-159 9369326-2 1997 We have shown previously that beta-amyloid (beta25-35), in combination with interferon-gamma (IFN-gamma), can induce nitric oxide release from cultured hippocampal microglial cells. Nitric Oxide 117-129 interferon gamma Homo sapiens 76-92 9287352-9 1997 Together, the data suggest that SHP-1 is positively involved in EGF- and INF-gamma-induced STAT activation in non-hematopoietic HeLa cells and that, in the EGF signaling system, SHP-1 functions at least partly by modulating tyrosine phosphorylation of EGF receptor. Tyrosine 224-232 interferon gamma Homo sapiens 73-82 9344321-6 1997 In 55 patients treated with the combination of high-dose rTNF alpha + interferon-gamma + melphalan an overall objective response rate of 87% with 36% complete responses was observed; it was 81% and 28%, respectively, in a group treated with TNF alpha and melphalan (n = 85). Melphalan 255-264 interferon gamma Homo sapiens 70-86 9369326-2 1997 We have shown previously that beta-amyloid (beta25-35), in combination with interferon-gamma (IFN-gamma), can induce nitric oxide release from cultured hippocampal microglial cells. Nitric Oxide 117-129 interferon gamma Homo sapiens 94-103 9372267-2 1997 Exposure of lymphocytes to catecholamines at concentrations as low as 10 nM leads to decreased proliferation and differentiation, e.g. interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and immunoglobulin (Ig). Catecholamines 27-41 interferon gamma Homo sapiens 135-151 9298179-5 1997 Budesonide was added at concentrations corresponding to 10(-8), 10(-7), and 10(-6) mol/l in cultured epithelial cells, either in the absence of any stimulus or in the presence of interferon-gamma (IFN-gamma) at 500 U/ml. Budesonide 0-10 interferon gamma Homo sapiens 179-195 9298179-5 1997 Budesonide was added at concentrations corresponding to 10(-8), 10(-7), and 10(-6) mol/l in cultured epithelial cells, either in the absence of any stimulus or in the presence of interferon-gamma (IFN-gamma) at 500 U/ml. Budesonide 0-10 interferon gamma Homo sapiens 197-206 9298179-9 1997 In addition, budesonide reduced surface ICAM-1 upregulation induced by IFN-gamma at 500 U/ml (P < 0.05). Budesonide 13-23 interferon gamma Homo sapiens 71-80 9291104-5 1997 High activities of kynurenine 3-hydroxylase, kynureninase or 3-hydroxyanthranilate 3,4-dioxygenase were found in interferon-gamma-stimulated macrophages, THP-1 cells and SKHEP1 cells, and these cells made large amounts of quinolinate when supplied with L-tryptophan, L-kynurenine, 3-hydroxykynurenine or 3-hydroxyanthranilate. 3-Hydroxyanthranilic Acid 62-82 interferon gamma Homo sapiens 113-129 9291104-5 1997 High activities of kynurenine 3-hydroxylase, kynureninase or 3-hydroxyanthranilate 3,4-dioxygenase were found in interferon-gamma-stimulated macrophages, THP-1 cells and SKHEP1 cells, and these cells made large amounts of quinolinate when supplied with L-tryptophan, L-kynurenine, 3-hydroxykynurenine or 3-hydroxyanthranilate. Quinolinic Acid 222-233 interferon gamma Homo sapiens 113-129 9291104-5 1997 High activities of kynurenine 3-hydroxylase, kynureninase or 3-hydroxyanthranilate 3,4-dioxygenase were found in interferon-gamma-stimulated macrophages, THP-1 cells and SKHEP1 cells, and these cells made large amounts of quinolinate when supplied with L-tryptophan, L-kynurenine, 3-hydroxykynurenine or 3-hydroxyanthranilate. Tryptophan 253-265 interferon gamma Homo sapiens 113-129 9291104-5 1997 High activities of kynurenine 3-hydroxylase, kynureninase or 3-hydroxyanthranilate 3,4-dioxygenase were found in interferon-gamma-stimulated macrophages, THP-1 cells and SKHEP1 cells, and these cells made large amounts of quinolinate when supplied with L-tryptophan, L-kynurenine, 3-hydroxykynurenine or 3-hydroxyanthranilate. Kynurenine 267-279 interferon gamma Homo sapiens 113-129 9291104-5 1997 High activities of kynurenine 3-hydroxylase, kynureninase or 3-hydroxyanthranilate 3,4-dioxygenase were found in interferon-gamma-stimulated macrophages, THP-1 cells and SKHEP1 cells, and these cells made large amounts of quinolinate when supplied with L-tryptophan, L-kynurenine, 3-hydroxykynurenine or 3-hydroxyanthranilate. 3-hydroxykynurenine 281-300 interferon gamma Homo sapiens 113-129 9291104-5 1997 High activities of kynurenine 3-hydroxylase, kynureninase or 3-hydroxyanthranilate 3,4-dioxygenase were found in interferon-gamma-stimulated macrophages, THP-1 cells and SKHEP1 cells, and these cells made large amounts of quinolinate when supplied with L-tryptophan, L-kynurenine, 3-hydroxykynurenine or 3-hydroxyanthranilate. 3-Hydroxyanthranilic Acid 61-82 interferon gamma Homo sapiens 113-129 9389931-3 1997 Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta. Dexamethasone 0-13 interferon gamma Homo sapiens 73-82 9389931-3 1997 Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta. Norepinephrine 18-31 interferon gamma Homo sapiens 73-82 9301660-0 1997 Fused pyrrolo[2,3-c]carbazol-6-ones: novel immunostimulants that enhance human interferon-gamma activity. pyrrolo[2,3-c]carbazol-6-ones 6-35 interferon gamma Homo sapiens 79-95 9372267-2 1997 Exposure of lymphocytes to catecholamines at concentrations as low as 10 nM leads to decreased proliferation and differentiation, e.g. interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and immunoglobulin (Ig). Catecholamines 27-41 interferon gamma Homo sapiens 153-162 9307240-3 1997 Cultured human monocytic THP-1 cells increased their glutamate secretion following 18 and 68 h exposure to the inflammatory mediators zymosan, phorbol myristate acetate (PMA), lipopolysaccharide, interferon-gamma, tumor-necrosis factor-alpha and interleukin-1beta. Glutamic Acid 53-62 interferon gamma Homo sapiens 196-241 9370932-4 1997 This mannan-liposome-mediated activity was greatly inhibited by in vivo injection of anti-interferon (IFN)-gamma antibody, which suggests that IFN-gamma plays an important role in this HIV-specific immune response. Mannans 5-11 interferon gamma Homo sapiens 143-152 9293812-3 1997 METHODS: IFNg was labeled with 123I to produce a specific activity of 1800 MBq/mg of IFNg. Iodine-123 31-35 interferon gamma Homo sapiens 9-13 9293812-3 1997 METHODS: IFNg was labeled with 123I to produce a specific activity of 1800 MBq/mg of IFNg. Iodine-123 31-35 interferon gamma Homo sapiens 85-89 9328251-0 1997 Interferon-gamma induced increases in intracellular calcium in T lymphocytes from patients with multiple sclerosis precede clinical exacerbations and detection of active lesions on MRI. Calcium 52-59 interferon gamma Homo sapiens 0-16 9328251-1 1997 BACKGROUND: Interferon (IFN)-gamma exerts a multiplicity of actions potentially relevant for the pathogenesis of multiple sclerosis, including the expression of a transplasmalemma calcium (Ca2+) influx leading to an intracellular Ca2+ ([Ca2+]i) increase able to lower T lymphocyte threshold of excitability. Calcium 180-187 interferon gamma Homo sapiens 12-34 9637344-10 1997 Pro alpha1 stimulated alone or in combination with IFN-gamma the TNF-alpha and IL-1beta secretion by monocytes and decreased the high PGE2 and TGF-beta level, especially in the patients groups. Dinoprostone 134-138 interferon gamma Homo sapiens 51-60 9637359-6 1997 Both TNF-alpha and IL-10 have been found to be major factors determining enhancing effects of PMEG, (R)-PMPA, and (S)-PMPA on production of NO generated by exogenous IFN-gamma. 9-((2-phosphonylmethoxy)ethyl)guanine 94-98 interferon gamma Homo sapiens 166-175 9637359-6 1997 Both TNF-alpha and IL-10 have been found to be major factors determining enhancing effects of PMEG, (R)-PMPA, and (S)-PMPA on production of NO generated by exogenous IFN-gamma. Tenofovir 100-108 interferon gamma Homo sapiens 166-175 9637359-6 1997 Both TNF-alpha and IL-10 have been found to be major factors determining enhancing effects of PMEG, (R)-PMPA, and (S)-PMPA on production of NO generated by exogenous IFN-gamma. Tenofovir 114-122 interferon gamma Homo sapiens 166-175 9302647-2 1997 Ascorbic acid and some cytokines such as transforming growth factor-beta and interferon-gamma are important regulators of collagen synthesis. Ascorbic Acid 0-13 interferon gamma Homo sapiens 77-93 9302649-6 1997 Proliferation of cultured normal human epidermal keratinocytes was inhibited in the presence of 1,25-dihydroxyvitamin D3 at the concentrations of 1 x 10(-8) to 1 x 10(-6) M and 22-oxacalcitriol at concentrations of more than 1 x 10(-9) M at 48 h. IL-8 secretion from normal human epidermal keratinocytes was augmented by TNF-alpha, or synergistically by TNF-alpha and IFN-gamma. Calcitriol 96-120 interferon gamma Homo sapiens 368-377 9293812-2 1997 This study was undertaken to investigate the dose response of escalating doses of inhaled 123I-labeled IFNg (123I-IFNg) and its safety, biodistribution and radiation absorbed doses in healthy volunteers. Iodine-123 90-94 interferon gamma Homo sapiens 103-107 9293812-2 1997 This study was undertaken to investigate the dose response of escalating doses of inhaled 123I-labeled IFNg (123I-IFNg) and its safety, biodistribution and radiation absorbed doses in healthy volunteers. Iodine-123 90-94 interferon gamma Homo sapiens 114-118 9402691-0 1997 Antigen presentation by endothelium: heparin reduces the immunogenicity of interferon-gamma-treated endothelial cells. Heparin 37-44 interferon gamma Homo sapiens 75-91 9284972-4 1997 IFN-gamma induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophan-nicotinic acid pathway. Tryptophan 67-77 interferon gamma Homo sapiens 0-9 9284972-4 1997 IFN-gamma induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophan-nicotinic acid pathway. Hydrocortisone 105-113 interferon gamma Homo sapiens 0-9 9284972-4 1997 IFN-gamma induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophan-nicotinic acid pathway. Tryptophan 133-143 interferon gamma Homo sapiens 0-9 9284972-4 1997 IFN-gamma induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophan-nicotinic acid pathway. Niacin 220-234 interferon gamma Homo sapiens 0-9 9277444-7 1997 IFN-gamma (300 U/ml), TNF-alpha (20 ng/ml), and IL-1 alpha (20 ng/ml) all induced a significantly increased release of prelabeled [3H]AA after 15 min to 2 h of treatment in control cells, and their effects were significantly reduced in cells transfected with cPLA2 antisense vector. Tritium 131-133 interferon gamma Homo sapiens 0-9 9241043-5 1997 IFNgamma production in vitro was significantly decreased by decidual cells prepared from decidua collected after labor as compared with those collected before the commencement of labor, a change that may be associated with prostaglandin E2 (PGE2) production in conjunction with labor. Dinoprostone 223-239 interferon gamma Homo sapiens 0-8 9241043-5 1997 IFNgamma production in vitro was significantly decreased by decidual cells prepared from decidua collected after labor as compared with those collected before the commencement of labor, a change that may be associated with prostaglandin E2 (PGE2) production in conjunction with labor. Dinoprostone 241-245 interferon gamma Homo sapiens 0-8 9242526-7 1997 However, the kinetics of Stat1-phosphate decay in IFN-gamma-treated cells was prolonged in mutant cells and was normalized by transduction of the normal FAC gene. Phosphates 31-40 interferon gamma Homo sapiens 50-59 9245541-5 1997 An increase in IL-2 production may be a part of this mechanism since addition of serotonin to in vitro cultures of PHA-stimulated cells increases the expression of mRNA for IL-2 and IFN-gamma. Serotonin 81-90 interferon gamma Homo sapiens 182-191 9276525-7 1997 Patients with mild disease showing high inducibility of IFN-gamma mRNA in their PBMC not only had the highest frequency of responders, but also the highest extent of an individual response, defined by superinduction of mRNA, to agents that relieve suppression (gamma-irradiation) or post-transcriptional down-regulation (cycloheximide). Cycloheximide 321-334 interferon gamma Homo sapiens 56-65 9269868-1 1997 A long-acting depot formulation of recombinant human interferon-gamma (rhIFN-gamma) was achieved by microencapsulation of rhIFN-gamma in polylactic-coglycolic acid (PLGA) microspheres by a water-in-oil-in-water technique. rhifn- 71-77 interferon gamma Homo sapiens 53-69 9292066-5 1997 There was a significant increase in the mRNA expression for interferon-gamma (IFN-gamma), interleukin (IL)-2 and IL-4 together after nickel challenge in both patients (analysis of variance P = 0.007) and non-atopic-individuals (P = 0.005). Nickel 133-139 interferon gamma Homo sapiens 60-76 9292066-5 1997 There was a significant increase in the mRNA expression for interferon-gamma (IFN-gamma), interleukin (IL)-2 and IL-4 together after nickel challenge in both patients (analysis of variance P = 0.007) and non-atopic-individuals (P = 0.005). Nickel 133-139 interferon gamma Homo sapiens 78-87 9285245-6 1997 In response to IFN-gamma-priming and taxol triggering, TBH M phi s increase their production of NO as compared to resting M phi s; however, unlike normal host M phi s, taxol-induced TBH M phi NO production was significantly suboptimal. Paclitaxel 168-173 interferon gamma Homo sapiens 15-24 9285245-6 1997 In response to IFN-gamma-priming and taxol triggering, TBH M phi s increase their production of NO as compared to resting M phi s; however, unlike normal host M phi s, taxol-induced TBH M phi NO production was significantly suboptimal. tbh 55-58 interferon gamma Homo sapiens 15-24 9285246-7 1997 The in vitro effect of haloperidol and clozapine on PHA stimulation of lymphocytes from normal subjects was determined by 3H-thymidine uptake and secretion of interleukin-2, interleukin-4 and interferon-gamma. Haloperidol 23-34 interferon gamma Homo sapiens 192-208 9285246-7 1997 The in vitro effect of haloperidol and clozapine on PHA stimulation of lymphocytes from normal subjects was determined by 3H-thymidine uptake and secretion of interleukin-2, interleukin-4 and interferon-gamma. Clozapine 39-48 interferon gamma Homo sapiens 192-208 9269868-1 1997 A long-acting depot formulation of recombinant human interferon-gamma (rhIFN-gamma) was achieved by microencapsulation of rhIFN-gamma in polylactic-coglycolic acid (PLGA) microspheres by a water-in-oil-in-water technique. Polylactic Acid-Polyglycolic Acid Copolymer 137-163 interferon gamma Homo sapiens 53-69 9269868-1 1997 A long-acting depot formulation of recombinant human interferon-gamma (rhIFN-gamma) was achieved by microencapsulation of rhIFN-gamma in polylactic-coglycolic acid (PLGA) microspheres by a water-in-oil-in-water technique. Water 189-194 interferon gamma Homo sapiens 53-69 9269868-1 1997 A long-acting depot formulation of recombinant human interferon-gamma (rhIFN-gamma) was achieved by microencapsulation of rhIFN-gamma in polylactic-coglycolic acid (PLGA) microspheres by a water-in-oil-in-water technique. Oils 198-201 interferon gamma Homo sapiens 53-69 9269868-1 1997 A long-acting depot formulation of recombinant human interferon-gamma (rhIFN-gamma) was achieved by microencapsulation of rhIFN-gamma in polylactic-coglycolic acid (PLGA) microspheres by a water-in-oil-in-water technique. Water 205-210 interferon gamma Homo sapiens 53-69 18636497-3 1997 Sialylation profiles were quantitated by reversed-phase HPLC separations of the site-specific pools of tryptic glycopeptides representing IFN-gamma"s two potential N-linked glycosylation sites (i.e., Asn(25) and Asn(97)). Glycopeptides 111-124 interferon gamma Homo sapiens 138-147 9282826-6 1997 Altogether, our results raise the possibility that the structural resemblance between p17 and IFN-gamma causes the selective activation of a common pathway resulting in the production of 1,25-dihydroxyvitamin D3. Calcitriol 187-211 interferon gamma Homo sapiens 94-103 9256185-0 1997 Interleukin 6 and interferon-gamma gene expression in lung transplant recipients with refractory acute cellular rejection: implications for monitoring and inhibition by treatment with aerosolized cyclosporine. Cyclosporine 196-208 interferon gamma Homo sapiens 18-34 18636497-3 1997 Sialylation profiles were quantitated by reversed-phase HPLC separations of the site-specific pools of tryptic glycopeptides representing IFN-gamma"s two potential N-linked glycosylation sites (i.e., Asn(25) and Asn(97)). Asparagine 200-203 interferon gamma Homo sapiens 138-147 18636497-3 1997 Sialylation profiles were quantitated by reversed-phase HPLC separations of the site-specific pools of tryptic glycopeptides representing IFN-gamma"s two potential N-linked glycosylation sites (i.e., Asn(25) and Asn(97)). Asparagine 212-215 interferon gamma Homo sapiens 138-147 9218571-0 1997 Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes. Melatonin 0-9 interferon gamma Homo sapiens 35-44 9253958-2 1997 Anandamide was shown to diminish interleukin-6 and interleukin-8 production at low nanomolar concentrations (3-30 nM) but inhibited the production of TNF-alpha, interferon-gamma, interleukin-4 and p75 TNF-alpha soluble receptors at higher concentrations (0.3-3 microM). anandamide 0-10 interferon gamma Homo sapiens 161-177 9253958-3 1997 Palmitoylethanolamide inhibited interleukin-4, interleukin-6, interleukin-8 synthesis and the production of p75 TNF-alpha soluble receptors at concentrations similar to those of anandamide but failed to influence TNF-alpha and interferon-gamma production. palmidrol 0-21 interferon gamma Homo sapiens 227-243 9265988-3 1997 LPS and SEE as single stimuli induced IFN-gamma production to the same extent in CBMC of neonates with high and low risk of atopy. cbmc 81-85 interferon gamma Homo sapiens 38-47 9265988-4 1997 In contrast, a combination of LPS and SEE had a multiplying effect on IFN-gamma secretion only in CBMC of neonates with low risk of atopy. cbmc 98-102 interferon gamma Homo sapiens 70-79 9218571-1 1997 This paper shows that melatonin is able to activate human Th1 lymphocytes by increasing the production of IL-2 and IFN-gamma in vitro. Melatonin 22-31 interferon gamma Homo sapiens 115-124 9258441-2 1997 The recovered pyrene-labeled IFN-gamma (py-IFN-gamma), with an estimated seven pyrene molecules per IFN-gamma, retained over half of its original biological activity. pyrene 14-20 interferon gamma Homo sapiens 29-38 9258441-2 1997 The recovered pyrene-labeled IFN-gamma (py-IFN-gamma), with an estimated seven pyrene molecules per IFN-gamma, retained over half of its original biological activity. pyrene 79-85 interferon gamma Homo sapiens 43-52 9258441-2 1997 The recovered pyrene-labeled IFN-gamma (py-IFN-gamma), with an estimated seven pyrene molecules per IFN-gamma, retained over half of its original biological activity. pyrene 14-20 interferon gamma Homo sapiens 43-52 9258441-2 1997 The recovered pyrene-labeled IFN-gamma (py-IFN-gamma), with an estimated seven pyrene molecules per IFN-gamma, retained over half of its original biological activity. pyrene 79-85 interferon gamma Homo sapiens 43-52 9258441-2 1997 The recovered pyrene-labeled IFN-gamma (py-IFN-gamma), with an estimated seven pyrene molecules per IFN-gamma, retained over half of its original biological activity. pyrene 14-20 interferon gamma Homo sapiens 43-52 9258441-2 1997 The recovered pyrene-labeled IFN-gamma (py-IFN-gamma), with an estimated seven pyrene molecules per IFN-gamma, retained over half of its original biological activity. pyrene 79-85 interferon gamma Homo sapiens 29-38 9246061-9 1997 DAB389IL-2 (10(-12) M) also significantly reduced the numbers of activated helper T cells and IFN-gamma levels in 24-hr cultures. dab389il 0-8 interferon gamma Homo sapiens 94-103 9207463-9 1997 Finally, interferon-gamma (IFN-gamma) also induced G1 growth arrest and upregulated p21 protein expression; as with Dex, affects of IFN-gamma were inhibited by IL-6. Dexamethasone 116-119 interferon gamma Homo sapiens 9-25 9207463-9 1997 Finally, interferon-gamma (IFN-gamma) also induced G1 growth arrest and upregulated p21 protein expression; as with Dex, affects of IFN-gamma were inhibited by IL-6. Dexamethasone 116-119 interferon gamma Homo sapiens 27-36 9207463-9 1997 Finally, interferon-gamma (IFN-gamma) also induced G1 growth arrest and upregulated p21 protein expression; as with Dex, affects of IFN-gamma were inhibited by IL-6. Dexamethasone 116-119 interferon gamma Homo sapiens 132-141 9247563-8 1997 The human colon adenocarcinoma HT-29 cells were sensitized to anti-Fas-R antibody (CH-11) cytotoxicity following treatment with IFN gamma. 4-dimethylamino-3',4'-dimethoxychalcone 83-88 interferon gamma Homo sapiens 128-137 9247563-9 1997 NK-CMC against untreated HT-29 cells was completely inhibited by EGTA/Mg2+ and was unaffected by ZB-4, while both EGTA/Mg2+ and ZB-4 partially inhibited NK-CMC against IFN gamma-treated HT-29 cells. cmc 3-6 interferon gamma Homo sapiens 168-177 9202212-3 1997 Using the tyrosine phosphorylation inhibitor, genistein, and electrophoretic mobility shift assay, we show that IL-6 and IFN-gamma induce nuclear factor STAT-3 and STAT-1 DNA-binding activity to the sis-inducible element of c-fos in a genistein-dependent pathway. Tyrosine 10-18 interferon gamma Homo sapiens 121-130 9202212-3 1997 Using the tyrosine phosphorylation inhibitor, genistein, and electrophoretic mobility shift assay, we show that IL-6 and IFN-gamma induce nuclear factor STAT-3 and STAT-1 DNA-binding activity to the sis-inducible element of c-fos in a genistein-dependent pathway. Genistein 46-55 interferon gamma Homo sapiens 121-130 9202212-3 1997 Using the tyrosine phosphorylation inhibitor, genistein, and electrophoretic mobility shift assay, we show that IL-6 and IFN-gamma induce nuclear factor STAT-3 and STAT-1 DNA-binding activity to the sis-inducible element of c-fos in a genistein-dependent pathway. Genistein 235-244 interferon gamma Homo sapiens 121-130 9207273-1 1997 BACKGROUND & AIMS: The proinflammatory cytokine interferon gamma (IFN-gamma) disrupts epithelial barrier integrity and attenuates secretagogue-induced chloride secretion. Adenosine Monophosphate 12-15 interferon gamma Homo sapiens 52-79 9207273-1 1997 BACKGROUND & AIMS: The proinflammatory cytokine interferon gamma (IFN-gamma) disrupts epithelial barrier integrity and attenuates secretagogue-induced chloride secretion. Chlorides 155-163 interferon gamma Homo sapiens 52-79 9207273-6 1997 RESULTS: IL-10 attenuated the IFN-gamma-induced increase in electrical conductance and totally prevented the IFN-gamma-induced increase in mannitol and inulin fluxes. Mannitol 139-147 interferon gamma Homo sapiens 109-118 9207273-8 1997 IFN-gamma and IL-10 both separately reduced peak forskolin and carbachol-stimulated Isc. Colforsin 49-58 interferon gamma Homo sapiens 0-9 9207273-8 1997 IFN-gamma and IL-10 both separately reduced peak forskolin and carbachol-stimulated Isc. Carbachol 63-72 interferon gamma Homo sapiens 0-9 9207273-11 1997 In addition, both IL-10 and IFN-gamma limit carbachol and forskolin-induced increase in Isc. Carbachol 44-53 interferon gamma Homo sapiens 28-37 9207273-11 1997 In addition, both IL-10 and IFN-gamma limit carbachol and forskolin-induced increase in Isc. Colforsin 58-67 interferon gamma Homo sapiens 28-37 9301524-0 1997 Differential regulation of IFN-gamma, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway. Cyclic AMP 100-110 interferon gamma Homo sapiens 27-36 9815792-1 1997 The combination of IFN-alpha-2a (IFN-alpha) and IFN-gamma-1b (IFN-gamma) has been found to produce more than additive cytotoxicity with fluorouracil (5-FU) in HT 29 colon cancer cells due to enhanced DNA-directed effects. Fluorouracil 136-148 interferon gamma Homo sapiens 48-57 9815792-1 1997 The combination of IFN-alpha-2a (IFN-alpha) and IFN-gamma-1b (IFN-gamma) has been found to produce more than additive cytotoxicity with fluorouracil (5-FU) in HT 29 colon cancer cells due to enhanced DNA-directed effects. Fluorouracil 136-148 interferon gamma Homo sapiens 62-71 9815792-1 1997 The combination of IFN-alpha-2a (IFN-alpha) and IFN-gamma-1b (IFN-gamma) has been found to produce more than additive cytotoxicity with fluorouracil (5-FU) in HT 29 colon cancer cells due to enhanced DNA-directed effects. Fluorouracil 150-154 interferon gamma Homo sapiens 48-57 9815792-1 1997 The combination of IFN-alpha-2a (IFN-alpha) and IFN-gamma-1b (IFN-gamma) has been found to produce more than additive cytotoxicity with fluorouracil (5-FU) in HT 29 colon cancer cells due to enhanced DNA-directed effects. Fluorouracil 150-154 interferon gamma Homo sapiens 62-71 9301524-2 1997 In the present work, we attempted to clarify the role of cAMP on interferon-gamma (IFN-gamma), interleukin (IL)-10, IL-4 and IL-13 expression as well as on the inducible nitric oxide synthase (iNOS) expression. Bucladesine 57-61 interferon gamma Homo sapiens 65-81 9301524-2 1997 In the present work, we attempted to clarify the role of cAMP on interferon-gamma (IFN-gamma), interleukin (IL)-10, IL-4 and IL-13 expression as well as on the inducible nitric oxide synthase (iNOS) expression. Bucladesine 57-61 interferon gamma Homo sapiens 83-92 9301524-3 1997 Treatment of phytohaemagglutinin (PHA)/phorbol 12-myristate 13-acetate (PMA)-activated Jurkat cells with either dibutyryl-cyclic adenosine monophosphate (cAMP) or pentoxifylline induced a strong inhibition of IFN-gamma mRNA expression as measured by reverse transcription (RT)-polymerase chain reaction (PCR), without affecting IL-10 expression. Bucladesine 112-152 interferon gamma Homo sapiens 209-218 9301524-4 1997 Both cholera toxin and prostaglandin E2 (PGE2) induced a strong inhibition of IFN-gamma mRNA expression, whereas IL-10 mRNA expression was significantly enhanced. Dinoprostone 23-39 interferon gamma Homo sapiens 78-87 9301524-4 1997 Both cholera toxin and prostaglandin E2 (PGE2) induced a strong inhibition of IFN-gamma mRNA expression, whereas IL-10 mRNA expression was significantly enhanced. Dinoprostone 41-45 interferon gamma Homo sapiens 78-87 9301524-5 1997 This differential regulation of IFN-gamma and IL-10 expression was related to intracellular cAMP concentration. Bucladesine 92-96 interferon gamma Homo sapiens 32-41 9301524-7 1997 We developed a new method based on immunofluorescence for intracellular cytokine detection followed by optical and computerized image processing, and our results showed that IFN-gamma protein was strongly inhibited when cells were treated with PGE2 or dibutyryl (db)-cAMP, whereas IL-10 protein was enhanced. Dinoprostone 244-248 interferon gamma Homo sapiens 174-183 9301524-7 1997 We developed a new method based on immunofluorescence for intracellular cytokine detection followed by optical and computerized image processing, and our results showed that IFN-gamma protein was strongly inhibited when cells were treated with PGE2 or dibutyryl (db)-cAMP, whereas IL-10 protein was enhanced. dibutyryl (db)- 252-267 interferon gamma Homo sapiens 174-183 9301524-7 1997 We developed a new method based on immunofluorescence for intracellular cytokine detection followed by optical and computerized image processing, and our results showed that IFN-gamma protein was strongly inhibited when cells were treated with PGE2 or dibutyryl (db)-cAMP, whereas IL-10 protein was enhanced. Bucladesine 267-271 interferon gamma Homo sapiens 174-183 9301524-10 1997 The generation of nitric oxide using sodium nitroprusside (SNP) induced a dramatic decrease of IFN-gamma, while IL-10 was enhanced; and conversely the inhibition of iNOS activity using 1-NG-monomethyl arginine (1-NMMA) induced a clear inhibition of IL-10 and IL-4, while IFN-gamma was enhanced. Nitric Oxide 18-30 interferon gamma Homo sapiens 95-104 9301524-10 1997 The generation of nitric oxide using sodium nitroprusside (SNP) induced a dramatic decrease of IFN-gamma, while IL-10 was enhanced; and conversely the inhibition of iNOS activity using 1-NG-monomethyl arginine (1-NMMA) induced a clear inhibition of IL-10 and IL-4, while IFN-gamma was enhanced. Nitric Oxide 18-30 interferon gamma Homo sapiens 271-280 9301524-10 1997 The generation of nitric oxide using sodium nitroprusside (SNP) induced a dramatic decrease of IFN-gamma, while IL-10 was enhanced; and conversely the inhibition of iNOS activity using 1-NG-monomethyl arginine (1-NMMA) induced a clear inhibition of IL-10 and IL-4, while IFN-gamma was enhanced. Nitroprusside 37-57 interferon gamma Homo sapiens 95-104 9301524-10 1997 The generation of nitric oxide using sodium nitroprusside (SNP) induced a dramatic decrease of IFN-gamma, while IL-10 was enhanced; and conversely the inhibition of iNOS activity using 1-NG-monomethyl arginine (1-NMMA) induced a clear inhibition of IL-10 and IL-4, while IFN-gamma was enhanced. Nitroprusside 37-57 interferon gamma Homo sapiens 271-280 9267102-3 1997 Because IFN gamma is synthesized by activated T cells, but not by keratinocytes, these results suggest that Fas may only be effective in apoptosis occurring in T-cell mediated inflammatory skin diseases. ammonium ferrous sulfate 108-111 interferon gamma Homo sapiens 8-17 9330185-0 1997 Inhibition of interferon-gamma production from lymphocytes stimulated with food antigens by a beta 2-agonist, procaterol, in patients with food-sensitive atopic dermatitis. Procaterol 110-120 interferon gamma Homo sapiens 14-30 9815792-9 1997 5-FU clearance was higher in 14 cycles with IFN-gamma compared to the patient"s prior cycle with the same doses of 5-FU/LV/IFN-alpha: 798 +/- 309 versus 601 +/- 250 ml/min/m2 (mean +/- SD; P = 0.04). Fluorouracil 0-4 interferon gamma Homo sapiens 44-53 9815792-15 1997 Compared to our previous experience with 5-FU/LV/IFN-alpha, IFN-gamma and IFN-alpha appeared to have opposite effects on 5-FU clearance. Fluorouracil 121-125 interferon gamma Homo sapiens 60-69 9330185-2 1997 In this study, procaterol dose-dependently inhibited IFN-gamma production of peripheral blood mononuclear cells stimulated with ovalbumin in patients with hen"s egg-sensitive atopic dermatitis, without inhibition of proliferative responses of peripheral blood mononuclear cells. Procaterol 15-25 interferon gamma Homo sapiens 53-62 9195976-5 1997 AS activity in transfected VSMC exceeded that induced in untransfected cells treated for 24 h with a combination of bacterial lipopolysaccharide and interferon-gamma (LPS/IFN). vsmc 27-31 interferon gamma Homo sapiens 149-165 9195941-5 1997 Of the bcl-2 family members, IFN-gamma directly induced bak but notably not bax, which is activated by p53. bakuchiol 56-59 interferon gamma Homo sapiens 29-38 9192770-8 1997 Activation of IFN-gamma-responsive genes requires tyrosine phosphorylation of the transcriptional factor STAT-1alpha (signal transducer and activator of transcription-1alpha). Tyrosine 50-58 interferon gamma Homo sapiens 14-23 9185506-9 1997 Chronic steroid therapy was able to deplete the T cell products IL-2 and IFN-gamma, whereas the activation of tissue-infiltrating macrophages was only partially affected. Steroids 8-15 interferon gamma Homo sapiens 73-82 9190906-2 1997 Furthermore we show that IL-10 production by human T cell lines, such as IFN-gamma and IL-2, is inhibited by the immunosuppressive drugs cyclosporin A and FK506. Cyclosporine 137-150 interferon gamma Homo sapiens 73-82 9190906-2 1997 Furthermore we show that IL-10 production by human T cell lines, such as IFN-gamma and IL-2, is inhibited by the immunosuppressive drugs cyclosporin A and FK506. Tacrolimus 155-160 interferon gamma Homo sapiens 73-82 9190906-3 1997 However, a third immunosuppressive drug, rapamycin, normally associated with inhibiting the effects, but not the production, of cytokines, inhibited IL-10, but not IFN-gamma, production. Sirolimus 41-50 interferon gamma Homo sapiens 164-173 9166857-10 1997 Indeed, IL-10, like IFN-gamma, was able to significantly reduce the amount of B-CLL cell death caused by hydrocortisone-induced apoptosis. Hydrocortisone 105-119 interferon gamma Homo sapiens 20-29 9202135-3 1997 The inhibitor of NO synthase, N(G)-methyl-L-arginine (3 mM), and the cell-permeable superoxide dismutase mimetic Mn(III)tetrakis(4-benzoic acid)porphyrin (300 microM) both reduced the extent of protein oxidation in response to LPS/IFNgamma. manganese(III)-tetrakis(4-benzoic acid)porphyrin 113-153 interferon gamma Homo sapiens 231-239 9166428-5 1997 We determined that one mechanism by which CR3 antibodies may suppress IL-12 production is by the inhibition of IFN-gamma-induced tyrosine phosphorylation. Tyrosine 129-137 interferon gamma Homo sapiens 111-120 9191464-9 1997 Cell cultures treated with TNF alpha/IFN gamma/LPS in combination expressed iNOS mRNA, and this was associated with increases in supernatant nitrite concentrations over 24 h; however, this response diminished with successive passage of cells. Nitrites 141-148 interferon gamma Homo sapiens 37-46 9248621-6 1997 This increased expression of IRF-1 mRNA by IFN-gamma was not blocked by treatment with cycloheximide, but was abolished by treatment with actinomycin D. Dactinomycin 138-151 interferon gamma Homo sapiens 43-52 9182722-0 1997 Interaction of truncated human interferon gamma variants with the interferon gamma receptor: crucial importance of Arg-129. Arginine 115-118 interferon gamma Homo sapiens 31-47 9182722-0 1997 Interaction of truncated human interferon gamma variants with the interferon gamma receptor: crucial importance of Arg-129. Arginine 115-118 interferon gamma Homo sapiens 66-82 9179403-3 1997 IL-1 beta, TNF alpha and interferon-gamma (IFN gamma) are known to stimulate a number of cells to produce inflammatory mediators such as prostaglandins. Prostaglandins 137-151 interferon gamma Homo sapiens 25-41 9277001-0 1997 [Immunomodulation by TYB-2285 of Dermatophagoides farinae (Df) antigen-induced IFN-gamma and IL-4 production in lymphocytes from children with bronchial asthma]. tyb 21-24 interferon gamma Homo sapiens 79-88 9277001-6 1997 Thus reduced production of IFN-gamma by Df-stimulated patients" lymphocytes was increased by TYB-2285 and its metabolites in a dose-dependent manner. tyb 93-96 interferon gamma Homo sapiens 27-36 9179403-3 1997 IL-1 beta, TNF alpha and interferon-gamma (IFN gamma) are known to stimulate a number of cells to produce inflammatory mediators such as prostaglandins. Prostaglandins 137-151 interferon gamma Homo sapiens 43-52 9179403-6 1997 We studied the effects of IL-1 beta, TNF alpha and IFN gamma on the induction of two isoforms of cyclo-oxygenase and its relation to prostaglandin E2 (PGE2) release and COX activity (reflected by PGE2 synthesis from exogenous arachidonic acid) in human cultured airway smooth muscle cells. Dinoprostone 133-149 interferon gamma Homo sapiens 51-60 9179403-6 1997 We studied the effects of IL-1 beta, TNF alpha and IFN gamma on the induction of two isoforms of cyclo-oxygenase and its relation to prostaglandin E2 (PGE2) release and COX activity (reflected by PGE2 synthesis from exogenous arachidonic acid) in human cultured airway smooth muscle cells. Dinoprostone 151-155 interferon gamma Homo sapiens 51-60 9186002-8 1997 ATRA treatment of NB4 cells sensitized them to IFN action as seen by increased IFN-gamma activation site DNA-binding activity or by efficient formation of IFN-alpha-specific ISGF3 complex and subsequent oligoadenylate synthetase and MxB gene expression. Tretinoin 0-4 interferon gamma Homo sapiens 79-88 9182905-0 1997 Different modulation by histamine of IL-4 and interferon-gamma (IFN-gamma) release according to the phenotype of human Th0, Th1 and Th2 clones. Histamine 24-33 interferon gamma Homo sapiens 64-73 9238541-5 1997 Taken together, 5-fluorouracil differentially affects the expression of Interleukin-1, Interferon-gamma and Interleukin-2 receptor. Fluorouracil 16-30 interferon gamma Homo sapiens 87-103 9227325-6 1997 Stimulation of synovial cells with interferon-gamma (IFN-gamma), IL-1 beta, or 12-O-tetradecanoyl phorbol 13-acetate (TPA) markedly enhanced the expression of costimulatory molecules and cytokine production of these cells. Tetradecanoylphorbol Acetate 118-121 interferon gamma Homo sapiens 35-51 9164932-4 1997 The IFN-gamma/IL-10 ratio peaked during the early morning and correlated negatively with plasma cortisol and positively with plasma melatonin. Melatonin 132-141 interferon gamma Homo sapiens 4-13 9164932-5 1997 IFN-gamma and, to a lesser extent, IL-10 production was sensitive to inhibition by exogenous cortisone; the IFN-gamma/IL-10 ratio decreased by >70% after the administration of oral cortisone acetate (25 mg). Cortisone 93-102 interferon gamma Homo sapiens 0-9 9164932-5 1997 IFN-gamma and, to a lesser extent, IL-10 production was sensitive to inhibition by exogenous cortisone; the IFN-gamma/IL-10 ratio decreased by >70% after the administration of oral cortisone acetate (25 mg). Cortisone 93-102 interferon gamma Homo sapiens 108-117 9164932-5 1997 IFN-gamma and, to a lesser extent, IL-10 production was sensitive to inhibition by exogenous cortisone; the IFN-gamma/IL-10 ratio decreased by >70% after the administration of oral cortisone acetate (25 mg). Cortisone 184-201 interferon gamma Homo sapiens 0-9 9164932-5 1997 IFN-gamma and, to a lesser extent, IL-10 production was sensitive to inhibition by exogenous cortisone; the IFN-gamma/IL-10 ratio decreased by >70% after the administration of oral cortisone acetate (25 mg). Cortisone 184-201 interferon gamma Homo sapiens 108-117 9164932-6 1997 Our findings support the concept that plasma cortisol and possibly melatonin regulate diurnal variation in the IFN-gamma/IL-10 ratio. Hydrocortisone 45-53 interferon gamma Homo sapiens 111-120 9164932-6 1997 Our findings support the concept that plasma cortisol and possibly melatonin regulate diurnal variation in the IFN-gamma/IL-10 ratio. Melatonin 67-76 interferon gamma Homo sapiens 111-120 9166751-2 1997 Exposure of astrocytes, in primary culture, to interferon-gamma results in stimulation of nitric oxide synthase activity and increased nitric oxide release. nitric 90-96 interferon gamma Homo sapiens 47-63 9166751-2 1997 Exposure of astrocytes, in primary culture, to interferon-gamma results in stimulation of nitric oxide synthase activity and increased nitric oxide release. Nitric Oxide 90-102 interferon gamma Homo sapiens 47-63 9166751-4 1997 Furthermore, pretreatment of astrocytes with interferon-alpha/beta inhibited (approximately 65%) stimulation by interferon-gamma of nitric oxide synthase activity and nitric oxide release. Nitric Oxide 132-144 interferon gamma Homo sapiens 112-128 9184648-4 1997 Linomide strongly suppressed IFN-gamma and lipopolysaccharide (LPS)-induced IL-1 beta, TNF-alpha and IL-6 mRNA expression in macrophages in vitro as demonstrated by in situ hybridisation. roquinimex 0-8 interferon gamma Homo sapiens 29-38 9210188-0 1997 The effect of benzyl alcohol on recombinant human interferon-gamma. Benzyl Alcohol 14-28 interferon gamma Homo sapiens 50-66 9210188-1 1997 PURPOSE: The goal of this study was to investigate the conformational change and aggregation of recombinant human interferon-gamma (rhIFN-gamma) as a result of interaction between benzyl alcohol and the protein. Benzyl Alcohol 180-194 interferon gamma Homo sapiens 114-130 9202399-0 1997 Involvement of nitric oxide in the interferon-gamma-induced inhibition of growth hormone and prolactin secretion in anterior pituitary cell cultures. Nitric Oxide 15-27 interferon gamma Homo sapiens 35-51 9202399-2 1997 In the present study, we wanted to investigate whether nitric oxide (NO) is involved in this inhibitory action of IFN-gamma. Nitric Oxide 55-67 interferon gamma Homo sapiens 114-123 9202399-5 1997 L-N6-(1-iminoethyl)lysine (L-NIL), a NOS inhibitor with preferential affinity for iNOS, abrogated the IFN-gamma effect on GHRH-stimulated GH secretion and partially reversed IFN-gamma inhibition of PRL release. N(6)-(1-iminoethyl)lysine 0-25 interferon gamma Homo sapiens 102-111 9202399-5 1997 L-N6-(1-iminoethyl)lysine (L-NIL), a NOS inhibitor with preferential affinity for iNOS, abrogated the IFN-gamma effect on GHRH-stimulated GH secretion and partially reversed IFN-gamma inhibition of PRL release. N(6)-(1-iminoethyl)lysine 0-25 interferon gamma Homo sapiens 174-183 9202399-5 1997 L-N6-(1-iminoethyl)lysine (L-NIL), a NOS inhibitor with preferential affinity for iNOS, abrogated the IFN-gamma effect on GHRH-stimulated GH secretion and partially reversed IFN-gamma inhibition of PRL release. N(6)-(1-iminoethyl)lysine 27-32 interferon gamma Homo sapiens 102-111 9202399-5 1997 L-N6-(1-iminoethyl)lysine (L-NIL), a NOS inhibitor with preferential affinity for iNOS, abrogated the IFN-gamma effect on GHRH-stimulated GH secretion and partially reversed IFN-gamma inhibition of PRL release. N(6)-(1-iminoethyl)lysine 27-32 interferon gamma Homo sapiens 174-183 9202399-10 1997 Thus, in culture medium with lower amounts of L-arginine, L-NMMA blocked the IFN-gamma-induced inhibition of GHRH-stimulated GH release at a lower dose. Arginine 46-56 interferon gamma Homo sapiens 77-86 9202399-10 1997 Thus, in culture medium with lower amounts of L-arginine, L-NMMA blocked the IFN-gamma-induced inhibition of GHRH-stimulated GH release at a lower dose. omega-N-Methylarginine 58-64 interferon gamma Homo sapiens 77-86 9202399-11 1997 The inhibition of PRL and GH release by IFN-gamma was markedly reduced in L-arginine-depleted medium. Arginine 74-84 interferon gamma Homo sapiens 40-49 9202399-12 1997 The NO donor sodium nitroprusside (SNP) mimicked the inhibitory action of IFN-gamma on GHRH-stimulated GH and basal PRL release. Nitroprusside 13-33 interferon gamma Homo sapiens 74-83 9202399-15 1997 As studied in different cell populations obtained by unit gravity sedimentation in a serum albumin gradient, L-NMMA reversed the IFN-gamma effect in the same populations enriched in FS cells. omega-N-Methylarginine 109-115 interferon gamma Homo sapiens 129-138 9115299-5 1997 These activities of DFX were associated with a synergistic induction of iNOS mRNA expression and iNOS transcription in IFN-gamma-treated ANA-1 macrophages. Deferoxamine 20-23 interferon gamma Homo sapiens 119-128 9115299-8 1997 We demonstrate that addition of iron sulfate completely abolished DFX or PA induction of HIF-1 binding and iNOS-HRE activation and abrogated IFN-gamma plus either DFX- or PA-induced iNOS expression. ferrous sulfate 32-44 interferon gamma Homo sapiens 141-150 9115299-9 1997 These data establish that DFX is a co-stimulus for the transcriptional activation of the iNOS gene in IFN-gamma-treated macrophages, and they provide evidence that the iNOS-HRE is required for the DFX-dependent activation of the iNOS promoter. Deferoxamine 26-29 interferon gamma Homo sapiens 102-111 9115299-9 1997 These data establish that DFX is a co-stimulus for the transcriptional activation of the iNOS gene in IFN-gamma-treated macrophages, and they provide evidence that the iNOS-HRE is required for the DFX-dependent activation of the iNOS promoter. Deferoxamine 197-200 interferon gamma Homo sapiens 102-111 9139890-5 1997 In addition, all 4 compounds were able to act synergistically with interferon-gamma (IFN-gamma) in all breast cancer cell lines including the retinoid-resistant BT-20 and 734-B lines. Retinoids 142-150 interferon gamma Homo sapiens 67-83 9139890-5 1997 In addition, all 4 compounds were able to act synergistically with interferon-gamma (IFN-gamma) in all breast cancer cell lines including the retinoid-resistant BT-20 and 734-B lines. Retinoids 142-150 interferon gamma Homo sapiens 85-94 9139890-9 1997 RAR-gamma selectively binding retinoids are potent inhibitors of breast cancer cell proliferation, alone and in combination with IFN-gamma. Retinoids 30-39 interferon gamma Homo sapiens 129-138 9182905-4 1997 Histamine inhibited IFN-gamma production by Th1-like cells (P < 0.02, Kruskall-Wallis), especially from bronchial biopsy, but had no effect on IL-4 release. Histamine 0-9 interferon gamma Homo sapiens 20-29 9182905-5 1997 Regarding Th0 clones, histamine inhibited IL-4 production (P < 0.02) in a dose-dependent manner and slightly inhibited IFN-gamma production, but had no effect on Th2-like cells. Histamine 22-31 interferon gamma Homo sapiens 122-131 9182905-7 1997 The H2-receptor antagonist ranitidine completely reversed the inhibition of IL-4 and IFN-gamma production, whereas the agonist dimaprit mimicked this effect. Ranitidine 27-37 interferon gamma Homo sapiens 85-94 9154326-11 1997 The use of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NOS, led to the demonstration of two distinct signalling pathways in IL-1 production by HT29-Cl.16E cells, one dependent on NO (L-NMMA-sensitive) under treatment with IFN gamma/TNF alpha/IL-1 beta, and the other independent of NO (L-NMMA-insensitive) under treatment with IFN gamma/TNF alpha. omega-N-Methylarginine 11-35 interferon gamma Homo sapiens 229-238 9154326-11 1997 The use of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NOS, led to the demonstration of two distinct signalling pathways in IL-1 production by HT29-Cl.16E cells, one dependent on NO (L-NMMA-sensitive) under treatment with IFN gamma/TNF alpha/IL-1 beta, and the other independent of NO (L-NMMA-insensitive) under treatment with IFN gamma/TNF alpha. omega-N-Methylarginine 37-43 interferon gamma Homo sapiens 229-238 9191238-0 1997 Heparin modulates endothelial production of monocyte chemotactic peptide-1 following interferon-gamma stimulation. Heparin 0-7 interferon gamma Homo sapiens 85-101 9191239-0 1997 Endothelial cells: heparin modulates the induction of functional antigen presentation by IFN-gamma. Heparin 19-26 interferon gamma Homo sapiens 89-98 9182905-9 1997 These data demonstrate that histamine has different effects on IL-4 and IFN-gamma release by T helper cells according to their phenotype via H2-receptors. Histamine 28-37 interferon gamma Homo sapiens 72-81 9130007-8 1997 The LPS and IFN-gamma induced CB increases were abolished by cycloheximide or actinomycin D in the cultures, indicating that the increases in CB required increased RNA transcription and de novo protein synthesis. Cycloheximide 61-74 interferon gamma Homo sapiens 12-21 9130007-8 1997 The LPS and IFN-gamma induced CB increases were abolished by cycloheximide or actinomycin D in the cultures, indicating that the increases in CB required increased RNA transcription and de novo protein synthesis. Dactinomycin 78-91 interferon gamma Homo sapiens 12-21 9184913-7 1997 Expression of T cell cytokine gene transcripts (IL-2, IFN gamma, IL-4, IL-10, tumor necrosis factor-alpha and transforming growth factor-beta) are all decreased in spleen cells of donor mice given dMTg. dmtg 197-201 interferon gamma Homo sapiens 54-63 9125556-4 1997 Neutralization of endogenous BMA-driven IL-10 secretion led to augmentation of IFN-gamma in seven of nine MF individuals (1.5- to 10-fold) and did so in a BMA-specific manner (PPD-driven IFN-gamma was augmented in only two of eight MF individuals and only 1.5- to 2-fold), indicating that IL-10 downregulates type 1 responses in these individuals. bma 29-32 interferon gamma Homo sapiens 79-88 9125556-4 1997 Neutralization of endogenous BMA-driven IL-10 secretion led to augmentation of IFN-gamma in seven of nine MF individuals (1.5- to 10-fold) and did so in a BMA-specific manner (PPD-driven IFN-gamma was augmented in only two of eight MF individuals and only 1.5- to 2-fold), indicating that IL-10 downregulates type 1 responses in these individuals. bma 29-32 interferon gamma Homo sapiens 187-196 9130458-9 1997 However, incubation of IFN-gamma treated HSG cells with the synthetic MMP inhibitor BB94 did not alleviate this antiproliferative effect. batimastat 84-88 interferon gamma Homo sapiens 23-32 9129088-6 1997 Pentoxifylline had a temporary effect on mitogen-stimulated cytokine production; thus, interferon-gamma, interleukin (IL)-2, tumor necrosis factor-alpha, and lymphotoxin increased more than IL-10. Pentoxifylline 0-14 interferon gamma Homo sapiens 87-103 9127012-5 1997 Addition of procainamide-hydroxylamine, but not procainamide or its further oxidation products during anergy induction by CD3 engagement, caused a dose-dependent recovery of the capacity of T cells to proliferate and secrete IFN-gamma upon subsequent Ag challenge. procainamide 4-hydroxylamine 12-38 interferon gamma Homo sapiens 225-234 9127012-5 1997 Addition of procainamide-hydroxylamine, but not procainamide or its further oxidation products during anergy induction by CD3 engagement, caused a dose-dependent recovery of the capacity of T cells to proliferate and secrete IFN-gamma upon subsequent Ag challenge. Procainamide 12-24 interferon gamma Homo sapiens 225-234 9140360-6 1997 Results from studies of time kinetics of cytokines imply that IFN-gamma is more agile at the onset of EAMG, probably being one of the initiating factors in the induction of the disease, and IL-4 may be mainly responsible for disease progression and persistance. eamg 102-106 interferon gamma Homo sapiens 62-71 9220579-3 1997 The RT-PCR assay was developed for detection of IL-2, -4, -6, -10, -12, IFN-gamma and actin using cDNA derived from phorbol-stimulated peripheral blood mononuclear leukocytes. phorbol 116-123 interferon gamma Homo sapiens 72-81 9168911-5 1997 In endothelium-denuded segments of pulmonary artery, the inflammatory agennts tumor necrosis factor alpha, interleukin-1 beta, interferon gamma, and lipopolysaccharide stimulated the release of PGE2 and 8-iso PGF2 alpha, which were attenuated in both cases by the cyclo-oxygenase inhibitor indomethacin. Dinoprostone 194-198 interferon gamma Homo sapiens 127-143 9168911-5 1997 In endothelium-denuded segments of pulmonary artery, the inflammatory agennts tumor necrosis factor alpha, interleukin-1 beta, interferon gamma, and lipopolysaccharide stimulated the release of PGE2 and 8-iso PGF2 alpha, which were attenuated in both cases by the cyclo-oxygenase inhibitor indomethacin. 8-iso pgf2 203-213 interferon gamma Homo sapiens 127-143 9168911-5 1997 In endothelium-denuded segments of pulmonary artery, the inflammatory agennts tumor necrosis factor alpha, interleukin-1 beta, interferon gamma, and lipopolysaccharide stimulated the release of PGE2 and 8-iso PGF2 alpha, which were attenuated in both cases by the cyclo-oxygenase inhibitor indomethacin. Indomethacin 290-302 interferon gamma Homo sapiens 127-143 9168934-3 1997 Cisplatin induced tumor necrosis factor-alpha (TNF-alpha) mRNA expression, and an anti-TNF-alpha neutralizing antibody inhibited the induction of iNOS expression by a combination of cisplatin and IFN-gamma in NB-39-nu cells. Cisplatin 0-9 interferon gamma Homo sapiens 196-205 9142139-5 1997 Further, IFN-gamma induction appears to be a late event in the virus replication cycle, since inhibition of HCMV DNA synthesis (e.g., phosphonoacetic acid) blocked the increase in IFN-gamma. Phosphonoacetic Acid 134-154 interferon gamma Homo sapiens 9-18 9142139-5 1997 Further, IFN-gamma induction appears to be a late event in the virus replication cycle, since inhibition of HCMV DNA synthesis (e.g., phosphonoacetic acid) blocked the increase in IFN-gamma. Phosphonoacetic Acid 134-154 interferon gamma Homo sapiens 180-189 9142139-7 1997 The appearance of IFN-gamma at late stages of HCMV infection and its elimination in the presence of an inhibitor (Actinomycin D) of RNA synthesis indicate a true transcriptional induction of this lymphokine at the RNA and protein levels. Dactinomycin 114-127 interferon gamma Homo sapiens 18-27 9155954-4 1997 The addition of increasing doses (10(-9)-10(-5) mol/l) of calcitriol to these T cells resulted in a dose-dependent inhibition in lymphocyte proliferation and in production of the type 1 cytokines IFN-gamma and IL-2, the type 2 cytokines IL-4 and IL-5. Calcitriol 58-68 interferon gamma Homo sapiens 196-205 9186631-0 1997 Lysophosphatidylcholine induces heparin-binding epidermal growth factor-like growth factor and interferon-gamma in human T-lymphocytes. Lysophosphatidylcholines 0-23 interferon gamma Homo sapiens 95-111 9092512-11 1997 Tyr-phosphorylated ICSBP and IRF-2 are detected in expressing cells constitutively, and Tyr-phosphorylated IRF-1 is induced by IFN-gamma. Tyrosine 0-3 interferon gamma Homo sapiens 127-136 9092512-11 1997 Tyr-phosphorylated ICSBP and IRF-2 are detected in expressing cells constitutively, and Tyr-phosphorylated IRF-1 is induced by IFN-gamma. Tyrosine 88-91 interferon gamma Homo sapiens 127-136 9135186-7 1997 Decreased IFN gamma (p < 0.001) and IL-4 concentrations (p < 0.01) were found in the presence of thiopentone, but IL-2 production was unaffected. Thiopental 103-114 interferon gamma Homo sapiens 10-19 9135186-9 1997 Propofol 10 micrograms.ml-1 increased the IFN gamma/IL-4 ratio from the control value median 243 (162-562) (25th-75th percentile) to 363 (195-1028) (p < 0.01), but thiopentone decreased it to 145 (60-214) (p < 0.01). Propofol 0-8 interferon gamma Homo sapiens 42-51 9163517-4 1997 A protein synthesis inhibitor, cycloheximide, significantly inhibited cell death, implying that IFN-gamma induces de novo proteins involved in the death of hepatocytes. Cycloheximide 31-44 interferon gamma Homo sapiens 96-105 9176098-3 1997 After monocytes were primed with lipopolysaccharide (LPS) or interferon-gamma (IFN-gamma) for 18 hr in suspension culture, they produced a high amount of superoxide (O2-) when triggered by phorbol myristate acetate. Superoxides 154-164 interferon gamma Homo sapiens 61-77 9176098-3 1997 After monocytes were primed with lipopolysaccharide (LPS) or interferon-gamma (IFN-gamma) for 18 hr in suspension culture, they produced a high amount of superoxide (O2-) when triggered by phorbol myristate acetate. Superoxides 154-164 interferon gamma Homo sapiens 79-88 9176098-3 1997 After monocytes were primed with lipopolysaccharide (LPS) or interferon-gamma (IFN-gamma) for 18 hr in suspension culture, they produced a high amount of superoxide (O2-) when triggered by phorbol myristate acetate. Superoxides 166-168 interferon gamma Homo sapiens 61-77 9176098-3 1997 After monocytes were primed with lipopolysaccharide (LPS) or interferon-gamma (IFN-gamma) for 18 hr in suspension culture, they produced a high amount of superoxide (O2-) when triggered by phorbol myristate acetate. Superoxides 166-168 interferon gamma Homo sapiens 79-88 9176098-3 1997 After monocytes were primed with lipopolysaccharide (LPS) or interferon-gamma (IFN-gamma) for 18 hr in suspension culture, they produced a high amount of superoxide (O2-) when triggered by phorbol myristate acetate. Tetradecanoylphorbol Acetate 189-214 interferon gamma Homo sapiens 61-77 9176098-3 1997 After monocytes were primed with lipopolysaccharide (LPS) or interferon-gamma (IFN-gamma) for 18 hr in suspension culture, they produced a high amount of superoxide (O2-) when triggered by phorbol myristate acetate. Tetradecanoylphorbol Acetate 189-214 interferon gamma Homo sapiens 79-88 9176098-4 1997 C2- or C6-ceramide inhibited O2- release from monocytes primed with LPS (1 ng/ml) or IFN-gamma (100 U/ml), but did not affect unprimed monocytes. Ceramides 10-18 interferon gamma Homo sapiens 85-94 9077486-7 1997 That IgG-anti-MC stimulates an increase in IL-1beta and IFN-gamma production in controls suggests that IgG-anti-MC may play a role in melanocyte destruction mediated by monocytes. Methylcholanthrene 14-16 interferon gamma Homo sapiens 56-65 9176105-8 1997 AcLDL stimulated IL-8 secretion > TNF-alpha > IL-1 alpha > IL-2 = IFN-gamma = IL-1 beta, and decreased GM-CSF secretion eightfold. acldl 0-5 interferon gamma Homo sapiens 75-84 9120265-9 1997 IFN-gamma also inhibited uridine incorporation by cultured B cells, and cells cultured in IFN-gamma showed no size increase. Uridine 25-32 interferon gamma Homo sapiens 0-9 9119978-4 1997 The numbers of cells secreting IL-2 upon stimulation with human acetylcholine receptor correlated with those secreting IFN-gamma. Acetylcholine 64-77 interferon gamma Homo sapiens 119-128 9119982-3 1997 Dose and time dependent increases in intracellular CB were seen when cells primed with phorbol ester (PMA) were cultured with IFN-gamma. Phorbol Esters 87-100 interferon gamma Homo sapiens 126-135 9119982-3 1997 Dose and time dependent increases in intracellular CB were seen when cells primed with phorbol ester (PMA) were cultured with IFN-gamma. Tetradecanoylphorbol Acetate 102-105 interferon gamma Homo sapiens 126-135 9178369-2 1997 Exposure of PAEC to the combination of IFN-gamma, TNF-alpha, and IL-1 beta did not alter iNOS activity in cytosolic and membrane fractions but significantly (p < 0.01) reduced eNOS activity in the membrane fraction, but not in the cytosolic fraction, after a 24-h exposure. paec 12-16 interferon gamma Homo sapiens 39-48 9126339-9 1997 Furthermore, NG-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, significantly decreased IFN-gamma induced elevations in medium levels of Epo and nitrite as well as cGMP levels in Hep3B cells. Nitrites 163-170 interferon gamma Homo sapiens 106-115 9103535-0 1997 Nitric oxide-mediated inhibition of cytochrome P450 by interferon-gamma in human hepatocytes. Nitric Oxide 0-12 interferon gamma Homo sapiens 55-71 9103535-1 1997 The role of nitric oxide in the inhibition of the cytochrome P450 system produced by interferon-gamma in human hepatocytes has been examined. Nitric Oxide 12-24 interferon gamma Homo sapiens 85-101 9103535-3 1997 After 24 hr of treatment with 300 U/ml interferon-gamma, a rise in nitric oxide release (200% over control cells) and a parallel inhibition in 7-ethoxyresorufin O-deethylase activity (50% of control) were observed in human hepatocytes. Nitric Oxide 67-79 interferon gamma Homo sapiens 39-55 9103535-3 1997 After 24 hr of treatment with 300 U/ml interferon-gamma, a rise in nitric oxide release (200% over control cells) and a parallel inhibition in 7-ethoxyresorufin O-deethylase activity (50% of control) were observed in human hepatocytes. ethoxyresorufin 145-160 interferon gamma Homo sapiens 39-55 9103535-6 1997 Decreases in CYP1A2 activity found after exposure of 3-methylcholanthrene-treated hepatocytes to interferon-gamma were also reversed in the presence of N(G)-monomethyl-L-arginine. Methylcholanthrene 53-73 interferon gamma Homo sapiens 97-113 9103535-6 1997 Decreases in CYP1A2 activity found after exposure of 3-methylcholanthrene-treated hepatocytes to interferon-gamma were also reversed in the presence of N(G)-monomethyl-L-arginine. omega-N-Methylarginine 152-178 interferon gamma Homo sapiens 97-113 9103535-8 1997 This study suggests that at least some of the interferon-gamma effects on human hepatocyte cytochrome P450 isoenzymes are mediated by nitric oxide biosynthesis. Nitric Oxide 134-146 interferon gamma Homo sapiens 46-62 9103544-9 1997 Ethanol exposure also inhibited NOS-2 activity induced by LPS plus interferon-gamma, by LPS plus tumor necrosis factor-alpha and by tumor necrosis factor-alpha alone. Ethanol 0-7 interferon gamma Homo sapiens 67-83 9126339-7 1997 IFN-gamma produced significant increases in medium levels of Epo and nitrite. Nitrites 69-76 interferon gamma Homo sapiens 0-9 9126339-8 1997 IFN-gamma also significantly increased cGMP levels in Hep3B cells. Cyclic GMP 39-43 interferon gamma Homo sapiens 0-9 9113096-3 1997 T-cell-derived interferon-gamma leads to the expression of various proinflammatory cytokines and enhanced macrophage capacity to secrete reactive oxygen intermediates. reactive oxygen intermediates 137-166 interferon gamma Homo sapiens 15-31 9126339-9 1997 Furthermore, NG-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, significantly decreased IFN-gamma induced elevations in medium levels of Epo and nitrite as well as cGMP levels in Hep3B cells. NG-Nitroarginine Methyl Ester 13-45 interferon gamma Homo sapiens 106-115 9126339-9 1997 Furthermore, NG-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, significantly decreased IFN-gamma induced elevations in medium levels of Epo and nitrite as well as cGMP levels in Hep3B cells. NG-Nitroarginine Methyl Ester 47-53 interferon gamma Homo sapiens 106-115 9065411-4 1997 In fact, a 30-min treatment of T67 cells with the combination of lipopolysaccharide plus interferon-gamma (MIX) strongly inhibits the cNOS activity, as determined by measuring [3H]citrulline production. Tritium 177-179 interferon gamma Homo sapiens 89-105 9065411-4 1997 In fact, a 30-min treatment of T67 cells with the combination of lipopolysaccharide plus interferon-gamma (MIX) strongly inhibits the cNOS activity, as determined by measuring [3H]citrulline production. Citrulline 180-190 interferon gamma Homo sapiens 89-105 9073392-8 1997 Our data suggest that AS-101 is a partial IFN-gamma agonist and may explain the shift toward the release of Th-1 type cytokines observed in AS-101-treated patients. ammonium trichloro(dioxoethylene-O,O'-)tellurate 22-28 interferon gamma Homo sapiens 42-51 9093903-3 1997 On the reconstituted extracellular matrix (ECM) Matrigel freshly isolated HUVECs treated with interleukin-1 beta, lipopolysaccharide, and interferon-gamma, produced more NO, but less PGI2, than on gelatin substratum. Epoprostenol 183-187 interferon gamma Homo sapiens 138-154 9113096-4 1997 In addition, interferon-gamma is the major stimulator for the biosynthesis of neopterin and its reduced form, 7,8-dihydroneopterin. Neopterin 78-87 interferon gamma Homo sapiens 13-29 9113096-4 1997 In addition, interferon-gamma is the major stimulator for the biosynthesis of neopterin and its reduced form, 7,8-dihydroneopterin. 7,8-dihydroneopterin 110-130 interferon gamma Homo sapiens 13-29 9093132-10 1997 The increase of IFN gamma, the most active principle inducing neopterin release, was below the concentration needed for neopterin stimulation. Neopterin 62-71 interferon gamma Homo sapiens 16-25 9118961-9 1997 Conversely, a catalytically inactive mutant that carried a lysine to alanine substitution within the kinase domain, displayed dominant-negative features and protected cells from interferon-gamma-induced cell death. Lysine 59-65 interferon gamma Homo sapiens 178-194 9118961-9 1997 Conversely, a catalytically inactive mutant that carried a lysine to alanine substitution within the kinase domain, displayed dominant-negative features and protected cells from interferon-gamma-induced cell death. Alanine 69-76 interferon gamma Homo sapiens 178-194 9047011-3 1997 In the present study we examined the effects of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and interferon-gamma (IFN-gamma) on progesterone and prostaglandin (PGE2, PGF2 alpha) production by primate luteal cells in vitro. Prostaglandins 174-187 interferon gamma Homo sapiens 143-152 9047011-3 1997 In the present study we examined the effects of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and interferon-gamma (IFN-gamma) on progesterone and prostaglandin (PGE2, PGF2 alpha) production by primate luteal cells in vitro. Progesterone 157-169 interferon gamma Homo sapiens 125-141 9047011-3 1997 In the present study we examined the effects of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and interferon-gamma (IFN-gamma) on progesterone and prostaglandin (PGE2, PGF2 alpha) production by primate luteal cells in vitro. Dinoprostone 189-193 interferon gamma Homo sapiens 143-152 9047011-3 1997 In the present study we examined the effects of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and interferon-gamma (IFN-gamma) on progesterone and prostaglandin (PGE2, PGF2 alpha) production by primate luteal cells in vitro. Progesterone 157-169 interferon gamma Homo sapiens 143-152 9303208-5 1997 The presence of external stress factors, such as interferon-gamma (IFN-gamma)-mediated nitric oxide (NO) formation has been identified to stabilize the cyst stage, most likely by activation of promoter(s) which drive the expression of genes encoding bradyzoite-specific antigens. Nitric Oxide 87-99 interferon gamma Homo sapiens 49-65 9138698-13 1997 However, a mixture of cytokines (interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) each at 10 ng ml-1) induced COX-2 mRNA expression, which was maximal at 12 h and inhibited by dexamethasone (1 microM; added 30 min before the cytokines). Dexamethasone 233-246 interferon gamma Homo sapiens 110-126 9138698-13 1997 However, a mixture of cytokines (interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) each at 10 ng ml-1) induced COX-2 mRNA expression, which was maximal at 12 h and inhibited by dexamethasone (1 microM; added 30 min before the cytokines). Dexamethasone 233-246 interferon gamma Homo sapiens 128-137 9138698-17 1997 Incubation of the cells with the cytokine mixture (IL-1 beta, TNF alpha, IFN gamma each at 10 ng ml-1 for 24 h) caused the accumulation of PGE2 and 6-keto-PGF1 alpha. Dinoprostone 139-143 interferon gamma Homo sapiens 73-82 9138698-17 1997 Incubation of the cells with the cytokine mixture (IL-1 beta, TNF alpha, IFN gamma each at 10 ng ml-1 for 24 h) caused the accumulation of PGE2 and 6-keto-PGF1 alpha. 6-keto-pgf1 148-159 interferon gamma Homo sapiens 73-82 9303208-5 1997 The presence of external stress factors, such as interferon-gamma (IFN-gamma)-mediated nitric oxide (NO) formation has been identified to stabilize the cyst stage, most likely by activation of promoter(s) which drive the expression of genes encoding bradyzoite-specific antigens. Nitric Oxide 87-99 interferon gamma Homo sapiens 67-76 9067535-5 1997 By contrast, when PBMC were treated with colchicine or colcemide a significant reduction in neopterin formation was evident in cells without and with prestimulation by IFN-gamma or LPS. Colchicine 41-51 interferon gamma Homo sapiens 168-177 9067535-5 1997 By contrast, when PBMC were treated with colchicine or colcemide a significant reduction in neopterin formation was evident in cells without and with prestimulation by IFN-gamma or LPS. Demecolcine 55-64 interferon gamma Homo sapiens 168-177 9067535-5 1997 By contrast, when PBMC were treated with colchicine or colcemide a significant reduction in neopterin formation was evident in cells without and with prestimulation by IFN-gamma or LPS. Neopterin 92-101 interferon gamma Homo sapiens 168-177 9067536-0 1997 Examination of the mechanism by which heparin antagonizes activation of a model endothelium by interferon-gamma (IFN-gamma). Heparin 38-45 interferon gamma Homo sapiens 95-111 9067536-0 1997 Examination of the mechanism by which heparin antagonizes activation of a model endothelium by interferon-gamma (IFN-gamma). Heparin 38-45 interferon gamma Homo sapiens 113-122 9067536-2 1997 In this study the mechanism by which the glycosaminoglycan (GAG) heparin antagonizes the activation of a model endothelium by IFN-gamma was investigated. Glycosaminoglycans 41-58 interferon gamma Homo sapiens 126-135 9067536-3 1997 Radioligand binding assays demonstrated that total binding of 125I-IFN-gamma to the EAhy.926 endothelial hybridoma cell line was reduced in the presence of heparin or heparan sulphate (HS); the structurally dissimilar GAG chondroitin sulphate had no effect. Heparin 156-163 interferon gamma Homo sapiens 67-76 9067536-3 1997 Radioligand binding assays demonstrated that total binding of 125I-IFN-gamma to the EAhy.926 endothelial hybridoma cell line was reduced in the presence of heparin or heparan sulphate (HS); the structurally dissimilar GAG chondroitin sulphate had no effect. Heparitin Sulfate 167-183 interferon gamma Homo sapiens 67-76 9067536-3 1997 Radioligand binding assays demonstrated that total binding of 125I-IFN-gamma to the EAhy.926 endothelial hybridoma cell line was reduced in the presence of heparin or heparan sulphate (HS); the structurally dissimilar GAG chondroitin sulphate had no effect. Heparitin Sulfate 185-187 interferon gamma Homo sapiens 67-76 9067536-3 1997 Radioligand binding assays demonstrated that total binding of 125I-IFN-gamma to the EAhy.926 endothelial hybridoma cell line was reduced in the presence of heparin or heparan sulphate (HS); the structurally dissimilar GAG chondroitin sulphate had no effect. gag chondroitin sulphate 218-242 interferon gamma Homo sapiens 67-76 9067536-4 1997 Treatment of the cells with chlorate, a metabolic inhibitor of GAG sulphation, was found to reduce both the subsequent binding of IFN-gamma and its ability to induce expression of class II MHC antigens. Chlorates 28-36 interferon gamma Homo sapiens 130-139 9067536-4 1997 Treatment of the cells with chlorate, a metabolic inhibitor of GAG sulphation, was found to reduce both the subsequent binding of IFN-gamma and its ability to induce expression of class II MHC antigens. Glycosaminoglycans 63-66 interferon gamma Homo sapiens 130-139 9067536-7 1997 These results appear to demonstrate that IFN-gamma is sequestered at the surface of endothelial cells by electrostatic interaction between specific basic amino acid residues and sulphated domains on HS, the most abundant endothelial GAG. Amino Acids, Basic 148-164 interferon gamma Homo sapiens 41-50 9067536-7 1997 These results appear to demonstrate that IFN-gamma is sequestered at the surface of endothelial cells by electrostatic interaction between specific basic amino acid residues and sulphated domains on HS, the most abundant endothelial GAG. Glycosaminoglycans 233-236 interferon gamma Homo sapiens 41-50 9179606-3 1997 The results demonstrated that IFN gamma was able to modulate EGF receptor of HepG2 cells by enhancing the tyrosine phosphorylation of the receptor. Tyrosine 106-114 interferon gamma Homo sapiens 30-39 9130606-4 1997 We transfected a metal inducible expression plasmid capable of expressing poly(ADP-ribose) synthetase gene into thyroid carcinoma 8505C cells and the transformants, treated with metal and IFN-gamma, were separated by Magnetic Cell Separation. Metals 17-22 interferon gamma Homo sapiens 188-197 9179606-7 1997 Because IFN gamma is an inhibitory agent for the growth of HepG2 cells, this transmodulatory effect of IFN gamma on the tyrosine phosphorylation of EGF receptor might be associated with the inhibition of the growth of HepG2 cells. Tyrosine 120-128 interferon gamma Homo sapiens 8-17 9179606-7 1997 Because IFN gamma is an inhibitory agent for the growth of HepG2 cells, this transmodulatory effect of IFN gamma on the tyrosine phosphorylation of EGF receptor might be associated with the inhibition of the growth of HepG2 cells. Tyrosine 120-128 interferon gamma Homo sapiens 103-112 9306155-3 1997 Chenodeoxycholic acid inhibited phytohemagglutinin-induced lymphocyte proliferation and interferon-gamma secretion, and phytohemagglutinin and pokeweed-mediated interleukin 2 secretion. Chenodeoxycholic Acid 0-21 interferon gamma Homo sapiens 88-104 9155534-1 1997 The antiproliferative effect of 5-fluorouracil (5-FU) in colon cancer can be enhanced by interferons (IFN-alpha and IFN-gamma). Fluorouracil 32-46 interferon gamma Homo sapiens 116-125 9155534-1 1997 The antiproliferative effect of 5-fluorouracil (5-FU) in colon cancer can be enhanced by interferons (IFN-alpha and IFN-gamma). Fluorouracil 48-52 interferon gamma Homo sapiens 116-125 9155534-4 1997 It has been shown that IFN-gamma can prevent 5-FU induced overexpression of TS. Fluorouracil 45-49 interferon gamma Homo sapiens 23-32 9155534-6 1997 A 1.5-fold increase in 5-FU sensitivity was observed in C26-10 and C26-10/F (by murine IFN-alpha, beta); in SW948, WiDr and WiDr/F (by human IFN-gamma) and in SW948 and WiDr/ F (by human IFN-alpha). Fluorouracil 23-27 interferon gamma Homo sapiens 141-150 9062364-2 1997 In secondary cultures of normal human bronchial epithelial cells (NHBECs), interferon-gamma (IFN-gamma, 10 ng/ml for 24 h) increased the amount of prostaglandin E2 (PGE2) released in response to stimulation with exogenous arachidonic acid (5 microM). Dinoprostone 147-163 interferon gamma Homo sapiens 75-91 9062364-2 1997 In secondary cultures of normal human bronchial epithelial cells (NHBECs), interferon-gamma (IFN-gamma, 10 ng/ml for 24 h) increased the amount of prostaglandin E2 (PGE2) released in response to stimulation with exogenous arachidonic acid (5 microM). Dinoprostone 147-163 interferon gamma Homo sapiens 93-102 9062364-2 1997 In secondary cultures of normal human bronchial epithelial cells (NHBECs), interferon-gamma (IFN-gamma, 10 ng/ml for 24 h) increased the amount of prostaglandin E2 (PGE2) released in response to stimulation with exogenous arachidonic acid (5 microM). Dinoprostone 165-169 interferon gamma Homo sapiens 75-91 9062364-2 1997 In secondary cultures of normal human bronchial epithelial cells (NHBECs), interferon-gamma (IFN-gamma, 10 ng/ml for 24 h) increased the amount of prostaglandin E2 (PGE2) released in response to stimulation with exogenous arachidonic acid (5 microM). Dinoprostone 165-169 interferon gamma Homo sapiens 93-102 9062364-2 1997 In secondary cultures of normal human bronchial epithelial cells (NHBECs), interferon-gamma (IFN-gamma, 10 ng/ml for 24 h) increased the amount of prostaglandin E2 (PGE2) released in response to stimulation with exogenous arachidonic acid (5 microM). Arachidonic Acid 222-238 interferon gamma Homo sapiens 75-91 9062364-2 1997 In secondary cultures of normal human bronchial epithelial cells (NHBECs), interferon-gamma (IFN-gamma, 10 ng/ml for 24 h) increased the amount of prostaglandin E2 (PGE2) released in response to stimulation with exogenous arachidonic acid (5 microM). Arachidonic Acid 222-238 interferon gamma Homo sapiens 93-102 9062364-7 1997 Furthermore, IFN-gamma induced the expression of RNAs for a number of ligands at the EGF receptor TGF-alpha; heparin-binding EGF-like growth factor (HB-EGF); and amphiregulin in NHBECs, and when administered exogenously, these ligands increased PGE2 release from NHBECs. Dinoprostone 245-249 interferon gamma Homo sapiens 13-22 9062364-8 1997 Heparin at the concentration that neutralized the function of amphiregulin, or antibodies against TGFalpha or HB-EGF also reduced the release of PGE2 from IFN-gamma-stimulated NHBECs. Heparin 0-7 interferon gamma Homo sapiens 155-164 9062364-8 1997 Heparin at the concentration that neutralized the function of amphiregulin, or antibodies against TGFalpha or HB-EGF also reduced the release of PGE2 from IFN-gamma-stimulated NHBECs. Dinoprostone 145-149 interferon gamma Homo sapiens 155-164 9036928-8 1997 These data show that pervanadate can mimic each step in the IFNgamma-mediated pathway leading to ICAM-1 expression, demonstrate the ability of a pharmacologic agent to bypass the standard cytokine-receptor interaction required for increased ICAM-1 expression, and emphasize the importance of protein tyrosine phosphatases and protein tyrosine kinases in mediating inflammatory responses in the skin. pervanadate 21-32 interferon gamma Homo sapiens 60-68 9036928-0 1997 Pervanadate mimics IFNgamma-mediated induction of ICAM-1 expression via activation of STAT proteins. pervanadate 0-11 interferon gamma Homo sapiens 19-27 9036928-3 1997 pIgammaRE is homologous to IFNgamma-activated sequences, which bind to tyrosine phosphorylated members of the transcription factor family known as signal transducers and activators of transcription (STAT). Tyrosine 71-79 interferon gamma Homo sapiens 27-35 9106231-2 1997 Cultures of human fetal astrocytes and microglia produce inducible nitric oxide synthase and nitric oxide in response to Interferon gamma and Interleukin 1 beta. Nitric Oxide 67-79 interferon gamma Homo sapiens 121-137 9089795-4 1997 PGE2 inhibited the release of IL-2 and IFN-gamma, while iloprost did not affect their production. Dinoprostone 0-4 interferon gamma Homo sapiens 39-48 9045922-6 1997 Conversely, rIL-7 and recombinant interferon-gamma restored proliferation of peripheral blood lymphocytes stimulated by PHA in the presence of cyclosporin A but did not restore sensitivity to class I-mediated apoptosis. Cyclosporine 143-156 interferon gamma Homo sapiens 34-50 9122616-6 1997 When IL-10 and IFN-gamma were added simultaneously to neutrophil culture, IL-10 dose-dependently reduced IFN-gamma-induced increase of CR3 expression, O(2)- production (in response to both FMLP and phorbol 12-myristate 13-acetate, or PMA) and ADCC, but did not change Fc gamma RI expression on phagocytes. o(2) 151-155 interferon gamma Homo sapiens 15-24 9122616-6 1997 When IL-10 and IFN-gamma were added simultaneously to neutrophil culture, IL-10 dose-dependently reduced IFN-gamma-induced increase of CR3 expression, O(2)- production (in response to both FMLP and phorbol 12-myristate 13-acetate, or PMA) and ADCC, but did not change Fc gamma RI expression on phagocytes. o(2) 151-155 interferon gamma Homo sapiens 105-114 9122616-6 1997 When IL-10 and IFN-gamma were added simultaneously to neutrophil culture, IL-10 dose-dependently reduced IFN-gamma-induced increase of CR3 expression, O(2)- production (in response to both FMLP and phorbol 12-myristate 13-acetate, or PMA) and ADCC, but did not change Fc gamma RI expression on phagocytes. Tetradecanoylphorbol Acetate 198-229 interferon gamma Homo sapiens 15-24 9122616-6 1997 When IL-10 and IFN-gamma were added simultaneously to neutrophil culture, IL-10 dose-dependently reduced IFN-gamma-induced increase of CR3 expression, O(2)- production (in response to both FMLP and phorbol 12-myristate 13-acetate, or PMA) and ADCC, but did not change Fc gamma RI expression on phagocytes. Tetradecanoylphorbol Acetate 198-229 interferon gamma Homo sapiens 105-114 9029124-6 1997 RANTES production induced by TNF-alpha and IFN-gamma was inhibited partly by the Th2-derived cytokines, IL-4, IL-10, and IL-13, as well as by dexamethasone. Dexamethasone 142-155 interferon gamma Homo sapiens 43-52 9032125-2 1997 In order to study the mechanisms of cytostasis in mesothelioma cells, we examined two IFN-gamma-controlled metabolic pathways known to mediate growth arrest in various cell types, measuring production of the antiproliferative compound nitric oxide (NO) and degradation of tryptophan in nine human mesothelioma cell lines (HMCLs) displaying different sensitivities to the antiproliferative effect of r-hu-IFN-gamma. Tryptophan 272-282 interferon gamma Homo sapiens 86-95 9032125-6 1997 In responsive HMCLs, r-hu-IFN-gamma induced strong indoleamine-2,3-dioxygenase (IDO) activity, which causes rapid degradation of tryptophan; however, the correlation between r-hu-IFN-gamma-mediated growth arrest and IDO induction was not absolute. Tryptophan 129-139 interferon gamma Homo sapiens 26-35 9135559-8 1997 Both the basal level of CD71 and IL-4, IFN-gamma or TNF-alpha-driven expression was diminished on calcitriol-treated U937 cells. Calcitriol 98-108 interferon gamma Homo sapiens 39-48 9080423-2 1997 Microglia and macrophages significantly increased quinolinic acid synthesis from tryptophan following activation by either lipopolysaccharide or interferon-gamma. Quinolinic Acid 50-65 interferon gamma Homo sapiens 145-161 9135559-5 1997 The basal as well as IL-4, IL-6, IFN-gamma, TNF-alpha and TGF-beta-driven levels of HLA-ABC Ag were significantly diminished by calcitriol. Calcitriol 128-138 interferon gamma Homo sapiens 33-42 9059994-8 1997 Similarly, transcriptional induction of chimeric reporter plasmids driven by an IFN-gamma inducible promoter (GAS; IFN-gamma activated site) was also enhanced by the combination of IFN-gamma and tamoxifen. Tamoxifen 195-204 interferon gamma Homo sapiens 80-89 9059994-8 1997 Similarly, transcriptional induction of chimeric reporter plasmids driven by an IFN-gamma inducible promoter (GAS; IFN-gamma activated site) was also enhanced by the combination of IFN-gamma and tamoxifen. Tamoxifen 195-204 interferon gamma Homo sapiens 115-124 9059994-8 1997 Similarly, transcriptional induction of chimeric reporter plasmids driven by an IFN-gamma inducible promoter (GAS; IFN-gamma activated site) was also enhanced by the combination of IFN-gamma and tamoxifen. Tamoxifen 195-204 interferon gamma Homo sapiens 115-124 9059994-9 1997 In tamoxifen treated cells, IFN-beta and IFN-gamma readily activated transcription factors ISGF-3 and GAF, respectively. Tamoxifen 3-12 interferon gamma Homo sapiens 41-50 9042533-5 1997 The intensity of these fluorescence spots increased after brief treatment with hIFN-gamma or CPT-cAMP. cpt-camp 93-101 interferon gamma Homo sapiens 79-89 9080423-2 1997 Microglia and macrophages significantly increased quinolinic acid synthesis from tryptophan following activation by either lipopolysaccharide or interferon-gamma. Tryptophan 81-91 interferon gamma Homo sapiens 145-161 9330666-0 1997 Inhibitory effect of pentoxifylline on HLA-DR expression and glycosaminoglycan synthesis of retrobulbar fibroblasts induced by interferon gamma. Pentoxifylline 21-35 interferon gamma Homo sapiens 127-143 9051197-10 1997 The lipid accumulation which was induced by HS was potently inhibited (but not reserved) by the inflammatory cytokine interferon-gamma (IFN gamma), and this was associated with decreased apo E production, LPL secretion and expression of LRP. hassio 44-46 interferon gamma Homo sapiens 118-134 9051197-10 1997 The lipid accumulation which was induced by HS was potently inhibited (but not reserved) by the inflammatory cytokine interferon-gamma (IFN gamma), and this was associated with decreased apo E production, LPL secretion and expression of LRP. hassio 44-46 interferon gamma Homo sapiens 136-145 9330666-0 1997 Inhibitory effect of pentoxifylline on HLA-DR expression and glycosaminoglycan synthesis of retrobulbar fibroblasts induced by interferon gamma. Glycosaminoglycans 61-78 interferon gamma Homo sapiens 127-143 9330666-3 1997 Pentoxifylline (Ptx) is known to have complex immunomodulatory effects on production of cytokines including interferon gamma (IFN-gamma). Pentoxifylline 0-14 interferon gamma Homo sapiens 108-135 9330666-3 1997 Pentoxifylline (Ptx) is known to have complex immunomodulatory effects on production of cytokines including interferon gamma (IFN-gamma). Pentoxifylline 16-19 interferon gamma Homo sapiens 108-135 9330666-5 1997 We wished to determine whether Ptx has an effect on the IFN-gamma induced HLA-DR expression and influences the spontaneous and cytokine-induced GAG synthesis of REF. Pentoxifylline 31-34 interferon gamma Homo sapiens 56-65 10103145-2 1997 Urinary neopterin is an index of this systemic immune activation, reflecting the circulating activity of interferon-gamma. Neopterin 8-17 interferon gamma Homo sapiens 105-121 9330666-13 1997 Both spontaneous and IFN-gamma-induced GAG synthesis of REF was inhibited by Ptx (100, 500 and 1000 mg/l, respectively). Glycosaminoglycans 39-42 interferon gamma Homo sapiens 21-30 9330666-13 1997 Both spontaneous and IFN-gamma-induced GAG synthesis of REF was inhibited by Ptx (100, 500 and 1000 mg/l, respectively). Pentoxifylline 77-80 interferon gamma Homo sapiens 21-30 9286387-5 1997 The deficient IL-12 production by PGE2-DC was observed after stimulation both in the absence and in the presence of IFN gamma, and was not compensated during further 48 h culture in the absence of PGE2. Dinoprostone 34-38 interferon gamma Homo sapiens 116-125 9321950-0 1997 Regulation of eicosanoid-like compound biosynthesis by IFN-gamma, IL-6, and EPA in human breast cancer cell line. Eicosanoids 14-24 interferon gamma Homo sapiens 55-64 9330691-0 1997 The effect of anti-CD26 antibodies on DNA synthesis and cytokine production (IL-2, IL-10 and IFN-gamma) depends on enzymatic activity of DP IV/CD26. dp 137-139 interferon gamma Homo sapiens 93-102 9090449-4 1997 We have found previously that both ovine and human colostrinines are inducers of interferon (IFN) gamma and other cytokines. colostrinine 51-64 interferon gamma Homo sapiens 81-103 8978280-0 1997 Arachidonic acid mediates interferon-gamma-induced sphingomyelin hydrolysis and monocytic marker expression in HL-60 cell line. Arachidonic Acid 0-16 interferon gamma Homo sapiens 26-42 9191868-0 1997 AZT blocks down-regulation of IL-2 and IFN-gamma gene expression in HIV acutely infected cells. Zidovudine 0-3 interferon gamma Homo sapiens 39-48 9374379-0 1997 Cisplatin resistance is associated with reduced interferon-gamma-sensitivity and increased HER-2 expression in cultured ovarian carcinoma cells. Cisplatin 0-9 interferon gamma Homo sapiens 48-64 9055793-1 1997 The aim of this study was to assess neopterin, a marker of interferon gamma (IFN-gamma) induced macrophage activity, as a possible surrogate marker of inflammation in patients with multiple sclerosis. Neopterin 36-45 interferon gamma Homo sapiens 59-86 8978280-2 1997 Recent studies established the existence of a sphingomyelin (SM) cycle that operates in response to the action of IFN-gamma on HL-60 cells, but the mechanisms by which IFN-gamma induces the SM hydrolysis remain unexplored. Sphingomyelins 46-59 interferon gamma Homo sapiens 114-123 8978280-2 1997 Recent studies established the existence of a sphingomyelin (SM) cycle that operates in response to the action of IFN-gamma on HL-60 cells, but the mechanisms by which IFN-gamma induces the SM hydrolysis remain unexplored. Sphingomyelins 46-59 interferon gamma Homo sapiens 168-177 8978280-2 1997 Recent studies established the existence of a sphingomyelin (SM) cycle that operates in response to the action of IFN-gamma on HL-60 cells, but the mechanisms by which IFN-gamma induces the SM hydrolysis remain unexplored. Sphingomyelins 61-63 interferon gamma Homo sapiens 114-123 8978280-2 1997 Recent studies established the existence of a sphingomyelin (SM) cycle that operates in response to the action of IFN-gamma on HL-60 cells, but the mechanisms by which IFN-gamma induces the SM hydrolysis remain unexplored. Sphingomyelins 61-63 interferon gamma Homo sapiens 168-177 8978280-4 1997 The activation of the SM cycle by IFN-gamma occurred rapidly, with a decrease of approximately 20% in the SM level observed after 60 minutes with a concomitant increase in ceramide level. Ceramides 172-180 interferon gamma Homo sapiens 34-43 8978280-6 1997 IFN-gamma stimulated a rapid release of arachidonic acid (AA) from HL-60 cells; the effect was abolished by the pretreatment of cells with pertussis toxin, suggesting a role for a pertussis-toxin-sensitive G protein in IFN-gamma-mediated activation of phospholipase A2 (PLA2). Arachidonic Acid 40-56 interferon gamma Homo sapiens 0-9 8978280-6 1997 IFN-gamma stimulated a rapid release of arachidonic acid (AA) from HL-60 cells; the effect was abolished by the pretreatment of cells with pertussis toxin, suggesting a role for a pertussis-toxin-sensitive G protein in IFN-gamma-mediated activation of phospholipase A2 (PLA2). Arachidonic Acid 40-56 interferon gamma Homo sapiens 219-228 8978280-8 1997 The treatment of cells with tyrosine kinase inhibitor herbimycin A completely abolished the effect of IFN-gamma on PLA2 activity in membrane and cytosolic fractions, but had no effect on IFN-gamma-mediated early AA release suggesting dual mechanism of PLA2 activation. herbimycin 54-66 interferon gamma Homo sapiens 102-111 8978280-10 1997 Pretreatment of HL-60 cells with the PLA2 inhibitor, bromophenacyl bromide (BPB), or pertussis toxin abolished the effect of IFN-gamma on SM hydrolysis; exogenous addition of AA overcame the effects of BPB and pertussis toxin. 4-bromophenacyl bromide 53-74 interferon gamma Homo sapiens 125-134 8978280-10 1997 Pretreatment of HL-60 cells with the PLA2 inhibitor, bromophenacyl bromide (BPB), or pertussis toxin abolished the effect of IFN-gamma on SM hydrolysis; exogenous addition of AA overcame the effects of BPB and pertussis toxin. 4-bromophenacyl bromide 76-79 interferon gamma Homo sapiens 125-134 8978280-10 1997 Pretreatment of HL-60 cells with the PLA2 inhibitor, bromophenacyl bromide (BPB), or pertussis toxin abolished the effect of IFN-gamma on SM hydrolysis; exogenous addition of AA overcame the effects of BPB and pertussis toxin. 4-bromophenacyl bromide 202-205 interferon gamma Homo sapiens 125-134 8978280-11 1997 Long-term exposure (5 days) of HL-60 cells to IFN-gamma caused an increase in nitroblue tetrazolium (NBT)-reducing and nonspecific esterase (NSE) activity and induced expression of Fc gamma RI (CD64) without significant effects on cell number, adherence, or phagocytic activity. Tetrazolium Salts 88-99 interferon gamma Homo sapiens 46-55 8978280-11 1997 Long-term exposure (5 days) of HL-60 cells to IFN-gamma caused an increase in nitroblue tetrazolium (NBT)-reducing and nonspecific esterase (NSE) activity and induced expression of Fc gamma RI (CD64) without significant effects on cell number, adherence, or phagocytic activity. Nitroblue Tetrazolium 101-104 interferon gamma Homo sapiens 46-55 9020930-8 1997 Our results indicate that IFN-alpha potently suppresses the abnormal IL-4 and IL-5 production, that IL-12 can correct the deficient IFN-gamma production and cell-mediated cytotoxicity, and that retinoids can enhance IFN-gamma and IL-12 production. Retinoids 194-203 interferon gamma Homo sapiens 132-141 9094218-4 1997 Analysis of this peptide by MS indicated that the recombinant IFN-gamma polypeptide secreted by CHO cells was truncated by at least ten amino acids, initially at Gln133-Met134. cho 96-99 interferon gamma Homo sapiens 62-71 9094218-6 1997 Additional proteolytic cleavages at basic amino acids N-terminal of Gln133 occurred during the later stages of the culture resulting in a heterogeneous IFN-gamma polypeptide with "ragged" C-termini. Amino Acids, Basic 36-53 interferon gamma Homo sapiens 152-161 8977400-4 1997 In contrast bacterial endotoxin (lipopolysaccharide), interferon-gamma, or tumor necrosis factor-alpha, which are well known inducers of inducible NOS (iNOS) in a variety of immunocompetent and nonimmunocompetent cell types, failed to increase [3H]citrulline formation or NO2- accumulation in untreated or FSH-stimulated cells. Tritium 245-247 interferon gamma Homo sapiens 54-102 8977400-4 1997 In contrast bacterial endotoxin (lipopolysaccharide), interferon-gamma, or tumor necrosis factor-alpha, which are well known inducers of inducible NOS (iNOS) in a variety of immunocompetent and nonimmunocompetent cell types, failed to increase [3H]citrulline formation or NO2- accumulation in untreated or FSH-stimulated cells. Citrulline 248-258 interferon gamma Homo sapiens 54-102 8977400-4 1997 In contrast bacterial endotoxin (lipopolysaccharide), interferon-gamma, or tumor necrosis factor-alpha, which are well known inducers of inducible NOS (iNOS) in a variety of immunocompetent and nonimmunocompetent cell types, failed to increase [3H]citrulline formation or NO2- accumulation in untreated or FSH-stimulated cells. Nitrogen Dioxide 272-275 interferon gamma Homo sapiens 54-102 9020930-8 1997 Our results indicate that IFN-alpha potently suppresses the abnormal IL-4 and IL-5 production, that IL-12 can correct the deficient IFN-gamma production and cell-mediated cytotoxicity, and that retinoids can enhance IFN-gamma and IL-12 production. Retinoids 194-203 interferon gamma Homo sapiens 216-225 9021406-6 1997 The proliferative response and production of GM-CSF, TNF-alpha, and IFN-gamma by C27 were further augmented by replacing the possible first DR anchor 4Tyr of the mutated Ras peptide with Trp, a more potent anchor residue for the DR1 molecule. Tryptophan 187-190 interferon gamma Homo sapiens 68-77 8977230-0 1997 Beryllium induces IL-2 and IFN-gamma in berylliosis. Beryllium 0-9 interferon gamma Homo sapiens 27-36 8977230-3 1997 Our findings demonstrate that beryllium sulfate stimulates production of both IL-2 and IFN-gamma, not IL-4 and IL-7. beryllium sulfate 30-47 interferon gamma Homo sapiens 87-96 8977230-5 1997 Beryllium-stimulated T lymphocyte proliferation and IFN-gamma release were only partially inhibited by neutralization of IL-2. Beryllium 0-9 interferon gamma Homo sapiens 52-61 8977230-8 1997 We conclude that IL-2 and IFN-gamma are produced in the beryllium-stimulated, cell-mediated immune response with different time courses and that the alpha subunit of the soluble IL-2 receptor may serve as a biomarker of disease progression. Beryllium 56-65 interferon gamma Homo sapiens 26-35 8985206-2 1997 Recently, generation of nitrite in culture supernatants of human macrophages exposed to interferon-gamma and interleukin-4 (IFN-gamma/IL-4) was reported. Nitrites 24-31 interferon gamma Homo sapiens 88-104 8985206-2 1997 Recently, generation of nitrite in culture supernatants of human macrophages exposed to interferon-gamma and interleukin-4 (IFN-gamma/IL-4) was reported. Nitrites 24-31 interferon gamma Homo sapiens 124-133 8985206-8 1997 Nitrite accumulation in experiments with IFN-gamma/IL-4 in human monocytes appears to be an in vitro artifact produced by nitrate-reducing activities contained in cytokine preparations. Nitrites 0-7 interferon gamma Homo sapiens 41-50 8985206-8 1997 Nitrite accumulation in experiments with IFN-gamma/IL-4 in human monocytes appears to be an in vitro artifact produced by nitrate-reducing activities contained in cytokine preparations. Nitrates 122-129 interferon gamma Homo sapiens 41-50 8980289-5 1997 In experiments to investigate the role of protein tyrosine kinase (PTK) in C3 production, we found that treatment with herbimycin A, a specific inhibitor for the c-Src-related PTK, caused significant enhancement of the C3 production induced by IFNgamma or TNFalpha, suggesting that c-Src-type PTK(s) provides a negative signal to C3 production. herbimycin 119-131 interferon gamma Homo sapiens 244-252 8977191-7 1997 Furthermore, inhibition of CD28 expression mediated by one representative active oligonucleotide, GR1, resulted in a concomitant dose-dependent diminution of anti-CD3/PMA-induced cytokine (IL-2, IFN-gamma, IL-8) production. Oligonucleotides 81-96 interferon gamma Homo sapiens 195-204 8980289-6 1997 Each competitive inhibitor of PTK, genistein or tyrphostin, substantially increased the C3 production by IFNgamma at lower concentrations, although each agent had little effect on TNFalpha-associated production of C3 at the same concentrations. Genistein 35-44 interferon gamma Homo sapiens 105-113 8980289-6 1997 Each competitive inhibitor of PTK, genistein or tyrphostin, substantially increased the C3 production by IFNgamma at lower concentrations, although each agent had little effect on TNFalpha-associated production of C3 at the same concentrations. Tyrphostins 48-58 interferon gamma Homo sapiens 105-113 9002011-0 1997 Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells. Chloroquine 0-11 interferon gamma Homo sapiens 98-114 9002011-0 1997 Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells. Hydroxychloroquine 16-34 interferon gamma Homo sapiens 98-114 9002011-7 1997 RESULTS: We observed that chloroquine and hydroxychloroquine equally inhibit PHA induced TNF-alpha and IFN-gamma production, and LPS induced TNF-alpha and IL-6 production, while PHA induced IL-6 production was not affected. Chloroquine 26-37 interferon gamma Homo sapiens 103-112 9002011-7 1997 RESULTS: We observed that chloroquine and hydroxychloroquine equally inhibit PHA induced TNF-alpha and IFN-gamma production, and LPS induced TNF-alpha and IL-6 production, while PHA induced IL-6 production was not affected. Hydroxychloroquine 42-60 interferon gamma Homo sapiens 103-112 9010503-7 1997 While EPI or TRP induced higher production of IFN gamma specific message and low IL-10, anti-Id cells produced higher levels of IL-10 and low IFN gamma. Tryptophan 13-16 interferon gamma Homo sapiens 46-55 9010456-1 1997 In a murine model of rickettsial disease in which, as in human rickettsioses, endothelial cells are the major target of infection, depletion of IFN-gamma or TNF-alpha converts a sublethal infection into a uniformly fatal disease with overwhelming rickettsial growth and decreased nitric oxide (NO) synthesis. Nitric Oxide 280-292 interferon gamma Homo sapiens 144-153 8993464-10 1996 However, when VIP was added at 10(-6) and 10(-5) mol/L, a higher level of interferon gamma was found in the nickel-treated cell cultures compared to the controls. Nickel 108-114 interferon gamma Homo sapiens 74-90 8954998-7 1996 These data suggest that Fas may be one of the possible targets for a novel approach to human kidney cancer, and the efficiency of this Fas-mediated treatment for kidney cancer could be augmented by the treatment with interferon-gamma. ammonium ferrous sulfate 24-27 interferon gamma Homo sapiens 217-233 8954998-7 1996 These data suggest that Fas may be one of the possible targets for a novel approach to human kidney cancer, and the efficiency of this Fas-mediated treatment for kidney cancer could be augmented by the treatment with interferon-gamma. ammonium ferrous sulfate 135-138 interferon gamma Homo sapiens 217-233 8955104-5 1996 Interferon-gamma inhibits human monocyte/macrophage-facilitated LDL lipid peroxidation via induction of cellular tryptophan degradation and production and release of 3-hydroxyanthranilic acid (3HAA) (Christen, S., Thomas, S. R., Garner, B., and Stocker, R. (1994) J. Clin. Tryptophan 113-123 interferon gamma Homo sapiens 0-16 8955104-5 1996 Interferon-gamma inhibits human monocyte/macrophage-facilitated LDL lipid peroxidation via induction of cellular tryptophan degradation and production and release of 3-hydroxyanthranilic acid (3HAA) (Christen, S., Thomas, S. R., Garner, B., and Stocker, R. (1994) J. Clin. 3-Hydroxyanthranilic Acid 166-191 interferon gamma Homo sapiens 0-16 8955104-24 1996 Since interferon-gamma is the principal inducer of tryptophan degradation and release of 3HAA by monocytes/macrophages, this may represent a localized extracellular antioxidant defense against LDL oxidation in inflammation. Tryptophan 51-61 interferon gamma Homo sapiens 6-22 8955104-24 1996 Since interferon-gamma is the principal inducer of tryptophan degradation and release of 3HAA by monocytes/macrophages, this may represent a localized extracellular antioxidant defense against LDL oxidation in inflammation. 3-Hydroxyanthranilic Acid 89-93 interferon gamma Homo sapiens 6-22 8986769-1 1996 Interferon gamma (IFN-gamma) induces rapid tyrosine phosphorylation of the latent cytoplasmic transcription factor, Stat1, which then forms homodimers, translocates to the nucleus and participates in IFN-gamma-induced transcription. Tyrosine 43-51 interferon gamma Homo sapiens 0-27 9018097-0 1996 Vitamin D3 reduces the apoptotic effect of IFN-gamma but does not facilitate HLA class II inducibility in RB-defective cells. Cholecalciferol 0-10 interferon gamma Homo sapiens 43-52 8986769-1 1996 Interferon gamma (IFN-gamma) induces rapid tyrosine phosphorylation of the latent cytoplasmic transcription factor, Stat1, which then forms homodimers, translocates to the nucleus and participates in IFN-gamma-induced transcription. Tyrosine 43-51 interferon gamma Homo sapiens 18-27 9018097-6 1996 Our results indicated that cotreating the RB-defective S4 cells with IFN-gamma and Vitamin D3 decreased the number of cells containing subdiploid DNA compared to cells treated with IFN-gamma alone, suggesting that Vitamin D3 reduced IFN-gamma-mediated apoptosis. Cholecalciferol 214-224 interferon gamma Homo sapiens 69-78 9018097-6 1996 Our results indicated that cotreating the RB-defective S4 cells with IFN-gamma and Vitamin D3 decreased the number of cells containing subdiploid DNA compared to cells treated with IFN-gamma alone, suggesting that Vitamin D3 reduced IFN-gamma-mediated apoptosis. Cholecalciferol 214-224 interferon gamma Homo sapiens 181-190 9018097-6 1996 Our results indicated that cotreating the RB-defective S4 cells with IFN-gamma and Vitamin D3 decreased the number of cells containing subdiploid DNA compared to cells treated with IFN-gamma alone, suggesting that Vitamin D3 reduced IFN-gamma-mediated apoptosis. Cholecalciferol 214-224 interferon gamma Homo sapiens 181-190 9018097-7 1996 S4 cells cotreated with Vitamin D3 and IFN-gamma also had decreased cell detachment, further indicating that Vitamin D3 decreased IFN-gamma induced apoptosis. Cholecalciferol 24-34 interferon gamma Homo sapiens 130-139 9018097-7 1996 S4 cells cotreated with Vitamin D3 and IFN-gamma also had decreased cell detachment, further indicating that Vitamin D3 decreased IFN-gamma induced apoptosis. Cholecalciferol 109-119 interferon gamma Homo sapiens 39-48 9018097-7 1996 S4 cells cotreated with Vitamin D3 and IFN-gamma also had decreased cell detachment, further indicating that Vitamin D3 decreased IFN-gamma induced apoptosis. Cholecalciferol 109-119 interferon gamma Homo sapiens 130-139 8955209-4 1996 In contrast, PMA did not increase specific 125I-hC3a binding, and actually antagonized C3aR induction by IFN-gamma. Tetradecanoylphorbol Acetate 13-16 interferon gamma Homo sapiens 105-114 8986132-8 1996 Ebselen prevented the increase in nitrite production by human islets exposed for 14 hr to a combination of cytokines (IL-1 beta, tumor necrosis factor-alpha and interferon-gamma). ebselen 0-7 interferon gamma Homo sapiens 161-177 8955215-2 1996 While untreated THP-1 cells displayed little PLD response to the P2zR agonist 3"-O-(4-benzoyl)benzoyl (Bz)ATP, treatment with either IFN-gamma or bacterial LPS induced a BzATP-mediated stimulation of PLD activity. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 170-175 interferon gamma Homo sapiens 133-142 8955215-7 1996 IFN-gamma and LPS treatment also synergistically induced P2zR-dependent changes in membrane permeability and cytolysis, as indicated by BzATP-mediated Ca2+ influx, ethidium bromide uptake, and lactate dehydrogenase release. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 136-141 interferon gamma Homo sapiens 0-9 8955215-7 1996 IFN-gamma and LPS treatment also synergistically induced P2zR-dependent changes in membrane permeability and cytolysis, as indicated by BzATP-mediated Ca2+ influx, ethidium bromide uptake, and lactate dehydrogenase release. Ethidium 164-180 interferon gamma Homo sapiens 0-9 8955215-8 1996 Finally, IFN-gamma and LPS synergistically up-regulated mRNA encoding the P2X7 receptor, a recently cloned ATP-gated channel that exhibits a P2zR phenotype. Adenosine Triphosphate 107-110 interferon gamma Homo sapiens 9-18 8943243-7 1996 The CpG dinucleotide in this element is selectively methylated in Th2 T cells and other cells that do not express IFN-gamma, and methylation markedly reduces transcription factor binding. cytidylyl-3'-5'-guanosine 4-20 interferon gamma Homo sapiens 114-123 8986132-8 1996 Ebselen prevented the increase in nitrite production by human islets exposed for 14 hr to a combination of cytokines (IL-1 beta, tumor necrosis factor-alpha and interferon-gamma). Nitrites 34-41 interferon gamma Homo sapiens 161-177 8940092-3 1996 Using this system, we found that Stat1 is actively transported through the nuclear pores in an IFN-gamma-dependent manner and tyrosine (Tyr701) phosphorylation of Stat1 is actually required for its nuclear import. Tyrosine 126-134 interferon gamma Homo sapiens 95-104 8940176-7 1996 Salicylate also inhibited interferon-gamma plus interleukin-1beta-induced NOS 2 mRNA. Salicylates 0-10 interferon gamma Homo sapiens 26-42 8954078-2 1996 In this study we show that in the U937 monoblastic leukemia cell line, pretreatment with IFN-gamma enhanced sensitivity to apoptosis triggered by gamma-irradiation or antitumor agents (etoposide or adriamycin), as well as by anti-Fas antibody. Etoposide 185-194 interferon gamma Homo sapiens 89-98 8954078-2 1996 In this study we show that in the U937 monoblastic leukemia cell line, pretreatment with IFN-gamma enhanced sensitivity to apoptosis triggered by gamma-irradiation or antitumor agents (etoposide or adriamycin), as well as by anti-Fas antibody. Doxorubicin 198-208 interferon gamma Homo sapiens 89-98 8973572-6 1996 Interferon gamma, an inducer of indoleamine 2,3-dioxygenase, increased the accumulation of L-kynurenine by all three cell types (to more than 40 microM). Kynurenine 91-103 interferon gamma Homo sapiens 0-16 8954910-3 1996 Pre-treatment of macrophages with LPS, IFN-gamma in the presence of NG-monomethyl-L-arginine (NMMA) imparts resistance to apoptotic cell death, normally elicited by exogenously-supplied GSNO. omega-N-Methylarginine 94-98 interferon gamma Homo sapiens 39-48 8954910-3 1996 Pre-treatment of macrophages with LPS, IFN-gamma in the presence of NG-monomethyl-L-arginine (NMMA) imparts resistance to apoptotic cell death, normally elicited by exogenously-supplied GSNO. S-Nitrosoglutathione 186-190 interferon gamma Homo sapiens 39-48 9177819-4 1996 The maintained antigen presenting ability of adherent cells treated with IFN-gamma was also suppressed by Ketotifen. Ketotifen 106-115 interferon gamma Homo sapiens 73-82 9177819-5 1996 Fluorescence activated cell sorter (FACS) analysis disclosed that Ketotifen selectively reduced the expression of HLA-DQ antigen, crucial restriction elements in Df antigen-related responses, on macrophages but not on B cells, even in the presence of IFN-gamma. Ketotifen 66-75 interferon gamma Homo sapiens 251-260 10851495-1 1996 We investigated whether the biological response modifiers like IFN-alpha, IFN-gamma and TNF-alpha could enhance the cytotoxic action of cisplatin on cervical carcinoma cell lines in vitro. Cisplatin 136-145 interferon gamma Homo sapiens 74-83 8959347-6 1996 We also show that MRP-8 expression is retinoid inhibitable in cultured keratinocytes induced to differentiate with 10% serum or IFN-gamma, and that MRP-8 is inhibited by RAR but not by retinoid X receptor-specific retinoids in a dose-dependent manner. Retinoids 38-46 interferon gamma Homo sapiens 128-137 8981094-1 1996 We studied changes in the carbohydrate expression following apoptotic cell death induced by treatment with interferon (IFN)-gamma and anti-Fas antibody using human colon adenocarcinoma HT-29 cells. Carbohydrates 26-38 interferon gamma Homo sapiens 107-129 8973632-0 1996 Biosynthesis and N-glycosylation of human interferon-gamma. Nitrogen 17-18 interferon gamma Homo sapiens 42-58 8973632-7 1996 Inhibition of N-glycosylation by tunicamycin dramatically reduced the expression of IFN-gamma, but did not block its secretion. Nitrogen 14-15 interferon gamma Homo sapiens 84-93 8973632-7 1996 Inhibition of N-glycosylation by tunicamycin dramatically reduced the expression of IFN-gamma, but did not block its secretion. Tunicamycin 33-44 interferon gamma Homo sapiens 84-93 8973632-10 1996 Site-specific oligosaccharide analysis of natural IFN-gamma by glycosidase treatment followed by matrix-assisted-laser-desorption-ionization mass spectrometry revealed considerable variation in the carbohydrate structures, with more than 30 different forms. Oligosaccharides 14-29 interferon gamma Homo sapiens 50-59 8973632-10 1996 Site-specific oligosaccharide analysis of natural IFN-gamma by glycosidase treatment followed by matrix-assisted-laser-desorption-ionization mass spectrometry revealed considerable variation in the carbohydrate structures, with more than 30 different forms. Carbohydrates 198-210 interferon gamma Homo sapiens 50-59 9014816-8 1996 However, interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) mRNAs were detected in the control reinfected animals on days 3 and/or 9 after reinfection but not on these days in animals undergoing treatment with CsA. Cyclosporine 213-216 interferon gamma Homo sapiens 34-50 9014816-8 1996 However, interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) mRNAs were detected in the control reinfected animals on days 3 and/or 9 after reinfection but not on these days in animals undergoing treatment with CsA. Cyclosporine 213-216 interferon gamma Homo sapiens 52-61 9014819-0 1996 Interferon-gamma promotes the survival and Fc epsilon RI-mediated histamine release in cultured human mast cells. Histamine 66-75 interferon gamma Homo sapiens 0-16 9014819-5 1996 When mast cells were incubated with IFN-gamma in serum-free medium for more than 4 hr during sensitization, immunoglobulin E (IgE)/anti-IgE antibody-induced histamine release was effectively enhanced. Histamine 157-166 interferon gamma Homo sapiens 36-45 8977524-4 1996 The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187. herbimycin 30-40 interferon gamma Homo sapiens 69-85 8977524-4 1996 The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187. herbimycin 30-40 interferon gamma Homo sapiens 87-96 8953156-8 1996 Titanium did not alter IFN-gamma production, whereas chromium and cobalt significantly reduced IFN-gamma release by PHA-stimulated PBMC. Chromium 53-61 interferon gamma Homo sapiens 95-104 8977524-4 1996 The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187. Tetradecanoylphorbol Acetate 192-223 interferon gamma Homo sapiens 69-85 8977524-4 1996 The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187. Tetradecanoylphorbol Acetate 192-223 interferon gamma Homo sapiens 87-96 8977524-4 1996 The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187. Tetradecanoylphorbol Acetate 225-228 interferon gamma Homo sapiens 69-85 8977524-4 1996 The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187. Tetradecanoylphorbol Acetate 225-228 interferon gamma Homo sapiens 87-96 8977524-4 1996 The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187. Calcium 238-245 interferon gamma Homo sapiens 69-85 8977524-4 1996 The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187. Calcium 238-245 interferon gamma Homo sapiens 87-96 8977524-4 1996 The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187. Calcimycin 256-262 interferon gamma Homo sapiens 69-85 8977524-4 1996 The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187. Calcimycin 256-262 interferon gamma Homo sapiens 87-96 8977524-6 1996 Cyclosporin A inhibited the proliferation as well as the production of the cytokines, including that of IL-2, IL-4, IL-5, and IFN-gamma, irrespective of the mode of stimulation. Cyclosporine 0-13 interferon gamma Homo sapiens 126-135 8977524-7 1996 A23187, which synergizes with PMA in the induction of IL-4 and IFN-gamma, inhibited PMA-induced IL-10 production in a dose-dependent manner. Calcimycin 0-6 interferon gamma Homo sapiens 63-72 8977524-7 1996 A23187, which synergizes with PMA in the induction of IL-4 and IFN-gamma, inhibited PMA-induced IL-10 production in a dose-dependent manner. Tetradecanoylphorbol Acetate 30-33 interferon gamma Homo sapiens 63-72 8977524-7 1996 A23187, which synergizes with PMA in the induction of IL-4 and IFN-gamma, inhibited PMA-induced IL-10 production in a dose-dependent manner. Tetradecanoylphorbol Acetate 84-87 interferon gamma Homo sapiens 63-72 8953156-8 1996 Titanium did not alter IFN-gamma production, whereas chromium and cobalt significantly reduced IFN-gamma release by PHA-stimulated PBMC. Cobalt 66-72 interferon gamma Homo sapiens 95-104 8974009-1 1996 In the presence of interferon-gamma (IFN-gamma), human tumor necrosis factor-alpha (Hu-TNF-alpha), which binds to murine TNF-alpha receptor type 1 (TNF-R1) but not to murine TNF-R2, was effective in inducing nitric oxide (NO) production in spleen-derived macrophages (M phi), albeit at concentrations 12.5-fold greater than those required by murine TNF-alpha (Mu-TNF-alpha), to achieve the same result. Nitric Oxide 208-220 interferon gamma Homo sapiens 19-35 8974009-1 1996 In the presence of interferon-gamma (IFN-gamma), human tumor necrosis factor-alpha (Hu-TNF-alpha), which binds to murine TNF-alpha receptor type 1 (TNF-R1) but not to murine TNF-R2, was effective in inducing nitric oxide (NO) production in spleen-derived macrophages (M phi), albeit at concentrations 12.5-fold greater than those required by murine TNF-alpha (Mu-TNF-alpha), to achieve the same result. Nitric Oxide 208-220 interferon gamma Homo sapiens 37-46 8975882-1 1996 Interferon-gamma (IFN-gamma), vitamin D3 (VD), and retinoic acid (RA) induce differentiation of human monoblastic leukemia U937 cells to macrophage-like cells with potential superoxide anion-generating activity upon further stimulation. Tretinoin 66-68 interferon gamma Homo sapiens 0-16 8975882-1 1996 Interferon-gamma (IFN-gamma), vitamin D3 (VD), and retinoic acid (RA) induce differentiation of human monoblastic leukemia U937 cells to macrophage-like cells with potential superoxide anion-generating activity upon further stimulation. Tretinoin 66-68 interferon gamma Homo sapiens 18-27 8975882-1 1996 Interferon-gamma (IFN-gamma), vitamin D3 (VD), and retinoic acid (RA) induce differentiation of human monoblastic leukemia U937 cells to macrophage-like cells with potential superoxide anion-generating activity upon further stimulation. Superoxides 174-190 interferon gamma Homo sapiens 0-16 8975882-1 1996 Interferon-gamma (IFN-gamma), vitamin D3 (VD), and retinoic acid (RA) induce differentiation of human monoblastic leukemia U937 cells to macrophage-like cells with potential superoxide anion-generating activity upon further stimulation. Superoxides 174-190 interferon gamma Homo sapiens 18-27 8982105-7 1996 SP reverses the inhibitory effect of IFN-gamma on LPS-induced IL-10 secretion by FICBM. sp 0-2 interferon gamma Homo sapiens 37-46 8982097-3 1996 To better understand the immunopathology of brain injury, we studied the role of inflammatory cytokines such as tumor necrosis factor alpha, interleukin (IL) 6, IL-2, interferon gamma and IL-1 beta in the production of arachidonic acid metabolites in cells from fetal human brain. Arachidonic Acid 219-235 interferon gamma Homo sapiens 167-183 8958270-12 1996 During the second week of acute steroid-resistant rejection and lethal infection, a significant rise in IL-1beta, IFN-gamma, and IL-6 was observed (P < or = 0.01 versus control groups). Steroids 32-39 interferon gamma Homo sapiens 114-123 8972749-2 1996 Glutamine had no effect on the production of interleukin-1 beta, interleukin-6 or tumour necrosis factor-alpha, but influenced the production of interleukin-2 and interferon-gamma. Glutamine 0-9 interferon gamma Homo sapiens 163-179 8950996-1 1996 Adult T-cell leukemia is associated with high levels of neopterin, released in large amounts from human macrophages upon stimulation with interferon-gamma. Neopterin 56-65 interferon gamma Homo sapiens 138-154 8947049-1 1996 After interferon-gamma (IFN-gamma) treatment of cells the appearance of tyrosine phosphorylated Stat1 in the nucleus was maximal within 20-30 min, remained for 2-2.5 h and activated molecules disappeared by 4 h. In the absence of continued signaling from the receptor (imposed by staurosporine treatment) previously activated Stat1 disappeared completely within 60 min, implying continuous generation and removal of active molecules during extended IFN-gamma treatment. Tyrosine 72-80 interferon gamma Homo sapiens 6-22 8910607-1 1996 In this report, we demonstrate that insulin receptor substrate-2 (IRS-2) is tyrosyl-phosphorylated following stimulation of 3T3-F442A fibroblasts with growth hormone (GH), leukemia inhibitory factor and interferon-gamma. cyclo(tyrosyl-tyrosyl) 76-83 interferon gamma Homo sapiens 203-219 8910607-3 1996 In response to interferon-gamma, tyrosine phosphorylation of IRS-2 was prolonged, with substantial signal still detected at 60 min. Tyrosine 33-41 interferon gamma Homo sapiens 15-31 8945627-3 1996 While MCF7 and R-A1 cells were killed by anti-Fas in the presence of IFN-gamma, MCF7Adr was found to be resistant to Fas-mediated apoptosis. ammonium ferrous sulfate 46-49 interferon gamma Homo sapiens 69-78 8947049-1 1996 After interferon-gamma (IFN-gamma) treatment of cells the appearance of tyrosine phosphorylated Stat1 in the nucleus was maximal within 20-30 min, remained for 2-2.5 h and activated molecules disappeared by 4 h. In the absence of continued signaling from the receptor (imposed by staurosporine treatment) previously activated Stat1 disappeared completely within 60 min, implying continuous generation and removal of active molecules during extended IFN-gamma treatment. Tyrosine 72-80 interferon gamma Homo sapiens 24-33 8947049-1 1996 After interferon-gamma (IFN-gamma) treatment of cells the appearance of tyrosine phosphorylated Stat1 in the nucleus was maximal within 20-30 min, remained for 2-2.5 h and activated molecules disappeared by 4 h. In the absence of continued signaling from the receptor (imposed by staurosporine treatment) previously activated Stat1 disappeared completely within 60 min, implying continuous generation and removal of active molecules during extended IFN-gamma treatment. Tyrosine 72-80 interferon gamma Homo sapiens 449-458 8947049-1 1996 After interferon-gamma (IFN-gamma) treatment of cells the appearance of tyrosine phosphorylated Stat1 in the nucleus was maximal within 20-30 min, remained for 2-2.5 h and activated molecules disappeared by 4 h. In the absence of continued signaling from the receptor (imposed by staurosporine treatment) previously activated Stat1 disappeared completely within 60 min, implying continuous generation and removal of active molecules during extended IFN-gamma treatment. Staurosporine 280-293 interferon gamma Homo sapiens 6-22 8947049-1 1996 After interferon-gamma (IFN-gamma) treatment of cells the appearance of tyrosine phosphorylated Stat1 in the nucleus was maximal within 20-30 min, remained for 2-2.5 h and activated molecules disappeared by 4 h. In the absence of continued signaling from the receptor (imposed by staurosporine treatment) previously activated Stat1 disappeared completely within 60 min, implying continuous generation and removal of active molecules during extended IFN-gamma treatment. Staurosporine 280-293 interferon gamma Homo sapiens 24-33 8910434-6 1996 The induction of IRF-1 mRNA by IFN-gamma in HT-29 cells reaches a maximum at 6 h and is superinduced by cycloheximide. Cycloheximide 104-117 interferon gamma Homo sapiens 31-40 8932275-0 1996 An oligonucleotide blocks interferon-gamma signal transduction. Oligonucleotides 3-18 interferon gamma Homo sapiens 26-42 8932275-3 1996 Oligonucleotide 5"-GGG GTT GGT TGT GTT GGG TGT TGT GT-RNH2 (oligo I) blocks multiple IFN-gamma effects in human K562 cell cultures. Oligonucleotides 0-15 interferon gamma Homo sapiens 85-94 8946016-0 1996 A nitric oxide production bioassay for interferon-gamma. Nitric Oxide 2-14 interferon gamma Homo sapiens 39-55 8910434-7 1996 Four mRNA species for BGP are induced by IFN-gamma, the major band of which is inhibited by cycloheximide. Cycloheximide 92-105 interferon gamma Homo sapiens 41-50 8946016-3 1996 We have developed a new bioassay for IFN-gamma which measures the concentration of nitric oxide (NO) generated by a macrophage cell line RAW264.7 stimulated with IFN-gamma. Nitric Oxide 83-95 interferon gamma Homo sapiens 37-46 8946016-3 1996 We have developed a new bioassay for IFN-gamma which measures the concentration of nitric oxide (NO) generated by a macrophage cell line RAW264.7 stimulated with IFN-gamma. Nitric Oxide 83-95 interferon gamma Homo sapiens 162-171 8977675-0 1996 Ethanol enhances the IFN-gamma, TGF-alpha and IL-6 secretion in psoriatic co-cultures. Ethanol 0-7 interferon gamma Homo sapiens 21-30 8937711-12 1996 Addition of 2-amino-4-methylpyridine at the same time as the LPS and IFN-gamma, dose-dependently reduced the levels of nitrite (IC50 = 1.5 microM) without affecting the induction of NOS II protein. 2-amino-4-picoline 12-36 interferon gamma Homo sapiens 69-78 8937711-12 1996 Addition of 2-amino-4-methylpyridine at the same time as the LPS and IFN-gamma, dose-dependently reduced the levels of nitrite (IC50 = 1.5 microM) without affecting the induction of NOS II protein. Nitrites 119-126 interferon gamma Homo sapiens 69-78 8977675-6 1996 TGF-alpha and IFN-gamma levels were elevated in the ethanol-treated psoriatic co-cultures, to 150% and 175% respectively, but neither in co-cultures with keratinocytes derived from healthy control individuals nor in monocultures. Ethanol 52-59 interferon gamma Homo sapiens 14-23 8912880-7 1996 Our results show that the decline in NK cell response to poly(I:C) and LPS in aged animals was correlated with decreased expression of the IFN-gamma gene. poly 57-61 interferon gamma Homo sapiens 139-148 8930418-5 1996 There was a significant correlation with in vitro IFN-gamma release, the absolute blood monocyte count and the serum neopterin levels, suggesting that monocytes stimulated by IFN-gamma play an important role in the TNF-alpha production. Neopterin 117-126 interferon gamma Homo sapiens 175-184 8917026-8 1996 Also, the mitogen-stimulated interferon-gamma production increased from 121 to 269 pg/mL (p < .05) in patients treated with ranitidine, but not in patients treated with placebo. Ranitidine 127-137 interferon gamma Homo sapiens 29-45 8921966-3 1996 We investigated a dexamethasone (Dex)-inducible monocyte subtype and its adhesion to either unstimulated or lipopolysaccharide (LPS)- or interferon (IFN)-gamma-stimulated human umbilical vein endothelial cells (HUVEC). Dexamethasone 18-31 interferon gamma Homo sapiens 137-159 8921966-3 1996 We investigated a dexamethasone (Dex)-inducible monocyte subtype and its adhesion to either unstimulated or lipopolysaccharide (LPS)- or interferon (IFN)-gamma-stimulated human umbilical vein endothelial cells (HUVEC). Dexamethasone 33-36 interferon gamma Homo sapiens 137-159 8938544-8 1996 The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1. Staurosporine 31-44 interferon gamma Homo sapiens 314-360 8938544-8 1996 The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1. Tetradecanoylphorbol Acetate 109-140 interferon gamma Homo sapiens 314-360 8938544-8 1996 The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1. Staurosporine 249-262 interferon gamma Homo sapiens 314-360 8938568-4 1996 However, when present on both sides of the micropore membrane, all the IFN (1000 U/ml IFN-alpha and IFN-beta, 100 U/ml IFN-gamma) inhibited both random and directed migration toward zymosan-activated serum (ZAS). Zymosan 182-189 interferon gamma Homo sapiens 119-128 8938568-10 1996 In fact, inhibition of tyrosine kinase with herbimycin A increased the ZAS-stimulated motility of both control and IFN-gamma-inhibited PMN. herbimycin 44-56 interferon gamma Homo sapiens 115-124 8981304-5 1996 rIFNA therapy was associated with reduction of interferon-gamma and tumor necrosis factor-alpha production by PB lymphocytes (p < 0.04), and with slight, not significant, increase of transforming growth factor-beta 2 or interleukin (IL)-10 production. rifna 0-5 interferon gamma Homo sapiens 47-95 8938568-10 1996 In fact, inhibition of tyrosine kinase with herbimycin A increased the ZAS-stimulated motility of both control and IFN-gamma-inhibited PMN. ZAS 71-74 interferon gamma Homo sapiens 115-124 8863487-1 1996 We have previously reported that the polysialoganglioside GT1b suppresses the induction of major histocompatibility complex class I molecules by interferon-gamma in astrocytes. trisialoganglioside GT1 37-57 interferon gamma Homo sapiens 145-161 8937348-0 1996 Interferon-gamma activated calcium influx in peripheral blood lymphocytes from patients with primary and secondary progressive multiple sclerosis. Calcium 27-34 interferon gamma Homo sapiens 0-16 8937348-1 1996 Interferon-gamma (IFN-gamma) contributes to the early events leading to T cell activation in relapsing-remitting (RR) multiple sclerosis (MS) by activating a transplasmalemma calcium influx, the detection of which is closely associated with clinical and MRI evidence of disease activity. Calcium 175-182 interferon gamma Homo sapiens 0-16 8937348-1 1996 Interferon-gamma (IFN-gamma) contributes to the early events leading to T cell activation in relapsing-remitting (RR) multiple sclerosis (MS) by activating a transplasmalemma calcium influx, the detection of which is closely associated with clinical and MRI evidence of disease activity. Calcium 175-182 interferon gamma Homo sapiens 18-27 8937348-3 1996 It is still questioned whether the same immune mediated mechanisms also operate in primary progressive (PP)MS. Fluorimetric evidence of the IFN-gamma activated calcium influx was sought in 16 patients with PPMS and 39 patients with secondary progressive (SP)MS. To compare peripheral versus CNS evidence of immune activation 11 of the patients with PPMS and 27 of the patients with SPMS underwent gadolinium enhanced brain MRI. Calcium 160-167 interferon gamma Homo sapiens 140-149 8958948-0 1996 Retinoids synergize with IL-2 to increase interferon-gamma production by peripheral blood mononuclear cells via induction of IL-12. Retinoids 0-9 interferon gamma Homo sapiens 42-58 8958951-0 1996 Accessory cell-derived interleukin-12 and prostaglandin E2 determine the level of interferon-gamma produced by activated human CD4+ T cells. Dinoprostone 42-58 interferon gamma Homo sapiens 82-98 8900159-0 1996 Retinoic acid-induced transcriptional modulation of the human interferon-gamma promoter. Tretinoin 0-13 interferon gamma Homo sapiens 62-78 8900159-8 1996 These results suggest that direct modulation of IFN-gamma promoter activity is one of the possible mechanisms involved in the inhibitory effect of retinoids on IFN-gamma gene expression. Retinoids 147-156 interferon gamma Homo sapiens 48-57 8900159-1 1996 Disregulation of vitamin A metabolism is able to generate different immunological effects, including altered response to infection, reduced IgG production, and differential regulation of cytokine gene expression (including interleukin-2 and -4 and interferon-gamma (IFN-gamma)). Vitamin A 17-26 interferon gamma Homo sapiens 248-264 8900159-8 1996 These results suggest that direct modulation of IFN-gamma promoter activity is one of the possible mechanisms involved in the inhibitory effect of retinoids on IFN-gamma gene expression. Retinoids 147-156 interferon gamma Homo sapiens 160-169 8900159-1 1996 Disregulation of vitamin A metabolism is able to generate different immunological effects, including altered response to infection, reduced IgG production, and differential regulation of cytokine gene expression (including interleukin-2 and -4 and interferon-gamma (IFN-gamma)). Vitamin A 17-26 interferon gamma Homo sapiens 266-275 8900159-2 1996 In particular, IFN-gamma gene expression is significantly affected by vitamin A and/or its derivatives (e.g. retinoic acid (RA)). Vitamin A 70-79 interferon gamma Homo sapiens 15-24 8900159-2 1996 In particular, IFN-gamma gene expression is significantly affected by vitamin A and/or its derivatives (e.g. retinoic acid (RA)). Tretinoin 109-122 interferon gamma Homo sapiens 15-24 8900159-2 1996 In particular, IFN-gamma gene expression is significantly affected by vitamin A and/or its derivatives (e.g. retinoic acid (RA)). Tretinoin 124-126 interferon gamma Homo sapiens 15-24 8900159-3 1996 Here, we analyze the effect of retinoic acid on IFN-gamma transcription. Tretinoin 31-44 interferon gamma Homo sapiens 48-57 8900159-4 1996 Transient transfection assays in the human T lymphoblastoid cell line Jurkat demonstrated that the activation of the IFN-gamma promoter was significantly down-regulated in the presence of RA. Tretinoin 188-190 interferon gamma Homo sapiens 117-126 8878389-5 1996 The analyses showed that an increase in IFN-gamma and neopterin serum levels was a specific feature of cyclophosphamide administration and was not observed after other cytostatic drugs or total body irradiation, and that an increase in IFN-gamma, neopterin, beta2-microglobulin, and IFN-alpha release depends on the presence of T cells in the graft. Cyclophosphamide 103-119 interferon gamma Homo sapiens 40-49 8841000-5 1996 Four of five Fas-resistant breast cancer cell lines became sensitive to Fas-mediated apoptosis upon treatment with IFN-gamma. ammonium ferrous sulfate 13-16 interferon gamma Homo sapiens 115-124 8841000-6 1996 Fas mRNA increased slightly in both cell lines that became sensitive and in the cell line that remained resistant to Fas-mediated apoptosis upon IFN-gamma treatment. ammonium ferrous sulfate 0-3 interferon gamma Homo sapiens 145-154 8841000-10 1996 Fas sensitivity was reconstituted in the IFN-gamma-resistant cell line by transfection of ICE into that cell line. ammonium ferrous sulfate 0-3 interferon gamma Homo sapiens 41-50 8876196-7 1996 In mammalian cells treated with either erythropoietin or interferon-gamma, a small fraction of Raf-1 coimmunoprecipitated with JAK2 in lysates of cells in which JAK2 was activated as judged by its state of tyrosine phosphorylation. Tyrosine 206-214 interferon gamma Homo sapiens 57-73 8878389-5 1996 The analyses showed that an increase in IFN-gamma and neopterin serum levels was a specific feature of cyclophosphamide administration and was not observed after other cytostatic drugs or total body irradiation, and that an increase in IFN-gamma, neopterin, beta2-microglobulin, and IFN-alpha release depends on the presence of T cells in the graft. Neopterin 247-256 interferon gamma Homo sapiens 40-49 9181114-2 1996 The results, reported as mean +/- SEM cpm, showed that IFN-gamma induced a significant increase only in the IP3 level (N + medium = 1,413 +/- 172 and N + IFN-gamma = 8,875 +/- 832). Inositol 1,4,5-Trisphosphate 108-111 interferon gamma Homo sapiens 55-64 8897832-0 1996 Potentiation by thyroxine of interferon-gamma-induced antiviral state requires PKA and PKC activities. Thyroxine 16-25 interferon gamma Homo sapiens 29-45 8897832-1 1996 Added to HeLa cells previously exposed to recombinant human interferon (IFN)-gamma for 20 h, thyroid hormone [L-thyroxine (T4)] in physiological concentrations potentiates the antiviral action of IFN-gamma by more than 100-fold in 4 h. We examined protein kinase activities for their contributions to the mechanism of this posttranslational effect of thyroid hormone. Thyroxine 110-121 interferon gamma Homo sapiens 196-205 8897832-2 1996 Added concurrently with thyroid hormone, the protein kinase C (PKC) inhibitor CGP-41251 (5 nM) blocked T4 potentiation of IFN-gamma action. midostaurin 78-87 interferon gamma Homo sapiens 122-131 8870699-2 1996 IFN-gamma was detected in the culture supernatants of all of 36 PPD-specific TCL established from healthy controls, whereas only 24 of 38 PPD-specific TCL from patients produced IFN-gamma. Triclosan 77-80 interferon gamma Homo sapiens 0-9 8913279-3 1996 Interferon-gamma is a well known stimulus for THP-1 cells inducing e.g. neopterin production and tryptophan degradation. Neopterin 72-81 interferon gamma Homo sapiens 0-16 8913279-3 1996 Interferon-gamma is a well known stimulus for THP-1 cells inducing e.g. neopterin production and tryptophan degradation. Tryptophan 97-107 interferon gamma Homo sapiens 0-16 8913279-4 1996 Treatment of cells with 50 micrograms/ml 90K induced significant neopterin formation, and the exposure of cells to 90K in addition to 100 U/ml interferon-gamma amplified neopterin production compared to the sole effect of interferon-gamma. Neopterin 170-179 interferon gamma Homo sapiens 143-159 8913279-6 1996 When the cells were treated with the combination of 90K and interferon-gamma the degradation of tryptophan was further enhanced. Tryptophan 96-106 interferon gamma Homo sapiens 60-76 8870699-5 1996 The amounts of IL-4 production from Df-specific TCL from atopic patients were much higher than from healthy controls, while few TCL produced IFN-gamma. Triclosan 128-131 interferon gamma Homo sapiens 141-150 8870699-7 1996 Activation of PPD-specific TCL from patients with calcium ionophore A23187 plus phorbol myristate acetate resulted in much higher IFN-gamma production than in TCL established from healthy controls, indicating that the low production of IFN-gamma by PPD-specific T cells from atopic patients is not due to an intrinsic T cell defect but to some regulatory mechanisms. Triclosan 27-30 interferon gamma Homo sapiens 130-139 8870699-7 1996 Activation of PPD-specific TCL from patients with calcium ionophore A23187 plus phorbol myristate acetate resulted in much higher IFN-gamma production than in TCL established from healthy controls, indicating that the low production of IFN-gamma by PPD-specific T cells from atopic patients is not due to an intrinsic T cell defect but to some regulatory mechanisms. Triclosan 27-30 interferon gamma Homo sapiens 236-245 8870699-7 1996 Activation of PPD-specific TCL from patients with calcium ionophore A23187 plus phorbol myristate acetate resulted in much higher IFN-gamma production than in TCL established from healthy controls, indicating that the low production of IFN-gamma by PPD-specific T cells from atopic patients is not due to an intrinsic T cell defect but to some regulatory mechanisms. Calcimycin 68-74 interferon gamma Homo sapiens 130-139 8870699-7 1996 Activation of PPD-specific TCL from patients with calcium ionophore A23187 plus phorbol myristate acetate resulted in much higher IFN-gamma production than in TCL established from healthy controls, indicating that the low production of IFN-gamma by PPD-specific T cells from atopic patients is not due to an intrinsic T cell defect but to some regulatory mechanisms. Calcimycin 68-74 interferon gamma Homo sapiens 236-245 8870699-7 1996 Activation of PPD-specific TCL from patients with calcium ionophore A23187 plus phorbol myristate acetate resulted in much higher IFN-gamma production than in TCL established from healthy controls, indicating that the low production of IFN-gamma by PPD-specific T cells from atopic patients is not due to an intrinsic T cell defect but to some regulatory mechanisms. Tetradecanoylphorbol Acetate 80-105 interferon gamma Homo sapiens 130-139 8870699-7 1996 Activation of PPD-specific TCL from patients with calcium ionophore A23187 plus phorbol myristate acetate resulted in much higher IFN-gamma production than in TCL established from healthy controls, indicating that the low production of IFN-gamma by PPD-specific T cells from atopic patients is not due to an intrinsic T cell defect but to some regulatory mechanisms. Tetradecanoylphorbol Acetate 80-105 interferon gamma Homo sapiens 236-245 8933043-4 1996 We observed the beryllium-stimulated release of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-2 (IL-2), and interferon-gamma (IFN-gamma) but not interleukin-4 (IL-4). Beryllium 16-25 interferon gamma Homo sapiens 137-153 8930457-13 1996 Following preoperative (mean 5.09 h) administration of glucocorticosteroids, mitogenic cytokine induction (IL-1 beta, IL-2, sIL-2R and IFN-gamma) was almost completely blocked at the time of transplantation. glucocorticosteroids 55-75 interferon gamma Homo sapiens 135-144 8980883-0 1996 Differential suppression of dialysis patients" lymphocyte IFN-gamma production by glucocorticoids and cyclosporine. Cyclosporine 102-114 interferon gamma Homo sapiens 58-67 8980883-2 1996 Having previously demonstrated differential suppressive effects of methylprednisolone (MP), prednisolone (P) and cyclosporine (CsA) on dialysis patients" lymphocyte proliferative responses to phytohaemagglutinin (PHA), we studied the effects of these drugs on dialysis patients" lymphocyte IFN-gamma production during mitogenic and allogeneic (MLR) stimulation. Methylprednisolone 67-85 interferon gamma Homo sapiens 290-299 8980883-2 1996 Having previously demonstrated differential suppressive effects of methylprednisolone (MP), prednisolone (P) and cyclosporine (CsA) on dialysis patients" lymphocyte proliferative responses to phytohaemagglutinin (PHA), we studied the effects of these drugs on dialysis patients" lymphocyte IFN-gamma production during mitogenic and allogeneic (MLR) stimulation. Methylprednisolone 87-89 interferon gamma Homo sapiens 290-299 8980883-2 1996 Having previously demonstrated differential suppressive effects of methylprednisolone (MP), prednisolone (P) and cyclosporine (CsA) on dialysis patients" lymphocyte proliferative responses to phytohaemagglutinin (PHA), we studied the effects of these drugs on dialysis patients" lymphocyte IFN-gamma production during mitogenic and allogeneic (MLR) stimulation. Cyclosporine 113-125 interferon gamma Homo sapiens 290-299 8933043-4 1996 We observed the beryllium-stimulated release of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-2 (IL-2), and interferon-gamma (IFN-gamma) but not interleukin-4 (IL-4). Beryllium 16-25 interferon gamma Homo sapiens 155-164 8933043-5 1996 Beryllium-stimulated IFN-gamma release was sustained to 168 hr in culture, whereas IL-2 concentrations returned to baseline after 24 hr. Beryllium 0-9 interferon gamma Homo sapiens 21-30 8933043-7 1996 These data suggest that T helper 1 (Th1) lymphocytes participate in the beryllium disease process; that IFN-gamma levels remain elevated after IL-2 levels return to baseline; and that IL-2 participates directly in beryllium-stimulated T-cell proliferation, but other T-lymphocyte mitogenic cytokines may be involved. Beryllium 214-223 interferon gamma Homo sapiens 104-113 8921440-4 1996 Here we show that at concentrations effective in vivo, linomide is active on human peripheral blood mononuclear cells (PBMC), severely inhibiting the induction by Staphylococcus aureus enterotoxin B of mRNA of three cytokine genes expressed in Th1 cells, those for IFN-gamma, IL-2, and tumor necrosis factor-beta. roquinimex 55-63 interferon gamma Homo sapiens 265-274 8921440-7 1996 Linomide also blocked induction of IL-2 and IFN-gamma mRNA by phytohemagglutinin. roquinimex 0-8 interferon gamma Homo sapiens 44-53 8926087-11 1996 However, addition of tryptophan to IFN-gamma-treated cells significantly reversed the inhibitory effects of IFN-gamma, suggesting that IFN-gamma acts by depleting cellular tryptophan. Tryptophan 21-31 interferon gamma Homo sapiens 35-44 8862284-1 1996 Human immunodeficiency virus (HIV) infection is associated with increased concentrations of neopterin derivatives, released in large quantities by human macrophages on stimulation with interferon-gamma (INF-gamma). Neopterin 92-101 interferon gamma Homo sapiens 185-201 8926087-11 1996 However, addition of tryptophan to IFN-gamma-treated cells significantly reversed the inhibitory effects of IFN-gamma, suggesting that IFN-gamma acts by depleting cellular tryptophan. Tryptophan 21-31 interferon gamma Homo sapiens 108-117 8926087-11 1996 However, addition of tryptophan to IFN-gamma-treated cells significantly reversed the inhibitory effects of IFN-gamma, suggesting that IFN-gamma acts by depleting cellular tryptophan. Tryptophan 21-31 interferon gamma Homo sapiens 108-117 8926087-11 1996 However, addition of tryptophan to IFN-gamma-treated cells significantly reversed the inhibitory effects of IFN-gamma, suggesting that IFN-gamma acts by depleting cellular tryptophan. Tryptophan 172-182 interferon gamma Homo sapiens 35-44 8926087-11 1996 However, addition of tryptophan to IFN-gamma-treated cells significantly reversed the inhibitory effects of IFN-gamma, suggesting that IFN-gamma acts by depleting cellular tryptophan. Tryptophan 172-182 interferon gamma Homo sapiens 108-117 8926087-11 1996 However, addition of tryptophan to IFN-gamma-treated cells significantly reversed the inhibitory effects of IFN-gamma, suggesting that IFN-gamma acts by depleting cellular tryptophan. Tryptophan 172-182 interferon gamma Homo sapiens 108-117 8926118-3 1996 Lipoarabinomannan from M. tuberculosis Erdman and M. leprae mycolylarabinogalactan peptidoglycan were the poorest IFN-gamma inducers. lipoarabinomannan 0-17 interferon gamma Homo sapiens 114-123 8862284-1 1996 Human immunodeficiency virus (HIV) infection is associated with increased concentrations of neopterin derivatives, released in large quantities by human macrophages on stimulation with interferon-gamma (INF-gamma). Neopterin 92-101 interferon gamma Homo sapiens 203-212 8823363-9 1996 As expected, staurosporine and genistein inhibited, whereas okadaic acid augmented, the induction of K17 by IFN gamma. Staurosporine 13-26 interferon gamma Homo sapiens 108-117 8823363-9 1996 As expected, staurosporine and genistein inhibited, whereas okadaic acid augmented, the induction of K17 by IFN gamma. Genistein 31-40 interferon gamma Homo sapiens 108-117 8823363-9 1996 As expected, staurosporine and genistein inhibited, whereas okadaic acid augmented, the induction of K17 by IFN gamma. Okadaic Acid 60-72 interferon gamma Homo sapiens 108-117 8912144-8 1996 However, after preincubation with interferon-gamma, one cell line with low surface Fas expression became anti-Fas sensitive equivalent to the two cell lines expressing surface Fas at high levels. ammonium ferrous sulfate 83-86 interferon gamma Homo sapiens 34-50 8912144-8 1996 However, after preincubation with interferon-gamma, one cell line with low surface Fas expression became anti-Fas sensitive equivalent to the two cell lines expressing surface Fas at high levels. ammonium ferrous sulfate 110-113 interferon gamma Homo sapiens 34-50 8912144-8 1996 However, after preincubation with interferon-gamma, one cell line with low surface Fas expression became anti-Fas sensitive equivalent to the two cell lines expressing surface Fas at high levels. ammonium ferrous sulfate 110-113 interferon gamma Homo sapiens 34-50 8916420-3 1996 The glycan micro-heterogeneity of natural human IFN-gamma was characterized by matrix-assisted laser desorption/ionization mass spectrometry (MALDI/MS) combined with glycosidase digestion. Polysaccharides 4-10 interferon gamma Homo sapiens 48-57 8975455-1 1996 Neopterin, a pteridine derivate, is produced and released by lymphocytes and monocytes/macrophages after stimulation by T-cell derived interferon (IFN) gamma. Neopterin 0-9 interferon gamma Homo sapiens 135-157 8808915-19 1996 Interferon gamma had only minor effects on the response of the cells to doxorubicin or mitomycin C. Doxorubicin 72-83 interferon gamma Homo sapiens 0-16 8808915-19 1996 Interferon gamma had only minor effects on the response of the cells to doxorubicin or mitomycin C. Mitomycin 87-98 interferon gamma Homo sapiens 0-16 8931130-0 1996 Engineered disulfide bonds in recombinant human interferon-gamma: the impact of the N-terminal helix A and the AB-loop on protein stability. Disulfides 11-20 interferon gamma Homo sapiens 48-64 8931130-1 1996 Insertion sites for cysteines with optimal stereochemistry for the formation of unstrained disulfide bridges were identified in recombinant human interferon-gamma (rhu-IFN-gamma) by computer modelling. Cysteine 20-29 interferon gamma Homo sapiens 146-162 8931130-1 1996 Insertion sites for cysteines with optimal stereochemistry for the formation of unstrained disulfide bridges were identified in recombinant human interferon-gamma (rhu-IFN-gamma) by computer modelling. Disulfides 91-100 interferon gamma Homo sapiens 146-162 8975455-1 1996 Neopterin, a pteridine derivate, is produced and released by lymphocytes and monocytes/macrophages after stimulation by T-cell derived interferon (IFN) gamma. Pteridines 13-22 interferon gamma Homo sapiens 135-157 8798625-5 1996 Dexamethasone prevented the coordinate induction of GTP cyclohydrolase I with NOS2 after exposure to interleukin-1beta and interferon-gamma and also the increase in intracellular BH4 content in cytokine-treated CMEC. Dexamethasone 0-13 interferon gamma Homo sapiens 123-139 8964081-2 1996 One of these CD8+ T cell clones, 13G2, secreted IFN-gamma at similar levels with calcium ionophore, A23187, as well as by Con A, but IL-10 production by A23187 was less than by Con A. Calcimycin 100-106 interferon gamma Homo sapiens 48-57 8836130-0 1996 Interferon gamma differentially affects the synthesis of chondroitin/dermatan sulphate and heparan sulphate by human skin fibroblasts. chondroitin/dermatan sulphate 57-86 interferon gamma Homo sapiens 0-16 8836130-0 1996 Interferon gamma differentially affects the synthesis of chondroitin/dermatan sulphate and heparan sulphate by human skin fibroblasts. Heparitin Sulfate 91-107 interferon gamma Homo sapiens 0-16 8836130-3 1996 IFN gamma (250 i.u./ml) induced an increase in incorporation of D-[1-3H]glucosamine into glycosaminoglycans, either secreted into the culture medium or associated with the cell layer. d-[1-3h]glucosamine 64-83 interferon gamma Homo sapiens 0-9 8836130-3 1996 IFN gamma (250 i.u./ml) induced an increase in incorporation of D-[1-3H]glucosamine into glycosaminoglycans, either secreted into the culture medium or associated with the cell layer. Glycosaminoglycans 89-107 interferon gamma Homo sapiens 0-9 8964083-0 1996 Cocaine down-regulates IL-2-induced peripheral blood lymphocyte IL-8 and IFN-gamma production. Cocaine 0-7 interferon gamma Homo sapiens 73-82 8964083-5 1996 Cocaine abrogated the IL-2-induced production of IFN-gamma and IL-8 in a dose-responsive manner. Cocaine 0-7 interferon gamma Homo sapiens 49-58 8964083-6 1996 Cocaine also decreased PBL IFN-gamma and IL-8 mRNA expression as determined by Northern blot and slot blot analysis. Cocaine 0-7 interferon gamma Homo sapiens 27-36 8805617-2 1996 Two predominant pathways are defined that require the concerted action of multivalent membrane Ig cross-linking by the polysaccharide Ag with 1) various B cell-activating moieties contained within the bacterial pathogen and/or 2) cytokines, such as IFN-gamma and granulocyte-macrophage colony-stimulating factor produced by NK cells and macrophages, that become activated in a T cell-independent manner during bacterial infection. Polysaccharides 119-133 interferon gamma Homo sapiens 249-311 8781431-11 1996 Release of IL-4 and IFN-gamma was significantly inhibited by Ver, Tmx, and UIC2; however, release of IL-6 remained unaffected. Tamoxifen 66-69 interferon gamma Homo sapiens 20-29 8809128-6 1996 MTBmix-8 also stimulated the production of interferon-gamma (IFN-gamma) in vitro. mtbmix-8 0-8 interferon gamma Homo sapiens 43-59 8877124-5 1996 Upon stimulation with phytohemagglutinin (PHA) plus phorbol-12-myristate-13-acetate (PMA), RP children produced less IL-2 (P < 0.01) and IFN-gamma (P < 0.02) than SR children and also expressed significantly less IFN-gamma mRNA (P < 0.01) than SR children. Tetradecanoylphorbol Acetate 52-83 interferon gamma Homo sapiens 140-149 8877124-5 1996 Upon stimulation with phytohemagglutinin (PHA) plus phorbol-12-myristate-13-acetate (PMA), RP children produced less IL-2 (P < 0.01) and IFN-gamma (P < 0.02) than SR children and also expressed significantly less IFN-gamma mRNA (P < 0.01) than SR children. Tetradecanoylphorbol Acetate 52-83 interferon gamma Homo sapiens 219-228 8948120-0 1996 The role of reactive oxygen metabolites in the transcriptional regulation of IFN-gamma gene expression by histamine in NK cells following IL-2 stimulation. Oxygen 21-27 interferon gamma Homo sapiens 77-86 8948120-0 1996 The role of reactive oxygen metabolites in the transcriptional regulation of IFN-gamma gene expression by histamine in NK cells following IL-2 stimulation. Histamine 106-115 interferon gamma Homo sapiens 77-86 8948120-4 1996 Both catalase, a scavenger of hydrogen peroxide and histamine, a biogenic amine which inhibits the generation of ROMs by monocytes, strongly abrogated the inhibition of IFN-gamma production. Hydrogen Peroxide 30-47 interferon gamma Homo sapiens 169-178 8948120-4 1996 Both catalase, a scavenger of hydrogen peroxide and histamine, a biogenic amine which inhibits the generation of ROMs by monocytes, strongly abrogated the inhibition of IFN-gamma production. Histamine 52-61 interferon gamma Homo sapiens 169-178 8948120-4 1996 Both catalase, a scavenger of hydrogen peroxide and histamine, a biogenic amine which inhibits the generation of ROMs by monocytes, strongly abrogated the inhibition of IFN-gamma production. Amines 56-61 interferon gamma Homo sapiens 169-178 8948120-4 1996 Both catalase, a scavenger of hydrogen peroxide and histamine, a biogenic amine which inhibits the generation of ROMs by monocytes, strongly abrogated the inhibition of IFN-gamma production. roms 113-117 interferon gamma Homo sapiens 169-178 8948120-5 1996 We thereby conclude that histamine behaves synergistically with IL-2 at a transcriptional level to induce IFN-gamma even in an admixture of NK cells and monocytes. Histamine 25-34 interferon gamma Homo sapiens 106-115 8809128-6 1996 MTBmix-8 also stimulated the production of interferon-gamma (IFN-gamma) in vitro. mtbmix-8 0-8 interferon gamma Homo sapiens 61-70 8809128-8 1996 of the values for IFN-gamma production in the tuberculin-negative population as a cut-off, MTBmix-8 at 6.25 micrograms/ml was able to detect infection with a sensitivity of 100% in untreated patients, 87% in treated patients, and 82% in tuberculin-positive controls. mtbmix-8 91-99 interferon gamma Homo sapiens 18-27 8862260-12 1996 Thalidomide reduces the frequency of IFN-gamma-induced ENL, but also eliminates the IFN-gamma-induced bacillary clearance. Thalidomide 0-11 interferon gamma Homo sapiens 37-46 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrates 33-40 interferon gamma Homo sapiens 307-323 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrites 46-53 interferon gamma Homo sapiens 307-323 8862260-12 1996 Thalidomide reduces the frequency of IFN-gamma-induced ENL, but also eliminates the IFN-gamma-induced bacillary clearance. Thalidomide 0-11 interferon gamma Homo sapiens 84-93 8784069-4 1996 The cytokine combination of interleukin-1 beta (50 U/mL), tumor necrosis factor-alpha (10(3) U/mL), and interferon-gamma (10(3) U/mL) induced significant increases in MDA and nitrite and significant decreases in insulin and DNA in islets after 60-h incubation. Nitrites 175-182 interferon gamma Homo sapiens 104-120 8886999-9 1996 In PBMC stimulated with phytohemagglutinin and phorbol ester, there was a decrease (72-87%) in interferon-gamma (IFN gamma) production 6 hr after IL-10 with a return to pre-IL-10 levels after 24 hr. Phorbol Esters 47-60 interferon gamma Homo sapiens 95-111 8787685-7 1996 Incubation of cells with antisense oligonucleotides targeting STATlalpha mRNA resulted in inhibition of DNA synthesis induced by the combination of IFN-gamma and PDGF or EGF. Oligonucleotides 35-51 interferon gamma Homo sapiens 148-157 9064335-6 1996 Blood mononuclear cells from RA patients had increased NOS activity and increased NOS2 antigen content as compared to those from normal subjects, and responded to interferon-gamma with increased NOS expression and nitrite/nitrate production in vitro. Nitrites 214-221 interferon gamma Homo sapiens 163-179 9064335-6 1996 Blood mononuclear cells from RA patients had increased NOS activity and increased NOS2 antigen content as compared to those from normal subjects, and responded to interferon-gamma with increased NOS expression and nitrite/nitrate production in vitro. Nitrates 222-229 interferon gamma Homo sapiens 163-179 8751967-0 1996 Inhibitors of sphingolipid synthesis modulate interferon (IFN)-gamma-induced intercellular adhesion molecule (ICAM)-1 and human leukocyte antigen (HLA)-DR expression on cultured normal human keratinocytes: possible involvement of ceramide in biologic action of IFN-gamma. Sphingolipids 14-26 interferon gamma Homo sapiens 261-270 8751967-2 1996 Pretreatment of keratinocytes with L-cycloserine or fumonisin B1, but not 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), significantly suppressed both ICAM-1 and HLA-DR expression induced by IFN-gamma. L-Cycloserine 35-48 interferon gamma Homo sapiens 201-210 8751967-2 1996 Pretreatment of keratinocytes with L-cycloserine or fumonisin B1, but not 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), significantly suppressed both ICAM-1 and HLA-DR expression induced by IFN-gamma. fumonisin B1 52-64 interferon gamma Homo sapiens 201-210 8751967-3 1996 Because the synthesis of all kinds of sphingolipids is blocked by L-cycloserine and all except that of sphinganine by fumonisin B1, whereas PDMP inhibits the synthesis of glucosylceramide and glycosphingolipids, the result suggests the participation of ceramide and/or sphingosine in IFN-gamma-induced ICAM-1 and HLA-DR expression. Sphingolipids 38-51 interferon gamma Homo sapiens 284-293 8751967-3 1996 Because the synthesis of all kinds of sphingolipids is blocked by L-cycloserine and all except that of sphinganine by fumonisin B1, whereas PDMP inhibits the synthesis of glucosylceramide and glycosphingolipids, the result suggests the participation of ceramide and/or sphingosine in IFN-gamma-induced ICAM-1 and HLA-DR expression. RV 538 140-144 interferon gamma Homo sapiens 284-293 8751967-7 1996 In addition, reverse transcriptase polymerase chain reaction showed that L-cycloserine reduced the mRNA for ICAM-1, HLA-DR alpha, and HLA-DR beta induced by IFN-gamma, and C2-ceramide and sphingosine antagonized the effect of L-cycloserine. L-Cycloserine 73-86 interferon gamma Homo sapiens 157-166 8751967-7 1996 In addition, reverse transcriptase polymerase chain reaction showed that L-cycloserine reduced the mRNA for ICAM-1, HLA-DR alpha, and HLA-DR beta induced by IFN-gamma, and C2-ceramide and sphingosine antagonized the effect of L-cycloserine. L-Cycloserine 226-239 interferon gamma Homo sapiens 157-166 8751967-8 1996 Furthermore, the degradation rate of fluorescent sphingomyelin into ceramide in keratinocytes was increased by IFN-gamma, suggesting that IFN-gamma activates sphingomyelin hydrolysis in keratinocytes. Sphingomyelins 49-62 interferon gamma Homo sapiens 111-120 8751967-8 1996 Furthermore, the degradation rate of fluorescent sphingomyelin into ceramide in keratinocytes was increased by IFN-gamma, suggesting that IFN-gamma activates sphingomyelin hydrolysis in keratinocytes. Sphingomyelins 49-62 interferon gamma Homo sapiens 138-147 8751967-8 1996 Furthermore, the degradation rate of fluorescent sphingomyelin into ceramide in keratinocytes was increased by IFN-gamma, suggesting that IFN-gamma activates sphingomyelin hydrolysis in keratinocytes. Ceramides 68-76 interferon gamma Homo sapiens 111-120 8751967-8 1996 Furthermore, the degradation rate of fluorescent sphingomyelin into ceramide in keratinocytes was increased by IFN-gamma, suggesting that IFN-gamma activates sphingomyelin hydrolysis in keratinocytes. Ceramides 68-76 interferon gamma Homo sapiens 138-147 8751967-8 1996 Furthermore, the degradation rate of fluorescent sphingomyelin into ceramide in keratinocytes was increased by IFN-gamma, suggesting that IFN-gamma activates sphingomyelin hydrolysis in keratinocytes. Sphingomyelins 158-171 interferon gamma Homo sapiens 111-120 8751967-8 1996 Furthermore, the degradation rate of fluorescent sphingomyelin into ceramide in keratinocytes was increased by IFN-gamma, suggesting that IFN-gamma activates sphingomyelin hydrolysis in keratinocytes. Sphingomyelins 158-171 interferon gamma Homo sapiens 138-147 8751967-9 1996 These observations suggest the possible role of ceramide in IFN-gamma-induced ICAM-1 and HLA-DR expression on keratinocytes. Ceramides 48-56 interferon gamma Homo sapiens 60-69 8757309-9 1996 IFN-gamma production could be completely restored by rIL-12, whereas the addition of IL-1 beta, TNF-alpha, or indomethacin had no such effect, nor did the addition of mAb to CD28, added to compensate for the reduced B7 expression of UVB-irradiated monocytes. ril-12 53-59 interferon gamma Homo sapiens 0-9 8757337-3 1996 An inducible form of cyclo-oxygenase (COX 2) was demonstrated in astrocytes and microglia after IL-1 beta plus IFN-gamma stimulation; since 1) large amounts of PGF2 alpha were released; 2) PGF2 alpha secretion required protein synthesis and was blocked by indomethacin; and 3) the response was delayed and persistent. Dinoprost 160-164 interferon gamma Homo sapiens 111-120 8757337-3 1996 An inducible form of cyclo-oxygenase (COX 2) was demonstrated in astrocytes and microglia after IL-1 beta plus IFN-gamma stimulation; since 1) large amounts of PGF2 alpha were released; 2) PGF2 alpha secretion required protein synthesis and was blocked by indomethacin; and 3) the response was delayed and persistent. Dinoprost 189-193 interferon gamma Homo sapiens 111-120 8757337-3 1996 An inducible form of cyclo-oxygenase (COX 2) was demonstrated in astrocytes and microglia after IL-1 beta plus IFN-gamma stimulation; since 1) large amounts of PGF2 alpha were released; 2) PGF2 alpha secretion required protein synthesis and was blocked by indomethacin; and 3) the response was delayed and persistent. Indomethacin 256-268 interferon gamma Homo sapiens 111-120 8757337-6 1996 Conversely, microglial cells were induced by IL-1 beta and IFN-gamma to generate superoxide anions (O2.-) through an NADPH oxidase-dependent pathway. Superoxides 81-98 interferon gamma Homo sapiens 59-68 8757337-6 1996 Conversely, microglial cells were induced by IL-1 beta and IFN-gamma to generate superoxide anions (O2.-) through an NADPH oxidase-dependent pathway. Superoxides 100-102 interferon gamma Homo sapiens 59-68 8757342-6 1996 However, the p28-40 analogues with alanine residues at positions 34 and 36 altered the IFN-gamma:IL-4 ratio by selectively enhancing IFN-gamma secretion. Alanine 35-42 interferon gamma Homo sapiens 87-96 8757342-6 1996 However, the p28-40 analogues with alanine residues at positions 34 and 36 altered the IFN-gamma:IL-4 ratio by selectively enhancing IFN-gamma secretion. Alanine 35-42 interferon gamma Homo sapiens 133-142 8830800-4 1996 In addition, huGBPs expressed from the endogenous genes in IFN-gamma-treated human fibroblasts or monocytic cells were also found to be isoprenoid modified. Terpenes 136-146 interferon gamma Homo sapiens 59-68 8830800-5 1996 IFN-gamma-induced huGBPs in HL-60 cells were not labeled by the specific C20 isoprenoid, [3H]geranylgeraniol, but did show decreased isoprenoid incorporation in cells treated with the farnesyl transferase inhibitor BZA-5B, indicating that huGBPs in HL-60 cells are probably modified by a C15 farnesyl rather than the more common C20 lipid. c20 isoprenoid 73-87 interferon gamma Homo sapiens 0-9 8830800-5 1996 IFN-gamma-induced huGBPs in HL-60 cells were not labeled by the specific C20 isoprenoid, [3H]geranylgeraniol, but did show decreased isoprenoid incorporation in cells treated with the farnesyl transferase inhibitor BZA-5B, indicating that huGBPs in HL-60 cells are probably modified by a C15 farnesyl rather than the more common C20 lipid. Tritium 90-92 interferon gamma Homo sapiens 0-9 8830800-5 1996 IFN-gamma-induced huGBPs in HL-60 cells were not labeled by the specific C20 isoprenoid, [3H]geranylgeraniol, but did show decreased isoprenoid incorporation in cells treated with the farnesyl transferase inhibitor BZA-5B, indicating that huGBPs in HL-60 cells are probably modified by a C15 farnesyl rather than the more common C20 lipid. Terpenes 77-87 interferon gamma Homo sapiens 0-9 8830800-5 1996 IFN-gamma-induced huGBPs in HL-60 cells were not labeled by the specific C20 isoprenoid, [3H]geranylgeraniol, but did show decreased isoprenoid incorporation in cells treated with the farnesyl transferase inhibitor BZA-5B, indicating that huGBPs in HL-60 cells are probably modified by a C15 farnesyl rather than the more common C20 lipid. BZA 5B 215-221 interferon gamma Homo sapiens 0-9 8830800-5 1996 IFN-gamma-induced huGBPs in HL-60 cells were not labeled by the specific C20 isoprenoid, [3H]geranylgeraniol, but did show decreased isoprenoid incorporation in cells treated with the farnesyl transferase inhibitor BZA-5B, indicating that huGBPs in HL-60 cells are probably modified by a C15 farnesyl rather than the more common C20 lipid. cgp 53820 73-76 interferon gamma Homo sapiens 0-9 8887061-0 1996 Treatment of ME180 cells with interferon-gamma causes apoptosis as a result of tryptophan starvation. Tryptophan 79-89 interferon gamma Homo sapiens 30-46 8886999-9 1996 In PBMC stimulated with phytohemagglutinin and phorbol ester, there was a decrease (72-87%) in interferon-gamma (IFN gamma) production 6 hr after IL-10 with a return to pre-IL-10 levels after 24 hr. Phorbol Esters 47-60 interferon gamma Homo sapiens 113-122 8880934-8 1996 SDS PAGE analysis of the crystals demonstrated that both interferon gamma and the receptor were present. Sodium Dodecyl Sulfate 0-3 interferon gamma Homo sapiens 57-73 8931110-1 1996 RAW 264.7 macrophages respond to lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) by producing large amounts of nitric oxide (NO) and prostaglandin E2 (PGE2), with maximal production 18-24 h after treatment. Nitric Oxide 121-133 interferon gamma Homo sapiens 62-78 8759739-3 1996 We have previously demonstrated that IFN-gamma-induced class II expression in glial cells involves activation of both tyrosine kinase and protein kinase C. IFN-gamma induces tyrosine phosphorylation of the tyrosine kinases Jak1 and Jak2 and of Stat1 alpha. Tyrosine 118-126 interferon gamma Homo sapiens 37-46 8931110-1 1996 RAW 264.7 macrophages respond to lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) by producing large amounts of nitric oxide (NO) and prostaglandin E2 (PGE2), with maximal production 18-24 h after treatment. Nitric Oxide 121-133 interferon gamma Homo sapiens 80-89 8931110-1 1996 RAW 264.7 macrophages respond to lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) by producing large amounts of nitric oxide (NO) and prostaglandin E2 (PGE2), with maximal production 18-24 h after treatment. Dinoprostone 143-159 interferon gamma Homo sapiens 62-78 8931110-1 1996 RAW 264.7 macrophages respond to lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) by producing large amounts of nitric oxide (NO) and prostaglandin E2 (PGE2), with maximal production 18-24 h after treatment. Dinoprostone 143-159 interferon gamma Homo sapiens 80-89 8931110-1 1996 RAW 264.7 macrophages respond to lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) by producing large amounts of nitric oxide (NO) and prostaglandin E2 (PGE2), with maximal production 18-24 h after treatment. Dinoprostone 161-165 interferon gamma Homo sapiens 62-78 8931110-1 1996 RAW 264.7 macrophages respond to lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) by producing large amounts of nitric oxide (NO) and prostaglandin E2 (PGE2), with maximal production 18-24 h after treatment. Dinoprostone 161-165 interferon gamma Homo sapiens 80-89 8759739-3 1996 We have previously demonstrated that IFN-gamma-induced class II expression in glial cells involves activation of both tyrosine kinase and protein kinase C. IFN-gamma induces tyrosine phosphorylation of the tyrosine kinases Jak1 and Jak2 and of Stat1 alpha. Tyrosine 118-126 interferon gamma Homo sapiens 156-165 8759739-6 1996 Antisense oligonucleotides complementary to Stat1 alpha mRNA were introduced in CH235-MG astroglioma cells by transient transfection; such treatment inhibited both constitutive and IFN-gamma-enhanced expression of Stat1 alpha. Oligonucleotides 10-26 interferon gamma Homo sapiens 181-190 8759739-7 1996 IFN-gamma-induced class II MHC expression was also inhibited in cells exposed to Stat1 alpha antisense oligonucleotides. Oligonucleotides 103-119 interferon gamma Homo sapiens 0-9 8759739-10 1996 IFN-gamma induction of CIITA mRNA was also inhibited in cells treated with antisense oligonucleotides against Stat1 alpha. Oligonucleotides 85-101 interferon gamma Homo sapiens 0-9 8759613-6 1996 Interferon-gamma inhibited IL-4- and IL-13-dependent spermidine uptake to a much greater extent than basal or insulin-induced transport of the polyamine. Spermidine 53-63 interferon gamma Homo sapiens 0-16 8706348-6 1996 Hydrogen peroxide, at micromolar concentrations, reconstituted the inhibition of IFN-gamma production when added to enriched NK cells. Hydrogen Peroxide 0-17 interferon gamma Homo sapiens 81-90 8706348-7 1996 Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes. Histamine 0-9 interferon gamma Homo sapiens 131-140 8706348-7 1996 Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes. Histamine 0-9 interferon gamma Homo sapiens 234-243 8706348-7 1996 Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes. Amines 4-9 interferon gamma Homo sapiens 131-140 8706348-7 1996 Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes. Amines 4-9 interferon gamma Homo sapiens 234-243 8706348-7 1996 Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes. Oxygen 70-76 interferon gamma Homo sapiens 131-140 8706348-7 1996 Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes. Histamine 184-193 interferon gamma Homo sapiens 131-140 8706348-7 1996 Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes. Histamine 184-193 interferon gamma Homo sapiens 234-243 8706348-9 1996 We conclude that: (i) the induction of IFN-gamma mRNA in NK cells is effectively down-regulated by products of the oxidative metabolism of monocytes; and (ii) histamine effectively enhances IFN-gamma production by preventing monocyte-induced oxidative damage to NK cells. Histamine 159-168 interferon gamma Homo sapiens 39-48 8706348-9 1996 We conclude that: (i) the induction of IFN-gamma mRNA in NK cells is effectively down-regulated by products of the oxidative metabolism of monocytes; and (ii) histamine effectively enhances IFN-gamma production by preventing monocyte-induced oxidative damage to NK cells. Histamine 159-168 interferon gamma Homo sapiens 190-199 8894440-2 1996 Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma). Citrulline 0-10 interferon gamma Homo sapiens 248-275 8894440-2 1996 Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma). Arginine 27-35 interferon gamma Homo sapiens 248-275 8754734-5 1996 In contrast, treatment of thyrocytes with either interleukin-1 beta (IL-1 beta) or interferon- gamma (IFN gamma) markedly increased Fas antigen expression on thyrocytes, and these effects were inhibited in the presence of TSH. Thyrotropin 222-225 interferon gamma Homo sapiens 83-100 8754734-5 1996 In contrast, treatment of thyrocytes with either interleukin-1 beta (IL-1 beta) or interferon- gamma (IFN gamma) markedly increased Fas antigen expression on thyrocytes, and these effects were inhibited in the presence of TSH. Thyrotropin 222-225 interferon gamma Homo sapiens 102-111 8754734-7 1996 When thyrocytes stimulated with either IL-1 beta or IFN gamma were treated with anti-Fas IgM mAb, the cells were committed to apoptosis, whereas this apoptotic process was significantly inhibited by the addition of TSH. Thyrotropin 215-218 interferon gamma Homo sapiens 52-61 8871051-4 1996 PGE2 favours Th2-like cytokine secretion profiles by inhibiting the production of the Th1-associated cytokines, IL-2 and IFN-gamma, and in the presence of sufficient levels of IL-2, upregulating the production of the Th2-associated cytokines, IL-4 and IL-5, IL-12, on the other hand, induces and enhances IFN-gamma secretion in activated CD4+ T-cells, thereby promoting the generation of Th1 cells. Dinoprostone 0-4 interferon gamma Homo sapiens 121-130 8871051-4 1996 PGE2 favours Th2-like cytokine secretion profiles by inhibiting the production of the Th1-associated cytokines, IL-2 and IFN-gamma, and in the presence of sufficient levels of IL-2, upregulating the production of the Th2-associated cytokines, IL-4 and IL-5, IL-12, on the other hand, induces and enhances IFN-gamma secretion in activated CD4+ T-cells, thereby promoting the generation of Th1 cells. Dinoprostone 0-4 interferon gamma Homo sapiens 305-314 8871052-6 1996 In three out of nine clones tested, the stimulation with anti-CD2/CD28/phorbol myristate acetate (PMA) induced a shift of the IFN-gamma/IL-4 ratio towards a Th2-type cytokine profile. Tetradecanoylphorbol Acetate 71-96 interferon gamma Homo sapiens 126-135 8871052-6 1996 In three out of nine clones tested, the stimulation with anti-CD2/CD28/phorbol myristate acetate (PMA) induced a shift of the IFN-gamma/IL-4 ratio towards a Th2-type cytokine profile. Tetradecanoylphorbol Acetate 98-101 interferon gamma Homo sapiens 126-135 8877405-2 1996 Neopterin production was not induced when the human myelomono-cytoma cell line THP-1 was stimulated with these toxins, and there was only a slight co-stimulatory effect of streptococcal erythrogenic toxin A together with interferon-gamma stimulation. Neopterin 0-9 interferon gamma Homo sapiens 221-237 8872491-1 1996 We have previously shown that interferon-gamma (IFN-gamma) increases intracellular levels of the lysosomal proteinase, CB, in THP-1 cell primed with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 149-180 interferon gamma Homo sapiens 30-46 8872491-1 1996 We have previously shown that interferon-gamma (IFN-gamma) increases intracellular levels of the lysosomal proteinase, CB, in THP-1 cell primed with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 149-180 interferon gamma Homo sapiens 48-57 8872491-1 1996 We have previously shown that interferon-gamma (IFN-gamma) increases intracellular levels of the lysosomal proteinase, CB, in THP-1 cell primed with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 182-185 interferon gamma Homo sapiens 30-46 8877405-4 1996 This neopterin formation could be blocked by anti-human interferon-gamma. Neopterin 5-14 interferon gamma Homo sapiens 56-72 8872491-1 1996 We have previously shown that interferon-gamma (IFN-gamma) increases intracellular levels of the lysosomal proteinase, CB, in THP-1 cell primed with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 182-185 interferon gamma Homo sapiens 48-57 8877405-6 1996 However, the data obtained in peripheral blood mononuclear cell culture imply that these toxins are able to stimulate neopterin production in humans via the induction of huge amounts of interferon-gamma. Neopterin 118-127 interferon gamma Homo sapiens 186-202 8872491-4 1996 With the addition of protein kinase C (PKC) inhibitors bisindolylmaleimide, staurosporine, H-7, or phloretin a reversal of the effect of IFN-gamma was noted whereas the addition of the cyclic nucleotide-dependent protein kinase inhibitors HA 1004, H-8, H-89, or cAMP-Dependent Protein Kinase (PKA) Inhibitor did not block the effect. bisindolylmaleimide 55-74 interferon gamma Homo sapiens 137-146 8872491-4 1996 With the addition of protein kinase C (PKC) inhibitors bisindolylmaleimide, staurosporine, H-7, or phloretin a reversal of the effect of IFN-gamma was noted whereas the addition of the cyclic nucleotide-dependent protein kinase inhibitors HA 1004, H-8, H-89, or cAMP-Dependent Protein Kinase (PKA) Inhibitor did not block the effect. Staurosporine 76-89 interferon gamma Homo sapiens 137-146 21541518-1 1996 The immunomodulator ammonium trichloro (dioxyethylene-O-O")tellurate (AS101) has previously been found to induce secretion of various cytokines in mouse and human, which include interleukin-l, interleukin-2, colony-stimulating factor, interferon-gamma, tumor necrosis factor, etc. ammonium trichloro (dioxyethylene-o-o")tellurate 20-68 interferon gamma Homo sapiens 235-251 8872491-4 1996 With the addition of protein kinase C (PKC) inhibitors bisindolylmaleimide, staurosporine, H-7, or phloretin a reversal of the effect of IFN-gamma was noted whereas the addition of the cyclic nucleotide-dependent protein kinase inhibitors HA 1004, H-8, H-89, or cAMP-Dependent Protein Kinase (PKA) Inhibitor did not block the effect. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 91-94 interferon gamma Homo sapiens 137-146 8872491-4 1996 With the addition of protein kinase C (PKC) inhibitors bisindolylmaleimide, staurosporine, H-7, or phloretin a reversal of the effect of IFN-gamma was noted whereas the addition of the cyclic nucleotide-dependent protein kinase inhibitors HA 1004, H-8, H-89, or cAMP-Dependent Protein Kinase (PKA) Inhibitor did not block the effect. Phloretin 99-108 interferon gamma Homo sapiens 137-146 21541518-1 1996 The immunomodulator ammonium trichloro (dioxyethylene-O-O")tellurate (AS101) has previously been found to induce secretion of various cytokines in mouse and human, which include interleukin-l, interleukin-2, colony-stimulating factor, interferon-gamma, tumor necrosis factor, etc. ammonium trichloro(dioxoethylene-O,O'-)tellurate 70-75 interferon gamma Homo sapiens 235-251 8760410-5 1996 Interferon gamma (IFN-gamma) stimulation however, resulted in reduced levels of nitrite accumulation as a direct consequence of Tat expression. Nitrites 80-87 interferon gamma Homo sapiens 0-27 8699070-3 1996 OvAg-stimulated IL-4 and interferon (IFN)-gamma levels were essentially undetectable in either group. ovag 0-4 interferon gamma Homo sapiens 25-47 8760410-6 1996 Conditioned media from Tat-expressing cells reduced the level of nitrite accumulation in parental cells following IFN-gamma stimulation but not stimulation with LPS. Nitrites 65-72 interferon gamma Homo sapiens 114-123 8760301-3 1996 We report that 8-bromo-cAMP (8Br-cAMP) and lipopolysaccharide (LPS) potently reduced CSF-1-stimulated cyclin D1 protein, and cyclin-dependent kinase (cdk) 4 mRNA and protein levels, while the inhibitory effects of the Na+/ H+ antiport inhibitor 5-(N",N"-dimethyl) amiloride (DMA) and interferon gamma (IFN gamma ) were only weak. 8-Bromo Cyclic Adenosine Monophosphate 15-27 interferon gamma Homo sapiens 284-300 8760796-7 1996 Fas-mediated neutrophil apoptosis was suppressed by incubation with G-CSF, GM-CSF, IFN-gamma, TNF-alpha, or dexamethasone, as well as the selective tyrosine kinase inhibitors, herbimycin A and genistein. ammonium ferrous sulfate 0-3 interferon gamma Homo sapiens 83-92 8760301-3 1996 We report that 8-bromo-cAMP (8Br-cAMP) and lipopolysaccharide (LPS) potently reduced CSF-1-stimulated cyclin D1 protein, and cyclin-dependent kinase (cdk) 4 mRNA and protein levels, while the inhibitory effects of the Na+/ H+ antiport inhibitor 5-(N",N"-dimethyl) amiloride (DMA) and interferon gamma (IFN gamma ) were only weak. 8-Bromo Cyclic Adenosine Monophosphate 15-27 interferon gamma Homo sapiens 302-311 8760301-3 1996 We report that 8-bromo-cAMP (8Br-cAMP) and lipopolysaccharide (LPS) potently reduced CSF-1-stimulated cyclin D1 protein, and cyclin-dependent kinase (cdk) 4 mRNA and protein levels, while the inhibitory effects of the Na+/ H+ antiport inhibitor 5-(N",N"-dimethyl) amiloride (DMA) and interferon gamma (IFN gamma ) were only weak. 8-Bromo Cyclic Adenosine Monophosphate 29-37 interferon gamma Homo sapiens 284-300 8760301-3 1996 We report that 8-bromo-cAMP (8Br-cAMP) and lipopolysaccharide (LPS) potently reduced CSF-1-stimulated cyclin D1 protein, and cyclin-dependent kinase (cdk) 4 mRNA and protein levels, while the inhibitory effects of the Na+/ H+ antiport inhibitor 5-(N",N"-dimethyl) amiloride (DMA) and interferon gamma (IFN gamma ) were only weak. 8-Bromo Cyclic Adenosine Monophosphate 29-37 interferon gamma Homo sapiens 302-311 8690531-2 1996 We previously reported that the ability of a neuroblastoma (NB) cell line, LAN-5, to accumulate MIBG was powerfully stimulated by interferon-gamma (IFN-gamma), a well-known NB differentiation-promoting agent. 3-Iodobenzylguanidine 96-100 interferon gamma Homo sapiens 148-157 8752940-0 1996 IFN-gamma-induced MHC class II gene expression is suppressed in endothelial cells by dextran sulfate. Dextran Sulfate 85-100 interferon gamma Homo sapiens 0-9 8752940-2 1996 In this study, dextran sulfate, a synthetic heparin analogue, was shown to selectively inhibit IFN-gamma-induced surface expression of HLA-DR molecules by human umbilical cord vascular endothelial cells, but not other cytokine-induced molecules such as ELAM-1 or ICAM-1. Dextran Sulfate 15-30 interferon gamma Homo sapiens 95-104 8752940-2 1996 In this study, dextran sulfate, a synthetic heparin analogue, was shown to selectively inhibit IFN-gamma-induced surface expression of HLA-DR molecules by human umbilical cord vascular endothelial cells, but not other cytokine-induced molecules such as ELAM-1 or ICAM-1. Heparin 44-51 interferon gamma Homo sapiens 95-104 8752940-7 1996 Dextran sulfate also prevented transcription of the gene encoding CIITA, a transactivator protein required for IFN-gamma-inducible expression of class II genes. Dextran Sulfate 0-15 interferon gamma Homo sapiens 111-120 8752940-8 1996 Thus, dextran sulfate apparently inhibited this step or an earlier one in the intracellular signaling pathway for IFN-gamma in human endothelial cells, subsequent to IFN-gamma binding to its cell surface receptor. Dextran Sulfate 6-21 interferon gamma Homo sapiens 114-123 8752940-8 1996 Thus, dextran sulfate apparently inhibited this step or an earlier one in the intracellular signaling pathway for IFN-gamma in human endothelial cells, subsequent to IFN-gamma binding to its cell surface receptor. Dextran Sulfate 6-21 interferon gamma Homo sapiens 166-175 8663206-0 1996 Heparin decreases the blood clearance of interferon-gamma and increases its activity by limiting the processing of its carboxyl-terminal sequence. Heparin 0-7 interferon gamma Homo sapiens 41-57 8663206-1 1996 Interferon-gamma (IFN-gamma) binds with high affinity to heparan sulfate and heparin molecules through its carboxyl-terminal domain. Heparitin Sulfate 57-72 interferon gamma Homo sapiens 0-16 8663206-1 1996 Interferon-gamma (IFN-gamma) binds with high affinity to heparan sulfate and heparin molecules through its carboxyl-terminal domain. Heparitin Sulfate 57-72 interferon gamma Homo sapiens 18-27 8663206-1 1996 Interferon-gamma (IFN-gamma) binds with high affinity to heparan sulfate and heparin molecules through its carboxyl-terminal domain. Heparin 77-84 interferon gamma Homo sapiens 0-16 8663206-1 1996 Interferon-gamma (IFN-gamma) binds with high affinity to heparan sulfate and heparin molecules through its carboxyl-terminal domain. Heparin 77-84 interferon gamma Homo sapiens 18-27 8663206-2 1996 In vivo, IFN-gamma is eliminated from the bloodstream with a half-life (t1/2) of 1.1 min, due to binding to heparan sulfate. Heparitin Sulfate 108-123 interferon gamma Homo sapiens 9-18 8663206-4 1996 When bound to heparin, the plasma clearance of IFN-gamma is decreased greatly (t1/2 = 99 min), and the area under the curve obtained with IFN-gamma alone represented only 15% of that obtained with injected IFN-gamma bound to heparin. Heparin 14-21 interferon gamma Homo sapiens 47-56 8663206-4 1996 When bound to heparin, the plasma clearance of IFN-gamma is decreased greatly (t1/2 = 99 min), and the area under the curve obtained with IFN-gamma alone represented only 15% of that obtained with injected IFN-gamma bound to heparin. Heparin 14-21 interferon gamma Homo sapiens 138-147 8663206-4 1996 When bound to heparin, the plasma clearance of IFN-gamma is decreased greatly (t1/2 = 99 min), and the area under the curve obtained with IFN-gamma alone represented only 15% of that obtained with injected IFN-gamma bound to heparin. Heparin 14-21 interferon gamma Homo sapiens 138-147 8663206-4 1996 When bound to heparin, the plasma clearance of IFN-gamma is decreased greatly (t1/2 = 99 min), and the area under the curve obtained with IFN-gamma alone represented only 15% of that obtained with injected IFN-gamma bound to heparin. Heparin 225-232 interferon gamma Homo sapiens 47-56 8663206-5 1996 Furthermore, the binding of heparin to IFN-gamma limits the extent of its carboxyl-terminal domain degradation to less than 10 amino acids. Heparin 28-35 interferon gamma Homo sapiens 39-48 8663206-7 1996 These data demonstrate that the blood clearance of the cytokine is a non-receptor-mediated process and that in vivo the local concentration of heparan sulfate/heparin-like molecules regulates IFN-gamma activity by a unique mechanism involving a controlled processing of its carboxyl-terminal sequence. Heparitin Sulfate 143-158 interferon gamma Homo sapiens 192-201 8663206-7 1996 These data demonstrate that the blood clearance of the cytokine is a non-receptor-mediated process and that in vivo the local concentration of heparan sulfate/heparin-like molecules regulates IFN-gamma activity by a unique mechanism involving a controlled processing of its carboxyl-terminal sequence. Heparin 159-166 interferon gamma Homo sapiens 192-201 8690531-2 1996 We previously reported that the ability of a neuroblastoma (NB) cell line, LAN-5, to accumulate MIBG was powerfully stimulated by interferon-gamma (IFN-gamma), a well-known NB differentiation-promoting agent. 3-Iodobenzylguanidine 96-100 interferon gamma Homo sapiens 130-146 8690531-4 1996 Our results show that association of IFN-gamma and tumor necrosis factor-alpha boosts MIBG uptake in the early times of incubation in LAN-5 and GI-LI-N cells, while both SK-N-SH and SK-N-BE(2)c cells are strongly stimulated by co-treatment with IFN-gamma and all-trans retinoic acid. 3-Iodobenzylguanidine 86-90 interferon gamma Homo sapiens 37-78 8690531-4 1996 Our results show that association of IFN-gamma and tumor necrosis factor-alpha boosts MIBG uptake in the early times of incubation in LAN-5 and GI-LI-N cells, while both SK-N-SH and SK-N-BE(2)c cells are strongly stimulated by co-treatment with IFN-gamma and all-trans retinoic acid. 3-Iodobenzylguanidine 86-90 interferon gamma Homo sapiens 37-46 8690531-4 1996 Our results show that association of IFN-gamma and tumor necrosis factor-alpha boosts MIBG uptake in the early times of incubation in LAN-5 and GI-LI-N cells, while both SK-N-SH and SK-N-BE(2)c cells are strongly stimulated by co-treatment with IFN-gamma and all-trans retinoic acid. Nitrogen 149-151 interferon gamma Homo sapiens 37-78 8690531-4 1996 Our results show that association of IFN-gamma and tumor necrosis factor-alpha boosts MIBG uptake in the early times of incubation in LAN-5 and GI-LI-N cells, while both SK-N-SH and SK-N-BE(2)c cells are strongly stimulated by co-treatment with IFN-gamma and all-trans retinoic acid. Nitrogen 149-151 interferon gamma Homo sapiens 37-46 8690531-5 1996 Moreover, although only LAN-5 and GI-LI-N cells are sensitive to IFN-gamma alone, the combination of IFN-gamma and IFN-alpha causes a synergistic increase in MIBG uptake in all the NB cell lines tested. 3-Iodobenzylguanidine 158-162 interferon gamma Homo sapiens 101-110 8765975-4 1996 Stimulation caused a two- to threefold higher number of IFN-gamma+ cells in TL (GD, 48 +/- 12%; TA, 48 +/- 11%; NTG, 50 +/- 15%) as compared to PBL (GD, 15 +/- 7%; TA, 16 +/- 8%, NTG, 18 +/- 10%) of the same patients. Tantalum 96-98 interferon gamma Homo sapiens 56-65 8694804-3 1996 Incubation of the macrophage cell line IC 21 with interferon-gamma gave rise to both interleukin-12 p40 mRNA and nitric oxide production. Nitric Oxide 113-125 interferon gamma Homo sapiens 50-66 8871734-3 1996 The improvement of symptoms of allergen rhinitis induced by corticosteroid therapy or immunotherapy were associated with differences in cytokine expression, whereas, steroids decreased IL-4 expression and immunotherapy increased expression of IL-2 and IFN-gamma. Steroids 166-174 interferon gamma Homo sapiens 252-261 8891437-1 1996 In addition to its cellular receptor, interferon-gamma (IFN-gamma) displays a high affinity for heparan sulfate. Heparitin Sulfate 96-111 interferon gamma Homo sapiens 38-54 8891437-1 1996 In addition to its cellular receptor, interferon-gamma (IFN-gamma) displays a high affinity for heparan sulfate. Heparitin Sulfate 96-111 interferon gamma Homo sapiens 56-65 8832287-2 1996 Cytokine capture assays revealed that suramin inhibited the production of IFN-gamma, whilst IL-4 is increased in splenocytes. Suramin 38-45 interferon gamma Homo sapiens 74-83 8891437-3 1996 For this purpose, rats were injected with [125I]-labelled human IFN-gamma, which does not bind to murine IFN-gamma receptors, but binds to murine heparan sulfate. Heparitin Sulfate 146-161 interferon gamma Homo sapiens 64-73 8891437-5 1996 Furthermore, [125I]-IFN-gamma was detected by autoradiographic analysis only in restricted areas within tissues, which correlates with the known locations of heparan sulfate. Heparitin Sulfate 158-173 interferon gamma Homo sapiens 20-29 8891437-7 1996 Heparin bound to [125I]-IFN-gamma was also used to block the heparan sulfate binding site of the cytokine. Heparin 0-7 interferon gamma Homo sapiens 24-33 8891437-7 1996 Heparin bound to [125I]-IFN-gamma was also used to block the heparan sulfate binding site of the cytokine. Heparitin Sulfate 61-76 interferon gamma Homo sapiens 24-33 8832287-5 1996 Suramin also inhibited IFN-gamma production by SP39A1, whilst IL-4 production by SP41D5 was enhanced. Suramin 0-7 interferon gamma Homo sapiens 23-32 8891437-8 1996 In this case, blood clearance and tissue accumulation in the liver and spleen were strongly inhibited, while in the kidney the distribution, but not the accumulation, of [125I]-IFN-gamma was affected by the presence of heparin. Heparin 219-226 interferon gamma Homo sapiens 177-186 8884543-0 1996 Relationship between serum 3,5,3"-triiodothyronine and serum interleukin-8, interleukin-10 or interferon gamma in patients with nonthyroidal illness. 3,5,3"-triiodothyronine 27-50 interferon gamma Homo sapiens 94-110 8891437-10 1996 Taken together, these data demonstrate that heparan sulfate molecules are involved in blood clearance and in the subsequent tissue targeting, accumulation, and localization of [125I]-IFN-gamma. Heparitin Sulfate 44-59 interferon gamma Homo sapiens 183-192 8836919-4 1996 We have shown recently that IFN-gamma-mediated effects can be blocked by heparin and that this inhibitory effect can be abrogated by the addition of protamine. Heparin 73-80 interferon gamma Homo sapiens 28-37 8836919-5 1996 In this report, we show that the antagonistic effect of protamine on heparin-mediated inhibition of IFN-gamma activity is mainly due to the capacity of protamine to enhance IFN-gamma activity. Heparin 69-76 interferon gamma Homo sapiens 100-109 8836919-5 1996 In this report, we show that the antagonistic effect of protamine on heparin-mediated inhibition of IFN-gamma activity is mainly due to the capacity of protamine to enhance IFN-gamma activity. Heparin 69-76 interferon gamma Homo sapiens 173-182 8818960-4 1996 Stimulation of PBMC induced low levels of interleukin 2 (IL-2), interferon gamma (IFN-gamma), IL-4, and IL-10 production. PBMC 15-19 interferon gamma Homo sapiens 64-91 8890975-1 1996 The effects of cytokines (interleukin-2, tumor necrosis factor-alpha and interferon-gamma) on the ability of peripheral blood monocytes and alveolar macrophages to produce oxygen radicals were examined by the chemiluminescence assay in patients with lung cancer. Reactive Oxygen Species 172-187 interferon gamma Homo sapiens 73-89 8675585-5 1996 In BHP cell lines, IFN gamma, IL-1 beta, and TGF beta 1 inhibited [3H]thymidine incorporation and decreased cell number, but TNF alpha stimulated [3H]thymidine incorporation. Tritium 67-69 interferon gamma Homo sapiens 19-28 8675585-5 1996 In BHP cell lines, IFN gamma, IL-1 beta, and TGF beta 1 inhibited [3H]thymidine incorporation and decreased cell number, but TNF alpha stimulated [3H]thymidine incorporation. Thymidine 70-79 interferon gamma Homo sapiens 19-28 8693287-5 1996 Anti-oestrogens, tamoxifen and toremifene, stimulated overall cytokine production on a B-cell line (Ball), whereas on a T-cell line (Molt-4) tamoxifen stimulated IL-1 beta, IL-6 and IFN-gamma production and toremifene inhibited it. Toremifene 31-41 interferon gamma Homo sapiens 182-191 8693287-5 1996 Anti-oestrogens, tamoxifen and toremifene, stimulated overall cytokine production on a B-cell line (Ball), whereas on a T-cell line (Molt-4) tamoxifen stimulated IL-1 beta, IL-6 and IFN-gamma production and toremifene inhibited it. Tamoxifen 141-150 interferon gamma Homo sapiens 182-191 8674529-0 1996 Interferon-gamma inhibits 35S incorporation in heparan sulfate synthesized by human skin fibroblasts. Sulfur-35 26-29 interferon gamma Homo sapiens 0-16 8674529-0 1996 Interferon-gamma inhibits 35S incorporation in heparan sulfate synthesized by human skin fibroblasts. Heparitin Sulfate 47-62 interferon gamma Homo sapiens 0-16 8674529-2 1996 Considering 3H incorporation, we found that IFNgamma increased the production of glycosaminoglycan synthesis, including hyaluronic acid, heparan and chondroitin/dermatan sulfate. Tritium 12-14 interferon gamma Homo sapiens 44-52 8674529-2 1996 Considering 3H incorporation, we found that IFNgamma increased the production of glycosaminoglycan synthesis, including hyaluronic acid, heparan and chondroitin/dermatan sulfate. Glycosaminoglycans 81-98 interferon gamma Homo sapiens 44-52 8674529-2 1996 Considering 3H incorporation, we found that IFNgamma increased the production of glycosaminoglycan synthesis, including hyaluronic acid, heparan and chondroitin/dermatan sulfate. Hyaluronic Acid 120-135 interferon gamma Homo sapiens 44-52 8674529-2 1996 Considering 3H incorporation, we found that IFNgamma increased the production of glycosaminoglycan synthesis, including hyaluronic acid, heparan and chondroitin/dermatan sulfate. heparan 137-144 interferon gamma Homo sapiens 44-52 8674529-2 1996 Considering 3H incorporation, we found that IFNgamma increased the production of glycosaminoglycan synthesis, including hyaluronic acid, heparan and chondroitin/dermatan sulfate. Chondroitin 149-160 interferon gamma Homo sapiens 44-52 8674529-2 1996 Considering 3H incorporation, we found that IFNgamma increased the production of glycosaminoglycan synthesis, including hyaluronic acid, heparan and chondroitin/dermatan sulfate. Dermatan Sulfate 161-177 interferon gamma Homo sapiens 44-52 8674529-5 1996 These data demonstrate that IFNgamma inhibits the incorporation of sulfate from extracellular medium into heparan sulfate. Sulfates 67-74 interferon gamma Homo sapiens 28-36 8674529-5 1996 These data demonstrate that IFNgamma inhibits the incorporation of sulfate from extracellular medium into heparan sulfate. Heparitin Sulfate 106-121 interferon gamma Homo sapiens 28-36 8764139-8 1996 We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets. Genistein 52-61 interferon gamma Homo sapiens 102-111 8764139-8 1996 We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets. herbimycin 66-78 interferon gamma Homo sapiens 102-111 8764139-8 1996 We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets. Dinoprostone 171-175 interferon gamma Homo sapiens 102-111 8764139-8 1996 We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets. Nitric Oxide 180-192 interferon gamma Homo sapiens 102-111 10851535-0 1996 Upregulation of DF3, in association with ICAM-1 and MHC class II by IFN-gamma in short-term human mammary carcinoma cell cultures. N-[2-(3-{[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]sulfanyl}-1H-indol-1-yl)ethyl]-3-(trifluoromethyl)benzamide 16-19 interferon gamma Homo sapiens 68-77 8676386-13 1996 In addition, helix A", which is interdigitated into the helical bundle in a manner similar to the helices in the CD loop of interferon-beta and interferon-gamma, exists in a region where short stretches of beta-structure are found at analogous positions in GM-CSF and IL-5. Cadmium 113-115 interferon gamma Homo sapiens 144-160 8635290-5 1996 IFN-gamma decreased (O2)- generation but increased scavenging enzyme induction. Superoxides 21-23 interferon gamma Homo sapiens 0-9 10851535-5 1996 Metastatic breast cancer cell cultures expressed high levels of DF3 and recombinant human IFN-gamma treatment, in vitro, upregulated ICAM-1 and MHC class II antigens before and after passage of the metastatic cells through the nude mouse. N-[2-(3-{[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]sulfanyl}-1H-indol-1-yl)ethyl]-3-(trifluoromethyl)benzamide 64-67 interferon gamma Homo sapiens 90-99 9099936-10 1996 Both spontaneous and up-regulated expression of ICAM-1, LFA-3 and VCAM-1 by IFN-gamma, IL-1beta or 12-o-tetradecanoyl phorbol 13-acetate (TPA) were markedly suppressed by clarithromycin in a dose-dependent manner at concentrations between 0.1 and 10 microg/ml. Clarithromycin 171-185 interferon gamma Homo sapiens 76-85 9099936-14 1996 As clarithromycin suppressed HLA-DR and costimulatory molecule expression was enhanced by IFN-gamma, autologous T cell proliferation was markedly inhibited by clarithromycin. Clarithromycin 3-17 interferon gamma Homo sapiens 90-99 8842524-4 1996 In contrast, HUVEC pretreated with 5000 U/mL of IFN-gamma for 24 h had both enhanced PGI2 production and increases in [Ca2+]i. Epoprostenol 85-89 interferon gamma Homo sapiens 48-57 8656550-2 1996 The authors have found that cancer patients showing marked IFN-gamma induction after inoculation with BCG-CWS (the cell wall skeleton from Bacille Calmette-Guerin) have a good prognosis. bcg-cws 102-109 interferon gamma Homo sapiens 59-68 8666806-4 1996 Only the PBHP-derived myelo-monocytic cells that were transduced with the IFN-gamma cDNA produced IFN-gamma(4 +/- 1.3 ng of IFN-gamma/10(6) PBHP cells.) 21-amino-6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-1,4,7,10,13,16,19-heptazacyclotricosane-2,5,8,11,14,17,20-heptone;sulfuric acid 9-13 interferon gamma Homo sapiens 74-83 8666806-4 1996 Only the PBHP-derived myelo-monocytic cells that were transduced with the IFN-gamma cDNA produced IFN-gamma(4 +/- 1.3 ng of IFN-gamma/10(6) PBHP cells.) 21-amino-6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-1,4,7,10,13,16,19-heptazacyclotricosane-2,5,8,11,14,17,20-heptone;sulfuric acid 9-13 interferon gamma Homo sapiens 98-107 8666806-4 1996 Only the PBHP-derived myelo-monocytic cells that were transduced with the IFN-gamma cDNA produced IFN-gamma(4 +/- 1.3 ng of IFN-gamma/10(6) PBHP cells.) 21-amino-6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-1,4,7,10,13,16,19-heptazacyclotricosane-2,5,8,11,14,17,20-heptone;sulfuric acid 9-13 interferon gamma Homo sapiens 98-107 8666806-6 1996 Monocytes differentiated from the IFN-gamma-transduced PBHP cells demonstrated 1) up-regulation of MHC class I and II Ag expression, 2) increased Fc(gamma)RI expression, and 3) enhanced superoxide production in response to both opsonized zymosan (25-fold) and phorbol ester (3-fold). 21-amino-6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-1,4,7,10,13,16,19-heptazacyclotricosane-2,5,8,11,14,17,20-heptone;sulfuric acid 55-59 interferon gamma Homo sapiens 34-43 8666806-6 1996 Monocytes differentiated from the IFN-gamma-transduced PBHP cells demonstrated 1) up-regulation of MHC class I and II Ag expression, 2) increased Fc(gamma)RI expression, and 3) enhanced superoxide production in response to both opsonized zymosan (25-fold) and phorbol ester (3-fold). Superoxides 186-196 interferon gamma Homo sapiens 34-43 8666806-6 1996 Monocytes differentiated from the IFN-gamma-transduced PBHP cells demonstrated 1) up-regulation of MHC class I and II Ag expression, 2) increased Fc(gamma)RI expression, and 3) enhanced superoxide production in response to both opsonized zymosan (25-fold) and phorbol ester (3-fold). Zymosan 238-245 interferon gamma Homo sapiens 34-43 8666806-6 1996 Monocytes differentiated from the IFN-gamma-transduced PBHP cells demonstrated 1) up-regulation of MHC class I and II Ag expression, 2) increased Fc(gamma)RI expression, and 3) enhanced superoxide production in response to both opsonized zymosan (25-fold) and phorbol ester (3-fold). Phorbol Esters 260-273 interferon gamma Homo sapiens 34-43 8662795-6 1996 Stat1 activation by interferon-gamma is mediated through a cytosolic tyrosine motif, Y440, of the interferon-gamma receptor. Tyrosine 69-77 interferon gamma Homo sapiens 20-36 8786998-0 1996 Computer-aided modeling of structure stabilizing disulfide bonds in recombinant human interferon-gamma. Disulfides 49-58 interferon gamma Homo sapiens 86-102 8662591-11 1996 We compare the APRF and STAT1 activation motifs of gp130 with the STAT1 activation motif of the IFNgamma receptor and demonstrate that the specificity of activation can be changed from APRF to STAT1 and vice versa by only two point mutations within a tyrosine module. Tyrosine 251-259 interferon gamma Homo sapiens 96-104 8662795-6 1996 Stat1 activation by interferon-gamma is mediated through a cytosolic tyrosine motif, Y440, of the interferon-gamma receptor. Tyrosine 69-77 interferon gamma Homo sapiens 98-114 8662795-12 1996 Furthermore, the SH2 domain of Stat1 is able to recognize two unrelated types of phosphotyrosine motifs, one represented by the interferon-gamma receptor Y440DKPH peptide, and the other by two gp130 YXPQ motifs. Phosphotyrosine 81-96 interferon gamma Homo sapiens 128-144 8660811-0 1996 Dual control of human interleukin-2 and interferon-gamma gene expression by histamine: activation and suppression. Histamine 76-85 interferon gamma Homo sapiens 40-56 8660811-2 1996 In agreement with this concept, we show that histamine elicits a strong inhibition of the induced expression of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) genes. Histamine 45-54 interferon gamma Homo sapiens 137-153 8660811-2 1996 In agreement with this concept, we show that histamine elicits a strong inhibition of the induced expression of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) genes. Histamine 45-54 interferon gamma Homo sapiens 155-164 8660811-7 1996 The dual effect of histamine can be blocked by the H2 histamine receptor antagonist cimetidine, while the early activation by histamine is mimicked by the H2 agonist impromidine, showing that both activation and inhibition of IL-2 and IFN-gamma gene expression by histamine are exerted via this receptor. Impromidine 166-177 interferon gamma Homo sapiens 235-244 8660811-8 1996 These results support the concept that histamine, released during an immune response, exerts opposite regulatory effects by first activating cells able to express the IL-2 and IFN-gamma genes and only then suppressive cells that become responsive to histamine more slowly, but once activated shut off the expression of these genes. Histamine 39-48 interferon gamma Homo sapiens 176-185 8626684-0 1996 Nitric oxide attenuates vascular smooth muscle cell activation by interferon-gamma. Nitric Oxide 0-12 interferon gamma Homo sapiens 66-82 8782901-6 1996 Among the various cytokines investigated such as interleukin-1, interleukin-6, tumor necrosis factor-alpha and interferon-gamma (IFN-gamma), only IFN-gamma markedly enhanced A beta-dependent nitrite production. Nitrites 191-198 interferon gamma Homo sapiens 129-138 8782901-6 1996 Among the various cytokines investigated such as interleukin-1, interleukin-6, tumor necrosis factor-alpha and interferon-gamma (IFN-gamma), only IFN-gamma markedly enhanced A beta-dependent nitrite production. Nitrites 191-198 interferon gamma Homo sapiens 146-155 8782901-8 1996 Neurotoxicity caused by the A beta plus IFN-gamma-stimulated microglial cells was significantly attenuated by NMMA. omega-N-Methylarginine 110-114 interferon gamma Homo sapiens 40-49 8724037-5 1996 Moreover, PTX reduced TNF-alpha, IFN-gamma and IL-10 production and NF-kappa B activation. Pentoxifylline 10-13 interferon gamma Homo sapiens 33-42 8621263-8 1996 Protective effects of IFN-gamma on target cell sensitivity to lysis were blocked by pre-treatment of target cells with actinomycin-D or cycloheximide. Dactinomycin 119-132 interferon gamma Homo sapiens 22-31 8621263-8 1996 Protective effects of IFN-gamma on target cell sensitivity to lysis were blocked by pre-treatment of target cells with actinomycin-D or cycloheximide. Cycloheximide 136-149 interferon gamma Homo sapiens 22-31 8724037-6 1996 PTX inhibited with similar potency IFN-gamma, TNF-alpha and cell proliferation. Pentoxifylline 0-3 interferon gamma Homo sapiens 35-44 8783018-2 1996 Sodium dodecyl sulfate-polyacrylamide get electrophoresis (SDS-PAGE) of natural, human interferon-gamma (IFN-gamma) showed two glycosylated variants with apparent molecular masses of 20 and 24 kDa. Sodium Dodecyl Sulfate 0-22 interferon gamma Homo sapiens 87-103 8815742-1 1996 An analytical system is presented for rapid assessment of site-specific microheterogeneity of the two potential N-linked glycosylation sites of recombinant human interferon-gamma (IFN-gamma) derived from Chinese hamster ovary cell culture. Nitrogen 112-113 interferon gamma Homo sapiens 162-178 8815742-1 1996 An analytical system is presented for rapid assessment of site-specific microheterogeneity of the two potential N-linked glycosylation sites of recombinant human interferon-gamma (IFN-gamma) derived from Chinese hamster ovary cell culture. Nitrogen 112-113 interferon gamma Homo sapiens 180-189 8783018-2 1996 Sodium dodecyl sulfate-polyacrylamide get electrophoresis (SDS-PAGE) of natural, human interferon-gamma (IFN-gamma) showed two glycosylated variants with apparent molecular masses of 20 and 24 kDa. Sodium Dodecyl Sulfate 0-22 interferon gamma Homo sapiens 105-114 8783018-2 1996 Sodium dodecyl sulfate-polyacrylamide get electrophoresis (SDS-PAGE) of natural, human interferon-gamma (IFN-gamma) showed two glycosylated variants with apparent molecular masses of 20 and 24 kDa. polyacrylamide 23-37 interferon gamma Homo sapiens 87-103 8783018-2 1996 Sodium dodecyl sulfate-polyacrylamide get electrophoresis (SDS-PAGE) of natural, human interferon-gamma (IFN-gamma) showed two glycosylated variants with apparent molecular masses of 20 and 24 kDa. polyacrylamide 23-37 interferon gamma Homo sapiens 105-114 8783018-2 1996 Sodium dodecyl sulfate-polyacrylamide get electrophoresis (SDS-PAGE) of natural, human interferon-gamma (IFN-gamma) showed two glycosylated variants with apparent molecular masses of 20 and 24 kDa. Sodium Dodecyl Sulfate 59-62 interferon gamma Homo sapiens 87-103 8783018-2 1996 Sodium dodecyl sulfate-polyacrylamide get electrophoresis (SDS-PAGE) of natural, human interferon-gamma (IFN-gamma) showed two glycosylated variants with apparent molecular masses of 20 and 24 kDa. Sodium Dodecyl Sulfate 59-62 interferon gamma Homo sapiens 105-114 8783018-4 1996 The peptide map obtained by MALDI-MS after digestion in the gel covers 92% of the IFN-gamma sequence and revealed an N-terminal pyroglutamate residue and one oxidized methionine residue. Pyrrolidonecarboxylic Acid 128-141 interferon gamma Homo sapiens 82-91 8617947-8 1996 IFN-gamma was secreted in cultures containing rIL-12, whereas IL-5 secretion was dependent upon interaction of IL-2 with the high affinity IL-2R. ril-12 46-52 interferon gamma Homo sapiens 0-9 8616835-3 1996 IFN-gamma was found to be a potent inducer of nitric oxide production in DLD-1 cells. Nitric Oxide 46-58 interferon gamma Homo sapiens 0-9 8616835-7 1996 Treatment of DLD-1 cells with concentrations of 5-FUra that are not growth inhibitory or cytotoxic strongly inhibited their ability to express nitric oxide synthase and produce nitric oxide in response to IFN-gamma. Fluorouracil 48-54 interferon gamma Homo sapiens 205-214 8616835-9 1996 However, pretreatment of DLD-1 cells with 5-FUra before stimulation with IFN-gamma also suppressed nitric oxide production. Nitric Oxide 99-111 interferon gamma Homo sapiens 73-82 8613467-1 1996 L-thyroxine (L-T4) potentiates the antiviral activity of human interferon-gamma (IFN-gamma) in HeLa cells. Thyroxine 0-11 interferon gamma Homo sapiens 63-79 8613467-1 1996 L-thyroxine (L-T4) potentiates the antiviral activity of human interferon-gamma (IFN-gamma) in HeLa cells. Thyroxine 0-11 interferon gamma Homo sapiens 81-90 8613467-1 1996 L-thyroxine (L-T4) potentiates the antiviral activity of human interferon-gamma (IFN-gamma) in HeLa cells. Thyroxine 13-17 interferon gamma Homo sapiens 63-79 8613467-1 1996 L-thyroxine (L-T4) potentiates the antiviral activity of human interferon-gamma (IFN-gamma) in HeLa cells. Thyroxine 13-17 interferon gamma Homo sapiens 81-90 8613467-4 1996 L-T4 potentiated the antiviral action of IFN-gamma by a reduction in virus yield of more than two logs, the equivalent of a more than 100-fold potentiation of the IFN"s antiviral effect. Thyroxine 0-4 interferon gamma Homo sapiens 41-50 8613467-6 1996 3,3",5-L-triiodothyronine (L-T3) was as effective as L-T4 when coincubated for 24 h with IFN-gamma but was less effective than L-T4 when coincubated for only 4 h. D-T4, D-T3, 3,3",5-triiodothyroacetic acid (triac), tetraiodothyroacetic acid (tetrac), and 3,5-diiodothyronine (T2) were inactive. Triiodothyronine, Reverse 0-25 interferon gamma Homo sapiens 89-98 8613467-6 1996 3,3",5-L-triiodothyronine (L-T3) was as effective as L-T4 when coincubated for 24 h with IFN-gamma but was less effective than L-T4 when coincubated for only 4 h. D-T4, D-T3, 3,3",5-triiodothyroacetic acid (triac), tetraiodothyroacetic acid (tetrac), and 3,5-diiodothyronine (T2) were inactive. Triiodothyronine 27-31 interferon gamma Homo sapiens 89-98 8613467-6 1996 3,3",5-L-triiodothyronine (L-T3) was as effective as L-T4 when coincubated for 24 h with IFN-gamma but was less effective than L-T4 when coincubated for only 4 h. D-T4, D-T3, 3,3",5-triiodothyroacetic acid (triac), tetraiodothyroacetic acid (tetrac), and 3,5-diiodothyronine (T2) were inactive. Thyroxine 53-57 interferon gamma Homo sapiens 89-98 8613467-8 1996 3,3",5-L-triiodothyronine (rT3) also potentiated the antiviral action of IFN-gamma, but only in the preincubation model. Triiodothyronine, Reverse 0-25 interferon gamma Homo sapiens 73-82 8613467-8 1996 3,3",5-L-triiodothyronine (rT3) also potentiated the antiviral action of IFN-gamma, but only in the preincubation model. Triiodothyronine, Reverse 27-30 interferon gamma Homo sapiens 73-82 8613467-10 1996 When L-T4, L-T3, or rT3, plus cycloheximide (5 micrograms/ml), was added to cells for 24 h and then removed prior to 24 h IFN-gamma exposure, the potentiating effect of the three iodothyronines was completely inhibited. Thyroxine 5-9 interferon gamma Homo sapiens 122-131 8613467-10 1996 When L-T4, L-T3, or rT3, plus cycloheximide (5 micrograms/ml), was added to cells for 24 h and then removed prior to 24 h IFN-gamma exposure, the potentiating effect of the three iodothyronines was completely inhibited. Triiodothyronine 11-15 interferon gamma Homo sapiens 122-131 8816327-6 1996 In addition, the HSP and PGE2 treatment used inhibited the production of the Th1 cytokines IL-2 and IFNg but had a differential modulatory effect on Th2 cytokine production, namely enhancing the production of IL-6 whilst simultaneously impairing the synthesis of IL-4 and IL-10. Dinoprostone 25-29 interferon gamma Homo sapiens 100-104 8727074-7 1996 Superoxide production was enhanced to the greatest degree by IFN-gamma, followed by IFN-beta and then IFN-gamma. Superoxides 0-10 interferon gamma Homo sapiens 61-70 8727074-7 1996 Superoxide production was enhanced to the greatest degree by IFN-gamma, followed by IFN-beta and then IFN-gamma. Superoxides 0-10 interferon gamma Homo sapiens 102-111 8727075-0 1996 Effect of therapy with recombinant human interferon-gamma on the release of nitric oxide by neutrophils and mononuclear cells from patients with chronic granulomatous disease. Nitric Oxide 76-88 interferon gamma Homo sapiens 41-57 8727075-1 1996 The aim of this study was to investigate the effect of recombinant human interferon-gamma (rHuIFN-gamma) therapy on the release of nitric oxide (NO) by neutrophils (NEU) and mononuclear cells (MON) from patients with chronic granulomatous disease (CGD). Nitric Oxide 131-143 interferon gamma Homo sapiens 73-89 8612815-3 1996 PARP cleavage in response to lipopolysaccharide and interferon-gamma treatment is prevented by NG-monomethyl-L-arginine, thus proving a NO requirement. omega-N-Methylarginine 95-119 interferon gamma Homo sapiens 52-68 8609410-7 1996 BmA-stimulated supernatants pretreated with anti-IL-1 alone resulted in VCAM-1 expression that was 23.7% of that with untreated supernatants while anti-IL-4, anti-IFN-gamma, or anti-TNF alone had essentially no effect on VCAM-1 expression. bma 0-3 interferon gamma Homo sapiens 163-172 8600944-5 1996 Dexamethasone (DEX) inhibited the anti-CD3-induced production of IL-4, IL-5 and IFN-gamma in all 20 clones tested. Dexamethasone 0-13 interferon gamma Homo sapiens 80-89 8600944-5 1996 Dexamethasone (DEX) inhibited the anti-CD3-induced production of IL-4, IL-5 and IFN-gamma in all 20 clones tested. Dexamethasone 15-18 interferon gamma Homo sapiens 80-89 8600944-7 1996 DEX enhanced the ratio IFN-gamma/IL-4 (mean +/- SEM: control, 28.7 +/- 17.6; with 10-7 M DEX, 55.0 +/- 27.5, P<0.005). Dexamethasone 0-3 interferon gamma Homo sapiens 23-32 8928785-2 1996 Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein. Genistein 114-123 interferon gamma Homo sapiens 66-82 8928785-2 1996 Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein. pyrrolidine dithiocarbamic acid 125-152 interferon gamma Homo sapiens 66-82 8928785-2 1996 Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein. Dexamethasone 157-170 interferon gamma Homo sapiens 66-82 8928785-2 1996 Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein. Egtazic Acid 207-277 interferon gamma Homo sapiens 66-82 8928785-2 1996 Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein. Isoflavones 356-366 interferon gamma Homo sapiens 66-82 8928785-2 1996 Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein. daidzein 367-375 interferon gamma Homo sapiens 66-82 8645468-0 1996 Interferon-gamma increases inositol phosphate formation and cellular calcium ion concentration independent of ICAM-1 antigen enhancement in renal tubular cells. Inositol Phosphates 27-45 interferon gamma Homo sapiens 0-16 8645468-0 1996 Interferon-gamma increases inositol phosphate formation and cellular calcium ion concentration independent of ICAM-1 antigen enhancement in renal tubular cells. Calcium 69-76 interferon gamma Homo sapiens 0-16 8645468-1 1996 In the present study, we investigated the effect of interferon-gamma (IFN-gamma) on cellular inositol phosphate formation and cellular calcium ion concentration [Ca2+]i in human renal proximal tubular (HRPT) cells. Inositol Phosphates 93-111 interferon gamma Homo sapiens 52-68 8645468-1 1996 In the present study, we investigated the effect of interferon-gamma (IFN-gamma) on cellular inositol phosphate formation and cellular calcium ion concentration [Ca2+]i in human renal proximal tubular (HRPT) cells. Inositol Phosphates 93-111 interferon gamma Homo sapiens 70-79 8645468-2 1996 We also examined the possible role of the inositol phosphate-Ca2+ signalling pathway during IFN-gamma-induced intercellular adhesion molecule-1 (ICAM-1) antigen expression. Inositol Phosphates 42-60 interferon gamma Homo sapiens 92-101 8645468-3 1996 IFN-gamma caused an increase in the formation of inositol 1-monophosphate (Ins 1-P), inositol 1,4-bisphosphate (Ins 1,4-P2), inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) and inositol 1,3,4,5-tetrakisphosphate (Ins 1,3,4,5-P4). inositol 1-phosphate 49-73 interferon gamma Homo sapiens 0-9 8645468-3 1996 IFN-gamma caused an increase in the formation of inositol 1-monophosphate (Ins 1-P), inositol 1,4-bisphosphate (Ins 1,4-P2), inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) and inositol 1,3,4,5-tetrakisphosphate (Ins 1,3,4,5-P4). inositol 1-phosphate 75-82 interferon gamma Homo sapiens 0-9 8645468-3 1996 IFN-gamma caused an increase in the formation of inositol 1-monophosphate (Ins 1-P), inositol 1,4-bisphosphate (Ins 1,4-P2), inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) and inositol 1,3,4,5-tetrakisphosphate (Ins 1,3,4,5-P4). inositol 1,4-bis(phosphate) 85-110 interferon gamma Homo sapiens 0-9 8645468-3 1996 IFN-gamma caused an increase in the formation of inositol 1-monophosphate (Ins 1-P), inositol 1,4-bisphosphate (Ins 1,4-P2), inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) and inositol 1,3,4,5-tetrakisphosphate (Ins 1,3,4,5-P4). ins 1,4-p2 112-122 interferon gamma Homo sapiens 0-9 8645468-3 1996 IFN-gamma caused an increase in the formation of inositol 1-monophosphate (Ins 1-P), inositol 1,4-bisphosphate (Ins 1,4-P2), inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) and inositol 1,3,4,5-tetrakisphosphate (Ins 1,3,4,5-P4). Inositol 1,4,5-Trisphosphate 125-153 interferon gamma Homo sapiens 0-9 8645468-3 1996 IFN-gamma caused an increase in the formation of inositol 1-monophosphate (Ins 1-P), inositol 1,4-bisphosphate (Ins 1,4-P2), inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) and inositol 1,3,4,5-tetrakisphosphate (Ins 1,3,4,5-P4). Inositol 1,4,5-Trisphosphate 155-167 interferon gamma Homo sapiens 0-9 8645468-3 1996 IFN-gamma caused an increase in the formation of inositol 1-monophosphate (Ins 1-P), inositol 1,4-bisphosphate (Ins 1,4-P2), inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) and inositol 1,3,4,5-tetrakisphosphate (Ins 1,3,4,5-P4). inositol-1,3,4,5-tetrakisphosphate 173-207 interferon gamma Homo sapiens 0-9 8645468-3 1996 IFN-gamma caused an increase in the formation of inositol 1-monophosphate (Ins 1-P), inositol 1,4-bisphosphate (Ins 1,4-P2), inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) and inositol 1,3,4,5-tetrakisphosphate (Ins 1,3,4,5-P4). inositol-1,3,4,5-tetrakisphosphate 209-223 interferon gamma Homo sapiens 0-9 8645468-6 1996 This correlated with the generation of Ins 1,4,5-P3 by IFN-gamma, a well-known secondary messenger capable of releasing Ca2+ from intracellular stores. Inositol 1,4,5-Trisphosphate 39-51 interferon gamma Homo sapiens 55-64 8645468-9 1996 In conclusion, our data suggest that IFN-gamma stimulation of HRPT cells results in the cleavage of phosphatidylinositol bisphosphate by phospholipase C, generating inositol phosphates, of which Ins 1,4,5-P3 probably releases Ca2+ from intracellular stores. phosphatidylinositol bisphosphate 100-133 interferon gamma Homo sapiens 37-46 8645468-9 1996 In conclusion, our data suggest that IFN-gamma stimulation of HRPT cells results in the cleavage of phosphatidylinositol bisphosphate by phospholipase C, generating inositol phosphates, of which Ins 1,4,5-P3 probably releases Ca2+ from intracellular stores. Inositol Phosphates 165-184 interferon gamma Homo sapiens 37-46 8645468-9 1996 In conclusion, our data suggest that IFN-gamma stimulation of HRPT cells results in the cleavage of phosphatidylinositol bisphosphate by phospholipase C, generating inositol phosphates, of which Ins 1,4,5-P3 probably releases Ca2+ from intracellular stores. Inositol 1,4,5-Trisphosphate 195-207 interferon gamma Homo sapiens 37-46 8967788-5 1996 Il-6 levels were slightly elevated in the supernatants obtained from psoriatic and control keratinocyte cultures after lithium treatment, but IFN gamma and Il-2 levels were elevated only in the lithium-treated cocultures with psoriatic keratinocytes. Lithium 194-201 interferon gamma Homo sapiens 142-151 8967788-8 1996 We therefore demonstrated that lithium influences the cell communication of psoriatic keratinocytes with HUT 78 lymphocytes by triggering the secretion of TGF alpha, Il-2 and, massively, IFN gamma. Lithium 31-38 interferon gamma Homo sapiens 187-196 8639901-5 1996 Actinomycin D and 5,6-dichloro-1-beta-ribofuranosylbenzimidazole abolished IFN-gamma-induced C1 INH mRNA expression. Dactinomycin 0-13 interferon gamma Homo sapiens 75-84 8639901-5 1996 Actinomycin D and 5,6-dichloro-1-beta-ribofuranosylbenzimidazole abolished IFN-gamma-induced C1 INH mRNA expression. Dichlororibofuranosylbenzimidazole 18-64 interferon gamma Homo sapiens 75-84 8639901-7 1996 Treatment of HepG2 cells with the phosphatase 1 and 2A inhibitors, okadaic acid (> or = 50 nmol/L) and calyculin (> or = 25 nmol/L), decreased IFN-gamma"s ability to upregulated C1 INH mRNA. Okadaic Acid 67-79 interferon gamma Homo sapiens 149-158 8639901-8 1996 The phosphatase 2A inhibitor, cantharidin (> or = 10 micromol/L), also blocked the IFN-gamma induction of the C1 INH gene. Cantharidin 30-41 interferon gamma Homo sapiens 86-95 8603535-4 1996 In this study it is shown that the effects of interferon-gamma (IFN-gamma), but not of tumour necrosis factor-alpha (TNF-alpha), are inhibited by treatment with soluble heparin. Heparin 169-176 interferon gamma Homo sapiens 46-62 8603535-4 1996 In this study it is shown that the effects of interferon-gamma (IFN-gamma), but not of tumour necrosis factor-alpha (TNF-alpha), are inhibited by treatment with soluble heparin. Heparin 169-176 interferon gamma Homo sapiens 64-73 8603535-5 1996 Specifically, heparin was shown to inhibit the induction of class II MHC antigens and the up-regulation of intercellular adhesion molecule-1 (ICAM-1) produced by treatment of cultured human endothelial cells with IFN-gamma. Heparin 14-21 interferon gamma Homo sapiens 213-222 8603535-6 1996 Furthermore, it was shown that heparin blocked the enhanced adhesion of T lymphocytes to IFN-gamma-treated endothelial cells. Heparin 31-38 interferon gamma Homo sapiens 89-98 8603535-8 1996 These results may explain reported immunosuppressive properties of heparin, and are consistent with the model that heparin may compete with cell surface GAGs to bind IFN-gamma, thereby reducing effective biological activity. Heparin 67-74 interferon gamma Homo sapiens 166-175 8603535-8 1996 These results may explain reported immunosuppressive properties of heparin, and are consistent with the model that heparin may compete with cell surface GAGs to bind IFN-gamma, thereby reducing effective biological activity. Heparin 115-122 interferon gamma Homo sapiens 166-175 8935335-0 1996 Alteration of human melanoma gangliosides by IFN-gamma, IL-2, and IL-4. Gangliosides 29-41 interferon gamma Homo sapiens 45-54 8613697-5 1996 This IFN-gamma potentiates antigen-presenting cell functions important in clearing infections agents (phagocytosis, oxidative burst, and production of nitrous oxide) and also increases further production of IL-12. Nitrous Oxide 151-164 interferon gamma Homo sapiens 5-14 8935335-4 1996 IFN-gamma increases the ratio of a-series gangliosides and the ratio of GM3/GD3. Gangliosides 42-54 interferon gamma Homo sapiens 0-9 8935335-4 1996 IFN-gamma increases the ratio of a-series gangliosides and the ratio of GM3/GD3. gm3 72-75 interferon gamma Homo sapiens 0-9 8935335-4 1996 IFN-gamma increases the ratio of a-series gangliosides and the ratio of GM3/GD3. ganglioside, GD3 76-79 interferon gamma Homo sapiens 0-9 8613948-6 1996 Budesonide (10(-7) M) dramatically reduced A-PBM proliferation (measured by 3H-thymidine incorporation) and cytokine (IL-1beta, IL-2, IL-6, IFN-gamma, TNF-alpha) production, but was not cytotoxic to immune cells. Budesonide 0-10 interferon gamma Homo sapiens 140-149 8691726-5 1996 Cytoflurography demonstrated Fas expression on the surface of human mesangial cells that was increased by stimulation with interferon gamma (IFN gamma). ammonium ferrous sulfate 29-32 interferon gamma Homo sapiens 123-150 8691260-4 1996 RESULTS: In 8 of 12 papillary and all 2 follicular carcinomas, interferon-gamma significantly stimulated iodine incorporation. Iodine 105-111 interferon gamma Homo sapiens 63-79 8657115-4 1996 Phorbol ester treatment of monocytes inhibited IFN alpha-stimulated tyrosine phosphorylation of the transcription factors Stat1alpha, Stat2, and Stat3 and of the tyrosine kinase Tyk2 but had no effect on IFN-gamma activation of Stat1alpha. Phorbol Esters 0-13 interferon gamma Homo sapiens 204-213 9345430-4 1996 The counteracting effect of IFN-alpha/IFN-beta against IFN-gamma-induced astrocytic proliferation was verified by the DNA content distribution analysis of propidium iodide-labeled cells. Propidium 155-171 interferon gamma Homo sapiens 55-64 8743107-4 1996 Autoserum regulated IFNg production in a stage-dependent way: it decreased IFNg activity at the bilirubin peak in hepatitis B infection, but not in convalescence. Bilirubin 96-105 interferon gamma Homo sapiens 20-24 8743107-4 1996 Autoserum regulated IFNg production in a stage-dependent way: it decreased IFNg activity at the bilirubin peak in hepatitis B infection, but not in convalescence. Bilirubin 96-105 interferon gamma Homo sapiens 75-79 8623163-0 1996 Identification of a calcium-inducible, cyclosporine sensitive element in the IFN-gamma promoter that is a potential NFAT binding site. Calcium 20-27 interferon gamma Homo sapiens 77-86 8661340-1 1996 The commonly used antidepressants imipramine, amitriptyline, and nortriptyline were found to significantly inhibit human natural killer (NK) cell-mediated cytolysis in vitro and suppress the stimulation of NK cells by IFN-gamma. Imipramine 34-44 interferon gamma Homo sapiens 218-227 8661340-1 1996 The commonly used antidepressants imipramine, amitriptyline, and nortriptyline were found to significantly inhibit human natural killer (NK) cell-mediated cytolysis in vitro and suppress the stimulation of NK cells by IFN-gamma. Amitriptyline 46-59 interferon gamma Homo sapiens 218-227 8661340-1 1996 The commonly used antidepressants imipramine, amitriptyline, and nortriptyline were found to significantly inhibit human natural killer (NK) cell-mediated cytolysis in vitro and suppress the stimulation of NK cells by IFN-gamma. Nortriptyline 65-78 interferon gamma Homo sapiens 218-227 8623163-0 1996 Identification of a calcium-inducible, cyclosporine sensitive element in the IFN-gamma promoter that is a potential NFAT binding site. Cyclosporine 39-51 interferon gamma Homo sapiens 77-86 8623163-10 1996 These results suggest that the P2 sequence, and probably the P1 sequence, in the IFN-gamma promoter are NFAT binding sites and contribute to the calcium inducibility and CsA sensitivity of IFN-gamma production. Calcium 145-152 interferon gamma Homo sapiens 81-90 8724659-4 1996 Dexamethasone inhibited the induction of iNOS mRNA by IFN-gamma and TNF-alpha. Dexamethasone 0-13 interferon gamma Homo sapiens 54-63 8630399-6 1996 This apoptosis-inhibitory effect of vesnarinone was associated with the blocking of CD4XL-induced TNF-alpha IFN-gamma secretion and of Fas antigen upregulation. vesnarinone 36-47 interferon gamma Homo sapiens 108-117 8630399-6 1996 This apoptosis-inhibitory effect of vesnarinone was associated with the blocking of CD4XL-induced TNF-alpha IFN-gamma secretion and of Fas antigen upregulation. cd4xl 84-89 interferon gamma Homo sapiens 108-117 8630399-8 1996 These data suggest that vesnarinone inhibits CD4XL-induced TNF-alpha/IFN-gamma secretion, thereby blocking subsequent Fas upregulation and apoptosis induction. vesnarinone 24-35 interferon gamma Homo sapiens 69-78 8630399-8 1996 These data suggest that vesnarinone inhibits CD4XL-induced TNF-alpha/IFN-gamma secretion, thereby blocking subsequent Fas upregulation and apoptosis induction. cd4xl 45-50 interferon gamma Homo sapiens 69-78 8623163-10 1996 These results suggest that the P2 sequence, and probably the P1 sequence, in the IFN-gamma promoter are NFAT binding sites and contribute to the calcium inducibility and CsA sensitivity of IFN-gamma production. Calcium 145-152 interferon gamma Homo sapiens 189-198 8623163-10 1996 These results suggest that the P2 sequence, and probably the P1 sequence, in the IFN-gamma promoter are NFAT binding sites and contribute to the calcium inducibility and CsA sensitivity of IFN-gamma production. Cyclosporine 170-173 interferon gamma Homo sapiens 81-90 8623163-10 1996 These results suggest that the P2 sequence, and probably the P1 sequence, in the IFN-gamma promoter are NFAT binding sites and contribute to the calcium inducibility and CsA sensitivity of IFN-gamma production. Cyclosporine 170-173 interferon gamma Homo sapiens 189-198 8609251-2 1996 The addition of interferon gamma to cyclosporine, given to induce graft-versus-host disease after autologous bone marrow transplantation, increases the extent of the cutaneous eruption. Cyclosporine 36-48 interferon gamma Homo sapiens 16-32 8845179-13 1996 Addition of colchicine increased the release of TNF-sR75 induced by LPS and IFN-gamma, but not by PMA. Colchicine 12-22 interferon gamma Homo sapiens 76-85 8598153-0 1996 Beryllium stimulates release of T helper 1 cytokines interleukin-2 and interferon gamma from BAL cells in chronic beryllium disease. Beryllium 0-9 interferon gamma Homo sapiens 71-87 8598153-0 1996 Beryllium stimulates release of T helper 1 cytokines interleukin-2 and interferon gamma from BAL cells in chronic beryllium disease. Beryllium 114-123 interferon gamma Homo sapiens 71-87 8796447-0 1996 Salmeterol inhibits interferon-gamma and interleukin-4 production by human peripheral blood mononuclear cells. Salmeterol Xinafoate 0-10 interferon gamma Homo sapiens 20-36 8796447-9 1996 Similar to the results obtained after 24 h, IFN-gamma production after 96 h was biphasically inhibited by salmeterol, and this inhibition (60%) was significantly at 10(-5) M. Together, the present data provide clear evidence for concentration-dependent effects of beta-adrenoceptor agonists on the IL-4 and IFN-gamma production by human PBMC. Salmeterol Xinafoate 106-116 interferon gamma Homo sapiens 44-53 8796447-9 1996 Similar to the results obtained after 24 h, IFN-gamma production after 96 h was biphasically inhibited by salmeterol, and this inhibition (60%) was significantly at 10(-5) M. Together, the present data provide clear evidence for concentration-dependent effects of beta-adrenoceptor agonists on the IL-4 and IFN-gamma production by human PBMC. Salmeterol Xinafoate 106-116 interferon gamma Homo sapiens 307-316 8596019-0 1996 Accessory cell-derived IL-12 and prostaglandin E2 determine the IFN-gamma level of activated human CD4+ T cells. Dinoprostone 33-49 interferon gamma Homo sapiens 64-73 8596019-6 1996 Because the net IFN-gamma production of CD4+ T cells is largely determined by the ratio of IL-12 and PGE2 at the timepoint of T cell activation, an imbalance in the production of these immunomodulators may, therefore, lead to immunologic dysfunction. Dinoprostone 101-105 interferon gamma Homo sapiens 16-25 8762005-10 1996 Likewise, the induction of IFN-gamma and IL-2 mRNA by calcium ionophore A23187 was inhibited with IC50 of 14 ng/ml (95% CI = 8-27 ng/ml) and 32 ng/ml (95% CI = 5-178 ng/ml), respectively, while the IC50 for inhibition of IFN-gamma protein secretion was 8 ng/ml (95% CI = 9-18 ng/ml). Calcium 54-61 interferon gamma Homo sapiens 27-36 8598544-7 1996 In parallel experiments, where monocytes were simultaneously activated by the addition of interferon-gamma to the cultures, median expression intensities of HLA-DR, -DP and ICAM-1 were significantly lower in the presence of either EPA or DHA compared with incubations without the (n-3) PUFA. dp 166-168 interferon gamma Homo sapiens 90-106 8598544-7 1996 In parallel experiments, where monocytes were simultaneously activated by the addition of interferon-gamma to the cultures, median expression intensities of HLA-DR, -DP and ICAM-1 were significantly lower in the presence of either EPA or DHA compared with incubations without the (n-3) PUFA. Eicosapentaenoic Acid 231-234 interferon gamma Homo sapiens 90-106 8598544-7 1996 In parallel experiments, where monocytes were simultaneously activated by the addition of interferon-gamma to the cultures, median expression intensities of HLA-DR, -DP and ICAM-1 were significantly lower in the presence of either EPA or DHA compared with incubations without the (n-3) PUFA. Docosahexaenoic Acids 238-241 interferon gamma Homo sapiens 90-106 8762005-10 1996 Likewise, the induction of IFN-gamma and IL-2 mRNA by calcium ionophore A23187 was inhibited with IC50 of 14 ng/ml (95% CI = 8-27 ng/ml) and 32 ng/ml (95% CI = 5-178 ng/ml), respectively, while the IC50 for inhibition of IFN-gamma protein secretion was 8 ng/ml (95% CI = 9-18 ng/ml). Calcium 54-61 interferon gamma Homo sapiens 221-230 8762005-10 1996 Likewise, the induction of IFN-gamma and IL-2 mRNA by calcium ionophore A23187 was inhibited with IC50 of 14 ng/ml (95% CI = 8-27 ng/ml) and 32 ng/ml (95% CI = 5-178 ng/ml), respectively, while the IC50 for inhibition of IFN-gamma protein secretion was 8 ng/ml (95% CI = 9-18 ng/ml). Calcimycin 72-78 interferon gamma Homo sapiens 27-36 8762005-10 1996 Likewise, the induction of IFN-gamma and IL-2 mRNA by calcium ionophore A23187 was inhibited with IC50 of 14 ng/ml (95% CI = 8-27 ng/ml) and 32 ng/ml (95% CI = 5-178 ng/ml), respectively, while the IC50 for inhibition of IFN-gamma protein secretion was 8 ng/ml (95% CI = 9-18 ng/ml). Calcimycin 72-78 interferon gamma Homo sapiens 221-230 8599841-2 1996 Schwann cells treated with IFN-gamma and TNF-alpha upregulated iNOS-specific mRNA within 12 hr and released nitrite in a time- and dose-dependent manner, reaching a plateau of secretion after 3 days. Nitrites 108-115 interferon gamma Homo sapiens 27-36 8650265-1 1996 IRS-signalling proteins are engaged and phosphorylated on tyrosine residues by the receptors for insulin and IGF-1, and various classes of cytokine receptors, including IL-4, IL-9, and IL-13; IFN alpha/beta and IFN gamma; and growth hormone and LIF. Tyrosine 58-66 interferon gamma Homo sapiens 211-220 8643683-2 1996 Quin immunoreactivity (Quin-IR) was increased in gamma interferon (IFN-gamma)-stimulated monocytes/macrophages (MOs). Quinolinic Acid 0-4 interferon gamma Homo sapiens 49-76 8851175-3 1996 Interestingly, when EoL-1 cells were treated with interferon-gamma, mRNAs for muscarinic M3 and M5 receptors could be detected in these cells, along with an increase in [Ca2+]i and chemotaxis induced by carbachol that could be blocked with 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) and pirenzepine. Carbachol 203-212 interferon gamma Homo sapiens 50-66 8851175-3 1996 Interestingly, when EoL-1 cells were treated with interferon-gamma, mRNAs for muscarinic M3 and M5 receptors could be detected in these cells, along with an increase in [Ca2+]i and chemotaxis induced by carbachol that could be blocked with 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) and pirenzepine. 4-diphenylacetoxy-1,1-dimethylpiperidinium 240-287 interferon gamma Homo sapiens 50-66 8851175-3 1996 Interestingly, when EoL-1 cells were treated with interferon-gamma, mRNAs for muscarinic M3 and M5 receptors could be detected in these cells, along with an increase in [Ca2+]i and chemotaxis induced by carbachol that could be blocked with 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) and pirenzepine. 4-diphenylacetoxy-1,1-dimethylpiperidinium 289-295 interferon gamma Homo sapiens 50-66 8851175-3 1996 Interestingly, when EoL-1 cells were treated with interferon-gamma, mRNAs for muscarinic M3 and M5 receptors could be detected in these cells, along with an increase in [Ca2+]i and chemotaxis induced by carbachol that could be blocked with 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) and pirenzepine. Pirenzepine 301-312 interferon gamma Homo sapiens 50-66 8568231-10 1996 However, the promotive effect of IL-7 on IFN-gamma and IL-4 gene expression could be blocked by genistein and cyclosporin A. Genistein 96-105 interferon gamma Homo sapiens 41-50 8568231-10 1996 However, the promotive effect of IL-7 on IFN-gamma and IL-4 gene expression could be blocked by genistein and cyclosporin A. Cyclosporine 110-123 interferon gamma Homo sapiens 41-50 8779919-7 1996 Adhesion of unstimulated human neutrophils to EAhy926 monolayers activated with TNF-alpha + IFN-gamma or LPS was increased in the presence of dexamethasone at low doses, whereas neutrophil adhesion to LPS- but not cytokine-stimulated endothelial cells was significantly reduced (P < 0.05) in the presence of a high dose of dexamethasone (1,000 nM). Dexamethasone 142-155 interferon gamma Homo sapiens 92-101 8568247-9 1996 Similarly, overexpression of XBR reduced induction of reporter gene activity driven from the DPA promoter in HeLa cells treated with IFN-gamma. dpa 93-96 interferon gamma Homo sapiens 133-142 8564096-9 1996 In prednisolone-treated patients there was also a reduction in the number of cells expressing mRNA for interleukin-4 (IL-4, p < 0.01), and interleukin-5 (IL-5, p < 0.03) and an increase in cells expressing mRNA for interferon-gamma (IFN-gamma) (p < 0.01). Prednisolone 3-15 interferon gamma Homo sapiens 221-237 8564096-9 1996 In prednisolone-treated patients there was also a reduction in the number of cells expressing mRNA for interleukin-4 (IL-4, p < 0.01), and interleukin-5 (IL-5, p < 0.03) and an increase in cells expressing mRNA for interferon-gamma (IFN-gamma) (p < 0.01). Prednisolone 3-15 interferon gamma Homo sapiens 239-248 8779914-9 1996 Serum-, carbachol-, and thapsigargin-stimulated [Ca2+]i elevations were reduced by 90, 60, and > 65%, respectively, in cells treated with IFN-gamma +/- TNF-alpha and 30, 45, and 45%, respectively, in cells treated with TNF-alpha. Carbachol 8-17 interferon gamma Homo sapiens 141-150 8779914-9 1996 Serum-, carbachol-, and thapsigargin-stimulated [Ca2+]i elevations were reduced by 90, 60, and > 65%, respectively, in cells treated with IFN-gamma +/- TNF-alpha and 30, 45, and 45%, respectively, in cells treated with TNF-alpha. Thapsigargin 24-36 interferon gamma Homo sapiens 141-150 11859380-13 1996 Here, we describe that IL-2 and IFN-gamma production are sensitive to PGE(2) and misoprostol, whereas IL-4 and IL-5 are unaffected. Prostaglandins E 70-73 interferon gamma Homo sapiens 32-41 8850311-0 1996 The macrolide antibiotic, roxithromycin suppresses IFN-gamma-mediated immunological functions of cultured normal human keratinocytes. Macrolides 4-13 interferon gamma Homo sapiens 51-60 8850311-0 1996 The macrolide antibiotic, roxithromycin suppresses IFN-gamma-mediated immunological functions of cultured normal human keratinocytes. Roxithromycin 26-39 interferon gamma Homo sapiens 51-60 8620520-14 1996 The agents 5-FU, cisplatin, IFNgamma, IFNalpha, and etoposide were the most effective in augmenting the cytotoxicity of ZME-gelonin against resistant cells. zme-gelonin 120-131 interferon gamma Homo sapiens 28-36 11859380-13 1996 Here, we describe that IL-2 and IFN-gamma production are sensitive to PGE(2) and misoprostol, whereas IL-4 and IL-5 are unaffected. Misoprostol 81-92 interferon gamma Homo sapiens 32-41 8641336-1 1996 Interleukin-10 (IL-10) inhibited the production of superoxide anion (02-) by both unactivated and interferon-gamma (IFN-gamma)-activated human monocytes. Superoxides 51-67 interferon gamma Homo sapiens 98-114 8641336-1 1996 Interleukin-10 (IL-10) inhibited the production of superoxide anion (02-) by both unactivated and interferon-gamma (IFN-gamma)-activated human monocytes. Superoxides 51-67 interferon gamma Homo sapiens 116-125 8655634-6 1996 However, IFN-gamma-induced Ia expression was significantly suppressed when the tyrosine kinase pathway was inhibited with herbimycin A and genestein. herbimycin 122-134 interferon gamma Homo sapiens 9-18 8603997-5 1996 Unlike murine macrophages, THP-1 cells produced little nitrite in response to interferon-gamma (IFN-gamma) and lipopolysaccharide, and a-MSH inhibited this production only slightly. Nitrites 55-62 interferon gamma Homo sapiens 78-94 8603997-5 1996 Unlike murine macrophages, THP-1 cells produced little nitrite in response to interferon-gamma (IFN-gamma) and lipopolysaccharide, and a-MSH inhibited this production only slightly. Nitrites 55-62 interferon gamma Homo sapiens 96-105 8632062-4 1996 To determine the immunoregulatory capacity of the phosphodiesterase inhibitor pentoxifylline (PTX), which is known to suppress the production of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), this drug was used in mitogen and antigen-stimulated lymphocyte cultures as well as in patients with multiple sclerosis. Pentoxifylline 78-92 interferon gamma Homo sapiens 189-205 8617321-3 1996 The effector mechanism responsible for this toxoplasmostatic effect was shown by us to be the IFN-gamma-mediated activation of indolamine 2,3-dioxygenase (IDO), resulting in the degradation of the essential amino acid tryptophan. essential amino acid tryptophan 197-228 interferon gamma Homo sapiens 94-103 8617323-4 1996 Conversely, substantial quantities of IFN-gamma were released in response to PPD (geometric mean 37.43 U/ml) compared to low BmA-stimulated IFN-gamma production in the same patients (geometric mean 5.02 U/ml). bma 125-128 interferon gamma Homo sapiens 140-149 8632062-4 1996 To determine the immunoregulatory capacity of the phosphodiesterase inhibitor pentoxifylline (PTX), which is known to suppress the production of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), this drug was used in mitogen and antigen-stimulated lymphocyte cultures as well as in patients with multiple sclerosis. Pentoxifylline 78-92 interferon gamma Homo sapiens 207-216 8632062-4 1996 To determine the immunoregulatory capacity of the phosphodiesterase inhibitor pentoxifylline (PTX), which is known to suppress the production of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), this drug was used in mitogen and antigen-stimulated lymphocyte cultures as well as in patients with multiple sclerosis. Pentoxifylline 94-97 interferon gamma Homo sapiens 189-205 8632062-4 1996 To determine the immunoregulatory capacity of the phosphodiesterase inhibitor pentoxifylline (PTX), which is known to suppress the production of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), this drug was used in mitogen and antigen-stimulated lymphocyte cultures as well as in patients with multiple sclerosis. Pentoxifylline 94-97 interferon gamma Homo sapiens 207-216 8669050-3 1996 In this study the effect von N-acetylcysteine (NAC) on the release of interleukin-1 alpha and beta (IL-1), interleukin-2 (IL-2), interferon-gamma (IFN-gamma) and tumornecrosisfactor-alpha (TNF-alpha) was assessed in an in vitro assay. Acetylcysteine 47-50 interferon gamma Homo sapiens 129-145 8742370-5 1996 Human PBMC stimulated in vitro with IL-2 and murabutide showed synergistic levels of induced mRNA accumulation and protein secretion for IFN-gamma, IL-12, and colony-stimulating factors (CSFs). murabutide 45-55 interferon gamma Homo sapiens 137-146 8745411-5 1996 Production of recombinant IFN-gamma in the mammalian expression systems yielded polypeptides C-terminally truncated at dibasic amino acid sites. Amino Acids, Diamino 119-137 interferon gamma Homo sapiens 26-35 8745411-6 1996 Mammalian cell derived IFN-gamma molecules displayed oligosaccharides with monosaccharide compositions equivalent to complex, sialylated, or high-mannose type N-glycans. Oligosaccharides 53-69 interferon gamma Homo sapiens 23-32 8745411-6 1996 Mammalian cell derived IFN-gamma molecules displayed oligosaccharides with monosaccharide compositions equivalent to complex, sialylated, or high-mannose type N-glycans. Monosaccharides 75-89 interferon gamma Homo sapiens 23-32 8745411-6 1996 Mammalian cell derived IFN-gamma molecules displayed oligosaccharides with monosaccharide compositions equivalent to complex, sialylated, or high-mannose type N-glycans. Mannose 146-153 interferon gamma Homo sapiens 23-32 8745411-6 1996 Mammalian cell derived IFN-gamma molecules displayed oligosaccharides with monosaccharide compositions equivalent to complex, sialylated, or high-mannose type N-glycans. n-glycans 159-168 interferon gamma Homo sapiens 23-32 8745411-7 1996 In contrast, IFN-gamma derived from baculovirus-infected Sf9 insect cells was truncated further toward the C-terminus and was associated with neutral (nonsialylated) N-glycans. n-glycans 166-175 interferon gamma Homo sapiens 13-22 8669050-3 1996 In this study the effect von N-acetylcysteine (NAC) on the release of interleukin-1 alpha and beta (IL-1), interleukin-2 (IL-2), interferon-gamma (IFN-gamma) and tumornecrosisfactor-alpha (TNF-alpha) was assessed in an in vitro assay. Acetylcysteine 47-50 interferon gamma Homo sapiens 147-156 8560558-4 1996 Cells from both groups were also stimulated with OKT3 to determine the effect of CsA on the induction of IFN-gamma synthesis. Cyclosporine 81-84 interferon gamma Homo sapiens 105-114 9244168-2 1996 Lipopolysaccharide impaired oxygen consumption in a dose-dependent manner which was shown to be mediated by mitochondrial dysfunction and could be augmented by pretreatment of the cells with interferon-gamma. Oxygen 28-34 interferon gamma Homo sapiens 191-207 8906257-6 1996 Interferon-gamma also caused a dramatic dose-dependent increase in indoleamine 2,3-dioxygenase mRNA, with consequent depletion of tryptophan and accumulation of kynurenine in the culture media. Tryptophan 130-140 interferon gamma Homo sapiens 0-16 8906257-6 1996 Interferon-gamma also caused a dramatic dose-dependent increase in indoleamine 2,3-dioxygenase mRNA, with consequent depletion of tryptophan and accumulation of kynurenine in the culture media. Kynurenine 161-171 interferon gamma Homo sapiens 0-16 8906257-8 1996 Supplementation with tryptophan completely overcame the inhibitory effects of interferon-gamma on MMP mRNA expression and metalloproteinase secretion into the media. Tryptophan 21-31 interferon gamma Homo sapiens 78-94 8906257-10 1996 These results indicate that oxidative tryptophan metabolism mediates the effects of interferon-gamma on MMP gene expression in human fibroblasts. Tryptophan 38-48 interferon gamma Homo sapiens 84-100 8906259-0 1996 Tryptophan starvation is involved in human interferon-gamma mediated apoptosis. Tryptophan 0-10 interferon gamma Homo sapiens 43-59 8982439-2 1996 Although glycyrrhizin did not induce nitric oxide from resting macrophages, it enhanced the production of nitric oxide from IFN-gamma activated-macrophages or RAW cells. Glycyrrhizic Acid 9-21 interferon gamma Homo sapiens 124-133 8982439-2 1996 Although glycyrrhizin did not induce nitric oxide from resting macrophages, it enhanced the production of nitric oxide from IFN-gamma activated-macrophages or RAW cells. Nitric Oxide 106-118 interferon gamma Homo sapiens 124-133 8982439-4 1996 Further, glycyrrhizin enhanced tumor cell killing by macrophages activated with IFN-gamma. Glycyrrhizic Acid 9-21 interferon gamma Homo sapiens 80-89 8560558-7 1996 Likewise, for CsA inhibition of IFN-gamma induction, the IC50 was 18 micrograms/L for PBL in CM compared with 690 micrograms/L for PBL in WB (P < or = 0.005). Cyclosporine 14-17 interferon gamma Homo sapiens 32-41 8615638-2 1996 Recently we reported that interferon-gamma (IFN-gamma) modulates the action of retinoic acid (RA): IFN-gamma increased expression of retinoic acid receptor-gamma (RAR-gamma) and suppressed the increase of retinoic acid binding protein type II (CRABP-II) expression. Tretinoin 79-92 interferon gamma Homo sapiens 26-42 8824667-4 1996 Leukocytospermia is associated with reduced in vitro fertilization rate, and experimentally-measured sperm functions (e.g., motility) are inhibited by high concentrations of certain WBC products (e.g., reactive oxygen species and interferon-gamma). Reactive Oxygen Species 202-225 interferon gamma Homo sapiens 230-246 8915510-8 1996 IFN-alpha stimulated preparations also expressed IFN-gamma, possibly due to the presence of MAMC, which comprised 2-9% of the total cell population. mamc 92-96 interferon gamma Homo sapiens 49-58 8915510-9 1996 These data indicated that HuIFN-alpha upregulates MHC class II expression by human BEC, possibly by enhancing IFN-gamma production by MAMC present in the culture preparations. mamc 134-138 interferon gamma Homo sapiens 110-119 8615638-2 1996 Recently we reported that interferon-gamma (IFN-gamma) modulates the action of retinoic acid (RA): IFN-gamma increased expression of retinoic acid receptor-gamma (RAR-gamma) and suppressed the increase of retinoic acid binding protein type II (CRABP-II) expression. Tretinoin 79-92 interferon gamma Homo sapiens 44-53 8615638-2 1996 Recently we reported that interferon-gamma (IFN-gamma) modulates the action of retinoic acid (RA): IFN-gamma increased expression of retinoic acid receptor-gamma (RAR-gamma) and suppressed the increase of retinoic acid binding protein type II (CRABP-II) expression. Tretinoin 79-92 interferon gamma Homo sapiens 99-108 8615638-2 1996 Recently we reported that interferon-gamma (IFN-gamma) modulates the action of retinoic acid (RA): IFN-gamma increased expression of retinoic acid receptor-gamma (RAR-gamma) and suppressed the increase of retinoic acid binding protein type II (CRABP-II) expression. Tretinoin 94-96 interferon gamma Homo sapiens 26-42 8615638-2 1996 Recently we reported that interferon-gamma (IFN-gamma) modulates the action of retinoic acid (RA): IFN-gamma increased expression of retinoic acid receptor-gamma (RAR-gamma) and suppressed the increase of retinoic acid binding protein type II (CRABP-II) expression. Tretinoin 94-96 interferon gamma Homo sapiens 44-53 8615638-2 1996 Recently we reported that interferon-gamma (IFN-gamma) modulates the action of retinoic acid (RA): IFN-gamma increased expression of retinoic acid receptor-gamma (RAR-gamma) and suppressed the increase of retinoic acid binding protein type II (CRABP-II) expression. Tretinoin 94-96 interferon gamma Homo sapiens 99-108 8585942-2 1996 A transcription factor designated differentiation-induced factor (DIF), activated by treatment of myeloid cells with the differentiating agents interferon-gamma (IFN-gamma), granulocyte-macrophage colony-stimulating factor (GM-CSF), colony-stimulating factor-1 (CSF-1) or during phorbol ester-induced differentiation, was characterized as a 112kDa protein related to, but not identical with known isoforms of STAT 5. Phorbol Esters 279-292 interferon gamma Homo sapiens 144-160 8995502-2 1996 In the presence of AML blasts, R-verapamil inhibited interleukin 4 (IL4) and interferon-gamma (IFNgamma) release from polyclonal T-cell lines activated with the T-cell mitogen phytohemagglutinin (PHA). Verapamil 31-42 interferon gamma Homo sapiens 77-93 8995502-2 1996 In the presence of AML blasts, R-verapamil inhibited interleukin 4 (IL4) and interferon-gamma (IFNgamma) release from polyclonal T-cell lines activated with the T-cell mitogen phytohemagglutinin (PHA). Verapamil 31-42 interferon gamma Homo sapiens 95-103 8995502-3 1996 R-verapamil also inhibited both the proliferation and the release of IFNgamma and IL10 by normal T-cells stimulated with allogeneic peripheral blood mononuclear cells derived from AML patients. Verapamil 0-11 interferon gamma Homo sapiens 69-77 8585942-2 1996 A transcription factor designated differentiation-induced factor (DIF), activated by treatment of myeloid cells with the differentiating agents interferon-gamma (IFN-gamma), granulocyte-macrophage colony-stimulating factor (GM-CSF), colony-stimulating factor-1 (CSF-1) or during phorbol ester-induced differentiation, was characterized as a 112kDa protein related to, but not identical with known isoforms of STAT 5. Phorbol Esters 279-292 interferon gamma Homo sapiens 162-171 8886794-1 1996 Neopterin, 6-D-erythro-1",2",3"-trihydroxypropyl-pterin, and its dihydroform, 7,8-dihydro-neopterin, are synthesized by human monocytes/macrophages upon stimulation by interferon-gamma. Neopterin 0-9 interferon gamma Homo sapiens 168-184 8886794-1 1996 Neopterin, 6-D-erythro-1",2",3"-trihydroxypropyl-pterin, and its dihydroform, 7,8-dihydro-neopterin, are synthesized by human monocytes/macrophages upon stimulation by interferon-gamma. 6-d-erythro-1",2",3"-trihydroxypropyl-pterin 11-55 interferon gamma Homo sapiens 168-184 8886794-1 1996 Neopterin, 6-D-erythro-1",2",3"-trihydroxypropyl-pterin, and its dihydroform, 7,8-dihydro-neopterin, are synthesized by human monocytes/macrophages upon stimulation by interferon-gamma. 7,8-dihydroneopterin 78-99 interferon gamma Homo sapiens 168-184 27406429-4 1996 In various diseases concentrations of sTNF-Rs correlate strongly with levels of neopterin, large amounts of which being released from human monocytes/macrophages upon stimulation with interferon-gamma. Neopterin 80-89 interferon gamma Homo sapiens 184-200 8566837-2 1996 Salicylates have been shown to reduce IFN gamma induced HLA-DR expression. Salicylates 0-11 interferon gamma Homo sapiens 38-47 8566837-3 1996 The effect of 5-aminosalicylic acid (5-ASA) on IFN gamma induced changes in transepithelial resistance and permeability was investigated in HT29 clone 19A and Caco 2 monolayers. Mesalamine 14-35 interferon gamma Homo sapiens 47-56 8566837-3 1996 The effect of 5-aminosalicylic acid (5-ASA) on IFN gamma induced changes in transepithelial resistance and permeability was investigated in HT29 clone 19A and Caco 2 monolayers. Mesalamine 37-42 interferon gamma Homo sapiens 47-56 8566837-6 1996 HT29:19A monolayers incubated with both IFN gamma and 5-ASA showed lower HLA-DR expression compared with monolayers incubated with IFN gamma alone. Mesalamine 54-59 interferon gamma Homo sapiens 131-140 8566837-7 1996 Electrical resistance and 14C-mannitol flux across HT29:19A monolayers were significantly changed by IFN gamma. 14c-mannitol 26-38 interferon gamma Homo sapiens 101-110 8566837-8 1996 Addition of both IFN gamma and 5-ASA to the basolateral surface of the monolayers significantly reduced paracellular permeability compared with addition of IFN gamma alone. Mesalamine 31-36 interferon gamma Homo sapiens 156-165 8566837-9 1996 These data show that IFN gamma is able to induce HLA-DR expression and to impair the barrier function of HT29:19A monolayers, and that 5-ASA reduces IFN gamma induced HLA-DR expression and inhibits the effects of IFN gamma on epithelial barrier function. Mesalamine 135-140 interferon gamma Homo sapiens 149-158 8566837-9 1996 These data show that IFN gamma is able to induce HLA-DR expression and to impair the barrier function of HT29:19A monolayers, and that 5-ASA reduces IFN gamma induced HLA-DR expression and inhibits the effects of IFN gamma on epithelial barrier function. Mesalamine 135-140 interferon gamma Homo sapiens 149-158 8568141-7 1996 Increased AD monocyte production of inflammatory factors (e.g., PGE2) and cytokines appears to increase IL-4 production by Th2 while suppressing IFN-gamma production by Th1. Dinoprostone 64-68 interferon gamma Homo sapiens 145-154 9061375-0 1996 7,8-Dihydroneopterin upregulates interferon-gamma promoter in T cells. 7,8-dihydroneopterin 0-20 interferon gamma Homo sapiens 33-49 9061375-1 1996 Activated cell-mediated immunity is accompanied by elevated concentrations of interferon-gamma leading to the secretion of neopterin-derivatives which are known as sensitive immune activation markers in clinical laboratory diagnosis. Neopterin 123-132 interferon gamma Homo sapiens 78-94 9061375-3 1996 We report here that 7,8-dihydroneopterin and hydrogen peroxide upregulate the production of interferon-gamma, thereby establishing an autocrine feed-back loop. 7,8-dihydroneopterin 20-40 interferon gamma Homo sapiens 92-108 9061375-3 1996 We report here that 7,8-dihydroneopterin and hydrogen peroxide upregulate the production of interferon-gamma, thereby establishing an autocrine feed-back loop. Hydrogen Peroxide 45-62 interferon gamma Homo sapiens 92-108 8926285-7 1996 Phorbol myristate acetate (PMA) and ionophore stimulated TNF-alpha and IFN-gamma secretion in both the binder and the killer subsets, though IFN-gamma secretion was more pronounced in the binder subset. Tetradecanoylphorbol Acetate 0-25 interferon gamma Homo sapiens 71-80 8926285-7 1996 Phorbol myristate acetate (PMA) and ionophore stimulated TNF-alpha and IFN-gamma secretion in both the binder and the killer subsets, though IFN-gamma secretion was more pronounced in the binder subset. Tetradecanoylphorbol Acetate 0-25 interferon gamma Homo sapiens 141-150 8926285-7 1996 Phorbol myristate acetate (PMA) and ionophore stimulated TNF-alpha and IFN-gamma secretion in both the binder and the killer subsets, though IFN-gamma secretion was more pronounced in the binder subset. Tetradecanoylphorbol Acetate 27-30 interferon gamma Homo sapiens 71-80 8640446-0 1996 Potentiation by thyroxine of interferon-gamma-induced HLA-DR expression is protein kinase A- and C-dependent. Thyroxine 16-25 interferon gamma Homo sapiens 29-45 8640446-1 1996 L-Thyroxine (T4) and 3,3",5-L-triiodothyronine (T3) potentiate the antiviral state induced by interferon-gamma(IFN-gamma) in homologous cells by a mechanism that is dependent upon calcium/phospholipid-dependent protein kinase (PKC). Thyroxine 0-11 interferon gamma Homo sapiens 94-120 8640446-1 1996 L-Thyroxine (T4) and 3,3",5-L-triiodothyronine (T3) potentiate the antiviral state induced by interferon-gamma(IFN-gamma) in homologous cells by a mechanism that is dependent upon calcium/phospholipid-dependent protein kinase (PKC). Triiodothyronine, Reverse 21-46 interferon gamma Homo sapiens 94-120 8640446-1 1996 L-Thyroxine (T4) and 3,3",5-L-triiodothyronine (T3) potentiate the antiviral state induced by interferon-gamma(IFN-gamma) in homologous cells by a mechanism that is dependent upon calcium/phospholipid-dependent protein kinase (PKC). Triiodothyronine 48-50 interferon gamma Homo sapiens 94-120 8640446-3 1996 In the present studies of HLA-DR expression, the PKC inhibitor staurosporine (0.1-1 nM) enhanced the expression of HLA-DR when the inhibitor was added simultaneously with IFN-gamma, 100 IU/ml. Staurosporine 63-76 interferon gamma Homo sapiens 171-180 8640446-4 1996 In the presence of IFN-gamma and 10(-7) M T4, the same concentrations of staurosporine inhibited potentiation of HLA-DR expression by thyroid hormone. Staurosporine 73-86 interferon gamma Homo sapiens 19-28 8640446-5 1996 A more specific PKC inhibitor, CGP41251 (0.5-5 nM), similarly enhanced HLA-DR expression in the presence of IFN-gamma but inhibited thyroid hormone potentiation of antigen expression. midostaurin 31-39 interferon gamma Homo sapiens 108-117 8640446-7 1996 A phospholipase C inhibitor, U73122 (1-1000 nM), did not alter the potentiating ability of T4, although it inhibited in a concentration-dependent manner the expression of HLA-DR induced by IFN-gamma. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 29-35 interferon gamma Homo sapiens 189-198 8523577-7 1996 This IFN-gamma response element in the CAEV LTR differs from the element required for the response to phorbol esters. Phorbol Esters 102-116 interferon gamma Homo sapiens 5-14 8624460-5 1996 In this review, a novel posttranscriptional regulation of ICAM-1 gene expression by two inflammatory mediators, interferon-gamma and phorbol myristate acetate, and the possible role of the serine/threonine phosphorylation pathway in the cycloheximide-induced ICAM-1 message stabilization are discussed in light of our current understanding of ICAM-1 gene regulation during an inflammatory response. Cycloheximide 237-250 interferon gamma Homo sapiens 112-128 8805102-5 1996 Prostaglandin E2 depressed the production of IL-1 alpha, while it up-regulated the production of IL-6, TNF-alpha, and IFN-gamma. Dinoprostone 0-16 interferon gamma Homo sapiens 118-127 8579853-11 1996 It has been reported that TNF-alpha enhances the effect of IFN-gamma for neopterin release by macrophages in vitro and that dexamethasone has the same effect on IFN-gamma as TNF-alpha. Neopterin 73-82 interferon gamma Homo sapiens 59-68 8579853-11 1996 It has been reported that TNF-alpha enhances the effect of IFN-gamma for neopterin release by macrophages in vitro and that dexamethasone has the same effect on IFN-gamma as TNF-alpha. Dexamethasone 124-137 interferon gamma Homo sapiens 161-170 8579853-12 1996 The present study suggests that elevation of CSF neopterin in bacterial meningitis results from monocytes/macrophages costimulated with IFN-gamma, TNF-alpha and dexamethasone used in treatment. Neopterin 49-58 interferon gamma Homo sapiens 136-145 8825401-5 1996 In the absence of IL-12, only adult BMC spontaneously produced low levels of IFN-gamma. bmc 36-39 interferon gamma Homo sapiens 77-86 8825401-6 1996 After IL-12 treatment, induction of IFN-gamma expression was detected as early as 4 h in both cord and adult BMC. bmc 109-112 interferon gamma Homo sapiens 36-45 8825401-8 1996 In contrast, upon phorbol ester and ionomycin treatment, adult BMC produced more IFN-gamma mRNA than cord BMC. Phorbol Esters 18-31 interferon gamma Homo sapiens 81-90 8825401-8 1996 In contrast, upon phorbol ester and ionomycin treatment, adult BMC produced more IFN-gamma mRNA than cord BMC. Ionomycin 36-45 interferon gamma Homo sapiens 81-90 8825401-8 1996 In contrast, upon phorbol ester and ionomycin treatment, adult BMC produced more IFN-gamma mRNA than cord BMC. bmc 63-66 interferon gamma Homo sapiens 81-90 8545886-3 1995 Transcripts for the Th1-like cytokines IL-2 and IFN-gamma were detected in 53.3% and 46.7% of CR grafts, while they were detected in only 16% and 0% of stable grafts, respectively. Chromium 94-96 interferon gamma Homo sapiens 48-57 12237688-2 1996 So we suppose that mutants 25/97Cys-IFN-gamma and PEG-25/97-Cys-IFN-gamma have the same bioactivity as native. Polyethylene Glycols 50-53 interferon gamma Homo sapiens 64-73 12237688-2 1996 So we suppose that mutants 25/97Cys-IFN-gamma and PEG-25/97-Cys-IFN-gamma have the same bioactivity as native. Cysteine 32-35 interferon gamma Homo sapiens 36-45 7499872-5 1995 Inhibition was due to nitric oxide (NO), which was only produced if LPS was given simultaneously with IFN-gamma. Nitric Oxide 22-34 interferon gamma Homo sapiens 102-111 18623533-0 1995 N-glycans of recombinant human interferon-gamma change during batch culture of chinese hamster ovary cells. n-glycans 0-9 interferon gamma Homo sapiens 31-47 7492276-12 1995 In contrast, methylene blue, a guanylate cyclase inhibitor, inhibited LPS-, LPS+IFN-gamma-, and sodium nitroprusside-induced TNF-alpha production and cGMP increase; hemoglobin, which traps CO, had a similar effect. Methylene Blue 13-27 interferon gamma Homo sapiens 80-89 18623533-2 1995 In addition to cell growth, metabolite, and productivity data, a detailed analysis of the carbohydrate structures attached to each glycosylation site of IFN-gamma was achieved using matrix-assisted laser desorption mass spectrometry (MALDI-MS) in combination with exoglycosidase array sequencing. Carbohydrates 90-102 interferon gamma Homo sapiens 153-162 7492276-12 1995 In contrast, methylene blue, a guanylate cyclase inhibitor, inhibited LPS-, LPS+IFN-gamma-, and sodium nitroprusside-induced TNF-alpha production and cGMP increase; hemoglobin, which traps CO, had a similar effect. Cyclic GMP 150-154 interferon gamma Homo sapiens 80-89 8680718-11 1995 8 The addition of TNF-alpha produced a significant (P < 0.001) 3 fold increase of IL-1 alpha/IFN-gamma-induced nitrite generation. Nitrites 114-121 interferon gamma Homo sapiens 96-105 8680718-9 1995 6 Studies with IL-1 alpha/IFN-gamma combination demonstrated a time dependent expression of iNOS mRNA, first observed at 6 h, peaked at 24 h and was undetectable by 72 h. IL-1 alpha (0.3-10 ng ml-1) and IFN-gamma (10-300 u ml-1) in combination induced a concentration-dependent expression of iNOS mRNA at 24 h. 7 Pretreatment with cycloheximide before IL-1 alpha/IFN-gamma stimulation reduced nitrite levels to basal values. Nitrites 393-400 interferon gamma Homo sapiens 26-35 8680718-7 1995 The combination of IL-1 alpha/IFN-gamma produced a highly significant (P < 0.001) 4 fold increase in nitrite production at 48 h, compared to basal values, while no other pair of cytokines was effective. Nitrites 104-111 interferon gamma Homo sapiens 30-39 8680718-8 1995 5 Time course studies with IL-1 alpha/IFN-gamma combination revealed significant (P < 0.001) increases in nitrite at 24 h (153 +/- 7), 48 h (306 +/- 24), and 72 h (384 +/- 15) compared to basal values of 50 +/- 4, 75 +/- 8, and 103 +/- 8 nM per 10(6) cells respectively. Nitrites 109-116 interferon gamma Homo sapiens 38-47 8680718-9 1995 6 Studies with IL-1 alpha/IFN-gamma combination demonstrated a time dependent expression of iNOS mRNA, first observed at 6 h, peaked at 24 h and was undetectable by 72 h. IL-1 alpha (0.3-10 ng ml-1) and IFN-gamma (10-300 u ml-1) in combination induced a concentration-dependent expression of iNOS mRNA at 24 h. 7 Pretreatment with cycloheximide before IL-1 alpha/IFN-gamma stimulation reduced nitrite levels to basal values. Cycloheximide 331-344 interferon gamma Homo sapiens 26-35 8680718-10 1995 These data suggest that the IL-1 alpha/IFN-gamma-induced nitrite production by HT-29 cells is dependent on de novo protein synthesis, probably the iNOS enzyme. Nitrites 57-64 interferon gamma Homo sapiens 39-48 8680718-13 1995 These findings suggest that the up-regulation by TNF-alpha of IL-1 alpha/IFN-gamma-induced nitrite generation is at the post-transcriptional level. Nitrites 91-98 interferon gamma Homo sapiens 73-82 7583437-3 1995 Pentoxifylline inhibited cytotoxicity of CTLs and suppressed interferon-gamma, tumor necrosis factor-alpha, and granulocyte-macrophage colony-stimulating factor release by these cells at the transcription level. Pentoxifylline 0-14 interferon gamma Homo sapiens 61-106 8536384-3 1995 The T cells, when activated via the T cell receptor (TCR)/CD3 complex, were suppressed functionally by minocycline, resulting in a dose-dependent inhibition of T cell proliferation and reduction in production of IL-2, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha). Minocycline 103-114 interferon gamma Homo sapiens 218-234 8536384-3 1995 The T cells, when activated via the T cell receptor (TCR)/CD3 complex, were suppressed functionally by minocycline, resulting in a dose-dependent inhibition of T cell proliferation and reduction in production of IL-2, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha). Minocycline 103-114 interferon gamma Homo sapiens 236-245 8567031-5 1995 The ability of LPS, IFN-gamma, TNF-alpha or PAF to maintain the high superoxide response was blocked by addition of inhibitors of serine proteases, either 4-(2-aminoethyl)-benzenesulphonyl fluoride (AEBSF) or 3,4-dichloroisocoumarin. Superoxides 69-79 interferon gamma Homo sapiens 20-29 8567031-5 1995 The ability of LPS, IFN-gamma, TNF-alpha or PAF to maintain the high superoxide response was blocked by addition of inhibitors of serine proteases, either 4-(2-aminoethyl)-benzenesulphonyl fluoride (AEBSF) or 3,4-dichloroisocoumarin. 4-(2-aminoethyl)-benzenesulphonyl fluoride 155-197 interferon gamma Homo sapiens 20-29 8567031-5 1995 The ability of LPS, IFN-gamma, TNF-alpha or PAF to maintain the high superoxide response was blocked by addition of inhibitors of serine proteases, either 4-(2-aminoethyl)-benzenesulphonyl fluoride (AEBSF) or 3,4-dichloroisocoumarin. 4-(2-aminoethyl)benzenesulfonylfluoride 199-204 interferon gamma Homo sapiens 20-29 8567031-5 1995 The ability of LPS, IFN-gamma, TNF-alpha or PAF to maintain the high superoxide response was blocked by addition of inhibitors of serine proteases, either 4-(2-aminoethyl)-benzenesulphonyl fluoride (AEBSF) or 3,4-dichloroisocoumarin. 3,4-dichloroisocoumarin 209-232 interferon gamma Homo sapiens 20-29 8567031-11 1995 We conclude that activity of a monocyte serine protease is required to maintain the high superoxide response in monocytes primed with LPS, IFN-gamma, TNF-alpha, or PAF. Superoxides 89-99 interferon gamma Homo sapiens 139-148 8543752-4 1995 The release of IL-4 and IFN-gamma from peripheral blood mononuclear cells stimulated by polyclonal agents (calcium ionophore A23187 and phorbol myristate acetate) was measured by ELISA. Calcium 107-114 interferon gamma Homo sapiens 24-33 8595930-3 1995 IFN-gamma treatment enhanced O2- production of fMLP or PMA-stimulated U937 cells. Superoxides 29-31 interferon gamma Homo sapiens 0-9 7490476-3 1995 After IFN-gamma treatment in the presence of anti-Fas monoclonal antibody, apoptosis was induced, as detected by the formation of nucleosome-sized fragments of DNA and morphologically by apoptotic cells with round homogeneous nuclear beads detected by acridine orange staining. Acridine Orange 252-267 interferon gamma Homo sapiens 6-15 8964650-6 1995 Similarly, PTX and CsA synergistically inhibited the release of IL-2, IFN-gamma and, to a lesser degree, TNF-alpha. Pentoxifylline 11-14 interferon gamma Homo sapiens 70-79 8964650-6 1995 Similarly, PTX and CsA synergistically inhibited the release of IL-2, IFN-gamma and, to a lesser degree, TNF-alpha. Cyclosporine 19-22 interferon gamma Homo sapiens 70-79 7499964-8 1995 The formation of nitrites by interferon-gamma-activated macrophages was inhibited by TauCl in a dose-dependent manner. Nitrites 17-25 interferon gamma Homo sapiens 29-45 7499964-8 1995 The formation of nitrites by interferon-gamma-activated macrophages was inhibited by TauCl in a dose-dependent manner. N-chlorotaurine 85-90 interferon gamma Homo sapiens 29-45 7490476-5 1995 The IFN-gamma- and anti-Fas antibody-dependent apoptotis was observed by 3 h, and the maximal response was observed by 12 h. The induction of apoptosis was significantly augmented by treatment with 10 ng/ml 12-o-tetradecanoyl-phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 207-244 interferon gamma Homo sapiens 4-13 7594536-8 1995 Thus, CD45 may regulate p56lck kinase, which initiates the cascade of intracellular tyrosine phosphorylation events that lead to IFN-gamma transcription and secretion in NK 3.3 cells. Tyrosine 84-92 interferon gamma Homo sapiens 129-138 7490476-5 1995 The IFN-gamma- and anti-Fas antibody-dependent apoptotis was observed by 3 h, and the maximal response was observed by 12 h. The induction of apoptosis was significantly augmented by treatment with 10 ng/ml 12-o-tetradecanoyl-phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 246-249 interferon gamma Homo sapiens 4-13 7490476-7 1995 Other protein kinase C activators (1-oleoyl-2-acetylglycerol and mezerein) also stimulated IFN-gamma-dependent apoptosis, whereas 4-o-methyl phorbol myristate acetate, a very weak protein kinase C activator, had only a slight effect. 1-oleoyl-2-acetylglycerol 35-60 interferon gamma Homo sapiens 91-100 7490476-7 1995 Other protein kinase C activators (1-oleoyl-2-acetylglycerol and mezerein) also stimulated IFN-gamma-dependent apoptosis, whereas 4-o-methyl phorbol myristate acetate, a very weak protein kinase C activator, had only a slight effect. mezerein 65-73 interferon gamma Homo sapiens 91-100 7490512-1 1995 Induction of indoleamine 2,3-dioxygenase (IDO), an enzyme expressed by mononuclear phagocytes and some fibroblast cell lines in response to interferon-gamma, leads to enhanced degradation of tryptophan to kynurenine. Tryptophan 191-201 interferon gamma Homo sapiens 140-156 7490512-1 1995 Induction of indoleamine 2,3-dioxygenase (IDO), an enzyme expressed by mononuclear phagocytes and some fibroblast cell lines in response to interferon-gamma, leads to enhanced degradation of tryptophan to kynurenine. Kynurenine 205-215 interferon gamma Homo sapiens 140-156 8963391-0 1995 Effects of chenodeoxycholic and ursodeoxycholic acids on interferon-gamma production by peripheral blood mononuclear cells from patients with primary biliary cirrhosis. chenodeoxycholic 11-27 interferon gamma Homo sapiens 57-73 8963391-0 1995 Effects of chenodeoxycholic and ursodeoxycholic acids on interferon-gamma production by peripheral blood mononuclear cells from patients with primary biliary cirrhosis. Ursodeoxycholic Acid 32-53 interferon gamma Homo sapiens 57-73 8963391-7 1995 The effect of UDCA and chenodeoxycholic acid (CDCA) on IFN-gamma production in PBMCs from 12 normal subjects was also analyzed. Chenodeoxycholic Acid 23-44 interferon gamma Homo sapiens 55-64 8963391-7 1995 The effect of UDCA and chenodeoxycholic acid (CDCA) on IFN-gamma production in PBMCs from 12 normal subjects was also analyzed. Chenodeoxycholic Acid 46-50 interferon gamma Homo sapiens 55-64 8963391-8 1995 IFN-gamma was produced dose-dependently according to concentrations of CDCA ranging from 0.1 to 10 microM, but the increase in production was markedly suppressed by the addition of UDCA. Chenodeoxycholic Acid 71-75 interferon gamma Homo sapiens 0-9 8963391-9 1995 We conclude that low doses of CDCA enhance IFN-gamma production and may therefore lead to the aberrant hepatic expression of MHC molecules, and that the increase in IFN-gamma production is suppressed by UDCA. Chenodeoxycholic Acid 30-34 interferon gamma Homo sapiens 43-52 8752503-2 1995 All epithelial cells exhibited constitutive NOS activity that was calcium-dependent, and inducible, lesser calcium-dependent activity in the presence of interferon-gamma, interleukin-1 beta, tumor necrosis factor-alpha, and lipopolysaccharide. Calcium 107-114 interferon gamma Homo sapiens 153-169 8848188-4 1995 Prednisone treatment during the first month on the drug prevented the interferon-gamma-secreting cell surge. Prednisone 0-10 interferon gamma Homo sapiens 70-86 8749856-4 1995 Isomorphous crystals have been obtained with complex containing selenomethionine and cysteine mutants of IFN-gamma, which may facilitate the ongoing X-ray structure determination. Cysteine 85-93 interferon gamma Homo sapiens 105-114 7594459-0 1995 Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5. Dinoprostone 0-16 interferon gamma Homo sapiens 93-102 8746783-5 1995 After incubation with both predesquamin and IFN-gamma (but not either alone), the mobility of plasmid DNA in a gel shows retardation specific for guanine residues. Guanine 146-153 interferon gamma Homo sapiens 44-53 7594459-3 1995 These activated T cells produced IL-2, IL-4, IL-5, and IFN-gamma upon stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 87-90 interferon gamma Homo sapiens 55-64 8857113-5 1995 Rox at its pharmacologically attainable concentrations suppressed the IFN-gamma production of CD45RA (-) T cells stimulated with immobilized anti-CD3, but not that of unfractionated T cells. Roxithromycin 0-3 interferon gamma Homo sapiens 70-79 7594459-3 1995 These activated T cells produced IL-2, IL-4, IL-5, and IFN-gamma upon stimulation with PMA and ionomycin. Ionomycin 95-104 interferon gamma Homo sapiens 55-64 7594459-4 1995 PGE2 added at priming of naive T cells inhibited the production of IL-2 and IFN-gamma, but not of IL-4 and IL-5, in a dose-dependent manner. Dinoprostone 0-4 interferon gamma Homo sapiens 76-85 7594459-8 1995 PGE2 must exist at an early stage of T cell activation to inhibit priming for IL-2 and IFN-gamma production. Dinoprostone 0-4 interferon gamma Homo sapiens 87-96 7594459-9 1995 PGE2 also showed this effect, even in the presence of exogenous IFN-gamma, at the primary stimulation. Dinoprostone 0-4 interferon gamma Homo sapiens 64-73 7594459-10 1995 These results indicate that PGE2 inhibits the acquisition of the ability to produce IL-2 and IFN-gamma by acting directly on naive T cells. Dinoprostone 28-32 interferon gamma Homo sapiens 93-102 7579440-9 1995 When CD34+ cells were treated with IFN-gamma and TNF-alpha, IRF-1 antisense oligodeoxynucleotide (ODN) partially reversed the suppressive effects on CD34+ cell-derived colony formation by IFN-gamma but not those by TNF-alpha. Oligodeoxyribonucleotides 76-96 interferon gamma Homo sapiens 35-44 8857113-8 1995 These results suggest that Rox may preferentially suppress the IFN-gamma production of memory T cells, but not that of naive T cells. Roxithromycin 27-30 interferon gamma Homo sapiens 63-72 7579440-9 1995 When CD34+ cells were treated with IFN-gamma and TNF-alpha, IRF-1 antisense oligodeoxynucleotide (ODN) partially reversed the suppressive effects on CD34+ cell-derived colony formation by IFN-gamma but not those by TNF-alpha. Oligodeoxyribonucleotides 76-96 interferon gamma Homo sapiens 188-197 7579440-9 1995 When CD34+ cells were treated with IFN-gamma and TNF-alpha, IRF-1 antisense oligodeoxynucleotide (ODN) partially reversed the suppressive effects on CD34+ cell-derived colony formation by IFN-gamma but not those by TNF-alpha. Oligodeoxyribonucleotides 98-101 interferon gamma Homo sapiens 35-44 7588238-0 1995 Interferon-gamma increases intracellular calcium and inositol phosphates in primary human thyroid cell culture. Calcium 41-48 interferon gamma Homo sapiens 0-16 7579440-9 1995 When CD34+ cells were treated with IFN-gamma and TNF-alpha, IRF-1 antisense oligodeoxynucleotide (ODN) partially reversed the suppressive effects on CD34+ cell-derived colony formation by IFN-gamma but not those by TNF-alpha. Oligodeoxyribonucleotides 98-101 interferon gamma Homo sapiens 188-197 7588238-5 1995 IFN gamma increased the production of inositol mono-, bis-, and trisphosphates and caused a dose-dependent increase in intracellular Ca2+ ([Ca2+]i) at 37 C. Preincubation with 12-O-tetradecanoylphorbol-13-acetate, which activates protein kinase C, resulted in the abolition of the IFN gamma response, suggesting that protein kinase C was involved in a negative feedback loop resulting in inhibition of IFN gamma-induced [Ca2+]i rise. 12-o 176-180 interferon gamma Homo sapiens 0-9 7588238-5 1995 IFN gamma increased the production of inositol mono-, bis-, and trisphosphates and caused a dose-dependent increase in intracellular Ca2+ ([Ca2+]i) at 37 C. Preincubation with 12-O-tetradecanoylphorbol-13-acetate, which activates protein kinase C, resulted in the abolition of the IFN gamma response, suggesting that protein kinase C was involved in a negative feedback loop resulting in inhibition of IFN gamma-induced [Ca2+]i rise. 12-o 176-180 interferon gamma Homo sapiens 281-290 7588238-5 1995 IFN gamma increased the production of inositol mono-, bis-, and trisphosphates and caused a dose-dependent increase in intracellular Ca2+ ([Ca2+]i) at 37 C. Preincubation with 12-O-tetradecanoylphorbol-13-acetate, which activates protein kinase C, resulted in the abolition of the IFN gamma response, suggesting that protein kinase C was involved in a negative feedback loop resulting in inhibition of IFN gamma-induced [Ca2+]i rise. 12-o 176-180 interferon gamma Homo sapiens 281-290 7588238-5 1995 IFN gamma increased the production of inositol mono-, bis-, and trisphosphates and caused a dose-dependent increase in intracellular Ca2+ ([Ca2+]i) at 37 C. Preincubation with 12-O-tetradecanoylphorbol-13-acetate, which activates protein kinase C, resulted in the abolition of the IFN gamma response, suggesting that protein kinase C was involved in a negative feedback loop resulting in inhibition of IFN gamma-induced [Ca2+]i rise. tetradecanoylphorbol-13-acetate 181-212 interferon gamma Homo sapiens 0-9 7588238-6 1995 Prior release of intracellularly stored Ca2+ with thapsigargin, the microsomal Ca2+ pump inhibitor, also abolished the response of IFN gamma. Thapsigargin 50-62 interferon gamma Homo sapiens 131-140 7588238-8 1995 The tyrosine protein kinase inhibitor, genistein, inhibited the production of inositol phosphates and the elevation of [Ca2+]i induced by IFN gamma, but had no effect on ATP, suggesting that tyrosine protein kinase is involved in the signaling transduction of IFN gamma. Genistein 39-48 interferon gamma Homo sapiens 138-147 7588238-8 1995 The tyrosine protein kinase inhibitor, genistein, inhibited the production of inositol phosphates and the elevation of [Ca2+]i induced by IFN gamma, but had no effect on ATP, suggesting that tyrosine protein kinase is involved in the signaling transduction of IFN gamma. Genistein 39-48 interferon gamma Homo sapiens 260-269 7588238-9 1995 We conclude that the mobilization of intracellular Ca2+ and the production of inositol phosphates are two important signaling events for the action of IFN gamma in human thyrocytes. Inositol Phosphates 78-97 interferon gamma Homo sapiens 151-160 7588238-0 1995 Interferon-gamma increases intracellular calcium and inositol phosphates in primary human thyroid cell culture. Inositol Phosphates 53-72 interferon gamma Homo sapiens 0-16 7588238-4 1995 We studied the action of IFN gamma on the production of inositol phosphates and intracellular Ca2+ mobilization in primary cultures of human thyrocytes using the fluorescent Ca2+ indicator fura-2. Inositol Phosphates 56-75 interferon gamma Homo sapiens 25-34 7588238-5 1995 IFN gamma increased the production of inositol mono-, bis-, and trisphosphates and caused a dose-dependent increase in intracellular Ca2+ ([Ca2+]i) at 37 C. Preincubation with 12-O-tetradecanoylphorbol-13-acetate, which activates protein kinase C, resulted in the abolition of the IFN gamma response, suggesting that protein kinase C was involved in a negative feedback loop resulting in inhibition of IFN gamma-induced [Ca2+]i rise. inositol mono-, bis-, and trisphosphates 38-78 interferon gamma Homo sapiens 0-9 8550072-5 1995 With adult purified T cells, high levels of IL-10 and IL-4 were measured following CD3 plus CD28 stimulation, and the amounts of both T-helper type-2 (Th2) cytokines decreased following the addition of phorbol myristate acetate (PMA), whereas the synthesis of the Th1 cytokines IL-2 and IFN-gamma was enhanced. Tetradecanoylphorbol Acetate 202-227 interferon gamma Homo sapiens 287-296 21153120-0 1995 Effect of 17beta-oestradiol on expression of IL-2, IL-6 and IFN-gamma mRNA in human tonsillar cells. Estradiol 10-27 interferon gamma Homo sapiens 60-69 7594575-6 1995 However, they mobilized intracellular calcium following stimulation with Ca(2+)-ionophore and produced all of the above cytokines, including IFN-gamma, when stimulated with phorbol ester and Ca2+ ionophore. Phorbol Esters 173-186 interferon gamma Homo sapiens 141-150 8563891-6 1995 IFN-gamma production and B7-2 expression in the LPMC of CD were higher than in the LPMC of UC and controls, and high levels of B7-2 expression were observed on the LPMC of CD after incubation with endotoxin. lpmc 48-52 interferon gamma Homo sapiens 0-9 7595201-7 1995 The CHO cell lines, IFN-gamma-treated human peripheral-blood monocytes, and IFN-gamma-treated cells of the human monocytic cell line THP-1 all secreted multiple and identical HuMig species as revealed by SDS-PAGE. Sodium Dodecyl Sulfate 204-207 interferon gamma Homo sapiens 76-85 8563891-6 1995 IFN-gamma production and B7-2 expression in the LPMC of CD were higher than in the LPMC of UC and controls, and high levels of B7-2 expression were observed on the LPMC of CD after incubation with endotoxin. lpmc 83-87 interferon gamma Homo sapiens 0-9 8563891-6 1995 IFN-gamma production and B7-2 expression in the LPMC of CD were higher than in the LPMC of UC and controls, and high levels of B7-2 expression were observed on the LPMC of CD after incubation with endotoxin. lpmc 83-87 interferon gamma Homo sapiens 0-9 8563891-7 1995 The induction of B7-2 on the LPMC of CD may provide a mechanism for the amplification of T cell proliferation and lymphokine production by IFN-gamma-activated LPMC. lpmc 29-33 interferon gamma Homo sapiens 139-148 8563891-7 1995 The induction of B7-2 on the LPMC of CD may provide a mechanism for the amplification of T cell proliferation and lymphokine production by IFN-gamma-activated LPMC. lpmc 159-163 interferon gamma Homo sapiens 139-148 7595510-2 1995 Cell lines obtained from astrocytoma, neuroblastoma, macrophage/monocytes, lung, and liver metabolized L-[13C6]-tryptophan to L-[13C6]kynurenine and [13C6]kynurenate, particularly after indoleamine-2,3-dioxygenase induction by interferon-gamma. l-[13c6]-tryptophan 103-122 interferon gamma Homo sapiens 227-243 7595061-5 1995 Cycloheximide treatment of the cultures containing M-CSF and IFN-gamma inhibited the production of IL-1 beta and TNF-alpha. Cycloheximide 0-13 interferon gamma Homo sapiens 61-70 7578267-0 1995 Cooperative effects of interferon-gamma on the induction of NADPH oxidase by retinoic acid or 1,25(OH)2-vitamin D3 in monocytic U937 cells. Tretinoin 77-90 interferon gamma Homo sapiens 23-39 8590304-8 1995 Consistent with mammalian IFN-gamma, the nitrite-inducing activity was found to be heat labile, with over 90% of the activity lost within 5 minutes of heating. Nitrites 41-48 interferon gamma Homo sapiens 26-35 8590305-2 1995 CC8.1h constitutively produces IFN activity that shares physiochemical properties with mammalian IFN-gamma. cc8 0-3 interferon gamma Homo sapiens 97-106 8590305-2 1995 CC8.1h constitutively produces IFN activity that shares physiochemical properties with mammalian IFN-gamma. Hydrogen 4-6 interferon gamma Homo sapiens 97-106 8590308-0 1995 Inhibition of vitamin D3-induced cell differentiation by interferon-gamma in HL-60 cells determined by a nitroblue tetrazolium reduction test. Cholecalciferol 14-24 interferon gamma Homo sapiens 57-73 8590308-0 1995 Inhibition of vitamin D3-induced cell differentiation by interferon-gamma in HL-60 cells determined by a nitroblue tetrazolium reduction test. Nitroblue Tetrazolium 105-126 interferon gamma Homo sapiens 57-73 8590308-6 1995 IFN-gamma seems to act as a specific inhibitor for 1,25(OH)2D3-induced cell differentiation. Calcitriol 51-62 interferon gamma Homo sapiens 0-9 8590308-7 1995 To elucidate the cause of the inhibition of cell differentiation by IFN-gamma, the ability of the cells to produce superoxide (O2-) was examined after culture for 5 days in the presence of 1,25(OH)2D3 and IFN-gamma. Superoxides 115-125 interferon gamma Homo sapiens 68-77 8590308-8 1995 The results indicated that the inhibition of IFN-gamma was caused by a reduction in the ability of the cells to produce O2- in response to stimulation by 12-O-tetradecanoylphorbol-13-acetate (TPA). Superoxides 120-122 interferon gamma Homo sapiens 45-54 8590308-8 1995 The results indicated that the inhibition of IFN-gamma was caused by a reduction in the ability of the cells to produce O2- in response to stimulation by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 154-190 interferon gamma Homo sapiens 45-54 8590308-8 1995 The results indicated that the inhibition of IFN-gamma was caused by a reduction in the ability of the cells to produce O2- in response to stimulation by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 192-195 interferon gamma Homo sapiens 45-54 8551796-5 1995 Like DMSO, all interferons potentiated TNF-induced cytotoxicity, IFN beta 1 and IFN gamma being the most potent in this respect. Dimethyl Sulfoxide 5-9 interferon gamma Homo sapiens 80-89 8551796-6 1995 When applied together, DMSO and IFN gamma enhanced TNF-mediated cell lysis in either an additive (in the case of U937, THP1, HL60 cells) or a synergistic (in the case of KG1) manner, suggesting that the mechanisms of the potentiating activity of DMSO and IFN gamma are different. Dimethyl Sulfoxide 23-27 interferon gamma Homo sapiens 255-264 8551796-6 1995 When applied together, DMSO and IFN gamma enhanced TNF-mediated cell lysis in either an additive (in the case of U937, THP1, HL60 cells) or a synergistic (in the case of KG1) manner, suggesting that the mechanisms of the potentiating activity of DMSO and IFN gamma are different. Dimethyl Sulfoxide 246-250 interferon gamma Homo sapiens 32-41 7578267-0 1995 Cooperative effects of interferon-gamma on the induction of NADPH oxidase by retinoic acid or 1,25(OH)2-vitamin D3 in monocytic U937 cells. Calcitriol 94-114 interferon gamma Homo sapiens 23-39 7578267-2 1995 Differentiation with the combination of either RA (1 microM) or 1,25-D3 (10 nM) with IFN-gamma (100 IU/ml) induced NADPH oxidase activity as demonstrated by increased superoxide anion (O2-) generation in response to stimulation with phorbol myristate acetate (PMA, 100 nM). Calcitriol 64-71 interferon gamma Homo sapiens 85-94 7578267-2 1995 Differentiation with the combination of either RA (1 microM) or 1,25-D3 (10 nM) with IFN-gamma (100 IU/ml) induced NADPH oxidase activity as demonstrated by increased superoxide anion (O2-) generation in response to stimulation with phorbol myristate acetate (PMA, 100 nM). Superoxides 167-183 interferon gamma Homo sapiens 85-94 7578267-2 1995 Differentiation with the combination of either RA (1 microM) or 1,25-D3 (10 nM) with IFN-gamma (100 IU/ml) induced NADPH oxidase activity as demonstrated by increased superoxide anion (O2-) generation in response to stimulation with phorbol myristate acetate (PMA, 100 nM). Superoxides 185-187 interferon gamma Homo sapiens 85-94 7578267-2 1995 Differentiation with the combination of either RA (1 microM) or 1,25-D3 (10 nM) with IFN-gamma (100 IU/ml) induced NADPH oxidase activity as demonstrated by increased superoxide anion (O2-) generation in response to stimulation with phorbol myristate acetate (PMA, 100 nM). Tetradecanoylphorbol Acetate 233-258 interferon gamma Homo sapiens 85-94 7578267-2 1995 Differentiation with the combination of either RA (1 microM) or 1,25-D3 (10 nM) with IFN-gamma (100 IU/ml) induced NADPH oxidase activity as demonstrated by increased superoxide anion (O2-) generation in response to stimulation with phorbol myristate acetate (PMA, 100 nM). Tetradecanoylphorbol Acetate 260-263 interferon gamma Homo sapiens 85-94 7570980-8 1995 Although cyclosporine suppressed the secretion of both IL-2 and IFN-gamma, there was no difference in sensitivity to suppression between rejectors and nonrejectors. Cyclosporine 9-21 interferon gamma Homo sapiens 64-73 7575617-1 1995 Human retinal pigment epithelial (RPE) cells in culture respond to a mixture of cytokines (IFN-gamma, IL-1 beta, TNF-alpha) by producing large amounts of nitric oxide. Nitric Oxide 154-166 interferon gamma Homo sapiens 91-100 7589546-2 1995 NO production is induced in interferon-gamma and lipopolysaccharide stimulated RAW-264.7 macrophages as indicated by the increase of NO2- in the medium. Nitrogen Dioxide 133-136 interferon gamma Homo sapiens 28-44 8580276-5 1995 Eight weeks" treatment with the immunosuppressive agents cyclosporin, or with corticosteroids, produced a significant reduction in the percentage of IL-2 secreting cells, although only for the former was there also a reduction in interferon-gamma secreting cells. Cyclosporine 57-68 interferon gamma Homo sapiens 230-246 7545471-6 1995 Our results show that antiproliferative effect of IFN-gamma overrode mitogenic effect of CSF-1 and phorbol ester, as measured by early gene expression, DNA synthesis and cell proliferation. Phorbol Esters 99-112 interferon gamma Homo sapiens 50-59 7545471-7 1995 Although activation, phosphorylation, and turnover of the CSF-1 receptor and CSF-1-induced increase in diacylglycerol production remained normal, IFN-gamma blocked CSF-1-stimulated activation of mitogen-activated protein kinases, Raf-1 kinase, increase in GTP-bound Ras and tyrosine phosphorylation, and activation of protein kinase C delta (PKC-delta). Guanosine Triphosphate 256-259 interferon gamma Homo sapiens 146-155 7545471-7 1995 Although activation, phosphorylation, and turnover of the CSF-1 receptor and CSF-1-induced increase in diacylglycerol production remained normal, IFN-gamma blocked CSF-1-stimulated activation of mitogen-activated protein kinases, Raf-1 kinase, increase in GTP-bound Ras and tyrosine phosphorylation, and activation of protein kinase C delta (PKC-delta). Tyrosine 274-282 interferon gamma Homo sapiens 146-155 7671315-4 1995 Similarly, dexamethasone decreased HLA-DR expression on epithelial and monocytic cell lines that express HLA-DR upon IFN-gamma treatment. Dexamethasone 11-24 interferon gamma Homo sapiens 117-126 7554401-5 1995 Importantly, the levels of mRNA encoding c-myc, IL-2R alpha, IL-2 and IFN-gamma were markedly decreased in patient lymphocytes stimulated with PMA+ionomycin as compared to control lymphocytes. Tetradecanoylphorbol Acetate 143-146 interferon gamma Homo sapiens 70-79 7554401-5 1995 Importantly, the levels of mRNA encoding c-myc, IL-2R alpha, IL-2 and IFN-gamma were markedly decreased in patient lymphocytes stimulated with PMA+ionomycin as compared to control lymphocytes. Ionomycin 147-156 interferon gamma Homo sapiens 70-79 7671315-5 1995 In total, these results suggest that dexamethasone inhibits both constitutive and IFN-gamma-inducible MHC class II expression in several cell types. Dexamethasone 37-50 interferon gamma Homo sapiens 82-91 7671317-2 1995 Nickel-reactive T cells described so far display a TH1 lymphokine secretion pattern characterized by high amounts of IFN gamma, but little or no IL-4 and IL-5. Nickel 0-6 interferon gamma Homo sapiens 117-126 7671317-5 1995 These TCC responded to nickel with the production of high levels of IL-5 and variable amounts of IFN-gamma and IL-4 resembling TH2- or TH0-like cytokine secretion pattern. Nickel 23-29 interferon gamma Homo sapiens 97-106 7545102-5 1995 Induction of NO formation by thyrocytes upon stimulation with IL-1 alpha + IFN-gamma was accompanied by the synthesis of tetrahydrobiopterin (BH4), an obligatory cofactor of NOS. sapropterin 121-140 interferon gamma Homo sapiens 75-84 7545102-11 1995 Thus, cytokines such as IL-1, IL-1/IFN-gamma, and tumor necrosis factor-alpha/IFN-gamma stimulate human thyrocytes to produce NO; this process can be modulated by other cytokines and coregulated with a cofactor BH4 biosynthesis, and resulting NO may affect cell function including thyroid hormone synthesis. sapropterin 211-214 interferon gamma Homo sapiens 78-87 7560666-11 1995 A clinical history of aspirin sensitivity was strongly correlated with nonallergic CHS/NP, as well as the nonallergic CHS/NP profile of cytokines, including IFN-gamma. Aspirin 22-29 interferon gamma Homo sapiens 157-166 7549507-7 1995 The results show that tetrandrine may inhibit (1) MNC proliferation, (2) the production of IL-2, IL-4 and IFN-gamma, and (3) the expression of HLA-DR, CD23 and CD25 on CD3 positive T cells. tetrandrine 22-33 interferon gamma Homo sapiens 106-115 7561055-0 1995 Superantigen-induced collagenase gene expression in human IFN-gamma-treated fibroblast-like synoviocytes involves prostaglandin E2. Dinoprostone 114-130 interferon gamma Homo sapiens 58-67 7560666-16 1995 Aspirin sensitivity is strongly correlated with nonallergic CHS/NP and production of the nonallergic CHS/NP profile of cytokines, including IFN-gamma. Aspirin 0-7 interferon gamma Homo sapiens 140-149 7556623-1 1995 Herbimycin A, a potent tyrosine kinase inhibitor, suppressed nitric oxide synthase (NOS) induced by lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) in C6 glial cells. herbimycin 0-12 interferon gamma Homo sapiens 129-145 7556623-1 1995 Herbimycin A, a potent tyrosine kinase inhibitor, suppressed nitric oxide synthase (NOS) induced by lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) in C6 glial cells. herbimycin 0-12 interferon gamma Homo sapiens 147-156 7556623-3 1995 In addition, IFN-gamma activated the tyrosine protein kinase, JAK2, and tyrosine-phosphorylation by itself was also inhibited by herbimycin A. Tyrosine 37-45 interferon gamma Homo sapiens 13-22 7556623-3 1995 In addition, IFN-gamma activated the tyrosine protein kinase, JAK2, and tyrosine-phosphorylation by itself was also inhibited by herbimycin A. Tyrosine 72-80 interferon gamma Homo sapiens 13-22 7556623-3 1995 In addition, IFN-gamma activated the tyrosine protein kinase, JAK2, and tyrosine-phosphorylation by itself was also inhibited by herbimycin A. herbimycin 129-141 interferon gamma Homo sapiens 13-22 7556623-4 1995 These results suggest that herbimycin A suppresses iNOS induction by inhibition of both NF-kappa B activation caused by LPS, and tyrosine-phosphorylation of JAK2 caused by IFN-gamma in C6 glioma cells. herbimycin 27-39 interferon gamma Homo sapiens 172-181 7556623-4 1995 These results suggest that herbimycin A suppresses iNOS induction by inhibition of both NF-kappa B activation caused by LPS, and tyrosine-phosphorylation of JAK2 caused by IFN-gamma in C6 glioma cells. Tyrosine 129-137 interferon gamma Homo sapiens 172-181 8552275-4 1995 Actinomycin D, inhibited C3 gene induction by IFN-gamma and IL-1 beta suggesting that these cytokines act, in part, at the transcriptional level to enhance C3 expression. Dactinomycin 0-13 interferon gamma Homo sapiens 46-55 7670961-1 1995 The amino acid sequence of interferon gamma (IFN-gamma) has basic amino acid clusters similar to the heparin-binding consensus sequences found in other proteins that bind to proteoglycans (PGs). Amino Acids, Basic 60-76 interferon gamma Homo sapiens 27-54 7670961-1 1995 The amino acid sequence of interferon gamma (IFN-gamma) has basic amino acid clusters similar to the heparin-binding consensus sequences found in other proteins that bind to proteoglycans (PGs). Heparin 101-108 interferon gamma Homo sapiens 27-54 7670961-4 1995 The binding of 125I-IFN-gamma to ECM was reduced significantly by pretreatment of ECM with chondroitinase ABC, an enzyme that degrades chondroitin-sulfate glycosaminoglycans. chondroitin sulfate glycosaminoglycan 135-173 interferon gamma Homo sapiens 20-29 7670961-5 1995 IFN-gamma binding to ECM was reduced by increasing concentrations of chondroitin-6-sulfate. Chondroitin Sulfates 69-90 interferon gamma Homo sapiens 0-9 7670961-8 1995 The binding to chondroitin-sulfate PGs was confirmed by affinity chromatography of isolated [35S]chondroitin-sulfate PGs from ECM and cell-culture medium on immobilized IFN-gamma. Chondroitin Sulfates 15-34 interferon gamma Homo sapiens 169-178 7670961-8 1995 The binding to chondroitin-sulfate PGs was confirmed by affinity chromatography of isolated [35S]chondroitin-sulfate PGs from ECM and cell-culture medium on immobilized IFN-gamma. Sulfur-35 93-96 interferon gamma Homo sapiens 169-178 7670961-8 1995 The binding to chondroitin-sulfate PGs was confirmed by affinity chromatography of isolated [35S]chondroitin-sulfate PGs from ECM and cell-culture medium on immobilized IFN-gamma. Chondroitin Sulfates 97-116 interferon gamma Homo sapiens 169-178 7670961-11 1995 These results suggest a role for chondroitin-sulfate PGs in immobilizing IFN-gamma in the ECM compartment and enhancing the cellular response to IFN-gamma. Chondroitin Sulfates 33-52 interferon gamma Homo sapiens 73-82 7670961-11 1995 These results suggest a role for chondroitin-sulfate PGs in immobilizing IFN-gamma in the ECM compartment and enhancing the cellular response to IFN-gamma. Chondroitin Sulfates 33-52 interferon gamma Homo sapiens 145-154 8572604-2 1995 Following 24 hr treatment interferon-gamma inhibited thymidine incorporation into DNA and thymidine kinase activity, but no significant effect on cell number was observed. Thymidine 53-62 interferon gamma Homo sapiens 26-42 8572604-5 1995 N alpha-tosyl-L-lysyl-chloromethane, a serine protease inhibitor which also serves as a tyrosine protein kinase inhibitor, partially reversed the effect of interferon-gamma at a concentration of 100 microM. n alpha-tosyl-l-lysyl-chloromethane 0-35 interferon gamma Homo sapiens 156-172 8572604-6 1995 The bioflavonoid, quercetin, a non-specific tyrosine protein kinase inhibitor, at a concentration of 30 microM completely abolished the action of interferon-gamma on thymidine incorporation. Flavonoids 4-16 interferon gamma Homo sapiens 146-162 8572604-6 1995 The bioflavonoid, quercetin, a non-specific tyrosine protein kinase inhibitor, at a concentration of 30 microM completely abolished the action of interferon-gamma on thymidine incorporation. Quercetin 18-27 interferon gamma Homo sapiens 146-162 8572604-6 1995 The bioflavonoid, quercetin, a non-specific tyrosine protein kinase inhibitor, at a concentration of 30 microM completely abolished the action of interferon-gamma on thymidine incorporation. Thymidine 166-175 interferon gamma Homo sapiens 146-162 8861714-1 1995 The combination of lipopolysaccharide (LPS; 100 ng/ml) and interferon-gamma (IFN-gamma; 10 IU/ml) synergistically stimulated induction of nitric oxide synthase activity in J774 macrophages, measured by nitrite accumulation during an overnight incubation. Nitrites 202-209 interferon gamma Homo sapiens 59-75 8861714-1 1995 The combination of lipopolysaccharide (LPS; 100 ng/ml) and interferon-gamma (IFN-gamma; 10 IU/ml) synergistically stimulated induction of nitric oxide synthase activity in J774 macrophages, measured by nitrite accumulation during an overnight incubation. Nitrites 202-209 interferon gamma Homo sapiens 77-86 8861714-4 1995 Phorbol 12-myristate 13-acetate (10(-9) - 3 x 10(-6) M) produced a concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but enhanced nitrite accumulation when added 12 hours following stimulation with LPS and IFN-gamma. Tetradecanoylphorbol Acetate 0-31 interferon gamma Homo sapiens 171-180 8861714-4 1995 Phorbol 12-myristate 13-acetate (10(-9) - 3 x 10(-6) M) produced a concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but enhanced nitrite accumulation when added 12 hours following stimulation with LPS and IFN-gamma. Tetradecanoylphorbol Acetate 0-31 interferon gamma Homo sapiens 271-280 8861714-5 1995 Of the protein kinase C inhibitors tested, staurosporine (10(-9) - 3 x 10(-6) M) and Ro 31-8220 (3 x 10(-9) - 10(-5) M) produced a powerful, concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but had only slight inhibitory effects when added 12 hours after stimulation with LPS and IFN-gamma. Staurosporine 43-56 interferon gamma Homo sapiens 245-254 8861714-5 1995 Of the protein kinase C inhibitors tested, staurosporine (10(-9) - 3 x 10(-6) M) and Ro 31-8220 (3 x 10(-9) - 10(-5) M) produced a powerful, concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but had only slight inhibitory effects when added 12 hours after stimulation with LPS and IFN-gamma. Staurosporine 43-56 interferon gamma Homo sapiens 346-355 8861714-6 1995 Chelerythrine chloride ( 10(-8) - 3 x 10(-5) M) produced only a slight inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but slightly enhanced nitrite accumulation when added 12 hours following stimulation with LPS and IFN-gamma. chelerythrine 0-22 interferon gamma Homo sapiens 151-160 8861714-6 1995 Chelerythrine chloride ( 10(-8) - 3 x 10(-5) M) produced only a slight inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but slightly enhanced nitrite accumulation when added 12 hours following stimulation with LPS and IFN-gamma. chelerythrine 0-22 interferon gamma Homo sapiens 260-269 8861714-7 1995 The tyrosine kinase inhibitors, genistein (10(-7) - 10(-4) M) and herbimycin A (5.2 x 10(-9) - 1.74 x 10(-6) M), produced a powerful concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma. Genistein 32-41 interferon gamma Homo sapiens 237-246 8861714-7 1995 The tyrosine kinase inhibitors, genistein (10(-7) - 10(-4) M) and herbimycin A (5.2 x 10(-9) - 1.74 x 10(-6) M), produced a powerful concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma. herbimycin 66-78 interferon gamma Homo sapiens 237-246 8861714-8 1995 In contrast, herbimycin A had only a slight inhibitory effect when added 12 hours following stimulation with LPS and IFN-gamma, and genistein had no effect. herbimycin 13-25 interferon gamma Homo sapiens 117-126 8861714-9 1995 When used in combination prior to stimulation with LPS and IFN-gamma, herbimycin A (1.7 x 10(-7) M) and staurosporine (3 x 10(-8) M) produced additive inhibitory effects on nitrite accumulation, but herbimycin A, together with Ro 31-8220 (3 x 10(-6) M) or chelerythrine chloride (10(-5) M), produced no further effects. herbimycin 70-82 interferon gamma Homo sapiens 59-68 8861714-9 1995 When used in combination prior to stimulation with LPS and IFN-gamma, herbimycin A (1.7 x 10(-7) M) and staurosporine (3 x 10(-8) M) produced additive inhibitory effects on nitrite accumulation, but herbimycin A, together with Ro 31-8220 (3 x 10(-6) M) or chelerythrine chloride (10(-5) M), produced no further effects. Staurosporine 104-117 interferon gamma Homo sapiens 59-68 7544574-5 1995 In the presence of limiting concentrations (micromolar) of ATP, activation was also dependent upon stimulation with IFN-gamma, whereas at millimolar concentrations of ATP, gamma RF-1 was activated by either sodium orthovanadate or pervanadate in the absence of ligand. Adenosine Triphosphate 59-62 interferon gamma Homo sapiens 116-125 7544575-3 1995 The addition of NG-monomethyl-L-arginine, a selective inhibitor of NO synthesis, reduced the effect of interferon-gamma and lipopolysaccharide, while the effect of NG-monomethyl-L-arginine was suppressed by the addition of L-arginine, a substrate of NO synthase. omega-N-Methylarginine 16-40 interferon gamma Homo sapiens 103-119 7544575-3 1995 The addition of NG-monomethyl-L-arginine, a selective inhibitor of NO synthesis, reduced the effect of interferon-gamma and lipopolysaccharide, while the effect of NG-monomethyl-L-arginine was suppressed by the addition of L-arginine, a substrate of NO synthase. Arginine 30-40 interferon gamma Homo sapiens 103-119 7654188-1 1995 Interferon (IFN)-gamma, in common with a number of cytokines or growth factors, strongly interacts with heparan sulphate (HS). Heparitin Sulfate 104-120 interferon gamma Homo sapiens 0-22 7654188-1 1995 Interferon (IFN)-gamma, in common with a number of cytokines or growth factors, strongly interacts with heparan sulphate (HS). Heparitin Sulfate 122-124 interferon gamma Homo sapiens 0-22 7654188-4 1995 IFN-gamma-affinity chromatography of HS oligosaccharides released by either enzymic or chemical cleavage showed that the binding site is not found in a domain that is resistant to either heparinase or heparitinase or exclusively N-sulphated or N-acetylated. hs oligosaccharides 37-56 interferon gamma Homo sapiens 0-9 7561055-10 1995 In conclusion, this work demonstrates a selective induction of collagenase gene expression over its natural inhibitor TIMP in human IFN-gamma-treated fibroblast-like synoviocytes mediated, at least in part, by PGE2, and provides evidence that signaling via MHC class II molecules induces the production of PGE2 through enhanced production of COX-2 and possibly activation of the cPLA2. Dinoprostone 210-214 interferon gamma Homo sapiens 132-141 7654188-5 1995 This led us to take a "footprinting" approach in which HS was depolymerized in the presence of IFN-gamma and the cytokine-protected sequences were separated from the digested fragments. Heparitin Sulfate 55-57 interferon gamma Homo sapiens 95-104 7654188-12 1995 Furthermore, using a cross-linking strategy, we demonstrated that one HS molecule bound to an IFN-gamma dimer. Heparitin Sulfate 70-72 interferon gamma Homo sapiens 94-103 7561055-10 1995 In conclusion, this work demonstrates a selective induction of collagenase gene expression over its natural inhibitor TIMP in human IFN-gamma-treated fibroblast-like synoviocytes mediated, at least in part, by PGE2, and provides evidence that signaling via MHC class II molecules induces the production of PGE2 through enhanced production of COX-2 and possibly activation of the cPLA2. Dinoprostone 306-310 interferon gamma Homo sapiens 132-141 7561155-5 1995 Digital image processing analysis demonstrated that SEB induced a transient increase of intracellular calcium concentration only in the IFN-gamma-treated DJM-1 cells. Calcium 102-109 interferon gamma Homo sapiens 136-145 7498243-4 1995 A potential candidate is neopterin which is released by monocytes/macrophages when stimulated with IFN-gamma, excreted unchanged in urine, and appears to be an early and sensitive marker for activation of the immune system. Neopterin 25-34 interferon gamma Homo sapiens 99-108 8847103-4 1995 On the contrary, ATP and glutamate treatment of astrocytes prior to a combination of interleukin-1 beta and interferon-gamma markedly reduced (30-50%) subsequent NOS mRNA expression. Adenosine Triphosphate 17-20 interferon gamma Homo sapiens 108-124 8847103-4 1995 On the contrary, ATP and glutamate treatment of astrocytes prior to a combination of interleukin-1 beta and interferon-gamma markedly reduced (30-50%) subsequent NOS mRNA expression. Glutamic Acid 25-34 interferon gamma Homo sapiens 108-124 7590886-6 1995 Enzyme induction, as well as the anti-parasitic effect, was blocked by a monoclonal antibody directed against interferon-gamma (IFN-gamma), and the addition of L-tryptophan to the cultures completely blocked the anti-parasitic effect induced by T-cell supernatants. Tryptophan 160-172 interferon gamma Homo sapiens 128-137 8846199-4 1995 Dexamethasone strongly inhibited the production of IL-5 (IC50 = 0.004 microM), was less potent against IL-2 and IFN-gamma (IC50 = 0.02-0.05 microM) and showed a relatively weak effect against GM-CSF (IC50 = 0.6 microM). Dexamethasone 0-13 interferon gamma Homo sapiens 112-121 8846199-5 1995 Similarly prednisolone potently suppressed IL-5 generation (IC50 = 0.05 microM), displayed a more modest activity on IL-2 and IFn-gamma (IC50 = 0.2-0.3 microM) and exerted only partial effects (43% inhibition at 1 microM) on GM-CSF). Prednisolone 10-22 interferon gamma Homo sapiens 126-135 8846199-6 1995 FK506 strongly suppressed the production of IL-2 (IC50 = 0.01 microM) and GM-CSF (IC50 = 0.03 microM), but was inactive (< 30% inhibition at 1 microM) against IL-5 and IFN-gamma. Tacrolimus 0-5 interferon gamma Homo sapiens 171-180 7657660-3 1995 Co-expression of Stat1 with Tyk2, Jak1, or Jak2 resulted in the specific tyrosine phosphorylation of Stat1 at Tyr701, the residue phosphorylated in mammalian cells stimulated with interferon gamma. Tyrosine 73-81 interferon gamma Homo sapiens 180-196 7498243-10 1995 There was a good correlation between serum IFN-gamma and urine neopterin. Neopterin 63-72 interferon gamma Homo sapiens 43-52 7650395-7 1995 Penicillin G and BPO-HSA-specific T cell clones produced a heterogeneous cytokine pattern as most clones produced high amounts of IL-2, IFN-gamma, TFN-alpha, and rather variable levels of IL-4 and IL-5. Penicillin G 0-12 interferon gamma Homo sapiens 136-145 7673410-10 1995 Ganglioside profiles were invariant with respect to treatment of fibroblasts with interferon-gamma. Gangliosides 0-11 interferon gamma Homo sapiens 82-98 7650395-7 1995 Penicillin G and BPO-HSA-specific T cell clones produced a heterogeneous cytokine pattern as most clones produced high amounts of IL-2, IFN-gamma, TFN-alpha, and rather variable levels of IL-4 and IL-5. bpo-hsa 17-24 interferon gamma Homo sapiens 136-145 7665918-2 1995 In addition, IFN-gamma also exerts potent effects on cellular tryptophan levels by inducing the expression of indoleamine 2,3-dioxygenase (IDO) and tryptophanyl-tRNA synthetase. Tryptophan 62-72 interferon gamma Homo sapiens 13-22 7543934-1 1995 A nitric oxide (NO) synthase (NOS) can be induced in both astrocytes and cerebral endothelial cells with a combination of interleukin-1 beta/interferon-gamma or lipopolysaccharide/interferon-gamma, respectively. Nitric Oxide 2-14 interferon gamma Homo sapiens 141-157 7543934-1 1995 A nitric oxide (NO) synthase (NOS) can be induced in both astrocytes and cerebral endothelial cells with a combination of interleukin-1 beta/interferon-gamma or lipopolysaccharide/interferon-gamma, respectively. Nitric Oxide 2-14 interferon gamma Homo sapiens 180-196 7650373-8 1995 Chronic GVHD in the DBA-into-BDF1 model was found to be caused by a relative defect in the ability of DBA CD8+ T cells to induce acute GVHD and to produce IFN-gamma. 1,2,5,6-dibenzanthracene 20-23 interferon gamma Homo sapiens 155-164 7650373-8 1995 Chronic GVHD in the DBA-into-BDF1 model was found to be caused by a relative defect in the ability of DBA CD8+ T cells to induce acute GVHD and to produce IFN-gamma. 1,2,5,6-dibenzanthracene 102-105 interferon gamma Homo sapiens 155-164 8536105-1 1995 Interferon-gamma (IFN-gamma) is a priming agent of polymorphonuclear neutrophilic granulocyte (PMN) oxygen metabolism, and protein kinase C (PKC) is traditionally believed to play a central role in activation of this oxygen metabolism. Oxygen 100-106 interferon gamma Homo sapiens 0-16 8536105-1 1995 Interferon-gamma (IFN-gamma) is a priming agent of polymorphonuclear neutrophilic granulocyte (PMN) oxygen metabolism, and protein kinase C (PKC) is traditionally believed to play a central role in activation of this oxygen metabolism. Oxygen 100-106 interferon gamma Homo sapiens 18-27 8536105-1 1995 Interferon-gamma (IFN-gamma) is a priming agent of polymorphonuclear neutrophilic granulocyte (PMN) oxygen metabolism, and protein kinase C (PKC) is traditionally believed to play a central role in activation of this oxygen metabolism. Oxygen 217-223 interferon gamma Homo sapiens 0-16 8536105-1 1995 Interferon-gamma (IFN-gamma) is a priming agent of polymorphonuclear neutrophilic granulocyte (PMN) oxygen metabolism, and protein kinase C (PKC) is traditionally believed to play a central role in activation of this oxygen metabolism. Oxygen 217-223 interferon gamma Homo sapiens 18-27 8536105-8 1995 PMN oxygen metabolism, measured by flow cytometry as an accumulation of the fluorescent compound dichlorofluorescein, was in these experiments significantly primed by IFN-gamma, both at baseline and when stimulated with fMLP. Oxygen 4-10 interferon gamma Homo sapiens 167-176 8536105-8 1995 PMN oxygen metabolism, measured by flow cytometry as an accumulation of the fluorescent compound dichlorofluorescein, was in these experiments significantly primed by IFN-gamma, both at baseline and when stimulated with fMLP. 2',7'-dichlorofluorescein 97-116 interferon gamma Homo sapiens 167-176 7474452-6 1995 Conversion of L-tryptophan to QUIN has also been demonstrated in vitro in both brain tissue following macrophage infiltration, and in macrophages stimulated by interferon-gamma or HIV infection. Tryptophan 14-26 interferon gamma Homo sapiens 160-176 7474452-6 1995 Conversion of L-tryptophan to QUIN has also been demonstrated in vitro in both brain tissue following macrophage infiltration, and in macrophages stimulated by interferon-gamma or HIV infection. Quinolinic Acid 30-34 interferon gamma Homo sapiens 160-176 7474452-7 1995 Macrophages in vitro have a high capacity to synthesize QUIN following exposure to interferon-gamma, tumor necrosis factor-alpha, IL-1 beta and IL-6, compared to cells derived from other tissues. Quinolinic Acid 56-60 interferon gamma Homo sapiens 83-128 7543102-6 1995 Electrophoretic mobility shift assays demonstrate that CD16/Jak2 activates the ability of signal transduction and activation of transcription (STAT) proteins to bind to an interferon-gamma-activated sequence oligonucleotide in a manner similar to that seen after IL-3 treatment. Oligonucleotides 208-223 interferon gamma Homo sapiens 172-188 7665918-4 1995 IFN-gamma ( > or = 50 U/ml) stimulated IDO expression in human dermal fibroblasts in vitro, resulting in a > 90% depletion of tryptophan in the culture media following incubation for 48 h. Higher concentrations of IFN-gamma ( > or = 500 U/ml) caused a marked decrease in type I collagen mRNA levels. Tryptophan 132-142 interferon gamma Homo sapiens 0-9 7665918-7 1995 Addition of exogenous tryptophan (up to 2500 microM) to IFN-gamma-treated fibroblasts restored "normal" concentrations of tryptophan in the culture media, but did not abrogate the IFN-gamma-induced decrease in collagen mRNA. Tryptophan 22-32 interferon gamma Homo sapiens 56-65 7665918-7 1995 Addition of exogenous tryptophan (up to 2500 microM) to IFN-gamma-treated fibroblasts restored "normal" concentrations of tryptophan in the culture media, but did not abrogate the IFN-gamma-induced decrease in collagen mRNA. Tryptophan 122-132 interferon gamma Homo sapiens 56-65 7665918-9 1995 These results indicate that although IFN-gamma causes activation of IDO and enhanced tryptophan catabolism in fibroblast cultures, neither the ensuing tryptophan starvation nor the accumulation of kynurenine in the culture media can fully account for the inhibitory effects of IFN-gamma on type I collagen mRNA expression. Tryptophan 85-95 interferon gamma Homo sapiens 37-46 7648381-0 1995 IFN-gamma activates superoxide anion production in blood monocytes from allergic asthmatic patients. Superoxides 20-36 interferon gamma Homo sapiens 0-9 7648381-3 1995 Interferon-gamma (IFN-gamma), a monocyte-activating lymphokine, has been shown to prime monocytes for superoxide anion release. Superoxides 102-118 interferon gamma Homo sapiens 0-16 7648381-3 1995 Interferon-gamma (IFN-gamma), a monocyte-activating lymphokine, has been shown to prime monocytes for superoxide anion release. Superoxides 102-118 interferon gamma Homo sapiens 18-27 7648381-4 1995 OBJECTIVE: We hypothesized that IFN-gamma could directly activate blood monocyte superoxide anion release and evaluated its modulatory effect on IgE-induced superoxide anion release from those cells. Superoxides 81-97 interferon gamma Homo sapiens 32-41 7648381-4 1995 OBJECTIVE: We hypothesized that IFN-gamma could directly activate blood monocyte superoxide anion release and evaluated its modulatory effect on IgE-induced superoxide anion release from those cells. Superoxides 157-173 interferon gamma Homo sapiens 32-41 7648381-8 1995 RESULTS: We found that IFN-gamma stimulated superoxide anion production and decreased the IgE-induced superoxide anion production after 30 minutes of IFN-gamma preincubation only in blood monocytes from patients with allergic asthma. Superoxides 44-60 interferon gamma Homo sapiens 23-32 7648381-8 1995 RESULTS: We found that IFN-gamma stimulated superoxide anion production and decreased the IgE-induced superoxide anion production after 30 minutes of IFN-gamma preincubation only in blood monocytes from patients with allergic asthma. Superoxides 102-118 interferon gamma Homo sapiens 23-32 7648381-8 1995 RESULTS: We found that IFN-gamma stimulated superoxide anion production and decreased the IgE-induced superoxide anion production after 30 minutes of IFN-gamma preincubation only in blood monocytes from patients with allergic asthma. Superoxides 102-118 interferon gamma Homo sapiens 150-159 7543373-1 1995 We have examined the effects of two agents depleting the intracellular pool of glutathione (GSH) on macrophage activation induced by IFN-gamma + LPS, as measured by nitrite production and leishmanicidal activity. Glutathione 79-90 interferon gamma Homo sapiens 133-142 7542498-7 1995 Peritoneal macrophages have significantly enhanced nitrite/nitrate production and NOS activity after treatment with LPS and/or IFN-gamma, whereas monocyte nitrite/nitrate production and NOS activity are not altered by the treatments. Nitrites 51-58 interferon gamma Homo sapiens 127-136 7543373-1 1995 We have examined the effects of two agents depleting the intracellular pool of glutathione (GSH) on macrophage activation induced by IFN-gamma + LPS, as measured by nitrite production and leishmanicidal activity. Glutathione 92-95 interferon gamma Homo sapiens 133-142 7543373-11 1995 Our results suggest that both soluble and protein-bound GSH may be important for the induction of NO synthase in IFN-gamma + LPS-activated macrophages. Glutathione 56-59 interferon gamma Homo sapiens 113-122 7614740-8 1995 At a concentration of 100 microU/ml, TSH enhanced IFN-gamma-induced HLA-DR expression. Thyrotropin 37-40 interferon gamma Homo sapiens 50-59 8591699-6 1995 Enhancement of the production of O2- and H2O2 occurred in healthy subjects (150% increase) as well as NIDDM patients (170% increase) after a preincubation of monocytes with interferon-gamma (IFN-gamma 100 U/ml) for 48 h. The respiratory burst activity of both fresh and cultured monocytes from well controlled NIDDM patients was not significantly different from that of healthy subjects. Oxygen 33-35 interferon gamma Homo sapiens 173-189 8591699-6 1995 Enhancement of the production of O2- and H2O2 occurred in healthy subjects (150% increase) as well as NIDDM patients (170% increase) after a preincubation of monocytes with interferon-gamma (IFN-gamma 100 U/ml) for 48 h. The respiratory burst activity of both fresh and cultured monocytes from well controlled NIDDM patients was not significantly different from that of healthy subjects. Oxygen 33-35 interferon gamma Homo sapiens 191-200 8591699-6 1995 Enhancement of the production of O2- and H2O2 occurred in healthy subjects (150% increase) as well as NIDDM patients (170% increase) after a preincubation of monocytes with interferon-gamma (IFN-gamma 100 U/ml) for 48 h. The respiratory burst activity of both fresh and cultured monocytes from well controlled NIDDM patients was not significantly different from that of healthy subjects. Hydrogen Peroxide 41-45 interferon gamma Homo sapiens 173-189 8591699-6 1995 Enhancement of the production of O2- and H2O2 occurred in healthy subjects (150% increase) as well as NIDDM patients (170% increase) after a preincubation of monocytes with interferon-gamma (IFN-gamma 100 U/ml) for 48 h. The respiratory burst activity of both fresh and cultured monocytes from well controlled NIDDM patients was not significantly different from that of healthy subjects. Hydrogen Peroxide 41-45 interferon gamma Homo sapiens 191-200 8591699-7 1995 This study suggests that both, strict metabolic control and in vitro culture with IFN-gamma may improve the monocyte oxygen-dependent bactericidal mechanism in NIDDM patients. Oxygen 117-123 interferon gamma Homo sapiens 82-91 7628352-4 1995 It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations. Arginine 210-218 interferon gamma Homo sapiens 43-59 7628352-4 1995 It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations. Arginine 210-218 interferon gamma Homo sapiens 61-70 7628352-4 1995 It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations. Citrulline 224-234 interferon gamma Homo sapiens 43-59 7628352-4 1995 It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations. Citrulline 224-234 interferon gamma Homo sapiens 61-70 7628352-4 1995 It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations. Arginine 285-293 interferon gamma Homo sapiens 43-59 7628352-4 1995 It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations. Arginine 285-293 interferon gamma Homo sapiens 61-70 7628352-9 1995 Both adult rat islets exposed to IL-1 beta and human pancreatic islets cultured in the presence of IL-1 beta, tumor necrosis factor-alpha, and IFN gamma were able to use citrulline to regenerate arginine and produce NO. Citrulline 170-180 interferon gamma Homo sapiens 143-152 7628352-9 1995 Both adult rat islets exposed to IL-1 beta and human pancreatic islets cultured in the presence of IL-1 beta, tumor necrosis factor-alpha, and IFN gamma were able to use citrulline to regenerate arginine and produce NO. Arginine 195-203 interferon gamma Homo sapiens 143-152 7543491-8 1995 NG-Monomethyl-L-arginine (MM-Arg), an NOS inhibitor, partially reversed the effects of TNF-alpha and, to a lesser extent, IFN-gamma in methylcellulose culture of total BM and CD34+ cells, and inhibited apoptosis of BM cells induced by these cytokines. omega-N-Methylarginine 0-24 interferon gamma Homo sapiens 122-131 7543491-8 1995 NG-Monomethyl-L-arginine (MM-Arg), an NOS inhibitor, partially reversed the effects of TNF-alpha and, to a lesser extent, IFN-gamma in methylcellulose culture of total BM and CD34+ cells, and inhibited apoptosis of BM cells induced by these cytokines. Arginine 28-32 interferon gamma Homo sapiens 122-131 7635985-7 1995 Cotransfection of JAK3 with IL-4 Stat into COS-7 cells produced an intracellular activity which bound the same IFN-gamma activation site-like sequence and comigrated with IL-4 NAF in electrophoretic mobility shift assay. carbonyl sulfide 43-46 interferon gamma Homo sapiens 111-120 7635985-7 1995 Cotransfection of JAK3 with IL-4 Stat into COS-7 cells produced an intracellular activity which bound the same IFN-gamma activation site-like sequence and comigrated with IL-4 NAF in electrophoretic mobility shift assay. Sodium Fluoride 176-179 interferon gamma Homo sapiens 111-120 7665948-7 1995 Follow up of patients 2 months, 4 months and 12 months after Praziquantel treatment showed that the level of IL-2 and IgE fell back to normal values after 4 months while IFN-gamma remained high, IL-2, IFN-gamma and IgE were raised once more after 12 months. Praziquantel 61-73 interferon gamma Homo sapiens 170-179 7634340-6 1995 PAF together with IFN-gamma stimulated macrophage secretion of NO2-. Nitrogen Dioxide 63-66 interferon gamma Homo sapiens 18-27 7634340-7 1995 In addition, PAF enhanced IFN-gamma- and LPS-stimulated NO2- production. Nitrogen Dioxide 56-59 interferon gamma Homo sapiens 26-35 7665948-7 1995 Follow up of patients 2 months, 4 months and 12 months after Praziquantel treatment showed that the level of IL-2 and IgE fell back to normal values after 4 months while IFN-gamma remained high, IL-2, IFN-gamma and IgE were raised once more after 12 months. Praziquantel 61-73 interferon gamma Homo sapiens 201-210 7643018-4 1995 Fc epsilon RII was also triggered by IFN-gamma, TNF-alpha, and IL-6 on all the cell lines, an effect blocked by calcitriol. Calcitriol 112-122 interferon gamma Homo sapiens 37-46 7643015-8 1995 In contrast, IL-12 induction of IFN-gamma cytoplasmic mRNA appears to only partially depend on activation of protein kinase C. Furthermore, both transforming growth factor-beta and genistein, a tyrosine kinase inhibitor, could suppress IL-2 and IL-12 signaling but CsA was generally inactive. Genistein 181-190 interferon gamma Homo sapiens 32-41 7643018-5 1995 On monocytes, the basal level and IFN-gamma-induced Fc gamma RI/CD64 expression was down-regulated by calcitriol and IL-4. Calcitriol 102-112 interferon gamma Homo sapiens 34-43 7643015-8 1995 In contrast, IL-12 induction of IFN-gamma cytoplasmic mRNA appears to only partially depend on activation of protein kinase C. Furthermore, both transforming growth factor-beta and genistein, a tyrosine kinase inhibitor, could suppress IL-2 and IL-12 signaling but CsA was generally inactive. Cyclosporine 265-268 interferon gamma Homo sapiens 32-41 7643018-2 1995 On both monocyte-derived macrophages and the myelomonocytic cell lines, Fc alpha R/CD89 expression was induced by calcitriol alone and additively in combination with tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and granulocyte-macrophage colony-stimulating factor. Calcitriol 114-124 interferon gamma Homo sapiens 207-223 7565811-3 1995 Treatment of U937 with IFN-gamma for 9 hr in the presence of cycloheximide led to super-induction of Fc gamma RI expression. Cycloheximide 61-74 interferon gamma Homo sapiens 23-32 7643018-2 1995 On both monocyte-derived macrophages and the myelomonocytic cell lines, Fc alpha R/CD89 expression was induced by calcitriol alone and additively in combination with tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and granulocyte-macrophage colony-stimulating factor. Calcitriol 114-124 interferon gamma Homo sapiens 225-234 7638755-13 1995 CONCLUSIONS: These results indicate that inhaled cyclosporine is effective therapy for refractory pulmonary rejection and that its mechanism of action is associated with suppression of proinflammatory cytokines IL-6 and interferon-gamma within the allograft. Cyclosporine 49-61 interferon gamma Homo sapiens 220-236 8578947-6 1995 Stimulation of normal human keratinocytes with either EGF-alpha or IFN-gamma resulted in an increase susceptibility to photodynamic therapy when 5-aminolevulinic acid was used. 5-amino levulinic acid 145-166 interferon gamma Homo sapiens 67-76 7615558-1 1995 Interferon gamma (IFN gamma) induces the expression of early response genes by tyrosine phosphorylation of Jak kinases and transcription factors referred to as STAT proteins. Tyrosine 79-87 interferon gamma Homo sapiens 0-16 7615558-1 1995 Interferon gamma (IFN gamma) induces the expression of early response genes by tyrosine phosphorylation of Jak kinases and transcription factors referred to as STAT proteins. Tyrosine 79-87 interferon gamma Homo sapiens 18-27 7615558-9 1995 IFN gamma clusters at least two receptor units which results in the tyrosine phosphorylation of Jak1 and Jak2, the activation of Jak2 kinase activity, and the recruitment of STAT1 alpha resulting in its activation by tyrosine phosphorylation. Tyrosine 68-76 interferon gamma Homo sapiens 0-9 7615558-9 1995 IFN gamma clusters at least two receptor units which results in the tyrosine phosphorylation of Jak1 and Jak2, the activation of Jak2 kinase activity, and the recruitment of STAT1 alpha resulting in its activation by tyrosine phosphorylation. Tyrosine 217-225 interferon gamma Homo sapiens 0-9 7669618-7 1995 Culture with indomethacin significantly enhanced OKT3-stimulated IFN-gamma production in both groups, whereas OKT3-stimulated IFN-gamma production was abolished with dibutyryl cAMP. Indomethacin 13-25 interferon gamma Homo sapiens 65-74 7669618-7 1995 Culture with indomethacin significantly enhanced OKT3-stimulated IFN-gamma production in both groups, whereas OKT3-stimulated IFN-gamma production was abolished with dibutyryl cAMP. Cyclic AMP 176-180 interferon gamma Homo sapiens 126-135 7669618-8 1995 IFN-gamma production was significantly lower with Ro 20-1742 in AD than in normal controls. ro 20-1742 50-60 interferon gamma Homo sapiens 0-9 7669618-10 1995 The addition of indomethacin increased IFN-gamma production in both groups, although the increase was less in AD patients, suggesting an intrinsic cellular defect. Indomethacin 16-28 interferon gamma Homo sapiens 39-48 7669618-11 1995 IFN-gamma release from AD MNL was more sensitive to the inhibitory effects of PDE, and this may be due to increased PDE activity, or the hyperdynamic cAMP system present in atopics. Cyclic AMP 150-154 interferon gamma Homo sapiens 0-9 7606802-5 1995 Preactivation of human monocytes with IFN-gamma led to subsequent increased IL-4- and CD23-driven nitrite and L-citrulline productions that were also suppressed in the presence of either nitro-L-arginine or the anti-CD23 mAb Fab fragment. Nitrites 98-105 interferon gamma Homo sapiens 38-47 7606802-5 1995 Preactivation of human monocytes with IFN-gamma led to subsequent increased IL-4- and CD23-driven nitrite and L-citrulline productions that were also suppressed in the presence of either nitro-L-arginine or the anti-CD23 mAb Fab fragment. Citrulline 110-122 interferon gamma Homo sapiens 38-47 7606802-5 1995 Preactivation of human monocytes with IFN-gamma led to subsequent increased IL-4- and CD23-driven nitrite and L-citrulline productions that were also suppressed in the presence of either nitro-L-arginine or the anti-CD23 mAb Fab fragment. Nitroarginine 187-203 interferon gamma Homo sapiens 38-47 7621585-6 1995 Preincubation of MC with human recombinant interferon-gamma (IFN-gamma) up-regulated MHC class II and intercellular adhesion molecule-1 (ICAM-1) expression, but the effect on antigen-presenting function was not consistent. Methylcholanthrene 17-19 interferon gamma Homo sapiens 43-59 7583919-4 1995 PMA at a concentration of 50 ng/ml plus 50 ng of calcium ionophore A23187 per ml was used to induce IFN-gamma, while 150 hemagglutinating units of Sendai virus was used to induce IFN-alpha production. Tetradecanoylphorbol Acetate 0-3 interferon gamma Homo sapiens 100-103 7583919-4 1995 PMA at a concentration of 50 ng/ml plus 50 ng of calcium ionophore A23187 per ml was used to induce IFN-gamma, while 150 hemagglutinating units of Sendai virus was used to induce IFN-alpha production. Calcimycin 67-73 interferon gamma Homo sapiens 100-103 7583919-7 1995 However, CBL produced significantly decreased levels of IFN-gamma compared with APBL in response to PMA plus ionophore. Vitamin B 12 9-12 interferon gamma Homo sapiens 56-59 7541323-0 1995 Nitric oxide mediates interferon-gamma-induced hyperpermeability in cultured human intestinal epithelial monolayers. Nitric Oxide 0-12 interferon gamma Homo sapiens 22-38 7621585-6 1995 Preincubation of MC with human recombinant interferon-gamma (IFN-gamma) up-regulated MHC class II and intercellular adhesion molecule-1 (ICAM-1) expression, but the effect on antigen-presenting function was not consistent. Methylcholanthrene 17-19 interferon gamma Homo sapiens 61-70 7541323-7 1995 MEASUREMENTS AND MAIN RESULTS: The permeability of monolayers to fluorescein sulfonic acid was significantly increased after incubation in the presence of interferon-gamma (250 to 1000 U/mL). fluorescein sulfonic acid 65-90 interferon gamma Homo sapiens 155-171 7628531-3 1995 Disruption of the actin cytoskeleton with dehydrocytochalasin B (CB) increased constitutive and potentiated INF gamma-induced ICAM-1 cell surface expression, but did not alter formation of soluble ICAM-1. dehydrocytochalasin B 42-63 interferon gamma Homo sapiens 108-117 7541323-9 1995 Concentrations of nitric oxide oxidation products, nitrite and nitrate, in incubation media were increased after exposure of cells to interferon-gamma. Nitric Oxide 18-30 interferon gamma Homo sapiens 134-150 7541323-9 1995 Concentrations of nitric oxide oxidation products, nitrite and nitrate, in incubation media were increased after exposure of cells to interferon-gamma. Nitrites 51-58 interferon gamma Homo sapiens 134-150 7541323-11 1995 CONCLUSIONS: These results suggest that upregulation of nitric oxide biosynthesis plays a pivotal role in the increase in permeability of intestinal epithelial (Caco-2BBe) monolayers induced by interferon-gamma. Nitric Oxide 56-68 interferon gamma Homo sapiens 194-210 7541323-12 1995 Increased production of nitric oxide induced by proinflammatory cytokines, such as interferon-gamma, may be an important factor contributing to gut mucosal hyperpermeability in sepsis. Nitric Oxide 24-36 interferon gamma Homo sapiens 83-99 7622767-2 1995 To examine the pattern of cytokine production associated with elevated IgE levels, phorbol ester plus ionomycin-stimulated production of interleukin (IL)-4, IL-5, and interferon-gamma (IFN-gamma) by blood mononuclear cells from 16 patients with atopic dermatitis was compared with that of 18 healthy subjects. Phorbol Esters 83-96 interferon gamma Homo sapiens 167-183 8530162-5 1995 TPA treatment also caused a profound change in the IFN-gamma activation of GAF and DIF. Tetradecanoylphorbol Acetate 0-3 interferon gamma Homo sapiens 51-60 7622767-2 1995 To examine the pattern of cytokine production associated with elevated IgE levels, phorbol ester plus ionomycin-stimulated production of interleukin (IL)-4, IL-5, and interferon-gamma (IFN-gamma) by blood mononuclear cells from 16 patients with atopic dermatitis was compared with that of 18 healthy subjects. Phorbol Esters 83-96 interferon gamma Homo sapiens 185-194 7622767-2 1995 To examine the pattern of cytokine production associated with elevated IgE levels, phorbol ester plus ionomycin-stimulated production of interleukin (IL)-4, IL-5, and interferon-gamma (IFN-gamma) by blood mononuclear cells from 16 patients with atopic dermatitis was compared with that of 18 healthy subjects. Ionomycin 102-111 interferon gamma Homo sapiens 167-183 7622767-2 1995 To examine the pattern of cytokine production associated with elevated IgE levels, phorbol ester plus ionomycin-stimulated production of interleukin (IL)-4, IL-5, and interferon-gamma (IFN-gamma) by blood mononuclear cells from 16 patients with atopic dermatitis was compared with that of 18 healthy subjects. Ionomycin 102-111 interferon gamma Homo sapiens 185-194 7622767-5 1995 Furthermore, ionomycin plus phorbol ester-stimulated mononuclear cells from patients with atopic dermatitis produced less IL-4 and more IFN-gamma than did cells from healthy subjects. Ionomycin 13-22 interferon gamma Homo sapiens 136-145 7622767-5 1995 Furthermore, ionomycin plus phorbol ester-stimulated mononuclear cells from patients with atopic dermatitis produced less IL-4 and more IFN-gamma than did cells from healthy subjects. Phorbol Esters 28-41 interferon gamma Homo sapiens 136-145 7541423-6 1995 Pretreatment of cells with the glucocorticoid budesonide (10(-10)-10(-7) M) for 24 h inhibited expression of RANTES mRNA and protein stimulated by either TNF-alpha or TNF-alpha plus IFN-gamma in a concentration- and time-dependent manner. Budesonide 46-56 interferon gamma Homo sapiens 182-191 7615820-0 1995 Inhibition of collagenase and stromelysin gene expression by interferon-gamma in human dermal fibroblasts is mediated in part via induction of tryptophan degradation. Tryptophan 143-153 interferon gamma Homo sapiens 61-77 7615820-5 1995 In addition, incubation of fibroblasts with IFN-gamma resulted in a marked increase in cellular indoleamine 2,3-dioxygenase (IDO) mRNA, a > 90% depletion of tryptophan, and a corresponding > 30-fold increase in the tryptophan metabolite kynurenine in the culture media. indolamine 96-107 interferon gamma Homo sapiens 44-53 7615820-5 1995 In addition, incubation of fibroblasts with IFN-gamma resulted in a marked increase in cellular indoleamine 2,3-dioxygenase (IDO) mRNA, a > 90% depletion of tryptophan, and a corresponding > 30-fold increase in the tryptophan metabolite kynurenine in the culture media. Tryptophan 160-170 interferon gamma Homo sapiens 44-53 7615975-4 1995 Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion. Tetradecanoylphorbol Acetate 69-94 interferon gamma Homo sapiens 265-318 7615820-5 1995 In addition, incubation of fibroblasts with IFN-gamma resulted in a marked increase in cellular indoleamine 2,3-dioxygenase (IDO) mRNA, a > 90% depletion of tryptophan, and a corresponding > 30-fold increase in the tryptophan metabolite kynurenine in the culture media. Tryptophan 221-231 interferon gamma Homo sapiens 44-53 7615820-5 1995 In addition, incubation of fibroblasts with IFN-gamma resulted in a marked increase in cellular indoleamine 2,3-dioxygenase (IDO) mRNA, a > 90% depletion of tryptophan, and a corresponding > 30-fold increase in the tryptophan metabolite kynurenine in the culture media. Kynurenine 243-253 interferon gamma Homo sapiens 44-53 7615820-7 1995 Addition of exogenous tryptophan (25-50 micrograms/ml) to cultures that had been tryptophan depleted by pretreatment with IFN-gamma for 48 h restored the fibroblast response to IL-1 beta or PMA, but had no effect on IFN-gamma-induced HLA-DR alpha chain mRNA expression. Tryptophan 22-32 interferon gamma Homo sapiens 122-131 7615820-7 1995 Addition of exogenous tryptophan (25-50 micrograms/ml) to cultures that had been tryptophan depleted by pretreatment with IFN-gamma for 48 h restored the fibroblast response to IL-1 beta or PMA, but had no effect on IFN-gamma-induced HLA-DR alpha chain mRNA expression. Tryptophan 22-32 interferon gamma Homo sapiens 216-225 7616108-3 1995 Priming of microglial cell cultures with interferon-gamma or tumor necrosis factor-alpha resulted in a dose- and time-dependent enhancement of O2- production. Superoxides 143-145 interferon gamma Homo sapiens 41-88 7541446-5 1995 Treatment with interferon-beta (IFN-beta), platelet-derived growth factor-AA, leukemia inhibitory factor, phorbol 12-myristate 13-acetate, and dibutyryl cyclic AMP stimulated phosphorylation of HSP27 moderately, while IFN-gamma, TNF-beta, basic fibroblast growth factor, epidermal growth factor, or fetal bovine serum did not significantly alter the level of HSP27 phosphorylation. Tetradecanoylphorbol Acetate 106-137 interferon gamma Homo sapiens 218-227 7615820-8 1995 These results indicate that inhibition of collagenase and stromelysin gene expression by IFN-gamma in fibroblasts is associated with activation of IDO and enhanced cellular tryptophan metabolism. Tryptophan 173-183 interferon gamma Homo sapiens 89-98 7615820-9 1995 Tryptophan degradation and ensuing tryptophan depletion may account, at least in part, for the inhibitory effect of IFN-gamma on metalloproteinase production in dermal fibroblasts. Tryptophan 0-10 interferon gamma Homo sapiens 116-125 7615820-9 1995 Tryptophan degradation and ensuing tryptophan depletion may account, at least in part, for the inhibitory effect of IFN-gamma on metalloproteinase production in dermal fibroblasts. Tryptophan 35-45 interferon gamma Homo sapiens 116-125 7541446-5 1995 Treatment with interferon-beta (IFN-beta), platelet-derived growth factor-AA, leukemia inhibitory factor, phorbol 12-myristate 13-acetate, and dibutyryl cyclic AMP stimulated phosphorylation of HSP27 moderately, while IFN-gamma, TNF-beta, basic fibroblast growth factor, epidermal growth factor, or fetal bovine serum did not significantly alter the level of HSP27 phosphorylation. Bucladesine 143-163 interferon gamma Homo sapiens 218-227 7791765-6 1995 Analysis of STAT1 phosphoamino acids and mapping of phosphopeptides showed an IFN-gamma-dependent increase in Ser phosphorylation in differentiated cells. Phosphoamino Acids 18-36 interferon gamma Homo sapiens 78-87 7616451-13 1995 In addition, once IFN-gamma is produced, it primes macrophages for tumor killing that in turn secrete neopterin. Neopterin 102-111 interferon gamma Homo sapiens 18-27 8963748-10 1995 Steroid hormones and cytokines (interleukin-1 alpha, -beta, tumor necrosis factor, interferon-gamma) have a major regulatory influence on protein secretion, including the secretion of immunoglobulin into the saliva. Steroids 0-16 interferon gamma Homo sapiens 83-99 7791765-6 1995 Analysis of STAT1 phosphoamino acids and mapping of phosphopeptides showed an IFN-gamma-dependent increase in Ser phosphorylation in differentiated cells. Serine 110-113 interferon gamma Homo sapiens 78-87 7791765-9 1995 Consistent with the importance of Ser phosphorylation for high-affinity binding to the IFN-gamma activation site sequence, phosphatase 2A treatment strongly reduced the formation of IFN-gamma activation site-GAF complexes in an electrophoretic mobility shift assay. Serine 34-37 interferon gamma Homo sapiens 87-96 7791765-9 1995 Consistent with the importance of Ser phosphorylation for high-affinity binding to the IFN-gamma activation site sequence, phosphatase 2A treatment strongly reduced the formation of IFN-gamma activation site-GAF complexes in an electrophoretic mobility shift assay. Serine 34-37 interferon gamma Homo sapiens 182-191 7782332-0 1995 Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. cyclo(tyrosyl-tyrosyl) 74-81 interferon gamma Homo sapiens 16-32 7782332-11 1995 When other cytokines that activate JAK2 were tested for the ability to stimulate the tyrosyl phosphorylation of IRS-1, stimulation was detected with interferon-gamma and leukemia inhibitory factor. cyclo(tyrosyl-tyrosyl) 85-92 interferon gamma Homo sapiens 149-165 9634799-0 1995 N-glycosylation of recombinant human interferon-gamma produced in different animal expression systems. Nitrogen 0-1 interferon gamma Homo sapiens 37-53 7774059-0 1995 Increased IL-2, IL-4 and interferon-gamma (IFN-gamma) in steroid-sensitive nephrotic syndrome. Steroids 57-64 interferon gamma Homo sapiens 25-41 7774059-0 1995 Increased IL-2, IL-4 and interferon-gamma (IFN-gamma) in steroid-sensitive nephrotic syndrome. Steroids 57-64 interferon gamma Homo sapiens 43-52 7796299-1 1995 Herein, we demonstrate that purified Stat1 binds to its tyrosine-phosphorylated docking site on the IFN gamma receptor alpha chain in a direct, specific, and reversible manner. Tyrosine 56-64 interferon gamma Homo sapiens 100-109 7538819-4 1995 We have also shown that ATP caused the lysis of human macrophages, and that treatment of cells with interferon gamma (IFN gamma) rendered macrophages significantly more sensitive to ATP than untreated cells. Adenosine Triphosphate 24-27 interferon gamma Homo sapiens 100-116 7538819-4 1995 We have also shown that ATP caused the lysis of human macrophages, and that treatment of cells with interferon gamma (IFN gamma) rendered macrophages significantly more sensitive to ATP than untreated cells. Adenosine Triphosphate 182-185 interferon gamma Homo sapiens 100-116 7538819-4 1995 We have also shown that ATP caused the lysis of human macrophages, and that treatment of cells with interferon gamma (IFN gamma) rendered macrophages significantly more sensitive to ATP than untreated cells. Adenosine Triphosphate 182-185 interferon gamma Homo sapiens 118-127 7796299-4 1995 Finally, we describe experiments that imply that the unidirectional release of activated Stat1 from the IFN gamma receptor reflects the preference of free tyrosine-phosphorylated Stat1 monomers to form high avidity reciprocal homodimers rather than reassociating with the receptor binding site. Tyrosine 155-163 interferon gamma Homo sapiens 104-113 7782931-5 1995 In addition, 1,25-(OH)2-D3 directly inhibits IFN-gamma secretion by Th1 clones while it has little effect on IL-4 secretion by Th2 clones. Calcitriol 13-26 interferon gamma Homo sapiens 45-54 7769319-0 1995 Elevated cellular immune responses and interferon-gamma release after long-term diethylcarbamazine treatment of patients with human lymphatic filariasis. Diethylcarbamazine 80-98 interferon gamma Homo sapiens 39-55 7769319-5 1995 Production of interferon (IFN)-gamma by BmA-stimulated mononuclear cells increased significantly after DEC treatment (geometric mean, 39.6-55.7 U/mL; P < .05), largely due to improved responses in elephantiasis patients and asymptomatic amicrofilaremics. bma 40-43 interferon gamma Homo sapiens 14-36 7782931-6 1995 The analogue, 1,25-(OH)2-16ene-D3, is 100-fold more potent than 1,25-(OH)2-D3 in inhibiting IFN-gamma secretion but also has little effect on IL-4 secretion. 1,25-dihydroxy-16-ene-vitamin D3 14-33 interferon gamma Homo sapiens 92-101 7782931-6 1995 The analogue, 1,25-(OH)2-16ene-D3, is 100-fold more potent than 1,25-(OH)2-D3 in inhibiting IFN-gamma secretion but also has little effect on IL-4 secretion. Calcitriol 64-77 interferon gamma Homo sapiens 92-101 7759501-3 1995 Here, we analyze the mechanisms responsible for the inhibition of IFN-gamma promoter activity by the glucocorticoid hormone dexamethasone. Dexamethasone 124-137 interferon gamma Homo sapiens 66-75 7768637-1 1995 Human ovarian carcinoma cells (2008 and its cisplatin-resistant sub-line 2008/C13*) were sensitized to cisplatin by treatment with human recombinant gamma interferon (IFN gamma). Cisplatin 44-53 interferon gamma Homo sapiens 149-176 7768637-1 1995 Human ovarian carcinoma cells (2008 and its cisplatin-resistant sub-line 2008/C13*) were sensitized to cisplatin by treatment with human recombinant gamma interferon (IFN gamma). Cisplatin 103-112 interferon gamma Homo sapiens 149-176 7768637-3 1995 Exposure of 2008 and 2008/C13* cells to IFN gamma resulted in a time-dependent decrease of cellular glutathione and total glutathione-S-transferase activity, principally the pi isoform. Glutathione 100-111 interferon gamma Homo sapiens 40-49 7759501-4 1995 Cotransfection assays performed in Jurkat T cells demonstrated that the activity of the initial 108 base pairs of the IFN-gamma promoter was down-regulated in the presence of dexamethasone. Dexamethasone 175-188 interferon gamma Homo sapiens 118-127 7759501-5 1995 Furthermore, utilizing electrophoretic mobility shift analysis, we identified activator protein 1 AP-1-cAMP response element binding protein-activating transcription factor (CREB-ATF) binding elements situated in positions of the IFN-gamma promoter previously identified as essential for promoter activity. Cyclic AMP 103-107 interferon gamma Homo sapiens 230-239 7743514-2 1995 Since IFN-gamma enhances effects mediated by retinoids more than vice versa, we focused our investigations on the mRNA expression of cellular retinoic acid-binding proteins (CRABPs) and retinoic acid receptors (RARs), since these are the key molecules that mediate retinoid action. Retinoids 45-54 interferon gamma Homo sapiens 6-15 7743514-7 1995 RA (1 microM)-mediated CRABP II increase was suppressed by IFN-gamma (10 ng/ml). Radium 0-2 interferon gamma Homo sapiens 59-68 7755594-10 1995 Whether the differential glycosylation of n- and recombinant IFN-gamma (rIFN-gamma) is reflected in their biological activities in tissues or their clinical applicability is not known. Nitrogen 19-20 interferon gamma Homo sapiens 61-70 7755594-0 1995 N-glycosylation of human interferon-gamma: glycans at Asn-25 are critical for protease resistance. Nitrogen 0-1 interferon gamma Homo sapiens 25-41 7755594-0 1995 N-glycosylation of human interferon-gamma: glycans at Asn-25 are critical for protease resistance. Polysaccharides 43-50 interferon gamma Homo sapiens 25-41 7747803-4 1995 Immunohistochemical staining and flow cytometry analysis revealed that normal cultured keratinocytes express low levels of Fas, CD40, and Bcl-x that was enhanced by cytokines including gamma-interferon (IFN-gamma) and a phorbol ester tumor promoter, TPA. Tetradecanoylphorbol Acetate 250-253 interferon gamma Homo sapiens 203-212 7755594-0 1995 N-glycosylation of human interferon-gamma: glycans at Asn-25 are critical for protease resistance. Asparagine 54-57 interferon gamma Homo sapiens 25-41 7755594-1 1995 Human interferon-gamma (IFN-gamma) is a secretory, dimeric glycoprotein that forms a compact globular structure with potential N-linked glycosylation sites at Asn-25 and Asn-97 on the surface of the dimer. Nitrogen 26-27 interferon gamma Homo sapiens 6-22 7755594-1 1995 Human interferon-gamma (IFN-gamma) is a secretory, dimeric glycoprotein that forms a compact globular structure with potential N-linked glycosylation sites at Asn-25 and Asn-97 on the surface of the dimer. Asparagine 159-162 interferon gamma Homo sapiens 6-22 7755594-1 1995 Human interferon-gamma (IFN-gamma) is a secretory, dimeric glycoprotein that forms a compact globular structure with potential N-linked glycosylation sites at Asn-25 and Asn-97 on the surface of the dimer. Asparagine 159-162 interferon gamma Homo sapiens 24-33 7755594-1 1995 Human interferon-gamma (IFN-gamma) is a secretory, dimeric glycoprotein that forms a compact globular structure with potential N-linked glycosylation sites at Asn-25 and Asn-97 on the surface of the dimer. Asparagine 170-173 interferon gamma Homo sapiens 6-22 7755594-1 1995 Human interferon-gamma (IFN-gamma) is a secretory, dimeric glycoprotein that forms a compact globular structure with potential N-linked glycosylation sites at Asn-25 and Asn-97 on the surface of the dimer. Asparagine 170-173 interferon gamma Homo sapiens 24-33 7755594-6 1995 The glycan residues of IFN-gamma, especially at Asn-25, play an important role in protease resistance. Polysaccharides 4-10 interferon gamma Homo sapiens 23-32 7755594-6 1995 The glycan residues of IFN-gamma, especially at Asn-25, play an important role in protease resistance. Asparagine 48-51 interferon gamma Homo sapiens 23-32 7755594-9 1995 These results emphasize the importance of glycan residues, especially at Asn-25, in the proteolytic stability of human IFN-gamma. Polysaccharides 42-48 interferon gamma Homo sapiens 119-128 7755594-9 1995 These results emphasize the importance of glycan residues, especially at Asn-25, in the proteolytic stability of human IFN-gamma. Asparagine 73-76 interferon gamma Homo sapiens 119-128 7755064-14 1995 CONCLUSIONS: Our data suggest that interferon gamma affects granulosa cell steroid production both independently and in synergy with associated white blood cells and further supports the hypothesis that interferon gamma may be an important intraovarian regulator of ovarian steroid production during the luteal phase. Steroids 274-281 interferon gamma Homo sapiens 35-51 7755064-14 1995 CONCLUSIONS: Our data suggest that interferon gamma affects granulosa cell steroid production both independently and in synergy with associated white blood cells and further supports the hypothesis that interferon gamma may be an important intraovarian regulator of ovarian steroid production during the luteal phase. Steroids 274-281 interferon gamma Homo sapiens 203-219 7755064-0 1995 Interferon gamma inhibits luteinized human granulosa cell steroid production in vitro. Steroids 58-65 interferon gamma Homo sapiens 0-16 7755064-1 1995 OBJECTIVE: The purpose of this study was to determine whether interferon gamma affects luteinized human granulosa cell progesterone, estrone, and estradiol production in the presence and absence of associated white blood cells by either cytotoxic or antiproliferative mechanisms. Progesterone 119-131 interferon gamma Homo sapiens 62-78 7755064-1 1995 OBJECTIVE: The purpose of this study was to determine whether interferon gamma affects luteinized human granulosa cell progesterone, estrone, and estradiol production in the presence and absence of associated white blood cells by either cytotoxic or antiproliferative mechanisms. Estrone 133-140 interferon gamma Homo sapiens 62-78 7755064-1 1995 OBJECTIVE: The purpose of this study was to determine whether interferon gamma affects luteinized human granulosa cell progesterone, estrone, and estradiol production in the presence and absence of associated white blood cells by either cytotoxic or antiproliferative mechanisms. Estradiol 146-155 interferon gamma Homo sapiens 62-78 7755064-7 1995 RESULTS: Interferon gamma significantly inhibited granulosa cell progesterone production in both basal and human chorionic gonadotropin-stimulated cells cocultured with white blood cells in a concentration-dependent manner, whereas cells cultured free of white blood cells demonstrated less inhibition. Progesterone 65-77 interferon gamma Homo sapiens 9-25 7755064-9 1995 Interferon gamma inhibited granulosa cell estrone and estradiol production in basal cultures containing white blood cells in both a time- and concentration-dependent manner. Estradiol 54-63 interferon gamma Homo sapiens 0-16 7755064-11 1995 Both estrone and estradiol synthesis were inhibited by 50 ng/ml interferon gamma in granulosa cell cultures free of white blood cells. Estrone 5-12 interferon gamma Homo sapiens 64-80 7755064-11 1995 Both estrone and estradiol synthesis were inhibited by 50 ng/ml interferon gamma in granulosa cell cultures free of white blood cells. Estradiol 17-26 interferon gamma Homo sapiens 64-80 7755064-14 1995 CONCLUSIONS: Our data suggest that interferon gamma affects granulosa cell steroid production both independently and in synergy with associated white blood cells and further supports the hypothesis that interferon gamma may be an important intraovarian regulator of ovarian steroid production during the luteal phase. Steroids 75-82 interferon gamma Homo sapiens 35-51 7755064-14 1995 CONCLUSIONS: Our data suggest that interferon gamma affects granulosa cell steroid production both independently and in synergy with associated white blood cells and further supports the hypothesis that interferon gamma may be an important intraovarian regulator of ovarian steroid production during the luteal phase. Steroids 75-82 interferon gamma Homo sapiens 203-219 7545487-1 1995 Cyclosporin A (CsA) inhibited interleukin 2 (IL-2), IL-3, interferon gamma (IFN gamma), GM-CSF and tumor necrosis factor alpha (TNF alpha) mRNA expression in spleen cells stimulated with concavalin A (Con A) when determined by the semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) method. Cyclosporine 0-13 interferon gamma Homo sapiens 58-74 7545487-1 1995 Cyclosporin A (CsA) inhibited interleukin 2 (IL-2), IL-3, interferon gamma (IFN gamma), GM-CSF and tumor necrosis factor alpha (TNF alpha) mRNA expression in spleen cells stimulated with concavalin A (Con A) when determined by the semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) method. Cyclosporine 0-13 interferon gamma Homo sapiens 76-85 7545487-1 1995 Cyclosporin A (CsA) inhibited interleukin 2 (IL-2), IL-3, interferon gamma (IFN gamma), GM-CSF and tumor necrosis factor alpha (TNF alpha) mRNA expression in spleen cells stimulated with concavalin A (Con A) when determined by the semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) method. Cyclosporine 15-18 interferon gamma Homo sapiens 58-74 7545487-1 1995 Cyclosporin A (CsA) inhibited interleukin 2 (IL-2), IL-3, interferon gamma (IFN gamma), GM-CSF and tumor necrosis factor alpha (TNF alpha) mRNA expression in spleen cells stimulated with concavalin A (Con A) when determined by the semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) method. Cyclosporine 15-18 interferon gamma Homo sapiens 76-85 7664177-1 1995 In a number of mammalian cell types, pteridine biosynthesis from guanosine 5"-triphosphate and formation of nitric oxide from L-arginine are induced by gamma interferon (IFN-gamma) and bacterial lipopolysaccharide (LPS). Pteridines 37-46 interferon gamma Homo sapiens 152-179 7664177-1 1995 In a number of mammalian cell types, pteridine biosynthesis from guanosine 5"-triphosphate and formation of nitric oxide from L-arginine are induced by gamma interferon (IFN-gamma) and bacterial lipopolysaccharide (LPS). Guanosine Triphosphate 65-90 interferon gamma Homo sapiens 152-179 7664177-1 1995 In a number of mammalian cell types, pteridine biosynthesis from guanosine 5"-triphosphate and formation of nitric oxide from L-arginine are induced by gamma interferon (IFN-gamma) and bacterial lipopolysaccharide (LPS). Nitric Oxide 108-120 interferon gamma Homo sapiens 152-179 7743662-4 1995 LMP-induced interferon-gamma (IFN-gamma) production was lower in patients with severe than in patients with mild disease (P < 0.05). (2~{s},3~{r},4~{s})-2-[(2~{s},3~{r})-1,3-Bis(Oxidanyl)-1-Oxidanylidene-Butan-2-Yl]-4-[(3~{s},5~{s})-5-(Dimethylcarbamoyl)pyrrolidin-3-Yl]sulfanyl-3-Methyl-3,4-Dihydro-2~{h}-Pyrrole-5-Carboxylic Acid 0-3 interferon gamma Homo sapiens 12-28 7743662-4 1995 LMP-induced interferon-gamma (IFN-gamma) production was lower in patients with severe than in patients with mild disease (P < 0.05). (2~{s},3~{r},4~{s})-2-[(2~{s},3~{r})-1,3-Bis(Oxidanyl)-1-Oxidanylidene-Butan-2-Yl]-4-[(3~{s},5~{s})-5-(Dimethylcarbamoyl)pyrrolidin-3-Yl]sulfanyl-3-Methyl-3,4-Dihydro-2~{h}-Pyrrole-5-Carboxylic Acid 0-3 interferon gamma Homo sapiens 30-39 7664177-1 1995 In a number of mammalian cell types, pteridine biosynthesis from guanosine 5"-triphosphate and formation of nitric oxide from L-arginine are induced by gamma interferon (IFN-gamma) and bacterial lipopolysaccharide (LPS). Arginine 126-136 interferon gamma Homo sapiens 152-179 7537250-7 1995 The addition of exogenous tryptophan reversed the effect of combined IFN and IL-1 treatment, indicating that IDO activity induced by combined cytokine treatment was responsible for chlamydial inhibition. Tryptophan 26-36 interferon gamma Homo sapiens 69-72 7745015-5 1995 Both IFN gamma and IL-1 beta inhibited [3H]thymidine incorporation into TP cells in a dose-dependent manner and decreased TP cell number. Tritium 40-42 interferon gamma Homo sapiens 5-14 7613170-5 1995 IFN-gamma was produced following all three stimuli, but was greatest from cells cultured with PMA and ionomycin. Tetradecanoylphorbol Acetate 94-97 interferon gamma Homo sapiens 0-9 7613170-5 1995 IFN-gamma was produced following all three stimuli, but was greatest from cells cultured with PMA and ionomycin. Ionomycin 102-111 interferon gamma Homo sapiens 0-9 7636320-5 1995 Furthermore, indomethacin augmented the production of IFN gamma from stimulated BMNC both in the hyperthermic and the control experiments; the indomethacin effect was, however, not different at the two conditions. Indomethacin 13-25 interferon gamma Homo sapiens 54-63 7745015-6 1995 In NP cells, treatment with IFN gamma and IL-1 beta also decreased [3H]thymidine incorporation and cell number. Tritium 68-70 interferon gamma Homo sapiens 28-37 7745015-5 1995 Both IFN gamma and IL-1 beta inhibited [3H]thymidine incorporation into TP cells in a dose-dependent manner and decreased TP cell number. Thymidine 43-52 interferon gamma Homo sapiens 5-14 7745015-6 1995 In NP cells, treatment with IFN gamma and IL-1 beta also decreased [3H]thymidine incorporation and cell number. Thymidine 71-80 interferon gamma Homo sapiens 28-37 7745958-8 1995 Using hydroxyproline as an index for collagen production, a 34% reduction (P < 0.05) in collagen synthesis was observed in HTS fibroblast culture media after treatment with IFN-gamma (1000 u/ml) for 48 hr. Hydroxyproline 6-20 interferon gamma Homo sapiens 176-185 7738361-0 1995 Inhibition of interferon-gamma-induced intercellular adhesion molecule-1 expression on human keratinocytes by phosphorothioate antisense oligodeoxynucleotides is the consequence of antisense-specific and antisense-non-specific effects. Parathion 110-126 interferon gamma Homo sapiens 14-30 7738361-0 1995 Inhibition of interferon-gamma-induced intercellular adhesion molecule-1 expression on human keratinocytes by phosphorothioate antisense oligodeoxynucleotides is the consequence of antisense-specific and antisense-non-specific effects. Oligodeoxyribonucleotides 137-158 interferon gamma Homo sapiens 14-30 7537975-5 1995 However, in cells differentiated with 1,25-D3 plus IFN-gamma, prior enrichment with all three PUFA slightly but significantly (P < 0.05) increased the expression of the monocytic surface antigens CD11b and CD14 and generation of superoxide anion. Superoxides 232-248 interferon gamma Homo sapiens 51-60 18623274-8 1995 Thus, live cells producing IFN-gamma are heterogeneous in their environment, with variable access to O(2) and nutrients. o(2) 101-105 interferon gamma Homo sapiens 27-36 7535209-0 1995 Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate. Tyrosine 0-8 interferon gamma Homo sapiens 48-64 7715705-4 1995 Here we report a synergistic effect between A beta and interferon-gamma (IFN-gamma) in triggering the production of reactive nitrogen intermediates and tumour-necrosis factor-alpha (TNF-alpha) from microglia. Nitrogen 125-133 interferon gamma Homo sapiens 55-71 7715705-4 1995 Here we report a synergistic effect between A beta and interferon-gamma (IFN-gamma) in triggering the production of reactive nitrogen intermediates and tumour-necrosis factor-alpha (TNF-alpha) from microglia. Nitrogen 125-133 interferon gamma Homo sapiens 73-82 7715705-6 1995 These findings suggest that A beta and IFN-gamma activate microglia to produce reactive nitrogen intermediates and TNF-alpha, and this may have a role in the pathogenesis of neuronal degeneration observed in ageing and Alzheimer"s disease. Nitrogen 88-96 interferon gamma Homo sapiens 39-48 7600375-4 1995 Salbutamol and fenoterol inhibited interferon-(IFN)-gamma production by PHA-activated human PBMC suggesting that the blockade of the production of this cytokine could possibly explain the enhancement of IgE production. Albuterol 0-10 interferon gamma Homo sapiens 35-57 7600375-4 1995 Salbutamol and fenoterol inhibited interferon-(IFN)-gamma production by PHA-activated human PBMC suggesting that the blockade of the production of this cytokine could possibly explain the enhancement of IgE production. Fenoterol 15-24 interferon gamma Homo sapiens 35-57 7535209-0 1995 Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate. Tyrosine 0-8 interferon gamma Homo sapiens 66-75 7535209-0 1995 Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate. Sodium orthovanadate 99-120 interferon gamma Homo sapiens 48-64 7535209-0 1995 Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate. Sodium orthovanadate 99-120 interferon gamma Homo sapiens 66-75 7535209-2 1995 We describe here how treatment of activated cultures of peripheral blood mononuclear cells (PBMC) with the phosphotyrosine phosphatases (PTP) inhibitor sodium ortho vanadate results in greatly enhanced IFN-gamma production. Vanadates 165-173 interferon gamma Homo sapiens 202-211 7535209-4 1995 Increased IFN-gamma production, but not inhibition of cellular proliferation, was also observed in mitogen-activated vanadate-treated Jurkat cells. Vanadates 117-125 interferon gamma Homo sapiens 10-19 7535209-5 1995 On the other hand, IFN-gamma production induced in cultures of PBMC treated or not with vanadate, was strongly inhibited by incubation with the protein tyrosine kinase (PTK) inhibitor herbimycin A. Vanadates 88-96 interferon gamma Homo sapiens 19-28 7535209-5 1995 On the other hand, IFN-gamma production induced in cultures of PBMC treated or not with vanadate, was strongly inhibited by incubation with the protein tyrosine kinase (PTK) inhibitor herbimycin A. herbimycin 184-196 interferon gamma Homo sapiens 19-28 7535209-7 1995 We suggest that the tyrosine phosphorylation pathway plays a role in regulating IFN-gamma production. Tyrosine 20-28 interferon gamma Homo sapiens 80-89 7737290-3 1995 We describe that ionomycin induced IFN-gamma gene transcription, which was totally inhibited in the presence of cyclosporin A (CSA), an immunosuppressant forming a calcineurin-inhibiting complex with cyclophilin. Ionomycin 17-26 interferon gamma Homo sapiens 35-44 7737290-0 1995 Regulation of interferon-gamma mRNA in a cytolytic T cell clone: Ca(2+)-induced transcription followed by mRNA stabilization through activation of protein kinase C or increase in cAMP. Cyclic AMP 179-183 interferon gamma Homo sapiens 14-30 7737290-6 1995 When transcription of the IFN-gamma gene, initiated in the presence of ionomycin and an agent increasing intracellular cAMP, was inhibited by CSA in the absence of PKC or cAMP-dependent protein kinase activation, the IFN-gamma mRNA was rapidly degraded (half-life = 30 min). Ionomycin 71-80 interferon gamma Homo sapiens 26-35 7737290-2 1995 IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein kinase C (PKC)-activating phorbol 12-myristate 13-acetate (PMA) or with agents increasing cAMP, including prostaglandin E2. Ionomycin 74-83 interferon gamma Homo sapiens 0-9 7737290-2 1995 IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein kinase C (PKC)-activating phorbol 12-myristate 13-acetate (PMA) or with agents increasing cAMP, including prostaglandin E2. Tetradecanoylphorbol Acetate 155-186 interferon gamma Homo sapiens 0-9 7737290-2 1995 IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein kinase C (PKC)-activating phorbol 12-myristate 13-acetate (PMA) or with agents increasing cAMP, including prostaglandin E2. Tetradecanoylphorbol Acetate 188-191 interferon gamma Homo sapiens 0-9 7737290-2 1995 IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein kinase C (PKC)-activating phorbol 12-myristate 13-acetate (PMA) or with agents increasing cAMP, including prostaglandin E2. Cyclic AMP 219-223 interferon gamma Homo sapiens 0-9 7737290-2 1995 IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein kinase C (PKC)-activating phorbol 12-myristate 13-acetate (PMA) or with agents increasing cAMP, including prostaglandin E2. Dinoprostone 235-251 interferon gamma Homo sapiens 0-9 7737290-6 1995 When transcription of the IFN-gamma gene, initiated in the presence of ionomycin and an agent increasing intracellular cAMP, was inhibited by CSA in the absence of PKC or cAMP-dependent protein kinase activation, the IFN-gamma mRNA was rapidly degraded (half-life = 30 min). Ionomycin 71-80 interferon gamma Homo sapiens 217-226 7737290-6 1995 When transcription of the IFN-gamma gene, initiated in the presence of ionomycin and an agent increasing intracellular cAMP, was inhibited by CSA in the absence of PKC or cAMP-dependent protein kinase activation, the IFN-gamma mRNA was rapidly degraded (half-life = 30 min). Cyclic AMP 119-123 interferon gamma Homo sapiens 26-35 7737290-7 1995 When either PKC was activated or intracellular cAMP was increased at the time of inhibition with CSA, a stabilizing effect was observed on IFN-gamma mRNA, which led to an increase in secreted IFN-gamma. Cyclic AMP 47-51 interferon gamma Homo sapiens 139-148 7737290-7 1995 When either PKC was activated or intracellular cAMP was increased at the time of inhibition with CSA, a stabilizing effect was observed on IFN-gamma mRNA, which led to an increase in secreted IFN-gamma. Cyclic AMP 47-51 interferon gamma Homo sapiens 192-201 7553049-3 1995 They also efficiently inhibited the production of O2- by both unstimulated and IFN-gamma-activated human monocytes. Superoxides 50-52 interferon gamma Homo sapiens 79-88 21556599-5 1995 Most of the cell lines that were sensitive to anti-Pas antibody showed evidence of enhanced apoptosis when the cells were pretreated with interferon-gamma. Protactinium 51-54 interferon gamma Homo sapiens 138-154 7553049-5 1995 Moreover, the production of O2- and NO was effectively suppressed whether the IL-10 was added before or together with the stimulus, indicating that this cytokine acts primarily at an early stage of monocyte/macrophage activation by IFN-gamma and LPS. Superoxides 28-30 interferon gamma Homo sapiens 232-241 7553050-5 1995 We examined the effect of recombinant human interferon gamma (rh-IFN-gamma) and granulocyte colony stimulating factor (G-CSF) on CL of EB-LCL in vitro. eb-lcl 135-141 interferon gamma Homo sapiens 44-74 7763006-4 1995 Analysis of cellular inducible pathways demonstrated that RA augmented levels of gene expression: (i) induced by IFN-alpha such as 2"-5"-oligoadenylate synthetase, mRNA 561 and mRNA 6-16; (ii) induced by IFN-gamma such as 2A and P56; and (iii) induced by both IFN-alpha and IFN-gamma such as mRNA 1-8. Tretinoin 58-60 interferon gamma Homo sapiens 204-213 7722417-8 1995 IFN-gamma activation enhanced superoxide anion generation by D3-treated HL-60 cells but not by OCT-treated HL-60 cells, suggesting that the inhibition of L. pneumophila multiplication in IFN-gamma-activated cells is independent of superoxide generation. Superoxides 30-46 interferon gamma Homo sapiens 0-9 7722417-8 1995 IFN-gamma activation enhanced superoxide anion generation by D3-treated HL-60 cells but not by OCT-treated HL-60 cells, suggesting that the inhibition of L. pneumophila multiplication in IFN-gamma-activated cells is independent of superoxide generation. Superoxides 30-46 interferon gamma Homo sapiens 187-196 7722417-8 1995 IFN-gamma activation enhanced superoxide anion generation by D3-treated HL-60 cells but not by OCT-treated HL-60 cells, suggesting that the inhibition of L. pneumophila multiplication in IFN-gamma-activated cells is independent of superoxide generation. Superoxides 30-40 interferon gamma Homo sapiens 0-9 7763006-4 1995 Analysis of cellular inducible pathways demonstrated that RA augmented levels of gene expression: (i) induced by IFN-alpha such as 2"-5"-oligoadenylate synthetase, mRNA 561 and mRNA 6-16; (ii) induced by IFN-gamma such as 2A and P56; and (iii) induced by both IFN-alpha and IFN-gamma such as mRNA 1-8. Tretinoin 58-60 interferon gamma Homo sapiens 274-283 7763006-6 1995 Co-treatment of NB-4 cells by IFN-gamma plus RA induced a sub-set of IFN-induced genes which were not induced by either IFN-gamma or RA alone. Tretinoin 45-47 interferon gamma Homo sapiens 120-129 7774202-0 1995 In vitro release of interferon-gamma by peripheral blood mononuclear cells of a patient with carbamazepine-induced allergic drug eruption in response to stimulation with carbamazepine. Carbamazepine 93-106 interferon gamma Homo sapiens 20-36 7538426-0 1995 Lipoprotein lipase synergizes with interferon gamma to induce macrophage nitric oxide synthetase mRNA expression and nitric oxide production. nitric 73-79 interferon gamma Homo sapiens 35-51 7538426-0 1995 Lipoprotein lipase synergizes with interferon gamma to induce macrophage nitric oxide synthetase mRNA expression and nitric oxide production. Nitric Oxide 73-85 interferon gamma Homo sapiens 35-51 7538426-2 1995 Since TNF-alpha can increase interferon gamma (IFN-gamma)-dependent nitric oxide (NO) production, we studied whether LPL may synergize with IFN-gamma for the induction of macrophage NO production. Nitric Oxide 68-80 interferon gamma Homo sapiens 29-56 7538426-2 1995 Since TNF-alpha can increase interferon gamma (IFN-gamma)-dependent nitric oxide (NO) production, we studied whether LPL may synergize with IFN-gamma for the induction of macrophage NO production. Nitric Oxide 68-80 interferon gamma Homo sapiens 47-56 7538426-3 1995 Although ineffective by itself, LPL in combination with IFN-gamma increased L-arginine-dependent NO production in a dose-dependent manner. Arginine 76-86 interferon gamma Homo sapiens 56-65 7774202-0 1995 In vitro release of interferon-gamma by peripheral blood mononuclear cells of a patient with carbamazepine-induced allergic drug eruption in response to stimulation with carbamazepine. Carbamazepine 170-183 interferon gamma Homo sapiens 20-36 7705397-0 1995 Heparin inhibits the antiparasitic and immune modulatory effects of human recombinant interferon-gamma. Heparin 0-7 interferon gamma Homo sapiens 86-102 7728396-7 1995 These findings suggest that the perpetuation of chronic inflammation of pSS may be due to the induction of HLA-DR and La antigen expression on epithelial cells by IFN-gamma. pss 72-75 interferon gamma Homo sapiens 163-172 7790043-5 1995 The activity of IDO can be induced by cytokines such as IFN-gamma, and therefore low Trp levels may result from endogenous IFN-gamma production due to immune activation against tumors. Tryptophan 85-88 interferon gamma Homo sapiens 123-132 7768980-4 1995 Of the compounds tested, three antagonists of calmodulin-linked pathways (trifluoperazine, KN-62, and calmidazolium) blocked the ATP-mediated lysis of both interferon-gamma-treated and colony-stimulating factor-treated macrophages in a dose-dependent manner. Trifluoperazine 74-89 interferon gamma Homo sapiens 156-172 7768980-4 1995 Of the compounds tested, three antagonists of calmodulin-linked pathways (trifluoperazine, KN-62, and calmidazolium) blocked the ATP-mediated lysis of both interferon-gamma-treated and colony-stimulating factor-treated macrophages in a dose-dependent manner. KN 62 91-96 interferon gamma Homo sapiens 156-172 7768980-4 1995 Of the compounds tested, three antagonists of calmodulin-linked pathways (trifluoperazine, KN-62, and calmidazolium) blocked the ATP-mediated lysis of both interferon-gamma-treated and colony-stimulating factor-treated macrophages in a dose-dependent manner. calmidazolium 102-115 interferon gamma Homo sapiens 156-172 7768980-4 1995 Of the compounds tested, three antagonists of calmodulin-linked pathways (trifluoperazine, KN-62, and calmidazolium) blocked the ATP-mediated lysis of both interferon-gamma-treated and colony-stimulating factor-treated macrophages in a dose-dependent manner. Adenosine Triphosphate 129-132 interferon gamma Homo sapiens 156-172 7705397-3 1995 Furthermore, it has been shown that IFN-gamma binds with a great affinity to the heparin-like structure of heparan sulfate, which is localized in basement membranes and on cell surfaces. Heparin 81-88 interferon gamma Homo sapiens 36-45 7705397-3 1995 Furthermore, it has been shown that IFN-gamma binds with a great affinity to the heparin-like structure of heparan sulfate, which is localized in basement membranes and on cell surfaces. Heparitin Sulfate 107-122 interferon gamma Homo sapiens 36-45 7860649-7 1995 Finally, the association of interferon (IFN gamma) with TNF alpha and/or glucagon was unable to modify the transport activity. Glucagon 73-81 interferon gamma Homo sapiens 40-49 7705397-4 1995 In this study, we analyze the effect of heparin and heparan sulfate on three different IFN-gamma-mediated activities inducible in human glioblastoma cells (87HG31 and 86HG39). Heparin 40-47 interferon gamma Homo sapiens 87-96 7705397-4 1995 In this study, we analyze the effect of heparin and heparan sulfate on three different IFN-gamma-mediated activities inducible in human glioblastoma cells (87HG31 and 86HG39). Heparitin Sulfate 52-67 interferon gamma Homo sapiens 87-96 7705397-5 1995 We find firstly that heparin is able to inhibit IFN-gamma-mediated induction of major histocompatibility complex (MHC) class II antigen expression on 87HG31 cells, an effect which can be abrogated by protamine. Heparin 21-28 interferon gamma Homo sapiens 48-57 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Heparin 23-30 interferon gamma Homo sapiens 44-53 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Heparin 23-30 interferon gamma Homo sapiens 166-175 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Heparin 145-152 interferon gamma Homo sapiens 44-53 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Heparin 145-152 interferon gamma Homo sapiens 166-175 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Tryptophan 202-212 interferon gamma Homo sapiens 44-53 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Tryptophan 202-212 interferon gamma Homo sapiens 166-175 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. indolamine 230-241 interferon gamma Homo sapiens 44-53 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. indolamine 230-241 interferon gamma Homo sapiens 166-175 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. 3-dioxygenase 244-257 interferon gamma Homo sapiens 44-53 7705397-6 1995 Secondly, we show that heparin inhibits the IFN-gamma-induced toxoplasmostasis within 86HG39 cells in a dose-dependent fashion, and thirdly that heparin inhibits the IFN-gamma-mediated induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. 3-dioxygenase 244-257 interferon gamma Homo sapiens 166-175 7705397-8 1995 The possible mechanism of heparin-induced inhibition of IFN-gamma is discussed. Heparin 26-33 interferon gamma Homo sapiens 56-65 7534807-5 1995 Incubation of washed platelets in Ca(++)-free buffer with cytokines (tumor necrosis factor-alpha and interferon-gamma) or cytokines plus lipopolysaccharide caused a marked increase in the conversion of [3H]L-arginine to [3H]L-citrulline, suggesting the presence of inducible form of NO synthase. Tritium 203-205 interferon gamma Homo sapiens 101-117 7533818-0 1995 Retinoic acid inhibits basal and interferon-gamma-induced expression of intercellular adhesion molecule 1 in monocytic cells. Tretinoin 0-13 interferon gamma Homo sapiens 33-49 7533818-5 1995 In contrast, suppression of IFN-gamma-induced ICAM-1 expression by RA was only partly reversible by indomethacin, suggesting that inhibition of IFN-gamma stimulation was not completely due to cyclooxygenase induction. Tretinoin 67-69 interferon gamma Homo sapiens 28-37 7533818-5 1995 In contrast, suppression of IFN-gamma-induced ICAM-1 expression by RA was only partly reversible by indomethacin, suggesting that inhibition of IFN-gamma stimulation was not completely due to cyclooxygenase induction. Indomethacin 100-112 interferon gamma Homo sapiens 28-37 7534807-5 1995 Incubation of washed platelets in Ca(++)-free buffer with cytokines (tumor necrosis factor-alpha and interferon-gamma) or cytokines plus lipopolysaccharide caused a marked increase in the conversion of [3H]L-arginine to [3H]L-citrulline, suggesting the presence of inducible form of NO synthase. Arginine 206-216 interferon gamma Homo sapiens 101-117 7533818-8 1995 RA also blocked ICAM-1 induction by IFN-gamma in isolated human blood monocytes. Tretinoin 0-2 interferon gamma Homo sapiens 36-45 7534807-5 1995 Incubation of washed platelets in Ca(++)-free buffer with cytokines (tumor necrosis factor-alpha and interferon-gamma) or cytokines plus lipopolysaccharide caused a marked increase in the conversion of [3H]L-arginine to [3H]L-citrulline, suggesting the presence of inducible form of NO synthase. Tritium 221-223 interferon gamma Homo sapiens 101-117 7534807-5 1995 Incubation of washed platelets in Ca(++)-free buffer with cytokines (tumor necrosis factor-alpha and interferon-gamma) or cytokines plus lipopolysaccharide caused a marked increase in the conversion of [3H]L-arginine to [3H]L-citrulline, suggesting the presence of inducible form of NO synthase. Citrulline 224-236 interferon gamma Homo sapiens 101-117 7585041-3 1995 Here, we report that rolipram, a selective type IV phosphodiesterase inhibitor, stereospecifically suppresses the production of TNF/LT and less strongly also IFN-gamma in human and rat auto-reactive T cells. Rolipram 21-29 interferon gamma Homo sapiens 158-167 7884317-6 1995 The anti-inflammatory agent, dexamethasone, was the most potent agent in controlling the SE-mediated effects as evidenced by inhibited T cell proliferation (55%) and reduced levels of IL-1, IL-6, and IFN gamma (60% to 100%) and TNF alpha (50%). Dexamethasone 29-42 interferon gamma Homo sapiens 200-209 7884317-7 1995 Reducing levels of toxic mediators such as TNF alpha, IL-1, IL-6, and IFN gamma by dexamethasone in SE-induced T cell responses may be a useful therapeutic strategy to circumvent SE toxicity and pathogenesis. Dexamethasone 83-96 interferon gamma Homo sapiens 70-79 7875295-8 1995 A 112 kDa protein could be isolated from either GM-CSF- or IFN-gamma-treated cells by GAS oligonucleotide precipitation. Oligonucleotides 90-105 interferon gamma Homo sapiens 59-68 7871387-5 1995 Furthermore, a higher number of IFN-gamma producing cells was found after immunization with PPS-14-CRM197, as compared with immunization with PPS-14. Pentosan Sulfuric Polyester 92-95 interferon gamma Homo sapiens 32-41 7757220-0 1995 Study of conformational effects of recombinant interferon gamma adsorbed on a non-porous reversed-phase silica support. Silicon Dioxide 104-110 interferon gamma Homo sapiens 47-63 7876144-7 1995 Tyrosyl phosphorylated Stat3 is also observed in response to interferon-gamma. cyclo(tyrosyl-tyrosyl) 0-7 interferon gamma Homo sapiens 61-77 7756687-7 1995 A combination of IFN-alpha and IFN-gamma consistently augmented the response of the cell lines to methotrexate, by as much as 75% for one cell line, although the response to the individual IFNs was variable. Methotrexate 98-110 interferon gamma Homo sapiens 31-40 7726518-6 1995 In contrast, ciprofloxacin (282 microM) induced mRNAs for interleukin-2 and IFN-gamma up to 20-fold and 7.8-fold, respectively. Ciprofloxacin 13-26 interferon gamma Homo sapiens 76-85 7726518-8 1995 At high concentrations (> or = 141 microM), ciprofloxacin was a greater inducer of interleukin-2 production and exhibited a higher level of stimulatory action than CP-115,953 on IFN-gamma synthesis. Ciprofloxacin 47-60 interferon gamma Homo sapiens 181-190 7710705-4 1995 Batch feeding of these nutrients did not prevent the decline in 2N glycoform, but the glycosylation pattern of IFN-gamma was affected by the initial glutamine concentration in the culture. Glutamine 149-158 interferon gamma Homo sapiens 111-120 7726518-9 1995 At low concentrations, however, CP-115,953 (< or = 25 microM) was more potent than ciprofloxacin in inducing interleukin-2 and IFN-gamma synthesis. Ciprofloxacin 86-99 interferon gamma Homo sapiens 130-139 7748537-0 1995 Interferon-gamma and interleukin-4 production by human T cells recognizing Leishmania donovani antigens separated by SDS-PAGE. Sodium Dodecyl Sulfate 117-120 interferon gamma Homo sapiens 0-16 7726748-6 1995 Moreover, the effect of dexamethasone on ICAM-1 expression stimulated by IL-1 beta, TNF-alpha and IFN-gamma was observed. Dexamethasone 24-37 interferon gamma Homo sapiens 98-107 7726748-8 1995 Inhibitory effects were exerted by dexamethasone on ICAM-1 expression in cells stimulated by IL-1 beta and IFN-gamma in a dose-dependent manner, but not in cells stimulated by TNF-alpha. Dexamethasone 35-48 interferon gamma Homo sapiens 107-116 7536048-9 1995 Effects of hCG-induced luteinization of cultures on Fas mAb-induced cytotoxicity was examined: combined pretreatment with IFN gamma and hCG induced a synergistic increase in Fas mAb-induced cytotoxicity (40%) over that obtained with IFN gamma-pretreatment alone (15%). ammonium ferrous sulfate 52-55 interferon gamma Homo sapiens 122-131 7873388-8 1995 We next showed that IL-4 and IFN gamma prevent hydrocortisone-induced programmed cell death and that the rescued malignant B cells mainly express CD23 type A. Hydrocortisone 47-61 interferon gamma Homo sapiens 29-38 7720088-4 1995 When IFN-beta-treated cells were incubated in the presence of specified amounts of bacterial lipopolysaccharide (LPS) or liposome-encapsulated muramyl tripeptide (MTP), peak IDO activity increased such that enzyme activity was comparable to maximal activity observed with IFN-gamma-treated cells. mtp 163-166 interferon gamma Homo sapiens 272-281 7720088-1 1995 The tryptophan decyclizing enzyme indoleamine 2,3-dioxygenase (IDO) was induced in human monocyte-derived macrophages (MDM) treated with human recombinant interferon-beta (IFN-beta) or interferon-gamma (IFN-gamma). Tryptophan 4-14 interferon gamma Homo sapiens 185-201 7720088-5 1995 LPS and MTP also upregulated IFN-gamma-mediated IDO activity when suboptimal amounts of IFN-gamma were used. mtp 8-11 interferon gamma Homo sapiens 29-38 7720088-1 1995 The tryptophan decyclizing enzyme indoleamine 2,3-dioxygenase (IDO) was induced in human monocyte-derived macrophages (MDM) treated with human recombinant interferon-beta (IFN-beta) or interferon-gamma (IFN-gamma). Tryptophan 4-14 interferon gamma Homo sapiens 203-212 7720088-5 1995 LPS and MTP also upregulated IFN-gamma-mediated IDO activity when suboptimal amounts of IFN-gamma were used. mtp 8-11 interferon gamma Homo sapiens 88-97 7720088-4 1995 When IFN-beta-treated cells were incubated in the presence of specified amounts of bacterial lipopolysaccharide (LPS) or liposome-encapsulated muramyl tripeptide (MTP), peak IDO activity increased such that enzyme activity was comparable to maximal activity observed with IFN-gamma-treated cells. muramyl tripeptide 143-161 interferon gamma Homo sapiens 272-281 7851006-7 1995 The effect was most pronounced at 1000 ng/ml thalidomide, where inhibition of IFN-gamma and enhancement of IL-4 production was maximal. Thalidomide 45-56 interferon gamma Homo sapiens 78-87 7851006-10 1995 Time course data from thalidomide-treated cultures revealed that the augmented IL-4 production diminished as the culture time increased, whereas IFN-gamma production was significantly increased. Thalidomide 22-33 interferon gamma Homo sapiens 145-154 7875222-3 1995 Initial stimulation of CD4+ cells with anti-CD3 (or the mitogens PHA or PMA+ionomycin) and anti-CD28 monoclonal antibodies induced IL-4, IL-5 and interferon-gamma (IFN-gamma) production and augmented IL-2 production (6- to 11-fold) compared to cells stimulated with anti-CD3 or mitogen alone. Ionomycin 76-85 interferon gamma Homo sapiens 146-162 7875222-3 1995 Initial stimulation of CD4+ cells with anti-CD3 (or the mitogens PHA or PMA+ionomycin) and anti-CD28 monoclonal antibodies induced IL-4, IL-5 and interferon-gamma (IFN-gamma) production and augmented IL-2 production (6- to 11-fold) compared to cells stimulated with anti-CD3 or mitogen alone. Ionomycin 76-85 interferon gamma Homo sapiens 164-173 7853596-14 1995 Expression of RNA with homology to an interferon-gamma-induced human gene was consistently decreased within the hyperplastic region at the downstream polytetrafluoroethylene arterial anastomosis. Polytetrafluoroethylene 150-173 interferon gamma Homo sapiens 38-54 7834638-4 1995 We show that p53-independent induction of WAF1/CIP1 occurs in human leukemia cells treated with 12-O-tetradecanoylphorbol-13-acetate, okadaic acid, or IFN-gamma but not with retinoic acid, vitamin D3, or DMSO. Cholecalciferol 189-199 interferon gamma Homo sapiens 151-160 7834638-4 1995 We show that p53-independent induction of WAF1/CIP1 occurs in human leukemia cells treated with 12-O-tetradecanoylphorbol-13-acetate, okadaic acid, or IFN-gamma but not with retinoic acid, vitamin D3, or DMSO. Dimethyl Sulfoxide 204-208 interferon gamma Homo sapiens 151-160 7761111-6 1995 Significant IL-2, IL-3, IL-4, IL-5 and IFN-gamma mRNA expression was detected in PBMC stimulated with TcA, with expression peaking at 72 h after stimulation. Trichloroacetic Acid 102-105 interferon gamma Homo sapiens 39-48 7553067-8 1995 Pre-exposure in vivo to IFN-beta ser seems to prime the PBMs to respond to in vitro stimulation by IFN-gamma, which otherwise had no effect. Serine 33-36 interferon gamma Homo sapiens 99-108 7530002-6 1995 Inhibition of NOS induction was maximal when curcumin was added together with LPS and IFN-gamma and decreased progressively as the interval between curcumin and LPS/IFN-gamma was increased to 18 h. Curcumin 45-53 interferon gamma Homo sapiens 165-174 7536905-3 1995 Treatment of neuron cultures for 24 h with the combined stimulation of IFN-gamma plus IL-1 beta, TNF-alpha and LPS induced NOS activity by 87-fold which was calcium-independent. Calcium 157-164 interferon gamma Homo sapiens 71-80 7832755-3 1995 The C2 and factor B synthesis induced by IFN-gamma in all three cell types was inhibited by a protein kinase C (PKC) inhibitor, 1-(5-isoquinolinyl-sulphonyl)-2-methylpiperazine (H-7). 1-(5-isoquinolinyl-sulphonyl)-2-methylpiperazine 128-176 interferon gamma Homo sapiens 41-50 7814889-2 1995 Here, we show that in an in vivo model of acute superantigen-driven immune activation, CPZ independently down-regulates the production of various T cell-derived lymphokines (IL-2, IFN-gamma, IL-4, TNF, and GM-CSF) and up-regulates the secretion of IL-10. Chlorpromazine 87-90 interferon gamma Homo sapiens 180-189 7832755-4 1995 The depletion of PKC in these cell types after treatment with phorbol 12-myristate 13-acetate (PMA) resulted in inhibition of IFN-gamma-induced C2 production. Tetradecanoylphorbol Acetate 62-93 interferon gamma Homo sapiens 126-135 7832755-4 1995 The depletion of PKC in these cell types after treatment with phorbol 12-myristate 13-acetate (PMA) resulted in inhibition of IFN-gamma-induced C2 production. Tetradecanoylphorbol Acetate 95-98 interferon gamma Homo sapiens 126-135 7814143-1 1995 We have studied the relationship between L-tryptophan metabolism and the response to human IFN-gamma in 3 human ovarian cancer xenografts growing in nude mice. Tryptophan 41-53 interferon gamma Homo sapiens 91-100 7814399-3 1995 Northern analysis revealed a dose- and time-dependent suppression of BPAG1 expression by IFN-gamma in cultured human keratinocytes from several different donors, and incubation of the cells with IFN-gamma in the presence of cycloheximide demonstrated that this effect required ongoing protein synthesis. Cycloheximide 224-237 interferon gamma Homo sapiens 195-204 7814143-2 1995 During IFN-gamma therapy all 3 tumours showed a profound depletion in L-tryptophan and a corresponding rise in L-kynurenine. Tryptophan 70-82 interferon gamma Homo sapiens 7-16 7814143-2 1995 During IFN-gamma therapy all 3 tumours showed a profound depletion in L-tryptophan and a corresponding rise in L-kynurenine. Kynurenine 111-123 interferon gamma Homo sapiens 7-16 7814143-6 1995 These results show that induction of IDO by IFN-gamma in vivo can metabolize L-tryptophan rapidly enough for it to become depleted, despite a continued supply of L-tryptophan from the host. Tryptophan 77-89 interferon gamma Homo sapiens 44-53 7814143-6 1995 These results show that induction of IDO by IFN-gamma in vivo can metabolize L-tryptophan rapidly enough for it to become depleted, despite a continued supply of L-tryptophan from the host. Tryptophan 162-174 interferon gamma Homo sapiens 44-53 7814143-11 1995 L-tryptophan depletion may be a contributor to a multifactorial growth inhibition of tumour cells following IFN-gamma treatment, but cannot on its own explain their growth inhibition. Tryptophan 0-12 interferon gamma Homo sapiens 108-117 8571734-3 1995 In selected patients anabolic steroids, differentiation inducers such as cis-retinoic acid (RA), interferon alpha or gamma have been claimed to be active. Steroids 30-38 interferon gamma Homo sapiens 97-122 7747530-7 1995 Zn2+ could also reduce the TNF-alpha secretion of keratinocytes stimulated by IFN-gamma or Ni2+ during 48 h. Taken together, these data indicate that zinc can directly reduce some keratinocyte activation markers frequently observed in vivo; this action may be involved in the antiinflammatory effect of Zn(2+)-associated therapies in cutaneous inflammatory reactions. Zinc 0-4 interferon gamma Homo sapiens 78-87 7544060-5 1995 These results also suggest that combined interferon/retinoid therapy may provide an enhanced beneficial effect to reduce cervical tumor size due to the fact that each agent is inhibiting cervical cell proliferation via distinct, but reinforcing, pathways (i.e., IFN gamma reduces E6/E7 expression, RA inhibits the function of the EGF and IGF1 signalling pathways). Retinoids 52-60 interferon gamma Homo sapiens 262-271 8571924-2 1995 Although neither Rg1 nor Rb1 induced nitric oxide from resting macrophages, Rg1 enhanced the production of nitric oxide from IFN-gamma activated-macrophages or RAW cells. Nitric Oxide 107-119 interferon gamma Homo sapiens 125-134 7840140-5 1995 Immunoblotting and immunoprecipitation experiments demonstrated that IFN-gamma induced tyrosine phosphorylation of the p91 component of ISGF3, which is blocked by preincubation of cells with PTK inhibitors. Tyrosine 87-95 interferon gamma Homo sapiens 69-78 7487140-5 1995 The addition of propranolol resulted in prolongation of ICAM-1 expression on keratinocytes induced by IFN gamma. Propranolol 16-27 interferon gamma Homo sapiens 102-111 8744652-4 1995 Recent data indicate that heparin can bind cytokines with potent immune modulatory action (e.g. TNF-alpha, interferon gamma etc.). Heparin 26-33 interferon gamma Homo sapiens 107-123 8571924-5 1995 Rg1 enhanced the tumor cell killing by nitric oxide produced from IFN-gamma-activated macrophages. Nitric Oxide 39-51 interferon gamma Homo sapiens 66-75 8574153-10 1995 PAI was able to induce the production of IFN-gamma and TNF-alpha while that of IL-4 and IL-1 beta was reduced. pai 0-3 interferon gamma Homo sapiens 41-50 7813113-6 1995 Formalin-killed or live L. pneumophila-stimulated PBL expressed the mRNA for IFN-gamma but not the mRNA for IL-4. Formaldehyde 0-8 interferon gamma Homo sapiens 77-86 7813113-10 1995 A significant correlation between the proliferative response to formalin-killed L. pneumophila and IFN-gamma release in culture was observed (r = 0.6932, P < 0.001) in PBL from 30 healthy volunteers. Formaldehyde 64-72 interferon gamma Homo sapiens 99-108 7749068-4 1995 In all these cell lines the level of gamma 2 mRNA increased 2-4 h after induction reaching a stable plateau after 8-12 h. The IFN-gamma induction of gamma 2 mRNA could be blocked by cycloheximide in human amniotic (AMA) cells, epithelial HeLa cells and HT1080 fibroblasts, but not in T98G glioblastoma cells. Cycloheximide 182-195 interferon gamma Homo sapiens 126-135 7843254-1 1995 Prostaglandin E2 (PGE2) favors T helper type 2 (Th2)-like cytokine secretion profiles in murine and human CD4+ T cells by inhibiting the production of the Th1-associated cytokines interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) and up-regulating the production of the Th2-associated cytokines IL-4 and IL-5 in a dose-dependent way. Dinoprostone 0-16 interferon gamma Homo sapiens 205-221 7843254-1 1995 Prostaglandin E2 (PGE2) favors T helper type 2 (Th2)-like cytokine secretion profiles in murine and human CD4+ T cells by inhibiting the production of the Th1-associated cytokines interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) and up-regulating the production of the Th2-associated cytokines IL-4 and IL-5 in a dose-dependent way. Dinoprostone 0-16 interferon gamma Homo sapiens 223-232 7843254-1 1995 Prostaglandin E2 (PGE2) favors T helper type 2 (Th2)-like cytokine secretion profiles in murine and human CD4+ T cells by inhibiting the production of the Th1-associated cytokines interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) and up-regulating the production of the Th2-associated cytokines IL-4 and IL-5 in a dose-dependent way. Dinoprostone 18-22 interferon gamma Homo sapiens 205-221 7529187-3 1995 We report that both IFN-alpha and IFN-gamma induce a 3- to 5-fold increased expression of p91, p84, and p113 and their phosphotyrosine contents in a dose- and time-dependent manner. Phosphotyrosine 119-134 interferon gamma Homo sapiens 34-43 7843254-1 1995 Prostaglandin E2 (PGE2) favors T helper type 2 (Th2)-like cytokine secretion profiles in murine and human CD4+ T cells by inhibiting the production of the Th1-associated cytokines interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) and up-regulating the production of the Th2-associated cytokines IL-4 and IL-5 in a dose-dependent way. Dinoprostone 18-22 interferon gamma Homo sapiens 223-232 7995773-3 1995 RESULTS: Interferon-gamma was detectable in bronchoalveolar lavage fluid (BALF) samples taken 3 h after inhalation in doses of > or = 0.6 mg. Before inhalation, AM in four out of seven patients studied showed vigorous lucigenin-enhanced CL responses to N-formyl-methionyl-leucyl-phenylalanine and opsonized zymosan particles. 10,10'-dimethyl-9,9'-biacridinium 221-230 interferon gamma Homo sapiens 9-25 7812167-10 1995 The spontaneous production of IFN-gamma in the cultures did not differ between the groups, but upon stimulation with phorbol myristate acetate, the atopic dermatitis group demonstrated significantly lower IFN-gamma levels compared to the two other groups. Tetradecanoylphorbol Acetate 117-142 interferon gamma Homo sapiens 205-214 7995773-3 1995 RESULTS: Interferon-gamma was detectable in bronchoalveolar lavage fluid (BALF) samples taken 3 h after inhalation in doses of > or = 0.6 mg. Before inhalation, AM in four out of seven patients studied showed vigorous lucigenin-enhanced CL responses to N-formyl-methionyl-leucyl-phenylalanine and opsonized zymosan particles. Zymosan 310-317 interferon gamma Homo sapiens 9-25 8699867-3 1995 The results showed that PTX at 5 x 10(-4) M concentration selectively suppressed Th-1 cytokines [interleukin-2 (IL-2) and interferon-gamma (IFN-gamma)] but not IL-4, as observed by the measurement of protein secretion. Pentoxifylline 24-27 interferon gamma Homo sapiens 122-138 8699867-3 1995 The results showed that PTX at 5 x 10(-4) M concentration selectively suppressed Th-1 cytokines [interleukin-2 (IL-2) and interferon-gamma (IFN-gamma)] but not IL-4, as observed by the measurement of protein secretion. Pentoxifylline 24-27 interferon gamma Homo sapiens 140-149 8699867-4 1995 Using sensitive RT-PCR assays, data show that at this same PTX concentration (5 x 10(-4) M), these cells also exhibited inhibition in the expression of IL-4 and IL-10 mRNA, together with inhibition of IL-2 and IFN-gamma mRNA expression. Pentoxifylline 59-62 interferon gamma Homo sapiens 210-219 8699867-7 1995 Our findings showed that PTX at the appropriate concentrations could induce selective suppression of IL-2 and IFN-gamma, whereas at high concentrations this drug could act as a suppressive agent of both Th1- and Th2-derived cytokines. Pentoxifylline 25-28 interferon gamma Homo sapiens 110-119 7528246-5 1995 In addition, at low (5 U/ml) concentrations of IFN-gamma, cell proliferation and protein synthesis decreased, as determined by 3H-thymidine labeling and 14C-amino acid uptake. Tritium 127-129 interferon gamma Homo sapiens 47-56 7807013-0 1995 Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma. Steroids 87-94 interferon gamma Homo sapiens 51-67 7807013-3 1995 By contrast, steroid-sensitive (SS) asthmatics respond well to glucocorticoids, and this is accompanied by a decrease in the numbers of bronchoalveolar lavage (BAL) messenger RNA+ (mRNA+) cells expressing IL-4 and IL-5, and an increase in interferon gamma (IFN-gamma) transcripts. Steroids 13-20 interferon gamma Homo sapiens 239-266 7995951-0 1995 IgG immune complexes inhibit IFN-gamma-induced transcription of the Fc gamma RI gene in human monocytes by preventing the tyrosine phosphorylation of the p91 (Stat1) transcription factor. Tyrosine 122-130 interferon gamma Homo sapiens 29-38 7995951-2 1995 Because many genes, including MHC class II Ags, transcriptionally activated by IFN-gamma require the tyrosine phosphorylation of the transcription factor p91 (Stat1), we examined whether IC could suppress IFN-gamma-induced expression of the Fc gamma receptor I gene (Fc gamma RI) in human monocytes and whether this occurred through inhibition of p91 phosphorylation. Tyrosine 101-109 interferon gamma Homo sapiens 79-88 7995951-8 1995 Pretreatment with IC resulted in the inhibition of the tyrosine phosphorylation of the tyrosine kinases, Jak1 and Jak2, both of which are involved in IFN-gamma signal transduction. Tyrosine 55-63 interferon gamma Homo sapiens 150-159 7995951-9 1995 Therefore, culture of monocytes on IC inhibits IFN-gamma-induced expression of the Fc gamma RI gene by preventing tyrosine phosphorylation of p91, probably by the associated inhibition of the tyrosine kinases Jak1 and Jak2. Tyrosine 114-122 interferon gamma Homo sapiens 47-56 7528246-5 1995 In addition, at low (5 U/ml) concentrations of IFN-gamma, cell proliferation and protein synthesis decreased, as determined by 3H-thymidine labeling and 14C-amino acid uptake. Thymidine 130-139 interferon gamma Homo sapiens 47-56 7528246-5 1995 In addition, at low (5 U/ml) concentrations of IFN-gamma, cell proliferation and protein synthesis decreased, as determined by 3H-thymidine labeling and 14C-amino acid uptake. Carbon-14 153-156 interferon gamma Homo sapiens 47-56 18475641-6 1995 When the in vitro results are transferred to live animals using the same inducing agents and pathway inhibitors, it is found that theophylline (Ca(2+)/CaM inhibitor) and anti-p21(ras) are the most potent suppressors of the IFN-gamma- and 5-azaC-induced side effects during pregnancy. Theophylline 130-142 interferon gamma Homo sapiens 223-232 7623327-2 1995 Gonadotrophin-stimulated progesterone production is inhibited by interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), or gamma-interferon (IFN-gamma), the last two cytokine being more effective than IL-1. Progesterone 25-37 interferon gamma Homo sapiens 160-169 18475655-1 1995 Human monocytes, preincubated with IFN-gamma respond to IL-4 by a cGMP increase through activation of an inducible NO synthase. Cyclic GMP 66-70 interferon gamma Homo sapiens 35-44 7724484-8 1995 We have studied the interactions of various non-ionic surfactants like Brij and Tween with recombinant human growth hormone and recombinant human interferon-gamma and obtained corresponding binding stoichiometries. Polysorbates 80-85 interferon gamma Homo sapiens 146-162 7603365-2 1995 Neopterin secretion by U937 cells was enhanced by the addition of human interferon gamma (IFN-gamma). Neopterin 0-9 interferon gamma Homo sapiens 72-99 7527439-5 1994 Supernatants of phorbol-12,13-dibutyrate (PDBu) stimulated human epidermoid carcinoma cell lines (KB, A431) induced IFN-gamma production by PBL. Phorbol 12,13-Dibutyrate 16-40 interferon gamma Homo sapiens 116-125 8524964-3 1995 These effects were related to the ability of MLA to suppress accumulation of TNF-alpha and IFN-gamma in the bloodstream of animals. monophosphoryl lipid A 45-48 interferon gamma Homo sapiens 91-100 7527439-5 1994 Supernatants of phorbol-12,13-dibutyrate (PDBu) stimulated human epidermoid carcinoma cell lines (KB, A431) induced IFN-gamma production by PBL. Phorbol 12,13-Dibutyrate 42-46 interferon gamma Homo sapiens 116-125 7847672-10 1994 In addition, gamma interferon (IFN-gamma) stimulation of macrophages induce release of the glutamate-like agonist quinolinate. Glutamic Acid 91-100 interferon gamma Homo sapiens 13-40 7847672-10 1994 In addition, gamma interferon (IFN-gamma) stimulation of macrophages induce release of the glutamate-like agonist quinolinate. Quinolinic Acid 114-125 interferon gamma Homo sapiens 13-40 7989763-6 1994 Exposure of cord and adult macrophages to IFN-gamma (10-500 U/ml) gave quantitatively different results in Candida killing, as well as in release of superoxide anion (O2-). Superoxides 149-165 interferon gamma Homo sapiens 42-51 7989763-6 1994 Exposure of cord and adult macrophages to IFN-gamma (10-500 U/ml) gave quantitatively different results in Candida killing, as well as in release of superoxide anion (O2-). Superoxides 167-169 interferon gamma Homo sapiens 42-51 7994750-3 1994 Moreover, concurrent treatment of partially purified T cells (> 90% CD3+) with PHA and rIL-12 selectively enhanced IFN-gamma mRNA stability and protein production, while IL-2 protein and mRNA levels were unaffected. ril-12 90-96 interferon gamma Homo sapiens 118-127 7809939-1 1994 Heparin antagonizes the induction of class II MHC molecules by interferon-gamma. Heparin 0-7 interferon gamma Homo sapiens 63-79 7881153-11 1994 It has recently become evident that nitric oxide, produced by macrophages and other cell types in response to interferon-gamma, induces the IRE-binding activity of IRF. Nitric Oxide 36-48 interferon gamma Homo sapiens 110-126 8002245-9 1994 These inhibitory effects of TGF-beta were augmented by pretreatment with either PMA or calphostin C. Pretreatment of the cells with PMA before stimulation with IFN-gamma downregulated HLA-DR expression. Tetradecanoylphorbol Acetate 80-83 interferon gamma Homo sapiens 160-169 7528668-4 1994 In contrast, stat1 proteins were not tyrosine phosphorylated after IL-2 ligation, whereas tyrosine-phosphorylated stat1 proteins (91 and 84 kDa proteins) were translocated to the nucleus following interferon-gamma treatment of HeLa cells. Tyrosine 90-98 interferon gamma Homo sapiens 197-213 7890801-7 1994 Cytokines such as IFN alpha, IFN gamma, G-CSF, TNF alpha, IL-1, and IL-4 markedly potentiate the differentiation-inducing effect of retinoids. Retinoids 132-141 interferon gamma Homo sapiens 29-38 7798616-4 1994 N-acetyl-L-cysteine also suppressed keratinocyte surface expression of ICAM-1 induced by the cytokines interferon-gamma (IFN-gamma) or tumor necrosis factor-alpha (TNF-alpha), whereas pyrrolidine dithiocarbamate and alpha-tocopherol suppressed IFN-gamma-induced surface expression but not TNF-alpha-induced expression. Acetylcysteine 0-19 interferon gamma Homo sapiens 103-119 7798616-4 1994 N-acetyl-L-cysteine also suppressed keratinocyte surface expression of ICAM-1 induced by the cytokines interferon-gamma (IFN-gamma) or tumor necrosis factor-alpha (TNF-alpha), whereas pyrrolidine dithiocarbamate and alpha-tocopherol suppressed IFN-gamma-induced surface expression but not TNF-alpha-induced expression. Acetylcysteine 0-19 interferon gamma Homo sapiens 121-130 7798616-4 1994 N-acetyl-L-cysteine also suppressed keratinocyte surface expression of ICAM-1 induced by the cytokines interferon-gamma (IFN-gamma) or tumor necrosis factor-alpha (TNF-alpha), whereas pyrrolidine dithiocarbamate and alpha-tocopherol suppressed IFN-gamma-induced surface expression but not TNF-alpha-induced expression. Acetylcysteine 0-19 interferon gamma Homo sapiens 244-253 7798616-5 1994 We found that N-acetyl-L-cysteine treatment reduced ICAM-1 mRNA levels when keratinocytes were stimulated with either IFN-gamma or TNF-alpha; however, pyrrolidine dithiocarbamate and alpha-tocopherol had no effect on either IFN-gamma- or TNF-alpha-induced ICAM-1 mRNA levels. Acetylcysteine 14-33 interferon gamma Homo sapiens 118-127 7798616-5 1994 We found that N-acetyl-L-cysteine treatment reduced ICAM-1 mRNA levels when keratinocytes were stimulated with either IFN-gamma or TNF-alpha; however, pyrrolidine dithiocarbamate and alpha-tocopherol had no effect on either IFN-gamma- or TNF-alpha-induced ICAM-1 mRNA levels. Acetylcysteine 14-33 interferon gamma Homo sapiens 224-233 7897256-1 1994 Induction of gene expression by interferon-gamma involves the activation of a latent cytoplasmic transcription factor, p91, by phosphorylation on a single tyrosyl residue. cyclo(tyrosyl-tyrosyl) 155-162 interferon gamma Homo sapiens 32-48 8002245-10 1994 Staurosporine pretreatment suppressed HLA-DR expression by IFN-gamma-stimulated RPE cells, but this was not additive with TGF-beta. Staurosporine 0-13 interferon gamma Homo sapiens 59-68 8002245-12 1994 The modulation of these IFN-gamma and TGF-beta effects by calphostin C, staurosporine, and PMA treatment suggests involvement of the protein kinase C pathway. calphostin C 58-70 interferon gamma Homo sapiens 24-33 8002245-12 1994 The modulation of these IFN-gamma and TGF-beta effects by calphostin C, staurosporine, and PMA treatment suggests involvement of the protein kinase C pathway. Staurosporine 72-85 interferon gamma Homo sapiens 24-33 8002245-12 1994 The modulation of these IFN-gamma and TGF-beta effects by calphostin C, staurosporine, and PMA treatment suggests involvement of the protein kinase C pathway. Tetradecanoylphorbol Acetate 91-94 interferon gamma Homo sapiens 24-33 7996055-8 1994 Enhanced SAA3 expression by DEX was inhibited by treatment with IFN-gamma in a dose-dependent manner. Dexamethasone 28-31 interferon gamma Homo sapiens 64-73 7996055-10 1994 The timing of the effects of IFN-gamma and TGF-beta 1 on DEX-induced SAA3 expression differed: IFN-gamma showed its effect between 30 h before and 18 h after DEX administration, whereas TGF-beta 1 showed an effect when administered concomitantly with DEX and in the late stages after DEX administration. Dexamethasone 57-60 interferon gamma Homo sapiens 29-38 7996055-10 1994 The timing of the effects of IFN-gamma and TGF-beta 1 on DEX-induced SAA3 expression differed: IFN-gamma showed its effect between 30 h before and 18 h after DEX administration, whereas TGF-beta 1 showed an effect when administered concomitantly with DEX and in the late stages after DEX administration. Dexamethasone 57-60 interferon gamma Homo sapiens 95-104 7996055-10 1994 The timing of the effects of IFN-gamma and TGF-beta 1 on DEX-induced SAA3 expression differed: IFN-gamma showed its effect between 30 h before and 18 h after DEX administration, whereas TGF-beta 1 showed an effect when administered concomitantly with DEX and in the late stages after DEX administration. Dexamethasone 158-161 interferon gamma Homo sapiens 95-104 7996055-10 1994 The timing of the effects of IFN-gamma and TGF-beta 1 on DEX-induced SAA3 expression differed: IFN-gamma showed its effect between 30 h before and 18 h after DEX administration, whereas TGF-beta 1 showed an effect when administered concomitantly with DEX and in the late stages after DEX administration. Dexamethasone 158-161 interferon gamma Homo sapiens 95-104 7996055-10 1994 The timing of the effects of IFN-gamma and TGF-beta 1 on DEX-induced SAA3 expression differed: IFN-gamma showed its effect between 30 h before and 18 h after DEX administration, whereas TGF-beta 1 showed an effect when administered concomitantly with DEX and in the late stages after DEX administration. Dexamethasone 158-161 interferon gamma Homo sapiens 95-104 8521029-8 1994 RESULTS: Carbon tetrachloride caused histological fibrosis, which was significantly reduced on a quantitative basis by interferon gamma. Carbon Tetrachloride 9-29 interferon gamma Homo sapiens 119-135 7704538-3 1994 When T2 (5"GGGGTTGGTTGTGTTGGGTGTTGTGTRNH(2)3") oligonucleotide was added at 5-20 microM every other day, cell surface induction of HLA-DR and HLA-DP by IFN-gamma was suppressed in a dose-dependent manner in HeLa S3. t2 (5"ggggttggttgtgttgggtgttgtgtrnh(2)3") oligonucleotide 5-62 interferon gamma Homo sapiens 152-161 7963563-5 1994 Both tepoxalin and CsA did not inhibit the expression of IL-2R; however, only tepoxalin, but not CsA, inhibited the proliferation of IL-2-dependent blasts and the transcription of IFN-gamma, an IL-2-dependent target gene. tepoxalin 78-87 interferon gamma Homo sapiens 180-189 7704538-0 1994 Suppression of interferon-gamma induction of MHC class II and ICAM-1 by a 26-base oligonucleotide composed of deoxyguanosine and deoxythymidine. -base oligonucleotide 76-97 interferon gamma Homo sapiens 15-31 7704538-7 1994 The suppressive effect of T2 was also reversible as continued culture of the treated cells without further addition of the oligonucleotide allowed full re-expression of HLA-DR. Further experiments showed that T2 oligonucleotide was also able to inhibit IFN-gamma enhancement of ICAM-1 (CD54) on human corneal endothelial cell and human retinal pigmented epithelial cell. t2 oligonucleotide 209-227 interferon gamma Homo sapiens 253-262 7704538-0 1994 Suppression of interferon-gamma induction of MHC class II and ICAM-1 by a 26-base oligonucleotide composed of deoxyguanosine and deoxythymidine. Deoxyguanosine 110-124 interferon gamma Homo sapiens 15-31 7704538-0 1994 Suppression of interferon-gamma induction of MHC class II and ICAM-1 by a 26-base oligonucleotide composed of deoxyguanosine and deoxythymidine. Thymidine 129-143 interferon gamma Homo sapiens 15-31 7704538-8 1994 We conclude that T2 oligonucleotide is effective at suppressing HLA-DR, HLA-DP and ICAM-1 induction by IFN-gamma in transformed and nontransformed cells in vitro. t2 oligonucleotide 17-35 interferon gamma Homo sapiens 103-112 7974717-2 1994 Increased IL-2 and IFN-gamma mRNA expression were observed in 15-deoxyspergualin-treated bone marrow cells. gusperimus 62-80 interferon gamma Homo sapiens 19-28 7974717-1 1994 Reverse transcriptase-polymerase chain reaction showed that interleukin 3, IL-4, IL-5, IL-6, interferon-gamma and stem cell factor mRNA expression were higher in 15-deoxyspergualin-treated spleen cells than in control spleen cells. gusperimus 165-180 interferon gamma Homo sapiens 93-109 7526699-6 1994 Assays of adenosine 3",5"-cyclic monophosphate-stimulated 36Cl- efflux and whole cell currents show that CFTR function is diminished in IFN-gamma-treated cells. Cyclic AMP 10-46 interferon gamma Homo sapiens 136-145 7526699-6 1994 Assays of adenosine 3",5"-cyclic monophosphate-stimulated 36Cl- efflux and whole cell currents show that CFTR function is diminished in IFN-gamma-treated cells. Chlorine-36 58-62 interferon gamma Homo sapiens 136-145 7948314-0 1994 Is alpha-methyldopa-type autoimmune hemolytic anemia mediated by interferon-gamma? Methyldopa 3-19 interferon gamma Homo sapiens 65-81 7948314-7 1994 After stimulation with phytohemagglutinin (PHA), mitogen-induced concentrations of interferon-gamma were significantly higher in the patients treated with lisuride than in the control group. Lisuride 155-163 interferon gamma Homo sapiens 83-99 7948314-10 1994 It might be supposed that alpha-methyldopa-type autoimmune hemolytic anemia is mediated by elevated levels of interferon-gamma produced in T cells after a stimulatory signal. Methyldopa 26-42 interferon gamma Homo sapiens 110-126 7872669-3 1994 IFN-gamma, all-trans retinoic acid and phorbol ester (TPA) induced up-regulation of CD66 antigen(s) recognized by the monoclonal antibody F34-187 (as determined by flow cytometry). Tetradecanoylphorbol Acetate 54-57 interferon gamma Homo sapiens 0-9 7980452-0 1994 Role of N-glycosylation in the synthesis, dimerization and secretion of human interferon-gamma. Nitrogen 8-9 interferon gamma Homo sapiens 78-94 7525556-0 1994 Differential tyrosine phosphorylation of JAK1, JAK2, and STAT1 by growth hormone and interferon-gamma in IM-9 cells. Tyrosine 13-21 interferon gamma Homo sapiens 85-101 7525556-1 1994 Both the growth hormone (GH) and interferon gamma (IFN gamma) receptors are members of the cytokine receptor family that activate tyrosine phosphorylation despite the lack of a tyrosine kinase domain. Tyrosine 130-138 interferon gamma Homo sapiens 33-49 7525556-1 1994 Both the growth hormone (GH) and interferon gamma (IFN gamma) receptors are members of the cytokine receptor family that activate tyrosine phosphorylation despite the lack of a tyrosine kinase domain. Tyrosine 130-138 interferon gamma Homo sapiens 51-60 7525556-3 1994 We demonstrate that, in the human IM-9 lymphocyte, both JAK1 and JAK2 are tyrosine-phosphorylated in response to IFN gamma, whereas only JAK2 is tyrosine-phosphorylated in response to GH. Tyrosine 74-82 interferon gamma Homo sapiens 113-122 7525556-6 1994 Furthermore, we demonstrate that although IFN gamma activates the tyrosine phosphorylation of the p91 signal transducer and activator of transcription (STAT1) in IM-9 cells, GH does not. Tyrosine 66-74 interferon gamma Homo sapiens 42-51 7980452-1 1994 Human interferon-gamma (IFN-gamma) is a secretory glycoprotein, which has two potential N-linked glycosylation sites at positions Asn-25 and Asn-97 of its 143 amino acid long mature polypeptide chain. Nitrogen 26-27 interferon gamma Homo sapiens 6-22 7980452-1 1994 Human interferon-gamma (IFN-gamma) is a secretory glycoprotein, which has two potential N-linked glycosylation sites at positions Asn-25 and Asn-97 of its 143 amino acid long mature polypeptide chain. Asparagine 130-133 interferon gamma Homo sapiens 6-22 7980452-1 1994 Human interferon-gamma (IFN-gamma) is a secretory glycoprotein, which has two potential N-linked glycosylation sites at positions Asn-25 and Asn-97 of its 143 amino acid long mature polypeptide chain. Asparagine 130-133 interferon gamma Homo sapiens 24-33 7980452-1 1994 Human interferon-gamma (IFN-gamma) is a secretory glycoprotein, which has two potential N-linked glycosylation sites at positions Asn-25 and Asn-97 of its 143 amino acid long mature polypeptide chain. Asparagine 141-144 interferon gamma Homo sapiens 6-22 7980452-1 1994 Human interferon-gamma (IFN-gamma) is a secretory glycoprotein, which has two potential N-linked glycosylation sites at positions Asn-25 and Asn-97 of its 143 amino acid long mature polypeptide chain. Asparagine 141-144 interferon gamma Homo sapiens 24-33 7980452-2 1994 In order to understand the role of glycan residues in the synthesis and secretion of human IFN-gamma, both or either one of the potential N-linked glycosylation sites were mutated to Gln. Polysaccharides 35-41 interferon gamma Homo sapiens 91-100 7980452-2 1994 In order to understand the role of glycan residues in the synthesis and secretion of human IFN-gamma, both or either one of the potential N-linked glycosylation sites were mutated to Gln. Glutamine 183-186 interferon gamma Homo sapiens 91-100 7980452-7 1994 The formation of biologically active dimers was more efficient for IFN-gamma polypeptides that had the intact glycosylation site at Asn-25 as compared with the other two mutant forms of IFN-gamma. Asparagine 132-135 interferon gamma Homo sapiens 67-76 7882138-4 1994 An enhanced response was observed when monocytes were preincubated with IFN-gamma and whether the cGMP accumulation was still abrogated in the presence of LNMMA it was not affected by either EGTA or W7 suggesting, in that case, the activation of an inducible NOS (iNOS). Cyclic GMP 98-102 interferon gamma Homo sapiens 72-81 7927758-5 1994 Maximum inhibition was obtained at 1,000 U of IFN-gamma per ml with phorbol myristic acetate-treated THP-1 cells. Acetates 85-92 interferon gamma Homo sapiens 46-55 7867888-2 1994 We analysed a dinucleotide repeat polymorphism within the first intron of the interferon gamma (IFN-gamma) gene in Japanese diabetic patients (175 IDDM and 145 non-insulin-dependent diabetes mellitus) and 267 control subjects. Dinucleoside Phosphates 14-26 interferon gamma Homo sapiens 78-105 7927758-12 1994 These results indicate that (i) E. chaffeensis is sensitive to intracytoplasmic iron depletion, (ii) E. chaffeensis is sensitive to IFN-gamma-induced killing, and (iii) the anti-ehrlichial activity induced in human monocytes by IFN-gamma is mediated by limitation of available cytoplasmic iron and is not due to the generation of reactive oxygen intermediates or nitric oxide. reactive oxygen 330-345 interferon gamma Homo sapiens 132-141 7927758-12 1994 These results indicate that (i) E. chaffeensis is sensitive to intracytoplasmic iron depletion, (ii) E. chaffeensis is sensitive to IFN-gamma-induced killing, and (iii) the anti-ehrlichial activity induced in human monocytes by IFN-gamma is mediated by limitation of available cytoplasmic iron and is not due to the generation of reactive oxygen intermediates or nitric oxide. Nitric Oxide 363-375 interferon gamma Homo sapiens 132-141 7927758-12 1994 These results indicate that (i) E. chaffeensis is sensitive to intracytoplasmic iron depletion, (ii) E. chaffeensis is sensitive to IFN-gamma-induced killing, and (iii) the anti-ehrlichial activity induced in human monocytes by IFN-gamma is mediated by limitation of available cytoplasmic iron and is not due to the generation of reactive oxygen intermediates or nitric oxide. Iron 289-293 interferon gamma Homo sapiens 132-141 7829998-3 1994 In the present study, TNF-alpha, TNF-beta and IFN-gamma all inhibited thyroglobulin (Tg) and cAMP production from cultured human thyroid cells. Cyclic AMP 93-97 interferon gamma Homo sapiens 46-55 7829998-6 1994 IFN-gamma (10(4) U/l) added together with IL-1 beta in lower concentrations (1-10(2) U/l) stimulated cAMP production, while at high concentrations of IL-1 beta (10(5) U/l), IFN-gamma enhanced the inhibitory influence of IL-1 beta on Tg production. Cyclic AMP 101-105 interferon gamma Homo sapiens 0-9 7883861-6 1994 Acute in vitro ethanol treatment down-regulated the elevated TNF alpha production by trauma patients" M0 after either SEB, muramyl-dipeptide (MDP), interferon-gamma plus MDP, or lipopolysaccharide (LPS) stimulation. Ethanol 15-22 interferon gamma Homo sapiens 148-164 7964451-0 1994 Toxoplasma gondii alters eicosanoid release by human mononuclear phagocytes: role of leukotrienes in interferon gamma-induced antitoxoplasma activity. Leukotrienes 85-97 interferon gamma Homo sapiens 101-117 7964451-9 1994 IFN-gamma-induced antitoxoplasma activity in monocyte-derived macrophages was inhibited by the selective 5-lipoxygenase inhibitor zileuton but not by the cyclooxygenase inhibitor indomethacin. zileuton 130-138 interferon gamma Homo sapiens 0-9 7964172-1 1994 Neopterin is a pteridine produced by human mononuclear phagocytes, usually in response to interferon-gamma (IFN-gamma) stimulation. Neopterin 0-9 interferon gamma Homo sapiens 90-106 7964451-10 1994 These findings suggest a novel role for 5-lipoxygenase arachidonic acid products in human macrophage IFN-gamma-induced antitoxoplasma activity. Arachidonic Acid 55-71 interferon gamma Homo sapiens 101-110 7964172-1 1994 Neopterin is a pteridine produced by human mononuclear phagocytes, usually in response to interferon-gamma (IFN-gamma) stimulation. Neopterin 0-9 interferon gamma Homo sapiens 108-117 7964172-1 1994 Neopterin is a pteridine produced by human mononuclear phagocytes, usually in response to interferon-gamma (IFN-gamma) stimulation. Pteridines 15-24 interferon gamma Homo sapiens 90-106 7722866-0 1994 Inhibitory effect of melatonin on production of IFN gamma or TNF alpha in peripheral blood mononuclear cells of some blood donors. Melatonin 21-30 interferon gamma Homo sapiens 48-57 7722866-2 1994 The purpose of this study was to examine the effect of melatonin on the production of interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) by peripheral blood mononuclear cells (PBMC) in culture. Melatonin 55-64 interferon gamma Homo sapiens 86-102 7964172-1 1994 Neopterin is a pteridine produced by human mononuclear phagocytes, usually in response to interferon-gamma (IFN-gamma) stimulation. Pteridines 15-24 interferon gamma Homo sapiens 108-117 7722866-2 1994 The purpose of this study was to examine the effect of melatonin on the production of interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) by peripheral blood mononuclear cells (PBMC) in culture. Melatonin 55-64 interferon gamma Homo sapiens 104-113 7964172-5 1994 The HIV-infected cells responded to stimulation with IFN-gamma as well as uninfected cells, with a 6- to 12-fold increase in neopterin production. Neopterin 125-134 interferon gamma Homo sapiens 53-62 7964172-6 1994 We conclude that elevated serum levels of neopterin in HIV-infected individuals are not caused by HIV-1 infection of mononuclear phagocytes but may be a result of the normal response to mononuclear phagocytes to increased levels of IFN-gamma. Neopterin 42-51 interferon gamma Homo sapiens 232-241 7837726-11 1994 Further, in an in vitro study with human lung macrophages, IFN-gamma enhanced the killing activity of macrophages against M. tuberculosis in a dose dependent manner, and suboptimal dose of 1 alpha, 25-dihydroxyvitamin D3 synergistically augmented the effect of IFN-gamma. alpha, 25-dihydroxyvitamin d3 191-220 interferon gamma Homo sapiens 261-270 7853122-9 1994 These results indicate that IL-8 production by HGF is synergistically stimulated by specific cytokines, IL-1 beta and TNF-alpha, and suggest that these stimulatory effects are down-regulated by IFN-gamma at the transcriptional level through PGE2-independent pathways. Dinoprostone 241-245 interferon gamma Homo sapiens 194-203 7929128-0 1994 Characterization of the oligodeoxynucleotide-mediated inhibition of interferon-gamma-induced major histocompatibility complex class I and intercellular adhesion molecule-1. Oligodeoxyribonucleotides 24-44 interferon gamma Homo sapiens 68-84 7930584-6 1994 Furthermore, rIL-12 stimulated proliferation of CD4+ type 1 T cell clones from tuberculoid lesions, but not CD8+ type 2 T cell clones from lepromatous lesions; however, both responded to rIL-2, rIL-12 augmented M. leprae-specific T cell proliferation in lepromatous patients, thereby causing the selective expansion of CD4+ T cells and increasing T cell IFN-gamma production. ril-12 13-19 interferon gamma Homo sapiens 354-363 7929128-11 1994 Thus, oligo I appears to specifically inhibit interferon-gamma-induced changes in protein expression, which is consistent with oligo I acting at an early step(s) in the induction process. oligo i 6-13 interferon gamma Homo sapiens 46-62 7929128-11 1994 Thus, oligo I appears to specifically inhibit interferon-gamma-induced changes in protein expression, which is consistent with oligo I acting at an early step(s) in the induction process. oligo i 127-134 interferon gamma Homo sapiens 46-62 7999637-4 1994 Interferon-gamma also induced a 35% increase in binding of FITC-LPS in U937 cells (P < 0.0001 vs control cells). fitc-lps 59-67 interferon gamma Homo sapiens 0-16 7835947-4 1994 We demonstrate that the capacity of dexamethasone to up-regulate GM-CSF-induced MHC class II expression correlates with the capacity to up-regulate GM-CSF receptor, but not the interferon-gamma (IFN-gamma) receptor, in a highly dose-dependent manner on monocytes. Dexamethasone 36-49 interferon gamma Homo sapiens 177-193 7861198-4 1994 A synergistic effect was observed in the LoVo/Dx cell line when doxorubicin was added after exposure to 0.1-10 U/ml of IFN-gamma. Doxorubicin 64-75 interferon gamma Homo sapiens 119-128 7861198-5 1994 Our data indicate that the effects of IFN-gamma, independent from action on cell proliferation and from modulation of p-glycoprotein expression, are a cause of the synergistic activity between this lymphokine and conventional chemotherapeutic agents such as doxorubicin. Doxorubicin 258-269 interferon gamma Homo sapiens 38-47 7929601-6 1994 Palmitic acid enhanced the release of IFN-gamma at concentrations that diminished TNF-alpha production. Palmitic Acid 0-13 interferon gamma Homo sapiens 38-47 7861027-2 1994 Both IFN-gamma and IFN-alpha mRNA, as estimated by dot blot analysis, were increased in Crohn"s disease (LPMC), although the relative amounts of IFN mRNA appeared to differ among patients. lpmc 105-109 interferon gamma Homo sapiens 5-14 7861027-4 1994 Only minute amounts of IFN-gamma RNA were found sporadically in control LPMC while no IFN-alpha was detected. lpmc 72-76 interferon gamma Homo sapiens 23-32 7930684-2 1994 To determine if antisense oligonucleotides designed to hybridize to various ICAM-1 mRNA regions could selectively influence cultured keratinocyte ICAM-1 expression following gamma interferon (IFN-gamma), cells were exposed to several antisense compounds, in the absence and presence of cationic lipid (lipofectin). Oligonucleotides 26-42 interferon gamma Homo sapiens 174-201 7930684-5 1994 Using flow cytometry, IFN-gamma-inducible ICAM-1 expression was reduced 50% by antisense compounds with lipofectin, and by 30% without lipofectin. 1,2-dielaidoylphosphatidylethanolamine 104-114 interferon gamma Homo sapiens 22-31 7930684-5 1994 Using flow cytometry, IFN-gamma-inducible ICAM-1 expression was reduced 50% by antisense compounds with lipofectin, and by 30% without lipofectin. 1,2-dielaidoylphosphatidylethanolamine 135-145 interferon gamma Homo sapiens 22-31 8089503-2 1994 Patients with myasthenia gravis have peripheral blood T cells that are stimulated to secrete IFN-gamma and IL-2 by human monoclonal anti-acetylcholine receptor and anti-idiotypic Abs. Acetylcholine 137-150 interferon gamma Homo sapiens 93-102 7899141-0 1994 Interferon-gamma, an anti-fibrogenic cytokine which binds to heparan sulfate. Heparitin Sulfate 61-76 interferon gamma Homo sapiens 0-16 7899141-4 1994 In vivo, it is postulated that the heparan sulfate/IFN-gamma interaction can modulate the activity and availability of the cytokine. Heparitin Sulfate 35-50 interferon gamma Homo sapiens 51-60 7863302-0 1994 CD8 T-cell clones producing interleukin-5 and interferon-gamma in bronchial mucosa of patients with asthma induced by toluene diisocyanate. Toluene 2,4-Diisocyanate 118-138 interferon gamma Homo sapiens 46-62 7799571-9 1994 Further, in an in vitro study with human lung macrophages, IFN-gamma enhanced the killing activity of macrophages against M. tuberculosis in a dose dependent manner, and suboptimal dose of 1 alpha, 25-dihydroxyvitamin D3 synergistically augmented the effect of IFN-gamma. alpha, 25-dihydroxyvitamin d3 191-220 interferon gamma Homo sapiens 261-270 7925931-5 1994 In humans, interferon-gamma induces the release of neopterin and 7,8-dihydroneopterin and also the synthesis of nitric oxide radical which in turn stimulate the formation of cGMP. Neopterin 51-60 interferon gamma Homo sapiens 11-27 7925931-5 1994 In humans, interferon-gamma induces the release of neopterin and 7,8-dihydroneopterin and also the synthesis of nitric oxide radical which in turn stimulate the formation of cGMP. 7,8-dihydroneopterin 65-85 interferon gamma Homo sapiens 11-27 7925931-5 1994 In humans, interferon-gamma induces the release of neopterin and 7,8-dihydroneopterin and also the synthesis of nitric oxide radical which in turn stimulate the formation of cGMP. nitric oxide radical 112-132 interferon gamma Homo sapiens 11-27 7925931-5 1994 In humans, interferon-gamma induces the release of neopterin and 7,8-dihydroneopterin and also the synthesis of nitric oxide radical which in turn stimulate the formation of cGMP. Cyclic GMP 174-178 interferon gamma Homo sapiens 11-27 7850545-13 1994 CONCLUSIONS: This IFN-gamma-mediated decrease in glutaminase activity may be one mechanism by which gut glutamine metabolism is diminished as the tumor grows and becomes the principal organ of glutamine use. Glutamine 104-113 interferon gamma Homo sapiens 18-27 8093077-7 1994 PUVA treatment of HUT-78 cells resulted in an increase in IFN gamma mRNA level from 32 to 80 pg/microgram of total RNA, suggesting that PUVA induces transcription of T-helper 1 cytokines as part of its mechanism of action. puva 0-4 interferon gamma Homo sapiens 58-67 7850545-13 1994 CONCLUSIONS: This IFN-gamma-mediated decrease in glutaminase activity may be one mechanism by which gut glutamine metabolism is diminished as the tumor grows and becomes the principal organ of glutamine use. Glutamine 193-202 interferon gamma Homo sapiens 18-27 8069926-4 1994 In this report, we show that the IFN-gamma-dependent inhibition of IL-8 release by PMN stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF), and/or interleukin-1 beta (IL-1 beta), but not with Y-IgG, is a transient phenomenon. y-igg 210-215 interferon gamma Homo sapiens 33-42 8080246-2 1994 By adopting in situ hybridization with complementary DNA oligonucleotide probes for human IFN-gamma IL-4, and TGF-beta, the expression of mRNA for these cytokines was detected in mononuclear cells (MNC) from blood and cerebrospinal fluids. Oligonucleotides 57-72 interferon gamma Homo sapiens 90-99 7827285-5 1994 TNF, IFN-alpha and IFN-gamma decreased fatty acid synthesis while IL-1 increased fatty acid synthesis. Fatty Acids 39-49 interferon gamma Homo sapiens 19-28 8082304-3 1994 Children with atopic dermatitis were found to have constitutive expression of IFN-gamma mRNA in freshly isolated peripheral blood mononuclear cells (PBMC) and in unstimulated PBMC cultures which increased further following stimulation with phorbol myristate acetate (PMA)/Ca in vitro. Tetradecanoylphorbol Acetate 240-265 interferon gamma Homo sapiens 78-87 8082304-3 1994 Children with atopic dermatitis were found to have constitutive expression of IFN-gamma mRNA in freshly isolated peripheral blood mononuclear cells (PBMC) and in unstimulated PBMC cultures which increased further following stimulation with phorbol myristate acetate (PMA)/Ca in vitro. Tetradecanoylphorbol Acetate 267-270 interferon gamma Homo sapiens 78-87 7827285-8 1994 In addition, while TNF, IFN-alpha and IFN-gamma decreased fatty acid synthesis, only TNF significantly decreased the mRNA levels of both acetyl CoA carboxylase and fatty acid synthase, the key enzymes in fatty acid synthesis. Fatty Acids 58-68 interferon gamma Homo sapiens 38-47 7520418-1 1994 Lymphoproliferation and gamma interferon (IFN-gamma) secretion in response to 28 overlapping 20-mer synthetic peptides covering the complete sequence of the mature (295-amino-acid) 85A component of the major secreted, fibronectin-binding antigen 85 complex from Mycobacterium tuberculosis and Mycobacterium bovis BCG (MTAg85A) was examined by using peripheral blood mononuclear cell (PBMC) cultures from healthy tuberculin- and lepromin-positive volunteers and from patients with tuberculosis and leprosy. Peptides 110-118 interferon gamma Homo sapiens 42-51 8063424-5 1994 Both spontaneous inhibition and IFN-gamma-induced inhibition of Plasmodium yoelii-infected murine hepatocytes were increased with the addition of the NO synthase cofactor tetrahydrobiopterin, or sepiapterin, which is converted to tetrahydrobiopterin. sapropterin 171-190 interferon gamma Homo sapiens 32-41 8063424-5 1994 Both spontaneous inhibition and IFN-gamma-induced inhibition of Plasmodium yoelii-infected murine hepatocytes were increased with the addition of the NO synthase cofactor tetrahydrobiopterin, or sepiapterin, which is converted to tetrahydrobiopterin. sepiapterin 195-206 interferon gamma Homo sapiens 32-41 8063424-5 1994 Both spontaneous inhibition and IFN-gamma-induced inhibition of Plasmodium yoelii-infected murine hepatocytes were increased with the addition of the NO synthase cofactor tetrahydrobiopterin, or sepiapterin, which is converted to tetrahydrobiopterin. sapropterin 230-249 interferon gamma Homo sapiens 32-41 7530231-4 1994 The present data also indicated that addition of Interleukin-4 generally resulted in an increased nitrite production, that was potentiated by IFN-gamma, inactive alone. Nitrites 98-105 interferon gamma Homo sapiens 142-151 7824050-6 1994 This effect of IFN-gamma, but not that of IFN-alpha 2b was antagonized by suramin. Suramin 74-81 interferon gamma Homo sapiens 15-24 8090031-8 1994 On treatment with various biomodulators, only all-trans retinoic acid significantly upregulated MSE message and protein levels but could not induce new MSE expression in several leukemia cell lines; lipopolysaccharide and interferon-gamma increased MSE expression in normal monocytes. Tretinoin 56-69 interferon gamma Homo sapiens 222-238 8049434-5 1994 Of various cytokines tested, tumor necrosis factor-alpha (TNF-alpha) alone counteracted GM2- and GM3-induced inhibitions of Ig production and thymidine uptake, whereas other cytokines including IL-1 beta, IL-3, IL-5, IL-6, and interferon-gamma each failed to do so. gm2 88-91 interferon gamma Homo sapiens 227-243 7521164-6 1994 Genistein also modulates the expression of ICAM-1 on endothelial cells by potentiating the upregulating effect of TNF and IFN-gamma. Genistein 0-9 interferon gamma Homo sapiens 122-131 7914514-0 1994 Interferon gamma-induced reduction in erbB-2 tyrosyl phosphorylation in human ovarian carcinoma cells. cyclo(tyrosyl-tyrosyl) 45-52 interferon gamma Homo sapiens 0-16 7914514-2 1994 We now show that interferon-gamma (IFN-gamma) also decreases constitutive tyrosine phosphorylation of erbB-2 and inhibits erbB-2 kinase activity in an ovarian cancer cell line. Tyrosine 74-82 interferon gamma Homo sapiens 17-33 7914514-2 1994 We now show that interferon-gamma (IFN-gamma) also decreases constitutive tyrosine phosphorylation of erbB-2 and inhibits erbB-2 kinase activity in an ovarian cancer cell line. Tyrosine 74-82 interferon gamma Homo sapiens 35-44 8065917-4 1994 Here we show by in vivo footprinting using dimethylsulfate (DMS) that the GAS of the IRF-1 promoter, which also contains an overlapping putative NF-kappa B site, is occupied upon treatment with gamma-interferon (IFN gamma) but not with phorbol 12-myristate 13-acetate (PMA). dimethyl sulfate 43-58 interferon gamma Homo sapiens 212-221 8065917-4 1994 Here we show by in vivo footprinting using dimethylsulfate (DMS) that the GAS of the IRF-1 promoter, which also contains an overlapping putative NF-kappa B site, is occupied upon treatment with gamma-interferon (IFN gamma) but not with phorbol 12-myristate 13-acetate (PMA). dimethyl sulfate 60-63 interferon gamma Homo sapiens 212-221 8065917-4 1994 Here we show by in vivo footprinting using dimethylsulfate (DMS) that the GAS of the IRF-1 promoter, which also contains an overlapping putative NF-kappa B site, is occupied upon treatment with gamma-interferon (IFN gamma) but not with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 236-267 interferon gamma Homo sapiens 212-221 8049434-5 1994 Of various cytokines tested, tumor necrosis factor-alpha (TNF-alpha) alone counteracted GM2- and GM3-induced inhibitions of Ig production and thymidine uptake, whereas other cytokines including IL-1 beta, IL-3, IL-5, IL-6, and interferon-gamma each failed to do so. gm3 97-100 interferon gamma Homo sapiens 227-243 8074189-8 1994 Together, these results strongly suggest that insulin, insulin-like growth factors, and interferon-gamma increase the permeability across T84 cell monolayers through a common mechanism that is modulated by glucose-derived metabolites and oxidative metabolism. Glucose 206-213 interferon gamma Homo sapiens 88-104 8074176-7 1994 [3H]bumetanide binding assays suggested that surface expression of the cotransporter was diminished by > 70% after IFN-gamma preexposure. Tritium 1-3 interferon gamma Homo sapiens 118-127 7913411-3 1994 In the present study, we investigated the role of calcium (Ca2+) and calmodulin (CaM) in the retinoic acid and gamma-interferon (IFN-gamma) signaling in the human neuroblastoma cell line SK-N-SH for up-regulating ICAM-1 expression. Calcium 50-57 interferon gamma Homo sapiens 129-138 8074176-7 1994 [3H]bumetanide binding assays suggested that surface expression of the cotransporter was diminished by > 70% after IFN-gamma preexposure. Bumetanide 4-14 interferon gamma Homo sapiens 118-127 8082110-2 1994 Neopterin, which is produced by activated macrophages under the control of interferon-gamma, is one of the indices of immune activation. Neopterin 0-9 interferon gamma Homo sapiens 75-91 8044830-0 1994 Effect of interferon gamma and tumour necrosis factor alpha on sensitivity to cisplatin in ovarian carcinoma cell lines. Cisplatin 78-87 interferon gamma Homo sapiens 10-26 8044830-1 1994 This study aimed to investigate whether the biological response modifiers (BRM) interferon gamma (IFN gamma) and tumour necrosis factor alpha (TNF alpha) could enhance the cytotoxic action of cisplatin on ovarian tumour cells in vitro. Cisplatin 192-201 interferon gamma Homo sapiens 80-96 8044830-1 1994 This study aimed to investigate whether the biological response modifiers (BRM) interferon gamma (IFN gamma) and tumour necrosis factor alpha (TNF alpha) could enhance the cytotoxic action of cisplatin on ovarian tumour cells in vitro. Cisplatin 192-201 interferon gamma Homo sapiens 98-107 8044830-4 1994 When IFN gamma was used in combination with cisplatin, a significant enhancement of cisplatin toxicity occurred in three of four cell lines. Cisplatin 84-93 interferon gamma Homo sapiens 5-14 8044830-7 1994 However, in one cell line at least (PEO1), both TNF alpha and IFN gamma demonstrated a clearly synergistic effect with cisplatin. Cisplatin 119-128 interferon gamma Homo sapiens 62-71 8088386-0 1994 Interferon-gamma modulates cytosolic free calcium in human neutrophilic granulocytes. Calcium 42-49 interferon gamma Homo sapiens 0-16 8056032-2 1994 The current report confirms that anti-TNF-alpha does inhibit activation of interferon-gamma (IFN-gamma)-primed Mphi by paraformaldehyde-fixed activated T cells. paraform 119-135 interferon gamma Homo sapiens 75-91 8056032-2 1994 The current report confirms that anti-TNF-alpha does inhibit activation of interferon-gamma (IFN-gamma)-primed Mphi by paraformaldehyde-fixed activated T cells. paraform 119-135 interferon gamma Homo sapiens 93-102 8088386-1 1994 To investigate the role of cytosolic free calcium ([Ca2+]i in interferon-gamma (IFN-gamma) pre-activation (priming) of human neutrophilic granulocytes (PMN) we used three different fluorescence methods, i.e. digital imaging of single, adherent, Fura-2 loaded cells, flow cytometric measurements of single, non-adherent, Fluo-3 loaded cells, and spectrofluorometry of Indo-1 loaded PMN in suspension. Calcium 42-49 interferon gamma Homo sapiens 62-78 8088386-7 1994 We suggest that IFN-gamma increases the plasma membrane permeability for calcium in PMN, and substantiate this by demonstrating compliance with a capacitative model for intracellular calcium regulation. Calcium 73-80 interferon gamma Homo sapiens 16-25 8088386-7 1994 We suggest that IFN-gamma increases the plasma membrane permeability for calcium in PMN, and substantiate this by demonstrating compliance with a capacitative model for intracellular calcium regulation. Calcium 183-190 interferon gamma Homo sapiens 16-25 7913937-8 1994 The appearance of HLA-DR induced by IFN gamma was accompanied by a progressive reduction of TPO despite stimulation by TSH or TSab. Thyrotropin 119-122 interferon gamma Homo sapiens 36-45 8064074-8 1994 Peripheral blood mononuclear cells obtained from patients before and after administration of prednisone revealed a significant decrease in interferon-gamma synthesis (p = 0.005), but not in interleukin-4 (p = 0.6), after the course of prednisone. Prednisone 93-103 interferon gamma Homo sapiens 139-155 8064074-8 1994 Peripheral blood mononuclear cells obtained from patients before and after administration of prednisone revealed a significant decrease in interferon-gamma synthesis (p = 0.005), but not in interleukin-4 (p = 0.6), after the course of prednisone. Prednisone 235-245 interferon gamma Homo sapiens 139-155 7929850-6 1994 The most sensitive IFN-gamma detection was achieved by the combination of bead with acridinium ester. 9-Phenylcarboxylate-10-methylacridinium 84-100 interferon gamma Homo sapiens 19-28 7913937-8 1994 The appearance of HLA-DR induced by IFN gamma was accompanied by a progressive reduction of TPO despite stimulation by TSH or TSab. tsab 126-130 interferon gamma Homo sapiens 36-45 8021490-2 1994 Published reports show that human T lymphocytes and monocytes also release 5HT after stimulation with PHA or IFN-gamma. Serotonin 75-78 interferon gamma Homo sapiens 109-118 8027555-8 1994 Fc gamma RIII protein expression was detected after LPS/IFN-gamma stimulation both by specific staining of paraformaldehyde-fixed HMC and immunoprecipitation of Fc gamma RIII protein from HMC membranes. paraform 107-123 interferon gamma Homo sapiens 56-65 7913877-6 1994 When actinomycin D (a protein synthesis inhibitor) was added to the culture medium prior to treatment with IFN gamma and TNF, the LAK sensitivity of SMKT-R-3 recovered to the level demonstrated by the cells that had not received any cytokine treatment. Dactinomycin 5-18 interferon gamma Homo sapiens 107-116 7954708-3 1994 Initial release of calcium from stores following Fc gamma R cross-linking is enhanced by prior treatment of U937 cells with both interferon-gamma, and, to a lesser extent, with dibutyryl cAMP. Calcium 19-26 interferon gamma Homo sapiens 129-145 7954708-4 1994 A large and prolonged entry of external calcium is observed in dibutyryl cAMP treated cells; this may be due to direct regulation of calcium channels by the low affinity receptor, Fc gamma RII (whose expression is up-regulated in these cells), since the smaller and more transient entry observed in interferon-gamma treated cells, (where the high affinity receptor, Fc gamma RI, is up-regulated) argues against a common pathway of store-mediated calcium entry. Calcium 40-47 interferon gamma Homo sapiens 299-315 7954708-4 1994 A large and prolonged entry of external calcium is observed in dibutyryl cAMP treated cells; this may be due to direct regulation of calcium channels by the low affinity receptor, Fc gamma RII (whose expression is up-regulated in these cells), since the smaller and more transient entry observed in interferon-gamma treated cells, (where the high affinity receptor, Fc gamma RI, is up-regulated) argues against a common pathway of store-mediated calcium entry. dibutyryl 63-72 interferon gamma Homo sapiens 299-315 7954708-4 1994 A large and prolonged entry of external calcium is observed in dibutyryl cAMP treated cells; this may be due to direct regulation of calcium channels by the low affinity receptor, Fc gamma RII (whose expression is up-regulated in these cells), since the smaller and more transient entry observed in interferon-gamma treated cells, (where the high affinity receptor, Fc gamma RI, is up-regulated) argues against a common pathway of store-mediated calcium entry. Cyclic AMP 73-77 interferon gamma Homo sapiens 299-315 7954708-4 1994 A large and prolonged entry of external calcium is observed in dibutyryl cAMP treated cells; this may be due to direct regulation of calcium channels by the low affinity receptor, Fc gamma RII (whose expression is up-regulated in these cells), since the smaller and more transient entry observed in interferon-gamma treated cells, (where the high affinity receptor, Fc gamma RI, is up-regulated) argues against a common pathway of store-mediated calcium entry. Calcium 133-140 interferon gamma Homo sapiens 299-315 7519528-11 1994 RESULTS: After 4-6 weeks of FK-506 therapy, human IgG, all thyroid antibodies and IFN-gamma were suppressed, while the levels remained elevated in the control group. Tacrolimus 28-34 interferon gamma Homo sapiens 82-91 7947460-2 1994 We have previously reported that allergen-specific CD4+ Th2 T cell clones produce IFN-gamma, following activation by phorbol ester (TPA) and calcium ionophore, indicating that these cells still have the ability to produce IFN-gamma. Phorbol Esters 117-130 interferon gamma Homo sapiens 82-91 7919237-4 1994 Timed incubation of the blasts in RPMI-1640/FCS or serum-free medium "spontaneously" increased the percentage of CD 54 positive cells in 11/13 cases with a main increase after 24 h. IFN-gamma (500 IU/ml) further enhanced CD 54 positivity in 6/11 cases. rpmi-1640 34-43 interferon gamma Homo sapiens 182-191 7947460-2 1994 We have previously reported that allergen-specific CD4+ Th2 T cell clones produce IFN-gamma, following activation by phorbol ester (TPA) and calcium ionophore, indicating that these cells still have the ability to produce IFN-gamma. Tetradecanoylphorbol Acetate 132-135 interferon gamma Homo sapiens 82-91 7947460-4 1994 Activation with antigen or TPA/anti-CD3 mAb of Th2 T cell clones that had been preincubated with rIL-12 and rIL-2 for 5 days induced or enhanced the expression of IFN-gamma transcripts, as well as the production of IFN-gamma by these cells. Tetradecanoylphorbol Acetate 27-30 interferon gamma Homo sapiens 163-172 7947460-4 1994 Activation with antigen or TPA/anti-CD3 mAb of Th2 T cell clones that had been preincubated with rIL-12 and rIL-2 for 5 days induced or enhanced the expression of IFN-gamma transcripts, as well as the production of IFN-gamma by these cells. Tetradecanoylphorbol Acetate 27-30 interferon gamma Homo sapiens 215-224 7947460-4 1994 Activation with antigen or TPA/anti-CD3 mAb of Th2 T cell clones that had been preincubated with rIL-12 and rIL-2 for 5 days induced or enhanced the expression of IFN-gamma transcripts, as well as the production of IFN-gamma by these cells. ril-12 97-103 interferon gamma Homo sapiens 163-172 7947460-4 1994 Activation with antigen or TPA/anti-CD3 mAb of Th2 T cell clones that had been preincubated with rIL-12 and rIL-2 for 5 days induced or enhanced the expression of IFN-gamma transcripts, as well as the production of IFN-gamma by these cells. ril-12 97-103 interferon gamma Homo sapiens 215-224 7947460-5 1994 Furthermore, in a different set of experiments, it was found that the presence of rIL-12 during a 12 h stimulation of Th2 T cell clones induced or enhanced the expression of IFN-gamma transcripts, as well as the production of IFN-gamma by these cells. ril-12 82-88 interferon gamma Homo sapiens 174-183 7947460-5 1994 Furthermore, in a different set of experiments, it was found that the presence of rIL-12 during a 12 h stimulation of Th2 T cell clones induced or enhanced the expression of IFN-gamma transcripts, as well as the production of IFN-gamma by these cells. ril-12 82-88 interferon gamma Homo sapiens 226-235 7947460-6 1994 rIL-12 also enhanced IFN-gamma production by Th0 and Th1 T cells, but, in contrast, rIL-12 had no effect on the production of IL-4, nor on the frequency of IL-4 producing cells, as judged by analysis of intracellularly produced cytokines. ril-12 0-6 interferon gamma Homo sapiens 21-30 8027254-2 1994 The antiviral activity of recombinant (r) hIFN gamma, estimated by inhibition of vesicular stomatitis virus yield, was potentiated up to 120-fold in human fibroblast (BG-9) cells exposed to free L-T4 (0.5 x 10(-10) mol/L). Thyroxine 195-199 interferon gamma Homo sapiens 42-52 8021937-0 1994 The influence of adenine-rich motifs in the 3" portion of the ribosome binding site on human IFN-gamma gene expression in Escherichia coli. Adenine 17-24 interferon gamma Homo sapiens 93-102 7913474-8 1994 Serum and CSF levels of sICAM-1 correlated with neopterin levels, a marker of interferon-gamma-mediated macrophage activation and CSF sICAM-1 levels were inversely correlated to numbers of CD4+ T cells. Neopterin 48-57 interferon gamma Homo sapiens 78-94 8207247-2 1994 The fluorinated 4-quinolone, ciprofloxacin, for example, up-regulates IL-2 and IFN-gamma production in PBLs stimulated in vitro. 4-Quinolones 16-27 interferon gamma Homo sapiens 79-88 8207247-2 1994 The fluorinated 4-quinolone, ciprofloxacin, for example, up-regulates IL-2 and IFN-gamma production in PBLs stimulated in vitro. Ciprofloxacin 29-42 interferon gamma Homo sapiens 79-88 8207247-3 1994 In the present study, ciprofloxacin was shown to increase the levels of mRNA for IL-1 alpha, IL-2 and its receptor, IFN-gamma, IL-3, IL-4, granulocyte-macrophage/CSF, TNF-alpha, and lymphotoxin. Ciprofloxacin 22-35 interferon gamma Homo sapiens 116-125 7936131-6 1994 Treatment with antisense-intercellular-adhesion molecule-1 oligonucleotide further inhibited LAK lysis of target cells, following treatment with IFN-gamma. Oligonucleotides 59-74 interferon gamma Homo sapiens 145-154 8016072-3 1994 To understand the relationship between the solution form of IFN-gamma and the moiety that actually binds to the cellular receptor and activates cells, we examined irradiated nonradioactive and 32P-labeled IFN-gamma for its migration in SDS/polyacrylamide gels (to determine its physical integrity), its binding to cells, its reactivity in an ELISA, and its antiviral activity. Phosphorus-32 193-196 interferon gamma Homo sapiens 205-214 7524887-6 1994 However, as well as showing inhibitory effects, IFN-gamma increased the number of pure and mixed megakaryocyte colonies formed by post-5-fluorouracil treated bone marrow cells and, moreover, the addition of IFN-gamma to culture containing stem cell factor resulted in a synergistic effect on the development of both primitive hematopoietic progenitors and mature populations. Fluorouracil 135-149 interferon gamma Homo sapiens 48-57 7805562-0 1994 [Modulation effect of cimetidine on the production of IL-2 and interferon-gamma in patients with gastric cancer]. Cimetidine 22-32 interferon gamma Homo sapiens 63-79 7805562-1 1994 The modulation effects of cimetidine on the production of IL-2 and IFN-gamma by the peripheral blood mononuclear cells in 31 patients with gastric cancer and 32 normal subjects were studied. Cimetidine 26-36 interferon gamma Homo sapiens 67-76 7805562-4 1994 Cimetidine could significantly promote IL-2 and IFN-gamma production. Cimetidine 0-10 interferon gamma Homo sapiens 48-57 8016072-3 1994 To understand the relationship between the solution form of IFN-gamma and the moiety that actually binds to the cellular receptor and activates cells, we examined irradiated nonradioactive and 32P-labeled IFN-gamma for its migration in SDS/polyacrylamide gels (to determine its physical integrity), its binding to cells, its reactivity in an ELISA, and its antiviral activity. Sodium Dodecyl Sulfate 236-239 interferon gamma Homo sapiens 60-69 8016072-3 1994 To understand the relationship between the solution form of IFN-gamma and the moiety that actually binds to the cellular receptor and activates cells, we examined irradiated nonradioactive and 32P-labeled IFN-gamma for its migration in SDS/polyacrylamide gels (to determine its physical integrity), its binding to cells, its reactivity in an ELISA, and its antiviral activity. Sodium Dodecyl Sulfate 236-239 interferon gamma Homo sapiens 205-214 8206916-8 1994 This metal complex lacks the ability to interact with the interferon-gamma receptor. Metals 5-10 interferon gamma Homo sapiens 58-74 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 127-133 interferon gamma Homo sapiens 23-39 8003066-10 1994 Inhibition of prostaglandin production by antiinflammatory agents might restore TH1 responses with local production of IL-2 and IFN gamma. Prostaglandins 14-27 interferon gamma Homo sapiens 128-137 8003068-7 1994 DP (3 micrograms/ml) significantly suppressed IFN gamma production by immobilized anti-CD3-stimulated CD4+ T cells, but not IgM production induced by SAC + IL-2 stimulation. Penicillamine 0-2 interferon gamma Homo sapiens 46-55 7520304-12 1994 Unpublished studies suggest that the steroids prednisolone and dexamethasone can synergize in vitro with suboptimal concentrations of interferon-gamma (IFN-gamma) to promote the activation of human endothelial cell lines, as manifested by enhanced expression of MHC class II but not ICAM-1. Prednisolone 46-58 interferon gamma Homo sapiens 134-150 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 127-133 interferon gamma Homo sapiens 41-50 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 178-184 interferon gamma Homo sapiens 23-39 8004823-4 1994 IL-1 alpha (100 U/ml), interferon-gamma (IFN-gamma) (10 U/ml), and indomethacin (2 microM) were found to significantly enhance nickel-induced proliferation in PBMC cultures from nickel-hypersensitive donors (n = 6). Nickel 178-184 interferon gamma Homo sapiens 41-50 7523670-2 1994 Interferon gamma (IFN-gamma) has antitumor cell activity related to stimulation of 2,3 indoleamine dioxygenase (IDO), a widely distributed tryptophan catabolizing enzyme. Tryptophan 139-149 interferon gamma Homo sapiens 0-16 21567038-0 1994 Sensitivity of drug-resistant B-cell lines from AIDS-related non-hodgkins-lymphoma to newly synthesized podophyllotoxin derivatives and aza-alkyllysophospholipids - enhanced sensitization by pretreatment with interferon-gamma. podophyllotoxin derivatives 104-131 interferon gamma Homo sapiens 209-225 21567038-0 1994 Sensitivity of drug-resistant B-cell lines from AIDS-related non-hodgkins-lymphoma to newly synthesized podophyllotoxin derivatives and aza-alkyllysophospholipids - enhanced sensitization by pretreatment with interferon-gamma. aza-alkyllysophospholipids 136-162 interferon gamma Homo sapiens 209-225 21567038-9 1994 In all cases, the sensitivity of the IFN-gamma pretreated cell lines to the podophyllotoxin derivatives and AALP was significantly enhanced. Podophyllotoxin 76-91 interferon gamma Homo sapiens 37-46 7910619-8 1994 Addition of rIL-12 to keratinocyte-supported cultures restores IFN-gamma levels to those seen when professional APCs are present. ril-12 12-18 interferon gamma Homo sapiens 63-72 7514165-0 1994 Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor. Tyrosine 25-33 interferon gamma Homo sapiens 0-16 7514165-0 1994 Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor. Tyrosine 25-33 interferon gamma Homo sapiens 53-69 7514165-1 1994 Interferon-gamma (IFN-gamma) induces the expression of a set of early response genes by tyrosine phosphorylation of latent transcription factors such as p91. Tyrosine 88-96 interferon gamma Homo sapiens 0-16 7514165-1 1994 Interferon-gamma (IFN-gamma) induces the expression of a set of early response genes by tyrosine phosphorylation of latent transcription factors such as p91. Tyrosine 88-96 interferon gamma Homo sapiens 18-27 7514165-3 1994 H2O2/vanadate treatment of cells for 15 min resulted in only the tyrosine phosphorylation of Jak1 and IFN-gamma R. Only after 60 min of this treatment did we observe tyrosine phosphorylation of Jak2 and p91 and assembly of the transcription factor complex FcRF gamma that binds to the promoter of the fcgr1 gene. Hydrogen Peroxide 0-4 interferon gamma Homo sapiens 102-111 7514165-3 1994 H2O2/vanadate treatment of cells for 15 min resulted in only the tyrosine phosphorylation of Jak1 and IFN-gamma R. Only after 60 min of this treatment did we observe tyrosine phosphorylation of Jak2 and p91 and assembly of the transcription factor complex FcRF gamma that binds to the promoter of the fcgr1 gene. Vanadates 5-13 interferon gamma Homo sapiens 102-111 7514170-0 1994 Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-gamma primed mononuclear phagocytes. Nitric Oxide 0-12 interferon gamma Homo sapiens 62-78 7514170-3 1994 Authentic NO gas or the NO-generating compound, diethylamine dinitric oxide adduct, dose-dependently inhibited IDO activity in cell lysates prepared from IFN gamma-primed human peripheral blood mononuclear cells, as assessed by the ascorbate/methylene blue assay for IDO. 1,1-diethyl-2-hydroxy-2-nitrosohydrazine 48-75 interferon gamma Homo sapiens 154-163 7514170-3 1994 Authentic NO gas or the NO-generating compound, diethylamine dinitric oxide adduct, dose-dependently inhibited IDO activity in cell lysates prepared from IFN gamma-primed human peripheral blood mononuclear cells, as assessed by the ascorbate/methylene blue assay for IDO. Ascorbic Acid 232-241 interferon gamma Homo sapiens 154-163 7514170-3 1994 Authentic NO gas or the NO-generating compound, diethylamine dinitric oxide adduct, dose-dependently inhibited IDO activity in cell lysates prepared from IFN gamma-primed human peripheral blood mononuclear cells, as assessed by the ascorbate/methylene blue assay for IDO. Methylene Blue 242-256 interferon gamma Homo sapiens 154-163 7514170-8 1994 In contrast to human cells, addition of IFN gamma to murine macrophages, cultured in complete RPMI 1640 medium, readily induced nitric oxide synthase. rpmi 1640 medium 94-110 interferon gamma Homo sapiens 40-49 7523670-2 1994 Interferon gamma (IFN-gamma) has antitumor cell activity related to stimulation of 2,3 indoleamine dioxygenase (IDO), a widely distributed tryptophan catabolizing enzyme. Tryptophan 139-149 interferon gamma Homo sapiens 18-27 7514170-11 1994 Together, these results demonstrate that both exogenous and endogenous NO inhibit IDO activity and that oxidative arginine and tryptophan metabolism in IFN gamma-primed mononuclear phagocytes are functionally related. Arginine 114-122 interferon gamma Homo sapiens 152-161 7523670-5 1994 RESULTS: In fresh and in > or = 2 month-old cultures, IFN-gamma strongly stimulated IDO activity, a corresponding fall in supernatant tryptophan levels, and an elevation in the supernatant concentration of kynurenine, tryptophan"s principal metabolite, mRNA for IDO was likewise markedly increased in cells after 4 days" incubation with IFN-gamma. Tryptophan 137-147 interferon gamma Homo sapiens 57-66 7514170-11 1994 Together, these results demonstrate that both exogenous and endogenous NO inhibit IDO activity and that oxidative arginine and tryptophan metabolism in IFN gamma-primed mononuclear phagocytes are functionally related. Tryptophan 127-137 interferon gamma Homo sapiens 152-161 7523670-5 1994 RESULTS: In fresh and in > or = 2 month-old cultures, IFN-gamma strongly stimulated IDO activity, a corresponding fall in supernatant tryptophan levels, and an elevation in the supernatant concentration of kynurenine, tryptophan"s principal metabolite, mRNA for IDO was likewise markedly increased in cells after 4 days" incubation with IFN-gamma. Kynurenine 209-219 interferon gamma Homo sapiens 57-66 7523670-5 1994 RESULTS: In fresh and in > or = 2 month-old cultures, IFN-gamma strongly stimulated IDO activity, a corresponding fall in supernatant tryptophan levels, and an elevation in the supernatant concentration of kynurenine, tryptophan"s principal metabolite, mRNA for IDO was likewise markedly increased in cells after 4 days" incubation with IFN-gamma. Kynurenine 209-219 interferon gamma Homo sapiens 340-349 7523670-5 1994 RESULTS: In fresh and in > or = 2 month-old cultures, IFN-gamma strongly stimulated IDO activity, a corresponding fall in supernatant tryptophan levels, and an elevation in the supernatant concentration of kynurenine, tryptophan"s principal metabolite, mRNA for IDO was likewise markedly increased in cells after 4 days" incubation with IFN-gamma. Tryptophan 221-231 interferon gamma Homo sapiens 57-66 7523670-10 1994 CONCLUSIONS: IFN-gamma stimulates IDO production and tryptophan metabolism in cultured human synovial cells, and therefore may contribute to this cytokine"s in vitro and clinical effects in arthritis and inflammation. Tryptophan 53-63 interferon gamma Homo sapiens 13-22 7909823-6 1994 Primed cells are enriched in CD45R0hi and CD31- cells, and upon stimulation with PMA+ ionomycin they release significant amounts of IL-2, IFN-gamma, IL-4, IL-5, and IL-10. Tetradecanoylphorbol Acetate 81-84 interferon gamma Homo sapiens 138-147 8176225-6 1994 The increase in hPAF-R expression was associated with an augmented response of IFN-gamma-treated cells to PAF in terms of cytosolic calcium ([Ca2+]i) variations. Platelet Activating Factor 17-20 interferon gamma Homo sapiens 79-88 8176225-6 1994 The increase in hPAF-R expression was associated with an augmented response of IFN-gamma-treated cells to PAF in terms of cytosolic calcium ([Ca2+]i) variations. Calcium 132-139 interferon gamma Homo sapiens 79-88 8176225-8 1994 Pretreatment of monocytes with actinomycin D, however, completely abrogated the effect of IFN-gamma, suggesting a transcriptional regulation. Dactinomycin 31-44 interferon gamma Homo sapiens 90-99 7908719-9 1994 RESULTS: In response to phytohemagglutinin, the production of interferon gamma by mononuclear cells from the patients was lower than in normal subjects (P < 0.001), whereas stimulation with ionomycin and phorbol myristate acetate led to normal production of interferon gamma in the patients. Ionomycin 193-202 interferon gamma Homo sapiens 62-78 7908719-9 1994 RESULTS: In response to phytohemagglutinin, the production of interferon gamma by mononuclear cells from the patients was lower than in normal subjects (P < 0.001), whereas stimulation with ionomycin and phorbol myristate acetate led to normal production of interferon gamma in the patients. Ionomycin 193-202 interferon gamma Homo sapiens 261-277 7908719-9 1994 RESULTS: In response to phytohemagglutinin, the production of interferon gamma by mononuclear cells from the patients was lower than in normal subjects (P < 0.001), whereas stimulation with ionomycin and phorbol myristate acetate led to normal production of interferon gamma in the patients. Tetradecanoylphorbol Acetate 207-232 interferon gamma Homo sapiens 62-78 7909823-6 1994 Primed cells are enriched in CD45R0hi and CD31- cells, and upon stimulation with PMA+ ionomycin they release significant amounts of IL-2, IFN-gamma, IL-4, IL-5, and IL-10. Ionomycin 86-95 interferon gamma Homo sapiens 138-147 8192669-2 1994 Whereas IFN gamma alone did not enhance phosphorylation of the IFN gamma receptor, treatment of monocytes with the Ser/Thr phosphatase inhibitors, okadaic acid and calyculin A, resulted in increased phosphorylation of the IFN gamma receptor. calyculin A 164-175 interferon gamma Homo sapiens 63-72 8192669-2 1994 Whereas IFN gamma alone did not enhance phosphorylation of the IFN gamma receptor, treatment of monocytes with the Ser/Thr phosphatase inhibitors, okadaic acid and calyculin A, resulted in increased phosphorylation of the IFN gamma receptor. calyculin A 164-175 interferon gamma Homo sapiens 63-72 8192669-4 1994 Using three IFN gamma-induced early-response genes, IP-10, the Fc gamma receptor type I (Fc gamma RI) and ISG-54, we found selective sensitivity to pretreatment with okadaic acid and calyculin A. Okadaic Acid 166-178 interferon gamma Homo sapiens 12-21 7514190-6 1994 Combinations of cytokines, notably IL-1 beta plus IFN-gamma plus TNF-alpha, induced increased expression of inducible NO synthase mRNA after 6 h and resulted in a fivefold increase in medium nitrite accumulation after 48 h. These cytokines did not impair glucose metabolism or insulin release in response to 16.7 mM glucose, but there was an 80% decrease in islet insulin content. Nitrites 191-198 interferon gamma Homo sapiens 50-59 7947242-2 1994 The addition of IFN-gamma to either unstimulated or cobalt chloride (CoCl2)-treated Hep3B cells resulted in a dose-dependent inhibition of Epo release in the medium by as much as 70% at 1000 U/ml. cobaltous chloride 52-67 interferon gamma Homo sapiens 16-25 7947242-2 1994 The addition of IFN-gamma to either unstimulated or cobalt chloride (CoCl2)-treated Hep3B cells resulted in a dose-dependent inhibition of Epo release in the medium by as much as 70% at 1000 U/ml. cobaltous chloride 69-74 interferon gamma Homo sapiens 16-25 7947242-4 1994 According to previous observations, IL-6 had a stimulatory effect on Epo production by CoCl2-treated Hep3B cells; however, the simultaneous addition of IFN-gamma and IL-6 resulted in a reversal of the stimulatory effects due to IL-6. cobaltous chloride 87-92 interferon gamma Homo sapiens 152-161 7947242-6 1994 The inhibitory effect of IFN-gamma appeared to be due to a down-modulation of Epo mRNA levels in CoCl2-treated Hep3B cells, as shown by Northern blot analysis. cobaltous chloride 97-102 interferon gamma Homo sapiens 25-34 7514190-6 1994 Combinations of cytokines, notably IL-1 beta plus IFN-gamma plus TNF-alpha, induced increased expression of inducible NO synthase mRNA after 6 h and resulted in a fivefold increase in medium nitrite accumulation after 48 h. These cytokines did not impair glucose metabolism or insulin release in response to 16.7 mM glucose, but there was an 80% decrease in islet insulin content. Glucose 255-262 interferon gamma Homo sapiens 50-59 7514193-3 1994 24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline. Carbon-14 151-154 interferon gamma Homo sapiens 20-29 7514193-3 1994 24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline. Arginine 155-165 interferon gamma Homo sapiens 20-29 7514193-3 1994 24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline. Carbon-14 170-173 interferon gamma Homo sapiens 20-29 7514193-3 1994 24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline. Citrulline 174-186 interferon gamma Homo sapiens 20-29 7514193-8 1994 IFN-gamma plus TNF or IL-1 beta increased endogenous tetrahydrobiopterin levels and GTP cyclohydrolase I activity, the rate-limiting enzyme of tetrahydrobiopterin synthesis. sapropterin 53-72 interferon gamma Homo sapiens 0-9 7514193-8 1994 IFN-gamma plus TNF or IL-1 beta increased endogenous tetrahydrobiopterin levels and GTP cyclohydrolase I activity, the rate-limiting enzyme of tetrahydrobiopterin synthesis. sapropterin 143-162 interferon gamma Homo sapiens 0-9 8182147-10 1994 Selective inhibition of IFN gamma-induced formation of 3HAA by DPI caused reversion of the inhibitory action of this cytokine on both PBMC- and MDM-mediated LDL oxidation. diphenyleneiodonium 63-66 interferon gamma Homo sapiens 24-33 7914437-0 1994 In vivo augmentation of IFN-gamma with a rIL-12 human/mouse chimera: pleiotropic effects against infectious agents in mice and rats. ril-12 41-47 interferon gamma Homo sapiens 24-33 8182147-2 1994 In this study we examined the potential inhibition by interferon-gamma (IFN gamma) of the early stages of low density lipoprotein (LDL) oxidation mediated by human peripheral blood mononuclear cells (PBMC) and monocyte-derived macrophages (MDM) in Ham"s F-10 medium supplemented with physiological amounts of L-tryptophan (Trp). Tryptophan 309-321 interferon gamma Homo sapiens 54-70 8182147-11 1994 These results show that IFN gamma treatment of human PBMC or MDM in vitro attenuates the extent of LDL oxidation caused by these cells, and indicate that Trp degradation with formation of 3HAA is a major contributing factor to this inhibitory activity. Tryptophan 154-157 interferon gamma Homo sapiens 24-33 8182147-2 1994 In this study we examined the potential inhibition by interferon-gamma (IFN gamma) of the early stages of low density lipoprotein (LDL) oxidation mediated by human peripheral blood mononuclear cells (PBMC) and monocyte-derived macrophages (MDM) in Ham"s F-10 medium supplemented with physiological amounts of L-tryptophan (Trp). Tryptophan 309-321 interferon gamma Homo sapiens 72-81 8182147-2 1994 In this study we examined the potential inhibition by interferon-gamma (IFN gamma) of the early stages of low density lipoprotein (LDL) oxidation mediated by human peripheral blood mononuclear cells (PBMC) and monocyte-derived macrophages (MDM) in Ham"s F-10 medium supplemented with physiological amounts of L-tryptophan (Trp). Tryptophan 323-326 interferon gamma Homo sapiens 54-70 8182147-2 1994 In this study we examined the potential inhibition by interferon-gamma (IFN gamma) of the early stages of low density lipoprotein (LDL) oxidation mediated by human peripheral blood mononuclear cells (PBMC) and monocyte-derived macrophages (MDM) in Ham"s F-10 medium supplemented with physiological amounts of L-tryptophan (Trp). Tryptophan 323-326 interferon gamma Homo sapiens 72-81 8182147-4 1994 Exposure of PBMC or MDM to IFN gamma induced the degradation of extracellular Trp with concomitant accumulation of kynurenine, anthranilic and 3-hydroxyanthranilic acid (3HAA) in the culture medium. PBMC 12-16 interferon gamma Homo sapiens 27-36 8182147-4 1994 Exposure of PBMC or MDM to IFN gamma induced the degradation of extracellular Trp with concomitant accumulation of kynurenine, anthranilic and 3-hydroxyanthranilic acid (3HAA) in the culture medium. Tryptophan 78-81 interferon gamma Homo sapiens 27-36 8182147-4 1994 Exposure of PBMC or MDM to IFN gamma induced the degradation of extracellular Trp with concomitant accumulation of kynurenine, anthranilic and 3-hydroxyanthranilic acid (3HAA) in the culture medium. Kynurenine 115-125 interferon gamma Homo sapiens 27-36 8182147-4 1994 Exposure of PBMC or MDM to IFN gamma induced the degradation of extracellular Trp with concomitant accumulation of kynurenine, anthranilic and 3-hydroxyanthranilic acid (3HAA) in the culture medium. anthranilic 127-138 interferon gamma Homo sapiens 27-36 8182147-4 1994 Exposure of PBMC or MDM to IFN gamma induced the degradation of extracellular Trp with concomitant accumulation of kynurenine, anthranilic and 3-hydroxyanthranilic acid (3HAA) in the culture medium. 3-Hydroxyanthranilic Acid 143-168 interferon gamma Homo sapiens 27-36 8182147-4 1994 Exposure of PBMC or MDM to IFN gamma induced the degradation of extracellular Trp with concomitant accumulation of kynurenine, anthranilic and 3-hydroxyanthranilic acid (3HAA) in the culture medium. 3-Hydroxyanthranilic Acid 170-174 interferon gamma Homo sapiens 27-36 8182147-7 1994 Incubation of LDL in Trp-supplemented F-10 medium resulted in a time-dependent oxidation of the lipoprotein that was accelerated in the presence of PBMC or MDM but inhibited strongly in the presence of both cells and IFN gamma, i.e., when Trp degradation and formation of 3HAA were induced. Tryptophan 21-24 interferon gamma Homo sapiens 217-226 8200605-1 1994 Increased interferon-gamma production with the dopaminergic agent lisuride]. Lisuride 66-74 interferon gamma Homo sapiens 10-26 8182147-7 1994 Incubation of LDL in Trp-supplemented F-10 medium resulted in a time-dependent oxidation of the lipoprotein that was accelerated in the presence of PBMC or MDM but inhibited strongly in the presence of both cells and IFN gamma, i.e., when Trp degradation and formation of 3HAA were induced. f-10 38-42 interferon gamma Homo sapiens 217-226 8182147-8 1994 In contrast, when IFN gamma was added to PBMC or MDM in F-10 medium that was virtually devoid of Trp, inhibition of cell-accelerated LDL oxidation was not observed. Tryptophan 97-100 interferon gamma Homo sapiens 18-27 8182147-10 1994 Selective inhibition of IFN gamma-induced formation of 3HAA by DPI caused reversion of the inhibitory action of this cytokine on both PBMC- and MDM-mediated LDL oxidation. 3-Hydroxyanthranilic Acid 55-59 interferon gamma Homo sapiens 24-33 8064732-5 1994 RESULTS: Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1, IL-6, TNF alpha and IFN-gamma, and no consistent effect on IL-4. Piroxicam 9-18 interferon gamma Homo sapiens 110-119 7743333-6 1994 Upon in vitro stimulation of TNF alpha (IFN gamma + muramyl dipeptide) normals" and immunocompetent patients" MO TNFR expression is decreased for the entire 18 h period during which secreted TNF alpha is produced, but immunoaberrant trauma patients" Mphi increased their TNFR expression, while concomitantly producing both secreted and cell-associated TNF alpha protein. Acetylmuramyl-Alanyl-Isoglutamine 52-69 interferon gamma Homo sapiens 40-49 8050458-2 1994 This may be due to increased biosynthesis of the potent vasodilator nitric oxide (NO) induced by cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), which are known to be generated during IL-2 therapy. Nitric Oxide 68-80 interferon gamma Homo sapiens 160-176 7918064-3 1994 BrdUrd uptake was inhibited by recombinant human IFN-gamma (100 U/ml) and by DEX (10(-6) M). Bromodeoxyuridine 0-6 interferon gamma Homo sapiens 49-58 8156998-0 1994 Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). Tyrosine 34-42 interferon gamma Homo sapiens 15-24 8156998-1 1994 Herein we report that interferon-gamma (IFN gamma) induces the rapid and reversible tyrosine phosphorylation of the IFN gamma receptor. Tyrosine 84-92 interferon gamma Homo sapiens 22-38 8156998-1 1994 Herein we report that interferon-gamma (IFN gamma) induces the rapid and reversible tyrosine phosphorylation of the IFN gamma receptor. Tyrosine 84-92 interferon gamma Homo sapiens 40-49 8156998-1 1994 Herein we report that interferon-gamma (IFN gamma) induces the rapid and reversible tyrosine phosphorylation of the IFN gamma receptor. Tyrosine 84-92 interferon gamma Homo sapiens 116-125 7913694-4 1994 Also, PBMC were more susceptible to lysis by TCL than K. Interferon-gamma (IFN-gamma) treatment of K resulted in increased MHC class I antigen expression and enhanced lytic susceptibility to TCL. Triclosan 45-48 interferon gamma Homo sapiens 57-73 7913694-4 1994 Also, PBMC were more susceptible to lysis by TCL than K. Interferon-gamma (IFN-gamma) treatment of K resulted in increased MHC class I antigen expression and enhanced lytic susceptibility to TCL. Triclosan 45-48 interferon gamma Homo sapiens 75-84 8039809-0 1994 Interferon-gamma enhances monocyte cytotoxicity via enhanced reactive oxygen intermediate production. reactive oxygen intermediate 61-89 interferon gamma Homo sapiens 0-16 8039809-3 1994 Treatment of monocytes with IFN-gamma (100 U/ml) caused a significant increase (P < 0.001) in lucigenin-dependent chemiluminescence and O2- production stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) during the first few days in culture but IFN-gamma was unable to prevent the decline to negligible levels of chemiluminescence and O2- production which occurred during the later days in vitro. 10,10'-dimethyl-9,9'-biacridinium 97-106 interferon gamma Homo sapiens 28-37 8039809-3 1994 Treatment of monocytes with IFN-gamma (100 U/ml) caused a significant increase (P < 0.001) in lucigenin-dependent chemiluminescence and O2- production stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) during the first few days in culture but IFN-gamma was unable to prevent the decline to negligible levels of chemiluminescence and O2- production which occurred during the later days in vitro. 10,10'-dimethyl-9,9'-biacridinium 97-106 interferon gamma Homo sapiens 262-271 8039809-3 1994 Treatment of monocytes with IFN-gamma (100 U/ml) caused a significant increase (P < 0.001) in lucigenin-dependent chemiluminescence and O2- production stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) during the first few days in culture but IFN-gamma was unable to prevent the decline to negligible levels of chemiluminescence and O2- production which occurred during the later days in vitro. Oxygen 139-141 interferon gamma Homo sapiens 28-37 8039809-3 1994 Treatment of monocytes with IFN-gamma (100 U/ml) caused a significant increase (P < 0.001) in lucigenin-dependent chemiluminescence and O2- production stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) during the first few days in culture but IFN-gamma was unable to prevent the decline to negligible levels of chemiluminescence and O2- production which occurred during the later days in vitro. N-Formylmethionine Leucyl-Phenylalanine 168-213 interferon gamma Homo sapiens 28-37 8039809-3 1994 Treatment of monocytes with IFN-gamma (100 U/ml) caused a significant increase (P < 0.001) in lucigenin-dependent chemiluminescence and O2- production stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) during the first few days in culture but IFN-gamma was unable to prevent the decline to negligible levels of chemiluminescence and O2- production which occurred during the later days in vitro. N-Formylmethionine Leucyl-Phenylalanine 168-213 interferon gamma Homo sapiens 262-271 8039809-3 1994 Treatment of monocytes with IFN-gamma (100 U/ml) caused a significant increase (P < 0.001) in lucigenin-dependent chemiluminescence and O2- production stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) during the first few days in culture but IFN-gamma was unable to prevent the decline to negligible levels of chemiluminescence and O2- production which occurred during the later days in vitro. Oxygen 352-354 interferon gamma Homo sapiens 28-37 8039809-5 1994 However, IFN-gamma decreased PMA-stimulated lucigenin-dependent chemiluminescence during the first 24 hr in vitro but then significantly enhanced (P < 0.001) chemiluminescence after 2-4 days in culture. 10,10'-dimethyl-9,9'-biacridinium 44-53 interferon gamma Homo sapiens 9-18 8039809-8 1994 It is concluded therefore, that IFN-gamma enhanced the cytotoxicity of freshly isolated human blood monocytes by increasing reactive oxygen intermediate generation but was unable to enhance the tumoricidal competence of macrophages as reactive nitrogen intermediate production was unaffected. reactive oxygen 124-139 interferon gamma Homo sapiens 32-41 7511593-0 1994 Interleukin-4 stimulates cGMP production by IFN-gamma-activated human monocytes. Cyclic GMP 25-29 interferon gamma Homo sapiens 44-53 7511593-5 1994 The accumulation of cGMP induced by IL-4 in IFN-gamma preincubated monocytes was dose-dependent and peaked about 15 min after its addition. Cyclic GMP 20-24 interferon gamma Homo sapiens 44-53 7511593-9 1994 In addition, IL-4 induced an increased secretion of nitrite by monocytes, that was potentiated by IFN-gamma and inhibited by L-NMMA. Nitrites 52-59 interferon gamma Homo sapiens 98-107 7511593-10 1994 Taken together, these results suggest that the sequential exposure of monocytes to IFN-gamma and IL-4 elicits the release of NO from L-arginine, which in turn is capable to stimulate soluble guanylyl cyclase. Arginine 133-143 interferon gamma Homo sapiens 83-92 8050458-2 1994 This may be due to increased biosynthesis of the potent vasodilator nitric oxide (NO) induced by cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), which are known to be generated during IL-2 therapy. Nitric Oxide 68-80 interferon gamma Homo sapiens 178-187 8050458-7 1994 The maximal induced NOx correlated with maximal TNF-alpha (r = 0.60, P < 0.04), IFN-gamma (r = 0.63, P < 0.02) and neopterin (r = 0.66, P < 0.01). nicotine 1-N-oxide 20-23 interferon gamma Homo sapiens 83-92 8195978-5 1994 The inhibitory effect of rhIL-1 beta or rhTNF-alpha on IFN-gamma-induced upregulation of HLA-DR expression was partially abated in the presence of indomethacin (reductions of 65.9% and 41.7%, respectively). Indomethacin 147-159 interferon gamma Homo sapiens 55-64 7510778-3 1994 The induction of neuroblastoma cell differentiation by TNF-alpha and IFN-gamma can be specifically inhibited by a nitric oxide (NO) synthase inhibitor, L-NG-monomethylarginine. Nitric Oxide 114-126 interferon gamma Homo sapiens 69-78 7510778-3 1994 The induction of neuroblastoma cell differentiation by TNF-alpha and IFN-gamma can be specifically inhibited by a nitric oxide (NO) synthase inhibitor, L-NG-monomethylarginine. omega-N-Methylarginine 152-175 interferon gamma Homo sapiens 69-78 7510778-6 1994 This is confirmed by the finding that the culture supernatants of N103 cells induced by TNF-alpha and IFN-gamma, but not that by IL-6, contained high levels of NO2-, the production of which was inhibited by L-NG-monomethylarginine. Nitrogen Dioxide 160-163 interferon gamma Homo sapiens 102-111 7510778-6 1994 This is confirmed by the finding that the culture supernatants of N103 cells induced by TNF-alpha and IFN-gamma, but not that by IL-6, contained high levels of NO2-, the production of which was inhibited by L-NG-monomethylarginine. omega-N-Methylarginine 207-230 interferon gamma Homo sapiens 102-111 8195978-7 1994 The addition of exogenous PGE2 inhibited the IFN-gamma-induced HLA-DR expression (P < 0.001). Dinoprostone 26-30 interferon gamma Homo sapiens 45-54 7513071-3 1994 We adopted in situ hybridization with radiolabeled complementary DNA oligonucleotide probes to enumerate mononuclear cells that expressed the T-helper type 1 (Th1) cell-related interferon-gamma (IFN-gamma) and Th2-associated interleukin-4 (IL-4) after short-term culture in the presence of autoantigen. Oligonucleotides 69-84 interferon gamma Homo sapiens 195-204 29539760-5 1994 The inhibitory effect of rhIL-1beta or rhTNF-alpha on IFN-gamma-induced upregulation of HLA-DR expression was partially abated in the presence of indomethacin (reductions of 65.9% and 41.7%, respectively). Indomethacin 146-158 interferon gamma Homo sapiens 54-63 29539760-7 1994 The addition of exogenous PGE2 inhibited the IFN-gamma-induced HLA-DR expression (P < 0.001). Dinoprostone 26-30 interferon gamma Homo sapiens 45-54 7999315-8 1994 In addition, interferon-gamma (IFN-gamma) stimulation of macrophages induces release of the glutamate-like agonist, quinolinate. Glutamic Acid 92-101 interferon gamma Homo sapiens 13-29 8084323-6 1994 These results support the view that interferon gamma may benefit these subjects by influencing oxygen-independent antimicrobial activity or other immunological parameters. Oxygen 95-101 interferon gamma Homo sapiens 36-52 7999315-8 1994 In addition, interferon-gamma (IFN-gamma) stimulation of macrophages induces release of the glutamate-like agonist, quinolinate. Glutamic Acid 92-101 interferon gamma Homo sapiens 31-40 7999315-8 1994 In addition, interferon-gamma (IFN-gamma) stimulation of macrophages induces release of the glutamate-like agonist, quinolinate. Quinolinic Acid 116-127 interferon gamma Homo sapiens 13-29 7999315-8 1994 In addition, interferon-gamma (IFN-gamma) stimulation of macrophages induces release of the glutamate-like agonist, quinolinate. Quinolinic Acid 116-127 interferon gamma Homo sapiens 31-40 7510216-1 1994 Stat91 (a 91 kd protein that acts as a signal transducer and activator of transcription) is inactive in the cytoplasm of untreated cells but is activated by phosphorylation on tyrosine in response to a number of polypeptide ligands, including interferon alpha (IFN-alpha) and IFN-gamma. Tyrosine 176-184 interferon gamma Homo sapiens 276-285 7515824-0 1994 Interferon-gamma modulates cAMP-induced mucin exocytosis without affecting mucin gene expression in a human colonic goblet cell line. Cyclic AMP 27-31 interferon gamma Homo sapiens 0-16 7515824-2 1994 The aim of the present study was (1) to investigate the regulatory effects of interferon-gamma on baseline and stimulated mucin secretion elicited by an increase in intracellular cAMP, either a short-term increase (induced by vasoactive intestinal peptide or by forskolin) or a long-term increase (cholera toxin-induced), and (2) to attempt to delineate the site of action of interferon-gamma. Cyclic AMP 179-183 interferon gamma Homo sapiens 78-94 7515824-5 1994 We demonstrated that, while interferon-gamma did not alter baseline Cl.16E mucin secretion and MUC2 gene expression, it strongly inhibited the protein kinase A-dependent secretory response to VIP, forskolin, or cholera toxin. Colforsin 197-206 interferon gamma Homo sapiens 28-44 7515824-7 1994 We thus concluded that the target for interferon-gamma inhibition of cAMP-stimulated Cl.16E mucin secretion is distal to protein kinase A and might be a component of the exocytotic machinery. Cyclic AMP 69-73 interferon gamma Homo sapiens 38-54 8118042-1 1994 Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-gamma (IFN gamma). 4,6-dinitro-o-cresol 37-43 interferon gamma Homo sapiens 172-188 8118042-1 1994 Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-gamma (IFN gamma). 4,6-dinitro-o-cresol 37-43 interferon gamma Homo sapiens 190-199 8118042-1 1994 Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-gamma (IFN gamma). Tryptophan 94-104 interferon gamma Homo sapiens 172-188 8118042-1 1994 Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-gamma (IFN gamma). Tryptophan 94-104 interferon gamma Homo sapiens 190-199 8118042-1 1994 Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-gamma (IFN gamma). Kynurenine 108-118 interferon gamma Homo sapiens 172-188 8118042-1 1994 Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-gamma (IFN gamma). Kynurenine 108-118 interferon gamma Homo sapiens 190-199 8011697-7 1994 Renewed interest has developed in hyperthermic limb perfusion for the treatment of transit and locally advanced recurrent disease because of the availability of melphalan and the recent reports of higher response rates with the addition of tumor necrosis factor and interferon gamma to melphalan. Melphalan 286-295 interferon gamma Homo sapiens 266-282 8313661-0 1994 Serum neopterin as a parameter for monitoring the course of renal cell carcinoma during interferon-gamma therapy. Neopterin 6-15 interferon gamma Homo sapiens 88-104 8313661-6 1994 In contrast to previous studies, the present report shows that although serum neopterin is an appropriate marker for IFN-gamma-induced reinforcement of monocyte/macrophage activity, it is not suitable for monitoring the course of metastatic renal cell carcinoma. Neopterin 78-87 interferon gamma Homo sapiens 117-126 8014029-1 1994 The fluoroquinolone antibiotic, ciprofloxacin (cipro), induces hyperproduction of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) in stimulated human peripheral blood lymphocytes. Fluoroquinolones 4-19 interferon gamma Homo sapiens 107-123 8014029-1 1994 The fluoroquinolone antibiotic, ciprofloxacin (cipro), induces hyperproduction of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) in stimulated human peripheral blood lymphocytes. Fluoroquinolones 4-19 interferon gamma Homo sapiens 125-134 8014029-1 1994 The fluoroquinolone antibiotic, ciprofloxacin (cipro), induces hyperproduction of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) in stimulated human peripheral blood lymphocytes. Ciprofloxacin 32-45 interferon gamma Homo sapiens 107-123 8014029-1 1994 The fluoroquinolone antibiotic, ciprofloxacin (cipro), induces hyperproduction of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) in stimulated human peripheral blood lymphocytes. Ciprofloxacin 32-45 interferon gamma Homo sapiens 125-134 8014029-1 1994 The fluoroquinolone antibiotic, ciprofloxacin (cipro), induces hyperproduction of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) in stimulated human peripheral blood lymphocytes. Ciprofloxacin 32-37 interferon gamma Homo sapiens 107-123 8014029-1 1994 The fluoroquinolone antibiotic, ciprofloxacin (cipro), induces hyperproduction of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) in stimulated human peripheral blood lymphocytes. Ciprofloxacin 32-37 interferon gamma Homo sapiens 125-134 8145547-9 1994 In addition, formalin fixation studies suggested that IFN-gamma may impair collagen cross-linking. Formaldehyde 13-21 interferon gamma Homo sapiens 54-63 8124835-9 1994 Vesnarinone inhibited the production of TNF-alpha and IFN-gamma both in healthy volunteers and in patients with heart failure. vesnarinone 0-11 interferon gamma Homo sapiens 54-63 7511192-0 1994 Rapid interferon-gamma-stimulated tyrosine phosphorylation of cytosolic and membranal proteins in HL-60 promyelocytic cells. Tyrosine 34-42 interferon gamma Homo sapiens 6-22 7511192-1 1994 The involvement of tyrosine phosphorylation in the early stages of interferon-gamma (IFN gamma)-induced monocytic differentiation of HL-60 cells was studied. Tyrosine 19-27 interferon gamma Homo sapiens 67-83 7511192-1 1994 The involvement of tyrosine phosphorylation in the early stages of interferon-gamma (IFN gamma)-induced monocytic differentiation of HL-60 cells was studied. Tyrosine 19-27 interferon gamma Homo sapiens 85-94 7511192-2 1994 Immunoblotting analysis demonstrated that IFN gamma induced rapid changes in the tyrosine phosphorylation of several endogenous cytosolic and membranal proteins. Tyrosine 81-89 interferon gamma Homo sapiens 42-51 8120139-9 1994 There were positive correlations between the numbers of IFN-gamma- and IL-2-secreting T cells and the numbers of B cells secreting antibodies against the acetylcholine receptor. Acetylcholine 154-167 interferon gamma Homo sapiens 56-65 8120139-10 1994 Our results show that acetylcholine receptor-stimulated T lymphocytes secrete IL-4, IFN-gamma and/or IL-2. Acetylcholine 22-35 interferon gamma Homo sapiens 84-93 7511192-4 1994 In membranes, the IFN gamma-induced phosphorylation of this protein was detectable in 5 min, remained elevated for 3 h and declined thereafter, while a gradual decrease in the phosphotyrosine content was observed in cytosols. Phosphotyrosine 176-191 interferon gamma Homo sapiens 18-27 7511192-7 1994 In contrast, 2-day exposure to IFN gamma was needed to potentiate significantly the tyrosine phosphorylation of a 36 kDa membranal polypeptide. Tyrosine 84-92 interferon gamma Homo sapiens 31-40 7511192-8 1994 These data support the involvement of tyrosine phosphorylation in the early stages of IFN gamma-induced monocytic differentiation of HL-60 cells. Tyrosine 38-46 interferon gamma Homo sapiens 86-95 7906904-0 1994 Inhibition of interferon-gamma-mediated immune functions by oligonucleotides. Oligonucleotides 60-76 interferon gamma Homo sapiens 14-30 7509445-3 1994 As was reported for fibroblasts, the IFN-gamma-regulated transcription factor GAF is phosphorylated at tyrosine after IFN-gamma treatment of HepG2 cells. Tyrosine 103-111 interferon gamma Homo sapiens 37-46 7509445-3 1994 As was reported for fibroblasts, the IFN-gamma-regulated transcription factor GAF is phosphorylated at tyrosine after IFN-gamma treatment of HepG2 cells. Tyrosine 103-111 interferon gamma Homo sapiens 118-127 7906904-4 1994 In our previous studies, a 26-mer oligonucleotide (T2) designed to form a triple helix with the X/X2 box promoter region of human MHC class II (DRA) gene was shown to prevent the induction by IFN-gamma of HLA-DR molecules. Oligonucleotides 34-49 interferon gamma Homo sapiens 192-201 7906904-5 1994 Here, we show that this oligonucleotide downregulates two other IFN gamma-inducible molecules, the adhesion molecule ICAM-1 and the Fc receptor for IgG on the surface of human cells. Oligonucleotides 24-39 interferon gamma Homo sapiens 64-73 7906904-7 1994 T2 oligonucleotide is shown to inhibit IFN gamma-mediated induction of Fc receptor on human blood monocytes as assessed by flow cytometry. t2 oligonucleotide 0-18 interferon gamma Homo sapiens 39-48 7906904-9 1994 The presented data suggest that oligonucleotide T2 blockade of IFN gamma-induction of different immune receptors on accessory cells is associated with inhibition of T cell proliferative responses. Oligonucleotides 32-47 interferon gamma Homo sapiens 63-72 7906905-1 1994 We report that certain oligonucleotides are capable of inhibiting cell surface induction of the major histocompatibility complex class I (MHC-I) proteins by interferon-gamma in K562 cells. Oligonucleotides 23-39 interferon gamma Homo sapiens 157-173 7906905-2 1994 The inhibition by oligodeoxy-nucleotide I 5" GGG GTT GGT TGT GTT GGG TGT TGT GT-RNH2 is dose-dependent, with an EC50 24 hr after dosing of approximately 4 microM for 800 U/ml interferon-gamma. Oligodeoxyribonucleotides 18-39 interferon gamma Homo sapiens 175-191 7906905-4 1994 Oligodeoxynucleotide I inhibits induction of MHC-I by interferon-gamma, but does not inhibit induction by either interferon-alpha or interferon-beta. oligodeoxynucleotide i 0-22 interferon gamma Homo sapiens 54-70 8120376-9 1994 Stimulation of IL2-activated NK cells with the mAb triggered TNF-alpha and IFN-gamma production, which was enhanced by using the mAb attached to plastic or in the presence of suboptimal concentrations of phorbol esters. Phorbol Esters 204-218 interferon gamma Homo sapiens 75-84 8120407-1 1994 This study analyzes the effects of the T cell cytokines IL-4 and IFN-gamma on the spontaneous and stimulated production of IL-8, MCP-1, IL-1 receptor antagonist (IL-1ra), and PGE by synoviocytes from rheumatoid arthritis (RA) and osteoarthritis (OA) patients. Prostaglandins E 175-178 interferon gamma Homo sapiens 65-74 7905278-0 1994 Interferon-gamma increases cellular calcium ion concentration and inositol 1,4,5-trisphosphate formation in human renal carcinoma cells: relation to ICAM-1 antigen expression. Calcium 36-43 interferon gamma Homo sapiens 0-16 8120407-8 1994 IL-4, on the other hand, markedly decreased the release of PGE, which was less susceptible to IFN-gamma. Prostaglandins E 59-62 interferon gamma Homo sapiens 94-103 8120407-9 1994 The observed effects on chemokines, IL-1ra expression, and PGE release by synoviocytes suggest that IFN-gamma and IL-4 are important regulatory elements in the inflamed synovium and may exert anti-inflammatory effects. Prostaglandins E 59-62 interferon gamma Homo sapiens 100-109 7905278-4 1994 IFN-gamma caused a fourfold increase in Ins 1,4,5-P3 formation. Inositol 1,4,5-Trisphosphate 40-52 interferon gamma Homo sapiens 0-9 7905278-0 1994 Interferon-gamma increases cellular calcium ion concentration and inositol 1,4,5-trisphosphate formation in human renal carcinoma cells: relation to ICAM-1 antigen expression. Inositol 1,4,5-Trisphosphate 66-94 interferon gamma Homo sapiens 0-16 7905278-8 1994 Our data suggest that IFN-gamma increases [Ca2+]i in CaKi-1 cells by stimulating influx of Ca2+ and release of Ca2+ from intracellular stores, probably via Ins 1,4,5-P3 formation. Inositol 1,4,5-Trisphosphate 156-168 interferon gamma Homo sapiens 22-31 7905278-9 1994 IFN-gamma signal transduction in our model may not be limited to an increase in [Ca2+]i and Ins 1,4,5-P3, since IFN-gamma-induced ICAM-1 antigen expression was abrogated to a minor degree by calcium antagonists and not coupled to Ins 1,4,5-P3 formation. Inositol 1,4,5-Trisphosphate 92-104 interferon gamma Homo sapiens 0-9 7905278-1 1994 In the present study, we investigated the effect of interferon-gamma (IFN-gamma) on cellular calcium ion concentration [Ca2+]i and inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) formation in the human renal carcinoma cell line CaKi-1. Calcium 93-100 interferon gamma Homo sapiens 52-68 7905278-9 1994 IFN-gamma signal transduction in our model may not be limited to an increase in [Ca2+]i and Ins 1,4,5-P3, since IFN-gamma-induced ICAM-1 antigen expression was abrogated to a minor degree by calcium antagonists and not coupled to Ins 1,4,5-P3 formation. Calcium 191-198 interferon gamma Homo sapiens 0-9 7905278-1 1994 In the present study, we investigated the effect of interferon-gamma (IFN-gamma) on cellular calcium ion concentration [Ca2+]i and inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) formation in the human renal carcinoma cell line CaKi-1. Calcium 93-100 interferon gamma Homo sapiens 70-79 7905278-9 1994 IFN-gamma signal transduction in our model may not be limited to an increase in [Ca2+]i and Ins 1,4,5-P3, since IFN-gamma-induced ICAM-1 antigen expression was abrogated to a minor degree by calcium antagonists and not coupled to Ins 1,4,5-P3 formation. Calcium 191-198 interferon gamma Homo sapiens 112-121 7905278-9 1994 IFN-gamma signal transduction in our model may not be limited to an increase in [Ca2+]i and Ins 1,4,5-P3, since IFN-gamma-induced ICAM-1 antigen expression was abrogated to a minor degree by calcium antagonists and not coupled to Ins 1,4,5-P3 formation. Inositol 1,4,5-Trisphosphate 230-242 interferon gamma Homo sapiens 0-9 7905278-1 1994 In the present study, we investigated the effect of interferon-gamma (IFN-gamma) on cellular calcium ion concentration [Ca2+]i and inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) formation in the human renal carcinoma cell line CaKi-1. Inositol 1,4,5-Trisphosphate 131-159 interferon gamma Homo sapiens 70-79 7905278-9 1994 IFN-gamma signal transduction in our model may not be limited to an increase in [Ca2+]i and Ins 1,4,5-P3, since IFN-gamma-induced ICAM-1 antigen expression was abrogated to a minor degree by calcium antagonists and not coupled to Ins 1,4,5-P3 formation. Inositol 1,4,5-Trisphosphate 230-242 interferon gamma Homo sapiens 112-121 7905278-3 1994 IFN-gamma caused a rapid concentration-dependent rise in [Ca2+]i, which was partly inhibited by diltiazem, a calcium channel blocker, TMB-8, an inhibitor of intracellular calcium redistribution, and in calcium-free medium. Diltiazem 96-105 interferon gamma Homo sapiens 0-9 7905278-3 1994 IFN-gamma caused a rapid concentration-dependent rise in [Ca2+]i, which was partly inhibited by diltiazem, a calcium channel blocker, TMB-8, an inhibitor of intracellular calcium redistribution, and in calcium-free medium. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 134-139 interferon gamma Homo sapiens 0-9 7905278-3 1994 IFN-gamma caused a rapid concentration-dependent rise in [Ca2+]i, which was partly inhibited by diltiazem, a calcium channel blocker, TMB-8, an inhibitor of intracellular calcium redistribution, and in calcium-free medium. Calcium 109-116 interferon gamma Homo sapiens 0-9 7905278-3 1994 IFN-gamma caused a rapid concentration-dependent rise in [Ca2+]i, which was partly inhibited by diltiazem, a calcium channel blocker, TMB-8, an inhibitor of intracellular calcium redistribution, and in calcium-free medium. Calcium 171-178 interferon gamma Homo sapiens 0-9 7513523-3 1994 Interferon-gamma primes neutrophils and macrophages for both O2- and nitric oxide synthesis. Superoxides 61-63 interferon gamma Homo sapiens 0-16 7513523-3 1994 Interferon-gamma primes neutrophils and macrophages for both O2- and nitric oxide synthesis. Nitric Oxide 69-81 interferon gamma Homo sapiens 0-16 8113833-0 1994 Phase I trial of interferon gamma to potentiate cyclosporine-induced graft-versus-host disease in women undergoing autologous bone marrow transplantation for breast cancer. Cyclosporine 48-60 interferon gamma Homo sapiens 17-33 8299680-3 1994 Sodium dodecylsulfate polyacrylamide gel electrophoresis (PAGE) and silver staining of purified N-IFN-gamma displayed three bands with an approximate molecular mass of 66, 62 and 54 kDa. Sodium Dodecyl Sulfate 0-21 interferon gamma Homo sapiens 98-107 8206875-4 1994 Interestingly, IFN-gamma dramatically stimulated the trypsin-like and chymotrypsin-like activities of the multifunctional proteasome and depressed the peptidylglutamyl-peptide-hydrolyzing activity, without affecting the activity for ATP-, ubiquitin-dependent proteolysis. Adenosine Triphosphate 233-236 interferon gamma Homo sapiens 15-24 8113394-3 1994 Treatment of the cells with IFN-gamma (300 U/ml) increased the release of [3H]arachidonic acid (AA) from prelabeled cells with a maximal effect at 12 h after stimulation. [3h]arachidonic acid 74-94 interferon gamma Homo sapiens 28-37 8113394-5 1994 Calcium ionophore A23187 (10(-5) M) further increased the [3H]AA release from the IFN-gamma-treated cells. Calcium 0-7 interferon gamma Homo sapiens 82-91 8113394-5 1994 Calcium ionophore A23187 (10(-5) M) further increased the [3H]AA release from the IFN-gamma-treated cells. Calcimycin 18-24 interferon gamma Homo sapiens 82-91 8113394-5 1994 Calcium ionophore A23187 (10(-5) M) further increased the [3H]AA release from the IFN-gamma-treated cells. Tritium 59-61 interferon gamma Homo sapiens 82-91 8113394-7 1994 Treatment with IFN-gamma also induced the release of 15-HETE, an arachidonic acid metabolite. Arachidonic Acid 65-81 interferon gamma Homo sapiens 15-24 8113833-1 1994 PURPOSE: We investigated if interferon gamma (IFN-gamma) could augment cyclosporine (CSA)-induced graft-versus-host disease (GVHD) following autologous bone marrow transplant in women with metastatic breast cancer and defined the toxicities of this therapy. Cyclosporine 71-83 interferon gamma Homo sapiens 28-55 8113833-1 1994 PURPOSE: We investigated if interferon gamma (IFN-gamma) could augment cyclosporine (CSA)-induced graft-versus-host disease (GVHD) following autologous bone marrow transplant in women with metastatic breast cancer and defined the toxicities of this therapy. Cyclosporine 85-88 interferon gamma Homo sapiens 28-55 8113833-11 1994 CONCLUSION: CSA-induced GVHD can be safely augmented by IFN-gamma in women treated with high-dose alkylating agents and autologous bone marrow transplantation. Cyclosporine 12-15 interferon gamma Homo sapiens 56-65 7905497-7 1994 In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells. Tetradecanoylphorbol Acetate 40-43 interferon gamma Homo sapiens 151-160 7905497-7 1994 In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells. Ionomycin 48-57 interferon gamma Homo sapiens 151-160 8027591-7 1994 Poly(I:C)-mediated reversal of IFN-gamma-resistant phenotype and induction of IDO and IRF1 messages are inhibited by 2-aminopurine. Poly I-C 0-9 interferon gamma Homo sapiens 31-40 8301141-9 1994 While crg-2 mRNA appeared within 2 h and reached a maximum in 6 to 8 h, Ia mRNA was not detected before 8 h. Cycloheximide superinduced crg-2 mRNA induced by IFN-gamma or UV-NDV but it abolished Ia mRNA induction by the same stimuli. Cycloheximide 109-122 interferon gamma Homo sapiens 158-167 8027591-7 1994 Poly(I:C)-mediated reversal of IFN-gamma-resistant phenotype and induction of IDO and IRF1 messages are inhibited by 2-aminopurine. 2-Aminopurine 117-130 interferon gamma Homo sapiens 31-40 8301213-1 1994 We investigated 12 antisense oligodeoxynucleotides, complementary to different regions of the human interferon-gamma (HuIFN-gamma) gene, for their ability to inhibit HuIFN-gamma production in cultures of single donor total leukocytes or lymphocytes (95% purity). Oligodeoxyribonucleotides 29-50 interferon gamma Homo sapiens 100-116 8186320-3 1994 In our experiments Zn2+ ions, added as ZnSO4, stimulated PBMC to produce IFN-gamma, IL-1 beta, IL-6, TNF-alpha, and sIL-2R in a concentration-dependent manner. Zinc 19-23 interferon gamma Homo sapiens 73-82 8307184-1 1994 We have previously shown that neopterin, 6-D-erythro-trihydroxypropyl-pteridine, synthesized by human monocytes/macrophages upon stimulation by interferon-gamma, enhances toxicity of reactive oxygen at neutral or slightly alkaline pH (7.5), but not at acidic pH (below 6.5). Neopterin 30-39 interferon gamma Homo sapiens 144-160 8307184-1 1994 We have previously shown that neopterin, 6-D-erythro-trihydroxypropyl-pteridine, synthesized by human monocytes/macrophages upon stimulation by interferon-gamma, enhances toxicity of reactive oxygen at neutral or slightly alkaline pH (7.5), but not at acidic pH (below 6.5). 6-d-erythro-trihydroxypropyl-pteridine 41-79 interferon gamma Homo sapiens 144-160 8186320-3 1994 In our experiments Zn2+ ions, added as ZnSO4, stimulated PBMC to produce IFN-gamma, IL-1 beta, IL-6, TNF-alpha, and sIL-2R in a concentration-dependent manner. Zinc Sulfate 39-44 interferon gamma Homo sapiens 73-82 7507317-1 1994 The present study demonstrates that human retinal pigmented epithelial cells produce nitric oxide (NO) upon co-treatment with interferon gamma (IFN gamma) and interleukin-1 beta (IL-1 beta). Nitric Oxide 85-97 interferon gamma Homo sapiens 126-142 7507317-1 1994 The present study demonstrates that human retinal pigmented epithelial cells produce nitric oxide (NO) upon co-treatment with interferon gamma (IFN gamma) and interleukin-1 beta (IL-1 beta). Nitric Oxide 85-97 interferon gamma Homo sapiens 144-153 8283033-7 1994 IFN-gamma R up-modulation also occurs on malignant T cells undergoing apoptosis after treatment with dexamethasone, on irradiated normal CD3+ PBL, and on cultured normal CD3+ thymocytes. Dexamethasone 101-114 interferon gamma Homo sapiens 0-9 8288893-1 1994 IFN-gamma induces the production of N-formyl-kynurenine from L-tryptophan in various cell types by the induction of the enzyme indoleamine 2,3-dioxygenase (IDO). N'-formylkynurenine 36-55 interferon gamma Homo sapiens 0-9 8288893-1 1994 IFN-gamma induces the production of N-formyl-kynurenine from L-tryptophan in various cell types by the induction of the enzyme indoleamine 2,3-dioxygenase (IDO). Tryptophan 61-73 interferon gamma Homo sapiens 0-9 8288893-4 1994 The determination of kynurenine in the supernatant of IFN-gamma activated cells was performed photometrically using a microplate reader. Kynurenine 21-31 interferon gamma Homo sapiens 54-63 7904998-5 1994 The action of IFN-gamma on the expression of squamous cell-specific genes is antagonized by retinoic acid and transforming growth factor beta 1. Tretinoin 92-105 interferon gamma Homo sapiens 14-23 8288893-5 1994 It was found that the amount of kynurenine produced was directly proportional to the amount of IFN-gamma used to activate cells. Kynurenine 32-42 interferon gamma Homo sapiens 95-104 8288893-7 1994 The induction of L-tryptophan degradation was specific for IFN-gamma since neither IFN-alpha, IFN-beta, IL-1, IL-2, IL-6, GM-CSF nor TNF alpha induced the production of detectable amounts of kynurenine by 86HG39 and 2D9 cells. Tryptophan 17-29 interferon gamma Homo sapiens 59-68 8288893-12 1994 We conclude that the measurement of kynurenine production induced by IFN-gamma can be used to determinate IFN-gamma content. Kynurenine 36-46 interferon gamma Homo sapiens 69-78 7908481-3 1994 Cy-A, known to inhibit IFN-gamma production in vitro, caused a rapid rise in serum IFN-gamma, but not Il-1 alpha and TNF alpha, levels in the patients and the IFN-gamma levels appeared to be inversely related to the therapeutic efficacy. Cyclosporine 0-4 interferon gamma Homo sapiens 23-32 8288893-12 1994 We conclude that the measurement of kynurenine production induced by IFN-gamma can be used to determinate IFN-gamma content. Kynurenine 36-46 interferon gamma Homo sapiens 106-115 7908481-0 1994 An unexpected increase in circulating IFN-gamma by cyclosporin A in atopic patients: a discrepancy between in vitro and in vivo events. Cyclosporine 51-64 interferon gamma Homo sapiens 38-47 7908481-3 1994 Cy-A, known to inhibit IFN-gamma production in vitro, caused a rapid rise in serum IFN-gamma, but not Il-1 alpha and TNF alpha, levels in the patients and the IFN-gamma levels appeared to be inversely related to the therapeutic efficacy. Cyclosporine 0-4 interferon gamma Homo sapiens 83-92 7908481-3 1994 Cy-A, known to inhibit IFN-gamma production in vitro, caused a rapid rise in serum IFN-gamma, but not Il-1 alpha and TNF alpha, levels in the patients and the IFN-gamma levels appeared to be inversely related to the therapeutic efficacy. Cyclosporine 0-4 interferon gamma Homo sapiens 83-92 7908481-4 1994 The observed increase in serum IFN-gamma levels during Cy-A therapy may have contributed to a marked clinical improvement of the AD. Cyclosporine 55-59 interferon gamma Homo sapiens 31-40 8250009-2 1994 IFN-gamma was not detected in normal peripheral blood plasma (PBP) or bone marrow plasma (BMP) and was present in PBP from only 2 of 22 patients and in BMP from 1 of 14 patients and the levels were low (< 1.5 U/ml). Monobenzone 62-65 interferon gamma Homo sapiens 0-9 7871951-11 1994 Since enhanced expression of interferon-gamma plays a crucial role in SAA as well as in MS and in IHT, similar pathogenetic principles may apply for these seemingly unrelated disorders. saa 70-73 interferon gamma Homo sapiens 29-45 7873053-11 1994 However, all clones secreted at least small amounts of IL2, IL4, IFN gamma and TNF alpha, if stimulated by PMA and ionomycin. Ionomycin 115-124 interferon gamma Homo sapiens 65-74 8155745-6 1994 The developed method was used to quantify the conversion of (13C6)L-tryptophan to (13C6)L-kynurenine by human monocytes (THP-1) stimulated with interferon-gamma, lung and brain tissue slices obtained from gerbils immune-stimulated with pokeweed mitogen. (13c6)l-tryptophan 60-78 interferon gamma Homo sapiens 144-160 7945175-7 1994 It was found that the T cell cytokine, interferon-gamma, inhibits cholesterol accumulation and foam cell formation by down-regulating the scavenger receptor on macrophages. Cholesterol 66-77 interferon gamma Homo sapiens 39-55 8155745-6 1994 The developed method was used to quantify the conversion of (13C6)L-tryptophan to (13C6)L-kynurenine by human monocytes (THP-1) stimulated with interferon-gamma, lung and brain tissue slices obtained from gerbils immune-stimulated with pokeweed mitogen. (13c6)l-kynurenine 82-100 interferon gamma Homo sapiens 144-160 8161653-0 1994 Monocyte activity in the presence of calcium phosphate activated by 1,25 (OH)2 VD3 and interferon-gamma. calcium phosphate 37-54 interferon gamma Homo sapiens 87-103 7865349-2 1994 In particular, the effect of interferon gamma on human mononuclear phagocyte iron metabolism and the role of iron availability of Legionella pneumophila intracellular multiplication in human monocytes has been elucidated. Iron 77-81 interferon gamma Homo sapiens 29-45 8161653-3 1994 A model study of the degradation of bioactive ceramics (calcium phosphate) using human peripheral blood monocytes activated by 1,25 (OH)2 VD3 and interferon (IFN)-gamma was implemented. calcium phosphate 56-73 interferon gamma Homo sapiens 146-168 8287610-8 1994 Although secretion of IFN-gamma after stimulation with phorbol myristate acetate (PMA)/Ca was significantly lower in children with atopic dermatitis compared with controls, the percentage of IFN-gamma-producing cells in the stimulated cultures from this group was equivalent to controls. Tetradecanoylphorbol Acetate 55-80 interferon gamma Homo sapiens 22-31 8287610-8 1994 Although secretion of IFN-gamma after stimulation with phorbol myristate acetate (PMA)/Ca was significantly lower in children with atopic dermatitis compared with controls, the percentage of IFN-gamma-producing cells in the stimulated cultures from this group was equivalent to controls. Tetradecanoylphorbol Acetate 82-85 interferon gamma Homo sapiens 22-31 8306959-0 1994 Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene. Tyrosine 0-8 interferon gamma Homo sapiens 120-129 8306959-5 1994 Tyrosine phosphorylation and DNA binding activity of p91 parallel transcription of ISGF2 in response to IFN alpha and/or IFN gamma, consistent with induction mediated by only a GAS. Tyrosine 0-8 interferon gamma Homo sapiens 121-130 8018412-0 1994 Modulation of cisplatin cytotoxicity by human recombinant interferon-gamma in human ovarian cancer cell lines. Cisplatin 14-23 interferon gamma Homo sapiens 58-74 7905817-3 1994 12-O-tetradecanoylphorbol 13-acetate (TPA) induced up-regulation of EGF receptor on MDA-MB-468 cells, and a marginal but significant increase was determined in BT-20 cells and in interferon gamma (IFN-gamma)-treated MDA-MB-468 cells. Tetradecanoylphorbol Acetate 0-36 interferon gamma Homo sapiens 179-206 7905817-3 1994 12-O-tetradecanoylphorbol 13-acetate (TPA) induced up-regulation of EGF receptor on MDA-MB-468 cells, and a marginal but significant increase was determined in BT-20 cells and in interferon gamma (IFN-gamma)-treated MDA-MB-468 cells. Tetradecanoylphorbol Acetate 38-41 interferon gamma Homo sapiens 179-206 8018412-4 1994 Synergy between these two drugs was observed in cell lines sensitive to IFN gamma, whatever their relative sensitivity or resistance to cisplatin, suggesting that IFN gamma enhances the cytotoxic activity of cisplatin. Cisplatin 208-217 interferon gamma Homo sapiens 72-81 8018412-4 1994 Synergy between these two drugs was observed in cell lines sensitive to IFN gamma, whatever their relative sensitivity or resistance to cisplatin, suggesting that IFN gamma enhances the cytotoxic activity of cisplatin. Cisplatin 208-217 interferon gamma Homo sapiens 163-172 8020552-6 1994 In addition, okadaic acid at doses > or = 20 nM induced LGL but not T cells to produce interferon-gamma. Okadaic Acid 13-25 interferon gamma Homo sapiens 90-106 7987085-3 1994 Comparing all-trans- with 9-cis-retinoic acid, the latter was more effective in inhibiting tumor cell growth and in inducing synergism with interferon-gamma. Alitretinoin 26-45 interferon gamma Homo sapiens 140-156 7987085-4 1994 Combination of retinoic acid with interferon-gamma increased the down-regulation of specific binding sites of interferon-gamma. Tretinoin 15-28 interferon gamma Homo sapiens 34-50 7987085-4 1994 Combination of retinoic acid with interferon-gamma increased the down-regulation of specific binding sites of interferon-gamma. Tretinoin 15-28 interferon gamma Homo sapiens 110-126 7982855-7 1994 Contrary to its enhancing effect on Fc gamma RII expression, dbcAMP suppressed the IFN-gamma-induced Fc gamma RIII expression on peripheral eosinophils. Bucladesine 61-67 interferon gamma Homo sapiens 83-92 7506700-2 1994 Interferon gamma, tumor necrosis factor-alpha, and interleukin-1 beta each markedly increased mRNA and protein levels of this enzyme in parallel with the production of nitrite, a stable oxidative metabolite of nitric oxide. Nitrites 168-175 interferon gamma Homo sapiens 0-45 7506700-2 1994 Interferon gamma, tumor necrosis factor-alpha, and interleukin-1 beta each markedly increased mRNA and protein levels of this enzyme in parallel with the production of nitrite, a stable oxidative metabolite of nitric oxide. Nitric Oxide 210-222 interferon gamma Homo sapiens 0-45 7506700-7 1994 These findings suggest that interferon gamma directly induces the expression of the inducible nitric oxide synthase gene, whereas tumor necrosis factor-alpha and interleukin-1 beta induce it, at least in part, via the induction of intermediary protein(s), and that transforming growth factor-beta 1 inhibits cytokine-induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase. nitric 94-100 interferon gamma Homo sapiens 28-44 7506700-7 1994 These findings suggest that interferon gamma directly induces the expression of the inducible nitric oxide synthase gene, whereas tumor necrosis factor-alpha and interleukin-1 beta induce it, at least in part, via the induction of intermediary protein(s), and that transforming growth factor-beta 1 inhibits cytokine-induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase. Nitric Oxide 94-106 interferon gamma Homo sapiens 28-44 7911045-7 1994 The data suggest that endogenous formation of interferon-gamma may be an important mediator of wasting in HIV infection, since this cytokine is responsible for the observed elevation of neopterin concentrations in body fluids. Neopterin 186-195 interferon gamma Homo sapiens 46-62 8154300-0 1994 Acridinium ester labelled cytokines: receptor binding studies with human interleukin-1 alpha, interleukin-1 beta and interferon-gamma. 9-Phenylcarboxylate-10-methylacridinium 0-16 interferon gamma Homo sapiens 117-133 7798293-6 1994 Synergistic growth inhibition resulted from the combined application of IFN gamma and DFMO in EFO-27 cell cultures. efo 94-97 interferon gamma Homo sapiens 72-81 7869186-3 1994 In the blood cell cultures of the untreated and sulfasalazine treated patients with Crohn"s disease and ulcerative colitis higher levels of TNF-alpha, IL-1-alpha and IL-1-beta were found whereas IL-2 production was decreased and IFN-gamma-production was not significantly different as compared to the controls. Sulfasalazine 48-61 interferon gamma Homo sapiens 229-238 8110731-1 1994 Circulating neopterin is derived from monocytes and/or macrophages that produce it upon stimulation by interferon-gamma released from activated T cells. Neopterin 12-21 interferon gamma Homo sapiens 103-119 7507500-3 1994 We describe the use of in situ hybridization with complementary DNA oligonucleotide probes to detect and enumerate mononuclear cells expressing mRNA for the cytokines interferon-gamma (IFN-gamma) which augments cell-mediated immunity; interleukin-4 (IL-4) which promotes the B cell response; and transforming growth factor beta (TGF-beta) that in many cases downregulates immune responses. Oligonucleotides 68-83 interferon gamma Homo sapiens 167-183 7507500-3 1994 We describe the use of in situ hybridization with complementary DNA oligonucleotide probes to detect and enumerate mononuclear cells expressing mRNA for the cytokines interferon-gamma (IFN-gamma) which augments cell-mediated immunity; interleukin-4 (IL-4) which promotes the B cell response; and transforming growth factor beta (TGF-beta) that in many cases downregulates immune responses. Oligonucleotides 68-83 interferon gamma Homo sapiens 185-194 7526029-2 1994 Primary cultured thyroid cells were incubated for three days with IFN gamma (10 to 800 U/ml) or PHA (1 to 50 micrograms/ml) in the presence of FK506. Tacrolimus 143-148 interferon gamma Homo sapiens 66-75 8255163-3 1994 In this study, we showed vesnarinone had inhibitory effects on the production of tumor necrosis factor-alpha, interferon-gamma, interleukin-1 beta and interleukin-2 by stimulated human peripheral blood mononuclear cells, human Jurkat T cell line and THP-1 monocytic cell line. vesnarinone 25-36 interferon gamma Homo sapiens 110-126 18475607-3 1994 The addition to BEC cultures of different concentrations of PHA-stimulated BMC-CM, or of IFN-gamma induced a dosedependent increase of HIA-DR and ICAM-1 expression, while no effect was observed with unstimulated BMC-CM. S-benzyl-N-malonylcysteine 212-215 interferon gamma Homo sapiens 89-98 8132219-4 1994 Of the various cytokines tested, interleukin-4 (IL-4) reduced the NES-induced inhibition of Ig production, whereas other cytokines, including IL-1 beta, IL-2, IL-3, IL-5, IL-6, interferon-alpha (IFN-alpha), IFN-gamma, granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Epo) failed to do so. Nedocromil 66-69 interferon gamma Homo sapiens 207-216 7904773-4 1994 Because interferon-gamma (IFN-gamma) is a potent M phi activation molecule which regulates both M phi PGE2 and class-II expression, the effects of IFN-gamma on tumour-induced suppression of autoreactive T-cell proliferation were investigated. Dinoprostone 102-106 interferon gamma Homo sapiens 8-24 8142896-0 1994 Structural analysis and localization of the carbohydrate moieties of a soluble human interferon gamma receptor produced in baculovirus-infected insect cells. Carbohydrates 44-56 interferon gamma Homo sapiens 85-101 7904773-4 1994 Because interferon-gamma (IFN-gamma) is a potent M phi activation molecule which regulates both M phi PGE2 and class-II expression, the effects of IFN-gamma on tumour-induced suppression of autoreactive T-cell proliferation were investigated. Dinoprostone 102-106 interferon gamma Homo sapiens 26-35 8290891-0 1994 Interferon-gamma stimulates neopterin release from cultured kidney epithelial cells. Neopterin 28-37 interferon gamma Homo sapiens 0-16 7904773-6 1994 Antibody (Ab) neutralization of endogenous IFN-gamma activity reduced TBH M phi-mediated suppression. tbh 70-73 interferon gamma Homo sapiens 43-52 7904773-8 1994 Indomethacin treatment blocked IFN-gamma-induced suppression in TBH M phi-T cell cultures. Indomethacin 0-12 interferon gamma Homo sapiens 31-40 8290891-2 1994 In this study interferon gamma (IFN-gamma) was shown to induce neopterin release from KEC in a dose- and time-dependent manner. Neopterin 63-72 interferon gamma Homo sapiens 14-41 8290891-4 1994 By itself TNF-alpha induced a release of small amounts of neopterin but strongly potentiated the effect of IFN-gamma in a synergistic manner to induce neopterin secretion. Neopterin 151-160 interferon gamma Homo sapiens 107-116 7904773-10 1994 Exogenous IFN-gamma increased early PGE2 production in TBH M phi cultures but decreased production in NH M phi cultures. Dinoprostone 36-40 interferon gamma Homo sapiens 10-19 8310519-7 1994 In parallel, a greater amount of IL-2 and IFN-gamma mRNA was observed in lymphocytes incubated with both cipro and CsA as compared with CsA alone. Ciprofloxacin 105-110 interferon gamma Homo sapiens 42-51 8310519-1 1994 The fluoroquinolone antibiotic ciprofloxacin (cipro) has been reported to upregulate interleukin 2 and interferon-gamma production in lectin-stimulated lymphocytes. Fluoroquinolones 4-19 interferon gamma Homo sapiens 103-119 8310519-7 1994 In parallel, a greater amount of IL-2 and IFN-gamma mRNA was observed in lymphocytes incubated with both cipro and CsA as compared with CsA alone. Cyclosporine 115-118 interferon gamma Homo sapiens 42-51 8310519-1 1994 The fluoroquinolone antibiotic ciprofloxacin (cipro) has been reported to upregulate interleukin 2 and interferon-gamma production in lectin-stimulated lymphocytes. Ciprofloxacin 31-44 interferon gamma Homo sapiens 103-119 8310519-1 1994 The fluoroquinolone antibiotic ciprofloxacin (cipro) has been reported to upregulate interleukin 2 and interferon-gamma production in lectin-stimulated lymphocytes. Ciprofloxacin 31-36 interferon gamma Homo sapiens 103-119 8310519-7 1994 In parallel, a greater amount of IL-2 and IFN-gamma mRNA was observed in lymphocytes incubated with both cipro and CsA as compared with CsA alone. Cyclosporine 136-139 interferon gamma Homo sapiens 42-51 8310519-5 1994 The present study also shows that cipro supplemented with CsA and PHA resulted in significant higher concentrations of IL-2 (up to 60 times) and IFN-gamma (4.3 times) as compared with PHA and CsA alone. Ciprofloxacin 34-39 interferon gamma Homo sapiens 145-154 8310519-8 1994 Our results reveal that CsA-dependent inhibition of both IL-2 and IFN-gamma expression is counteracted by high concentrations of cipro. Cyclosporine 24-27 interferon gamma Homo sapiens 66-75 8310519-5 1994 The present study also shows that cipro supplemented with CsA and PHA resulted in significant higher concentrations of IL-2 (up to 60 times) and IFN-gamma (4.3 times) as compared with PHA and CsA alone. Cyclosporine 58-61 interferon gamma Homo sapiens 145-154 8310519-8 1994 Our results reveal that CsA-dependent inhibition of both IL-2 and IFN-gamma expression is counteracted by high concentrations of cipro. Ciprofloxacin 129-134 interferon gamma Homo sapiens 66-75 8629278-6 1994 It was further demonstrated that these lymphokines, especially IFN-gamma, induced the expression of mRNA for the inducible type of nitric oxide (NO) synthase in thymic stromal cells and that enhanced levels of NO were produced by stromal cells cultures with T cells plus antigen or stimulated with rIFN-gamma or rTNF-alpha. Nitric Oxide 131-143 interferon gamma Homo sapiens 63-72 8171746-3 1993 Various cellular effects with the addition of thymidine to the medium with methotrexate and IFN-gamma were studied. Thymidine 46-55 interferon gamma Homo sapiens 92-101 7974918-4 1994 The calcium ionophore, 4-bromo-calcium ionophore A23187 (Bromo-A23187) significantly enhanced the IFN-gamma and PMA effect. Calcium 4-11 interferon gamma Homo sapiens 98-107 7974918-4 1994 The calcium ionophore, 4-bromo-calcium ionophore A23187 (Bromo-A23187) significantly enhanced the IFN-gamma and PMA effect. 4-bromo-calcium 23-38 interferon gamma Homo sapiens 98-107 7974918-4 1994 The calcium ionophore, 4-bromo-calcium ionophore A23187 (Bromo-A23187) significantly enhanced the IFN-gamma and PMA effect. Calcimycin 49-55 interferon gamma Homo sapiens 98-107 7974918-4 1994 The calcium ionophore, 4-bromo-calcium ionophore A23187 (Bromo-A23187) significantly enhanced the IFN-gamma and PMA effect. bromo-a23187 57-69 interferon gamma Homo sapiens 98-107 8171746-5 1993 The reduction of cellular folate by methotrexate was also enhanced in combination with IFN-gamma. Folic Acid 26-32 interferon gamma Homo sapiens 87-96 8290364-7 1993 A region that carries X and CRS permits both lymphoid activity and IFN-gamma response. Chromium 28-31 interferon gamma Homo sapiens 67-76 8171746-6 1993 Cell cycle delay, resulting in cell growth inhibition of folate depletion, caused the induction of differentiation in U-937 cells, which was found to be greater with methotrexate + IFN-gamma than with methotrexate alone. Folic Acid 57-63 interferon gamma Homo sapiens 181-190 8290364-10 1993 In vivo competition studies show that titratable trans-acting factors, shared by Class I and Class II promoters, mediate the CRS-dependent IFN-gamma response. Chromium 125-128 interferon gamma Homo sapiens 139-148 8290364-13 1993 Three other CRS complexes that are upregulated by either IFN-alpha and IFN-gamma are competed by a non-Class II, IFN-alpha stimulated response element (ISRE), providing evidence for the functional interconnection of these cytokines. Chromium 12-15 interferon gamma Homo sapiens 71-80 8171746-9 1993 The addition of thymidine to the medium also caused reversal of the inhibitory effect of methotrexate and IFN-gamma on cell growth and repletion of the endogenous folate level. Thymidine 16-25 interferon gamma Homo sapiens 106-115 8171746-9 1993 The addition of thymidine to the medium also caused reversal of the inhibitory effect of methotrexate and IFN-gamma on cell growth and repletion of the endogenous folate level. Folic Acid 163-169 interferon gamma Homo sapiens 106-115 8243565-3 1993 A rapid decrease in cell viability of U937 cells (MTT assay) could be observed at an effector-to-target cell (E:T) ratio of 10 in the presence of interferon (IFN)-gamma-activated monocytes. monooxyethylene trimethylolpropane tristearate 50-53 interferon gamma Homo sapiens 146-168 7504784-1 1993 Binding of interferons IFN-alpha and IFN-gamma to their cell surface receptors promptly induces tyrosine phosphorylation of latent cytoplasmic transcriptional activators (or Stat proteins, for signal transducers and activators of transcription). Tyrosine 96-104 interferon gamma Homo sapiens 37-46 7504785-1 1993 Interferons IFN-alpha/beta and IFN-gamma act through independent cell-surface receptors, inducing gene expression through tyrosine phosphorylation of cytoplasmic transcription factors . Tyrosine 122-130 interferon gamma Homo sapiens 31-40 7509103-1 1993 We investigated the effects of FK506, a novel immunosuppressive agent, on the phytohemagglutinin (PHA) or interferon-gamma (IFN-gamma)-induced expression of HLA-DR antigen, accessory cell function and proliferation of primary cultured human thyroid cells. Tacrolimus 31-36 interferon gamma Homo sapiens 106-133 7902828-7 1993 However, treatment with cycloheximide, after stimulation with IFN-gamma, resulted in increased levels of membrane associated ICAM-1. Cycloheximide 24-37 interferon gamma Homo sapiens 62-71 8252811-4 1993 The present study analyses (i) the capacity of Q-Vax to induce T cell sensitization which leads to IFN-gamma responses on antigen stimulation, and (ii) the immunomodulatory, (down-regulatory) effects of the Phase I lipopolysaccharide (LPS) of the organism, which interacts with monocyte/macrophages to limit IL-2 production and production of IFN-gamma by sensitized T lymphocytes. q-vax 47-52 interferon gamma Homo sapiens 99-108 7905486-6 1993 In contrast, later activation events including the expression of the surface activation markers CD25, CD45RO, and CD71 as well as the production of IFN-gamma were found to require exogenous glutamine supply. Glutamine 190-199 interferon gamma Homo sapiens 148-157 8151136-2 1993 We tested the hypothesis that suppression of endothelial cell proliferation by IFN-gamma is mediated by an increase in xanthine oxidase-derived O2-.. Human umbilical vein endothelial cells (HUVEC) were exposed to recombinant human IFN-gamma. Oxygen 144-146 interferon gamma Homo sapiens 79-88 8151136-3 1993 We found that [3H]thymidine uptake decreased (p < 0.05) with increasing doses of IFN-gamma. Tritium 15-17 interferon gamma Homo sapiens 84-93 8151136-3 1993 We found that [3H]thymidine uptake decreased (p < 0.05) with increasing doses of IFN-gamma. Thymidine 18-27 interferon gamma Homo sapiens 84-93 8138825-7 1993 In CSF of RRMS patients neopterin and L-TRP correlated negatively, reflecting the interferon-gamma mediated activation of macrophages in acute relapse. Neopterin 24-33 interferon gamma Homo sapiens 82-98 8274426-6 1993 Comparing all-trans- with 9-cis-RA, the latter was more effective in inhibiting tumor cell growth and in inducing synergism with interferon-gamma. Tretinoin 26-34 interferon gamma Homo sapiens 129-145 7693710-2 1993 In cultured vascular smooth muscle cells, interferon gamma (IFN-gamma) induced the accumulation of nitrite, a stable metabolite of nitric oxide, in a dose- and time-dependent manner. Nitrites 99-106 interferon gamma Homo sapiens 42-69 8278994-1 1993 Perioperative donor spleen cells plus cyclosporine suppress IL-2 and interferon-gamma production. Cyclosporine 38-50 interferon gamma Homo sapiens 69-85 8278994-8 1993 Analysis of sections of recipients" spleens showed that spleen cell/CsA therapy led to significant reductions versus untreated controls, in expression of IL-2, IFN-gamma, and IL-2R. Cyclosporine 68-71 interferon gamma Homo sapiens 160-169 7693710-2 1993 In cultured vascular smooth muscle cells, interferon gamma (IFN-gamma) induced the accumulation of nitrite, a stable metabolite of nitric oxide, in a dose- and time-dependent manner. Nitric Oxide 131-143 interferon gamma Homo sapiens 42-69 7693710-4 1993 Forskolin, a direct activator of adenylate cyclase, or dibutyryl cAMP alone caused small increases in nitrite accumulation and iNOS mRNA and protein levels and synergistically enhanced the IFN-gamma-stimulated reactions. Colforsin 0-9 interferon gamma Homo sapiens 189-198 7693710-4 1993 Forskolin, a direct activator of adenylate cyclase, or dibutyryl cAMP alone caused small increases in nitrite accumulation and iNOS mRNA and protein levels and synergistically enhanced the IFN-gamma-stimulated reactions. Cyclic AMP 65-69 interferon gamma Homo sapiens 189-198 7693710-6 1993 Prostaglandin E1 and beraprost, a stable analogue of prostaglandin I2, which by themselves showed only marginal effects on these reactions, also synergized with IFN-gamma to stimulate the reactions. Alprostadil 0-16 interferon gamma Homo sapiens 161-170 7693710-6 1993 Prostaglandin E1 and beraprost, a stable analogue of prostaglandin I2, which by themselves showed only marginal effects on these reactions, also synergized with IFN-gamma to stimulate the reactions. beraprost 21-30 interferon gamma Homo sapiens 161-170 7693710-6 1993 Prostaglandin E1 and beraprost, a stable analogue of prostaglandin I2, which by themselves showed only marginal effects on these reactions, also synergized with IFN-gamma to stimulate the reactions. Epoprostenol 53-69 interferon gamma Homo sapiens 161-170 8250840-1 1993 We have investigated the effects of the pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) on the iron metabolism of the human monocytic cell line U937. Iron 180-184 interferon gamma Homo sapiens 144-160 8250840-1 1993 We have investigated the effects of the pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) on the iron metabolism of the human monocytic cell line U937. Iron 180-184 interferon gamma Homo sapiens 162-171 8250840-4 1993 IL-1 beta, TNF alpha and IFN gamma all decreased transferrin-iron uptake into cells, and all three cytokines had effects on the proportion of iron associated with ferritin. Iron 61-65 interferon gamma Homo sapiens 25-34 8244579-12 1993 To strengthen these findings we evaluated the half-lives of the mRNA after IFN-gamma induction by means of actinomycin D treatment. Dactinomycin 107-120 interferon gamma Homo sapiens 75-84 8215435-3 1993 Amino acid sequence analysis of a recombinant human interferon-gamma stored for 2 years showed a major sequence starting with the intact N-terminal methionine and a minor sequence corresponding to the C-terminal seven amino acids of the intact protein. Methionine 148-158 interferon gamma Homo sapiens 52-68 7901766-6 1993 Unlike IFNs alpha and beta, IFN-gamma induces rapid tyrosine phosphorylation of JAK2 in wild-type cells, and JAK2 immunoprecipitates from these cells show tyrosine kinase activity. Tyrosine 52-60 interferon gamma Homo sapiens 28-37 7507316-6 1993 For instance, CsA and FK 506 inhibit the transcription of IL-3, IL-4, IFN gamma, TNF alpha or GM-CSF by activated T cells, and rapamycin has been shown to block the response to various growth factors such as IL-3, IL-4 or IL-6. Cyclosporine 14-17 interferon gamma Homo sapiens 70-79 7507316-6 1993 For instance, CsA and FK 506 inhibit the transcription of IL-3, IL-4, IFN gamma, TNF alpha or GM-CSF by activated T cells, and rapamycin has been shown to block the response to various growth factors such as IL-3, IL-4 or IL-6. Tacrolimus 22-28 interferon gamma Homo sapiens 70-79 8215435-12 1993 The conclusion is recombinant methionyl human interferon-gamma undergoes a specific cleavage at the C-terminal side of residue 137 phenylalanine, and a conventional peptide bond was formed between residues 137 and 1 methionine. Phenylalanine 131-144 interferon gamma Homo sapiens 46-62 8215435-12 1993 The conclusion is recombinant methionyl human interferon-gamma undergoes a specific cleavage at the C-terminal side of residue 137 phenylalanine, and a conventional peptide bond was formed between residues 137 and 1 methionine. Methionine 216-226 interferon gamma Homo sapiens 46-62 8223868-6 1993 Plasma membranes from T cells activated by immobilized anti-CD3 were able to effectively induce RNI production in IFN-gamma-primed macrophages. rni 96-99 interferon gamma Homo sapiens 114-123 7509306-7 1993 Furthermore, upon stimulation with concanavalin A (Con A), phytohaemaggultinin or immobilized anti-CD3 antibodies, gp90MEL-14 negative CD8+T cells showed significantly higher proliferative responses and generated extremely higher amounts of IL-2 and IFN-gamma than gp90MEL-14 positive CD8+ T cells did. phytohaemaggultinin 59-78 interferon gamma Homo sapiens 250-259 8228802-5 1993 These IFN-gamma promoter constructs faithfully mirrored expression of the endogenous gene, in that expression required activation both with ionomycin and PMA, was inhibited by cyclosporin A, and was not observed in U937 or THP-1 cells. Tetradecanoylphorbol Acetate 154-157 interferon gamma Homo sapiens 6-15 8228802-5 1993 These IFN-gamma promoter constructs faithfully mirrored expression of the endogenous gene, in that expression required activation both with ionomycin and PMA, was inhibited by cyclosporin A, and was not observed in U937 or THP-1 cells. Ionomycin 140-149 interferon gamma Homo sapiens 6-15 8228802-5 1993 These IFN-gamma promoter constructs faithfully mirrored expression of the endogenous gene, in that expression required activation both with ionomycin and PMA, was inhibited by cyclosporin A, and was not observed in U937 or THP-1 cells. Cyclosporine 176-189 interferon gamma Homo sapiens 6-15 8227314-3 1993 Adhesion of resting lymphocytes increased significantly following endothelial treatment with interferon-gamma (IFN-gamma; 11.7 +/- 1.0%), interleukin-1 (IL-1; 14.9 +/- 1.2%), astrocyte conditioned medium (ACM; 12.7 +/- 0.9%) or forskolin (13.9 +/- 1.2%). Colforsin 228-237 interferon gamma Homo sapiens 93-109 7903279-4 1993 Nicotinamide and 3-AB dose-dependently inhibited the induction of ICAM-1 expression by IFN-gamma or PHA on thyroid cells. Niacinamide 0-12 interferon gamma Homo sapiens 87-96 8294138-0 1993 Activation of human monocyte/macrophage cytotoxicity by IL-2/IFN gamma is linked to increased expression of an antitumor receptor with specificity for acetylated mannose. Mannose 162-169 interferon gamma Homo sapiens 61-70 7903279-4 1993 Nicotinamide and 3-AB dose-dependently inhibited the induction of ICAM-1 expression by IFN-gamma or PHA on thyroid cells. 3-aminobenzamide 17-21 interferon gamma Homo sapiens 87-96 8408457-1 1993 To evaluate the role of interferon-gamma (IFN gamma) on human thyroid-specific gene expression, the effect of IFN gamma on TSH- and cAMP-induced TSH receptor gene expression was studied using cultured thyroid cells obtained from normal thyroid glands and those from patients with Graves" disease. Cyclic AMP 132-136 interferon gamma Homo sapiens 110-119 8023698-3 1993 FCS was also found to be a dose-dependent enhancer of the IFN-gamma-induced 2",5"-oligoadenylate (2-5A) synthetase production. 2',5'-oligoadenylate 76-96 interferon gamma Homo sapiens 58-67 8408457-1 1993 To evaluate the role of interferon-gamma (IFN gamma) on human thyroid-specific gene expression, the effect of IFN gamma on TSH- and cAMP-induced TSH receptor gene expression was studied using cultured thyroid cells obtained from normal thyroid glands and those from patients with Graves" disease. Thyrotropin 123-126 interferon gamma Homo sapiens 110-119 8408457-7 1993 These results indicate that IFN gamma suppresses TSH- and cAMP stimulated human TSH receptor gene expression, resulting in a decrease in the number of TSH receptors. Cyclic AMP 58-62 interferon gamma Homo sapiens 28-37 8376801-3 1993 In 20 individuals with lymphatic filariasis, frequency analysis of PBMC secreting IL-4 and IFN-gamma indicated that the F0 of PAg-specific IL-4-secreting cells (geometric mean F0 (GM): 1/12,100) was 57-fold higher than the corresponding F0 of NPAg-reactive cells (GM: 1/692,000; p < 0.02). phenylacetylglycine 126-129 interferon gamma Homo sapiens 91-100 8376801-4 1993 In marked contrast, the F0 of IFN-gamma-secreting cells responding to PAg (GM: 1/2,700) did not differ from those of cells specific for NAPg (GM: 1/3,400; p = 0.83). phenylacetylglycine 70-73 interferon gamma Homo sapiens 30-39 8376801-7 1993 Again, the corresponding proportions of Ag-specific IFN-gamma-and GM-CSF-secreting CD4+ cells were equivalent for PAg and NPAg. phenylacetylglycine 114-117 interferon gamma Homo sapiens 52-61 8260535-6 1993 When human monocytes were preincubated for 1 h with IFN-gamma (100 U/ml) prior to the addition of dexamethasone (10(-6) M) and prior to the stimulation with LPS, the dexamethasone-mediated inhibition of IL-1 beta mRNA and IL-1 beta protein synthesis was totally neutralized by IFN-gamma. Dexamethasone 166-179 interferon gamma Homo sapiens 52-61 8258946-4 1993 IFN-gamma-treated TEC supernatant does not diminish KI T cell proliferation and IFN-gamma-treated TEC fixed with glutaraldehyde remain less capable of inducing KI T cell proliferation. Turpentine 18-21 interferon gamma Homo sapiens 0-9 8258946-4 1993 IFN-gamma-treated TEC supernatant does not diminish KI T cell proliferation and IFN-gamma-treated TEC fixed with glutaraldehyde remain less capable of inducing KI T cell proliferation. Glutaral 113-127 interferon gamma Homo sapiens 80-89 8260535-6 1993 When human monocytes were preincubated for 1 h with IFN-gamma (100 U/ml) prior to the addition of dexamethasone (10(-6) M) and prior to the stimulation with LPS, the dexamethasone-mediated inhibition of IL-1 beta mRNA and IL-1 beta protein synthesis was totally neutralized by IFN-gamma. Dexamethasone 166-179 interferon gamma Homo sapiens 277-286 8260535-8 1993 A preincubation period of at least 1 h with IFN-gamma was necessary for the neutralization of the dexamethasone effect. Dexamethasone 98-111 interferon gamma Homo sapiens 44-53 8260535-9 1993 If IFN-gamma was given at the same time or after dexamethasone, only a weak effect was found. Dexamethasone 49-62 interferon gamma Homo sapiens 3-12 8309724-5 1993 This article illustrates the difficulty of treatment of visceral leishmaniasis by reporting the case of an immunocompetent 36-year-old patient whose bone marrow cultures remained positive after successive treatment, over 48 months, with two courses of Glucantime (60 mg/kg/day for 15 days), one course of allopurinol (10 mg/kg/4 weeks), two courses of Glucantime in combination with interferon gamma, splenectomy, and one course of Pentostam (20 mg/kg/4 weeks). Meglumine Antimoniate 252-262 interferon gamma Homo sapiens 383-399 8292227-4 1993 However, when given exogenously, IFN-gamma delayed the onset and reduced the incidence of Cas-induced neurologic disease. Calcium 90-93 interferon gamma Homo sapiens 33-42 8397445-3 1993 Epidermal growth factor, interferon-gamma, and interleukin-6 all activated, through direct tyrosine phosphorylation, latent cytoplasmic transcription factors that recognized similar DNA elements. Tyrosine 91-99 interferon gamma Homo sapiens 25-41 7690989-0 1993 A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Phosphotyrosine 9-24 interferon gamma Homo sapiens 75-91 7690989-1 1993 Interferon-gamma (IFN-gamma) stimulates transcription of specific genes by inducing tyrosine phosphorylation of a 91-kilodalton cytoplasmic protein (termed STAT for signal transducer and activator of transcription). Tyrosine 84-92 interferon gamma Homo sapiens 0-16 7690989-1 1993 Interferon-gamma (IFN-gamma) stimulates transcription of specific genes by inducing tyrosine phosphorylation of a 91-kilodalton cytoplasmic protein (termed STAT for signal transducer and activator of transcription). Tyrosine 84-92 interferon gamma Homo sapiens 18-27 8397256-1 1993 The monocyte-derived inflammatory mediator, prostaglandin E2 (PGE2), can reduce IFN-gamma production, and this in turn may relate to IL-4 up-regulation of IgE synthesis and impaired delayed hypersensitivity in atopy. Dinoprostone 44-60 interferon gamma Homo sapiens 80-89 8378773-1 1993 Interferon-alpha (IFN-alpha) and IFN-gamma regulate gene expression by tyrosine phosphorylation of several transcription factors that have the 91-kilodalton (p91) protein of interferon-stimulated gene factor-3 (ISGF-3) as a common component. Tyrosine 71-79 interferon gamma Homo sapiens 33-42 8397512-4 1993 We have tested the hypothesis that GTP-binding proteins (G-proteins) may couple the IFN-gamma-R to PLA2 in the human neuroblastoma (NB) cell line LAN-5. Guanosine Triphosphate 35-38 interferon gamma Homo sapiens 84-93 8397512-5 1993 Incubation of NB cells with IFN-gamma resulted in a rapid increase in [3H]arachidonic acid (AA) release, and this effect was blocked by pretreatment with anti-IFN-gamma antibodies. [3h]arachidonic acid 70-90 interferon gamma Homo sapiens 28-37 8397256-1 1993 The monocyte-derived inflammatory mediator, prostaglandin E2 (PGE2), can reduce IFN-gamma production, and this in turn may relate to IL-4 up-regulation of IgE synthesis and impaired delayed hypersensitivity in atopy. Dinoprostone 62-66 interferon gamma Homo sapiens 80-89 8397512-5 1993 Incubation of NB cells with IFN-gamma resulted in a rapid increase in [3H]arachidonic acid (AA) release, and this effect was blocked by pretreatment with anti-IFN-gamma antibodies. [3h]arachidonic acid 70-90 interferon gamma Homo sapiens 159-168 8397512-9 1993 IFN-gamma-stimulated AA release was completely blocked by the guanine nucleotide analogue that inhibits G-protein function, guanosine 5"-[beta-thio]diphosphate (GDP[S]). Guanine Nucleotides 62-80 interferon gamma Homo sapiens 0-9 8397256-3 1993 In this study, we assessed the relationship between PGE2 and IFN-gamma production along with abnormal PDE activity in AD monocytes. Dinoprostone 52-56 interferon gamma Homo sapiens 61-70 8397512-9 1993 IFN-gamma-stimulated AA release was completely blocked by the guanine nucleotide analogue that inhibits G-protein function, guanosine 5"-[beta-thio]diphosphate (GDP[S]). 6-thioguanosine 5'-diphosphate 124-159 interferon gamma Homo sapiens 0-9 8397512-9 1993 IFN-gamma-stimulated AA release was completely blocked by the guanine nucleotide analogue that inhibits G-protein function, guanosine 5"-[beta-thio]diphosphate (GDP[S]). Guanosine Diphosphate 161-164 interferon gamma Homo sapiens 0-9 8397256-6 1993 In contrast, purified AD T cells, after removal of PGE2-producing monocytes, produced levels of IFN-gamma significantly higher than in normal T cell cultures. Dinoprostone 51-55 interferon gamma Homo sapiens 96-105 8397512-10 1993 A role for G-proteins in IFN-gamma-R coupling to PLA2 was further supported by the inhibition of IFN-gamma-induced [3H]AA release by treatment of permeabilized cells with pertussis toxin and with the antiserum against the common alpha-subunits of G-proteins. Tritium 116-118 interferon gamma Homo sapiens 25-34 8397256-7 1993 Inhibition of PGE2 synthesis by indomethacin caused increased IFN-gamma production by MNL cultures. Dinoprostone 14-18 interferon gamma Homo sapiens 62-71 8397512-10 1993 A role for G-proteins in IFN-gamma-R coupling to PLA2 was further supported by the inhibition of IFN-gamma-induced [3H]AA release by treatment of permeabilized cells with pertussis toxin and with the antiserum against the common alpha-subunits of G-proteins. Tritium 116-118 interferon gamma Homo sapiens 97-106 8397256-7 1993 Inhibition of PGE2 synthesis by indomethacin caused increased IFN-gamma production by MNL cultures. Indomethacin 32-44 interferon gamma Homo sapiens 62-71 8397256-10 1993 This study demonstrates a regulatory interaction between monocytes and T cells in AD and suggests that PGE2 may be an extracellular messenger between these cells to modulate IFN-gamma production. Dinoprostone 103-107 interferon gamma Homo sapiens 174-183 7690156-2 1993 The ability of IFN-gamma to inhibit replication of ectromelia, vaccinia, and herpes simplex-1 viruses in mouse macrophages correlated with the cells" production of nitric oxide (NO). Nitric Oxide 164-176 interferon gamma Homo sapiens 15-24 8358721-4 1993 Moreover, H-8, a PKA inhibitor, enhanced such IFN-gamma-induced HLA-DR expression. N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide 10-13 interferon gamma Homo sapiens 46-55 8358721-12 1993 Moreover, when added to IFN-gamma without TPA in normal thyroid cells, staurosporine increased 3- to 4-fold the amount of HLA-DR. Staurosporine 71-84 interferon gamma Homo sapiens 24-33 8248272-2 1993 HUVEC which had been preincubated with LPS, interleukin-1 alpha (IL-1 alpha), IL-1 beta, tumor necrosis factor (TNF alpha), or interferon-gamma (IFN-gamma) produced more PGI2 than control cells in response to thrombin. Epoprostenol 170-174 interferon gamma Homo sapiens 127-143 10779310-0 1993 Treatment of steroid-dependent asthma with recombinant interferon-gamma. Steroids 13-20 interferon gamma Homo sapiens 55-71 8242087-0 1993 Dinucleotide repeat polymorphism in the interferon-gamma (IFNG) gene. Dinucleoside Phosphates 0-12 interferon gamma Homo sapiens 40-56 8242087-0 1993 Dinucleotide repeat polymorphism in the interferon-gamma (IFNG) gene. Dinucleoside Phosphates 0-12 interferon gamma Homo sapiens 58-62 8134165-5 1993 The cytokine interferon-gamma (IFN-gamma) has been shown to enhance O2- production in MDM. Superoxides 68-70 interferon gamma Homo sapiens 13-29 8134165-5 1993 The cytokine interferon-gamma (IFN-gamma) has been shown to enhance O2- production in MDM. Superoxides 68-70 interferon gamma Homo sapiens 31-40 8134165-6 1993 When GSD 1b MDM were cultured in the presence of IFN-gamma (1 x 10(5) U/L), O2- production in response to fMet-Leu-Phe, concanavalin A, and PMA was enhanced to rates similar to those of control MDM cultured in the presence of IFN-gamma. Superoxides 76-78 interferon gamma Homo sapiens 49-58 8134165-6 1993 When GSD 1b MDM were cultured in the presence of IFN-gamma (1 x 10(5) U/L), O2- production in response to fMet-Leu-Phe, concanavalin A, and PMA was enhanced to rates similar to those of control MDM cultured in the presence of IFN-gamma. Superoxides 76-78 interferon gamma Homo sapiens 226-235 8134165-6 1993 When GSD 1b MDM were cultured in the presence of IFN-gamma (1 x 10(5) U/L), O2- production in response to fMet-Leu-Phe, concanavalin A, and PMA was enhanced to rates similar to those of control MDM cultured in the presence of IFN-gamma. Leucine 111-114 interferon gamma Homo sapiens 49-58 8134165-6 1993 When GSD 1b MDM were cultured in the presence of IFN-gamma (1 x 10(5) U/L), O2- production in response to fMet-Leu-Phe, concanavalin A, and PMA was enhanced to rates similar to those of control MDM cultured in the presence of IFN-gamma. Phenylalanine 115-118 interferon gamma Homo sapiens 49-58 8140295-2 1993 Stimulated by our previous findings that high levels of interferon-gamma (IFN-gamma) occur in this disease and that calcitriol reduces IFN-gamma production by peripheral blood mononuclear cells (PBMC) from normal subjects, we designed the present study to evaluate IFN-gamma production and the effect of calcitriol on the release of this cytokine by PBMC in S patients. Calcitriol 116-126 interferon gamma Homo sapiens 135-144 8140295-2 1993 Stimulated by our previous findings that high levels of interferon-gamma (IFN-gamma) occur in this disease and that calcitriol reduces IFN-gamma production by peripheral blood mononuclear cells (PBMC) from normal subjects, we designed the present study to evaluate IFN-gamma production and the effect of calcitriol on the release of this cytokine by PBMC in S patients. Calcitriol 116-126 interferon gamma Homo sapiens 135-144 8140295-4 1993 Our results show that SEA- and A23187-stimulated PBMC from patients with S released significantly less IFN-gamma than those from control subjects. Calcimycin 31-37 interferon gamma Homo sapiens 103-112 8140295-5 1993 Calcitriol at 10(-6) M and 10(-9) M concentrations reduced IFN-gamma production by SEA-stimulated PBMC but this inhibitory effect was lower in S patients than controls. Calcitriol 0-10 interferon gamma Homo sapiens 59-68 8259703-3 1993 The administration of polyadenylic.polyuridylic acid to the patients has resulted in significant increases of in vitro proliferations of their peripheral blood mononuclear cells as well as productions of interferon-gamma by these cells. polyadenylic. 22-35 interferon gamma Homo sapiens 204-220 8259703-3 1993 The administration of polyadenylic.polyuridylic acid to the patients has resulted in significant increases of in vitro proliferations of their peripheral blood mononuclear cells as well as productions of interferon-gamma by these cells. Poly U 35-52 interferon gamma Homo sapiens 204-220 8349687-6 1993 IFN gamma also induced dimerization of IFN gamma receptors expressed at the cell surface as detected by chemically cross-linking receptor bound ligand and analyzing cell lysates by SDS-polyacrylamide gel electrophoresis and immunoblotting. Sodium Dodecyl Sulfate 181-184 interferon gamma Homo sapiens 0-9 8349687-6 1993 IFN gamma also induced dimerization of IFN gamma receptors expressed at the cell surface as detected by chemically cross-linking receptor bound ligand and analyzing cell lysates by SDS-polyacrylamide gel electrophoresis and immunoblotting. Sodium Dodecyl Sulfate 181-184 interferon gamma Homo sapiens 39-48 8349687-6 1993 IFN gamma also induced dimerization of IFN gamma receptors expressed at the cell surface as detected by chemically cross-linking receptor bound ligand and analyzing cell lysates by SDS-polyacrylamide gel electrophoresis and immunoblotting. polyacrylamide 185-199 interferon gamma Homo sapiens 0-9 8349687-6 1993 IFN gamma also induced dimerization of IFN gamma receptors expressed at the cell surface as detected by chemically cross-linking receptor bound ligand and analyzing cell lysates by SDS-polyacrylamide gel electrophoresis and immunoblotting. polyacrylamide 185-199 interferon gamma Homo sapiens 39-48 8248272-2 1993 HUVEC which had been preincubated with LPS, interleukin-1 alpha (IL-1 alpha), IL-1 beta, tumor necrosis factor (TNF alpha), or interferon-gamma (IFN-gamma) produced more PGI2 than control cells in response to thrombin. Epoprostenol 170-174 interferon gamma Homo sapiens 145-154 8342904-0 1993 Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression. Prednisolone 0-12 interferon gamma Homo sapiens 128-144 8102154-6 1993 The production of IFN-gamma by IL-12-stimulated neonatal T cells is associated with a small but significant T cell activation evidenced by DNA synthesis and by the expression of the activation markers CD25, CD71, and HLA-DR; moreover, it is inhibited by hydrocortisone, cyclosporin A, and transforming growth factor-beta. Hydrocortisone 254-268 interferon gamma Homo sapiens 18-27 8102154-6 1993 The production of IFN-gamma by IL-12-stimulated neonatal T cells is associated with a small but significant T cell activation evidenced by DNA synthesis and by the expression of the activation markers CD25, CD71, and HLA-DR; moreover, it is inhibited by hydrocortisone, cyclosporin A, and transforming growth factor-beta. Cyclosporine 270-283 interferon gamma Homo sapiens 18-27 8102154-8 1993 Using a three-step culture system, we next show that IL-12 induces the maturation of resting naive CD4 T cells into cells producing both IL-2 and IFN-gamma but not IL-4 upon stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 191-194 interferon gamma Homo sapiens 146-155 7688311-4 1993 IL-10 further increased NO2- production by M phi stimulated in the presence of optimal concentrations of prostaglandin E2, a positive modulator of M phi activation by IFN-gamma/TNF-alpha. Nitrogen Dioxide 24-27 interferon gamma Homo sapiens 167-176 8334680-2 1993 In the blood cell cultures of the 16 patients who received 5-fluorouracil and leucovorin IFN gamma levels decreased (P < or = 0.01) and TNF alpha levels rose (P < or = 0.05) during each therapy cycle. Leucovorin 78-88 interferon gamma Homo sapiens 89-98 7688311-4 1993 IL-10 further increased NO2- production by M phi stimulated in the presence of optimal concentrations of prostaglandin E2, a positive modulator of M phi activation by IFN-gamma/TNF-alpha. Dinoprostone 105-121 interferon gamma Homo sapiens 167-176 7688311-0 1993 Induction of macrophage nitric oxide production by interferon-gamma and tumor necrosis factor-alpha is enhanced by interleukin-10. Nitric Oxide 24-36 interferon gamma Homo sapiens 51-99 8406584-6 1993 Murine IFN-gamma R-IgG is secreted by transfected cells as a disulphide-bonded homodimer which binds IFN-gamma bivalently, with high affinity and in a species-specific manner. disulphide 61-71 interferon gamma Homo sapiens 7-16 8228387-0 1993 Effect of carbohydrates on the pharmacokinetics of human interferon-gamma. Carbohydrates 10-23 interferon gamma Homo sapiens 57-73 7901291-4 1993 Poly(I:C) mediated reversal of the IFN-gamma-resistant phenotype and induction of IDO mRNA are inhibited by 2-aminopurine. Poly I-C 0-8 interferon gamma Homo sapiens 35-44 7901291-4 1993 Poly(I:C) mediated reversal of the IFN-gamma-resistant phenotype and induction of IDO mRNA are inhibited by 2-aminopurine. 2-Aminopurine 108-121 interferon gamma Homo sapiens 35-44 8228387-1 1993 Human interferon-gamma (IFN-gamma) has two N-linked glycosylation sites at positions 25 and 97 of the 143-amino-acid-long secretory form. Nitrogen 26-27 interferon gamma Homo sapiens 6-22 8228387-9 1993 The results emphasize the importance of the carbohydrate groups in human IFN-gamma to its pharmacokinetic properties. Carbohydrates 44-56 interferon gamma Homo sapiens 73-82 8233727-11 1993 Considering the low proportion of lymphocytes, stimulation with phorbol myristate acetate in combination with ionomycin resulted in considerable production of the following lymphokines: IL-2, IL-3, IL-4, IL-10, interferon-gamma, tumor necrosis factor-alpha. Tetradecanoylphorbol Acetate 64-89 interferon gamma Homo sapiens 211-256 8335941-2 1993 In our study, using microglial/neuronal cell cocultures primed with IFN-gamma, we found that both LPS and TNF-alpha triggered neuronal cell injury (impairment of gamma-aminobutyric acid uptake and neuronal loss) via a nitric oxide mechanism. gamma-Aminobutyric Acid 162-185 interferon gamma Homo sapiens 68-77 8335941-2 1993 In our study, using microglial/neuronal cell cocultures primed with IFN-gamma, we found that both LPS and TNF-alpha triggered neuronal cell injury (impairment of gamma-aminobutyric acid uptake and neuronal loss) via a nitric oxide mechanism. Nitric Oxide 218-230 interferon gamma Homo sapiens 68-77 8233727-11 1993 Considering the low proportion of lymphocytes, stimulation with phorbol myristate acetate in combination with ionomycin resulted in considerable production of the following lymphokines: IL-2, IL-3, IL-4, IL-10, interferon-gamma, tumor necrosis factor-alpha. Ionomycin 110-119 interferon gamma Homo sapiens 211-256 8325338-6 1993 Apoptosis could also be prevented by cyclosporin A (CsA) treatment and could be re-induced by the addition of IFN-gamma to CsA-treated cells. Cyclosporine 123-126 interferon gamma Homo sapiens 110-119 8319179-10 1993 This inhibitory effect of PGE2 was noticeable in long-term LAK cultures and was abrogated in the presence of IFN-gamma or indomethacin. Dinoprostone 26-30 interferon gamma Homo sapiens 109-118 8333847-3 1993 Moreover, N-monomethyl-L-arginine a competitive inhibitor of NO synthase blocked TNF-alpha and IFN-gamma-dependent proliferation and NO induction on C6 cells, but had no effect on IL-6-dependent proliferation. omega-N-Methylarginine 10-33 interferon gamma Homo sapiens 95-104 8100773-5 1993 SAg binding to Ag-specific TCL resulted in a rapid mobilization of intracellular free calcium ([Ca2+]i) and transcription of a number of cytokine genes including interleukin-2(IL-2), IL-4, interferon-gamma (IFN-gamma), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granzyme B indicating the activation of primed T cells. Triclosan 27-30 interferon gamma Homo sapiens 189-205 8100773-5 1993 SAg binding to Ag-specific TCL resulted in a rapid mobilization of intracellular free calcium ([Ca2+]i) and transcription of a number of cytokine genes including interleukin-2(IL-2), IL-4, interferon-gamma (IFN-gamma), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granzyme B indicating the activation of primed T cells. Triclosan 27-30 interferon gamma Homo sapiens 207-216 8315390-3 1993 Whereas in vivo administration of ovalbumin (OVA) induces cytokine synthesis that is neither Th1 nor Th2 dominated, administration of glutaraldehyde polymerized, high relative molecular weight OVA (OA-POL) leads to 20-fold increase in the ratio of interferon gamma (IFN-gamma)/IL-4 and IFN-gamma/IL-10 synthesis observed after short-term, antigen-mediated restimulation directly ex vivo. Glutaral 134-148 interferon gamma Homo sapiens 248-275 8314853-2 1993 [1989] FEBS Lett., 250:622-624), the interferon-gamma induced neopterin production by human monocytes/macrophages (Huber et al. Neopterin 62-71 interferon gamma Homo sapiens 37-53 7689587-6 1993 The IL-1 beta-induced nitrite production by astrocytes was markedly enhanced when cells were co-stimulated with IFN-gamma or TNF-alpha (IFN-gamma > TNF-alpha); LPS had no effect used as a single agent or in combination with other cytokines. Nitrites 22-29 interferon gamma Homo sapiens 112-121 7689587-6 1993 The IL-1 beta-induced nitrite production by astrocytes was markedly enhanced when cells were co-stimulated with IFN-gamma or TNF-alpha (IFN-gamma > TNF-alpha); LPS had no effect used as a single agent or in combination with other cytokines. Nitrites 22-29 interferon gamma Homo sapiens 136-145 8355466-6 1993 The synthesis of C4 by PTEC and its regulation by IFN-gamma was fully inhibitable by the addition of cycloheximide, indicating that protein synthesis is required for an increase in C4 secretion. Cycloheximide 101-114 interferon gamma Homo sapiens 50-59 8321205-2 1993 In a membrane-enriched fraction prepared from human peripheral blood monocytes, IFN-gamma activation of FcRF gamma occurred within 1 min and was ATP dependent. Adenosine Triphosphate 145-148 interferon gamma Homo sapiens 80-89 8315390-3 1993 Whereas in vivo administration of ovalbumin (OVA) induces cytokine synthesis that is neither Th1 nor Th2 dominated, administration of glutaraldehyde polymerized, high relative molecular weight OVA (OA-POL) leads to 20-fold increase in the ratio of interferon gamma (IFN-gamma)/IL-4 and IFN-gamma/IL-10 synthesis observed after short-term, antigen-mediated restimulation directly ex vivo. Glutaral 134-148 interferon gamma Homo sapiens 266-275 8323563-5 1993 These results suggest that an increase of poly(ADP-ribose) synthetase by norepinephrine cause the inhibition of interferon-gamma-mediated MHC class II antigen expression. Norepinephrine 73-87 interferon gamma Homo sapiens 112-128 8390534-2 1993 We demonstrate that PGE2 selectively and dose dependently inhibits IL-2 and IFN-gamma production by mitogenically stimulated human PBL and CD4+ TLC, although at low concentrations IL-4 production is not affected and IL-5 production is even up-regulated. Dinoprostone 20-24 interferon gamma Homo sapiens 76-85 8333042-11 1993 Immunomodulatory properties of PTX were not only associated with blockage of TNF-alpha, as shown by decreased mRNA expression and TNF-alpha values in the culture supernatants, but also with an impaired production of other cytokines and secondary messages such as IFN-gamma and neopterin. Pentoxifylline 31-34 interferon gamma Homo sapiens 263-272 8515061-7 1993 Although the activation of IFN-gamma-primed macrophages by viable resting Th2 displays Ag specificity and MHC restriction, the activation of IFN-gamma-primed macrophages by paraformaldehyde-fixed activated Th2 is neither Ag specific nor MHC restricted. paraform 173-189 interferon gamma Homo sapiens 141-150 8390534-4 1993 The action of PGE2 may, therefore, be associated with elevation of intracellular cAMP levels, affecting IL-4 and IL-5 differentially from IL-2 and IFN-gamma production. Dinoprostone 14-18 interferon gamma Homo sapiens 147-156 8390537-8 1993 Primary amines also inhibited IL-1-induced increases in ELAM-1, ICAM-1, and VCAM-1 measured 4 to 6 h after treatment and inhibited IFN-beta- and IFN-gamma-mediated induction of class I MHC molecules and IFN-gamma-mediated induction of class II MHC molecules measured 72 h after treatment with cytokine. Amines 8-14 interferon gamma Homo sapiens 145-154 8390537-8 1993 Primary amines also inhibited IL-1-induced increases in ELAM-1, ICAM-1, and VCAM-1 measured 4 to 6 h after treatment and inhibited IFN-beta- and IFN-gamma-mediated induction of class I MHC molecules and IFN-gamma-mediated induction of class II MHC molecules measured 72 h after treatment with cytokine. Amines 8-14 interferon gamma Homo sapiens 203-212 8103344-3 1993 Calcium ionophore A23187 significantly enhanced IFN-gamma- and PMA-induced ICAM-1 staining. Calcium 0-7 interferon gamma Homo sapiens 48-57 8103344-3 1993 Calcium ionophore A23187 significantly enhanced IFN-gamma- and PMA-induced ICAM-1 staining. Calcimycin 18-24 interferon gamma Homo sapiens 48-57 8103344-4 1993 While staurosporine, H7 and sphingosine, three known PKC inhibitors, blocked the PMA effect, only staurosporine abrogated the action of IFN-gamma. Staurosporine 98-111 interferon gamma Homo sapiens 136-145 8099851-2 1993 Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 171-196 interferon gamma Homo sapiens 0-16 8099851-2 1993 Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 198-201 interferon gamma Homo sapiens 0-16 7684703-5 1993 In addition, it was shown that the effects of IFN-gamma on LPS-induced G-CSF protein secretion could be mimicked by the calcium ionophore A23187, suggesting that the Ca(2+)-dependent pathway might be triggered after binding of the ligand to the receptor. Calcium 120-127 interferon gamma Homo sapiens 46-55 7684703-5 1993 In addition, it was shown that the effects of IFN-gamma on LPS-induced G-CSF protein secretion could be mimicked by the calcium ionophore A23187, suggesting that the Ca(2+)-dependent pathway might be triggered after binding of the ligand to the receptor. Calcimycin 138-144 interferon gamma Homo sapiens 46-55 8344703-7 1993 C3 mRNA levels were increased in A549 cells treated with IFN-gamma and dexamethasone individually and in combination suggesting that IFN-gamma and dexamethasone increase C3 synthesis by a pre-translational mechanism. Dexamethasone 71-84 interferon gamma Homo sapiens 133-142 8394173-0 1993 Synergistic effect of interferon-gamma and phorbol myristate acetate on superoxide production by human monocytes. Superoxides 72-82 interferon gamma Homo sapiens 22-38 8394173-1 1993 This study demonstrates a synergistic effect of IFN gamma and PMA on superoxide generation by human monocytes. Superoxides 69-79 interferon gamma Homo sapiens 48-57 8394173-4 1993 However, exposure of the cells to IFN gamma for 10 to 15 hr prior to PMA treatment enhanced both superoxide production and PK-C activation. Superoxides 97-107 interferon gamma Homo sapiens 34-43 8394173-5 1993 Using protein kinase inhibitors, we noticed that while PMA exerted its effect by activating PK-C, IFN gamma operated via activation of calcium/calmodulin-dependent or some other calcium-dependent protein kinases. Tetradecanoylphorbol Acetate 55-58 interferon gamma Homo sapiens 98-107 8394173-6 1993 These kinases appeared to be involved in the effect of IFN gamma on superoxide production, as well as in its potentiation of PMA activity. Superoxides 68-78 interferon gamma Homo sapiens 55-64 8344703-7 1993 C3 mRNA levels were increased in A549 cells treated with IFN-gamma and dexamethasone individually and in combination suggesting that IFN-gamma and dexamethasone increase C3 synthesis by a pre-translational mechanism. Dexamethasone 147-160 interferon gamma Homo sapiens 57-66 8396165-4 1993 Adherence-isolated peripheral blood monocytes were exposed to recombinant human IFN-gamma at 0.1-300 U/ml in Gey"s balanced salt solution for varying time periods. gey"s balanced salt solution 109-137 interferon gamma Homo sapiens 80-89 8390485-3 1993 We found that IFN-gamma induced a concentration-dependent increase in the capacity of human monocyte-derived macrophages to ingest and kill both opsonized and unopsonized Candida albicans and to release superoxide anion upon stimulation with Candida. Superoxides 203-219 interferon gamma Homo sapiens 14-23 8396165-9 1993 IFN-gamma of PDE activity may alter normal monocyte functions by decreasing cyclic AMP levels. Cyclic AMP 76-86 interferon gamma Homo sapiens 0-9 8323465-7 1993 IFN gamma was detected in only 3 patients (16% of the LMIT-positive patients), i.e., in 2 patients in the LMAF-positive group and one patient in the LMIF-positive group. lmaf 106-110 interferon gamma Homo sapiens 0-9 8502244-4 1993 The addition of actinomycin D (ActD), a transcriptional inhibitor, together with either PMA or IFN-gamma diminishes the enhanced levels of CD32C mRNA to the basal levels, indicating that transcriptional regulation is involved in this modulatory process. Dactinomycin 16-29 interferon gamma Homo sapiens 95-104 8502244-5 1993 The addition of cyclohexamide (CX), a protein synthesis inhibitor, to cultures undergoing stimulation with either PMA or IFN-gamma, increased the levels of CD32C mRNA synthesis suggesting that regulatory degradation proteins may be involved. 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione 16-29 interferon gamma Homo sapiens 121-130 8502244-5 1993 The addition of cyclohexamide (CX), a protein synthesis inhibitor, to cultures undergoing stimulation with either PMA or IFN-gamma, increased the levels of CD32C mRNA synthesis suggesting that regulatory degradation proteins may be involved. Cycloheximide 31-33 interferon gamma Homo sapiens 121-130 8334107-0 1993 Purification and characterization of interferon-gamma-inducing molecule of OK-432, a penicillin-killed streptococcal preparation, by monoclonal antibody neutralizing interferon-gamma-inducing activity of OK-432. Penicillins 85-95 interferon gamma Homo sapiens 37-53 8334107-5 1993 The polysaccharide sample carrying the IFN-gamma-inducing activity with a molecular weight of 700,000 was destroyed by treatment with acid or sodium metaperiodate, but was stable to treatment with heat, alkali, pronase, or neuraminidase. Polysaccharides 4-18 interferon gamma Homo sapiens 39-48 8334107-5 1993 The polysaccharide sample carrying the IFN-gamma-inducing activity with a molecular weight of 700,000 was destroyed by treatment with acid or sodium metaperiodate, but was stable to treatment with heat, alkali, pronase, or neuraminidase. acid or 134-141 interferon gamma Homo sapiens 39-48 8334107-5 1993 The polysaccharide sample carrying the IFN-gamma-inducing activity with a molecular weight of 700,000 was destroyed by treatment with acid or sodium metaperiodate, but was stable to treatment with heat, alkali, pronase, or neuraminidase. metaperiodate 142-162 interferon gamma Homo sapiens 39-48 8334107-8 1993 These findings indicate that the polysaccharide sample purified by the affinity chromatography of butanol extract of OK-432 on CNBr-activated Sepharose 4B-bound TS-2 MAb carries the IFN-gamma-inducing activity of OK-432 and marked antitumor activity. Polysaccharides 33-47 interferon gamma Homo sapiens 182-191 8334107-8 1993 These findings indicate that the polysaccharide sample purified by the affinity chromatography of butanol extract of OK-432 on CNBr-activated Sepharose 4B-bound TS-2 MAb carries the IFN-gamma-inducing activity of OK-432 and marked antitumor activity. Butanols 98-105 interferon gamma Homo sapiens 182-191 8334107-8 1993 These findings indicate that the polysaccharide sample purified by the affinity chromatography of butanol extract of OK-432 on CNBr-activated Sepharose 4B-bound TS-2 MAb carries the IFN-gamma-inducing activity of OK-432 and marked antitumor activity. Sepharose 142-151 interferon gamma Homo sapiens 182-191 8323465-7 1993 IFN gamma was detected in only 3 patients (16% of the LMIT-positive patients), i.e., in 2 patients in the LMAF-positive group and one patient in the LMIF-positive group. lmif 149-153 interferon gamma Homo sapiens 0-9 8394282-3 1993 Pretreatment of EoL-1 cells with dbcAMP induced EoL-1 cells to express Fc gamma RIII when stimulated with IFN-gamma, but EoL-1 cells pretreated with IFN-gamma and then stimulated with dbcAMP failed to express Fc gamma RIII. Bucladesine 33-39 interferon gamma Homo sapiens 106-115 8394282-7 1993 Dibutyryl cAMP did not induce Fc gamma RIII expression and even suppressed the IFN-gamma-induced Fc gamma RIII expression on normal eosinophils. dibutyryl 0-9 interferon gamma Homo sapiens 79-88 8394282-0 1993 Induction of phosphatidylinositol-linked Fc gamma receptor III expression on an eosinophilic cell line, EoL-1, by dibutyryl cyclic AMP and interferon-gamma. Phosphatidylinositols 13-33 interferon gamma Homo sapiens 139-155 8394282-7 1993 Dibutyryl cAMP did not induce Fc gamma RIII expression and even suppressed the IFN-gamma-induced Fc gamma RIII expression on normal eosinophils. Cyclic AMP 10-14 interferon gamma Homo sapiens 79-88 7687031-0 1993 Effect of interferon-gamma on ACNU-induced DNA damage and cytotoxicity in human glioblastoma cells. Nimustine 30-34 interferon gamma Homo sapiens 10-26 8391545-11 1993 Preincubation of FLS with 100 U/ml of IFN-gamma resulted in a 28.9 +/- 9.0% increase in TNF-alpha receptor expression (P < 0.008), with no change in the Kd. CHEMBL1232769 17-20 interferon gamma Homo sapiens 38-47 7687031-2 1993 The direct effects of IFN-gamma on (1-4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU)-induced deoxyribonucleic acid (DNA) damage and cytotoxicity were investigated in two human glioblastoma cell lines, A-172 and T98G, using a single cell microgel electrophoresis technique and a microculture tetrazolium assay. (1-4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride 35-121 interferon gamma Homo sapiens 22-31 7687031-6 1993 DNA damage in individual A-172 and T98G cells exposed to ACNU was enhanced significantly by IFN-gamma (p < 0.001). Nimustine 57-61 interferon gamma Homo sapiens 92-101 7687031-7 1993 The findings suggest a direct effect of IFN-gamma on ACNU-induced cell damage in human glioma, in addition to its effect on immunomodulation. Nimustine 53-57 interferon gamma Homo sapiens 40-49 8353647-7 1993 Compared to controls IFN-gamma production of peripheral mononuclear cells (PBMC) from newborns with elevated cord blood IgE was not different, but PMBC from newborns with a familial risk showed a significant decrease in PHA induced IFN-gamma production (p < 0.005, U-test). pmbc 147-151 interferon gamma Homo sapiens 232-241 7683442-8 1993 The AChR and subunit-reactive T cells could--via secretion of effector molecules including IFN-gamma--play an important role in the initiation and perpetuation of EAMG, and consequently also of human myasthenia gravis. eamg 163-167 interferon gamma Homo sapiens 91-100 8391076-2 1993 Here we review our findings on the ability of IFN-gamma and IL-4 to modulate this signal transduction pathway as a result of the effect of these cytokines on eicosanoid synthesis. Eicosanoids 158-168 interferon gamma Homo sapiens 46-55 8391076-3 1993 Preincubation for 1 hour with either IFN-gamma or IL-4 prior to stimulation with Con A caused a significant inhibition of M phi PGE2 production. Dinoprostone 128-132 interferon gamma Homo sapiens 37-46 8391076-5 1993 The inhibition of M phi metalloproteinase production by IFN-gamma and IL-4 was reversed by PGE2 or Bt2cAMP. Dinoprostone 91-95 interferon gamma Homo sapiens 56-65 8391076-5 1993 The inhibition of M phi metalloproteinase production by IFN-gamma and IL-4 was reversed by PGE2 or Bt2cAMP. Bucladesine 99-106 interferon gamma Homo sapiens 56-65 8391076-6 1993 Thus the suppression of eicosanoid synthesis by IFN-gamma and IL-4 is the primary mechanism by which these cytokines inhibit M phi metalloproteinase production. Eicosanoids 24-34 interferon gamma Homo sapiens 48-57 8468486-2 1993 Although undifferentiated cells did not produce PAF, the exposure of IFN-gamma differentiated Eol-1 to generate PAF in response to the Ca-ionophore. Platelet Activating Factor 112-115 interferon gamma Homo sapiens 69-78 8385632-1 1993 Neopterin, a pyrazino-pyrimidine derivative, is synthesized in excess by human monocytes/macrophages upon stimulation with interferon-gamma, a cytokine derived from activated I cells. Neopterin 0-9 interferon gamma Homo sapiens 123-139 8386028-2 1993 We have examined whether monocytes from children with chronic granulomatous disease (CGD) can be primed by cytokines other than interferon-gamma (IFN gamma), which has been demonstrated to improve the production of reactive oxygen species in vivo and in vitro. Reactive Oxygen Species 215-238 interferon gamma Homo sapiens 146-155 8468486-3 1993 In addition, the IFN-gamma-treated cells acquired the ability to release free fatty acids, approximately 55% of which was found to be AA. Fatty Acids, Nonesterified 73-89 interferon gamma Homo sapiens 17-26 8471780-7 1993 IFN-gamma treatment at the same time rendered these cells susceptible to lysis by MiHA-specific TCL. miha-specific tcl 82-99 interferon gamma Homo sapiens 0-9 8096142-14 1993 CONCLUSIONS: Intercellular adhesion molecule 1 is constitutively expressed on H&N SCC cell lines, with enhanced expression seen after treatment with interferon gamma and other cytokines. Adenosine Monophosphate 93-96 interferon gamma Homo sapiens 166-182 8490205-0 1993 Antiproliferative and chemomodulatory effects of interferon-gamma on doxorubicin-sensitive and -resistant tumor cell lines. Doxorubicin 69-80 interferon gamma Homo sapiens 49-65 8490205-6 1993 On the other hand, this activity was enhanced by co-treatment with glutathione-depleting concentrations of buthionine sulfoximine, but only in the cell lines which had responded better to IFN-gamma alone. Glutathione 67-78 interferon gamma Homo sapiens 188-197 8490205-6 1993 On the other hand, this activity was enhanced by co-treatment with glutathione-depleting concentrations of buthionine sulfoximine, but only in the cell lines which had responded better to IFN-gamma alone. Buthionine Sulfoximine 107-129 interferon gamma Homo sapiens 188-197 8517803-12 1993 PGE2 release did not differ between groups at the initial donation, although there was a depression in PGE2 release in the susceptible group at the final donation when IFN-gamma was followed by S. typhimurium LPS. Dinoprostone 103-107 interferon gamma Homo sapiens 168-177 8471029-0 1993 4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells). 4-chloro-3-hydroxyanthranilic acid 0-30 interferon gamma Homo sapiens 105-121 8471029-0 1993 4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells). 6-chlorotryptophan 32-50 interferon gamma Homo sapiens 105-121 8471029-0 1993 4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells). norharman 55-65 interferon gamma Homo sapiens 105-121 8471029-0 1993 4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells). Quinolinic Acid 76-91 interferon gamma Homo sapiens 105-121 8364980-4 1993 The results showed that the c-myc gene was spontaneously expressed in EoL-1, and the level of c-myc mRNA was markedly reduced after the cells were cocultured with TNF and IFN-gamma, suggesting that the decrease of the c-myc mRNA level is closely associated with induction of the ability to release H2O2. Hydrogen Peroxide 298-302 interferon gamma Homo sapiens 171-180 7683267-8 1993 Immunocytochemistry demonstrated that FK506 reduced the expression of interferon-gamma induced major histocompatibility complex (MHC) class I on the proximal tubular cells, but had no effect on the expression of the MHC class II antigens or the intercellular adhesion molecule (ICAM-1) on the cultured cells. Tacrolimus 38-43 interferon gamma Homo sapiens 70-86 8099569-7 1993 Blocking studies using anti-interferon-gamma (anti-IFN-gamma) monoclonal antibodies (mAb), anti-interleukin 4 (anti-IL-4) mAb, and indomethacin suggested that IFN-gamma, IL-4, and PGE2 contributed to tumor-induced M phi-mediated suppression. Indomethacin 131-143 interferon gamma Homo sapiens 159-168 8099569-7 1993 Blocking studies using anti-interferon-gamma (anti-IFN-gamma) monoclonal antibodies (mAb), anti-interleukin 4 (anti-IL-4) mAb, and indomethacin suggested that IFN-gamma, IL-4, and PGE2 contributed to tumor-induced M phi-mediated suppression. Dinoprostone 180-184 interferon gamma Homo sapiens 159-168 8387619-6 1993 Interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) also had an inhibitory effect for KY-821 and KY-MTX, but lacked such effect in KY-RA and KY-VCR. ky-821 107-113 interferon gamma Homo sapiens 0-16 8392465-0 1993 Leukemia inhibitory factor, interferon gamma and dexamethasone regulate N-glycosylation of alpha 1-protease inhibitor in human hepatoma cells. Nitrogen 72-73 interferon gamma Homo sapiens 28-44 8478984-4 1993 IFN-gamma treatment also induced decreases in [3H]TdR incorporation, as well as serum-dependent changes in cell number. Tritium 47-49 interferon gamma Homo sapiens 0-9 8478984-9 1993 Co-incubation in IFN-gamma (20-100 U/ml) and IGF-II (3-10 nM) prevented the inhibitory effects of IFN-gamma on [3H]TdR incorporation in serum-free media. Tritium 112-114 interferon gamma Homo sapiens 17-26 8478984-9 1993 Co-incubation in IFN-gamma (20-100 U/ml) and IGF-II (3-10 nM) prevented the inhibitory effects of IFN-gamma on [3H]TdR incorporation in serum-free media. Tritium 112-114 interferon gamma Homo sapiens 98-107 8387619-6 1993 Interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) also had an inhibitory effect for KY-821 and KY-MTX, but lacked such effect in KY-RA and KY-VCR. ky-821 107-113 interferon gamma Homo sapiens 18-27 8387619-6 1993 Interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) also had an inhibitory effect for KY-821 and KY-MTX, but lacked such effect in KY-RA and KY-VCR. ky-mtx 118-124 interferon gamma Homo sapiens 0-16 8387619-6 1993 Interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) also had an inhibitory effect for KY-821 and KY-MTX, but lacked such effect in KY-RA and KY-VCR. ky-mtx 118-124 interferon gamma Homo sapiens 18-27 8474431-4 1993 A 24-hr exposure to 1 microM 5-FU resulted in a 4.5-fold increase in the level of TS protein, whereas in 5-FU/IFN-gamma-treated cells TS protein was increased by only 1.8-fold, compared with control cells. Fluorouracil 29-33 interferon gamma Homo sapiens 110-119 8474431-7 1993 Pulse-labeling studies with [35S]methionine demonstrated a 3.5-fold increase in net synthesis of TS in cells treated with 1 microM 5-FU, whereas the level of newly synthesized TS increased only 1.5-fold in cells treated with 5-FU/IFN-gamma, compared with control cells. Fluorouracil 131-135 interferon gamma Homo sapiens 230-239 8474431-9 1993 These findings demonstrate that the increase in TS protein after 5-FU exposure and the subsequent inhibitory effect of IFN-gamma on TS protein expression are both regulated at the post-transcriptional level. Fluorouracil 65-69 interferon gamma Homo sapiens 119-128 8456113-0 1993 Comparative effects of heme and metalloporphyrins on interferon-gamma-mediated pathways in monocytic cells (THP-1). Heme 23-27 interferon gamma Homo sapiens 53-69 8456113-5 1993 In contrast, tin-protoporphyrin enhanced the IFN-gamma effects as seen by increased neopterin production, enhanced tryptophan degradation, and elevated HLA-DR antigen expression on cells. tin protoporphyrin IX 13-31 interferon gamma Homo sapiens 45-54 8456113-5 1993 In contrast, tin-protoporphyrin enhanced the IFN-gamma effects as seen by increased neopterin production, enhanced tryptophan degradation, and elevated HLA-DR antigen expression on cells. Neopterin 84-93 interferon gamma Homo sapiens 45-54 8456113-5 1993 In contrast, tin-protoporphyrin enhanced the IFN-gamma effects as seen by increased neopterin production, enhanced tryptophan degradation, and elevated HLA-DR antigen expression on cells. Tryptophan 115-125 interferon gamma Homo sapiens 45-54 8456113-6 1993 These effects are considered to be due to the action of heme, metalloporphyrins, iron, or heme byproducts on the IFN-gamma signal, rather than to direct effects on IFN-gamma-induced enzymatic pathways. Heme 56-60 interferon gamma Homo sapiens 113-122 8456113-6 1993 These effects are considered to be due to the action of heme, metalloporphyrins, iron, or heme byproducts on the IFN-gamma signal, rather than to direct effects on IFN-gamma-induced enzymatic pathways. Metalloporphyrins 62-79 interferon gamma Homo sapiens 113-122 8456113-6 1993 These effects are considered to be due to the action of heme, metalloporphyrins, iron, or heme byproducts on the IFN-gamma signal, rather than to direct effects on IFN-gamma-induced enzymatic pathways. Iron 81-85 interferon gamma Homo sapiens 113-122 8456113-6 1993 These effects are considered to be due to the action of heme, metalloporphyrins, iron, or heme byproducts on the IFN-gamma signal, rather than to direct effects on IFN-gamma-induced enzymatic pathways. Heme 90-94 interferon gamma Homo sapiens 113-122 8456113-8 1993 These pathways are also known to be influenced by IFN-gamma, and our data suggest that heme and metalloporphyrins may directly modulate the efficiency of the IFN-gamma signal. Heme 87-91 interferon gamma Homo sapiens 50-59 8456113-8 1993 These pathways are also known to be influenced by IFN-gamma, and our data suggest that heme and metalloporphyrins may directly modulate the efficiency of the IFN-gamma signal. Heme 87-91 interferon gamma Homo sapiens 158-167 8456113-8 1993 These pathways are also known to be influenced by IFN-gamma, and our data suggest that heme and metalloporphyrins may directly modulate the efficiency of the IFN-gamma signal. Metalloporphyrins 96-113 interferon gamma Homo sapiens 50-59 8456113-8 1993 These pathways are also known to be influenced by IFN-gamma, and our data suggest that heme and metalloporphyrins may directly modulate the efficiency of the IFN-gamma signal. Metalloporphyrins 96-113 interferon gamma Homo sapiens 158-167 8456113-0 1993 Comparative effects of heme and metalloporphyrins on interferon-gamma-mediated pathways in monocytic cells (THP-1). Metalloporphyrins 32-49 interferon gamma Homo sapiens 53-69 8456113-1 1993 Previous results have demonstrated links between cell-mediated immunity, interferon (IFN)-gamma and neopterin production with heme, porphyrins, and iron metabolism. Heme 126-130 interferon gamma Homo sapiens 73-95 8456113-1 1993 Previous results have demonstrated links between cell-mediated immunity, interferon (IFN)-gamma and neopterin production with heme, porphyrins, and iron metabolism. Porphyrins 132-142 interferon gamma Homo sapiens 73-95 8456113-2 1993 In this study, we compared the effects of heme, several metalloporphyrins, protoporphyrin IX, and iron on the signal or IFN-gamma-mediated pathways, such as the expression of major histocompatibility complex class II antigens, neopterin formation, and the degradation of tryptophan. Heme 42-46 interferon gamma Homo sapiens 120-129 8456113-2 1993 In this study, we compared the effects of heme, several metalloporphyrins, protoporphyrin IX, and iron on the signal or IFN-gamma-mediated pathways, such as the expression of major histocompatibility complex class II antigens, neopterin formation, and the degradation of tryptophan. Metalloporphyrins 56-73 interferon gamma Homo sapiens 120-129 8456113-2 1993 In this study, we compared the effects of heme, several metalloporphyrins, protoporphyrin IX, and iron on the signal or IFN-gamma-mediated pathways, such as the expression of major histocompatibility complex class II antigens, neopterin formation, and the degradation of tryptophan. protoporphyrin IX 75-92 interferon gamma Homo sapiens 120-129 8456113-2 1993 In this study, we compared the effects of heme, several metalloporphyrins, protoporphyrin IX, and iron on the signal or IFN-gamma-mediated pathways, such as the expression of major histocompatibility complex class II antigens, neopterin formation, and the degradation of tryptophan. Iron 98-102 interferon gamma Homo sapiens 120-129 8456113-2 1993 In this study, we compared the effects of heme, several metalloporphyrins, protoporphyrin IX, and iron on the signal or IFN-gamma-mediated pathways, such as the expression of major histocompatibility complex class II antigens, neopterin formation, and the degradation of tryptophan. Neopterin 227-236 interferon gamma Homo sapiens 120-129 8456113-2 1993 In this study, we compared the effects of heme, several metalloporphyrins, protoporphyrin IX, and iron on the signal or IFN-gamma-mediated pathways, such as the expression of major histocompatibility complex class II antigens, neopterin formation, and the degradation of tryptophan. Tryptophan 271-281 interferon gamma Homo sapiens 120-129 8456113-3 1993 Using the human monocytic cell line, THP-1, we found that heme, Zn-mesoporphyrin, Zn-deuteroporphyrin, Co-protoporphyrin, and iron reduced the efficiency of the IFN-gamma signal. Heme 58-62 interferon gamma Homo sapiens 161-170 8456113-3 1993 Using the human monocytic cell line, THP-1, we found that heme, Zn-mesoporphyrin, Zn-deuteroporphyrin, Co-protoporphyrin, and iron reduced the efficiency of the IFN-gamma signal. zn-mesoporphyrin 64-80 interferon gamma Homo sapiens 161-170 8456113-3 1993 Using the human monocytic cell line, THP-1, we found that heme, Zn-mesoporphyrin, Zn-deuteroporphyrin, Co-protoporphyrin, and iron reduced the efficiency of the IFN-gamma signal. zn-deuteroporphyrin 82-101 interferon gamma Homo sapiens 161-170 8456113-3 1993 Using the human monocytic cell line, THP-1, we found that heme, Zn-mesoporphyrin, Zn-deuteroporphyrin, Co-protoporphyrin, and iron reduced the efficiency of the IFN-gamma signal. co-protoporphyrin 103-120 interferon gamma Homo sapiens 161-170 8456113-3 1993 Using the human monocytic cell line, THP-1, we found that heme, Zn-mesoporphyrin, Zn-deuteroporphyrin, Co-protoporphyrin, and iron reduced the efficiency of the IFN-gamma signal. Iron 126-130 interferon gamma Homo sapiens 161-170 8456113-4 1993 In addition, Zn-mesoporphyrin almost fully inhibited IFN-gamma-induced degradation of tryptophan by the heme protein, indoleamine 2,3-dioxygenase. zn-mesoporphyrin 13-29 interferon gamma Homo sapiens 53-62 8456113-4 1993 In addition, Zn-mesoporphyrin almost fully inhibited IFN-gamma-induced degradation of tryptophan by the heme protein, indoleamine 2,3-dioxygenase. Tryptophan 86-96 interferon gamma Homo sapiens 53-62 7680009-4 1993 Actinomycin D abolished the IFN gamma- and TNF alpha-induced increases in iNOS mRNA and nitrite production. Dactinomycin 0-13 interferon gamma Homo sapiens 28-37 7680009-4 1993 Actinomycin D abolished the IFN gamma- and TNF alpha-induced increases in iNOS mRNA and nitrite production. Nitrites 88-95 interferon gamma Homo sapiens 28-37 7680009-5 1993 Cycloheximide, which abolished both the IFN gamma- and TNF alpha-induced increases in nitrite production, had no effect on the IFN gamma-induced increase in iNOS mRNA but markedly inhibited the TNF alpha-induced one. Cycloheximide 0-13 interferon gamma Homo sapiens 40-49 7680009-5 1993 Cycloheximide, which abolished both the IFN gamma- and TNF alpha-induced increases in nitrite production, had no effect on the IFN gamma-induced increase in iNOS mRNA but markedly inhibited the TNF alpha-induced one. Nitrites 86-93 interferon gamma Homo sapiens 40-49 8443182-0 1993 Alignment of disulfide bonds of the extracellular domain of the interferon gamma receptor and investigation of their role in biological activity. Disulfides 13-22 interferon gamma Homo sapiens 64-80 8440379-1 1993 Pteridines are heterocyclic compounds which are synthesized and released by human monocytes/macrophages following stimulation by interferon-gamma. Pteridines 0-10 interferon gamma Homo sapiens 129-145 8443182-1 1993 The extracellular ligand binding domain of the human interferon gamma receptor includes eight cysteine residues forming four disulfide bonds. Cysteine 94-102 interferon gamma Homo sapiens 53-69 8443182-1 1993 The extracellular ligand binding domain of the human interferon gamma receptor includes eight cysteine residues forming four disulfide bonds. Disulfides 125-134 interferon gamma Homo sapiens 53-69 8443182-3 1993 We investigated the alignment of the disulfide bonds, using an enzymatically deglycosylated form of a soluble interferon gamma receptor, produced in baculovirus-infected insect cells. Disulfides 37-46 interferon gamma Homo sapiens 110-126 8440344-3 1993 Highly purified and IFN-gamma-activated monocytes were cytolytic to U937 cells up to 81.9 +/- 5.3% (mean +/- SEM) in a 24-hour MTT cytotoxicity assay at an effector-to-target-cell ratio of 10. monooxyethylene trimethylolpropane tristearate 127-130 interferon gamma Homo sapiens 20-29 8324934-5 1993 The antiproliferative effect of minocycline in cloned synovial T-cells is demonstrated; moreover IFN-gamma production in cloned synovial T-cells is inhibited by minocycline. Minocycline 161-172 interferon gamma Homo sapiens 97-106 7680613-2 1993 SEB-activated lamina propria T cells produced interleukin-2 and interferon-gamma and T cell activation was accompanied by tissue damage, which was inhibited by FK506. Tacrolimus 160-165 interferon gamma Homo sapiens 64-80 8490055-4 1993 In addition, we found significant correlations between neopterin and interferon-gamma (rs = 0.417, p < 0.05), and between neopterin and soluble CD8 concentrations (rs = 0.430, p < 0.05). Neopterin 55-64 interferon gamma Homo sapiens 69-85 8490055-9 1993 Endogenous interferon-gamma, which is derived from activated T-cells, may induce neopterin release by monocytes/macrophages. Neopterin 81-90 interferon gamma Homo sapiens 11-27 8384636-7 1993 In contrast, the supplementation of L-tryptophan to the culture medium completely abolished the IFN gamma effect. Tryptophan 36-48 interferon gamma Homo sapiens 96-105 8450066-7 1993 In particular, IL-1 beta and neopterin production were further enhanced by stimulation with either interferon-gamma (IFN-gamma) or TNF-alpha without a synergistic effect. Neopterin 29-38 interferon gamma Homo sapiens 99-115 8450066-7 1993 In particular, IL-1 beta and neopterin production were further enhanced by stimulation with either interferon-gamma (IFN-gamma) or TNF-alpha without a synergistic effect. Neopterin 29-38 interferon gamma Homo sapiens 117-126 8450071-2 1993 We have investigated the regulation of key human iron binding proteins in mononuclear phagocytes by IFN gamma and iron transferrin. Iron 49-53 interferon gamma Homo sapiens 100-109 8450071-3 1993 In a previous study, we demonstrated that IFN gamma downregulates the expression on human monocytes of transferrin receptors, the major source of iron for the cell. Iron 146-150 interferon gamma Homo sapiens 42-51 8450071-4 1993 In the present study, we show that IFN gamma also downregulates the intracellular concentration of ferritin, the major iron storage protein in the cell. Iron 119-123 interferon gamma Homo sapiens 35-44 8450071-6 1993 Consistent with its downregulating effect on these iron proteins, IFN gamma treatment also results in decreased iron incorporation. Iron 51-55 interferon gamma Homo sapiens 66-75 8450071-6 1993 Consistent with its downregulating effect on these iron proteins, IFN gamma treatment also results in decreased iron incorporation. Iron 112-116 interferon gamma Homo sapiens 66-75 8450071-7 1993 IFN gamma-activated monocytes incorporated 33% less iron from 59Fe-transferrin than nonactivated monocytes (P < 0.05, t test). Iron 52-56 interferon gamma Homo sapiens 0-9 8450071-8 1993 Gel filtration chromatography revealed that incorporated iron is located primarily in ferritin in both nonactivated and IFN gamma-activated monocytes. Iron 57-61 interferon gamma Homo sapiens 120-129 8450071-11 1993 We have found that iron transferrin markedly upregulates both transferrin receptor expression and intracellular ferritin content in both nonactivated (2.3- and 1.3-fold, respectively) and IFN gamma-activated (3.4- and 2.9-fold, respectively) monocytes. Iron 19-23 interferon gamma Homo sapiens 188-197 7680061-8 1993 Furthermore, in addition to antibody blocking of cell adhesion molecules, anti-IFN-gamma antibody therapy or pharmacologic manipulation of endothelial cell receptor expression may reduce PRBC sequestration and ameliorate the events associated with human cerebral malaria. prbc 187-191 interferon gamma Homo sapiens 79-88 8384238-3 1993 Following pretreatment of human PMNs with recombinant IFN-gamma, superoxide anion release was selectively primed toward the receptor-initiated stimulants f-Met-Leu-Phe (fMLP) and C5a but not toward the transduction-mediated stimulants phorbol myristate acetate and A23187, a calcium ionophore. Superoxides 65-81 interferon gamma Homo sapiens 54-63 8384238-3 1993 Following pretreatment of human PMNs with recombinant IFN-gamma, superoxide anion release was selectively primed toward the receptor-initiated stimulants f-Met-Leu-Phe (fMLP) and C5a but not toward the transduction-mediated stimulants phorbol myristate acetate and A23187, a calcium ionophore. N-Formylmethionine Leucyl-Phenylalanine 154-167 interferon gamma Homo sapiens 54-63 8384636-8 1993 We therefore conclude that the induction of L-tryptophan degradation in 86HG39 cells by IFN gamma, possibly by activation of the indoleamine-2,3-dioxygenase, is responsible for the IFN gamma induced toxoplasmostasis within the glioblastoma cell line. Tryptophan 44-56 interferon gamma Homo sapiens 88-97 8384238-3 1993 Following pretreatment of human PMNs with recombinant IFN-gamma, superoxide anion release was selectively primed toward the receptor-initiated stimulants f-Met-Leu-Phe (fMLP) and C5a but not toward the transduction-mediated stimulants phorbol myristate acetate and A23187, a calcium ionophore. Tetradecanoylphorbol Acetate 235-260 interferon gamma Homo sapiens 54-63 8384238-3 1993 Following pretreatment of human PMNs with recombinant IFN-gamma, superoxide anion release was selectively primed toward the receptor-initiated stimulants f-Met-Leu-Phe (fMLP) and C5a but not toward the transduction-mediated stimulants phorbol myristate acetate and A23187, a calcium ionophore. Calcimycin 265-271 interferon gamma Homo sapiens 54-63 8384636-8 1993 We therefore conclude that the induction of L-tryptophan degradation in 86HG39 cells by IFN gamma, possibly by activation of the indoleamine-2,3-dioxygenase, is responsible for the IFN gamma induced toxoplasmostasis within the glioblastoma cell line. Tryptophan 44-56 interferon gamma Homo sapiens 181-190 8384238-3 1993 Following pretreatment of human PMNs with recombinant IFN-gamma, superoxide anion release was selectively primed toward the receptor-initiated stimulants f-Met-Leu-Phe (fMLP) and C5a but not toward the transduction-mediated stimulants phorbol myristate acetate and A23187, a calcium ionophore. Calcium 275-282 interferon gamma Homo sapiens 54-63 8384238-4 1993 IFN-gamma also induced priming toward the stimulant NaF, a direct activator of guanine nucleotide regulatory proteins. Guanine Nucleotides 79-97 interferon gamma Homo sapiens 0-9 8388062-5 1993 dbcAMP suppressed the IFN-gamma-induced Fc gamma R III expression on peripheral eosinophils. Bucladesine 0-6 interferon gamma Homo sapiens 22-31 7680098-8 1993 Furthermore, the tyrosine phosphatase inhibitors phenylarsine oxide and zinc chloride also inhibited GAF formation in vitro, but only if these agents were added to cell homogenates before IFN-gamma was added. oxophenylarsine 49-67 interferon gamma Homo sapiens 188-197 7680098-8 1993 Furthermore, the tyrosine phosphatase inhibitors phenylarsine oxide and zinc chloride also inhibited GAF formation in vitro, but only if these agents were added to cell homogenates before IFN-gamma was added. zinc chloride 72-85 interferon gamma Homo sapiens 188-197 8455639-7 1993 Cycloheximide treatment abolished the IFN-gamma induced increase in pIgR mRNA, indicating that induction of pIgR mRNA by IFN-gamma requires de novo protein synthesis. Cycloheximide 0-13 interferon gamma Homo sapiens 38-47 8455639-7 1993 Cycloheximide treatment abolished the IFN-gamma induced increase in pIgR mRNA, indicating that induction of pIgR mRNA by IFN-gamma requires de novo protein synthesis. Cycloheximide 0-13 interferon gamma Homo sapiens 121-130 7679423-6 1993 Genistein not only abrogated the IFN-gamma-induced enhancement of tyrosine phosphorylation, but also inhibited the IFN-gamma-induced production of inositol-4-5-triphosphate and the elevation of intracellular calcium. Tyrosine 66-74 interferon gamma Homo sapiens 33-42 8383325-2 1993 In this report we demonstrate that the cytokine combination of human recombinant interleukin 1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) induces the formation of nitric oxide by human islets. Nitric Oxide 212-224 interferon gamma Homo sapiens 158-185 8383325-5 1993 IL-1 beta and IFN-gamma are sufficient to induce nitric oxide formation by human islets, whereas TNF-alpha potentiates nitrite production. Nitric Oxide 49-61 interferon gamma Homo sapiens 14-23 8383325-8 1993 Higher concentrations (IL-1 beta at 75 units/ml, 3.5 nM TNF-alpha, and IFN-gamma at 750 units/ml) inhibit insulin secretion from human islets, and the inhibitory effect is prevented by NG-monomethyl-L-arginine. omega-N-Methylarginine 185-209 interferon gamma Homo sapiens 71-80 8094032-3 1993 Incubation of the human glioma cell line HS 683 and the neuroblastoma cell line SK-N-SH with 12-phorbol 13-myristic acid (PMA), retinoic acid, or gamma-interferon (IFN-gamma) strongly stimulates ICAM-1 expression. 12-phorbol 13-myristic acid 93-120 interferon gamma Homo sapiens 164-173 8094032-10 1993 These results suggest that although PMA-induced ICAM-1 expression is PKC dependent on HS 683 and SK-N-SH cells, the stimulation of ICAM-1 expression by retinoic acid and by IFN-gamma may be due to PKC inactivation at longer time points (24 h), as mimicked by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, staurosporine, or PKC depletion by high doses of PMA. Tetradecanoylphorbol Acetate 36-39 interferon gamma Homo sapiens 173-182 8094032-10 1993 These results suggest that although PMA-induced ICAM-1 expression is PKC dependent on HS 683 and SK-N-SH cells, the stimulation of ICAM-1 expression by retinoic acid and by IFN-gamma may be due to PKC inactivation at longer time points (24 h), as mimicked by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, staurosporine, or PKC depletion by high doses of PMA. H-7 dihydrochloride 259-320 interferon gamma Homo sapiens 173-182 8094032-10 1993 These results suggest that although PMA-induced ICAM-1 expression is PKC dependent on HS 683 and SK-N-SH cells, the stimulation of ICAM-1 expression by retinoic acid and by IFN-gamma may be due to PKC inactivation at longer time points (24 h), as mimicked by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, staurosporine, or PKC depletion by high doses of PMA. Staurosporine 322-335 interferon gamma Homo sapiens 173-182 7679423-0 1993 Inhibition of tyrosine phosphorylation prevents IFN-gamma-induced HLA-DR molecule expression. Tyrosine 14-22 interferon gamma Homo sapiens 48-57 7679423-1 1993 We have previously demonstrated that HLA-DR molecule expression induced by IFN-gamma is associated with phosphatidylinositide turnover, activation of protein kinase C, and elevation of intracellular calcium. phosphatidylinositide 104-125 interferon gamma Homo sapiens 75-84 7679423-6 1993 Genistein not only abrogated the IFN-gamma-induced enhancement of tyrosine phosphorylation, but also inhibited the IFN-gamma-induced production of inositol-4-5-triphosphate and the elevation of intracellular calcium. inositol-4-5-triphosphate 147-172 interferon gamma Homo sapiens 115-124 7679423-1 1993 We have previously demonstrated that HLA-DR molecule expression induced by IFN-gamma is associated with phosphatidylinositide turnover, activation of protein kinase C, and elevation of intracellular calcium. Calcium 199-206 interferon gamma Homo sapiens 75-84 7679423-5 1993 Being consistent with this, immunoblotting with an anti-phosphotyrosine mAb revealed that IFN-gamma induces a rapid increase in protein tyrosine phosphorylation. Phosphotyrosine 56-71 interferon gamma Homo sapiens 90-99 7679423-6 1993 Genistein not only abrogated the IFN-gamma-induced enhancement of tyrosine phosphorylation, but also inhibited the IFN-gamma-induced production of inositol-4-5-triphosphate and the elevation of intracellular calcium. Calcium 208-215 interferon gamma Homo sapiens 33-42 7679423-5 1993 Being consistent with this, immunoblotting with an anti-phosphotyrosine mAb revealed that IFN-gamma induces a rapid increase in protein tyrosine phosphorylation. Tyrosine 63-71 interferon gamma Homo sapiens 90-99 7679423-6 1993 Genistein not only abrogated the IFN-gamma-induced enhancement of tyrosine phosphorylation, but also inhibited the IFN-gamma-induced production of inositol-4-5-triphosphate and the elevation of intracellular calcium. Genistein 0-9 interferon gamma Homo sapiens 33-42 7679423-6 1993 Genistein not only abrogated the IFN-gamma-induced enhancement of tyrosine phosphorylation, but also inhibited the IFN-gamma-induced production of inositol-4-5-triphosphate and the elevation of intracellular calcium. Calcium 208-215 interferon gamma Homo sapiens 115-124 7679423-6 1993 Genistein not only abrogated the IFN-gamma-induced enhancement of tyrosine phosphorylation, but also inhibited the IFN-gamma-induced production of inositol-4-5-triphosphate and the elevation of intracellular calcium. Genistein 0-9 interferon gamma Homo sapiens 115-124 7679423-8 1993 These findings suggest that the tyrosine phosphorylation is an early and critical event that precedes phosphatidylinositide turnover leading to activation of protein kinase C and elevation of intracellular calcium concentration during IFN-gamma-inducible DR molecule expression. Tyrosine 32-40 interferon gamma Homo sapiens 235-244 7679423-8 1993 These findings suggest that the tyrosine phosphorylation is an early and critical event that precedes phosphatidylinositide turnover leading to activation of protein kinase C and elevation of intracellular calcium concentration during IFN-gamma-inducible DR molecule expression. phosphatidylinositide 102-123 interferon gamma Homo sapiens 235-244 7679423-8 1993 These findings suggest that the tyrosine phosphorylation is an early and critical event that precedes phosphatidylinositide turnover leading to activation of protein kinase C and elevation of intracellular calcium concentration during IFN-gamma-inducible DR molecule expression. Calcium 206-213 interferon gamma Homo sapiens 235-244 8430950-3 1993 The secretion of TNF alpha and IFN gamma was determined in intact (unstimulated) and phytohemagglutinin/phorbol myristate acetate (PHA + PMA)-stimulated BAL leukocyte cultures and compared with that in control cultures. Tetradecanoylphorbol Acetate 104-129 interferon gamma Homo sapiens 31-40 8438880-2 1993 Recent studies have shown that certain lymphokines such as tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) can significantly enhance O2- production by phagocytic cells. Superoxides 158-160 interferon gamma Homo sapiens 103-119 8438880-2 1993 Recent studies have shown that certain lymphokines such as tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) can significantly enhance O2- production by phagocytic cells. Superoxides 158-160 interferon gamma Homo sapiens 121-130 8430950-4 1993 In all patients studied, the background and PHA + PMA-induced secretion of TNF alpha and IFN gamma was significantly (p < 0.001) higher than that in parallel control cultures. Tetradecanoylphorbol Acetate 50-53 interferon gamma Homo sapiens 89-98 8425194-9 1993 The results provide further evidence for including a biological response modifier, such as IFN-gamma, which can increase the expression of specific tumor antigens (i.e., TAG-72 and CEA) subsequently leading to a dramatic improvement in the antitumor efficacy of a radionuclide-conjugated MAb. Radioisotopes 264-276 interferon gamma Homo sapiens 91-100 8425199-6 1993 IL-1 caused a time- and dose-dependent increase in 125I-labeled IFN-gamma binding that was maximal at 6 h, persisted for at least 24 h, and was blocked by both actinomycin D and cycloheximide. Dactinomycin 160-173 interferon gamma Homo sapiens 64-73 8425199-6 1993 IL-1 caused a time- and dose-dependent increase in 125I-labeled IFN-gamma binding that was maximal at 6 h, persisted for at least 24 h, and was blocked by both actinomycin D and cycloheximide. Cycloheximide 178-191 interferon gamma Homo sapiens 64-73 8425199-8 1993 IL-1 also produced a time- and dose-dependent increase in IFN-gamma receptor mRNA levels that was maximal at 3 h and persisted for at least 24 h. Actinomycin D, but not cycloheximide, completely blocked the IL-1-mediated increase in IFN-gamma receptor mRNA levels. Dactinomycin 146-159 interferon gamma Homo sapiens 58-67 8428396-7 1993 For other agonists and cytokines the increases in permeability were: (i) histamine (50-400 pmol/ml) increased uptake 5-22%; (ii) TNF (12.5-100 ng/ml) increased uptake 2-12%; (iii) IFN-gamma (125-250 U/ml) increased uptake 1.5-3%. Histamine 73-82 interferon gamma Homo sapiens 180-189 8425199-8 1993 IL-1 also produced a time- and dose-dependent increase in IFN-gamma receptor mRNA levels that was maximal at 3 h and persisted for at least 24 h. Actinomycin D, but not cycloheximide, completely blocked the IL-1-mediated increase in IFN-gamma receptor mRNA levels. Dactinomycin 146-159 interferon gamma Homo sapiens 233-242 8389732-1 1993 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) inhibits the proliferation of mitogen-stimulated human mononuclear cells (MNC) as well as the production of a number of proinflammatory cytokines, including interleukin (IL)-1 alpha, IL-6, tumour necrosis factor-alpha, IL-2, interferon-gamma (IFNg) and lymphotoxin (LT). 1,25-dihydroxyvitamin d3 (1,25-(oh)2d3 0-38 interferon gamma Homo sapiens 265-281 8389732-1 1993 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) inhibits the proliferation of mitogen-stimulated human mononuclear cells (MNC) as well as the production of a number of proinflammatory cytokines, including interleukin (IL)-1 alpha, IL-6, tumour necrosis factor-alpha, IL-2, interferon-gamma (IFNg) and lymphotoxin (LT). 1,25-dihydroxyvitamin d3 (1,25-(oh)2d3 0-38 interferon gamma Homo sapiens 283-287 8473417-5 1993 Both HLA-DR expression and inhibition of proliferation were found to be directly dependent on the dose of IFN-gamma that was allowed to diffuse in the agarose beneath the spheroids. Sepharose 151-158 interferon gamma Homo sapiens 106-115 8473009-2 1993 The spontaneous release of reactive oxygen radicals and intermediates (ROI) increases five- to eightfold after treatment of monocytes with the lymphokine interferon-gamma (IFN-gamma). reactive oxygen radicals 27-51 interferon gamma Homo sapiens 172-181 8473009-5 1993 Second, the mechanism of inactivation was dependent on the enhanced spontaneous release of ROI by IFN-gamma-activated mononuclear phagocytes, since either the enzyme catalase or the free radical scavenger butylated hydroxyanisole (BHA) could block this activity. Butylated Hydroxyanisole 205-229 interferon gamma Homo sapiens 98-107 8423347-7 1993 T cell lines generated against Tct proliferated in response to parasite lysate only in the presence of autologous APC and produced IL-2, IL-6, and IFN-gamma but not IL-4 in response to PMA plus ionomycin. Tetradecanoylphorbol Acetate 185-188 interferon gamma Homo sapiens 147-156 8473009-5 1993 Second, the mechanism of inactivation was dependent on the enhanced spontaneous release of ROI by IFN-gamma-activated mononuclear phagocytes, since either the enzyme catalase or the free radical scavenger butylated hydroxyanisole (BHA) could block this activity. Butylated Hydroxyanisole 231-234 interferon gamma Homo sapiens 98-107 8509149-5 1993 Monolayers of cells were incubated with cytokines in different concentrations for 24 and 48 h. IFN-gamma inhibits the HUVEC [3H]thymidine uptake in a dose-dependent manner. Tritium 125-127 interferon gamma Homo sapiens 95-104 8509149-5 1993 Monolayers of cells were incubated with cytokines in different concentrations for 24 and 48 h. IFN-gamma inhibits the HUVEC [3H]thymidine uptake in a dose-dependent manner. Thymidine 128-137 interferon gamma Homo sapiens 95-104 8423347-7 1993 T cell lines generated against Tct proliferated in response to parasite lysate only in the presence of autologous APC and produced IL-2, IL-6, and IFN-gamma but not IL-4 in response to PMA plus ionomycin. Ionomycin 194-203 interferon gamma Homo sapiens 147-156 8386114-7 1993 Our results suggest that TNF-alpha and IFN-gamma may be involved in the regulation of HFA growth and differentiation via local IGF-II production. hfa 86-89 interferon gamma Homo sapiens 39-48 8454908-0 1993 Role of serotonin in the regulation of interferon-gamma production by human natural killer cells. Serotonin 8-17 interferon gamma Homo sapiens 39-55 8454908-3 1993 Monocyte-induced inhibition of IFN-gamma production was abrogated by the biogenic amine serotonin, acting via the 5-hydroxytryptamine, or serotonin (5-HT1A), subset of serotonin receptors (5-HTR). Amines 82-87 interferon gamma Homo sapiens 31-40 8454908-3 1993 Monocyte-induced inhibition of IFN-gamma production was abrogated by the biogenic amine serotonin, acting via the 5-hydroxytryptamine, or serotonin (5-HT1A), subset of serotonin receptors (5-HTR). Serotonin 88-97 interferon gamma Homo sapiens 31-40 8454908-3 1993 Monocyte-induced inhibition of IFN-gamma production was abrogated by the biogenic amine serotonin, acting via the 5-hydroxytryptamine, or serotonin (5-HT1A), subset of serotonin receptors (5-HTR). Serotonin 114-133 interferon gamma Homo sapiens 31-40 8454908-3 1993 Monocyte-induced inhibition of IFN-gamma production was abrogated by the biogenic amine serotonin, acting via the 5-hydroxytryptamine, or serotonin (5-HT1A), subset of serotonin receptors (5-HTR). Serotonin 138-147 interferon gamma Homo sapiens 31-40 8454908-4 1993 Thereby, serotonin effectively promoted IFN-gamma production in the presence of monocytes. Serotonin 9-18 interferon gamma Homo sapiens 40-49 8492414-5 1993 CS seems to inhibit the production of cytokines such as IL-2 and IFN-gamma, and it damages the activated suppressor/cytotoxic T cells. Cyclosporine 0-2 interferon gamma Homo sapiens 65-74 8434236-5 1993 Inhibition with 5,6-dichloro-1-beta-ribofuranosyl-benzimidazole (DRB) indicated a half-life for IFN-gamma-induced SC mRNA of approximately 1 h. Cycloheximide (CHX) abolished the IFN-gamma-induced accumulation of SC mRNA in a reversible manner; the time-course suggested that de novo synthesis of protein factor(s) with a turnover time shorter than 6 h was required for accumulation of SC message. Dichlororibofuranosylbenzimidazole 16-63 interferon gamma Homo sapiens 96-105 8381917-4 1993 Aglycosylated IgG3 was, however, much less effective in triggering superoxide generation by interferon gamma treated U937 cells at low sensitization levels as threshold responses required only 60 glycosylated IgG3 molecules per erythrocyte compared with 16,000 aglycosylated molecules. Superoxides 67-77 interferon gamma Homo sapiens 92-108 8434236-5 1993 Inhibition with 5,6-dichloro-1-beta-ribofuranosyl-benzimidazole (DRB) indicated a half-life for IFN-gamma-induced SC mRNA of approximately 1 h. Cycloheximide (CHX) abolished the IFN-gamma-induced accumulation of SC mRNA in a reversible manner; the time-course suggested that de novo synthesis of protein factor(s) with a turnover time shorter than 6 h was required for accumulation of SC message. Dichlororibofuranosylbenzimidazole 16-63 interferon gamma Homo sapiens 178-187 8434236-5 1993 Inhibition with 5,6-dichloro-1-beta-ribofuranosyl-benzimidazole (DRB) indicated a half-life for IFN-gamma-induced SC mRNA of approximately 1 h. Cycloheximide (CHX) abolished the IFN-gamma-induced accumulation of SC mRNA in a reversible manner; the time-course suggested that de novo synthesis of protein factor(s) with a turnover time shorter than 6 h was required for accumulation of SC message. Dichlororibofuranosylbenzimidazole 65-68 interferon gamma Homo sapiens 96-105 8434236-5 1993 Inhibition with 5,6-dichloro-1-beta-ribofuranosyl-benzimidazole (DRB) indicated a half-life for IFN-gamma-induced SC mRNA of approximately 1 h. Cycloheximide (CHX) abolished the IFN-gamma-induced accumulation of SC mRNA in a reversible manner; the time-course suggested that de novo synthesis of protein factor(s) with a turnover time shorter than 6 h was required for accumulation of SC message. Dichlororibofuranosylbenzimidazole 65-68 interferon gamma Homo sapiens 178-187 8434236-5 1993 Inhibition with 5,6-dichloro-1-beta-ribofuranosyl-benzimidazole (DRB) indicated a half-life for IFN-gamma-induced SC mRNA of approximately 1 h. Cycloheximide (CHX) abolished the IFN-gamma-induced accumulation of SC mRNA in a reversible manner; the time-course suggested that de novo synthesis of protein factor(s) with a turnover time shorter than 6 h was required for accumulation of SC message. Cycloheximide 144-157 interferon gamma Homo sapiens 96-105 8381283-0 1993 Studies on the regulatory mechanisms of interleukin-8 gene expression in resting and IFN-gamma-treated neutrophils: evidence on the capability of staurosporine of inducing the production of interleukin-8 by human neutrophils. Staurosporine 146-159 interferon gamma Homo sapiens 85-94 8434236-5 1993 Inhibition with 5,6-dichloro-1-beta-ribofuranosyl-benzimidazole (DRB) indicated a half-life for IFN-gamma-induced SC mRNA of approximately 1 h. Cycloheximide (CHX) abolished the IFN-gamma-induced accumulation of SC mRNA in a reversible manner; the time-course suggested that de novo synthesis of protein factor(s) with a turnover time shorter than 6 h was required for accumulation of SC message. Cycloheximide 159-162 interferon gamma Homo sapiens 96-105 8416207-3 1993 In Wish and HEL cells, co-treatment with cycloheximide was required for IFN-gamma to increase the level of RB mRNA. Cycloheximide 41-54 interferon gamma Homo sapiens 72-81 8416207-4 1993 Pre-treatment of THP-1 cells with cycloheximide prior to IFN-gamma treatment augmented the effects of IFN-gamma on RB gene expression. Cycloheximide 34-47 interferon gamma Homo sapiens 102-111 8427819-3 1993 After addition of mercuric chloride, a statistically significant increase of IFN-gamma was seen in the patient group, indicating a higher reactivity to this metal salt. Mercuric Chloride 18-35 interferon gamma Homo sapiens 77-86 7678411-8 1993 However, interferon-gamma alone or in combination with tumor necrosis factor-alpha significantly increased intracellular cGMP formation in intact HUVEC by 50 and 80%, respectively. Cyclic GMP 121-125 interferon gamma Homo sapiens 9-25 8427819-3 1993 After addition of mercuric chloride, a statistically significant increase of IFN-gamma was seen in the patient group, indicating a higher reactivity to this metal salt. metal salt 157-167 interferon gamma Homo sapiens 77-86 8339382-1 1993 The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics. doxifluridine 214-238 interferon gamma Homo sapiens 128-144 8339382-1 1993 The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics. doxifluridine 214-238 interferon gamma Homo sapiens 146-155 8439987-4 1993 Generally, arabinogalactan pretreatment induced an increased release of interferon gamma (IFN gamma), tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta) and IL-6 but only IFN gamma was involved in enhancement of NK cytotoxicity since cytotoxicity enhancement of PBMC and PNAC but not that of monocytes could be blocked when anti-IFN gamma antibodies were present during pretreatment. arabinogalactan 11-26 interferon gamma Homo sapiens 90-99 8339382-1 1993 The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics. doxifluridine 240-248 interferon gamma Homo sapiens 128-144 8439987-4 1993 Generally, arabinogalactan pretreatment induced an increased release of interferon gamma (IFN gamma), tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta) and IL-6 but only IFN gamma was involved in enhancement of NK cytotoxicity since cytotoxicity enhancement of PBMC and PNAC but not that of monocytes could be blocked when anti-IFN gamma antibodies were present during pretreatment. arabinogalactan 11-26 interferon gamma Homo sapiens 180-189 8339382-1 1993 The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics. doxifluridine 240-248 interferon gamma Homo sapiens 146-155 8439987-4 1993 Generally, arabinogalactan pretreatment induced an increased release of interferon gamma (IFN gamma), tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta) and IL-6 but only IFN gamma was involved in enhancement of NK cytotoxicity since cytotoxicity enhancement of PBMC and PNAC but not that of monocytes could be blocked when anti-IFN gamma antibodies were present during pretreatment. arabinogalactan 11-26 interferon gamma Homo sapiens 180-189 8339382-1 1993 The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics. Fluorouracil 258-272 interferon gamma Homo sapiens 128-144 8339382-1 1993 The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics. Fluorouracil 258-272 interferon gamma Homo sapiens 146-155 8339382-1 1993 The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics. Fluorouracil 274-280 interferon gamma Homo sapiens 128-144 8339382-1 1993 The present study shows that various cytokines such as tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1 alpha), and interferon-gamma (IFN gamma) make tumor cells much more susceptible to the cytostatic 5"-deoxy-5-fluorouridine (5"-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostatics. Fluorouracil 274-280 interferon gamma Homo sapiens 146-155 8419080-3 1993 Interferon-gamma (IFN-gamma), bacteria, and bacterial products modulated expression of some of the surface markers, induced and/or enhanced respiratory burst, phagocytic activity, secretion of tumour necrosis factor, and tumouricidal activity; in contrast, these cells were not able to generate reactive nitrogen intermediates. Nitrogen 304-312 interferon gamma Homo sapiens 0-16 8425226-8 1993 IL-1 beta, IL-2, and IFN-gamma, was also elevated in cDT-stimulated cultures; and (4) the enhanced proliferative response to cDT could be attributed to CD4+ helper T cells. cdt 53-56 interferon gamma Homo sapiens 21-30 8419080-3 1993 Interferon-gamma (IFN-gamma), bacteria, and bacterial products modulated expression of some of the surface markers, induced and/or enhanced respiratory burst, phagocytic activity, secretion of tumour necrosis factor, and tumouricidal activity; in contrast, these cells were not able to generate reactive nitrogen intermediates. Nitrogen 304-312 interferon gamma Homo sapiens 18-27 22358680-0 1993 Interferon-gamma-induced differentiation of human neuroblastoma cells increases cellular uptake and halflife of metaiodobenzylguanidine. 3-Iodobenzylguanidine 112-135 interferon gamma Homo sapiens 0-16 8453258-4 1993 Biochemical changes, the formation of neopterin, the degradation of tryptophan are closely related to interferon-gamma activity. Neopterin 38-47 interferon gamma Homo sapiens 102-118 8453258-4 1993 Biochemical changes, the formation of neopterin, the degradation of tryptophan are closely related to interferon-gamma activity. Tryptophan 68-78 interferon gamma Homo sapiens 102-118 7763744-0 1993 Interferon-gamma-induced differentiation of human neuroblastoma cells increases cellular uptake and halflife of metaiodobenzylguanidine. 3-Iodobenzylguanidine 112-135 interferon gamma Homo sapiens 0-16 8419187-4 1993 After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells. Tetradecanoylphorbol Acetate 23-54 interferon gamma Homo sapiens 243-259 8419187-4 1993 After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells. Tetradecanoylphorbol Acetate 23-54 interferon gamma Homo sapiens 261-270 8419187-4 1993 After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells. Tetradecanoylphorbol Acetate 56-59 interferon gamma Homo sapiens 243-259 8419187-4 1993 After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells. Tetradecanoylphorbol Acetate 56-59 interferon gamma Homo sapiens 261-270 8419187-4 1993 After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells. Calcium 65-72 interferon gamma Homo sapiens 243-259 8419187-4 1993 After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells. Calcium 65-72 interferon gamma Homo sapiens 261-270 8419187-4 1993 After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells. Calcimycin 83-89 interferon gamma Homo sapiens 243-259 8419187-4 1993 After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells. Calcimycin 83-89 interferon gamma Homo sapiens 261-270 8324385-11 1993 Whereas the secretion of interferon-gamma was completely suppressed by suramin, interleukin-2 (IL-2) and IL-4 production was stimulated. Suramin 71-78 interferon gamma Homo sapiens 25-41 8167696-3 1993 We report here that MDM treated with IFN-gamma developed an increase in their capacity to ingest and kill unopsonized C. albicans and to release O2- upon stimulation with candida. Oxygen 145-147 interferon gamma Homo sapiens 37-46 8167697-0 1993 Is the IFN-gamma-induced enhancement of superoxide production in CGD-phagocytes caused by increased expression of the p47-phox cytosolic protein. Superoxides 40-50 interferon gamma Homo sapiens 7-16 8499767-1 1993 Large amounts of neopterin are produced and released from human macrophages on stimulation with interferon-gamma. Neopterin 17-26 interferon gamma Homo sapiens 96-112 8167697-1 1993 Interferon-gamma (IFN-gamma) had been shown to increase superoxide production of cultured monocytes from patients with chronic granulomatous disease (CGD). Superoxides 56-66 interferon gamma Homo sapiens 0-16 8167697-1 1993 Interferon-gamma (IFN-gamma) had been shown to increase superoxide production of cultured monocytes from patients with chronic granulomatous disease (CGD). Superoxides 56-66 interferon gamma Homo sapiens 18-27 8167697-2 1993 To elucidate the mechanism of the IFN-gamma-induced improvement of superoxide production of cultured monocytes from patients with CGD we examined the influence of IFN-gamma on the expression and the activity of the NADPH-oxidase in the monocytic cell-line Mono Mac 6. Superoxides 67-77 interferon gamma Homo sapiens 34-43 8167697-3 1993 After cultivation of Mono Mac 6-cells in the presence of 500 U/ml IFN-gamma the superoxide production was found to be increased as well as the expression of the p47-phox cytosolic protein of the phagocytic NADPH-oxidase. Superoxides 80-90 interferon gamma Homo sapiens 66-75 11578320-0 1993 Interaction of interferon gamma and CPT-11, a new derivative of camptothecin, in human endometrial carcinoma cell lines. Camptothecin 64-76 interferon gamma Homo sapiens 15-42 8443122-1 1993 Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA). phorbol myristic acetate 128-152 interferon gamma Homo sapiens 51-67 8443122-1 1993 Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA). Tetradecanoylphorbol Acetate 154-157 interferon gamma Homo sapiens 51-67 11578320-4 1993 In both cell lines, IFN-gamma at clinically achievable concentrations (10 and 100 U ml-1 enhanced the anti-proliferative activity of CPT-11 in the range of concentrations where CPT-11 showed more than 10% cell growth inhibition. Irinotecan 133-139 interferon gamma Homo sapiens 20-29 8443122-1 1993 Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA). Cyclosporine 245-258 interferon gamma Homo sapiens 51-67 8443122-1 1993 Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA). Cyclosporine 260-263 interferon gamma Homo sapiens 51-67 11578320-4 1993 In both cell lines, IFN-gamma at clinically achievable concentrations (10 and 100 U ml-1 enhanced the anti-proliferative activity of CPT-11 in the range of concentrations where CPT-11 showed more than 10% cell growth inhibition. Irinotecan 177-183 interferon gamma Homo sapiens 20-29 8445046-2 1993 While acute ethanol treatment did not induce TNF alpha in M phi, it was a potent down-regulator of M phi TNF alpha production whether induced by the combination of interferon-gamma plus muramyl dipeptide (MDP) (P < 0.001), lipopolysaccharide (LPS) alone (P < 0.01), or interferon-gamma plus LPS. Ethanol 12-19 interferon gamma Homo sapiens 164-180 8445052-5 1993 The TGIF activity detected in CSN of OK-MC was further characterized as derived from a cytokine different from interferon gamma (IFN gamma), tumor necrosis factor (TNF), or lymphotoxin (LT) by a neutralization test using monoclonal antibodies to these cytokines. ok-mc 37-42 interferon gamma Homo sapiens 111-138 8127073-1 1993 Incubation of primary skin fibroblast cultures with the cytokines interferon-gamma and tumour necrosis factor-alpha stimulates the de novo pathway of tetrahydrobiopterin biosynthesis. sapropterin 150-169 interferon gamma Homo sapiens 66-115 8445046-2 1993 While acute ethanol treatment did not induce TNF alpha in M phi, it was a potent down-regulator of M phi TNF alpha production whether induced by the combination of interferon-gamma plus muramyl dipeptide (MDP) (P < 0.001), lipopolysaccharide (LPS) alone (P < 0.01), or interferon-gamma plus LPS. Ethanol 12-19 interferon gamma Homo sapiens 275-291 8396466-0 1993 Phorbol myristate acetate-differentiated THP-1 cells display increased levels of MHC class I and class II mRNA and interferon-gamma-inducible tumoricidal activity. Tetradecanoylphorbol Acetate 0-25 interferon gamma Homo sapiens 115-131 8159911-2 1993 Measurement of urine neopterin, product of a metabolic pathway controlled by interferon-gamma, has been found useful in many clinical conditions. Neopterin 21-30 interferon gamma Homo sapiens 77-93 7908588-4 1993 Preincubation with PT or CT for 24 h also inhibited IFN-gamma induced inositol 1-monophosphate (Ins 1-P), inositol 1,4 bisphosphate (Ins 1,4-P2) and inositol 1,4,5 trisphosphate (Ins 1,4,5-P3) formation. ins 1,4-p2 133-143 interferon gamma Homo sapiens 52-61 7908588-0 1993 Effects of pertussis and cholera toxin on the interferon-gamma stimulated immunocytochemical staining of ICAM-1 and inositol phosphate formation in a human renal carcinoma cell line. Inositol Phosphates 116-134 interferon gamma Homo sapiens 46-62 7908588-4 1993 Preincubation with PT or CT for 24 h also inhibited IFN-gamma induced inositol 1-monophosphate (Ins 1-P), inositol 1,4 bisphosphate (Ins 1,4-P2) and inositol 1,4,5 trisphosphate (Ins 1,4,5-P3) formation. Inositol 1,4,5-Trisphosphate 149-177 interferon gamma Homo sapiens 52-61 7908588-1 1993 We have recently shown that interferon-gamma (IFN-gamma) stimulated immunocytochemical staining of the intercellular adhesion molecule ICAM-1 may be dependent on inositol phosphate formation in the human renal carcinoma cell line CaKi-1. Inositol Phosphates 162-180 interferon gamma Homo sapiens 28-44 7908588-1 1993 We have recently shown that interferon-gamma (IFN-gamma) stimulated immunocytochemical staining of the intercellular adhesion molecule ICAM-1 may be dependent on inositol phosphate formation in the human renal carcinoma cell line CaKi-1. Inositol Phosphates 162-180 interferon gamma Homo sapiens 46-55 7908588-4 1993 Preincubation with PT or CT for 24 h also inhibited IFN-gamma induced inositol 1-monophosphate (Ins 1-P), inositol 1,4 bisphosphate (Ins 1,4-P2) and inositol 1,4,5 trisphosphate (Ins 1,4,5-P3) formation. Inositol 1,4,5-Trisphosphate 179-191 interferon gamma Homo sapiens 52-61 7908588-2 1993 In the present study we investigated the possible role of GTP-binding proteins (G-proteins) during IFN-gamma signalling. Guanosine Triphosphate 58-61 interferon gamma Homo sapiens 99-108 7908588-5 1993 Our findings suggest that IFN-gamma induced ICAM-1 staining and inositol phosphate formation in CaKi-1 cells is dependent on a PT and CT sensitive signalling pathway. Inositol Phosphates 64-82 interferon gamma Homo sapiens 26-35 7908588-4 1993 Preincubation with PT or CT for 24 h also inhibited IFN-gamma induced inositol 1-monophosphate (Ins 1-P), inositol 1,4 bisphosphate (Ins 1,4-P2) and inositol 1,4,5 trisphosphate (Ins 1,4,5-P3) formation. inositol 1-phosphate 70-94 interferon gamma Homo sapiens 52-61 7908588-4 1993 Preincubation with PT or CT for 24 h also inhibited IFN-gamma induced inositol 1-monophosphate (Ins 1-P), inositol 1,4 bisphosphate (Ins 1,4-P2) and inositol 1,4,5 trisphosphate (Ins 1,4,5-P3) formation. inositol 1-phosphate 96-103 interferon gamma Homo sapiens 52-61 1334553-15 1992 Activation of FcRF gamma by IFN-gamma was inhibited by pretreatment with 500 nM staurosporin and 25 microM phenyl arsine oxide. Staurosporine 80-92 interferon gamma Homo sapiens 28-37 7908588-4 1993 Preincubation with PT or CT for 24 h also inhibited IFN-gamma induced inositol 1-monophosphate (Ins 1-P), inositol 1,4 bisphosphate (Ins 1,4-P2) and inositol 1,4,5 trisphosphate (Ins 1,4,5-P3) formation. inositol 1,4-bis(phosphate) 106-131 interferon gamma Homo sapiens 52-61 1334553-15 1992 Activation of FcRF gamma by IFN-gamma was inhibited by pretreatment with 500 nM staurosporin and 25 microM phenyl arsine oxide. oxophenylarsine 107-126 interferon gamma Homo sapiens 28-37 1281555-0 1992 Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. Tyrosine 42-50 interferon gamma Homo sapiens 31-40 1465386-5 1992 By mutating each individual residue within this sequence to alanine, three residues (Tyr-440, Asp-441, and His-444) were identified as being critical for IFN-gamma-dependent (i) upregulation of major histocompatibility complex class I proteins, (ii) activation of the IFN regulatory factor 1 gene, and (iii) stimulation of cells to produce nitric oxide. Alanine 60-67 interferon gamma Homo sapiens 154-163 1465386-5 1992 By mutating each individual residue within this sequence to alanine, three residues (Tyr-440, Asp-441, and His-444) were identified as being critical for IFN-gamma-dependent (i) upregulation of major histocompatibility complex class I proteins, (ii) activation of the IFN regulatory factor 1 gene, and (iii) stimulation of cells to produce nitric oxide. Tyrosine 85-88 interferon gamma Homo sapiens 154-163 1465386-5 1992 By mutating each individual residue within this sequence to alanine, three residues (Tyr-440, Asp-441, and His-444) were identified as being critical for IFN-gamma-dependent (i) upregulation of major histocompatibility complex class I proteins, (ii) activation of the IFN regulatory factor 1 gene, and (iii) stimulation of cells to produce nitric oxide. Aspartic Acid 94-97 interferon gamma Homo sapiens 154-163 1465386-5 1992 By mutating each individual residue within this sequence to alanine, three residues (Tyr-440, Asp-441, and His-444) were identified as being critical for IFN-gamma-dependent (i) upregulation of major histocompatibility complex class I proteins, (ii) activation of the IFN regulatory factor 1 gene, and (iii) stimulation of cells to produce nitric oxide. Histidine 107-110 interferon gamma Homo sapiens 154-163 1465386-5 1992 By mutating each individual residue within this sequence to alanine, three residues (Tyr-440, Asp-441, and His-444) were identified as being critical for IFN-gamma-dependent (i) upregulation of major histocompatibility complex class I proteins, (ii) activation of the IFN regulatory factor 1 gene, and (iii) stimulation of cells to produce nitric oxide. Nitric Oxide 340-352 interferon gamma Homo sapiens 154-163 1465386-7 1992 Subsequent mutational analysis of all five of the IFN-gamma receptor"s intracellular tyrosine residues revealed that Tyr-440 was the sole tyrosine required for receptor activity. Tyrosine 85-93 interferon gamma Homo sapiens 50-59 1465386-7 1992 Subsequent mutational analysis of all five of the IFN-gamma receptor"s intracellular tyrosine residues revealed that Tyr-440 was the sole tyrosine required for receptor activity. Tyrosine 117-120 interferon gamma Homo sapiens 50-59 1465386-7 1992 Subsequent mutational analysis of all five of the IFN-gamma receptor"s intracellular tyrosine residues revealed that Tyr-440 was the sole tyrosine required for receptor activity. Tyrosine 138-146 interferon gamma Homo sapiens 50-59 1465386-8 1992 These results thus identify a unique sequence in the IFN-gamma receptor that is required for initiation of IFN-gamma-dependent biologic responses and highlight the importance of the hydroxyl side chain of Tyr-440 in this process. Tyrosine 205-208 interferon gamma Homo sapiens 53-62 1465386-8 1992 These results thus identify a unique sequence in the IFN-gamma receptor that is required for initiation of IFN-gamma-dependent biologic responses and highlight the importance of the hydroxyl side chain of Tyr-440 in this process. Tyrosine 205-208 interferon gamma Homo sapiens 107-116 1361720-2 1992 STUDY DESIGN: The tritiated thymidine incorporation assay was used to assess the effect of interferon gamma on proliferation. Tritiated thymidine 18-37 interferon gamma Homo sapiens 91-107 1281555-4 1992 The IFN-gamma-dependent activation of the 91-kilodalton DNA binding protein required cytoplasmic phosphorylation of the protein on tyrosine. Tyrosine 131-139 interferon gamma Homo sapiens 4-13 1450172-4 1992 Recombinant human IFN-gamma (1-100 units/ml), in a dose-dependent fashion, stimulated cell multiplication and [3H]thymidine and 5-bromo-2"-deoxyuridine incorporation into DNA by cultured arterial SMCs that had been growth arrested by culturing in 1% plasma-derived serum for 5 days. Tritium 111-113 interferon gamma Homo sapiens 18-27 1450172-4 1992 Recombinant human IFN-gamma (1-100 units/ml), in a dose-dependent fashion, stimulated cell multiplication and [3H]thymidine and 5-bromo-2"-deoxyuridine incorporation into DNA by cultured arterial SMCs that had been growth arrested by culturing in 1% plasma-derived serum for 5 days. Thymidine 114-123 interferon gamma Homo sapiens 18-27 1450172-4 1992 Recombinant human IFN-gamma (1-100 units/ml), in a dose-dependent fashion, stimulated cell multiplication and [3H]thymidine and 5-bromo-2"-deoxyuridine incorporation into DNA by cultured arterial SMCs that had been growth arrested by culturing in 1% plasma-derived serum for 5 days. Bromodeoxyuridine 128-151 interferon gamma Homo sapiens 18-27 1451181-7 1992 Treatment with dexamethasone reduced Fc gamma RI mRNA levels to 0.6-fold of baseline and inhibited by 20-60% the increase in mRNA observed after treatment of the U937 cells with IFN-gamma. Dexamethasone 15-28 interferon gamma Homo sapiens 178-187 1288731-11 1992 The production of interferon-gamma was stimulated 6- to 10-fold in the presence of 1-5 micrograms/ml BN 52205, BN 52211 and ARA-C. Cytarabine 124-129 interferon gamma Homo sapiens 18-34 1290416-1 1992 T-cell-derived lymphokine, IFN-gamma, has potent effects on B-cell differentiation and leukotriene C4 production in leukocytes, and inhibits the effect of IL-4 on IgE production. Leukotriene C4 87-101 interferon gamma Homo sapiens 27-36 1451181-9 1992 Cotreatment of the IFN-gamma-stimulated monocytes with dexamethasone resulted in a 160% further increase in Fc gamma RI expression. Dexamethasone 55-68 interferon gamma Homo sapiens 19-28 1337336-5 1992 Vitamin D3 enhanced IFN-gamma-induced C4 synthesis by U937 cells. Cholecalciferol 0-10 interferon gamma Homo sapiens 20-29 1337266-3 1992 Co-culture of small numbers of lymphocytes from silica-injected animals with AM induced enhanced secretion of fibroblast growth factor activity which was comparable to the maximal response elicited by recombinant interferon-gamma. Silicon Dioxide 48-54 interferon gamma Homo sapiens 213-229 1431124-3 1992 Phorbol esters previously have been demonstrated to increase human IFN-gamma gene expression after treatment of a murine T cell line (Cl 9) that has been transfected with human IFN-gamma genomic DNA. Phorbol Esters 0-14 interferon gamma Homo sapiens 67-76 1493924-7 1992 Finally, 1,25(OH)2D3 inhibited IFN-gamma in both PHA- and OKT3-activated cells, but these effects were attenuated in the presence of PMA. Calcitriol 9-20 interferon gamma Homo sapiens 31-40 1431124-3 1992 Phorbol esters previously have been demonstrated to increase human IFN-gamma gene expression after treatment of a murine T cell line (Cl 9) that has been transfected with human IFN-gamma genomic DNA. Phorbol Esters 0-14 interferon gamma Homo sapiens 177-186 1464732-4 1992 Ethanol also increased TGF beta production in interferon gamma (IFN gamma-activated M phi in response to MDP stimulus (P < 0.05). Ethanol 0-7 interferon gamma Homo sapiens 46-62 1464732-4 1992 Ethanol also increased TGF beta production in interferon gamma (IFN gamma-activated M phi in response to MDP stimulus (P < 0.05). Ethanol 0-7 interferon gamma Homo sapiens 64-73 1464737-6 1992 Interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) contributed to TBH CD8+ T cell-mediated suppression. tbh 69-72 interferon gamma Homo sapiens 0-16 1333123-4 1992 Functional activity of recombinant vIL-10 was shown by the inhibition of interferon-gamma production by activated leukocytes. vil-10 35-41 interferon gamma Homo sapiens 73-89 1464737-6 1992 Interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) contributed to TBH CD8+ T cell-mediated suppression. tbh 69-72 interferon gamma Homo sapiens 18-27 1464737-7 1992 Blocking studies using monoclonal antibodies (mAb) in conjunction with indomethacin suggested that cytokine networks involving IFN-gamma, IL-4, and PGE2 were disrupted during tumor growth and promoted TBH CD8+ T cell suppression. Indomethacin 71-83 interferon gamma Homo sapiens 127-136 1464737-7 1992 Blocking studies using monoclonal antibodies (mAb) in conjunction with indomethacin suggested that cytokine networks involving IFN-gamma, IL-4, and PGE2 were disrupted during tumor growth and promoted TBH CD8+ T cell suppression. tbh 201-204 interferon gamma Homo sapiens 127-136 1477185-0 1992 Contrasting effects of interferon-gamma and interleukin-4 on neopterin generation from human adherent monocytes. Neopterin 61-70 interferon gamma Homo sapiens 23-39 1477185-2 1992 Neopterin appears to be produced by human macrophages specifically stimulated with interferon-gamma (IFN-gamma). Neopterin 0-9 interferon gamma Homo sapiens 83-99 1477185-2 1992 Neopterin appears to be produced by human macrophages specifically stimulated with interferon-gamma (IFN-gamma). Neopterin 0-9 interferon gamma Homo sapiens 101-110 1477185-10 1992 These findings indicate that IL-4 can regulate the synthesis of neopterin by adherent blood mononuclear cells and provide further evidence that LPS-induced neopterin in macrophages may act by IFN-gamma-independent mechanisms. Neopterin 156-165 interferon gamma Homo sapiens 192-201 1418895-3 1992 Interferon gamma significantly enhanced the cytotoxicity of tumor necrosis factor alpha with dactinomycin on all six cell lines investigated, while in four of six cell lines the cytotoxicity of tumor necrosis factor alpha with doxorubicin was significantly augmented by interferon gamma. Dactinomycin 93-105 interferon gamma Homo sapiens 0-16 1418895-3 1992 Interferon gamma significantly enhanced the cytotoxicity of tumor necrosis factor alpha with dactinomycin on all six cell lines investigated, while in four of six cell lines the cytotoxicity of tumor necrosis factor alpha with doxorubicin was significantly augmented by interferon gamma. Doxorubicin 227-238 interferon gamma Homo sapiens 0-16 1418895-3 1992 Interferon gamma significantly enhanced the cytotoxicity of tumor necrosis factor alpha with dactinomycin on all six cell lines investigated, while in four of six cell lines the cytotoxicity of tumor necrosis factor alpha with doxorubicin was significantly augmented by interferon gamma. Doxorubicin 227-238 interferon gamma Homo sapiens 270-286 1292629-6 1992 The tumor promoters PMA and teleocidin appeared to enhance this IFN-gamma expression in nearly every B cell line. teleocidins 28-38 interferon gamma Homo sapiens 64-73 1292630-2 1992 Highly purified T cells stimulated with interleukin 7 (IL-7), in the absence of co-mitogen, secreted IL-2, IL-4, IL-6 and interferon gamma (IFN-gamma) upon restimulation with phorbol ester and ionomycin. Phorbol Esters 175-188 interferon gamma Homo sapiens 122-149 1363420-0 1992 Interferon-gamma response region in the promoter of the class II MHC gene, DPA. dpa 75-78 interferon gamma Homo sapiens 0-16 1337987-1 1992 1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] inhibits lymphocyte proliferation and production of antibodies and lymphokines such as interleukin (IL)-2 and interferon gamma. 1,25-dihydroxyvitamin d3 [1,25-(oh)2d3 0-38 interferon gamma Homo sapiens 150-166 1291559-3 1992 Neither IL-1 nor TNF alpha had significant effects on human chorionic gonadotrophin (HCG)-stimulated progesterone production, whereas IFN gamma (1-10 ng/ml) significantly reduced HCG-stimulated progesterone production by 26-37%. Progesterone 194-206 interferon gamma Homo sapiens 134-143 1291559-5 1992 In contrast, the combination of TNF alpha (1 ng/ml) and IFN gamma (10 ng/ml) acted synergistically to markedly inhibit HCG-stimulated progesterone production by 81%. Progesterone 134-146 interferon gamma Homo sapiens 56-65 1291559-7 1992 The combination of TNF alpha and IFN gamma also markedly inhibited follicle stimulating hormone (FSH)-stimulated oestradiol production by 97%, a significantly greater inhibition than that obtained with either cytokine alone. Estradiol 113-123 interferon gamma Homo sapiens 33-42 1363420-1 1992 The class II MHC gene DPA is inducible by interferon-gamma (IFN-gamma), whereas the DQB gene is not inducible in most cell types. dpa 22-25 interferon gamma Homo sapiens 42-58 1490726-9 1992 Treatment of U937 cells with interferon-gamma up-regulated their APG binding capacity along with the expression of the integrin CD 11 b and the CD 14 molecule, whereas monocytes exposed to interferon-gamma showed an increased binding of APG associated with an elevated expression of the galactose specific lectin Mac-2. Galactose 287-296 interferon gamma Homo sapiens 29-45 1490726-9 1992 Treatment of U937 cells with interferon-gamma up-regulated their APG binding capacity along with the expression of the integrin CD 11 b and the CD 14 molecule, whereas monocytes exposed to interferon-gamma showed an increased binding of APG associated with an elevated expression of the galactose specific lectin Mac-2. Galactose 287-296 interferon gamma Homo sapiens 189-205 1363420-1 1992 The class II MHC gene DPA is inducible by interferon-gamma (IFN-gamma), whereas the DQB gene is not inducible in most cell types. dpa 22-25 interferon gamma Homo sapiens 60-69 1357073-7 1992 The ability of supernatant fluids from unstimulated and phorbol diester-stimulated cell lines to induce interferon gamma (IFN-gamma) production from T and NK cells, one of the effects of NKSF/IL-12, parallels the levels of production of the p70 heterodimer, known to be the biologically active form of NKSF/IL-12. phorbol 56-63 interferon gamma Homo sapiens 104-131 1483927-1 1992 Based on the previous finding that certain 30-mer single-stranded oligodeoxyribonucleotides (oligonucleotides) having particular 6-mer palindromic sequences could induce interferon-alpha and -gamma, and enhance natural killer activity, the present study was carried out to clarify the entire relationship between the activity and the sequence of 30-mer oligonucleotides. Oligodeoxyribonucleotides 66-91 interferon gamma Homo sapiens 170-197 1401925-7 1992 The addition in bulk cultures before cloning of IFN-gamma or IFN-alpha favored the development of TES-specific and Poa p IX-specific T cells into T cell clones showing a Th0 or even a Th1, rather than a Th2, cytokine profile. TES 98-101 interferon gamma Homo sapiens 48-57 1483927-1 1992 Based on the previous finding that certain 30-mer single-stranded oligodeoxyribonucleotides (oligonucleotides) having particular 6-mer palindromic sequences could induce interferon-alpha and -gamma, and enhance natural killer activity, the present study was carried out to clarify the entire relationship between the activity and the sequence of 30-mer oligonucleotides. Oligonucleotides 93-109 interferon gamma Homo sapiens 170-197 1483927-1 1992 Based on the previous finding that certain 30-mer single-stranded oligodeoxyribonucleotides (oligonucleotides) having particular 6-mer palindromic sequences could induce interferon-alpha and -gamma, and enhance natural killer activity, the present study was carried out to clarify the entire relationship between the activity and the sequence of 30-mer oligonucleotides. Oligonucleotides 353-369 interferon gamma Homo sapiens 170-197 1465184-2 1992 Clinical studies have established that sustained elevations of quinolinic acid, L-kynurenine and kynurenic acid within the cerebrospinal fluid occur in patients with a broad spectrum of inflammatory diseases and correlate with markers of immune activation and interferon-gamma activity. Quinolinic Acid 63-78 interferon gamma Homo sapiens 260-276 1465184-2 1992 Clinical studies have established that sustained elevations of quinolinic acid, L-kynurenine and kynurenic acid within the cerebrospinal fluid occur in patients with a broad spectrum of inflammatory diseases and correlate with markers of immune activation and interferon-gamma activity. Kynurenine 80-92 interferon gamma Homo sapiens 260-276 1465184-2 1992 Clinical studies have established that sustained elevations of quinolinic acid, L-kynurenine and kynurenic acid within the cerebrospinal fluid occur in patients with a broad spectrum of inflammatory diseases and correlate with markers of immune activation and interferon-gamma activity. Kynurenic Acid 97-111 interferon gamma Homo sapiens 260-276 1400493-6 1992 We illustrate our approach by quantifying the effect of the immunosuppressor cyclosporin A on the accumulation of interleukin-4, interferon-gamma, and interleukin-2 receptor mRNAs in phytohemagglutinin-stimulated human peripheral blood mononuclear cells. Cyclosporine 77-90 interferon gamma Homo sapiens 129-145 1397282-0 1992 Tyrosine phosphorylation is an early and requisite signal induced by interferon-gamma in HL-60 cells. Tyrosine 0-8 interferon gamma Homo sapiens 69-85 1327163-9 1992 Preincubation of macrophages with interferon-gamma increased the cells ability to generate reactive nitrogen metabolites. reactive nitrogen 91-108 interferon gamma Homo sapiens 34-50 1397282-7 1992 Treatment of HL-60 cells with the tyrosine kinase inhibitors, genistein and herbimycin A, inhibited both IFN gamma-stimulated tyrosine phosphorylation and IFN gamma-induced Fc receptor expression. herbimycin 76-88 interferon gamma Homo sapiens 155-164 1397282-3 1992 Therefore, we tested the role of tyrosine phosphorylation in signalling induced by IFN gamma. Tyrosine 33-41 interferon gamma Homo sapiens 83-92 1397282-7 1992 Treatment of HL-60 cells with the tyrosine kinase inhibitors, genistein and herbimycin A, inhibited both IFN gamma-stimulated tyrosine phosphorylation and IFN gamma-induced Fc receptor expression. Tyrosine 34-42 interferon gamma Homo sapiens 105-114 1397282-7 1992 Treatment of HL-60 cells with the tyrosine kinase inhibitors, genistein and herbimycin A, inhibited both IFN gamma-stimulated tyrosine phosphorylation and IFN gamma-induced Fc receptor expression. Tyrosine 34-42 interferon gamma Homo sapiens 155-164 1397282-4 1992 IFN gamma was found to induce rapid tyrosine phosphorylation of several proteins in HL-60 cells. Tyrosine 36-44 interferon gamma Homo sapiens 0-9 1397282-8 1992 Thus, increased tyrosine phosphorylation appears to be an obligatory early and proximal signal mediating at least some of the later cellular responses induced by IFN gamma in HL-60 cells. Tyrosine 16-24 interferon gamma Homo sapiens 162-171 1397282-6 1992 Tyrosine phosphorylation was dependent on receptor occupation and was maximally stimulated by 10 ng/ml IFN gamma. Tyrosine 0-8 interferon gamma Homo sapiens 103-112 1397282-7 1992 Treatment of HL-60 cells with the tyrosine kinase inhibitors, genistein and herbimycin A, inhibited both IFN gamma-stimulated tyrosine phosphorylation and IFN gamma-induced Fc receptor expression. Genistein 62-71 interferon gamma Homo sapiens 105-114 1397282-7 1992 Treatment of HL-60 cells with the tyrosine kinase inhibitors, genistein and herbimycin A, inhibited both IFN gamma-stimulated tyrosine phosphorylation and IFN gamma-induced Fc receptor expression. Genistein 62-71 interferon gamma Homo sapiens 155-164 1397282-7 1992 Treatment of HL-60 cells with the tyrosine kinase inhibitors, genistein and herbimycin A, inhibited both IFN gamma-stimulated tyrosine phosphorylation and IFN gamma-induced Fc receptor expression. herbimycin 76-88 interferon gamma Homo sapiens 105-114 1446859-0 1992 Inhibition of binding of interferon-gamma to its receptor by salicylates used in inflammatory bowel disease. Salicylates 61-72 interferon gamma Homo sapiens 25-41 1446859-1 1992 5-Aminosalicylic acid (5ASA), 4ASA, their N-acetylated metabolites N-acetyl-5ASA and N-acetyl-4ASA, olsalazine, and colchicine impair interferon-gamma (IFN gamma) induced HLA-DR expression on a colonic cell line, HT-29. Mesalamine 0-21 interferon gamma Homo sapiens 134-150 1446859-1 1992 5-Aminosalicylic acid (5ASA), 4ASA, their N-acetylated metabolites N-acetyl-5ASA and N-acetyl-4ASA, olsalazine, and colchicine impair interferon-gamma (IFN gamma) induced HLA-DR expression on a colonic cell line, HT-29. Mesalamine 0-21 interferon gamma Homo sapiens 152-161 1446859-1 1992 5-Aminosalicylic acid (5ASA), 4ASA, their N-acetylated metabolites N-acetyl-5ASA and N-acetyl-4ASA, olsalazine, and colchicine impair interferon-gamma (IFN gamma) induced HLA-DR expression on a colonic cell line, HT-29. n-acetyl-4asa 85-98 interferon gamma Homo sapiens 134-150 1446859-1 1992 5-Aminosalicylic acid (5ASA), 4ASA, their N-acetylated metabolites N-acetyl-5ASA and N-acetyl-4ASA, olsalazine, and colchicine impair interferon-gamma (IFN gamma) induced HLA-DR expression on a colonic cell line, HT-29. n-acetyl-4asa 85-98 interferon gamma Homo sapiens 152-161 1446859-10 1992 At concentrations found in the rectal lumen, the salicylates used in inflammatory bowel disease impair the binding of IFN gamma to its receptor on colonic epithelial cells. Salicylates 49-60 interferon gamma Homo sapiens 118-127 1398953-1 1992 Gamma interferon (IFN-gamma) affects tryptophan metabolism by mediating the expression of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA synthetase. Tryptophan 37-47 interferon gamma Homo sapiens 0-27 1394436-13 1992 AG126 enhanced IFN-gamma, IL-1, and IL-6 production in PBM that were costimulated with the stress stimuli heat shock and phenylarsine oxide. AG 127 0-5 interferon gamma Homo sapiens 15-24 1398953-2 1992 In the present study, we investigated the role of indoleamine 2,3-dioxygenase-mediated tryptophan depletion in the induction of tryptophanyl-tRNA synthetase by IFN-gamma. Tryptophan 87-97 interferon gamma Homo sapiens 160-169 1328343-6 1992 By contrast, stimulation with phorbol esters and ionophore, which bypass surface receptor signaling, induced comparable amounts of IL-4 and IFN-gamma in older and young subjects. Phorbol Esters 30-44 interferon gamma Homo sapiens 140-149 1401082-2 1992 We characterized the mechanisms by which recombinant (r) tumor necrosis factor (TNF), IFN-gamma, and IL-1, alone and in combination, regulate human lung fibroblast hyaluronic acid (HA) production. Hyaluronic Acid 164-179 interferon gamma Homo sapiens 86-95 1401082-2 1992 We characterized the mechanisms by which recombinant (r) tumor necrosis factor (TNF), IFN-gamma, and IL-1, alone and in combination, regulate human lung fibroblast hyaluronic acid (HA) production. Hyaluronic Acid 181-183 interferon gamma Homo sapiens 86-95 1413071-0 1992 Mechanism of a clinically relevant protocol to induce tolerance: peritransplant spleen cells plus cyclosporine suppress IL-2 and IFN-gamma production. Cyclosporine 98-110 interferon gamma Homo sapiens 129-138 1526278-8 1992 In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2. Phosphatidylcholines 80-99 interferon gamma Homo sapiens 219-228 1334711-2 1992 Preincubation of human monocytes with vIL-10, like human IL-10, induced smaller amounts of interferon-gamma (IFN-gamma) mRNA in activated human peripheral blood mononuclear cells (PBMNCs) than nonpreincubation, indicating that vIL-10 acts principally on monocytes. vil-10 38-44 interferon gamma Homo sapiens 91-107 1334711-2 1992 Preincubation of human monocytes with vIL-10, like human IL-10, induced smaller amounts of interferon-gamma (IFN-gamma) mRNA in activated human peripheral blood mononuclear cells (PBMNCs) than nonpreincubation, indicating that vIL-10 acts principally on monocytes. vil-10 38-44 interferon gamma Homo sapiens 109-118 1334711-6 1992 Additions of IFN-gamma, macrophage colony-stimulating factor (M-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF), which prime monocyte activation and induce O2- production, were also affected by the reciprocal effect of vIL-10. Superoxides 174-176 interferon gamma Homo sapiens 13-22 1526278-5 1992 Treatment of pre-labeled LAN-5 cells with a receptor-saturating concentration of IFN-gamma led to a time-dependent release of [3H]arachidonic acid into the culture media and generation of [32P]lysophosphatidylcholine. [3h]arachidonic acid 126-146 interferon gamma Homo sapiens 81-90 1526278-8 1992 In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2. Phosphatidylcholines 259-278 interferon gamma Homo sapiens 125-134 1526278-8 1992 In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2. Phosphatidylcholines 259-278 interferon gamma Homo sapiens 219-228 1526278-5 1992 Treatment of pre-labeled LAN-5 cells with a receptor-saturating concentration of IFN-gamma led to a time-dependent release of [3H]arachidonic acid into the culture media and generation of [32P]lysophosphatidylcholine. 32p]lysophosphatidylcholine 189-216 interferon gamma Homo sapiens 81-90 1526278-6 1992 Pretreatment of cultures with the phospholipase A2 inhibitor, bromophenacyl bromide, markedly inhibited both [3H]arachidonic acid release and lysophosphatidylcholine production induced by IFN-gamma treatment. 4-bromophenacyl bromide 62-83 interferon gamma Homo sapiens 188-197 1325288-5 1992 Treatment of these cells with gamma-interferon (IFN-gamma) resulted in morphological changes accompanied by a significant increase in overall cell-associated MIBG. 3-Iodobenzylguanidine 158-162 interferon gamma Homo sapiens 48-57 1526278-6 1992 Pretreatment of cultures with the phospholipase A2 inhibitor, bromophenacyl bromide, markedly inhibited both [3H]arachidonic acid release and lysophosphatidylcholine production induced by IFN-gamma treatment. [3h]arachidonic acid 109-129 interferon gamma Homo sapiens 188-197 1526278-6 1992 Pretreatment of cultures with the phospholipase A2 inhibitor, bromophenacyl bromide, markedly inhibited both [3H]arachidonic acid release and lysophosphatidylcholine production induced by IFN-gamma treatment. Lysophosphatidylcholines 142-165 interferon gamma Homo sapiens 188-197 1526278-7 1992 Pretreatment of LAN-5 cells with nordihydroguaiaretic acid, a lipoxygenase inhibitor, or with indomethacin, a cyclooxygenase inhibitor, amplified the release of [3H]arachidonic acid and production of lysophosphatidylcholine induced by non-saturating concentrations of IFN-gamma. Masoprocol 33-58 interferon gamma Homo sapiens 268-277 1526278-7 1992 Pretreatment of LAN-5 cells with nordihydroguaiaretic acid, a lipoxygenase inhibitor, or with indomethacin, a cyclooxygenase inhibitor, amplified the release of [3H]arachidonic acid and production of lysophosphatidylcholine induced by non-saturating concentrations of IFN-gamma. Indomethacin 94-106 interferon gamma Homo sapiens 268-277 1526278-8 1992 In parallel, and with the same time-dependent effect, a significant decrease in phosphatidylcholine labeling was observed in IFN-gamma-treated cells, further indicating that a potential signal transduction mechanism of IFN-gamma is the hydrolysis of membrane phosphatidylcholine by phospholipase A2. Phosphatidylcholines 80-99 interferon gamma Homo sapiens 125-134 1325288-6 1992 Desimipramine, but not reserpine, easily depleted IFN-gamma-treated LAN-5 cells of their MIBG content. Desipramine 0-13 interferon gamma Homo sapiens 50-59 1325288-6 1992 Desimipramine, but not reserpine, easily depleted IFN-gamma-treated LAN-5 cells of their MIBG content. 3-Iodobenzylguanidine 89-93 interferon gamma Homo sapiens 50-59 1525174-5 1992 Interestingly, interferon-gamma and fibroblast growth factor compete for the same binding domain on heparan sulfate, although they are unrelated proteins. Heparitin Sulfate 100-115 interferon gamma Homo sapiens 15-31 1525174-0 1992 Binding of interferon-gamma to heparan sulfate is restricted to the heparin-like domains and involves carboxylic--but not N-sulfated--groups. Heparitin Sulfate 31-46 interferon gamma Homo sapiens 11-27 1525174-1 1992 Interferon-gamma binds to the glycosaminoglycan part of basement membrane proteoglycan. Glycosaminoglycans 30-47 interferon gamma Homo sapiens 0-16 1525174-4 1992 Furthermore, using heparan sulfate and heparin treated with heparinases I and III, we have shown that the interferon-gamma binding sites are localized on the N-sulfated glucosamine rich domains of the molecule. Heparitin Sulfate 19-34 interferon gamma Homo sapiens 106-122 1525174-4 1992 Furthermore, using heparan sulfate and heparin treated with heparinases I and III, we have shown that the interferon-gamma binding sites are localized on the N-sulfated glucosamine rich domains of the molecule. Heparin 39-46 interferon gamma Homo sapiens 106-122 1525174-4 1992 Furthermore, using heparan sulfate and heparin treated with heparinases I and III, we have shown that the interferon-gamma binding sites are localized on the N-sulfated glucosamine rich domains of the molecule. Glucosamine 169-180 interferon gamma Homo sapiens 106-122 1391120-10 1992 In addition, anti-IFN-gamma antibodies can reverse the T-cell SN-mediated suppression of CFU-GM. Tin 62-64 interferon gamma Homo sapiens 18-27 1525157-0 1992 1H, 13C, and 15N NMR backbone assignments and secondary structure of human interferon-gamma. Hydrogen 0-2 interferon gamma Homo sapiens 75-91 1525157-0 1992 1H, 13C, and 15N NMR backbone assignments and secondary structure of human interferon-gamma. 13c 4-7 interferon gamma Homo sapiens 75-91 1525157-0 1992 1H, 13C, and 15N NMR backbone assignments and secondary structure of human interferon-gamma. 15n 13-16 interferon gamma Homo sapiens 75-91 1525157-1 1992 1H, 13C, and 15N NMR assignments of the protein backbone of human interferon-gamma, a homodimer of 31.4 kDa, have been made using the recently introduced three-dimensional (3D) triple-resonance NMR techniques. Hydrogen 0-2 interferon gamma Homo sapiens 66-82 1525157-1 1992 1H, 13C, and 15N NMR assignments of the protein backbone of human interferon-gamma, a homodimer of 31.4 kDa, have been made using the recently introduced three-dimensional (3D) triple-resonance NMR techniques. 13c 4-7 interferon gamma Homo sapiens 66-82 1525157-1 1992 1H, 13C, and 15N NMR assignments of the protein backbone of human interferon-gamma, a homodimer of 31.4 kDa, have been made using the recently introduced three-dimensional (3D) triple-resonance NMR techniques. 15n 13-16 interferon gamma Homo sapiens 66-82 1356410-0 1992 Differential effect of griseofulvin on interferon-gamma-induced HLA-DR and intercellular adhesion molecule-1 expression of human keratinocytes. Griseofulvin 23-35 interferon gamma Homo sapiens 39-55 1326572-6 1992 In contrast, after 20 hours of preincubation, stimulated cAMP production of PBMCs was significantly diminished, with 63% by IL-1 (40 U/ml, p less than 0.01), with 36% by IL-2 (100 U/ml, p less than 0.05), with 37% by IFN-gamma (1000 U/ml, p less than 0.05), and with 21% by GM-CSF (100 U/ml, p less than 0.05). Cyclic AMP 57-61 interferon gamma Homo sapiens 217-226 1355014-7 1992 Staurosporin, an inhibitor of protein kinases (PKs), partly suppressed IFN-gamma- and PMA-augmented expression of ICAM-1 on EoL-3 and U937 cells, but did not affect PMA-augmented LFA-1 expression, suggesting that staurosporin-sensitive PKs are involved in IFN-gamma- and PMA-augmented ICAM-1 expression but not in PMA-augmented LFA-1 expression. Staurosporine 0-12 interferon gamma Homo sapiens 71-80 1355014-7 1992 Staurosporin, an inhibitor of protein kinases (PKs), partly suppressed IFN-gamma- and PMA-augmented expression of ICAM-1 on EoL-3 and U937 cells, but did not affect PMA-augmented LFA-1 expression, suggesting that staurosporin-sensitive PKs are involved in IFN-gamma- and PMA-augmented ICAM-1 expression but not in PMA-augmented LFA-1 expression. Staurosporine 0-12 interferon gamma Homo sapiens 256-265 1285922-0 1992 Modification of adriamycin-induced cytotoxicity by recombinant human interferon-gamma and/or verapamil in human stomach cancer cells. Doxorubicin 16-26 interferon gamma Homo sapiens 69-85 1285922-1 1992 Recombinant human-interferon-gamma (rH-IFN-gamma) and verapamil (VRP), either alone or in combination, were evaluated in MTT assay for their modification effects on adriamycin-induced cytotoxicity against MKN-45, human stomach adenocarcinoma cells. Doxorubicin 165-175 interferon gamma Homo sapiens 18-34 1432999-0 1992 Cyclosporine and chloroquine synergistically inhibit the interferon-gamma production by CD4 positive and CD8 positive synovial T cell clones derived from a patient with rheumatoid arthritis. Cyclosporine 0-12 interferon gamma Homo sapiens 57-73 1432999-0 1992 Cyclosporine and chloroquine synergistically inhibit the interferon-gamma production by CD4 positive and CD8 positive synovial T cell clones derived from a patient with rheumatoid arthritis. Chloroquine 17-28 interferon gamma Homo sapiens 57-73 1469778-4 1992 Being consistent with this, IFN-gamma induced increased tyrosine phosphorylation and this was inhibited by genistein. Tyrosine 56-64 interferon gamma Homo sapiens 28-37 1386860-5 1992 The CD44+ population includes very immature precursor T cells and produced high titers of IL-2, TNF-alpha, and IFN-gamma upon activation with calcium ionophore and phorbol ester. Calcium 142-149 interferon gamma Homo sapiens 111-120 1386860-5 1992 The CD44+ population includes very immature precursor T cells and produced high titers of IL-2, TNF-alpha, and IFN-gamma upon activation with calcium ionophore and phorbol ester. Phorbol Esters 164-177 interferon gamma Homo sapiens 111-120 1469778-4 1992 Being consistent with this, IFN-gamma induced increased tyrosine phosphorylation and this was inhibited by genistein. Genistein 107-116 interferon gamma Homo sapiens 28-37 1469778-7 1992 These results all suggest that the tyrosine phosphorylation is a critical event in IFN-gamma-inducible IDO gene expression and PKC is not involved in the gene expression. Tyrosine 35-43 interferon gamma Homo sapiens 83-92 1511424-0 1992 Effect of verapamil on the class I major histocompatibility complex antigen expression in K562 chronic myelogenous leukemia cells treated with recombinant human interferon-gamma. Verapamil 10-19 interferon gamma Homo sapiens 161-177 1511424-8 1992 These results indicate that verapamil synergistically interacts with rIFN-gamma on the class I antigen induction in K562 cells irrespective of c-myc gene expression and that class I antigen induction in this cell line may not be relevant to calcium influx triggered by IFN-gamma. Calcium 241-248 interferon gamma Homo sapiens 70-79 1496401-3 1992 IFN-gamma, which activates transcription through a different receptor and different DNA binding sites, also caused tyrosine phosphorylation of one of these proteins. Tyrosine 115-123 interferon gamma Homo sapiens 0-9 1322203-7 1992 We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2). pa682bm 19-26 interferon gamma Homo sapiens 158-167 1322203-7 1992 We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2). pa682bm 19-26 interferon gamma Homo sapiens 226-235 1322203-7 1992 We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2). Tetradecanoylphorbol Acetate 88-119 interferon gamma Homo sapiens 158-167 1322203-7 1992 We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2). Tetradecanoylphorbol Acetate 88-119 interferon gamma Homo sapiens 226-235 1322203-7 1992 We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2). Tetradecanoylphorbol Acetate 121-124 interferon gamma Homo sapiens 158-167 1322203-7 1992 We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2). Tetradecanoylphorbol Acetate 121-124 interferon gamma Homo sapiens 226-235 1322203-7 1992 We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2). indolactam V 133-145 interferon gamma Homo sapiens 158-167 1322203-7 1992 We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2). indolactam V 133-145 interferon gamma Homo sapiens 226-235 1623560-5 1992 Fatty acid incorporation into interferon-gamma-activated monocytes was dramatically increased, particularly for palmitic acid. Fatty Acids 0-10 interferon gamma Homo sapiens 30-46 1623560-5 1992 Fatty acid incorporation into interferon-gamma-activated monocytes was dramatically increased, particularly for palmitic acid. Palmitic Acid 112-125 interferon gamma Homo sapiens 30-46 1386713-3 1992 The response of these cell lines to interferon-gamma was measured in two functional assays: a cell proliferation assay and a cell lysis assay after exposure to interferon-gamma with and without actinomycin-D. Dactinomycin 194-207 interferon gamma Homo sapiens 36-52 1386713-6 1992 After treatment with interferon-gamma actinomycin-D, each choriocarcinoma cell line exhibited dose-dependent cell lysis; lysis of Jar was significantly less than that of either BeWo or JEG-3. Dactinomycin 38-51 interferon gamma Homo sapiens 21-37 1623560-8 1992 Incorporation of arachidonic acid into phosphatidylinositol and serine into phosphatidylethanolamine was also increased in the interferon-gamma-activated monocytes. Arachidonic Acid 17-33 interferon gamma Homo sapiens 127-143 1623560-8 1992 Incorporation of arachidonic acid into phosphatidylinositol and serine into phosphatidylethanolamine was also increased in the interferon-gamma-activated monocytes. Phosphatidylinositols 39-59 interferon gamma Homo sapiens 127-143 1623560-8 1992 Incorporation of arachidonic acid into phosphatidylinositol and serine into phosphatidylethanolamine was also increased in the interferon-gamma-activated monocytes. Serine 64-70 interferon gamma Homo sapiens 127-143 1623560-8 1992 Incorporation of arachidonic acid into phosphatidylinositol and serine into phosphatidylethanolamine was also increased in the interferon-gamma-activated monocytes. phosphatidylethanolamine 76-100 interferon gamma Homo sapiens 127-143 1623560-10 1992 These results suggest that IFN-gamma activation induces a short-term stimulation of phospholipid metabolism which does not alter the gross lipid composition. Phospholipids 84-96 interferon gamma Homo sapiens 27-36 1322853-9 1992 Macrophage/monocytes in vitro synthesized [13C6]quinolinic acid from [13C6]L-tryptophan, particularly when stimulated by interferon-gamma. [13c6]quinolinic acid 42-63 interferon gamma Homo sapiens 121-137 1499439-9 1992 Furthermore, 5-aminosalicylic acid partially protected Cl.16E cells against cellular injury caused by IFN-gamma and TNF-alpha. Mesalamine 13-34 interferon gamma Homo sapiens 102-111 1322853-9 1992 Macrophage/monocytes in vitro synthesized [13C6]quinolinic acid from [13C6]L-tryptophan, particularly when stimulated by interferon-gamma. [13c6]l-tryptophan 69-87 interferon gamma Homo sapiens 121-137 1383133-3 1992 Both IL-4 (> or = 10 pM) and the glucocorticoid, dexamethasone (10(-7) M), inhibited G-CSF production in the LPS-treated monocytes; in contrast, IFN-gamma had a weak potentiating effect on the LPS action. Dexamethasone 52-65 interferon gamma Homo sapiens 148-157 1524839-8 1992 In the case of M. tuberculosis, the IFN gamma treatment alone endowed both monocytes and macrophages with significant bacteriostatic activity which was further potentiated by the addition of IND. Indomethacin 191-194 interferon gamma Homo sapiens 36-45 1639344-5 1992 Furthermore, ursodeoxycholic acid suppressed interleukin-2 and interleukin-4 production induced by concanavalin A and interferon-gamma production induced by polyinosinic-polycytidylic acid, but it did not affect interleukin-1 and interleukin-6 production induced by lipopolysaccharide in peripheral blood mononuclear cells. Ursodeoxycholic Acid 13-33 interferon gamma Homo sapiens 118-134 1639344-5 1992 Furthermore, ursodeoxycholic acid suppressed interleukin-2 and interleukin-4 production induced by concanavalin A and interferon-gamma production induced by polyinosinic-polycytidylic acid, but it did not affect interleukin-1 and interleukin-6 production induced by lipopolysaccharide in peripheral blood mononuclear cells. Poly I-C 157-188 interferon gamma Homo sapiens 118-134 1324000-9 1992 The antiviral function of poly A:poly U-treated spleen cells appeared to be due mainly to the action of IFN gamma produced by T cells. Poly A 26-32 interferon gamma Homo sapiens 104-113 1324000-9 1992 The antiviral function of poly A:poly U-treated spleen cells appeared to be due mainly to the action of IFN gamma produced by T cells. Poly U 33-39 interferon gamma Homo sapiens 104-113 1324288-4 1992 IL-4 also suppressed O2- production by AMs induced by the synergistic actions of muramyl dipeptide (norMDP) and IFN-gamma. Superoxides 21-23 interferon gamma Homo sapiens 112-121 1324288-0 1992 Differential effects of interleukin-4 on superoxide anion production by human alveolar macrophages stimulated with lipopolysaccharide and interferon-gamma. Superoxides 41-57 interferon gamma Homo sapiens 138-154 1324288-6 1992 AMs also showed high O2- production when stimulated with IFN-gamma alone. Superoxides 21-23 interferon gamma Homo sapiens 57-66 1324288-7 1992 In contrast to its suppression of O2- production by LPS-stimulated AMs, IL-4 enhanced O2- production by AMs stimulated with IFN-gamma. Superoxides 86-88 interferon gamma Homo sapiens 124-133 1353306-3 1992 HTEC monolayers also exhibited no significant basal ICAM-1 expression but, in contrast to HUVEC monolayers, had marked increases in ICAM-1 expression and ICAM-1-dependent PMN adherence only after incubation with IFN-gamma (and not after IL-1 beta or TNF-alpha) treatment. htec 0-4 interferon gamma Homo sapiens 212-221 1504058-8 1992 It is suggested from these results that the cytotoxicity of LAMs is regulated by CSF-1, IL-1, IFN-gamma, and TNF, and that the production of cytotoxic molecules is involved in cell-mediated killing by LAMs. lipoarabinomannan 60-64 interferon gamma Homo sapiens 94-103 1497665-4 1992 Human macrophages were viable and metabolically active as indicated by the MTT assay, and their respiratory burst response to phorbol myristate acetate was increased following incubation with Interferon-gamma, as expected for typical macrophages. Tetradecanoylphorbol Acetate 126-151 interferon gamma Homo sapiens 192-208 1444321-8 1992 AZT was not cytotoxic at less than 10 microM as assessed by cell viability, cell protein, and interferon-gamma-activated H2O2-release. Hydrogen Peroxide 121-125 interferon gamma Homo sapiens 94-110 1385767-6 1992 Gold-salt treatment led to a slightly delayed and enhanced secretion of TNF-alpha and IL-1 beta, an enhanced secretion of IL-2 and a restored secretion of IFN-gamma. gold-salt 0-9 interferon gamma Homo sapiens 155-164 1515553-5 1992 In contrast, despite variation between individual donors, in general Dex weakly inhibited both constitutive and IFN-gamma- or IL-4-induced HLA-DR expression. Dexamethasone 69-72 interferon gamma Homo sapiens 112-121 1380951-3 1992 While 1 microgram/ml CSA and 0.1 microgram/ml FK 506 completely suppressed PHA-stimulated accumulation of mRNA for IL2, IL4, IL9, GM-CSF, TNF-alpha and IFN-gamma in PBMC, flu, keto and TGF-beta failed to inhibit any (except TNF-alpha blocked by TGF-beta). Cyclosporine 21-24 interferon gamma Homo sapiens 152-161 1380951-3 1992 While 1 microgram/ml CSA and 0.1 microgram/ml FK 506 completely suppressed PHA-stimulated accumulation of mRNA for IL2, IL4, IL9, GM-CSF, TNF-alpha and IFN-gamma in PBMC, flu, keto and TGF-beta failed to inhibit any (except TNF-alpha blocked by TGF-beta). Tacrolimus 46-52 interferon gamma Homo sapiens 152-161 1320672-3 1992 Because recombinant human interferon gamma therapy enhances superoxide production in patients with chronic granulomatous disease, we sought to determine whether a similar strategy could reverse the osteopetrotic condition. Superoxides 60-70 interferon gamma Homo sapiens 26-42 1377705-6 1992 IFN gamma significantly reduced both hCG- and FSH-stimulated cAMP generation in granulosa cells. Cyclic AMP 61-65 interferon gamma Homo sapiens 0-9 1377705-9 1992 IFN gamma also reduced progesterone secretion in response to (Bu)2cAMP, suggesting that it also affects steps distal to cAMP generation. 2camp 65-70 interferon gamma Homo sapiens 0-9 1377705-9 1992 IFN gamma also reduced progesterone secretion in response to (Bu)2cAMP, suggesting that it also affects steps distal to cAMP generation. Cyclic AMP 66-70 interferon gamma Homo sapiens 0-9 1607677-3 1992 Glucocorticosteroids also inhibit IFN-gamma-induced HLA-DR expression, and similarities have been noted between the inhibition by trypsin inhibitors and by glucocorticosteroids. glucocorticosteroids 0-20 interferon gamma Homo sapiens 34-43 1607677-3 1992 Glucocorticosteroids also inhibit IFN-gamma-induced HLA-DR expression, and similarities have been noted between the inhibition by trypsin inhibitors and by glucocorticosteroids. glucocorticosteroids 156-176 interferon gamma Homo sapiens 34-43 1607677-4 1992 To assess the possibility that glucocorticosteroid inhibition of IFN-gamma-induced HLA-DR expression might be due to induction of an inhibitor of trypsin activity that is re-expression, we examined culture medium supernates (CM) of glucocorticosteroid-treated cells for HLA-DR- and trypsin-inhibitory activities. glucocorticosteroid 31-50 interferon gamma Homo sapiens 65-74 1607677-8 1992 We conclude, therefore, that the glucocorticosteroid inhibition of IFN-gamma-induced HLA-DR expression is by a mechanism other than secretion of a trypsin inhibitor. glucocorticosteroid 33-52 interferon gamma Homo sapiens 67-76 1376349-7 1992 Stimulation of spleen cells with the substituted oligonucleotide, A4a-AAC, induced production of significant amounts of IFN-alpha/beta and small amounts of IFN-gamma. Oligonucleotides 49-64 interferon gamma Homo sapiens 156-165 1591013-6 1992 Both interferon-gamma (IFN-gamma) and interferon-beta (IFN-beta) induced neopterin production and tryptophan degradation by AM with corresponding inhibition of intracellular replication by Chlamydia psittaci in AM, but IFN-gamma was a more potent inducer of these responses than IFN-beta. Neopterin 73-82 interferon gamma Homo sapiens 23-32 1591013-6 1992 Both interferon-gamma (IFN-gamma) and interferon-beta (IFN-beta) induced neopterin production and tryptophan degradation by AM with corresponding inhibition of intracellular replication by Chlamydia psittaci in AM, but IFN-gamma was a more potent inducer of these responses than IFN-beta. Tryptophan 98-108 interferon gamma Homo sapiens 23-32 1591013-10 1992 These studies suggest that IFN-gamma stimulates human AM to produce neopterin and degrade tryptophan more potently than IFN-beta, and that low concentrations of LPS can synergistically enhance such effects of interferons on tissue macrophage metabolism. Neopterin 68-77 interferon gamma Homo sapiens 27-36 1591013-10 1992 These studies suggest that IFN-gamma stimulates human AM to produce neopterin and degrade tryptophan more potently than IFN-beta, and that low concentrations of LPS can synergistically enhance such effects of interferons on tissue macrophage metabolism. Tryptophan 90-100 interferon gamma Homo sapiens 27-36 1606739-0 1992 Different lymphoid cell populations produce varied levels of neopterin, beta 2-microglobulin and soluble IL-2 receptor when stimulated with IL-2, interferon-gamma or tumour necrosis factor-alpha. Neopterin 61-70 interferon gamma Homo sapiens 146-194 1606739-5 1992 In vitro addition of interferon-gamma (IFN-gamma) or IL-2 stimulated peripheral blood mononuclear cells to produce neopterin, beta 2-microglobulin (beta 2-M) and soluble IL-2 receptor (sIL-2R). Neopterin 115-124 interferon gamma Homo sapiens 21-37 1606729-5 1992 Furthermore, rIFN-alpha and dexamethasone suppressed T cell binding to both endothelial cells and synovial cells stimulated by IFN-gamma, and also inhibited intercellular adhesion molecule-1 (ICAM-1) expression on both endothelial cells and synovial cells stimulated by IFN-gamma. Dexamethasone 28-41 interferon gamma Homo sapiens 127-136 1606739-5 1992 In vitro addition of interferon-gamma (IFN-gamma) or IL-2 stimulated peripheral blood mononuclear cells to produce neopterin, beta 2-microglobulin (beta 2-M) and soluble IL-2 receptor (sIL-2R). Neopterin 115-124 interferon gamma Homo sapiens 39-48 1606729-5 1992 Furthermore, rIFN-alpha and dexamethasone suppressed T cell binding to both endothelial cells and synovial cells stimulated by IFN-gamma, and also inhibited intercellular adhesion molecule-1 (ICAM-1) expression on both endothelial cells and synovial cells stimulated by IFN-gamma. Dexamethasone 28-41 interferon gamma Homo sapiens 270-279 1606740-0 1992 Neopterin release from human endothelial cells is triggered by interferon-gamma. Neopterin 0-9 interferon gamma Homo sapiens 63-79 1606740-3 1992 While IFN-gamma induced neopterin release from HUVEC in a time- and dose-dependent manner, all the other cytokines used had no effect on neopterin production. Neopterin 24-33 interferon gamma Homo sapiens 6-15 1350983-3 1992 The mean IL-2 production by PPD- or SK-specific TCL from both atopics and nonatopics was similar, whereas the mean IFN-gamma production by TCL derived from atopics was significantly lower. Triclosan 139-142 interferon gamma Homo sapiens 115-124 1587306-3 1992 The iron-mediated inhibition of the effects of IFN-gamma is fully reversed when iron is administered concomitantly with equimolar concentrations of the iron chelator deferoxamine. Iron 4-8 interferon gamma Homo sapiens 47-56 1587306-0 1992 Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1. Iron 0-4 interferon gamma Homo sapiens 15-31 1587306-3 1992 The iron-mediated inhibition of the effects of IFN-gamma is fully reversed when iron is administered concomitantly with equimolar concentrations of the iron chelator deferoxamine. Iron 80-84 interferon gamma Homo sapiens 47-56 1587306-1 1992 This investigation demonstrates that low concentrations (25 microM) of free and transferrin-bound iron reduce the efficiency of the interferon-gamma (IFN-gamma) signal in the human myelomonocytic cell line THP-1, as seen by decreased production of neopterin, reduced degradation of tryptophan, and impaired expression of major histocompatibility complex (MHC) class II antigens. Iron 98-102 interferon gamma Homo sapiens 132-148 1587306-3 1992 The iron-mediated inhibition of the effects of IFN-gamma is fully reversed when iron is administered concomitantly with equimolar concentrations of the iron chelator deferoxamine. Iron 80-84 interferon gamma Homo sapiens 47-56 1587306-1 1992 This investigation demonstrates that low concentrations (25 microM) of free and transferrin-bound iron reduce the efficiency of the interferon-gamma (IFN-gamma) signal in the human myelomonocytic cell line THP-1, as seen by decreased production of neopterin, reduced degradation of tryptophan, and impaired expression of major histocompatibility complex (MHC) class II antigens. Iron 98-102 interferon gamma Homo sapiens 150-159 1587306-1 1992 This investigation demonstrates that low concentrations (25 microM) of free and transferrin-bound iron reduce the efficiency of the interferon-gamma (IFN-gamma) signal in the human myelomonocytic cell line THP-1, as seen by decreased production of neopterin, reduced degradation of tryptophan, and impaired expression of major histocompatibility complex (MHC) class II antigens. Neopterin 248-257 interferon gamma Homo sapiens 150-159 1587306-1 1992 This investigation demonstrates that low concentrations (25 microM) of free and transferrin-bound iron reduce the efficiency of the interferon-gamma (IFN-gamma) signal in the human myelomonocytic cell line THP-1, as seen by decreased production of neopterin, reduced degradation of tryptophan, and impaired expression of major histocompatibility complex (MHC) class II antigens. Tryptophan 282-292 interferon gamma Homo sapiens 132-148 1587306-1 1992 This investigation demonstrates that low concentrations (25 microM) of free and transferrin-bound iron reduce the efficiency of the interferon-gamma (IFN-gamma) signal in the human myelomonocytic cell line THP-1, as seen by decreased production of neopterin, reduced degradation of tryptophan, and impaired expression of major histocompatibility complex (MHC) class II antigens. Tryptophan 282-292 interferon gamma Homo sapiens 150-159 1587306-3 1992 The iron-mediated inhibition of the effects of IFN-gamma is fully reversed when iron is administered concomitantly with equimolar concentrations of the iron chelator deferoxamine. Deferoxamine 166-178 interferon gamma Homo sapiens 47-56 1587306-4 1992 Furthermore, deferoxamine alone is even able to enhance the efficiency of the IFN-gamma signal. Deferoxamine 13-25 interferon gamma Homo sapiens 78-87 1587306-5 1992 Our data provide evidence that there is an inverse correlation between the intracellular amount of iron, which is not bound to ferritin, and the activity of the IFN-gamma signal. Iron 99-103 interferon gamma Homo sapiens 161-170 1587306-6 1992 This suggests that iron withholding by the immune cells in the course of inflammatory disorders may also contribute to the enhancement of the cytopathic effect of IFN-gamma. Iron 19-23 interferon gamma Homo sapiens 163-172 1321793-2 1992 Leukotriene B4 (LTB4) is a potent lipid inflammatory mediator which induces IL-2 and interferon-gamma (IFN-gamma) production from T cells. Leukotriene B4 0-14 interferon gamma Homo sapiens 85-101 1330900-0 1992 Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-alpha and IFN-gamma through a nitric oxide-dependent mechanism. Nitric Oxide 120-132 interferon gamma Homo sapiens 100-109 1330900-4 1992 Similarly, IFN-gamma triggered the production of nitric oxide (NO) by macrophages, whereas TNF-alpha was less effective, although it was also synergistic with IFN-gamma. Nitric Oxide 49-61 interferon gamma Homo sapiens 11-20 1321793-2 1992 Leukotriene B4 (LTB4) is a potent lipid inflammatory mediator which induces IL-2 and interferon-gamma (IFN-gamma) production from T cells. Leukotriene B4 0-14 interferon gamma Homo sapiens 103-112 1330900-5 1992 Both NO production and trypanocidal activity, but not superoxide (O2-) generation, induced in macrophages by TNF-alpha or IFN-gamma alone or in combination, were inhibited by N-monomethyl-L-arginine (N-MMLA), a competitive inhibitor of NO synthase activity. omega-N-Methylarginine 175-198 interferon gamma Homo sapiens 122-131 1427988-3 1992 Our results indicate that, despite the ability of IFN-gamma to increase both the generation of superoxide anion and hydrogen peroxide by phagocytic cells and the expression of the high-affinity 72-kDa Fc gamma RI, it is completely unable to increase NSC mediated either by neutrophils or monocytes. Superoxides 95-111 interferon gamma Homo sapiens 50-59 1427988-3 1992 Our results indicate that, despite the ability of IFN-gamma to increase both the generation of superoxide anion and hydrogen peroxide by phagocytic cells and the expression of the high-affinity 72-kDa Fc gamma RI, it is completely unable to increase NSC mediated either by neutrophils or monocytes. Hydrogen Peroxide 116-133 interferon gamma Homo sapiens 50-59 1616390-4 1992 Uptake of 50 microM glutamine was determined after a 12-hour incubation with varying doses (10 to 1000 U/mL) of tumor necrosis factor-alpha, interleukin-1, interleukin-6, interferon-gamma, and various combinations of these cytokines. Glutamine 20-29 interferon gamma Homo sapiens 171-187 1634256-5 1992 Immunosuppressive effects of culture supernatant (CS) of IFN-gamma-treated HGF were low and were completely abrogated by the addition of indomethacin. Indomethacin 137-149 interferon gamma Homo sapiens 57-66 1588290-10 1992 IFN-gamma enhanced the monocyte release of TNF-alpha by 3-7.5-fold (agonist dependent) when added to patient"s cells in vitro, and this could be suppressed by the in vitro addition of 10 micrograms/ml of thalidomide. Thalidomide 204-215 interferon gamma Homo sapiens 0-9 1621011-3 1992 The combined effect of IFN-gamma and TPA was blocked by the PKC inhibitor, suggesting that PKC plays an important role in the synergistic action of TPA and IFN-gamma on the inhibition of EGF binding to the cells. Tetradecanoylphorbol Acetate 37-40 interferon gamma Homo sapiens 156-165 1621011-3 1992 The combined effect of IFN-gamma and TPA was blocked by the PKC inhibitor, suggesting that PKC plays an important role in the synergistic action of TPA and IFN-gamma on the inhibition of EGF binding to the cells. Tetradecanoylphorbol Acetate 148-151 interferon gamma Homo sapiens 23-32 1621011-6 1992 No PKC activity, however, was observed in the WISH cells treated with both IFN-gamma and TPA for 24 h as well as with TPA alone for 24 h, indicating that IFN-gamma may synergize with the second mediator induced by PKC rather than PKC itself in the reduction of EGF binding to WISH cells. Tetradecanoylphorbol Acetate 89-92 interferon gamma Homo sapiens 154-163 1621011-7 1992 In addition, IFN-gamma showed the synergistic action with calcium ionophores on the reduction of EGF binding to the cells, suggesting that Ca2+ may be one of the second mediators which was induced by TPA and which cooperated with IFN-gamma. Calcium 58-65 interferon gamma Homo sapiens 230-239 1621011-7 1992 In addition, IFN-gamma showed the synergistic action with calcium ionophores on the reduction of EGF binding to the cells, suggesting that Ca2+ may be one of the second mediators which was induced by TPA and which cooperated with IFN-gamma. Tetradecanoylphorbol Acetate 200-203 interferon gamma Homo sapiens 13-22 1621011-7 1992 In addition, IFN-gamma showed the synergistic action with calcium ionophores on the reduction of EGF binding to the cells, suggesting that Ca2+ may be one of the second mediators which was induced by TPA and which cooperated with IFN-gamma. Tetradecanoylphorbol Acetate 200-203 interferon gamma Homo sapiens 230-239 1586705-0 1992 Interferon-gamma gene expression in unstimulated bone marrow mononuclear cells predicts a good response to cyclosporine therapy in aplastic anemia. Cyclosporine 107-119 interferon gamma Homo sapiens 0-16 1586705-6 1992 Of 13 patients who responded to CyA therapy and achieved transfusion-independence, IFN-gamma mRNA was detected in 12 patients, whereas the mRNA was only detectable in 3 of 10 patients refractory to CyA therapy (P = .003, Fisher"s exact test). Cyclosporine 32-35 interferon gamma Homo sapiens 83-92 1515211-8 1992 TNF and IFN gamma were tolerable after premedication with acetaminophen; however, no significant change in markers of human immunodeficiency virus infection was demonstrated. Acetaminophen 58-71 interferon gamma Homo sapiens 8-17 1627268-1 1992 Large amounts of D-erythro-neopterin, a pteridine derivative, are formed from guanosine triphosphate (GTP) by human macrophages upon stimulation with interferon-gamma. Neopterin 17-36 interferon gamma Homo sapiens 150-166 1534219-6 1992 Exposure to interferon-gamma substantially increased the accumulation of [13C6]QUIN in a dose- and time-dependent manner. [13c6]quin 73-83 interferon gamma Homo sapiens 12-28 1534219-8 1992 Macrophages stimulated with interferon-gamma may be an important source of accelerated L-tryptophan conversion into QUIN in inflammatory diseases. Tryptophan 87-99 interferon gamma Homo sapiens 28-44 1534219-8 1992 Macrophages stimulated with interferon-gamma may be an important source of accelerated L-tryptophan conversion into QUIN in inflammatory diseases. Quinolinic Acid 116-120 interferon gamma Homo sapiens 28-44 1627268-1 1992 Large amounts of D-erythro-neopterin, a pteridine derivative, are formed from guanosine triphosphate (GTP) by human macrophages upon stimulation with interferon-gamma. Pteridines 40-49 interferon gamma Homo sapiens 150-166 1627268-1 1992 Large amounts of D-erythro-neopterin, a pteridine derivative, are formed from guanosine triphosphate (GTP) by human macrophages upon stimulation with interferon-gamma. Guanosine Triphosphate 78-100 interferon gamma Homo sapiens 150-166 1627268-1 1992 Large amounts of D-erythro-neopterin, a pteridine derivative, are formed from guanosine triphosphate (GTP) by human macrophages upon stimulation with interferon-gamma. Guanosine Triphosphate 102-105 interferon gamma Homo sapiens 150-166 1576656-9 1992 SEA- or staphylococcal enterotoxin B-induced production of IFN-gamma is inhibited when highly purified monocytes pretreated with CKS-17 are cocultured with highly purified T lymphocytes. Boron 35-36 interferon gamma Homo sapiens 59-68 1568222-1 1992 In HL-60 and ML-3 human myeloid cell lines, gamma-interferon (IFN-gamma) and/or tumor necrosis factor (TNF) induce synergistic accumulation of transcripts of the genes encoding the heavy chain (gp91-phox) of cytochrome b558 and the cytosolic factors p47-phox and p67-phox, components of the superoxide-generating NADPH oxidase system. Superoxides 291-301 interferon gamma Homo sapiens 62-71 1576656-9 1992 SEA- or staphylococcal enterotoxin B-induced production of IFN-gamma is inhibited when highly purified monocytes pretreated with CKS-17 are cocultured with highly purified T lymphocytes. CKS 17 129-135 interferon gamma Homo sapiens 59-68 1498255-1 1992 Serum concentrations of tryptophan (TRP) and kynurenine (KYN) were determined in renal allograft recipients (RAR) as an index of interferon-gamma-induced, indoleamine-dioxygenase-catalysed TRP degradation. Tryptophan 189-192 interferon gamma Homo sapiens 129-145 1576656-10 1992 Thus, CKS-17 induces dramatic clustering of cells apparently by inducing alterations of monocytes but not lymphocytes, suggesting that CKS-17 may interfere with the capacity of monocytes to facilitate production of IFN-gamma by T lymphocytes. CKS 17 6-12 interferon gamma Homo sapiens 215-224 1628893-2 1992 When human leukaemia THP-1 and PL-21 cells were pretreated with phorbol ester, IFN-gamma-dependent induction of MHC class II gene was markedly enhanced. Phorbol Esters 64-77 interferon gamma Homo sapiens 79-88 1379284-3 1992 Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Poly I 71-78 interferon gamma Homo sapiens 24-33 1379284-3 1992 Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Poly C 79-86 interferon gamma Homo sapiens 24-33 1379284-3 1992 Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Poly I 173-180 interferon gamma Homo sapiens 24-33 1573267-7 1992 Thioglycollate-elicited peritoneal exudate macrophages incubated with native doublet MIP 1-secreted bioactive TNF and IL-6, as well as immunoreactive IL-1 alpha, and these effects were enhanced significantly when the cells were costimulated with IFN-gamma. Thioglycolates 0-14 interferon gamma Homo sapiens 246-255 1379284-3 1992 Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Poly C 79-85 interferon gamma Homo sapiens 24-33 1583907-0 1992 Ethanol inhibits interferon-gamma secretion by human peripheral lymphocytes. Ethanol 0-7 interferon gamma Homo sapiens 17-33 1392402-3 1992 The potentiation of cytotoxicity by CDDP was also observed with PBM treated with recombinant interferon-gamma (rIFN-gamma). Cisplatin 36-40 interferon gamma Homo sapiens 93-109 1392402-3 1992 The potentiation of cytotoxicity by CDDP was also observed with PBM treated with recombinant interferon-gamma (rIFN-gamma). pbm 64-67 interferon gamma Homo sapiens 93-109 1555249-0 1992 Hexadecylphosphocholine induces interferon-gamma secretion and expression of GM-CSF mRNA in human mononuclear cells. miltefosine 0-23 interferon gamma Homo sapiens 32-48 1555249-1 1992 The effects of hexadecylphosphocholine (HePC) on secretion of interferon-gamma (IFN-gamma) and steady-state levels of IFN-gamma and GM-CSF mRNA were studied in human mononuclear cells. miltefosine 40-44 interferon gamma Homo sapiens 62-78 1583907-3 1992 Using human peripheral blood mononuclear cells we could demonstrate in vitro for the first time that even low ethanol concentrations of 6 and 12.5 mM significantly inhibit spontaneous and mitogen-induced secretion of interferon-gamma. Ethanol 110-117 interferon gamma Homo sapiens 217-233 1350916-2 1992 In this report it is shown that BA can activate human CD3+ T cells to secrete interferon-gamma (IFN gamma). Barium 32-34 interferon gamma Homo sapiens 78-94 1560204-9 1992 Guanosine 5"-[gamma-thio]triphosphate equilibrium binding demonstrated an increased number of G proteins coupled to formyl peptide receptors on IFN-M. We conclude that IFN-gamma increases expression of both formyl peptide receptors and G proteins coupled to these receptors, thereby enhancing FMLP-stimulated transmembrane signaling. Guanosine 5'-O-(3-Thiotriphosphate) 0-37 interferon gamma Homo sapiens 168-177 1551894-4 1992 Induction of LAP mRNA is a secondary response to IFN-gamma, blocked by inhibition of protein synthesis with cycloheximide. Cycloheximide 108-121 interferon gamma Homo sapiens 49-58 1350916-2 1992 In this report it is shown that BA can activate human CD3+ T cells to secrete interferon-gamma (IFN gamma). Barium 32-34 interferon gamma Homo sapiens 96-105 1350916-5 1992 BA elicited IFN gamma from CD4+ and CD8+ T cells, although CD4+ T cells secrete significantly more (p less than 0.05) IFN gamma than CD8+ T cells. Barium 0-2 interferon gamma Homo sapiens 12-21 1350916-6 1992 The ability of BA to elicit IFN gamma from human T cells was inhibited in the presence of anti-Tac, suggesting that BA also induces IL-2 secretion and that IL-2 is involved in BA-mediated IFN gamma secretion. Barium 15-17 interferon gamma Homo sapiens 28-37 1350916-6 1992 The ability of BA to elicit IFN gamma from human T cells was inhibited in the presence of anti-Tac, suggesting that BA also induces IL-2 secretion and that IL-2 is involved in BA-mediated IFN gamma secretion. Barium 15-17 interferon gamma Homo sapiens 188-197 1350916-8 1992 Exogenous IL-2 acted synergistically with BA to enhance IFN gamma secretion, suggesting that the amount of IL-2 released by BA alone was insufficient for optimal IFN gamma release. Barium 42-44 interferon gamma Homo sapiens 56-65 1350916-10 1992 These data indicate that BA is capable not only of activating human B cells but can also induce T cells, probably of the TH1 phenotype, to secrete IFN gamma. Barium 25-27 interferon gamma Homo sapiens 147-156 1554224-3 1992 Upon PMA stimulation, they displayed a better preserved ability to produce superoxide anion and to respond to IFN-gamma priming by increased superoxide anion production. Superoxides 141-157 interferon gamma Homo sapiens 110-119 1511700-10 1992 This study shows that IFN-gamma regulates cell behavior in three-dimensional collagen matrices: (i) it decreases protein and specifically glycosaminoglycan synthesis in scleroderma fibroblasts, (ii) it modulates the interactions between cells and matrix that lead to the retraction of the lattice. Glycosaminoglycans 138-155 interferon gamma Homo sapiens 22-31 1612635-5 1992 In vitro, interferon-gamma induces the formation of neopterin in human monocytes/macrophages. Neopterin 52-61 interferon gamma Homo sapiens 10-26 1612635-6 1992 Also the degradation of tryptophan via the kynurenine pathway is induced by interferon-gamma. Tryptophan 24-34 interferon gamma Homo sapiens 76-92 1612635-6 1992 Also the degradation of tryptophan via the kynurenine pathway is induced by interferon-gamma. Kynurenine 43-53 interferon gamma Homo sapiens 76-92 1556191-10 1992 Finally, IFN gamma treatment reduced intracellular cholesteryl ester accumulation and inhibited the development of foam cells in the cultures. Cholesterol Esters 51-68 interferon gamma Homo sapiens 9-18 1350568-3 1992 HL-60 cells acquired the ability to express such surface molecules by stimulation with IFN-gamma when the cells were pretreated with 1,25-dihydroxyvitamin D3 (Vit D). Calcitriol 133-157 interferon gamma Homo sapiens 87-96 1503609-1 1992 Cyclosporin A (CsA) is a potent inhibitor of cytokine (IL-2-IL-6, IFN gamma) production by CD4+ T lymphocytes stimulated via the T cell antigen receptor pathway. Cyclosporine 0-13 interferon gamma Homo sapiens 66-75 1503609-1 1992 Cyclosporin A (CsA) is a potent inhibitor of cytokine (IL-2-IL-6, IFN gamma) production by CD4+ T lymphocytes stimulated via the T cell antigen receptor pathway. Cyclosporine 15-18 interferon gamma Homo sapiens 66-75 1532000-2 1992 PBMC from two normal individuals, which were stimulated with PPD and then cultured in IL-2 alone, developed into PPD-specific TCL and TCC able to produce IFN-gamma and IL-2 but not IL-4 and IL-5 (Th1-like). Triclosan 126-129 interferon gamma Homo sapiens 154-163 1365019-0 1992 Interferon-gamma potentiates the antitumor effect of cyclosporine-induced autoimmunity. Cyclosporine 53-65 interferon gamma Homo sapiens 0-16 1365019-5 1992 Since many hematopoietic malignancies express variable levels of class II molecules, we hypothesized that the adjuvant use of interferon-gamma (IFN-gamma) with CsA-induced autoimmunity after autologous/syngeneic BMT may upregulate class II antigens on residual tumor cells and make them more susceptible to attack by the Ia-reactive cells of CsA-induced AIS. Cyclosporine 160-163 interferon gamma Homo sapiens 126-142 1365019-5 1992 Since many hematopoietic malignancies express variable levels of class II molecules, we hypothesized that the adjuvant use of interferon-gamma (IFN-gamma) with CsA-induced autoimmunity after autologous/syngeneic BMT may upregulate class II antigens on residual tumor cells and make them more susceptible to attack by the Ia-reactive cells of CsA-induced AIS. Cyclosporine 160-163 interferon gamma Homo sapiens 144-153 1532000-2 1992 PBMC from two normal individuals, which were stimulated with PPD and then cultured in IL-2 alone, developed into PPD-specific TCL and TCC able to produce IFN-gamma and IL-2 but not IL-4 and IL-5 (Th1-like). Triclocarban 134-137 interferon gamma Homo sapiens 154-163 1365019-5 1992 Since many hematopoietic malignancies express variable levels of class II molecules, we hypothesized that the adjuvant use of interferon-gamma (IFN-gamma) with CsA-induced autoimmunity after autologous/syngeneic BMT may upregulate class II antigens on residual tumor cells and make them more susceptible to attack by the Ia-reactive cells of CsA-induced AIS. Cyclosporine 342-345 interferon gamma Homo sapiens 126-142 1365019-5 1992 Since many hematopoietic malignancies express variable levels of class II molecules, we hypothesized that the adjuvant use of interferon-gamma (IFN-gamma) with CsA-induced autoimmunity after autologous/syngeneic BMT may upregulate class II antigens on residual tumor cells and make them more susceptible to attack by the Ia-reactive cells of CsA-induced AIS. Cyclosporine 342-345 interferon gamma Homo sapiens 144-153 1532000-4 1992 In contrast, the addition of IL-4 resulted in the development of PPD-specific TCL and TCC able to produce not only IFN-gamma and IL-2 but also IL-4 and IL-5. Triclosan 78-81 interferon gamma Homo sapiens 115-124 1532000-4 1992 In contrast, the addition of IL-4 resulted in the development of PPD-specific TCL and TCC able to produce not only IFN-gamma and IL-2 but also IL-4 and IL-5. Triclocarban 86-89 interferon gamma Homo sapiens 115-124 1532000-5 1992 PBMC from one atopic Der p I-sensitive patient, which were stimulated with Der p I and then cultured in IL-2 alone, developed into Der p I-specific TCL and TCC able to produce IL-5 and large amounts of IL-4 but no IFN-gamma (Th2-like). Triclocarban 156-159 interferon gamma Homo sapiens 214-223 1532000-5 1992 PBMC from one atopic Der p I-sensitive patient, which were stimulated with Der p I and then cultured in IL-2 alone, developed into Der p I-specific TCL and TCC able to produce IL-5 and large amounts of IL-4 but no IFN-gamma (Th2-like). Triclosan 148-151 interferon gamma Homo sapiens 214-223 1532000-6 1992 The addition in bulk cultures, before cloning, of either IFN-gamma or anti-IL-4 antibody markedly inhibited the development of Der p I-specific T cells into IL-4- and IL-5-producing TCL. Triclosan 182-185 interferon gamma Homo sapiens 57-66 1409545-2 1992 We used a randomized oligonucleotide to mutagenize a synthetic human IFN gamma gene, then screened the resulting mutants produced in Escherichia coli for proteins with altered biological activity. Oligonucleotides 21-36 interferon gamma Homo sapiens 69-78 1557611-2 1992 Interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) decreased the level of ecto-5"-NT activity on BMC whereas prostaglandin E2 (PGE2) increased the ecto-5"-NT level. bmc 100-103 interferon gamma Homo sapiens 25-41 1557611-2 1992 Interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) decreased the level of ecto-5"-NT activity on BMC whereas prostaglandin E2 (PGE2) increased the ecto-5"-NT level. bmc 100-103 interferon gamma Homo sapiens 43-52 1557656-7 1992 Interferon gamma interacts with 5-FU in H630 colon cancer cells at the level of thymidylate synthase and enhances cytotoxicity of 5-FU by eliminating the 5-FU-induced acute overexpression of the target enzyme. Fluorouracil 32-36 interferon gamma Homo sapiens 0-16 1557656-7 1992 Interferon gamma interacts with 5-FU in H630 colon cancer cells at the level of thymidylate synthase and enhances cytotoxicity of 5-FU by eliminating the 5-FU-induced acute overexpression of the target enzyme. Fluorouracil 130-134 interferon gamma Homo sapiens 0-16 1557656-7 1992 Interferon gamma interacts with 5-FU in H630 colon cancer cells at the level of thymidylate synthase and enhances cytotoxicity of 5-FU by eliminating the 5-FU-induced acute overexpression of the target enzyme. Fluorouracil 130-134 interferon gamma Homo sapiens 0-16 1409546-5 1992 Sequencing the plasmid DNA encoding this mutant protein showed that the histidine at position 111 of native human IFN gamma is changed to aspartic acid (IFN gamma/H111D). Histidine 72-81 interferon gamma Homo sapiens 114-123 1409546-5 1992 Sequencing the plasmid DNA encoding this mutant protein showed that the histidine at position 111 of native human IFN gamma is changed to aspartic acid (IFN gamma/H111D). Histidine 72-81 interferon gamma Homo sapiens 114-119 1409546-5 1992 Sequencing the plasmid DNA encoding this mutant protein showed that the histidine at position 111 of native human IFN gamma is changed to aspartic acid (IFN gamma/H111D). Aspartic Acid 138-151 interferon gamma Homo sapiens 114-123 1409546-5 1992 Sequencing the plasmid DNA encoding this mutant protein showed that the histidine at position 111 of native human IFN gamma is changed to aspartic acid (IFN gamma/H111D). Aspartic Acid 138-151 interferon gamma Homo sapiens 114-119 1379978-1 1992 The binding of 125I-labelled recombinant human TNF alpha and IFN gamma to isolated human blood alpha 2-macroglobulin has been investigated using molecular sieving procedures and non-denaturing PA gel electrophoresis in combination with autoradiography. Iodine-125 15-19 interferon gamma Homo sapiens 61-70 1541147-7 1992 The release of interferon gamma by BAL cells could be further stimulated with concanavalin A and suppressed by cyclosporine. Cyclosporine 111-123 interferon gamma Homo sapiens 15-31 1547819-11 1992 After the fourth administration of PEG IL-2, the peak level of IFN-gamma was 2 to 20 times higher than after the first, while the peak level of IL-6 did not change in a consistent direction. Polyethylene Glycols 35-38 interferon gamma Homo sapiens 63-72 1379978-3 1992 PAGE/SDS gel investigations indicated that TNF alpha bound non-covalently while the IFN gamma interaction was covalent in nature. Sodium Dodecyl Sulfate 5-8 interferon gamma Homo sapiens 84-93 1541678-1 1992 An interferon-gamma, tumor necrosis factor, and interleukin-1-inducible, high-output pathway synthesizing nitric oxide (NO) from L-arginine was recently identified in rodents. Nitric Oxide 106-118 interferon gamma Homo sapiens 3-19 1541678-1 1992 An interferon-gamma, tumor necrosis factor, and interleukin-1-inducible, high-output pathway synthesizing nitric oxide (NO) from L-arginine was recently identified in rodents. Arginine 129-139 interferon gamma Homo sapiens 3-19 1740495-2 1992 Furthermore, it has been reported that interferon-gamma-induced DR-positive thyrocytes in vitro secrete less thyroid hormone in response to TSH stimulation compared with DR-negative ones. Thyrotropin 140-143 interferon gamma Homo sapiens 39-55 1311348-11 1992 Treatment of IFN-gamma-stimulated eosinophils with phosphatidylinositol-specific phospholipase C reduced FcRIII expression, suggesting that, like neutrophils, eosinophils express the phosphatidylinositol glycan-linked form of this receptor. Phosphatidylinositols 51-71 interferon gamma Homo sapiens 13-22 1311348-11 1992 Treatment of IFN-gamma-stimulated eosinophils with phosphatidylinositol-specific phospholipase C reduced FcRIII expression, suggesting that, like neutrophils, eosinophils express the phosphatidylinositol glycan-linked form of this receptor. Phosphatidylinositols 183-203 interferon gamma Homo sapiens 13-22 1311348-11 1992 Treatment of IFN-gamma-stimulated eosinophils with phosphatidylinositol-specific phospholipase C reduced FcRIII expression, suggesting that, like neutrophils, eosinophils express the phosphatidylinositol glycan-linked form of this receptor. Polysaccharides 204-210 interferon gamma Homo sapiens 13-22 1311348-12 1992 Therefore, this study demonstrates that IFN-gamma-treated eosinophils express a functionally active, phosphatidylinositol glycan-anchored form of FcRIII. Glycosylphosphatidylinositols 101-128 interferon gamma Homo sapiens 40-49 1372867-1 1992 Activation of J774-macrophages with lipopolysaccharide (LPS) or LPS and recombinant interferon-gamma (IFN-gamma) induced nitric oxide (NO) synthase activity, as measured by the production of nitrite and citrulline. Nitric Oxide 121-133 interferon gamma Homo sapiens 84-111 1592362-6 1992 The significant reduction of the desired antiproliferative activity of ara-C by the three interferons was reproduced in liquid suspension cultures of K562 cells on day 4 in the following order: IFN-gamma greater than IFN-beta greater than IFN-alpha. Cytarabine 71-76 interferon gamma Homo sapiens 194-203 1310709-0 1992 Differential effects of prostaglandins on macrophage activation induced by calcium ionophore A23187 or IFN-gamma. Prostaglandins 24-38 interferon gamma Homo sapiens 103-112 1310709-1 1992 Calcium ionophore A23187 can mimic IFN-gamma-induced macrophage activation for intracellular Leishmania killing and secretion of L-arginine-derived nitrite. Calcium 0-7 interferon gamma Homo sapiens 35-44 1310709-1 1992 Calcium ionophore A23187 can mimic IFN-gamma-induced macrophage activation for intracellular Leishmania killing and secretion of L-arginine-derived nitrite. Calcimycin 18-24 interferon gamma Homo sapiens 35-44 1310709-1 1992 Calcium ionophore A23187 can mimic IFN-gamma-induced macrophage activation for intracellular Leishmania killing and secretion of L-arginine-derived nitrite. l-arginine-derived nitrite 129-155 interferon gamma Homo sapiens 35-44 1310709-3 1992 Macrophages exposed to A23187 or IFN-gamma in the presence of LPS and FCS secreted significant amounts of PGE2 independently of the presence of L-arginine in the incubation medium. Dinoprostone 106-110 interferon gamma Homo sapiens 33-42 1310709-3 1992 Macrophages exposed to A23187 or IFN-gamma in the presence of LPS and FCS secreted significant amounts of PGE2 independently of the presence of L-arginine in the incubation medium. Arginine 144-154 interferon gamma Homo sapiens 33-42 1310709-5 1992 The addition of exogenous PGE2, of agents increasing PGE2 production such as arachidonic acid and colchicine, or of an analogue of cAMP, dibutyryl cAMP inhibited A23187 + LPS-induced activation whereas that mediated by IFN-gamma + LPS remained unimpaired. Dinoprostone 26-30 interferon gamma Homo sapiens 219-228 1310709-5 1992 The addition of exogenous PGE2, of agents increasing PGE2 production such as arachidonic acid and colchicine, or of an analogue of cAMP, dibutyryl cAMP inhibited A23187 + LPS-induced activation whereas that mediated by IFN-gamma + LPS remained unimpaired. Calcimycin 162-168 interferon gamma Homo sapiens 219-228 1372867-1 1992 Activation of J774-macrophages with lipopolysaccharide (LPS) or LPS and recombinant interferon-gamma (IFN-gamma) induced nitric oxide (NO) synthase activity, as measured by the production of nitrite and citrulline. Nitrites 191-198 interferon gamma Homo sapiens 84-111 1372867-1 1992 Activation of J774-macrophages with lipopolysaccharide (LPS) or LPS and recombinant interferon-gamma (IFN-gamma) induced nitric oxide (NO) synthase activity, as measured by the production of nitrite and citrulline. Citrulline 203-213 interferon gamma Homo sapiens 84-111 1632490-5 1992 Thus, interferon-gamma-treated human peripheral blood mononuclear cells formed and released significant amounts of 3-hydroxyanthranilic acid into the culture medium and mouse liver nuclear fraction possessed high "cinnabarinic acid synthase" activity. 3-Hydroxyanthranilic Acid 115-140 interferon gamma Homo sapiens 6-22 1531037-1 1992 We recently showed that mRNA levels coding the high-affinity Fc gamma receptor for IgG (Fc gamma R-I, CD64) and two of the components of the phagocytic superoxide anion-generating system--the heavy-chain subunit of cytochrome b558 (gp91-phox) and the 47-Kd cytosolic factor (p47-phox)--are modulated by interferon gamma (IFN-gamma). Superoxides 152-168 interferon gamma Homo sapiens 303-330 1551697-3 1992 Treatment with 1,25-(OH)2D3 markedly inhibited both culture and IFN-gamma-enhanced HLA-DR but not HLA-ABC (MHC class I). Calcitriol 15-27 interferon gamma Homo sapiens 64-73 18600949-0 1992 Glucose-limited chemostat culture of Chinese hamster ovary cells producing recombinant human interferon-gamma. Glucose 0-7 interferon gamma Homo sapiens 93-109 18600949-1 1992 A Chinese hamster ovary (CHO) cell line expressing recombinant human interferon-gamma (IFN-gamma) was grown under glucose limitation in a chemostate at a constant dilution rate of 0.015 h(-1) with glucose feed concentrations of 2.75 mM and 4.25 mM. Glucose 197-204 interferon gamma Homo sapiens 69-85 1551697-7 1992 Northern analysis also demonstrated that 1,25-(OH)2D3 treatment markedly decreased both expression of culture-enhanced and IFN-gamma-enhanced HLA-DR beta chain messenger RNA (mRNA) in monocyte-enriched populations. Calcitriol 41-53 interferon gamma Homo sapiens 123-132 1370514-8 1992 Stimulation with Con A also induced very low or no measurable levels of IL-2 and IFN-gamma, whereas activation with TPA and the calcium ionophore A23187 resulted in the production of high levels of IL-4, IL-5, IL-2, and IFN-gamma. Tetradecanoylphorbol Acetate 116-119 interferon gamma Homo sapiens 220-229 1370514-8 1992 Stimulation with Con A also induced very low or no measurable levels of IL-2 and IFN-gamma, whereas activation with TPA and the calcium ionophore A23187 resulted in the production of high levels of IL-4, IL-5, IL-2, and IFN-gamma. Calcium 128-135 interferon gamma Homo sapiens 220-229 1370514-8 1992 Stimulation with Con A also induced very low or no measurable levels of IL-2 and IFN-gamma, whereas activation with TPA and the calcium ionophore A23187 resulted in the production of high levels of IL-4, IL-5, IL-2, and IFN-gamma. Calcimycin 146-152 interferon gamma Homo sapiens 220-229 1374108-4 1992 Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis of covalently cross-linked 32P-labeled IFN-gamma and its receptor is consistent with a molecular mass of approximately 99 kD. Sodium Dodecyl Sulfate 0-22 interferon gamma Homo sapiens 117-126 1537350-5 1992 In vitro incubation of neutrophils with recombinant human interferon-gamma (rIFN-gamma) showed an increase in oxygen consumption, but no effect on the expression of the LeuCAMs, or the beta chain mRNA. Oxygen 110-116 interferon gamma Homo sapiens 58-74 1374108-4 1992 Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis of covalently cross-linked 32P-labeled IFN-gamma and its receptor is consistent with a molecular mass of approximately 99 kD. Sodium Dodecyl Sulfate 59-62 interferon gamma Homo sapiens 117-126 1374108-4 1992 Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis of covalently cross-linked 32P-labeled IFN-gamma and its receptor is consistent with a molecular mass of approximately 99 kD. polyacrylamide 23-37 interferon gamma Homo sapiens 117-126 1374108-4 1992 Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis of covalently cross-linked 32P-labeled IFN-gamma and its receptor is consistent with a molecular mass of approximately 99 kD. Phosphorus-32 105-108 interferon gamma Homo sapiens 117-126 1370436-0 1992 Biphasic effect of cAMP-elevating agents on ICAM-1 expression stimulated by retinoic acid and interferon gamma. Cyclic AMP 19-23 interferon gamma Homo sapiens 94-110 1431547-1 1992 The production of arachidonic acid metabolites by the HL60, ML3, and U937 human phagocyte cell lines was determined after incubation with interferon-gamma (IFN-gamma, 500 U/ml) or vehicle for 4 days. Arachidonic Acid 18-34 interferon gamma Homo sapiens 138-154 1431547-1 1992 The production of arachidonic acid metabolites by the HL60, ML3, and U937 human phagocyte cell lines was determined after incubation with interferon-gamma (IFN-gamma, 500 U/ml) or vehicle for 4 days. Arachidonic Acid 18-34 interferon gamma Homo sapiens 156-165 1431547-4 1992 In response to 10 microM calcium ionophore A23187 incubation (30 min), undifferentiated and IFN-gamma-differentiated HL60 cells formed both cyclooxygenase products (thromboxane and prostaglandins) and lipoxygenase products (leukotrienes and hydroxyeicosatetraenoic acids). Calcium 25-32 interferon gamma Homo sapiens 92-101 1431547-4 1992 In response to 10 microM calcium ionophore A23187 incubation (30 min), undifferentiated and IFN-gamma-differentiated HL60 cells formed both cyclooxygenase products (thromboxane and prostaglandins) and lipoxygenase products (leukotrienes and hydroxyeicosatetraenoic acids). Calcimycin 43-49 interferon gamma Homo sapiens 92-101 1431547-4 1992 In response to 10 microM calcium ionophore A23187 incubation (30 min), undifferentiated and IFN-gamma-differentiated HL60 cells formed both cyclooxygenase products (thromboxane and prostaglandins) and lipoxygenase products (leukotrienes and hydroxyeicosatetraenoic acids). Thromboxanes 165-176 interferon gamma Homo sapiens 92-101 1431547-4 1992 In response to 10 microM calcium ionophore A23187 incubation (30 min), undifferentiated and IFN-gamma-differentiated HL60 cells formed both cyclooxygenase products (thromboxane and prostaglandins) and lipoxygenase products (leukotrienes and hydroxyeicosatetraenoic acids). Prostaglandins 181-195 interferon gamma Homo sapiens 92-101 1431547-4 1992 In response to 10 microM calcium ionophore A23187 incubation (30 min), undifferentiated and IFN-gamma-differentiated HL60 cells formed both cyclooxygenase products (thromboxane and prostaglandins) and lipoxygenase products (leukotrienes and hydroxyeicosatetraenoic acids). Leukotrienes 224-236 interferon gamma Homo sapiens 92-101 1431547-4 1992 In response to 10 microM calcium ionophore A23187 incubation (30 min), undifferentiated and IFN-gamma-differentiated HL60 cells formed both cyclooxygenase products (thromboxane and prostaglandins) and lipoxygenase products (leukotrienes and hydroxyeicosatetraenoic acids). Hydroxyeicosatetraenoic Acids 241-270 interferon gamma Homo sapiens 92-101 1370436-5 1992 Indeed, 24 hr after treatment with cAMP-elevating agents, both the retinoic-acid- and the IFN-gamma-induced ICAM-1 expression were inhibited by 60 to 80%, with a maximal 90 to 100% inhibition 72 hr post treatment. Cyclic AMP 35-39 interferon gamma Homo sapiens 90-99 1370436-10 1992 These results were also correlated with an in vitro activation of adenylyl cyclase activity by retinoic acid and inhibition of this activity by IFN-gamma, in a dose-dependent and a GTP-dependent manner. Guanosine Triphosphate 181-184 interferon gamma Homo sapiens 144-153 1370436-11 1992 Our results suggest that the suppression of IFN-gamma-induced ICAM-1 expression, obtained upon pre-treatment with cAMP-elevating agents, is due to direct antagonism with IFN-gamma action on adenylyl cyclase. Cyclic AMP 114-118 interferon gamma Homo sapiens 44-53 1370436-11 1992 Our results suggest that the suppression of IFN-gamma-induced ICAM-1 expression, obtained upon pre-treatment with cAMP-elevating agents, is due to direct antagonism with IFN-gamma action on adenylyl cyclase. Cyclic AMP 114-118 interferon gamma Homo sapiens 170-179 1284366-5 1992 We have discovered that the seleno-organic compounds induce interferon gamma (IFN-gamma), IFN-alpha, tumor necrosis factor alpha (TNF-alpha) and other cytokines in human peripheral blood leukocytes (PBL). seleno-organic compounds 28-52 interferon gamma Homo sapiens 60-87 1540976-5 1992 Analysis of the supernatant culture medium after 72 h incubation of PBMC and their highly purified subpopulations demonstrated that CySF-L2 induced release of IFN gamma from CD3+T cells and CD56+CD3- NK cells and of TNF alpha and prostaglandin E2 from monocytes. Dinoprostone 230-246 interferon gamma Homo sapiens 159-168 1300989-4 1992 We described a production of IFN-gamma and TNF-alpha by various subsets of PBL stimulated with 2-phenyl-1,2-benzisoselenazol-3(2H)-one (ebselen) or bis [2-(N-phenyl-carbamoyl)]phenyl diselenide. ebselen 95-134 interferon gamma Homo sapiens 29-38 1300989-4 1992 We described a production of IFN-gamma and TNF-alpha by various subsets of PBL stimulated with 2-phenyl-1,2-benzisoselenazol-3(2H)-one (ebselen) or bis [2-(N-phenyl-carbamoyl)]phenyl diselenide. ebselen 136-143 interferon gamma Homo sapiens 29-38 1300989-4 1992 We described a production of IFN-gamma and TNF-alpha by various subsets of PBL stimulated with 2-phenyl-1,2-benzisoselenazol-3(2H)-one (ebselen) or bis [2-(N-phenyl-carbamoyl)]phenyl diselenide. bis [2-(n-phenyl-carbamoyl)]phenyl diselenide 148-193 interferon gamma Homo sapiens 29-38 1299346-4 1992 1,25-(OH)2 D3 inhibits lymphocyte proliferation, immunoglobulin production and the release of cytokines including interleukin-2 (IL-2) and interferon gamma (IFN gamma) by mitogen driven blood mononuclear cells (MNC). Calcitriol 0-13 interferon gamma Homo sapiens 139-155 1299346-4 1992 1,25-(OH)2 D3 inhibits lymphocyte proliferation, immunoglobulin production and the release of cytokines including interleukin-2 (IL-2) and interferon gamma (IFN gamma) by mitogen driven blood mononuclear cells (MNC). Calcitriol 0-13 interferon gamma Homo sapiens 157-166 1532770-0 1992 Nicotinamide and 3-aminobenzamide inhibit recombinant human interferon-gamma-induced HLA-DR antigen expression, but not HLA-A, B, C antigen expression, on cultured human thyroid cells. Niacinamide 0-12 interferon gamma Homo sapiens 60-76 1532770-0 1992 Nicotinamide and 3-aminobenzamide inhibit recombinant human interferon-gamma-induced HLA-DR antigen expression, but not HLA-A, B, C antigen expression, on cultured human thyroid cells. 3-aminobenzamide 17-33 interferon gamma Homo sapiens 60-76 1532770-1 1992 OBJECTIVE: We wished to investigate the effects of nicotinamide and 3-aminobenzamide, well known as inhibitors of poly(ADP ribose) synthetase, on interferon-gamma-induced HLA-DR antigen expression using cultured human thyroid cells from patients with Graves" disease. Niacinamide 51-63 interferon gamma Homo sapiens 146-162 1478011-2 1992 A clone of U937 cells was selected which expressed Fc receptor I (Fc gamma RI) and which, after incubation with IFN-gamma for 72 h, was capable of generating high levels of lucigenin-enhanced CL. 10,10'-dimethyl-9,9'-biacridinium 173-182 interferon gamma Homo sapiens 112-121 1532770-1 1992 OBJECTIVE: We wished to investigate the effects of nicotinamide and 3-aminobenzamide, well known as inhibitors of poly(ADP ribose) synthetase, on interferon-gamma-induced HLA-DR antigen expression using cultured human thyroid cells from patients with Graves" disease. 3-aminobenzamide 68-84 interferon gamma Homo sapiens 146-162 1489521-4 1992 In recent years it was shown that production and release of neopterin is inducible in human monocytes/macrophages by interferon gamma. Neopterin 60-69 interferon gamma Homo sapiens 117-133 1347751-0 1992 Inhibitory effects of nicotinamide on recombinant human interferon-gamma-induced intercellular adhesion molecule-1 (ICAM-1) and HLA-DR antigen expression on cultured human endothelial cells. Niacinamide 22-34 interferon gamma Homo sapiens 56-72 1370149-10 1992 However, indomethacin, a well known inhibitor of prostaglandin synthesis, prevented the increase in lipolysis induced by TNF, IL-1, IFN alpha, IFN beta, or IFN gamma. Indomethacin 9-21 interferon gamma Homo sapiens 156-165 1740279-0 1992 Salicylates used in inflammatory bowel disease and colchicine impair interferon-gamma induced HLA-DR expression. Salicylates 0-11 interferon gamma Homo sapiens 69-85 1740279-0 1992 Salicylates used in inflammatory bowel disease and colchicine impair interferon-gamma induced HLA-DR expression. Colchicine 51-61 interferon gamma Homo sapiens 69-85 1740279-2 1992 The effect of drugs used in the treatment of inflammatory bowel disease and colchicine on interferon-gamma (IFN-gamma) induced DR expression has been investigated. Colchicine 76-86 interferon gamma Homo sapiens 90-106 1740279-2 1992 The effect of drugs used in the treatment of inflammatory bowel disease and colchicine on interferon-gamma (IFN-gamma) induced DR expression has been investigated. Colchicine 76-86 interferon gamma Homo sapiens 108-117 1740279-6 1992 10(-2) M 5ASA reduced DR expression induced by 50 U/ml interferon-gamma from 62 (12)% of cells (mean SD) to 29 (20)% (p less than 0.005). Aminosalicylic Acid 9-13 interferon gamma Homo sapiens 55-71 1740279-12 1992 5ASA, N-acetyl 5ASA, 4ASA, N-acetyl 4ASA, olsalazine and colchicine reduce interferon-gamma induced HLA-DR expression. Aminosalicylic Acid 0-4 interferon gamma Homo sapiens 75-91 1740279-12 1992 5ASA, N-acetyl 5ASA, 4ASA, N-acetyl 4ASA, olsalazine and colchicine reduce interferon-gamma induced HLA-DR expression. n-acetyl 5asa 6-19 interferon gamma Homo sapiens 75-91 1740279-12 1992 5ASA, N-acetyl 5ASA, 4ASA, N-acetyl 4ASA, olsalazine and colchicine reduce interferon-gamma induced HLA-DR expression. Aminosalicylic Acid 21-25 interferon gamma Homo sapiens 75-91 1740279-12 1992 5ASA, N-acetyl 5ASA, 4ASA, N-acetyl 4ASA, olsalazine and colchicine reduce interferon-gamma induced HLA-DR expression. n-acetyl 4asa 27-40 interferon gamma Homo sapiens 75-91 1740279-12 1992 5ASA, N-acetyl 5ASA, 4ASA, N-acetyl 4ASA, olsalazine and colchicine reduce interferon-gamma induced HLA-DR expression. olsalazine 42-52 interferon gamma Homo sapiens 75-91 1740279-12 1992 5ASA, N-acetyl 5ASA, 4ASA, N-acetyl 4ASA, olsalazine and colchicine reduce interferon-gamma induced HLA-DR expression. Colchicine 57-67 interferon gamma Homo sapiens 75-91 1347751-2 1992 In the present study, we investigated the effect of nicotinamide, an inhibitor of poly(ADP ribose) synthetase, on interferon-gamma (IFN gamma)-induced ICAM-1 and HLA-DR antigen expression on the surface of cultured human umbilical vein endothelial cells, assessed by flow cytometry, and EC proliferation by counting cell numbers and [3H]thymidine incorporation assays. Niacinamide 52-64 interferon gamma Homo sapiens 114-130 1347751-2 1992 In the present study, we investigated the effect of nicotinamide, an inhibitor of poly(ADP ribose) synthetase, on interferon-gamma (IFN gamma)-induced ICAM-1 and HLA-DR antigen expression on the surface of cultured human umbilical vein endothelial cells, assessed by flow cytometry, and EC proliferation by counting cell numbers and [3H]thymidine incorporation assays. Tritium 334-336 interferon gamma Homo sapiens 114-130 1371491-8 1992 When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha. Tacrolimus 123-128 interferon gamma Homo sapiens 212-221 1371491-8 1992 When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha. Phorbol Esters 34-47 interferon gamma Homo sapiens 212-221 1371491-8 1992 When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha. Cyclosporine 133-136 interferon gamma Homo sapiens 212-221 1371491-8 1992 When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha. Tetradecanoylphorbol Acetate 49-80 interferon gamma Homo sapiens 212-221 1371491-8 1992 When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha. Tetradecanoylphorbol Acetate 82-85 interferon gamma Homo sapiens 212-221 1371491-10 1992 Further stimulation by addition of anti-CD28 mAb to the cultures resulted in an augmented IL-2 and IFN-gamma production which was resistant to both FK506 and CsA. Tacrolimus 148-153 interferon gamma Homo sapiens 99-108 1371491-8 1992 When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha. Calcium 92-99 interferon gamma Homo sapiens 212-221 1483067-0 1992 Interferon-gamma production in atopic dermatitis: a role for prostaglandins? Prostaglandins 61-75 interferon gamma Homo sapiens 0-16 1371491-8 1992 When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha. Ionomycin 111-120 interferon gamma Homo sapiens 212-221 1483067-4 1992 In addition, IFN-gamma production could be increased by either pre-culturing the cells for 3 days prior to PHA stimulation or by addition of indomethacin to the culture medium. Indomethacin 141-153 interferon gamma Homo sapiens 13-22 1483067-6 1992 The possibility that prostaglandins mediate the suppressed production of IFN-gamma in AD was supported by demonstrating that exogenous prostaglandin E2 (PGE2) inhibited IFN-gamma production in PHA-stimulated PBMC. Prostaglandins 21-35 interferon gamma Homo sapiens 73-82 1483067-6 1992 The possibility that prostaglandins mediate the suppressed production of IFN-gamma in AD was supported by demonstrating that exogenous prostaglandin E2 (PGE2) inhibited IFN-gamma production in PHA-stimulated PBMC. Prostaglandins 21-35 interferon gamma Homo sapiens 169-178 1483067-6 1992 The possibility that prostaglandins mediate the suppressed production of IFN-gamma in AD was supported by demonstrating that exogenous prostaglandin E2 (PGE2) inhibited IFN-gamma production in PHA-stimulated PBMC. Dinoprostone 135-151 interferon gamma Homo sapiens 73-82 1517529-8 1992 IFN-gamma is released in high quantities by lymphocytes treated with Propofol. Propofol 69-77 interferon gamma Homo sapiens 0-9 1483067-6 1992 The possibility that prostaglandins mediate the suppressed production of IFN-gamma in AD was supported by demonstrating that exogenous prostaglandin E2 (PGE2) inhibited IFN-gamma production in PHA-stimulated PBMC. Dinoprostone 135-151 interferon gamma Homo sapiens 169-178 1517529-9 1992 Dormicum, Ketalar and Penthotal induce non-significant increase of IFN-gamma release. Midazolam 0-8 interferon gamma Homo sapiens 67-76 1517529-9 1992 Dormicum, Ketalar and Penthotal induce non-significant increase of IFN-gamma release. Ketamine 10-17 interferon gamma Homo sapiens 67-76 1517529-9 1992 Dormicum, Ketalar and Penthotal induce non-significant increase of IFN-gamma release. penthotal 22-31 interferon gamma Homo sapiens 67-76 1483067-6 1992 The possibility that prostaglandins mediate the suppressed production of IFN-gamma in AD was supported by demonstrating that exogenous prostaglandin E2 (PGE2) inhibited IFN-gamma production in PHA-stimulated PBMC. Dinoprostone 153-157 interferon gamma Homo sapiens 73-82 1483067-6 1992 The possibility that prostaglandins mediate the suppressed production of IFN-gamma in AD was supported by demonstrating that exogenous prostaglandin E2 (PGE2) inhibited IFN-gamma production in PHA-stimulated PBMC. Dinoprostone 153-157 interferon gamma Homo sapiens 169-178 1483067-8 1992 Our data suggest that alterations in prostaglandin metabolism play a crucial role in the pathogenesis of AD by inhibiting the production of IFN-gamma. Prostaglandins 37-50 interferon gamma Homo sapiens 140-149 1345792-3 1992 We show that NKSF synergizes with IL-2 and phorbol diesters inducing the accumulation of IFN-gamma mRNA in PHA-activated T cell blasts. phorbol 43-50 interferon gamma Homo sapiens 89-98 1339119-2 1992 Interferon gamma treatment did stimulate superoxide generation and bone resorption in patients with osteopetrosis as evidenced by a reduction in bone volume and an increase in biochemical markers of bone resorption. Superoxides 41-51 interferon gamma Homo sapiens 0-16 1532618-7 1992 Our data suggest that indoleamine-2,3-dioxygenase (IDO), the rate limiting enzyme of the kynurenine pathway of L-tryptophan metabolism, was activated in both syndromes by cytokines including IFN-gamma, and that perhaps products of tryptophan metabolism played a role in the pathogenesis of EMS and TOS. Kynurenine 89-99 interferon gamma Homo sapiens 191-200 1532618-7 1992 Our data suggest that indoleamine-2,3-dioxygenase (IDO), the rate limiting enzyme of the kynurenine pathway of L-tryptophan metabolism, was activated in both syndromes by cytokines including IFN-gamma, and that perhaps products of tryptophan metabolism played a role in the pathogenesis of EMS and TOS. Tryptophan 111-123 interferon gamma Homo sapiens 191-200 1532618-7 1992 Our data suggest that indoleamine-2,3-dioxygenase (IDO), the rate limiting enzyme of the kynurenine pathway of L-tryptophan metabolism, was activated in both syndromes by cytokines including IFN-gamma, and that perhaps products of tryptophan metabolism played a role in the pathogenesis of EMS and TOS. Tryptophan 113-123 interferon gamma Homo sapiens 191-200 1542209-13 1992 PAM with TNF-alpha pretreatment, and PAM with IFN-gamma pretreatment could release increased amount of O2- significantly, compared with control. Oxygen 103-105 interferon gamma Homo sapiens 46-55 1764037-6 1991 IFN-gamma- or 5-HT-stimulated (but not resting) cells produced NAHT and melatonin. N-acetylserotonin 63-67 interferon gamma Homo sapiens 0-9 1560730-1 1992 Macrophages and other host cells activated by interferon-gamma (IFN-gamma) can be induced to form a flavoprotein that converts L-arginine to nitric oxide+L-citrulline. Arginine 127-137 interferon gamma Homo sapiens 46-62 1560730-1 1992 Macrophages and other host cells activated by interferon-gamma (IFN-gamma) can be induced to form a flavoprotein that converts L-arginine to nitric oxide+L-citrulline. Arginine 127-137 interferon gamma Homo sapiens 64-73 1560730-1 1992 Macrophages and other host cells activated by interferon-gamma (IFN-gamma) can be induced to form a flavoprotein that converts L-arginine to nitric oxide+L-citrulline. Nitric Oxide 141-153 interferon gamma Homo sapiens 46-62 1560730-1 1992 Macrophages and other host cells activated by interferon-gamma (IFN-gamma) can be induced to form a flavoprotein that converts L-arginine to nitric oxide+L-citrulline. Nitric Oxide 141-153 interferon gamma Homo sapiens 64-73 1560730-1 1992 Macrophages and other host cells activated by interferon-gamma (IFN-gamma) can be induced to form a flavoprotein that converts L-arginine to nitric oxide+L-citrulline. Citrulline 154-166 interferon gamma Homo sapiens 46-62 1560730-1 1992 Macrophages and other host cells activated by interferon-gamma (IFN-gamma) can be induced to form a flavoprotein that converts L-arginine to nitric oxide+L-citrulline. Citrulline 154-166 interferon gamma Homo sapiens 64-73 1560730-3 1992 In the absence of L-arginine, IFN-gamma-induced infected cells can lower their net uptake of iron. Iron 93-97 interferon gamma Homo sapiens 30-39 1662603-3 1991 The IFN-gamma analogue proteins were shortened by 10 (C-10L), 11 (C-11, C-11L), 14 (C-14L), 19 (C-19L) and 20 (C-20) amino acid. Carbon 54-55 interferon gamma Homo sapiens 4-13 1662603-3 1991 The IFN-gamma analogue proteins were shortened by 10 (C-10L), 11 (C-11, C-11L), 14 (C-14L), 19 (C-19L) and 20 (C-20) amino acid. Carbon 66-67 interferon gamma Homo sapiens 4-13 1662603-3 1991 The IFN-gamma analogue proteins were shortened by 10 (C-10L), 11 (C-11, C-11L), 14 (C-14L), 19 (C-19L) and 20 (C-20) amino acid. Carbon 66-67 interferon gamma Homo sapiens 4-13 1662603-3 1991 The IFN-gamma analogue proteins were shortened by 10 (C-10L), 11 (C-11, C-11L), 14 (C-14L), 19 (C-19L) and 20 (C-20) amino acid. Carbon 66-67 interferon gamma Homo sapiens 4-13 1662603-3 1991 The IFN-gamma analogue proteins were shortened by 10 (C-10L), 11 (C-11, C-11L), 14 (C-14L), 19 (C-19L) and 20 (C-20) amino acid. Carbon 66-67 interferon gamma Homo sapiens 4-13 1662603-5 1991 The expression rates of precipitating IFN-gamma variants in E. coli cells (wild type, C-10L, C-11, C-11L) amount to 35-40% of the total protein, in contrast to 14-21% for the mainly soluble ones (C-14L, C-20). Carbon 86-87 interferon gamma Homo sapiens 38-47 1662603-5 1991 The expression rates of precipitating IFN-gamma variants in E. coli cells (wild type, C-10L, C-11, C-11L) amount to 35-40% of the total protein, in contrast to 14-21% for the mainly soluble ones (C-14L, C-20). Carbon 93-94 interferon gamma Homo sapiens 38-47 1662603-5 1991 The expression rates of precipitating IFN-gamma variants in E. coli cells (wild type, C-10L, C-11, C-11L) amount to 35-40% of the total protein, in contrast to 14-21% for the mainly soluble ones (C-14L, C-20). Carbon 93-94 interferon gamma Homo sapiens 38-47 1764037-6 1991 IFN-gamma- or 5-HT-stimulated (but not resting) cells produced NAHT and melatonin. Melatonin 72-81 interferon gamma Homo sapiens 0-9 1763065-15 1991 The gamma 2 protein is shown to possess tryptophan-dependent aminoacyl-tRNA synthetase activity and thus constitutes an enzymatic activity involved in the biological activity of IFN-gamma. Tryptophan 40-50 interferon gamma Homo sapiens 178-187 1764697-7 1991 We conclude that TNF potentiates the cytotoxic effects of TAM in MCF-7 cells and that the three cytokines IFN-alpha, IFN-gamma, and TNF share some pathways that lead to specific induction of some cytokine responsive genes. Tamoxifen 58-61 interferon gamma Homo sapiens 117-126 1934072-3 1991 The expression of HLA-DR molecules induced by IFN-gamma was blocked by the protein kinase C (PKC) inhibitors sphingosine, staurosporine, and H7. Sphingosine 109-120 interferon gamma Homo sapiens 46-55 1667256-3 1991 We now report that stimulation of macrophages either with recombinant human gamma interferon (IFN-gamma, 10(2) U/ml) or with recombinant human TNF-alpha (10(2) U/ml) resulted in an increase in the intracellular concentration of azithromycin by approximately 200% within 3 h, compared with the concentration in unstimulated macrophages. Azithromycin 228-240 interferon gamma Homo sapiens 76-103 1721013-9 1991 Io in combination with phorbol-ester induced the secretion of larger amounts of IL-4, GM-CSF, TNF-alpha and low amounts of IFN-gamma. Ionomycin 0-2 interferon gamma Homo sapiens 123-132 1721013-9 1991 Io in combination with phorbol-ester induced the secretion of larger amounts of IL-4, GM-CSF, TNF-alpha and low amounts of IFN-gamma. Phorbol Esters 23-36 interferon gamma Homo sapiens 123-132 1934072-3 1991 The expression of HLA-DR molecules induced by IFN-gamma was blocked by the protein kinase C (PKC) inhibitors sphingosine, staurosporine, and H7. Staurosporine 122-135 interferon gamma Homo sapiens 46-55 1934072-3 1991 The expression of HLA-DR molecules induced by IFN-gamma was blocked by the protein kinase C (PKC) inhibitors sphingosine, staurosporine, and H7. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 141-143 interferon gamma Homo sapiens 46-55 1934072-8 1991 However, pretreatment with PMA for 24 hr prior to IFN-gamma stimulation decreased the IFN-gamma-induced expression of HLA-DR without decreasing IFN-gamma receptor levels. Tetradecanoylphorbol Acetate 27-30 interferon gamma Homo sapiens 86-95 1934072-8 1991 However, pretreatment with PMA for 24 hr prior to IFN-gamma stimulation decreased the IFN-gamma-induced expression of HLA-DR without decreasing IFN-gamma receptor levels. Tetradecanoylphorbol Acetate 27-30 interferon gamma Homo sapiens 86-95 1839957-8 1991 Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser. Arginine 130-133 interferon gamma Homo sapiens 28-37 1719091-5 1991 After pretreatment of U937 cells with IFN-gamma to augment the sensitivity to TNF, an inhibitory effect of rADF was also found. radf 107-111 interferon gamma Homo sapiens 38-47 1839957-8 1991 Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser. Glycine 134-137 interferon gamma Homo sapiens 28-37 1839957-8 1991 Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser. Aspartic Acid 138-141 interferon gamma Homo sapiens 28-37 1839957-8 1991 Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser. Serine 142-145 interferon gamma Homo sapiens 28-37 1839957-8 1991 Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser. Glycine 189-192 interferon gamma Homo sapiens 28-37 1839957-8 1991 Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser. Glutamic Acid 193-196 interferon gamma Homo sapiens 28-37 1839957-8 1991 Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser. Serine 197-200 interferon gamma Homo sapiens 28-37 1937963-3 1991 Treatment of ACHN cells with rh IFN-gamma also leads to inhibition of proliferation of these cells in a dose-dependent manner, that can be reversed by exogenous rh IL-6, while IFN-alpha, IL-2, IL-4 and vinblastine or 17-beta-estradiol has no effect on growth (3H-thymidine uptake) of ACHN cells and IL-6 expression. Vinblastine 202-213 interferon gamma Homo sapiens 32-41 1955563-4 1991 Interleukin-1 beta, prostaglandin E2 and transforming growth factor-beta suppressed IFN gamma-induced HLADR expression in HTB16 cells. Dinoprostone 20-36 interferon gamma Homo sapiens 84-93 1824254-2 1991 When added with myeloid growth factors (interleukin-3 [IL-3], granulocyte-macrophage colony-stimulating factor [GM-CSF], or macrophage-CSF [M-CSF]), IFN-gamma inhibited the formation of colonies in soft agar assays. Agar 203-207 interferon gamma Homo sapiens 149-158 1824254-4 1991 IFN-gamma also inhibited M-CSF-, GM-CSF-, or IL-3-stimulated [3H]-thymidine incorporation in highly enriched GM-CFC. Tritium 62-64 interferon gamma Homo sapiens 0-9 1824254-4 1991 IFN-gamma also inhibited M-CSF-, GM-CSF-, or IL-3-stimulated [3H]-thymidine incorporation in highly enriched GM-CFC. Thymidine 66-75 interferon gamma Homo sapiens 0-9 1824254-4 1991 IFN-gamma also inhibited M-CSF-, GM-CSF-, or IL-3-stimulated [3H]-thymidine incorporation in highly enriched GM-CFC. gm- 33-36 interferon gamma Homo sapiens 0-9 1824254-7 1991 However, the effect of IFN-gamma on intracellular pH and DNA synthesis was transient and pretreatment with IFN markedly inhibited the ability of GM-CSF, M-CSF, and IL-3 to activate the sodium/hydrogen antiport. Sodium 185-191 interferon gamma Homo sapiens 23-32 1824254-7 1991 However, the effect of IFN-gamma on intracellular pH and DNA synthesis was transient and pretreatment with IFN markedly inhibited the ability of GM-CSF, M-CSF, and IL-3 to activate the sodium/hydrogen antiport. Hydrogen 192-200 interferon gamma Homo sapiens 23-32 1937963-3 1991 Treatment of ACHN cells with rh IFN-gamma also leads to inhibition of proliferation of these cells in a dose-dependent manner, that can be reversed by exogenous rh IL-6, while IFN-alpha, IL-2, IL-4 and vinblastine or 17-beta-estradiol has no effect on growth (3H-thymidine uptake) of ACHN cells and IL-6 expression. 3h-thymidine 260-272 interferon gamma Homo sapiens 32-41 1937963-3 1991 Treatment of ACHN cells with rh IFN-gamma also leads to inhibition of proliferation of these cells in a dose-dependent manner, that can be reversed by exogenous rh IL-6, while IFN-alpha, IL-2, IL-4 and vinblastine or 17-beta-estradiol has no effect on growth (3H-thymidine uptake) of ACHN cells and IL-6 expression. Estradiol 217-234 interferon gamma Homo sapiens 32-41 1937963-3 1991 Treatment of ACHN cells with rh IFN-gamma also leads to inhibition of proliferation of these cells in a dose-dependent manner, that can be reversed by exogenous rh IL-6, while IFN-alpha, IL-2, IL-4 and vinblastine or 17-beta-estradiol has no effect on growth (3H-thymidine uptake) of ACHN cells and IL-6 expression. 1,1'-Azobis(cyanocyclohexane) 13-17 interferon gamma Homo sapiens 32-41 1952427-10 1991 Dexamethasone (10(-7) mol/L) significantly inhibited the production of interleukin-2 and interferon-gamma by proliferating T lymphocytes isolated from the glucocorticoid-sensitive but not the resistant chronic asthmatic patients. Dexamethasone 0-13 interferon gamma Homo sapiens 89-105 1934607-6 1991 In vitro studies have shown that neutrophils and monocytes derived from patients with autosomal recessive cytochrome b-positive CGD respond to interferon-gamma with an enhanced respiratory burst (superoxide production) and increased bactericidal activity. Superoxides 196-206 interferon gamma Homo sapiens 143-159 1752366-0 1991 Relationship between interferon-gamma, indoleamine-2,3-dioxygenase and tryptophan. Tryptophan 71-81 interferon gamma Homo sapiens 21-37 1934596-7 1991 Four LL patients with positive T cell response to BCG responded with detectable lymphoproliferative response and IFN-gamma secretion to antigen 85. bcg 50-53 interferon gamma Homo sapiens 113-122 1811217-5 1991 Thus, the fever of vivax malaria was associated with IFN-gamma induced macrophage activation, as reflected by neopterin excretion. Neopterin 110-119 interferon gamma Homo sapiens 53-62 1918978-0 1991 IFN-gamma enhances sensitivity of human macrophages to extracellular ATP-mediated lysis. Adenosine Triphosphate 69-72 interferon gamma Homo sapiens 0-9 1832999-5 1991 Receptor-bound 125I Hu-recombinant IFN-gamma was rapidly internalized and degraded when the temperature was increased from 4 degrees C to 37 degrees C. The half-life of this receptor was about 7 hours, and pretreatment of cells with IFN-gamma or phorbol myristate acetate had very little effect on the surface receptor number and no detectable effect on IFN-gamma receptor messenger RNA (mRNA) expression. Tetradecanoylphorbol Acetate 246-271 interferon gamma Homo sapiens 35-44 1832999-5 1991 Receptor-bound 125I Hu-recombinant IFN-gamma was rapidly internalized and degraded when the temperature was increased from 4 degrees C to 37 degrees C. The half-life of this receptor was about 7 hours, and pretreatment of cells with IFN-gamma or phorbol myristate acetate had very little effect on the surface receptor number and no detectable effect on IFN-gamma receptor messenger RNA (mRNA) expression. Tetradecanoylphorbol Acetate 246-271 interferon gamma Homo sapiens 233-242 1832999-5 1991 Receptor-bound 125I Hu-recombinant IFN-gamma was rapidly internalized and degraded when the temperature was increased from 4 degrees C to 37 degrees C. The half-life of this receptor was about 7 hours, and pretreatment of cells with IFN-gamma or phorbol myristate acetate had very little effect on the surface receptor number and no detectable effect on IFN-gamma receptor messenger RNA (mRNA) expression. Tetradecanoylphorbol Acetate 246-271 interferon gamma Homo sapiens 233-242 1681733-6 1991 In keeping with these biological activities and protein data, Northern blot analysis of total cellular RNA extracted from keratinocyte monolayers hybridized with a 32P-labelled 1-kb cDNA to IL-8 mRNA, revealed induction of the IL-8 gene in the presence of TNF-alpha and IL-1 beta, but not IFN-gamma. Phosphorus-32 164-167 interferon gamma Homo sapiens 289-298 1918978-4 1991 In addition, IFN-gamma-treated macrophages released approximately 80% of 51Cr label within 15 min after the addition of ATPo, whereas GM-CSF-treated cells did not release significant levels of radiolabel until 4 to 6 h after initial stimulation with ATPo. Chromium-51 73-77 interferon gamma Homo sapiens 13-22 1918978-6 1991 Thus, IFN-gamma treatment of macrophages elicited increased sensitivity to ATPo-mediated lysis, a phenomenon characterized by rapid release of 51Cr from labeled cells and which is possibly due to induction or activation of surface ATP-binding receptors different from those present on GM-CSF-treated or untreated macrophages. Chromium-51 143-147 interferon gamma Homo sapiens 6-15 1718390-10 1991 However, the addition of the following cytokines to retinoids potentiated the retinoid-induced differentiation: IFN alpha, IFN beta, IFN gamma, TNF alpha, G-CSF, IL-1 alpha and IL-4. Retinoids 52-61 interferon gamma Homo sapiens 133-142 1909215-3 1991 In PMNC cultures, He-PC dose-dependently enhanced the production of IFN-g, provided IL-2 had been added exogenously. Helium 18-20 interferon gamma Homo sapiens 68-73 1668255-1 1991 Reaction of homopyrimidine oligonucleotides bearing a 5"-terminal alkylating aromatic 2-chloroethyl-amino group with a bovine papilloma vector expressing human interferon-gamma was investigated. homopyrimidine oligonucleotides 12-43 interferon gamma Homo sapiens 160-176 1909215-5 1991 In some cultures, at a concentration of 8 micrograms/ml He-PC stimulated the secretion of IFN-g more than 20-fold compared to untreated controls. Helium 56-58 interferon gamma Homo sapiens 90-95 1909216-0 1991 The defective in vitro expression of interferon-gamma messenger RNA in rheumatoid arthritis is recovered by cycloheximide. Cycloheximide 108-121 interferon gamma Homo sapiens 37-53 1909216-2 1991 In this study, we have examined the superinduction effect of cycloheximide (CHX) on the IFN-gamma mRNA expression in PHA-stimulated T lymphocytes from nine patients with active RA compared to three healthy individuals. Cycloheximide 61-74 interferon gamma Homo sapiens 88-97 1909216-2 1991 In this study, we have examined the superinduction effect of cycloheximide (CHX) on the IFN-gamma mRNA expression in PHA-stimulated T lymphocytes from nine patients with active RA compared to three healthy individuals. Cycloheximide 76-79 interferon gamma Homo sapiens 88-97 1833098-7 1991 These results suggest that TNF-alpha and IFN-gamma influence the activation, phenotypic, and functional outcome of MLTC-generated CTL, and may account for the phenotypic variations observed in T cell populations generated in vitro. mltc 115-119 interferon gamma Homo sapiens 41-50 1917395-4 1991 Catabolism of up to 38% of available tryptophan occurred in IFN-gamma-treated cells in contrast to controls that showed only baseline activity. Tryptophan 37-47 interferon gamma Homo sapiens 60-69 1917395-6 1991 Reversal by the addition of exogenous tryptophan substantiated that IFN-gamma-mediated induction of IDO and catabolism of tryptophan were responsible for inhibition of intracellular growth of C. trachomatis. Tryptophan 38-48 interferon gamma Homo sapiens 68-77 1917395-6 1991 Reversal by the addition of exogenous tryptophan substantiated that IFN-gamma-mediated induction of IDO and catabolism of tryptophan were responsible for inhibition of intracellular growth of C. trachomatis. Tryptophan 122-132 interferon gamma Homo sapiens 68-77 1918366-3 1991 In previous studies, we have demonstrated that L. pneumophila intracellular multiplication in human monocytes is iron dependent and that IFN gamma-activated monocytes inhibit L. pneumophila intracellular multiplication by limiting the availability of iron. Iron 251-255 interferon gamma Homo sapiens 137-146 1918366-9 1991 Similarly, the nonphysiologic iron chelates ferric nitrilotriacetate and ferric ammonium citrate completely reverse and ferric pyrophosphate partially reversed the capacity of IFN gamma-activated monocytes to inhibit L. pneumophila intracellular multiplication, demonstrating that L. pneumophila can utilize iron derived from nonphysiologic iron chelates internalized by monocytes independently of the transferrin and lactoferrin endocytic pathways. Iron 30-34 interferon gamma Homo sapiens 176-185 1919633-2 1991 The addition of TNF alpha to IFN gamma reduced both the magnitude and duration of IFN gamma-mediated effects on peripheral blood monocyte expression of Fc receptors (FcRs) and HLA-DR and production of hydrogen peroxide. Hydrogen Peroxide 201-218 interferon gamma Homo sapiens 29-38 1919633-2 1991 The addition of TNF alpha to IFN gamma reduced both the magnitude and duration of IFN gamma-mediated effects on peripheral blood monocyte expression of Fc receptors (FcRs) and HLA-DR and production of hydrogen peroxide. Hydrogen Peroxide 201-218 interferon gamma Homo sapiens 82-91 1918366-9 1991 Similarly, the nonphysiologic iron chelates ferric nitrilotriacetate and ferric ammonium citrate completely reverse and ferric pyrophosphate partially reversed the capacity of IFN gamma-activated monocytes to inhibit L. pneumophila intracellular multiplication, demonstrating that L. pneumophila can utilize iron derived from nonphysiologic iron chelates internalized by monocytes independently of the transferrin and lactoferrin endocytic pathways. ferric pyrophosphate 120-140 interferon gamma Homo sapiens 176-185 1919633-4 1991 On the other hand, TNF alpha and IFN gamma appeared to have an additive stimulatory effect on the production of neopterin by monocytes. Neopterin 112-121 interferon gamma Homo sapiens 33-42 1919633-5 1991 The highest serum levels of neopterin were detected in patients who received the highest doses of both IFN gamma and TNF alpha. Neopterin 28-37 interferon gamma Homo sapiens 103-112 1918366-9 1991 Similarly, the nonphysiologic iron chelates ferric nitrilotriacetate and ferric ammonium citrate completely reverse and ferric pyrophosphate partially reversed the capacity of IFN gamma-activated monocytes to inhibit L. pneumophila intracellular multiplication, demonstrating that L. pneumophila can utilize iron derived from nonphysiologic iron chelates internalized by monocytes independently of the transferrin and lactoferrin endocytic pathways. Iron 308-312 interferon gamma Homo sapiens 176-185 1918366-9 1991 Similarly, the nonphysiologic iron chelates ferric nitrilotriacetate and ferric ammonium citrate completely reverse and ferric pyrophosphate partially reversed the capacity of IFN gamma-activated monocytes to inhibit L. pneumophila intracellular multiplication, demonstrating that L. pneumophila can utilize iron derived from nonphysiologic iron chelates internalized by monocytes independently of the transferrin and lactoferrin endocytic pathways. Iron 308-312 interferon gamma Homo sapiens 176-185 1907805-7 1991 Herein the authors demonstrate that alterations in the cytoskeleton induced by DHCB and CD can lead to increases in IFN-gamma-induced MHC gene expression. dihydrocytochalasin B 79-83 interferon gamma Homo sapiens 116-125 1917946-4 1991 We found that amiloride and ethyl isopropylamiloride, inhibitors of Na+/H+ exchange, blocked IFN-gamma-induced class II gene expression. Amiloride 14-23 interferon gamma Homo sapiens 93-102 1917946-4 1991 We found that amiloride and ethyl isopropylamiloride, inhibitors of Na+/H+ exchange, blocked IFN-gamma-induced class II gene expression. ethylisopropylamiloride 28-52 interferon gamma Homo sapiens 93-102 1917946-5 1991 IFN-gamma stimulated Na+ influx, and this increased influx was inhibited by amiloride. Amiloride 76-85 interferon gamma Homo sapiens 0-9 1917946-8 1991 H7 and another PKC inhibitor, staurosporine, inhibited IFN-gamma-induced class II gene expression. Staurosporine 30-43 interferon gamma Homo sapiens 55-64 1959942-2 1991 In the present study we describe a one-step chromatographic procedure for the purification of the anti-IFN-gamma antibodies from human Ig preparations, using a recombinant IFN-gamma-coupled Sepharose CL4B affinity column. Sepharose 190-199 interferon gamma Homo sapiens 103-112 1959942-2 1991 In the present study we describe a one-step chromatographic procedure for the purification of the anti-IFN-gamma antibodies from human Ig preparations, using a recombinant IFN-gamma-coupled Sepharose CL4B affinity column. Sepharose 190-199 interferon gamma Homo sapiens 172-181 1880416-2 1991 It was specifically down-modulated after stimulation of monocytes by physiologic activating/differentiating agents such as bacterial LPS and IFN-gamma, by the pharmacologic agents PMA and calcium ionophore A23187, and by anti-CD14 antibodies. Calcium 188-195 interferon gamma Homo sapiens 141-150 1907805-6 1991 The authors have studied the effect of DHCB and CD on IFN-gamma-induced MHC gene expression in 143 B cells, a human osteosarcoma-derived cell line. dihydrocytochalasin B 39-43 interferon gamma Homo sapiens 54-63 1907805-6 1991 The authors have studied the effect of DHCB and CD on IFN-gamma-induced MHC gene expression in 143 B cells, a human osteosarcoma-derived cell line. Cytochalasin D 48-50 interferon gamma Homo sapiens 54-63 1907805-7 1991 Herein the authors demonstrate that alterations in the cytoskeleton induced by DHCB and CD can lead to increases in IFN-gamma-induced MHC gene expression. Cytochalasin D 88-90 interferon gamma Homo sapiens 116-125 1907805-8 1991 Dihydrocytochalasin B added up to 3 hours after IFN-gamma results in a threefold to sixfold increase in levels of class II mRNA while producing minimal enhancement of class I gene expression. dihydrocytochalasin B 0-21 interferon gamma Homo sapiens 48-57 1907805-11 1991 Studies using 125I-IFN-gamma demonstrate that the occupied IFN-gamma receptor associates with a Triton X-100 insoluble fraction of 143 B cells and that DHCB and CD markedly inhibit this association. Octoxynol 96-108 interferon gamma Homo sapiens 19-28 1907805-11 1991 Studies using 125I-IFN-gamma demonstrate that the occupied IFN-gamma receptor associates with a Triton X-100 insoluble fraction of 143 B cells and that DHCB and CD markedly inhibit this association. Octoxynol 96-108 interferon gamma Homo sapiens 59-68 1907805-11 1991 Studies using 125I-IFN-gamma demonstrate that the occupied IFN-gamma receptor associates with a Triton X-100 insoluble fraction of 143 B cells and that DHCB and CD markedly inhibit this association. dihydrocytochalasin B 152-156 interferon gamma Homo sapiens 19-28 1907805-11 1991 Studies using 125I-IFN-gamma demonstrate that the occupied IFN-gamma receptor associates with a Triton X-100 insoluble fraction of 143 B cells and that DHCB and CD markedly inhibit this association. dihydrocytochalasin B 152-156 interferon gamma Homo sapiens 59-68 1907805-11 1991 Studies using 125I-IFN-gamma demonstrate that the occupied IFN-gamma receptor associates with a Triton X-100 insoluble fraction of 143 B cells and that DHCB and CD markedly inhibit this association. Cytochalasin D 161-163 interferon gamma Homo sapiens 19-28 1907805-11 1991 Studies using 125I-IFN-gamma demonstrate that the occupied IFN-gamma receptor associates with a Triton X-100 insoluble fraction of 143 B cells and that DHCB and CD markedly inhibit this association. Cytochalasin D 161-163 interferon gamma Homo sapiens 59-68 1907934-0 1991 Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. Tryptophan 72-82 interferon gamma Homo sapiens 21-66 1907934-3 1991 In particular, interferon-gamma (IFN-gamma) induces an enzyme of tryptophan catabolism, indoleamine 2,3-dioxygenase (IDO), which is responsible for conversion of tryptophan and other indole derivatives to kynurenine. Tryptophan 65-75 interferon gamma Homo sapiens 15-31 1907934-3 1991 In particular, interferon-gamma (IFN-gamma) induces an enzyme of tryptophan catabolism, indoleamine 2,3-dioxygenase (IDO), which is responsible for conversion of tryptophan and other indole derivatives to kynurenine. Tryptophan 65-75 interferon gamma Homo sapiens 33-42 1907934-3 1991 In particular, interferon-gamma (IFN-gamma) induces an enzyme of tryptophan catabolism, indoleamine 2,3-dioxygenase (IDO), which is responsible for conversion of tryptophan and other indole derivatives to kynurenine. Tryptophan 162-172 interferon gamma Homo sapiens 15-31 1907934-3 1991 In particular, interferon-gamma (IFN-gamma) induces an enzyme of tryptophan catabolism, indoleamine 2,3-dioxygenase (IDO), which is responsible for conversion of tryptophan and other indole derivatives to kynurenine. Tryptophan 162-172 interferon gamma Homo sapiens 33-42 1907934-3 1991 In particular, interferon-gamma (IFN-gamma) induces an enzyme of tryptophan catabolism, indoleamine 2,3-dioxygenase (IDO), which is responsible for conversion of tryptophan and other indole derivatives to kynurenine. indole 88-94 interferon gamma Homo sapiens 15-31 1907934-3 1991 In particular, interferon-gamma (IFN-gamma) induces an enzyme of tryptophan catabolism, indoleamine 2,3-dioxygenase (IDO), which is responsible for conversion of tryptophan and other indole derivatives to kynurenine. indole 88-94 interferon gamma Homo sapiens 33-42 1907934-3 1991 In particular, interferon-gamma (IFN-gamma) induces an enzyme of tryptophan catabolism, indoleamine 2,3-dioxygenase (IDO), which is responsible for conversion of tryptophan and other indole derivatives to kynurenine. Kynurenine 205-215 interferon gamma Homo sapiens 15-31 1907934-3 1991 In particular, interferon-gamma (IFN-gamma) induces an enzyme of tryptophan catabolism, indoleamine 2,3-dioxygenase (IDO), which is responsible for conversion of tryptophan and other indole derivatives to kynurenine. Kynurenine 205-215 interferon gamma Homo sapiens 33-42 1713200-1 1991 Incubation of large granular lymphocytes (LGL) with glutaraldehyde-fixed bacteria stimulated in the supernatant the production of interferon (IFN), which proved to be mainly IFN-gamma. Glutaral 52-66 interferon gamma Homo sapiens 174-183 1655916-5 1991 In the early post Tx period, the administration of antithymocyte globulin (ATG) or OKT3 monoclonal antibody and peak dosages of azathioprine were associated with significantly inhibited in vitro IFN-gamma production. Azathioprine 128-140 interferon gamma Homo sapiens 195-204 1907306-4 1991 We found that most clones from both the peripheral blood and CSF express IL-1, IL-2, IL-4, IFN-gamma, or TNF-alpha cytokine mRNA after activation with ionomycin and PMA. Ionomycin 151-160 interferon gamma Homo sapiens 91-100 1942774-3 1991 The latter was achieved by analyzing the superinduction of IL-2 and IFN-gamma mRNA occurring upon culture with cycloheximide or after low-dose gamma-irradiation, respectively. Cycloheximide 111-124 interferon gamma Homo sapiens 68-77 1831129-3 1991 In the presence of phytohemagglutinin or anti-T cell receptor monoclonal antibodies and phorbol 12-myristate 13-acetate, the IFN-gamma promoter is activated in human T cells, which can be further enhanced by co-transfection of the tax I or II genes. Tetradecanoylphorbol Acetate 88-119 interferon gamma Homo sapiens 125-134 1907763-5 1991 Protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA) could partially mimic IFN-gamma effect in inducing class II expression on endothelial cells. Tetradecanoylphorbol Acetate 33-64 interferon gamma Homo sapiens 93-102 1907763-5 1991 Protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA) could partially mimic IFN-gamma effect in inducing class II expression on endothelial cells. Tetradecanoylphorbol Acetate 66-69 interferon gamma Homo sapiens 93-102 1907763-6 1991 PMA together with another PKC activator arachidonic acid (AA) induced class II expression on endothelial cells as well as IFN-gamma. Tetradecanoylphorbol Acetate 0-3 interferon gamma Homo sapiens 122-131 1907763-6 1991 PMA together with another PKC activator arachidonic acid (AA) induced class II expression on endothelial cells as well as IFN-gamma. Arachidonic Acid 40-56 interferon gamma Homo sapiens 122-131 1712813-2 1991 Production of O2- in response to FMLP, TNF, IFN-gamma, platelet activating factor, LPS, substance P, and PMA by human eosinophils in suspension and in contact with polystyrene ELISA plastic (PL) or biologic surfaces was studied. Oxygen 14-16 interferon gamma Homo sapiens 44-53 1646088-0 1991 Interferon-gamma and immunoglobulin enhance mineral dust-induced production of reactive oxygen metabolites by human macrophages. Oxygen 88-94 interferon gamma Homo sapiens 0-16 1830034-4 1991 When 50 U/ml IFN-gamma were combined with 5-FU or FUdR, the antiproliferative effects were synergistic in those cell lines with sensitivity to IFN-gamma as a single agent, but not in the IFN-gamma-insensitive cell lines. Fluorouracil 42-46 interferon gamma Homo sapiens 143-152 1830034-4 1991 When 50 U/ml IFN-gamma were combined with 5-FU or FUdR, the antiproliferative effects were synergistic in those cell lines with sensitivity to IFN-gamma as a single agent, but not in the IFN-gamma-insensitive cell lines. Fluorouracil 42-46 interferon gamma Homo sapiens 143-152 1830034-4 1991 When 50 U/ml IFN-gamma were combined with 5-FU or FUdR, the antiproliferative effects were synergistic in those cell lines with sensitivity to IFN-gamma as a single agent, but not in the IFN-gamma-insensitive cell lines. 5-fluoro-2'-deoxyuridine 50-54 interferon gamma Homo sapiens 143-152 1830034-4 1991 When 50 U/ml IFN-gamma were combined with 5-FU or FUdR, the antiproliferative effects were synergistic in those cell lines with sensitivity to IFN-gamma as a single agent, but not in the IFN-gamma-insensitive cell lines. 5-fluoro-2'-deoxyuridine 50-54 interferon gamma Homo sapiens 143-152 1649023-11 1991 Further support for this hypothesis was obtained after interferon-gamma treatment of human monocytes which led to an augmented PMA-inducible release of active oxygen radicals, but was not paralleled by growth restriction of L. monocytogenes. Tetradecanoylphorbol Acetate 127-130 interferon gamma Homo sapiens 55-71 1649023-11 1991 Further support for this hypothesis was obtained after interferon-gamma treatment of human monocytes which led to an augmented PMA-inducible release of active oxygen radicals, but was not paralleled by growth restriction of L. monocytogenes. Reactive Oxygen Species 159-174 interferon gamma Homo sapiens 55-71 1717376-1 1991 Cyclosporin (CsA) and FK-506 are structurally distinct fungal metabolites, which exert powerful inhibitory effects on CD4+ T (helper) cell activation and on the secretion of interleukin-2 (IL-2) and other cytokines, including various cell growth factors and interferon-gamma. Cyclosporine 0-11 interferon gamma Homo sapiens 258-274 1717376-1 1991 Cyclosporin (CsA) and FK-506 are structurally distinct fungal metabolites, which exert powerful inhibitory effects on CD4+ T (helper) cell activation and on the secretion of interleukin-2 (IL-2) and other cytokines, including various cell growth factors and interferon-gamma. Tacrolimus 22-28 interferon gamma Homo sapiens 258-274 1763658-5 1991 In serum-free, estradiol-free, phenol-red-free chemically defined medium (Cancer Res 1984; 44: 4553), IFN gamma abolished in ZR75-1 but not in T47D the 30% growth stimulation induced by estradiol. Estradiol 15-24 interferon gamma Homo sapiens 102-111 1763658-5 1991 In serum-free, estradiol-free, phenol-red-free chemically defined medium (Cancer Res 1984; 44: 4553), IFN gamma abolished in ZR75-1 but not in T47D the 30% growth stimulation induced by estradiol. Phenolsulfonphthalein 31-41 interferon gamma Homo sapiens 102-111 1763658-5 1991 In serum-free, estradiol-free, phenol-red-free chemically defined medium (Cancer Res 1984; 44: 4553), IFN gamma abolished in ZR75-1 but not in T47D the 30% growth stimulation induced by estradiol. Estradiol 186-195 interferon gamma Homo sapiens 102-111 1904900-11 1991 The induction of Mn-SOD by IFN-gamma and its synergistic induction by IFN-gamma in combination with TNF and IL-1 should protect healthy cells from the toxicity of O2- during an immune response, and may provide a mechanism for selective killing of infected cells. Oxygen 163-165 interferon gamma Homo sapiens 27-36 1904900-11 1991 The induction of Mn-SOD by IFN-gamma and its synergistic induction by IFN-gamma in combination with TNF and IL-1 should protect healthy cells from the toxicity of O2- during an immune response, and may provide a mechanism for selective killing of infected cells. Oxygen 163-165 interferon gamma Homo sapiens 70-79 1648223-5 1991 However, the v-myc-associated block of phorbol 12-myristate 13-acetate-, 1 alpha,25-dihydroxycholecalciferol-, and retinoic acid-induced differentiation retinoic acid-induced differentiation can be overcome by adding interferon gamma as a costimulatory factor. Tetradecanoylphorbol Acetate 39-70 interferon gamma Homo sapiens 217-233 1675987-6 1991 Interferon-gamma also stimulated 1,25-(OH)2D production at low concentrations, but this was not additive to that by TNF. 1,25-(oh)2d 33-44 interferon gamma Homo sapiens 0-16 1648223-5 1991 However, the v-myc-associated block of phorbol 12-myristate 13-acetate-, 1 alpha,25-dihydroxycholecalciferol-, and retinoic acid-induced differentiation retinoic acid-induced differentiation can be overcome by adding interferon gamma as a costimulatory factor. Calcitriol 73-108 interferon gamma Homo sapiens 217-233 1648223-5 1991 However, the v-myc-associated block of phorbol 12-myristate 13-acetate-, 1 alpha,25-dihydroxycholecalciferol-, and retinoic acid-induced differentiation retinoic acid-induced differentiation can be overcome by adding interferon gamma as a costimulatory factor. Tretinoin 115-128 interferon gamma Homo sapiens 217-233 1648223-5 1991 However, the v-myc-associated block of phorbol 12-myristate 13-acetate-, 1 alpha,25-dihydroxycholecalciferol-, and retinoic acid-induced differentiation retinoic acid-induced differentiation can be overcome by adding interferon gamma as a costimulatory factor. Tretinoin 153-166 interferon gamma Homo sapiens 217-233 1645327-2 1991 Human monocytes cultured in the presence of human recombinant IFN-gamma exhibited an enhanced capacity to produce superoxide anion. Superoxides 114-130 interferon gamma Homo sapiens 62-71 1934174-1 1991 The interaction of recombinant human interferon-gamma (IFN) with egg phosphatidylcholine liposomes was studied. Phosphatidylcholines 69-88 interferon gamma Homo sapiens 37-53 1934174-1 1991 The interaction of recombinant human interferon-gamma (IFN) with egg phosphatidylcholine liposomes was studied. Phosphatidylcholines 69-88 interferon gamma Homo sapiens 55-58 1934174-3 1991 Electron-microscopic observation showed that the increased liposomal turbidity induced by IFN was due to liposomal aggregation, and the increased turbidity could be decreased by the addition of NaCl. Sodium Chloride 194-198 interferon gamma Homo sapiens 90-93 1909303-4 1991 We compared serum concentrations of IFN-gamma and neopterin (the biosynthesis of which is also inducible by IFN-gamma) with serum, tryptophan and kynurenine of 42 patients with HIV-1 infection. Neopterin 50-59 interferon gamma Homo sapiens 108-117 1909303-6 1991 Various significant correlations were found between tryptophan, kynurenine, IFN-gamma and neopterin concentrations. Neopterin 90-99 interferon gamma Homo sapiens 76-85 1909303-7 1991 Highest degree of correlation was found between neopterin, IFN-gamma and the kynurenine per tryptophan quotient which is the ratio between the product and the substrate concentration of IDO. Kynurenine 77-87 interferon gamma Homo sapiens 59-68 1909303-7 1991 Highest degree of correlation was found between neopterin, IFN-gamma and the kynurenine per tryptophan quotient which is the ratio between the product and the substrate concentration of IDO. Tryptophan 92-102 interferon gamma Homo sapiens 59-68 1709200-11 1991 IFN gamma treatment increased this binding by four-fold, PMA treatment resulted in a 50% increase in the number of IgG immune complexes bound, whereas vitamin D3 treated THP-1 cells bound half as many IgG immune complexes as control cells. Cholecalciferol 151-161 interferon gamma Homo sapiens 0-9 1827048-3 1991 However, when monocytes were pretreated with either CsA or CsH for 16 hr prior to the addition of IFN-gamma, HLA-DR expression was increased, probably because of a cyclosporin-induced increase in the number of IFN-gamma receptors. Cyclosporine 52-55 interferon gamma Homo sapiens 98-107 1827048-3 1991 However, when monocytes were pretreated with either CsA or CsH for 16 hr prior to the addition of IFN-gamma, HLA-DR expression was increased, probably because of a cyclosporin-induced increase in the number of IFN-gamma receptors. Cyclosporine 52-55 interferon gamma Homo sapiens 210-219 1827048-3 1991 However, when monocytes were pretreated with either CsA or CsH for 16 hr prior to the addition of IFN-gamma, HLA-DR expression was increased, probably because of a cyclosporin-induced increase in the number of IFN-gamma receptors. cyclosporin H 59-62 interferon gamma Homo sapiens 98-107 1827048-3 1991 However, when monocytes were pretreated with either CsA or CsH for 16 hr prior to the addition of IFN-gamma, HLA-DR expression was increased, probably because of a cyclosporin-induced increase in the number of IFN-gamma receptors. cyclosporin H 59-62 interferon gamma Homo sapiens 210-219 1827048-3 1991 However, when monocytes were pretreated with either CsA or CsH for 16 hr prior to the addition of IFN-gamma, HLA-DR expression was increased, probably because of a cyclosporin-induced increase in the number of IFN-gamma receptors. Cyclosporine 164-175 interferon gamma Homo sapiens 98-107 1827048-3 1991 However, when monocytes were pretreated with either CsA or CsH for 16 hr prior to the addition of IFN-gamma, HLA-DR expression was increased, probably because of a cyclosporin-induced increase in the number of IFN-gamma receptors. Cyclosporine 164-175 interferon gamma Homo sapiens 210-219 1827048-5 1991 IFN-alpha also inhibited the IFN-gamma-induced HLA-DR mRNA expression and showed synergy with CsA at low concentrations but not at high concentrations of the drugs. Cyclosporine 94-97 interferon gamma Homo sapiens 29-38 1901760-7 1991 The time required to reach 1.0 g for animals treated with nonspecific 90Y-MAb (ZME018) was significantly less either with (38.3 days) or without (34.4 days) IFN-gamma. zme018 79-85 interferon gamma Homo sapiens 157-166 1893073-4 1991 The association of IL-1-beta and TNF-alpha showed an additive effect on both parameters, whereas addition of IFN-gamma to either monokine reduced the proliferation and increased PGE2 release. Dinoprostone 178-182 interferon gamma Homo sapiens 109-118 1893073-5 1991 Incubation with a crude T cell supernatant or a mixture of cytokines including IL-1-beta, TNF-alpha and IFN-gamma enhanced synovial cell growth and PGE2 production as compared to the effect elicited by each single cytokine. Dinoprostone 148-152 interferon gamma Homo sapiens 104-113 1902486-0 1991 Stimulation of glycosaminoglycan accumulation by interferon gamma in cultured human retroocular fibroblasts. Glycosaminoglycans 15-32 interferon gamma Homo sapiens 49-65 1902486-2 1991 We treated cultured retroocular and dermal fibroblasts with recombinant interferon gamma (100 U/ml) for 16-24h and measured [3H]GAG accumulation. Tritium 125-127 interferon gamma Homo sapiens 72-88 1902486-2 1991 We treated cultured retroocular and dermal fibroblasts with recombinant interferon gamma (100 U/ml) for 16-24h and measured [3H]GAG accumulation. Glycosaminoglycans 128-131 interferon gamma Homo sapiens 72-88 1902486-5 1991 These results suggest that retroocular fibroblasts may be uniquely targeted for one action of interferon gamma which involves the modulation of GAG metabolism. Glycosaminoglycans 144-147 interferon gamma Homo sapiens 94-110 1901945-1 1991 Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages. Tetradecanoylphorbol Acetate 109-145 interferon gamma Homo sapiens 30-46 1902124-8 1991 Cycloheximide alone is also capable of inducing a rapid increase in class I transcription in both cell types, suggesting that constitutive attenuation of class I transcription may be a common phenomenon, and that IFN-gamma may act, in part, by interfering with such attenuation. Cycloheximide 0-13 interferon gamma Homo sapiens 213-222 1826725-8 1991 N-linked sugars may give structural stability to the IFN-gamma receptor and are unlikely to be directly involved in IFN-gamma binding. n-linked sugars 0-15 interferon gamma Homo sapiens 53-62 1901945-1 1991 Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages. Tetradecanoylphorbol Acetate 109-145 interferon gamma Homo sapiens 48-57 1901945-1 1991 Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages. Tetradecanoylphorbol Acetate 147-150 interferon gamma Homo sapiens 30-46 1901945-1 1991 Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages. Tetradecanoylphorbol Acetate 147-150 interferon gamma Homo sapiens 48-57 1901945-1 1991 Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages. Calcium 176-183 interferon gamma Homo sapiens 30-46 1901945-1 1991 Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages. Calcium 176-183 interferon gamma Homo sapiens 48-57 1901945-1 1991 Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages. Calcimycin 194-200 interferon gamma Homo sapiens 30-46 1901945-1 1991 Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages. Calcimycin 194-200 interferon gamma Homo sapiens 48-57 1901945-5 1991 However, IFN gamma decreased c-fos mRNA stability, as assessed by measuring the half-life of c-fos mRNA in actinomycin D-treated cells. Dactinomycin 107-120 interferon gamma Homo sapiens 9-18 1901945-6 1991 These results indicated that IFN gamma inhibited c-fos mRNA induction by TPA at the posttranscriptional level. Tetradecanoylphorbol Acetate 73-76 interferon gamma Homo sapiens 29-38 1903211-0 1991 Interferon-gamma enhances PAF-acether production by stimulated human polymorphonuclear leucocytes. Platelet Activating Factor 26-37 interferon gamma Homo sapiens 0-16 1903211-2 1991 The present study demonstrates that treatment of PMN with recombinant human interferon-gamma (IFN-gamma) significantly enhanced the production of PAF-acether by stimulated cells, in a concentration-dependent mode. Platelet Activating Factor 146-157 interferon gamma Homo sapiens 76-92 1903211-2 1991 The present study demonstrates that treatment of PMN with recombinant human interferon-gamma (IFN-gamma) significantly enhanced the production of PAF-acether by stimulated cells, in a concentration-dependent mode. Platelet Activating Factor 146-157 interferon gamma Homo sapiens 94-103 1901521-5 1991 Beads coated with K562 membranes stimulated LAK cells to release IFN-gamma and TNF-alpha. 5-Bromoisatin 18-22 interferon gamma Homo sapiens 65-74 1901424-4 1991 Sequence analysis showed complete identity with human thioredoxin, a dithiol reducing agent, implicated here in the IFN-gamma-mediated growth arrest of HeLa cells. dithiol 69-76 interferon gamma Homo sapiens 116-125 1673449-6 1991 Reversal of IFN-gamma"s ability to influence neuroblastoma cell growth as well as potentiate the anti-tumor effects of RA was obtained in the presence of an antibody against the IFN-gamma receptor, implying receptor-mediated physiological events. Tretinoin 119-121 interferon gamma Homo sapiens 12-21 1673449-6 1991 Reversal of IFN-gamma"s ability to influence neuroblastoma cell growth as well as potentiate the anti-tumor effects of RA was obtained in the presence of an antibody against the IFN-gamma receptor, implying receptor-mediated physiological events. Tretinoin 119-121 interferon gamma Homo sapiens 178-187 1901779-2 1991 We measured the in vitro production of interferon-gamma (IFN-gamma) in five cases of hyper-IgE syndrome (HIgE), induced by mitogens, calcium ionophores and phorbol ester. Calcium 133-140 interferon gamma Homo sapiens 39-55 1676283-4 1991 Furthermore, the defect in the phosphatidylinositol hydrolysis pathway in lymphocytes obtained from AIDS patients reverses after treatment with zidovudine, in parallel with improvements in phytohaemagglutinin-induced proliferative response and interferon-gamma production. Phosphatidylinositols 31-51 interferon gamma Homo sapiens 244-260 1676283-4 1991 Furthermore, the defect in the phosphatidylinositol hydrolysis pathway in lymphocytes obtained from AIDS patients reverses after treatment with zidovudine, in parallel with improvements in phytohaemagglutinin-induced proliferative response and interferon-gamma production. Zidovudine 144-154 interferon gamma Homo sapiens 244-260 1901779-2 1991 We measured the in vitro production of interferon-gamma (IFN-gamma) in five cases of hyper-IgE syndrome (HIgE), induced by mitogens, calcium ionophores and phorbol ester. Calcium 133-140 interferon gamma Homo sapiens 57-66 1849808-8 1991 Patients with positive gallium-67 uptake or bilateral hilar lymphadenopathy had high levels of either serum IFN-gamma or lysozyme. Gallium 23-30 interferon gamma Homo sapiens 108-117 1901779-2 1991 We measured the in vitro production of interferon-gamma (IFN-gamma) in five cases of hyper-IgE syndrome (HIgE), induced by mitogens, calcium ionophores and phorbol ester. Phorbol Esters 156-169 interferon gamma Homo sapiens 39-55 1901779-2 1991 We measured the in vitro production of interferon-gamma (IFN-gamma) in five cases of hyper-IgE syndrome (HIgE), induced by mitogens, calcium ionophores and phorbol ester. Phorbol Esters 156-169 interferon gamma Homo sapiens 57-66 1909137-5 1991 This effect was not beta cell specific since glucagon release and the number of alpha cells were also reduced in the cultures exposed to IFN-gamma plus TNF-alpha. Glucagon 45-53 interferon gamma Homo sapiens 137-146 1683236-2 1991 IgE production is preferentially induced by the T cell-derived lymphokine interleukin-4 (IL-4) and is suppressed by interferon and prostaglandins, of which interferon-gamma (IFN-gamma) is produced by T cells. Prostaglandins 131-145 interferon gamma Homo sapiens 156-172 1683236-2 1991 IgE production is preferentially induced by the T cell-derived lymphokine interleukin-4 (IL-4) and is suppressed by interferon and prostaglandins, of which interferon-gamma (IFN-gamma) is produced by T cells. Prostaglandins 131-145 interferon gamma Homo sapiens 174-183 1651364-0 1991 Interferon-gamma enhances superoxide production by HL-60 cells stimulated with multiple agonists. Superoxides 26-36 interferon gamma Homo sapiens 0-16 1649128-2 1991 Here, we demonstrate that amiloride neither inhibits the capability of IFN-gamma to activate the mononuclear phagocyte respiratory burst nor influences IFN-gamma induction of steady-state mRNA levels for 2 components of the superoxide anion-generating enzyme system. Amiloride 26-35 interferon gamma Homo sapiens 152-161 1649128-3 1991 On the contrary, we show that IFN-gamma-enhanced expression of the HLA-DR alpha gene is significantly inhibited by amiloride These data indicate that Na+/H+ antiporter stimulation by IFN-gamma is not involved in the mechanism of activation of macrophage oxidative metabolism. Amiloride 115-124 interferon gamma Homo sapiens 30-39 1651364-4 1991 IFN-gamma enhanced HL-60 cell superoxide production in response to F-Met-Leu-Phe (FMLP) in a concentration-dependent manner. Superoxides 30-40 interferon gamma Homo sapiens 0-9 1651364-5 1991 Following a 4-h exposure, an increase in O2- production was seen with IFN-gamma at 0.1 U/ml, with optimal priming at 100 U/ml. Superoxides 41-43 interferon gamma Homo sapiens 70-79 1651364-6 1991 The time course of priming by 100 U/ml IFN-gamma showed that at least a 1-h exposure was required, and a maximal effect was seen at 24 h. Priming after a 4-h exposure to 100 U/ml IFN-gamma was completely inhibited by 1 micrograms/ml cycloheximide. Cycloheximide 233-246 interferon gamma Homo sapiens 179-188 1651364-7 1991 HL-60 cells cultivated with 100 U/ml IFN-gamma produced increased O2- when exposed to 25 mM NaF (containing AIF4) or 10 nM phorbol myristate acetate, agonists that trigger the respiratory burst independent of receptor stimulation. Superoxides 66-68 interferon gamma Homo sapiens 37-46 1651364-7 1991 HL-60 cells cultivated with 100 U/ml IFN-gamma produced increased O2- when exposed to 25 mM NaF (containing AIF4) or 10 nM phorbol myristate acetate, agonists that trigger the respiratory burst independent of receptor stimulation. Sodium Fluoride 92-95 interferon gamma Homo sapiens 37-46 1651364-7 1991 HL-60 cells cultivated with 100 U/ml IFN-gamma produced increased O2- when exposed to 25 mM NaF (containing AIF4) or 10 nM phorbol myristate acetate, agonists that trigger the respiratory burst independent of receptor stimulation. Tetradecanoylphorbol Acetate 123-148 interferon gamma Homo sapiens 37-46 1908004-7 1991 However, when A23187 was added to high dose (1:120) PHA-stimulated cord blood MNCs IFN-gamma production increased to levels comparable with adult PHA-stimulated MNCs. Calcimycin 14-20 interferon gamma Homo sapiens 83-92 1848581-0 1991 Cyclic AMP synergy with Ca2+ for production of IFN-gamma by a cytolytic T cell clone is post-transcriptional. Cyclic AMP 0-10 interferon gamma Homo sapiens 47-56 1848581-1 1991 PGE2 or products increasing the intracellular concentration of cAMP (cAMP)i) had opposite effects on the induction of IFN-gamma in a CTL clone, depending on the inducing agent. Dinoprostone 0-4 interferon gamma Homo sapiens 118-127 1848581-3 1991 Low levels of IFN-gamma mRNA could be detected transiently after induction with ionomycin alone, whereas simultaneous induction with agents increasing (cAMP)i led to enhanced levels of IFN-gamma mRNA detectable up to 12 h. No IFN-gamma mRNA was detected when the CTL were activated with (cAMP)i-increasing agents alone or with PKC-activating agents such as PMA, suggesting that the transcriptional activation of the IFN-gamma gene was strictly dependent on the Ca2(+)-mediated and cyclosporin A-dependent event. Ionomycin 80-89 interferon gamma Homo sapiens 14-23 1848581-3 1991 Low levels of IFN-gamma mRNA could be detected transiently after induction with ionomycin alone, whereas simultaneous induction with agents increasing (cAMP)i led to enhanced levels of IFN-gamma mRNA detectable up to 12 h. No IFN-gamma mRNA was detected when the CTL were activated with (cAMP)i-increasing agents alone or with PKC-activating agents such as PMA, suggesting that the transcriptional activation of the IFN-gamma gene was strictly dependent on the Ca2(+)-mediated and cyclosporin A-dependent event. Cyclic AMP 152-156 interferon gamma Homo sapiens 185-194 1848581-3 1991 Low levels of IFN-gamma mRNA could be detected transiently after induction with ionomycin alone, whereas simultaneous induction with agents increasing (cAMP)i led to enhanced levels of IFN-gamma mRNA detectable up to 12 h. No IFN-gamma mRNA was detected when the CTL were activated with (cAMP)i-increasing agents alone or with PKC-activating agents such as PMA, suggesting that the transcriptional activation of the IFN-gamma gene was strictly dependent on the Ca2(+)-mediated and cyclosporin A-dependent event. Cyclic AMP 152-156 interferon gamma Homo sapiens 185-194 1848581-3 1991 Low levels of IFN-gamma mRNA could be detected transiently after induction with ionomycin alone, whereas simultaneous induction with agents increasing (cAMP)i led to enhanced levels of IFN-gamma mRNA detectable up to 12 h. No IFN-gamma mRNA was detected when the CTL were activated with (cAMP)i-increasing agents alone or with PKC-activating agents such as PMA, suggesting that the transcriptional activation of the IFN-gamma gene was strictly dependent on the Ca2(+)-mediated and cyclosporin A-dependent event. Cyclic AMP 152-156 interferon gamma Homo sapiens 185-194 1848581-4 1991 Analyses of IFN-gamma mRNA transcription by "run-on" experiments on nuclei isolated after activation of the CTL indicated that the Ca2+ signal alone induces maximal transcription of the IFN-gamma gene, which is not increased by either PKC activation or an increase in cAMP, but that further processing or stabilization of the IFN-gamma precursor or mature mRNA require an additional signal, provided either via a PKC or via a PKA activation pathway. Cyclic AMP 268-272 interferon gamma Homo sapiens 186-195 1848581-4 1991 Analyses of IFN-gamma mRNA transcription by "run-on" experiments on nuclei isolated after activation of the CTL indicated that the Ca2+ signal alone induces maximal transcription of the IFN-gamma gene, which is not increased by either PKC activation or an increase in cAMP, but that further processing or stabilization of the IFN-gamma precursor or mature mRNA require an additional signal, provided either via a PKC or via a PKA activation pathway. Cyclic AMP 268-272 interferon gamma Homo sapiens 186-195 1676485-2 1991 When cell-bound 125I-IFN gamma was cross-linked by disuccinimidyl suberate, the receptor-ligand complex migrated under nonreducing conditions as major bands of 155 kD and 90 kD and a minor band of 65-70 kD. disuccinimidyl 51-65 interferon gamma Homo sapiens 21-30 2005387-3 1991 Cytotoxicity of M phi activated by IFN-gamma plus LPS was detected in the presence of about 0.1 mM or more of L-arginine. Arginine 110-120 interferon gamma Homo sapiens 35-44 1900876-3 1991 The loss of 125I-labeled H-2Dd was retarded 75 to 90% by IFN-gamma whereas the biosynthetic rate was unaffected during the first 10-h culture. Iodine-125 12-16 interferon gamma Homo sapiens 57-66 1900876-3 1991 The loss of 125I-labeled H-2Dd was retarded 75 to 90% by IFN-gamma whereas the biosynthetic rate was unaffected during the first 10-h culture. h-2dd 25-30 interferon gamma Homo sapiens 57-66 1901275-0 1991 Interferon-gamma binds to heparan sulfate by a cluster of amino acids located in the C-terminal part of the molecule. Heparitin Sulfate 26-41 interferon gamma Homo sapiens 0-16 1706327-1 1991 A human colon-carcinoma cell subline resistant to doxorubicin (LoVo/Dx), previously shown to be more lysed than the chemosensitive subline LoVo/H by different immune effectors, is reported here to be similarly susceptible to direct, anti-proliferative effect of soluble cytokines (TNF-alpha and/or IFN-gamma). lovo 63-67 interferon gamma Homo sapiens 298-307 1901275-1 1991 Using three different approaches (domain mapping with monoclonal antibodies, limited enzymatic digestion and competition with synthetic peptides), we demonstrated that a cluster of basic amino acids on interferon-gamma is involved in its binding to heparan sulfate. Amino Acids, Basic 181-198 interferon gamma Homo sapiens 202-218 1901275-1 1991 Using three different approaches (domain mapping with monoclonal antibodies, limited enzymatic digestion and competition with synthetic peptides), we demonstrated that a cluster of basic amino acids on interferon-gamma is involved in its binding to heparan sulfate. Heparitin Sulfate 249-264 interferon gamma Homo sapiens 202-218 1901275-3 1991 Once bound to heparin sulfate, IFN-gamma is protected against protease attack. Heparitin Sulfate 14-29 interferon gamma Homo sapiens 31-40 1899359-0 1991 Induction of interferon-gamma by cord blood mononuclear cells is calcium dependent. Calcium 65-72 interferon gamma Homo sapiens 13-29 1825941-3 1991 Neopterin was shown to be produced by monocytes in response to stimulation with IFN-gamma, but not other cytokines. Neopterin 0-9 interferon gamma Homo sapiens 80-89 1825941-5 1991 It therefore appears that cytokines may generate neopterin by induction of IFN-gamma, by synergy with low levels of induced IFN-gamma, or by non-IFN-gamma-dependent mechanisms. Neopterin 49-58 interferon gamma Homo sapiens 75-84 1847861-5 1991 IFN gamma-induced RT1.B expression was not inhibited by either 10 nM to 100 microM 1-(5-isoquinolysulfonyl)-2-methylpiperazine or 200 nM to 200 microM 8-(N,N-dimethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride. 8-(n,n-dimethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride 151-216 interferon gamma Homo sapiens 0-9 1847861-7 1991 However, 0.01-10 micrograms/ml cycloheximide inhibited IFN gamma-induced RT1.B antigen expression in a dose-dependent manner. Cycloheximide 31-44 interferon gamma Homo sapiens 55-64 1900229-7 1991 On the other hand, the follicles cultured with IFN gamma showed poor response to TSH. Thyrotropin 81-84 interferon gamma Homo sapiens 47-56 1900229-8 1991 Thus, IFN gamma induced the expression of MHC class II antigens of cultured thyroid follicles and inhibited TSH-induced morphological changes in the cells. Thyrotropin 108-111 interferon gamma Homo sapiens 6-15 1851508-3 1991 Monocytes from leprosy patients receiving prednisone therapy responded to lower concentrations of IFN-gamma in vitro with enhanced superoxide anion release when challenged with M. leprae or M. bovis BCG than did monocytes from healthy subjects and other leprosy patients. Prednisone 42-52 interferon gamma Homo sapiens 98-107 1851508-3 1991 Monocytes from leprosy patients receiving prednisone therapy responded to lower concentrations of IFN-gamma in vitro with enhanced superoxide anion release when challenged with M. leprae or M. bovis BCG than did monocytes from healthy subjects and other leprosy patients. Superoxides 131-147 interferon gamma Homo sapiens 98-107 1851508-4 1991 Although the number of patients was small and the population heterogeneous, the data suggested that prednisone could alter IFN-gamma efficacy and led to the examination of the effect of glucocorticosteroids on IFN-gamma activation of monocytes. Prednisone 100-110 interferon gamma Homo sapiens 123-132 1851508-5 1991 IFN-gamma treatment following in vitro dexamethasone pretreatment of monocytes from healthy subjects resulted in a greater enhancement of superoxide anion generation than that observed with IFN-gamma treatment alone. Dexamethasone 39-52 interferon gamma Homo sapiens 0-9 1851508-5 1991 IFN-gamma treatment following in vitro dexamethasone pretreatment of monocytes from healthy subjects resulted in a greater enhancement of superoxide anion generation than that observed with IFN-gamma treatment alone. Superoxides 138-154 interferon gamma Homo sapiens 0-9 1899359-4 1991 Supernatants from PHA-stimulated adult macrophages and phorbol myristate acetate (PMA)-stimulated U937 cells (which were dialyzed prior to culture to remove PMA) increased IFN-gamma production in neonatal PHA-stimulated MNC (14 to 217 units/ml and 14 to 293 units/ml, respectively). Tetradecanoylphorbol Acetate 55-80 interferon gamma Homo sapiens 172-181 1899359-4 1991 Supernatants from PHA-stimulated adult macrophages and phorbol myristate acetate (PMA)-stimulated U937 cells (which were dialyzed prior to culture to remove PMA) increased IFN-gamma production in neonatal PHA-stimulated MNC (14 to 217 units/ml and 14 to 293 units/ml, respectively). Tetradecanoylphorbol Acetate 82-85 interferon gamma Homo sapiens 172-181 1899359-4 1991 Supernatants from PHA-stimulated adult macrophages and phorbol myristate acetate (PMA)-stimulated U937 cells (which were dialyzed prior to culture to remove PMA) increased IFN-gamma production in neonatal PHA-stimulated MNC (14 to 217 units/ml and 14 to 293 units/ml, respectively). Tetradecanoylphorbol Acetate 157-160 interferon gamma Homo sapiens 172-181 1899359-6 1991 The increase in IFN-gamma production by exogenous CaCl2 was blocked by the addition of the calcium channel blocker, manganese chloride (MnCl2). Calcium Chloride 50-55 interferon gamma Homo sapiens 16-25 1705283-0 1991 Human recombinant interferon gamma enhances neonatal polymorphonuclear leukocyte activation and movement, and increases free intracellular calcium. Calcium 139-146 interferon gamma Homo sapiens 18-34 1899359-6 1991 The increase in IFN-gamma production by exogenous CaCl2 was blocked by the addition of the calcium channel blocker, manganese chloride (MnCl2). manganese chloride 116-134 interferon gamma Homo sapiens 16-25 1899359-6 1991 The increase in IFN-gamma production by exogenous CaCl2 was blocked by the addition of the calcium channel blocker, manganese chloride (MnCl2). manganese chloride 136-141 interferon gamma Homo sapiens 16-25 1899359-7 1991 Furthermore, the increased IFN-gamma production by PHA-stimulated cord blood MNC in the presence of PHA-stimulated adult macrophage supernatant or PMA-stimulated U937 supernatant was abrogated by the addition of MnCl2, chlorpromazine, and verapamil. Tetradecanoylphorbol Acetate 147-150 interferon gamma Homo sapiens 27-36 1899359-7 1991 Furthermore, the increased IFN-gamma production by PHA-stimulated cord blood MNC in the presence of PHA-stimulated adult macrophage supernatant or PMA-stimulated U937 supernatant was abrogated by the addition of MnCl2, chlorpromazine, and verapamil. manganese chloride 212-217 interferon gamma Homo sapiens 27-36 1899359-7 1991 Furthermore, the increased IFN-gamma production by PHA-stimulated cord blood MNC in the presence of PHA-stimulated adult macrophage supernatant or PMA-stimulated U937 supernatant was abrogated by the addition of MnCl2, chlorpromazine, and verapamil. Chlorpromazine 219-233 interferon gamma Homo sapiens 27-36 1899359-7 1991 Furthermore, the increased IFN-gamma production by PHA-stimulated cord blood MNC in the presence of PHA-stimulated adult macrophage supernatant or PMA-stimulated U937 supernatant was abrogated by the addition of MnCl2, chlorpromazine, and verapamil. Verapamil 239-248 interferon gamma Homo sapiens 27-36 1899359-8 1991 These data suggested that the soluble factor produced by PHA-stimulated adult macrophage supernatant and PHA-stimulated U937 supernatant induced IFN-gamma production in PHA-stimulated cord blood MNC by inducing calcium-dependent signals at more than one site. Calcium 211-218 interferon gamma Homo sapiens 145-154 1847167-4 1991 As positive controls, IFN-gamma and LPS also primed both human and porcine PMN for enhanced O2- release. Superoxides 92-94 interferon gamma Homo sapiens 22-31 1900310-7 1991 Furthermore, the carboxy-terminal part of the interferon-gamma molecule contains an amino acid cluster, very closely related to a consensus sequence, present in more than 20 proteins known to bind sulfated glycosaminoglycans such as heparin. Glycosaminoglycans 206-224 interferon gamma Homo sapiens 46-62 1900310-7 1991 Furthermore, the carboxy-terminal part of the interferon-gamma molecule contains an amino acid cluster, very closely related to a consensus sequence, present in more than 20 proteins known to bind sulfated glycosaminoglycans such as heparin. Heparin 233-240 interferon gamma Homo sapiens 46-62 1847718-6 1991 Superoxide release in IFN-gamma-activated cells was stimulated with f-Met-Leu-Phe, C5a, or PMA. Superoxides 0-10 interferon gamma Homo sapiens 22-31 1847718-6 1991 Superoxide release in IFN-gamma-activated cells was stimulated with f-Met-Leu-Phe, C5a, or PMA. N-Formylmethionine Leucyl-Phenylalanine 68-81 interferon gamma Homo sapiens 22-31 1674419-7 1991 Large amounts of neopterin are released by human macrophages on stimulation with interferon-gamma (IFN gamma), and tumor necrosis factor alpha (TNF alpha) further enhances the effect of IFN gamma. Neopterin 17-26 interferon gamma Homo sapiens 81-97 1899864-10 1991 This IFN-gamma induced factor also binds to an oligonucleotide corresponding to -91 to -62 bp of the interferon-beta (IFN-beta) gene promoter, a region necessary for the induction of the IFN-beta gene by virus and double-stranded RNA. Oligonucleotides 47-62 interferon gamma Homo sapiens 5-14 1997000-1 1991 In this study we analyse the effects of the anti-tumor compound distamycin on the binding of nuclear factor(s) to a synthetic oligonucleotide (GTATA/IFN-gamma) mimicking a putative regulatory region of the human HLA-DR alpha gene. stallimycin 64-74 interferon gamma Homo sapiens 149-158 1997000-1 1991 In this study we analyse the effects of the anti-tumor compound distamycin on the binding of nuclear factor(s) to a synthetic oligonucleotide (GTATA/IFN-gamma) mimicking a putative regulatory region of the human HLA-DR alpha gene. Oligonucleotides 126-141 interferon gamma Homo sapiens 149-158 1674419-7 1991 Large amounts of neopterin are released by human macrophages on stimulation with interferon-gamma (IFN gamma), and tumor necrosis factor alpha (TNF alpha) further enhances the effect of IFN gamma. Neopterin 17-26 interferon gamma Homo sapiens 99-108 1674419-7 1991 Large amounts of neopterin are released by human macrophages on stimulation with interferon-gamma (IFN gamma), and tumor necrosis factor alpha (TNF alpha) further enhances the effect of IFN gamma. Neopterin 17-26 interferon gamma Homo sapiens 186-195 1824688-3 1991 The latter was achieved by analyzing, respectively, the superinduction of IL-2 and IFN-gamma mRNA occurring upon culture with cycloheximide or after low-dose gamma-irradiation. Cycloheximide 126-139 interferon gamma Homo sapiens 83-92 1824688-7 1991 In cells from trisomic subjects, superinduction of IFN-gamma mRNA by cycloheximide was at least as extensive as for normal donors, while in the case of IL-2 mRNA, it was weaker. Cycloheximide 69-82 interferon gamma Homo sapiens 51-60 1846325-12 1991 However, a rise of cAMP modulates in an opposite fashion the Ly-6E-inducing actions of IFN-gamma and IFN-alpha/beta, which suggests that the two types of IFN utilize separate biochemical pathways to regulate Ly-6E expression. Cyclic AMP 19-23 interferon gamma Homo sapiens 87-96 1899071-9 1991 Interferon-gamma decreased the ratio of surface to filamentous globoside staining, but had the opposite effect on GM3 distribution. gm3 114-117 interferon gamma Homo sapiens 0-16 1899098-7 1991 However, when differentiation was induced in these cells by TPA or IFN-gamma, the additive effect of TNF-alpha on the IFN-gamma induced DR expression was eliminated. Tetradecanoylphorbol Acetate 60-63 interferon gamma Homo sapiens 118-127 1903142-0 1991 Upregulation of interferon-gamma binding by tumor necrosis factor and lymphotoxin: disparate potencies of the cytokines and modulation of their effects by phorbol ester. Phorbol Esters 155-168 interferon gamma Homo sapiens 16-32 1903142-11 1991 Further, the TPA-induced attenuation of IFN-gamma receptor upregulation suggests that protein kinase C activation can regulate the TNF/LT-mediated pathways involved in IFN-gamma receptor upregulation. Tetradecanoylphorbol Acetate 13-16 interferon gamma Homo sapiens 40-49 1903142-11 1991 Further, the TPA-induced attenuation of IFN-gamma receptor upregulation suggests that protein kinase C activation can regulate the TNF/LT-mediated pathways involved in IFN-gamma receptor upregulation. Tetradecanoylphorbol Acetate 13-16 interferon gamma Homo sapiens 168-177 1899122-8 1991 However, the combination of interferon gamma plus suramin (30 microM) induced less inhibition of proliferation than did interferon gamma alone. Suramin 50-57 interferon gamma Homo sapiens 120-136 1703684-0 1991 In vivo regulation of cytokine expression: effects of cycloheximide and cyclosporine (CyA) on IFN-gamma and TNF-alpha expression. Cyclosporine 72-84 interferon gamma Homo sapiens 94-103 1835259-3 1991 This effect is inhibited by cyclosporin A and by anti-IFN-gamma mAbs and is restored by adding exogenous recombinant IFN-gamma tb CsA treated cells. Cyclosporine 28-41 interferon gamma Homo sapiens 117-126 1703684-0 1991 In vivo regulation of cytokine expression: effects of cycloheximide and cyclosporine (CyA) on IFN-gamma and TNF-alpha expression. Cyclosporine 86-89 interferon gamma Homo sapiens 94-103 1994545-1 1991 It is known that 1,25(OH)2D3 inhibits IL-2, IFN-gamma, and GM-CSF mRNA accumulation in activated T cells. Calcitriol 17-28 interferon gamma Homo sapiens 44-53 1899803-4 1991 Staining with anti-poly(ADP-ribose) antibodies and purification of ADP-ribosylated nuclear proteins by affinity chromatography over boronate agarose showed that enhancement of poly(ADP-ribose) polymerase activity by IFN-gamma was accompanied by accumulation of poly(ADP-ribose) polymers in nuclear proteins. boronate agarose 132-148 interferon gamma Homo sapiens 216-225 1899803-4 1991 Staining with anti-poly(ADP-ribose) antibodies and purification of ADP-ribosylated nuclear proteins by affinity chromatography over boronate agarose showed that enhancement of poly(ADP-ribose) polymerase activity by IFN-gamma was accompanied by accumulation of poly(ADP-ribose) polymers in nuclear proteins. Poly Adenosine Diphosphate Ribose 19-35 interferon gamma Homo sapiens 216-225 1722946-3 1991 Intracellular growth of Toxoplasma gondii and Chlamydia psittaci in human fibroblasts in vitro is inhibited by IFN-gamma and this inhibition is negated by extra Trp in the medium. Tryptophan 161-164 interferon gamma Homo sapiens 111-120 1722946-5 1991 Thus, in some in vitro systems, antiproliferative effects of IFN-gamma are mediated by induced depletion of Trp. Tryptophan 108-111 interferon gamma Homo sapiens 61-70 1835259-3 1991 This effect is inhibited by cyclosporin A and by anti-IFN-gamma mAbs and is restored by adding exogenous recombinant IFN-gamma tb CsA treated cells. Cyclosporine 130-133 interferon gamma Homo sapiens 54-63 1835259-3 1991 This effect is inhibited by cyclosporin A and by anti-IFN-gamma mAbs and is restored by adding exogenous recombinant IFN-gamma tb CsA treated cells. Cyclosporine 130-133 interferon gamma Homo sapiens 117-126 1898846-8 1991 In addition, the patients who had cleared completely while receiving steroids and remained in remission had significantly higher pretreatment serum IFNg levels than did those with incomplete resolution of parenchymal shadows or radiographic relapses (p less than 0.05). Steroids 69-77 interferon gamma Homo sapiens 148-152 1898840-3 1991 Using the tumor target cell survival (TTCS) assay, concentrations of halothane from 0.5 to 2% markedly augmented the antitumor activities of IFN-gamma against HT-29. Halothane 69-78 interferon gamma Homo sapiens 141-150 1898840-4 1991 The tumor cell cytostatic effects of IFN-gamma in the 0.75-6-unit/ml range were increased nearly 400% by concentrations of halothane as low as 1%. Halothane 123-132 interferon gamma Homo sapiens 37-46 1898840-5 1991 These results were confirmed in a separate cytolytic assay (Indium-111 release assay), which revealed that halothane concentrations in the 2-4% range markedly increased the cytolytic capacity of IFN-gamma at doses of IFN-gamma between 75 and 1,250 units/ml. Indium 60-66 interferon gamma Homo sapiens 195-204 1898840-5 1991 These results were confirmed in a separate cytolytic assay (Indium-111 release assay), which revealed that halothane concentrations in the 2-4% range markedly increased the cytolytic capacity of IFN-gamma at doses of IFN-gamma between 75 and 1,250 units/ml. Halothane 107-116 interferon gamma Homo sapiens 195-204 1898840-5 1991 These results were confirmed in a separate cytolytic assay (Indium-111 release assay), which revealed that halothane concentrations in the 2-4% range markedly increased the cytolytic capacity of IFN-gamma at doses of IFN-gamma between 75 and 1,250 units/ml. Halothane 107-116 interferon gamma Homo sapiens 217-226 1898840-6 1991 The cytolytic activity of IFN-gamma was increased nearly 300% by doses of halothane as low as 1%. Halothane 74-83 interferon gamma Homo sapiens 26-35 1898840-7 1991 A nearly identical pattern of augmentation of IFN-gamma-induced antitumor activity was observed when the known calmodulin inhibitor trifluoperazine (TFP) was coincubated with IFN-gamma. Trifluoperazine 132-147 interferon gamma Homo sapiens 46-55 1898840-7 1991 A nearly identical pattern of augmentation of IFN-gamma-induced antitumor activity was observed when the known calmodulin inhibitor trifluoperazine (TFP) was coincubated with IFN-gamma. Trifluoperazine 132-147 interferon gamma Homo sapiens 175-184 1898840-7 1991 A nearly identical pattern of augmentation of IFN-gamma-induced antitumor activity was observed when the known calmodulin inhibitor trifluoperazine (TFP) was coincubated with IFN-gamma. Trifluoperazine 149-152 interferon gamma Homo sapiens 46-55 1898840-7 1991 A nearly identical pattern of augmentation of IFN-gamma-induced antitumor activity was observed when the known calmodulin inhibitor trifluoperazine (TFP) was coincubated with IFN-gamma. Trifluoperazine 149-152 interferon gamma Homo sapiens 175-184 1898840-9 1991 These observations suggest that the pattern of halothane potentiation of the antitumor activity of IFN-gamma is similar to that exhibited by known calmodulin inhibitors. Halothane 47-56 interferon gamma Homo sapiens 99-108 1804048-0 1991 Effects of some lipophilic carboxylic acid on release of interferon gamma from the human peripheral blood leukocytes. Carboxylic Acids 27-42 interferon gamma Homo sapiens 57-73 1906254-6 1991 Loss of radioiodinated H-2Dd from the cell surface was diminished by 75-90% at 12 h in tests of lymphocytes continuously cultured with IFN-gamma (compared to control, p less than 0.05). CHEMBL200255 25-28 interferon gamma Homo sapiens 135-144 1902078-5 1991 Indomethacin enhanced IFN-gamma release and spontaneous and induced TNF-alpha secretion in all groups but stimulated IL-1 only in irradiated patients. Indomethacin 0-12 interferon gamma Homo sapiens 22-31 1932512-8 1991 Interferon-gamma treatment caused an increase in serum concentrations of soluble HLA-DR molecules, whereas a decrease of circulating HLA-DR molecules was associated with an immunosuppressive with cyclosporine A. Cyclosporine 196-210 interferon gamma Homo sapiens 0-16 1675571-5 1991 The adherent IFN gamma-treated cells generated more O2- than the nonadherent IFN gamma-treated cells by the stimulation with fMLP. Superoxides 52-54 interferon gamma Homo sapiens 13-22 1675571-7 1991 Azelastine (A-5610, CAS 58581-89-8) significantly inhibited the O2- generation from the adherent IFN gamma-treated U937 cells stimulated by fMLP or PMA in a dose-dependent manner. azelastine 0-10 interferon gamma Homo sapiens 97-106 1675571-7 1991 Azelastine (A-5610, CAS 58581-89-8) significantly inhibited the O2- generation from the adherent IFN gamma-treated U937 cells stimulated by fMLP or PMA in a dose-dependent manner. Superoxides 64-66 interferon gamma Homo sapiens 97-106 1910954-9 1991 Carbetimer did not stimulate TNF-alpha release from isolated normal human monocytes or lymphocytes, but it markedly inhibited T-lymphocyte production of IFN-gamma, which became undetectable at a concentration of 1 mg of Carbetimer/ml. carboxyimamidate 0-10 interferon gamma Homo sapiens 153-162 1786201-3 1991 OK-MC produce several kinds of cytokines such as interferon alpha (IFN alpha), IFN gamma, and tumor growth inhibitory factor (TGIF) both in vitro and in vivo. ok-mc 0-5 interferon gamma Homo sapiens 79-88 1910954-9 1991 Carbetimer did not stimulate TNF-alpha release from isolated normal human monocytes or lymphocytes, but it markedly inhibited T-lymphocyte production of IFN-gamma, which became undetectable at a concentration of 1 mg of Carbetimer/ml. carboxyimamidate 220-230 interferon gamma Homo sapiens 153-162 1910954-10 1991 In summary, Carbetimer-induced hypercalcemia appears to be due to a direct stimulation of osteolysis, but possibly also to an inhibition of IFN-gamma production. carboxyimamidate 12-22 interferon gamma Homo sapiens 140-149 1782638-2 1991 Neopterin is produced chiefly by human macrophages through their activation by T-cell-derived interferon gamma. Neopterin 0-9 interferon gamma Homo sapiens 94-110 1900217-3 1991 In order to evaluate further possible mechanisms of Ciamexone it was the aim of our investigation to study its influence on interferon gamma (IFN gamma) production in phytohaemogglutinin (PHA)-stimulated T lymphocytes of 15 tumour patients and 12 healthy reference subjects. ciamexon 52-61 interferon gamma Homo sapiens 124-151 1905580-2 1991 Recently, we have demonstrated that a synthetic 17 amino acid peptide (CKS-17*) homologous to a highly conserved region in the transmembrane portion of the envelope of several human or animal retroviruses suppresses the production of human interferon-gamma (IFN gamma) by human peripheral blood leukocytes (PBL). 17 amino acid peptide 48-69 interferon gamma Homo sapiens 240-256 1900217-7 1991 The influence of hydrocortisone on the stimulation of PBMC with PHA resulted in a dose-dependent suppression of IFN gamma production in both test groups, again with significant differences between them. Hydrocortisone 17-31 interferon gamma Homo sapiens 112-121 1900217-8 1991 The IFN gamma concentration was 0.95 ng/ml in the reference group and 0.2 ng/ml in the tumour patients when 0.01 micrograms/ml hydrocortisone was added (P less than 0.05). Hydrocortisone 127-141 interferon gamma Homo sapiens 4-13 1900217-9 1991 At 10 micrograms/ml hydrocortisone suppressed IFN gamma production completely in both groups. Hydrocortisone 20-34 interferon gamma Homo sapiens 46-55 1905580-2 1991 Recently, we have demonstrated that a synthetic 17 amino acid peptide (CKS-17*) homologous to a highly conserved region in the transmembrane portion of the envelope of several human or animal retroviruses suppresses the production of human interferon-gamma (IFN gamma) by human peripheral blood leukocytes (PBL). 17 amino acid peptide 48-69 interferon gamma Homo sapiens 258-267 1934005-1 1991 Heparan sulfate and heparin, new targets for IFN-gamma, protect, relax the cytokine and regulate its activity. Heparitin Sulfate 0-15 interferon gamma Homo sapiens 45-54 1934005-1 1991 Heparan sulfate and heparin, new targets for IFN-gamma, protect, relax the cytokine and regulate its activity. Heparin 20-27 interferon gamma Homo sapiens 45-54 1934005-4 1991 This specific group of amino acid is also involved in the binding of interferon-gamma to basement membrane or cell surface heparan sulfate. Heparitin Sulfate 123-138 interferon gamma Homo sapiens 69-85 1934005-5 1991 Once bound to heparan sulfate, interferon-gamma is protected from proteolytic cleavage and it is suggested that the protein folds in a new relaxed conformation, with increased stability. Heparitin Sulfate 14-29 interferon gamma Homo sapiens 31-47 1834724-1 1991 We investigated the effects of nicotinamide and 3-aminobenzamide, known as inhibitors of poly (ADP-ribose) synthetase, on the expression of interferon- gamma (IFN-gamma)-induced class I and II major histocompatibility complex (MHC) molecules on the surface of cultured human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF). Niacinamide 31-43 interferon gamma Homo sapiens 159-168 1834724-1 1991 We investigated the effects of nicotinamide and 3-aminobenzamide, known as inhibitors of poly (ADP-ribose) synthetase, on the expression of interferon- gamma (IFN-gamma)-induced class I and II major histocompatibility complex (MHC) molecules on the surface of cultured human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF). 3-aminobenzamide 48-64 interferon gamma Homo sapiens 159-168 1834724-5 1991 Nicotinamide and 3-aminobenzamide in the concentration greater than or equal to 1 mM reduced the IFN- gamma -induced expression of HLA-DR and HLA-DP on both HUVEC and HDF, whereas neither agent in the concentration of up to 10 mM affected the IFN- gamma -induced increase in HLA-A,B,C molecule expression. Niacinamide 0-12 interferon gamma Homo sapiens 97-107 1834724-5 1991 Nicotinamide and 3-aminobenzamide in the concentration greater than or equal to 1 mM reduced the IFN- gamma -induced expression of HLA-DR and HLA-DP on both HUVEC and HDF, whereas neither agent in the concentration of up to 10 mM affected the IFN- gamma -induced increase in HLA-A,B,C molecule expression. Niacinamide 0-12 interferon gamma Homo sapiens 243-253 1834724-5 1991 Nicotinamide and 3-aminobenzamide in the concentration greater than or equal to 1 mM reduced the IFN- gamma -induced expression of HLA-DR and HLA-DP on both HUVEC and HDF, whereas neither agent in the concentration of up to 10 mM affected the IFN- gamma -induced increase in HLA-A,B,C molecule expression. 3-aminobenzamide 17-33 interferon gamma Homo sapiens 97-107 1834724-5 1991 Nicotinamide and 3-aminobenzamide in the concentration greater than or equal to 1 mM reduced the IFN- gamma -induced expression of HLA-DR and HLA-DP on both HUVEC and HDF, whereas neither agent in the concentration of up to 10 mM affected the IFN- gamma -induced increase in HLA-A,B,C molecule expression. 3-aminobenzamide 17-33 interferon gamma Homo sapiens 243-253 1761362-2 1991 Sizofiran alone in culture and in combination with HBV Ag was found to enhance IFN-gamma production and the proliferative response of PBMC from the patients compared with corresponding medium or HBV Ag alone culture. Sizofiran 0-9 interferon gamma Homo sapiens 79-88 1840028-8 1991 In addition, following stimulation with phytohemagglutinin (PHA) and phorbol 12-myristate 13-acetate (or PHA alone) all clones released interferon-gamma and tumour necrosis factor-alpha, but not IL-2. Tetradecanoylphorbol Acetate 69-100 interferon gamma Homo sapiens 136-185 1907761-0 1991 Role of prostaglandin E2 on defective interferon-gamma production during type B acute viral hepatitis. Dinoprostone 8-24 interferon gamma Homo sapiens 38-54 1667651-3 1991 Concentrations of THC and CBD, comparable to plasma levels found after smoking marijuana (10-100 ng/ml), increased the concentration of measurable IFN (139 and 68%), while high concentrations of both cannabinoids (5-20 micrograms/ml) completely blocked synthesis and/or release of this cytokine. Dronabinol 18-21 interferon gamma Homo sapiens 147-150 1667651-3 1991 Concentrations of THC and CBD, comparable to plasma levels found after smoking marijuana (10-100 ng/ml), increased the concentration of measurable IFN (139 and 68%), while high concentrations of both cannabinoids (5-20 micrograms/ml) completely blocked synthesis and/or release of this cytokine. Cannabidiol 26-29 interferon gamma Homo sapiens 147-150 1845802-1 1991 PGE2 is known to inhibit IL-2 and IFN-gamma production from Th cells and is widely viewed as a general immunosuppressant. Dinoprostone 0-4 interferon gamma Homo sapiens 34-43 1883524-4 1991 As a consequence, large amounts of neopterin are formed during IFN-gamma-triggered synthesis of tetrahydrobiopterin. Neopterin 35-44 interferon gamma Homo sapiens 63-72 1883524-4 1991 As a consequence, large amounts of neopterin are formed during IFN-gamma-triggered synthesis of tetrahydrobiopterin. sapropterin 96-115 interferon gamma Homo sapiens 63-72 1909141-5 1991 IFN-gamma provides the first signal for the production of nitric oxide (NO), the effector molecule for intracellular destruction of parasites. Nitric Oxide 58-70 interferon gamma Homo sapiens 0-9 1789988-6 1991 In addition, ciclosporin blocked the interferon-gamma-induced increase in epidermal 12(S)-HETE binding. Cyclosporine 13-24 interferon gamma Homo sapiens 37-53 1789988-6 1991 In addition, ciclosporin blocked the interferon-gamma-induced increase in epidermal 12(S)-HETE binding. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 84-94 interferon gamma Homo sapiens 37-53 1837465-4 1991 Like CsA, Ro 14-6113 inhibited the mitogen- or alloantigen-induced proliferation of T cells as well as their capacity to secrete interleukin-2 (IL-2), interferon-gamma and tumor necrosis factor alpha. Ro 14-6113 10-20 interferon gamma Homo sapiens 151-199 1907761-5 1991 A statistically significant correlation was found only in control group between IFN-gamma and PGE2 levels in unstimulated cultures. Dinoprostone 94-98 interferon gamma Homo sapiens 80-89 2175266-0 1990 Regulation of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) binding sites on human epidermal cells by interferon-gamma. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 14-48 interferon gamma Homo sapiens 104-120 2176110-2 1990 Previously we have shown that a single in vivo treatment of selected X-CGD patients with interferon-gamma (INF-gamma) resulted 14 days later in near-normal levels of superoxide generation by phagocytes. Superoxides 166-176 interferon gamma Homo sapiens 89-105 2176110-2 1990 Previously we have shown that a single in vivo treatment of selected X-CGD patients with interferon-gamma (INF-gamma) resulted 14 days later in near-normal levels of superoxide generation by phagocytes. Superoxides 166-176 interferon gamma Homo sapiens 107-116 2176110-7 1990 By contrast, colonies derived 7 days after a single INF-gamma injection were able to generate superoxide as shown by increased NBT reduction. Superoxides 94-104 interferon gamma Homo sapiens 52-61 2176110-7 1990 By contrast, colonies derived 7 days after a single INF-gamma injection were able to generate superoxide as shown by increased NBT reduction. Nitroblue Tetrazolium 127-130 interferon gamma Homo sapiens 52-61 2147939-0 1990 Rapid increase of the human IFN-gamma receptor phosphorylation in response to human IFN-gamma and phorbol myristate acetate. Tetradecanoylphorbol Acetate 98-123 interferon gamma Homo sapiens 28-37 2147939-6 1990 Phosphoamino acid analysis by TLC showed that the same amino acids, serine and threonine, are phosphorylated at a basal level and after incubation with hu-IFN-gamma. Phosphoamino Acids 0-17 interferon gamma Homo sapiens 155-164 2147939-6 1990 Phosphoamino acid analysis by TLC showed that the same amino acids, serine and threonine, are phosphorylated at a basal level and after incubation with hu-IFN-gamma. Serine 68-74 interferon gamma Homo sapiens 155-164 2147939-6 1990 Phosphoamino acid analysis by TLC showed that the same amino acids, serine and threonine, are phosphorylated at a basal level and after incubation with hu-IFN-gamma. Threonine 79-88 interferon gamma Homo sapiens 155-164 2147939-12 1990 But the protein kinase C inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7) and staurosporine, reduced this IFN-gamma-induced expression. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 37-83 interferon gamma Homo sapiens 121-130 2147939-12 1990 But the protein kinase C inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7) and staurosporine, reduced this IFN-gamma-induced expression. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 85-87 interferon gamma Homo sapiens 121-130 2147939-12 1990 But the protein kinase C inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7) and staurosporine, reduced this IFN-gamma-induced expression. Staurosporine 93-106 interferon gamma Homo sapiens 121-130 2131048-7 1990 The combination of TNF and IFN-gamma enhanced cytotoxicity about 20-fold for DX and 6-fold for CDDP, evaluated in terms of the modification index, against LoVo/DX and U20S/Pt cells respectively. cddp 95-99 interferon gamma Homo sapiens 27-36 2147950-4 1990 Induced cell death is inhibited by cyclosporin A and by anti-interferon gamma (IFN-gamma), and is restored by adding exogenous recombinant IFN-gamma to cyclosporin A-treated cells. Cyclosporine 152-165 interferon gamma Homo sapiens 79-88 2147950-4 1990 Induced cell death is inhibited by cyclosporin A and by anti-interferon gamma (IFN-gamma), and is restored by adding exogenous recombinant IFN-gamma to cyclosporin A-treated cells. Cyclosporine 152-165 interferon gamma Homo sapiens 139-148 2128302-3 1990 Tryptophan concentrations correlated negatively to neopterin concentrations, and serum neopterin concentrations correlated positively to IFN-gamma concentrations. Neopterin 87-96 interferon gamma Homo sapiens 137-146 2128302-5 1990 From the data it appears that reduced tryptophan in patients may result from induction of indoleamine (2,3)-dioxygenase by IFN-gamma. Tryptophan 38-48 interferon gamma Homo sapiens 123-132 2128302-5 1990 From the data it appears that reduced tryptophan in patients may result from induction of indoleamine (2,3)-dioxygenase by IFN-gamma. indolamine 90-101 interferon gamma Homo sapiens 123-132 2258640-9 1990 This is in accord with in vitro studies showing that, while interferons alpha and beta decrease production of glycosaminoglycans, IFN-gamma increases production of glycosaminoglycans. Glycosaminoglycans 164-182 interferon gamma Homo sapiens 130-139 2175266-0 1990 Regulation of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) binding sites on human epidermal cells by interferon-gamma. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 50-60 interferon gamma Homo sapiens 104-120 2175266-6 1990 The up-regulation of 12(S)-HETE receptors by IFN-gamma may represent an amplification mechanism of the assumed role of 12(S)-HETE in skin wound repair. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 21-31 interferon gamma Homo sapiens 45-54 2123552-1 1990 The interferon gamma (IFN-gamma) response region of the human class II major histocompatibility complex gene, DPA, has been localized to a 52-base-pair (bp) DNA fragment in the proximal promotor at -107 to -55 bp after transfection into HeLa cells of a series of 5", 3", and gap deletion mutants linked to a reporter gene, human growth hormone, as well as of synthetic oligonucleotides fused to the heterologous promoter thymidine kinase. dpa 110-113 interferon gamma Homo sapiens 4-31 2123552-1 1990 The interferon gamma (IFN-gamma) response region of the human class II major histocompatibility complex gene, DPA, has been localized to a 52-base-pair (bp) DNA fragment in the proximal promotor at -107 to -55 bp after transfection into HeLa cells of a series of 5", 3", and gap deletion mutants linked to a reporter gene, human growth hormone, as well as of synthetic oligonucleotides fused to the heterologous promoter thymidine kinase. Oligonucleotides 369-385 interferon gamma Homo sapiens 4-31 2173701-2 1990 In this study, we analyzed the expression of genes encoding for components of the phagocyte superoxide anion-generating system in human phagocytes treated with interferon-gamma (IFN-gamma) or lipopolysaccharide (LPS). Superoxides 92-108 interferon gamma Homo sapiens 160-176 2173701-2 1990 In this study, we analyzed the expression of genes encoding for components of the phagocyte superoxide anion-generating system in human phagocytes treated with interferon-gamma (IFN-gamma) or lipopolysaccharide (LPS). Superoxides 92-108 interferon gamma Homo sapiens 178-187 2147181-10 1990 Sodium dodecyl sulfate-polyacrylamide gel analysis of the eluted mixture showed the presence of both interferon gamma and interferon gamma receptor at a ratio of 2:1. Sodium Dodecyl Sulfate 0-22 interferon gamma Homo sapiens 101-147 2126575-5 1990 These findings suggest that in vivo IFN-gamma acts directly or indirectly on Leu-11a positive cells and reduces LAK activity by changing the recruitment of LAK precursors in the blood. Leucine 77-80 interferon gamma Homo sapiens 36-45 2147181-10 1990 Sodium dodecyl sulfate-polyacrylamide gel analysis of the eluted mixture showed the presence of both interferon gamma and interferon gamma receptor at a ratio of 2:1. polyacrylamide 23-37 interferon gamma Homo sapiens 101-147 2123793-4 1990 Northern blot analysis of conceptus poly(A)+ RNA with a human IFN-gamma cDNA probe revealed two mRNA of 1.3 and 1.4 kb. Poly A 36-43 interferon gamma Homo sapiens 62-71 2174056-2 1990 The interferon (IFN)-gamma-mediated induction of indoleamine 2,3-dioxygenase (IDO) enzyme, which converts tryptophan into N-formylkynurenine, has been implicated in the inhibition of intracellular pathogens, e.g. Toxoplasma gondii and Chlamydia psittaci, and in the antiproliferative effect of IFN-gamma on tumor cells. Tryptophan 106-116 interferon gamma Homo sapiens 4-26 2174056-2 1990 The interferon (IFN)-gamma-mediated induction of indoleamine 2,3-dioxygenase (IDO) enzyme, which converts tryptophan into N-formylkynurenine, has been implicated in the inhibition of intracellular pathogens, e.g. Toxoplasma gondii and Chlamydia psittaci, and in the antiproliferative effect of IFN-gamma on tumor cells. Tryptophan 106-116 interferon gamma Homo sapiens 294-303 2174056-2 1990 The interferon (IFN)-gamma-mediated induction of indoleamine 2,3-dioxygenase (IDO) enzyme, which converts tryptophan into N-formylkynurenine, has been implicated in the inhibition of intracellular pathogens, e.g. Toxoplasma gondii and Chlamydia psittaci, and in the antiproliferative effect of IFN-gamma on tumor cells. N'-formylkynurenine 122-140 interferon gamma Homo sapiens 4-26 2174056-2 1990 The interferon (IFN)-gamma-mediated induction of indoleamine 2,3-dioxygenase (IDO) enzyme, which converts tryptophan into N-formylkynurenine, has been implicated in the inhibition of intracellular pathogens, e.g. Toxoplasma gondii and Chlamydia psittaci, and in the antiproliferative effect of IFN-gamma on tumor cells. N'-formylkynurenine 122-140 interferon gamma Homo sapiens 294-303 2146363-13 1990 In addition, PHA alone or in combination with PMA induced tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) (but not IL-2) production by CD3- thymocytes. Tetradecanoylphorbol Acetate 46-49 interferon gamma Homo sapiens 102-129 2212676-8 1990 Taken together, these results suggest that IFN-gamma activates PKC and stimulates calcium influx, resulting in the induction of transcription of DRA and B and DPA and B genes without de novo protein synthesis. Calcium 82-89 interferon gamma Homo sapiens 43-52 2212676-8 1990 Taken together, these results suggest that IFN-gamma activates PKC and stimulates calcium influx, resulting in the induction of transcription of DRA and B and DPA and B genes without de novo protein synthesis. dpa 159-162 interferon gamma Homo sapiens 43-52 1700239-4 1990 We show that exposure of SP CML bone marrow promyelocytes/myelocytes to recombinant human (rh) interferon (IFN)-gamma but not to rh IFN-alpha, rh tumor necrosis factor (TNF)-alpha, and rh lymphotoxin (LT) leads to downregulation of G-CSF expression and interruption of the G-CSF-mediated endogenous growth stimulation. TFF2 protein, human 25-27 interferon gamma Homo sapiens 72-117 2120042-4 1990 However, when microsomal membranes are depleted of content by washing with saponin they are still able to co-translationally translocate and glycosylate human IFN-gamma, but the products were of higher apparent Mr than those generated by control microsomes. Saponins 75-82 interferon gamma Homo sapiens 159-168 2120042-5 1990 When saponin-washed microsomal membranes were reconstituted with homogeneous protein disulphide isomerase (PDI), the generated vesicles gave the same pattern of co-translationally glycosylated IFN-gamma as saponin-washed microsomal membranes lacking PDI. Saponins 5-12 interferon gamma Homo sapiens 193-202 2121483-6 1990 In both cell types interferon-gamma selectively inhibited the incorporation of radiolabelled proline into type I collagen. Proline 93-100 interferon gamma Homo sapiens 19-35 2122008-3 1990 The urinary levels of IFN gamma were compared in serial urine samples taken from six patients undergoing treatment with Evans strain BCG and seven patients receiving intravesical mitomycin C/epirubicin. Mitomycin 179-190 interferon gamma Homo sapiens 22-31 2170030-3 1990 Thioglycolate elicited peritoneal macrophages were readily activated to significantly increased levels of intracellular TNF, as early as 1 hr after activation with lypopolysaccharide (LPS) + interferon-gamma: maximum intracellular TNF was evident after 2-3 hr. Thioglycolates 0-13 interferon gamma Homo sapiens 191-207 2119892-5 1990 Interferon-gamma (IFN-gamma) treatment of K562 induced levels of MHC class I antigen surface expression comparable to those found on the transfected cells; however, the IFN-gamma-treated cells were resistant to NK lysis. 5-Bromoisatin 42-46 interferon gamma Homo sapiens 0-16 2119892-5 1990 Interferon-gamma (IFN-gamma) treatment of K562 induced levels of MHC class I antigen surface expression comparable to those found on the transfected cells; however, the IFN-gamma-treated cells were resistant to NK lysis. 5-Bromoisatin 42-46 interferon gamma Homo sapiens 18-27 2119892-5 1990 Interferon-gamma (IFN-gamma) treatment of K562 induced levels of MHC class I antigen surface expression comparable to those found on the transfected cells; however, the IFN-gamma-treated cells were resistant to NK lysis. 5-Bromoisatin 42-46 interferon gamma Homo sapiens 169-178 2120138-7 1990 In other combinations, NMMA in concentrations that abolished secretion of RNI either affected tumor-cell killing only after its induction by IFN gamma, or not at all. omega-N-Methylarginine 23-27 interferon gamma Homo sapiens 141-150 2170520-4 1990 Over a 6-day period of induction the rank order of the ability of these agents to induce expression of PMA-stimulated superoxide production was: IFN-gamma greater than 1,25(OH)2D3 greater than retinoic acid greater than DMSO. Tetradecanoylphorbol Acetate 103-106 interferon gamma Homo sapiens 145-154 2170520-4 1990 Over a 6-day period of induction the rank order of the ability of these agents to induce expression of PMA-stimulated superoxide production was: IFN-gamma greater than 1,25(OH)2D3 greater than retinoic acid greater than DMSO. Superoxides 118-128 interferon gamma Homo sapiens 145-154 2121110-7 1990 We found that no single cytokine, but rather a specific combination of tumor necrosis factor, interleukin-1, interferon-gamma, and endotoxin, were required for maximal induction of HC nitrogen oxide production. Nitrogen Oxides 184-198 interferon gamma Homo sapiens 109-125 2120210-0 1990 Control of tetrahydrobiopterin synthesis in T lymphocytes by synergistic action of interferon-gamma and interleukin-2. sapropterin 11-30 interferon gamma Homo sapiens 83-99 2120210-2 1990 In contrast to the slowly progressing induction of H4biopterin synthesis during activation of resting T cells, it is completed during a 59-h period and is directed by a synergism of interferon-gamma (IFN-gamma) and interleukin-2 (IL-2). sapropterin 51-62 interferon gamma Homo sapiens 182-198 2120210-2 1990 In contrast to the slowly progressing induction of H4biopterin synthesis during activation of resting T cells, it is completed during a 59-h period and is directed by a synergism of interferon-gamma (IFN-gamma) and interleukin-2 (IL-2). sapropterin 51-62 interferon gamma Homo sapiens 200-209 2120210-3 1990 Both GTP cyclohydrolase and (6R)-(1",2"-dioxopropyl)-5,6,7,8-tetrahydropterin synthase activities are induced by IFN-gamma. (6r)-(1",2"-dioxopropyl)-5,6,7 28-58 interferon gamma Homo sapiens 113-122 2120210-6 1990 It is preceded by a fast and transient period of H4biopterin increase which depends on the synergistic action of both IFN-gamma and IL-2. sapropterin 49-60 interferon gamma Homo sapiens 118-127 2120210-9 1990 The accumulation of H4biopterin is suppressed by anti-IFN-gamma polyclonal antibody and correlates with constitutive expression of all H4 biopterin-synthesizing enzymes. sapropterin 20-31 interferon gamma Homo sapiens 54-63 1963300-1 1990 The effect of recombinant human interleukin-2 (rhIL-2) and recombinant human interferon-gamma (rhIFN-gamma) were evaluated on superoxide (O2-) production of human polymorphonuclear neutrophils (PMNs). Superoxides 138-140 interferon gamma Homo sapiens 77-93 1963300-0 1990 Priming effect of recombinant human interleukin-2 and recombinant human interferon-gamma on human neutrophil superoxide production. Superoxides 109-119 interferon gamma Homo sapiens 72-88 2119922-2 1990 Neopterin, a product of IFN-gamma-activated macrophages, was elevated in 94% of patients upon admission (day 0, prior to treatment) and in all at some time during the period of study. Neopterin 0-9 interferon gamma Homo sapiens 24-33 1963300-1 1990 The effect of recombinant human interleukin-2 (rhIL-2) and recombinant human interferon-gamma (rhIFN-gamma) were evaluated on superoxide (O2-) production of human polymorphonuclear neutrophils (PMNs). Superoxides 126-136 interferon gamma Homo sapiens 77-93 1976464-5 1990 The incremental increase in IFN-gamma values from Graves" disease PBMC correlated with the serum TSH values (r = 0.622, P less than 0.01), but not with thyroid autoantibodies (anti-thyroid microsomal antibodies, anti-thyroid microsomal antibodies, nor TSH-binding inhibitory immunoglobulin activities). Thyrotropin 97-100 interferon gamma Homo sapiens 28-37 1976464-5 1990 The incremental increase in IFN-gamma values from Graves" disease PBMC correlated with the serum TSH values (r = 0.622, P less than 0.01), but not with thyroid autoantibodies (anti-thyroid microsomal antibodies, anti-thyroid microsomal antibodies, nor TSH-binding inhibitory immunoglobulin activities). Thyrotropin 252-255 interferon gamma Homo sapiens 28-37 2119922-4 1990 IFN-gamma was measured in 32 patients and found to be directly related to neopterin concentration. Neopterin 74-83 interferon gamma Homo sapiens 0-9 2172158-11 1990 These results indicate that the variation of IL-1-induced production of IL-2 and IFN-gamma in this T-cell line is attributed to the difference in the PHA-mediated signal transduction pathway and, presumably, to the different regulation of intracellular cyclic AMP. Cyclic AMP 253-263 interferon gamma Homo sapiens 81-90 2119790-4 1990 IFN-gamma-induced neutrophil migration was enhanced when the macrophage population of the peritoneal cavities was increased by previous injection of thioglycollate and reduced by peritoneal lavage. Thioglycolates 149-163 interferon gamma Homo sapiens 0-9 2119790-7 1990 These results suggest that IFN-gamma-induced neutrophil migration in vivo may be mediated by the release from resident macrophages of a neutrophil chemotactic factor and that dexamethasone blockade of neutrophil recruitment by IFN-gamma is due to inhibition of the release of this factor. Dexamethasone 175-188 interferon gamma Homo sapiens 27-36 2119790-7 1990 These results suggest that IFN-gamma-induced neutrophil migration in vivo may be mediated by the release from resident macrophages of a neutrophil chemotactic factor and that dexamethasone blockade of neutrophil recruitment by IFN-gamma is due to inhibition of the release of this factor. Dexamethasone 175-188 interferon gamma Homo sapiens 227-236 2120284-5 1990 IFN-gamma was more effective than IFN-beta ser in enhancing serum beta 2 microglobulin expression (P = 0.05) and indoleamine dioxygenase activity, as assessed by decreased serum tryptophan (P = 0.03). Tryptophan 178-188 interferon gamma Homo sapiens 0-9 2120284-8 1990 IFN-beta ser/IFN-gamma enhanced monocyte guanylate cyclase activity, as assessed by serum neopterin, more effectively than IFN-gamma alone (P = 0.005). Neopterin 90-99 interferon gamma Homo sapiens 13-22 2120285-5 1990 Furthermore, IFN gamma overcame the inhibition of cachectin/TNF synthesis caused by the glucocorticoid, dexamethasone. Dexamethasone 104-117 interferon gamma Homo sapiens 13-22 2125633-4 1990 Recently, we have shown that human recombinant IFN-gamma is a potent inhibitor of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-induced formation of multinucleated cells (MNC) that express the osteoclast phenotype. Calcitriol 82-106 interferon gamma Homo sapiens 47-56 1703196-0 1990 Enhancement of interferon-gamma-induced differentiation of human monoblastic leukemia U-937 cells by cAMP-inducing agents. Cyclic AMP 101-105 interferon gamma Homo sapiens 15-31 1703196-2 1990 IFN-gamma induced nitro blue tetrazolium (NBT) reducing activity of U-937 cells in a dose-dependent manner, while cAMP-inducing agents such as cholera toxin, prostaglandin E1, forskolin, and isoproterenol only marginally induced NBT reducing activity. Nitroblue Tetrazolium 18-40 interferon gamma Homo sapiens 0-9 1703196-2 1990 IFN-gamma induced nitro blue tetrazolium (NBT) reducing activity of U-937 cells in a dose-dependent manner, while cAMP-inducing agents such as cholera toxin, prostaglandin E1, forskolin, and isoproterenol only marginally induced NBT reducing activity. Nitroblue Tetrazolium 42-45 interferon gamma Homo sapiens 0-9 1703196-2 1990 IFN-gamma induced nitro blue tetrazolium (NBT) reducing activity of U-937 cells in a dose-dependent manner, while cAMP-inducing agents such as cholera toxin, prostaglandin E1, forskolin, and isoproterenol only marginally induced NBT reducing activity. Cyclic AMP 114-118 interferon gamma Homo sapiens 0-9 1703196-2 1990 IFN-gamma induced nitro blue tetrazolium (NBT) reducing activity of U-937 cells in a dose-dependent manner, while cAMP-inducing agents such as cholera toxin, prostaglandin E1, forskolin, and isoproterenol only marginally induced NBT reducing activity. Isoproterenol 191-204 interferon gamma Homo sapiens 0-9 1703196-2 1990 IFN-gamma induced nitro blue tetrazolium (NBT) reducing activity of U-937 cells in a dose-dependent manner, while cAMP-inducing agents such as cholera toxin, prostaglandin E1, forskolin, and isoproterenol only marginally induced NBT reducing activity. Nitroblue Tetrazolium 229-232 interferon gamma Homo sapiens 0-9 1703196-3 1990 However, they all synergistically increased IFN-gamma induction of NBT reducing activity. Nitroblue Tetrazolium 67-70 interferon gamma Homo sapiens 44-53 2118972-0 1990 Increased mitochondrial uptake of rhodamine 123 during interferon-gamma stimulation in Molt 16 cells. Rhodamine 123 34-47 interferon gamma Homo sapiens 55-71 2118972-4 1990 In the present work, the uptake of rhodamine 123 by Molt 16 cells stimulated by IFN-gamma or IFN-beta was measured by flow cytometry. Rhodamines 35-44 interferon gamma Homo sapiens 80-89 2125633-4 1990 Recently, we have shown that human recombinant IFN-gamma is a potent inhibitor of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-induced formation of multinucleated cells (MNC) that express the osteoclast phenotype. Calcitriol 108-119 interferon gamma Homo sapiens 47-56 1697502-4 1990 Simultaneous treatment of H630 with subinhibitory concentrations of IFN-gamma and 5-FU produced a significant enhancement of the 5-FU-associated growth inhibition. Fluorouracil 129-133 interferon gamma Homo sapiens 68-77 2121524-2 1990 Its catalytic activity against double-stranded RNA, either homopolymeric ([3H]polyA/polyU) or mixed sequence, is enhanced by bovine or human recombinant interferon-gamma (IFN-gamma). Tritium 75-77 interferon gamma Homo sapiens 153-169 2121524-2 1990 Its catalytic activity against double-stranded RNA, either homopolymeric ([3H]polyA/polyU) or mixed sequence, is enhanced by bovine or human recombinant interferon-gamma (IFN-gamma). Tritium 75-77 interferon gamma Homo sapiens 171-180 1697499-4 1990 IFN gamma also enhanced the cytotoxic effects of FUra, but unlike IFN alpha and -beta, only at the highest concentrations tested. Fluorouracil 49-53 interferon gamma Homo sapiens 0-9 2119787-0 1990 Differential enhancement of interferon-gamma-induced MHC class II expression of HEp-2 cells by 1,25-dihydroxyvitamin D3. Calcitriol 95-119 interferon gamma Homo sapiens 28-44 2119787-2 1990 In this study we investigated the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the most active metabolite of vitamin D3, on the IFN-gamma-induced expression of MHC class II antigens on HEp-2 cells. Calcitriol 44-70 interferon gamma Homo sapiens 133-142 2119787-2 1990 In this study we investigated the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the most active metabolite of vitamin D3, on the IFN-gamma-induced expression of MHC class II antigens on HEp-2 cells. Calcitriol 70-81 interferon gamma Homo sapiens 133-142 2119787-2 1990 In this study we investigated the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the most active metabolite of vitamin D3, on the IFN-gamma-induced expression of MHC class II antigens on HEp-2 cells. Cholecalciferol 58-68 interferon gamma Homo sapiens 133-142 1697502-7 1990 A 24-h exposure to 1 microM 5-FU in the H630 line resulted in a 3.1-fold increase in the total amount of TS, while in the 5-FU/IFN-gamma-treated cells TS remained unchanged from non-drug-treated control levels. Fluorouracil 28-32 interferon gamma Homo sapiens 127-136 1697502-7 1990 A 24-h exposure to 1 microM 5-FU in the H630 line resulted in a 3.1-fold increase in the total amount of TS, while in the 5-FU/IFN-gamma-treated cells TS remained unchanged from non-drug-treated control levels. Fluorouracil 122-126 interferon gamma Homo sapiens 127-136 1697502-8 1990 Moreover, we found that free thymidylate synthase in the 5-FU/IFN-gamma-treated cells was significantly decreased, as compared to the cells treated with 5-FU alone. Fluorouracil 57-61 interferon gamma Homo sapiens 62-71 2143437-4 1990 Comparison of the mechanisms regulating the in vitro IgE synthesis by adult and neonatal lymphocytes indicates that in most cases IFN-gamma markedly potentiates the IgE synthesis in CBMC cultures whereas it has a reverse effect on adult lymphocytes. cbmc 182-186 interferon gamma Homo sapiens 130-139 1697502-8 1990 Moreover, we found that free thymidylate synthase in the 5-FU/IFN-gamma-treated cells was significantly decreased, as compared to the cells treated with 5-FU alone. Fluorouracil 153-157 interferon gamma Homo sapiens 62-71 1697502-12 1990 These studies contribute to a growing understanding of the complex interaction between 5-FU and IFN-gamma. Fluorouracil 87-91 interferon gamma Homo sapiens 96-105 1963781-0 1990 Characterization of a polyethylene glycol conjugate of recombinant human interferon-gamma. Polyethylene Glycols 22-41 interferon gamma Homo sapiens 73-89 2166625-6 1990 Phagocytosis of particulate immune complexes (EAs) as well as production of superoxide (O2-) in response to EAs were inhibited by IL-4, and the inhibition was reversed by IFN. CHEMBL4167713 46-49 interferon gamma Homo sapiens 171-174 2166625-6 1990 Phagocytosis of particulate immune complexes (EAs) as well as production of superoxide (O2-) in response to EAs were inhibited by IL-4, and the inhibition was reversed by IFN. Superoxides 76-86 interferon gamma Homo sapiens 171-174 2166625-6 1990 Phagocytosis of particulate immune complexes (EAs) as well as production of superoxide (O2-) in response to EAs were inhibited by IL-4, and the inhibition was reversed by IFN. Superoxides 88-90 interferon gamma Homo sapiens 171-174 2166625-6 1990 Phagocytosis of particulate immune complexes (EAs) as well as production of superoxide (O2-) in response to EAs were inhibited by IL-4, and the inhibition was reversed by IFN. CHEMBL4167713 108-111 interferon gamma Homo sapiens 171-174 1963781-1 1990 Recombinant human interferon-gamma was conjugated with polyethylene glycol (PEG) using succinimidyl coupling of amino groups in the protein. Polyethylene Glycols 55-74 interferon gamma Homo sapiens 18-34 1963781-1 1990 Recombinant human interferon-gamma was conjugated with polyethylene glycol (PEG) using succinimidyl coupling of amino groups in the protein. Polyethylene Glycols 76-79 interferon gamma Homo sapiens 18-34 1963781-1 1990 Recombinant human interferon-gamma was conjugated with polyethylene glycol (PEG) using succinimidyl coupling of amino groups in the protein. succinimidyl 87-99 interferon gamma Homo sapiens 18-34 1974653-7 1990 By in situ hybridization with a [35S]dATP-labeled IFN-gamma cDNA probe, only the AGM1-bearing cells were found to contain detectable IFN-gamma gene transcripts. Sulfur-35 33-36 interferon gamma Homo sapiens 50-59 1701160-3 1990 Northern blot analysis revealed that these reagents regulate the Fc epsilon R2/CD23 expression from mRNA level: both IFN-alpha and IFN-gamma increased the amount of Fc epsilon R2/CD23 mRNA, while both dexamethasone and TGF-beta decreased Fc epsilon R2/CD23 mRNA, where the effect of dexamethasone was much stronger than that of TGF-beta. Dexamethasone 201-214 interferon gamma Homo sapiens 131-140 1701160-3 1990 Northern blot analysis revealed that these reagents regulate the Fc epsilon R2/CD23 expression from mRNA level: both IFN-alpha and IFN-gamma increased the amount of Fc epsilon R2/CD23 mRNA, while both dexamethasone and TGF-beta decreased Fc epsilon R2/CD23 mRNA, where the effect of dexamethasone was much stronger than that of TGF-beta. Dexamethasone 283-296 interferon gamma Homo sapiens 131-140 1974653-7 1990 By in situ hybridization with a [35S]dATP-labeled IFN-gamma cDNA probe, only the AGM1-bearing cells were found to contain detectable IFN-gamma gene transcripts. 2'-deoxyadenosine triphosphate 37-41 interferon gamma Homo sapiens 50-59 2142945-7 1990 The observed heterogeneity of the soluble interferon gamma receptor under nonreducing electrophoretic conditions is probably due to different conformational forms resulting from the formation of non-native intramolecular disulfide bonds among the 8 cysteine residues present in the soluble interferon gamma receptor molecule. Disulfides 221-230 interferon gamma Homo sapiens 42-58 2116480-5 1990 Approximately 6 U/ml of IFN-gamma was detected by an ELISA assay in the 12-h culture supernatant with 2 x 10(6) leukocytes/ml, and rIFN-gamma at 6 U/ml induced IDO in 3-methylcholanthrene-induced ascites type tumor cells to the same extent as IFN-gamma in the culture supernatant. Methylcholanthrene 167-187 interferon gamma Homo sapiens 24-33 2116480-5 1990 Approximately 6 U/ml of IFN-gamma was detected by an ELISA assay in the 12-h culture supernatant with 2 x 10(6) leukocytes/ml, and rIFN-gamma at 6 U/ml induced IDO in 3-methylcholanthrene-induced ascites type tumor cells to the same extent as IFN-gamma in the culture supernatant. Methylcholanthrene 167-187 interferon gamma Homo sapiens 132-141 2142945-7 1990 The observed heterogeneity of the soluble interferon gamma receptor under nonreducing electrophoretic conditions is probably due to different conformational forms resulting from the formation of non-native intramolecular disulfide bonds among the 8 cysteine residues present in the soluble interferon gamma receptor molecule. Cysteine 249-257 interferon gamma Homo sapiens 42-58 2395002-8 1990 IFN-gamma enhanced the expression of p78 induction by IFN-alpha or IFN-beta ser, even at concentrations of IFN-gamma that did not induce the protein when administered as a single agent. Serine 76-79 interferon gamma Homo sapiens 0-9 2117917-5 1990 The increased PGE production provoked by tumour necrosis factor alpha (TNF alpha) in RSC was also augmented by staurosporine, but, in contrast, the increases in cellular [Fru(2,6)P2] induced by transforming growth factor beta (TGF beta) and interferon-gamma (IFN-gamma) were diminished. Prostaglandins E 14-17 interferon gamma Homo sapiens 241-257 2117917-5 1990 The increased PGE production provoked by tumour necrosis factor alpha (TNF alpha) in RSC was also augmented by staurosporine, but, in contrast, the increases in cellular [Fru(2,6)P2] induced by transforming growth factor beta (TGF beta) and interferon-gamma (IFN-gamma) were diminished. Prostaglandins E 14-17 interferon gamma Homo sapiens 259-268 2117917-7 1990 These findings suggest that IL-1 alpha and probably TNF alpha act via an intracellular mechanism different from that mediating the action of TPA, TGF-beta and IFN-gamma, and provide evidence that staurosporine is capable of amplifying the IL-1 signal. Staurosporine 196-209 interferon gamma Homo sapiens 159-168 2119792-4 1990 In addition, tumour necrosis factor (TNF) and interferon-gamma (IFN-gamma), two cytokines released from mononuclear cells in response to IL2, also reduced the survival and thymidine uptake of malignant plasma cells in culture. Thymidine 172-181 interferon gamma Homo sapiens 46-62 2119792-4 1990 In addition, tumour necrosis factor (TNF) and interferon-gamma (IFN-gamma), two cytokines released from mononuclear cells in response to IL2, also reduced the survival and thymidine uptake of malignant plasma cells in culture. Thymidine 172-181 interferon gamma Homo sapiens 64-73 1974207-8 1990 Isotype-specific H2O2 release was abrogated with the enzymatic removal of the Fc portion of the Ig and enhanced by interferon-gamma pretreatment, indicating that the membrane signal was mediated by cell surface Fc receptors. Hydrogen Peroxide 17-21 interferon gamma Homo sapiens 115-131 1700029-7 1990 IFN-gamma treatment also inhibited the enhancement in gamma-globin synthesis induced in culture by butyric acid. Butyric Acid 99-111 interferon gamma Homo sapiens 0-9 2143376-3 1990 Unlike what is observed in neutrophils, induction by IFN-gamma of macrophage Fc gamma R-I mRNA was significantly depressed by the Na+/H+ antiporter inhibitor amiloride. Amiloride 158-167 interferon gamma Homo sapiens 53-62 2114374-9 1990 The addition of TNF/IFN-gamma to clinically achievable concentrations of 5-FU in both schedules resulted in additive cytotoxicity. Fluorouracil 73-77 interferon gamma Homo sapiens 16-29 2114374-10 1990 For example, the addition of 10 ng/ml of both TNF and IFN-gamma to 96 hr of 0.1 microgram/ml 5-FU resulted in 10%, 5%, and 20% of control growth for the HCT 116 cell line, SKCO1 cell line, and VACO 9P cell line, respectively. Fluorouracil 93-97 interferon gamma Homo sapiens 54-63 2114374-11 1990 The addition of 10 ng/ml of both TNF and IFN-gamma to 1 hr of 50 micrograms/ml of 5-FU inhibited all cell growth in all 3 cell lines. Fluorouracil 82-86 interferon gamma Homo sapiens 41-50 2166488-1 1990 The effects of recombinant interferon gamma (rIFN gamma) on the in vitro growth of adherent synovial fibroblast-like cells from patients with rheumatoid arthritis (RA) and also on the release of prostaglandin E2 and collagenase from these cells stimulated with recombinant interleukin-1 beta (rIL-1 beta) were investigated. Dinoprostone 195-211 interferon gamma Homo sapiens 27-55 2135377-5 1990 Phenytoin appeared to exert its inhibitory effect directly on the IFN-gamma-producing cell and was active even when added as late as 6 h after IFN-gamma induction. Phenytoin 0-9 interferon gamma Homo sapiens 66-75 2115042-6 1990 Assay of insulin and glucagon in the islet monolayers revealed that IL-1, TNF, and IFN gamma inhibited both B- and A-cell secretory functions; however, only IL-1 and TNF produced permanent decreases in insulin and glucagon contents in the islet cultures. Glucagon 21-29 interferon gamma Homo sapiens 83-92 2115042-6 1990 Assay of insulin and glucagon in the islet monolayers revealed that IL-1, TNF, and IFN gamma inhibited both B- and A-cell secretory functions; however, only IL-1 and TNF produced permanent decreases in insulin and glucagon contents in the islet cultures. Glucagon 214-222 interferon gamma Homo sapiens 83-92 2151306-6 1990 It has been reported that the epidermal beta-adrenergic adenylate cyclase response is decreased following the TPA- (and OAG-) induced activation of protein kinase C. Human recombinant IFN-gamma, however, had no effect on the beta-adrenergic response of the human epidermis. Tetradecanoylphorbol Acetate 110-113 interferon gamma Homo sapiens 184-193 2135377-5 1990 Phenytoin appeared to exert its inhibitory effect directly on the IFN-gamma-producing cell and was active even when added as late as 6 h after IFN-gamma induction. Phenytoin 0-9 interferon gamma Homo sapiens 143-152 1971531-5 1990 Cyclosporine (CsA) prevented diC8 and ionomycin-induced expression of IL-2, IFN-gamma, and H-ras genes. Cyclosporine 0-12 interferon gamma Homo sapiens 76-85 1971531-5 1990 Cyclosporine (CsA) prevented diC8 and ionomycin-induced expression of IL-2, IFN-gamma, and H-ras genes. 1,2-dioctanoylglycerol 29-33 interferon gamma Homo sapiens 76-85 1971531-5 1990 Cyclosporine (CsA) prevented diC8 and ionomycin-induced expression of IL-2, IFN-gamma, and H-ras genes. Ionomycin 38-47 interferon gamma Homo sapiens 76-85 2110909-3 1990 When anti-interferon (IFN)-gamma antibody or anti-tumor necrosis factor (TNF)-alpha antibody was added to CFU-GM agar culture with IL-2-treated lymphocytes or their CM, the inhibition of CFU-GM colony formation was partially abrogated, whereas anti-TNF-beta antibody did not abolish the inhibitory effects. Agar 113-117 interferon gamma Homo sapiens 5-32 2141042-0 1990 Differential regulation of the human IFN-gamma receptor expression in Raji and IM9 lymphoblastoid cells versus THP-1 monocytic cells by IFN-gamma and phorbol myristate acetate. Tetradecanoylphorbol Acetate 150-175 interferon gamma Homo sapiens 37-46 2110909-6 1990 Addition of IFN-gamma and TNF-alpha at these concentrations to the agar culture inhibited CFU-GM colony formation. Agar 67-71 interferon gamma Homo sapiens 12-21 2112152-8 1990 Although the main mechanism of 131I uptake suppression in the thyroid gland in subacute thyroiditis is due to cellular damage and suppression of TSH release, our present findings suggest that IL-1, TNF alpha, and IFN gamma produced in the inflammatory process within the thyroid gland further inhibit iodine incorporation and at least partly account for the decreased 131I uptake by the thyroid gland in destruction-induced hyperthyroidism. Iodine-131 31-35 interferon gamma Homo sapiens 213-222 2140394-0 1990 Role of intracellular calcium concentration and protein kinase C activation in IFN-gamma stimulation of U937 cells. Calcium 22-29 interferon gamma Homo sapiens 79-88 2161422-6 1990 At 500 U/mL, IFN gamma inhibited TSH- or dibutyryl cAMP-induced TG synthesis at the gene transcription level, as evidenced by the decrease in steady state TG mRNA. dibutyryl 41-50 interferon gamma Homo sapiens 13-22 2161422-6 1990 At 500 U/mL, IFN gamma inhibited TSH- or dibutyryl cAMP-induced TG synthesis at the gene transcription level, as evidenced by the decrease in steady state TG mRNA. Cyclic AMP 51-55 interferon gamma Homo sapiens 13-22 2140394-5 1990 IFN-gamma caused a rapid and concentration-dependent increase in [Ca2+]i, which was partly inhibited by calcium-free medium, diltiazem, and TMB-8. Calcium 104-111 interferon gamma Homo sapiens 0-9 2140394-5 1990 IFN-gamma caused a rapid and concentration-dependent increase in [Ca2+]i, which was partly inhibited by calcium-free medium, diltiazem, and TMB-8. Diltiazem 125-134 interferon gamma Homo sapiens 0-9 2140394-5 1990 IFN-gamma caused a rapid and concentration-dependent increase in [Ca2+]i, which was partly inhibited by calcium-free medium, diltiazem, and TMB-8. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 140-145 interferon gamma Homo sapiens 0-9 2140394-6 1990 IFN-gamma induced a fourfold increase in the concentration of inositol 1,4,5-trisphosphate. Inositol 1,4,5-Trisphosphate 62-90 interferon gamma Homo sapiens 0-9 2140394-7 1990 Induction of HLA-DR, Fc gamma R, CR3, and Mo3e Ag expression by IFN-gamma was blocked by concentrations of TMB-8 that inhibited an increase in [Ca2+]i, but not by protein kinase C inhibition by H-7 or inhibition of calmodulin with W-7. 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 107-112 interferon gamma Homo sapiens 64-73 2140394-9 1990 We conclude that IFN-gamma induces antigenic expression on human U937 cells by a mechanism dependent on, but not limited to, an increase in intracellular calcium, which is likely due to inositol 1,4,5-trisphosphate generation. Calcium 154-161 interferon gamma Homo sapiens 17-26 2140394-9 1990 We conclude that IFN-gamma induces antigenic expression on human U937 cells by a mechanism dependent on, but not limited to, an increase in intracellular calcium, which is likely due to inositol 1,4,5-trisphosphate generation. Inositol 1,4,5-Trisphosphate 186-214 interferon gamma Homo sapiens 17-26 2163132-10 1990 Our results indicate that enhanced endogenous production of TNF-alpha and IFN-gamma accompanied by elevated levels of B2M and neopterin represent a regular feature of inflammatory complications after liver transplantation. Neopterin 126-135 interferon gamma Homo sapiens 74-83 2163140-0 1990 Modulation of human peripheral blood monocyte superoxide release by interferon-gamma and lipopolysaccharide. Superoxides 46-56 interferon gamma Homo sapiens 68-84 2163140-2 1990 Interferon-gamma (IFN-gamma), a potent immunoregulatory lymphokine, is likely involved in control of ROS metabolism. Reactive Oxygen Species 101-104 interferon gamma Homo sapiens 0-16 2163140-2 1990 Interferon-gamma (IFN-gamma), a potent immunoregulatory lymphokine, is likely involved in control of ROS metabolism. Reactive Oxygen Species 101-104 interferon gamma Homo sapiens 18-27 2163140-3 1990 In this study, the superoxide release of cultured human peripheral blood monocytes (PBM) after exposure to IFN-gamma and lipopolysaccharide (LPS) was examined. Superoxides 19-29 interferon gamma Homo sapiens 107-116 2163140-4 1990 Compared with controls, adherent monocytes cultured with 80 units of IFN-gamma for 48 hours demonstrated fourfold increased spontaneous and twofold increased PMA stimulated release of superoxide anion. Superoxides 184-200 interferon gamma Homo sapiens 69-78 1692061-4 1990 The PKC inhibitors H-7 and phloretin were found to block Ly-6E induction by IFN-gamma or IFN-alpha/beta both at the mRNA and protein levels. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 19-22 interferon gamma Homo sapiens 76-85 1692061-4 1990 The PKC inhibitors H-7 and phloretin were found to block Ly-6E induction by IFN-gamma or IFN-alpha/beta both at the mRNA and protein levels. Phloretin 27-36 interferon gamma Homo sapiens 76-85 2110799-5 1990 IFN-gamma did not significantly alter the total cell content of globoside, as measured by metabolic labeling, but rather altered the ratio of accessible cell surface to intracellular globoside. Globosides 183-192 interferon gamma Homo sapiens 0-9 2110799-0 1990 Interferon-gamma alters expression of endothelial cell-surface glycosphingolipids. Glycosphingolipids 63-81 interferon gamma Homo sapiens 0-16 2110799-10 1990 The specific modulation of cell-surface GSLs by IFN-gamma suggests that GSLs may play a role in the altered adhesive and receptor activities of IFN-gamma-activated ECs. Glycosphingolipids 40-44 interferon gamma Homo sapiens 48-57 2110799-3 1990 IFN-gamma activation of endothelial cells resulted in a small change in GSL composition, but greatly increased surface expression of gangliosides and decreased surface expression of neutral GSLs. Gangliosides 133-145 interferon gamma Homo sapiens 0-9 2110799-3 1990 IFN-gamma activation of endothelial cells resulted in a small change in GSL composition, but greatly increased surface expression of gangliosides and decreased surface expression of neutral GSLs. Glycosphingolipids 190-194 interferon gamma Homo sapiens 0-9 2110799-10 1990 The specific modulation of cell-surface GSLs by IFN-gamma suggests that GSLs may play a role in the altered adhesive and receptor activities of IFN-gamma-activated ECs. Glycosphingolipids 40-44 interferon gamma Homo sapiens 144-153 2110799-10 1990 The specific modulation of cell-surface GSLs by IFN-gamma suggests that GSLs may play a role in the altered adhesive and receptor activities of IFN-gamma-activated ECs. Glycosphingolipids 72-76 interferon gamma Homo sapiens 48-57 2110799-10 1990 The specific modulation of cell-surface GSLs by IFN-gamma suggests that GSLs may play a role in the altered adhesive and receptor activities of IFN-gamma-activated ECs. Glycosphingolipids 72-76 interferon gamma Homo sapiens 144-153 2109093-0 1990 Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. Nitrogen Oxides 31-46 interferon gamma Homo sapiens 62-78 2114820-4 1990 Three of the four cytokine preparations (Il-4, TNF and IFN-alpha/beta), however, increased the macrophages capacity to secrete H2O2 in response to either immune complex or PMA, IFN-gamma alone did not affect H2O2 secretion. Hydrogen Peroxide 127-131 interferon gamma Homo sapiens 177-186 2109093-4 1990 In this study, we tested interferon gamma, tumor necrosis factor, interleukin-1, interleukin-2, muramyl dipeptide, and endotoxin for their effects on production of nitrogen oxides by endothelial cells. Nitrogen Oxides 164-179 interferon gamma Homo sapiens 25-64 2115008-5 1990 For erythropoiesis, IL-3 was much more effective and partially reversed IFN gamma-mediated inhibition by increasing burst forming units-erythroid (BFU-E) in a proportion ranging from 52-138%. erythroid 136-145 interferon gamma Homo sapiens 72-81 2110190-9 1990 Moreover, 1,25(OH)2D3 enhanced IFN gamma-induced DR expression and at high concentration (10(-7) M) augmented DR expression by itself. Calcitriol 10-21 interferon gamma Homo sapiens 31-40 2113442-2 1990 Pre-incubation of either monocytes or macrophages with rTNF-alpha or IFN-gamma (100 U/5 x 10(5) cells) augmented their respiratory burst to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), measured by the luminol- and lucigenin-dependent chemiluminescence assay. formyl-l-methionyl-l-leucyl-l-phenylalanine 140-183 interferon gamma Homo sapiens 69-78 2113442-2 1990 Pre-incubation of either monocytes or macrophages with rTNF-alpha or IFN-gamma (100 U/5 x 10(5) cells) augmented their respiratory burst to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), measured by the luminol- and lucigenin-dependent chemiluminescence assay. Luminol 208-215 interferon gamma Homo sapiens 69-78 2113442-2 1990 Pre-incubation of either monocytes or macrophages with rTNF-alpha or IFN-gamma (100 U/5 x 10(5) cells) augmented their respiratory burst to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), measured by the luminol- and lucigenin-dependent chemiluminescence assay. 10,10'-dimethyl-9,9'-biacridinium 221-230 interferon gamma Homo sapiens 69-78 2166023-2 1990 IFN-gamma (100 units/ml) or cholera toxin (10(-9) M) alone only marginally induced various differentiation-associated characteristics such as NBT-reducing activity, phagocytic activity, a-naphthyl acetate esterase activity and surface markers. Nitroblue Tetrazolium 142-145 interferon gamma Homo sapiens 0-9 2158512-0 1990 Inhibition of phospholipase activity in human monocytes by IFN-gamma blocks endogenous prostaglandin E2-dependent collagenase production. Dinoprostone 87-103 interferon gamma Homo sapiens 59-68 2163552-9 1990 The binding could not be up-regulated with either phorbol myristyl acetate, interferon gamma or ADP, but was abolished by EDTA and by lipopolysaccharide. Edetic Acid 122-126 interferon gamma Homo sapiens 76-92 1695452-2 1990 Cells from approximately half of the AIDS patients, in contrast to none from the control group, showed histamine release after stimulation with interleukin-4 (IL-4), tumor necrosis factor alpha (TNF alpha), lymphotoxin (LT) and interferon gamma (IFN gamma). Histamine 103-112 interferon gamma Homo sapiens 228-244 1695452-2 1990 Cells from approximately half of the AIDS patients, in contrast to none from the control group, showed histamine release after stimulation with interleukin-4 (IL-4), tumor necrosis factor alpha (TNF alpha), lymphotoxin (LT) and interferon gamma (IFN gamma). Histamine 103-112 interferon gamma Homo sapiens 246-255 2126259-0 1990 The influence of beta-estradiol and progesterone on interferon gamma production in vitro. Estradiol 17-31 interferon gamma Homo sapiens 52-68 2109379-10 1990 Patients who received high-dose corticosteroids (1 g solumedrol bolus) concomitantly with the first OKT3 injection still had high TNF and IFN gamma levels. Methylprednisolone Hemisuccinate 53-63 interferon gamma Homo sapiens 138-147 2148048-2 1990 This paper describes a simple dot blot assay with 32P-labeled human interferon gamma (Hu-IFN-gamma) for the detection of a functionally active Hu-IFN-gamma receptor from soluble plasma membranes prepared from human placenta. Phosphorus-32 50-53 interferon gamma Homo sapiens 68-98 1690989-3 1990 Furthermore, 4 h-treatment with TPA or lipopolysaccharide (LPS) induced a marked increase in beta A chain mRNA levels in interferon-gamma-pretreated HL-60 cells. Tetradecanoylphorbol Acetate 32-35 interferon gamma Homo sapiens 121-137 1690989-6 1990 These results indicate that interferon-gamma has a priming effect on the activation of activin A/erythroid differentiation factor gene by TPA or LPS in HL-60 cells. Tetradecanoylphorbol Acetate 138-141 interferon gamma Homo sapiens 28-44 2107096-0 1990 Organoselenides as potential immunostimulants and inducers of interferon gamma and other cytokines in human peripheral blood leukocytes. organoselenides 0-15 interferon gamma Homo sapiens 62-78 2112196-0 1990 Inhibitory effects of gold sodium thiomalate on the proliferation and interferon-gamma induced HLA-DR expression in human endothelial cells. Gold Sodium Thiomalate 22-44 interferon gamma Homo sapiens 70-86 2107096-2 1990 Here we report that bis [2-(N-phenyl-carboxamido)]phenyl diselenide, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen) and related compounds are inducers of interferon gamma (IFN-gamma) and tumor necrosis factor (TNF) in human peripheral blood leukocytes. bis(2-(N-phenylcarboxamido)phenyl)diselenide 20-67 interferon gamma Homo sapiens 157-184 2107991-5 1990 Reduced IFN-gamma secretion was observed after stimulation with the CD3 monoclonal antibody OKT3, ionomycin + 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or with high levels of IL-2 (200 U/ml). Ionomycin 98-107 interferon gamma Homo sapiens 8-17 2107096-2 1990 Here we report that bis [2-(N-phenyl-carboxamido)]phenyl diselenide, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen) and related compounds are inducers of interferon gamma (IFN-gamma) and tumor necrosis factor (TNF) in human peripheral blood leukocytes. ebselen 69-108 interferon gamma Homo sapiens 157-184 2107096-2 1990 Here we report that bis [2-(N-phenyl-carboxamido)]phenyl diselenide, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen) and related compounds are inducers of interferon gamma (IFN-gamma) and tumor necrosis factor (TNF) in human peripheral blood leukocytes. ebselen 110-117 interferon gamma Homo sapiens 157-184 2105896-6 1990 Inhibition of RNA or protein synthesis by actinomycin D or cycloheximide did not prevent the antiproliferative action of IFN gamma nor the induction of monocytic differentiation, yet these two compounds blocked the priming effect of IFN gamma on the potentiation of 5-FU action. Fluorouracil 266-270 interferon gamma Homo sapiens 233-242 2105896-7 1990 Actinomycin D synergistically potentiated the antiproliferative action of IFN gamma. Dactinomycin 0-13 interferon gamma Homo sapiens 74-83 2109703-4 1990 Neopterin levels correlated significantly to interferon-gamma concentrations and inversely to haemoglobin levels. Neopterin 0-9 interferon gamma Homo sapiens 45-61 2107991-5 1990 Reduced IFN-gamma secretion was observed after stimulation with the CD3 monoclonal antibody OKT3, ionomycin + 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or with high levels of IL-2 (200 U/ml). Tetradecanoylphorbol Acetate 110-147 interferon gamma Homo sapiens 8-17 2107991-5 1990 Reduced IFN-gamma secretion was observed after stimulation with the CD3 monoclonal antibody OKT3, ionomycin + 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or with high levels of IL-2 (200 U/ml). Tetradecanoylphorbol Acetate 149-152 interferon gamma Homo sapiens 8-17 2113148-1 1990 Synergistic effect of recombinant IFN-gamma (IFN-gamma) and OK-432, a streptococcal preparation, using chromium release assay was studied in vitro on killer cell induction. Chromium 103-111 interferon gamma Homo sapiens 34-43 2106525-3 1990 The data presented here suggest that IFN gamma and calcium ionophore A23187 promote enhanced expression of the sarcoid PAM 25OHD3-1-hydroxylation reaction by increasing endogenous arachidonic acid metabolism through the 5-lipoxygenase pathway. Arachidonic Acid 180-196 interferon gamma Homo sapiens 37-46 2106525-6 1990 The results of this study provide presumptive evidence for an important role of agonist (IFN gamma)-calcium-modulated eicosanoid metabolism in the regulated synthesis of 1,25-(OH)2D by PAM in sarcoidosis. Calcium 100-107 interferon gamma Homo sapiens 89-98 2106525-6 1990 The results of this study provide presumptive evidence for an important role of agonist (IFN gamma)-calcium-modulated eicosanoid metabolism in the regulated synthesis of 1,25-(OH)2D by PAM in sarcoidosis. Eicosanoids 118-128 interferon gamma Homo sapiens 89-98 2154472-2 1990 Interferon-gamma induces tetrahydrobiopterin biosynthesis in human cells and cell lines. sapropterin 25-44 interferon gamma Homo sapiens 0-16 2107102-0 1990 De novo protein synthesis is essential to human interferon gamma gene expression by the stimulation with polyI:polyC. Poly I 105-110 interferon gamma Homo sapiens 48-64 2107102-1 1990 Transcription of human interferon (IFN) gamma gene is induced in human peripheral lymphocyte nylon-nonadherent cells (NNA cells) by double strand RNA poly I:poly C [(1985) J. Interferon Res. Poly C 157-163 interferon gamma Homo sapiens 23-45 2107102-4 1990 For induction of IFN gamma gene expression, only initial 4 h treatment of poly I:poly C to NNA cells is sufficient. Poly C 81-87 interferon gamma Homo sapiens 17-26 2105994-8 1990 Although IFN-gamma, IL-6, granulocyte CSF, and granulocyte-macrophage CSF-induced nitroblue tetrazolium reducing activity of U-937 cells, only IFN-gamma, and TNF induced it synergistically in combination with TGF-beta 1. Nitroblue Tetrazolium 82-103 interferon gamma Homo sapiens 9-18 2107102-5 1990 Addition of inhibitor of protein synthesis, cycloheximide (CHX), at an early stage of induction periods (0-4 h) inhibits the IFN gamma induction by poly I:poly C. Cycloheximide 44-57 interferon gamma Homo sapiens 125-134 2107102-5 1990 Addition of inhibitor of protein synthesis, cycloheximide (CHX), at an early stage of induction periods (0-4 h) inhibits the IFN gamma induction by poly I:poly C. Cycloheximide 59-62 interferon gamma Homo sapiens 125-134 2107102-5 1990 Addition of inhibitor of protein synthesis, cycloheximide (CHX), at an early stage of induction periods (0-4 h) inhibits the IFN gamma induction by poly I:poly C. Poly I 148-154 interferon gamma Homo sapiens 125-134 2107102-5 1990 Addition of inhibitor of protein synthesis, cycloheximide (CHX), at an early stage of induction periods (0-4 h) inhibits the IFN gamma induction by poly I:poly C. Poly C 155-161 interferon gamma Homo sapiens 125-134 2107102-6 1990 Cell free translation assay using RNAs isolated from NNA cells which are induced by poly I:poly C in the presence of CHX reveals that in these RNAs, IFN gamma mRNA does not exist. Poly I 84-90 interferon gamma Homo sapiens 149-158 2107102-6 1990 Cell free translation assay using RNAs isolated from NNA cells which are induced by poly I:poly C in the presence of CHX reveals that in these RNAs, IFN gamma mRNA does not exist. Poly C 91-97 interferon gamma Homo sapiens 149-158 2107102-6 1990 Cell free translation assay using RNAs isolated from NNA cells which are induced by poly I:poly C in the presence of CHX reveals that in these RNAs, IFN gamma mRNA does not exist. Cycloheximide 117-120 interferon gamma Homo sapiens 149-158 1689317-7 1990 In the absence of dibutyryl cAMP it accelerates the transition from epithelial to spindle-shaped cells, whereas in the presence of cyclic AMP interferon-gamma increases the binding of PBMLs to both epithelioid and spindle-shaped MEC and the endocytic activity of the endothelial cells. Cyclic AMP 131-141 interferon gamma Homo sapiens 142-158 2105168-1 1990 Previous studies have shown that 1,25-dihydroxyvitamin D3 (calcitriol) is a macrophage-derived cytokine and a potent inhibitor of IL-2 and interferon-gamma (IFN-gamma) production and T lymphocyte proliferation. Calcitriol 33-57 interferon gamma Homo sapiens 139-155 2105168-1 1990 Previous studies have shown that 1,25-dihydroxyvitamin D3 (calcitriol) is a macrophage-derived cytokine and a potent inhibitor of IL-2 and interferon-gamma (IFN-gamma) production and T lymphocyte proliferation. Calcitriol 33-57 interferon gamma Homo sapiens 157-166 2105168-1 1990 Previous studies have shown that 1,25-dihydroxyvitamin D3 (calcitriol) is a macrophage-derived cytokine and a potent inhibitor of IL-2 and interferon-gamma (IFN-gamma) production and T lymphocyte proliferation. Calcitriol 59-69 interferon gamma Homo sapiens 139-155 2105168-1 1990 Previous studies have shown that 1,25-dihydroxyvitamin D3 (calcitriol) is a macrophage-derived cytokine and a potent inhibitor of IL-2 and interferon-gamma (IFN-gamma) production and T lymphocyte proliferation. Calcitriol 59-69 interferon gamma Homo sapiens 157-166 2105168-8 1990 Northern blot analysis demonstrated the decrease in IFN-gamma and TfR mRNA accumulation with calcitriol treatment was unaffected by exogenous IL-2. Calcitriol 93-103 interferon gamma Homo sapiens 52-61 2105274-1 1990 In a previous study the adjuvant action of a monophosphoryl lipid A, a nontoxic derivative of endotoxic lipopolysaccharide (LPS), was found to be negated by a monoclonal anti-gamma interferon (anti-IFN-gamma) antibody. Lipid A 60-67 interferon gamma Homo sapiens 198-207 2105274-7 1990 It was concluded that the enhancement induced by the adjuvants LPS, poly(A)-poly(U), and murabutide is mediated in part by their action on T cells resulting in release of IFN-gamma suggesting activation of a common transmembrane signal. Poly A-U 68-83 interferon gamma Homo sapiens 171-180 2105274-7 1990 It was concluded that the enhancement induced by the adjuvants LPS, poly(A)-poly(U), and murabutide is mediated in part by their action on T cells resulting in release of IFN-gamma suggesting activation of a common transmembrane signal. murabutide 89-99 interferon gamma Homo sapiens 171-180 2136857-6 1990 Recovery of hIFN-gamma binding of deglycosylated receptors was achieved upon affinity purification and adsorption to nitrocellulose membranes, indicating that the carbohydrate side chains themselves do not directly contribute to the ligand binding epitope but seem to be essential for appropriate conformation of the receptor protein in the cell membrane. Carbohydrates 163-175 interferon gamma Homo sapiens 12-22 1688583-3 1990 Antibodies specific to IFN-gamma were affinity purified both from sera taken from healthy individuals and sera from viral-infected patients, by using a rIFN-gamma-coupled CNBr-activated Sepharose 4B column. Sepharose 186-195 interferon gamma Homo sapiens 23-32 2104904-1 1990 We have previously shown that transfection of a plasmid clone containing full length human IFN-gamma genomic DNA into a murine T-lymphoblastoid line is followed by basal expression of the transfected gene, with increased transcription occurring upon stimulation of the cells with either phorbol ester or IL-2. Phorbol Esters 287-300 interferon gamma Homo sapiens 91-100 2156322-3 1990 We hypothesized that U937 and THP-1 cells would release LTB4, LTC4, and LTD4 in response to stimulation with the non-physiologic agonist, calcium ionophore A23187 and that preincubation with IFN-gamma or PMA might alter leukotriene release by these cells. Calcium 138-145 interferon gamma Homo sapiens 191-200 2156322-3 1990 We hypothesized that U937 and THP-1 cells would release LTB4, LTC4, and LTD4 in response to stimulation with the non-physiologic agonist, calcium ionophore A23187 and that preincubation with IFN-gamma or PMA might alter leukotriene release by these cells. Calcimycin 156-162 interferon gamma Homo sapiens 191-200 1695503-2 1990 The effects of interleukin-1 alpha and -1 beta, tumour necrosis factor-alpha and interferon-gamma on PGE and cAMP production by periodontal ligament fibroblasts were studied. Prostaglandins E 101-104 interferon gamma Homo sapiens 81-97 2198842-3 1990 We have shown that growth hormone mimics one action of interferon-gamma (IFN-gamma) by augmenting the production of superoxide anion by macrophages and neutrophils. Superoxides 116-132 interferon gamma Homo sapiens 55-71 2198842-3 1990 We have shown that growth hormone mimics one action of interferon-gamma (IFN-gamma) by augmenting the production of superoxide anion by macrophages and neutrophils. Superoxides 116-132 interferon gamma Homo sapiens 73-82 2104779-0 1990 Unconjugated pteridines and the activation of macrophages by interferon gamma. Pteridines 13-23 interferon gamma Homo sapiens 61-77 2176907-5 1990 In differentiated HL-60 and U 937 cells, the oxidative metabolism increases in parallel with Cyt b specific contents, both being enhanced by the addition of IFN gamma to the RA treatment. Tretinoin 174-176 interferon gamma Homo sapiens 157-166 2124513-4 1990 Analysis of the supernatant culture medium after 72 h preincubation demonstrated that HM-BP induced release of interferon gamma (IFN gamma) from T cells (preferentially from CD3+CD4+ cells) and of tumour necrosis factor alpha (TNF alpha) from monocytes/macrophages. hm-bp 86-91 interferon gamma Homo sapiens 111-127 1707382-4 1990 P19 polypeptide, which is derived from recombinant HBcAg particle (rHBcAg), increased IFN-gamma production in patients with CAH, but its effect was weaker than that of rHBcAg. rhbcag 67-73 interferon gamma Homo sapiens 86-95 2124513-4 1990 Analysis of the supernatant culture medium after 72 h preincubation demonstrated that HM-BP induced release of interferon gamma (IFN gamma) from T cells (preferentially from CD3+CD4+ cells) and of tumour necrosis factor alpha (TNF alpha) from monocytes/macrophages. hm-bp 86-91 interferon gamma Homo sapiens 129-138 2124513-5 1990 Release of IFN gamma was the crucial step for activation of NK cytotoxicity since enhancement of NK cytotoxicity during pretreatment of PBMC or PNAC with HM-BP was completely blocked in the presence of anti-IFN gamma antibodies. hm-bp 154-159 interferon gamma Homo sapiens 11-20 2124513-5 1990 Release of IFN gamma was the crucial step for activation of NK cytotoxicity since enhancement of NK cytotoxicity during pretreatment of PBMC or PNAC with HM-BP was completely blocked in the presence of anti-IFN gamma antibodies. hm-bp 154-159 interferon gamma Homo sapiens 207-216 2126984-0 1990 The in vitro development of cytotoxicity in response to granulocyte/macrophage-colony-stimulating factor or interferon gamma in the peripheral blood monocytes of patients with solid tumors: modulation by arachidonic acid metabolic inhibitors. Arachidonic Acid 204-220 interferon gamma Homo sapiens 108-124 2126984-4 1990 Indomethacin, a cyclooxygenase inhibitor, significantly augmented IFN gamma-elicited cytotoxicity in cancer patient monocytes, but not in normal monocytes. Indomethacin 0-12 interferon gamma Homo sapiens 66-75 2126984-6 1990 Nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor, was found to suppress cytotoxicity in response to IFN gamma and GM-CSF in both cancer patient monocytes and normal monocytes. Masoprocol 0-25 interferon gamma Homo sapiens 110-119 2126984-6 1990 Nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor, was found to suppress cytotoxicity in response to IFN gamma and GM-CSF in both cancer patient monocytes and normal monocytes. Masoprocol 27-31 interferon gamma Homo sapiens 110-119 2136700-3 1990 IFN-gamma (0.05-50 ng/ml) pretreatment of SKCO1 cells for 24 h decreased specific binding of 125I-IFN-beta ser by 35-60%. Serine 107-110 interferon gamma Homo sapiens 0-9 2136700-5 1990 In contrast, pretreatment of SKCO1 cells with IFN-beta ser (5 ng/ml) resulted in slight (10-35%) increases in 125I-IFN-gamma-specific binding. Serine 55-58 interferon gamma Homo sapiens 115-124 2136700-6 1990 Scatchard analysis of binding data obtained following 24-h treatment with 5 ng/ml IFN-beta ser showed a decrease in binding affinity (control cells, Kd = 28 +/- 7 pM; IFN-beta ser-treated cells, Kd = 38 +/- 7 pM, n = 2) and a 32% increase in IFN-gamma receptor sites (receptor number/control cell = 4257 +/- 464, receptor number/IFN-beta ser-treated cell = 5570 +/- 730; n = 2). Serine 91-94 interferon gamma Homo sapiens 242-251 2136700-7 1990 125I-IFN-gamma internalization studies performed at 37 degrees C confirmed the cell surface binding assays; IFN-beta ser-treated cells internalized 30-50% more labeled IFN-gamma than untreated cells. Serine 117-120 interferon gamma Homo sapiens 5-14 2136700-7 1990 125I-IFN-gamma internalization studies performed at 37 degrees C confirmed the cell surface binding assays; IFN-beta ser-treated cells internalized 30-50% more labeled IFN-gamma than untreated cells. Serine 117-120 interferon gamma Homo sapiens 168-177 2107194-6 1990 PGE2 inhibited the IFN-gamma production by PBMCs, and the sensitivity of PBMCs to PGE2 was increased in the patients and controls over 60 years of age. Dinoprostone 0-4 interferon gamma Homo sapiens 19-28 2112569-0 1990 In vitro effects of two gold compounds, and D-penicillamine on the production of interferon gamma. Penicillamine 44-59 interferon gamma Homo sapiens 81-97 1982067-5 1990 IFN-gamma induced a rapid activation of phospholipase C, leading to a breakdown of phosphoinositoldiphosphate (PIP2) into diacyglycerol (DAG) and inositoltriphosphate (IP3). phosphoinositoldiphosphate 83-109 interferon gamma Homo sapiens 0-9 1982067-5 1990 IFN-gamma induced a rapid activation of phospholipase C, leading to a breakdown of phosphoinositoldiphosphate (PIP2) into diacyglycerol (DAG) and inositoltriphosphate (IP3). Phosphatidylinositol 4,5-Diphosphate 111-115 interferon gamma Homo sapiens 0-9 1982067-5 1990 IFN-gamma induced a rapid activation of phospholipase C, leading to a breakdown of phosphoinositoldiphosphate (PIP2) into diacyglycerol (DAG) and inositoltriphosphate (IP3). diacyglycerol 122-135 interferon gamma Homo sapiens 0-9 1982067-5 1990 IFN-gamma induced a rapid activation of phospholipase C, leading to a breakdown of phosphoinositoldiphosphate (PIP2) into diacyglycerol (DAG) and inositoltriphosphate (IP3). dag 137-140 interferon gamma Homo sapiens 0-9 1982067-5 1990 IFN-gamma induced a rapid activation of phospholipase C, leading to a breakdown of phosphoinositoldiphosphate (PIP2) into diacyglycerol (DAG) and inositoltriphosphate (IP3). inositoltriphosphate 146-166 interferon gamma Homo sapiens 0-9 1982067-5 1990 IFN-gamma induced a rapid activation of phospholipase C, leading to a breakdown of phosphoinositoldiphosphate (PIP2) into diacyglycerol (DAG) and inositoltriphosphate (IP3). Inositol 1,4,5-Trisphosphate 168-171 interferon gamma Homo sapiens 0-9 1982067-9 1990 An inhibitor of calcium calmodulin, W7, decreased the IFN-gamma induced ICAM-1 expression, and addition of calcium ionophore to endothelial cells could replace IFN-gamma in the up-regulation of ICAM-1. Calcium 16-23 interferon gamma Homo sapiens 54-63 1982067-10 1990 Finally, IFN-gamma caused a significant increase in the calcium flux of endothelial cells. Calcium 56-63 interferon gamma Homo sapiens 9-18 2117000-6 1990 IFN-gamma exerted an antagonistic effect on the TGF-beta-induced stimulation of GAG synthesis. Glycosaminoglycans 80-83 interferon gamma Homo sapiens 0-9 2169174-0 1990 Mechanism of production of interferon-gamma: role of arachidonic acid metabolites. Arachidonic Acid 53-69 interferon gamma Homo sapiens 27-43 2169174-2 1990 Both prostaglandins E2 (PGE2) and leukotrienes B4 (LTB4) were produced after macrophage activation stimulated by galactose oxidase (GO) and Staphylococcal enterotoxin B (SEB), two well known inducers of IFN-gamma. Dinoprostone 5-22 interferon gamma Homo sapiens 203-212 2169174-2 1990 Both prostaglandins E2 (PGE2) and leukotrienes B4 (LTB4) were produced after macrophage activation stimulated by galactose oxidase (GO) and Staphylococcal enterotoxin B (SEB), two well known inducers of IFN-gamma. Leukotriene B4 34-49 interferon gamma Homo sapiens 203-212 2169174-2 1990 Both prostaglandins E2 (PGE2) and leukotrienes B4 (LTB4) were produced after macrophage activation stimulated by galactose oxidase (GO) and Staphylococcal enterotoxin B (SEB), two well known inducers of IFN-gamma. Leukotriene B4 51-55 interferon gamma Homo sapiens 203-212 2169174-4 1990 The results of these experiments showed that aspirin and indomethacin cause a marked increase of IFN-gamma production by GO- and SEB-activated PBMC. Aspirin 45-52 interferon gamma Homo sapiens 97-106 2169174-4 1990 The results of these experiments showed that aspirin and indomethacin cause a marked increase of IFN-gamma production by GO- and SEB-activated PBMC. Indomethacin 57-69 interferon gamma Homo sapiens 97-106 2169174-6 1990 Moreover, whereas the addition of exogenous PGE2 reduces IFN gamma production, the addition of exogenous LTB4 does not affect IFN-gamma production. Dinoprostone 44-48 interferon gamma Homo sapiens 57-66 2169174-7 1990 Taken together these findings indicate that arachidonic acid metabolites, produced during mitogenic activation, are involved in the regulation of IFN-gamma production and suggest that, in our system, LTB4 exerts a positive modulating signal while PGE2 represents a negative signal. Arachidonic Acid 44-60 interferon gamma Homo sapiens 146-155 2169174-7 1990 Taken together these findings indicate that arachidonic acid metabolites, produced during mitogenic activation, are involved in the regulation of IFN-gamma production and suggest that, in our system, LTB4 exerts a positive modulating signal while PGE2 represents a negative signal. Dinoprostone 247-251 interferon gamma Homo sapiens 146-155 2107194-7 1990 The addition of indomethacin resulted in an increase in IFN-gamma production by PBMCs. Indomethacin 16-28 interferon gamma Homo sapiens 56-65 2107194-8 1990 These results suggest that the increased production of PGE2 and/or increased sensitivity to PGE2 are responsible for the decreased IFN-gamma production in patients with cervical cancer. Dinoprostone 55-59 interferon gamma Homo sapiens 131-140 2107194-8 1990 These results suggest that the increased production of PGE2 and/or increased sensitivity to PGE2 are responsible for the decreased IFN-gamma production in patients with cervical cancer. Dinoprostone 92-96 interferon gamma Homo sapiens 131-140 2172660-0 1990 Difference in effects of interferon-alpha and interferon-gamma on the induction of differentiation of retinoic acid-treated acute myeloid leukemia cells in primary culture. Tretinoin 102-115 interferon gamma Homo sapiens 46-62 2172660-3 1990 In particular, interferon-alpha enhanced granulocytic differentiation and interferon-gamma induced mono-macrophage differentiation of promyelocytic leukemic cells in the presence of RA. Tretinoin 182-184 interferon gamma Homo sapiens 74-90 2117103-4 1990 In humans at least some effects of IFN-gamma on macrophages may be mediated via 1,25-dihydroxyvitamin D3. Calcitriol 80-104 interferon gamma Homo sapiens 35-44 2090873-7 1990 When the monocytes were coincubated with IFN-gamma (human but not mouse) and the immunomodulators, IL 1, TNF, and PGE2 were secreted at all test groups. Dinoprostone 114-118 interferon gamma Homo sapiens 41-50 2117183-2 1990 It was found that BV enhances the natural killer (NK) activity of PBMC and increases their spontaneous and phytohemagglutin (PHA)-induced production of tumor-necrosis factor--alpha and interleukin-2 as well as the PHA-stimulated production of interferon-gamma. phytohemagglutin 107-123 interferon gamma Homo sapiens 243-259 1983341-0 1990 1,25-Dihydroxyvitamin D3 decreases the interferon-gamma (IFN-gamma) induced HLA-DR expression but not intercellular adhesion molecule 1 (ICAM-1) on human keratinocytes. Calcitriol 0-24 interferon gamma Homo sapiens 39-66 2107536-11 1990 The cloned product interferon gamma has been reported to improve superoxide generation, bactericidal activity, and immunoreactive cytochrome b in some CGD neutrophils and monocytes, both in vitro and in vivo. Superoxides 65-75 interferon gamma Homo sapiens 19-35 3129197-6 1988 Because the oxidation of galactose residues on cell surface structures is considered a general feature of lymphocyte activation whatever the inducer, it seems that MBF may be a mediator involved in mitogenic activation of T cells leading to IFN-gamma production and proliferation. Galactose 25-34 interferon gamma Homo sapiens 241-250 33770643-11 2021 In conclusion, serum cytokine level, such as TGF-beta1, TNF-alpha, and IFN-gamma, could be a potential prognostic biomarker for breast cancer patients with bone metastasis treated with ZA and taxane-based chemotherapy. Zoledronic Acid 185-187 interferon gamma Homo sapiens 71-80 33770643-11 2021 In conclusion, serum cytokine level, such as TGF-beta1, TNF-alpha, and IFN-gamma, could be a potential prognostic biomarker for breast cancer patients with bone metastasis treated with ZA and taxane-based chemotherapy. taxane 192-198 interferon gamma Homo sapiens 71-80 33971957-12 2021 The M (IFNG/LPS)-induced phenotype was associated with a switch from endogenous fatty acid synthesis to glycolysis-dominated cell metabolism and increased pro-inflammatory cytokine production. Fatty Acids 80-90 interferon gamma Homo sapiens 7-11 33943031-5 2021 Pretreatment screening tests had been performed using the T-SPOT.TB assay, which quantifies the number of interferon-gamma-releasing T cells (as immunospots) in response to phytohemagglutinin and tuberculosis-specific antigen stimulation. Terbium 65-67 interferon gamma Homo sapiens 106-122 33972124-9 2021 The secretion of IFN-gamma from splenocyte re-stimulation and an elevated ratio of serum IgG2a to IgG1 indicated that the immune response induced by the HBc VLPs/HRO24 mixture was Th1-biased. hro24 162-167 interferon gamma Homo sapiens 17-26 33972011-7 2021 DHA and EPA markedly inhibited IFN-gamma secretion, while only EPA reduced TNF-alpha secretion. Docosahexaenoic Acids 0-3 interferon gamma Homo sapiens 31-40 33972011-4 2021 DHA or EPA treatment lowered the number of differentiated IFN-gamma-positive cells and inhibited the secretion of IFN-gamma, whereas only DHA increased IL-2 and reduced TNF-alpha secretion. Docosahexaenoic Acids 0-3 interferon gamma Homo sapiens 58-67 33972011-7 2021 DHA and EPA markedly inhibited IFN-gamma secretion, while only EPA reduced TNF-alpha secretion. Eicosapentaenoic Acid 8-11 interferon gamma Homo sapiens 31-40 33972011-4 2021 DHA or EPA treatment lowered the number of differentiated IFN-gamma-positive cells and inhibited the secretion of IFN-gamma, whereas only DHA increased IL-2 and reduced TNF-alpha secretion. Docosahexaenoic Acids 0-3 interferon gamma Homo sapiens 114-123 33769968-8 2021 Functional analysis of genes with a minimum of two DMPs showed involvement in antigen binding, transcriptional regulation, cell adhesion, IFN-gamma pathway, type I IFN pathway, antigen presentation, EB virus infection, human T-lymphotropic virus type 1 virus infection, and metabolic disease-related pathways. Unithiol 51-55 interferon gamma Homo sapiens 138-147 33972011-4 2021 DHA or EPA treatment lowered the number of differentiated IFN-gamma-positive cells and inhibited the secretion of IFN-gamma, whereas only DHA increased IL-2 and reduced TNF-alpha secretion. Eicosapentaenoic Acid 7-10 interferon gamma Homo sapiens 58-67 33972011-4 2021 DHA or EPA treatment lowered the number of differentiated IFN-gamma-positive cells and inhibited the secretion of IFN-gamma, whereas only DHA increased IL-2 and reduced TNF-alpha secretion. Eicosapentaenoic Acid 7-10 interferon gamma Homo sapiens 114-123 33764440-7 2021 When dHCASMCs were incubated with different cytokines, higher PML-levels were observed only after IFN-gamma stimulation, while the expression of differentiation markers decreased. dhcasmcs 5-13 interferon gamma Homo sapiens 98-107 33588236-3 2021 Here, we show that phosphodiesterase-5 inhibitors, sildenafil and tadalafil, promote IFN-gamma and IL-4 production in iNKT cells in a cGMP-PKG pathway dependent manner. Sildenafil Citrate 51-61 interferon gamma Homo sapiens 85-94 33588236-3 2021 Here, we show that phosphodiesterase-5 inhibitors, sildenafil and tadalafil, promote IFN-gamma and IL-4 production in iNKT cells in a cGMP-PKG pathway dependent manner. Tadalafil 66-75 interferon gamma Homo sapiens 85-94 33588236-3 2021 Here, we show that phosphodiesterase-5 inhibitors, sildenafil and tadalafil, promote IFN-gamma and IL-4 production in iNKT cells in a cGMP-PKG pathway dependent manner. Cyclic GMP 134-138 interferon gamma Homo sapiens 85-94 33810258-1 2021 BACKGROUND: Seven weeks of high-dose vitamin D treatment decreases intestinal IL17A and IFN-gamma mRNA expression in active Crohn"s disease (CD). Vitamin D 37-46 interferon gamma Homo sapiens 88-97 33802081-6 2021 However, CFA-stimulated moDCs led to higher lymphoproliferation, with increased IFN-gamma and TNF-alpha in the cells from the patients with active PCM compared with gp43. 3-chloro-4-fluoroaniline 9-12 interferon gamma Homo sapiens 80-89 33780033-9 2021 Vitamin K2 alone tended to suppress the secretion of IL-17, IFN-gamma and TNF-alpha from the activated PBMCs of RA patients with smaller influences on the cytokine productions from healthy PBMCs. Vitamin K 2 0-10 interferon gamma Homo sapiens 60-69 33804896-5 2021 Priming of the ASC with inflammatory factors TNFalpha and IFNgamma enhances ASC-CS ability to suppress lung injury. asc-cs 76-82 interferon gamma Homo sapiens 58-66 33776472-11 2021 The levels of IL-2, IFN-gamma and TNFalpha in nITP group and cITP group were significantly higher than those in healthy control group (p < 0.01, p < 0.05; p < 0.01, p < 0.05; p < 0.05, p < 0.05), and the level of IL-10 in nITP group was significantly higher than that in pITP group (p < 0.05). 7-(4'-(2-nitroimidazole-1-yl)butyl)theophylline 46-50 interferon gamma Homo sapiens 20-29 33803334-8 2021 Butyrate, but not acetate, propionate, or succinate, ameliorated the TNF-alpha/IFN-gamma-induced decrease in TEER. Butyrates 0-8 interferon gamma Homo sapiens 79-88 33767693-0 2021 Use of IFNgamma/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock. Hydrocortisone 49-63 interferon gamma Homo sapiens 7-15 33767693-10 2021 We propose IFNgamma/IL10 as a molecular marker supporting the decision to administer hydrocortisone to patients in septic shock. Hydrocortisone 85-99 interferon gamma Homo sapiens 11-19 33803334-10 2021 Butyrate significantly attenuated the upregulation of claudin-2 induced by TNF-alpha/IFN-gamma. Butyrates 0-8 interferon gamma Homo sapiens 85-94 33807944-3 2021 PDE4 blocking can lead to increased levels of intracellular cAMP, which results in down-regulation of inflammatory responses by reducing the expression of tumor necrosis factor (TNF), interleukin (IL)-23, IL-17, interferon-gamma, while increasing regulatory cytokines, such as IL-10. Cyclic AMP 60-64 interferon gamma Homo sapiens 212-228 33814413-6 2021 Propranolol significantly reduced the production of IL-2, IL-10 and IFN-gamma in PHA-stimulated Jurkat cells (p<0.05). Propranolol 0-11 interferon gamma Homo sapiens 68-77 29331905-6 2018 In this system, IL-4, an anti-inflammatory cytokine, was loaded in TNT and IFN-gamma, a pro-inflammatory cytokine, was located between two hydrogel layers of chitosan/beta-glycerophosphate disodium and carboxymethyl chitosan/genipin. beta-glycerophosphoric acid 167-197 interferon gamma Homo sapiens 75-84 30384869-0 2018 [Glycyrrhizin inhibits IFN-gamma-induced CXCL10 by suppressing the JAK/STAT1 signal pathway in HaCaT cells]. Glycyrrhizic Acid 1-13 interferon gamma Homo sapiens 23-32 30384869-1 2018 Objective To detect the effect of glycyrrhizin (GL) on the expression of CXCL10 induced by IFN-gamma in HaCaT cells. Glycyrrhizic Acid 34-46 interferon gamma Homo sapiens 91-100 30384869-1 2018 Objective To detect the effect of glycyrrhizin (GL) on the expression of CXCL10 induced by IFN-gamma in HaCaT cells. Glycyrrhizic Acid 48-50 interferon gamma Homo sapiens 91-100 30384869-8 2018 Results GL decreased IFN-gamma-induced keratinocyte disruption. Glycyrrhizic Acid 8-10 interferon gamma Homo sapiens 21-30 30384869-10 2018 Both GL and JAK1/2 inhibitor CYT387 down-regulated the expression of CXCL10 in HaCaT cells induced by IFN-gamma. Glycyrrhizic Acid 5-7 interferon gamma Homo sapiens 102-111 30384869-13 2018 Conclusion GL inhibits the activation of IFN-gamma- mediated JAK/STAT1 signaling, thereby reducing CXCL10 level in HaCaT cells. Glycyrrhizic Acid 11-13 interferon gamma Homo sapiens 41-50 29331905-6 2018 In this system, IL-4, an anti-inflammatory cytokine, was loaded in TNT and IFN-gamma, a pro-inflammatory cytokine, was located between two hydrogel layers of chitosan/beta-glycerophosphate disodium and carboxymethyl chitosan/genipin. carboxymethyl-chitosan 202-224 interferon gamma Homo sapiens 75-84 26335632-8 2015 IL-6 and IFNgamma were downregulated in HMGECs treated for 72 h with DHA and EPA. Docosahexaenoic Acids 69-72 interferon gamma Homo sapiens 9-17 26335632-8 2015 IL-6 and IFNgamma were downregulated in HMGECs treated for 72 h with DHA and EPA. Eicosapentaenoic Acid 77-80 interferon gamma Homo sapiens 9-17 25526818-4 2015 Here we report the effect of salmeterol (Sal), a selective ss2AR agonist, on IFN-gamma(+) CD4 and IFN-gamma(+) CD8 T cells following stimulation with Cytomegalovirus lysate (CMVL-strain AD169) or individual peptides spanning the entire region of the HCMV pp65 protein (pp65). Salmeterol Xinafoate 29-39 interferon gamma Homo sapiens 77-86 24504444-10 2014 Furthermore, secretion of interferon-gamma and interleukin-9 by CD4(+) T cells was significantly lower in samples obtained during vemurafenib treatment compared with baseline samples. Vemurafenib 130-141 interferon gamma Homo sapiens 26-42 24011630-9 2013 Hence we conclude that IFN-gamma or TNF-alpha response to these ESAT-6 peptides has the potential to differentiate between active and latent TB in our population. Terbium 141-143 interferon gamma Homo sapiens 23-32 25526818-4 2015 Here we report the effect of salmeterol (Sal), a selective ss2AR agonist, on IFN-gamma(+) CD4 and IFN-gamma(+) CD8 T cells following stimulation with Cytomegalovirus lysate (CMVL-strain AD169) or individual peptides spanning the entire region of the HCMV pp65 protein (pp65). Salmeterol Xinafoate 41-44 interferon gamma Homo sapiens 77-86 25526818-4 2015 Here we report the effect of salmeterol (Sal), a selective ss2AR agonist, on IFN-gamma(+) CD4 and IFN-gamma(+) CD8 T cells following stimulation with Cytomegalovirus lysate (CMVL-strain AD169) or individual peptides spanning the entire region of the HCMV pp65 protein (pp65). Salmeterol Xinafoate 41-44 interferon gamma Homo sapiens 98-107 25526818-6 2015 The results show that Sal reduced the percentage of IFN-gamma(+) CD4 and IFN-gamma(+) CD8 T cells both when applied directly to isolated T cells, and indirectly via treatment of APC. Salmeterol Xinafoate 22-25 interferon gamma Homo sapiens 52-61 25526818-6 2015 The results show that Sal reduced the percentage of IFN-gamma(+) CD4 and IFN-gamma(+) CD8 T cells both when applied directly to isolated T cells, and indirectly via treatment of APC. Salmeterol Xinafoate 22-25 interferon gamma Homo sapiens 73-82 15626737-0 2005 Iron regulates T-lymphocyte sensitivity to the IFN-gamma/STAT1 signaling pathway in vitro and in vivo. Iron 0-4 interferon gamma Homo sapiens 47-56 21534035-4 2011 The levels of several Th1 cytokines, including interferon-gamma and tumor necrosis factor-alpha, are significantly increased after CBG treatment, whereas the levels of the Th2 cytokine interleukin-4 and interleukin-10 are significantly decreased. cinobufagin 131-134 interferon gamma Homo sapiens 47-95 15626737-3 2005 Here we show that iron uptake mediated by the transferrin receptor (TfR) delivers a signal that leads to IFN-gammaR2 internalization and thus plays an essential role in attenuating activation of the IFN-gamma/STAT1 pathway in human T lymphocytes. Iron 18-22 interferon gamma Homo sapiens 105-114 15626737-5 2005 Deferoxamine (DFO), an iron-chelating agent, up-regulated IFN-gammaR2 surface expression and reinstated IFN-gamma/STAT1 activation in proliferating T lymphocytes. Deferoxamine 0-12 interferon gamma Homo sapiens 58-67 12827002-5 2003 RESULTS: uFA patients had a higher density of IFN-gamma positive cells in the lamina propria than did tFA patients and controls (P = 0.053 and P = 0.018). ufa 9-12 interferon gamma Homo sapiens 46-55 15626737-5 2005 Deferoxamine (DFO), an iron-chelating agent, up-regulated IFN-gammaR2 surface expression and reinstated IFN-gamma/STAT1 activation in proliferating T lymphocytes. Deferoxamine 14-17 interferon gamma Homo sapiens 58-67 15626737-6 2005 Resistance of malignant T cells to the antiproliferative effect of IFN-gamma in vitro was abrogated by addition of DFO. Deferoxamine 115-118 interferon gamma Homo sapiens 67-76 15626737-7 2005 Conversely, iron inhibited IFN-gamma-induced apoptosis in malignant T cells in serum-free conditions. Iron 12-16 interferon gamma Homo sapiens 27-36 15626737-9 2005 These data provide valuable insights for novel therapeutic approaches aimed at reinstating the IFN-gamma/STAT1 apoptotic signaling pathway in autoreactive or neoplastic T cells by means of iron chelation. Iron 189-193 interferon gamma Homo sapiens 95-104 12810348-4 2003 Histamine enhances the secretion of Th2 cytokines such as IL-4 (interleukin-4), IL-5, IL-10 and IL-13 and inhibits the production of Th1 cytokines IL-2 and IFNgamma (interferon-gamma) and monokine IL-12. Histamine 0-9 interferon gamma Homo sapiens 156-164 12810348-4 2003 Histamine enhances the secretion of Th2 cytokines such as IL-4 (interleukin-4), IL-5, IL-10 and IL-13 and inhibits the production of Th1 cytokines IL-2 and IFNgamma (interferon-gamma) and monokine IL-12. Histamine 0-9 interferon gamma Homo sapiens 166-182 12810348-7 2003 We have also demonstrated that the Jak-STAT (Janus kinase-signal transducers and activators of transcription) pathway is involved in histamine-mediated regulation of Th2 cytokines IL-5, IL-10, IL-13 and Th1 cytokine IFNgamma. Histamine 133-142 interferon gamma Homo sapiens 216-224 11222479-3 2001 This study investigates the effect of interferon (IFN)-gamma on VLDL receptor expression in phorbol-12-myristate-13-acetate (PMA)-treated THP-1, HL-60 macrophages, and human monocyte-derived macrophages. Tetradecanoylphorbol Acetate 92-123 interferon gamma Homo sapiens 38-60 11222479-3 2001 This study investigates the effect of interferon (IFN)-gamma on VLDL receptor expression in phorbol-12-myristate-13-acetate (PMA)-treated THP-1, HL-60 macrophages, and human monocyte-derived macrophages. Tetradecanoylphorbol Acetate 125-128 interferon gamma Homo sapiens 38-60 11222479-12 2001 (125)I-beta-VLDL degradation study and oil red O staining showed that IFN-gamma significantly inhibited foam cell formation after the uptake of beta-VLDL. oil red O 39-48 interferon gamma Homo sapiens 70-79 7865624-6 1994 The data indicate a role of the immune system and particularly of endogenously formed cytokines, like interferon-gamma and tumour necrosis factor-alpha, effecting tryptophan and neopterin metabolism in patients with acute Lyme neuroborreliosis. Tryptophan 163-173 interferon gamma Homo sapiens 102-151 7880978-7 1994 IL-2 and IFN-gamma mRNA were detectable in PBMC as early as 3 hours after in vitro stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 100-103 interferon gamma Homo sapiens 9-18 7865624-6 1994 The data indicate a role of the immune system and particularly of endogenously formed cytokines, like interferon-gamma and tumour necrosis factor-alpha, effecting tryptophan and neopterin metabolism in patients with acute Lyme neuroborreliosis. Neopterin 178-187 interferon gamma Homo sapiens 102-151 7880978-7 1994 IL-2 and IFN-gamma mRNA were detectable in PBMC as early as 3 hours after in vitro stimulation with PMA and ionomycin. Ionomycin 108-117 interferon gamma Homo sapiens 9-18 34699930-11 2022 However only treatment with TAT resulted in regulatory CD4 T-cell drop and transient increased production of IL-2, CCL-5 and IFNgamma within the tumor. Triethylenemelamine 28-31 interferon gamma Homo sapiens 125-133 34933240-4 2022 Our results demonstrated that LTBI individuals with SARS-CoV-2 seropositivity (LTBI+/IgG +) were associated with increased levels of unstimulated and TB-antigen stimulated IFNgamma, IL-2, TNFalpha, IL-17, IL-1beta, IL-6, IL-12, IL-4, CXCL1, CXCL9 and CXCL10 when compared to those without seropositivity (LTBI+/IgG-). Terbium 150-152 interferon gamma Homo sapiens 172-180 34862988-5 2022 Lithium counteracted these effects, increasing inhibitory GSK3betaS9 phosphorylation and reducing STAT1S727 and STAT3Y705 phosphorylation levels in IFN-gamma treated cells. Lithium 0-7 interferon gamma Homo sapiens 148-157 34896691-2 2022 Dose-dependent treatment with HM (10, 50, 100, 200 mug/mL) inhibited the expression of Interleukin-2 (IL-2) and Tumor necrosis factor- alpha (TNF-alpha) in inflammatory induced HaCaT and Jurkat cells with inflammation caused by TNF/IFN-gamma and PMA/A23187. medrysone 30-32 interferon gamma Homo sapiens 232-241 34808332-0 2022 25-Hydroxycholesterol suppress IFN-gamma-induced inflammation in microglia by disrupting lipid raft formation and caveolin-mediated signaling endosomes. 25-hydroxycholesterol 0-21 interferon gamma Homo sapiens 31-40 34952465-10 2022 In vivo study showed that lenalidomide inhibited pro-inflammatory cytokines TNF-alpha and IL-6 while enhanced anti-fibrotic cytokines IFN-gamma and IL-10 in bleomycin-induced inflammation model, and attenuated pulmonary fibrosis and collagen deposition in the following fibrosis stage. Lenalidomide 26-38 interferon gamma Homo sapiens 134-143 34972043-7 2022 MSU induced an increase in IFN-gamma and IL-22 in all studied groups. Uric Acid 0-3 interferon gamma Homo sapiens 27-36 34808332-5 2022 The present study evaluated the anti-inflammatory mechanisms of oxysterols, blood brain barrier (BBB) penetrable bioactive lipids, revealing that this intervention suppresses neuroinflammation by disrupting membrane lipid raft formation and caveolae-mediated endosomal IFN-gamma signaling. Oxysterols 64-74 interferon gamma Homo sapiens 269-278 34808332-8 2022 25-HC repressed IFN-gamma induction of Cav-1 expression in microglia, and subsequently suppressed the chronic inflammatory response. 25-hydroxycholesterol 0-5 interferon gamma Homo sapiens 16-25 34753772-0 2022 Inhibition of FGFR reactivates IFNgamma signaling in tumor cells to enhance the combined antitumor activity of lenvatinib with anti-PD-1 antibodies. lenvatinib 111-121 interferon gamma Homo sapiens 31-39 34543449-6 2022 In MS patients, lenabasum also reduced activation marker CD25 and inhibited IL-2 production from both T cell subsets and IFN-gamma and IL-17 from committed Th1 and Th17 cells, respectively. lenabasum 16-25 interferon gamma Homo sapiens 121-130 34922004-5 2022 Treatment with GSK2256294 decreased the percentage of pro-inflammatory T cells producing interferon-gamma (IFNgamma), but not interleukin (IL)-17A, and decreased the amount of secreted tumor necrosis factor-alpha (TNFalpha). N-((4-cyano-2-(trifluoromethyl)phenyl)methyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexanecarboxamide 15-25 interferon gamma Homo sapiens 89-105 34922004-5 2022 Treatment with GSK2256294 decreased the percentage of pro-inflammatory T cells producing interferon-gamma (IFNgamma), but not interleukin (IL)-17A, and decreased the amount of secreted tumor necrosis factor-alpha (TNFalpha). N-((4-cyano-2-(trifluoromethyl)phenyl)methyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexanecarboxamide 15-25 interferon gamma Homo sapiens 107-115 34753772-6 2022 Flow-cytometry analysis showed that lenvatinib decreased the population of tumor-associated macrophages and increased that of interferon (IFN) gamma-positive CD8+ T cells. lenvatinib 36-46 interferon gamma Homo sapiens 126-148 34166655-9 2022 The interferon gamma (IFNG) gene, previously implicated in DR by protein-protein interactions in our GWAS, was among the top ranked genes in the nitric oxide pathway (best variant P=.0001). Nitric Oxide 145-157 interferon gamma Homo sapiens 4-20 34951955-4 2022 A multivariable model combining the TMB and IFNgamma-related gene expression robustly predicts response (89% sensitivity, 53% specificity, area under the curve (AUC), 0.84); tumors with high TMB and a high IFNgamma signature show the best response to immunotherapy. 1,2,4,5-tetramethoxybenzene 191-194 interferon gamma Homo sapiens 44-52 34166655-9 2022 The interferon gamma (IFNG) gene, previously implicated in DR by protein-protein interactions in our GWAS, was among the top ranked genes in the nitric oxide pathway (best variant P=.0001). Nitric Oxide 145-157 interferon gamma Homo sapiens 22-26 34236726-0 2022 Effects of metformin on autoimmune immunoglobins and interferon-gamma in patients with early diagnosed pemphigus vulgaris: A prospective clinical trial. Metformin 11-20 interferon gamma Homo sapiens 53-69 34864314-6 2022 Plasma levels of IFNgamma positively correlated with levels of total and LDL-cholesterol, whereas circulating IL-10 levels negatively correlated with these key lipid parameters. Cholesterol 77-88 interferon gamma Homo sapiens 17-25 34924115-10 2022 The in vitro results demonstrated that Wilforlide A suppressed LPS/IFN-gamma-induced TLR4 upregulation, IkappaBalpha degradation and NF-kappaB p65 activation. wilforlide A 39-51 interferon gamma Homo sapiens 67-76 34170488-4 2022 We aimed to study the effect of RGZ onto inflammation-induced secretion of CXCL10, IFNgamma, TNFalpha, interleukin (IL)-6 and IL-8 by human CD4 + T and DCs, and onto IFNgamma/TNFalpha-dependent signaling in human cardiomyocytes associated with chemokine release. Rosiglitazone 32-35 interferon gamma Homo sapiens 83-91 34170488-8 2022 In human cardiomyocytes, RGZ impaired IFNgamma/TNFalpha signal transduction, blocking the phosphorylation/nuclear translocation of signal transducer and activator of transcription 1 (Stat1) and nuclear factor-kB (NF-kB), in association with a significant decrease in CXCL10 expression, IL-6 and IL-8 release. Rosiglitazone 25-28 interferon gamma Homo sapiens 38-46 34979203-4 2022 Our results showed that BPS exposure significantly increased the production of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and interleukin-17A (IL-17A). bis(4-hydroxyphenyl)sulfone 24-27 interferon gamma Homo sapiens 158-174 34979203-4 2022 Our results showed that BPS exposure significantly increased the production of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and interleukin-17A (IL-17A). bis(4-hydroxyphenyl)sulfone 24-27 interferon gamma Homo sapiens 176-185 34719371-5 2021 In particular, ALA is able to reduce inflammasome activity, the pro-inflammatory cytokine levels, such as TNF-alpha, IL-1beta, IL-6, IL-18 and IL-17, interferon (INF)-gamma as well as the production of Vascular and Intercellular cell adhesion protein (VCAM-1 and ICAM-1). Thioctic Acid 15-18 interferon gamma Homo sapiens 150-172 34937023-0 2021 Crosslinked layered surfaces of heparin and poly(L-lysine) enhance mesenchymal stromal cells behavior in the presence of soluble interferon gamma. Heparin 32-39 interferon gamma Homo sapiens 129-145 34744115-5 2021 When ISP-GAS was introduced into four cell lines and subjected to IFN-gamma stimulation, dose-dependency was observed with an EC50 ranging from 0.2 to 0.9 ng/mL, indicating that ISP-GAS can be generally used as a sensitive biosensor of IFN-gamma response. isp 5-8 interferon gamma Homo sapiens 66-75 34744115-5 2021 When ISP-GAS was introduced into four cell lines and subjected to IFN-gamma stimulation, dose-dependency was observed with an EC50 ranging from 0.2 to 0.9 ng/mL, indicating that ISP-GAS can be generally used as a sensitive biosensor of IFN-gamma response. isp 5-8 interferon gamma Homo sapiens 236-245 34937023-3 2021 The aim of this study is to evaluate multilayers of heparin and poly(L-lysine) (HEP/PLL) as a bioactive surface for hMSCs stimulated with soluble interferon gamma (IFN-gamma). Heparin 52-59 interferon gamma Homo sapiens 146-173 34937023-3 2021 The aim of this study is to evaluate multilayers of heparin and poly(L-lysine) (HEP/PLL) as a bioactive surface for hMSCs stimulated with soluble interferon gamma (IFN-gamma). poly(l-lysine) 64-78 interferon gamma Homo sapiens 146-173 34937023-10 2021 Lastly, hMSCs cultured on crosslinked (HEP/PLL) multilayers in the presence of soluble IFN- gamma successfully differentiated towards the osteogenic and adipogenic lineages as confirmed by Alizarin red, and oil-red O staining, as well as alkaline phosphatase activity. alizarin 189-201 interferon gamma Homo sapiens 87-97 34937023-10 2021 Lastly, hMSCs cultured on crosslinked (HEP/PLL) multilayers in the presence of soluble IFN- gamma successfully differentiated towards the osteogenic and adipogenic lineages as confirmed by Alizarin red, and oil-red O staining, as well as alkaline phosphatase activity. oil red O 207-216 interferon gamma Homo sapiens 87-97 34756079-12 2021 It has been suggested that by using the QuantiFERON-TB gold plus, an interferon gamma (IFN-gamma) release assay, a difference in IFN-gamma production between the two antigen tubes (TB2 minus TB1) of >0.6 IU ml-1 could serve as a proxy marker for recent infection. tb gold 52-59 interferon gamma Homo sapiens 129-138 34907183-3 2021 C-aAbs against IL-1alpha, IL-6, IL-10, IFNalpha, IFNgamma and GM-CSF were measured in 131 HSCT recipients before and after (days + 7, + 14, + 28) HSCT and tested for associations with 33 different plasma biomarkers, leukocyte subsets, platelets and clinical outcomes, including engraftment, GvHD and infections. c-aabs 0-6 interferon gamma Homo sapiens 49-57 34988139-10 2021 In addition, SGDL granule + doxycycline effectively inhibited IBV replication and stopped IBV propagation from the trachea to the lung; modulated the mRNA expressions of IL-1beta, IL-6, TNF-alpha, and IFN-gamma; and extenuated the histopathology lesions in trachea and lung. Doxycycline 28-39 interferon gamma Homo sapiens 201-210 34970256-0 2021 Treatment With Cladribine Selects IFNgamma+IL17+ T Cells in RRMS Patients - An In Vitro Study. Cladribine 15-25 interferon gamma Homo sapiens 34-42 34904269-3 2022 This study was conducted to evaluate the expression of selected cytokine (IL1B, IL2, IL6, IL10, TNF, TGFB1, IFNG) and Toll-like receptor (TLR2) genes in lymphocytes isolated from whole human blood infected with S. aureus Newman strain treated with TA. anethole 248-250 interferon gamma Homo sapiens 108-112 34895310-8 2021 Although all JAKi, blocked IFN-gamma-induced JAK1.2/STAT1 phosphorylation at higher concentrations (100 nM), baricitinib most efficiently inhibited IFN-gamma-induced JAK1.2/STAT1 phosphorylation at lower concentrations (<= 25 nM). baricitinib 109-120 interferon gamma Homo sapiens 148-157 34895310-9 2021 Among these JAKi, baricitinib was the most potent regulator for IFN-gamma-induced IL-6 production in human neutrophils. baricitinib 18-29 interferon gamma Homo sapiens 64-73 34890370-8 2021 In obese women, the levels of CRP positively correlated with Zn, TNFalpha with Mg, IFNgamma with Cu and P. Copper 97-99 interferon gamma Homo sapiens 83-91 34767749-5 2021 Functionally, IFN-gamma-treated CMs exhibited a more matured electrophysiological profile, such as increased calcium dynamics and action potential upstroke velocity, demonstrated through calcium imaging and MEA. Calcium 109-116 interferon gamma Homo sapiens 14-23 34956168-0 2021 Screening for Active Compounds Targeting Human Natural Killer Cell Activation Identifying Daphnetin as an Enhancer for IFN-gamma Production and Direct Cytotoxicity. daphnetin 90-99 interferon gamma Homo sapiens 119-128 34767749-5 2021 Functionally, IFN-gamma-treated CMs exhibited a more matured electrophysiological profile, such as increased calcium dynamics and action potential upstroke velocity, demonstrated through calcium imaging and MEA. Calcium 187-194 interferon gamma Homo sapiens 14-23 34893694-6 2021 CECs differentiated from peripheral blood mononuclear cells potently suppress T-cell activation, proliferation, and IFN-gamma production in an ARG- and ROS-dependent manner. Arginine 143-146 interferon gamma Homo sapiens 116-125 34893694-6 2021 CECs differentiated from peripheral blood mononuclear cells potently suppress T-cell activation, proliferation, and IFN-gamma production in an ARG- and ROS-dependent manner. Reactive Oxygen Species 152-155 interferon gamma Homo sapiens 116-125 34956168-4 2021 We found that five compounds, namely, Daphnetin, MK-8617, LW6, JIB-04, and IOX1, increased the IFN-gamma+ NK cell ratio in the presence of IL-12. daphnetin 38-47 interferon gamma Homo sapiens 95-104 34904674-1 2021 AIM: To analyze the agreement between tuberculin skin test (TST) and fourth-generation QuantiFERON (QFT)-TB Gold Plus (interferon gamma (INF-gamma) release assays (IGRA)) for latent tuberculosis infection (LTBI) diagnosis among under-five children who are undernourished and/or who have history of contact with active tuberculosis (TB) patients. tb gold 105-112 interferon gamma Homo sapiens 119-146 34956168-4 2021 We found that five compounds, namely, Daphnetin, MK-8617, LW6, JIB-04, and IOX1, increased the IFN-gamma+ NK cell ratio in the presence of IL-12. N-(bis(4-methoxyphenyl)methyl)-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide 49-56 interferon gamma Homo sapiens 95-104 34956168-5 2021 Further studies using purified human primary NK cells revealed that Daphnetin directly promoted NK cell IFN-gamma production in the presence of IL-12 but not IL-15, while the other four compounds acted on NK cells indirectly. daphnetin 68-77 interferon gamma Homo sapiens 104-113 34959939-0 2021 Inhibitory Effects of Luteolin 7-Methyl Ether Isolated from Wikstroemia ganpi on Tnf-A/Ifn-Gamma Mixture-Induced Inflammation in Human Keratinocyte. hydroxygenkwanin 22-45 interferon gamma Homo sapiens 87-96 34956168-8 2021 This was further confirmed by the finding that both inhibitors of PI3K-Akt and its main downstream signaling mTOR, LY294002, and rapamycin, respectively, can reverse the increase of IFN-gamma production and cytotoxicity in NK cells promoted by Daphnetin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 115-123 interferon gamma Homo sapiens 182-191 34956168-8 2021 This was further confirmed by the finding that both inhibitors of PI3K-Akt and its main downstream signaling mTOR, LY294002, and rapamycin, respectively, can reverse the increase of IFN-gamma production and cytotoxicity in NK cells promoted by Daphnetin. Sirolimus 129-138 interferon gamma Homo sapiens 182-191 34956168-8 2021 This was further confirmed by the finding that both inhibitors of PI3K-Akt and its main downstream signaling mTOR, LY294002, and rapamycin, respectively, can reverse the increase of IFN-gamma production and cytotoxicity in NK cells promoted by Daphnetin. daphnetin 244-253 interferon gamma Homo sapiens 182-191 34741187-5 2021 ERK1/2 activated by the combined action of RBD and cytokines crucial for the development of severe COVID-19, i.e. interferon-gamma (IFNgamma) and tumour necrosis factor-alpha (TNFalpha), are more effectively inactivated by CO2 than by dexamethasone or acetylsalicylic acid in human bronchial epithelial cells. Carbon Dioxide 223-226 interferon gamma Homo sapiens 114-130 34878724-11 2022 In addition, increases in the lymphoproliferative activity of re-stimulated splenic lymphocytes, interfron-gamma (IFN-gamma) and interleukin-2 (IL-2) concentration in the irradiated AIV-IO-CMC group demonstrated the activation of Type 1 helper cells. cmc 189-192 interferon gamma Homo sapiens 114-123 34899969-0 2021 N-Acetylcysteine (NAC) Inhibits Synthesis of IL-18 in Macrophage by Suppressing NLRP3 Expression to Reduce the Production of IFN-gamma from NK Cells. Acetylcysteine 0-16 interferon gamma Homo sapiens 125-134 34899969-0 2021 N-Acetylcysteine (NAC) Inhibits Synthesis of IL-18 in Macrophage by Suppressing NLRP3 Expression to Reduce the Production of IFN-gamma from NK Cells. Acetylcysteine 18-21 interferon gamma Homo sapiens 125-134 34899969-11 2021 Conclusion: NAC could effectively inhibit the production of IL-18 by suppressing NLRP3 expression in macrophages to reduce the production of IFN-gamma in NK cells. Acetylcysteine 12-15 interferon gamma Homo sapiens 141-150 34851565-12 2021 Auraptene effect the gene expression of important gene related to angiogenesis (VEGF, VEGFR2, COX2, IFNgamma). aurapten 0-9 interferon gamma Homo sapiens 100-108 34851565-14 2021 CONCLUSIONS: Overall, this study shows that Auraptene significantly suppressed angiogenesis via down-regulation of VEGF, VEGFR2, VCAM-1, TNFR-1, COX-2 and up-regulation of IFNgamma. aurapten 44-53 interferon gamma Homo sapiens 172-180 34546851-7 2021 Calcitriol repressed the release of inflammation-related cytokines, such as interleukin-5 (IL-5), interleukin-13 (IL-13), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha). Calcitriol 0-10 interferon gamma Homo sapiens 122-138 34546851-7 2021 Calcitriol repressed the release of inflammation-related cytokines, such as interleukin-5 (IL-5), interleukin-13 (IL-13), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha). Calcitriol 0-10 interferon gamma Homo sapiens 140-149 34656059-7 2021 Treatment with AOWex inhibited the expression of proinflammatory chemokines such as MDC, RANTES, IP-10 and I-TAC in interferon-gamma and tumor necrosis factor-alpha-stimulated HaCaT cells. aowex 15-20 interferon gamma Homo sapiens 116-164 34668346-11 2021 Res suppressed Cd-induced apoptosis in placenta and JEG-3 cells, and decreased Cd-induced expression of TNF-alpha, IFN-gamma, MCP-1, MIP-2, and KC in placenta. Cadmium 79-81 interferon gamma Homo sapiens 115-124 34705053-6 2021 Distinctly, in RA FLS, 2-DG and IACS therapies constrained LPS/IFNgamma-induced AKT and JNK signaling, IRF5/7 and fibrokine expression. Deoxyglucose 23-27 interferon gamma Homo sapiens 63-71 34741187-5 2021 ERK1/2 activated by the combined action of RBD and cytokines crucial for the development of severe COVID-19, i.e. interferon-gamma (IFNgamma) and tumour necrosis factor-alpha (TNFalpha), are more effectively inactivated by CO2 than by dexamethasone or acetylsalicylic acid in human bronchial epithelial cells. Carbon Dioxide 223-226 interferon gamma Homo sapiens 132-140 34363189-7 2021 Clarithromycin use was associated with decreases in circulating C-reactive protein, tumour necrosis factor-alpha and interleukin (IL)-6; by increase of production of interferon-gamma and decrease of production of interleukin-6 by mononuclear cells; and by suppression of SARS-CoV-2 viral load. Clarithromycin 0-14 interferon gamma Homo sapiens 166-182 34402750-7 2021 Linear regression analysis revealed that among a broad range of cytokines and chemokines analyzed, IFN-gamma levels are positively associated with estradiol levels in male and female COVID-19 patients. Estradiol 147-156 interferon gamma Homo sapiens 99-108 34887262-11 2021 SN-38 or metformin sensitized unresponsive tumors responding to anti-PD-1 therapy by engaging NK or CD8+ T cells to infiltrate the tumor microenvironment (TME) and secret interferon-gamma and granzyme B to kill tumors. Irinotecan 0-5 interferon gamma Homo sapiens 171-187 34626802-5 2021 The IFNgamma-induced IL-8 expression is dependent on JAK1, STAT1, and p65 NFkappaB, and is associated with an increased occupancy of K314/315 acetylated p65 NFkappaB and Ser-727 phosphorylated STAT1 at the IL-8 promoter. Serine 170-173 interferon gamma Homo sapiens 4-12 34887262-11 2021 SN-38 or metformin sensitized unresponsive tumors responding to anti-PD-1 therapy by engaging NK or CD8+ T cells to infiltrate the tumor microenvironment (TME) and secret interferon-gamma and granzyme B to kill tumors. Metformin 9-18 interferon gamma Homo sapiens 171-187 34757416-12 2021 In 1 patient with a robust improvement following treatment with tofacitinib, RNA sequencing identified interferon gamma (IFN-gamma) and interleukin 15 (IL-15) as cytokines with activity both highly upregulated at baseline in lesional skin and subsequently suppressed following tofacitinib treatment. tofacitinib 64-75 interferon gamma Homo sapiens 103-130 34662550-0 2021 The pro-proliferative effect of interferon-gamma in breast cancer cell lines is dependent on stimulation of ASCT2-mediated glutamine cellular uptake. Glutamine 123-132 interferon gamma Homo sapiens 32-48 34662550-6 2021 IFN-gamma increased total and Na+-dependent 3H-GLN uptake in the two breast cancer cell lines, and insulin increased total and Na+-dependent 3H-GLN uptake in the non-tumorigenic cell line. 3h-gln 44-50 interferon gamma Homo sapiens 0-9 34662550-8 2021 ASCT2 knockdown confirmed that the increase in 3H-GLN uptake caused by IFN-gamma (in breast cancer cells) and by insulin (in non-tumorigenic cells) is ASCT2-dependent. 3h-gln 47-53 interferon gamma Homo sapiens 71-80 34662550-10 2021 Importantly, the pro-proliferative effect of IFN-gamma in breast cancer cell lines was associated with an increase in 3H-GLN uptake which was GPNA-sensitive, blocked by ASCT2 knockdown and mediated by activation of the PI3K-, STAT3- and STAT1 intracellular signalling pathways. 3h-gln 118-124 interferon gamma Homo sapiens 45-54 34662550-11 2021 SIGNIFICANCE: IFN-gamma and insulin possess pro-proliferative effects in breast cancer and non-cancer cell lines, respectively, which are dependent on an increase in ASCT2-mediated glutamine transport. Glutamine 181-190 interferon gamma Homo sapiens 14-23 34668283-5 2021 With increasing concentrations of tacrolimus, there was a trend to reduction in the release of IL-2 (p = 0.0137), and IFN-gamma (p = 0.0147) in response to peptide stimulation. Tacrolimus 34-44 interferon gamma Homo sapiens 118-127 34541571-31 2021 Tambien hubo un aumento en las celulas T especificas de RBD que producen IFN-gamma y TNF-alpha. tambien 0-7 interferon gamma Homo sapiens 73-82 34390094-4 2021 CMV-Tc was measured by intracellular IFNgamma flow cytometry, when possible, at baseline, 1 month after CMV viremia (>5 copies/PCR) and serially until CMV-Tc was positive (>=0.2%). cmv-tc 0-6 interferon gamma Homo sapiens 37-45 34884740-11 2021 Treatment of MSC with IFNgamma led to a profound effect on the protein make up of EV and MP, demonstrating the possibility to modify the phenotype of EV and MP through modification of parent MSC. mp 89-91 interferon gamma Homo sapiens 22-30 34884740-11 2021 Treatment of MSC with IFNgamma led to a profound effect on the protein make up of EV and MP, demonstrating the possibility to modify the phenotype of EV and MP through modification of parent MSC. mp 157-159 interferon gamma Homo sapiens 22-30 34850023-6 2022 In comparison to controls, patients with CPA had significantly reduced production of IFNgamma in response to stimulation with beta-glucan+IL-12 (312 vs 988 pg/ml), LPS+IL-12 (252 vs 1033 pg/ml), ZYM+IL-12 (996 vs 2347 pg/ml), and IL-18+IL-12 (7193 vs 12330 pg/ml). cpa 41-44 interferon gamma Homo sapiens 85-93 34850023-6 2022 In comparison to controls, patients with CPA had significantly reduced production of IFNgamma in response to stimulation with beta-glucan+IL-12 (312 vs 988 pg/ml), LPS+IL-12 (252 vs 1033 pg/ml), ZYM+IL-12 (996 vs 2347 pg/ml), and IL-18+IL-12 (7193 vs 12330 pg/ml). beta-Glucans 126-137 interferon gamma Homo sapiens 85-93 34850240-8 2022 A core secretory effector molecule profile (IFN-gamma, IL-13, granzyme B and perforin) was identified for sulfapyridine and sulfapyridine hydroxylamine responsive T-cell clones, which proceeded through Pi and hapten mechanisms, respectively. Sulfapyridine 106-119 interferon gamma Homo sapiens 44-53 34850023-7 2022 Age >60 (p=0.05, HR 1.71, 95%CI 1.00-2.91) and COPD (p=0.039, HR 1.69, 95%CI 1.03-2.78) were associated with worse survival, whereas high IFNgamma production in response to beta-glucan+IL-12 stimulation (p=0.026, HR 0.48, 95%CI 0.25-0.92) was associated with reduced mortality. beta-Glucans 173-184 interferon gamma Homo sapiens 138-146 34850023-8 2022 CONCLUSION: Patients with CPA show impaired IFNgamma production in peripheral blood in response to stimuli. cpa 26-29 interferon gamma Homo sapiens 44-52 34850023-10 2022 Immunotherapy with IFNgamma could be beneficial for patients showing impaired IFNgamma production in CPA. cpa 101-104 interferon gamma Homo sapiens 19-27 34850023-10 2022 Immunotherapy with IFNgamma could be beneficial for patients showing impaired IFNgamma production in CPA. cpa 101-104 interferon gamma Homo sapiens 78-86 34850240-8 2022 A core secretory effector molecule profile (IFN-gamma, IL-13, granzyme B and perforin) was identified for sulfapyridine and sulfapyridine hydroxylamine responsive T-cell clones, which proceeded through Pi and hapten mechanisms, respectively. sulfapyridine hydroxylamine 124-151 interferon gamma Homo sapiens 44-53 34899697-0 2021 Tetracyclines Diminish In Vitro IFN-gamma and IL-17-Producing Adaptive and Innate Immune Cells in Multiple Sclerosis. Tetracyclines 0-13 interferon gamma Homo sapiens 32-41 34899697-6 2021 Results: Both tetracyclines significantly decreased, in a dose dependent manner, IFN-gamma production in NKT and CD4+ T lymphocytes from MS patients (naive or treated) stimulated with IL-12/IL-18 but did not decrease IFN-gamma producing CD8+ T cells from naive MS or treated RRMS patients. Tetracyclines 14-27 interferon gamma Homo sapiens 81-90 34899697-9 2021 Conclusion: Tetracyclines can in vitro suppress IFN-gamma and IL-17- producing cells from MS patients, and this may explain their potential therapeutic effect in vivo. Tetracyclines 12-25 interferon gamma Homo sapiens 48-57 34825313-0 2022 Delphinidin diminishes in vitro interferon-gamma and interleukin-17 producing cells in patients with psoriatic disease. delphinidin 0-11 interferon gamma Homo sapiens 32-48 34843983-0 2022 Vesicular IFN-gamma as a cooperative attacker to enhance anti-cancer effect of 5-fluorouracil via thymidine phosphorylase upregulation and tumor microenvironment normalization. Fluorouracil 79-93 interferon gamma Homo sapiens 10-19 34843983-1 2022 On the basis of immuno-modulating effect and upregulating the activity of thymidine phosphorylase (TP), interferon-gamma (IFN-gamma) as a cooperative attacker was explored to enhance the anticancer activity of 5-FU. Fluorouracil 210-214 interferon gamma Homo sapiens 104-120 34843983-1 2022 On the basis of immuno-modulating effect and upregulating the activity of thymidine phosphorylase (TP), interferon-gamma (IFN-gamma) as a cooperative attacker was explored to enhance the anticancer activity of 5-FU. Fluorouracil 210-214 interferon gamma Homo sapiens 122-131 34843983-2 2022 We designed and prepared a self-assembled nano-vesicular system IFN-gamma-EDP formulated by amphiphilic poly((polyethylene glycol)(dodecylphospho-ethanolamine)phosphazene) (EDP) to entrap IFN-gamma in the hydrophilic cavity. poly((polyethylene glycol)(dodecylphospho-ethanolamine)phosphazene 104-170 interferon gamma Homo sapiens 64-73 34843983-2 2022 We designed and prepared a self-assembled nano-vesicular system IFN-gamma-EDP formulated by amphiphilic poly((polyethylene glycol)(dodecylphospho-ethanolamine)phosphazene) (EDP) to entrap IFN-gamma in the hydrophilic cavity. poly((polyethylene glycol)(dodecylphospho-ethanolamine)phosphazene 104-170 interferon gamma Homo sapiens 188-197 34843983-2 2022 We designed and prepared a self-assembled nano-vesicular system IFN-gamma-EDP formulated by amphiphilic poly((polyethylene glycol)(dodecylphospho-ethanolamine)phosphazene) (EDP) to entrap IFN-gamma in the hydrophilic cavity. 2-ethyl-3,5-dimethylpyrazine 173-176 interferon gamma Homo sapiens 64-73 34843983-2 2022 We designed and prepared a self-assembled nano-vesicular system IFN-gamma-EDP formulated by amphiphilic poly((polyethylene glycol)(dodecylphospho-ethanolamine)phosphazene) (EDP) to entrap IFN-gamma in the hydrophilic cavity. 2-ethyl-3,5-dimethylpyrazine 173-176 interferon gamma Homo sapiens 188-197 34843983-3 2022 The IFN-gamma-EDP vesicles allowed IFN-gamma to accumulate at the tumor site and be taken up by tumor cells, resulting in significantly upregulated expression level of TP, distinct inhibition of cell growth, more cellular apoptosis and more serious cell cycle arrest when administrated combined with 5-FU. Fluorouracil 300-304 interferon gamma Homo sapiens 4-13 34843983-3 2022 The IFN-gamma-EDP vesicles allowed IFN-gamma to accumulate at the tumor site and be taken up by tumor cells, resulting in significantly upregulated expression level of TP, distinct inhibition of cell growth, more cellular apoptosis and more serious cell cycle arrest when administrated combined with 5-FU. Fluorouracil 300-304 interferon gamma Homo sapiens 35-44 34843983-5 2022 As a consequence, the combination therapy of IFN-gamma-EDP with 5-FU achieved remarkably enhanced tumor inhibition rate of 56.9% against CT26 colorectal cancer. Fluorouracil 64-68 interferon gamma Homo sapiens 45-54 34825313-6 2022 Delphinidin dose-dependently reduced IFNgamma+ T cells from patients and HCs. delphinidin 0-11 interferon gamma Homo sapiens 37-45 34825313-9 2022 An inhibitory effect of delphinidin was also noted in IFNgamma producing NKs and NKTs from psoriasis individuals. delphinidin 24-35 interferon gamma Homo sapiens 54-62 34825313-11 2022 In conclusion, delphinidin exerts a profound in vitro anti-inflammatory effect in psoriasis and psoriatic arthritis by inhibiting IFNgamma+ innate and adaptive cells and T helper (Th) 17 cells. delphinidin 15-26 interferon gamma Homo sapiens 130-138 34802039-10 2021 There was a significantly positive correlation between IDO levels and the PANSS negative scores and between IDO levels and TNF-alpha and IFN-gamma levels in the celecoxib group. Celecoxib 161-170 interferon gamma Homo sapiens 137-146 34813381-5 2022 RESULTS: MC signatures except unstimulated, repeated FcepsilonR1-stimulated and IFNgamma-stimulated were enriched in SA. sa 117-119 interferon gamma Homo sapiens 80-88 34899707-7 2021 Among the 113 predicted drugs, melatonin (MLT) was co-associated with both RORA and IFN-gamma in AD and rosacea. Melatonin 31-40 interferon gamma Homo sapiens 84-93 34880863-8 2021 The 4 most promising peptides were synthesized, and the peptides with and without incorporation into glucan particles induced CD4+ and CD8+ T cell proliferation and produced a Th1 and Th17 response marked by the secretion of high levels of IFN-gamma, IL-17 and IL-2. Glucans 101-107 interferon gamma Homo sapiens 240-249 34636650-0 2021 Interferon-gamma Impairs Human Coronary Artery Endothelial Glucose Metabolism via Tryptophan Catabolism and Activates Fatty Acid Oxidation. Fatty Acids 118-128 interferon gamma Homo sapiens 0-16 34868078-4 2021 In the treatment of vitiligo, JAK inhibitors, including ruxolitinib, baricitinib, and tofacitinib, are effective, supporting the implication of the IFN-gamma-chemokine signaling axis in the pathogenesis of vitiligo. ruxolitinib 56-67 interferon gamma Homo sapiens 148-157 34868078-4 2021 In the treatment of vitiligo, JAK inhibitors, including ruxolitinib, baricitinib, and tofacitinib, are effective, supporting the implication of the IFN-gamma-chemokine signaling axis in the pathogenesis of vitiligo. baricitinib 69-80 interferon gamma Homo sapiens 148-157 34868078-4 2021 In the treatment of vitiligo, JAK inhibitors, including ruxolitinib, baricitinib, and tofacitinib, are effective, supporting the implication of the IFN-gamma-chemokine signaling axis in the pathogenesis of vitiligo. tofacitinib 86-97 interferon gamma Homo sapiens 148-157 34785653-7 2021 Mechanistically, TKIs augmented the efflux of isopentenyl pyrophosphate (IPP) from CML cells, which stimulated IFN-gamma production and gammadeltaT expansion. isopentenyl pyrophosphate 46-71 interferon gamma Homo sapiens 111-120 34785653-7 2021 Mechanistically, TKIs augmented the efflux of isopentenyl pyrophosphate (IPP) from CML cells, which stimulated IFN-gamma production and gammadeltaT expansion. isopentenyl pyrophosphate 73-76 interferon gamma Homo sapiens 111-120 34785653-8 2021 Notably, the size of the IFN-gamma+ naive gammadeltaT population in TKI-treated CML patients was strongly correlated with their rates to reach DMR and with the duration on DMR. aspartylmethionylarginine 143-146 interferon gamma Homo sapiens 25-34 34785653-8 2021 Notably, the size of the IFN-gamma+ naive gammadeltaT population in TKI-treated CML patients was strongly correlated with their rates to reach DMR and with the duration on DMR. aspartylmethionylarginine 172-175 interferon gamma Homo sapiens 25-34 34636650-9 2021 The decrease in HIF1alpha activity was a consequence of IFN-gamma-induced tryptophan catabolism resulting in ARNT (aryl hydrocarbon receptor nuclear translocator)/HIF1beta sequestration by the kynurenine-activated aryl hydrocarbon receptor (AHR). Tryptophan 74-84 interferon gamma Homo sapiens 56-65 34636650-10 2021 Additionally, IFN-gamma resulted in a 23% depletion of intracellular NAD+ in HCAEC. NAD 69-73 interferon gamma Homo sapiens 14-23 34636650-13 2021 Conclusions: IFN-gamma impairs endothelial glucose metabolism via altered tryptophan catabolism destabilizing HIF1, depletes NAD+, and results in a metabolic shift toward increased fatty acid oxidation. NAD 125-129 interferon gamma Homo sapiens 13-22 34636650-13 2021 Conclusions: IFN-gamma impairs endothelial glucose metabolism via altered tryptophan catabolism destabilizing HIF1, depletes NAD+, and results in a metabolic shift toward increased fatty acid oxidation. Fatty Acids 181-191 interferon gamma Homo sapiens 13-22 34636650-14 2021 This work suggests a novel mechanistic basis for pathologic T-lymphocyte-endothelial interactions in atherosclerosis mediated by IFN-gamma, linking endothelial glucose, tryptophan, and fatty acid metabolism with NAD(H) and ATP generation, and their adverse endothelial functional consequences. Glucose 160-167 interferon gamma Homo sapiens 129-138 34636650-14 2021 This work suggests a novel mechanistic basis for pathologic T-lymphocyte-endothelial interactions in atherosclerosis mediated by IFN-gamma, linking endothelial glucose, tryptophan, and fatty acid metabolism with NAD(H) and ATP generation, and their adverse endothelial functional consequences. Tryptophan 169-179 interferon gamma Homo sapiens 129-138 34636650-14 2021 This work suggests a novel mechanistic basis for pathologic T-lymphocyte-endothelial interactions in atherosclerosis mediated by IFN-gamma, linking endothelial glucose, tryptophan, and fatty acid metabolism with NAD(H) and ATP generation, and their adverse endothelial functional consequences. Fatty Acids 185-195 interferon gamma Homo sapiens 129-138 34636650-14 2021 This work suggests a novel mechanistic basis for pathologic T-lymphocyte-endothelial interactions in atherosclerosis mediated by IFN-gamma, linking endothelial glucose, tryptophan, and fatty acid metabolism with NAD(H) and ATP generation, and their adverse endothelial functional consequences. NAD 212-218 interferon gamma Homo sapiens 129-138 34868950-9 2021 Interferon-gamma increased postoperatively in the dexmedetomidine group, whereas it maintained at the baseline value in the control group. Dexmedetomidine 50-65 interferon gamma Homo sapiens 0-16 34636650-14 2021 This work suggests a novel mechanistic basis for pathologic T-lymphocyte-endothelial interactions in atherosclerosis mediated by IFN-gamma, linking endothelial glucose, tryptophan, and fatty acid metabolism with NAD(H) and ATP generation, and their adverse endothelial functional consequences. Adenosine Triphosphate 223-226 interferon gamma Homo sapiens 129-138 34836309-0 2021 Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1. Vitamin D 20-29 interferon gamma Homo sapiens 148-152 34868950-14 2021 Conclusions: Perioperative dexmedetomidine had no favorable impacts on NK cell activity, inflammatory responses, or prognosis, whereas it increased interferon-gamma and reduced early postoperative pain severity and opioid consumption in uterine cancer surgery patients. Dexmedetomidine 27-42 interferon gamma Homo sapiens 148-164 34836309-9 2021 The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1. 25ohd 59-64 interferon gamma Homo sapiens 154-158 34836309-9 2021 The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1. Vitamin D 84-93 interferon gamma Homo sapiens 154-158 34867992-10 2021 Proteomic and gene expression analyses revealed that IFN-gamma/TNF-alpha-treated cells corroborate mitochondrial dysfunction, transmembrane potential of mitochondria, altered fatty acid metabolism and cardiac necrosis/cell death. Fatty Acids 175-185 interferon gamma Homo sapiens 53-62 34909043-7 2022 The supernatant of DCs pulsed with HOCl preparation showed significantly higher levels of interferon gamma and lower levels of IL-10 compared with the other groups. Hypochlorous Acid 35-39 interferon gamma Homo sapiens 90-106 34774955-6 2022 Correlation analysis indicated that RAS Guanyl Releasing Protein 2 (RASGRP2) and Phospholipase A2 Group IVE (PLA2G4E) were positively associated with the increased serotonin which was positively associated with the stimulated IFN-gamma in BPF-treated NCM460 cells. Serotonin 164-173 interferon gamma Homo sapiens 226-235 34774955-6 2022 Correlation analysis indicated that RAS Guanyl Releasing Protein 2 (RASGRP2) and Phospholipase A2 Group IVE (PLA2G4E) were positively associated with the increased serotonin which was positively associated with the stimulated IFN-gamma in BPF-treated NCM460 cells. bisphenol F 239-242 interferon gamma Homo sapiens 226-235 34867961-9 2021 In stimulating peripheral blood mononuclear cells using PMA plus ionomycin, a high TIM3 level on T cells correlated with low interleukin-2 and tumor necrosis factor-alpha (TNF-alpha) on CD4+ cells and interferon-gamma and TNF-alpha on CD8+ T cells. Tetradecanoylphorbol Acetate 56-59 interferon gamma Homo sapiens 201-217 34867961-9 2021 In stimulating peripheral blood mononuclear cells using PMA plus ionomycin, a high TIM3 level on T cells correlated with low interleukin-2 and tumor necrosis factor-alpha (TNF-alpha) on CD4+ cells and interferon-gamma and TNF-alpha on CD8+ T cells. Ionomycin 65-74 interferon gamma Homo sapiens 201-217 34804038-7 2021 However, EBV exposure impaired the cytokine (IFN-gamma, IL-2, and TNF-alpha) secretion capability of CD4+ and CD8+ T cells after stimulation with PMA/ionomycin in vitro. Tetradecanoylphorbol Acetate 146-149 interferon gamma Homo sapiens 45-54 34819931-5 2021 Tryptophan metabolite concentrations in the Chlamydia-infected and/or interferon-gamma (IFNG)-treated neutrophils were measured by ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Tryptophan 0-10 interferon gamma Homo sapiens 88-92 34819931-9 2021 The tryptophan-degrading activity of IDO1 was not induced significantly by Chlamydia infection alone, but the addition of IFNG greatly increased its activity. Tryptophan 4-14 interferon gamma Homo sapiens 122-126 34741776-4 2022 IFN-gamma induced human retinal pigment epithelial cell (ARPE-19) death accompanied by increases in Fe2+ , reactive oxygen species, lipid peroxidation, and glutathione (GSH) depletion, which are main characteristics of ferroptosis. ammonium ferrous sulfate 100-104 interferon gamma Homo sapiens 0-9 34741776-4 2022 IFN-gamma induced human retinal pigment epithelial cell (ARPE-19) death accompanied by increases in Fe2+ , reactive oxygen species, lipid peroxidation, and glutathione (GSH) depletion, which are main characteristics of ferroptosis. Reactive Oxygen Species 107-130 interferon gamma Homo sapiens 0-9 34741776-4 2022 IFN-gamma induced human retinal pigment epithelial cell (ARPE-19) death accompanied by increases in Fe2+ , reactive oxygen species, lipid peroxidation, and glutathione (GSH) depletion, which are main characteristics of ferroptosis. Glutathione 156-167 interferon gamma Homo sapiens 0-9 34741776-4 2022 IFN-gamma induced human retinal pigment epithelial cell (ARPE-19) death accompanied by increases in Fe2+ , reactive oxygen species, lipid peroxidation, and glutathione (GSH) depletion, which are main characteristics of ferroptosis. Glutathione 169-172 interferon gamma Homo sapiens 0-9 34741776-5 2022 Mechanistically, IFN-gamma upregulates the level of intracellular Fe2+ through inhibiting Fe2+ efflux protein SLC40A1 and induces GSH depletion by blocking cystine/glutamate antiporter, System xc-. ammonium ferrous sulfate 66-70 interferon gamma Homo sapiens 17-26 34741776-5 2022 Mechanistically, IFN-gamma upregulates the level of intracellular Fe2+ through inhibiting Fe2+ efflux protein SLC40A1 and induces GSH depletion by blocking cystine/glutamate antiporter, System xc-. ammonium ferrous sulfate 90-94 interferon gamma Homo sapiens 17-26 34741776-5 2022 Mechanistically, IFN-gamma upregulates the level of intracellular Fe2+ through inhibiting Fe2+ efflux protein SLC40A1 and induces GSH depletion by blocking cystine/glutamate antiporter, System xc-. Glutathione 130-133 interferon gamma Homo sapiens 17-26 34741776-5 2022 Mechanistically, IFN-gamma upregulates the level of intracellular Fe2+ through inhibiting Fe2+ efflux protein SLC40A1 and induces GSH depletion by blocking cystine/glutamate antiporter, System xc-. Cystine 156-163 interferon gamma Homo sapiens 17-26 34741776-5 2022 Mechanistically, IFN-gamma upregulates the level of intracellular Fe2+ through inhibiting Fe2+ efflux protein SLC40A1 and induces GSH depletion by blocking cystine/glutamate antiporter, System xc-. Glutamic Acid 164-173 interferon gamma Homo sapiens 17-26 34741776-7 2022 JAK1/2 and STAT1 inhibitors could reverse the reduction of SLC7A11, GPx4 and GSH expression induced by IFN-gamma, indicating IFN-gamma induces ARPE-19 cell ferroptosis via activation of the JAK1-2/STAT1/SLC7A11 signaling pathway. Glutathione 77-80 interferon gamma Homo sapiens 103-112 34741776-7 2022 JAK1/2 and STAT1 inhibitors could reverse the reduction of SLC7A11, GPx4 and GSH expression induced by IFN-gamma, indicating IFN-gamma induces ARPE-19 cell ferroptosis via activation of the JAK1-2/STAT1/SLC7A11 signaling pathway. Glutathione 77-80 interferon gamma Homo sapiens 125-134 34805266-10 2021 PD-L1 upregulation by glutamine deprivation in bladder cancer cells could reduce IFN-gamma production by T cells. Glutamine 22-31 interferon gamma Homo sapiens 81-90 34804038-7 2021 However, EBV exposure impaired the cytokine (IFN-gamma, IL-2, and TNF-alpha) secretion capability of CD4+ and CD8+ T cells after stimulation with PMA/ionomycin in vitro. Ionomycin 150-159 interferon gamma Homo sapiens 45-54 34734507-9 2021 Alpha-galactosylceramide supplementation significantly increased the frequencies of drug-induced IFN-gamma releasing cells. alpha-galactosylceramide 0-24 interferon gamma Homo sapiens 97-106 34834279-3 2021 Here we aimed to analyse the structural properties of water in a sample of an aqueous solution of IFNgamma via terahertz time-domain spectroscopy (THz-TDS). Water 54-59 interferon gamma Homo sapiens 98-106 34834279-3 2021 Here we aimed to analyse the structural properties of water in a sample of an aqueous solution of IFNgamma via terahertz time-domain spectroscopy (THz-TDS). thz 147-150 interferon gamma Homo sapiens 98-106 34834279-6 2021 Lactose saturated with dilutions of antibodies to IFNgamma (incubated for more than 2.5 h) changed the structural properties of an IFNgamma aqueous solution without direct contact compared to the control. Lactose 0-7 interferon gamma Homo sapiens 50-58 34834279-6 2021 Lactose saturated with dilutions of antibodies to IFNgamma (incubated for more than 2.5 h) changed the structural properties of an IFNgamma aqueous solution without direct contact compared to the control. Lactose 0-7 interferon gamma Homo sapiens 131-139 34585422-9 2021 In contrast, EtOH"s inhibition of SAA1-induced inflammatory cytokines (IL-6, IFN-gamma) and reactive oxygen species (ROS) was Notch-independent, as these effects were unaffected by DAPT or by N1 and/or N4 knockdown. Ethanol 13-17 interferon gamma Homo sapiens 77-86 34605616-8 2021 The cytokine profiles showed IL-2, IL-5, IFN-gamma increased; other cytokines including IL-6, IL-10, TNF- alpha and TNF- beta decreased with lenvatinib therapy. lenvatinib 141-151 interferon gamma Homo sapiens 41-50 34390807-4 2021 The two mutants displayed elevated levels of tyrosine phosphorylation, premature nuclear accumulation, and differential transcriptional responses following stimulation of cells with interleukin-6 and interferon-gamma. Tyrosine 45-53 interferon gamma Homo sapiens 200-216 34524494-0 2021 Correction to: IL-15 superagonist N-803 improves IFNgamma production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells. n-803 34-39 interferon gamma Homo sapiens 49-57 34845849-6 2021 After Dara-BCD, these TRM cells were quickly activated with downregulation of suppressive molecules and upregulation of IFNG expression. dara-bcd 6-14 interferon gamma Homo sapiens 120-124 34555645-8 2021 Positive correlation between creatinine with IFN-gamma, CCL-2/MCP-1, and CXCL-10/IP-10, and negative correlation with IL-10 was identified in patients with Kt/V < 1.2 (P < 0.05). Creatinine 29-39 interferon gamma Homo sapiens 45-54 34662469-0 2021 Orthogonal ubiquitin transfer reveals human papillomavirus E6 downregulates nuclear transport to disarm interferon-gamma dependent apoptosis of cervical cancer cells. Fluoxastrobin 97-103 interferon gamma Homo sapiens 104-120 34662469-6 2021 We further found that E6 could significantly reduce the cellular level of KPNA1 that resulted in the suppression of nuclear transport of phosphorylated STAT1 and the inhibition of interferon-gamma-induced apoptosis in cervical cancer cells. Polyurethane Y-290 22-24 interferon gamma Homo sapiens 180-196 34517050-10 2021 Despite adequate CD4 counts, women with HIV express less IFN-gamma than women without HIV , which may explain the high TB incidence in postpartum women with HIV. Terbium 119-121 interferon gamma Homo sapiens 57-66 34551966-8 2021 Our results show that TLR-4-induced IFN-gamma production is regulated by the ribosomal protein S6 kinase (p70S6K) through the activation of PI3K, the mammalian target of rapamycin complex 1/2 (mTORC1/2), and the JNK MAPK pathways. Sirolimus 170-179 interferon gamma Homo sapiens 36-45 34253587-5 2021 Results: DSA-positivity in NR biopsies was associated with mildly increased expression of ABMR-related transcripts, particularly IFNG-inducible and NK cell transcripts. dsa 9-12 interferon gamma Homo sapiens 129-133 34672419-8 2021 T cells treated by 2-DG showed lower LDHA expression and elevated apoptosis, resulting in a reduced apoptotic population of keratinocytes that were co-cultured with them, which was related to the decreased levels of IFN-gamma in co-culture system. Deoxyglucose 19-23 interferon gamma Homo sapiens 216-225 34561230-5 2021 IFN-gamma stimulation conferred on M0 macrophages the sensitivity to SM-induced cell death through the Jak/STAT, IFN regulatory factor-1, and mammalian target of rapamycin complex-1 (mTORC-1)/ribosomal protein S6 kinase pathways. Samarium 69-71 interferon gamma Homo sapiens 0-9 34561230-5 2021 IFN-gamma stimulation conferred on M0 macrophages the sensitivity to SM-induced cell death through the Jak/STAT, IFN regulatory factor-1, and mammalian target of rapamycin complex-1 (mTORC-1)/ribosomal protein S6 kinase pathways. Sirolimus 162-171 interferon gamma Homo sapiens 0-9 34508828-10 2021 Moreover, alpha-tocopherol in the HBsAg vaccine increased IFN-gamma, IL-2, and TNF-alpha cytokines at higher concentrations; however, the vaccine suppressed IL-4 cytokine release. alpha-Tocopherol 10-26 interferon gamma Homo sapiens 58-67 34772757-10 2021 Interferon-gamma was found to empower this AcTakine synergy by sensitizing the tumor microenvironment to TNF. actakine 43-51 interferon gamma Homo sapiens 0-16 34799399-16 2021 NIZ985 treatment was associated with increases in several cytokines, including interferon (IFN)-gamma, IL-18, C-X-C motif chemokine ligand 10, and tumor necrosis factor-beta, plus significant induction of cytotoxic lymphocyte proliferation (including natural killer and CD8+ T cells), increased CD16+ monocytes, and increased CD163+ macrophages at injection sites. niz985 0-6 interferon gamma Homo sapiens 79-101 34799399-17 2021 CONCLUSIONS: Subcutaneous NIZ985 TIW was generally well tolerated in patients with advanced cancer and produced immune activation paralleling preclinical observations, with induction of IFN-gamma and proliferation of cytotoxic lymphocytes. niz985 26-32 interferon gamma Homo sapiens 186-195 34319496-1 2021 Neopterin (NPT) is a member of pteridines group, synthesized by macrophages when stimulated by interferon gamma (INF-gamma). Neopterin 0-9 interferon gamma Homo sapiens 95-122 34319496-1 2021 Neopterin (NPT) is a member of pteridines group, synthesized by macrophages when stimulated by interferon gamma (INF-gamma). Neopterin 11-14 interferon gamma Homo sapiens 95-122 34319496-1 2021 Neopterin (NPT) is a member of pteridines group, synthesized by macrophages when stimulated by interferon gamma (INF-gamma). Pteridines 31-41 interferon gamma Homo sapiens 95-122 34481269-6 2021 Our results show that MVADelta008-OVA (optimized vector) induced higher in vivo specific cytotoxicity and ex vivo T-cell IFN-gamma responses against OVA than the conventional MVA vector. mvadelta008-ova 22-37 interferon gamma Homo sapiens 121-130 34541720-7 2021 Serum levels of IFN-gamma (p = .52) and IL-17 (p = .11) decreased, while IL-4 (p = .12) and TGF-beta (p = .14) increased in the nano-curcumin group compared with placebo on day 14. Curcumin 133-141 interferon gamma Homo sapiens 16-25 34757278-8 2021 Also, at both time points of before and after plasmapheresis, serum levels of IL-1, IL-6, IFN-gamma and IL-17 were inversely correlated to blood oxygen saturation. Oxygen 145-151 interferon gamma Homo sapiens 90-99 34397170-3 2021 Here, we demonstrate the capacity for interferon (IFN)-gamma licensing to enhance human MAPC efficacy and retention following early administration in a humanized mouse model of acute GvHD (aGvHD). mapc 88-92 interferon gamma Homo sapiens 38-60 34935183-8 2022 Administering emapalumab reduced IFNgamma activity, resulting in significant improvements in clinical and laboratory parameters and a reduced risk of adverse events, mainly related to pHLH. phlh 184-188 interferon gamma Homo sapiens 33-41 34935183-10 2022 CONCLUSIONS: The variable and unanticipated extremely high IFNgamma concentrations in patients with pHLH are reflected in parameters of disease activity. phlh 100-104 interferon gamma Homo sapiens 59-67 34776974-14 2021 In conclusion, LWWL had potent inhibitory effect on both wild-type and entecavir-resistant HBV, which might be associated with increasing IFN-beta and IFN-gamma production. entecavir 71-80 interferon gamma Homo sapiens 151-160 34769126-5 2021 Accordingly, human monocyte-derived macrophages expressed high basal levels of hPGDS and released significant levels of PGD2 after LPS/IFN-gamma, but not IL-4 stimulation. Prostaglandin D2 120-124 interferon gamma Homo sapiens 135-144 34768873-8 2021 Graphene exposure (10 microg/mL) for 24 h significantly increased levels of pro-inflammatory cytokines IFNgamma, IL-8, IL-17, IL-6, IL-9, MIP-1alpha, and Eotaxin. Graphite 0-8 interferon gamma Homo sapiens 103-111 34157324-6 2021 In vitro studies, steroid resistance model was induced by the TNF-alpha and IFN-gamma. Steroids 18-25 interferon gamma Homo sapiens 76-85 34157324-14 2021 The combination of TNF-alpha and IFN-gamma could conspicuously increase the GRbeta expression and reduce GRalpha/GRbeta, and induce steroid resistance in podocytes. Steroids 132-139 interferon gamma Homo sapiens 33-42 34157324-17 2021 The combination of TNF-alpha and IFN-gamma induce podocytes can establish steroid resistance model in vitro. Steroids 74-81 interferon gamma Homo sapiens 33-42 34759824-4 2021 After exposure to various concentration of decitabine for 24 h, the primary NK cells (AML-NK cells) cytotoxicity and receptor expression (NKG2D and NKp46) displayed parabola-shaped response, while U-shaped response was seen in cytokine release (IFN-gamma and IL-10), and these effects were regulated by ERK and STAT3 phosphorylation level. Decitabine 43-53 interferon gamma Homo sapiens 245-254 34687147-4 2022 In functional assays, pretreatment of EC with simvastatin to inhibit mevalonate metabolism resulted in a dose-dependent reduction in the costimulation of CD45RO+ CD4+ T cell proliferation as well as IL-2, IFNgamma and IL-6 production vs. vehicle-treated EC. Simvastatin 46-57 interferon gamma Homo sapiens 205-213 34687147-4 2022 In functional assays, pretreatment of EC with simvastatin to inhibit mevalonate metabolism resulted in a dose-dependent reduction in the costimulation of CD45RO+ CD4+ T cell proliferation as well as IL-2, IFNgamma and IL-6 production vs. vehicle-treated EC. Mevalonic Acid 69-79 interferon gamma Homo sapiens 205-213 34746009-12 2021 The frequencies of interferon-gamma (IFN-gamma) producing CD8+ and CD4+ T cells were significantly increased after being treated by the combination of UTMD and PDL-1 blockade, while the reactive oxygen species (ROS) production and the fraction of the TGF-beta-producing CD11b+ cells were significantly decreased. Reactive Oxygen Species 211-214 interferon gamma Homo sapiens 19-35 34733276-8 2021 In vitro treatment of PBMCs from either SLE patients or healthy controls with 17beta-estradiol at physiological concentration (~50 pg/ml) also significantly increased secretion of many pro-inflammatory cytokines and chemokines (IL-6, IL-12, IL-17, IL-8, IFN-gamma; MIP1alpha, and MIP1beta) in both groups. Estradiol 78-94 interferon gamma Homo sapiens 254-263 34733276-9 2021 Further our data revealed that 17beta-estradiol significantly increased the percentage of CD3+CD69+ and CD3+IFNgamma+ T cells; whereas, simultaneous addition of 17beta-estradiol and an ERalpha inhibitor prevented this effect. Estradiol 161-177 interferon gamma Homo sapiens 108-116 34733276-9 2021 Further our data revealed that 17beta-estradiol significantly increased the percentage of CD3+CD69+ and CD3+IFNgamma+ T cells; whereas, simultaneous addition of 17beta-estradiol and an ERalpha inhibitor prevented this effect. Estradiol 31-47 interferon gamma Homo sapiens 108-116 34627370-13 2021 Non-treated MenSCs decreased the frequency of Tregs, whereas after pre-treatment with IFN-gamma and IL-1beta, they induced functional Tregs with ability to inhibit the proliferation of anti-CD3/CD28-stimulated PBMCs. tregs 134-139 interferon gamma Homo sapiens 86-95 34721410-5 2021 Interferon-gamma (IFNgamma) Elispot and biochemical assays were used to functionally investigate the 21OH-specific T cells, and to map the exactly defined epitopes of 21OH. 21oh 167-171 interferon gamma Homo sapiens 0-16 34680134-7 2021 Preliminary methylation analysis shows that I2 activates IFNgamma gene promoter (by increasing its unmethylated form) and silences TGFbeta in Cht+I2. Iodine 44-46 interferon gamma Homo sapiens 57-65 34627370-16 2021 CONCLUSION: Collectively, these findings indicate that immunomodulatory impact of menstrual blood stem cells (MenSCs) on generation of Tregs and inhibition of T cells proliferation is largely dependent on pre-treatment with IFN-gamma and IL-1beta. tregs 135-140 interferon gamma Homo sapiens 224-233 34635423-0 2022 Multiple fixed drug eruption due to carbocysteine: Presence of circulating interferon-gamma-producing CD8+ T cells reactive with its night metabolite thiodiglycolic acid. Carbocysteine 36-49 interferon gamma Homo sapiens 75-91 34635423-0 2022 Multiple fixed drug eruption due to carbocysteine: Presence of circulating interferon-gamma-producing CD8+ T cells reactive with its night metabolite thiodiglycolic acid. thiodiacetic acid 150-169 interferon gamma Homo sapiens 75-91 34692475-17 2021 Conclusions: The preliminary data showed that the combination of anlotinib and anti-PD-1 antibodies demonstrated promising durable antitumor efficacy with acceptable toxicity in patients with various advance tumors, and promoted favorable changes in serum IL-2, IL-4, IL-10, TNF-alpha, IFN-gamma levels and circulating immune cell subsets in clinical responders. anlotinib 65-74 interferon gamma Homo sapiens 286-295 34691080-8 2021 Baseline endo-EV IFN-gamma and exo-EV IL-6 concentrations were also associated with rOA progression, but had low discriminant capacity (AUCs 0.558 and 0.518, respectively). ROA 84-87 interferon gamma Homo sapiens 17-26 34391837-4 2021 Herein, a platelet-engineered nanoplatform (PMF@DR NPs) capable of harmonizing janus-faced nature of IFN-gamma was designed via uniquely co-assembling doxorubicin (Dox) and cyclin-dependent kinase 5 inhibitor roscovitine (Rosco) with platelet membrane fragment (PMF) as the particulate stabilizer. Doxorubicin 151-162 interferon gamma Homo sapiens 101-110 34391837-4 2021 Herein, a platelet-engineered nanoplatform (PMF@DR NPs) capable of harmonizing janus-faced nature of IFN-gamma was designed via uniquely co-assembling doxorubicin (Dox) and cyclin-dependent kinase 5 inhibitor roscovitine (Rosco) with platelet membrane fragment (PMF) as the particulate stabilizer. Doxorubicin 164-167 interferon gamma Homo sapiens 101-110 34391837-4 2021 Herein, a platelet-engineered nanoplatform (PMF@DR NPs) capable of harmonizing janus-faced nature of IFN-gamma was designed via uniquely co-assembling doxorubicin (Dox) and cyclin-dependent kinase 5 inhibitor roscovitine (Rosco) with platelet membrane fragment (PMF) as the particulate stabilizer. Roscovitine 209-220 interferon gamma Homo sapiens 101-110 34391837-4 2021 Herein, a platelet-engineered nanoplatform (PMF@DR NPs) capable of harmonizing janus-faced nature of IFN-gamma was designed via uniquely co-assembling doxorubicin (Dox) and cyclin-dependent kinase 5 inhibitor roscovitine (Rosco) with platelet membrane fragment (PMF) as the particulate stabilizer. Roscovitine 222-227 interferon gamma Homo sapiens 101-110 34391837-5 2021 With PMF@DR NPs navigated by PMF to residual tumor, the Dox-activated immune response recovered IFN-gamma secretion for positive host"s immunity, while the IFN-gamma-induced negative adaptive immune resistance was potently overcome by Rosco via disabling PD-L1 expression without dependence of IFN-gamma stimulation. Doxorubicin 56-59 interferon gamma Homo sapiens 96-105 34721394-7 2021 In contrast, we observed a specific impact of teriflunomide on the CD8 T cell compartment, which was characterized by decreased homeostatic proliferation and reduced production of TNFalpha and IFNgamma. teriflunomide 46-59 interferon gamma Homo sapiens 193-201 34639073-1 2021 Our objective is to reveal the molecular mechanism of the anti-inflammatory action of low-molecular-weight heparin (LMWH) based on its influence on the activity of two key cytokines, IFNgamma and IL-6. Heparin 107-114 interferon gamma Homo sapiens 183-191 34639073-1 2021 Our objective is to reveal the molecular mechanism of the anti-inflammatory action of low-molecular-weight heparin (LMWH) based on its influence on the activity of two key cytokines, IFNgamma and IL-6. Heparin, Low-Molecular-Weight 116-120 interferon gamma Homo sapiens 183-191 34639073-2 2021 The mechanism of heparin binding to IFNgamma and IL-6 and the resulting inhibition of their activity were studied by means of extensive molecular-dynamics simulations. Heparin 17-24 interferon gamma Homo sapiens 36-44 34639073-3 2021 The effect of LMWH on IFNgamma signalling inside stimulated WISH cells was investigated by measuring its antiproliferative activity and the translocation of phosphorylated STAT1 in the nucleus. Heparin, Low-Molecular-Weight 14-18 interferon gamma Homo sapiens 22-30 34639073-4 2021 We found that LMWH binds with high affinity to IFNgamma and is able to fully inhibit the interaction with its cellular receptor. Heparin, Low-Molecular-Weight 14-18 interferon gamma Homo sapiens 47-55 34682144-9 2021 Following dexamethasone treatment, there were significant decreases in respiratory severity score (RSS), percent CD4+IL-6+ cells, CD8+IL-6+ cells, CXCR3+IL-6+ cells, and CXCR3+IL-2+ cells and total intracellular IFN-gamma in TA. Dexamethasone 10-23 interferon gamma Homo sapiens 212-221 34387375-6 2021 TAM-targeting depletion and hypoxia alleviation synergistically reprogram the TIME, which concurrently downregulate PD-L1 expression of tumor cells, decrease the levels of immunosuppressive cytokines such as IL-10 and TGF-beta, elevate the immunostimulatory IFN-gamma, enhance cytotoxic T lymphocyte (CTL) response, and boost a strong memory response. tam 0-3 interferon gamma Homo sapiens 258-267 34343543-9 2021 Similarly, after injection of live bacteria (Aeromonas salmonicida) or poly I:C the number of IFN-gamma+ cells increased in the lymphoid population of PBL, as well as in the myeloid population after infection, with the myeloid cells increasing substantially after both treatments. Poly I 71-77 interferon gamma Homo sapiens 94-103 34646402-2 2021 Objective: To examine the effects of genetic polymorphisms of IFNG, IFNGR1, and androgen receptor (AR) on CP/CPPS. cpps 109-113 interferon gamma Homo sapiens 62-66 34481291-5 2021 U4CpG treatment induced activation of plasmacytoid dendritic cells (pDCs) and natural killer (NK) cells in healthy human peripheral blood, which produced type I interferons (IFNs) and IFN-gamma in human peripheral blood mononuclear cells (PBMCs). u4cpg 0-5 interferon gamma Homo sapiens 184-193 34752316-4 2021 RESULTS: QuantiFERON TB Gold (QFT) which is interferon gamma release assay (IGRA) against Mtb antigen was used to quantify immunity status of patients against the tuberculosis. quantiferon tb gold 9-28 interferon gamma Homo sapiens 44-60 34314307-3 2021 The purpose of this study was for the first time to determine the effects of indoximod as an IDO inhibitor on triple-negative breast cancer (TNBC) and to assess the link between the efficacy of indoximod and IFN-gamma or TNF-alpha stimulation. 1-methyltryptophan 194-203 interferon gamma Homo sapiens 208-217 34229178-6 2021 Furthermore, this study revealed that treatment with AGC supported microglia transition from M1 to M2 in both oxygen-glucose deprivation/reperfusion (OGD/R) and LPS/IFN-gamma induced microglia cells, as well as indirectly inhibited LPS/IFN-gamma-induced neuronal damage through the modulation of microglial polarization. agc 53-56 interferon gamma Homo sapiens 165-174 34229178-6 2021 Furthermore, this study revealed that treatment with AGC supported microglia transition from M1 to M2 in both oxygen-glucose deprivation/reperfusion (OGD/R) and LPS/IFN-gamma induced microglia cells, as well as indirectly inhibited LPS/IFN-gamma-induced neuronal damage through the modulation of microglial polarization. agc 53-56 interferon gamma Homo sapiens 236-245 34638942-8 2021 Additionally, IFN-gamma inhibited TNF-alpha-induced migration of aVEC. avec 65-69 interferon gamma Homo sapiens 14-23 34900169-8 2021 Also, carvacrol significantly induced IFN-gamma production and did not induce IL-10 production. carvacrol 6-15 interferon gamma Homo sapiens 38-47 34720016-11 2021 IFNgamma level also correlated with the anti-dsDNA, iron serum, and ferritin levels. Iron 52-56 interferon gamma Homo sapiens 0-8 34720016-13 2021 Multivariate regression analysis showed that IFNgamma was positively associated with anti-dsDNA and negatively associated with iron serum and transferrin saturation, while CD8+CD57+ percentages were positively associated with the ferritin levels. Iron 127-131 interferon gamma Homo sapiens 45-53 34101276-7 2021 Resveratrol has been shown to induce the release of anticancer cytokines such as IFN-gamma and TNF-alpha and also inhibits the release of TGF-beta. Resveratrol 0-11 interferon gamma Homo sapiens 81-90 34455178-11 2021 RESULTS: After the stimulation of HaCaT cells with TNF-alpha/IFN-gamma, RDL considerably reduced the release of inflammatory mediators such as nitric oxide (NO), PEG2 and other cytokines. Nitric Oxide 143-155 interferon gamma Homo sapiens 61-70 34455178-11 2021 RESULTS: After the stimulation of HaCaT cells with TNF-alpha/IFN-gamma, RDL considerably reduced the release of inflammatory mediators such as nitric oxide (NO), PEG2 and other cytokines. peg2 162-166 interferon gamma Homo sapiens 61-70 34369213-9 2021 Furthermore, suPAR was positively correlated with Th1 cell proportion, Th17 cell proportion, IFN-gamma, IL-17 and TNF-alpha. supar 13-18 interferon gamma Homo sapiens 93-102 34686461-12 2022 Colchicine patients had numerically lower levels of pre-PCI cytokines: IL-1beta (p = 0.01), IL-6 (p = 0.02), IL-10 (p = 0.01), IFNgamma (p = 0.01), TNFalpha (p = 0.02) and WBC-count (p = 0.04). Colchicine 0-10 interferon gamma Homo sapiens 127-135 34631160-7 2021 The nAbs levels were positively correlated with the number of donor-reactive IFN-gamma-producing cells (r s = 0.39, p=0.004). nabs 4-8 interferon gamma Homo sapiens 77-86 34679041-11 2021 The transcription levels of IL-2, IFN-gamma, IL-4 and IL-10 cytokines in the TB-Cap, TB-Cap-CD154 and TB-Cap-GM-CSF groups were significantly higher than those in the PBS and recombinant vaccine groups (p < 0.0001). Terbium 77-79 interferon gamma Homo sapiens 34-43 34679041-11 2021 The transcription levels of IL-2, IFN-gamma, IL-4 and IL-10 cytokines in the TB-Cap, TB-Cap-CD154 and TB-Cap-GM-CSF groups were significantly higher than those in the PBS and recombinant vaccine groups (p < 0.0001). Terbium 102-104 interferon gamma Homo sapiens 34-43 34680642-5 2021 Moreover, the mRNA and protein expression levels of the inflammatory cytokines TNFalpha, IL-6, IL-1beta, and IFNgamma were increased by LPS, but were significantly reduced by AE-GBE treatment. ae-gbe 175-181 interferon gamma Homo sapiens 109-117 34581869-9 2022 Mechanistically, CpG-2722 shaped a tumor microenvironment that is favorable for the action of anti-PD-1, which included promoting the expression of different cytokines such as IL-12, IFN-beta, and IFN-gamma, and increasing the presence of plasmacytoid dendritic cells, M1 macrophages, and CD8 positive T cells. cpg-2722 17-25 interferon gamma Homo sapiens 197-206 34232994-4 2021 High doses of ruxolitinib blocked IFN-g signaling only transiently after administration, consistent with human pharmacokinetics, and only continuously administered drug could prevent HLH development or treat established HLH. ruxolitinib 14-25 interferon gamma Homo sapiens 34-39 34490414-4 2021 Almost all seropositive and 17.9% of seronegative patients on BCDT, enriched for a history of COVID-19-like symptoms, developed anti-SARS-CoV-2 T-cell memory and T-cells displayed functional similarity to controls producing IFN-gamma and TNF. bcdt 62-66 interferon gamma Homo sapiens 224-233 34232994-5 2021 Continuously administered ruxolitinib was therapeutic in only a narrow dose range and intermittently dosed ruxolitinib worsened survival and decreased bone marrow cellularity of animals concurrently treated with anti-IFN-g antibody, indicating a narrow therapeutic window and potential toxicity. ruxolitinib 107-118 interferon gamma Homo sapiens 217-222 34456075-5 2021 EXCT4 formulated with Advax-CpG adjuvant induced a strong Th1-type immune response characterized by interferon gamma (IFN-gamma) and protected animals against a lethal genital challenge with HSV-2. advax-cpg adjuvant 22-40 interferon gamma Homo sapiens 100-127 34630388-7 2021 GML down-regulate (P < 0.05) jejunal interleukin-1beta and interferon-gamma expression and increased (P < 0.05) the mRNA level of zonula occludens 1 and occludin. monolaurin 0-3 interferon gamma Homo sapiens 59-75 34550852-5 2021 The serum concentrations of IFN-gamma on days 7 and 15, and IL-4, IL-10, sIgA on days 7, 15 and 25 in APS-sEPS group were significantly higher than those in the control group (p < 0.05). aps-seps 102-110 interferon gamma Homo sapiens 28-37 34616298-5 2021 SHCGT alleviated DNCB-induced symptoms of AD and the immune response to AD by decreasing the plasma immunoglobulin E level and splenic interleukin-4, interleukin-10, TNF-alpha, and IFN-gamma levels. Dinitrochlorobenzene 17-21 interferon gamma Homo sapiens 181-190 34232708-3 2021 Results: By investigating a perceived increased rate of indeterminate QuantiFERON -TB Gold Plus results in hospitalized COVID patients, we demonstrate that severely ill COVID-19 patients have at least a 6-fold reduction of interferon-gamma (IFN-gamma) levels compared to control patients. quantiferon -tb gold 70-90 interferon gamma Homo sapiens 241-250 34232708-3 2021 Results: By investigating a perceived increased rate of indeterminate QuantiFERON -TB Gold Plus results in hospitalized COVID patients, we demonstrate that severely ill COVID-19 patients have at least a 6-fold reduction of interferon-gamma (IFN-gamma) levels compared to control patients. quantiferon -tb gold 70-90 interferon gamma Homo sapiens 223-239 34232708-8 2021 Conclusions: In addition to finding a significant limitation of IGRA testing severely ill COVID-19 patients, these data provide evidence that many of these patients demonstrate a focused Th2 immune response with inhibition of IFN-gamma signaling and, in many cases, significant elevations of IL-6. th2 187-190 interferon gamma Homo sapiens 226-235 34319803-3 2021 Methods: Interferon-gamma levels (stimulated by Mtb antigens (TB1 and TB2) and mitogen included in the QuantiFERON-TB Gold Plus assay) were measured in blood from pregnant HIV-negative women identified from a prospective cohort at Ethiopian antenatal care clinics. tb gold 115-122 interferon gamma Homo sapiens 9-25 34486371-6 2021 NKAB elicits both direct cytotoxicity and IFN-gamma production via integration of NKG2D and 2B4 signals. nkab 0-4 interferon gamma Homo sapiens 42-51 34566960-8 2021 Interferon-gamma levels decreased evidently on days 4, 6, and 8 after 6-OHDA treatment. Oxidopamine 70-76 interferon gamma Homo sapiens 0-16 34538552-10 2022 CONCLUSION: Higher serum TNF-alpha at baseline and lower IFN-gamma at week 4 were associated with mild clinical reactivation of HBV in patients with HBV/HCV co-infection receiving DAAs. daas 180-184 interferon gamma Homo sapiens 57-66 34420789-11 2021 T04 induced a low but detectable PCV2-specific IFN-gamma response only after the 2nd dose. T04 0-3 interferon gamma Homo sapiens 47-56 34497300-5 2021 Using LPS and IFN-gamma, macrophages were skewed toward M1 type and were treated with BzATP. BzATP 86-91 interferon gamma Homo sapiens 14-23 34691416-6 2021 Clinical discussion: Cyclosporine is an immunosuppressive agent that interferes with T-cells activation by inhibiting transcription of cytokines, such as interleukin 2 and interferon-gamma. Cyclosporine 21-33 interferon gamma Homo sapiens 172-188 34574235-14 2021 plantarum strains significantly decreased the mRNA expression of pro-inflammatory cytokines (i.e., IL-1beta, IL-6, and TNF-alpha); Wikim0112 significantly increased the mRNA expression of IL-4 and IFN-gamma. wikim0112 131-140 interferon gamma Homo sapiens 197-206 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Quercetin 101-110 interferon gamma Homo sapiens 278-282 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Berberine 122-131 interferon gamma Homo sapiens 278-282 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Luteolin 112-120 interferon gamma Homo sapiens 278-282 34500860-6 2021 We elucidated the anti-inflammatory effects of EAA on tumor necrosis factor-alpha/interferon-gamma (TNF-alpha/IFN-gamma)-treated human keratinocyte cells and 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like mice. ethyl acetoacetate 47-50 interferon gamma Homo sapiens 82-98 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. hederagenin 133-144 interferon gamma Homo sapiens 278-282 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. shionone 146-154 interferon gamma Homo sapiens 278-282 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. kaempferol 159-169 interferon gamma Homo sapiens 278-282 34579233-6 2021 The Montanide ISA 206B-adjuvanted vaccine elicited a higher SAT2 neutralizing antibody response and three times higher levels of systemic IFN-gamma responses at 14- and 28-days post-vaccination (dpv) were observed compared to the Quil-A Saponin-adjuvanted vaccine group. montanide isa 206b 4-22 interferon gamma Homo sapiens 138-147 34500860-6 2021 We elucidated the anti-inflammatory effects of EAA on tumor necrosis factor-alpha/interferon-gamma (TNF-alpha/IFN-gamma)-treated human keratinocyte cells and 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like mice. ethyl acetoacetate 47-50 interferon gamma Homo sapiens 110-119 34216770-6 2021 This report is the first demonstrating that Ara-C combined with DS can modulate immune responses and revert immunosuppression as evidenced by increased IFN-gamma and IL-12p40 without changes in IL-10 in peripheral blood mononuclear cells, and increased CD80 and decreased CD163 on immunosuppressive macrophages. Cytarabine 44-49 interferon gamma Homo sapiens 152-161 34139195-5 2021 We found that AA6216 is a more potent inhibitor of PDE4 and of cytokine production (TNF-alpha, IL-12/23p40, IL-4, IL-13, and IFN-gamma) by human peripheral blood mononuclear cells (PBMCs) stimulated by phytohemagglutinin (PHA) or anti-CD3 antibodies, with IC50 values ranging from 5.9 to 47 nM. aa6216 14-20 interferon gamma Homo sapiens 125-134 34216770-6 2021 This report is the first demonstrating that Ara-C combined with DS can modulate immune responses and revert immunosuppression as evidenced by increased IFN-gamma and IL-12p40 without changes in IL-10 in peripheral blood mononuclear cells, and increased CD80 and decreased CD163 on immunosuppressive macrophages. Deuterium 64-66 interferon gamma Homo sapiens 152-161 34216770-7 2021 Furthermore, Ara-C/DS increased MHC class I expression on cancer cells while increasing the production of antigen-specific IFN-gamma+ CD8+ T cells in viral peptide-challenged lymphocytes from both humans and vaccinated mice. Cytarabine 13-18 interferon gamma Homo sapiens 123-132 34500779-3 2021 The aim of this study was to investigate whether suppression of IFN-gamma induced PD-L1 expression in two oral cancer cell lines, HN6 and HN15, by hesperidin effectively decreased cell proliferation and migration. Hesperidin 147-157 interferon gamma Homo sapiens 64-73 34226674-5 2021 Restoring CD25 expression using the JAK1/3-inhibitor tofacitinib controlled TCR-induced IFNgamma secretion in vitro. tofacitinib 53-64 interferon gamma Homo sapiens 88-96 34107055-7 2021 In contrast, all 3 therapies disrupted IFNalpha and IFNbeta secretion in response to Spike-protein, nonetheless, the IFNgamma was only curtailed by Tofacitinib or IL-6R Ab. tofacitinib 148-159 interferon gamma Homo sapiens 117-125 34107055-9 2021 Nevertheless, the potentiated inflammatory response and the diminished oxidative phosphorylation modulated by Spike protein and/or LPS/IFNgamma stimulation in MPhis or RA FLS; were reversed by Tofacitinib. tofacitinib 193-204 interferon gamma Homo sapiens 135-143 34303919-6 2021 In an early phase, during the first 2 h of IFN-gamma treatment, STAT1 is phosphorylated at Tyrosine 701 and Serine 727, residues required for the induction of the transcription factor IRF1. Tyrosine 91-99 interferon gamma Homo sapiens 43-52 34303919-6 2021 In an early phase, during the first 2 h of IFN-gamma treatment, STAT1 is phosphorylated at Tyrosine 701 and Serine 727, residues required for the induction of the transcription factor IRF1. Serine 108-114 interferon gamma Homo sapiens 43-52 34365090-7 2021 Exposure to butyrate potently inhibited CD4 T cell activation, proliferation, and cytokine (IFNgamma, IL-17) production in a concentration dependent manner. Butyrates 12-20 interferon gamma Homo sapiens 92-100 34761621-10 2021 FAT10 was time-dependently upregulated in OS cells stimulated with IFN-gamma and TNF-alpha, which was dose-dependently downregulated by the treatment of AZ960. 5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile 153-158 interferon gamma Homo sapiens 67-76 34186122-5 2021 ANS/synchronous fluorescence, CD and UV-Vis spectroscopy studies indicated that the interaction between calycosin and IFN-gamma caused the folding of the IFN-gamma backbone in to a more packed structure with enhanced alpha-helix content and higher melting temperature (Tm) value. 7,3'-dihydroxy-4'-methoxyisoflavone 104-113 interferon gamma Homo sapiens 154-163 34171557-3 2021 Herein, we identified that interferon-gamma (IFN-gamma), one of the most important cytokines in the immune and inflammatory response, up-regulated CD47 expression in cancer cells and this effect could be inhibited by the JAK1/2 inhibitor ruxolitinib, as well as siRNA-mediated silencing of JAK1, STAT1, and IRF1. ruxolitinib 238-249 interferon gamma Homo sapiens 27-43 34171557-3 2021 Herein, we identified that interferon-gamma (IFN-gamma), one of the most important cytokines in the immune and inflammatory response, up-regulated CD47 expression in cancer cells and this effect could be inhibited by the JAK1/2 inhibitor ruxolitinib, as well as siRNA-mediated silencing of JAK1, STAT1, and IRF1. ruxolitinib 238-249 interferon gamma Homo sapiens 45-54 34186122-0 2021 Enhancement of interferon gamma stability as an anticancer therapeutic protein against hepatocellular carcinoma upon interaction with calycosin. 7,3'-dihydroxy-4'-methoxyisoflavone 134-143 interferon gamma Homo sapiens 15-31 34186122-2 2021 Herein, we explored the thermodynamic parameters and conformational stability of IFN-gamma in the presence of calycosin, the main active compound of Radix astragali, by different biophysical and theoretical analysis. 7,3'-dihydroxy-4'-methoxyisoflavone 110-119 interferon gamma Homo sapiens 81-90 34186122-3 2021 Afterwards, the improved anticancer effects of IFN-gamma-calycosin interaction relative to IFN-gamma alone were assessed on hepatocellular carcinoma (HepG2) cell line by MTT and caspase assays. monooxyethylene trimethylolpropane tristearate 170-173 interferon gamma Homo sapiens 47-56 34186122-4 2021 ITC data indicated that upon interaction of calycosin with IFN-gamma the binding and thermodynamic parameters were as follows: Kd = 1.9 muM, DeltaG = -32.45 kJ/mol, DeltaH = -11.91 kJ/mol, and TDeltaS = 20.54 kJ/mol. 7,3'-dihydroxy-4'-methoxyisoflavone 44-53 interferon gamma Homo sapiens 59-68 34186122-5 2021 ANS/synchronous fluorescence, CD and UV-Vis spectroscopy studies indicated that the interaction between calycosin and IFN-gamma caused the folding of the IFN-gamma backbone in to a more packed structure with enhanced alpha-helix content and higher melting temperature (Tm) value. 1-anilino-8-naphthalenesulfonate 0-3 interferon gamma Homo sapiens 118-127 34186122-5 2021 ANS/synchronous fluorescence, CD and UV-Vis spectroscopy studies indicated that the interaction between calycosin and IFN-gamma caused the folding of the IFN-gamma backbone in to a more packed structure with enhanced alpha-helix content and higher melting temperature (Tm) value. 1-anilino-8-naphthalenesulfonate 0-3 interferon gamma Homo sapiens 154-163 34186122-5 2021 ANS/synchronous fluorescence, CD and UV-Vis spectroscopy studies indicated that the interaction between calycosin and IFN-gamma caused the folding of the IFN-gamma backbone in to a more packed structure with enhanced alpha-helix content and higher melting temperature (Tm) value. Cadmium 30-32 interferon gamma Homo sapiens 118-127 34186122-5 2021 ANS/synchronous fluorescence, CD and UV-Vis spectroscopy studies indicated that the interaction between calycosin and IFN-gamma caused the folding of the IFN-gamma backbone in to a more packed structure with enhanced alpha-helix content and higher melting temperature (Tm) value. Cadmium 30-32 interferon gamma Homo sapiens 154-163 34186122-5 2021 ANS/synchronous fluorescence, CD and UV-Vis spectroscopy studies indicated that the interaction between calycosin and IFN-gamma caused the folding of the IFN-gamma backbone in to a more packed structure with enhanced alpha-helix content and higher melting temperature (Tm) value. 7,3'-dihydroxy-4'-methoxyisoflavone 104-113 interferon gamma Homo sapiens 118-127 34186122-7 2021 It was also shown that after incubation of the IFN-gamma samples at 50 C for 60 min in the presence of calycosin (5 muM), the IFN-gamma-calycosin system showed a significant antiproliferative effects against hepatocellular carcinoma (HepG2) cells through caspase-9/3 activation and this anticancer effect was more pronounced than free IFN-gamma. 7,3'-dihydroxy-4'-methoxyisoflavone 104-113 interferon gamma Homo sapiens 47-56 34186122-7 2021 It was also shown that after incubation of the IFN-gamma samples at 50 C for 60 min in the presence of calycosin (5 muM), the IFN-gamma-calycosin system showed a significant antiproliferative effects against hepatocellular carcinoma (HepG2) cells through caspase-9/3 activation and this anticancer effect was more pronounced than free IFN-gamma. 7,3'-dihydroxy-4'-methoxyisoflavone 104-113 interferon gamma Homo sapiens 127-136 34446555-3 2021 Here, we evaluated the immunosuppressive capacity, as measured by the ability to reduce T-cell proliferation and activation, of interferon-gamma (IFN-gamma)-licensed MSCs from multiple donors on fibrin and collagen hydrogels, the two most commonly utilized biomaterials in combination with MSCs in clinical trials worldwide according to ClinicalTrials.gov Variations in the immunosuppressive capacity between IFN-gamma-licensed MSC donors on the biomaterials correlated with the magnitude of indoleamine-2,3-dioxygenase activity. 1H-indol-2-amine 492-503 interferon gamma Homo sapiens 128-144 34446555-3 2021 Here, we evaluated the immunosuppressive capacity, as measured by the ability to reduce T-cell proliferation and activation, of interferon-gamma (IFN-gamma)-licensed MSCs from multiple donors on fibrin and collagen hydrogels, the two most commonly utilized biomaterials in combination with MSCs in clinical trials worldwide according to ClinicalTrials.gov Variations in the immunosuppressive capacity between IFN-gamma-licensed MSC donors on the biomaterials correlated with the magnitude of indoleamine-2,3-dioxygenase activity. 1H-indol-2-amine 492-503 interferon gamma Homo sapiens 146-155 34446555-3 2021 Here, we evaluated the immunosuppressive capacity, as measured by the ability to reduce T-cell proliferation and activation, of interferon-gamma (IFN-gamma)-licensed MSCs from multiple donors on fibrin and collagen hydrogels, the two most commonly utilized biomaterials in combination with MSCs in clinical trials worldwide according to ClinicalTrials.gov Variations in the immunosuppressive capacity between IFN-gamma-licensed MSC donors on the biomaterials correlated with the magnitude of indoleamine-2,3-dioxygenase activity. 1H-indol-2-amine 492-503 interferon gamma Homo sapiens 409-418 34175955-8 2021 Vancomycin-responsive CD4+ and CD8+ TCC from HLA-A*32:01+ donors expressed high levels of CXCR3 and CCR4, and secreted IFN-gamma, IL-13 and cytolytic molecules. Vancomycin 0-10 interferon gamma Homo sapiens 119-128 34429133-16 2021 Furthermore, apatinib pretreatment increased CD69 expression and IFN-gamma secretion in stimulated Jurkat T cells co-cultured with NSCLC cells. apatinib 13-21 interferon gamma Homo sapiens 65-74 34432268-7 2021 Metal ions markedly diminished the cytokine (interleukin-2 and interferon-gamma) secretion from activated lymphocytes. Metals 0-5 interferon gamma Homo sapiens 63-79 34415898-9 2021 Overall, IL-4 levels did not change significantly over time in either group; however, patients within the CE3b group showed a significant decrease of IL-1ra, IL-6, IL-8, G-CSF, IFN-gamma, IP-10, MCP-1, MIP-1alpha, FGF at T1 compared to T0 (p<=0.042). ce3b 106-110 interferon gamma Homo sapiens 177-186 34435034-11 2021 The 100 U mL-1 of IFN-gamma liposome significantly reduced the oxidative stress caused by H2O2 and appeared to be effective in both groups using the Comet and micronucleus assays. Hydrogen Peroxide 90-94 interferon gamma Homo sapiens 18-27 34429055-4 2021 Dopamine suppressed IL-17, IFN-gamma, GM-CSF, and IL-21 production by stimulated SD4+ T-cells in both groups. Dopamine 0-8 interferon gamma Homo sapiens 27-36 34429055-8 2021 Finally, activation of D2-like dopaminergic receptor with a specific agonist quinpirole decreased IL-17, IFN-gamma, and GM-CSF production in both groups. Quinpirole 77-87 interferon gamma Homo sapiens 105-114 34517463-3 2021 THP-1 transfected cells were induced into macrophages, lipopolysaccharide (LPS) and interferon gamma(IFNgamma) by phorbol 12-tetradecanoate 13-acetate (PMA), and then the polarized macrophages were further induced to M1 type. Tetradecanoylphorbol Acetate 114-150 interferon gamma Homo sapiens 84-110 34517463-3 2021 THP-1 transfected cells were induced into macrophages, lipopolysaccharide (LPS) and interferon gamma(IFNgamma) by phorbol 12-tetradecanoate 13-acetate (PMA), and then the polarized macrophages were further induced to M1 type. Tetradecanoylphorbol Acetate 152-155 interferon gamma Homo sapiens 84-110 34445589-12 2021 Most importantly, the effect of spermidine on edited cells restored normal expression and secretion of IFN-gamma and TNF-alpha. Spermidine 32-42 interferon gamma Homo sapiens 103-112 34483908-6 2021 Results: Under the stimulation of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), DHA inhibited the proliferation of HaCaT cells and significantly affected the mRNA expression levels of IFN-gamma, interleukin (IL), IL-17A and IL-23. artenimol 108-111 interferon gamma Homo sapiens 78-94 34483908-6 2021 Results: Under the stimulation of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), DHA inhibited the proliferation of HaCaT cells and significantly affected the mRNA expression levels of IFN-gamma, interleukin (IL), IL-17A and IL-23. artenimol 108-111 interferon gamma Homo sapiens 212-221 34483908-8 2021 DHA restored the expression of IFN-gamma, IL-17A, and IL-23 in skins, as well as a decrease of cytokines and chemokines in skin supernatant. artenimol 0-3 interferon gamma Homo sapiens 31-40 34413657-11 2021 After PBMCs pretreatment with BRD6989 (to enhance IL-10 secretion), average IFN-gamma concentrations in cell supernatants from the IGRA-positive group significantly decreased from 59.73 pg/mL to 33.79 pg/mL (P = 0.011). BRD6989 30-37 interferon gamma Homo sapiens 76-85 34445462-7 2021 Next, atorvastatin can inhibit the induction of PD-L1 by either IFNgamma alone or IFNgamma/TNFalpha combination treatment in HepG2 cells. Atorvastatin 6-18 interferon gamma Homo sapiens 64-72 34445462-7 2021 Next, atorvastatin can inhibit the induction of PD-L1 by either IFNgamma alone or IFNgamma/TNFalpha combination treatment in HepG2 cells. Atorvastatin 6-18 interferon gamma Homo sapiens 82-90 34413657-12 2021 By contrast, addition of AS101 (to inhibit IL-10 secretion) to false-negative group PBMCs led to an increase of average IFN-gamma concentration in cell supernatants from 19.01 pg/mL to 45.10 pg/mL (P = 0.030), a result that was inversely correlated with IL-10 concentration. ammonium trichloro(dioxoethylene-O,O'-)tellurate 25-30 interferon gamma Homo sapiens 120-129 34408814-6 2021 Results: H2S triggered the secretion of the pro-inflammatory IFN-gamma, IL-6, IL-17, TNF-alpha, IL-12p40, and IL-12p70, while the reverse was seen for IL-1Ra. Deuterium 9-12 interferon gamma Homo sapiens 61-70 34458148-3 2021 Regorafenib increased cell surface HLA-I and beta2-microglobulin protein expression in the presence of interferon gamma (IFNgamma). regorafenib 0-11 interferon gamma Homo sapiens 121-129 34458148-5 2021 Furthermore, we found that regorafenib had an activating effect on signal transducers and activators of transcription 1 (STAT1), and that regorafenib-induced HLA-I expression was dependent on the augmented IFNgamma/STAT1 signaling pathway. regorafenib 27-38 interferon gamma Homo sapiens 206-214 34458148-5 2021 Furthermore, we found that regorafenib had an activating effect on signal transducers and activators of transcription 1 (STAT1), and that regorafenib-induced HLA-I expression was dependent on the augmented IFNgamma/STAT1 signaling pathway. regorafenib 138-149 interferon gamma Homo sapiens 206-214 34458148-6 2021 Trametinib, an inhibitor of the extracellular signal-regulated kinase (ERK) kinase MEK, also activated IFNgamma/STAT1 signaling and increased HLA-I expression, whereas the phosphatidylinositol 3-kinase (PI3K) inhibitor buparlisib did not. trametinib 0-10 interferon gamma Homo sapiens 103-111 34447304-6 2021 We used the PBMCs collected from three healthy control participants with no known history of adverse drug reaction and two patients with a rifampicin-associated drug reaction with eosinophilia and systemic symptoms (DRESS), confirmed on IFN-gamma ELISpot assay. Rifampin 139-149 interferon gamma Homo sapiens 237-246 34447304-8 2021 Results: In a human immunodeficiency virus (HIV) negative and a positive rifampicin-associated DRESS with positive ex vivo IFN-gamma ELISpot assay, use of 10- and 100-fold Cmax drug concentrations decreased spot forming units/million cells by 32-100%, and this corresponded to cell cytotoxicity of more than 40 and 20% using an LDH assay and 7-AAD cell viability staining, respectively. Rifampin 73-83 interferon gamma Homo sapiens 123-132 34414234-8 2021 The Th1 cell subset and IFN-gamma levels were elevated in the dexmedetomidine-induced CD4+ T cells. Dexmedetomidine 62-77 interferon gamma Homo sapiens 24-33 34408924-4 2021 Here, we report that IFN-gamma rapidly increases protein synthesis and causes the unfolded protein response (UPR), as evidenced by the increased expression of glucose-regulated protein 78, activating transcription factor-4, and c/EBP homologous protein (CHOP) in cells treated with IFN-gamma. Glucose 159-166 interferon gamma Homo sapiens 21-30 34408924-4 2021 Here, we report that IFN-gamma rapidly increases protein synthesis and causes the unfolded protein response (UPR), as evidenced by the increased expression of glucose-regulated protein 78, activating transcription factor-4, and c/EBP homologous protein (CHOP) in cells treated with IFN-gamma. Glucose 159-166 interferon gamma Homo sapiens 282-291 34408924-8 2021 The ER stress inhibitor 4-PBA restored LAMP expression in IFN-gamma-treated cells. 4-phenylbutylamine 24-29 interferon gamma Homo sapiens 58-67 34408924-10 2021 The PERK inhibitor, GSK2606414, partially restored global protein synthesis and LAMP expression in cells treated with IFN-gamma. 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine 20-30 interferon gamma Homo sapiens 118-127 34445132-6 2021 In addition, saponarin (100 muM) significantly inhibited the expression of macrophage-derived chemokine, thymus and activation-regulated chemokine, IL-33, thymic stromal lymphopoietin, and the phosphorylation of signaling molecules (ERK, p38 and signal transducer and activator of transcription 1 (STAT1)) in TNF-alpha- and interferon (IFN)-gamma-stimulated HaCaT (human immortalized keratinocyte) cells. saponarin 13-22 interferon gamma Homo sapiens 324-346 34176228-4 2021 WEEV VLPs with 206 adjuvant could trigger a strong cellular immune response; increase the levels of IL-2, IL-4 and IFN-gamma; and induce a high level of neutralizing antibodies against WEEV in mice. 206 adjuvant 15-27 interferon gamma Homo sapiens 115-124 34414242-7 2021 Moreover, NDG isolated from the blood of both myeloma patients and healthy individuals could inhibit T-cell proliferation and IFN-gamma production. N-Acetyl-alpha-D-glucosamine 10-13 interferon gamma Homo sapiens 126-135 34382410-5 2021 Results: The expression of IFN-gamma in Lv-1645 cells was significantly increased compared to that in Jurkat-E6-1 cells stimulated by phorbol-12-myristate-13-acetate (PMA). Tetradecanoylphorbol Acetate 134-165 interferon gamma Homo sapiens 27-36 34170049-9 2021 Moreover, by inhibiting both JNK and ERK phosphorylation, TFNA exhibited significant suppressive effects on IFNgamma secretion from provoking T cells without affecting TNF secretion. 4-(Trifluoromethyl)nicotinic acid 58-62 interferon gamma Homo sapiens 108-116 34382410-5 2021 Results: The expression of IFN-gamma in Lv-1645 cells was significantly increased compared to that in Jurkat-E6-1 cells stimulated by phorbol-12-myristate-13-acetate (PMA). Tetradecanoylphorbol Acetate 167-170 interferon gamma Homo sapiens 27-36 34382410-7 2021 Silencing PCM1 significantly increased the level of IFN-gamma in Lv-1645 cells stimulated by PMA. Tetradecanoylphorbol Acetate 93-96 interferon gamma Homo sapiens 52-61 34382410-8 2021 Conclusion: This study revealed that lncRNA-ENST00000421645 mediates the production of IFN-gamma by sponging PCM1 protein after PMA stimulation. Tetradecanoylphorbol Acetate 128-131 interferon gamma Homo sapiens 87-96 34194560-13 2021 These results demonstrated that miR-155-5p activated the NF-kappaB signaling pathway, where treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate, reversed the effects of miR-155-5p overexpression on the inflammatory factors in IFN-gamma-induced SGECs. pyrrolidine dithiocarbamic acid 132-159 interferon gamma Homo sapiens 242-251 34194560-13 2021 These results demonstrated that miR-155-5p activated the NF-kappaB signaling pathway, where treatment with the NF-kappaB inhibitor, pyrrolidine dithiocarbamate, reversed the effects of miR-155-5p overexpression on the inflammatory factors in IFN-gamma-induced SGECs. mir-155-5p 185-195 interferon gamma Homo sapiens 242-251 34218330-7 2021 RESULTS: From in vitro experiments, we found that CCL19 enhanced the frequencies of Ag-responsive IFN-gamma+ CD8+ T cells from patients by approximately twofold, while CCR7 knockdown (LV-shCCR7) and LY294002 partially suppressed IFN-gamma secretion. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 199-207 interferon gamma Homo sapiens 229-238 34250593-14 2021 Further, we identified three curcuminoids partly responsible for this IFN-gamma-enhancing effect. Diarylheptanoids 29-41 interferon gamma Homo sapiens 70-79 34250593-17 2021 A mixture of three curcuminoids present in the extract exerted effects similar to whole CLE, demonstrating that the curcuminoids are partly responsible for the IFN-gamma-enhancing effect of C. longa. Diarylheptanoids 116-128 interferon gamma Homo sapiens 160-169 34318944-4 2021 Here, we found that IFNgamma treatment enhanced glutathione depletion, promoted cell cycle arrested in G0/G1 phase, increased lipid peroxidation, and sensitized cells to ferroptosis activators. Glutathione 48-59 interferon gamma Homo sapiens 20-28 34318944-5 2021 Additionally, IFNgamma down-regulated the mRNA and protein levels of SLC3A2 and SLC7A11, two subunits of the glutamate-cystine antiporter system xc- via activating the JAK/STAT pathway in hepatocellular carcinoma (HCC) cell lines. Glutamic Acid 109-118 interferon gamma Homo sapiens 14-22 34318944-5 2021 Additionally, IFNgamma down-regulated the mRNA and protein levels of SLC3A2 and SLC7A11, two subunits of the glutamate-cystine antiporter system xc- via activating the JAK/STAT pathway in hepatocellular carcinoma (HCC) cell lines. Cystine 119-126 interferon gamma Homo sapiens 14-22 34318944-6 2021 Furthermore, IFNgamma increased reactive oxygen species levels and decreased mitochondiral membrane potential in Bel7402 and HepG2 cells. Reactive Oxygen Species 32-55 interferon gamma Homo sapiens 13-21 34318944-8 2021 Cancer cells exposed to TGFbeta1 for 48 h showed sensitization to IFNgamma + erastin-induced ferroptosis, with decreased system xc- expression. erastin 77-84 interferon gamma Homo sapiens 66-74 34175589-6 2021 RESULTS: Obesity-associated AHR is ameliorated by administration of BCP by inhibition of the macrophage polarization by activation of AMPKalpha, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, up-regulation of adiponectin, GLP-1, IFN-gamma, SOD, catalase and down-regulation of NF-kappaB, leptin, IL-4, TNF, and IL-1beta. caryophyllene 68-71 interferon gamma Homo sapiens 235-244 34259987-6 2021 The results revealed that GEM-induced immune inhibition of M1-type RAW264.7 macrophages activated by interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). gemcitabine 26-29 interferon gamma Homo sapiens 101-117 34259987-6 2021 The results revealed that GEM-induced immune inhibition of M1-type RAW264.7 macrophages activated by interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). gemcitabine 26-29 interferon gamma Homo sapiens 119-128 34102301-8 2021 Besides, the production of IL-6 in LPS/IFN-gamma induced THP-1 cells was also decreased by both nucleosides. Nucleosides 96-107 interferon gamma Homo sapiens 39-48 34102236-8 2021 Importantly, in a mouse model, SP-E2-mi3 nanovaccines against Classical swine fever virus (CSFV) remarkably improved CSFV-specific neutralizing antibodies (NAbs) and cellular immunity related cytokines (IFN-gamma and IL-4) as compared to monomeric E2. sp-e2-mi3 nanovaccines 31-53 interferon gamma Homo sapiens 203-212 34171790-3 2021 QuantiFERON-TB Gold Plus (QFT-Plus), a new Interferon-gamma release assay, includes a new antigen tube (TB2), which elicits CD4+ and CD8+ T-cell responses. quantiferon-tb gold plus 0-24 interferon gamma Homo sapiens 43-59 34171790-3 2021 QuantiFERON-TB Gold Plus (QFT-Plus), a new Interferon-gamma release assay, includes a new antigen tube (TB2), which elicits CD4+ and CD8+ T-cell responses. -plus 29-34 interferon gamma Homo sapiens 43-59 34361003-9 2021 Through in vitro studies, we found that neferine inhibited the expression of cytokines and chemokines in TNF-alpha/IFN-gamma-stimulated human keratinocyte (HaCaT) cells, and it reduced the phosphorylation of MAPK and the NF-kappaB signaling pathway. neferine 40-48 interferon gamma Homo sapiens 115-124 34326162-5 2021 Patients who responded to vidutolimod and pembrolizumab had noninflamed tumors at baseline and induction of an interferon-gamma gene signature following treatment, as well as increased systemic expression of the interferon-inducible chemokine CXCL10. vidutolimod 26-37 interferon gamma Homo sapiens 111-127 34393993-5 2021 The aim of the study was to measure the level of plasma butyrate in poorly controlled T2DM and normoglycemic participants and to compare the response of peripheral blood mononuclear cells (PBMCs) to sodium butyrate treatment between the groups by measuring production of the following cytokines: tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, interferon (IFN)-gamma, IL-13, and IL-10. Butyric Acid 199-214 interferon gamma Homo sapiens 351-373 34360313-8 2021 TB antigen-stimulated IFN-gamma, I-TAC, and MIG levels were all significantly higher in the TB-LAP patients than in the controls and non-TB-LAP patients. Terbium 0-2 interferon gamma Homo sapiens 22-31 34360313-8 2021 TB antigen-stimulated IFN-gamma, I-TAC, and MIG levels were all significantly higher in the TB-LAP patients than in the controls and non-TB-LAP patients. Terbium 92-94 interferon gamma Homo sapiens 22-31 34360313-10 2021 Area under the receiver operating characteristic curves (AUROCs) of IFN-gamma, I-TAC, and MIG were 0.955, 0.958, and 0.959, respectively, for differentiating TB-LAP from control group, and were 0.912, 0.956, and 0.936, respectively, for differentiating TB-LAP from non-TB-LAP. Terbium 158-160 interferon gamma Homo sapiens 68-77 34385920-10 2021 It also increased cholesterol efflux significantly by1.64-fold and 1.60-fold either alone or in combination with IFN-gamma, respectively. Cholesterol 18-29 interferon gamma Homo sapiens 113-122 34512148-3 2021 RS-5645 also significantly reduced the cellular ratios of CD45+/IFNgamma+, CD3+/IFNgamma+, CD11b+/IFNgamma+, and CD56+/IFNgamma+ in human PBMCs. rs-5645 0-7 interferon gamma Homo sapiens 64-72 34512148-3 2021 RS-5645 also significantly reduced the cellular ratios of CD45+/IFNgamma+, CD3+/IFNgamma+, CD11b+/IFNgamma+, and CD56+/IFNgamma+ in human PBMCs. rs-5645 0-7 interferon gamma Homo sapiens 80-88 34512148-3 2021 RS-5645 also significantly reduced the cellular ratios of CD45+/IFNgamma+, CD3+/IFNgamma+, CD11b+/IFNgamma+, and CD56+/IFNgamma+ in human PBMCs. rs-5645 0-7 interferon gamma Homo sapiens 98-106 34512148-3 2021 RS-5645 also significantly reduced the cellular ratios of CD45+/IFNgamma+, CD3+/IFNgamma+, CD11b+/IFNgamma+, and CD56+/IFNgamma+ in human PBMCs. rs-5645 0-7 interferon gamma Homo sapiens 119-127 34393993-10 2021 Compared to treatment with an LPS-stimulated PBMC culture, treatment with 1 mM sodium butyrate reduced the levels of TNF-alpha (p < 0.039) and IFN-gamma (p < 0.038) in normoglycemic participants. Butyric Acid 79-94 interferon gamma Homo sapiens 143-152 34282445-9 2022 In multivariate analysis, interferon (IFN) gamma (gamma) levels (OR = 4.1; 95% 2.01-7.9) and depressive symptoms (OR = 1.9; 95%CI = 1.1-3.2) were associated with NAA/Cr ratio. 1-naphthaleneacetic acid 162-165 interferon gamma Homo sapiens 26-48 34275248-12 2021 The production of IFN-gamma was increased and the secretion of CD107a was decreased in NK cell and its subsets after DAAs treatment (P<0.05). daas 117-121 interferon gamma Homo sapiens 18-27 34076474-2 2021 Interferon-gamma (IFN-gamma) release assays, such as the QuantiFERON-TB Gold Plus test (QFT-Plus), are now widely implemented for the in vitro diagnosis of LTBI. quantiferon-tb gold 57-77 interferon gamma Homo sapiens 0-16 34076474-2 2021 Interferon-gamma (IFN-gamma) release assays, such as the QuantiFERON-TB Gold Plus test (QFT-Plus), are now widely implemented for the in vitro diagnosis of LTBI. quantiferon-tb gold 57-77 interferon gamma Homo sapiens 18-27 34280220-3 2021 TG6-44 significantly decreased A/X31-induced ROS and virus-induced inflammatory mediators in THP-1 cells (IL-6, IFN-gamma, MCP-1, TNF-alpha, MIP-1beta) and in human PBMC (IL-6, IL-8, TNF-alpha, MCP-1). 6-O-phosphono-D-tagatose 0-3 interferon gamma Homo sapiens 112-121 34275451-10 2021 Kaempferol-treatment could induce higher levels of IL-1beta, IL-4, IL-6, TNF-alpha and IFN-gamma in the serum at 3 dpi which were then declined to normal levels at 5 dpi. kaempferol 0-10 interferon gamma Homo sapiens 87-96 34299256-8 2021 IVIg/steroid treatment significantly decreased IFN-gamma and IL-10 expression. Steroids 5-12 interferon gamma Homo sapiens 47-56 34270559-0 2021 Mycobacterial heparin-binding hemagglutinin (HBHA)-induced interferon-gamma release assay (IGRA) for discrimination of latent and active tuberculosis: A systematic review and meta-analysis. Heparin 14-21 interferon gamma Homo sapiens 59-75 34377305-13 2021 After the therapy, the patients" serum IFN-gamma and IL-4 levels in GB were significantly better than they were in GA. After the therapy, the quality of life of the patients in GB was significantly higher than it was in in GA (P<0.05). gb 68-70 interferon gamma Homo sapiens 39-48 34377305-13 2021 After the therapy, the patients" serum IFN-gamma and IL-4 levels in GB were significantly better than they were in GA. After the therapy, the quality of life of the patients in GB was significantly higher than it was in in GA (P<0.05). gb 177-179 interferon gamma Homo sapiens 39-48 34282445-9 2022 In multivariate analysis, interferon (IFN) gamma (gamma) levels (OR = 4.1; 95% 2.01-7.9) and depressive symptoms (OR = 1.9; 95%CI = 1.1-3.2) were associated with NAA/Cr ratio. Chromium 166-168 interferon gamma Homo sapiens 26-48 34225667-11 2021 With the frequencies of total TNF-alpha- and total IFN-gamma-secreting T cells stimulated by ESAT-6 peptides combined, the specificity was increased to 97.1%, and the positive likelihood ratio to 31.5. esat-6 peptides 93-108 interferon gamma Homo sapiens 51-60 34215653-7 2021 T cell-mediated response directed against cancer cells was tested on treatment with a TCR-like TCB, which was able to bridge human T cells to a WT1 peptide displayed on MHC I. FKBP12F36V degrader treatment increased the expression of early and late activation markers (CD69, CD25) in T cells; the secretion of granzyme beta, IFN-gamma, and TNF-alpha; and cancer cell killing in a tumor-T cell coculture model. tcb 95-98 interferon gamma Homo sapiens 325-334 34257408-9 2021 JNJ-809 transiently induced peripheral cytokines, including interferon-gamma, interleukin-10, and tumor necrosis factor-alpha. jnj-809 0-7 interferon gamma Homo sapiens 60-76 34299030-8 2021 TNFalpha stimulated the cytokine expression in FLS, and NDMVs down-regulated TNFalpha-induced expression of IL-5, IL-6, IL-8, MCP-1, IFNgamma and MIP-1beta. ndmvs 56-61 interferon gamma Homo sapiens 133-141 34164977-9 2021 In the cell imaging experiment, the intracellular pH was adjusted using H+/K+ ionophore and nigericin, and the endogenous ONOO- was generated by lipopolysaccharide (LPS) and gamma-interferon (IFN-gamma). oxido nitrite 122-127 interferon gamma Homo sapiens 192-201 34358160-6 2021 Further, poly (I:C) significantly increased the frequency of IFN-gamma-expressing cells compared with control, whereas no significant difference was observed between the adjuvanted groups. Poly I-C 9-19 interferon gamma Homo sapiens 61-70 34233193-4 2021 ADWA-11 increases expression of a suite of genes in tumor-infiltrating CD8+ T cells normally inhibited by TGF-beta and involved in tumor cell killing, including granzyme B and interferon-gamma. adwa-11 0-7 interferon gamma Homo sapiens 176-192 34414894-9 2021 The combination of theophylline and budesonide suppressed synthesis of IL-4 and CXCL8 by NK and NKT-like cells, as well as the production of TNFalpha and IFNgamma by NK cells stronger than budesonide alone. Theophylline 19-31 interferon gamma Homo sapiens 154-162 34414894-9 2021 The combination of theophylline and budesonide suppressed synthesis of IL-4 and CXCL8 by NK and NKT-like cells, as well as the production of TNFalpha and IFNgamma by NK cells stronger than budesonide alone. Budesonide 36-46 interferon gamma Homo sapiens 154-162 34414894-6 2021 Budesonide reduced synthesis of interleukin 4 (IL-4), CXCL8, tumor necrosis factor alpha (TNFalpha) by NK and NKT-like cells, as well as production of interferon gamma (IFNgamma) by NK cells. Budesonide 0-10 interferon gamma Homo sapiens 151-167 34414894-9 2021 The combination of theophylline and budesonide suppressed synthesis of IL-4 and CXCL8 by NK and NKT-like cells, as well as the production of TNFalpha and IFNgamma by NK cells stronger than budesonide alone. Budesonide 189-199 interferon gamma Homo sapiens 154-162 34414894-6 2021 Budesonide reduced synthesis of interleukin 4 (IL-4), CXCL8, tumor necrosis factor alpha (TNFalpha) by NK and NKT-like cells, as well as production of interferon gamma (IFNgamma) by NK cells. Budesonide 0-10 interferon gamma Homo sapiens 169-177 34230114-11 2021 Treatment with INO-1400/INO-1401+-INO-9012 drove hTERT-specific IFN-gamma production, generated hTERT-specific CD4+ and CD8+ T cells expressing the activation marker CD38, and induced hTERT-specific activated CD8 +CTLs as defined by cells expressing perforin and granzymes. ino-1400 15-23 interferon gamma Homo sapiens 64-73 34230114-11 2021 Treatment with INO-1400/INO-1401+-INO-9012 drove hTERT-specific IFN-gamma production, generated hTERT-specific CD4+ and CD8+ T cells expressing the activation marker CD38, and induced hTERT-specific activated CD8 +CTLs as defined by cells expressing perforin and granzymes. ino-1401+-ino-9012 24-42 interferon gamma Homo sapiens 64-73 34244307-12 2021 The combination of dinutuximab and N-803 significantly enhanced in vitro cytotoxicity of exPBNK with enhanced perforin and IFN-gamma release against OS, GBM and NB. n-803 35-40 interferon gamma Homo sapiens 123-132 34125375-9 2021 RESULTS: HMBPP-stimulated gammadelta T cells cultured with GBM or its conditioned medium increased CD69, intracellular perforin, IFN-gamma, and TNF-alpha production. (E)-4-hydroxy-3-methylbut-2-enyl diphosphate 9-14 interferon gamma Homo sapiens 129-138 34244307-12 2021 The combination of dinutuximab and N-803 significantly enhanced in vitro cytotoxicity of exPBNK with enhanced perforin and IFN-gamma release against OS, GBM and NB. expbnk 89-95 interferon gamma Homo sapiens 123-132 34261033-8 2021 In the strongest multiple regression model, CXCL10/IP-10, VEGFA, IFN-gamma, CRP and Factor D/Adipsin explained 52% of the variation in overall maximal FDG uptake. Fluorodeoxyglucose F18 151-154 interferon gamma Homo sapiens 65-74 34087700-4 2021 Similarly, PS at a dosage of 20 and 40 mg/kg increased the concentrations of interleukin-1beta, interferon-gamma, interleukin-2, and interleukin-6 but decreased triglyceride, total cholesterol, and low-density lipoprotein cholesterol content of serum (P < 0.05). Phytosterols 11-13 interferon gamma Homo sapiens 96-112 34110682-3 2021 Here, an intelligent aptameric dual channel graphene-TWEEN 80 field effect transistor (DGTFET) biosensing device for on-site detection of IFN-gamma, TNF-alpha, and IL-6 within 7 min with limits of detection (LODs) of 476 x 10-15 , 608 x 10-15 , or 611 x 10-15 m respectively in biofluids is presented. Graphite 44-52 interferon gamma Homo sapiens 138-147 34110682-3 2021 Here, an intelligent aptameric dual channel graphene-TWEEN 80 field effect transistor (DGTFET) biosensing device for on-site detection of IFN-gamma, TNF-alpha, and IL-6 within 7 min with limits of detection (LODs) of 476 x 10-15 , 608 x 10-15 , or 611 x 10-15 m respectively in biofluids is presented. Polysorbates 53-61 interferon gamma Homo sapiens 138-147 34188068-8 2021 YIV-906 could potentiate the action of interferon gamma (IFNg) to increase M1-like macrophage polarization while inhibiting IL4 action to decrease M2 macrophage polarization. yiv-906 0-7 interferon gamma Homo sapiens 39-55 34277112-8 2021 In addition, K284 treatment inhibited the expression of NF-kappaB activity in PA-treated skin tissues and TNF-alpha and IFN-gamma-treated HaCaT cells. methylene iodide 13-17 interferon gamma Homo sapiens 120-129 34619854-13 2021 The level of IFN-gamma in CD8+T cells group after applying tacrolimus was significantly lower than that in the blank control group (P<0.05). Tacrolimus 59-69 interferon gamma Homo sapiens 13-22 34188068-8 2021 YIV-906 could potentiate the action of interferon gamma (IFNg) to increase M1-like macrophage polarization while inhibiting IL4 action to decrease M2 macrophage polarization. yiv-906 0-7 interferon gamma Homo sapiens 57-61 34188068-9 2021 Flavonoids from YIV-906 were responsible for modulating IDO activity and potentiating IFNg action in M1-like macrophage polarization. Flavonoids 0-10 interferon gamma Homo sapiens 86-90 34176483-6 2021 The sensitivity, specificity and AUC (area under curve) of "CD27-IFN-gamma+CD4+" cells to distinguish SN-TBs from HCs and TB-Cs were determined by receiver operating characteristic (ROC) curve analysis. sn-tbs 102-108 interferon gamma Homo sapiens 65-74 34176483-6 2021 The sensitivity, specificity and AUC (area under curve) of "CD27-IFN-gamma+CD4+" cells to distinguish SN-TBs from HCs and TB-Cs were determined by receiver operating characteristic (ROC) curve analysis. Tubercidin 122-127 interferon gamma Homo sapiens 65-74 34176483-8 2021 RESULTS: We observed that the percentages of "CD27-IFN-gamma+CD4+" cells were significantly increased in the SN-TB group compared with the HC and TB-C groups (AUC was 0.88, sensitivity was 82.14%, specificity was 80.00%, and P < 0.0001). sn-tb 109-114 interferon gamma Homo sapiens 51-60 34176483-8 2021 RESULTS: We observed that the percentages of "CD27-IFN-gamma+CD4+" cells were significantly increased in the SN-TB group compared with the HC and TB-C groups (AUC was 0.88, sensitivity was 82.14%, specificity was 80.00%, and P < 0.0001). Terbium 146-148 interferon gamma Homo sapiens 51-60 34176483-11 2021 CONCLUSION: The present results demonstrated that the percentage of "CD27-IFN-gamma+CD4+" cells might be a conceivable molecular indicator in the diagnosis of SN-TB and was influenced by its outcome of therapy. sn-tb 159-164 interferon gamma Homo sapiens 74-83 34206740-5 2021 Here, we show that IFN-gamma or exposure to culture media low in fetal bovine serum (FBS) increases sialylated N-glycans, while PDGF-BB reduces them. n-glycans 111-120 interferon gamma Homo sapiens 19-28 34206987-7 2021 A pronounced stimulation of cell proliferation and interferon-gamma (IFN-gamma) secretion in response to concanavalin A was shown for antioxidant N-acetylcysteine (NAC), polyamine biosynthesis inhibitor 2-difluoromethylornithine (DFMO), and TLR9 agonist CpG ODN 1826 (CpG). Acetylcysteine 146-162 interferon gamma Homo sapiens 51-67 34262557-0 2021 Low-Dose Vitamin D3 Supplementation Does Not Affect Natural Regulatory T Cell Population but Attenuates Seasonal Changes in T Cell-Produced IFN-gamma: Results From the D-SIRe2 Randomized Controlled Trial. Cholecalciferol 9-19 interferon gamma Homo sapiens 140-149 34262557-11 2021 Vitamin D attenuated the seasonal increase in IFN-gamma by ~28% with mean ng/ml (SEM) for placebo vs vitamin D, respectively, for April 12.5(1.4) vs 10.0(1.2) (p=0.02); June 13.9(1.3) vs 10.2(1.7) (p=0.02) and January 7.4(1.1) vs 6.0(1.1) (p=0.04). Vitamin D 0-9 interferon gamma Homo sapiens 46-55 34262557-14 2021 Vitamin D attenuated the seasonal change in T cell-produced IFN-gamma, suggesting a decrease in effector response which could be associated with inflammation. Vitamin D 0-9 interferon gamma Homo sapiens 60-69 34202367-10 2021 However, CVNE reduced the levels of the pro-inflammatory cytokines IL-2, IL-17, and IFN-gamma at 50 microM. cvne 9-13 interferon gamma Homo sapiens 84-93 34206987-7 2021 A pronounced stimulation of cell proliferation and interferon-gamma (IFN-gamma) secretion in response to concanavalin A was shown for antioxidant N-acetylcysteine (NAC), polyamine biosynthesis inhibitor 2-difluoromethylornithine (DFMO), and TLR9 agonist CpG ODN 1826 (CpG). Acetylcysteine 146-162 interferon gamma Homo sapiens 69-78 34206987-7 2021 A pronounced stimulation of cell proliferation and interferon-gamma (IFN-gamma) secretion in response to concanavalin A was shown for antioxidant N-acetylcysteine (NAC), polyamine biosynthesis inhibitor 2-difluoromethylornithine (DFMO), and TLR9 agonist CpG ODN 1826 (CpG). Acetylcysteine 164-167 interferon gamma Homo sapiens 51-67 34206987-7 2021 A pronounced stimulation of cell proliferation and interferon-gamma (IFN-gamma) secretion in response to concanavalin A was shown for antioxidant N-acetylcysteine (NAC), polyamine biosynthesis inhibitor 2-difluoromethylornithine (DFMO), and TLR9 agonist CpG ODN 1826 (CpG). Acetylcysteine 164-167 interferon gamma Homo sapiens 69-78 34206987-7 2021 A pronounced stimulation of cell proliferation and interferon-gamma (IFN-gamma) secretion in response to concanavalin A was shown for antioxidant N-acetylcysteine (NAC), polyamine biosynthesis inhibitor 2-difluoromethylornithine (DFMO), and TLR9 agonist CpG ODN 1826 (CpG). Eflornithine 203-228 interferon gamma Homo sapiens 51-67 34206987-7 2021 A pronounced stimulation of cell proliferation and interferon-gamma (IFN-gamma) secretion in response to concanavalin A was shown for antioxidant N-acetylcysteine (NAC), polyamine biosynthesis inhibitor 2-difluoromethylornithine (DFMO), and TLR9 agonist CpG ODN 1826 (CpG). Eflornithine 203-228 interferon gamma Homo sapiens 69-78 34206987-7 2021 A pronounced stimulation of cell proliferation and interferon-gamma (IFN-gamma) secretion in response to concanavalin A was shown for antioxidant N-acetylcysteine (NAC), polyamine biosynthesis inhibitor 2-difluoromethylornithine (DFMO), and TLR9 agonist CpG ODN 1826 (CpG). Eflornithine 230-234 interferon gamma Homo sapiens 51-67 34206987-7 2021 A pronounced stimulation of cell proliferation and interferon-gamma (IFN-gamma) secretion in response to concanavalin A was shown for antioxidant N-acetylcysteine (NAC), polyamine biosynthesis inhibitor 2-difluoromethylornithine (DFMO), and TLR9 agonist CpG ODN 1826 (CpG). Eflornithine 230-234 interferon gamma Homo sapiens 69-78 34177139-4 2021 CS is marked by elevated levels of inflammatory cytokines, mainly interleukin-6 (IL-6), IL-8, IL-10, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Cesium 0-2 interferon gamma Homo sapiens 146-162 34284852-5 2021 During 3-6 months of treatment, compared with baseline, the PEG-IFN group showed a significant decrease in interferon-gamma (IFN-gamma), interleukin-17A (IL-17A), interleukin-6(IL-6), interleukin-10(IL-10), and transforming growth factor beta (TGF-beta) ( P < 0.001) and a significant increase in interferon-alpha 2(IFN-alpha2) ( P < 0.001). peg-ifn 60-67 interferon gamma Homo sapiens 107-123 34284852-5 2021 During 3-6 months of treatment, compared with baseline, the PEG-IFN group showed a significant decrease in interferon-gamma (IFN-gamma), interleukin-17A (IL-17A), interleukin-6(IL-6), interleukin-10(IL-10), and transforming growth factor beta (TGF-beta) ( P < 0.001) and a significant increase in interferon-alpha 2(IFN-alpha2) ( P < 0.001). peg-ifn 60-67 interferon gamma Homo sapiens 125-134 34284852-9 2021 After 6 months, the levels of IFN-alpha2, IFN-gamma, and TNF-alpha in the PEG-IFN group were significantly higher than those in the ETV group ( P < 0.01), while the levels of IL-6 and TGF-beta3 were significantly lower than those in the ETV group ( P < 0.01). peg-ifn 74-81 interferon gamma Homo sapiens 42-51 34207431-0 2021 Fabrication of an Electrochemical Aptasensor Composed of Multifunctional DNA Three-Way Junction on Au Microgap Electrode for Interferon Gamma Detection in Human Serum. Gold 99-101 interferon gamma Homo sapiens 125-141 34207431-4 2021 Each multifunctional triple-stranded aptamer (MF-3WJ) was designed to have an IFN-gamma aptamer sequence, anchoring region (thiol group), and 4C-C (cytosine-cytosine) mismatch sequence (signal generation), which could introduce silver ions. Silver 228-234 interferon gamma Homo sapiens 78-87 34177139-4 2021 CS is marked by elevated levels of inflammatory cytokines, mainly interleukin-6 (IL-6), IL-8, IL-10, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Cesium 0-2 interferon gamma Homo sapiens 164-173 34220507-8 2021 Significantly, our results showed that Myricetin has potent effect on bleomycin-induced pulmonary inflammation by inhibiting the infiltration of inflammatory cells and the secretion of inflammatory cytokines IL-6, IL-1alpha, TNF-alpha and IFN-gamma. myricetin 39-48 interferon gamma Homo sapiens 239-248 34220507-8 2021 Significantly, our results showed that Myricetin has potent effect on bleomycin-induced pulmonary inflammation by inhibiting the infiltration of inflammatory cells and the secretion of inflammatory cytokines IL-6, IL-1alpha, TNF-alpha and IFN-gamma. Bleomycin 70-79 interferon gamma Homo sapiens 239-248 34177582-27 2021 Besides, angelicin can also protect and maintain M2 polarization in the presence of LPS/IFN-gamma, and subsequently downregulate the expression of inflammatory mediators such as IL-1beta and TNF-alpha. angelicin 9-18 interferon gamma Homo sapiens 88-97 34208434-0 2021 Skullcapflavone II Suppresses TNF-alpha/IFN-gamma-Induced TARC, MDC, and CTSS Production in HaCaT Cells. skullcapflavone II 0-18 interferon gamma Homo sapiens 40-49 34723044-5 2021 T cells and T cell-derived IFN-gamma are crucial for increasing inflammatory macrophage levels in IR and RA treated tumors. Tretinoin 105-107 interferon gamma Homo sapiens 27-36 34195241-3 2021 The BPC supplementation during gestation of sows downregulated the neonate piglets" jejunal genes involved in oxidation (SOD2) and nutrient transport (SLC16A1/MCT1, SLC11A2/DMT1, and SLC39A/ZIP4), while IFNG and CLDN4 related to immune response and barrier function, respectively, were upregulated (q < 0.10). bpc 4-7 interferon gamma Homo sapiens 203-207 34108550-7 2021 Significant positive correlations between triglyceride levels and hs-CRP, IL-1beta, and IFN-gamma concentrations, and between Apo B and IFN-gamma levels were observed 6 months after bariatric and metabolic surgery. Triglycerides 42-54 interferon gamma Homo sapiens 88-97 34201079-4 2021 HLA-E was induced in EwS cells by IFN-gamma stimulation in vitro and by GD2-specific CART treatment in vivo and was detected on tumor cells or infiltrating myeloid cells in a majority of human EwS biopsies. hla-e 0-5 interferon gamma Homo sapiens 34-43 34164359-6 2021 GSEA enrichment analysis showed that the IRGS, including interferon-inducible chemokines such as CXCL9, CXCL10, CXCL11, and IFNgamma itself, was more highly expressed in LS patients with more inflammatory lesions. gsea 0-4 interferon gamma Homo sapiens 125-133 34099809-5 2021 Moreover, the ssRNA adjuvant markedly increased the frequency of influenza HA-specific T cells and IFN-gamma production along with the expression of genes related to innate and adaptive immune systems that could overcome immunosenescence in aged mice. ssrna adjuvant 14-28 interferon gamma Homo sapiens 99-108 34088327-8 2021 RESULTS: Lithium was shown to stimulate interferon-gamma (IFN-gamma) production as early as 3 h pi. Lithium 9-16 interferon gamma Homo sapiens 40-56 34149708-8 2021 Measurement for 15 psoriatic patients (12 with HBHA-IGRA+) of 8 chemokines in addition to IFN-gamma revealed a broad array of HBHA-induced chemokines for TST+QFT- and TST-QFT- patients, compared to a more restricted pattern for TST+QFT+ patients. HBHA 126-130 interferon gamma Homo sapiens 90-99 34083537-4 2021 We now demonstrate that inflammatory mediators, including IFNgamma and polyIC, potentiate the cytotoxicity of phenformin by inducing a parallel increase in oxidative stress through STAT1-dependent mechanisms. Phenformin 110-120 interferon gamma Homo sapiens 58-66 34088327-8 2021 RESULTS: Lithium was shown to stimulate interferon-gamma (IFN-gamma) production as early as 3 h pi. Lithium 9-16 interferon gamma Homo sapiens 58-67 34173094-2 2021 Comparison of cytokine levels in psoriatic lesional skin and plasma samples of patients treated with apremilast or tofacitinib revealed statistical difference only for IFNgamma level (r<0.05) at week 26. tofacitinib 115-126 interferon gamma Homo sapiens 168-176 34190692-10 2021 DFP treatment significantly increases tumor protective immunity by decreasing the expression levels of TH2 network-specific GATA3 and interleukin 4 (IL4) genes but increasing the expression levels of TH1 network-specific IFNG, IL12, TBX21, and STAT1 genes. Isoflurophate 0-3 interferon gamma Homo sapiens 221-225 34072539-6 2021 The biotinylated-IFN-gamma was incorporated with colloidal-gold-labeled 6HIS-maltose binding protein-monomeric streptavidin (6HISMBP-mSA) and absorbed at the conjugate pad. 6his 72-76 interferon gamma Homo sapiens 17-26 34072539-6 2021 The biotinylated-IFN-gamma was incorporated with colloidal-gold-labeled 6HIS-maltose binding protein-monomeric streptavidin (6HISMBP-mSA) and absorbed at the conjugate pad. Maltose 77-84 interferon gamma Homo sapiens 17-26 34093551-7 2021 The pilot study showed that gluten peptides induced IL-2, IFN-gamma and IL-10 release from PBMCs attributable to CD4+ T cells, but the PBMC CRA was substantially less sensitive than whole blood CRA. Peptides 35-43 interferon gamma Homo sapiens 58-67 34277861-6 2021 IFN-gamma production in PBMC volunteers with CL and HCL stimulated with live or heat-killed L. major was significantly (p< 0.001) higher than in unstimulated ones. Hydrochloric Acid 52-55 interferon gamma Homo sapiens 0-9 34084198-9 2021 Meanwhile, treated cells with PCN G expressed decreased levels of IFN-gamma (difference = 8.0; 0.49-1.07; P = 0.001) and IL-17A (difference = 2.2; 0.05-0.75; P <= 0.05) genes comparing to unstimulated cell by PCN-G. GATA3 genes expression levels downregulated by PCN G after 72 h of incubation by PBMCs (difference = 1.1; 0.77-0.88; P = 0.035). Pregnenolone Carbonitrile 30-33 interferon gamma Homo sapiens 66-75 34084198-9 2021 Meanwhile, treated cells with PCN G expressed decreased levels of IFN-gamma (difference = 8.0; 0.49-1.07; P = 0.001) and IL-17A (difference = 2.2; 0.05-0.75; P <= 0.05) genes comparing to unstimulated cell by PCN-G. GATA3 genes expression levels downregulated by PCN G after 72 h of incubation by PBMCs (difference = 1.1; 0.77-0.88; P = 0.035). Pregnenolone Carbonitrile 263-266 interferon gamma Homo sapiens 66-75 34126236-9 2021 While phagocytic and bactericidal abilities of macrophages were not affected by FS treatment, healthy FS treated macrophages showed a greater ability to suppress CD4+ T cell activation and IFNgamma secretion compared to UC remission FS treated counterparts. phenylalanylserine 80-82 interferon gamma Homo sapiens 189-197 34269100-10 2021 In addition, SHR0302 decreased the expression of chemokine receptor CXCR3 on donor T cells and the secretion of cytokines or chemokines including interleukin (IL)-6, interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), CXCL10, etc. ivarmacitinib 13-20 interferon gamma Homo sapiens 166-193 35568074-6 2022 Interestingly, Anlotinib combined with PD-L1 blockade increased the infiltration of IFN-gamma+CD8+ T cells and natural killer (NK) cells, also decreased the quantity of Treg cells and MDSCs in vivo. anlotinib 15-24 interferon gamma Homo sapiens 84-93 34130465-0 2021 Changes in the co-expressions of interleukin 29 (IL-29), IFN-inducible protein 10 (IP-10) and monokine induced by IFNgamma (MIG) genes in chronic hepatitis C Egyptian patients untreated and treated with DAAs. daas 203-207 interferon gamma Homo sapiens 114-122 35537331-2 2022 We report that serial exposure of hippocampal slice cultures to IFN-gamma and lipopolysaccharide (Toll-like receptor 4 ligand) induces high release of IL-6, TNF-alpha and nitric oxide, concomitant loss of electrical network activity (neuronal gamma oscillations) and neurodegeneration. Nitric Oxide 171-183 interferon gamma Homo sapiens 64-73 34519584-6 2021 EV PD-L1 significantly inhibited the activation of human CD8+ T cells by down-regulating the cell surface CD69 expression and the intracellular IFNgamma and TNFalpha production in vitro. .alpha.-Glutamylvaline 0-2 interferon gamma Homo sapiens 144-152 35290881-5 2022 A dual-type Au microgap electrode was designed to measure TNF-alpha and IFN-gamma levels using a single biosensor. Gold 12-14 interferon gamma Homo sapiens 72-81 35580760-5 2022 Flow cytometric analysis of T cells following the treatment of primary human peripheral blood mononuclear cells with environmentally relevant concentrations of arsenic trioxide and subsequent challenge with influenza A virus showed reduced viability, alterations in activation, a reduction in the population of memory cells, and reduced effector function evidenced by IFNgamma and granzyme B production. Arsenic Trioxide 160-176 interferon gamma Homo sapiens 368-376 35429607-5 2022 Pre-treatment with folic acid, which has known neuroprotective and anti-inflammatory properties, ameliorated IL-6 effects on mitochondrial respiration and IFN-gamma effects on dendritic spine density. Folic Acid 19-29 interferon gamma Homo sapiens 155-164 35429607-6 2022 These findings suggest distinct mechanisms for how fetal IL-6 and IFN-gamma exposure influence risk for neuropsychiatric disorders, and how folic acid can mitigate such risk. Folic Acid 140-150 interferon gamma Homo sapiens 66-75 35306042-10 2022 RESULTS: Topical application of TFH significantly improved the severity of dermatitis by inhibiting the infiltration of mast cell, increasing expression of FLG, decreasing the expressions of TNF-alpha, IL-4, IFN-gamma and TSLP in skin lesions. tfh 32-35 interferon gamma Homo sapiens 208-217 35485195-2 2022 Awareness of the role of cytokines in SLE has led to new clinical perspectives in its pathogenesis; therefore, the aim of this study was to investigate the effect of vitamin 1, 25(OH) 2 D3 (D3) on the expression of IL-2, IL-4, IL-5, IL-10, and IFN-gamma cytokines in patients with lupus. vitamin 1, 25(oh) 2 d3 166-188 interferon gamma Homo sapiens 244-253 35485195-6 2022 RESULTS: It was observed that vitamin D3 reduced expression of IFN-gamma, IL-4, IL-5, and IL-10 genes by 73, 50, 37, and 29%, respectively, and increased IL-2 gene expression by 31% (p <= 0.05). Cholecalciferol 30-40 interferon gamma Homo sapiens 63-72 35306042-11 2022 TFH decreased the levels of IL-1alpha, IL-1beta, IL-6, monocyte chemoattractant protein (MCP)-1, MCP-3, macrophage-derived chemokine (MDC), platelet-derived growth factor (PDGF)-BB, thymus and activation regulated chemokine (TARC) in the supernatants of the HaCaT cells treated by IFN-gamma/TNF-alpha. tfh 0-3 interferon gamma Homo sapiens 281-290 35306042-12 2022 Furthermore, expressions of p-NF-kappaB, p-ERK and p-P38 were also decreased by TFH administration with dose dependent manner in HaCaT cells treated by IFN-gamma/TNF-alpha. tfh 80-83 interferon gamma Homo sapiens 152-161 35580406-10 2022 GSEA revealed prominent activation of IFN-related signaling pathways in CIUE placenta, particularly IFNgamma signaling. gsea 0-4 interferon gamma Homo sapiens 100-108 35523178-3 2022 Both IFN-gamma and iron treatment increased labile iron levels, but only iron treatment led to a consistent increase of ferritin levels, reflecting long-term iron storage. Iron 51-55 interferon gamma Homo sapiens 5-14 35307400-2 2022 Neopterin (NPT), produced by macrophages when stimulated with interferon (IFN-)gamma, is an essential cytokine in the antiviral immune response. Neopterin 0-9 interferon gamma Homo sapiens 74-84 35307400-2 2022 Neopterin (NPT), produced by macrophages when stimulated with interferon (IFN-)gamma, is an essential cytokine in the antiviral immune response. Neopterin 11-14 interferon gamma Homo sapiens 74-84 35297512-0 2022 Suppression of IL-12/IL-23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon-gamma signaling in dendritic cells: Implications for the treatment of psoriasis and interferon-driven diseases. tofacitinib 86-97 interferon gamma Homo sapiens 121-137 35307819-6 2022 Mechanistically, we demonstrated that a deficiency on galactose structures on IgG Fc in COVID-19 patients appears to induce NK cells activation associated with increased release of IFNgamma and TNFalpha, which indicates the presence of pro-inflammatory immunoglobulins and higher immune activation, associated with a poor disease course. Galactose 54-63 interferon gamma Homo sapiens 181-189 35167033-0 2022 Identification of nafamostat mesylate as a selective stimulator of NK cell IFN-gamma production via metabolism-related compound library screening. nafamostat 18-37 interferon gamma Homo sapiens 75-84 35297512-6 2022 Our results indicate that in DCs co-stimulated with LPS and IFN-gamma, but not with LPS alone, Tofacitinib leads to the decreased expression of IL-23/IL-12 shared subunit IL12B (p40). tofacitinib 95-106 interferon gamma Homo sapiens 60-69 35297512-7 2022 In Tofacitinib-treated Pso patients, IL-12 expression and psoriasis area and severity index (PASI) are significantly reduced in patients with higher IFN-gamma at baseline. tofacitinib 3-14 interferon gamma Homo sapiens 149-158 35297512-8 2022 These findings demonstrate for the first time that Tofacitinib suppresses IL-23/IL-12 shared subunit IL12B in DCs upon active IFN-gamma signaling, and that Pso patients with higher IFN-gamma baseline levels display improved clinical response after Tofacitinib treatment. tofacitinib 51-62 interferon gamma Homo sapiens 126-135 35297512-8 2022 These findings demonstrate for the first time that Tofacitinib suppresses IL-23/IL-12 shared subunit IL12B in DCs upon active IFN-gamma signaling, and that Pso patients with higher IFN-gamma baseline levels display improved clinical response after Tofacitinib treatment. tofacitinib 51-62 interferon gamma Homo sapiens 181-190 34996851-7 2022 Preinhaled IFN-gamma (100 microg/mL) increased the capsaicin cough sensitivity in CRC patients but not healthy volunteers. Capsaicin 51-60 interferon gamma Homo sapiens 11-20 35219165-9 2022 In vitro experiment demonstrated PR-957 also reversed IFN-gamma-induced upregulation of MHC-II in endothelial cells. PR-957 33-39 interferon gamma Homo sapiens 54-63 35435623-8 2022 RESULTS: Patients with moderate to severe cancer pain taking oxycodone had significantly higher levels of IL-2, IL-4, IL-6, IL-10, TNF-alpha, and IFN-gamma than those in the control group (p < 0.001). Oxycodone 61-70 interferon gamma Homo sapiens 146-155 35339753-6 2022 LPS + IFNgamma stimuli reduced superoxide anion levels by accelerating its conversion into hydrogen peroxide (H2O2) while IL4+IL13 decreased H2O2 release rates. Superoxides 31-47 interferon gamma Homo sapiens 6-14 35339753-6 2022 LPS + IFNgamma stimuli reduced superoxide anion levels by accelerating its conversion into hydrogen peroxide (H2O2) while IL4+IL13 decreased H2O2 release rates. Hydrogen Peroxide 91-108 interferon gamma Homo sapiens 6-14 35339753-6 2022 LPS + IFNgamma stimuli reduced superoxide anion levels by accelerating its conversion into hydrogen peroxide (H2O2) while IL4+IL13 decreased H2O2 release rates. Hydrogen Peroxide 110-114 interferon gamma Homo sapiens 6-14 35611390-9 2022 Cytokines measured in the media with Luminex methodology indicated decreased PBMC secretion of IFN-gamma by PFOA and PFOS in medium with serum, but no alteration in OpSFM. perfluorooctanoic acid 108-112 interferon gamma Homo sapiens 95-104 35636577-7 2022 However, improved proliferation and interferon-gamma production of HEV-specific CD8+ T cells and evolution of a memory-like phenotype was observed upon reduction of immunosuppression and/or ribavirin treatment and was associated with viral clearance. Ribavirin 190-199 interferon gamma Homo sapiens 36-52 35619558-5 2022 Although perioperative arginine did not prevent immediate NK cell immunoparalysis after surgery, it did accelerate their return to preoperative cytotoxicity, IFN-gamma secretion, and activating receptor expression. Arginine 23-31 interferon gamma Homo sapiens 158-167 35611390-9 2022 Cytokines measured in the media with Luminex methodology indicated decreased PBMC secretion of IFN-gamma by PFOA and PFOS in medium with serum, but no alteration in OpSFM. perfluorooctane sulfonic acid 117-121 interferon gamma Homo sapiens 95-104 35134851-10 2022 Sulprostone intensified the mRNA levels of IL-6 together with interferon-gamma (IFN-gamma), while L-798,106 stimulated the mRNA expression of IL-10 and Arg-1 in a dose-dependent manner. sulprostone 0-11 interferon gamma Homo sapiens 62-78 35134851-10 2022 Sulprostone intensified the mRNA levels of IL-6 together with interferon-gamma (IFN-gamma), while L-798,106 stimulated the mRNA expression of IL-10 and Arg-1 in a dose-dependent manner. sulprostone 0-11 interferon gamma Homo sapiens 80-89 35631163-7 2022 EGb decreased production of TNF-alpha, IFN-gamma, and IL-10 and increased IL-15 and IL-1beta. BDBM50323769 0-3 interferon gamma Homo sapiens 39-48 35630678-8 2022 MCP-1 and ICAM-1 expression levels in THP-1 macrophages treated with 50 microg/mL fucoidan for 24 h, followed by induction by IFN-gamma, were shown to be significantly suppressed as eight- and four-fold changes, respectively, relative to cells treated only with IFN-gamma. fucoidan 82-90 interferon gamma Homo sapiens 262-271 35560224-9 2022 Treatment with LY2109761 increased IFN-gamma expression in CD8+ T cells and reduced the number of regulatory T cells in the tumor microenvironment. LY2109761 15-24 interferon gamma Homo sapiens 35-44 35553638-9 2022 Significant negative correlations between SA GCR expression and IFNgamma/TNFalpha production by T and NKT-like cells (eg, T-cell IFNgamma R = -0.834, P = 0.031) and with FEV1 (R = -0.890) were shown. sa 42-44 interferon gamma Homo sapiens 64-72 35553638-9 2022 Significant negative correlations between SA GCR expression and IFNgamma/TNFalpha production by T and NKT-like cells (eg, T-cell IFNgamma R = -0.834, P = 0.031) and with FEV1 (R = -0.890) were shown. sa 42-44 interferon gamma Homo sapiens 129-137 35625855-10 2022 In PBMC/RASF co-culture, THC decreased TNF production when cells were stimulated with interferon-gamma (IFN-gamma) or CpG. Dronabinol 25-28 interferon gamma Homo sapiens 86-102 35625855-10 2022 In PBMC/RASF co-culture, THC decreased TNF production when cells were stimulated with interferon-gamma (IFN-gamma) or CpG. Dronabinol 25-28 interferon gamma Homo sapiens 104-113 35634282-9 2022 The combination of 5-FU with ICB augmented an inflammatory tumor microenvironment with markedly increased CD8+ T cell activation and upregulation of IFNgamma, TNFalpha and IL-1beta signaling. Fluorouracil 19-23 interferon gamma Homo sapiens 149-157 35536531-4 2022 Tofacitinib significantly inhibited expression of pro-inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), vascular endothelial growth factor A, matrix metalloproteinase 1, matrix metalloproteinase 3, interleukin-6 and interferon gamma in RA-FLS cells. tofacitinib 0-11 interferon gamma Homo sapiens 238-254 35579155-5 2022 Meantime, immune cells release immunostimulatory cytokines including TNF-alpha and IFN-gamma to downregulate the expression of SLC7A11 and SLC3A2, and reduce the absorption of cysteine, leading to lipid peroxidation and iron deposition in cancer cells. Cysteine 176-184 interferon gamma Homo sapiens 83-92 35538539-8 2022 RESULTS: Our results show that both tanimilast and budesonide reduced the production of the immunostimulatory cytokine IFN-gamma by CD4+ T cells. Budesonide 51-61 interferon gamma Homo sapiens 119-128 35534947-8 2022 RNA-sequencing analysis showed that Dox treatment predominantly targets cell cycle and attachment of microtubules and boosted tumour necrosis, chemokine and interferon-gamma production, response to cytokine and chemokine, and T cell activation, whereas Rh2 regulated these effects. Doxorubicin 36-39 interferon gamma Homo sapiens 157-173 35625832-9 2022 IFNgamma-treated U937 activated the EMT process and WNT pathway in HT29 cells, and the EMT process is mediated by FZD4. N-(Chloroacetyl)allylamine 17-21 interferon gamma Homo sapiens 0-8 35579155-5 2022 Meantime, immune cells release immunostimulatory cytokines including TNF-alpha and IFN-gamma to downregulate the expression of SLC7A11 and SLC3A2, and reduce the absorption of cysteine, leading to lipid peroxidation and iron deposition in cancer cells. Iron 220-224 interferon gamma Homo sapiens 83-92 35510301-0 2022 Extracellular adenosine triphosphate induces IDO and IFNgamma expression of human periodontal ligament cells through P2 X7 receptor signaling. Adenosine 14-23 interferon gamma Homo sapiens 53-61 35507102-7 2022 In addition, OVCAR4 was found to be carboplatin sensitive before and after treatment with IFN-gamma and NK cell supernatants, whereas OVCAR8 remained carboplatin resistant with and without treatment with IFN-gamma and NK cell supernatants. Carboplatin 36-47 interferon gamma Homo sapiens 90-99 35507102-7 2022 In addition, OVCAR4 was found to be carboplatin sensitive before and after treatment with IFN-gamma and NK cell supernatants, whereas OVCAR8 remained carboplatin resistant with and without treatment with IFN-gamma and NK cell supernatants. Carboplatin 150-161 interferon gamma Homo sapiens 204-213 35510301-3 2022 eATP involves in immunosuppressive action by increasing immunosuppressive molecules IDO and IFNgamma expression on immune cells. eatp 0-4 interferon gamma Homo sapiens 92-100 35510301-11 2022 Moreover, eATP increased kynurenine which is the active metabolite of tryptophan breakdown catalyzed by the IDO enzyme and significantly induced IFNgamma protein expression. Kynurenine 25-35 interferon gamma Homo sapiens 145-153 35510301-11 2022 Moreover, eATP increased kynurenine which is the active metabolite of tryptophan breakdown catalyzed by the IDO enzyme and significantly induced IFNgamma protein expression. Tryptophan 70-80 interferon gamma Homo sapiens 145-153 35218793-0 2022 Lower antidepressant response to fluoxetine is associated with anxiety-like behavior, hippocampal oxidative imbalance, and increase on peripheral IL-17 and IFN-gamma levels. Fluoxetine 33-43 interferon gamma Homo sapiens 156-165 35510301-12 2022 EGTA and PKCi reduced eATP-induced IDO and IFNgamma expressions by hPDLCs, confirming the role of calcium signaling. Egtazic Acid 0-4 interferon gamma Homo sapiens 43-51 35510301-12 2022 EGTA and PKCi reduced eATP-induced IDO and IFNgamma expressions by hPDLCs, confirming the role of calcium signaling. eatp 22-26 interferon gamma Homo sapiens 43-51 35510301-12 2022 EGTA and PKCi reduced eATP-induced IDO and IFNgamma expressions by hPDLCs, confirming the role of calcium signaling. Calcium 98-105 interferon gamma Homo sapiens 43-51 35510301-13 2022 Chemical P2 X7 inhibitors (KN62 and BBG) and siRNA targeting the P2 X7 receptor significantly inhibited the eATP-induced IDO and IFNgamma production. KN 62 27-31 interferon gamma Homo sapiens 129-137 35510301-13 2022 Chemical P2 X7 inhibitors (KN62 and BBG) and siRNA targeting the P2 X7 receptor significantly inhibited the eATP-induced IDO and IFNgamma production. coomassie Brilliant Blue 36-39 interferon gamma Homo sapiens 129-137 35510301-14 2022 Correspondingly, BzATP markedly increased IDO and IFNgamma expression. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 17-22 interferon gamma Homo sapiens 50-58 35510301-15 2022 CONCLUSION: eATP induced immunosuppressive function of hPDLCs by promoting IDO and IFNgamma production via P2 X7 receptor signaling. eatp 12-16 interferon gamma Homo sapiens 83-91 35535217-5 2022 In addition, vitamin D can also inhibit the secretion of T-helper type 1 (Th1) cytokines IFN-Y and IL-2 while stimulating the production of Th2 cytokines, thereby promoting wound healing. Vitamin D 13-22 interferon gamma Homo sapiens 89-94 35503721-5 2022 Mechanistically, we discovered that treatment with the genotoxic agent etoposide led to the transcriptional reprogramming of multiple pro-inflammatory cytokines, among which the interferon-alpha and interferon-gamma responses were substantially enriched in resistant cells. Etoposide 71-80 interferon gamma Homo sapiens 199-215 35503786-7 2022 Prior to starting ivermectin treatment, OvAg-induced cellular productions of IL-10, IFN-gamma, CCL13, CCL17 and CCL18 were low in patients, and at 30yPT, cellular cytokine and chemokine responses increased to the levels observed in endemic controls. ovag 40-44 interferon gamma Homo sapiens 84-93 35500221-7 2022 Interestingly, inhibition of NAMPT in healthy monocytes completely abrogated the IFNgamma-induced oxygen consumption, comparable to levels observed in CGD monocytes. Oxygen 98-104 interferon gamma Homo sapiens 81-89 35500221-0 2022 IFNgamma Regulates NAD+ Metabolism to Promote the Respiratory Burst in Human Monocytes. NAD 19-23 interferon gamma Homo sapiens 0-8 35500221-8 2022 These data identify an IFNgamma-induced, NAMPT-dependent, NAD+ salvage pathway that is critical for IFNgamma activation of human monocytes. NAD 58-62 interferon gamma Homo sapiens 23-31 35500221-3 2022 We found that IFNgamma increased oxygen consumption rates (OCR) in monocytes, indicative of reactive oxygen species generation by both mitochondria and NADPH oxidase. Oxygen 33-39 interferon gamma Homo sapiens 14-22 35500221-3 2022 We found that IFNgamma increased oxygen consumption rates (OCR) in monocytes, indicative of reactive oxygen species generation by both mitochondria and NADPH oxidase. Oxygen 101-107 interferon gamma Homo sapiens 14-22 35500221-4 2022 Transcriptional profiling revealed that this oxidative phenotype was driven by IFNgamma-induced reprogramming of NAD+ metabolism, which is dependent on nicotinamide phosphoribosyltransferase (NAMPT)-mediated NAD+ salvage to generate NADH and NADPH for oxidation by mitochondrial complex I and NADPH oxidase, respectively. NAD 113-117 interferon gamma Homo sapiens 79-87 35500221-4 2022 Transcriptional profiling revealed that this oxidative phenotype was driven by IFNgamma-induced reprogramming of NAD+ metabolism, which is dependent on nicotinamide phosphoribosyltransferase (NAMPT)-mediated NAD+ salvage to generate NADH and NADPH for oxidation by mitochondrial complex I and NADPH oxidase, respectively. NAD 208-212 interferon gamma Homo sapiens 79-87 35500221-4 2022 Transcriptional profiling revealed that this oxidative phenotype was driven by IFNgamma-induced reprogramming of NAD+ metabolism, which is dependent on nicotinamide phosphoribosyltransferase (NAMPT)-mediated NAD+ salvage to generate NADH and NADPH for oxidation by mitochondrial complex I and NADPH oxidase, respectively. NAD 233-237 interferon gamma Homo sapiens 79-87 35500221-8 2022 These data identify an IFNgamma-induced, NAMPT-dependent, NAD+ salvage pathway that is critical for IFNgamma activation of human monocytes. NAD 58-62 interferon gamma Homo sapiens 100-108 35131452-12 2022 IFN-gamma and TMB further differentiate outcomes for patients treated with atezolizumab, vemurafenib, and cobimetinib. Vemurafenib 89-100 interferon gamma Homo sapiens 0-9 35131452-12 2022 IFN-gamma and TMB further differentiate outcomes for patients treated with atezolizumab, vemurafenib, and cobimetinib. cobimetinib 106-117 interferon gamma Homo sapiens 0-9 35124342-0 2022 Target-induced silver nanocluster generation for highly sensitive electrochemical aptasensor towards cell-secreted interferon-gamma. Silver 15-21 interferon gamma Homo sapiens 115-131 35124342-2 2022 This work addresses the development of a sensitive and specific electrochemical assay for detection of IFN-gamma by combing the recognition unit of aptamer with the signal reporter of target-induced silver nanoclusters (AgNCs). Silver 199-205 interferon gamma Homo sapiens 103-112 35580926-12 2022 We find that A2BAR antagonists rescue T and NK cell proliferation, IFNgamma and perforin production, and increase tumor infiltrating lymphocytes infiltration into tumor spheroids without altering the expression of adhesion molecules. a2bar 13-18 interferon gamma Homo sapiens 67-75 35606087-9 2022 AG-881 monotherapy suppressed the progression of IDH1R132H gliomas in a CD4+ and CD8+ cell-dependent manner, enhanced proinflammatory IFNgamma-related gene expression, and increased the number of CD4+ tumor-infiltrating T-cells. Vorasidenib 0-6 interferon gamma Homo sapiens 134-142 35562484-0 2022 IFNgamma regulates ferroptosis with fatty acids. Fatty Acids 36-47 interferon gamma Homo sapiens 0-8 35322867-3 2022 Recent evidence suggests that IFNgamma facilitates erastin-induced ferroptosis, which contributed to anticancer therapy in various types of cancer. erastin 51-58 interferon gamma Homo sapiens 30-38 35322867-5 2022 Thus, the aim of the present study was to explore the effects of IFNgamma on erastin-induced ferroptosis in the ACC cell line NCI-H295R and investigate the underlying mechanisms. erastin 77-84 interferon gamma Homo sapiens 65-73 35322867-9 2022 The results suggested that IFNgamma promoted erastin-induced ferroptotic cell death. erastin 45-52 interferon gamma Homo sapiens 27-35 35322867-10 2022 Furthermore, IFNgamma enhanced erastin-induced ferroptosis, as evidenced by the accumulation of iron, as well as the increase in lipid peroxidation and promotion of mitochondrial damage. erastin 31-38 interferon gamma Homo sapiens 13-21 35322867-10 2022 Furthermore, IFNgamma enhanced erastin-induced ferroptosis, as evidenced by the accumulation of iron, as well as the increase in lipid peroxidation and promotion of mitochondrial damage. Iron 96-100 interferon gamma Homo sapiens 13-21 35528166-0 2022 Corrigendum to "Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma". baicalin 24-32 interferon gamma Homo sapiens 82-92 35266648-3 2022 Inhibition of IFNG pathway by the JAK1/2 inhibitor ruxolitinib or knocking out Stat1 gene abrogated the IFNG-induced melanogenesis. ruxolitinib 51-62 interferon gamma Homo sapiens 14-18 35266648-8 2022 Moreover, cycloheximide chase assay showed that degradation of TYR was decreased in IFNG-treated cells. Cycloheximide 10-23 interferon gamma Homo sapiens 84-88 35529932-6 2022 S-1 therapy plus apatinib outperformed the single therapy of S-1 therapy in mitigating the levels of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4), and interleukin-10 (IL-10) (P < 0.05). apatinib 17-25 interferon gamma Homo sapiens 101-117 35529932-6 2022 S-1 therapy plus apatinib outperformed the single therapy of S-1 therapy in mitigating the levels of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4), and interleukin-10 (IL-10) (P < 0.05). apatinib 17-25 interferon gamma Homo sapiens 119-128 35234509-1 2022 QuantiFERON-TB Gold Plus (QFT-Plus) is an emerging QuantiFERON test after QuantiFERON-TB Gold In-Tube (QFT-GIT) for tuberculosis infection detection; it is an IFN-gamma release assay. -tb gold 11-19 interferon gamma Homo sapiens 159-168 35234509-1 2022 QuantiFERON-TB Gold Plus (QFT-Plus) is an emerging QuantiFERON test after QuantiFERON-TB Gold In-Tube (QFT-GIT) for tuberculosis infection detection; it is an IFN-gamma release assay. -tb gold 85-93 interferon gamma Homo sapiens 159-168 35563767-8 2022 The active metabolite 1alpha,25(OH)2D3 inhibited the in vitro activation of gammadelta T cells at the level of proliferation, cytotoxicity, and interferon-gamma production. Calcitriol 22-38 interferon gamma Homo sapiens 144-160 35483526-8 2022 High numbers of non-HLA-binding transitional cells associated with B-suppressed interferon-gamma production, especially if Tregs were present. tregs 123-128 interferon gamma Homo sapiens 80-96 35471556-0 2022 Mulberry vinegar attenuates lipopolysaccharide and interferon gamma-induced inflammatory responses in C6 glial cells. mulberry vinegar 0-16 interferon gamma Homo sapiens 51-67 35471556-2 2022 Treatment with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) induced the nitric oxide and reactive oxygen species generation, while pre-incubation with MV inhibited these formations in a concentration-dependent manner. Nitric Oxide 85-97 interferon gamma Homo sapiens 44-60 35471556-2 2022 Treatment with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) induced the nitric oxide and reactive oxygen species generation, while pre-incubation with MV inhibited these formations in a concentration-dependent manner. Nitric Oxide 85-97 interferon gamma Homo sapiens 62-71 35471556-2 2022 Treatment with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) induced the nitric oxide and reactive oxygen species generation, while pre-incubation with MV inhibited these formations in a concentration-dependent manner. Reactive Oxygen Species 102-125 interferon gamma Homo sapiens 44-60 35471556-2 2022 Treatment with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) induced the nitric oxide and reactive oxygen species generation, while pre-incubation with MV inhibited these formations in a concentration-dependent manner. Reactive Oxygen Species 102-125 interferon gamma Homo sapiens 62-71 35471556-2 2022 Treatment with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) induced the nitric oxide and reactive oxygen species generation, while pre-incubation with MV inhibited these formations in a concentration-dependent manner. mv 164-166 interferon gamma Homo sapiens 44-60 35471556-2 2022 Treatment with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) induced the nitric oxide and reactive oxygen species generation, while pre-incubation with MV inhibited these formations in a concentration-dependent manner. mv 164-166 interferon gamma Homo sapiens 62-71 35471556-3 2022 MV treatment also decreased the production of pro-inflammatory cytokines, such as interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha in C6 glial cells stimulated by LPS/IFN-gamma. mv 0-2 interferon gamma Homo sapiens 186-195 35471556-4 2022 Compared to the LPS/IFN-gamma-treated control group, the MV-treated group exerts downregulation in the protein expressions of inducible nitric oxide synthase and cyclooxygenase-2, through inhibition of nuclear factor-kappaB activation. Nitric Oxide 136-148 interferon gamma Homo sapiens 20-29 35529881-6 2022 Serum IFN-gamma and IL-6 levels were decreased in steroid-treated patients when compared to non-steroid treated patients. Steroids 50-57 interferon gamma Homo sapiens 6-15 35529881-6 2022 Serum IFN-gamma and IL-6 levels were decreased in steroid-treated patients when compared to non-steroid treated patients. Steroids 96-103 interferon gamma Homo sapiens 6-15 35446871-3 2022 A sub-type of MSCs referred to as "marrow-isolated adult multilineage inducible" (MIAMI) cells, which were isolated from bone marrow, were utilized to show that the addition of autophagy modulators, tamoxifen (TX) or chloroquine (CQ), can alter how MIAMI cells respond to IFNgamma exposure in vitro resulting in an increased immunoregulatory capacity of the MIAMI cells. Tamoxifen 199-208 interferon gamma Homo sapiens 272-280 35446871-8 2022 Data analysis revealed 693 long intergenic non-coding RNAS (lincRNAs), 480 pseudogenes, and 642 antisense RNAs that were differentially regulated with IFNgamma, IFNgamma+TX and IFNgamma+CQ treatments. Chloroquine 186-188 interferon gamma Homo sapiens 177-185 35492074-10 2022 The in vitro results demonstrated that the combination of morphine and ketamine may decrease CD4+ percentage, CD4+/CD8+ ratio, and the levels of IFN-gamma, IL-2, and IL-17 via the JAK3/STAT5 pathway. Morphine 58-66 interferon gamma Homo sapiens 145-154 35492074-10 2022 The in vitro results demonstrated that the combination of morphine and ketamine may decrease CD4+ percentage, CD4+/CD8+ ratio, and the levels of IFN-gamma, IL-2, and IL-17 via the JAK3/STAT5 pathway. Ketamine 71-79 interferon gamma Homo sapiens 145-154 35483526-9 2022 However, high frequencies of HLA-binding marginal-zone precursors associated with B-dependent interferon-gamma production that appeared suppressible by Tregs. tregs 152-157 interferon gamma Homo sapiens 94-110 35483526-10 2022 Finally, non-HLA-binding marginal zone precursors may also suppress interferon-gamma production, though this association only emerged when Tregs were absent from the ELISpot. tregs 139-144 interferon gamma Homo sapiens 68-84 35460727-9 2022 Increased uric acid levels were positively correlated with mucosal neutrophil numbers and IFN-gamma, IL-17A, IL-1beta, and IL-8 mRNA levels. Uric Acid 10-19 interferon gamma Homo sapiens 90-99 35437772-15 2022 On the other hand, ratio of the effector T cells increased along with greater IFN-gamma activation after BNT booster. BNT 105-108 interferon gamma Homo sapiens 78-87 35563682-8 2022 Rapa-pretreated cells, but not 3-MA-pretreated cells, further amplified COX2 and IL-6 transcripts following IFNgamma exposure, and both groups upregulated secretion of prostaglandin-E2 (PGE2), the enzymatic product of COX2. Sirolimus 0-4 interferon gamma Homo sapiens 108-116 35565961-10 2022 The release of pro-inflammatory cytokines induced by treatment of TNF-alpha/IFN-gamma was reduced after pretreatment with cycloheterophyllin. cycloheterophyllin 122-140 interferon gamma Homo sapiens 76-85 35493463-8 2022 TRP score was positively associated with malignant pathways in pan-cancer, such as IL6-JAK-STAT3 signalling, interferon-gamma response, and inflammatory response. Tryptophan 0-3 interferon gamma Homo sapiens 109-125 35355022-11 2022 Pre-treatment of orobol decreased the activity of the MAPKs and NF-kappaB signalling cascade in the TNFalpha/IFNgamma-induced HaCaT cell line. orobol 17-23 interferon gamma Homo sapiens 109-117 35455080-0 2022 Euphorbia hirta Leaf Ethanol Extract Suppresses TNF-alpha/IFN-gamma-Induced Inflammatory Response via Down-Regulating JNK or STAT1/3 Pathways in Human Keratinocytes. Ethanol 21-28 interferon gamma Homo sapiens 58-67 35514988-9 2022 LPE decreased the serum levels of antibodies, immunoglobulins, and complements 4 weeks after the first replacement, with decreased levels of interleukin (IL)-17A and interferon (IFN)-gamma and increased level of IL-10. LPC-ETHER 0-3 interferon gamma Homo sapiens 166-188 35216678-8 2022 Thus, IFNgamma signaling paired with selective fatty acids is a natural tumor ferroptosis-promoting mechanism and a mode of action of CTLs. Fatty Acids 47-58 interferon gamma Homo sapiens 6-14 35409339-6 2022 All SCFAs dose-dependently inhibited CXCL10 release of the cells after activation with IFN-gamma or IFN-gamma+TNF-alpha. Fatty Acids, Volatile 4-9 interferon gamma Homo sapiens 87-96 35216678-3 2022 Mechanistically, IFNgamma stimulates ACSL4 and alters tumor cell lipid pattern, thereby increasing incorporations of AA into C16 and C18 acyl chain-containing phospholipids. Phospholipids 159-172 interferon gamma Homo sapiens 17-25 35396684-6 2022 We suggest that by selectively constraining the production of PGE2 during vaccination or therapy of susceptible persons or infected patients of schistosomiasis, this would boost IL-12 and reduce IL-10 production leading to a polarization toward the anti-worm Thl cytokine synthesis (IL-2 and Interferon (IFN)-gamma). Dinoprostone 62-66 interferon gamma Homo sapiens 292-314 35409339-6 2022 All SCFAs dose-dependently inhibited CXCL10 release of the cells after activation with IFN-gamma or IFN-gamma+TNF-alpha. Fatty Acids, Volatile 4-9 interferon gamma Homo sapiens 100-109 35166455-0 2022 Identification of a New Cholesterol-Binding Site within the IFN-gamma Receptor that is Required for Signal Transduction. Cholesterol 24-35 interferon gamma Homo sapiens 60-69 35000080-9 2022 Moreover, TAM infiltration was negatively associated with IFN-gamma-related mRNA panel, which was shown to have strong predictive value for clinical response to programmed death-1 (PD-1) inhibition. tam 10-13 interferon gamma Homo sapiens 58-67 35362047-0 2022 IFNgamma Helps CBLB-Deficient CD8+ T Cells to Put Up Resistance to Tregs. tregs 67-72 interferon gamma Homo sapiens 0-8 35464376-8 2022 Results indicated an enhancing effect of PA on IgM, interleukins 2 and 4, interferon-gamma, and IgG subclass responses. Protactinium 41-43 interferon gamma Homo sapiens 74-90 35217429-6 2022 Sperm exposed to different concentrations of IFNgamma, IL-17A and IL-1beta, or a combination of them, for either 1 or 3 h showed significantly increased levels of mitochondrial ROS production and reduced motility and viability with respect to sperm incubated with vehicle. ros 177-180 interferon gamma Homo sapiens 45-53 35217429-9 2022 In conclusion, our results indicate that IFNgamma, IL-17A and IL-1beta per se impair sperm motility and decreases viability by triggering increased mitochondrial ROS production and inducing sperm apoptosis. ros 162-165 interferon gamma Homo sapiens 41-49 35121268-4 2022 Among CoV2+, we only observed significant differences after the first dose in both qAbs and IFNgamma+ T cells. cov2+ 6-11 interferon gamma Homo sapiens 92-100 35432354-2 2022 Of note, TB-IRIS is characterized by exacerbated inflammation and tissue damage that occurs in response to the elevated production of CD4+ T cell-derived IFN-gamma. Terbium 9-11 interferon gamma Homo sapiens 154-163 35151653-6 2022 FhTeg binds to and modulates cytokine production in human PBMCs, in particular targeting the CD4+ population resulting in reduced levels of TNF, IL-2 and IFNgamma and increased markers of anergy. fhteg 0-5 interferon gamma Homo sapiens 154-162 35438620-4 2022 IFNgamma stimulation induced a significant increase in endogenous A3G expression and cccDNA hypermutation. cccdna 85-91 interferon gamma Homo sapiens 0-8 35433496-2 2022 Both ATP-dependent chromatin remodeling complex and histone modifications has been shown to be involved in the activation of IFNgamma responsive genes. Adenosine Triphosphate 5-8 interferon gamma Homo sapiens 125-133 35014010-9 2022 Baricitinib inhibited IFNgamma-induced STAT1 phosphorylation, while JAK/STAT activation played a pivotal role in IFNgamma-mediated GLS/TP upregulation in RA. baricitinib 0-11 interferon gamma Homo sapiens 22-30 35014010-10 2022 These results suggested that baricitinib suppressed IFNgamma-induced GLS/TP expression by inhibiting JAK/STAT signaling, resulting in the attenuation of neovascularization, synovial inflammation, and cartilage destruction. baricitinib 29-40 interferon gamma Homo sapiens 52-60 35063658-0 2022 Vitamin D3 and zinc synergistically induce regulatory T cells and suppress interferon-gamma production in mixed lymphocyte culture. Cholecalciferol 0-10 interferon gamma Homo sapiens 75-91 35417322-9 2022 Using curcumin-loaded niosomes decreased immune cell influx and the inflammatory mediators (MIP-1alpha, TNF-alpha and IFN-gamma) production in the lung, resulting in alleviated lung pathology following RSV infection. Curcumin 6-14 interferon gamma Homo sapiens 118-127 35063658-4 2022 In mixed lymphocyte culture (MLC), therapeutic concentrations of vitamin D3 and zinc in combination suppressed interferon-gamma (IFN-gamma) secretion more strongly than the single agent treatment. Cholecalciferol 65-75 interferon gamma Homo sapiens 111-127 35063658-4 2022 In mixed lymphocyte culture (MLC), therapeutic concentrations of vitamin D3 and zinc in combination suppressed interferon-gamma (IFN-gamma) secretion more strongly than the single agent treatment. Cholecalciferol 65-75 interferon gamma Homo sapiens 129-138 35194944-8 2022 In a syngeneic CRC model, DCZ0415 treatment induced an immune response by decreasing PD1 and CTLA4 levels and increasing granzyme B, perforin and interferon gamma. DCZ0415 26-33 interferon gamma Homo sapiens 146-162 35452300-3 2022 Methods: Using an in vitro cell culture system, isolated cells were activated and treated with red or near-infrared light wavelengths to determine the effect of PBM on the production of interferon gamma and interleukin-10 (IL-10). pbm 161-164 interferon gamma Homo sapiens 186-202 35123188-4 2022 The effect of various doses of dexamethasone on cell proliferation, survival, surface markers, IFN-gamma production, and antitumor effects in antigen-specific T cells was examined in vitro. Dexamethasone 31-44 interferon gamma Homo sapiens 95-104 35422810-7 2022 Co-expression network analysis showed that 13 urinary microbial metabolites (e.g., oxoglutaric acid) were significantly correlated with alterations of CD4+, CD3+, and CD8+ T-cells, as well as IFN-gamma, IL-2 and IL-4 levels, suggesting close interactions between microbial metabolites and host immune dysregulation in COVID-19. Ketoglutaric Acids 83-99 interferon gamma Homo sapiens 192-201 35414258-5 2022 Given that aldehydes are made as parts of metabolic programmes that accompany immune cell activation by the cytokine interferon-gamma (IFN-gamma) during infections, we hypothesize that aldehydes are among the arsenal of IFN-gamma-inducible effectors needed for pathogen control. Aldehydes 11-20 interferon gamma Homo sapiens 117-133 35414258-5 2022 Given that aldehydes are made as parts of metabolic programmes that accompany immune cell activation by the cytokine interferon-gamma (IFN-gamma) during infections, we hypothesize that aldehydes are among the arsenal of IFN-gamma-inducible effectors needed for pathogen control. Aldehydes 11-20 interferon gamma Homo sapiens 135-144 35414258-5 2022 Given that aldehydes are made as parts of metabolic programmes that accompany immune cell activation by the cytokine interferon-gamma (IFN-gamma) during infections, we hypothesize that aldehydes are among the arsenal of IFN-gamma-inducible effectors needed for pathogen control. Aldehydes 11-20 interferon gamma Homo sapiens 220-229 35414258-5 2022 Given that aldehydes are made as parts of metabolic programmes that accompany immune cell activation by the cytokine interferon-gamma (IFN-gamma) during infections, we hypothesize that aldehydes are among the arsenal of IFN-gamma-inducible effectors needed for pathogen control. Aldehydes 185-194 interferon gamma Homo sapiens 117-133 35414258-5 2022 Given that aldehydes are made as parts of metabolic programmes that accompany immune cell activation by the cytokine interferon-gamma (IFN-gamma) during infections, we hypothesize that aldehydes are among the arsenal of IFN-gamma-inducible effectors needed for pathogen control. Aldehydes 185-194 interferon gamma Homo sapiens 135-144 35414258-5 2022 Given that aldehydes are made as parts of metabolic programmes that accompany immune cell activation by the cytokine interferon-gamma (IFN-gamma) during infections, we hypothesize that aldehydes are among the arsenal of IFN-gamma-inducible effectors needed for pathogen control. Aldehydes 185-194 interferon gamma Homo sapiens 220-229 35349767-7 2022 Furin or TGFbeta1 knockdown in Tregs promoted Teff cell proliferation, stimulated IL-2 and IFN-gamma secretion, and inhibited HBV replication/gene expression in the co-culture system of Teff, Treg, and HBV1.3P-HepG2 cells. tregs 31-36 interferon gamma Homo sapiens 91-100 35349670-3 2022 Here, we addressed the effect of IFN-gamma released by AML cells in BM Tregs induction and its impact on AML prognosis. tregs 71-76 interferon gamma Homo sapiens 33-42 35349670-12 2022 IDO1 inhibitor abrogated the effect of IFN-gamma release by AML cells on MSC-derived Treg induction. treg 85-89 interferon gamma Homo sapiens 39-48 35349670-14 2022 CONCLUSIONS: IFN-g release by AML cells induces an immune-regulatory program in MSCs and remodels BM immunological landscape toward Treg induction, contributing to an immunotolerant microenvironment. treg 132-136 interferon gamma Homo sapiens 13-18 35388305-14 2022 Conclusion: Our study suggested that APS could alleviate the symptoms of the mice infected with HSV-1, and CD8+ TRM cells in the skin lesions and the levels of IL-12 and IFN-gamma in the serum of mice with HSV-1 infection increased after the APS treatment, of which the specific underlying mechanism requires further experiments to clarify. aps 37-40 interferon gamma Homo sapiens 170-179 35371054-4 2022 Interferon (IFN)-gamma induces IDO1 expression through the Jak/STAT1 pathway and mediates Kyn production concomitantly with Trp consumption in CLL-conditioned media, while INCB018424 (ruxolitinib), a JAK1/2 inhibitor, impaired both effects. Kynurenine 90-93 interferon gamma Homo sapiens 0-22 35419291-7 2022 Interestingly, PBMCs treated with iSec presented a reduced expression of the regulators of Th1 and Th2 responses T-BET and GATA-3, as well as low expression of IFN-gamma, and co-stimulatory molecules TIM-3 and LAG-3. isec 34-38 interferon gamma Homo sapiens 160-169 35611350-6 2022 Alcohol use (positive phosphatidylethanol level) was associated with elevated IFN-gamma, tumor necrosis factor alpha (TNF-alpha), and interleukin 12p70 (IL-12p70), and smoking was associated with higher macrophage inflammatory protein 1alpha, TNF-alpha, and IL-12p70. Alcohols 0-7 interferon gamma Homo sapiens 78-87 35611350-6 2022 Alcohol use (positive phosphatidylethanol level) was associated with elevated IFN-gamma, tumor necrosis factor alpha (TNF-alpha), and interleukin 12p70 (IL-12p70), and smoking was associated with higher macrophage inflammatory protein 1alpha, TNF-alpha, and IL-12p70. phosphatidylethanol 22-41 interferon gamma Homo sapiens 78-87 35179349-8 2022 The boosted antitumor immunity was achieved mainly by the inhibition of Bruton"s tyrosine kinase activation mediated by ibrutinib, which reduced the proportion of TIBs, enhanced infiltration of CD8+ and CD4+ T cells, increased the secretion of immunogenic cytokines including IL-2 and IFN-gamma, and inhibited the proliferation of regulatory T cells and secretion of immunosuppressive cytokines including IL-10, IL-4, and TGF-beta. ibrutinib 120-129 interferon gamma Homo sapiens 285-294 35387091-4 2022 The administration of TA also inhibited (P < 0.05) the expression of intestinal pro-inflammatory cytokines including interleukin (IL)-1beta, IL-8, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) but increased (P < 0.05) jejunal IL-10 and secretory immunoglobulin A (sIgA) concentration. anethole 22-24 interferon gamma Homo sapiens 147-163 35387091-4 2022 The administration of TA also inhibited (P < 0.05) the expression of intestinal pro-inflammatory cytokines including interleukin (IL)-1beta, IL-8, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) but increased (P < 0.05) jejunal IL-10 and secretory immunoglobulin A (sIgA) concentration. anethole 22-24 interferon gamma Homo sapiens 165-174 35371054-4 2022 Interferon (IFN)-gamma induces IDO1 expression through the Jak/STAT1 pathway and mediates Kyn production concomitantly with Trp consumption in CLL-conditioned media, while INCB018424 (ruxolitinib), a JAK1/2 inhibitor, impaired both effects. Tryptophan 124-127 interferon gamma Homo sapiens 0-22 35297024-6 2022 We initiated prednisolone (PSL) 40 mg/day (0.6 mg/kg), in combination with isoniazid for a latent tuberculosis infection, because of positive results in interferon-gamma release assays. Isoniazid 75-84 interferon gamma Homo sapiens 153-169 35297024-6 2022 We initiated prednisolone (PSL) 40 mg/day (0.6 mg/kg), in combination with isoniazid for a latent tuberculosis infection, because of positive results in interferon-gamma release assays. Prednisolone 27-30 interferon gamma Homo sapiens 153-169 35217532-7 2022 Each IFN has a unique metabolic signature, with IFNG being the most associated with activation of the kynurenine pathway. Kynurenine 102-112 interferon gamma Homo sapiens 48-52 35359958-9 2022 Combining HBHA- and ESAT-6-induced IFN-gamma concentrations produced by PBMC was optimal to differentiate infected from non-infected individuals in the training cohort (100% correct classification), but 2/16 (13%) patients with aTB were misclassified in the validation cohort. HBHA 10-14 interferon gamma Homo sapiens 35-44 35287587-3 2022 We aimed to analyze the profile of Tregs and their correlation with the status of T cells activation, the expression of IL-2 and IFNgamma and the profile of HIV-1 specific antibodies response in Mozambican people living chronically with HIV-1 (PLWH-C). tregs 35-40 interferon gamma Homo sapiens 129-137 35287587-4 2022 RESULTS: In PLWH-C, the proportion of total Tregs was positively correlated with the proportion of IL-2+CD4 T cells (r = 0.647; p = 0.032) and IL-2+IFNgamma+CD8 T cells (r = 0.551; p = 0.014), while the proportions of Helios+Tregs correlated inversely with levels of IL-2+CD8 T cells (r = - 0.541; p = 0.017). tregs 44-49 interferon gamma Homo sapiens 148-156 35287715-12 2022 Also, IFNgamma gene methylation was positively associated with CO (1 week/1 mo/3 mo: Q < 0.05) and PAH456 (1 week/1 mo/3 mo: Q < 0.06). Carbon Monoxide 63-65 interferon gamma Homo sapiens 6-14 35287715-12 2022 Also, IFNgamma gene methylation was positively associated with CO (1 week/1 mo/3 mo: Q < 0.05) and PAH456 (1 week/1 mo/3 mo: Q < 0.06). pah456 99-105 interferon gamma Homo sapiens 6-14 35369435-9 2022 Interestingly, when we blunted antiviral immune responses using clodronate liposomes (which depletes antigen-presenting cells) or cyclosporin (which inhibits cytokine production that regulates T-cell proliferation), significantly lower IFN-gamma producing CD8+ T cells infiltrated into tendon tissues, resulting in reduced tendon tissues apoptosis and milder disease manifestations. Clodronic Acid 64-74 interferon gamma Homo sapiens 236-245 35359958-9 2022 Combining HBHA- and ESAT-6-induced IFN-gamma concentrations produced by PBMC was optimal to differentiate infected from non-infected individuals in the training cohort (100% correct classification), but 2/16 (13%) patients with aTB were misclassified in the validation cohort. esat-6 20-26 interferon gamma Homo sapiens 35-44 35359958-10 2022 ESAT-6-induced-IP-10 combined with HBHA-induced-IFN-gamma concentrations was selected to differentiate aTB from LTBI, and correctly classified 82%/77% of infected subjects as aTB or LTBI in the training/validation cohorts, respectively. HBHA 35-39 interferon gamma Homo sapiens 48-57 35359958-11 2022 Results obtained on WB also selected ESAT-6- and HBHA-induced IFN-gamma concentrations to provided discrimination between infected and non-infected subjects (89%/90% correct classification in the training/validation cohorts). esat-6 37-43 interferon gamma Homo sapiens 62-71 35359958-11 2022 Results obtained on WB also selected ESAT-6- and HBHA-induced IFN-gamma concentrations to provided discrimination between infected and non-infected subjects (89%/90% correct classification in the training/validation cohorts). HBHA 49-53 interferon gamma Homo sapiens 62-71 35359958-15 2022 After elimination of most non-infected subjects by combining ESAT-6 and HBHA-induced IFN-gamma, the combination of IP-10, IL-2 and GM-CSF released by either ESAT-6 or HBHA correctly identifies most patients with aTB. HBHA 72-76 interferon gamma Homo sapiens 85-94 35535108-16 2022 Conclusion: Viral eradication induced by DAAs caused a significant change in IL-10 and IFN-gamma. daas 41-45 interferon gamma Homo sapiens 87-96 35359454-5 2022 Importantly, IFNgamma-sEVs significantly improved the delivery efficiency and stability of ASO-210, the antisense oligonucleotides of miR-210 block the immune imbalance and subsequent psoriasis development. aso-210 91-98 interferon gamma Homo sapiens 13-21 35120895-0 2022 Myricetin inhibits interferon-gamma-induced PD-L1 and IDO1 expression in lung cancer cells. myricetin 0-9 interferon gamma Homo sapiens 19-35 35181476-5 2022 Immunoinformatic approaches are used to identify the potential of dvac in inducing cytotoxic T-lymphocytes, helper T-lymphocytes, Interleukin-4, Interferon-gamma and B-cell immune responses without inducing allergic responses. dvac 66-70 interferon gamma Homo sapiens 145-161 35264796-1 2022 Activated T cells secrete interferon-gamma, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme1-4. Tryptophan 73-83 interferon gamma Homo sapiens 26-42 35112740-0 2022 Time-dependent dual beneficial modulation of interferon-gamma, interleukin 5, and Treg cytokines in asthma patient peripheral blood mononuclear cells by ganoderic acid B. ganoderic acid B 153-169 interferon gamma Homo sapiens 45-61 35112740-8 2022 Following 3-day culture, GAB, but not Dex, significantly increased IL-10 and IFN-gamma levels by allergic patients" PBMCs. gab 25-28 interferon gamma Homo sapiens 77-86 35112740-12 2022 GAB simultaneously increased IL-10, IFN-gamma associated with induction of T-bet and Foxp3, while suppressing IL-5, which was associated with suppression of GATA3, demonstrating unique beneficial cytokine modulatory effect, which distinguishes from Dex"s overall suppression. gab 0-3 interferon gamma Homo sapiens 36-45 35133638-13 2022 XC8 inhibits the cough reflex and suppresses the cough potentiation by IFN-gamma. xc8 0-3 interferon gamma Homo sapiens 71-80 35226872-6 2022 In addition, mf significantly induced the frequency of interferon (IFN)-gamma+ human monocytes and at the same time induced the mRNA expression of indoleamine 2,3-dioxygenase (IDO) through an IFN-gamma-dependent mechanism; significantly enhanced tryptophan degradation (an indicator of IDO activity; P < 0.005). Tryptophan 246-256 interferon gamma Homo sapiens 192-201 35308042-9 2022 As expected, BMSCs and human umbilical cord mesenchymal stem cells (UMSCs) pretreated with CQ/TAM/IFN-gamma exerted enhanced intervention in AP and SAP mice. Tamoxifen 94-97 interferon gamma Homo sapiens 98-107 35218354-0 2022 Ruxolitinib Inhibits IFNgamma-stimulated Sjogren"s Salivary Gland MSC HLA-DR Expression and Chemokine-Dependent T-cell Migration. ruxolitinib 0-11 interferon gamma Homo sapiens 21-29 35218354-4 2022 The objective of this study was to define the immunobiology of IFNgamma-exposed SG-MSCs with and without the JAK1 & 2 inhibitor, ruxolitinib. ruxolitinib 129-140 interferon gamma Homo sapiens 63-71 35218354-8 2022 RESULTS: We found that IFNgamma promoted expression of SG-MSC immunomodulatory markers, including HLA-DR, and this expression was inhibited by ruxolitinib. ruxolitinib 143-154 interferon gamma Homo sapiens 23-31 35218354-12 2022 CONCLUSIONS: These findings establish that ruxolitinib inhibits IFNgamma-induced expression of SG-MSC immunomodulatory markers and chemokines. ruxolitinib 43-54 interferon gamma Homo sapiens 64-72 35218354-13 2022 Ruxolitinib also reverses IFNgamma-induced CD4+ T cell chemotaxis, through inhibition of CXCL9, -10, and -11. ruxolitinib 0-11 interferon gamma Homo sapiens 26-34 35197008-3 2022 METHODS: HCWs from four TB hospitals in the Northern Kyrgyz Republic were tested with the interferon-gamma release assay (IGRA) Quantiferon-TB Gold plus (QFT) for the detection of an immune response to TB as marker of TB infection. tb gold 140-147 interferon gamma Homo sapiens 90-106 35280304-6 2022 Results: Significant differences were identified in the expression levels of interferon-gamma (IFN-gamma) (P < 0.001), interleukin (IL)-6 (P = 0.008) and tumor necrosis factor-alpha (TNF-alpha) (P = 0.036) in the luminal fluid of the ES comparing between the MD and AN groups. Phenobarbital 213-220 interferon gamma Homo sapiens 77-93 35280304-6 2022 Results: Significant differences were identified in the expression levels of interferon-gamma (IFN-gamma) (P < 0.001), interleukin (IL)-6 (P = 0.008) and tumor necrosis factor-alpha (TNF-alpha) (P = 0.036) in the luminal fluid of the ES comparing between the MD and AN groups. Phenobarbital 213-220 interferon gamma Homo sapiens 95-104 35205800-10 2022 Furthermore, BP inhibited PD-L1 expression, thereby activating T-cell cytotoxicity and increasing interferon-gamma (IFN-gamma) secretion. butylidenephthalide 13-15 interferon gamma Homo sapiens 98-114 35183749-1 2022 OBJECTIVES: Interferon-gamma release assays (IGRAs), including T-SPOT.TB (TSPOT) and QuantiFERON Gold In-Tube (QFT), are important diagnostic tools for tuberculosis infection, yet little work has been done to study the performance of these tests in populations prioritized for tuberculosis testing in the United States, especially other than healthcare personnel. Terbium 70-72 interferon gamma Homo sapiens 12-28 35205800-10 2022 Furthermore, BP inhibited PD-L1 expression, thereby activating T-cell cytotoxicity and increasing interferon-gamma (IFN-gamma) secretion. butylidenephthalide 13-15 interferon gamma Homo sapiens 116-125 35251028-10 2022 In the Tregs/T effector co-culture assay, AN3025 increased T effector proliferation and enhanced interferon gamma (IFNgamma) production. an3025 42-48 interferon gamma Homo sapiens 97-113 35251028-10 2022 In the Tregs/T effector co-culture assay, AN3025 increased T effector proliferation and enhanced interferon gamma (IFNgamma) production. an3025 42-48 interferon gamma Homo sapiens 115-123 35167016-5 2022 The RNA-seq analysis revealed that the A2AR antagonist KW6002 affected the expression of the cell adhesion molecules" (CAMs) pathway and cell response to IFN-gamma in the CP. istradefylline 55-61 interferon gamma Homo sapiens 154-163 35203349-8 2022 Oral ingestion of AJ2 improved the secretion of IFN-gamma by patient derived NK cells and resulted in the better functioning of NK cells in cancer patients. 4-Methylquinolin-2-ol 18-21 interferon gamma Homo sapiens 48-57 35235887-6 2022 The molecular mechanism of piceatannol was studied in the TNFalpha/IFNgamma-induced HaCaT cell line. 3,3',4,5'-tetrahydroxystilbene 27-38 interferon gamma Homo sapiens 67-75 35235887-10 2022 Piceatannol decreased phosphorylation of JAK-STAT protein in the TNFalpha/IFNgamma-induced HaCaT cell line. 3,3',4,5'-tetrahydroxystilbene 0-11 interferon gamma Homo sapiens 74-82 35131254-1 2022 Ruxolitinib is a Janus kinase 1/2 inhibitor (JAK1/2) that blocks signal transduction of interferon-gamma, a critical cytokine involved in the pathogenesis of cutaneous lichen planus (LP). ruxolitinib 0-11 interferon gamma Homo sapiens 88-104 35144705-6 2022 In addition, moderation and mediation models examined the role of IFN-gamma for the relationship between WASO and depressed mood. waso 105-109 interferon gamma Homo sapiens 66-75 35144705-8 2022 Moreover, IFN-gamma moderated the relationship between WASO and depressed mood (p < 0.01), such that WASO was more strongly related to the depressed mood among those with higher IFN-gamma, than among those with lower IFN-gamma. waso 55-59 interferon gamma Homo sapiens 10-19 35144705-8 2022 Moreover, IFN-gamma moderated the relationship between WASO and depressed mood (p < 0.01), such that WASO was more strongly related to the depressed mood among those with higher IFN-gamma, than among those with lower IFN-gamma. waso 55-59 interferon gamma Homo sapiens 178-187 35144705-8 2022 Moreover, IFN-gamma moderated the relationship between WASO and depressed mood (p < 0.01), such that WASO was more strongly related to the depressed mood among those with higher IFN-gamma, than among those with lower IFN-gamma. waso 55-59 interferon gamma Homo sapiens 217-226 35144705-8 2022 Moreover, IFN-gamma moderated the relationship between WASO and depressed mood (p < 0.01), such that WASO was more strongly related to the depressed mood among those with higher IFN-gamma, than among those with lower IFN-gamma. waso 101-105 interferon gamma Homo sapiens 10-19 35144705-8 2022 Moreover, IFN-gamma moderated the relationship between WASO and depressed mood (p < 0.01), such that WASO was more strongly related to the depressed mood among those with higher IFN-gamma, than among those with lower IFN-gamma. waso 101-105 interferon gamma Homo sapiens 178-187 35144705-8 2022 Moreover, IFN-gamma moderated the relationship between WASO and depressed mood (p < 0.01), such that WASO was more strongly related to the depressed mood among those with higher IFN-gamma, than among those with lower IFN-gamma. waso 101-105 interferon gamma Homo sapiens 217-226 35016033-3 2022 Unexpectedly, we found that macrophage citrulline declines rapidly after interferon gamma (IFN-gamma) and/or lipopolysaccharide (LPS) stimulation, which is required for efficient proinflammatory signaling activation. Citrulline 39-49 interferon gamma Homo sapiens 73-100 35016033-4 2022 Mechanistically, IFN-gamma and/or LPS stimulation promotes signal transducers and activators of transcription 1 (STAT1)-mediated ASS1 transcription and Janus kinase2 (JAK2)-mediated phosphorylation of ASS1 at tyrosine 87, thereby leading to citrulline depletion. Tyrosine 209-217 interferon gamma Homo sapiens 17-26 35016033-4 2022 Mechanistically, IFN-gamma and/or LPS stimulation promotes signal transducers and activators of transcription 1 (STAT1)-mediated ASS1 transcription and Janus kinase2 (JAK2)-mediated phosphorylation of ASS1 at tyrosine 87, thereby leading to citrulline depletion. Citrulline 241-251 interferon gamma Homo sapiens 17-26 35204188-6 2022 Additionally, it showed potent anti-inflammatory activity by inhibiting cyclooxygenase-2 (COX-2), nitric oxide, and inducible nitric oxide synthase (iNOS) production in interferon-gamma-stimulated colon adenocarcinoma (HT-29) cells without exerting cytotoxicity. Nitric Oxide 98-110 interferon gamma Homo sapiens 169-185 35207531-0 2022 In Patients with Severe COVID-19, the Profound Decrease in the Peripheral Blood T-Cell Subsets Is Correlated with an Increase of QuantiFERON-TB Gold Plus Indeterminate Rates and Reflecting a Reduced Interferon-Gamma Production. tb gold 141-148 interferon gamma Homo sapiens 199-215 35113934-5 2022 Plasma concentrations of IFN-gamma, IP-10 and neopterin, and stimulated release of O2- from PMNs exhibited dose- and time-dependent increases after IFN-gamma administration. Neopterin 46-55 interferon gamma Homo sapiens 148-157 35113934-5 2022 Plasma concentrations of IFN-gamma, IP-10 and neopterin, and stimulated release of O2- from PMNs exhibited dose- and time-dependent increases after IFN-gamma administration. Oxygen 83-86 interferon gamma Homo sapiens 148-157 35113934-10 2022 IFN-gamma appears to increase non-oxygen dependent microbicidal functions of PMNs which could provide strategies to compensate for deficiencies, explain its clinical benefit for CGD patients and expand therapeutic applications of IFN-gamma to other disorders. Oxygen 34-40 interferon gamma Homo sapiens 0-9 35113934-10 2022 IFN-gamma appears to increase non-oxygen dependent microbicidal functions of PMNs which could provide strategies to compensate for deficiencies, explain its clinical benefit for CGD patients and expand therapeutic applications of IFN-gamma to other disorders. Oxygen 34-40 interferon gamma Homo sapiens 230-239 35057957-4 2022 In comparison with a conventional ELISA system, CAFI has a 1,000-fold higher sensitivity with the limit of detection for IFN-gamma down to 1 fg mL-1 (58.8 aM). cafi 48-52 interferon gamma Homo sapiens 121-130 35057957-6 2022 CAFI has successfully been demonstrated by detecting IFN-gamma from a diverse complex biological sample type, including human serum, whole blood, perspiration, and saliva. cafi 0-4 interferon gamma Homo sapiens 53-62 35199049-6 2022 The current literature bears strong evidence for the benefits of yoga on the levels of circulating cortisol and classical inflammatory markers, such as C-reactive protein (CRP) and cytokines such as interleukin-1 beta (IL-1beta), interleukin 6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma). Hydrocortisone 99-107 interferon gamma Homo sapiens 297-313 35199049-6 2022 The current literature bears strong evidence for the benefits of yoga on the levels of circulating cortisol and classical inflammatory markers, such as C-reactive protein (CRP) and cytokines such as interleukin-1 beta (IL-1beta), interleukin 6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma). Hydrocortisone 99-107 interferon gamma Homo sapiens 315-324 35163619-7 2022 Moreover, Cassiaside C-treated macrophages showed marked suppression of LPS/IFN-gamma-induced HIF-1alpha, pyruvate dehydrogenase kinase 1, and lactate dehydrogenase A expression, along with downregulation of the phosphoinositide 3-kinases (PI3K)/AKT/mTORC1 signaling pathway. Cassiaside C 10-22 interferon gamma Homo sapiens 76-85 35171704-10 2022 In IFN-gamma stimulated condition, pretreatment with HC-5 muM resulted in a significantly increased IL-6 and significantly decreased COX-2 expression compared to the HC untreated control group. Hydrocortisone 53-55 interferon gamma Homo sapiens 3-12 35040210-5 2022 Although the clinical manifestations and laboratory parameters improved via the nano-curcumin treatment, the mRNA expression of IFN-gamma (p = 0.006) and TNF-alpha (p = 0.04) were significantly reduced. Curcumin 85-93 interferon gamma Homo sapiens 128-137 35040210-6 2022 Besides, a considerable difference was observed between the nano-curcumin and control groups in the expression of IFN-gamma (p = 0.001), IL-1beta (p = 0.0002), and IL-6 (p = 0.008). Curcumin 65-73 interferon gamma Homo sapiens 114-123 35369634-6 2022 The expression level of miRNA-125 in serum was detected by RT-qPCR, and the levels of interleukin-2 (IL-2), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and transforming growth factor beta1 (TGF-beta1) in serum were detected. mirna-125 24-33 interferon gamma Homo sapiens 149-165 35369634-6 2022 The expression level of miRNA-125 in serum was detected by RT-qPCR, and the levels of interleukin-2 (IL-2), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and transforming growth factor beta1 (TGF-beta1) in serum were detected. mirna-125 24-33 interferon gamma Homo sapiens 167-176 35099588-5 2022 Analysis of the TASO-treated mice serum revealed elevated levels of human IFN-gamma and reduced levels of human IL-10 and TGF-beta2. taso 16-20 interferon gamma Homo sapiens 74-83 35105915-4 2022 Our study shows that IFN-gamma markedly induced the expression levels of nNOS in melanoma cells associated with increased intracellular nitric oxide (NO) levels. Nitric Oxide 136-148 interferon gamma Homo sapiens 21-30 35198736-8 2022 Results: Out of 78 participants, pro-inflammatory cytokines IFN-gamma and TNF-alpha were significantly increased in TB positive patients than TB negative patients (p < 0.05). Terbium 116-118 interferon gamma Homo sapiens 60-69 35023537-7 2022 During hemin-triggered ferroptosis, celecoxib disrupted the inflammation-related immunosuppression while roscovitine destroyed the IFN-gamma-induced up-regulation of PD-L1 via the genetic blockade effect. Roscovitine 105-116 interferon gamma Homo sapiens 131-140 35198736-9 2022 IFN-gamma value of TB positive patients (41.26 +- 41.05) was higher than TB negative (22.94 +- 44.51) patients. Terbium 19-21 interferon gamma Homo sapiens 0-9 35198736-13 2022 Conclusion: IFN-gamma and TNF-alpha were significantly higher in TB positive patients and it may act as a potential biomarker for diagnosis of genital tuberculosis. Terbium 65-67 interferon gamma Homo sapiens 12-21 35154100-0 2022 Purine-Induced IFN-gamma Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression. purine 0-6 interferon gamma Homo sapiens 15-24 35154100-0 2022 Purine-Induced IFN-gamma Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression. Uric Acid 34-43 interferon gamma Homo sapiens 15-24 35154100-8 2022 Results: Excess of purine was metabolized to UA in hepatocyte metabolism by XOR that was induced by IFN-gamma secreted in the conditioned growth medium of Jurkat cells in response to exogenous purine, but it did not directly induce XOR expression. purine 19-25 interferon gamma Homo sapiens 100-109 35154100-8 2022 Results: Excess of purine was metabolized to UA in hepatocyte metabolism by XOR that was induced by IFN-gamma secreted in the conditioned growth medium of Jurkat cells in response to exogenous purine, but it did not directly induce XOR expression. Uric Acid 45-47 interferon gamma Homo sapiens 100-109 35154100-8 2022 Results: Excess of purine was metabolized to UA in hepatocyte metabolism by XOR that was induced by IFN-gamma secreted in the conditioned growth medium of Jurkat cells in response to exogenous purine, but it did not directly induce XOR expression. purine 193-199 interferon gamma Homo sapiens 100-109 35154100-10 2022 Clinical data showed positive correlation of serum IFN-gamma with both purine and UA, and associated risk of hyperuricemia. purine 71-77 interferon gamma Homo sapiens 51-60 35154100-11 2022 Conclusion: Purine not only acts as a metabolic substrate of XOR for UA production, but it induces inflammation through IFN-gamma secretion that stimulates UA production through elevation of XOR expression. purine 12-18 interferon gamma Homo sapiens 120-129 35140700-11 2021 Specifically, the results of lectin microarray showed the galactose level of IgG was increased by IFN-gamma stimulation (p<0.05), and the sialylation of IgG was increased by IL-21 and IL-17A (p<0.05). Galactose 58-67 interferon gamma Homo sapiens 98-107 35059859-10 2022 Both treatments predicted activation of IFNgamma, IL1beta, TNF as upstream regulators, specially this effect was higher in dasatinib. Dasatinib 123-132 interferon gamma Homo sapiens 40-48 35064144-10 2022 Then, in vitro experiments showed that quercetin interfered with Th1/Th2 balance by acting on IL-6 and IFN-gamma to modulate the immune system in treating OLP. Quercetin 39-48 interferon gamma Homo sapiens 103-112 35096641-4 2021 IFN-gamma stimulation promoted intracellular glutamine degradation in human neuronal cells. Glutamine 45-54 interferon gamma Homo sapiens 0-9 35126303-7 2021 The proportion of CD19+BAFFR+, CD19+IFN-gamma+, and CD19+IL-10+ subsets decreased significantly after TAC therapy (p = 0.015, 0.018, and 0.042, respectively). Tacrolimus 102-105 interferon gamma Homo sapiens 36-45 35126303-9 2021 Conclusion: Possibly through increasing regulatory B and suppressing BAFFR+ B and interferon (IFN)-gamma+ B subsets, TAC could decrease relapse. Tacrolimus 117-120 interferon gamma Homo sapiens 82-104 35126344-10 2021 However, preventing prostaglandin E2 (PGE2) synthesis or blocking PGE2 binding to the cognate EP2/EP4 receptors, restored IFNgamma and TNFalpha production in OEC-conditioned T cells. Dinoprostone 20-36 interferon gamma Homo sapiens 122-130 35126344-10 2021 However, preventing prostaglandin E2 (PGE2) synthesis or blocking PGE2 binding to the cognate EP2/EP4 receptors, restored IFNgamma and TNFalpha production in OEC-conditioned T cells. Dinoprostone 38-42 interferon gamma Homo sapiens 122-130 35126344-10 2021 However, preventing prostaglandin E2 (PGE2) synthesis or blocking PGE2 binding to the cognate EP2/EP4 receptors, restored IFNgamma and TNFalpha production in OEC-conditioned T cells. Dinoprostone 66-70 interferon gamma Homo sapiens 122-130 35096641-3 2021 Here, we show that abnormal glutamine metabolism caused by both interferon-gamma (IFN-gamma) stimulation and T. gondii infection induce cyst formation in human neuroblastoma cells regardless of the anti-T. gondii host factor nitric oxide (NO) level or Indoleamine 2,3-dioxygenase-1 (IDO1) expression. Glutamine 28-37 interferon gamma Homo sapiens 82-91 35023427-0 2022 Adenosine receptor A2a blockade by caffeine increases IFN-gamma production in Th1 cells from patients with rheumatoid arthritis. Caffeine 35-43 interferon gamma Homo sapiens 54-63 35023427-8 2022 RESULTS: Caffeine promoted IFN-gamma production in Th1 cells in vitro. Caffeine 9-17 interferon gamma Homo sapiens 27-36 35023427-9 2022 Significantly higher concentrations of caffeine were required to increase IFN-gamma levels in Th1 cells from healthy individuals compared to Th1 cells from patients with RA. Caffeine 39-47 interferon gamma Homo sapiens 74-83 35011106-8 2022 Curcumin significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-gamma, and IL-4) and lipid peroxidation. Curcumin 0-8 interferon gamma Homo sapiens 73-82 35023427-11 2022 Caffeine-driven IFN-gamma production was completely reversed by adenosine, a competitive agonist of adenosine receptor A2a. Caffeine 0-8 interferon gamma Homo sapiens 16-25 35023427-11 2022 Caffeine-driven IFN-gamma production was completely reversed by adenosine, a competitive agonist of adenosine receptor A2a. Adenosine 64-73 interferon gamma Homo sapiens 16-25 35023427-13 2022 CONCLUSION: Caffeine promotes IFN-gamma production in Th1 cells from RA patients in vitro by competitive inhibition of adenosine receptor A2a. Caffeine 12-20 interferon gamma Homo sapiens 30-39 35054851-2 2022 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine 72-86 interferon gamma Homo sapiens 137-153 35054851-2 2022 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine 72-86 interferon gamma Homo sapiens 155-164 35054851-2 2022 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine 352-366 interferon gamma Homo sapiens 137-153 35054851-2 2022 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine 352-366 interferon gamma Homo sapiens 155-164 35054851-3 2022 Norepinephrine suppressed IL-17 and IFN-gamma production by the anti-CD3/anti-CD28-microbead-stimulated CD4+ T cells in both groups. Norepinephrine 0-14 interferon gamma Homo sapiens 36-45 35054851-7 2022 Conversely, beta2-adrenoreceptor activation by formoterol decreased IFN-gamma production and did not affect IL-17 production in both groups. Formoterol Fumarate 47-57 interferon gamma Homo sapiens 68-77 35054851-8 2022 These data illustrate the inhibitory effect of norepinephrine on IL-17 and IFN-gamma production by CD4+ T cells in MS. Norepinephrine 47-61 interferon gamma Homo sapiens 75-84 35054851-9 2022 The inhibitory effect of norepinephrine on IFN-gamma production by CD4+ T cells in MS could be mediated via beta2-adrenoreceptor activation. Norepinephrine 25-39 interferon gamma Homo sapiens 43-52 34984539-10 2022 The activity of NK cells and interferon-gamma levels were increased in the circulation, indicating augmentation of antitumor immunity by GEN0101. gen0101 137-144 interferon gamma Homo sapiens 29-45 34269660-7 2022 IFN-gamma upregulates the enzyme indoleamine 2,3-dioxygenase (IDO), decreasing serum levels of the Trp and increasing metabolite levels of kynurenine. Tryptophan 99-102 interferon gamma Homo sapiens 0-9 34983619-5 2022 RESULTS: After 12 weeks of lenabasum treatment, IHC staining showed that CD4+ T cells, CB2R, IL-31, IFN-gamma, and IFN-beta cytokines were downregulated. lenabasum 27-36 interferon gamma Homo sapiens 100-109 34983619-9 2022 These CB2R+ cells in the skin produce IL-31, IL-4, IFN-gamma, and IFN-beta. cb2r 6-10 interferon gamma Homo sapiens 51-60 35043219-5 2022 Importantly, the levels of salivary IL-6, IL-10, IFN-gamma, and TNF-alpha in RAS patients were significantly decreased following prednisone treatment (all P < 0.001). Prednisone 129-139 interferon gamma Homo sapiens 49-58 34269660-7 2022 IFN-gamma upregulates the enzyme indoleamine 2,3-dioxygenase (IDO), decreasing serum levels of the Trp and increasing metabolite levels of kynurenine. Kynurenine 139-149 interferon gamma Homo sapiens 0-9 34843183-0 2022 The mineralocorticoid receptor blocker spironolactone lowers plasma interferon-gamma and interleukin-6 in patients with type 2 diabetes and treatment-resistant hypertension. Spironolactone 39-53 interferon gamma Homo sapiens 68-84 34969431-0 2022 VIDAS TB-IGRA reagents induce a CD4+ and CD8+ T-cell IFN-gamma response for both TB infection and active TB. vidas tb- 0-10 interferon gamma Homo sapiens 54-63 34969431-0 2022 VIDAS TB-IGRA reagents induce a CD4+ and CD8+ T-cell IFN-gamma response for both TB infection and active TB. Terbium 82-84 interferon gamma Homo sapiens 54-63 34843183-6 2022 RESULTS: Spironolactone significantly reduced plasma IFN-gamma and IL-6 while IL-17A, TNF-alpha, IL-1beta and IL-10 were unchanged. Spironolactone 9-23 interferon gamma Homo sapiens 53-62 34843183-13 2022 CONCLUSION: The antihypertensive action of spironolactone in resistant hypertensive patients is associated with suppressed IFN-gamma and IL-6 and not IL-17A. Spironolactone 43-57 interferon gamma Homo sapiens 123-132 35090381-8 2022 Moreover, MG1131 increased NK cell-mediated tumor killing activities, inhibited immunosuppressive activity of regulatory T (Treg) cells from healthy donors, and restored interferon-gamma secretion from peripheral blood mononuclear cells derived from multiple myeloma patients. mg1131 10-16 interferon gamma Homo sapiens 170-186 35307679-14 2022 CONCLUSION: Conclusions: The obtained findings indicate the effect of tiotropium bromide on the reduction of interferon-gamma and reduce of collagen-IV levels, which depend on the duration of its use. Tiotropium Bromide 70-88 interferon gamma Homo sapiens 109-125 35221867-12 2022 Remarkably, the anti-leukaemic cytotoxicity positively correlated with the IFNy secretion in TCD3+, TCD4+, TCD8+, and NKCD56+ cells. tcd3+ 93-98 interferon gamma Homo sapiens 75-79 35221867-12 2022 Remarkably, the anti-leukaemic cytotoxicity positively correlated with the IFNy secretion in TCD3+, TCD4+, TCD8+, and NKCD56+ cells. tcd4+ 100-105 interferon gamma Homo sapiens 75-79 35221867-14 2022 The CSA in this regard proved to be a convenient and reproducible technique to detect and phenotypically characterise IFNy-secreting cells. Cyclosporine 4-7 interferon gamma Homo sapiens 118-122 2479429-8 1989 We conclude that overproduction of IFN-gamma and TNF-alpha by lectin-stimulated PBMNCs is an intrinsic abnormality of SAA unrelated to blood transfusions. saa 118-121 interferon gamma Homo sapiens 35-44 2512344-6 1989 Induction of Leu 13 Ag expression by IFN-gamma was suppressed by cycloheximide. Cycloheximide 65-78 interferon gamma Homo sapiens 37-46 2512345-11 1989 Hemin and Sn-protoporphyrin stimulate TNF-alpha and IFN-gamma production by PBMC. tin protoporphyrin IX 10-27 interferon gamma Homo sapiens 52-61 2531041-6 1989 Treatment of U937 cells with dexamethasone did not significantly change the level of Fc gamma RII transcripts, but was able to inhibit by up to 50% the increase seen following interferon-gamma treatment. Dexamethasone 29-42 interferon gamma Homo sapiens 176-192 2531041-8 1989 Treatment with dexamethasone caused a small, but significant, decrease in Fc gamma RII protein, and inhibited by 20-60% the induction of Fc gamma RII by interferon-gamma. Dexamethasone 15-28 interferon gamma Homo sapiens 153-169 2531041-11 1989 Treatment with dexamethasone decreased Fc gamma RI expression by 39%, and also inhibited by 40% the increase induced by interferon-gamma. Dexamethasone 15-28 interferon gamma Homo sapiens 120-136 2531041-13 1989 However, interferon-gamma treatment increased Fc gamma RI expression on monocytes, and this increase was further augmented by treatment with dexamethasone. Dexamethasone 141-154 interferon gamma Homo sapiens 9-25 9271410-10 1997 Moreover, both EGF-induced apoptosis and IFN-gamma-induced apoptosis were effectively blocked by Z-Val-Ala-Asp-fluoromethylketone (ZVAD) in all the cells tested, and studies from ICE-deficient cells indicated that ICE gene expression was necessary for IFN-gamma-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 97-129 interferon gamma Homo sapiens 41-50 9271410-10 1997 Moreover, both EGF-induced apoptosis and IFN-gamma-induced apoptosis were effectively blocked by Z-Val-Ala-Asp-fluoromethylketone (ZVAD) in all the cells tested, and studies from ICE-deficient cells indicated that ICE gene expression was necessary for IFN-gamma-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 97-129 interferon gamma Homo sapiens 252-261 9271410-10 1997 Moreover, both EGF-induced apoptosis and IFN-gamma-induced apoptosis were effectively blocked by Z-Val-Ala-Asp-fluoromethylketone (ZVAD) in all the cells tested, and studies from ICE-deficient cells indicated that ICE gene expression was necessary for IFN-gamma-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 131-135 interferon gamma Homo sapiens 41-50 9271410-10 1997 Moreover, both EGF-induced apoptosis and IFN-gamma-induced apoptosis were effectively blocked by Z-Val-Ala-Asp-fluoromethylketone (ZVAD) in all the cells tested, and studies from ICE-deficient cells indicated that ICE gene expression was necessary for IFN-gamma-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 131-135 interferon gamma Homo sapiens 252-261 2556475-6 1989 Production of superoxide anion by IFN-gamma treated U-937 cells was stimulated by My 43 but not by other IgM mAb recognizing myeloid cells. Superoxides 14-30 interferon gamma Homo sapiens 34-43 2556478-7 1989 Dexamethasone also inhibited both basal and IFN-gamma-augmented Fc gamma RI expression and PMA-augmented Fc gamma RII expression and phagocytosis, but did not affect IFN-gamma-augmented phagocytosis of Eo"-IgG. Dexamethasone 0-13 interferon gamma Homo sapiens 44-53 2479429-9 1989 Normalization of production of IFN-gamma and TNF-alpha accompanying a clinical response to cyclosporin-A may cautiously be taken as further evidence suggesting a pathogenetic role of cytokine overproduction in SAA. Cyclosporine 91-104 interferon gamma Homo sapiens 31-40 2479429-9 1989 Normalization of production of IFN-gamma and TNF-alpha accompanying a clinical response to cyclosporin-A may cautiously be taken as further evidence suggesting a pathogenetic role of cytokine overproduction in SAA. saa 210-213 interferon gamma Homo sapiens 31-40 2555698-4 1989 Activation by IFN-gamma was slower, sustained, and delayed by cycloheximide. Cycloheximide 62-75 interferon gamma Homo sapiens 14-23 2576655-5 1989 The other line (TFATx), established from a co-culture between the autologous PBL, lethally irradiated TFTx and the autologous melanoma cells TF-M, is IL-2-dependent for growth, secretes IFN gamma and TNF alpha and beta. tfatx 16-21 interferon gamma Homo sapiens 186-195 2481708-3 1989 Both interferons reduced the growth rate of the cells: incorporation of radiolabelled thymidine was reduced by 15-45% in the presence of IFN-alpha and by 20-53% with IFN-gamma. Thymidine 86-95 interferon gamma Homo sapiens 166-175 2511277-4 1989 Results indicated that 100 micrograms IFN-gamma applied once weekly was biologically active with induction of serum beta 2-microglobulin and neopterin. Neopterin 141-150 interferon gamma Homo sapiens 38-47 12412754-2 1989 Colchicine inhibits interferon-gamma induced expression of HLA-DR on gut epithelial cell line. Colchicine 0-10 interferon gamma Homo sapiens 20-36 2507204-0 1989 Interleukin 2, interleukin 2 receptor, and interferon-gamma synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans. Tetradecanoylphorbol Acetate 93-118 interferon gamma Homo sapiens 43-59 2507204-0 1989 Interleukin 2, interleukin 2 receptor, and interferon-gamma synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans. Calcium 123-130 interferon gamma Homo sapiens 43-59 2507204-0 1989 Interleukin 2, interleukin 2 receptor, and interferon-gamma synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans. Calcimycin 141-147 interferon gamma Homo sapiens 43-59 12412754-3 1989 The effects of colchicine and vinblastine on interferon-gamma (IFN-gamma) induced expression of HLA-DR antigens on the HT-29 colonic carcinoma cell line was investigated in vitro. Colchicine 15-25 interferon gamma Homo sapiens 45-72 12412754-3 1989 The effects of colchicine and vinblastine on interferon-gamma (IFN-gamma) induced expression of HLA-DR antigens on the HT-29 colonic carcinoma cell line was investigated in vitro. Vinblastine 30-41 interferon gamma Homo sapiens 45-72 2511058-4 1989 Interferon-gamma treatment activated locally the macrophages and induced a rise in neopterin urine, serum, and ascites levels. Neopterin 83-92 interferon gamma Homo sapiens 0-16 2511225-3 1989 The present report concerns the effect of recombinant interferon-gamma (rIFN-gamma) on luminol-dependent chemiluminescence, macrophage migration and myelin phagocytosis in organ cultures. Luminol 87-94 interferon gamma Homo sapiens 54-70 2509363-4 1989 Tryptophan degradation was enhanced in the TNF-treated cells and was much further increased when the cells were treated with both TNF and IFN-gamma at concentrations at which IFN-gamma by itself had very little effect. Tryptophan 0-10 interferon gamma Homo sapiens 138-147 2509363-4 1989 Tryptophan degradation was enhanced in the TNF-treated cells and was much further increased when the cells were treated with both TNF and IFN-gamma at concentrations at which IFN-gamma by itself had very little effect. Tryptophan 0-10 interferon gamma Homo sapiens 175-184 2509562-1 1989 The effect of IL-4 on the IFN-gamma-induced state of activation of cultured human monocytes was investigated with regard to their ability to produce hydrogen peroxide and their antileishmanial capacity towards the intracellular parasite Leishmania donovani. Hydrogen Peroxide 149-166 interferon gamma Homo sapiens 26-35 2509562-2 1989 IL-4 was found to inhibit the IFN-gamma-dependent hydrogen peroxide production of monocytes. Hydrogen Peroxide 50-67 interferon gamma Homo sapiens 30-39 2509562-3 1989 Treatment of monocytes with IFN-gamma (200 to 600 U/ml) for 48 h increased the hydrogen peroxide production fourfold above background. Hydrogen Peroxide 79-96 interferon gamma Homo sapiens 28-37 2572558-2 1989 The in vitro addition of recombinant gamma interferon (IFN-gamma) to cultures of peripheral blood lymphocytes obtained from patients with AIDS resulted in an augmented proliferative response [( 3H]thymidine uptake) to phytohemagglutinin (PHA) and an enrichment in CD4+ and CD8+ T lymphocytes. Tritium 194-196 interferon gamma Homo sapiens 37-64 2572558-2 1989 The in vitro addition of recombinant gamma interferon (IFN-gamma) to cultures of peripheral blood lymphocytes obtained from patients with AIDS resulted in an augmented proliferative response [( 3H]thymidine uptake) to phytohemagglutinin (PHA) and an enrichment in CD4+ and CD8+ T lymphocytes. Thymidine 197-206 interferon gamma Homo sapiens 37-64 2513475-6 1989 A recessive mutant, selected in 6-thioguanine plus IFN, was completely resistant to IFN-alpha but responded normally to IFN-gamma and, unexpectedly, partially to IFN-beta. Thioguanine 32-45 interferon gamma Homo sapiens 120-129 2478362-5 1989 Since a single cis-acting element can confer inducibility both to interferons, and to virus and double-stranded RNA, we tested the effect of 2-aminopurine on gene activation by interferon-alpha and interferon-gamma. 2-Aminopurine 141-154 interferon gamma Homo sapiens 198-214 2790198-11 1989 Acivicin potentiated the differentiating effects of interferon-gamma, tumor necrosis factor, dihydroxyvitamin D3, dimethylsulfoxide, and retinoic acid. acivicin 0-8 interferon gamma Homo sapiens 52-68 2476360-5 1989 Pretreatment of animals with rat interferon gamma significantly reduced theophylline clearance in the intact rat but neither human interferon alpha A nor human interferon gamma altered theophylline elimination in vivo. Theophylline 72-84 interferon gamma Homo sapiens 33-49 2476360-8 1989 Rat interferon gamma (but not human interferon alpha A) decreased levels of total hepatic microsomal P450 and reduced androstenedione 16 beta-hydroxylation. Androstenedione 118-133 interferon gamma Homo sapiens 4-20 2511088-5 1989 Stimulation of macrophages isolated from normal colon with interferon-gamma produced only a small increase in the proportion of cells showing release of oxygen radicals. Reactive Oxygen Species 153-168 interferon gamma Homo sapiens 59-75 2561625-5 1989 The treatment of the nonadherent cells with 0.1-1000 U/ml of Interferon (IFN-gamma) for 24 hours resulted in a dose dependent increase in superoxide generation. Superoxides 138-148 interferon gamma Homo sapiens 73-82 2516865-3 1989 Using a combined treatment with cycloheximide and actinomycin D we observed that in HeLa cells IFN-alpha did not need ongoing protein synthesis to induce the enzyme, whereas the addition of cycloheximide prevented the induction by IFN-gamma. Cycloheximide 32-45 interferon gamma Homo sapiens 231-240 2516865-3 1989 Using a combined treatment with cycloheximide and actinomycin D we observed that in HeLa cells IFN-alpha did not need ongoing protein synthesis to induce the enzyme, whereas the addition of cycloheximide prevented the induction by IFN-gamma. Dactinomycin 50-63 interferon gamma Homo sapiens 231-240 2516865-3 1989 Using a combined treatment with cycloheximide and actinomycin D we observed that in HeLa cells IFN-alpha did not need ongoing protein synthesis to induce the enzyme, whereas the addition of cycloheximide prevented the induction by IFN-gamma. Cycloheximide 190-203 interferon gamma Homo sapiens 231-240 2561625-6 1989 After 72 hours of incubation with IFN-gamma (1000 U/ml) the amount of superoxide generated by the nonadherent cells was elevated to 20.5 +/- 1.4 nmoles/10(6) cells/15 min, similar to that of the adherent cells (24.5 +/- 1.2 nmoles/10(6) cells/15 min untreated adherent monocytes). Superoxides 70-80 interferon gamma Homo sapiens 34-43 2561625-7 1989 The generation of superoxide in the IFN-gamma treated nonadherent monocytes stimulated by E. coli 0-128 was significantly reduced by addition of mannose. Superoxides 18-28 interferon gamma Homo sapiens 36-45 2476404-1 1989 Effect of human interferon beta (IFN beta) or interferon gamma (IFN gamma) on cellular uptake of adriamycin (ADM) was measured in 3 in vitro-cultured human tumor cell lines. Doxorubicin 97-107 interferon gamma Homo sapiens 46-62 2561625-7 1989 The generation of superoxide in the IFN-gamma treated nonadherent monocytes stimulated by E. coli 0-128 was significantly reduced by addition of mannose. Mannose 145-152 interferon gamma Homo sapiens 36-45 2560916-6 1989 Treatment of the spleen cell donors with rabbit anti-asialo GM1 (AAGM1) abolished early production of IFN gamma in virus-infected female spleen cell cultures and reduced the early IL-2 production by infected male and female cells. G(M1) Ganglioside 60-63 interferon gamma Homo sapiens 102-111 2557054-3 1989 This observation may be pertinent to the recurrence of some of the opportunistic infections associated with AIDS but more importantly, if reflecting a general defect in leukotriene production, it may provide further understanding of the mechanism which leads to reduced natural killer-cell activity, interleukin-2 and interferon-gamma production in AIDS. Leukotrienes 169-180 interferon gamma Homo sapiens 318-334 2506279-6 1989 1(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, a protein kinase inhibitor, inhibited the formation of macrophage-derived giant cells when added before phorbol ester and IFN-gamma. 1(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride 0-60 interferon gamma Homo sapiens 184-193 2507660-10 1989 Furthermore, if cycloheximide was added 24 h after IFN-gamma, it actually caused a superinduction of HLA-B transcripts. Cycloheximide 16-29 interferon gamma Homo sapiens 51-60 2510291-7 1989 After anti-schistosomal therapy with praziquantel, mitogen-induced IL-2 and IFN-gamma activities became normal within 3 months in intestinal schistosomiasis, and within 6 months in the hepatosplenic patient group. Praziquantel 37-49 interferon gamma Homo sapiens 76-85 2554490-3 1989 Pretreatment of T84 cell layers with IFN-gamma for 24 h (but not for 3 h) markedly decreased the Cl- secretory response to vaso-active intestinal polypeptide (VIP) and to cholera toxin and carbachol without appreciably affecting the overall morphology, electrical resistance, or cyclic AMP response of the T84 cell monolayer. Carbachol 189-198 interferon gamma Homo sapiens 37-46 2554490-3 1989 Pretreatment of T84 cell layers with IFN-gamma for 24 h (but not for 3 h) markedly decreased the Cl- secretory response to vaso-active intestinal polypeptide (VIP) and to cholera toxin and carbachol without appreciably affecting the overall morphology, electrical resistance, or cyclic AMP response of the T84 cell monolayer. Cyclic AMP 279-289 interferon gamma Homo sapiens 37-46 2511835-0 1989 Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma. sapropterin 22-41 interferon gamma Homo sapiens 129-145 2511835-1 1989 In all of eight tested human cells and cell lines with inducible indoleamine 2,3-dioxygenase (EC 1.13.11.17) tetrahydrobiopterin biosynthesis was activated by interferon-gamma. sapropterin 109-128 interferon gamma Homo sapiens 159-175 2476404-1 1989 Effect of human interferon beta (IFN beta) or interferon gamma (IFN gamma) on cellular uptake of adriamycin (ADM) was measured in 3 in vitro-cultured human tumor cell lines. Doxorubicin 97-107 interferon gamma Homo sapiens 64-73 2476404-1 1989 Effect of human interferon beta (IFN beta) or interferon gamma (IFN gamma) on cellular uptake of adriamycin (ADM) was measured in 3 in vitro-cultured human tumor cell lines. Doxorubicin 109-112 interferon gamma Homo sapiens 64-73 2477252-5 1989 IFN-gamma re-induced ICAM-1 on the CTEC, and the ability of CTEC to bind to thymocytes was also increased by IFN-gamma treatment. ctec 60-64 interferon gamma Homo sapiens 109-118 2814975-4 1989 Recently it has been shown that the immuno-modulating compound interferon-gamma can stimulate oxygen metabolism in the phagocytes of these patients. Oxygen 94-100 interferon gamma Homo sapiens 63-79 2768247-3 1989 Treatment with IFN-gamma resulted in a slight decrease in the expression of [35S]chondroitin sulfate proteoglycan (CSPG) in both monocytes and MDM, whereas LPS treatment increased the [35S]CSPG expression 1.8 and 2.2 times, respectively. Sulfur-35 77-80 interferon gamma Homo sapiens 15-24 2768247-3 1989 Treatment with IFN-gamma resulted in a slight decrease in the expression of [35S]chondroitin sulfate proteoglycan (CSPG) in both monocytes and MDM, whereas LPS treatment increased the [35S]CSPG expression 1.8 and 2.2 times, respectively. Sulfur-35 185-188 interferon gamma Homo sapiens 15-24 2477252-5 1989 IFN-gamma re-induced ICAM-1 on the CTEC, and the ability of CTEC to bind to thymocytes was also increased by IFN-gamma treatment. ctec 35-39 interferon gamma Homo sapiens 0-9 2477252-5 1989 IFN-gamma re-induced ICAM-1 on the CTEC, and the ability of CTEC to bind to thymocytes was also increased by IFN-gamma treatment. ctec 60-64 interferon gamma Homo sapiens 0-9 2503544-0 1989 Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide. Oxygen 106-112 interferon gamma Homo sapiens 35-51 2807873-5 1989 All peritoneal macrophages obtained from DMN-exposed animals demonstrated enhanced production of PGE2 following stimulation with either endotoxin or IFN-gamma as compared to macrophages obtained from vehicle-exposed macrophages. Dimethylnitrosamine 41-44 interferon gamma Homo sapiens 149-158 2807873-5 1989 All peritoneal macrophages obtained from DMN-exposed animals demonstrated enhanced production of PGE2 following stimulation with either endotoxin or IFN-gamma as compared to macrophages obtained from vehicle-exposed macrophages. Dinoprostone 97-101 interferon gamma Homo sapiens 149-158 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Kynurenine 145-155 interferon gamma Homo sapiens 64-73 2503544-0 1989 Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide. Tryptophan 135-145 interferon gamma Homo sapiens 35-51 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Kynurenine 145-155 interferon gamma Homo sapiens 64-73 2503544-0 1989 Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide. NAD 189-222 interferon gamma Homo sapiens 35-51 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Tryptophan 182-192 interferon gamma Homo sapiens 29-38 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Tryptophan 182-192 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Tryptophan 122-132 interferon gamma Homo sapiens 29-38 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Tryptophan 182-192 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Tryptophan 182-192 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Tryptophan 122-132 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Tryptophan 243-255 interferon gamma Homo sapiens 29-38 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Tryptophan 243-255 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Tryptophan 122-132 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Tryptophan 243-255 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Tryptophan 243-255 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Tryptophan 122-132 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Amino Acids, Aromatic 271-291 interferon gamma Homo sapiens 29-38 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Amino Acids, Aromatic 271-291 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Amino Acids, Aromatic 271-291 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Amino Acids, Aromatic 271-291 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Amino Acids, Essential 299-320 interferon gamma Homo sapiens 29-38 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Amino Acids, Essential 299-320 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Amino Acids, Essential 299-320 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Amino Acids, Essential 299-320 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. D-Tryptophan 325-337 interferon gamma Homo sapiens 29-38 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Kynurenine 145-155 interferon gamma Homo sapiens 29-38 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. D-Tryptophan 325-337 interferon gamma Homo sapiens 64-73 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. D-Tryptophan 325-337 interferon gamma Homo sapiens 64-73 2769391-8 1989 Interferon-gamma treatment in vitro increased the percentage of CG 12-positive cells by 12% and the amount of cell-surface CG 12 antigens by 38% as compared to untreated cells. cysteinylglycine 64-66 interferon gamma Homo sapiens 0-16 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. D-Tryptophan 325-337 interferon gamma Homo sapiens 64-73 2769391-8 1989 Interferon-gamma treatment in vitro increased the percentage of CG 12-positive cells by 12% and the amount of cell-surface CG 12 antigens by 38% as compared to untreated cells. cysteinylglycine 123-125 interferon gamma Homo sapiens 0-16 2503544-4 1989 Cell lines most sensitive to IFN-gamma (inhibited by 10-30 U/ml IFN-gamma in 3 d) were stimulated by IFN-gamma to oxidize tryptophan in media to kynurenine and completely eliminated tryptophan from the culture media after 48-72 h. Addition of L-tryptophan, but not other aromatic amino acids, other essential amino acids, or D-tryptophan, prevented inhibition of cell growth by IFN-gamma. Kynurenine 145-155 interferon gamma Homo sapiens 64-73 2503544-5 1989 The amount of IFN-gamma required to yield 50% inhibition of cell growth was directly related to the concentration of L-tryptophan in culture media and increased from approximately 3 to 600 U/ml as the concentration of tryptophan in the media was increased from 25 to 1,000 microM. Tryptophan 117-129 interferon gamma Homo sapiens 14-23 2503544-5 1989 The amount of IFN-gamma required to yield 50% inhibition of cell growth was directly related to the concentration of L-tryptophan in culture media and increased from approximately 3 to 600 U/ml as the concentration of tryptophan in the media was increased from 25 to 1,000 microM. Tryptophan 119-129 interferon gamma Homo sapiens 14-23 2501389-10 1989 Cyclosporin A, which does not prevent PKC-induced CD69 expression, completely suppressed CD69-induced IL-2 and IFN-gamma gene expression. Cyclosporine 0-13 interferon gamma Homo sapiens 111-120 2503544-7 1989 Inhibition by IFN-gamma (100-300 U/ml after 5-6 d) was, however, completely prevented by addition of two inhibitors of adenosine diphosphate-ribosyl transferase (ADP-RT), 3-aminobenzamide or nicotinamide. 3-aminobenzamide 171-187 interferon gamma Homo sapiens 14-23 2503544-7 1989 Inhibition by IFN-gamma (100-300 U/ml after 5-6 d) was, however, completely prevented by addition of two inhibitors of adenosine diphosphate-ribosyl transferase (ADP-RT), 3-aminobenzamide or nicotinamide. Niacinamide 191-203 interferon gamma Homo sapiens 14-23 2503544-10 1989 All tumor cell lines tested had reduced levels of intracellular NAD after treatment with IFN-gamma and loss of NAD preceded inhibition of cell growth by 12-24 h. Inhibitors of IFN-gamma-mediated inhibition of cell growth prevented loss of levels of intracellular NAD. NAD 64-67 interferon gamma Homo sapiens 89-98 2503544-10 1989 All tumor cell lines tested had reduced levels of intracellular NAD after treatment with IFN-gamma and loss of NAD preceded inhibition of cell growth by 12-24 h. Inhibitors of IFN-gamma-mediated inhibition of cell growth prevented loss of levels of intracellular NAD. NAD 64-67 interferon gamma Homo sapiens 176-185 2503544-10 1989 All tumor cell lines tested had reduced levels of intracellular NAD after treatment with IFN-gamma and loss of NAD preceded inhibition of cell growth by 12-24 h. Inhibitors of IFN-gamma-mediated inhibition of cell growth prevented loss of levels of intracellular NAD. NAD 111-114 interferon gamma Homo sapiens 176-185 2503544-10 1989 All tumor cell lines tested had reduced levels of intracellular NAD after treatment with IFN-gamma and loss of NAD preceded inhibition of cell growth by 12-24 h. Inhibitors of IFN-gamma-mediated inhibition of cell growth prevented loss of levels of intracellular NAD. NAD 111-114 interferon gamma Homo sapiens 176-185 2503544-14 1989 Increased amounts of superoxide anion were released from ME180 and A549 cells after culture with IFN-gamma. Superoxides 21-37 interferon gamma Homo sapiens 97-106 2503544-15 1989 Reduced oxygen concentration decreased the ability of IFN-gamma to inhibit tumor cell growth in vitro. Oxygen 8-14 interferon gamma Homo sapiens 54-63 2503544-17 1989 Elevation or reduction of intracellular glutathione concentrations lowered or raised sensitivity of cell lines to IFN-gamma, respectively. Glutathione 40-51 interferon gamma Homo sapiens 114-123 2506547-6 1989 This genetic evidence indicates that the major pathway of IFN-gamma cytotoxicity in this cell line is mediated primarily by induction of indoleamine 2,3-dioxygenase and deprivation of L-Trp. Tryptophan 184-189 interferon gamma Homo sapiens 58-67 2782974-2 1989 Interferon gamma, derived from antigen activated T lymphocytes, stimulates macrophages to synthesise and release neopterin into the culture supernatant in vitro. Neopterin 113-122 interferon gamma Homo sapiens 0-16 2546966-1 1989 We have previously demonstrated that interferon-gamma (IFN-gamma) induced HLA-DR antigen and also inhibited thyrotropin (TSH)-induced triiodothyronine (T3) and thyroglobulin (Tg) secretion from cultured human thyrocytes. Thyrotropin 121-124 interferon gamma Homo sapiens 55-64 2546966-1 1989 We have previously demonstrated that interferon-gamma (IFN-gamma) induced HLA-DR antigen and also inhibited thyrotropin (TSH)-induced triiodothyronine (T3) and thyroglobulin (Tg) secretion from cultured human thyrocytes. Triiodothyronine 134-150 interferon gamma Homo sapiens 55-64 2546966-1 1989 We have previously demonstrated that interferon-gamma (IFN-gamma) induced HLA-DR antigen and also inhibited thyrotropin (TSH)-induced triiodothyronine (T3) and thyroglobulin (Tg) secretion from cultured human thyrocytes. Triiodothyronine 152-154 interferon gamma Homo sapiens 55-64 2546966-2 1989 In order to further clarify the inhibitory effect of IFN-gamma on TSH-stimulated thyroid hormone secretion, we have examined human thyroid peroxidase (TPO) gene expression. Thyrotropin 66-69 interferon gamma Homo sapiens 53-62 2546966-8 1989 IFN-gamma also inhibited 8-bromo-cyclic AMP-stimulated TPO mRNA levels. 8-Bromo Cyclic Adenosine Monophosphate 25-43 interferon gamma Homo sapiens 0-9 2506547-1 1989 Several mutants of the human cell line ME-180 resistant to the cytotoxic effect of interferon gamma (IFN-gamma) were isolated after mutagenesis with nitrosoguanidine. Nitrosoguanidines 149-165 interferon gamma Homo sapiens 83-110 2506547-2 1989 Two of the mutant lines (ME-IR3b and ME-IR6g) examined had significantly lower induction levels of the L-tryptophan (L-Trp) degradative enzyme indoleamine 2,3-dioxygenase activity in response to IFN-gamma. Tryptophan 103-115 interferon gamma Homo sapiens 195-204 2506547-2 1989 Two of the mutant lines (ME-IR3b and ME-IR6g) examined had significantly lower induction levels of the L-tryptophan (L-Trp) degradative enzyme indoleamine 2,3-dioxygenase activity in response to IFN-gamma. Tryptophan 117-122 interferon gamma Homo sapiens 195-204 2506547-3 1989 Moreover, culture medium supplemented with low concentrations of L-Trp reversed the cytotoxic effect of IFN-gamma, whereas higher concentrations of L-Trp in the medium were extremely toxic to both parental and mutant cells. Tryptophan 65-70 interferon gamma Homo sapiens 104-113 2550248-2 1989 We provide evidence that CPZ inhibits the accumulation of mRNA specific for the lymphokines, interleukin 2, interferon-gamma, tumor necrosis factor alpha and the proto-oncogene c-myc; by contrast, the accumulation of mRNA specific for the alpha chain of the interleukin 2 receptor and the subsequent early expression of Tac antigen on the cell surface is not inhibited by CPZ. Chlorpromazine 25-28 interferon gamma Homo sapiens 108-153 2502557-7 1989 These data suggest that IFN gamma may be an important peripleural regulator of macrophage 1,25-(OH)2D synthesis in patients with tuberculous pleuritis and a high pleural fluid 1,25-(OH)2D concentration. 1,25-(oh)2d 90-101 interferon gamma Homo sapiens 24-33 2502557-7 1989 These data suggest that IFN gamma may be an important peripleural regulator of macrophage 1,25-(OH)2D synthesis in patients with tuberculous pleuritis and a high pleural fluid 1,25-(OH)2D concentration. 1,25-(oh)2d 176-187 interferon gamma Homo sapiens 24-33 2502569-1 1989 A patient who for 26 years had common warts, which were resistant to various treatment modalities, was treated with a single intralesional injection of interferon-gamma after dinitrochlorobenzene immunotherapy, because immunologic studies indicated she had failed to respond to prior treatment modalities as a result of a functional impairment of her cellular immune response. Dinitrochlorobenzene 175-195 interferon gamma Homo sapiens 152-168 2528554-2 1989 Recombinant human IFN-gamma was labeled with [gamma-32P]ATP using the catalytic subunit of a cAMP-dependent protein kinase. [gamma-32p]atp 45-59 interferon gamma Homo sapiens 18-27 2528554-2 1989 Recombinant human IFN-gamma was labeled with [gamma-32P]ATP using the catalytic subunit of a cAMP-dependent protein kinase. Cyclic AMP 93-97 interferon gamma Homo sapiens 18-27 2500976-1 1989 Interferon-gamma-induced tryptophan metabolism of human macrophages was compared to ten human neoplastic cell lines of various tissue origin and to normal dermal human fibroblasts. Tryptophan 25-35 interferon gamma Homo sapiens 0-16 2472451-1 1989 FK506, a neutral macrolide with immunosuppressive properties, was shown to selectively and rapidly inhibit the accumulation of IL-2 mRNA, as well as the mRNAs of other early (E) phase T cell activation genes such as IL-3, IL-4, GM-CSF, TNF alpha, IFN-gamma, and c-myc in activated human peripheral blood T cells. Tacrolimus 0-5 interferon gamma Homo sapiens 247-256 2510579-3 1989 Moreover, IFN gamma or the cytotoxic drugs dose-dependently reduced the colony formation of CGL progenitor cell in agar. Agar 115-119 interferon gamma Homo sapiens 10-19 2510579-4 1989 When added in combination, IFN gamma potentiated synergistically the inhibitory action of 5-FU in both systems. Fluorouracil 90-94 interferon gamma Homo sapiens 27-36 2472285-3 1989 The inhibitory effect of the trypsin inhibitors is similar to that of glucocorticoids in that it is a transient event, fading with length of exposure to IFN-gamma, and is reversed by the addition of dibutyryl cyclic AMP (dbcAMP) and phospholipase C(PLC) from Clostridium perfringens. Cyclic AMP 209-219 interferon gamma Homo sapiens 153-162 2472285-3 1989 The inhibitory effect of the trypsin inhibitors is similar to that of glucocorticoids in that it is a transient event, fading with length of exposure to IFN-gamma, and is reversed by the addition of dibutyryl cyclic AMP (dbcAMP) and phospholipase C(PLC) from Clostridium perfringens. Bucladesine 221-227 interferon gamma Homo sapiens 153-162 2472285-4 1989 In H12 cells, dbcAMP and PLC enhance the IFN-gamma induction of HLA-DR, but do not induce in the absence of INF-gamma. Bucladesine 14-20 interferon gamma Homo sapiens 41-50 2503436-3 1989 The accessory cell-derived soluble factor could be replaced by IL-1 and IL-6, and the role of live macrophages for physical interaction with T cells was found to be replaceable with paraformaldehyde(PFA)-fixed macrophages, provided the macrophages were pretreated with interferon-gamma (IFN-gamma) before fixation. Foscarnet 199-202 interferon gamma Homo sapiens 269-285 2503436-3 1989 The accessory cell-derived soluble factor could be replaced by IL-1 and IL-6, and the role of live macrophages for physical interaction with T cells was found to be replaceable with paraformaldehyde(PFA)-fixed macrophages, provided the macrophages were pretreated with interferon-gamma (IFN-gamma) before fixation. Foscarnet 199-202 interferon gamma Homo sapiens 287-296 2787380-2 1989 Peroxide-producing capacity induced by L10 antibody (1.6 +/- 0.3 nmol H2O2/micrograms DNA/h) was comparable with that induced by IFN-gamma (1.3 +/- 0.4 nmol H2O2/micrograms DNA/h), but appeared more rapidly (maximal at 24 h) than in the IFN-gamma-treated monocytes (maximal at 48 h). Peroxides 0-8 interferon gamma Homo sapiens 237-246 2499627-3 1989 Simultaneously exposing leukocytes to 10 mM TAME and either 1000 U/ml IFN-gamma or 10 micrograms/ml LPS reduced the quantity of TNF secreted by 75% and 47%, respectively, when compared with the effect of either IFN-gamma or LPS alone. Tosylarginine Methyl Ester 44-48 interferon gamma Homo sapiens 211-220 2543703-2 1989 Calcitonin gene-related peptide (CGRP), one of the neuropeptides, was found to profoundly inhibit the ability of macrophages to produce H2O2 in response to IFN-gamma or to act as APC. Hydrogen Peroxide 136-140 interferon gamma Homo sapiens 156-165 2472158-6 1989 In MO, IFN-gamma stimulated the OB when co-stimulated with zymosan or PMA. Zymosan 59-66 interferon gamma Homo sapiens 7-16 2472158-6 1989 In MO, IFN-gamma stimulated the OB when co-stimulated with zymosan or PMA. Tetradecanoylphorbol Acetate 70-73 interferon gamma Homo sapiens 7-16 2497971-3 1989 Assessing suspension cultures containing cells from patients with acute myeloid leukemia (11 patients) or myeloid blast crisis of chronic myeloid leukemia (5 patients), it was found that recombinant human TNF-alpha and IFN-gamma significantly enhanced the number of cells reducing nitroblue tetrazolium, as compared to control cultures containing no cytokine (P less than 0.001 and P less than 0.001, respectively). Nitroblue Tetrazolium 281-302 interferon gamma Homo sapiens 219-228 2526700-6 1989 Interferon-gamma decreased MLC TPL activity but increased thymidine incorporation. Thymidine 58-67 interferon gamma Homo sapiens 0-16 2470675-4 1989 That this property of human serum was in large part attributable to the protease inhibitor alpha 2-macroglobulin (alpha 2-M) was suggested by the following observations: (i) methylamine treatment of serum reduced its effect on E, (ii) E interacted directly with alpha 2-M to induce a characteristic conformational change in the protease inhibitor, and (iii) preformed E-alpha 2-M complexes lacked IFN-gamma-degrading activity. methylamine 174-185 interferon gamma Homo sapiens 397-406 2504704-0 1989 Studies on the sugar chains of interferon-gamma from human peripheral-blood lymphocytes. Sugars 15-20 interferon gamma Homo sapiens 31-47 2504704-1 1989 Sugar chains of interferon-gamma (IFN-gamma) from human peripheral-blood lymphocytes (PBL) were liberated by hydrazinolysis. Sugars 0-5 interferon gamma Homo sapiens 16-32 2504704-1 1989 Sugar chains of interferon-gamma (IFN-gamma) from human peripheral-blood lymphocytes (PBL) were liberated by hydrazinolysis. Sugars 0-5 interferon gamma Homo sapiens 34-43 2504704-7 1989 The results showed that IFN-gamma (PBL) contained mono- and disialo-biantennary structures with 0 or 1 mol of fucose residue, as found for IFN-gamma (HBL-38), but the N-acetylneuraminyl alpha 2-6 linkage was dominant in IFN-gamma (PBL), unlike IFN-gamma (HBL-38), which contains both N-acetylneuraminyl alpha 2-3 and alpha 2-6 linkages. Fucose 110-116 interferon gamma Homo sapiens 24-33 2541203-0 1989 IFN-gamma and LPS overcome glucocorticoid inhibition of priming for superoxide release in human monocytes. Superoxides 68-78 interferon gamma Homo sapiens 0-9 2541203-2 1989 We examined the interaction between IFN-gamma, LPS, and glucocorticoids on release of oxygen radicals by human monocytes cultured in vitro. Reactive Oxygen Species 86-101 interferon gamma Homo sapiens 36-45 2541203-4 1989 Monocytes incubated with either IFN-gamma or LPS became "primed" and released greater amounts of O2- in response to stimuli. Superoxides 97-99 interferon gamma Homo sapiens 32-41 2541203-7 1989 When glucocorticoids were co-incubated with IFN-gamma or LPS, the effect of hydrocortisone and other active steroids was blocked, and the monocytes released high O2-. Hydrocortisone 76-90 interferon gamma Homo sapiens 44-53 2541203-7 1989 When glucocorticoids were co-incubated with IFN-gamma or LPS, the effect of hydrocortisone and other active steroids was blocked, and the monocytes released high O2-. Steroids 108-116 interferon gamma Homo sapiens 44-53 2541203-7 1989 When glucocorticoids were co-incubated with IFN-gamma or LPS, the effect of hydrocortisone and other active steroids was blocked, and the monocytes released high O2-. Superoxides 162-164 interferon gamma Homo sapiens 44-53 2541203-8 1989 However, when monocytes were preincubated with hydrocortisone for 24 h before addition of IFN-gamma or LPS, priming for enhanced O2- production by LPS was partially inhibited whereas there was no effect on IFN-gamma priming. Superoxides 129-131 interferon gamma Homo sapiens 90-99 2544801-2 1989 After preincubation of Leydig cells for 24 h with 1000 pM IFN gamma, hCG-stimulated (10 ng/ml, 2 h) testosterone production was inhibited by 50%, whereas no significant changes were seen in hCG-stimulated cAMP production. Testosterone 100-112 interferon gamma Homo sapiens 58-67 2544801-2 1989 After preincubation of Leydig cells for 24 h with 1000 pM IFN gamma, hCG-stimulated (10 ng/ml, 2 h) testosterone production was inhibited by 50%, whereas no significant changes were seen in hCG-stimulated cAMP production. Cyclic AMP 205-209 interferon gamma Homo sapiens 58-67 2544801-3 1989 Incubation with 10 microM 5-cholestene-3 beta,22(R)-diol or 10 microM 5-cholestene-3 beta,20 alpha-diol together with hCG (10 ng/ml, 2 h) reversed most of the inhibitory effect of IFN gamma, suggesting that IFN gamma inhibits P450scc activity, possibly by inhibiting the substrate (cholesterol) availability for P450scc. 5-cholestene-3 beta,22(r)-diol 26-56 interferon gamma Homo sapiens 180-189 2544801-3 1989 Incubation with 10 microM 5-cholestene-3 beta,22(R)-diol or 10 microM 5-cholestene-3 beta,20 alpha-diol together with hCG (10 ng/ml, 2 h) reversed most of the inhibitory effect of IFN gamma, suggesting that IFN gamma inhibits P450scc activity, possibly by inhibiting the substrate (cholesterol) availability for P450scc. 5-cholestene-3 beta,22(r)-diol 26-56 interferon gamma Homo sapiens 207-216 2544801-3 1989 Incubation with 10 microM 5-cholestene-3 beta,22(R)-diol or 10 microM 5-cholestene-3 beta,20 alpha-diol together with hCG (10 ng/ml, 2 h) reversed most of the inhibitory effect of IFN gamma, suggesting that IFN gamma inhibits P450scc activity, possibly by inhibiting the substrate (cholesterol) availability for P450scc. 5-cholestene-3 beta,20 alpha-diol 70-103 interferon gamma Homo sapiens 180-189 2544801-3 1989 Incubation with 10 microM 5-cholestene-3 beta,22(R)-diol or 10 microM 5-cholestene-3 beta,20 alpha-diol together with hCG (10 ng/ml, 2 h) reversed most of the inhibitory effect of IFN gamma, suggesting that IFN gamma inhibits P450scc activity, possibly by inhibiting the substrate (cholesterol) availability for P450scc. 5-cholestene-3 beta,20 alpha-diol 70-103 interferon gamma Homo sapiens 207-216 2544801-4 1989 Incubation with IFN gamma also decreased basal concentrations of P450scc (45%) and P450c 17 (35%) mRNA, although these changes probably did not contribute to the decreased testosterone production. Testosterone 172-184 interferon gamma Homo sapiens 16-25 2544801-6 1989 Simultaneous treatment with IFN gamma attenuated these hCG-induced increases in P450scc mRNA (50%) and P450c 17 mRNA (40-100%) concentrations, as well as in testosterone production (77%). Testosterone 157-169 interferon gamma Homo sapiens 28-37 2544801-8 1989 This suggests that in addition to possible suppression of cholesterol availability, decreased P450scc and/or P450c 17 activities (through decreased mRNA concentrations) were also involved in the IFN gamma suppressed steroidogenic capacity of porcine Leydig cells during long-term hCG stimulation. Cholesterol 58-69 interferon gamma Homo sapiens 195-204 2498883-9 1989 Monoclonal antibody to ICAM-1 precipitated protein of Mr 97,000 from [35S]methionine-labeled islets exposed to IFN-gamma and TNF-alpha, but not from control islets. Methionine 74-84 interferon gamma Homo sapiens 111-120 2544986-2 1989 The effect of gamma interferon (IFN-gamma) on interleukin 1 (IL-1) production by human monocytes induced either by bacterial lipopolysaccharide (LPS) or silica dust was examined. Silicon Dioxide 153-159 interferon gamma Homo sapiens 14-41 2544986-7 1989 In contrast to these data, IFN-gamma had a decreasing effect on IL-1 release by monocytes stimulated with silica dust; in monocyte cultures stimulated with a sub-optimal dose of silica (100 micrograms/ml), only minute amounts of biologically active IL-1 were released in the presence of IFN-gamma. Silicon Dioxide 106-112 interferon gamma Homo sapiens 27-36 2544986-7 1989 In contrast to these data, IFN-gamma had a decreasing effect on IL-1 release by monocytes stimulated with silica dust; in monocyte cultures stimulated with a sub-optimal dose of silica (100 micrograms/ml), only minute amounts of biologically active IL-1 were released in the presence of IFN-gamma. Silicon Dioxide 178-184 interferon gamma Homo sapiens 287-296 2544986-11 1989 In contrast, in silica-stimulated monocytes IFN-gamma reduced the steady-state levels of IL-1 beta mRNA. Silicon Dioxide 16-22 interferon gamma Homo sapiens 44-53 2544989-3 1989 Methylprednisolone down-regulates the IFN-gamma-induced binding, but does not alter the ICAM-1 expression. Methylprednisolone 0-18 interferon gamma Homo sapiens 38-47 2523738-4 1989 While incubation of U937 cells with human interferon-gamma (IFN-gamma) increased Fc gamma RI expression, cholesterol depletion after cell growth in media containing delipidated serum and IFN-gamma resulted in reduced binding of both mAb 32.2 and IgG2a. Cholesterol 105-116 interferon gamma Homo sapiens 42-58 2523738-4 1989 While incubation of U937 cells with human interferon-gamma (IFN-gamma) increased Fc gamma RI expression, cholesterol depletion after cell growth in media containing delipidated serum and IFN-gamma resulted in reduced binding of both mAb 32.2 and IgG2a. Cholesterol 105-116 interferon gamma Homo sapiens 60-69 2523738-4 1989 While incubation of U937 cells with human interferon-gamma (IFN-gamma) increased Fc gamma RI expression, cholesterol depletion after cell growth in media containing delipidated serum and IFN-gamma resulted in reduced binding of both mAb 32.2 and IgG2a. Cholesterol 105-116 interferon gamma Homo sapiens 187-196 2524532-2 1989 Passaged cells have typical macrophage characteristics: they are non-specific esterase positive, phagocytic, and respond to 3 days of treatment with interferon-gamma with enhanced production of superoxide on stimulation with PMA. Superoxides 194-204 interferon gamma Homo sapiens 149-165 2542091-0 1989 The roles of protein kinase C and cyclic nucleotide dependent kinase in signal transduction in human interferon gamma induction by poly I:poly C. Poly I 131-137 interferon gamma Homo sapiens 101-117 2542091-0 1989 The roles of protein kinase C and cyclic nucleotide dependent kinase in signal transduction in human interferon gamma induction by poly I:poly C. Poly C 138-144 interferon gamma Homo sapiens 101-117 2542091-1 1989 The signal transduction mechanisms involved in interferon (IFN) gamma induction in human peripheral mononuclear lymphocyte nylon-nonadherent cells (NNA cells) by stimulation with poly(I):poly(C) are investigated. Poly I 179-186 interferon gamma Homo sapiens 47-69 2542091-1 1989 The signal transduction mechanisms involved in interferon (IFN) gamma induction in human peripheral mononuclear lymphocyte nylon-nonadherent cells (NNA cells) by stimulation with poly(I):poly(C) are investigated. Poly C 187-194 interferon gamma Homo sapiens 47-69 2542091-2 1989 Significant enhancement of IFN gamma production by poly(I):poly(C) is observed in the presence of the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA, a protein kinase C (PKC) activator). Poly I 51-58 interferon gamma Homo sapiens 27-36 2542091-2 1989 Significant enhancement of IFN gamma production by poly(I):poly(C) is observed in the presence of the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA, a protein kinase C (PKC) activator). Poly C 59-66 interferon gamma Homo sapiens 27-36 2542091-2 1989 Significant enhancement of IFN gamma production by poly(I):poly(C) is observed in the presence of the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA, a protein kinase C (PKC) activator). Phorbol Esters 102-115 interferon gamma Homo sapiens 27-36 2542091-2 1989 Significant enhancement of IFN gamma production by poly(I):poly(C) is observed in the presence of the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA, a protein kinase C (PKC) activator). Tetradecanoylphorbol Acetate 117-153 interferon gamma Homo sapiens 27-36 2542091-6 1989 Moreover, inhibition experiments using the PKC inhibitor H-7 and cAMP-dependent protein kinase inhibitor H-8 suggest that the mechanism of signal transduction with regard to PKC is involved in stimulation of IFN gamma production in NNA cells by poly(I):poly(C) in the presence of TPA and that along with PKC, cAMP-dependent protein kinase is probably involved in induction of IFN gamma by stimulation with poly(I):poly(C) alone. Cyclic AMP 65-69 interferon gamma Homo sapiens 208-217 2542091-6 1989 Moreover, inhibition experiments using the PKC inhibitor H-7 and cAMP-dependent protein kinase inhibitor H-8 suggest that the mechanism of signal transduction with regard to PKC is involved in stimulation of IFN gamma production in NNA cells by poly(I):poly(C) in the presence of TPA and that along with PKC, cAMP-dependent protein kinase is probably involved in induction of IFN gamma by stimulation with poly(I):poly(C) alone. Poly I 245-252 interferon gamma Homo sapiens 208-217 2542091-6 1989 Moreover, inhibition experiments using the PKC inhibitor H-7 and cAMP-dependent protein kinase inhibitor H-8 suggest that the mechanism of signal transduction with regard to PKC is involved in stimulation of IFN gamma production in NNA cells by poly(I):poly(C) in the presence of TPA and that along with PKC, cAMP-dependent protein kinase is probably involved in induction of IFN gamma by stimulation with poly(I):poly(C) alone. Poly I 245-252 interferon gamma Homo sapiens 376-385 2542091-6 1989 Moreover, inhibition experiments using the PKC inhibitor H-7 and cAMP-dependent protein kinase inhibitor H-8 suggest that the mechanism of signal transduction with regard to PKC is involved in stimulation of IFN gamma production in NNA cells by poly(I):poly(C) in the presence of TPA and that along with PKC, cAMP-dependent protein kinase is probably involved in induction of IFN gamma by stimulation with poly(I):poly(C) alone. Poly C 253-259 interferon gamma Homo sapiens 208-217 2542091-6 1989 Moreover, inhibition experiments using the PKC inhibitor H-7 and cAMP-dependent protein kinase inhibitor H-8 suggest that the mechanism of signal transduction with regard to PKC is involved in stimulation of IFN gamma production in NNA cells by poly(I):poly(C) in the presence of TPA and that along with PKC, cAMP-dependent protein kinase is probably involved in induction of IFN gamma by stimulation with poly(I):poly(C) alone. Cyclic AMP 309-313 interferon gamma Homo sapiens 208-217 2542091-6 1989 Moreover, inhibition experiments using the PKC inhibitor H-7 and cAMP-dependent protein kinase inhibitor H-8 suggest that the mechanism of signal transduction with regard to PKC is involved in stimulation of IFN gamma production in NNA cells by poly(I):poly(C) in the presence of TPA and that along with PKC, cAMP-dependent protein kinase is probably involved in induction of IFN gamma by stimulation with poly(I):poly(C) alone. Poly I 406-413 interferon gamma Homo sapiens 208-217 2542091-6 1989 Moreover, inhibition experiments using the PKC inhibitor H-7 and cAMP-dependent protein kinase inhibitor H-8 suggest that the mechanism of signal transduction with regard to PKC is involved in stimulation of IFN gamma production in NNA cells by poly(I):poly(C) in the presence of TPA and that along with PKC, cAMP-dependent protein kinase is probably involved in induction of IFN gamma by stimulation with poly(I):poly(C) alone. Poly C 253-260 interferon gamma Homo sapiens 208-217 2502045-1 1989 A protein consisting of human (Hu)-IFN-alpha A to which the COOH-terminal 16 amino acids of Hu-IFN-gamma were fused was prepared by constructing an expression vector by oligonucleotide-directed mutagenesis. Carbonic Acid 60-64 interferon gamma Homo sapiens 95-104 2502045-1 1989 A protein consisting of human (Hu)-IFN-alpha A to which the COOH-terminal 16 amino acids of Hu-IFN-gamma were fused was prepared by constructing an expression vector by oligonucleotide-directed mutagenesis. Oligonucleotides 169-184 interferon gamma Homo sapiens 95-104 2518759-2 1989 Polyacrylamide gel electrophoresis of the resulting product revealed two major components of molecular weight less than that of intact IFN-gamma. polyacrylamide 0-14 interferon gamma Homo sapiens 135-144 2504679-0 1989 Aspirin and thymosin increase interleukin-2 and interferon-gamma production by human peripheral blood lymphocytes. Aspirin 0-7 interferon gamma Homo sapiens 48-64 2504679-5 1989 Peak IFN-gamma production by PHA-stimulated PBLs was observed after 24 h of incubation with TF5 and after 72 h with aspirin. Aspirin 116-123 interferon gamma Homo sapiens 5-14 2504679-8 1989 Oral administration of aspirin in normal volunteers significantly enhanced production of both IFN-gamma and IL-2. Aspirin 23-30 interferon gamma Homo sapiens 94-103 2548970-0 1989 Elevated plasma cortisol levels during interferon-gamma treatment. Hydrocortisone 16-24 interferon gamma Homo sapiens 39-55 2548970-4 1989 Elevated cortisol levels during IFN-gamma treatment may be part of a homeostatic response of the neuroendocrine system to the immunological stimulus induced by IFN-gamma. Hydrocortisone 9-17 interferon gamma Homo sapiens 32-41 2548970-4 1989 Elevated cortisol levels during IFN-gamma treatment may be part of a homeostatic response of the neuroendocrine system to the immunological stimulus induced by IFN-gamma. Hydrocortisone 9-17 interferon gamma Homo sapiens 160-169 2496141-0 1989 Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. Iron 181-185 interferon gamma Homo sapiens 0-16 2504804-0 1989 Calcitriol inhibits the PHA-induced production of IL-2 and IFN-gamma and the proliferation of human peripheral blood leukocytes while enhancing the surface expression of HLA class II molecules. Calcitriol 0-10 interferon gamma Homo sapiens 59-68 2504804-6 1989 After 3 days in culture, 10(-8) M calcitriol strongly inhibited the production of both IL-2 and IFN-gamma. Calcitriol 34-44 interferon gamma Homo sapiens 96-105 2540218-2 1989 Using [3H]proline-labeled cells we found that IFN-gamma resulted in dose-dependent inhibition of fibroblast collagen synthesis. Tritium 7-9 interferon gamma Homo sapiens 46-55 2540218-2 1989 Using [3H]proline-labeled cells we found that IFN-gamma resulted in dose-dependent inhibition of fibroblast collagen synthesis. Proline 10-17 interferon gamma Homo sapiens 46-55 2540220-0 1989 Recombinant interferon-gamma primes alveolar macrophages cultured in vitro for the release of leukotriene B4 in response to IgG stimulation. Leukotriene B4 94-108 interferon gamma Homo sapiens 12-28 2540220-1 1989 The capacity of interferon-gamma to regulate the generation and release of leukotriene B4 (LTB4) from human alveolar macrophages of normal nonsmoking individuals was evaluated. Leukotriene B4 75-89 interferon gamma Homo sapiens 16-32 2501656-5 1989 In addition, phorbol ester-induced differentiation of promyelocytic HL-60 cells and promonocytic THP-1 cells rendered the gamma.1 gene inducible by IFN-gamma. Phorbol Esters 13-26 interferon gamma Homo sapiens 148-157 2786204-3 1989 Purified human monocytes, when stimulated in vitro with lipopolysaccharide (LPS) or with LPS and gamma interferon (IFN-gamma), produce TNF-alpha, IL-1, and PGE2. Dinoprostone 156-160 interferon gamma Homo sapiens 97-124 2495278-1 1989 In this study we report that pretreatment of human amniotic (WISH) cells with interferon gamma (IFN-gamma) in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in the down-modulation of epidermal growth factor (EGF) receptors with respect to both receptor number and affinity. Tetradecanoylphorbol Acetate 126-162 interferon gamma Homo sapiens 78-105 2495278-1 1989 In this study we report that pretreatment of human amniotic (WISH) cells with interferon gamma (IFN-gamma) in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in the down-modulation of epidermal growth factor (EGF) receptors with respect to both receptor number and affinity. Tetradecanoylphorbol Acetate 164-167 interferon gamma Homo sapiens 78-105 2495278-3 1989 Pretreatment with IFN-gamma for 24 h enhanced the TPA-induced inhibition of EGF binding whereas IFN-gamma alone had no effect on binding. Tetradecanoylphorbol Acetate 50-53 interferon gamma Homo sapiens 18-27 2466127-3 1989 Comparative studies of three different Hu-IFNs (IFN-alpha A, IFN-beta ser, and IFN-gamma) revealed that IFN-gamma was the most potent in augmenting either B72.3 or COL-4 binding. Serine 70-73 interferon gamma Homo sapiens 104-113 2494116-3 1989 When IFN-gamma-treated, infected cells were incubated for more extended periods of time before the addition of exogenous tryptophan, no recovery of viable chlamydiae was observed. Tryptophan 121-131 interferon gamma Homo sapiens 5-14 2503497-0 1989 Structures of the sugar chains of interferon-gamma produced by human myelomonocyte cell line HBL-38. Sugars 18-23 interferon gamma Homo sapiens 34-50 2503497-1 1989 Interferon-gamma produced by the human myelomonocyte cell line HBL-38 contained galactose, mannose, fucose, N-acetylglucosamine, and N-acetylneuraminic acid as sugar components. Galactose 80-89 interferon gamma Homo sapiens 0-16 2503497-1 1989 Interferon-gamma produced by the human myelomonocyte cell line HBL-38 contained galactose, mannose, fucose, N-acetylglucosamine, and N-acetylneuraminic acid as sugar components. Mannose 91-98 interferon gamma Homo sapiens 0-16 2503497-1 1989 Interferon-gamma produced by the human myelomonocyte cell line HBL-38 contained galactose, mannose, fucose, N-acetylglucosamine, and N-acetylneuraminic acid as sugar components. Fucose 100-106 interferon gamma Homo sapiens 0-16 2503497-1 1989 Interferon-gamma produced by the human myelomonocyte cell line HBL-38 contained galactose, mannose, fucose, N-acetylglucosamine, and N-acetylneuraminic acid as sugar components. Acetylglucosamine 108-127 interferon gamma Homo sapiens 0-16 2503497-1 1989 Interferon-gamma produced by the human myelomonocyte cell line HBL-38 contained galactose, mannose, fucose, N-acetylglucosamine, and N-acetylneuraminic acid as sugar components. N-Acetylneuraminic Acid 133-156 interferon gamma Homo sapiens 0-16 2503497-1 1989 Interferon-gamma produced by the human myelomonocyte cell line HBL-38 contained galactose, mannose, fucose, N-acetylglucosamine, and N-acetylneuraminic acid as sugar components. Sugars 160-165 interferon gamma Homo sapiens 0-16 2503497-2 1989 Sugar chains were liberated from interferon-gamma by hydrazinolysis. Sugars 0-5 interferon gamma Homo sapiens 33-49 2495301-5 1989 IFN-gamma (1,000 U/ml) reduced [3H]thymidine (TdR) incorporation into DNA by SMC stimulated with the well-defined mitogens IL 1 (from 15.3 +/- 0.7 to 6.2 +/- 0.7 dpm X 10(-3)/24 h) or platelet-derived growth factor (PDGF) (from 18.5 +/- 1.0 to 7.3 +/- 0.7 dpm X 10(-3)/24 h). 3h]thymidine 32-44 interferon gamma Homo sapiens 0-9 2522938-2 1989 The present study was designed to test whether PGE2 might mediate IFN gamma-dependent effects on CD8+ cells by altering the number and/or affinity of their IFN gamma receptors. Dinoprostone 47-51 interferon gamma Homo sapiens 66-75 2522938-2 1989 The present study was designed to test whether PGE2 might mediate IFN gamma-dependent effects on CD8+ cells by altering the number and/or affinity of their IFN gamma receptors. Dinoprostone 47-51 interferon gamma Homo sapiens 156-165 2522938-4 1989 Incubation with 10(-8) M PGE2 for 18 h, however, increased the number of IFN gamma receptors on CD8+ cells without affecting the binding affinity. Dinoprostone 25-29 interferon gamma Homo sapiens 73-82 2522938-7 1989 This observation of a specific stimulatory effect of PGE2 on the display of IFN gamma receptors of CD8+ cells suggests a novel mechanism for eicosanoid function through tissue-specific regulation of hormone receptors. Dinoprostone 53-57 interferon gamma Homo sapiens 76-85 2522938-7 1989 This observation of a specific stimulatory effect of PGE2 on the display of IFN gamma receptors of CD8+ cells suggests a novel mechanism for eicosanoid function through tissue-specific regulation of hormone receptors. Eicosanoids 141-151 interferon gamma Homo sapiens 76-85 2785576-1 1989 Degradation of tryptophan to kynurenine, catalyzed by indoleamine 2,3-dioxygenase (IDO), has been shown previously to be augmented in human peripheral blood mononuclear cells (PBMCs) treated in vitro with interferons-alpha, -beta, and -gamma (IFNs), and in human epithelial cells treated with IFN-gamma. Tryptophan 15-25 interferon gamma Homo sapiens 293-302 2785576-1 1989 Degradation of tryptophan to kynurenine, catalyzed by indoleamine 2,3-dioxygenase (IDO), has been shown previously to be augmented in human peripheral blood mononuclear cells (PBMCs) treated in vitro with interferons-alpha, -beta, and -gamma (IFNs), and in human epithelial cells treated with IFN-gamma. Kynurenine 29-39 interferon gamma Homo sapiens 293-302 2497512-6 1989 Other stimulatory agents, such as gamma interferon (IFN-gamma) and lipopolysaccharide (LPS) showed about half the activity of polyglucose. Glucans 126-137 interferon gamma Homo sapiens 34-61 2493219-0 1989 Escherichia coli-derived human interferon-gamma with Cys-Tyr-Cys at the N-terminus is partially N alpha-acylated. Cys-Tyr-Cys 53-64 interferon gamma Homo sapiens 31-47 2493219-1 1989 Purified preparations of recombinant human interferon-gamma (rIFN-gamma) with Cys-Tyr-Cys at the N-terminus ([ Cys-Tyr-Cys]IFN-gamma) derived from Escherichia coli gave two closely migrating bands on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and two peaks on reversed-phase high-performance liquid chromatography (rpHPLC). Cys-Tyr-Cys 78-89 interferon gamma Homo sapiens 43-59 2493219-1 1989 Purified preparations of recombinant human interferon-gamma (rIFN-gamma) with Cys-Tyr-Cys at the N-terminus ([ Cys-Tyr-Cys]IFN-gamma) derived from Escherichia coli gave two closely migrating bands on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and two peaks on reversed-phase high-performance liquid chromatography (rpHPLC). Cys-Tyr-Cys 78-89 interferon gamma Homo sapiens 62-71 2493219-1 1989 Purified preparations of recombinant human interferon-gamma (rIFN-gamma) with Cys-Tyr-Cys at the N-terminus ([ Cys-Tyr-Cys]IFN-gamma) derived from Escherichia coli gave two closely migrating bands on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and two peaks on reversed-phase high-performance liquid chromatography (rpHPLC). Cys-Tyr-Cys 111-122 interferon gamma Homo sapiens 43-59 2493219-1 1989 Purified preparations of recombinant human interferon-gamma (rIFN-gamma) with Cys-Tyr-Cys at the N-terminus ([ Cys-Tyr-Cys]IFN-gamma) derived from Escherichia coli gave two closely migrating bands on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and two peaks on reversed-phase high-performance liquid chromatography (rpHPLC). Sodium Dodecyl Sulfate 200-222 interferon gamma Homo sapiens 43-59 2493219-1 1989 Purified preparations of recombinant human interferon-gamma (rIFN-gamma) with Cys-Tyr-Cys at the N-terminus ([ Cys-Tyr-Cys]IFN-gamma) derived from Escherichia coli gave two closely migrating bands on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and two peaks on reversed-phase high-performance liquid chromatography (rpHPLC). polyacrylamide 223-237 interferon gamma Homo sapiens 43-59 2493219-1 1989 Purified preparations of recombinant human interferon-gamma (rIFN-gamma) with Cys-Tyr-Cys at the N-terminus ([ Cys-Tyr-Cys]IFN-gamma) derived from Escherichia coli gave two closely migrating bands on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and two peaks on reversed-phase high-performance liquid chromatography (rpHPLC). Sodium Dodecyl Sulfate 259-262 interferon gamma Homo sapiens 43-59 2465168-6 1989 IFN-gamma was a potent inhibitor of G-CSF stimulation: IFN-gamma at 100 U/ml inhibited by greater than 90% the induction of NAP by G-CSF. nap 124-127 interferon gamma Homo sapiens 0-9 2465168-6 1989 IFN-gamma was a potent inhibitor of G-CSF stimulation: IFN-gamma at 100 U/ml inhibited by greater than 90% the induction of NAP by G-CSF. nap 124-127 interferon gamma Homo sapiens 55-64 2465168-8 1989 Furthermore, the simultaneous addition of 10(-6) M retinol partially reversed the inhibitory action of IFN-gamma on the NAP induction by G-CSF. Vitamin A 51-58 interferon gamma Homo sapiens 103-112 2492973-1 1989 To determine whether extracellular tryptophan degradation represents an oxygen-independent antimicrobial mechanism, we examined the effect of exogenous tryptophan on the intracellular antimicrobial activity of gamma interferon (IFN-gamma)-stimulated human macrophages. Tryptophan 152-162 interferon gamma Homo sapiens 210-237 2495247-1 1989 There have been suggestions that the production of pro-inflammatory mediators by human monocytes in response to interferon-gamma (IFN-gamma) may be controlled by changes in prostaglandins. Prostaglandins 173-187 interferon gamma Homo sapiens 112-128 2495247-1 1989 There have been suggestions that the production of pro-inflammatory mediators by human monocytes in response to interferon-gamma (IFN-gamma) may be controlled by changes in prostaglandins. Prostaglandins 173-187 interferon gamma Homo sapiens 130-139 2495247-6 1989 The TNF alpha and IL-1 activities induced by LPS and by LPS with IFN-gamma were reduced by PGE2, and stimulated by indomethacin. Dinoprostone 91-95 interferon gamma Homo sapiens 65-74 2495247-6 1989 The TNF alpha and IL-1 activities induced by LPS and by LPS with IFN-gamma were reduced by PGE2, and stimulated by indomethacin. Indomethacin 115-127 interferon gamma Homo sapiens 65-74 2539325-4 1989 In vitro treatment with recombinant interferon-gamma (rIFN-gamma) caused an enhancement of the capability of AM of inactive sarcoid patients to produce O2- in response to PMA. Oxygen 152-154 interferon gamma Homo sapiens 36-52 2536791-1 1989 Recent studies have shown that in vitro exposure of peripheral blood mononuclear cells (PBMC) to morphine results in suppressed respiratory-burst activity of monocytes and impaired interferon-gamma (IFN-gamma) production by lymphocytes. Morphine 97-105 interferon gamma Homo sapiens 181-197 2536791-1 1989 Recent studies have shown that in vitro exposure of peripheral blood mononuclear cells (PBMC) to morphine results in suppressed respiratory-burst activity of monocytes and impaired interferon-gamma (IFN-gamma) production by lymphocytes. Morphine 97-105 interferon gamma Homo sapiens 199-208 2465309-3 1989 Prednisolone decreased secretion of interferon-gamma by the clones and blocked specific proliferation; the latter could, however, be overcome by the addition of exogenous interleukin 2. Prednisolone 0-12 interferon gamma Homo sapiens 36-52 2524582-4 1989 Because IFN-gamma can influence LPS-stimulated responses, the effect of IFN-gamma on the LPS-stimulated release of PGE2 and IL-1 beta was also assessed. Dinoprostone 115-119 interferon gamma Homo sapiens 72-81 2494657-6 1989 These findings suggest the existence of a phorbol ester-sensitive factor, inducible in MOLT-4 and constitutively expressed or modified in YHHH, which operates in the pathway of induction of class I HLA by IFN-alpha but not in the pathway used by IFN-gamma. Phorbol Esters 42-55 interferon gamma Homo sapiens 246-255 2492206-11 1989 Because the mouse r-IFN-gamma is devoid of direct antitumor effects (against human tumor cells) but is a potent macrophage activator, these results suggest that the antitumor effects were due to direct antitumor effects of FUra and to activation of host defense mechanisms by the r-IFN-gamma. Fluorouracil 223-227 interferon gamma Homo sapiens 20-29 2463903-0 1989 Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma. 1,25-dihydroxyvitamin D 14-37 interferon gamma Homo sapiens 75-91 2463903-4 1989 The production of 1,25-(OH)2D by preconfluent keratinocytes grown in the presence of serum (which retards differentiation) was stimulated by 1.8 nM IFN gamma. 1,25-(oh)2d 18-29 interferon gamma Homo sapiens 148-157 2463903-7 1989 Keratinocytes grown in 0.1 mM calcium serum-free medium (which prevents differentiation) were more sensitive to both the stimulatory and inhibitory effects of IFN gamma than keratinocytes grown in 1.2 mM calcium serum-free medium (which permits differentiation). Calcium 30-37 interferon gamma Homo sapiens 159-168 2463903-7 1989 Keratinocytes grown in 0.1 mM calcium serum-free medium (which prevents differentiation) were more sensitive to both the stimulatory and inhibitory effects of IFN gamma than keratinocytes grown in 1.2 mM calcium serum-free medium (which permits differentiation). Calcium 204-211 interferon gamma Homo sapiens 159-168 2463903-10 1989 The inhibitory effects of IFN gamma on 1,25-(OH)2D production paralleled the inhibitory effects of IFN gamma on cell growth. 1,25-(oh)2d 39-50 interferon gamma Homo sapiens 26-35 2463903-11 1989 Thus, IFN gamma does regulate 1,25-(OH)2D production by keratinocytes. 1,25-(oh)2d 30-41 interferon gamma Homo sapiens 6-15 2494137-0 1989 Interferon gamma-treated human macrophages display enhanced cytolysis and generation of reactive oxygen metabolites but reduced ingestion upon Fc receptor triggering. Oxygen 97-103 interferon gamma Homo sapiens 0-16 2497196-0 1989 Comparison of the inhibitory effects of interferons-alpha and -gamma on testosterone production in porcine Leydig cell culture. Testosterone 72-84 interferon gamma Homo sapiens 40-68 2497196-2 1989 Combined treatment with any of the human IFN-alpha preparations plus recombinant porcine IFN-gamma at the maximal inhibitory dose (1,000 pmoles/liter) further increased the inhibitory effect of any single IFN preparation on hCG-stimulated testosterone production. Testosterone 239-251 interferon gamma Homo sapiens 89-98 2497196-3 1989 These results show that in porcine Leydig cells, both human IFN-alpha and porcine IFN-gamma are able to inhibit testosterone production and that the inhibitory action can be enhanced significantly by combined treatment with these types of IFNs. Testosterone 112-124 interferon gamma Homo sapiens 82-91 2541209-5 1989 The addition of actinomycin D at the time of virus challenge did not substantially affect the induction of the antiviral state against VSV, but markedly retarded the establishment of IFN-gamma-induced antiviral state against Sindbis virus. Dactinomycin 16-29 interferon gamma Homo sapiens 183-192 2493179-4 1989 Both CsA and CsG showed very similar dose-dependent inhibition of IFN-G and LT/TNF activity (IC50 CsA for IFN-G = 8.0 ng/ml, for LT/TNF = 9.5 ng/ml; IC50 CsG for IFN-G = 13.0 ng/ml, for LT/TNF = 13.0 ng/ml). Cyclosporine 5-8 interferon gamma Homo sapiens 66-71 2493179-4 1989 Both CsA and CsG showed very similar dose-dependent inhibition of IFN-G and LT/TNF activity (IC50 CsA for IFN-G = 8.0 ng/ml, for LT/TNF = 9.5 ng/ml; IC50 CsG for IFN-G = 13.0 ng/ml, for LT/TNF = 13.0 ng/ml). Cyclosporine 5-8 interferon gamma Homo sapiens 106-111 2493179-4 1989 Both CsA and CsG showed very similar dose-dependent inhibition of IFN-G and LT/TNF activity (IC50 CsA for IFN-G = 8.0 ng/ml, for LT/TNF = 9.5 ng/ml; IC50 CsG for IFN-G = 13.0 ng/ml, for LT/TNF = 13.0 ng/ml). Cyclosporine 5-8 interferon gamma Homo sapiens 106-111 2493179-4 1989 Both CsA and CsG showed very similar dose-dependent inhibition of IFN-G and LT/TNF activity (IC50 CsA for IFN-G = 8.0 ng/ml, for LT/TNF = 9.5 ng/ml; IC50 CsG for IFN-G = 13.0 ng/ml, for LT/TNF = 13.0 ng/ml). Cyclosporine 98-101 interferon gamma Homo sapiens 106-111 2493179-4 1989 Both CsA and CsG showed very similar dose-dependent inhibition of IFN-G and LT/TNF activity (IC50 CsA for IFN-G = 8.0 ng/ml, for LT/TNF = 9.5 ng/ml; IC50 CsG for IFN-G = 13.0 ng/ml, for LT/TNF = 13.0 ng/ml). Cyclosporine 98-101 interferon gamma Homo sapiens 106-111 2495595-0 1989 The effect of steroids on the production of non-IFN-gamma MHC class II inducing mediators. Steroids 14-22 interferon gamma Homo sapiens 48-57 2481524-8 1989 We have demonstrated that prostaglandins of the E series can significantly reduce the yields of human interferon gamma, but not alpha (the two species of leukocyte derived interferon). Prostaglandins 26-40 interferon gamma Homo sapiens 102-118 2481524-14 1989 Preliminary studies demonstrated that production of human interferon gamma by peripheral blood mononuclear cells was calcium dependent, but production of human interferon alpha was not. Calcium 117-124 interferon gamma Homo sapiens 58-74 2481524-15 1989 Thus, almost all agents studied that influenced calcium dependent intracellular processes influenced the titer of human interferon gamma produced, but not that of human interferon alpha. Calcium 48-55 interferon gamma Homo sapiens 120-136 2492900-1 1989 Retinoic acid alone has no effect on the human breast cancer cell line BT-20 but can amplify the antiproliferative action of interferon-gamma (IFN-gamma). Tretinoin 0-13 interferon gamma Homo sapiens 125-141 2492900-1 1989 Retinoic acid alone has no effect on the human breast cancer cell line BT-20 but can amplify the antiproliferative action of interferon-gamma (IFN-gamma). Tretinoin 0-13 interferon gamma Homo sapiens 143-152 2499421-6 1989 At 0.1 microgram/ml or higher, dexamethasone, hydrocortisone, methylprednisolone and prednisolone significantly (P less than 0.02) inhibited the production of IFN-gamma: respectively 18.9%, 4.4%, 2.2%, and 12.3% of the IFN-gamma produced by MNC in the absence of steroids. Dexamethasone 31-44 interferon gamma Homo sapiens 159-168 2499421-6 1989 At 0.1 microgram/ml or higher, dexamethasone, hydrocortisone, methylprednisolone and prednisolone significantly (P less than 0.02) inhibited the production of IFN-gamma: respectively 18.9%, 4.4%, 2.2%, and 12.3% of the IFN-gamma produced by MNC in the absence of steroids. Dexamethasone 31-44 interferon gamma Homo sapiens 219-228 2499421-6 1989 At 0.1 microgram/ml or higher, dexamethasone, hydrocortisone, methylprednisolone and prednisolone significantly (P less than 0.02) inhibited the production of IFN-gamma: respectively 18.9%, 4.4%, 2.2%, and 12.3% of the IFN-gamma produced by MNC in the absence of steroids. Hydrocortisone 46-60 interferon gamma Homo sapiens 159-168 2499421-6 1989 At 0.1 microgram/ml or higher, dexamethasone, hydrocortisone, methylprednisolone and prednisolone significantly (P less than 0.02) inhibited the production of IFN-gamma: respectively 18.9%, 4.4%, 2.2%, and 12.3% of the IFN-gamma produced by MNC in the absence of steroids. Hydrocortisone 46-60 interferon gamma Homo sapiens 219-228 2499421-6 1989 At 0.1 microgram/ml or higher, dexamethasone, hydrocortisone, methylprednisolone and prednisolone significantly (P less than 0.02) inhibited the production of IFN-gamma: respectively 18.9%, 4.4%, 2.2%, and 12.3% of the IFN-gamma produced by MNC in the absence of steroids. Methylprednisolone 62-80 interferon gamma Homo sapiens 159-168 2499421-6 1989 At 0.1 microgram/ml or higher, dexamethasone, hydrocortisone, methylprednisolone and prednisolone significantly (P less than 0.02) inhibited the production of IFN-gamma: respectively 18.9%, 4.4%, 2.2%, and 12.3% of the IFN-gamma produced by MNC in the absence of steroids. Methylprednisolone 62-80 interferon gamma Homo sapiens 219-228 2499421-6 1989 At 0.1 microgram/ml or higher, dexamethasone, hydrocortisone, methylprednisolone and prednisolone significantly (P less than 0.02) inhibited the production of IFN-gamma: respectively 18.9%, 4.4%, 2.2%, and 12.3% of the IFN-gamma produced by MNC in the absence of steroids. Prednisolone 68-80 interferon gamma Homo sapiens 159-168 2499421-6 1989 At 0.1 microgram/ml or higher, dexamethasone, hydrocortisone, methylprednisolone and prednisolone significantly (P less than 0.02) inhibited the production of IFN-gamma: respectively 18.9%, 4.4%, 2.2%, and 12.3% of the IFN-gamma produced by MNC in the absence of steroids. Prednisolone 68-80 interferon gamma Homo sapiens 219-228 2499421-6 1989 At 0.1 microgram/ml or higher, dexamethasone, hydrocortisone, methylprednisolone and prednisolone significantly (P less than 0.02) inhibited the production of IFN-gamma: respectively 18.9%, 4.4%, 2.2%, and 12.3% of the IFN-gamma produced by MNC in the absence of steroids. Steroids 263-271 interferon gamma Homo sapiens 159-168 2504627-0 1989 Differences in intracellular calcium mobilization by interferon-beta and interferon-gamma in RPMI-4788 cells. Calcium 29-36 interferon gamma Homo sapiens 73-89 2504627-0 1989 Differences in intracellular calcium mobilization by interferon-beta and interferon-gamma in RPMI-4788 cells. rpmi 93-97 interferon gamma Homo sapiens 73-89 2504627-4 1989 The increased [Ca2+]i gradually returned to its resting level within 60 s. The addition of EGTA (0.5-10 mM) to medium induced a marked decrease in the amount of [Ca2+]i mobilized by IFN-beta and a partial decrease by IFN-gamma. Egtazic Acid 91-95 interferon gamma Homo sapiens 217-226 2491828-7 1989 Doxorubicin and IFN-gamma, when used together, acted synergistically against CaSki and SiHa, and in an additive manner against SW 756. sw 756 127-133 interferon gamma Homo sapiens 16-25 2495253-3 1989 Following in vitro exposure to IFN-gamma an increase in NK activity from 36 to 44% (P less than 0.05) could be induced during CsA therapy but this was no longer observed after conversion to AZA (19 to 22%, N.S.). Azathioprine 190-193 interferon gamma Homo sapiens 31-40 2495253-5 1989 The IFN-gamma production capacity after mitogen stimulation of unprimed lymphocytes was more depressed during CsA than during AZA therapy (median 25 vs 80 U/ml 10(6) cells, P less than 0.05), suggesting a reversible inhibition of CsA on lymphokine production. Azathioprine 126-129 interferon gamma Homo sapiens 4-13 2495253-6 1989 Despite the better IFN-gamma production capacity, both the activity, inducibility and number of NK cells were significantly lower under AZA therapy than under CsA therapy. Azathioprine 136-139 interferon gamma Homo sapiens 19-28 2515162-5 1989 At higher concentrations (10 microM) for shorter periods of time (48 h), lovastatin inhibited phytohemagglutin and Concanavalin A-stimulated proliferation by 83% and 38% respectively, natural killer cell cytotoxicity by 93%, and interferon gamma production by 98%. Lovastatin 73-83 interferon gamma Homo sapiens 229-245 2495349-6 1989 Further, a significant positive correlation was observed between serum interferon-gamma and serum neopterin concentrations in seropositive study participants. Neopterin 98-107 interferon gamma Homo sapiens 71-87 2463322-10 1989 Monocyte-derived macrophages were found to retain their capacity to be induced by IFN-gamma and IFN-beta to degrade tryptophan after differentiation, and to possess seven times more IDO activity per cell than IFN-induced monocytes. Tryptophan 116-126 interferon gamma Homo sapiens 82-91 2536064-3 1989 Treatment of EoL-1 with interferon-gamma (IFN-gamma) for 5 days dramatically enhanced TPA-inducible CL, and IFN-alpha A had a similar effect. Tetradecanoylphorbol Acetate 86-89 interferon gamma Homo sapiens 24-40 2536064-3 1989 Treatment of EoL-1 with interferon-gamma (IFN-gamma) for 5 days dramatically enhanced TPA-inducible CL, and IFN-alpha A had a similar effect. Tetradecanoylphorbol Acetate 86-89 interferon gamma Homo sapiens 42-51 2536064-12 1989 It was further demonstrated that treatment of EoL-1 with IFN-gamma and TNF strongly increased the binding sites for phorbol diesters and also dramatically induced the surface expression of fMLP receptors. phorbol 116-123 interferon gamma Homo sapiens 57-66 2518749-0 1989 [Inhibitory effect of recombinant human interferon gamma on human osteoblastic osteosarcoma cells (SaOS2)]. saos2 99-104 interferon gamma Homo sapiens 40-56 2510238-5 1989 Glycolysis, estimated by glucose utilisation and measurements of the glycolytic regulatory metabolite fructose 2,6-bisphosphate was significantly stimulated by TGF beta, IL-1 alpha and IFN-gamma, but less so by TGF alpha. Glucose 25-32 interferon gamma Homo sapiens 185-194 2510238-5 1989 Glycolysis, estimated by glucose utilisation and measurements of the glycolytic regulatory metabolite fructose 2,6-bisphosphate was significantly stimulated by TGF beta, IL-1 alpha and IFN-gamma, but less so by TGF alpha. fructose 2,6-diphosphate 102-127 interferon gamma Homo sapiens 185-194 2510238-6 1989 Prostaglandin E production was significantly increased by IL-1 alpha to an extent much greater than that produced by TGF alpha or TGF beta, although the combined addition of IL-1 alpha with either TGF alpha or beta resulted in a synergistic increase in PGE production, a response partly diminished by the addition of IFN-gamma. Prostaglandins E 0-15 interferon gamma Homo sapiens 317-326 2510332-6 1989 Movement of the EC-bound lymphocyte through the endothelium may be facilitated by IFN-gamma, as suggested by evidence that T cells, bound to the surface of EC monolayers overlying nitrocellulose filters, migrate through these monolayers in increased numbers in the presence of IFN-gamma. ec 16-18 interferon gamma Homo sapiens 82-91 2510332-6 1989 Movement of the EC-bound lymphocyte through the endothelium may be facilitated by IFN-gamma, as suggested by evidence that T cells, bound to the surface of EC monolayers overlying nitrocellulose filters, migrate through these monolayers in increased numbers in the presence of IFN-gamma. ec 16-18 interferon gamma Homo sapiens 277-286 3144968-0 1988 Opposite effect of Interferon-gamma on PGE2 release from Interleukin-1-stimulated human monocytes or fibroblasts. Dinoprostone 39-43 interferon gamma Homo sapiens 19-35 3144968-4 1988 By contrast, an impairement of suppression by IFN-gamma was evidenced in rIL-1 beta-induced PGE2 release from human dermal fibroblasts. Dinoprostone 92-96 interferon gamma Homo sapiens 46-55 2848894-7 1988 2E1 also blocks CIKM5 superoxide production in IFN-gamma-primed monocytes and differentiated U937 cells. cikm5 superoxide 16-32 interferon gamma Homo sapiens 47-56 2464277-6 1988 Culture with IFN alone did not increase PGE2 levels, but potentiated the effect of alpha 2M-proteinase complexes on PGE2 levels. Dinoprostone 116-120 interferon gamma Homo sapiens 13-16 2464277-8 1988 However, exogenous PGE2 did suppress IFN-induced Ia expression. Dinoprostone 19-23 interferon gamma Homo sapiens 37-40 2976621-1 1988 Nickel sulphate antigen-induced peripheral blood lymphocyte activation in vitro was characterized by lymphokine measurement (IL-2, IFN-gamma) and phenotyping of the IL-2 responsive cells. nickel sulfate 0-15 interferon gamma Homo sapiens 131-140 2976621-7 1988 In conclusion, nickel-induced peripheral blood mononuclear cell activation in vitro differs from microbial antigen-induced activation with respect to its modest or non-existent IFN-gamma response. Nickel 15-21 interferon gamma Homo sapiens 177-186 3148378-7 1988 They further demonstrate that, at least in vitro, IFN-gamma, IFN-alpha and LPS can all stimulate neopterin release independently from each other. Neopterin 97-106 interferon gamma Homo sapiens 50-59 3148378-8 1988 Thirdly, they indicate that stimuli such as alloantigens or TNF-alpha can indirectly enhance neopterin release by their capacity to induce production of endogenous IFN-gamma. Neopterin 93-102 interferon gamma Homo sapiens 164-173 2460557-4 1988 Similar treatment of FMEX, an NK-resistant melanoma tumor cell line, with IFN-gamma did not affect its susceptibility to LAK lysis. fmex 21-25 interferon gamma Homo sapiens 74-83 2466090-2 1988 We have found that the production of human (Hu) IFN-gamma is affected significantly by alterations in calcium flux; however, this influence is dependent upon the nature of the compound used to induce IFN. Calcium 102-109 interferon gamma Homo sapiens 48-57 2466090-4 1988 The presence of vitamin D3 reduced IFN-gamma titers when PHA and IL-2 were used to induce IFN, but not when ionomycin was used as the inducer. Cholecalciferol 16-26 interferon gamma Homo sapiens 35-44 2466090-5 1988 The production of IFN-gamma by PBMC was reduced by diminished concentrations in extracellular calcium but not extracellular magnesium. Calcium 94-101 interferon gamma Homo sapiens 18-27 3148005-0 1988 Serotonin and melatonin synthesis in peripheral blood mononuclear cells: stimulation by interferon-gamma as part of an immunomodulatory pathway. Serotonin 0-9 interferon gamma Homo sapiens 88-104 3148005-1 1988 Serotonin and melatonin inhibit phytohemagglutinin- (PHA) induced interferon-gamma (IFN-gamma) production by lymphocytes. Serotonin 0-9 interferon gamma Homo sapiens 66-82 3148005-1 1988 Serotonin and melatonin inhibit phytohemagglutinin- (PHA) induced interferon-gamma (IFN-gamma) production by lymphocytes. Serotonin 0-9 interferon gamma Homo sapiens 84-93 3148005-1 1988 Serotonin and melatonin inhibit phytohemagglutinin- (PHA) induced interferon-gamma (IFN-gamma) production by lymphocytes. Melatonin 14-23 interferon gamma Homo sapiens 66-82 3148005-1 1988 Serotonin and melatonin inhibit phytohemagglutinin- (PHA) induced interferon-gamma (IFN-gamma) production by lymphocytes. Melatonin 14-23 interferon gamma Homo sapiens 84-93 3148005-2 1988 In this paper, it is shown that IFN-gamma-increased tryptophan uptake by lymphocytes and macrophages led to an enhanced production of serotonin. Tryptophan 52-62 interferon gamma Homo sapiens 32-41 3148005-2 1988 In this paper, it is shown that IFN-gamma-increased tryptophan uptake by lymphocytes and macrophages led to an enhanced production of serotonin. Serotonin 134-143 interferon gamma Homo sapiens 32-41 3148005-3 1988 When IFN-gamma and serotonin were added together to a lymphocyte culture, N-acetyl serotonin and melatonin production was increased, whereas the path to 5-hydroxy-indoleacetic acid remained unchanged. N-acetylserotonin 74-92 interferon gamma Homo sapiens 5-14 3148005-3 1988 When IFN-gamma and serotonin were added together to a lymphocyte culture, N-acetyl serotonin and melatonin production was increased, whereas the path to 5-hydroxy-indoleacetic acid remained unchanged. Melatonin 97-106 interferon gamma Homo sapiens 5-14 3148005-3 1988 When IFN-gamma and serotonin were added together to a lymphocyte culture, N-acetyl serotonin and melatonin production was increased, whereas the path to 5-hydroxy-indoleacetic acid remained unchanged. 5-hydroxy-indoleacetic acid 153-180 interferon gamma Homo sapiens 5-14 3148005-4 1988 Therefore, the stimulated IFN-gamma production of serotonin and melatonin by lymphocytes and macrophages and the inhibition of IFN-gamma synthesis by these indoleamines suggest a hypothesis for an immunoregulatory circuit. Serotonin 50-59 interferon gamma Homo sapiens 26-35 3148005-4 1988 Therefore, the stimulated IFN-gamma production of serotonin and melatonin by lymphocytes and macrophages and the inhibition of IFN-gamma synthesis by these indoleamines suggest a hypothesis for an immunoregulatory circuit. Melatonin 64-73 interferon gamma Homo sapiens 26-35 3148005-4 1988 Therefore, the stimulated IFN-gamma production of serotonin and melatonin by lymphocytes and macrophages and the inhibition of IFN-gamma synthesis by these indoleamines suggest a hypothesis for an immunoregulatory circuit. indolamine 156-168 interferon gamma Homo sapiens 127-136 2976521-3 1988 Histamine was shown to suppress to a similar extent the production of interleukin 2 (IL-2) and gamma interferon (IFN-gamma) by Leu 3+, Leu 3+8+, and Leu 3+8- cell subsets. Histamine 0-9 interferon gamma Homo sapiens 95-122 2976521-6 1988 The IFN-gamma production by the Leu 3+ and Leu 3+18- cells and the marginal production by Leu 3+18+ cells were significantly suppressed by histamine. Histamine 139-148 interferon gamma Homo sapiens 4-13 2976521-8 1988 It was shown that the inhibitory effect of histamine on the early production of IL-2 and the major production of IFN-gamma by T helper cells is mediated via action on both the Leu 3+18-8- and the Leu 3+18-8+ cells. Histamine 43-52 interferon gamma Homo sapiens 113-122 2460255-0 1988 Modulation of interferon-gamma-induced major histocompatibility (MHC) and CD14 antigen changes by lipophilic muramyltripeptide MTP-PE in human monocytes. muramyltripeptide 109-126 interferon gamma Homo sapiens 14-30 3052858-1 1988 Previous studies in this laboratory have demonstrated that the adhesion of T lymphocytes to endothelial cell (EC) monolayers in vitro can be increased by preincubation of the EC with interferon-gamma, interleukin 1 (IL-1), tumor necrosis factor-alpha (TNF), or lipopolysaccharide (LPS), or by stimulation of the T cells with phorbol esters. Phorbol Esters 325-339 interferon gamma Homo sapiens 183-199 3139565-6 1988 AP-treated recombinant IFN-gamma showed altered migration on Western blots (immunoblots) of polyacrylamide gels, and this modification correlated with a dose-dependent loss of antiviral activity. polyacrylamide 92-106 interferon gamma Homo sapiens 23-32 3146586-0 1988 Immunomodulation by indoleamines: serotonin and melatonin action on DNA and interferon-gamma synthesis by human peripheral blood mononuclear cells. indolamine 20-32 interferon gamma Homo sapiens 76-92 3146586-0 1988 Immunomodulation by indoleamines: serotonin and melatonin action on DNA and interferon-gamma synthesis by human peripheral blood mononuclear cells. Melatonin 48-57 interferon gamma Homo sapiens 76-92 3146586-6 1988 Serotonin and melatonin also inhibited phytohemagglutinin and protein A from Staphylococcus aureus induction of interferon-gamma synthesis. Serotonin 0-9 interferon gamma Homo sapiens 112-128 3146586-6 1988 Serotonin and melatonin also inhibited phytohemagglutinin and protein A from Staphylococcus aureus induction of interferon-gamma synthesis. Melatonin 14-23 interferon gamma Homo sapiens 112-128 3146586-8 1988 As interferon-gamma induced tryptophan uptake by T lymphocyte- and macrophage-depleted populations, and tryptophan is the metabolic precursor of serotonin and melatonin, a new immunoregulatory circuit is postulated. Tryptophan 28-38 interferon gamma Homo sapiens 3-19 3146586-8 1988 As interferon-gamma induced tryptophan uptake by T lymphocyte- and macrophage-depleted populations, and tryptophan is the metabolic precursor of serotonin and melatonin, a new immunoregulatory circuit is postulated. Serotonin 145-154 interferon gamma Homo sapiens 3-19 3146586-8 1988 As interferon-gamma induced tryptophan uptake by T lymphocyte- and macrophage-depleted populations, and tryptophan is the metabolic precursor of serotonin and melatonin, a new immunoregulatory circuit is postulated. Melatonin 159-168 interferon gamma Homo sapiens 3-19 2850878-3 1988 Neopterin is a low molecular weight product released by human macrophages upon stimulation with interferon gamma. Neopterin 0-9 interferon gamma Homo sapiens 96-112 2466913-1 1988 Human immune interferon-gamma (HuIFN-gamma) labeled with 32P was used to study the structure of IFN-gamma receptor. Phosphorus-32 57-60 interferon gamma Homo sapiens 33-42 2466913-2 1988 When [32P]HuIFN-gamma was bound and crosslinked to IFN-gamma the receptor of human cells with a bifunctional crosslinker disuccinimidyl suberate (DSS), a single diffused 32P-labeled band corresponding to the IFN-gamma.receptor complex was visualized by SDS-polyacrylamide gel electrophoresis and autoradiography. Phosphorus-32 6-9 interferon gamma Homo sapiens 12-21 2466913-2 1988 When [32P]HuIFN-gamma was bound and crosslinked to IFN-gamma the receptor of human cells with a bifunctional crosslinker disuccinimidyl suberate (DSS), a single diffused 32P-labeled band corresponding to the IFN-gamma.receptor complex was visualized by SDS-polyacrylamide gel electrophoresis and autoradiography. Phosphorus-32 6-9 interferon gamma Homo sapiens 51-60 2466913-2 1988 When [32P]HuIFN-gamma was bound and crosslinked to IFN-gamma the receptor of human cells with a bifunctional crosslinker disuccinimidyl suberate (DSS), a single diffused 32P-labeled band corresponding to the IFN-gamma.receptor complex was visualized by SDS-polyacrylamide gel electrophoresis and autoradiography. disuccinimidyl 121-135 interferon gamma Homo sapiens 12-21 2466913-2 1988 When [32P]HuIFN-gamma was bound and crosslinked to IFN-gamma the receptor of human cells with a bifunctional crosslinker disuccinimidyl suberate (DSS), a single diffused 32P-labeled band corresponding to the IFN-gamma.receptor complex was visualized by SDS-polyacrylamide gel electrophoresis and autoradiography. disuccinimidyl 121-135 interferon gamma Homo sapiens 51-60 2466913-2 1988 When [32P]HuIFN-gamma was bound and crosslinked to IFN-gamma the receptor of human cells with a bifunctional crosslinker disuccinimidyl suberate (DSS), a single diffused 32P-labeled band corresponding to the IFN-gamma.receptor complex was visualized by SDS-polyacrylamide gel electrophoresis and autoradiography. disuccinimidyl suberate 146-149 interferon gamma Homo sapiens 12-21 2466913-2 1988 When [32P]HuIFN-gamma was bound and crosslinked to IFN-gamma the receptor of human cells with a bifunctional crosslinker disuccinimidyl suberate (DSS), a single diffused 32P-labeled band corresponding to the IFN-gamma.receptor complex was visualized by SDS-polyacrylamide gel electrophoresis and autoradiography. disuccinimidyl suberate 146-149 interferon gamma Homo sapiens 51-60 2466913-2 1988 When [32P]HuIFN-gamma was bound and crosslinked to IFN-gamma the receptor of human cells with a bifunctional crosslinker disuccinimidyl suberate (DSS), a single diffused 32P-labeled band corresponding to the IFN-gamma.receptor complex was visualized by SDS-polyacrylamide gel electrophoresis and autoradiography. Phosphorus-32 170-173 interferon gamma Homo sapiens 12-21 2466913-2 1988 When [32P]HuIFN-gamma was bound and crosslinked to IFN-gamma the receptor of human cells with a bifunctional crosslinker disuccinimidyl suberate (DSS), a single diffused 32P-labeled band corresponding to the IFN-gamma.receptor complex was visualized by SDS-polyacrylamide gel electrophoresis and autoradiography. Phosphorus-32 170-173 interferon gamma Homo sapiens 51-60 2466913-2 1988 When [32P]HuIFN-gamma was bound and crosslinked to IFN-gamma the receptor of human cells with a bifunctional crosslinker disuccinimidyl suberate (DSS), a single diffused 32P-labeled band corresponding to the IFN-gamma.receptor complex was visualized by SDS-polyacrylamide gel electrophoresis and autoradiography. Sodium Dodecyl Sulfate 253-256 interferon gamma Homo sapiens 12-21 2466913-2 1988 When [32P]HuIFN-gamma was bound and crosslinked to IFN-gamma the receptor of human cells with a bifunctional crosslinker disuccinimidyl suberate (DSS), a single diffused 32P-labeled band corresponding to the IFN-gamma.receptor complex was visualized by SDS-polyacrylamide gel electrophoresis and autoradiography. Sodium Dodecyl Sulfate 253-256 interferon gamma Homo sapiens 51-60 2466913-2 1988 When [32P]HuIFN-gamma was bound and crosslinked to IFN-gamma the receptor of human cells with a bifunctional crosslinker disuccinimidyl suberate (DSS), a single diffused 32P-labeled band corresponding to the IFN-gamma.receptor complex was visualized by SDS-polyacrylamide gel electrophoresis and autoradiography. polyacrylamide 257-271 interferon gamma Homo sapiens 12-21 2466913-2 1988 When [32P]HuIFN-gamma was bound and crosslinked to IFN-gamma the receptor of human cells with a bifunctional crosslinker disuccinimidyl suberate (DSS), a single diffused 32P-labeled band corresponding to the IFN-gamma.receptor complex was visualized by SDS-polyacrylamide gel electrophoresis and autoradiography. polyacrylamide 257-271 interferon gamma Homo sapiens 51-60 2466913-12 1988 The IFN-gamma.receptor complex of placental membranes was solubilized with NP-40 after DSS treatment and partially purified with immobilized antibody to the carboxyl terminus of IFN-gamma. disuccinimidyl suberate 87-90 interferon gamma Homo sapiens 4-13 2466914-3 1988 An increase in O2 consumption after f-MLP-stimulation was seen when PMN had been incubated 2-4 h with either 1000 IU/ml IFN-alpha or 100 IU/ml IFN-gamma, but this increase in O2 consumption was not observed with 1000 IU/ml IFN-beta. Oxygen 15-17 interferon gamma Homo sapiens 143-152 3138195-4 1988 Treatment of FMEX, an NK-resistant melanoma tumor cell line, with IFN-gamma did not affect its susceptibility to LAK lysis. fmex 13-17 interferon gamma Homo sapiens 66-75 2502582-3 1989 Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Poly I 71-78 interferon gamma Homo sapiens 24-33 2502582-3 1989 Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Poly C 79-86 interferon gamma Homo sapiens 24-33 2502582-3 1989 Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Poly I 173-180 interferon gamma Homo sapiens 24-33 2502582-3 1989 Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Poly C 79-85 interferon gamma Homo sapiens 24-33 2500974-3 1989 The synthesis of DNA, as measured by [3H]thymidine incorporation, is stimulated by IFN-gamma. Tritium 38-40 interferon gamma Homo sapiens 83-92 2500974-3 1989 The synthesis of DNA, as measured by [3H]thymidine incorporation, is stimulated by IFN-gamma. Thymidine 41-50 interferon gamma Homo sapiens 83-92 2500974-5 1989 Thus, IFN-gamma opposes the stimulatory effect of IL-1 on caseinase production and decreases IL-1-stimulated cartilage degradation, as measured by glycosaminoglycan release. Glycosaminoglycans 147-164 interferon gamma Homo sapiens 6-15 2500976-3 1989 With the exception of two cell lines (Hep G 2, hepatoma and CaCo 2, colon adenocarcinoma) in all of the ten other cells and cell lines tryptophan degradation was induced by interferon-gamma. Tryptophan 135-145 interferon gamma Homo sapiens 173-189 2500976-11 1989 Though interferon-gamma was the most potent inducer of tryptophan metabolism, interferon-alpha and/or -beta showed small but distinct action on some of the cells. Tryptophan 55-65 interferon gamma Homo sapiens 7-23 2500976-12 1989 In all cells which reacted to interferon-gamma by enhanced expression of class I and/or class II major histocompatibility complex antigens tryptophan degradation was also inducible. Tryptophan 139-149 interferon gamma Homo sapiens 30-46 2500976-13 1989 These results demonstrate that induction of indoleamine 2,3-dioxygenase is a common feature of interferon-gamma action, that the extent of this induction is influenced by extracellular L-tryptophan concentrations and that indoleamine 2,3-dioxygenase is the only enzyme in the formation of 3-hydroxyanthranilic acid from tryptophan which is regulated by interferon-gamma. Tryptophan 185-197 interferon gamma Homo sapiens 95-111 2500976-13 1989 These results demonstrate that induction of indoleamine 2,3-dioxygenase is a common feature of interferon-gamma action, that the extent of this induction is influenced by extracellular L-tryptophan concentrations and that indoleamine 2,3-dioxygenase is the only enzyme in the formation of 3-hydroxyanthranilic acid from tryptophan which is regulated by interferon-gamma. 3-Hydroxyanthranilic Acid 289-314 interferon gamma Homo sapiens 95-111 2500976-13 1989 These results demonstrate that induction of indoleamine 2,3-dioxygenase is a common feature of interferon-gamma action, that the extent of this induction is influenced by extracellular L-tryptophan concentrations and that indoleamine 2,3-dioxygenase is the only enzyme in the formation of 3-hydroxyanthranilic acid from tryptophan which is regulated by interferon-gamma. Tryptophan 187-197 interferon gamma Homo sapiens 95-111 3141208-6 1988 During follow-up of individual patients, an inverse relationship was observed between the haematological response to CS and the levels of activated T-suppressor/cytotoxic cells, IFN-gamma+ lymphocytes (in PB and BM) and NK-like cells (in BM). Cyclosporine 117-119 interferon gamma Homo sapiens 178-187 2977292-4 1988 Suppression of IFN-gamma was significantly greater in 16 male donors (29 +/- 6.0%) compared to 8 female donors (1.5 +/- 6.4%) when PBMNC were preincubated for 3 h with beta-END followed by concanavalin A stimulation for 72 h in medium containing 20% fetal bovine serum (FBS). pbmnc 131-136 interferon gamma Homo sapiens 15-24 2977292-7 1988 This observation provides support for the hypothesis that beta-END achieves its suppressive effect on IFN-gamma via a mechanism involving arachidonic acid metabolism. Arachidonic Acid 138-154 interferon gamma Homo sapiens 102-111 3135415-0 1988 Effect of interferon gamma on tryptophan and pteridine metabolism of human cells. Tryptophan 30-40 interferon gamma Homo sapiens 10-26 3416434-1 1988 Neopterin, a marker of cellular immune system activation, is produced by human macrophages after induction by interferon gamma (secreted by T-lymphocytes) and is eliminated mostly in urine. Neopterin 0-9 interferon gamma Homo sapiens 110-126 2971353-0 1988 Effects of an anti-tumor polysaccharide, schizophyllan, on interferon-gamma and interleukin 2 production by peripheral blood mononuclear cells. Polysaccharides 25-39 interferon gamma Homo sapiens 59-75 2971353-1 1988 We examined the effect of schizophyllan, a neutral glucan isolated from the culture filtrate of Schizophyllum commune Fries, on the production of interferon-gamma (IFN-gamma) and interleukin 2 (IL 2) from the mitogen-stimulated human peripheral blood mononuclear cells (PBMC). Sizofiran 26-39 interferon gamma Homo sapiens 146-162 2971353-1 1988 We examined the effect of schizophyllan, a neutral glucan isolated from the culture filtrate of Schizophyllum commune Fries, on the production of interferon-gamma (IFN-gamma) and interleukin 2 (IL 2) from the mitogen-stimulated human peripheral blood mononuclear cells (PBMC). Sizofiran 26-39 interferon gamma Homo sapiens 164-173 2971353-3 1988 These results suggest that the increased production of IFN-gamma and IL 2 may be responsible for the anti-tumor activity of this glucan. Glucans 129-135 interferon gamma Homo sapiens 55-64 3135327-2 1988 Monocytes activated by IFN-gamma bound an average of 2 x 10(6) DR-specific mAb, 3 x 10(5) DQ-specific mAb, and 7 x 10(5) DP-specific mAb per cell. dp 121-123 interferon gamma Homo sapiens 23-32 3135332-5 1988 In combination with IFN-gamma, the daunomycin-mAb CL 207 conjugate displays a selective in vitro and in vivo toxic effect on tumor cells that express the 96-kDa MAA. Daunorubicin 35-45 interferon gamma Homo sapiens 20-29 3135415-0 1988 Effect of interferon gamma on tryptophan and pteridine metabolism of human cells. Pteridines 45-54 interferon gamma Homo sapiens 10-26 2456335-0 1988 High affinity human IFN-gamma-binding capacity is encoded by a single receptor gene located in proximity to c-ros on human chromosome region 6q16 to 6q22. ros 110-113 interferon gamma Homo sapiens 20-29 2969394-3 1988 PBL, stimulated with Con A or with a combination of the phorbol ester 13-O-tetradecanoylphorbol-12-acetate and the Ca2+ ionophore A23187 secreted IL-2, IL-4, and IFN-gamma. Pentane-2,2,4,4-Tetrol 0-3 interferon gamma Homo sapiens 162-171 3135942-7 1988 Oxidation of galactose residues on glycoproteins of macrophage membrane is an obligate step for IFN-gamma induction whatever the inducer, thus our results suggest that beta 2m is involved in the mechanism of induction of IFN-gamma. Galactose 13-22 interferon gamma Homo sapiens 96-105 3135942-7 1988 Oxidation of galactose residues on glycoproteins of macrophage membrane is an obligate step for IFN-gamma induction whatever the inducer, thus our results suggest that beta 2m is involved in the mechanism of induction of IFN-gamma. Galactose 13-22 interferon gamma Homo sapiens 221-230 2969394-3 1988 PBL, stimulated with Con A or with a combination of the phorbol ester 13-O-tetradecanoylphorbol-12-acetate and the Ca2+ ionophore A23187 secreted IL-2, IL-4, and IFN-gamma. phorbol ester 13-o-tetradecanoylphorbol-12-acetate 56-106 interferon gamma Homo sapiens 162-171 2969394-3 1988 PBL, stimulated with Con A or with a combination of the phorbol ester 13-O-tetradecanoylphorbol-12-acetate and the Ca2+ ionophore A23187 secreted IL-2, IL-4, and IFN-gamma. Calcimycin 130-136 interferon gamma Homo sapiens 162-171 3139787-1 1988 We have reported that human interferon-gamma (IFN-gamma) genomic DNA is expressed after transfection into a mouse T-lymphoblastoid cell line and expression can be enhanced by both interleukin 2 (IL2) and phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 231-234 interferon gamma Homo sapiens 28-44 3139787-0 1988 Characterization of interleukin 2 and phorbol myristate acetate augmentation of expression of transfected human interferon-gamma genomic DNA. Tetradecanoylphorbol Acetate 38-63 interferon gamma Homo sapiens 112-128 3139787-1 1988 We have reported that human interferon-gamma (IFN-gamma) genomic DNA is expressed after transfection into a mouse T-lymphoblastoid cell line and expression can be enhanced by both interleukin 2 (IL2) and phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 231-234 interferon gamma Homo sapiens 46-55 3139787-1 1988 We have reported that human interferon-gamma (IFN-gamma) genomic DNA is expressed after transfection into a mouse T-lymphoblastoid cell line and expression can be enhanced by both interleukin 2 (IL2) and phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 204-229 interferon gamma Homo sapiens 28-44 3139787-1 1988 We have reported that human interferon-gamma (IFN-gamma) genomic DNA is expressed after transfection into a mouse T-lymphoblastoid cell line and expression can be enhanced by both interleukin 2 (IL2) and phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 204-229 interferon gamma Homo sapiens 46-55 3139787-5 1988 Stimulation of IFN-gamma mRNA by both PMA and IL2 could occur in the presence of cycloheximide, indicating that protein synthesis was not required for the initial stimulation to occur. Cycloheximide 81-94 interferon gamma Homo sapiens 15-24 3139787-6 1988 However, the functional half-life of IFN-gamma mRNA after actinomycin D treatment was higher in cells that had been treated with PMA when compared with untreated or IL2-treated cells. Dactinomycin 58-71 interferon gamma Homo sapiens 37-46 2968406-1 1988 A synthetic 17 amino acid peptide (CKS-17) homologous to a highly conserved region of human and animal retroviral transmembrane proteins was investigated for its influence on the in vitro production of IFN-gamma from human peripheral mononuclear cells. 17 amino acid peptide 12-33 interferon gamma Homo sapiens 202-211 3138247-4 1988 In the present study, we have used fluorescence photobleaching recovery (FPR) to quantify the effects of the cytokines tumor necrosis factor (TNF) and immune interferon (IFN-gamma) on the lateral mobilities of class I major histocompatibility complex protein, of an abundant 96,000 Mr mesenchymal cell surface glycoprotein (gp96), and of a phospholipid probe in cultured human endothelial cell (HEC) membranes. Phospholipids 340-352 interferon gamma Homo sapiens 170-179 2968406-6 1988 The inhibition appeared to be a direct effect of CKS-17 on IFN-gamma-producing cells. CKS 17 49-55 interferon gamma Homo sapiens 59-68 2843076-3 1988 While the enzyme activity was reduced after cultivation of the cells with recombinant interferon-gamma (gamma-IFN) in all of the groups studied, the percentage reduction was significantly greater in monocytes from patients with active relapsing MS who were in relapse at the time of sampling (p = 0.03). gamma-ifn 104-113 interferon gamma Homo sapiens 86-102 3139552-3 1988 The anti-thyroid drug methimazole was capable of rapidly reducing Graves" IgG-induced DR expression but to a much lesser extent than brought about by interferon-gamma. Methimazole 22-33 interferon gamma Homo sapiens 150-166 2455298-3 1988 Two protocols were followed to purify the IFN-gamma receptor from octyl glucoside-solubilized membranes: (i) sequential affinity chromatography over wheat germ agglutinin- and IFN-gamma-Sepharose and (ii) affinity chromatography over columns containing receptor-specific monoclonal antibody and wheat germ agglutinin. octyl-beta-D-glucoside 66-81 interferon gamma Homo sapiens 42-51 2839835-2 1988 Interferon gamma has been shown to augment phagocyte superoxide production, but the molecular mechanisms underlying this effect have remained unknown. Superoxides 53-63 interferon gamma Homo sapiens 0-16 2455298-3 1988 Two protocols were followed to purify the IFN-gamma receptor from octyl glucoside-solubilized membranes: (i) sequential affinity chromatography over wheat germ agglutinin- and IFN-gamma-Sepharose and (ii) affinity chromatography over columns containing receptor-specific monoclonal antibody and wheat germ agglutinin. Sepharose 186-195 interferon gamma Homo sapiens 42-51 3133656-3 1988 Treatment with the protein synthesis inhibitor, cycloheximide, abolishes the IFN-gamma-induced accumulation of HLA-DR alpha mRNA, indicating that de novo synthesis of a trans-acting protein factor is required for induction of this major histocompatibility complex class II gene. Cycloheximide 48-61 interferon gamma Homo sapiens 77-86 3133656-6 1988 IFN-gamma-induced transcription of HLA-DR alpha and of the invariant chain gene was blocked by treatment with cycloheximide, but IFN-gamma-induced transcription of HLA-A2 was unaffected. Cycloheximide 110-123 interferon gamma Homo sapiens 0-9 2455298-3 1988 Two protocols were followed to purify the IFN-gamma receptor from octyl glucoside-solubilized membranes: (i) sequential affinity chromatography over wheat germ agglutinin- and IFN-gamma-Sepharose and (ii) affinity chromatography over columns containing receptor-specific monoclonal antibody and wheat germ agglutinin. Sepharose 186-195 interferon gamma Homo sapiens 176-185 2455298-5 1988 Purified receptor migrated as a single molecular species of 90 kDa either when analyzed on silver-stained NaDodSO4/polyacrylamide gels or when subjected to electrophoretic transfer blot analysis using a labeled IFN-gamma receptor-specific monoclonal antibody. nadodso4 106-114 interferon gamma Homo sapiens 211-220 3134657-5 1988 Two selective inhibitors of PKC, H7 and sphingosine, suppressed not only the induction of gamma.1 mRNA but transcription of HLA-DR by IFN-gamma as well. Sphingosine 40-51 interferon gamma Homo sapiens 134-143 2455298-6 1988 The identity of the 90-kDa component as the receptor was confirmed by demonstrating its ability to specifically bind 125I-labeled IFN-gamma following NaDodSO4/PAGE and transfer to nitrocellulose. nadodso4 150-158 interferon gamma Homo sapiens 130-139 2455298-7 1988 Certain receptor preparations converted into a 55-kDa fragment either during purification or upon storage at 4 degrees C. On the basis of N-Glycanase digestion studies, the IFN-gamma receptor appeared to contain 17 kDa of N-linked carbohydrate. n-linked carbohydrate 222-243 interferon gamma Homo sapiens 173-182 3134021-6 1988 Labeling of newly synthesized receptors with [35S]-methionine indicated that a reduction in the biosynthesis might account for the decrease in the total number of transferrin receptors in IFN gamma-treated cells. Sulfur-35 46-49 interferon gamma Homo sapiens 188-197 3134021-6 1988 Labeling of newly synthesized receptors with [35S]-methionine indicated that a reduction in the biosynthesis might account for the decrease in the total number of transferrin receptors in IFN gamma-treated cells. Methionine 51-61 interferon gamma Homo sapiens 188-197 3134021-7 1988 Our results suggest that the antigrowth effect of IFN gamma is at least partly due to its inhibitory action on transferrin receptor expression leading to iron starvation. Iron 154-158 interferon gamma Homo sapiens 50-59 3137275-7 1988 Like erythromycin and rifampin, clindamycin, which is highly concentrated in human alveolar macrophages, was capable of inhibiting the intracellular multiplication of L. pneumophila but failed to kill the bacteria in nonactivated or IFN-gamma-activated monocytes. Clindamycin 32-43 interferon gamma Homo sapiens 233-242 2454243-4 1988 Furthermore, the proliferation of these cells, as evidenced by nuclear labeling of bromodeoxyuridine (an analog of thymidine that is incorporated into cells in S phase), was markedly reduced, in a dose-dependent manner, by IFN-gamma. Bromodeoxyuridine 83-100 interferon gamma Homo sapiens 223-232 2454243-4 1988 Furthermore, the proliferation of these cells, as evidenced by nuclear labeling of bromodeoxyuridine (an analog of thymidine that is incorporated into cells in S phase), was markedly reduced, in a dose-dependent manner, by IFN-gamma. Thymidine 115-124 interferon gamma Homo sapiens 223-232 2452894-8 1988 When cells are treated with IFN-alpha or IFN-gamma in the presence of cycloheximide, and actinomycin D is added prior to the removal of the cycloheximide, the cells produce the IFN-induced 56,000-dalton protein and develop an antiviral state in response to both IFN-alpha and IFN-gamma. Cycloheximide 70-83 interferon gamma Homo sapiens 41-50 2452894-8 1988 When cells are treated with IFN-alpha or IFN-gamma in the presence of cycloheximide, and actinomycin D is added prior to the removal of the cycloheximide, the cells produce the IFN-induced 56,000-dalton protein and develop an antiviral state in response to both IFN-alpha and IFN-gamma. Cycloheximide 70-83 interferon gamma Homo sapiens 276-285 2452894-8 1988 When cells are treated with IFN-alpha or IFN-gamma in the presence of cycloheximide, and actinomycin D is added prior to the removal of the cycloheximide, the cells produce the IFN-induced 56,000-dalton protein and develop an antiviral state in response to both IFN-alpha and IFN-gamma. Dactinomycin 89-102 interferon gamma Homo sapiens 41-50 2452894-8 1988 When cells are treated with IFN-alpha or IFN-gamma in the presence of cycloheximide, and actinomycin D is added prior to the removal of the cycloheximide, the cells produce the IFN-induced 56,000-dalton protein and develop an antiviral state in response to both IFN-alpha and IFN-gamma. Dactinomycin 89-102 interferon gamma Homo sapiens 276-285 2452894-8 1988 When cells are treated with IFN-alpha or IFN-gamma in the presence of cycloheximide, and actinomycin D is added prior to the removal of the cycloheximide, the cells produce the IFN-induced 56,000-dalton protein and develop an antiviral state in response to both IFN-alpha and IFN-gamma. Cycloheximide 140-153 interferon gamma Homo sapiens 41-50 2452894-8 1988 When cells are treated with IFN-alpha or IFN-gamma in the presence of cycloheximide, and actinomycin D is added prior to the removal of the cycloheximide, the cells produce the IFN-induced 56,000-dalton protein and develop an antiviral state in response to both IFN-alpha and IFN-gamma. Cycloheximide 140-153 interferon gamma Homo sapiens 276-285 3137203-2 1988 Whereas hemmagglutinating virus of Japan (HVJ) enhanced the production of IFN-alpha, bacterial lipopolysaccharide (LPS) markedly enhanced the production of IFN-gamma. bacterial lipopolysaccharide 85-113 interferon gamma Homo sapiens 156-165 2463698-5 1988 In addition, enhanced expression of the antigens on PLC-PRF-5 cells treated with 5-azaC in combination with IFN-gamma or DMSO represented a synergistic effect of these inducers on HLA class I antigens expression although no changes in HLA antigens expression were induced after 5-azaC-treatment alone in short-term experiments. Azacitidine 278-284 interferon gamma Homo sapiens 108-117 3131438-5 1988 We describe the effect of different time and temperature incubations of FITC-labeled cells on fluorescence intensity, and we use the method to analyze the binding of peripheral blood mononuclear leukocytes to interferon-gamma-treated keratinocytes. Fluorescein-5-isothiocyanate 72-76 interferon gamma Homo sapiens 209-225 2838524-3 1988 The treatment with IFN gamma increased this rate two- to threefold when phorbol myristate acetate (PMA) was used as the stimulus. Tetradecanoylphorbol Acetate 72-97 interferon gamma Homo sapiens 19-28 2838524-3 1988 The treatment with IFN gamma increased this rate two- to threefold when phorbol myristate acetate (PMA) was used as the stimulus. Tetradecanoylphorbol Acetate 99-102 interferon gamma Homo sapiens 19-28 2838524-5 1988 At optimum concentrations, f-Met-Leu-Phe elicited rates of superoxide formation that could not be exceeded under other stimulatory conditions including PMA after treatment with IFN gamma. N-Formylmethionine Leucyl-Phenylalanine 27-40 interferon gamma Homo sapiens 177-186 2839459-1 1988 We have examined the potential of IFN-gamma to ameliorate the physiologic defect of CGD by studying its effects on CGD phagocyte superoxide generation, NADPH-oxidase kinetics, and expression of the gene for the phagocyte cytochrome b heavy chain. Superoxides 129-139 interferon gamma Homo sapiens 34-43 2839459-5 1988 All subjects whose phagocytes had responded in vitro showed complete or partial correction of the CGD defect in superoxide generation for up to 1 month after IFN-gamma administration. Superoxides 112-122 interferon gamma Homo sapiens 158-167 3129507-12 1988 Hence, GM-CSF, PGE, and other pharmacologic agents that act to increase intracellular levels of cAMP may play a modulatory role, antagonistic to that of IFN-gamma on cellular expression of IL-2R by human inflammatory macrophages in vivo. Prostaglandins E 15-18 interferon gamma Homo sapiens 153-162 2967768-3 1988 Scatchard analysis of 125I-labeled IgE binding curves revealed that treatment with IFN-gamma increased the number of Fc epsilon RII but did not change the value of the association constant of Fc epsilon RII for 125I-labeled IgE. Iodine-125 22-26 interferon gamma Homo sapiens 83-92 2452208-2 1988 The activation of PBML by phorbol esters (5 to 100 ng/ml) for brief periods of time (5 min to 1 h) at 37 degrees C led to an increase in the relative percentage of adherence to IFN-gamma-treated keratinocytes from 15% for non-activated PBML to 30% for phorbol ester-treated PBML. pbml 18-22 interferon gamma Homo sapiens 177-186 2452208-2 1988 The activation of PBML by phorbol esters (5 to 100 ng/ml) for brief periods of time (5 min to 1 h) at 37 degrees C led to an increase in the relative percentage of adherence to IFN-gamma-treated keratinocytes from 15% for non-activated PBML to 30% for phorbol ester-treated PBML. Phorbol Esters 26-40 interferon gamma Homo sapiens 177-186 2452208-2 1988 The activation of PBML by phorbol esters (5 to 100 ng/ml) for brief periods of time (5 min to 1 h) at 37 degrees C led to an increase in the relative percentage of adherence to IFN-gamma-treated keratinocytes from 15% for non-activated PBML to 30% for phorbol ester-treated PBML. pbml 236-240 interferon gamma Homo sapiens 177-186 2452208-2 1988 The activation of PBML by phorbol esters (5 to 100 ng/ml) for brief periods of time (5 min to 1 h) at 37 degrees C led to an increase in the relative percentage of adherence to IFN-gamma-treated keratinocytes from 15% for non-activated PBML to 30% for phorbol ester-treated PBML. Phorbol Esters 26-39 interferon gamma Homo sapiens 177-186 2452208-2 1988 The activation of PBML by phorbol esters (5 to 100 ng/ml) for brief periods of time (5 min to 1 h) at 37 degrees C led to an increase in the relative percentage of adherence to IFN-gamma-treated keratinocytes from 15% for non-activated PBML to 30% for phorbol ester-treated PBML. pbml 236-240 interferon gamma Homo sapiens 177-186 2966196-5 1988 Experiments with 125I-labeled IFN-gamma showed a relatively small degree of specific binding to these T cell lines. Iodine-125 17-21 interferon gamma Homo sapiens 30-39 2966197-6 1988 Similarly, DEX significantly reduced the IFN-gamma stimulation of ADCC and phagocytosis. Dexamethasone 11-14 interferon gamma Homo sapiens 41-50 2896072-4 1988 The addition of phorbol myristic acetate (PMA), which is not stimulatory by itself, can enhance the synergistic effect of mAb on IFN-gamma production. phorbol myristic acetate 16-40 interferon gamma Homo sapiens 129-138 2896072-4 1988 The addition of phorbol myristic acetate (PMA), which is not stimulatory by itself, can enhance the synergistic effect of mAb on IFN-gamma production. Tetradecanoylphorbol Acetate 42-45 interferon gamma Homo sapiens 129-138 2834451-7 1988 Pretreatment with vitamin D3 followed by IFN-gamma stimulation resulted in a 147% increase in C2 mRNA content compared with IFN-gamma stimulation alone. Cholecalciferol 18-28 interferon gamma Homo sapiens 124-133 2452208-5 1988 Both reduction in temperature to 4 degrees C and preincubation of the phorbol ester-treated PBML with anti-LFA-1 monoclonal antibody, led to complete inhibition of this adherence reaction indicating a role for the LFA-1 molecule in phorbol ester-activated PBML/IFN-gamma-treated keratinocyte reactions. Phorbol Esters 70-83 interferon gamma Homo sapiens 261-270 2452208-7 1988 These results suggest that phorbol ester-activated PBML binds twice greater than resting PBML to IFN-gamma-treated keratinocytes, and this increased adherence may further contribute to homing of activated lymphocytes to the epidermis and mononuclear cell trafficking in the skin of inflammatory dermatoses. Phorbol Esters 27-40 interferon gamma Homo sapiens 97-106 3129525-3 1988 The anti-toxoplasmic effect of culture supernatants correlated with the induction of indoleamine 2,3-dioxygenase and the destruction of tryptophan, as previously described for fibroblasts treated with recombinant gamma interferon (IFN-gamma). Tryptophan 136-146 interferon gamma Homo sapiens 213-240 2966398-0 1988 Calcium influx and the Ca2+-calmodulin complex are involved in interferon-gamma-induced expression of HLA class II molecules on HL-60 cells. Calcium 0-7 interferon gamma Homo sapiens 63-79 3136118-2 1988 In this study, the avarol caused induction of gamma-interferon (IFN-gamma) in buffy coat cells (human peripheral blood lymphocytes) is demonstrated by immunological and molecular biological techniques. avarol 19-25 interferon gamma Homo sapiens 64-73 2966398-9 1988 These results suggest that IFN-gamma stimulates calcium influx by a so-called receptor-mediated calcium channel and activates the calmodulin branch of the calcium messenger system, resulting in the induction of DR molecules on the surface of HL-60 cells. Calcium 48-55 interferon gamma Homo sapiens 27-36 3136118-3 1988 IFN-gamma production was detected after a 24-hr incubation period with avarol; maximal production was obtained after 5 days in the presence of the optimal avarol concentration of 0.75 microgram/ml. avarol 71-77 interferon gamma Homo sapiens 0-9 3136118-3 1988 IFN-gamma production was detected after a 24-hr incubation period with avarol; maximal production was obtained after 5 days in the presence of the optimal avarol concentration of 0.75 microgram/ml. avarol 155-161 interferon gamma Homo sapiens 0-9 3136118-5 1988 Already after a 24-hr incubation with avarol, IFN-gamma gene induction was detected, and maximal induction was found after a 5-day incubation period. avarol 38-44 interferon gamma Homo sapiens 46-55 2966398-9 1988 These results suggest that IFN-gamma stimulates calcium influx by a so-called receptor-mediated calcium channel and activates the calmodulin branch of the calcium messenger system, resulting in the induction of DR molecules on the surface of HL-60 cells. Calcium 96-103 interferon gamma Homo sapiens 27-36 2966398-7 1988 In fact, IFN-gamma evoked a calcium influx into HL-60 cells, whereas depletion of Ca2+ from culture medium resulted in a failure of IFN-gamma to induce DR expression. Calcium 28-35 interferon gamma Homo sapiens 9-18 3127096-5 1988 Preincubation of PBM prior to the addition of inducer mitogen resulted in enhanced IFN-gamma production in patients with Crohn"s disease or ulcerative colitis which significantly exceeded that seen either in healthy controls or in the disease-control group. pbm 17-20 interferon gamma Homo sapiens 83-92 2456740-0 1988 Dual biological activity of apurinic acid on human lymphocytes: induction of interferon-gamma and protection from human immunodeficiency virus infection in vitro. Apurinic Acid 28-41 interferon gamma Homo sapiens 77-93 3260210-1 1988 Neopterin is produced in large amounts specifically from macrophages upon stimulation with interferon-gamma (IFN-gamma). Neopterin 0-9 interferon gamma Homo sapiens 91-107 3260210-1 1988 Neopterin is produced in large amounts specifically from macrophages upon stimulation with interferon-gamma (IFN-gamma). Neopterin 0-9 interferon gamma Homo sapiens 109-118 2450916-2 1988 For example, expression and functional activity of the high affinity FcR for IgG on human mononuclear phagocytes (FcR gamma I) is increased by IFN-gamma and is maximal after co-treatment with IFN-gamma plus the glucocorticoid dexamethasone (DEX). Dexamethasone 226-239 interferon gamma Homo sapiens 143-152 2450916-2 1988 For example, expression and functional activity of the high affinity FcR for IgG on human mononuclear phagocytes (FcR gamma I) is increased by IFN-gamma and is maximal after co-treatment with IFN-gamma plus the glucocorticoid dexamethasone (DEX). Dexamethasone 226-239 interferon gamma Homo sapiens 192-201 2450916-2 1988 For example, expression and functional activity of the high affinity FcR for IgG on human mononuclear phagocytes (FcR gamma I) is increased by IFN-gamma and is maximal after co-treatment with IFN-gamma plus the glucocorticoid dexamethasone (DEX). Dexamethasone 241-244 interferon gamma Homo sapiens 143-152 2450916-2 1988 For example, expression and functional activity of the high affinity FcR for IgG on human mononuclear phagocytes (FcR gamma I) is increased by IFN-gamma and is maximal after co-treatment with IFN-gamma plus the glucocorticoid dexamethasone (DEX). Dexamethasone 241-244 interferon gamma Homo sapiens 192-201 3132511-1 1988 A23187 in combination with phorbol myristate acetate (PMA) strongly induces production of interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC) and even by murine PBMC, which respond poorly to A23187 alone. Calcimycin 0-6 interferon gamma Homo sapiens 90-106 3132511-1 1988 A23187 in combination with phorbol myristate acetate (PMA) strongly induces production of interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC) and even by murine PBMC, which respond poorly to A23187 alone. Calcimycin 0-6 interferon gamma Homo sapiens 108-117 3132511-1 1988 A23187 in combination with phorbol myristate acetate (PMA) strongly induces production of interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC) and even by murine PBMC, which respond poorly to A23187 alone. Tetradecanoylphorbol Acetate 27-52 interferon gamma Homo sapiens 90-106 3132511-1 1988 A23187 in combination with phorbol myristate acetate (PMA) strongly induces production of interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC) and even by murine PBMC, which respond poorly to A23187 alone. Tetradecanoylphorbol Acetate 27-52 interferon gamma Homo sapiens 108-117 3132511-1 1988 A23187 in combination with phorbol myristate acetate (PMA) strongly induces production of interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC) and even by murine PBMC, which respond poorly to A23187 alone. Tetradecanoylphorbol Acetate 54-57 interferon gamma Homo sapiens 90-106 3132511-1 1988 A23187 in combination with phorbol myristate acetate (PMA) strongly induces production of interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC) and even by murine PBMC, which respond poorly to A23187 alone. Tetradecanoylphorbol Acetate 54-57 interferon gamma Homo sapiens 108-117 3132511-1 1988 A23187 in combination with phorbol myristate acetate (PMA) strongly induces production of interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC) and even by murine PBMC, which respond poorly to A23187 alone. Calcimycin 219-225 interferon gamma Homo sapiens 90-106 3132511-1 1988 A23187 in combination with phorbol myristate acetate (PMA) strongly induces production of interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC) and even by murine PBMC, which respond poorly to A23187 alone. Calcimycin 219-225 interferon gamma Homo sapiens 108-117 3127240-0 1988 Human interferon-gamma lacking 23 COOH-terminal amino acids is biologically active. Carbonic Acid 34-38 interferon gamma Homo sapiens 6-22 2453458-6 1988 The enhancement of IL-2 production due to IFN-gamma was more marked in cultures which did not include indomethacin than in cultures which contained indomethacin (1 x 10(-6) M). Indomethacin 102-114 interferon gamma Homo sapiens 42-51 2453458-6 1988 The enhancement of IL-2 production due to IFN-gamma was more marked in cultures which did not include indomethacin than in cultures which contained indomethacin (1 x 10(-6) M). Indomethacin 148-160 interferon gamma Homo sapiens 42-51 3125740-3 1988 Results demonstrate that IFN-gamma release by elicited PL is lower in some CAPD patients with high peritonitis incidence (HPI) than in healthy donors or in CAPD patients with low peritonitis incidence (LPI). pl 55-57 interferon gamma Homo sapiens 25-34 3125740-5 1988 These results show that the IFN-gamma treatment in vitro could strengthen PM luminal diameter phagocytosis, oxygen metabolite generation, and bacterial killing in CAPD patients with HPI, and suggest that IFN-gamma may be considered a possible therapy in vivo for these patients. Oxygen 108-114 interferon gamma Homo sapiens 28-37 2832313-3 1988 The IFN-gamma treatment prevented replication of SFV, as determined by incorporation of [3H]uridine into SFV-RNA, and reduced expression of SFV antigens on the cell surface, as determined by lysis with antibody and complement or indirect immunofluorescence. [3h]uridine 88-99 interferon gamma Homo sapiens 4-13 2832315-0 1988 Interferon-gamma activates human neutrophil oxygen metabolism and exocytosis. Oxygen 44-50 interferon gamma Homo sapiens 0-16 3126497-7 1988 Fluorescein-conjugated murine monoclonal antibodies were used to label class I MHC proteins on interferon-gamma-treated HEC and human dermal fibroblasts. Fluorescein 0-11 interferon gamma Homo sapiens 95-111 3126497-11 1988 In contrast, both class I MHC proteins and fluorescein-labeled phosphatidylethanolamine diffused isotropically on interferon-gamma-treated HEC. phosphatidylethanolamine 63-87 interferon gamma Homo sapiens 114-130 3126497-11 1988 In contrast, both class I MHC proteins and fluorescein-labeled phosphatidylethanolamine diffused isotropically on interferon-gamma-treated HEC. Fluorescein 43-54 interferon gamma Homo sapiens 114-130 2831894-1 1988 Plasmids expressing 2 forms of human immune interferon (IFN-gamma) in E. coli have been constructed: 1) pIFNTacI which expresses IFN-gamma with an N-terminal amino acid sequence of met-cys-tyr-cys-gln-, and 2) pIFNTacII which is a derivative of pIFNTacI from which the 9 base pairs (bp) coding for the cys-tyr-cys have been deleted. met-cys-tyr-cys 181-196 interferon gamma Homo sapiens 37-65 2831894-1 1988 Plasmids expressing 2 forms of human immune interferon (IFN-gamma) in E. coli have been constructed: 1) pIFNTacI which expresses IFN-gamma with an N-terminal amino acid sequence of met-cys-tyr-cys-gln-, and 2) pIFNTacII which is a derivative of pIFNTacI from which the 9 base pairs (bp) coding for the cys-tyr-cys have been deleted. Glutamine 197-200 interferon gamma Homo sapiens 37-65 2831894-1 1988 Plasmids expressing 2 forms of human immune interferon (IFN-gamma) in E. coli have been constructed: 1) pIFNTacI which expresses IFN-gamma with an N-terminal amino acid sequence of met-cys-tyr-cys-gln-, and 2) pIFNTacII which is a derivative of pIFNTacI from which the 9 base pairs (bp) coding for the cys-tyr-cys have been deleted. Cysteine 185-188 interferon gamma Homo sapiens 37-65 2831894-1 1988 Plasmids expressing 2 forms of human immune interferon (IFN-gamma) in E. coli have been constructed: 1) pIFNTacI which expresses IFN-gamma with an N-terminal amino acid sequence of met-cys-tyr-cys-gln-, and 2) pIFNTacII which is a derivative of pIFNTacI from which the 9 base pairs (bp) coding for the cys-tyr-cys have been deleted. Tyr-Cys 189-196 interferon gamma Homo sapiens 37-65 3128273-1 1988 Recombinant-derived human interleukin 1 (IL1) alpha and beta and interferon gamma (IFN-gamma) each produced similar increases in rheumatoid synovial cell (RSC) glycolysis, as judged by increased values for glucose uptake, lactate production and cellular fructose 2,6-bisphosphate [Fru(2,6)P2]. Glucose 206-213 interferon gamma Homo sapiens 65-92 2449502-9 1988 The concentration of free intracellular Ca2+ ions is also affected by IFN-alpha and IFN-gamma activation, as monitored by the fluorescent probe, Quin 2. Quin2 145-151 interferon gamma Homo sapiens 84-93 3128273-1 1988 Recombinant-derived human interleukin 1 (IL1) alpha and beta and interferon gamma (IFN-gamma) each produced similar increases in rheumatoid synovial cell (RSC) glycolysis, as judged by increased values for glucose uptake, lactate production and cellular fructose 2,6-bisphosphate [Fru(2,6)P2]. Lactic Acid 222-229 interferon gamma Homo sapiens 65-92 3128273-1 1988 Recombinant-derived human interleukin 1 (IL1) alpha and beta and interferon gamma (IFN-gamma) each produced similar increases in rheumatoid synovial cell (RSC) glycolysis, as judged by increased values for glucose uptake, lactate production and cellular fructose 2,6-bisphosphate [Fru(2,6)P2]. fructose 2,6-diphosphate 254-279 interferon gamma Homo sapiens 65-92 3123485-8 1988 Interferon-gamma inhibited the growth of the 7 cell lines observed with the enzyme induction, and this growth inhibition was accompanied with a complete deletion of tryptophan (less than 1 microM) in the culture medium by the induction of the enzyme. Tryptophan 165-175 interferon gamma Homo sapiens 0-16 3123485-10 1988 These findings indicated that the growth inhibition by interferon-gamma was in part explained by the tryptophan depletion in the medium caused by the enzyme induction. Tryptophan 101-111 interferon gamma Homo sapiens 55-71 2452128-1 1988 Interferon-gamma (IFN-gamma) has been shown to be a potent inducer of neopterin secretion by human peripheral blood monocytes/macrophages (1). Neopterin 70-79 interferon gamma Homo sapiens 0-16 2827831-1 1988 A diminished gamma-interferon (IFN-gamma) production by T cells from patients with rheumatoid arthritis (RA) in response to autologous stimulation coincides with a defective regulation of Epstein-Barr virus (EBV) transformation and is in part due to monocyte-produced interleukin-1 (IL-1) inhibitor and prostaglandins. Prostaglandins 303-317 interferon gamma Homo sapiens 31-40 3121176-6 1988 The induction of HLA antigen expression by IFN-alpha and IFN-gamma, an effect which could increase recognition of the tumor cells by the immune system, was as great or greater in the presence of Dex as in its absence. Dexamethasone 195-198 interferon gamma Homo sapiens 57-66 3127526-4 1988 When lymphocyte preparations were costimulated with PMA, the TSST-1 effect was strongly potentiated and the levels of cytotoxic factors, IFN-gamma, and IL-2 present in supernatant fluids were comparable to those observed after treatment with PMA and PHA. Tetradecanoylphorbol Acetate 52-55 interferon gamma Homo sapiens 137-146 2452128-1 1988 Interferon-gamma (IFN-gamma) has been shown to be a potent inducer of neopterin secretion by human peripheral blood monocytes/macrophages (1). Neopterin 70-79 interferon gamma Homo sapiens 18-27 2452128-7 1988 Amongst the supernatants from PBMNC, only those which were obtained from cells activated with IFN-gamma or -alpha stimulated monocytes/macrophages to produce neopterin. Neopterin 158-167 interferon gamma Homo sapiens 94-103 2452128-10 1988 These results demonstrate that both interferons, IFN-gamma and IFN-alpha, the latter only at a 400-fold higher concentration, can trigger monocytes/macrophages directly to secrete neopterin. Neopterin 180-189 interferon gamma Homo sapiens 49-58 3129369-0 1988 Effect of 1,25-dihydroxyvitamin D3 on interferon gamma production in vitro. Calcitriol 10-34 interferon gamma Homo sapiens 38-54 3124115-5 1988 Supplementing the growth medium with additional L-tryptophan reversed the antiproliferative effect of IFN-gamma against KB cells in a dose- and time-dependent manner. Tryptophan 48-60 interferon gamma Homo sapiens 102-111 3129369-2 1988 Because lymphokines are central in the regulation and modulation of immune or inflammatory responses and since the calcium translocation is involved in the mitogen-induced activation of lymphocytes, we thought it interesting to study the role of calcitriol on interferon gamma (IFN-gamma) production in vitro. Calcitriol 246-256 interferon gamma Homo sapiens 260-287 3129369-3 1988 In this study, we report that calcitriol inhibits the IFN-gamma production by staphylococcal enterotoxin A-stimulated peripheral blood mononuclear cells (PBMC) in a dose-dependent fashion. Calcitriol 30-40 interferon gamma Homo sapiens 54-63 3124115-7 1988 The data show that the antiproliferative effect of IFN-gamma through induction of indoleamine 2,3-dioxygenase, with a consequent L-tryptophan deprivation, is an effective means of regulating cell growth. Tryptophan 129-141 interferon gamma Homo sapiens 51-60 3121172-2 1988 The mechanisms involved in this antiproliferative activity are poorly understood, but it is known that IFN-gamma can induce indoleamine 2,3-dioxygenase, which enhances tryptophan metabolism and thus depletes the cellular pool of this amino acid. Tryptophan 168-178 interferon gamma Homo sapiens 103-112 3122755-5 1988 When IL1 was added together with human recombinant interferon-gamma (IFN-gamma), the resulting Fru-2,6-P2 level was synergistically increased, whilst the combination of IFN-gamma and TPA produced only an additive increase. Tetradecanoylphorbol Acetate 183-186 interferon gamma Homo sapiens 51-67 3122755-5 1988 When IL1 was added together with human recombinant interferon-gamma (IFN-gamma), the resulting Fru-2,6-P2 level was synergistically increased, whilst the combination of IFN-gamma and TPA produced only an additive increase. Tetradecanoylphorbol Acetate 183-186 interferon gamma Homo sapiens 69-78 3121611-5 1988 (iii) Cycloheximide (50 micrograms/ml) and anisomycin (10 micron or higher) inhibited the induction by IFN-gamma but not by IFN-alpha 2, suggesting the requirement for some newly synthesized, presumably IFN-gamma-induced, protein factor(s) in IFN-gamma-mediated but not in IFN-alpha 2-mediated induction. Cycloheximide 6-19 interferon gamma Homo sapiens 103-112 3135118-0 1988 Synergism of synthetic acyltripeptide and its analogs with recombinant interferon gamma for activation of antitumor properties of human blood monocytes. acyltripeptide 23-37 interferon gamma Homo sapiens 71-87 3135118-4 1988 In a parallel experiment, a combination of a subthreshold concentration of FK-565 or its analogs (FR-42148 and FR-42149) and recombinant interferon gamma (rIFN-gamma) induced significant monocyte-mediated tumorcell killing, indicating that the effects of rIFN-gamma and acyltripeptide or its analogs in monocyte activation are synergistic. acyltripeptide 270-284 interferon gamma Homo sapiens 137-165 3141055-2 1988 Neopterin is produced by human macrophages upon stimulation with interferon gamma and is therefore a measure for activated T cells. Neopterin 0-9 interferon gamma Homo sapiens 65-81 2964957-3 1988 Dexamethasone not only suppressed by 50% the spontaneous Fc epsilon R expression on U937 cells but also completely inhibited the enhancement of their Fc epsilon R expression on U937 cells induced by PMA, IFN-gamma or H107. Dexamethasone 0-13 interferon gamma Homo sapiens 204-213 2448341-13 1988 These studies demonstrate that IFN-gamma, TNF, and LT are important stimulators of fibroblast GAG biosynthesis, that interactions between these cytokines may be important in this regulatory process, that these cytokines predominantly stimulate hyaluronic acid production and that this effect may be mediated by stimulation of fibroblast hyaluronate synthetase activity. Glycosaminoglycans 94-97 interferon gamma Homo sapiens 31-40 2448341-13 1988 These studies demonstrate that IFN-gamma, TNF, and LT are important stimulators of fibroblast GAG biosynthesis, that interactions between these cytokines may be important in this regulatory process, that these cytokines predominantly stimulate hyaluronic acid production and that this effect may be mediated by stimulation of fibroblast hyaluronate synthetase activity. Hyaluronic Acid 244-259 interferon gamma Homo sapiens 31-40 2454889-1 1988 Interferon (IFN)-alpha and -beta are produced by virus-infected cells; IFN-gamma is produced as a primary response of T lymphocytes to mitogenic stimulation, IFN-gamma gene activation being brought about by changes in Ca2+ and phosphatidyl inositol metabolism. Phosphatidylinositols 227-248 interferon gamma Homo sapiens 71-80 2454889-1 1988 Interferon (IFN)-alpha and -beta are produced by virus-infected cells; IFN-gamma is produced as a primary response of T lymphocytes to mitogenic stimulation, IFN-gamma gene activation being brought about by changes in Ca2+ and phosphatidyl inositol metabolism. Phosphatidylinositols 227-248 interferon gamma Homo sapiens 158-167 2854542-2 1988 IFN-y augments the H2O2 secretion of human monocytes which indirectly can be measured by chemiluminescence. Hydrogen Peroxide 19-23 interferon gamma Homo sapiens 0-5 2845200-2 1988 PGE2, a potent inducer of intracellular cyclic AMP (cAMP) in HL-60 cells, augmented monocyte-associated cell surface antigens induced by human gamma-interferon (IFN-gamma) or 1 alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) in these cells. Dinoprostone 0-4 interferon gamma Homo sapiens 161-182 2845200-2 1988 PGE2, a potent inducer of intracellular cyclic AMP (cAMP) in HL-60 cells, augmented monocyte-associated cell surface antigens induced by human gamma-interferon (IFN-gamma) or 1 alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) in these cells. Cyclic AMP 52-56 interferon gamma Homo sapiens 161-182 2845200-5 1988 PGE2 also enhanced the reduction of c-myc expression and the down-regulation of transferrin receptor by IFN-gamma or 1,25(OH)2D3, whereas PGE2 alone did not induce these phenotypic changes. Dinoprostone 0-4 interferon gamma Homo sapiens 104-113 3121611-5 1988 (iii) Cycloheximide (50 micrograms/ml) and anisomycin (10 micron or higher) inhibited the induction by IFN-gamma but not by IFN-alpha 2, suggesting the requirement for some newly synthesized, presumably IFN-gamma-induced, protein factor(s) in IFN-gamma-mediated but not in IFN-alpha 2-mediated induction. Cycloheximide 6-19 interferon gamma Homo sapiens 203-212 3131593-0 1988 Effect of interferon-gamma on HLA class II antigen expression and sensitivity to prostaglandin E1 by normal and leukemic myeloid progenitors. Alprostadil 81-97 interferon gamma Homo sapiens 10-26 3131593-3 1988 Since interferon gamma (IFN-gamma) is a potent inducer of the expression of HLA class II (DR and to a lesser extent DQ) antigens, we have sought to determine the extent to which this agent can modulate both the antigenic pattern of normal and leukemic progenitors and their sensitivity to PGE 1. Alprostadil 289-294 interferon gamma Homo sapiens 6-33 3121611-5 1988 (iii) Cycloheximide (50 micrograms/ml) and anisomycin (10 micron or higher) inhibited the induction by IFN-gamma but not by IFN-alpha 2, suggesting the requirement for some newly synthesized, presumably IFN-gamma-induced, protein factor(s) in IFN-gamma-mediated but not in IFN-alpha 2-mediated induction. Cycloheximide 6-19 interferon gamma Homo sapiens 203-212 3131593-5 1988 Pre-incubation for 72 h with and without IFN-gamma produces the following changes in PGE 1 sensitivity: (1) normal CFU-GM lose some sensitivity to PGE 1. Prostaglandins E 85-88 interferon gamma Homo sapiens 41-50 3121611-5 1988 (iii) Cycloheximide (50 micrograms/ml) and anisomycin (10 micron or higher) inhibited the induction by IFN-gamma but not by IFN-alpha 2, suggesting the requirement for some newly synthesized, presumably IFN-gamma-induced, protein factor(s) in IFN-gamma-mediated but not in IFN-alpha 2-mediated induction. Anisomycin 43-53 interferon gamma Homo sapiens 103-112 3131593-5 1988 Pre-incubation for 72 h with and without IFN-gamma produces the following changes in PGE 1 sensitivity: (1) normal CFU-GM lose some sensitivity to PGE 1. Prostaglandins E 147-150 interferon gamma Homo sapiens 41-50 3131593-7 1988 (2) CML CFU-GM, preincubated with IFN-gamma regain a significant sensitivity to high concentrations of PGE 1. Alprostadil 103-108 interferon gamma Homo sapiens 34-43 3121611-5 1988 (iii) Cycloheximide (50 micrograms/ml) and anisomycin (10 micron or higher) inhibited the induction by IFN-gamma but not by IFN-alpha 2, suggesting the requirement for some newly synthesized, presumably IFN-gamma-induced, protein factor(s) in IFN-gamma-mediated but not in IFN-alpha 2-mediated induction. Anisomycin 43-53 interferon gamma Homo sapiens 203-212 3131593-9 1988 They also show that, although incubation with IFN-gamma for 72 h in a liquid culture system does not significantly affect the expression of HLA class II molecules by progenitor cells, it may increase their sensitivity to PGE, particularly in the case of CML CFU-GM. Prostaglandins E 221-224 interferon gamma Homo sapiens 46-55 3121611-5 1988 (iii) Cycloheximide (50 micrograms/ml) and anisomycin (10 micron or higher) inhibited the induction by IFN-gamma but not by IFN-alpha 2, suggesting the requirement for some newly synthesized, presumably IFN-gamma-induced, protein factor(s) in IFN-gamma-mediated but not in IFN-alpha 2-mediated induction. Anisomycin 43-53 interferon gamma Homo sapiens 203-212 3121611-6 1988 Interestingly, this inhibition by cycloheximide of the IFN-gamma-mediated induction was overcome by 24 h, whereas a sustained inhibition was obtained with anisomycin. Cycloheximide 34-47 interferon gamma Homo sapiens 55-64 3121611-8 1988 As analyzed by nuclear runoff transcription, IFN-gamma induced the transcription of C5-4-specific RNA within 2 h and it was inhibited by cycloheximide, indicating that the newly synthesized protein mediator(s) required plays a role in the transcriptional activation of the C5-4 gene by IFN-gamma. Cycloheximide 137-150 interferon gamma Homo sapiens 45-54 3121611-8 1988 As analyzed by nuclear runoff transcription, IFN-gamma induced the transcription of C5-4-specific RNA within 2 h and it was inhibited by cycloheximide, indicating that the newly synthesized protein mediator(s) required plays a role in the transcriptional activation of the C5-4 gene by IFN-gamma. Cycloheximide 137-150 interferon gamma Homo sapiens 286-295 3122387-2 1988 Several studies have shown a decrease in interleukin 2 (IL-2) and interferon-Gamma (IFN-G) production of renal Tx recipients on CsA treatment and have suggested that increases in lymphokine production can be correlated with rejection episodes. Cyclosporine 128-131 interferon gamma Homo sapiens 66-82 3124262-6 1988 The deficient IFN-gamma production was compensated in RA by co-stimulation of PHA or OKT3 with phorbol myristic acetate (PMA). phorbol myristic acetate 95-119 interferon gamma Homo sapiens 14-23 3124262-6 1988 The deficient IFN-gamma production was compensated in RA by co-stimulation of PHA or OKT3 with phorbol myristic acetate (PMA). Tetradecanoylphorbol Acetate 121-124 interferon gamma Homo sapiens 14-23 3124262-7 1988 In addition, the combination of the calcium ionophore A 23187 and PMA induced a strong IFN-gamma secretion in all patient groups and in the controls. Calcium 36-43 interferon gamma Homo sapiens 87-96 2460727-0 1988 Systemic interferon-gamma therapy for cutaneous melanoma: subversive role of keratinocyte prostaglandin E production induced by interferon-gamma. Prostaglandins E 90-105 interferon gamma Homo sapiens 128-144 3122387-2 1988 Several studies have shown a decrease in interleukin 2 (IL-2) and interferon-Gamma (IFN-G) production of renal Tx recipients on CsA treatment and have suggested that increases in lymphokine production can be correlated with rejection episodes. Cyclosporine 128-131 interferon gamma Homo sapiens 84-89 2826339-1 1987 The combination of retinoic acid or tumor necrosis factor alpha (TNF-alpha) with interferon gamma (IFN-gamma) resulted in a synergistic amplification of the anti-proliferative effect of IFN-gamma on cultured breast cancer cells. Tretinoin 19-32 interferon gamma Homo sapiens 81-108 2826339-1 1987 The combination of retinoic acid or tumor necrosis factor alpha (TNF-alpha) with interferon gamma (IFN-gamma) resulted in a synergistic amplification of the anti-proliferative effect of IFN-gamma on cultured breast cancer cells. Tretinoin 19-32 interferon gamma Homo sapiens 99-108 2826339-5 1987 On the other hand, only TNF-alpha and not retinoic acid was able to increase the IFN-gamma induced expression of HLA-DR on the cell surface. Tretinoin 42-55 interferon gamma Homo sapiens 81-90 2826339-7 1987 The combinations of retinoic acid with IFN-gamma increased the down-regulation of specific binding sites for 125I-IFN-gamma. Tretinoin 20-33 interferon gamma Homo sapiens 39-48 2826339-7 1987 The combinations of retinoic acid with IFN-gamma increased the down-regulation of specific binding sites for 125I-IFN-gamma. Tretinoin 20-33 interferon gamma Homo sapiens 114-123 2826339-9 1987 Data obtained in this study demonstrate a different pattern of action between retinoic acid and TNF-alpha regarding their synergism in combination with IFN-gamma. Tretinoin 78-91 interferon gamma Homo sapiens 152-161 2835054-2 1987 IFN-gamma influences the activity of macrophages, granulocytes, B-lymphocytes, suppressor-T-lymphocytes and natural killer cells as well as the production of prostaglandins and leukotrienes, bone resorption, collagen synthesis and expression of HLA class II antigens. Prostaglandins 158-172 interferon gamma Homo sapiens 0-9 2835054-2 1987 IFN-gamma influences the activity of macrophages, granulocytes, B-lymphocytes, suppressor-T-lymphocytes and natural killer cells as well as the production of prostaglandins and leukotrienes, bone resorption, collagen synthesis and expression of HLA class II antigens. Leukotrienes 177-189 interferon gamma Homo sapiens 0-9 3119653-2 1987 The sarcoid cells, all collected from patients with normal calcium metabolism, synthesized 1,25-(OH)2-[3H]D3 from the substrate 25-hydroxyvitamin [3H]D3 (25OH-[3H]D3), whereas in vitro incubation with recombinant human interferon-gamma (IFN gamma) or lipopolysaccharide (LPS) was required for induction of synthesis of the hormone by normal PAM. Cholecalciferol 106-108 interferon gamma Homo sapiens 219-235 3129362-0 1987 Interferon-gamma for the treatment of metastatic renal cancer: dose-dependent stimulation and downregulation of beta-2 microglobulin and neopterin responses. Neopterin 137-146 interferon gamma Homo sapiens 0-16 2960673-5 1987 Dissociation of bound 125I IFN beta ser from Daudi cells was slow (t1/2 = 1.2 h) of bound radiolabeled ligand was observed in the presence of unlabeled IFN beta ser, naturally produced IFN beta, and IFN alpha 6, but was not observed with unlabeled IFN gamma or nonspecific proteins. Serine 36-39 interferon gamma Homo sapiens 248-257 3118958-1 1987 The fluorescence intensity of a unique tryptophan 36 in human interferon-gamma was drastically decreased below pH 4 with a concomitant decrease of antiviral activity. Tryptophan 39-49 interferon gamma Homo sapiens 62-78 3124810-0 1987 Induction of synthesis of components of the hydrogen peroxide-generating oxidase during activation of the human monocytic cell line U937 by interferon-gamma. Hydrogen Peroxide 44-61 interferon gamma Homo sapiens 140-156 3124810-1 1987 Increased amounts of cytochrome b-245 and a 45 kDa polypeptide component of the hydrogen peroxide-generating oxidase were detected in the human monocytic cell line U937 after incubation in interferon-gamma. Hydrogen Peroxide 80-97 interferon gamma Homo sapiens 189-205 3119591-5 1987 As measured by immunoprecipitation of [35S]methionine pulse-labeled extracts or by immunoblot analysis of unlabeled extracts, the synthesis of p54 was greatly elevated in three human cell lines treated with IFN-gamma, amnion U, fibroblast GM2767, and fibroblast F153. Sulfur-35 39-42 interferon gamma Homo sapiens 207-216 3119591-5 1987 As measured by immunoprecipitation of [35S]methionine pulse-labeled extracts or by immunoblot analysis of unlabeled extracts, the synthesis of p54 was greatly elevated in three human cell lines treated with IFN-gamma, amnion U, fibroblast GM2767, and fibroblast F153. Methionine 43-53 interferon gamma Homo sapiens 207-216 3117136-6 1987 Enhanced phorbol myristate acetate-stimulated phosphorylation of a 48-kd substrate was observed in 32P-labeled intact cells treated with 1,25(OH)2D3 alone or in combination with IFN-gamma. Tetradecanoylphorbol Acetate 9-34 interferon gamma Homo sapiens 178-187 3117136-6 1987 Enhanced phorbol myristate acetate-stimulated phosphorylation of a 48-kd substrate was observed in 32P-labeled intact cells treated with 1,25(OH)2D3 alone or in combination with IFN-gamma. Phosphorus-32 99-102 interferon gamma Homo sapiens 178-187 3119253-1 1987 This is a method for the simultaneous determination of neopterin, a product of interferon-gamma-activated macrophages, and creatinine in serum. Neopterin 55-64 interferon gamma Homo sapiens 79-95 3123367-3 1987 In our experiments, we investigated the influence of bryostatin 1 on the synthesis of interleukin 2 (IL2) and interferon-gamma (IFN-gamma) by ionophore A23187 or mitogen-induced human blood lymphocytes. bryostatin 1 53-65 interferon gamma Homo sapiens 110-126 3123367-3 1987 In our experiments, we investigated the influence of bryostatin 1 on the synthesis of interleukin 2 (IL2) and interferon-gamma (IFN-gamma) by ionophore A23187 or mitogen-induced human blood lymphocytes. bryostatin 1 53-65 interferon gamma Homo sapiens 128-137 3123367-3 1987 In our experiments, we investigated the influence of bryostatin 1 on the synthesis of interleukin 2 (IL2) and interferon-gamma (IFN-gamma) by ionophore A23187 or mitogen-induced human blood lymphocytes. Calcimycin 152-158 interferon gamma Homo sapiens 110-126 3123367-3 1987 In our experiments, we investigated the influence of bryostatin 1 on the synthesis of interleukin 2 (IL2) and interferon-gamma (IFN-gamma) by ionophore A23187 or mitogen-induced human blood lymphocytes. Calcimycin 152-158 interferon gamma Homo sapiens 128-137 3119653-2 1987 The sarcoid cells, all collected from patients with normal calcium metabolism, synthesized 1,25-(OH)2-[3H]D3 from the substrate 25-hydroxyvitamin [3H]D3 (25OH-[3H]D3), whereas in vitro incubation with recombinant human interferon-gamma (IFN gamma) or lipopolysaccharide (LPS) was required for induction of synthesis of the hormone by normal PAM. Cholecalciferol 106-108 interferon gamma Homo sapiens 237-246 3119653-7 1987 1,25-(OH)2D3 production by sarcoid PAM was enhanced by lipopolysaccharide and IFN gamma. Calcitriol 0-12 interferon gamma Homo sapiens 78-87 3121562-0 1987 In vitro growth inhibition of cisplatin-resistant human lung cancer cell lines by recombinant human tumor necrosis factor and/or recombinant human interferon-gamma by virtue of collateral sensitivity. Cisplatin 30-39 interferon gamma Homo sapiens 147-163 3119653-8 1987 Likewise, recombinant human interleukin-2 stimulated 1,25-(OH)2D3 production by sarcoid PAM, suggesting a possible role for both IFN gamma and interleukin-2 in the induction of 1,25-(OH)2D3 synthesis by sarcoid PAM in vivo. Calcitriol 177-189 interferon gamma Homo sapiens 129-138 3122784-0 1987 Interferon-gamma-induced degradation of tryptophan by human cells in vitro. Tryptophan 40-50 interferon gamma Homo sapiens 0-16 3116090-11 1987 A similar synergism with C5a/C5a des Arg was seen with interferon-gamma. Arginine 37-40 interferon gamma Homo sapiens 55-71 3115598-0 1987 Histamine acts directly on human T cells to inhibit interleukin-2 and interferon-gamma production. Histamine 0-9 interferon gamma Homo sapiens 70-86 3115598-2 1987 Histamine inhibits the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) by purified human peripheral T cells activated in the presence of either intact monocytes or metabolically inactive fixed Raji and U698 cells as accessory cells. Histamine 0-9 interferon gamma Homo sapiens 62-78 3115598-2 1987 Histamine inhibits the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) by purified human peripheral T cells activated in the presence of either intact monocytes or metabolically inactive fixed Raji and U698 cells as accessory cells. Histamine 0-9 interferon gamma Homo sapiens 80-89 3115598-4 1987 However, activation by the phorbol ester PMA in conjunction with either PHA or the calcium ionophore A23187 induces large amounts of IFN-gamma and IL-2. Phorbol Esters 27-40 interferon gamma Homo sapiens 133-142 3115598-4 1987 However, activation by the phorbol ester PMA in conjunction with either PHA or the calcium ionophore A23187 induces large amounts of IFN-gamma and IL-2. Calcium 83-90 interferon gamma Homo sapiens 133-142 3115598-4 1987 However, activation by the phorbol ester PMA in conjunction with either PHA or the calcium ionophore A23187 induces large amounts of IFN-gamma and IL-2. Calcimycin 101-107 interferon gamma Homo sapiens 133-142 2821069-0 1987 Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease. Superoxides 48-58 interferon gamma Homo sapiens 12-28 2821069-2 1987 Granulocytes and macrophages from three patients in two kindreds with "variant" X-linked CGD (i.e., with very low, but detectable, baseline superoxide-generating activity) responded to IFN-gamma with enhanced nitroblue tetrazolium reduction and two- to eightfold increases in superoxide generation. Superoxides 140-150 interferon gamma Homo sapiens 185-194 2821069-2 1987 Granulocytes and macrophages from three patients in two kindreds with "variant" X-linked CGD (i.e., with very low, but detectable, baseline superoxide-generating activity) responded to IFN-gamma with enhanced nitroblue tetrazolium reduction and two- to eightfold increases in superoxide generation. Tetrazolium Salts 219-230 interferon gamma Homo sapiens 185-194 2821069-2 1987 Granulocytes and macrophages from three patients in two kindreds with "variant" X-linked CGD (i.e., with very low, but detectable, baseline superoxide-generating activity) responded to IFN-gamma with enhanced nitroblue tetrazolium reduction and two- to eightfold increases in superoxide generation. Superoxides 276-286 interferon gamma Homo sapiens 185-194 3118749-4 1987 Interferon gamma production was reduced to less than 2% of control value in the presence of histamine. Histamine 92-101 interferon gamma Homo sapiens 0-16 3116897-0 1987 Fusion and activation of human alveolar macrophages induced by recombinant interferon-gamma and their suppression by dexamethasone. Dexamethasone 117-130 interferon gamma Homo sapiens 75-91 3116897-7 1987 Adding IFN-gamma also activated some functions of the alveolar macrophages, as measured by increased glucose consumption and cytostatic activity against HeLa cells. Glucose 101-108 interferon gamma Homo sapiens 7-16 3116897-9 1987 The glucose consumption of alveolar macrophages from patients with cancer was relatively low, but IFN-gamma restored their glucose consumption approximately to the level in a healthy volunteer and in patients with pneumonia. Glucose 123-130 interferon gamma Homo sapiens 98-107 3116897-10 1987 Dexamethasone inhibited both the fusion and the activation of alveolar macrophages induced by IFN-gamma. Dexamethasone 0-13 interferon gamma Homo sapiens 94-103 3117353-2 1987 Layered cells were detached after a 3-day treatment with interferon either by trypsin-EDTA, trypsin, protease or cooling to 4 degrees C. Treatment with interferon-gamma (500 unit/ml) significantly increased the incubation time for trypsin-EDTA, EDTA and at 4 degrees C necessary to bring cells into suspension for the 4 cell lines BT-20, ZR-75.1, MCF-7 and HEP-2. Edetic Acid 86-90 interferon gamma Homo sapiens 152-168 3117353-2 1987 Layered cells were detached after a 3-day treatment with interferon either by trypsin-EDTA, trypsin, protease or cooling to 4 degrees C. Treatment with interferon-gamma (500 unit/ml) significantly increased the incubation time for trypsin-EDTA, EDTA and at 4 degrees C necessary to bring cells into suspension for the 4 cell lines BT-20, ZR-75.1, MCF-7 and HEP-2. Edetic Acid 239-243 interferon gamma Homo sapiens 152-168 3117353-2 1987 Layered cells were detached after a 3-day treatment with interferon either by trypsin-EDTA, trypsin, protease or cooling to 4 degrees C. Treatment with interferon-gamma (500 unit/ml) significantly increased the incubation time for trypsin-EDTA, EDTA and at 4 degrees C necessary to bring cells into suspension for the 4 cell lines BT-20, ZR-75.1, MCF-7 and HEP-2. Edetic Acid 239-243 interferon gamma Homo sapiens 152-168 3113788-0 1987 Induction of interferon-gamma in human leukocyte cultures stimulated by Zn2+. Zinc 72-76 interferon gamma Homo sapiens 13-29 3113788-5 1987 The type of interferon induced by Zn2+ was interferon-gamma, as proven by the use of specific antisera. Zinc 34-38 interferon gamma Homo sapiens 43-59 2443564-1 1987 Degradation of tryptophan to kynurenine, catalyzed by indoleamine 2,3-dioxygenase (IDO), has been augmented in human epithelial cell lines treated with human interferon-gamma (HuIFN-gamma). Tryptophan 15-25 interferon gamma Homo sapiens 158-174 2443564-1 1987 Degradation of tryptophan to kynurenine, catalyzed by indoleamine 2,3-dioxygenase (IDO), has been augmented in human epithelial cell lines treated with human interferon-gamma (HuIFN-gamma). Kynurenine 29-39 interferon gamma Homo sapiens 158-174 3113513-6 1987 Preincubation of B-PLL cells with IFN-gamma induces responsiveness to PMA, whereas IFN-gamma alone had no effect on these cells when pretreated with PMA. Tetradecanoylphorbol Acetate 70-73 interferon gamma Homo sapiens 34-43 3122784-1 1987 Several human cells were investigated for their ability to degrade tryptophan and to synthesize neopterin upon induction by interferon-gamma (500 units/ml for 48 h). Neopterin 96-105 interferon gamma Homo sapiens 124-140 3122784-3 1987 Fibroblasts, A-22 arachnoidea, HK-2351 scalp, T-2346 meningeom and HeLa cervical carcinoma cells but not HL-60 promyelocytic leukaemia cells were found to degrade tryptophan upon induction by interferon-gamma. Tryptophan 163-173 interferon gamma Homo sapiens 192-208 3122784-7 1987 Human macrophages form 3-hydroxyanthranilic acid and neopterin, but not 3-hydroxykynurenine, beside kynurenine and anthranilic acid upon activation by interferon-gamma. 3-Hydroxyanthranilic Acid 23-48 interferon gamma Homo sapiens 151-167 3122784-7 1987 Human macrophages form 3-hydroxyanthranilic acid and neopterin, but not 3-hydroxykynurenine, beside kynurenine and anthranilic acid upon activation by interferon-gamma. Neopterin 53-62 interferon gamma Homo sapiens 151-167 3122784-7 1987 Human macrophages form 3-hydroxyanthranilic acid and neopterin, but not 3-hydroxykynurenine, beside kynurenine and anthranilic acid upon activation by interferon-gamma. anthranilic acid 32-48 interferon gamma Homo sapiens 151-167 3122784-8 1987 These data indicate that several human cells can be induced by interferon-gamma to degrade tryptophan. Tryptophan 91-101 interferon gamma Homo sapiens 63-79 3122784-9 1987 The interferon-gamma induced synthesis of 3-hydroxyanthranilic acid and neopterin, however, appears to be restricted to human macrophages. 3-Hydroxyanthranilic Acid 42-67 interferon gamma Homo sapiens 4-20 3122784-9 1987 The interferon-gamma induced synthesis of 3-hydroxyanthranilic acid and neopterin, however, appears to be restricted to human macrophages. Neopterin 72-81 interferon gamma Homo sapiens 4-20 3323193-1 1987 A synthetic gene for human pancreatic secretory trypsin inhibitor (PSTI) was fused to the coding sequence for the amino-terminal 135 amino acid residues of human interferon-gamma (IFN-gamma) by interposing a methionine codon sequence, and the resulting hybrid gene was efficiently expressed in Escherichia coli cells. Methionine 208-218 interferon gamma Homo sapiens 162-178 3323193-1 1987 A synthetic gene for human pancreatic secretory trypsin inhibitor (PSTI) was fused to the coding sequence for the amino-terminal 135 amino acid residues of human interferon-gamma (IFN-gamma) by interposing a methionine codon sequence, and the resulting hybrid gene was efficiently expressed in Escherichia coli cells. Methionine 208-218 interferon gamma Homo sapiens 180-189 3118946-3 1987 Addition of 0.05-0.2 M NaCl to a pH 3.5 sample increased the amount of beta-sheet structure with no change in the amount of alpha-helix and also induced reversible self-association of interferon gamma to form large aggregates from the monomer. Sodium Chloride 23-27 interferon gamma Homo sapiens 184-200 3118946-4 1987 When samples at pH 3.5 were dialyzed against 0.1 M ammonium acetate (pH 6.9) to refold interferon gamma, the samples that contained NaCl in acid formed aggregates upon dialysis while those without NaCl formed a dimer apparently identical with the starting protein (i.e., before acid treatment). Sodium Chloride 132-136 interferon gamma Homo sapiens 87-103 3118946-5 1987 Thus, the self-association of interferon gamma in acid is closely correlated with its aggregation behavior in 0.1 M ammonium acetate after removal of acid. ammonium acetate 116-132 interferon gamma Homo sapiens 30-46 3112152-2 1987 Upon exposure to recombinant human interferon-gamma (IFN-gamma) both bone marrow-derived macrophages (BMM) and pulmonary alveolar macrophages (PAM) produced a polar 25-(OH)D3 metabolite which was purified from conditioned media and unequivocally identified as 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) by UV-absorbance spectrophotometry and mass spectrometry. Calcifediol 165-174 interferon gamma Homo sapiens 35-51 3112152-2 1987 Upon exposure to recombinant human interferon-gamma (IFN-gamma) both bone marrow-derived macrophages (BMM) and pulmonary alveolar macrophages (PAM) produced a polar 25-(OH)D3 metabolite which was purified from conditioned media and unequivocally identified as 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) by UV-absorbance spectrophotometry and mass spectrometry. Calcifediol 165-174 interferon gamma Homo sapiens 53-62 3112152-2 1987 Upon exposure to recombinant human interferon-gamma (IFN-gamma) both bone marrow-derived macrophages (BMM) and pulmonary alveolar macrophages (PAM) produced a polar 25-(OH)D3 metabolite which was purified from conditioned media and unequivocally identified as 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) by UV-absorbance spectrophotometry and mass spectrometry. 1,25-dihydroxyvitamin d3 (1,25-(oh)2d3 260-298 interferon gamma Homo sapiens 35-51 3112152-2 1987 Upon exposure to recombinant human interferon-gamma (IFN-gamma) both bone marrow-derived macrophages (BMM) and pulmonary alveolar macrophages (PAM) produced a polar 25-(OH)D3 metabolite which was purified from conditioned media and unequivocally identified as 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) by UV-absorbance spectrophotometry and mass spectrometry. 1,25-dihydroxyvitamin d3 (1,25-(oh)2d3 260-298 interferon gamma Homo sapiens 53-62 3112152-6 1987 Our data suggest that locally high levels of 1,25-(OH)2D3 in the microenvironment of IFN-gamma-stimulated BMM and PAM may modulate the function of hormone-responsive cells. Calcitriol 45-57 interferon gamma Homo sapiens 85-94 3113436-0 1987 The induction of IFN-gamma production and m-RNAs of interleukin 2 and IFN-gamma by phorbol esters and a calcium ionophore. Phorbol Esters 83-97 interferon gamma Homo sapiens 17-26 3113436-0 1987 The induction of IFN-gamma production and m-RNAs of interleukin 2 and IFN-gamma by phorbol esters and a calcium ionophore. Phorbol Esters 83-97 interferon gamma Homo sapiens 70-79 3113436-0 1987 The induction of IFN-gamma production and m-RNAs of interleukin 2 and IFN-gamma by phorbol esters and a calcium ionophore. Calcium 104-111 interferon gamma Homo sapiens 17-26 3113436-0 1987 The induction of IFN-gamma production and m-RNAs of interleukin 2 and IFN-gamma by phorbol esters and a calcium ionophore. Calcium 104-111 interferon gamma Homo sapiens 70-79 3113436-1 1987 Human peripheral blood mononuclear leukocytes were found to produce large amounts of interferon-gamma in response to the calcium ionophore A23187 combined with the phorbol ester mezerein. Calcium 121-128 interferon gamma Homo sapiens 85-101 3113436-1 1987 Human peripheral blood mononuclear leukocytes were found to produce large amounts of interferon-gamma in response to the calcium ionophore A23187 combined with the phorbol ester mezerein. Calcimycin 139-145 interferon gamma Homo sapiens 85-101 3113436-1 1987 Human peripheral blood mononuclear leukocytes were found to produce large amounts of interferon-gamma in response to the calcium ionophore A23187 combined with the phorbol ester mezerein. phorbol ester mezerein 164-186 interferon gamma Homo sapiens 85-101 3113436-3 1987 A23187 plus mezerein induced high levels of interleukin-2 and interferon-gamma mRNAs. Calcimycin 0-6 interferon gamma Homo sapiens 62-78 3113436-3 1987 A23187 plus mezerein induced high levels of interleukin-2 and interferon-gamma mRNAs. mezerein 12-20 interferon gamma Homo sapiens 62-78 3110282-3 1987 CD3- Leu-11+ LGL require only a single signal for IFN-gamma production because phytohemagglutinin (PHA), phorbol myristate acetate (PMA), IL 2, or ionomycin can each independently induce IFN-gamma production. Tetradecanoylphorbol Acetate 105-130 interferon gamma Homo sapiens 50-59 3040858-10 1987 In fact, the measurement of calcium influx into HL-60 cells showed that a remarkable and time-dependent calcium accumulation was caused by IFN-gamma, and that depletion of Ca2+ from culture medium resulted in failure of IFN-gamma to induce class II antigen expression. Calcium 104-111 interferon gamma Homo sapiens 139-148 3040858-12 1987 These results suggest that IFN-gamma stimulates calcium influx and activates the calmodulin branch of the calcium messenger system, resulting in the induction of class II antigen expression on HL-60 cells. Calcium 48-55 interferon gamma Homo sapiens 27-36 3040858-12 1987 These results suggest that IFN-gamma stimulates calcium influx and activates the calmodulin branch of the calcium messenger system, resulting in the induction of class II antigen expression on HL-60 cells. Calcium 106-113 interferon gamma Homo sapiens 27-36 3040858-13 1987 On the other hand, cross-linking of FcR elicited the accumulation of intracellular cAMP, which appeared to suppress the IFN-gamma-induced calcium influx, resulting in annulling HLA class II antigen-inducing activity of IFN-gamma. Cyclic AMP 83-87 interferon gamma Homo sapiens 120-129 3040858-13 1987 On the other hand, cross-linking of FcR elicited the accumulation of intracellular cAMP, which appeared to suppress the IFN-gamma-induced calcium influx, resulting in annulling HLA class II antigen-inducing activity of IFN-gamma. Cyclic AMP 83-87 interferon gamma Homo sapiens 219-228 3040858-13 1987 On the other hand, cross-linking of FcR elicited the accumulation of intracellular cAMP, which appeared to suppress the IFN-gamma-induced calcium influx, resulting in annulling HLA class II antigen-inducing activity of IFN-gamma. Calcium 138-145 interferon gamma Homo sapiens 120-129 3040858-13 1987 On the other hand, cross-linking of FcR elicited the accumulation of intracellular cAMP, which appeared to suppress the IFN-gamma-induced calcium influx, resulting in annulling HLA class II antigen-inducing activity of IFN-gamma. Calcium 138-145 interferon gamma Homo sapiens 219-228 2439597-9 1987 The NKCC-enhancing effect of serotonin was additive to that induced by IFN-alpha, IFN-gamma, or IL 2, but not to histamine. Serotonin 29-38 interferon gamma Homo sapiens 82-91 3117907-1 1987 Previous reports have documented that cyclosporin A (CsA) can inhibit the production of interferon-gamma (HuIFN-gamma) and interleukin-2 (IL-2). Cyclosporine 53-56 interferon gamma Homo sapiens 88-104 3110282-3 1987 CD3- Leu-11+ LGL require only a single signal for IFN-gamma production because phytohemagglutinin (PHA), phorbol myristate acetate (PMA), IL 2, or ionomycin can each independently induce IFN-gamma production. Tetradecanoylphorbol Acetate 105-130 interferon gamma Homo sapiens 187-196 3110526-0 1987 Human macrophages degrade tryptophan upon induction by interferon-gamma. Tryptophan 26-36 interferon gamma Homo sapiens 55-71 3110526-3 1987 Tryptophan was decreased and the four other compounds were increased in supernatants of peripheral blood mononuclear cells activated by interferon-gamma (250 U/ml), interferon-alpha (10.000 U/ml) and phytohemagglutinin (1 microgram/ml). Tryptophan 0-10 interferon gamma Homo sapiens 136-152 3110526-4 1987 After splitting of peripheral blood mononuclear cells by adherence, the monocytes and macrophages but not the T-cells degraded tryptophan upon stimulation by interferon-gamma in a dose dependent manner. Tryptophan 127-137 interferon gamma Homo sapiens 158-174 3036943-0 1987 Identification of interferon-gamma as the lymphokine that mediates leukotriene B4-induced immunoregulation. Leukotriene B4 67-81 interferon gamma Homo sapiens 18-34 3110526-5 1987 Supernatants of phytohemagglutinin stimulated but not of resting T-cells were found to induce tryptophan degradation by macrophages, the active principle being neutralized by an antiserum for interferon-gamma. Tryptophan 94-104 interferon gamma Homo sapiens 192-208 3110526-6 1987 Thus phytohemagglutinin acts by activating T-cells to release interferon-gamma which in turn induces macrophages to degrade tryptophan. Tryptophan 124-134 interferon gamma Homo sapiens 62-78 3301338-8 1987 Stimulation of macrophages with recombinant human interferon-gamma and neutralization of the effect of T cell supernatants by addition of a monoclonal antibody specific for human interferon-gamma showed that immune interferon induced the alterations in GTP cyclohydrolase I activity and neopterin concentration. Neopterin 287-296 interferon gamma Homo sapiens 50-66 3301338-8 1987 Stimulation of macrophages with recombinant human interferon-gamma and neutralization of the effect of T cell supernatants by addition of a monoclonal antibody specific for human interferon-gamma showed that immune interferon induced the alterations in GTP cyclohydrolase I activity and neopterin concentration. Neopterin 287-296 interferon gamma Homo sapiens 179-195 2439242-6 1987 Pretreatment of monocytes with recombinant human interferon (IFN)-gamma or IFN-alpha for 18 hr resulted in enhanced release of labeled arachidonic acid and increased conversion to autocoids after TPA or ionophore stimulation. Arachidonic Acid 135-151 interferon gamma Homo sapiens 49-71 2439242-6 1987 Pretreatment of monocytes with recombinant human interferon (IFN)-gamma or IFN-alpha for 18 hr resulted in enhanced release of labeled arachidonic acid and increased conversion to autocoids after TPA or ionophore stimulation. Tetradecanoylphorbol Acetate 196-199 interferon gamma Homo sapiens 49-71 3140597-7 1987 The IFN gamma-ELISA works in phosphate buffer as well as in tissue culture medium or human serum. Phosphates 29-38 interferon gamma Homo sapiens 4-13 3105867-6 1987 In two cell lines with an induced resistance to mitomycin C, an increase in resistance to combined TNF-alpha and IFN-gamma treatment correlated with an increasing resistance to mitomycin C. Mitomycin 48-59 interferon gamma Homo sapiens 113-122 3109913-2 1987 Natural human interferon gamma(IFN-gamma) was purified from the conditioned medium of peripheral blood leukocytes using selective silica gel adsorption and antibody-affinity chromatography. Silica Gel 130-140 interferon gamma Homo sapiens 14-40 3109913-4 1987 Structural analysis of this natural IFN-gamma preparation demonstrated a pyroglutamate residue at the amino terminus and a heterogeneous carboxyl terminus. Pyrrolidonecarboxylic Acid 73-86 interferon gamma Homo sapiens 36-45 2954953-3 1987 Triton X-100 extracts obtained from either intact cells or membrane preparations were passed through an immobilized interferon-gamma column. Octoxynol 0-12 interferon gamma Homo sapiens 116-132 3035934-4 1987 The hormone 1 alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] that protects monocytes from thermal injury had similar effects on the HS response in U937 cells, increasing synthesis of HSPs and levels of HSP 70 mRNA and partially preventing the decrease in normal protein synthesis, whereas interferon-gamma had no effect. Calcitriol 12-42 interferon gamma Homo sapiens 286-302 3035934-4 1987 The hormone 1 alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] that protects monocytes from thermal injury had similar effects on the HS response in U937 cells, increasing synthesis of HSPs and levels of HSP 70 mRNA and partially preventing the decrease in normal protein synthesis, whereas interferon-gamma had no effect. Calcitriol 44-56 interferon gamma Homo sapiens 286-302 3040807-2 1987 We tested the hypothesis that morphine and the endogenous opioid beta-endorphin (beta-END), a pituitary peptide released in increased concentrations during stress, can suppress the production of the key macrophage-activating lymphokine interferon-gamma (IFN-gamma) by cultured human peripheral blood mononuclear cells (PBMNC). Morphine 30-38 interferon gamma Homo sapiens 236-252 3040807-2 1987 We tested the hypothesis that morphine and the endogenous opioid beta-endorphin (beta-END), a pituitary peptide released in increased concentrations during stress, can suppress the production of the key macrophage-activating lymphokine interferon-gamma (IFN-gamma) by cultured human peripheral blood mononuclear cells (PBMNC). Morphine 30-38 interferon gamma Homo sapiens 254-263 3040807-3 1987 Using a radioimmunoassay to measure IFN-gamma, we found that exposure of PBMNC to biologically relevant concentrations of both opioids significantly inhibited IFN-gamma generation by cells stimulated with concanavalin A and varicella zoster virus. pbmnc 73-78 interferon gamma Homo sapiens 36-45 3040807-3 1987 Using a radioimmunoassay to measure IFN-gamma, we found that exposure of PBMNC to biologically relevant concentrations of both opioids significantly inhibited IFN-gamma generation by cells stimulated with concanavalin A and varicella zoster virus. pbmnc 73-78 interferon gamma Homo sapiens 159-168 2955785-0 1987 Potential mechanisms of cytosolic calcium modulation in interferon-gamma treated U937 cells. Calcium 34-41 interferon gamma Homo sapiens 56-72 3105867-6 1987 In two cell lines with an induced resistance to mitomycin C, an increase in resistance to combined TNF-alpha and IFN-gamma treatment correlated with an increasing resistance to mitomycin C. Mitomycin 177-188 interferon gamma Homo sapiens 113-122 2884234-3 1987 In these experiments, we show that calcitriol also markedly inhibited production of the lymphokine, gamma interferon (IFN-gamma), by activated human T lymphocytes. Calcitriol 35-45 interferon gamma Homo sapiens 100-127 2439348-3 1987 Human interferon-gamma abolished the depolarizing effect of cyclosporin on lymphocytes. Cyclosporine 60-71 interferon gamma Homo sapiens 6-22 2884234-5 1987 The decrease in IL-2 and IFN-gamma mRNA that occurred with calcitriol treatment was coordinate and not apparent up to 12 h after phytohemagglutinin stimulation, whereas decreased accumulation of TfR mRNA was not present before 24-36 h. Furthermore, the effects of calcitriol on IL-2, IFN-gamma, and TfR mRNA accumulation were specific; actin mRNA accumulation was comparable between control and treated cells. Calcitriol 59-69 interferon gamma Homo sapiens 25-34 2884234-5 1987 The decrease in IL-2 and IFN-gamma mRNA that occurred with calcitriol treatment was coordinate and not apparent up to 12 h after phytohemagglutinin stimulation, whereas decreased accumulation of TfR mRNA was not present before 24-36 h. Furthermore, the effects of calcitriol on IL-2, IFN-gamma, and TfR mRNA accumulation were specific; actin mRNA accumulation was comparable between control and treated cells. Calcitriol 59-69 interferon gamma Homo sapiens 284-293 3112251-3 1987 Both [Cys-Tyr-Cys]rHu-IFN-gamma and [Cys-Tyr-Cys]rMu-IFN-gamma formed higher oligomers, tetramers, and octamers, respectively, under oxidative conditions, whereas rHu-IFN-gamma remained as dimers. Cysteine 6-9 interferon gamma Homo sapiens 22-31 3112251-3 1987 Both [Cys-Tyr-Cys]rHu-IFN-gamma and [Cys-Tyr-Cys]rMu-IFN-gamma formed higher oligomers, tetramers, and octamers, respectively, under oxidative conditions, whereas rHu-IFN-gamma remained as dimers. Tyr-Cys 10-17 interferon gamma Homo sapiens 22-31 3112251-3 1987 Both [Cys-Tyr-Cys]rHu-IFN-gamma and [Cys-Tyr-Cys]rMu-IFN-gamma formed higher oligomers, tetramers, and octamers, respectively, under oxidative conditions, whereas rHu-IFN-gamma remained as dimers. Cys-Tyr-Cys 6-17 interferon gamma Homo sapiens 22-31 3116404-4 1987 The induction of Interleukin-2, Interferon gamma and the Colony Stimulating Factor for granulocytes and macrophages was suppressed by Cyclosporin A at moderate concns. Cyclosporine 134-147 interferon gamma Homo sapiens 32-48 3109415-2 1987 Interferon-gamma (IFN-gamma) induced NBT-reducing activity only marginally. Nitroblue Tetrazolium 37-40 interferon gamma Homo sapiens 0-27 3109415-3 1987 However, when IFN-gamma was combined with TNF, induction of NBT-reducing activity was remarkably increased. Nitroblue Tetrazolium 60-63 interferon gamma Homo sapiens 14-23 3109415-5 1987 Treatment with both TNF and IFN-gamma synergistically enhanced morphological changes, growth inhibition and activity of Fc receptors, and NBT reduction in ML-1 cells, but not phagocytic activity. Nitroblue Tetrazolium 138-141 interferon gamma Homo sapiens 28-37 2955785-2 1987 This IFN-gamma-induced increase was reduced to 30-40% of basal (Ca2+) by the addition of diltiazem (1 microM) or incubation in Ca2+-free buffer. Diltiazem 89-98 interferon gamma Homo sapiens 5-14 3106184-5 1987 Addition of indomethacin to the cultures partially restored interferon-gamma production in patients with chronic active hepatitis and liver cirrhosis, indicating that suppressor function of monocytes was, in part, responsible for the diminished interferon-gamma production. Indomethacin 12-24 interferon gamma Homo sapiens 60-76 3106184-5 1987 Addition of indomethacin to the cultures partially restored interferon-gamma production in patients with chronic active hepatitis and liver cirrhosis, indicating that suppressor function of monocytes was, in part, responsible for the diminished interferon-gamma production. Indomethacin 12-24 interferon gamma Homo sapiens 245-261 3106491-3 1987 Inclusion of recombinant IFN-alpha or IFN-gamma during the pretreatment phase blocked subsequent prostaglandin release. Prostaglandins 97-110 interferon gamma Homo sapiens 38-47 3033646-1 1987 1 alpha,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], the biologically active metabolite of vitamin D3, inhibited synthesis of gamma-interferon (IFN-gamma) by phytohemagglutinin-activated peripheral blood lymphocytes (PBLs). Calcitriol 0-30 interferon gamma Homo sapiens 138-147 3033646-1 1987 1 alpha,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], the biologically active metabolite of vitamin D3, inhibited synthesis of gamma-interferon (IFN-gamma) by phytohemagglutinin-activated peripheral blood lymphocytes (PBLs). Calcitriol 32-44 interferon gamma Homo sapiens 138-147 3033646-1 1987 1 alpha,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], the biologically active metabolite of vitamin D3, inhibited synthesis of gamma-interferon (IFN-gamma) by phytohemagglutinin-activated peripheral blood lymphocytes (PBLs). Cholecalciferol 20-30 interferon gamma Homo sapiens 138-147 3036638-1 1987 Interferon-gamma (IFN-gamma) was induced from a human peripheral mononuclear fraction by incubation with a streptococcal preparation stabilized with penicillin G (OK432). Penicillin G 149-161 interferon gamma Homo sapiens 0-16 3033646-2 1987 A significant reduction of IFN-gamma protein levels in PBL culture medium was achieved with a physiologic 1,25-(OH)2D3 concentration (0.1 nM). Calcitriol 106-118 interferon gamma Homo sapiens 27-36 3033646-3 1987 1,25-(OH)2D3 also inhibited accumulation of IFN-gamma mRNA in activated PBLs in a dose-dependent fashion. Calcitriol 0-12 interferon gamma Homo sapiens 44-53 3033646-4 1987 The ability of 1,25-(OH)2D3 to modulate IFN-gamma protein synthesis was unaltered in the presence of high concentrations of recombinant human interleukin 2. Calcitriol 15-27 interferon gamma Homo sapiens 40-49 3033646-5 1987 The suppression of IFN-gamma synthesis by PBLs was specific for 1,25-(OH)2D3; the potencies of other vitamin D3 metabolites were correlated with their affinities for the cellular 1,25-(OH)2D3 receptor. Calcitriol 64-76 interferon gamma Homo sapiens 19-28 3033646-6 1987 The time course of 1,25-(OH)2D3 receptor expression in phytohemagglutinin-activated PBLs was correlated with the time course of 1,25-(OH)2D3-mediated inhibition of IFN-gamma synthesis. Calcitriol 19-31 interferon gamma Homo sapiens 164-173 3033646-11 1987 IFN-gamma synthesis by S-LB1 cells was inhibited in a dose-dependent fashion by 1,25-(OH)2D3, whereas IFN-gamma synthesis by Ab-VDR cells was not altered by 1,25-(OH)2D3. Calcitriol 80-92 interferon gamma Homo sapiens 0-9 3031123-4 1987 However, when TSH or DBcAMP was added after the cells had been cultured for 4 days with IFN gamma, T3 and thyroglobulin secretion in response to both 10 mU/mL TSH and 1 mM DBcAMP was significantly inhibited. Bucladesine 21-27 interferon gamma Homo sapiens 88-97 3115606-0 1987 Augmentation of antibody-dependent cellular cytotoxicity of polymorphonuclear leukocytes by interferon-gamma: mechanism dependent on enhancement of Fc receptor expression and increased release of activated oxygens. Oxygen 206-213 interferon gamma Homo sapiens 92-108 3036638-1 1987 Interferon-gamma (IFN-gamma) was induced from a human peripheral mononuclear fraction by incubation with a streptococcal preparation stabilized with penicillin G (OK432). Penicillin G 149-161 interferon gamma Homo sapiens 18-27 3036638-8 1987 Adenine arabinoside suppressed IFN-gamma-producing activity both in vivo and in vitro. Vidarabine 0-19 interferon gamma Homo sapiens 31-40 3112244-1 1987 Two lower-molecular-weight derivatives of recombinant human interferon-gamma (rIFN-gamma) were purified concurrently from a lysozyme-EDTA extract of Escherichia coli cells by immunoaffinity chromatography using a monoclonal antibody (MAb) against a synthetic carboxy-terminal peptide (Lys-131-Gln-146). Edetic Acid 133-137 interferon gamma Homo sapiens 60-76 3142217-5 1987 GMP-induced generation of natural CMC was potentiated by the addition of IFN-gamma and a monospecific anti IFN-gamma serum totally abrogated both IFN activity and CMC generation. cmc 34-37 interferon gamma Homo sapiens 73-82 3142217-5 1987 GMP-induced generation of natural CMC was potentiated by the addition of IFN-gamma and a monospecific anti IFN-gamma serum totally abrogated both IFN activity and CMC generation. cmc 34-37 interferon gamma Homo sapiens 107-116 3102606-4 1987 Appearance of the monocytic phenotype was manifested within 24 hr of IFN-gamma exposure by: increased nitroblue tetrazolium reduction; increased cell surface expression of the HLA-DR, Mo1, and MY4 antigens; and induction of transcripts for the second component of complement (C2) and tumor necrosis factor. Nitroblue Tetrazolium 102-123 interferon gamma Homo sapiens 69-78 3107985-3 1987 gamma-Irradiated cells produce, after exposure to cycloheximide, up to 12-fold greater amounts of IFN-gamma activity. Cycloheximide 50-63 interferon gamma Homo sapiens 98-107 3107985-8 1987 The superinductive effects of cycloheximide and gamma-irradiation on levels of IFN-gamma are additive, suggesting that they affect different aspects of IFN-gamma gene expression. Cycloheximide 30-43 interferon gamma Homo sapiens 79-88 3107985-8 1987 The superinductive effects of cycloheximide and gamma-irradiation on levels of IFN-gamma are additive, suggesting that they affect different aspects of IFN-gamma gene expression. Cycloheximide 30-43 interferon gamma Homo sapiens 152-161 3112244-1 1987 Two lower-molecular-weight derivatives of recombinant human interferon-gamma (rIFN-gamma) were purified concurrently from a lysozyme-EDTA extract of Escherichia coli cells by immunoaffinity chromatography using a monoclonal antibody (MAb) against a synthetic carboxy-terminal peptide (Lys-131-Gln-146). Lysine 285-288 interferon gamma Homo sapiens 60-76 3494429-8 1987 The association of PGE2 production with host antitumor response was evaluated in IFN-gamma therapy. Dinoprostone 19-23 interferon gamma Homo sapiens 81-90 3112244-1 1987 Two lower-molecular-weight derivatives of recombinant human interferon-gamma (rIFN-gamma) were purified concurrently from a lysozyme-EDTA extract of Escherichia coli cells by immunoaffinity chromatography using a monoclonal antibody (MAb) against a synthetic carboxy-terminal peptide (Lys-131-Gln-146). Glutamine 293-296 interferon gamma Homo sapiens 60-76 3110053-4 1987 Unlabeled lung carcinoma A-549 cells block chromium release from labeled K-562 cells with non-boosted and IFN-gamma or IFN-beta-boosted effector cells. Chromium 43-51 interferon gamma Homo sapiens 106-115 2949008-4 1987 Cross-linking of 125I-rHuIFN-gamma to platelet membrane proteins with the use of a bifunctional agent (DSS) yielded a predominant complex of 100,000 +/- 5,000 daltons on SDS-PAGE autoradiography, which confirms the presence of specific receptors for IFN-gamma. Sodium Dodecyl Sulfate 170-173 interferon gamma Homo sapiens 25-34 3026615-5 1987 Also, IFN-gamma neither induced differentiation of NTERA-2 cl.D1 cells, which are pluripotent human stem cells, nor influenced their differentiation induced by retinoic acid. Tretinoin 160-173 interferon gamma Homo sapiens 6-15 3107848-1 1987 The in vitro antiproliferative activity of human recombinant interferon-gamma (IFN-gamma) was tested against human tumor cells in vitro in combination with doxorubicin, cisplatin, or vinblastine. Doxorubicin 156-167 interferon gamma Homo sapiens 61-77 3152624-0 1987 Clinically used concentrations of cyclosporine A only partially inhibit interferon-gamma production by activated T lymphocytes. Cyclosporine 34-48 interferon gamma Homo sapiens 72-88 3037973-4 1987 However, ACTH and somatostatin, but not substance P, can also block the tumoricidal activity of macrophages induced by recombinant gamma interferon (IFN-gamma), a non-neuroendocrine immunomodulating hormone. acth 9-13 interferon gamma Homo sapiens 131-158 3109753-0 1987 Effects of recombinant human interferon-gamma (Met-Gln form) on expression of Fc receptor and Ia-like antigen on human peripheral monocytes and lymphocytes: a comparative study with natural human interferon-alpha and -beta. Glutamine 51-54 interferon gamma Homo sapiens 29-45 3108416-0 1987 Interferon-gamma potentiation of lipopolysaccharide-induced eicosanoid release from human monocytes. Eicosanoids 60-70 interferon gamma Homo sapiens 0-16 3108416-2 1987 The present investigation examined the capacity of IFN-gamma to modulate LPS-stimulated prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) release from counterflow isolated human monocytes. Dinoprostone 88-104 interferon gamma Homo sapiens 51-60 3108416-2 1987 The present investigation examined the capacity of IFN-gamma to modulate LPS-stimulated prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) release from counterflow isolated human monocytes. Dinoprostone 106-110 interferon gamma Homo sapiens 51-60 3108416-2 1987 The present investigation examined the capacity of IFN-gamma to modulate LPS-stimulated prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) release from counterflow isolated human monocytes. Thromboxane B2 116-130 interferon gamma Homo sapiens 51-60 3108416-4 1987 Treatment of cells with IFN-gamma prior to stimulation with LPS (10 micrograms/ml, Salmonella typhimurium) resulted in elevated prostaglandin E (by immunoassay) and [3H]PGE2 release from monocytes when compared with LPS-treated cultures. Prostaglandins E 128-143 interferon gamma Homo sapiens 24-33 3108416-4 1987 Treatment of cells with IFN-gamma prior to stimulation with LPS (10 micrograms/ml, Salmonella typhimurium) resulted in elevated prostaglandin E (by immunoassay) and [3H]PGE2 release from monocytes when compared with LPS-treated cultures. Tritium 166-168 interferon gamma Homo sapiens 24-33 3108416-4 1987 Treatment of cells with IFN-gamma prior to stimulation with LPS (10 micrograms/ml, Salmonella typhimurium) resulted in elevated prostaglandin E (by immunoassay) and [3H]PGE2 release from monocytes when compared with LPS-treated cultures. Dinoprostone 169-173 interferon gamma Homo sapiens 24-33 3108416-8 1987 These results indicate that IFN-gamma selectively potentiates LPS-stimulated arachidonic acid conversion to PGE2 and not TxB2 in human monocytes. Arachidonic Acid 77-93 interferon gamma Homo sapiens 28-37 3108416-8 1987 These results indicate that IFN-gamma selectively potentiates LPS-stimulated arachidonic acid conversion to PGE2 and not TxB2 in human monocytes. Dinoprostone 108-112 interferon gamma Homo sapiens 28-37 3107848-1 1987 The in vitro antiproliferative activity of human recombinant interferon-gamma (IFN-gamma) was tested against human tumor cells in vitro in combination with doxorubicin, cisplatin, or vinblastine. Cisplatin 169-178 interferon gamma Homo sapiens 61-77 3107848-1 1987 The in vitro antiproliferative activity of human recombinant interferon-gamma (IFN-gamma) was tested against human tumor cells in vitro in combination with doxorubicin, cisplatin, or vinblastine. Vinblastine 183-194 interferon gamma Homo sapiens 61-77 3107848-1 1987 The in vitro antiproliferative activity of human recombinant interferon-gamma (IFN-gamma) was tested against human tumor cells in vitro in combination with doxorubicin, cisplatin, or vinblastine. Vinblastine 183-194 interferon gamma Homo sapiens 79-88 3107848-6 1987 The results show that combinations of IFN-gamma with doxorubicin or cisplatin are additive and warrant further investigation. Doxorubicin 53-64 interferon gamma Homo sapiens 38-47 2828178-1 1987 Oligodeoxynucleotide (oligo)-directed mutagenesis was used to simultaneously delete the three intervening sequences (IVS) from the human interferon-gamma (IFN-gamma) gene. Oligodeoxyribonucleotides 0-20 interferon gamma Homo sapiens 155-164 3450546-2 1987 By incubation of monocytes with interferon-gamma, 12-O-tetradecanoylphorbol-13-acetate and lipopolysaccharide, antigen expression is decreased but strongly enhanced after incubation with dexamethasone. Dexamethasone 187-200 interferon gamma Homo sapiens 32-48 3100328-1 1987 A gene coding for human Val8-calcitonin (Val8-hCT) was synthesized by the solid-phase phosphite approach and fused to a synthetic human immune interferon-gamma (IFN-gamma) gene. val8-calcitonin 24-39 interferon gamma Homo sapiens 136-170 2828178-1 1987 Oligodeoxynucleotide (oligo)-directed mutagenesis was used to simultaneously delete the three intervening sequences (IVS) from the human interferon-gamma (IFN-gamma) gene. Oligodeoxyribonucleotides 0-20 interferon gamma Homo sapiens 137-153 2828178-1 1987 Oligodeoxynucleotide (oligo)-directed mutagenesis was used to simultaneously delete the three intervening sequences (IVS) from the human interferon-gamma (IFN-gamma) gene. Oligodeoxyribonucleotides 22-27 interferon gamma Homo sapiens 137-153 2828178-1 1987 Oligodeoxynucleotide (oligo)-directed mutagenesis was used to simultaneously delete the three intervening sequences (IVS) from the human interferon-gamma (IFN-gamma) gene. Oligodeoxyribonucleotides 22-27 interferon gamma Homo sapiens 155-164 2836672-2 1987 The effect of semipurified native interferon gamma (IFN gamma) on the differentiation-associated production of active oxygen intermediates was assessed by continuous exposure of the cells to IFN gamma or by adding it to the cultures at different stages of in vitro differentiation. Oxygen 118-124 interferon gamma Homo sapiens 34-50 2836672-2 1987 The effect of semipurified native interferon gamma (IFN gamma) on the differentiation-associated production of active oxygen intermediates was assessed by continuous exposure of the cells to IFN gamma or by adding it to the cultures at different stages of in vitro differentiation. Oxygen 118-124 interferon gamma Homo sapiens 52-61 2836672-2 1987 The effect of semipurified native interferon gamma (IFN gamma) on the differentiation-associated production of active oxygen intermediates was assessed by continuous exposure of the cells to IFN gamma or by adding it to the cultures at different stages of in vitro differentiation. Oxygen 118-124 interferon gamma Homo sapiens 191-200 2836672-6 1987 Zymosan-induced NBT reduction increased slightly during monocyte to macrophage differentiation and was further enhanced by continuous presence of IFN gamma. Zymosan 0-7 interferon gamma Homo sapiens 146-155 2836672-6 1987 Zymosan-induced NBT reduction increased slightly during monocyte to macrophage differentiation and was further enhanced by continuous presence of IFN gamma. Nitroblue Tetrazolium 16-19 interferon gamma Homo sapiens 146-155 2836672-8 1987 H2O2 secretion was greatly enhanced by the presence of IFN gamma and remained raised for at least 14 d. When added at intervals to spontaneously matured monocytes, IFN gamma had only modest and transient effects on the generation of intracellular O2- and H2O2. Hydrogen Peroxide 0-4 interferon gamma Homo sapiens 55-64 2836672-8 1987 H2O2 secretion was greatly enhanced by the presence of IFN gamma and remained raised for at least 14 d. When added at intervals to spontaneously matured monocytes, IFN gamma had only modest and transient effects on the generation of intracellular O2- and H2O2. Hydrogen Peroxide 0-4 interferon gamma Homo sapiens 164-173 2836672-8 1987 H2O2 secretion was greatly enhanced by the presence of IFN gamma and remained raised for at least 14 d. When added at intervals to spontaneously matured monocytes, IFN gamma had only modest and transient effects on the generation of intracellular O2- and H2O2. Oxygen 2-4 interferon gamma Homo sapiens 55-64 2836672-8 1987 H2O2 secretion was greatly enhanced by the presence of IFN gamma and remained raised for at least 14 d. When added at intervals to spontaneously matured monocytes, IFN gamma had only modest and transient effects on the generation of intracellular O2- and H2O2. Oxygen 2-4 interferon gamma Homo sapiens 164-173 2836672-8 1987 H2O2 secretion was greatly enhanced by the presence of IFN gamma and remained raised for at least 14 d. When added at intervals to spontaneously matured monocytes, IFN gamma had only modest and transient effects on the generation of intracellular O2- and H2O2. Hydrogen Peroxide 255-259 interferon gamma Homo sapiens 164-173 3331847-4 1987 1,25-(OH)2D3 decreases IL 2 and IFN-gamma synthesis by activated T lymphocytes in association with decreases in mRNA for these proteins. Calcitriol 0-12 interferon gamma Homo sapiens 32-41 3131870-7 1987 Prostaglandins produced by activated monocytes can block IL 2 and IFN gamma secretion. Prostaglandins 0-14 interferon gamma Homo sapiens 66-75 3331847-9 1987 Upon initiation of an immune response to a significant antigenic challenge 1,25-(OH)2D3 may, in concert with other suppressor mechanisms, limit the extent of the host response by inhibition of IL 2 and IFN-gamma production. Calcitriol 75-87 interferon gamma Homo sapiens 202-211 3096559-2 1986 Treatment with DFMO together with rec-IFN-gamma synergistically inhibited KO-RCC-1 cell growth in monolayer culture and in soft agar. Agar 128-132 interferon gamma Homo sapiens 38-47 3096559-5 1986 The polyamine content in KO-RCC-1 cells was decreased to a greater extent by combined treatment with DFMO and rec-IFN-gamma than that in Bewo and HT-1197 cells. Polyamines 4-13 interferon gamma Homo sapiens 114-123 3102242-1 1986 Human peripheral blood monocytes purified by counterflow elutriation were activated in vitro by human natural or recombinant interferon-gamma (IFN-gamma) as shown by enhanced killing of Listeria monocytogenes and increased production of H2O2 in response to phorbol myristate acetate. Tetradecanoylphorbol Acetate 257-282 interferon gamma Homo sapiens 125-141 3102242-1 1986 Human peripheral blood monocytes purified by counterflow elutriation were activated in vitro by human natural or recombinant interferon-gamma (IFN-gamma) as shown by enhanced killing of Listeria monocytogenes and increased production of H2O2 in response to phorbol myristate acetate. Tetradecanoylphorbol Acetate 257-282 interferon gamma Homo sapiens 143-152 3102242-1 1986 Human peripheral blood monocytes purified by counterflow elutriation were activated in vitro by human natural or recombinant interferon-gamma (IFN-gamma) as shown by enhanced killing of Listeria monocytogenes and increased production of H2O2 in response to phorbol myristate acetate. Hydrogen Peroxide 237-241 interferon gamma Homo sapiens 125-141 3106526-2 1986 Our study aimed at investigating the biosynthesis of unconjugated pterins in highly purified human macrophages and T lymphocytes before and during stimulation with supernatants of activated T cells or with recombinant human interferon-gamma (IFN-gamma) by monitoring the following parameters: substrate concentration (GTP, guanosine triphosphate), activity of the enzyme initiating the biosynthesis of pterins (GTP-cyclohydrolase I) and product concentrations of total neopterin, biopterin, and pterin. Pterins 66-72 interferon gamma Homo sapiens 224-240 3102242-1 1986 Human peripheral blood monocytes purified by counterflow elutriation were activated in vitro by human natural or recombinant interferon-gamma (IFN-gamma) as shown by enhanced killing of Listeria monocytogenes and increased production of H2O2 in response to phorbol myristate acetate. Hydrogen Peroxide 237-241 interferon gamma Homo sapiens 143-152 3106523-4 1986 [Gln25Lys78]IFN-gamma had two changes, at residue 25 (Asn to Gln) and residue 78 (Asn to Lys). gln25lys78 1-11 interferon gamma Homo sapiens 12-21 3106526-10 1986 Thus, it appears that IFN-gamma selectively stimulates the early steps of pterin biosynthesis in macrophages, thereby leading to accumulation and excretion of dihydroneopterin and neopterin. Pterins 74-80 interferon gamma Homo sapiens 22-31 3106523-5 1986 Another analog, [Cys-Tyr-Cys]IFN-gamma, incorporated Cys-Tyr-Cys at the amino terminus. Cys-Tyr-Cys 17-28 interferon gamma Homo sapiens 29-38 3106523-5 1986 Another analog, [Cys-Tyr-Cys]IFN-gamma, incorporated Cys-Tyr-Cys at the amino terminus. Cys-Tyr-Cys 53-64 interferon gamma Homo sapiens 29-38 3106526-10 1986 Thus, it appears that IFN-gamma selectively stimulates the early steps of pterin biosynthesis in macrophages, thereby leading to accumulation and excretion of dihydroneopterin and neopterin. 7,8-dihydroneopterin 159-175 interferon gamma Homo sapiens 22-31 3106525-2 1986 One preparation of CHO-derived IFN-gamma showed three bands, with the middle band being a doublet, in a SDS-polyacrylamide gel. cho 19-22 interferon gamma Homo sapiens 31-40 3106526-10 1986 Thus, it appears that IFN-gamma selectively stimulates the early steps of pterin biosynthesis in macrophages, thereby leading to accumulation and excretion of dihydroneopterin and neopterin. Neopterin 166-175 interferon gamma Homo sapiens 22-31 3106525-2 1986 One preparation of CHO-derived IFN-gamma showed three bands, with the middle band being a doublet, in a SDS-polyacrylamide gel. Sodium Dodecyl Sulfate 104-107 interferon gamma Homo sapiens 31-40 3106525-2 1986 One preparation of CHO-derived IFN-gamma showed three bands, with the middle band being a doublet, in a SDS-polyacrylamide gel. polyacrylamide 108-122 interferon gamma Homo sapiens 31-40 2944578-3 1986 Scatchard analysis with 125I-labeled human recombinant IFN-gamma revealed a similar binding affinity with a mean dissociation constant (Kd) of around 2 X 10(-11) M not only for various established cell lines, but also for leukemic and carcinoma cells derived from biopsy material. Iodine-125 24-28 interferon gamma Homo sapiens 55-64 3106525-5 1986 The circular dichroic (CD) spectra showed that conformation of the CHO-derived IFN-gamma is similar in the native state, in acid, and after renaturation from acid to the E. coli-derived IFN-gamma. cho 67-70 interferon gamma Homo sapiens 79-88 3106525-5 1986 The circular dichroic (CD) spectra showed that conformation of the CHO-derived IFN-gamma is similar in the native state, in acid, and after renaturation from acid to the E. coli-derived IFN-gamma. cho 67-70 interferon gamma Homo sapiens 186-195 3106526-0 1986 Interferon-gamma enhances biosynthesis of pterins in peripheral blood mononuclear cells by induction of GTP-cyclohydrolase I activity. Pterins 42-49 interferon gamma Homo sapiens 0-16 3106526-2 1986 Our study aimed at investigating the biosynthesis of unconjugated pterins in highly purified human macrophages and T lymphocytes before and during stimulation with supernatants of activated T cells or with recombinant human interferon-gamma (IFN-gamma) by monitoring the following parameters: substrate concentration (GTP, guanosine triphosphate), activity of the enzyme initiating the biosynthesis of pterins (GTP-cyclohydrolase I) and product concentrations of total neopterin, biopterin, and pterin. Pterins 66-73 interferon gamma Homo sapiens 224-240 2877026-0 1986 Second messenger role of arachidonic acid and its metabolites in interferon-gamma production. Arachidonic Acid 25-41 interferon gamma Homo sapiens 65-81 3120294-4 1987 Both interleukin-2 and leukotrienes enhance production of immune interferon (interferon-gamma) by activated T cells. Leukotrienes 23-35 interferon gamma Homo sapiens 77-93 3096330-2 1986 Both IFN-gamma and rTNF-alpha induced the appearance of the monocytic phenotype in a dose- and time-dependent manner as assessed by morphology, reduction of nitroblue tetrazolium and the induction of alpha-naphthyl butyrate esterase. Nitroblue Tetrazolium 157-178 interferon gamma Homo sapiens 5-14 3096332-1 1986 A three-day treatment with IFN-gamma enhanced up to 300% the capacity of human monocytes and macrophages to produce H2O2 during the respiratory burst. Hydrogen Peroxide 116-120 interferon gamma Homo sapiens 27-36 3103937-0 1986 Characteristics of augmentation of cell-mediated cytotoxic activities by recombinant human interferon-gamma (Met-Gln form): a comparative study with natural human interferon-alpha and -beta. memoquin 109-116 interferon gamma Homo sapiens 91-107 2944578-6 1986 Cross-linking of membrane-bound 125I-IFN-gamma with disuccinimidyl suberate and subsequent sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis revealed, in both leukemia and carcinoma cells, three distinct complexes with molecular weights of approximately 70,000, 92,000, and 160,000, suggesting the existence of IFN-gamma receptor subunits. disuccinimidyl 52-66 interferon gamma Homo sapiens 37-46 2944578-6 1986 Cross-linking of membrane-bound 125I-IFN-gamma with disuccinimidyl suberate and subsequent sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis revealed, in both leukemia and carcinoma cells, three distinct complexes with molecular weights of approximately 70,000, 92,000, and 160,000, suggesting the existence of IFN-gamma receptor subunits. Sodium Dodecyl Sulfate 91-113 interferon gamma Homo sapiens 37-46 2945777-4 1986 An increase in H2O2 production by monocyte monolayers was observed following the addition of either of these supernatants or IFN-gamma alone. Hydrogen Peroxide 15-19 interferon gamma Homo sapiens 125-134 3095231-0 1986 The influence of interferon-gamma and various phagocytic stimuli on the expression of MHC-class II antigens on human monocytes--relation to the generation of reactive oxygen intermediates. reactive 158-166 interferon gamma Homo sapiens 17-33 2945777-5 1986 In addition, a marked increase in the production of H2O2 was observed following priming with either of these mitogen-induced supernatants or IFN-gamma and the addition of a second stimulus, phorbol myristate acetate (PMA). Hydrogen Peroxide 52-56 interferon gamma Homo sapiens 141-150 3095231-0 1986 The influence of interferon-gamma and various phagocytic stimuli on the expression of MHC-class II antigens on human monocytes--relation to the generation of reactive oxygen intermediates. Oxygen 167-173 interferon gamma Homo sapiens 17-33 2945777-6 1986 Monoclonal antibody to IFN-gamma abrogated the increase in production of H2O2 by all these mitogen-induced supernatants; however, this antibody only resulted in partial inhibition of the leishmaniacidal effect of these lymphokines on human monocytes. Hydrogen Peroxide 73-77 interferon gamma Homo sapiens 23-32 2945777-7 1986 These results would suggest that IFN-gamma is the component of the lymphokine that is largely or exclusively responsible for H2O2 production, while other factors in addition to IFN-gamma are important in promoting oxygen-independent mechanisms for the killing of intracellular L. major amastigotes. Hydrogen Peroxide 125-129 interferon gamma Homo sapiens 33-42 3492436-3 1986 Neopterin is specifically released from human monocytes-macrophages after induction by interferon-gamma secreted from activated human T lymphocytes. Neopterin 0-9 interferon gamma Homo sapiens 87-103 2945777-7 1986 These results would suggest that IFN-gamma is the component of the lymphokine that is largely or exclusively responsible for H2O2 production, while other factors in addition to IFN-gamma are important in promoting oxygen-independent mechanisms for the killing of intracellular L. major amastigotes. Oxygen 214-220 interferon gamma Homo sapiens 177-186 3093595-5 1986 Restoration of IFN-gamma-induced DR antigen expression on monocytes in the presence of the patient"s sera was achieved by the addition of superoxide dismutase, 2-mercaptoethanol, or indomethacin. Mercaptoethanol 160-177 interferon gamma Homo sapiens 15-24 3097241-6 1986 Each rise of interferon gamma was followed by an increase of neopterin, but not every neopterin increase was preceded by a interferon gamma peak. Neopterin 61-70 interferon gamma Homo sapiens 13-29 3093530-4 1986 We suggest that these results indicate that the increased chemiluminescence activity (CL-A) of PBM in MS patients in remission is due mainly to the presence of circulating IFN-gamma. cl-a 86-90 interferon gamma Homo sapiens 172-181 2944612-0 1986 Histamine inhibits interferon-gamma production via suppression of interleukin 2 synthesis. Histamine 0-9 interferon gamma Homo sapiens 19-35 2944612-1 1986 Histamine, a modulator of various immune functions, inhibits the production of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) by polyclonally activated human blood mononuclear cells. Histamine 0-9 interferon gamma Homo sapiens 104-120 2944612-1 1986 Histamine, a modulator of various immune functions, inhibits the production of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) by polyclonally activated human blood mononuclear cells. Histamine 0-9 interferon gamma Homo sapiens 122-131 2944612-2 1986 The histamine-induced inhibition of IFN-gamma synthesis can be completely eliminated by the addition of recombinant IL-2. Histamine 4-13 interferon gamma Homo sapiens 36-45 2944612-4 1986 It is concluded that histamine acts primarily on the interleukin 2 synthesis by the T4+ lymphocytes and as a consequence of this inhibition, interferon-gamma production is reduced. Histamine 21-30 interferon gamma Homo sapiens 141-157 3093595-5 1986 Restoration of IFN-gamma-induced DR antigen expression on monocytes in the presence of the patient"s sera was achieved by the addition of superoxide dismutase, 2-mercaptoethanol, or indomethacin. Indomethacin 182-194 interferon gamma Homo sapiens 15-24 3093859-0 1986 Interferon-gamma suppresses the growth of Toxoplasma gondii in human fibroblasts through starvation for tryptophan. Tryptophan 104-114 interferon gamma Homo sapiens 0-16 2943796-4 1986 At a dexamethasone concentration of 200 nM, there was a twofold increase in the number of 125I-recombinant IFN-gamma molecules bound to the cell. Dexamethasone 5-18 interferon gamma Homo sapiens 107-116 2943796-7 1986 These results suggest that dexamethasone may modulate the effects of IFN-gamma on monocytes by changes in receptor number. Dexamethasone 27-40 interferon gamma Homo sapiens 69-78 3093859-4 1986 Within 24 h of treatment with IFN-gamma most of the tryptophan originally present in the medium is converted to these products together with some minor metabolites. Tryptophan 52-62 interferon gamma Homo sapiens 30-39 3093859-7 1986 Thus minor metabolites produced from tryptophan in response to IFN-gamma and excreted into the medium are not parasitostatic. Tryptophan 37-47 interferon gamma Homo sapiens 63-72 3093859-8 1986 When cultures treated with IFN-gamma for 24 h are incubated with medium that contains [3H]tryptophan, the radioactive amino acid is converted to N-formylkynurenine and kynurenine as rapidly as it enters the cell. [3h]tryptophan 86-100 interferon gamma Homo sapiens 27-36 3093859-8 1986 When cultures treated with IFN-gamma for 24 h are incubated with medium that contains [3H]tryptophan, the radioactive amino acid is converted to N-formylkynurenine and kynurenine as rapidly as it enters the cell. radioactive amino acid 106-128 interferon gamma Homo sapiens 27-36 2428037-5 1986 IDO thus induced in slices avidly metabolized tryptophan in situ: Upon a 24-hr incubation of lung slices pretreated with varied doses of IFN-gamma (10-10(3) units/ml), up to 96% of the tryptophan in the slices was depleted and up to 70% of the tryptophan in the medium was converted, mainly to formylkynurenine, kynurenine, or both. Tryptophan 46-56 interferon gamma Homo sapiens 137-146 3093859-8 1986 When cultures treated with IFN-gamma for 24 h are incubated with medium that contains [3H]tryptophan, the radioactive amino acid is converted to N-formylkynurenine and kynurenine as rapidly as it enters the cell. N'-formylkynurenine 145-163 interferon gamma Homo sapiens 27-36 2428037-5 1986 IDO thus induced in slices avidly metabolized tryptophan in situ: Upon a 24-hr incubation of lung slices pretreated with varied doses of IFN-gamma (10-10(3) units/ml), up to 96% of the tryptophan in the slices was depleted and up to 70% of the tryptophan in the medium was converted, mainly to formylkynurenine, kynurenine, or both. Tryptophan 185-195 interferon gamma Homo sapiens 137-146 2428037-5 1986 IDO thus induced in slices avidly metabolized tryptophan in situ: Upon a 24-hr incubation of lung slices pretreated with varied doses of IFN-gamma (10-10(3) units/ml), up to 96% of the tryptophan in the slices was depleted and up to 70% of the tryptophan in the medium was converted, mainly to formylkynurenine, kynurenine, or both. Tryptophan 185-195 interferon gamma Homo sapiens 137-146 3018738-5 1986 In addition to regulating the antigenic phenotype of these cells, both interferon gamma and GM-CSF had antiproliferative effects on SCLC lines as determined by [3H]thymidine incorporation and clonal growth in agar. Tritium 161-163 interferon gamma Homo sapiens 71-87 3093859-8 1986 When cultures treated with IFN-gamma for 24 h are incubated with medium that contains [3H]tryptophan, the radioactive amino acid is converted to N-formylkynurenine and kynurenine as rapidly as it enters the cell. Kynurenine 153-163 interferon gamma Homo sapiens 27-36 3018738-5 1986 In addition to regulating the antigenic phenotype of these cells, both interferon gamma and GM-CSF had antiproliferative effects on SCLC lines as determined by [3H]thymidine incorporation and clonal growth in agar. Agar 209-213 interferon gamma Homo sapiens 71-87 2428037-5 1986 IDO thus induced in slices avidly metabolized tryptophan in situ: Upon a 24-hr incubation of lung slices pretreated with varied doses of IFN-gamma (10-10(3) units/ml), up to 96% of the tryptophan in the slices was depleted and up to 70% of the tryptophan in the medium was converted, mainly to formylkynurenine, kynurenine, or both. N'-formylkynurenine 294-310 interferon gamma Homo sapiens 137-146 2428037-5 1986 IDO thus induced in slices avidly metabolized tryptophan in situ: Upon a 24-hr incubation of lung slices pretreated with varied doses of IFN-gamma (10-10(3) units/ml), up to 96% of the tryptophan in the slices was depleted and up to 70% of the tryptophan in the medium was converted, mainly to formylkynurenine, kynurenine, or both. Kynurenine 300-310 interferon gamma Homo sapiens 137-146 3093859-11 1986 The parasitostatic effect of IFN-gamma is most likely to result from the starvation of T. gondii for tryptophan. Tryptophan 101-111 interferon gamma Homo sapiens 29-38 3021873-1 1986 Concentrations of hydrocortisone as low as 0.08 microgram/ml significantly reduced the yields of gamma-interferon (IFN-gamma) when phytohemagglutinin (PHA) or concanavalin A (ConA) were used as inducers; however, when staphylococcal enterotoxin A was utilized, higher concentrations (5.0 micrograms/ml) were required to achieve the same effect. Hydrocortisone 18-32 interferon gamma Homo sapiens 115-124 3098477-6 1986 In fact, both the enhancement of Class I and Class II MHC antigen expression and the suppression of AML-2-23 antigen by IFN-gamma were often more profound in the presence of DEX. Dexamethasone 174-177 interferon gamma Homo sapiens 120-129 3098477-9 1986 On the contrary, DEX slightly augmented IFN-gamma effects on ADCC. Dexamethasone 17-20 interferon gamma Homo sapiens 40-49 3088114-3 1986 We therefore hypothesized that IFN-gamma may have MCS activity as well. mcs 50-53 interferon gamma Homo sapiens 31-40 3088117-0 1986 Effect of recombinant interferon-gamma on hydrogen peroxide-releasing capacity of monocyte-derived macrophages from patients with lepromatous leprosy. Hydrogen Peroxide 42-59 interferon gamma Homo sapiens 22-38 3095441-9 1986 We conclude that tryptophan degradation is an activity induced in vitro and in vivo in response to exogenous IFN-gamma but not to IFN-alpha or IFN-beta. Tryptophan 17-27 interferon gamma Homo sapiens 109-118 3095441-10 1986 Tryptophan degradation may play an important role in the mechanism of antiproliferative, immunologic, and clinical side effects of IFN-gamma. Tryptophan 0-10 interferon gamma Homo sapiens 131-140 3089830-2 1986 In these patients, bone marrow colony formation could be significantly enhanced by in vitro incubation of the bone marrow target with cyclosporin A (CyA; 0.5 microgram/ml) or with a monoclonal anti-gamma-(immune) interferon (IFN-gamma) antibody. Cyclosporine 134-147 interferon gamma Homo sapiens 225-234 3020587-0 1986 Stimulation of interleukin 2 and interferon gamma production by leukotriene B4 in human lymphocyte cultures. Leukotriene B4 64-78 interferon gamma Homo sapiens 33-49 3015908-1 1986 Murine immune interferon (Mu-IFN-gamma) can be radiolabeled with [gamma-32P]ATP by the catalytic subunit of cAMP-dependent protein kinase. [gamma-32p]atp 65-79 interferon gamma Homo sapiens 29-38 3015908-2 1986 The resulting 32P-labeled Mu-IFN-gamma (32P-Mu-IFN-gamma) with high radiological specific activity (60-260 muCi/micrograms) retains biological activity. Phosphorus-32 14-17 interferon gamma Homo sapiens 29-38 3015908-2 1986 The resulting 32P-labeled Mu-IFN-gamma (32P-Mu-IFN-gamma) with high radiological specific activity (60-260 muCi/micrograms) retains biological activity. Phosphorus-32 14-17 interferon gamma Homo sapiens 47-56 3015908-3 1986 Acid hydrolysis of 32P-Mu-IFN-gamma or 32P-labeled human IFN-gamma leads to the release of [32P]phosphoserine but not phosphothreonine or phosphotyrosine. Phosphorus-32 19-22 interferon gamma Homo sapiens 26-35 3015908-3 1986 Acid hydrolysis of 32P-Mu-IFN-gamma or 32P-labeled human IFN-gamma leads to the release of [32P]phosphoserine but not phosphothreonine or phosphotyrosine. Phosphorus-32 19-22 interferon gamma Homo sapiens 57-66 3015908-3 1986 Acid hydrolysis of 32P-Mu-IFN-gamma or 32P-labeled human IFN-gamma leads to the release of [32P]phosphoserine but not phosphothreonine or phosphotyrosine. Phosphorus-32 39-42 interferon gamma Homo sapiens 57-66 3015908-3 1986 Acid hydrolysis of 32P-Mu-IFN-gamma or 32P-labeled human IFN-gamma leads to the release of [32P]phosphoserine but not phosphothreonine or phosphotyrosine. Phosphorus-32 39-42 interferon gamma Homo sapiens 57-66 3015908-3 1986 Acid hydrolysis of 32P-Mu-IFN-gamma or 32P-labeled human IFN-gamma leads to the release of [32P]phosphoserine but not phosphothreonine or phosphotyrosine. Phosphoserine 96-109 interferon gamma Homo sapiens 26-35 3015908-3 1986 Acid hydrolysis of 32P-Mu-IFN-gamma or 32P-labeled human IFN-gamma leads to the release of [32P]phosphoserine but not phosphothreonine or phosphotyrosine. Phosphoserine 96-109 interferon gamma Homo sapiens 57-66 3015908-3 1986 Acid hydrolysis of 32P-Mu-IFN-gamma or 32P-labeled human IFN-gamma leads to the release of [32P]phosphoserine but not phosphothreonine or phosphotyrosine. Phosphothreonine 118-134 interferon gamma Homo sapiens 26-35 3015908-3 1986 Acid hydrolysis of 32P-Mu-IFN-gamma or 32P-labeled human IFN-gamma leads to the release of [32P]phosphoserine but not phosphothreonine or phosphotyrosine. Phosphothreonine 118-134 interferon gamma Homo sapiens 57-66 3015908-3 1986 Acid hydrolysis of 32P-Mu-IFN-gamma or 32P-labeled human IFN-gamma leads to the release of [32P]phosphoserine but not phosphothreonine or phosphotyrosine. Phosphotyrosine 138-153 interferon gamma Homo sapiens 26-35 3015908-3 1986 Acid hydrolysis of 32P-Mu-IFN-gamma or 32P-labeled human IFN-gamma leads to the release of [32P]phosphoserine but not phosphothreonine or phosphotyrosine. Phosphotyrosine 138-153 interferon gamma Homo sapiens 57-66 3088102-5 1986 Incubation with IFN-gamma increases Ia expression on M phi to 98% DR+, 75% DQ+, and 58% DP+ at 48 hr, with virtually all cells becoming positive for all three Ia antigens at 96 hr. dp 88-90 interferon gamma Homo sapiens 16-25 3088106-0 1986 Oxygen-independent inhibition of intracellular Chlamydia psittaci growth by human monocytes and interferon-gamma-activated macrophages. Oxygen 0-6 interferon gamma Homo sapiens 96-112 3088106-7 1986 The induction of this apparently oxygen-independent antichlamydial effect by lymphokine was completely neutralized by a monoclonal anti-IFN-gamma antibody, and could be achieved by treatment with recombinant (r)IFN-gamma alone. Oxygen 33-39 interferon gamma Homo sapiens 136-145 3088106-7 1986 The induction of this apparently oxygen-independent antichlamydial effect by lymphokine was completely neutralized by a monoclonal anti-IFN-gamma antibody, and could be achieved by treatment with recombinant (r)IFN-gamma alone. Oxygen 33-39 interferon gamma Homo sapiens 211-220 3021873-5 1986 Addition of the calcium ionophore A23187 partially restored IFN-gamma production. Calcium 16-23 interferon gamma Homo sapiens 60-69 3021873-5 1986 Addition of the calcium ionophore A23187 partially restored IFN-gamma production. Calcimycin 34-40 interferon gamma Homo sapiens 60-69 3021873-8 1986 Enhancement of the flux of calcium into the cell may restore some of the ability to produce IFN-gamma. Calcium 27-34 interferon gamma Homo sapiens 92-101 3088195-5 1986 Treatment of PHA-CM with mAb against either IFN-gamma or LT completely abrogated the colony-inhibiting activity, demonstrating a requirement for both lymphokines in PHA-CM-induced inhibition of CFU-GM. cfu-gm 194-200 interferon gamma Homo sapiens 44-53 3087883-2 1986 In recombinant IFN-gamma-treated cultures of human fibroblasts, tryptophan was undetectable in both the intracellular pool and the extracellular medium. Tryptophan 64-74 interferon gamma Homo sapiens 15-24 3087883-5 1986 Extracts prepared from IFN-gamma-treated human fibroblasts exhibited indoleamine 2,3-dioxygenase activity, converting tryptophan into products that cochromatographed with N-formylkynurenine and kynurenine; however, extracts prepared from untreated human fibroblasts, untreated L929 cells, recombinant IFN-gamma-treated L929 cells, and mouse lymphokine-treated L929 cells did not degrade tryptophan. Tryptophan 118-128 interferon gamma Homo sapiens 23-32 3087883-5 1986 Extracts prepared from IFN-gamma-treated human fibroblasts exhibited indoleamine 2,3-dioxygenase activity, converting tryptophan into products that cochromatographed with N-formylkynurenine and kynurenine; however, extracts prepared from untreated human fibroblasts, untreated L929 cells, recombinant IFN-gamma-treated L929 cells, and mouse lymphokine-treated L929 cells did not degrade tryptophan. N'-formylkynurenine 171-189 interferon gamma Homo sapiens 23-32 3087883-5 1986 Extracts prepared from IFN-gamma-treated human fibroblasts exhibited indoleamine 2,3-dioxygenase activity, converting tryptophan into products that cochromatographed with N-formylkynurenine and kynurenine; however, extracts prepared from untreated human fibroblasts, untreated L929 cells, recombinant IFN-gamma-treated L929 cells, and mouse lymphokine-treated L929 cells did not degrade tryptophan. Kynurenine 179-189 interferon gamma Homo sapiens 23-32 3087883-5 1986 Extracts prepared from IFN-gamma-treated human fibroblasts exhibited indoleamine 2,3-dioxygenase activity, converting tryptophan into products that cochromatographed with N-formylkynurenine and kynurenine; however, extracts prepared from untreated human fibroblasts, untreated L929 cells, recombinant IFN-gamma-treated L929 cells, and mouse lymphokine-treated L929 cells did not degrade tryptophan. Tryptophan 387-397 interferon gamma Homo sapiens 23-32 3087883-6 1986 Human HeLa cells resembled the human fibroblasts in that they degraded tryptophan after IFN-gamma treatment. Tryptophan 71-81 interferon gamma Homo sapiens 88-97 3087883-8 1986 Supplementation of the extracellular medium with additional tryptophan reconstituted the tryptophan pool in mock-infected and R. prowazekii-infected, X-irradiated, IFN-gamma-treated human fibroblasts to values greater than those observed in untreated control cultures. Tryptophan 60-70 interferon gamma Homo sapiens 164-173 3087883-8 1986 Supplementation of the extracellular medium with additional tryptophan reconstituted the tryptophan pool in mock-infected and R. prowazekii-infected, X-irradiated, IFN-gamma-treated human fibroblasts to values greater than those observed in untreated control cultures. Tryptophan 89-99 interferon gamma Homo sapiens 164-173 3093653-5 1986 The effect of IFN-gamma on DR and DQ was abrogated by prostaglandin E2 (PGE) while indomethacin, and inhibitor of PGE synthesis, mimicked the effect of IFN-gamma on DR and DQ expression. Dinoprostone 54-70 interferon gamma Homo sapiens 14-23 3093653-5 1986 The effect of IFN-gamma on DR and DQ was abrogated by prostaglandin E2 (PGE) while indomethacin, and inhibitor of PGE synthesis, mimicked the effect of IFN-gamma on DR and DQ expression. Dinoprostone 72-75 interferon gamma Homo sapiens 14-23 3093653-5 1986 The effect of IFN-gamma on DR and DQ was abrogated by prostaglandin E2 (PGE) while indomethacin, and inhibitor of PGE synthesis, mimicked the effect of IFN-gamma on DR and DQ expression. Indomethacin 83-95 interferon gamma Homo sapiens 152-161 3093653-5 1986 The effect of IFN-gamma on DR and DQ was abrogated by prostaglandin E2 (PGE) while indomethacin, and inhibitor of PGE synthesis, mimicked the effect of IFN-gamma on DR and DQ expression. Dinoprostone 114-117 interferon gamma Homo sapiens 152-161 3088310-3 1986 Differentiation of the RA-resistant variant could be induced by immune interferon (IFN-gamma) and a T-lymphocyte-derived lymphokine of a differentiation-inducing activity (DIA), alone or in combination with 10 nM RA. Tretinoin 23-25 interferon gamma Homo sapiens 83-92 3088195-7 1986 The inhibition observed using purified preparations of lymphokines shows that synergy between IFN-gamma and LT is sufficient to explain PHA-CM-induced inhibition of CFU-GM. cfu-gm 165-171 interferon gamma Homo sapiens 94-103 3011901-4 1986 We now report that, on stable transfection of the genomic human IFN-gamma 8.6 Kb BamH DNA fragment into a mouse T lymphoblast cell line, both mRNA expression and synthesis of human IFN-gamma were stimulated by both the physiologic ligand IL 2 and phorbol ester. Phorbol Esters 247-260 interferon gamma Homo sapiens 64-73 3011901-4 1986 We now report that, on stable transfection of the genomic human IFN-gamma 8.6 Kb BamH DNA fragment into a mouse T lymphoblast cell line, both mRNA expression and synthesis of human IFN-gamma were stimulated by both the physiologic ligand IL 2 and phorbol ester. Phorbol Esters 247-260 interferon gamma Homo sapiens 181-190 3097508-6 1986 Thus, although little mRNA 561 was synthesized in cells treated either with IFN-gamma alone or with IFN-alpha A and cycloheximide, a large quantity of this mRNA was induced in cells which had been pretreated with IFN-gamma and then treated with IFN-alpha A and cycloheximide. Cycloheximide 261-274 interferon gamma Homo sapiens 213-222 2427621-6 1986 These results suggest that the oligosaccharide side-chains of nIFN-gamma cover or perturb the structure of antigenic sites present in rIFN-gamma and thus significantly modify the antigenic properties of the IFN-gamma molecule. Oligosaccharides 31-46 interferon gamma Homo sapiens 63-72 2427623-1 1986 We have previously observed that gamma-interferon (IFN-gamma) inhibited the growth of the intracellular protozoan parasite Toxoplasma gondii in cultured human fibroblasts and that this inhibition was related to the disappearance of tryptophan from the medium with the concomitant appearance of kynurenine and N-formylkynurenine. Tryptophan 232-242 interferon gamma Homo sapiens 51-60 2427623-1 1986 We have previously observed that gamma-interferon (IFN-gamma) inhibited the growth of the intracellular protozoan parasite Toxoplasma gondii in cultured human fibroblasts and that this inhibition was related to the disappearance of tryptophan from the medium with the concomitant appearance of kynurenine and N-formylkynurenine. Kynurenine 294-304 interferon gamma Homo sapiens 51-60 2427623-1 1986 We have previously observed that gamma-interferon (IFN-gamma) inhibited the growth of the intracellular protozoan parasite Toxoplasma gondii in cultured human fibroblasts and that this inhibition was related to the disappearance of tryptophan from the medium with the concomitant appearance of kynurenine and N-formylkynurenine. N'-formylkynurenine 309-327 interferon gamma Homo sapiens 51-60 2427623-2 1986 In this report, we show that IFN-gamma induced an indoleamine 2,3-dioxygenase in human fibroblasts that converts tryptophan to N-formylkynurenine. Tryptophan 113-123 interferon gamma Homo sapiens 29-38 2427623-2 1986 In this report, we show that IFN-gamma induced an indoleamine 2,3-dioxygenase in human fibroblasts that converts tryptophan to N-formylkynurenine. N'-formylkynurenine 127-145 interferon gamma Homo sapiens 29-38 2427623-5 1986 The induction of indoleamine 2,3-dioxygenase by IFN-gamma was inhibited by treatment of the cultures with either actinomycin D or cycloheximide, and thus was dependent on both RNA and protein synthesis. Dactinomycin 113-126 interferon gamma Homo sapiens 48-57 2427623-5 1986 The induction of indoleamine 2,3-dioxygenase by IFN-gamma was inhibited by treatment of the cultures with either actinomycin D or cycloheximide, and thus was dependent on both RNA and protein synthesis. Cycloheximide 130-143 interferon gamma Homo sapiens 48-57 2427623-6 1986 The indoleamine 2,3-dioxygenase induced by IFN-gamma appeared to differ from other mammalian enzymes that degrade tryptophan. Tryptophan 114-124 interferon gamma Homo sapiens 43-52 3010706-0 1986 Burkitt"s cells can be triggered by teleocidin to secrete interferon-gamma. teleocidins 36-46 interferon gamma Homo sapiens 58-74 3010706-3 1986 IFN-gamma has not been detected in any of the 25 cell lines studied, and following stimulation with teleocidin, we triggered the synthesis of IFN-gamma in JLP(C), a pre-Burkitt"s cell line. teleocidins 100-110 interferon gamma Homo sapiens 142-151 3084656-3 1986 H2O2 production was determined during in vitro culture and in response to bacterial lipopolysaccharide (LPS), and to recombinant human interferon-gamma (rIFN-gamma). Hydrogen Peroxide 0-4 interferon gamma Homo sapiens 135-151 3010991-1 1986 Recombinant human interferon-gamma was phosphorylated with ATP and c-AMP-dependent protein kinase. Adenosine Triphosphate 59-62 interferon gamma Homo sapiens 18-34 3084257-8 1986 It remains to be established to what extent the carbohydrate chains of this biotechnologically produced IFN-gamma are identical to those of naturally occurring human IFN-gamma. Carbohydrates 48-60 interferon gamma Homo sapiens 104-113 3084562-4 1986 Natural IFN-gamma in the TPA-Con A CM and rIFN-gamma (12.5-500 U/ml) induced major histocompatibility complex-class II antigens (HLA-DR, HLA-DP, and HLA-DQ) and significant lymphocyte adhesion to the EC, whereas rIFN-alpha did not. Tetradecanoylphorbol Acetate 25-28 interferon gamma Homo sapiens 8-17 3010991-2 1986 After phosphorylation, interferon-gamma was separated from the adenosine phosphates and the kinase and analyzed by SDS-PAGE, reverse phase HPLC, and HPLC peptide mapping. Adenine Nucleotides 63-83 interferon gamma Homo sapiens 23-39 3010991-2 1986 After phosphorylation, interferon-gamma was separated from the adenosine phosphates and the kinase and analyzed by SDS-PAGE, reverse phase HPLC, and HPLC peptide mapping. Sodium Dodecyl Sulfate 115-118 interferon gamma Homo sapiens 23-39 3007500-3 1986 TNF-R expression was significantly increased after 6 h of exposure to IFN-gamma (100 units/ml), and it remained elevated in the continuous presence of IFN-gamma for at least 20 h. Incubation of cells with IFN-gamma in the presence of cycloheximide, followed by treatment with actinomycin D and reversal of the inhibition of protein synthesis, also resulted in increased TNF-R expression as compared to cultures subjected to the same treatments in the absence of IFN-gamma. Dactinomycin 276-289 interferon gamma Homo sapiens 151-160 3007500-3 1986 TNF-R expression was significantly increased after 6 h of exposure to IFN-gamma (100 units/ml), and it remained elevated in the continuous presence of IFN-gamma for at least 20 h. Incubation of cells with IFN-gamma in the presence of cycloheximide, followed by treatment with actinomycin D and reversal of the inhibition of protein synthesis, also resulted in increased TNF-R expression as compared to cultures subjected to the same treatments in the absence of IFN-gamma. Cycloheximide 234-247 interferon gamma Homo sapiens 70-79 3087039-0 1986 Relationship of interferon-gamma and neopterin levels during stimulation with alloantigens in vivo and in vitro. Neopterin 37-46 interferon gamma Homo sapiens 16-32 3007500-3 1986 TNF-R expression was significantly increased after 6 h of exposure to IFN-gamma (100 units/ml), and it remained elevated in the continuous presence of IFN-gamma for at least 20 h. Incubation of cells with IFN-gamma in the presence of cycloheximide, followed by treatment with actinomycin D and reversal of the inhibition of protein synthesis, also resulted in increased TNF-R expression as compared to cultures subjected to the same treatments in the absence of IFN-gamma. Dactinomycin 276-289 interferon gamma Homo sapiens 151-160 3087039-1 1986 We have recently shown that interferon-gamma is capable of activating the key enzyme of pterin biosynthesis in macrophages. Pterins 88-94 interferon gamma Homo sapiens 28-44 3007500-3 1986 TNF-R expression was significantly increased after 6 h of exposure to IFN-gamma (100 units/ml), and it remained elevated in the continuous presence of IFN-gamma for at least 20 h. Incubation of cells with IFN-gamma in the presence of cycloheximide, followed by treatment with actinomycin D and reversal of the inhibition of protein synthesis, also resulted in increased TNF-R expression as compared to cultures subjected to the same treatments in the absence of IFN-gamma. Cycloheximide 234-247 interferon gamma Homo sapiens 151-160 3007500-3 1986 TNF-R expression was significantly increased after 6 h of exposure to IFN-gamma (100 units/ml), and it remained elevated in the continuous presence of IFN-gamma for at least 20 h. Incubation of cells with IFN-gamma in the presence of cycloheximide, followed by treatment with actinomycin D and reversal of the inhibition of protein synthesis, also resulted in increased TNF-R expression as compared to cultures subjected to the same treatments in the absence of IFN-gamma. Cycloheximide 234-247 interferon gamma Homo sapiens 151-160 3087039-6 1986 (2) Detection of interferon-gamma in sera of allograft recipients invariably precedes an increase of neopterin; on the other hand, increasing neopterin counts are also seen in the absence of detectable interferon-gamma levels in the serum. Neopterin 101-110 interferon gamma Homo sapiens 17-33 3082979-5 1986 In addition, IFN-gamma increased H2O2 production from human monocytes in culture in a dose-dependent manner. Hydrogen Peroxide 33-37 interferon gamma Homo sapiens 13-22 3007500-3 1986 TNF-R expression was significantly increased after 6 h of exposure to IFN-gamma (100 units/ml), and it remained elevated in the continuous presence of IFN-gamma for at least 20 h. Incubation of cells with IFN-gamma in the presence of cycloheximide, followed by treatment with actinomycin D and reversal of the inhibition of protein synthesis, also resulted in increased TNF-R expression as compared to cultures subjected to the same treatments in the absence of IFN-gamma. Cycloheximide 234-247 interferon gamma Homo sapiens 151-160 3007500-3 1986 TNF-R expression was significantly increased after 6 h of exposure to IFN-gamma (100 units/ml), and it remained elevated in the continuous presence of IFN-gamma for at least 20 h. Incubation of cells with IFN-gamma in the presence of cycloheximide, followed by treatment with actinomycin D and reversal of the inhibition of protein synthesis, also resulted in increased TNF-R expression as compared to cultures subjected to the same treatments in the absence of IFN-gamma. Dactinomycin 276-289 interferon gamma Homo sapiens 151-160 3082979-6 1986 Monoclonal antibody to IFN-gamma abrogated both its effect on the leishmaniacidal capacity and on H2O2 production by the monocytes. Hydrogen Peroxide 98-102 interferon gamma Homo sapiens 23-32 3081678-2 1986 IFN-gamma mRNA levels in human neonatal blood mononuclear cells or highly purified T cells were markedly lower than those of adult cells after incubation with Con A and PMA. Tetradecanoylphorbol Acetate 169-172 interferon gamma Homo sapiens 0-9 3081254-4 1986 In contrast, the lethal effect of the combination of IFN-gamma and poly(I).poly(C) was synergistic and this regimen produced a 40 to 80% reduction in colony formation. Poly C 75-82 interferon gamma Homo sapiens 53-62 3081254-6 1986 The concentration of the dsRNAs producing a 50% decrease in cell viability in combination with IFN-gamma (100 units/ml) was 6 micrograms/ml for poly(I).poly(C), 1 microgram/ml for poly(A).poly(U), 3 ng/ml for poly(ICLC), and 16 micrograms/ml for rIn.r(C13,U)n. DNA, RNA, and protein synthesis in IFN-gamma and poly(I).poly(C)-treated cells were reduced in a dose-dependent manner. Poly A 144-148 interferon gamma Homo sapiens 95-104 3081254-6 1986 The concentration of the dsRNAs producing a 50% decrease in cell viability in combination with IFN-gamma (100 units/ml) was 6 micrograms/ml for poly(I).poly(C), 1 microgram/ml for poly(A).poly(U), 3 ng/ml for poly(ICLC), and 16 micrograms/ml for rIn.r(C13,U)n. DNA, RNA, and protein synthesis in IFN-gamma and poly(I).poly(C)-treated cells were reduced in a dose-dependent manner. Poly C 152-159 interferon gamma Homo sapiens 95-104 3088147-6 1986 In contrast to IFN-beta 2 mRNA, cycloheximide treatment of lymphocytes produced a slight accumulation of IFN-gamma mRNA. Cycloheximide 32-45 interferon gamma Homo sapiens 105-114 2936824-1 1986 The purpose of this study was to identify the mechanism by which muramyl dipeptide (MDP) activates antitumor cytotoxic properties in normal and interferon-gamma (IFN-gamma)-primed human peripheral blood monocytes. Acetylmuramyl-Alanyl-Isoglutamine 65-82 interferon gamma Homo sapiens 144-160 3086215-0 1986 Calcium ionophore A 23 187 in the presence of phorbol ester PMA: a potent inducer of interleukin 2 and interferon-gamma synthesis by human blood cells. Calcium 0-7 interferon gamma Homo sapiens 103-119 3086215-1 1986 Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA. Calcium 61-68 interferon gamma Homo sapiens 233-249 3086215-1 1986 Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA. Calcium 61-68 interferon gamma Homo sapiens 251-260 3086215-1 1986 Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA. Tetradecanoylphorbol Acetate 126-157 interferon gamma Homo sapiens 233-249 3086215-1 1986 Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA. Tetradecanoylphorbol Acetate 126-157 interferon gamma Homo sapiens 251-260 3086215-1 1986 Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA. Tetradecanoylphorbol Acetate 159-162 interferon gamma Homo sapiens 233-249 3086215-1 1986 Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA. Tetradecanoylphorbol Acetate 159-162 interferon gamma Homo sapiens 251-260 2936824-1 1986 The purpose of this study was to identify the mechanism by which muramyl dipeptide (MDP) activates antitumor cytotoxic properties in normal and interferon-gamma (IFN-gamma)-primed human peripheral blood monocytes. Acetylmuramyl-Alanyl-Isoglutamine 65-82 interferon gamma Homo sapiens 162-171 2936824-1 1986 The purpose of this study was to identify the mechanism by which muramyl dipeptide (MDP) activates antitumor cytotoxic properties in normal and interferon-gamma (IFN-gamma)-primed human peripheral blood monocytes. Acetylmuramyl-Alanyl-Isoglutamine 84-87 interferon gamma Homo sapiens 144-160 2936824-1 1986 The purpose of this study was to identify the mechanism by which muramyl dipeptide (MDP) activates antitumor cytotoxic properties in normal and interferon-gamma (IFN-gamma)-primed human peripheral blood monocytes. Acetylmuramyl-Alanyl-Isoglutamine 84-87 interferon gamma Homo sapiens 162-171 2936824-5 1986 Subthreshold concentrations of nor-MDP could activate tumor cytotoxic properties in IFN-gamma-primed monocytes. UNII-1DCO35D4OR 31-38 interferon gamma Homo sapiens 84-93 2936824-6 1986 The intracellular interaction of [3H]nor-MDP with IFN-gamma-primed monocytes was specific in that intracellular levels of radiolabeled material could be displaced and recovered as intact molecules by unlabeled nor-MDP, but not by a biologically inactive MDP stereoisomer. Tritium 34-36 interferon gamma Homo sapiens 50-59 2936824-6 1986 The intracellular interaction of [3H]nor-MDP with IFN-gamma-primed monocytes was specific in that intracellular levels of radiolabeled material could be displaced and recovered as intact molecules by unlabeled nor-MDP, but not by a biologically inactive MDP stereoisomer. Acetylmuramyl-Alanyl-Isoglutamine 40-44 interferon gamma Homo sapiens 50-59 2936824-6 1986 The intracellular interaction of [3H]nor-MDP with IFN-gamma-primed monocytes was specific in that intracellular levels of radiolabeled material could be displaced and recovered as intact molecules by unlabeled nor-MDP, but not by a biologically inactive MDP stereoisomer. UNII-1DCO35D4OR 37-44 interferon gamma Homo sapiens 50-59 3081575-10 1986 Addition of IFN alpha, 10,000-50,000 U/ml of interleukin 2 or phorbol myristate acetate (PMA) to cord mononuclear cells or of adult monocytes or PMA to cord T cells increased IFN gamma production compared to cells stimulated with concanavalin A (ConA) alone. Tetradecanoylphorbol Acetate 62-87 interferon gamma Homo sapiens 175-184 3081641-6 1986 Cycloheximide inhibits the induction of the invariant chain mRNA by interferon-gamma, suggesting that protein synthesis is required. Cycloheximide 0-13 interferon gamma Homo sapiens 68-84 3005410-1 1986 Incubation of several human tumor cell lines with human interferon-gamma (IFN-gamma) increased the specific binding of subsequently added 125I-labeled recombinant human tumor necrosis factor (TNF). Iodine-125 138-142 interferon gamma Homo sapiens 56-72 3005410-1 1986 Incubation of several human tumor cell lines with human interferon-gamma (IFN-gamma) increased the specific binding of subsequently added 125I-labeled recombinant human tumor necrosis factor (TNF). Iodine-125 138-142 interferon gamma Homo sapiens 74-83 2416427-3 1986 In all cell lines except one, the addition of IFN-gamma to either IFN-alpha 54 or IFN-beta ser resulted in a synergistic antiproliferative effect, regardless of individual IFN sensitivities or tissue of origin. Serine 91-94 interferon gamma Homo sapiens 46-55 3017576-4 1986 A 3-day preincubation with IFN-gamma or 1 alpha,25(OH)2D3 resulted in a 5- to 10-fold increase in PMA-stimulated production of O2- as compared to cells preincubated in medium alone. Tetradecanoylphorbol Acetate 98-101 interferon gamma Homo sapiens 27-36 3017576-4 1986 A 3-day preincubation with IFN-gamma or 1 alpha,25(OH)2D3 resulted in a 5- to 10-fold increase in PMA-stimulated production of O2- as compared to cells preincubated in medium alone. Superoxides 127-129 interferon gamma Homo sapiens 27-36 3080754-1 1986 The effects of glycyrrhizin, a component of licorice (Glycyrrhiza glabra) roots, on the production of interferon-gamma in human peripheral lymphocyte-macrophage cultures by concanavalin A (Con A) was examined. Glycyrrhizic Acid 15-27 interferon gamma Homo sapiens 102-118 3080754-2 1986 Interferon-gamma production in normal lymphocyte-macrophage cultures treated with 10 to 100 micrograms/ml of glycyrrhizin at 37 degrees C for 12 hr or longer, and then treated with 10 micrograms/ml of Con A, was enhanced four to eight times compared to control cell cultures. Glycyrrhizic Acid 109-121 interferon gamma Homo sapiens 0-16 3080754-5 1986 Collaboration between enriched T-lymphocytes and macrophages, both treated with glycyrrhizin, was needed for the enhancement of interferon-gamma production. Glycyrrhizic Acid 80-92 interferon gamma Homo sapiens 128-144 2936804-6 1986 Monoclonal and polyclonal antibodies to interferon-gamma could abrogate the inhibitory effects of SMAA supernatant, but more than 10(4) neutralizing U/ml had to be added. smaa 98-102 interferon gamma Homo sapiens 40-56 3080326-5 1986 HL-60 cells treated with 100 U/ml IFN-G had an eightfold increase in expression of nonspecific esterase (NSE) and a twofold increase in H2O2 production in response to phorbol myristate acetate (PMA). Hydrogen Peroxide 136-140 interferon gamma Homo sapiens 34-39 3080326-5 1986 HL-60 cells treated with 100 U/ml IFN-G had an eightfold increase in expression of nonspecific esterase (NSE) and a twofold increase in H2O2 production in response to phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 167-192 interferon gamma Homo sapiens 34-39 3080326-5 1986 HL-60 cells treated with 100 U/ml IFN-G had an eightfold increase in expression of nonspecific esterase (NSE) and a twofold increase in H2O2 production in response to phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 194-197 interferon gamma Homo sapiens 34-39 3080754-0 1986 Enhancement of interferon-gamma production in glycyrrhizin-treated human peripheral lymphocytes in response to concanavalin A and to surface antigen of hepatitis B virus. Glycyrrhizic Acid 46-58 interferon gamma Homo sapiens 15-31 3102389-0 1986 Peroxide and pteridine: a hypothesis on the regulation of macrophage antimicrobial activity by interferon gamma. Peroxides 0-8 interferon gamma Homo sapiens 95-111 3090949-8 1986 A 5-min pretreatment with IFN gamma decreased the ZAS response but did not affect the reaction to the other stimuli. ZAS 50-53 interferon gamma Homo sapiens 26-35 3002968-4 1986 Because dihydroxy vitamin D3 (1,25-(OH)2 D3) can cause phenotypic differentiation of immature leukemic lines into macrophage-like cells, we have explored the possibility that exposure to cholecalciferol metabolites in vitro might increase the ability of monocytes to control proliferation of M. tuberculosis, or cause monocytes to mature into cells able to respond appropriately to IFN-gamma. Cholecalciferol 187-202 interferon gamma Homo sapiens 382-391 3002968-8 1986 Monocytes incubated with IFN-gamma developed 25-OH D3 1-hydroxylase activity, detected by conversion of tritiated 25-(OH) D3 to a more polar metabolite which coeluted with 1,25-(OH)2 D3 on straight and reverse-phase HPLC. Calcifediol 114-124 interferon gamma Homo sapiens 25-34 3102389-0 1986 Peroxide and pteridine: a hypothesis on the regulation of macrophage antimicrobial activity by interferon gamma. Pteridines 13-22 interferon gamma Homo sapiens 95-111 2934742-1 1986 When 32P-labeled human recombinant immune interferon gamma (Hu-[32P]IFN-gamma) is crosslinked to human cells with disuccinimidyl suberate, a complex with a molecular size of approximately equal to 117,000 Da was identified by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. Phosphorus-32 5-8 interferon gamma Homo sapiens 68-77 2934742-1 1986 When 32P-labeled human recombinant immune interferon gamma (Hu-[32P]IFN-gamma) is crosslinked to human cells with disuccinimidyl suberate, a complex with a molecular size of approximately equal to 117,000 Da was identified by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. Phosphorus-32 64-67 interferon gamma Homo sapiens 68-77 2934742-1 1986 When 32P-labeled human recombinant immune interferon gamma (Hu-[32P]IFN-gamma) is crosslinked to human cells with disuccinimidyl suberate, a complex with a molecular size of approximately equal to 117,000 Da was identified by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. disuccinimidyl 114-128 interferon gamma Homo sapiens 68-77 2934742-1 1986 When 32P-labeled human recombinant immune interferon gamma (Hu-[32P]IFN-gamma) is crosslinked to human cells with disuccinimidyl suberate, a complex with a molecular size of approximately equal to 117,000 Da was identified by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. Sodium Dodecyl Sulfate 226-248 interferon gamma Homo sapiens 68-77 2934742-1 1986 When 32P-labeled human recombinant immune interferon gamma (Hu-[32P]IFN-gamma) is crosslinked to human cells with disuccinimidyl suberate, a complex with a molecular size of approximately equal to 117,000 Da was identified by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. polyacrylamide 249-263 interferon gamma Homo sapiens 68-77 2934408-8 1985 Monocytes degraded 125I-IFN gamma into trichloroacetic acid-soluble counts at 37 degrees C but not at 4 degrees C, at an approximate rate of 5,000 molecules/cell per h. The receptor was partially characterized by SDS-polyacrylamide gel electrophoresis analysis of purified U937 membranes that had been incubated with 125I-IFN gamma. Trichloroacetic Acid 39-59 interferon gamma Homo sapiens 24-33 2948099-4 1986 Effective IFN-gamma production seems to require participation of plastic-adherent cells (presumably monocytes), while the addition of cyclosporin A (CyA) almost completely blocked generation of human IFN-gamma. Cyclosporine 134-147 interferon gamma Homo sapiens 200-209 2948099-9 1986 Lastly, OK432, glycyrrhizin, and CCA (lobenzarit disodium) increase the number of IFN-gamma containing cells and are thought to be immunomodulators. Glycyrrhizic Acid 15-27 interferon gamma Homo sapiens 82-91 2948099-9 1986 Lastly, OK432, glycyrrhizin, and CCA (lobenzarit disodium) increase the number of IFN-gamma containing cells and are thought to be immunomodulators. lobenzarit 38-57 interferon gamma Homo sapiens 82-91 3093801-0 1986 Nickel chelate chromatography of human immune interferon. Nickel 0-6 interferon gamma Homo sapiens 39-56 3093810-0 1986 Induction of human interferon gamma with phorbol esters and phytohemagglutinin. Phorbol Esters 41-55 interferon gamma Homo sapiens 19-35 3099131-3 1986 Using this improved method we demonstrated that reagents such as 12-O-tetradecanoylphorbol-13-acetate (TPA), concanavalin A (Con A) and a calcium ionophore (A23187) could induce the expression of IFN-gamma gene of a human T-lymphoblastoid cell line, TCL-Fuj 2M, where TPA functioned synergistically with Con A and A23187. Tetradecanoylphorbol Acetate 65-101 interferon gamma Homo sapiens 196-205 3099131-3 1986 Using this improved method we demonstrated that reagents such as 12-O-tetradecanoylphorbol-13-acetate (TPA), concanavalin A (Con A) and a calcium ionophore (A23187) could induce the expression of IFN-gamma gene of a human T-lymphoblastoid cell line, TCL-Fuj 2M, where TPA functioned synergistically with Con A and A23187. Tetradecanoylphorbol Acetate 103-106 interferon gamma Homo sapiens 196-205 3099131-3 1986 Using this improved method we demonstrated that reagents such as 12-O-tetradecanoylphorbol-13-acetate (TPA), concanavalin A (Con A) and a calcium ionophore (A23187) could induce the expression of IFN-gamma gene of a human T-lymphoblastoid cell line, TCL-Fuj 2M, where TPA functioned synergistically with Con A and A23187. Calcium 138-145 interferon gamma Homo sapiens 196-205 3099131-3 1986 Using this improved method we demonstrated that reagents such as 12-O-tetradecanoylphorbol-13-acetate (TPA), concanavalin A (Con A) and a calcium ionophore (A23187) could induce the expression of IFN-gamma gene of a human T-lymphoblastoid cell line, TCL-Fuj 2M, where TPA functioned synergistically with Con A and A23187. Calcimycin 157-163 interferon gamma Homo sapiens 196-205 3099131-3 1986 Using this improved method we demonstrated that reagents such as 12-O-tetradecanoylphorbol-13-acetate (TPA), concanavalin A (Con A) and a calcium ionophore (A23187) could induce the expression of IFN-gamma gene of a human T-lymphoblastoid cell line, TCL-Fuj 2M, where TPA functioned synergistically with Con A and A23187. Tetradecanoylphorbol Acetate 268-271 interferon gamma Homo sapiens 196-205 3099131-3 1986 Using this improved method we demonstrated that reagents such as 12-O-tetradecanoylphorbol-13-acetate (TPA), concanavalin A (Con A) and a calcium ionophore (A23187) could induce the expression of IFN-gamma gene of a human T-lymphoblastoid cell line, TCL-Fuj 2M, where TPA functioned synergistically with Con A and A23187. Calcimycin 314-320 interferon gamma Homo sapiens 196-205 2934408-8 1985 Monocytes degraded 125I-IFN gamma into trichloroacetic acid-soluble counts at 37 degrees C but not at 4 degrees C, at an approximate rate of 5,000 molecules/cell per h. The receptor was partially characterized by SDS-polyacrylamide gel electrophoresis analysis of purified U937 membranes that had been incubated with 125I-IFN gamma. Sodium Dodecyl Sulfate 213-216 interferon gamma Homo sapiens 24-33 2934408-8 1985 Monocytes degraded 125I-IFN gamma into trichloroacetic acid-soluble counts at 37 degrees C but not at 4 degrees C, at an approximate rate of 5,000 molecules/cell per h. The receptor was partially characterized by SDS-polyacrylamide gel electrophoresis analysis of purified U937 membranes that had been incubated with 125I-IFN gamma. Sodium Dodecyl Sulfate 213-216 interferon gamma Homo sapiens 322-331 2934408-8 1985 Monocytes degraded 125I-IFN gamma into trichloroacetic acid-soluble counts at 37 degrees C but not at 4 degrees C, at an approximate rate of 5,000 molecules/cell per h. The receptor was partially characterized by SDS-polyacrylamide gel electrophoresis analysis of purified U937 membranes that had been incubated with 125I-IFN gamma. polyacrylamide 217-231 interferon gamma Homo sapiens 24-33 3937225-3 1985 On day 4, after addition of 400 mu/ml IFN-gamma the [3H]thymidine uptake in these cells was reduced to 60% and 45% respectively, while no effect of IFN-gamma was evident on the proliferation of the more mature B-cell lines Raji, Ramos, B85, and Daudi. Tritium 53-55 interferon gamma Homo sapiens 38-47 3935113-3 1985 We show here that in mitogen induced peripheral blood lymphocytes, inhibition of protein synthesis using three different inhibitors (cycloheximide, puromycin, pactamycin) resulted in an increase in the steady-state levels of IFN-gamma mRNA. Cycloheximide 133-146 interferon gamma Homo sapiens 225-234 3935113-3 1985 We show here that in mitogen induced peripheral blood lymphocytes, inhibition of protein synthesis using three different inhibitors (cycloheximide, puromycin, pactamycin) resulted in an increase in the steady-state levels of IFN-gamma mRNA. Puromycin 148-157 interferon gamma Homo sapiens 225-234 3939107-0 1985 Histamine modulates the production of interferon-gamma and interleukin-2 by mitogen-activated human mononuclear blood cells. Histamine 0-9 interferon gamma Homo sapiens 38-54 3939107-1 1985 Histamine inhibited the production of interferon-gamma and interleukin 2 (IL-2) induced in human peripheral blood mononuclear cells by Staphylococcal Enterotoxin A (SEA) but had no effect on the expression of IL-2 receptors. Histamine 0-9 interferon gamma Homo sapiens 38-54 3932579-6 1985 A combination of NK-CIA and IFN-gamma suppresses late CFU-GM, at concentrations of the two lymphokines that are completely ineffective when used independently. cfu-gm 54-60 interferon gamma Homo sapiens 28-37 3933502-0 1985 Synthesis and interferon-gamma controlled release of pteridines during activation of human peripheral blood mononuclear cells. Pteridines 53-63 interferon gamma Homo sapiens 14-30 3933502-4 1985 The release of both cellular neopterin and biopterin, but not of 6-hydroxymethylpterin and its aldehyde, is controlled by interferon-gamma. Neopterin 29-38 interferon gamma Homo sapiens 122-138 3933502-4 1985 The release of both cellular neopterin and biopterin, but not of 6-hydroxymethylpterin and its aldehyde, is controlled by interferon-gamma. Biopterin 43-52 interferon gamma Homo sapiens 122-138 3935113-3 1985 We show here that in mitogen induced peripheral blood lymphocytes, inhibition of protein synthesis using three different inhibitors (cycloheximide, puromycin, pactamycin) resulted in an increase in the steady-state levels of IFN-gamma mRNA. Pactamycin 159-169 interferon gamma Homo sapiens 225-234 3933985-4 1985 Synergistic induction of IFN-gamma by mitogen plus the phorbol ester mezerein was at least in part accounted for by increased levels of IFN-gamma mRNA in both fresh lymphocytes and growing lymphoblasts. phorbol ester mezerein 55-77 interferon gamma Homo sapiens 25-34 3933985-4 1985 Synergistic induction of IFN-gamma by mitogen plus the phorbol ester mezerein was at least in part accounted for by increased levels of IFN-gamma mRNA in both fresh lymphocytes and growing lymphoblasts. phorbol ester mezerein 55-77 interferon gamma Homo sapiens 136-145 3937225-3 1985 On day 4, after addition of 400 mu/ml IFN-gamma the [3H]thymidine uptake in these cells was reduced to 60% and 45% respectively, while no effect of IFN-gamma was evident on the proliferation of the more mature B-cell lines Raji, Ramos, B85, and Daudi. Thymidine 56-65 interferon gamma Homo sapiens 38-47 2992810-1 1985 Depletion of macrophages from human peripheral blood mononuclear cells (PBMC) caused a marked decrease in galactose oxidase and sodium periodate, but not a calcium ionophore, stimulated Interferon-gamma (IFN-gamma) production. metaperiodate 128-144 interferon gamma Homo sapiens 186-202 3928752-0 1985 The synergistic influence of human interferon-gamma and interferon-alpha on suppression of hematopoietic progenitor cells is additive with the enhanced sensitivity of these cells to inhibition by interferons at low oxygen tension in vitro. Oxygen 215-221 interferon gamma Homo sapiens 35-51 3928752-7 1985 Cells grown at 5% O2 were more sensitive to inhibition by 2 log units less IFN-gamma or IFN-alpha, and this effect was additive with the synergistic effects of IFN-gamma and IFN-alpha together. Oxygen 18-20 interferon gamma Homo sapiens 75-84 3928752-7 1985 Cells grown at 5% O2 were more sensitive to inhibition by 2 log units less IFN-gamma or IFN-alpha, and this effect was additive with the synergistic effects of IFN-gamma and IFN-alpha together. Oxygen 18-20 interferon gamma Homo sapiens 160-169 3928753-0 1985 Recombinant interferon-gamma inhibits the B cell proliferative response stimulated by soluble but not by Sepharose-bound anti-immunoglobulin antibody. Sepharose 105-114 interferon gamma Homo sapiens 12-28 3938026-1 1985 Phytohemagglutinin (PHA), picibanil (OK432) and tumor promoting agent (TPA) were tested in various combinations for optimal induction of human interferon-gamma (HuIFN-gamma). Tetradecanoylphorbol Acetate 71-74 interferon gamma Homo sapiens 143-159 3935348-1 1985 The effect of phytohaemagglutinin (PHA) and/or phorbol myristic acetate (PMA) on human interferon-gamma (HuIFN-gamma) and interleukin 2 (IL-2) production was measured in peripheral blood leucocytes (PBL) from multiple sclerosis (MS) patients. Tetradecanoylphorbol Acetate 73-76 interferon gamma Homo sapiens 87-103 3160456-2 1985 A direct antiproliferative activity of IFN-gamma was observed in five of seven cell lines tested, with a reduction of [3H]thymidine incorporation between 30 and 90%. Tritium 119-121 interferon gamma Homo sapiens 39-48 3926889-8 1985 Treatment of cells with subinducing doses of Con A or phorbol myristate acetate increased IFN-gamma induction by exogenous IL 2. Tetradecanoylphorbol Acetate 54-79 interferon gamma Homo sapiens 90-99 2411582-1 1985 The monoblastlike leukemia cell line, U-937, is induced to differentiate into monocytelike cells by incubation with 200-500 U/ml of recombinant human immune interferon (IFN-gamma) judging from capacity to reduce nitroblue tetrazolium. Nitroblue Tetrazolium 212-233 interferon gamma Homo sapiens 150-178 2992637-3 1985 By contrast, after stimulation with phytohemagglutinin (PHA) or with PHA plus 12-O-tetradecanoylphorbol-13-acetate, the production of IL 2 and IFN-gamma by B-CLL T lymphocytes was similar to that of normal T lymphocytes, irrespective of the reversed T lymphocyte subset distribution (OKT4/OKT8 ratio) observed in B-CLL. Tetradecanoylphorbol Acetate 78-114 interferon gamma Homo sapiens 143-152 3924998-5 1985 Utilizing selective and partially selective pharmacologic inhibitors of arachidonic acid metabolism, the data suggest that the participation of lipoxygenase activity is required for both IL 1 induction of IL 2 production and IL 2 regulation of proliferation and IFN-gamma secretion. Arachidonic Acid 72-88 interferon gamma Homo sapiens 262-271 3925000-10 1985 The increased expression of HLA class II antigen was truly due to induction in individual TEC, rather than selection of class II-positive cells, because induction under the influence of IFN-gamma was reversible and occurred in the absence of proliferation in mitomycin-treated or gamma-irradiated cultures. Mitomycin 259-268 interferon gamma Homo sapiens 186-195 2411582-2 1985 At least an additive differentiation-inducing effect was found between IFN-gamma and 1-100 nM retinoic acid (RA). Tretinoin 94-107 interferon gamma Homo sapiens 71-86 2411582-2 1985 At least an additive differentiation-inducing effect was found between IFN-gamma and 1-100 nM retinoic acid (RA). Tretinoin 109-111 interferon gamma Homo sapiens 71-86 3926955-5 1985 Recombinant human gamma interferon (IFN gamma) activated both normal and AIDS monocyte-mediated tumoricidal function only when combined with lypopolysaccharide (LPS). lypopolysaccharide 141-159 interferon gamma Homo sapiens 18-45 2989291-6 1985 Dissociation of bound [32P]IFN-gamma at 24 degrees C exhibited two distinct rates. Phosphorus-32 23-26 interferon gamma Homo sapiens 27-36 2410553-1 1985 Recombinant interferon-gamma (IFN-gamma) in contact with human embryonic fibroblasts or with a great variety of cells from different animal species was phosphorylated in the presence of [gamma-32P]ATP and magnesium ions by a protein kinase released in the culture medium. [gamma-32p]atp 186-200 interferon gamma Homo sapiens 12-28 2410553-1 1985 Recombinant interferon-gamma (IFN-gamma) in contact with human embryonic fibroblasts or with a great variety of cells from different animal species was phosphorylated in the presence of [gamma-32P]ATP and magnesium ions by a protein kinase released in the culture medium. [gamma-32p]atp 186-200 interferon gamma Homo sapiens 30-39 2410553-1 1985 Recombinant interferon-gamma (IFN-gamma) in contact with human embryonic fibroblasts or with a great variety of cells from different animal species was phosphorylated in the presence of [gamma-32P]ATP and magnesium ions by a protein kinase released in the culture medium. Magnesium 205-214 interferon gamma Homo sapiens 12-28 2410553-1 1985 Recombinant interferon-gamma (IFN-gamma) in contact with human embryonic fibroblasts or with a great variety of cells from different animal species was phosphorylated in the presence of [gamma-32P]ATP and magnesium ions by a protein kinase released in the culture medium. Magnesium 205-214 interferon gamma Homo sapiens 30-39 2410553-2 1985 Using SDS-polyacrylamide gel electrophoresis, we found that both the monomeric (17 000 to 18 000) and dimeric (34 000 to 35 000) molecular weight forms of IFN-gamma became intensely radioactive. Sodium Dodecyl Sulfate 6-9 interferon gamma Homo sapiens 155-164 2410553-2 1985 Using SDS-polyacrylamide gel electrophoresis, we found that both the monomeric (17 000 to 18 000) and dimeric (34 000 to 35 000) molecular weight forms of IFN-gamma became intensely radioactive. polyacrylamide 10-24 interferon gamma Homo sapiens 155-164 2994206-3 1985 CsA inhibited dose-dependently the EBV-induced Hu IFN-gamma response, studied at the cellular level in human blood lymphocytes. Cyclosporine 0-3 interferon gamma Homo sapiens 50-59 3923937-4 1985 Dexamethasone inhibited the expression of interleukin 2 receptors, the synthesis of interferon-gamma, and the early proliferation and protein synthesis of lectin-activated thymocytes during the first 2 days of culture. Dexamethasone 0-13 interferon gamma Homo sapiens 84-100 3923937-5 1985 The inhibitory effect of dexamethasone on the expression of interleukin 2 receptors and on the synthesis of interferon-gamma was reversed by interleukin 2, whereas its effect on proliferation and on protein synthesis during the first two days of culture was not reversed by interleukin 2. Dexamethasone 25-38 interferon gamma Homo sapiens 108-124 3921246-1 1985 The cytocidal activity of human immune interferon (IFN-gamma) in combination with the synthetic double-stranded RNA, poly(I).poly(C), was investigated in human colon carcinoma cell line HT-29. Poly C 125-132 interferon gamma Homo sapiens 32-60 3921246-2 1985 Three days of treatment with IFN-gamma (10 to 25 units/ml) resulted in 30 to 40% reduction in colony formation, whereas poly(I).poly(C) (25 to 100 micrograms/ml) reduced cell viability by 10 to 20% of control. Poly C 128-135 interferon gamma Homo sapiens 29-38 3921246-3 1985 The lethal effect of the combination of IFN-gamma and poly(I).poly(C) was synergistic wherein 70 to 90% reduction in colony formation was observed. Poly C 62-69 interferon gamma Homo sapiens 40-49 3921246-4 1985 Measurements of DNA, RNA, and protein synthesis after IFN-gamma and poly(I).poly(C) treatment showed a dose-dependent reduction in all three parameters. Poly C 76-83 interferon gamma Homo sapiens 54-63 3921246-5 1985 Recombinant IFN-gamma in combination with poly(I).poly(C) exhibited a similar effect. Poly C 50-57 interferon gamma Homo sapiens 12-21 3921610-4 1985 The Ca++ ionophore ionomycin and TPA, used in conjunction, mimicked the effect of specific alloantigen on these T cell clones, i.e., they induced the secretion of IFN-gamma in all clones and the secretion of IL 2 in the T4+ clone. Tetradecanoylphorbol Acetate 33-36 interferon gamma Homo sapiens 163-172 3921610-4 1985 The Ca++ ionophore ionomycin and TPA, used in conjunction, mimicked the effect of specific alloantigen on these T cell clones, i.e., they induced the secretion of IFN-gamma in all clones and the secretion of IL 2 in the T4+ clone. Ionomycin 19-28 interferon gamma Homo sapiens 163-172 3921233-12 1985 Lymphocyte supernatants and IFN-gamma demonstrated similar MAF activity on three effector cells: monocytes, in vitro-differentiated macrophages, and dexamethasone-differentiated macrophages. Dexamethasone 149-162 interferon gamma Homo sapiens 28-37 3923038-7 1985 At least one role for IFN gamma in the pathogenesis of sarcoidosis appeared to be related to activation of alveolar macrophages, as alveolar macrophages recovered from patients with active disease spontaneously killed [3H]uridine-labeled tumor cell targets (17.7 +/- 4.5% cytotoxicity compared with 2.8 +/- 0.9% in normals, P less than 0.02) and purified IFN gamma enhanced the ability of alveolar macrophages from sarcoidosis patients with inactive disease to kill similar targets (P less than 0.001, compared to alveolar macrophages cultured in medium alone). Tritium 219-221 interferon gamma Homo sapiens 22-31 3923038-7 1985 At least one role for IFN gamma in the pathogenesis of sarcoidosis appeared to be related to activation of alveolar macrophages, as alveolar macrophages recovered from patients with active disease spontaneously killed [3H]uridine-labeled tumor cell targets (17.7 +/- 4.5% cytotoxicity compared with 2.8 +/- 0.9% in normals, P less than 0.02) and purified IFN gamma enhanced the ability of alveolar macrophages from sarcoidosis patients with inactive disease to kill similar targets (P less than 0.001, compared to alveolar macrophages cultured in medium alone). Uridine 222-229 interferon gamma Homo sapiens 22-31 3923038-7 1985 At least one role for IFN gamma in the pathogenesis of sarcoidosis appeared to be related to activation of alveolar macrophages, as alveolar macrophages recovered from patients with active disease spontaneously killed [3H]uridine-labeled tumor cell targets (17.7 +/- 4.5% cytotoxicity compared with 2.8 +/- 0.9% in normals, P less than 0.02) and purified IFN gamma enhanced the ability of alveolar macrophages from sarcoidosis patients with inactive disease to kill similar targets (P less than 0.001, compared to alveolar macrophages cultured in medium alone). Uridine 222-229 interferon gamma Homo sapiens 355-364 3923610-5 1985 On the contrary, the calcium ionophore A23187 (considered to act as a second specific step, following oxidation of galactose residues, toward genetic derepression of IFN-gamma) induced considerable IFN-gamma production in all the three tested patients. Calcimycin 39-45 interferon gamma Homo sapiens 166-175 3920317-8 1985 By the criteria tested, the immunosuppressive effect of L-ornithine is more selective than that of cyclosporine A, which was previously found to suppress not only the activation of cytotoxic activity but also proliferative responses and the production of the lymphokines IL 2 and IFN-gamma. Ornithine 56-67 interferon gamma Homo sapiens 280-289 3920317-8 1985 By the criteria tested, the immunosuppressive effect of L-ornithine is more selective than that of cyclosporine A, which was previously found to suppress not only the activation of cytotoxic activity but also proliferative responses and the production of the lymphokines IL 2 and IFN-gamma. Cyclosporine 99-113 interferon gamma Homo sapiens 280-289 2857744-0 1985 Interferon-gamma requires serum retinoids to promote the expression of tissue transglutaminase in cultured human blood monocytes. Retinoids 32-41 interferon gamma Homo sapiens 0-16 3919096-0 1985 Induction of interferon-gamma production by human natural killer cells stimulated by hydrogen peroxide. Hydrogen Peroxide 85-102 interferon gamma Homo sapiens 13-29 3923610-5 1985 On the contrary, the calcium ionophore A23187 (considered to act as a second specific step, following oxidation of galactose residues, toward genetic derepression of IFN-gamma) induced considerable IFN-gamma production in all the three tested patients. Calcium 21-28 interferon gamma Homo sapiens 166-175 3923610-5 1985 On the contrary, the calcium ionophore A23187 (considered to act as a second specific step, following oxidation of galactose residues, toward genetic derepression of IFN-gamma) induced considerable IFN-gamma production in all the three tested patients. Calcium 21-28 interferon gamma Homo sapiens 198-207 2580528-4 1985 These results suggest that human interferon-gamma has at least two antigenic epitopes; one of the epitopes reacted with BG 1 & BG 4 while the other reacted with BG 2; BG 3 either binds to a region overlapping with the other two epitopes or reacts with both epitopes. Adenosine Monophosphate 126-129 interferon gamma Homo sapiens 33-49 2580528-4 1985 These results suggest that human interferon-gamma has at least two antigenic epitopes; one of the epitopes reacted with BG 1 & BG 4 while the other reacted with BG 2; BG 3 either binds to a region overlapping with the other two epitopes or reacts with both epitopes. O(6)-benzylguanine 120-122 interferon gamma Homo sapiens 33-49 3923610-5 1985 On the contrary, the calcium ionophore A23187 (considered to act as a second specific step, following oxidation of galactose residues, toward genetic derepression of IFN-gamma) induced considerable IFN-gamma production in all the three tested patients. Calcimycin 39-45 interferon gamma Homo sapiens 198-207 2580528-4 1985 These results suggest that human interferon-gamma has at least two antigenic epitopes; one of the epitopes reacted with BG 1 & BG 4 while the other reacted with BG 2; BG 3 either binds to a region overlapping with the other two epitopes or reacts with both epitopes. O(6)-benzylguanine 131-133 interferon gamma Homo sapiens 33-49 2580528-4 1985 These results suggest that human interferon-gamma has at least two antigenic epitopes; one of the epitopes reacted with BG 1 & BG 4 while the other reacted with BG 2; BG 3 either binds to a region overlapping with the other two epitopes or reacts with both epitopes. O(6)-benzylguanine 131-133 interferon gamma Homo sapiens 33-49 3918105-5 1985 These studies demonstrate that both signals are required for the appearance of IL 2 or IFN-gamma-specific transcripts and that the appearance of IL 2 and IFN-gamma RNA is coordinate with regard to a) the signals required for their production, b) the kinetics of their appearance, and c) the inhibition of their appearance by cyclosporin A. Cyclosporine 325-338 interferon gamma Homo sapiens 154-163 3921560-0 1985 Influence of prostaglandin E2 and indomethacin on interferon-gamma production by cultured peripheral blood leukocytes of multiple sclerosis patients and healthy donors. Dinoprostone 13-29 interferon gamma Homo sapiens 50-66 3921560-0 1985 Influence of prostaglandin E2 and indomethacin on interferon-gamma production by cultured peripheral blood leukocytes of multiple sclerosis patients and healthy donors. Indomethacin 34-46 interferon gamma Homo sapiens 50-66 3921560-8 1985 We conclude that in a minor percentage of MS patient-derived PBL cultures, the deficiency in interferon-gamma (IFN-gamma) production can be (partially) overcome by treatment of the cells with indomethacin. Indomethacin 192-204 interferon gamma Homo sapiens 93-109 3921560-8 1985 We conclude that in a minor percentage of MS patient-derived PBL cultures, the deficiency in interferon-gamma (IFN-gamma) production can be (partially) overcome by treatment of the cells with indomethacin. Indomethacin 192-204 interferon gamma Homo sapiens 111-120 2981929-7 1985 Similar to oxygen-dependent mechanisms, the enhancement of oxygen-independent activity by crude lymphokines could be abolished by a monoclonal anti-IFN-gamma antibody and could be achieved by treatment with recombinant IFN-gamma alone. Oxygen 11-17 interferon gamma Homo sapiens 148-157 2981929-7 1985 Similar to oxygen-dependent mechanisms, the enhancement of oxygen-independent activity by crude lymphokines could be abolished by a monoclonal anti-IFN-gamma antibody and could be achieved by treatment with recombinant IFN-gamma alone. Oxygen 11-17 interferon gamma Homo sapiens 219-228 2981929-7 1985 Similar to oxygen-dependent mechanisms, the enhancement of oxygen-independent activity by crude lymphokines could be abolished by a monoclonal anti-IFN-gamma antibody and could be achieved by treatment with recombinant IFN-gamma alone. Oxygen 59-65 interferon gamma Homo sapiens 148-157 2981929-7 1985 Similar to oxygen-dependent mechanisms, the enhancement of oxygen-independent activity by crude lymphokines could be abolished by a monoclonal anti-IFN-gamma antibody and could be achieved by treatment with recombinant IFN-gamma alone. Oxygen 59-65 interferon gamma Homo sapiens 219-228 3920961-0 1985 Effects of treatment with azathioprine and cyclosporin A on interferon-gamma production by peripheral blood leukocytes of renal allograft recipients. Azathioprine 26-38 interferon gamma Homo sapiens 60-76 3918946-4 1985 All cell lines examined, except AlAb, could be induced to cell-surface expression of HLA class-II antigen after 48 hr incubation in the presence of IFN-gamma (10 units/ml). alab 32-36 interferon gamma Homo sapiens 148-157 3920961-0 1985 Effects of treatment with azathioprine and cyclosporin A on interferon-gamma production by peripheral blood leukocytes of renal allograft recipients. Cyclosporine 43-56 interferon gamma Homo sapiens 60-76 3920961-2 1985 Both under immunosuppressive treatment with azathioprine and with cyclosporin A (CsA) the PBMC of these patients proved deficient for IFN-gamma production when compared to those of healthy controls. Azathioprine 44-56 interferon gamma Homo sapiens 134-143 3920961-2 1985 Both under immunosuppressive treatment with azathioprine and with cyclosporin A (CsA) the PBMC of these patients proved deficient for IFN-gamma production when compared to those of healthy controls. Cyclosporine 66-79 interferon gamma Homo sapiens 134-143 3920961-2 1985 Both under immunosuppressive treatment with azathioprine and with cyclosporin A (CsA) the PBMC of these patients proved deficient for IFN-gamma production when compared to those of healthy controls. Cyclosporine 81-84 interferon gamma Homo sapiens 134-143 3920961-3 1985 After conversion from conventional azathioprine to CsA medication the ConA-induced IFN-gamma production increased. Azathioprine 35-47 interferon gamma Homo sapiens 83-92 3920961-3 1985 After conversion from conventional azathioprine to CsA medication the ConA-induced IFN-gamma production increased. Cyclosporine 51-54 interferon gamma Homo sapiens 83-92 3918869-9 1985 Immunoprecipitation experiments using detergent-solubilized 125I-labeled membrane proteins of IFN-gamma-treated melanoma cells and a monoclonal anti-HLA-DR antibody confirmed the presence of HLA-DR antigens. Iodine-125 60-64 interferon gamma Homo sapiens 94-103 3155725-1 1985 Recombinant human interferon gamma (rIFN-gamma) produced in Escherichia coli was labeled with 125I to study its binding to receptors of HeLa and lymphoblastoid cells. Iodine-125 94-98 interferon gamma Homo sapiens 18-46 3155725-10 1985 The turnover of the rIFN-gamma receptor was measured by inhibiting protein synthesis with cycloheximide and the half-life of this receptor was found to be 2 h. The unglycosylated rIFN-gamma was bound to cellular receptors with an affinity similar to that previously reported for natural IFN-gamma. Cycloheximide 90-103 interferon gamma Homo sapiens 21-30 2981638-0 1985 Selective inhibitory effect of Hu-IFN-gamma on the agarose clonability of tumor-derived lymphoid cell lines. Sepharose 51-58 interferon gamma Homo sapiens 34-43 2580063-5 1985 The transferred activity had the characteristics of an IFN-induced antiviral state, in that it was blocked either by actinomycin D or by prevention of cell contact. Dactinomycin 117-130 interferon gamma Homo sapiens 55-58 2981161-10 1985 Peroxide production after stimulation with phorbol myristic acid could be induced by LK, LK with anti-IFN-gamma antibody, 5637, and SK-HEP treatment. Peroxides 0-8 interferon gamma Homo sapiens 102-111 2981161-10 1985 Peroxide production after stimulation with phorbol myristic acid could be induced by LK, LK with anti-IFN-gamma antibody, 5637, and SK-HEP treatment. phorbol-12-myristate 43-64 interferon gamma Homo sapiens 102-111 2981161-12 1985 Peroxide production was induced by IFN-gamma at concentrations above 1000 units/ml. Peroxides 0-8 interferon gamma Homo sapiens 35-44 2981638-5 1985 In contrast, IFN-gamma had no effect on the growth in suspension but it abolished the clonogenic potential of tumor cell lines in semisolid agarose. Sepharose 140-147 interferon gamma Homo sapiens 13-22 2578172-5 1985 IFN-gamma induction of LC HLA-DR expression is inhibited by prostaglandin E2 (PGE2) and is mimicked by the presence of fatty acid cyclooxygenase inhibitors, known to reduce PGE2 production. Dinoprostone 60-76 interferon gamma Homo sapiens 0-9 2860101-2 1985 Recombinant plasmids containing human interferon-gamma (HuIFN-gamma) cDNAs were identified by the oligonucleotide-hybridization method. Oligonucleotides 98-113 interferon gamma Homo sapiens 38-54 2981090-7 1985 In contrast, sensitivity to the suppressive effects of PGE2 on IFN-gamma secretion was much higher with CBL than with control leukocytes. Dinoprostone 55-59 interferon gamma Homo sapiens 63-72 2981090-8 1985 Treatment with indomethacin reversed the IFN-gamma defect with most CBL tested, and the addition of physiologic amounts of PGE2 to indomethacin-treated cultures resulted in a profound impairment of IFN-gamma production similar to that of untreated CBL cultures. Indomethacin 15-27 interferon gamma Homo sapiens 41-50 3928486-6 1985 Experiments with cyclosporin A suggest that lymphocytes contaminating the monocyte preparations can produce spontaneously sufficient amounts of IFN-gamma for maintenance of the DR antigens on monocytes. Cyclosporine 17-30 interferon gamma Homo sapiens 144-153 2985717-0 1985 Induction of human interferon gamma in nylon-column nonadherent human lymphocyte cells by heat-treated poly I:poly C. Poly I 103-109 interferon gamma Homo sapiens 19-35 2985717-0 1985 Induction of human interferon gamma in nylon-column nonadherent human lymphocyte cells by heat-treated poly I:poly C. Poly C 110-116 interferon gamma Homo sapiens 19-35 3917274-4 1985 CBL produced large amounts of IFN-gamma (comparable to those observed in adult control and in mothers) after stimulation with staphylococcal enterotoxin A (SEA). Vitamin B 12 0-3 interferon gamma Homo sapiens 30-39 3917277-6 1985 However, MIF activity in supernatant fluid from human peripheral blood lymphocyte cultures stimulated with Con A-Sepharose was completely neutralized with MoAb anti-IFN-gamma. Sepharose 113-122 interferon gamma Homo sapiens 165-174 2578172-5 1985 IFN-gamma induction of LC HLA-DR expression is inhibited by prostaglandin E2 (PGE2) and is mimicked by the presence of fatty acid cyclooxygenase inhibitors, known to reduce PGE2 production. Dinoprostone 78-82 interferon gamma Homo sapiens 0-9 2981090-8 1985 Treatment with indomethacin reversed the IFN-gamma defect with most CBL tested, and the addition of physiologic amounts of PGE2 to indomethacin-treated cultures resulted in a profound impairment of IFN-gamma production similar to that of untreated CBL cultures. Dinoprostone 123-127 interferon gamma Homo sapiens 198-207 2578172-5 1985 IFN-gamma induction of LC HLA-DR expression is inhibited by prostaglandin E2 (PGE2) and is mimicked by the presence of fatty acid cyclooxygenase inhibitors, known to reduce PGE2 production. Dinoprostone 173-177 interferon gamma Homo sapiens 0-9 2981090-8 1985 Treatment with indomethacin reversed the IFN-gamma defect with most CBL tested, and the addition of physiologic amounts of PGE2 to indomethacin-treated cultures resulted in a profound impairment of IFN-gamma production similar to that of untreated CBL cultures. Indomethacin 131-143 interferon gamma Homo sapiens 198-207 3155566-1 1985 Mitogenic induction of interferon-gamma in human peripheral blood mononuclear cells (PBMC) is prevented by enzymatic cleavage of galactose residues on the cell membrane, and by calcium depletion, suggesting that oxidation of galactose on the membrane glycoproteins and activation of a calcium flux across the membrane are critical events for interferon-gamma induction in nonspecifically stimulated human PBMC. Galactose 129-138 interferon gamma Homo sapiens 23-39 2981090-9 1985 Preincubation of CBL for 24 hr before PHA stimulation resulted in restoration of a normal sensitivity to exogenous PGE2, in parallel with correction of the IFN-gamma defect. Vitamin B 12 17-20 interferon gamma Homo sapiens 156-165 2981090-10 1985 Our observations suggest that the impairment of IFN-gamma secretion in neonates is not due to deficient amplification circuits, but is the consequence of an exaggerated cellular sensitivity to the suppressive effects of PGE produced endogenously in normal amounts. Prostaglandins E 220-223 interferon gamma Homo sapiens 48-57 2419713-4 1985 At least additive effect was evident when the cells were exposed to combination of interferons and toremifene: the combination was additive with interferon gamma + toremifene and synergistic with interferon alpha + toremifene. Toremifene 99-109 interferon gamma Homo sapiens 145-161 3155566-1 1985 Mitogenic induction of interferon-gamma in human peripheral blood mononuclear cells (PBMC) is prevented by enzymatic cleavage of galactose residues on the cell membrane, and by calcium depletion, suggesting that oxidation of galactose on the membrane glycoproteins and activation of a calcium flux across the membrane are critical events for interferon-gamma induction in nonspecifically stimulated human PBMC. Calcium 177-184 interferon gamma Homo sapiens 23-39 3155566-1 1985 Mitogenic induction of interferon-gamma in human peripheral blood mononuclear cells (PBMC) is prevented by enzymatic cleavage of galactose residues on the cell membrane, and by calcium depletion, suggesting that oxidation of galactose on the membrane glycoproteins and activation of a calcium flux across the membrane are critical events for interferon-gamma induction in nonspecifically stimulated human PBMC. Galactose 225-234 interferon gamma Homo sapiens 23-39 3155566-1 1985 Mitogenic induction of interferon-gamma in human peripheral blood mononuclear cells (PBMC) is prevented by enzymatic cleavage of galactose residues on the cell membrane, and by calcium depletion, suggesting that oxidation of galactose on the membrane glycoproteins and activation of a calcium flux across the membrane are critical events for interferon-gamma induction in nonspecifically stimulated human PBMC. Galactose 225-234 interferon gamma Homo sapiens 342-358 3155566-1 1985 Mitogenic induction of interferon-gamma in human peripheral blood mononuclear cells (PBMC) is prevented by enzymatic cleavage of galactose residues on the cell membrane, and by calcium depletion, suggesting that oxidation of galactose on the membrane glycoproteins and activation of a calcium flux across the membrane are critical events for interferon-gamma induction in nonspecifically stimulated human PBMC. Calcium 285-292 interferon gamma Homo sapiens 23-39 3155566-3 1985 The results of these experiments show that also antigenic induction of interferon-gamma by purified protein derivative, tetanus toxoid, and MLR requires integrity of galactose residues and calcium intake suggesting that alteration of membrane-bound galactose and activation of a calcium flow are critical triggering events for both specific and nonspecific lymphocyte activation. Galactose 166-175 interferon gamma Homo sapiens 71-87 3155566-3 1985 The results of these experiments show that also antigenic induction of interferon-gamma by purified protein derivative, tetanus toxoid, and MLR requires integrity of galactose residues and calcium intake suggesting that alteration of membrane-bound galactose and activation of a calcium flow are critical triggering events for both specific and nonspecific lymphocyte activation. Calcium 189-196 interferon gamma Homo sapiens 71-87 3155566-3 1985 The results of these experiments show that also antigenic induction of interferon-gamma by purified protein derivative, tetanus toxoid, and MLR requires integrity of galactose residues and calcium intake suggesting that alteration of membrane-bound galactose and activation of a calcium flow are critical triggering events for both specific and nonspecific lymphocyte activation. Galactose 249-258 interferon gamma Homo sapiens 71-87 3155566-3 1985 The results of these experiments show that also antigenic induction of interferon-gamma by purified protein derivative, tetanus toxoid, and MLR requires integrity of galactose residues and calcium intake suggesting that alteration of membrane-bound galactose and activation of a calcium flow are critical triggering events for both specific and nonspecific lymphocyte activation. Calcium 279-286 interferon gamma Homo sapiens 71-87 6094340-2 1984 The amount of IFN gamma produced was enhanced in the presence of mezerein, a phorbol ester derivative. mezerein 65-73 interferon gamma Homo sapiens 14-23 6435860-5 1984 Hydrocortisone was found to eliminate IFN-gamma production if added within 24 hr after the phytohemagglutinin. Hydrocortisone 0-14 interferon gamma Homo sapiens 38-47 6435860-6 1984 The suppression of IFN-gamma production occurred with hydrocortisone concentrations as low as 0.65 microgram/ml, was associated with a diminished proliferative response to the lectin, and occurred with other interferon inducers including staphylococcal enterotoxin A. Hydrocortisone 54-68 interferon gamma Homo sapiens 19-28 6435860-7 1984 Adriamycin (0.4 microgram/ml) and vincristine (0.08 microgram/ml) also diminished IFN-gamma production, but only if the peripheral blood mononuclear cells were pretreated with the drugs. Doxorubicin 0-10 interferon gamma Homo sapiens 82-91 6435860-7 1984 Adriamycin (0.4 microgram/ml) and vincristine (0.08 microgram/ml) also diminished IFN-gamma production, but only if the peripheral blood mononuclear cells were pretreated with the drugs. Vincristine 34-45 interferon gamma Homo sapiens 82-91 6094340-2 1984 The amount of IFN gamma produced was enhanced in the presence of mezerein, a phorbol ester derivative. Phorbol Esters 77-90 interferon gamma Homo sapiens 14-23 6094340-4 1984 The spontaneous production of IFN gamma by T-cell hybridomas was not influenced by the presence of jacalin, although significant enhancement of production was observed when the cells were cultured in the presence of mezerein. mezerein 216-224 interferon gamma Homo sapiens 30-39 6436183-0 1984 Cytolytic activity of interferon-gamma and its synergism with 5-fluorouracil. Fluorouracil 62-76 interferon gamma Homo sapiens 22-38 6436183-4 1984 A synergistic cytolysis on HT-29 cells of IFN-gamma and 5-fluorouracil (5-FU) was observed at 5-FU concentrations ranging from 64 to 640 micrograms/ml. Fluorouracil 72-76 interferon gamma Homo sapiens 42-51 6436183-4 1984 A synergistic cytolysis on HT-29 cells of IFN-gamma and 5-fluorouracil (5-FU) was observed at 5-FU concentrations ranging from 64 to 640 micrograms/ml. Fluorouracil 94-98 interferon gamma Homo sapiens 42-51 6436183-6 1984 The direct cytolytic activity and synergistic cytolysis with 5-FU of the IFN-gamma preparations used in the present study were abolished completely by treatment with a neutralizing monoclonal antibody specific for human IFN-gamma. Fluorouracil 61-65 interferon gamma Homo sapiens 73-82 6436183-6 1984 The direct cytolytic activity and synergistic cytolysis with 5-FU of the IFN-gamma preparations used in the present study were abolished completely by treatment with a neutralizing monoclonal antibody specific for human IFN-gamma. Fluorouracil 61-65 interferon gamma Homo sapiens 220-229 6437395-6 1984 After treatment of LCM with monoclonal antibody to IFN-gamma, LCM activity was reduced more than 50% in ML-1 cells, and 80% in HL-60 cells. Lincomycin 19-22 interferon gamma Homo sapiens 51-60 6431409-8 1984 Populations of monocytes incubated 3 days with 100 units of IFN-gamma per ml (0.5 nM) had enhanced capacity to produce H2O2 in response to phorbol 12-myristate 13-acetate and increased content of acid phosphatase and plasminogen activator. Hydrogen Peroxide 119-123 interferon gamma Homo sapiens 60-69 6088628-7 1984 IFN-alpha and IFN-beta had only slight effects on the expression of Fc epsilon R. Dexamethasone (200 nM) diminished the IFN-gamma-induced enhancement in the number of Fc epsilon R by about 50%, the same extent as in control cells. Dexamethasone 82-95 interferon gamma Homo sapiens 120-129 6088631-6 1984 Glucocorticoids (hydrocortisone, corticosterone, dexamethasone, prednisolone, and fludrocortisone) antagonized the induction of Ia antigens by IFN-gamma, whereas sex steroids (progesterone, estradiol, and testosterone) and a mineralocorticoid (aldosterone) did not. Hydrocortisone 17-31 interferon gamma Homo sapiens 143-152 6088631-6 1984 Glucocorticoids (hydrocortisone, corticosterone, dexamethasone, prednisolone, and fludrocortisone) antagonized the induction of Ia antigens by IFN-gamma, whereas sex steroids (progesterone, estradiol, and testosterone) and a mineralocorticoid (aldosterone) did not. Corticosterone 33-47 interferon gamma Homo sapiens 143-152 6088631-6 1984 Glucocorticoids (hydrocortisone, corticosterone, dexamethasone, prednisolone, and fludrocortisone) antagonized the induction of Ia antigens by IFN-gamma, whereas sex steroids (progesterone, estradiol, and testosterone) and a mineralocorticoid (aldosterone) did not. Dexamethasone 49-62 interferon gamma Homo sapiens 143-152 6088631-6 1984 Glucocorticoids (hydrocortisone, corticosterone, dexamethasone, prednisolone, and fludrocortisone) antagonized the induction of Ia antigens by IFN-gamma, whereas sex steroids (progesterone, estradiol, and testosterone) and a mineralocorticoid (aldosterone) did not. Prednisolone 64-76 interferon gamma Homo sapiens 143-152 6088631-6 1984 Glucocorticoids (hydrocortisone, corticosterone, dexamethasone, prednisolone, and fludrocortisone) antagonized the induction of Ia antigens by IFN-gamma, whereas sex steroids (progesterone, estradiol, and testosterone) and a mineralocorticoid (aldosterone) did not. Fludrocortisone 82-97 interferon gamma Homo sapiens 143-152 6088631-6 1984 Glucocorticoids (hydrocortisone, corticosterone, dexamethasone, prednisolone, and fludrocortisone) antagonized the induction of Ia antigens by IFN-gamma, whereas sex steroids (progesterone, estradiol, and testosterone) and a mineralocorticoid (aldosterone) did not. Progesterone 176-188 interferon gamma Homo sapiens 143-152 6088631-6 1984 Glucocorticoids (hydrocortisone, corticosterone, dexamethasone, prednisolone, and fludrocortisone) antagonized the induction of Ia antigens by IFN-gamma, whereas sex steroids (progesterone, estradiol, and testosterone) and a mineralocorticoid (aldosterone) did not. Estradiol 190-199 interferon gamma Homo sapiens 143-152 6088631-6 1984 Glucocorticoids (hydrocortisone, corticosterone, dexamethasone, prednisolone, and fludrocortisone) antagonized the induction of Ia antigens by IFN-gamma, whereas sex steroids (progesterone, estradiol, and testosterone) and a mineralocorticoid (aldosterone) did not. Testosterone 205-217 interferon gamma Homo sapiens 143-152 6088631-6 1984 Glucocorticoids (hydrocortisone, corticosterone, dexamethasone, prednisolone, and fludrocortisone) antagonized the induction of Ia antigens by IFN-gamma, whereas sex steroids (progesterone, estradiol, and testosterone) and a mineralocorticoid (aldosterone) did not. Aldosterone 244-255 interferon gamma Homo sapiens 143-152 6088631-8 1984 In contrast to their effectiveness on macrophages, prostaglandin E2 and dibutyryl cyclic AMP only slightly inhibited the induction of Ia antigens on TDMC by IFN-gamma, whereas endotoxin (1 to 60 micrograms/ml) had no effect. Dinoprostone 51-67 interferon gamma Homo sapiens 157-166 6088631-8 1984 In contrast to their effectiveness on macrophages, prostaglandin E2 and dibutyryl cyclic AMP only slightly inhibited the induction of Ia antigens on TDMC by IFN-gamma, whereas endotoxin (1 to 60 micrograms/ml) had no effect. Bucladesine 72-92 interferon gamma Homo sapiens 157-166 6088631-8 1984 In contrast to their effectiveness on macrophages, prostaglandin E2 and dibutyryl cyclic AMP only slightly inhibited the induction of Ia antigens on TDMC by IFN-gamma, whereas endotoxin (1 to 60 micrograms/ml) had no effect. tdmc 149-153 interferon gamma Homo sapiens 157-166 6432554-6 1984 The tumor promoters 12-O-tetradecanoyl phorbol-13-acetate and teleocidin largely reversed the inhibition by 9.6 of IFN-gamma production and metabolic activation induced by mitogens. Tetradecanoylphorbol Acetate 20-57 interferon gamma Homo sapiens 115-124 6432554-6 1984 The tumor promoters 12-O-tetradecanoyl phorbol-13-acetate and teleocidin largely reversed the inhibition by 9.6 of IFN-gamma production and metabolic activation induced by mitogens. teleocidins 62-72 interferon gamma Homo sapiens 115-124 6429853-3 1984 Dexamethasone, an immunosuppressant drug that inhibits IL-2 synthesis, diminished the expression of IL-2 receptors and the synthesis of IFN-gamma. Dexamethasone 0-13 interferon gamma Homo sapiens 136-145 6429853-6 1984 Anti-Tac in combination with dexamethasone also exerted a synergistic effect on IFN-gamma synthesis, inhibiting it almost completely. Dexamethasone 29-42 interferon gamma Homo sapiens 80-89 6429853-7 1984 The inhibitory effect of dexamethasone IFN-gamma synthesis may be of clinical importance, since IFN-gamma activates macrophages and thereby triggers one of the defense mechanisms against bacterial infections. Dexamethasone 25-38 interferon gamma Homo sapiens 39-48 6429853-7 1984 The inhibitory effect of dexamethasone IFN-gamma synthesis may be of clinical importance, since IFN-gamma activates macrophages and thereby triggers one of the defense mechanisms against bacterial infections. Dexamethasone 25-38 interferon gamma Homo sapiens 96-105 6330733-4 1984 By using anti-IFN-alpha and anti-IFN-gamma sera, it was shown that the high antiviral activity in GM3299 after heat shock is due to a synergistic effect of constitutively produced IFN-alpha and induced IFN-gamma. gm3299 98-104 interferon gamma Homo sapiens 33-42 6330733-4 1984 By using anti-IFN-alpha and anti-IFN-gamma sera, it was shown that the high antiviral activity in GM3299 after heat shock is due to a synergistic effect of constitutively produced IFN-alpha and induced IFN-gamma. gm3299 98-104 interferon gamma Homo sapiens 202-211 6432902-3 1984 Although gamma-interferon (IFN gamma) is produced by T cells treated with phorbol esters, IFN gamma is probably not the mediator of enhancement of natural killer cell activity, because anti-IFN gamma antibodies failed to block this enhancement. Phorbol Esters 74-88 interferon gamma Homo sapiens 27-36 6431003-2 1984 We report that the intraerythrocytic parasite P. falciparum is lethally susceptible to the imposition of oxygen-dependent and oxygen-independent factor(s) released by interferon-gamma-activated, monocyte-derived human macrophages. Oxygen 105-111 interferon gamma Homo sapiens 167-183 6431003-2 1984 We report that the intraerythrocytic parasite P. falciparum is lethally susceptible to the imposition of oxygen-dependent and oxygen-independent factor(s) released by interferon-gamma-activated, monocyte-derived human macrophages. Oxygen 126-132 interferon gamma Homo sapiens 167-183 6431409-8 1984 Populations of monocytes incubated 3 days with 100 units of IFN-gamma per ml (0.5 nM) had enhanced capacity to produce H2O2 in response to phorbol 12-myristate 13-acetate and increased content of acid phosphatase and plasminogen activator. Tetradecanoylphorbol Acetate 139-170 interferon gamma Homo sapiens 60-69 6329186-1 1984 Highly purified native and recombinant 125I-interferon-gamma was acylated with the photoreactive cross-linking reagent, N-succinimidyl-6(4"-azido-2"-nitrophenylamino) hexanoate. N-succinimidyl-6-(4'-azido-2'-nitrophenylamino)hexanoate 120-176 interferon gamma Homo sapiens 44-60 6426803-4 1984 IFN-gamma production induced by phytohemagglutinin (PHA) in both fresh peripheral blood mononuclear leukocytes ( PBML ) and T-lymphocyte lines was augmented by 5- to 10-fold when cultured with SRBCs. srbcs 193-198 interferon gamma Homo sapiens 0-9 6426803-6 1984 The augmenting effect of SRBCs was independent of blastogenic events since DNA synthesis was not similarly augmented by SRBCs and because IFN-gamma production was only increased after blastogenesis had occurred (in already differentiated lymphoblasts or in PBML 2-3 days after induction). srbcs 25-30 interferon gamma Homo sapiens 138-147 6423641-1 1984 Immune interferon (IFN-gamma), endogenously labeled with [35S]methionine, was produced in human peripheral blood lymphocyte cultures stimulated with 12-O-tetradecanoylphorbol-13-acetate and phytohemagglutinin. Sulfur-35 58-61 interferon gamma Homo sapiens 0-28 6425412-5 1984 When a highly purified preparation of 125I-labeled natural IFN-gamma was loaded onto the affinity column, all of the biological activity was retained on the column. Iodine-125 38-42 interferon gamma Homo sapiens 59-68 6425412-6 1984 The bulk of 125I-labeled IFN-gamma bound to the affinity column be eluted in biologically active form, suggesting that antibody B1 could be used for the purification of human IFN-gamma. Iodine-125 12-16 interferon gamma Homo sapiens 25-34 6425412-6 1984 The bulk of 125I-labeled IFN-gamma bound to the affinity column be eluted in biologically active form, suggesting that antibody B1 could be used for the purification of human IFN-gamma. Iodine-125 12-16 interferon gamma Homo sapiens 175-184 6423641-1 1984 Immune interferon (IFN-gamma), endogenously labeled with [35S]methionine, was produced in human peripheral blood lymphocyte cultures stimulated with 12-O-tetradecanoylphorbol-13-acetate and phytohemagglutinin. Methionine 62-72 interferon gamma Homo sapiens 0-28 6425412-7 1984 Analysis of IFN-gamma eluted from the column by NaDodSO4/polyacrylamide gel electrophoresis (SDS-PAGE) indicated that both of the known molecular weight subspecies of IFN-gamma (25,000 and 20,000 MW), as well as the presumed dimer of 45,000 MW, were retained by the B1 antibody affinity column. nadodso4 48-56 interferon gamma Homo sapiens 12-21 6425412-7 1984 Analysis of IFN-gamma eluted from the column by NaDodSO4/polyacrylamide gel electrophoresis (SDS-PAGE) indicated that both of the known molecular weight subspecies of IFN-gamma (25,000 and 20,000 MW), as well as the presumed dimer of 45,000 MW, were retained by the B1 antibody affinity column. nadodso4 48-56 interferon gamma Homo sapiens 167-176 6423641-1 1984 Immune interferon (IFN-gamma), endogenously labeled with [35S]methionine, was produced in human peripheral blood lymphocyte cultures stimulated with 12-O-tetradecanoylphorbol-13-acetate and phytohemagglutinin. Tetradecanoylphorbol Acetate 149-185 interferon gamma Homo sapiens 0-28 6425412-7 1984 Analysis of IFN-gamma eluted from the column by NaDodSO4/polyacrylamide gel electrophoresis (SDS-PAGE) indicated that both of the known molecular weight subspecies of IFN-gamma (25,000 and 20,000 MW), as well as the presumed dimer of 45,000 MW, were retained by the B1 antibody affinity column. polyacrylamide 57-71 interferon gamma Homo sapiens 12-21 6425412-7 1984 Analysis of IFN-gamma eluted from the column by NaDodSO4/polyacrylamide gel electrophoresis (SDS-PAGE) indicated that both of the known molecular weight subspecies of IFN-gamma (25,000 and 20,000 MW), as well as the presumed dimer of 45,000 MW, were retained by the B1 antibody affinity column. polyacrylamide 57-71 interferon gamma Homo sapiens 167-176 6423641-2 1984 35S-IFN-gamma, immunoprecipitated from the crude culture fluid with a monoclonal antibody, was resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis into three monomeric forms with molecular weights of 25,000, 20,000, and 15,500, which we designate IFN-gamma I, II, and III, respectively. Sodium Dodecyl Sulfate 107-129 interferon gamma Homo sapiens 4-13 6425412-7 1984 Analysis of IFN-gamma eluted from the column by NaDodSO4/polyacrylamide gel electrophoresis (SDS-PAGE) indicated that both of the known molecular weight subspecies of IFN-gamma (25,000 and 20,000 MW), as well as the presumed dimer of 45,000 MW, were retained by the B1 antibody affinity column. Sodium Dodecyl Sulfate 93-96 interferon gamma Homo sapiens 12-21 6423641-2 1984 35S-IFN-gamma, immunoprecipitated from the crude culture fluid with a monoclonal antibody, was resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis into three monomeric forms with molecular weights of 25,000, 20,000, and 15,500, which we designate IFN-gamma I, II, and III, respectively. polyacrylamide 130-144 interferon gamma Homo sapiens 4-13 6425412-7 1984 Analysis of IFN-gamma eluted from the column by NaDodSO4/polyacrylamide gel electrophoresis (SDS-PAGE) indicated that both of the known molecular weight subspecies of IFN-gamma (25,000 and 20,000 MW), as well as the presumed dimer of 45,000 MW, were retained by the B1 antibody affinity column. Sodium Dodecyl Sulfate 93-96 interferon gamma Homo sapiens 167-176 6423641-4 1984 Changes in the molecular size of the monomeric forms after glycosidase treatment suggested that IFN-gamma I contains more carbohydrate than IFN-gamma II, and that IFN-gamma III may not be glycosylated at all. Carbohydrates 122-134 interferon gamma Homo sapiens 96-105 6423641-5 1984 Hence, the differences in the carbohydrate contents are likely to be the major cause of the molecular size heterogeneity of IFN-gamma I, II, and III. Carbohydrates 30-42 interferon gamma Homo sapiens 124-133 6420462-2 1984 Interferon-gamma increases HLA-DR expression and inhibits phagocytosis of zymosan. Zymosan 74-81 interferon gamma Homo sapiens 0-16 6234201-1 1984 Several recombinant plasmids have been constructed which direct high-level synthesis of mature human interferon gamma (IFN-gamma) in Escherichia coli using the inducible leftward promoter pL of phage lambda followed by a translational initiator region derived either from the phage MS2 replicase gene or the E. coli tryptophan attenuator region. Tryptophan 316-326 interferon gamma Homo sapiens 101-128 6420464-4 1984 The effect of IFN-gamma on Ii synthesis in P cells was not due merely to inhibition of proliferation, as is the case with certain B cell lines, because treatment of P cells with mitomycin C did not induce the invariant chain. Mitomycin 178-189 interferon gamma Homo sapiens 14-23 6424936-7 1984 Accompanying 1-day treatment with IFN-gamma (100 units/ml) was an induction of a polyamine-dependent protein kinase, which was double-stranded RNA-independent and phosphorylated endogenous polypeptides with molecular weights of 68,000 and 72,000. Polyamines 81-90 interferon gamma Homo sapiens 34-43 6424936-9 1984 These data suggest that IFN-gamma-dependent toxicity is not related to (2",5")oligo(A) activation of a latent endoribonuclease but is accompanied by protein phosphorylation, which is, in part, stimulated by exogenous polyamines. (2",5")oligo 71-83 interferon gamma Homo sapiens 24-33 6424936-9 1984 These data suggest that IFN-gamma-dependent toxicity is not related to (2",5")oligo(A) activation of a latent endoribonuclease but is accompanied by protein phosphorylation, which is, in part, stimulated by exogenous polyamines. Polyamines 217-227 interferon gamma Homo sapiens 24-33 6326118-3 1984 Analysis of total cell lysates on NaDodSO4/polyacrylamide gels revealed a 17,200-dalton protein, expected for the nonglycosylated form of human interferon-gamma, that constitutes greater than 15% of total cell protein. nadodso4 34-42 interferon gamma Homo sapiens 144-160 6326118-3 1984 Analysis of total cell lysates on NaDodSO4/polyacrylamide gels revealed a 17,200-dalton protein, expected for the nonglycosylated form of human interferon-gamma, that constitutes greater than 15% of total cell protein. polyacrylamide 43-57 interferon gamma Homo sapiens 144-160 6207796-3 1984 The affinity of Blue Dextran and its congeners to interferons were: IFN-beta greater than IFN-alpha greater than IFN-gamma. blue dextran 16-28 interferon gamma Homo sapiens 113-122 6142708-1 1984 Fresh human peripheral blood mononuclear lymphocytes and lymphoblasts that had been grown for a period in T-cell growth-factor containing medium were stimulated with staphylococcal enterotoxin A plus mezerein to produce interferon-gamma (IFN-gamma). mezerein 200-208 interferon gamma Homo sapiens 220-236 6084639-6 1984 Treatment of the immunoprecipitated IFN-gamma molecule with endoglycosylase F led to a stepwise removal of the carbohydrate portions on both the 25 and 20 kD chains, which resulted in the appearance of both 16 kD and 18 kD chains. Carbohydrates 111-123 interferon gamma Homo sapiens 36-45 6099864-8 1984 Conventional IFN-gamma inducers, concanavalin A and 12-O-tetradecanoyl-phorbol-13-acetate, further enhanced the production of IFN in this cell line. Tetradecanoylphorbol Acetate 52-89 interferon gamma Homo sapiens 13-22 6425424-4 1984 These results suggest that the heterogeneity of IFN-gamma induced in our system was the result of the difference in the content of sialic acids. Sialic Acids 131-143 interferon gamma Homo sapiens 48-57 6417232-10 1983 In comparison, Escherichia coli-derived recombinant human IFN-gamma separated by SDS-PAGE yielded two major active fractions with m.w. Sodium Dodecyl Sulfate 81-84 interferon gamma Homo sapiens 58-67 6305965-7 1983 125I-labeled IFN-gamma was resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis into two bands with molecular weights of 25,000 and 20,000. Sodium Dodecyl Sulfate 39-61 interferon gamma Homo sapiens 13-22 6415111-5 1983 In addition, partially purified and pure recombinant human IFN-gamma were as effective as crude lymphokines in activating macrophages, and 3 d of treatment with 300 U/ml resulted in a seven- to eightfold increase in H2O2 generation and the intracellular killing of both L. donovani promastigotes and amastigotes. Hydrogen Peroxide 216-220 interferon gamma Homo sapiens 59-68 6415111-7 1983 These results suggest that IFN-gamma is the key macrophage-activating molecule present within human lymphokines, and indicate that IFN-gamma can enhance both the oxygen-dependent and -independent antiprotozoal mechanisms of human mononuclear phagocytes. Oxygen 162-168 interferon gamma Homo sapiens 27-36 6415111-7 1983 These results suggest that IFN-gamma is the key macrophage-activating molecule present within human lymphokines, and indicate that IFN-gamma can enhance both the oxygen-dependent and -independent antiprotozoal mechanisms of human mononuclear phagocytes. Oxygen 162-168 interferon gamma Homo sapiens 131-140 6411853-5 1983 The capacity of macrophages to secrete H2O2 after incubation in partially purified native IFN gamma (mean peak stimulation, 8.8-fold) was greater than with unpurified lymphokines (3.8-fold) and sometimes equaled or exceeded the capacity of freshly harvested monocytes. Hydrogen Peroxide 39-43 interferon gamma Homo sapiens 90-99 6411853-8 1983 Recombinant IFN gamma had potent MAF activity, stimulating the peroxide-releasing capacity of macrophages an average of 19.8-fold at peak response and enhancing their ability to kill toxoplasmas from 2.6 +/- 1.3% for untreated cells to 54 +/- 0.4% for treated cells. Peroxides 63-71 interferon gamma Homo sapiens 12-21 6411853-9 1983 Attainment of 50% of the maximal elevation in peroxide-releasing capacity required a geometric mean concentration of 0.1 antiviral U/ml of recombinant IFN gamma, which is estimated to be approximately 6 picomolar for this preparation. Peroxides 46-54 interferon gamma Homo sapiens 151-160 6411853-10 1983 Peroxide secretory capacity and toxoplasmacidal activity of macrophages peaked 2-4 d after exposure to IFN gamma. Peroxides 0-8 interferon gamma Homo sapiens 103-112 6308636-4 1983 CHO-produced Hu IFN-gamma migrates as two bands corresponding to molecular weights of 25,000 and 21,000 on NaDodSO4/polyacrylamide gels. cho 0-3 interferon gamma Homo sapiens 16-25 6308636-4 1983 CHO-produced Hu IFN-gamma migrates as two bands corresponding to molecular weights of 25,000 and 21,000 on NaDodSO4/polyacrylamide gels. nadodso4 107-115 interferon gamma Homo sapiens 16-25 6308636-4 1983 CHO-produced Hu IFN-gamma migrates as two bands corresponding to molecular weights of 25,000 and 21,000 on NaDodSO4/polyacrylamide gels. polyacrylamide 116-130 interferon gamma Homo sapiens 16-25 6409425-1 1983 Previous studies showed that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and several structurally related tumor-promoting compounds stimulate lymphocytes to produce immune interferon (IFN-gamma) and interleukin 2 (IL-2). Phorbol Esters 49-62 interferon gamma Homo sapiens 217-226 6409425-1 1983 Previous studies showed that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and several structurally related tumor-promoting compounds stimulate lymphocytes to produce immune interferon (IFN-gamma) and interleukin 2 (IL-2). Tetradecanoylphorbol Acetate 63-99 interferon gamma Homo sapiens 217-226 6409425-1 1983 Previous studies showed that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and several structurally related tumor-promoting compounds stimulate lymphocytes to produce immune interferon (IFN-gamma) and interleukin 2 (IL-2). Tetradecanoylphorbol Acetate 101-104 interferon gamma Homo sapiens 217-226 6305965-7 1983 125I-labeled IFN-gamma was resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis into two bands with molecular weights of 25,000 and 20,000. polyacrylamide 62-76 interferon gamma Homo sapiens 13-22 6300774-5 1983 Molecular weight of hIFN-gamma produced by E. coli was estimated to be about 32,000 and 17,000 by gel filtration and SDS-polyacrylamide gel electrophoresis respectively. Sodium Dodecyl Sulfate 117-120 interferon gamma Homo sapiens 20-30 6304043-6 1983 Both sodium azide (15 mM) and methylamine (20 mM) inhibited both the uptake and degradation of IFN-gamma at all times up to 6 h. While uptake was only slightly reduced in the presence of chloroquine (25 microM), degradation was markedly inhibited, suggesting that degradation occurs intracellularly, probably within lysosomes. Sodium Azide 5-17 interferon gamma Homo sapiens 95-104 6304043-6 1983 Both sodium azide (15 mM) and methylamine (20 mM) inhibited both the uptake and degradation of IFN-gamma at all times up to 6 h. While uptake was only slightly reduced in the presence of chloroquine (25 microM), degradation was markedly inhibited, suggesting that degradation occurs intracellularly, probably within lysosomes. methylamine 30-41 interferon gamma Homo sapiens 95-104 6304043-6 1983 Both sodium azide (15 mM) and methylamine (20 mM) inhibited both the uptake and degradation of IFN-gamma at all times up to 6 h. While uptake was only slightly reduced in the presence of chloroquine (25 microM), degradation was markedly inhibited, suggesting that degradation occurs intracellularly, probably within lysosomes. Chloroquine 187-198 interferon gamma Homo sapiens 95-104 6300774-5 1983 Molecular weight of hIFN-gamma produced by E. coli was estimated to be about 32,000 and 17,000 by gel filtration and SDS-polyacrylamide gel electrophoresis respectively. polyacrylamide 121-135 interferon gamma Homo sapiens 20-30 6417283-2 1983 As previously reported, costimulation by 5 ng/ml of 12-O-tetradecanoylphorbol-13-acetate (TPA) and 5 microgram/ml of phytohemagglutinin (PHA) caused a marked enhancement of IFN-gamma levels compared to the yields obtained with PHA alone. Tetradecanoylphorbol Acetate 52-88 interferon gamma Homo sapiens 173-182 6403360-6 1983 Finally, cyclosporin A, a potent and selective immunosuppressive drug for T cells, strongly inhibited the secretion of IFN-gamma as assayed at the cell level. Cyclosporine 9-22 interferon gamma Homo sapiens 119-128 6417283-2 1983 As previously reported, costimulation by 5 ng/ml of 12-O-tetradecanoylphorbol-13-acetate (TPA) and 5 microgram/ml of phytohemagglutinin (PHA) caused a marked enhancement of IFN-gamma levels compared to the yields obtained with PHA alone. Tetradecanoylphorbol Acetate 90-93 interferon gamma Homo sapiens 173-182 6417283-4 1983 Mezerein (MZN), a compound structurally related to TPA, was found to be similar to TPA in enhancing IFN-gamma and IL-2 levels. mezerein 0-8 interferon gamma Homo sapiens 100-109 6417283-4 1983 Mezerein (MZN), a compound structurally related to TPA, was found to be similar to TPA in enhancing IFN-gamma and IL-2 levels. mezerein 10-13 interferon gamma Homo sapiens 100-109 6417283-4 1983 Mezerein (MZN), a compound structurally related to TPA, was found to be similar to TPA in enhancing IFN-gamma and IL-2 levels. Tetradecanoylphorbol Acetate 83-86 interferon gamma Homo sapiens 100-109 6417283-5 1983 In addition to TPA and MZN, four other related phorbol esters caused a stimulation of IFN-gamma and IL-2, with the production of IL-2 paralleling the production of IFN-gamma. mezerein 23-26 interferon gamma Homo sapiens 86-95 6417283-5 1983 In addition to TPA and MZN, four other related phorbol esters caused a stimulation of IFN-gamma and IL-2, with the production of IL-2 paralleling the production of IFN-gamma. Phorbol Esters 47-61 interferon gamma Homo sapiens 86-95 6417283-5 1983 In addition to TPA and MZN, four other related phorbol esters caused a stimulation of IFN-gamma and IL-2, with the production of IL-2 paralleling the production of IFN-gamma. Phorbol Esters 47-61 interferon gamma Homo sapiens 164-173 6814359-5 1982 GM2 at a concentration of 200 microM almost completely inhibited the antiviral activity of 100 units/ml of IFN-gamma, but GM1, GM3 and glycophorin had only a moderate inhibitory effect. gm2 0-3 interferon gamma Homo sapiens 107-116 6814359-1 1982 We have studied neutralization of the antiviral activity of human fibroblast (IFN-beta) and immune interferon (IFN-gamma) by incubation with glycolipids (including the gangliosides GM1, GM2 and GM3, as well as various other glycolipids) and with the sialoglycoprotein, glycophorin. Glycolipids 141-152 interferon gamma Homo sapiens 111-120 6188465-1 1983 Treatment of human peripheral blood mononuclear leukocytes with phytohaemmaglutinin and the tumour promoter teleocidin, results in the production of large amounts of interferon-gamma and significant amounts of a novel interferon-like substance which we tentatively class as interferon-delta. teleocidins 108-118 interferon gamma Homo sapiens 166-182 6181013-1 1982 Retinoic acid (RA) suppressed the production of interferon (IFN) alpha and IFN gamma of human peripheral blood leukocytes in response to stimulation with lectin mitogens, bacterial products, synthetic polynucleotides, viruses, and tumor cell lines in vitro. Tretinoin 0-13 interferon gamma Homo sapiens 75-84 6181013-1 1982 Retinoic acid (RA) suppressed the production of interferon (IFN) alpha and IFN gamma of human peripheral blood leukocytes in response to stimulation with lectin mitogens, bacterial products, synthetic polynucleotides, viruses, and tumor cell lines in vitro. Tretinoin 15-17 interferon gamma Homo sapiens 75-84 6181013-1 1982 Retinoic acid (RA) suppressed the production of interferon (IFN) alpha and IFN gamma of human peripheral blood leukocytes in response to stimulation with lectin mitogens, bacterial products, synthetic polynucleotides, viruses, and tumor cell lines in vitro. Polynucleotides 201-216 interferon gamma Homo sapiens 75-84 6814359-6 1982 These results suggest that the terminal N-acetylneuraminic acid (NANA) residues of gangliosides and of glycophorin play an important role in the inhibition of IFN-beta, and that they may be similarly involved in the inhibition of IFN-gamma. Gangliosides 83-95 interferon gamma Homo sapiens 230-239 6182256-4 1982 Formamide sucrose gradient centrifugation analysis indicated that the mRNA which codes for IFN-gamma sediments at around 15 S. The profile, however, suggested a size heterogeneity of IFN-specific mRNA. formamide 0-9 interferon gamma Homo sapiens 91-100 6177002-1 1982 Interferon (IFN)-gamma was produced in cultures of human leukocytes by combined stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and phytohemagglutinin (PHA). Tetradecanoylphorbol Acetate 97-133 interferon gamma Homo sapiens 0-22 6177002-1 1982 Interferon (IFN)-gamma was produced in cultures of human leukocytes by combined stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and phytohemagglutinin (PHA). Tetradecanoylphorbol Acetate 135-138 interferon gamma Homo sapiens 0-22 6177764-2 1982 Lymphocyte proliferation was significantly enhanced in cultures with PMA at concentrations greater than or equal to 12.5 ng/ml, and interferon-gamma production was synergistically increased in cultures with PMA at concentrations greater than or equal to 5 ng/ml. Tetradecanoylphorbol Acetate 207-210 interferon gamma Homo sapiens 132-148 6180381-4 1982 Nucleotide sequence analysis of several IFN-gamma cDNA clones showed the presence of a CGA (Arg) codon at position 140 of mature IFN-gamma in contrast with the CAA (Gln) codon, which is found in p69 (1). Arginine 92-95 interferon gamma Homo sapiens 40-49 6180381-4 1982 Nucleotide sequence analysis of several IFN-gamma cDNA clones showed the presence of a CGA (Arg) codon at position 140 of mature IFN-gamma in contrast with the CAA (Gln) codon, which is found in p69 (1). Arginine 92-95 interferon gamma Homo sapiens 129-138 6177002-2 1982 IFN-gamma was purified by sequential adsorption and elution from controlled-pore glass and concanavalin A-Sepharose and by subsequent adsorptive removal of contaminating proteins on DEAE-Sephacel at pH 8.0. deae-sephacel 182-195 interferon gamma Homo sapiens 0-9 6177002-3 1982 Treatment of such partially purified IFN-gamma preparations with the anionic detergent NaDodSO4 (0.1% at 20-25 degrees C) decreased biological activity to approximately 5-20%. nadodso4 87-95 interferon gamma Homo sapiens 37-46 6177002-7 1982 Native IFN-gamma was found to have a lower affinity for alkyl agarose columns than human IFN-alpha or IFN-beta did, suggesting that IFN-gamma is a relatively hydrophilic protein. Sepharose 62-69 interferon gamma Homo sapiens 7-16 6177002-7 1982 Native IFN-gamma was found to have a lower affinity for alkyl agarose columns than human IFN-alpha or IFN-beta did, suggesting that IFN-gamma is a relatively hydrophilic protein. Sepharose 62-69 interferon gamma Homo sapiens 132-141 6177002-8 1982 Sulfhydryl-specific binding of native IFN-gamma to an Affi-Gel 501 column suggested that this IFN contains free sulfhydryl. Sulfhydryl Compounds 112-122 interferon gamma Homo sapiens 38-47 6329718-4 1982 Restriction fragments that hybridized with 32P-labeled cDNA probes were subcloned into plasmids and the complete sequence of the IFN-gamma gene was determined. Phosphorus-32 43-46 interferon gamma Homo sapiens 129-138 6182256-4 1982 Formamide sucrose gradient centrifugation analysis indicated that the mRNA which codes for IFN-gamma sediments at around 15 S. The profile, however, suggested a size heterogeneity of IFN-specific mRNA. Sucrose 10-17 interferon gamma Homo sapiens 91-100 6167986-1 1981 gamma (immune) interferon (IFN-gamma) was induced in cultures of fresh human lymphocytes by combined treatment with a phorbol ester (12-O-tetradecanoylphorbol 13-acetate, TPA) and the T cell mitogen phytohemagglutinin (PHA). Phorbol Esters 118-131 interferon gamma Homo sapiens 27-36 6170583-7 1981 IFN produced after stimulation with TPA or mezerein, singly or in combination with phytohemagglutinin, had several properties characteristic of IFN-gamma, e.g., it was largely inactivated by dialysis at pH 2, or after exposure to sodium dodecyl sulfate, whereas it was not neutralized by antibody to IFN-alpha and IFN-beta. Tetradecanoylphorbol Acetate 36-39 interferon gamma Homo sapiens 144-153 6170583-7 1981 IFN produced after stimulation with TPA or mezerein, singly or in combination with phytohemagglutinin, had several properties characteristic of IFN-gamma, e.g., it was largely inactivated by dialysis at pH 2, or after exposure to sodium dodecyl sulfate, whereas it was not neutralized by antibody to IFN-alpha and IFN-beta. mezerein 43-51 interferon gamma Homo sapiens 144-153 6170583-7 1981 IFN produced after stimulation with TPA or mezerein, singly or in combination with phytohemagglutinin, had several properties characteristic of IFN-gamma, e.g., it was largely inactivated by dialysis at pH 2, or after exposure to sodium dodecyl sulfate, whereas it was not neutralized by antibody to IFN-alpha and IFN-beta. Sodium Dodecyl Sulfate 230-252 interferon gamma Homo sapiens 144-153 6170583-8 1981 The stimulatory effect of diterpene esters has proved helpful in producing IFN-gamma for physicochemical analysis and other studies. diterpene esters 26-42 interferon gamma Homo sapiens 75-84 6162895-5 1981 Galactose oxidase- and calcium ionophore-induced interferons were neutralized to undetectable levels by the antiserum to IFN gamma. Calcium 23-30 interferon gamma Homo sapiens 121-130 6167986-1 1981 gamma (immune) interferon (IFN-gamma) was induced in cultures of fresh human lymphocytes by combined treatment with a phorbol ester (12-O-tetradecanoylphorbol 13-acetate, TPA) and the T cell mitogen phytohemagglutinin (PHA). Tetradecanoylphorbol Acetate 133-169 interferon gamma Homo sapiens 27-36 6167986-1 1981 gamma (immune) interferon (IFN-gamma) was induced in cultures of fresh human lymphocytes by combined treatment with a phorbol ester (12-O-tetradecanoylphorbol 13-acetate, TPA) and the T cell mitogen phytohemagglutinin (PHA). Tetradecanoylphorbol Acetate 171-174 interferon gamma Homo sapiens 27-36 6167986-2 1981 Compared to the IFN-gamma yields obtained with PHA induction alone, the inclusion of TPA caused a significant enhancement of IFN-gamma production. Tetradecanoylphorbol Acetate 85-88 interferon gamma Homo sapiens 125-134 6167986-5 1981 Sucrose density gradient centrifugation analysis showed that IFN-gamma mRNA sedimented at 15 S, suggesting that it contains a total of about 1400 nucleotides. Sucrose 0-7 interferon gamma Homo sapiens 61-70 6165014-1 1981 Human gamma (immune) interferon (IFN-gamma) was produced in lymphocyte cultures stimulated with a phorbol ester (12-O-tetradecanoylphorbol 13-acetate) and purified phytohemagglutinin. Phorbol Esters 98-111 interferon gamma Homo sapiens 33-42 6165014-1 1981 Human gamma (immune) interferon (IFN-gamma) was produced in lymphocyte cultures stimulated with a phorbol ester (12-O-tetradecanoylphorbol 13-acetate) and purified phytohemagglutinin. Tetradecanoylphorbol Acetate 113-149 interferon gamma Homo sapiens 33-42 6165014-3 1981 A purification process for IFN-gamma was developed consisting of sequential chromatographic separations on controlled-pore glass, concanavalin A-Sepharose, and Bio-Gel P-200. Sepharose 145-154 interferon gamma Homo sapiens 27-36 33957086-0 2021 Oleic acid and oleoylethanolamide decrease interferon-gamma-induced expression of PD-L1 and induce apoptosis in human lung carcinoma cells. Oleic Acid 0-10 interferon gamma Homo sapiens 43-59 6173591-0 1981 Use of tunicamycin to prepare carbohydrate-deficient human immune interferon. Tunicamycin 7-18 interferon gamma Homo sapiens 59-76 6173591-0 1981 Use of tunicamycin to prepare carbohydrate-deficient human immune interferon. Carbohydrates 30-42 interferon gamma Homo sapiens 59-76 34000471-3 2021 Fluoxetine and 5-HT suppressed IL-17, IFN-gamma and GM-CSF production by stimulated SD4+ T-cells in both groups. Fluoxetine 0-10 interferon gamma Homo sapiens 38-47 33957086-0 2021 Oleic acid and oleoylethanolamide decrease interferon-gamma-induced expression of PD-L1 and induce apoptosis in human lung carcinoma cells. oleoylethanolamide 15-33 interferon gamma Homo sapiens 43-59 34000471-3 2021 Fluoxetine and 5-HT suppressed IL-17, IFN-gamma and GM-CSF production by stimulated SD4+ T-cells in both groups. Serotonin 15-19 interferon gamma Homo sapiens 38-47 33957086-8 2021 In A549 cells, oleic acid and OEA decreased IFN-gamma-induced expression of PD-L1, Bax, Bcl-2, and caspase 3. Oleic Acid 15-25 interferon gamma Homo sapiens 44-53 33957086-8 2021 In A549 cells, oleic acid and OEA decreased IFN-gamma-induced expression of PD-L1, Bax, Bcl-2, and caspase 3. oleoylethanolamide 30-33 interferon gamma Homo sapiens 44-53 33957086-9 2021 Oleic acid and OEA decreased IFN-gamma-induced phosphorylation of STAT. Oleic Acid 0-10 interferon gamma Homo sapiens 29-38 33957086-9 2021 Oleic acid and OEA decreased IFN-gamma-induced phosphorylation of STAT. oleoylethanolamide 15-18 interferon gamma Homo sapiens 29-38 33957086-11 2021 Therefore, oleic acid and OEA may prevent cancer formation through STAT phosphorylation with IFN-gamma. Oleic Acid 11-21 interferon gamma Homo sapiens 93-102 33957086-11 2021 Therefore, oleic acid and OEA may prevent cancer formation through STAT phosphorylation with IFN-gamma. oleoylethanolamide 26-29 interferon gamma Homo sapiens 93-102 33887367-6 2021 The signature apparently relates to TNF- alpha, IL-1alpha, IL-1beta, IFN-alpha, IFN-beta, and IFN-gamma signaling, but not IL-6 signaling, suggesting that therapeutic effect of dexamethasone in COVID-19 does not involve IL-6 pathway. Dexamethasone 177-190 interferon gamma Homo sapiens 94-103 33982762-0 2021 3,4,5-Trihydroxycinnamic acid exerts anti-inflammatory effects on TNF-alpha/IFN-gamma-stimulated HaCaT cells. 3,4,5-trihydroxycinnamic acid 0-29 interferon gamma Homo sapiens 76-85 33965784-4 2021 We found that amlexanox enhanced production of interferon (IFN)-gamma, an indicator of T cell activation, by anti-PD-1 mAb. amlexanox 14-23 interferon gamma Homo sapiens 47-69 33965784-8 2021 The combination of amlexanox and anti-PD-1 mAb increased the expression of Ifng encoding IFN-gamma, IFN-gamma-related genes, Cd274 encoding PD-L1, and cytotoxic T cell-related genes in tumors. amlexanox 19-28 interferon gamma Homo sapiens 75-79 33965784-8 2021 The combination of amlexanox and anti-PD-1 mAb increased the expression of Ifng encoding IFN-gamma, IFN-gamma-related genes, Cd274 encoding PD-L1, and cytotoxic T cell-related genes in tumors. amlexanox 19-28 interferon gamma Homo sapiens 89-98 33965784-8 2021 The combination of amlexanox and anti-PD-1 mAb increased the expression of Ifng encoding IFN-gamma, IFN-gamma-related genes, Cd274 encoding PD-L1, and cytotoxic T cell-related genes in tumors. amlexanox 19-28 interferon gamma Homo sapiens 100-109 33831579-9 2021 Serum chemerin and IFN-gamma were strongly correlated (P < 0.001) and were positively correlated with BMI, WC, total-FM, trunk-FM, HOMA-IR, cholesterol, triglycerides and negatively correlated with HDLC. Cholesterol 140-151 interferon gamma Homo sapiens 19-28 33831579-9 2021 Serum chemerin and IFN-gamma were strongly correlated (P < 0.001) and were positively correlated with BMI, WC, total-FM, trunk-FM, HOMA-IR, cholesterol, triglycerides and negatively correlated with HDLC. Triglycerides 153-166 interferon gamma Homo sapiens 19-28 33982762-2 2021 The present study investigated the anti-inflammatory activity of THCA in a tumor necrosis factor-alpha/interferon-gamma (TI) mixture-stimulated human keratinocyte cell line. thca 65-69 interferon gamma Homo sapiens 103-119 32786025-9 2021 Examination of 27 cytokines showed significant enhancements in 8 factors, including intracellular indoleamine 2, 3-dioxygenase (IDO), on HEP/COL multilayers when stimulated with interferon-gamma (IFN-gamma). 1H-indol-2-amine 98-109 interferon gamma Homo sapiens 178-194 33469922-9 2021 GC caused systemic IL-2 release acutely, and increased gliadin peptide-stimulated IFN-gamma ELISpot and whole blood CRA responses. gliadin peptide 55-70 interferon gamma Homo sapiens 82-91 33721618-5 2021 Moreover, blockade of mini-TrpRS, either by siRNA, or the cognate amino acid and decoy substrate D-Tryptophan to prevent mini-TrpRS signaling, resulted in a marked reduction in expression of the purinergic receptor P2X 7 (P2RX7) in monocytes activated by IFNgamma. D-Tryptophan 97-109 interferon gamma Homo sapiens 255-263 33687725-3 2021 We investigated whether the IFN-gamma deficiency could interfere with nigrostriatal degeneration induced by the neurotoxin 6-hydroxydopamine, L-DOPA-induced dyskinesia, and the neuroinflammatory features as astrogliosis, microgliosis, and induced nitric oxide synthase (iNOS) immunoreactivity induced by L-DOPA treatment. Oxidopamine 123-140 interferon gamma Homo sapiens 28-37 33714187-6 2021 In vivo antitumor studies reveal that HA-AuNR/M-M2pep NPs-mediated PTT and M2-TAMs depletion recruit TILs, activate effector T lymphocytes, secrete antitumor cytokines (e.g. IFN-gamma, TNF-alpha), and effectively inhibit the growth of tumor. Bialaphos 67-70 interferon gamma Homo sapiens 174-183 33484204-7 2021 Strong decreases of deleterious cytokines in the CNS (GM-CSF, TNF-alpha, IL-17A) and spleen (IL-2, IFN-gamma) stand as unique features of the combined drugs while the potent therapeutic activity of testosterone on peripheral immune cells contributes to increase tolerogenic CD11c+ dendritic cells, reduce the clonal expansion of conventional CD4+ T cells and increase CD4+ Foxp3+ regulatory T cells. Testosterone 198-210 interferon gamma Homo sapiens 99-108 33687725-3 2021 We investigated whether the IFN-gamma deficiency could interfere with nigrostriatal degeneration induced by the neurotoxin 6-hydroxydopamine, L-DOPA-induced dyskinesia, and the neuroinflammatory features as astrogliosis, microgliosis, and induced nitric oxide synthase (iNOS) immunoreactivity induced by L-DOPA treatment. Levodopa 142-148 interferon gamma Homo sapiens 28-37 32786025-9 2021 Examination of 27 cytokines showed significant enhancements in 8 factors, including intracellular indoleamine 2, 3-dioxygenase (IDO), on HEP/COL multilayers when stimulated with interferon-gamma (IFN-gamma). 1H-indol-2-amine 98-109 interferon gamma Homo sapiens 196-205 33687725-3 2021 We investigated whether the IFN-gamma deficiency could interfere with nigrostriatal degeneration induced by the neurotoxin 6-hydroxydopamine, L-DOPA-induced dyskinesia, and the neuroinflammatory features as astrogliosis, microgliosis, and induced nitric oxide synthase (iNOS) immunoreactivity induced by L-DOPA treatment. Levodopa 304-310 interferon gamma Homo sapiens 28-37 33845054-7 2021 Arsenic exposure levels of the subjects showed significant positive associations with serum Th2-mediators- interleukin (IL)-4, IL-5, IL-13, and eotaxin without any significant changes in Th1 mediators- interferon-gamma and tumor necrosis factor-alpha. Arsenic 0-7 interferon gamma Homo sapiens 202-250 34050151-4 2021 Mechanistically, human A2AR-edited CAR T cells are significantly resistant to adenosine-mediated transcriptional changes, resulting in enhanced production of cytokines including IFNgamma and TNF, and increased expression of JAK-STAT signaling pathway associated genes. Adenosine 78-87 interferon gamma Homo sapiens 178-186 33908440-7 2021 Furthermore, genistein inhibited the phosphorylation of ERK and STAT3 to downregulate the expression of cytokines and chemokines, and feedback downregulate phospho-p38 in TNF-alpha/IFN-gamma-induced HaCaT cells. Genistein 13-22 interferon gamma Homo sapiens 181-190 34044769-10 2021 CONCLUSIONS: Together, these results indicated that glycyrrhizin improved psoriasis by inhibiting the expression of IL-17A and IFN-gamma in vivo and suppressed the proliferation of IL-17A-HaCaT cells and the expression of STAT3, p-STAT3, and a-STAT3 by upregulating SIRT1 in vitro. Glycyrrhizic Acid 52-64 interferon gamma Homo sapiens 127-136 34042156-11 2021 Notably, upadacitinib reversed overexpression of inflammatory fibroblast and interferon-gamma effector signature markers. upadacitinib 9-21 interferon gamma Homo sapiens 77-93 34042156-12 2021 CONCLUSIONS: Upadacitinib modulates inflammatory pathways in mucosal lesions of patients with anti-TNF-refractory Crohn"s disease, including inflammatory fibroblast and interferon-gamma-expressing cytotoxic T cell compartments. upadacitinib 13-25 interferon gamma Homo sapiens 169-185 34050092-4 2021 IFNgamma values were reported as concentrations and spot forming units for the QuantiFERON-TB Gold In-Tube (QFT-GIT) and T-SPOT.TB, respectively. quantiferon-tb gold 79-98 interferon gamma Homo sapiens 0-8 34036623-6 2021 Furthermore, lenvatinib reinforced the proteasomal degradation of PD-L1 by blocking the FGFR4-GSK3beta axis and rescued the sensitivity of interferon-gamma-pretreated HCC cells to T-cell killing by targeting FGFR4. lenvatinib 13-23 interferon gamma Homo sapiens 139-155 34029575-5 2021 In addition, CAP treatment reduced the infiltration of CD11c+ dendritic cells, CD3+ T cells, and CD8+ T cells; inhibited the release of chemokine (C-X-C motif) ligand 10 and cytokine interferon-gamma; and enhanced cellular resistance to oxidative stress and excessive immune response by enhancing the expression of the transcription factor Nrf2 and attenuating the activity of inducible nitric oxide synthase. cap 13-16 interferon gamma Homo sapiens 183-199 34009705-8 2021 After repetitive stimulation, SPESP1-specific helper T-cells were obtained; these cells produced interferon-gamma against HLA-matched tumor cell lines treated with 5Aza. Decitabine 164-168 interferon gamma Homo sapiens 97-113 33993101-0 2021 Cyclosporin A impairs neurogenesis and cognitive abilities in brain development via the IFN-gamma-Shh-BDNF pathway. Cyclosporine 0-13 interferon gamma Homo sapiens 88-97 34015733-0 2021 Synthesis of pH-sensitive hyaluronic acid nanogels loaded with paclitaxel and interferon gamma: Characterization and effect on the A549 lung carcinoma cell line. Hyaluronic Acid 26-41 interferon gamma Homo sapiens 78-94 34015733-7 2021 The results of MTT assay showed that the survival rate of healthy cells treated with PTX and IFN-gamma-loaded nanogels was 2.15 and 2.39 times higher than cancer cells, respectively. monooxyethylene trimethylolpropane tristearate 15-18 interferon gamma Homo sapiens 93-102 33982373-7 2022 The results showed that butyrate could significantly reduce pro-inflammatory cytokines (IL-17A, IFN-gamma, TNF- alpha) in the ileum and colon while promoting IL-10 expression in the colon. Butyrates 24-32 interferon gamma Homo sapiens 96-105 34025661-10 2021 The mentioned ratios and acetate levels correlated negatively with the pro-inflammatory biomarker IFNG, indicating an inverse relation between acetate and inflammation. Acetates 25-32 interferon gamma Homo sapiens 98-102 34040604-6 2021 Moreover, Y111 increased the cytotoxicity of the expanded Vgamma2Vdelta2 T cells against various NSCLC-derived tumor cell lines with the releases of granzyme B, IFNgamma, and TNFalpha in vitro. y111 10-14 interferon gamma Homo sapiens 161-169 33965881-2 2021 This study was aimed to assess the effect of in vitro calcitriol immunomodulatory effect on IL-6, IL-10 and IFN-gamma in elderly patients who were fit, pre-frail and frail to see which group of patients might get the most benefit of calcitriol. Calcitriol 54-64 interferon gamma Homo sapiens 108-117 33976173-3 2021 Here, we identify NAMPT, the rate limiting enzyme in NAD salvage synthesis, as a target of STAT1 during cellular activation by interferon gamma, an important driver of macrophage polarization and antitumor responses. NAD 53-56 interferon gamma Homo sapiens 127-143 33965879-0 2021 Paeoniflorin attenuates the allergic contact dermatitis response via inhibiting the IFN-gamma production and the NF-kappaB/IkappaBalpha signaling pathway in T lymphocytes. peoniflorin 0-12 interferon gamma Homo sapiens 84-93 34025661-10 2021 The mentioned ratios and acetate levels correlated negatively with the pro-inflammatory biomarker IFNG, indicating an inverse relation between acetate and inflammation. Acetates 143-150 interferon gamma Homo sapiens 98-102 34025661-11 2021 In contrast, the proportion of butyrate was found higher in MS patients in the multivariate analysis, and both butyrate and valerate correlated positively with proinflammatory cytokines (IFNG and TNF), suggesting complex bidirectional regulatory properties of SCFAs. Butyrates 111-119 interferon gamma Homo sapiens 187-191 33949684-6 2021 We show that both Tregs and RA+ Tregs could be expanded in large numbers and the presence of rapamycin is essential to inhibit the growth of IFN-gamma producing cells. Sirolimus 93-102 interferon gamma Homo sapiens 141-150 33942546-8 2021 In addition, copanlisib impaired the activation of CD4+ CD25+ T cells (anti-CD3: 42.15 +- 21.46; anti-CD3 + copanlisib: 26.06 +- 21.82 p = .013) and the secretion of cytokines (IFNgamma: anti-CD3: 6332.0 +- 5707.61 pmol/ml; anti-CD3 + copanlisib: 6332.0 +- 5707.61, p = .018). copanlisib 13-23 interferon gamma Homo sapiens 177-185 33444083-8 2021 We observed that participants on 3000 mg/day dose of metformin had significantly lower levels of TNF-alpha (p < .001) and IFN-gamma (p = .014) compared to those on other dosages (1000 mg and 2000 mg/day). Metformin 53-62 interferon gamma Homo sapiens 122-131 34041472-0 2021 Bortezomib treatment for refractory nontuberculous mycobacterial infection in the setting of interferon gamma autoantibodies. Bortezomib 0-10 interferon gamma Homo sapiens 93-109 33958648-11 2021 Progesterone and its metabolites reduced TNF-alpha and IFN-gamma production in CD4+ and CD8+ T cells. Progesterone 0-12 interferon gamma Homo sapiens 55-64 34012961-14 2021 Indeed, the specific Arp2/3 inhibitor CK666 ameliorated TNFalpha/IFNgamma-induced permeability in established Caco-2 monolayers by preventing TJ disruption. CK-0944666 38-43 interferon gamma Homo sapiens 65-73 32868906-6 2021 Furthermore, DCV treatment strongly inhibited IFN-gamma-induced STAT3 phosphorylation but had no significant effect on IFN-gamma-induced STAT1 and STAT5 phosphorylation in the two breast cancer cell lines. curvularin 13-16 interferon gamma Homo sapiens 46-55 33705988-6 2021 Application of clinically used JAK/STAT inhibitors, tofacitinib and baricitinib, fully prevented IFNgamma-induced cardiomyopathy, confirming the critical roles of this signaling pathway in inflammatory cardiac disease. tofacitinib 52-63 interferon gamma Homo sapiens 97-105 33957277-5 2021 Kinetic assays showed similar internalization of EAs in unstimulated RAW and non-phagocytic HeLa cells but increased in LPS/IFN-gamma stimulated RAW cells. CHEMBL4167713 49-52 interferon gamma Homo sapiens 124-133 33140189-0 2021 IL-15 superagonist N-803 improves IFNgamma production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells. n-803 19-24 interferon gamma Homo sapiens 34-42 33140189-11 2021 Treating OC spheroids with HPC-NK cells and N-803 increased IFNgamma-induced CXCL10 secretion, and target killing after prolonged exposure. n-803 44-49 interferon gamma Homo sapiens 60-68 34012433-9 2021 IL-33 restored the suppressive function of Tregs, reduced interferon (IFN)-gamma production by Tregs and decreased the activation of orbital fibroblasts (OFs) cocultured with Tregs in IOI. tregs 95-100 interferon gamma Homo sapiens 58-80 34012433-9 2021 IL-33 restored the suppressive function of Tregs, reduced interferon (IFN)-gamma production by Tregs and decreased the activation of orbital fibroblasts (OFs) cocultured with Tregs in IOI. tregs 95-100 interferon gamma Homo sapiens 58-80 33175182-9 2021 Significantly, beta-glucan worked synergistically with IFN-gamma to reverse the risk signature by repolarizing the MPE-Mphi toward the M1 pattern, enhancing anti-cancer activity. beta-Glucans 15-26 interferon gamma Homo sapiens 55-64 33622713-2 2021 The tryptophan catabolizing enzyme IDO1 (indoleamine 2,3-dioxygenase) has been implicated in promoting neovascularization through its positioning as a key regulatory node between the inflammatory cytokines IFNgamma and IL6. Tryptophan 4-14 interferon gamma Homo sapiens 206-214 33705988-6 2021 Application of clinically used JAK/STAT inhibitors, tofacitinib and baricitinib, fully prevented IFNgamma-induced cardiomyopathy, confirming the critical roles of this signaling pathway in inflammatory cardiac disease. baricitinib 68-79 interferon gamma Homo sapiens 97-105 32816920-4 2021 We evaluated the ability of the cyclin-dependent kinase (CDK) inhibitor dinaciclib to block IFNG-induced IDO1 and CD274 expression in 24 human and mouse cancer cell lines as well as in primary cancer cells from patients with PDAC or ovarian carcinoma. dinaciclib 72-82 interferon gamma Homo sapiens 92-96 33932293-10 2021 LDNs enhanced autologous T-cell proliferation, IL-6 and IFN-gamma production. ldns 0-4 interferon gamma Homo sapiens 56-65 32816920-10 2021 CDK1/2/5 inhibition by dinaciclib provides a novel strategy to overcome IFNG-triggered acquired resistance in pancreatic tumour immunity. dinaciclib 23-33 interferon gamma Homo sapiens 72-76 33475942-5 2021 IFN-beta-induced STAT1 phosphorylation/dephosphorylation levels and PMA/ionomycin-stimulated intracellular IL-17A/IFN-gamma production in CD4+ T cells were evaluated. Ionomycin 72-81 interferon gamma Homo sapiens 114-123 33317858-8 2021 Treatment of 5 patients with recalcitrant GA with tofacitinib inhibited IFN-gamma and oncostatin M, as well as IL-15 and IL-21, activity and resulted in clinical and histologic disease remission in 3 patients and marked improvement in the other 2. tofacitinib 50-61 interferon gamma Homo sapiens 72-81 33863532-9 2021 Furthermore, we also found that administration of ginkgolides significantly decreased the levels of interferon (IFN)-gamma and interleukin-12 (IL)-12 in GBS patients. Ginkgolides 50-61 interferon gamma Homo sapiens 100-122 33934108-6 2021 AT IFNgamma+ NK cells, but not CD4, CD8 or gammadelta T cells, were positively associated with glucose levels, glycated hemoglobin (HbA1c) and IR. Glucose 95-102 interferon gamma Homo sapiens 3-11 33863532-11 2021 Ginkgolides also suppressed inflammation response by decreasing pro-inflammatory cytokines IFN-gamma and IL-12, suggesting ginkgolides had potential therapeutic effects on GBS patients and EAN in the future. Ginkgolides 0-11 interferon gamma Homo sapiens 91-100 33863532-11 2021 Ginkgolides also suppressed inflammation response by decreasing pro-inflammatory cytokines IFN-gamma and IL-12, suggesting ginkgolides had potential therapeutic effects on GBS patients and EAN in the future. Ginkgolides 123-134 interferon gamma Homo sapiens 91-100 33482039-7 2021 After 24 months of ETV treatment, the frequency and cytokine production of ILC2s (IL-4, IL-13, IFN-gamma, TNF-alpha) decreased with increased ILC1/ILC2 and decreased ILC2/ILC3 ratios, revealing a close association with disease status in LC patients. entecavir 19-22 interferon gamma Homo sapiens 95-104 33760166-9 2021 miR-101-3p negatively regulated IL-10 and IFN-gamma expression in SLE samples and was demonstrated to target MAPK1. mir-101-3p 0-10 interferon gamma Homo sapiens 42-51 33610575-0 2021 Vincamine protects against cisplatin induced nephrotoxicity via activation of Nrf2/HO-1 and hindering TLR4/ IFN-gamma/CD44 cells inflammatory cascade. Vincamine 0-9 interferon gamma Homo sapiens 108-117 33610575-0 2021 Vincamine protects against cisplatin induced nephrotoxicity via activation of Nrf2/HO-1 and hindering TLR4/ IFN-gamma/CD44 cells inflammatory cascade. Cisplatin 27-36 interferon gamma Homo sapiens 108-117 33760111-8 2021 IFN-gamma was found to enhance poly(dA:dT)-induced pyroptosis of cells and cytokine production. poly( 31-36 interferon gamma Homo sapiens 0-9 33760111-8 2021 IFN-gamma was found to enhance poly(dA:dT)-induced pyroptosis of cells and cytokine production. amsonic acid 36-38 interferon gamma Homo sapiens 0-9 33760166-10 2021 Increases in MAPK1 expression eliminated miR-101-3p inhibition of IL-10 and IFN-gamma. mir-101-3p 41-51 interferon gamma Homo sapiens 76-85 33760111-8 2021 IFN-gamma was found to enhance poly(dA:dT)-induced pyroptosis of cells and cytokine production. Thymidine 39-42 interferon gamma Homo sapiens 0-9 33760166-12 2021 In addition, treatment with BAY11-7085 (NF-kappaB activator) was demonstrated to reverse the inhibitory effects of miR-101-3p expression on both IL-10 and IFN-gamma in SLE PBMCs. BAY 11-7085 28-38 interferon gamma Homo sapiens 155-164 33760166-12 2021 In addition, treatment with BAY11-7085 (NF-kappaB activator) was demonstrated to reverse the inhibitory effects of miR-101-3p expression on both IL-10 and IFN-gamma in SLE PBMCs. mir-101 115-122 interferon gamma Homo sapiens 155-164 33760166-13 2021 BAY11-7082 also markedly reduced MAPK1-induced increases in IL-10 and IFN-gamma in SLE PBMCs. 3-(4-methylphenylsulfonyl)-2-propenenitrile 0-10 interferon gamma Homo sapiens 70-79 33965175-0 2021 Ruxolitinib Inhibits IFNgamma Licensing of Human Bone Marrow Derived Mesenchymal Stromal Cells. ruxolitinib 0-11 interferon gamma Homo sapiens 21-29 33908204-7 2021 AEAR at a medium dose stimulated Th1/Th2-type response through interleukin-4 and interferon-gamma secreted by CD4+ T cells. aear 0-4 interferon gamma Homo sapiens 81-97 33965175-7 2021 We aimed to define the effect of ruxolitinib on the immunobiology of MSCs that are modulated by IFNgamma. ruxolitinib 33-44 interferon gamma Homo sapiens 96-104 33965175-12 2021 IFNgamma-induced immunosuppressive molecules IDO and PDL-1 were also inhibited by ruxolitinib on MSCs. ruxolitinib 82-93 interferon gamma Homo sapiens 0-8 33965175-8 2021 Human bone marrow derived MSCs, peripheral blood mononuclear cells (PBMCs), and primary bone marrow aspirates were analyzed for their sensitivity to ruxolitinib-mediated blocking of IFNgamma-induced STAT-1 phosphorylation and downstream effector molecules, utilizing Western blot, flow cytometry, secretome analysis, and phosflow techniques. ruxolitinib 149-160 interferon gamma Homo sapiens 182-190 33965175-13 2021 Comparative analysis with PBMCs has demonstrated that MSCs are as equal as to HLADR+ PBMC populations in responding to ruxolitinib-mediated inhibition of IFNgamma-induced STAT-1 phosphorylation. ruxolitinib 119-130 interferon gamma Homo sapiens 154-162 33965175-14 2021 Ex vivo analysis of human marrow aspirates has demonstrated that ruxolitinib blocks IFNgamma-induced STAT-1 phosphorylation in CD45+/-HLADR+/- populations at different levels, which is depending on their sensitivity to IFNgamma responsiveness. ruxolitinib 65-76 interferon gamma Homo sapiens 84-92 33965175-9 2021 IFNgamma-induced cytostatic effects on MSCs are reversed by ruxolitinib. ruxolitinib 60-71 interferon gamma Homo sapiens 0-8 33965175-14 2021 Ex vivo analysis of human marrow aspirates has demonstrated that ruxolitinib blocks IFNgamma-induced STAT-1 phosphorylation in CD45+/-HLADR+/- populations at different levels, which is depending on their sensitivity to IFNgamma responsiveness. ruxolitinib 65-76 interferon gamma Homo sapiens 219-227 33965175-10 2021 Ruxolitinib inhibits IFNgamma and secretome of activated peripheral PBMC-induced STAT-1 phosphorylation on human bone marrow derived MSCs. ruxolitinib 0-11 interferon gamma Homo sapiens 21-29 33965175-11 2021 In addition, ruxolitinib inhibits IFNgamma-induced pro-GVHD pathways on MSCs, which includes HLAABC(MHCI), HLADR(MHCII), CX3CL1, and CCL2. ruxolitinib 13-24 interferon gamma Homo sapiens 34-42 33995375-8 2021 Peripheral blood mononuclear cells from all patients were stimulated to proliferate and secrete IFN-gamma with nitroso sulfamethoxazole. nitroso sulfamethoxazole 111-135 interferon gamma Homo sapiens 96-105 33544449-7 2021 Islets exposed to acute hypoxia (1-2% O2 ) or to inflammatory cytokines (including IFN-gamma, TNF-alpha, IL-B) in vitro undergo apoptosis and a rapid decline in glucose-stimulated insulin secretion. Glucose 161-168 interferon gamma Homo sapiens 83-92 33995375-9 2021 All sulfamethoxazole and nitroso sulfamethoxazole specific T cell clones expressed the CD4+ phenotype and strongly secreted IL-13 as well as IFN-gamma, granzyme B and IL-22. Sulfamethoxazole 4-20 interferon gamma Homo sapiens 141-150 33740613-5 2021 Compared with HP-PRRSV-inoculated MDM, stimulation with rutin, alpha-tocopherol, and l-ascorbic acid, but not beta-carotene significantly enhanced mRNA expression levels of IRF3, IRF7, STING, OPN, IFNalpha, IFNbeta, and IFNgamma in HP-PRRSV-inoculated MDM. Rutin 56-61 interferon gamma Homo sapiens 220-228 33995375-9 2021 All sulfamethoxazole and nitroso sulfamethoxazole specific T cell clones expressed the CD4+ phenotype and strongly secreted IL-13 as well as IFN-gamma, granzyme B and IL-22. nitroso sulfamethoxazole 25-49 interferon gamma Homo sapiens 141-150 33740613-5 2021 Compared with HP-PRRSV-inoculated MDM, stimulation with rutin, alpha-tocopherol, and l-ascorbic acid, but not beta-carotene significantly enhanced mRNA expression levels of IRF3, IRF7, STING, OPN, IFNalpha, IFNbeta, and IFNgamma in HP-PRRSV-inoculated MDM. alpha-Tocopherol 63-79 interferon gamma Homo sapiens 220-228 33998900-7 2021 Results: Tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6, and interferon gamma were the most commonly studied pro-inflammatory cytokines and their levels were consistently reduced after treatment with CBD, CBG, or CBD+THC, but not with THC alone. Cannabidiol 211-214 interferon gamma Homo sapiens 72-88 33740613-5 2021 Compared with HP-PRRSV-inoculated MDM, stimulation with rutin, alpha-tocopherol, and l-ascorbic acid, but not beta-carotene significantly enhanced mRNA expression levels of IRF3, IRF7, STING, OPN, IFNalpha, IFNbeta, and IFNgamma in HP-PRRSV-inoculated MDM. Ascorbic Acid 85-100 interferon gamma Homo sapiens 220-228 33909926-4 2021 IFN-gamma-induced expression of CXCL10 mRNA in HaCaT cells, a human keratinocyte cell line, and human epithelial keratinocytes were also inhibited by H2 O2 or endoplasmic reticulum (ER) stress inducers. Hydrogen Peroxide 150-155 interferon gamma Homo sapiens 0-9 33998900-7 2021 Results: Tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6, and interferon gamma were the most commonly studied pro-inflammatory cytokines and their levels were consistently reduced after treatment with CBD, CBG, or CBD+THC, but not with THC alone. cannabigerol 216-219 interferon gamma Homo sapiens 72-88 33998900-7 2021 Results: Tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6, and interferon gamma were the most commonly studied pro-inflammatory cytokines and their levels were consistently reduced after treatment with CBD, CBG, or CBD+THC, but not with THC alone. Cannabidiol 224-227 interferon gamma Homo sapiens 72-88 33954150-4 2021 Priming leukemia cells with AZA increased CAR T cell/target cell conjugation and target cell killing, promoted CAR T cell divisions and expanded IFNgamma+ effector T cells in co-cultures with CD19+ leukemia Nalm-6 and Raji cells. Azacitidine 28-31 interferon gamma Homo sapiens 145-153 33909926-5 2021 Conversely, a mixture of antioxidants, Trolox and ascorbic acid, and the ER stress inhibitor salubrinal partially counteracted the inhibitory effect of UVB on IFN-gamma-induced CXCL10 mRNA expression in HaCaT cells. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 39-45 interferon gamma Homo sapiens 159-168 33909926-5 2021 Conversely, a mixture of antioxidants, Trolox and ascorbic acid, and the ER stress inhibitor salubrinal partially counteracted the inhibitory effect of UVB on IFN-gamma-induced CXCL10 mRNA expression in HaCaT cells. Ascorbic Acid 50-63 interferon gamma Homo sapiens 159-168 33909926-5 2021 Conversely, a mixture of antioxidants, Trolox and ascorbic acid, and the ER stress inhibitor salubrinal partially counteracted the inhibitory effect of UVB on IFN-gamma-induced CXCL10 mRNA expression in HaCaT cells. salubrinal 93-103 interferon gamma Homo sapiens 159-168 33909926-7 2021 These observations suggested that ER stress and the generation of reactive oxygen species are essential for the inhibitory effect of UVB on IFN-gamma-induced CXCL10 mRNA in keratinocytes. Oxygen 75-81 interferon gamma Homo sapiens 140-149 33899926-5 2021 Tofacitinib down-regulated inflammatory cytokines by stimulated B (IL-6 and TNF-alpha) and T (IFN-gamma, IL-17, or TNF-alpha) cells in the short term while a significant reduction of IL-17 and IL-6 levels in PBMC supernatant was also observed. tofacitinib 0-11 interferon gamma Homo sapiens 94-103 33901737-11 2021 Finally, intraperitoneal administration of 7HF lowers serum inflammatory cytokines, IFNgamma and IL6, and reduces the effects of DSS-induced colitis with respect to colon length and colon damage. 7-hydroxyfrullanolide 43-46 interferon gamma Homo sapiens 84-92 33891607-0 2021 Mesencephalic astrocyte-derived neurotrophic factor is secreted from interferon-gamma-activated tumor cells through ER calcium depletion. Calcium 119-126 interferon gamma Homo sapiens 69-85 33891607-10 2021 However, IFN-gamma induced ER calcium depletion, which was necessary for MANF secretion, as Dantrolene, an inhibitor of ER calcium release, prevented its secretion. Calcium 30-37 interferon gamma Homo sapiens 9-18 33601665-8 2021 Furthermore, PFOS and PFOA enhanced the Th2 response in Jurkat cells via STAT6 activation; and the effect of PFOS exposure on GATA-3, IL-4 and IFN-gamma was blocked after the expression of STAT6 was suppressed in Jurkat cells, however, the effects of PFOA exposure were only partially blocked. perfluorooctanoic acid 22-26 interferon gamma Homo sapiens 143-152 33959001-11 2021 In MSCs, atorvastatin and aspirin combination reduced the release of pro-inflammatory cytokines such as IL-6, IL-8, MCP-1 and IFN-gamma. Atorvastatin 9-21 interferon gamma Homo sapiens 126-135 33959001-11 2021 In MSCs, atorvastatin and aspirin combination reduced the release of pro-inflammatory cytokines such as IL-6, IL-8, MCP-1 and IFN-gamma. Aspirin 26-33 interferon gamma Homo sapiens 126-135 33907428-2 2021 We presented a case of a household contact of rifampicin-resistant TB revealing reactive IFN-gamma release assay with unsuspicious clinical and radiologic examinations. Rifampin 46-56 interferon gamma Homo sapiens 89-98 33601665-8 2021 Furthermore, PFOS and PFOA enhanced the Th2 response in Jurkat cells via STAT6 activation; and the effect of PFOS exposure on GATA-3, IL-4 and IFN-gamma was blocked after the expression of STAT6 was suppressed in Jurkat cells, however, the effects of PFOA exposure were only partially blocked. th2 40-43 interferon gamma Homo sapiens 143-152 33601665-8 2021 Furthermore, PFOS and PFOA enhanced the Th2 response in Jurkat cells via STAT6 activation; and the effect of PFOS exposure on GATA-3, IL-4 and IFN-gamma was blocked after the expression of STAT6 was suppressed in Jurkat cells, however, the effects of PFOA exposure were only partially blocked. perfluorooctane sulfonic acid 109-113 interferon gamma Homo sapiens 143-152 33866462-0 2021 Interferon Gamma-Mediated Oxidative Stress Induces Apoptosis, Neuroinflammation, Zinc Ion Influx, and TRPM2 Channel Activation in Neuronal Cell Line: Modulator Role of Curcumin. Curcumin 168-176 interferon gamma Homo sapiens 0-16 33848524-7 2021 RESULTS: Inflammasome activation and oxidative stress were elevated in CECs following exposure to TNF-alpha and IFN-gamma, which resulted in cell death by pyroptosis as determined by LDH release which was inhibited by the caspase-1 inhibitor Ac-YVAD-cmk. ac-yvad 242-249 interferon gamma Homo sapiens 112-121 33870432-4 2021 Further, NK cells suppressed the proliferation and differentiation of Tregs through secreting IFN-gamma was evidenced in the circulation of NA-treated CHB patients as well as in the liver of HBV-carrier mouse model. tregs 70-75 interferon gamma Homo sapiens 94-103 33617828-11 2021 Rofecoxib, a specific COX-2 inhibitor, mitigated IFN-gamma-induced PD-L1 expression. rofecoxib 0-9 interferon gamma Homo sapiens 49-58 33866462-7 2021 The IFNg treatment further increased cell death, cell debris amount, apoptosis, and cytokine generations (IL-1beta, IL-6, and TNF-alpha) which were due to increased cytosolic and mitochondrial ROS generations as well as increased activations of caspase-3 and caspase-9. ros 193-196 interferon gamma Homo sapiens 4-8 33859108-9 2021 P2 demonstrated a striking increase in the frequency of gag-specific central and effector memory CD8+ T cells producing IFN-gamma, TNF-alpha, and CD107a following anti-PD1 and anti-CTLA-4. P-2 0-2 interferon gamma Homo sapiens 120-129 33859108-9 2021 P2 demonstrated a striking increase in the frequency of gag-specific central and effector memory CD8+ T cells producing IFN-gamma, TNF-alpha, and CD107a following anti-PD1 and anti-CTLA-4. Glycosaminoglycans 56-59 interferon gamma Homo sapiens 120-129 33935778-10 2021 Activated LPTC from IBD patients showed low proliferative rates and reduced secretion of TNF-alpha, IL-6, IFN-gamma and IL-13 in the presence of L. kefiri. lptc 10-14 interferon gamma Homo sapiens 106-115 33936816-6 2021 Interestingly, sunitinib was found to have a profoundly suppressive effect of T cell"s capacity to secrete IFN-gamma, indicating that in vivo use of this drug may hinder robust Th1 responses. Sunitinib 15-24 interferon gamma Homo sapiens 107-116 33967617-7 2021 The levels of IL-2, IL-4, and IFN-gamma were greater in the GGO group (all P<0.05). (4r,5r)-5-Amino-1-[2-(1,3-Benzodioxol-5-Yl)ethyl]-4-(2,4,5-Trifluorophenyl)piperidin-2-One 60-63 interferon gamma Homo sapiens 30-39 33851329-8 2022 We found that IL-6, TNF-alpha, IFN-gamma, and LC3II contents increased with the increase in Cr(VI) concentration. chromium hexavalent ion 92-98 interferon gamma Homo sapiens 31-40 33853687-7 2021 Notably, adding CsA to MSCs after IFNgamma pre-stimulation enhances MSC production of IDO. Cyclosporine 16-19 interferon gamma Homo sapiens 34-42 33787860-8 2021 Furthermore, quantitative reverse transcription-polymerase chain reaction demonstrated that bortezomib suppressed messenger RNA expression of proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) in EBV+ T or NK cells from the patients. Bortezomib 92-102 interferon gamma Homo sapiens 212-239 33787860-11 2021 Moreover, the serum concentration of TNF-alpha and IFN-gamma decreased after bortezomib treatment to the models. Bortezomib 77-87 interferon gamma Homo sapiens 51-60 33859303-6 2021 Hu-IL-12 demonstrated functional viability, eliciting specific NK cell-mediated interferon-gamma (IFN-gamma) release and cytotoxic growth restriction of spheroids in vitro. hu-il-12 0-8 interferon gamma Homo sapiens 80-96 33859303-6 2021 Hu-IL-12 demonstrated functional viability, eliciting specific NK cell-mediated interferon-gamma (IFN-gamma) release and cytotoxic growth restriction of spheroids in vitro. hu-il-12 0-8 interferon gamma Homo sapiens 98-107 33850164-5 2021 Cromolyn and a new fluorinated analog dramatically reduced the secretion of a wide spectrum of inflammatory mediators, which included cytokines such as IL-1beta, IL-6, IL-8 and IFN-gamma, and chemokines such as CXCL10, CCL2, CCL3 and CCL4. Cromolyn Sodium 0-8 interferon gamma Homo sapiens 177-186 33921194-8 2021 Furthermore, when macrophages were cocultured with lymphocytes, decitabine induced a reduction in the release of inflammatory cytokines such as IL-1beta, TNF-alpha, and IFN-gamma, maintaining IL-10 production, suggesting that decitabine could potentialize M2 polarization and might be considered as a therapeutic against the exacerbated immune response. Decitabine 64-74 interferon gamma Homo sapiens 169-178 33483752-6 2021 Moreover, we found that Pb-increased quiescence of HSC critically relied on a synergetic action of Pb and IFNgamma on BM-resident macrophages (MΦ), but not a direct action of Pb on HSC. Lead 24-26 interferon gamma Homo sapiens 106-114 33483752-7 2021 Specifically, in steady state, BM-MΦ promoted HSC proliferation; and upon Pb treatment, IFNgamma was induced in the BM, and thereafter Pb in synergism with IFNgamma acted on BM-MΦ to cause BM-MΦ to become suppressive for HSC proliferation, thus leading to increased quiescence of HSC. Lead 78-80 interferon gamma Homo sapiens 92-100 33483752-7 2021 Specifically, in steady state, BM-MΦ promoted HSC proliferation; and upon Pb treatment, IFNgamma was induced in the BM, and thereafter Pb in synergism with IFNgamma acted on BM-MΦ to cause BM-MΦ to become suppressive for HSC proliferation, thus leading to increased quiescence of HSC. Lead 78-80 interferon gamma Homo sapiens 160-168 33483752-7 2021 Specifically, in steady state, BM-MΦ promoted HSC proliferation; and upon Pb treatment, IFNgamma was induced in the BM, and thereafter Pb in synergism with IFNgamma acted on BM-MΦ to cause BM-MΦ to become suppressive for HSC proliferation, thus leading to increased quiescence of HSC. Lead 139-141 interferon gamma Homo sapiens 160-168 33483752-8 2021 Our study suggests that Pb increased the quiescence of HSC via a synergetic action of Pb and IFNgamma on BM-MΦ, which was a previously unrecognized toxicity of Pb. Lead 24-26 interferon gamma Homo sapiens 93-101 33757236-9 2021 Increased blood Pb levels were positively associated with serum levels of IFN-gamma, and negatively associated with serum levels of IL-13. Lead 16-18 interferon gamma Homo sapiens 74-83 33834624-7 2021 Functionally, IL-9/IL-9R signaling reduced the production of IFNgamma-induced toxic reactive oxygen species (ROS) in HPMs. toxic reactive oxygen species 78-107 interferon gamma Homo sapiens 61-69 33834624-7 2021 Functionally, IL-9/IL-9R signaling reduced the production of IFNgamma-induced toxic reactive oxygen species (ROS) in HPMs. Reactive Oxygen Species 109-112 interferon gamma Homo sapiens 61-69 33908712-10 2021 Even though cisplatin treatment reduced the secretion of IFN-gamma and interleukin (IL)-12p40 in co-cultures stimulated with TLDCs, this effect was not significant (p>0.05). Cisplatin 12-21 interferon gamma Homo sapiens 57-66 33908712-11 2021 A doubling of IFN-gamma secretion following cisplatin treatment was observed in at least one of three independent experiments. Cisplatin 44-53 interferon gamma Homo sapiens 14-23 33508280-9 2021 In addition, COP treatment remarkably suppressed the levels of colonic myeloperoxidase (MPO), adhesion molecules and pro-inflammatory cytokines (TNF-alpha, IFN-gamma, IL-1beta, IL-6 and IL-17), while enhanced IL-10 and TGF-beta. coptisine 13-16 interferon gamma Homo sapiens 156-165 33058491-14 2021 CONCLUSION: These results suggest an IL-7-IFNgamma amplification loop involving SGECs and T cells in pSS. pss 101-104 interferon gamma Homo sapiens 42-50 33915703-7 2021 Moreover, in co-culture with allogeneic T cells, DCs loaded with PAM-lysates increased the proportion of cytotoxic IFN-gamma+ granzyme A+ CD8+ T cells and IL-17A-producing T cells and preserved the Th1 response. pam-lysates 65-76 interferon gamma Homo sapiens 115-124 32737836-11 2021 IFNgamma increased the mRNA and protein expression of PD-L1 in the two cell lines, but oxymatrine significantly abolished IFNgamma-elevated PD-L1 levels at both mRNA and protein levels. oxymatrine 87-97 interferon gamma Homo sapiens 122-130 32737836-12 2021 Furthermore, DNA demethylase activity was remarkably increased in IFNgamma-treated CRC cells, which was abolished by oxymatrine concentration-dependently. oxymatrine 117-127 interferon gamma Homo sapiens 66-74 32737836-13 2021 In addition, DNA methyltransferase inhibitor 5-azacytidine considerably abrogated oxymatrine-induced downregulation of PD-L1 mRNA and protein levels in IFNgamma-stimulated CRC cells. Azacitidine 45-58 interferon gamma Homo sapiens 152-160 32737836-13 2021 In addition, DNA methyltransferase inhibitor 5-azacytidine considerably abrogated oxymatrine-induced downregulation of PD-L1 mRNA and protein levels in IFNgamma-stimulated CRC cells. oxymatrine 82-92 interferon gamma Homo sapiens 152-160 32737836-14 2021 CONCLUSION: Oxymatrine suppressed viability and reduced PD-L1 expression in IFNgamma-stimulated CRC cells, which was attributed to enhanced DNA demethylation. oxymatrine 12-22 interferon gamma Homo sapiens 76-84 33516901-5 2021 TCS also induced increases in IFNgamma secretion, however the increases were most consistent after 48 h of exposure rather than within 24 h. Additionally, a role for both p44/42 and p38 MAPK in TCS-stimulated increases in IL-1beta was seen in cells from some donors. Triclosan 0-3 interferon gamma Homo sapiens 30-38 33516901-5 2021 TCS also induced increases in IFNgamma secretion, however the increases were most consistent after 48 h of exposure rather than within 24 h. Additionally, a role for both p44/42 and p38 MAPK in TCS-stimulated increases in IL-1beta was seen in cells from some donors. Triclosan 194-197 interferon gamma Homo sapiens 30-38 33749932-7 2021 An orally available immunotherapeutic-berberine nanomedicine, named NIT-X, has been developed by our group and has shown significantly increased oral bioavailability of berberine, increased IFN-gamma production by CD8+ T cells, and inhibition of mast cell histamine release in vivo, suggesting a protective immune response. Berberine 38-47 interferon gamma Homo sapiens 190-199 33749932-7 2021 An orally available immunotherapeutic-berberine nanomedicine, named NIT-X, has been developed by our group and has shown significantly increased oral bioavailability of berberine, increased IFN-gamma production by CD8+ T cells, and inhibition of mast cell histamine release in vivo, suggesting a protective immune response. nit-x 68-73 interferon gamma Homo sapiens 190-199 33856415-7 2021 Results: Levels of TNF-alpha, IL-1beta, FGF-basic, and IFN-gamma were significantly higher in KPro with glaucoma compared to KPro without (P = 0.020; 0.008; 0.043; 0.018, respectively). kpro 94-98 interferon gamma Homo sapiens 55-64 33856415-10 2021 IL-1beta and IFN-gamma levels were positively correlated with CDR (r = 0.309, P = 0.039 and r = 0.452, P = 0.006, respectively) and IOP (r = 0.292, P = 0.047 and r = 0.368, P = 0.023, respectively). cdr 62-65 interferon gamma Homo sapiens 13-22 33856415-12 2021 Conclusions: TNF-alpha, IL-1beta, FGF-basic, IFN-gamma are elevated in tears of KPro patients with glaucoma and correlate with CDR and IOP. cdr 127-130 interferon gamma Homo sapiens 45-54 32970888-7 2021 Strain CIDCA 5317 significantly increases HLA-DR expression, however when cells are stimulated with IFN-gamma, strain CIDCA 5310 induces the highest value of expression. cidca 5317 7-17 interferon gamma Homo sapiens 100-109 32970888-7 2021 Strain CIDCA 5317 significantly increases HLA-DR expression, however when cells are stimulated with IFN-gamma, strain CIDCA 5310 induces the highest value of expression. cidca 5310 118-128 interferon gamma Homo sapiens 100-109 33639176-3 2021 METHODS: We evaluated baricitinib effect on the IFN-gamma-release and on a panel of soluble factors by multiplex-technology after stimulating whole-blood from 39 COVID-19 patients with SARS-CoV-2 antigens. baricitinib 22-33 interferon gamma Homo sapiens 48-57 33639176-5 2021 RESULTS: In-vitro exogenous addition of baricitinib significantly decreased IFN-gamma response to spike- (median: 0.21, IQR: 0.01-1; spike+baricitinib 1000 nM median: 0.05, IQR: 0-0.18; p < 0.0001) and to the remainder-antigens (median: 0.08 IQR: 0-0.55; remainder-antigens+baricitinib 1000 nM median: 0.03, IQR: 0-0.14; p = 0.0013). baricitinib 40-51 interferon gamma Homo sapiens 76-85 33639176-5 2021 RESULTS: In-vitro exogenous addition of baricitinib significantly decreased IFN-gamma response to spike- (median: 0.21, IQR: 0.01-1; spike+baricitinib 1000 nM median: 0.05, IQR: 0-0.18; p < 0.0001) and to the remainder-antigens (median: 0.08 IQR: 0-0.55; remainder-antigens+baricitinib 1000 nM median: 0.03, IQR: 0-0.14; p = 0.0013). baricitinib 139-150 interferon gamma Homo sapiens 76-85 33639176-5 2021 RESULTS: In-vitro exogenous addition of baricitinib significantly decreased IFN-gamma response to spike- (median: 0.21, IQR: 0.01-1; spike+baricitinib 1000 nM median: 0.05, IQR: 0-0.18; p < 0.0001) and to the remainder-antigens (median: 0.08 IQR: 0-0.55; remainder-antigens+baricitinib 1000 nM median: 0.03, IQR: 0-0.14; p = 0.0013). baricitinib 139-150 interferon gamma Homo sapiens 76-85 33639176-7 2021 Baricitinib did modulate other soluble factors besides IFN-gamma, significantly decreasing the spike-specific-response mediated by IL-17, IL-1beta, IL-6, TNF-alpha, IL-4, IL-13, IL-1ra, IL-10, GM-CSF, FGF, IP-10, MCP-1, MIP-1beta (p <= 0.0156). baricitinib 0-11 interferon gamma Homo sapiens 55-64 33666884-8 2021 While all vitamin D-treated PBMCs showed reduced levels of IFN-gamma production, in vitro treatment of vitamin D showed no influence in IL-10 production. Vitamin D 10-19 interferon gamma Homo sapiens 59-68 33549903-10 2021 PGE2 blockade significantly reduced percentage and proliferation of T CD4+IL-17+ (p = 0.003, p = 0.0018), T CD4+ IFN-gamma+ (p = 0.002, p = 0.0022) and T CD4+IL-17+ IFN-gamma+ (p = 0.004, p = 0.02) cells. Dinoprostone 0-4 interferon gamma Homo sapiens 113-122 33549903-10 2021 PGE2 blockade significantly reduced percentage and proliferation of T CD4+IL-17+ (p = 0.003, p = 0.0018), T CD4+ IFN-gamma+ (p = 0.002, p = 0.0022) and T CD4+IL-17+ IFN-gamma+ (p = 0.004, p = 0.02) cells. Dinoprostone 0-4 interferon gamma Homo sapiens 165-174 33372059-5 2021 M-MDSCs generated via SK-MEL-5 co-culture expressed low levels of human leukocyte antigen (HLA)-DR, high levels of CD33 and CD11b, and suppressed both CD8+ T cell proliferation and IFN-gamma secretion. sk-mel-5 22-30 interferon gamma Homo sapiens 181-190 33518366-9 2021 Furthermore, the percentages of IL-17-producing CD4+ T cells and IFN-gamma-producing CD8+ T cells were significantly higher in patients with AAV than in HCs (p = 0.014, p = 0.008). CHEMBL2031461 141-144 interferon gamma Homo sapiens 65-74 33537800-12 2021 IL-6, TNF-alpha, NF-kappaB and IFN-gamma levels were negatively correlated with miR-125b expression, and were inhibited by miR-125b in PBMCs. mir-125b 80-88 interferon gamma Homo sapiens 31-40 33537800-14 2021 RAF1 reversed the role of miR-125b in attenuating IL-6, TNF-alpha, NF-kappaB and IFN-gamma levels in PBMCs. mir-125b 26-34 interferon gamma Homo sapiens 81-90 33537800-16 2021 Thus, it was suggested that miR-125b served important roles in the occurrence and development of TB by decreasing the levels of IL-6, TNF-alpha, NF-kappaB and IFN-gamma by inhibiting RAF1. mir-125b 28-36 interferon gamma Homo sapiens 159-168 33504955-8 2021 Responders to minocycline had higher baseline IL-6 concentrations than non-responders (p = 0.03); IFNgamma was significantly reduced after treatment with minocycline compared with placebo (p = 0.03). Minocycline 154-165 interferon gamma Homo sapiens 98-106 33484058-5 2021 Eltrombopag, a small-molecule agonist of c-MPL, acts at a different binding site to IFN-gamma and is thus able to circumvent its inhibitory effects. eltrombopag 0-11 interferon gamma Homo sapiens 84-93 33583308-2 2021 We aimed to investigate the interferon gamma-related biomarkers neopterin and kynurenine-tryptophanratio (KT-ratio) in PSC. Neopterin 64-73 interferon gamma Homo sapiens 28-44 33583308-2 2021 We aimed to investigate the interferon gamma-related biomarkers neopterin and kynurenine-tryptophanratio (KT-ratio) in PSC. Kynurenine 78-88 interferon gamma Homo sapiens 28-44 33583308-9 2021 CONCLUSIONS: Neopterin and KT-ratio were elevated in PSC and associated with liver transplantation-free survival in two independent PSC cohorts, highlighting a possible role of interferon gamma-driven inflammation in the pathogenesis. Neopterin 13-22 interferon gamma Homo sapiens 177-193 32924886-2 2021 Neopterin, a metabolite of guanosine triphosphate, is produced by interferon-gamma-activated macrophages and is expressed at high levels in atheromatous plaques within the human carotid and coronary arteries as well as in the aorta. Neopterin 0-9 interferon gamma Homo sapiens 66-82 32924886-2 2021 Neopterin, a metabolite of guanosine triphosphate, is produced by interferon-gamma-activated macrophages and is expressed at high levels in atheromatous plaques within the human carotid and coronary arteries as well as in the aorta. Guanosine Triphosphate 27-49 interferon gamma Homo sapiens 66-82 33220334-5 2021 Importantly, the administration of mt-EVs elicited cytotoxic T cells with increasing in IFNgamma and Granzyme B production ability. mt-evs 35-41 interferon gamma Homo sapiens 88-96 33880383-10 2021 Increased levels of IFN-gamma were observed in animals treated with BUT-SNEDDS gel or butenafine. but-snedds gel 68-82 interferon gamma Homo sapiens 20-29 33880383-10 2021 Increased levels of IFN-gamma were observed in animals treated with BUT-SNEDDS gel or butenafine. butenafine 86-96 interferon gamma Homo sapiens 20-29 33859711-11 2021 In the TNF-alpha/IFN-gamma- (TI-) stimulated HaCaT cells, GGDE decreased the thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) production significantly by inhibiting p-STAT1 and NF-kappaB signaling. ggde 58-62 interferon gamma Homo sapiens 17-26 33854984-0 2021 Staphylococcus aureus beta-Hemolysin Up-Regulates the Expression of IFN-gamma by Human CD56bright NK Cells. beta-hemolysin 22-36 interferon gamma Homo sapiens 68-77 33854984-5 2021 Either blocking calcium or specifically inhibiting phosphorylation of ERK1/2 decreased the production of IFN-gamma induced by Hlb. Calcium 16-23 interferon gamma Homo sapiens 105-114 33785385-11 2022 The IHC analysis showed a higher level of Interferon gamma in the resected specimens of patients responding to imiquimod (p = 0.04). Imiquimod 111-120 interferon gamma Homo sapiens 42-58 33382900-7 2021 In vitro experiments showed that 5alpha-dihydrotestosterone (DHT) enhanced androgen receptor, TLR4, IRF-7, and p-NFkappaB p65 protein expression along with increased IFNalpha and IFNgamma abundance. Dihydrotestosterone 33-59 interferon gamma Homo sapiens 179-187 33382900-7 2021 In vitro experiments showed that 5alpha-dihydrotestosterone (DHT) enhanced androgen receptor, TLR4, IRF-7, and p-NFkappaB p65 protein expression along with increased IFNalpha and IFNgamma abundance. Dihydrotestosterone 61-64 interferon gamma Homo sapiens 179-187 33828558-11 2021 After 10 weeks of TB treatment, there was reversion in the observed functional impairment in total MAIT cells, with increases in CD107a (p = 0.020) and IFNgamma (p = 0.010) expression. Terbium 18-20 interferon gamma Homo sapiens 152-160 33744856-4 2021 T-SPOT.TB was used to detect the number of cells secreting Interferon gamma. Terbium 7-9 interferon gamma Homo sapiens 59-75 33869073-9 2021 After anti-TB treatment, IFN-gamma responses to the MTBK antigen were significantly reduced, and strong TNF-alpha responses at diagnosis were dramatically decreased. Terbium 11-13 interferon gamma Homo sapiens 25-34 33796403-7 2021 MF-766 reversed the inhibition of IFN-gamma in CD8+ T-cells by PGE2 and impaired suppression of CD8+ T-cells induced by myeloid-derived suppressor cells (MDSC)/PGE2. MF-766 0-6 interferon gamma Homo sapiens 34-43 33796403-7 2021 MF-766 reversed the inhibition of IFN-gamma in CD8+ T-cells by PGE2 and impaired suppression of CD8+ T-cells induced by myeloid-derived suppressor cells (MDSC)/PGE2. Dinoprostone 63-67 interferon gamma Homo sapiens 34-43 33796403-8 2021 In translational studies using primary human tumors, MF-766 enhanced anti-CD3-stimulated IFN-gamma, IL-2, and TNF-alpha production in primary histoculture and synergized with pembrolizumab in a PGE2 high TME. MF-766 53-59 interferon gamma Homo sapiens 89-98 33722583-7 2021 TAK-101 induced an 88% reduction in change from baseline in IFN-gamma spot-forming units versus placebo (2.01 vs 17.58, P=.006). tak-101 0-7 interferon gamma Homo sapiens 60-69 33796106-6 2021 In general, males showed higher interferon-gamma responses to TB antigens ESAT-6 and CFP-10, whilst females had stronger tuberculin responses in those with sputum smear- and culture-positive tuberculosis, but smaller responses in those who were screened for tuberculosis and who did not develop disease. Terbium 62-64 interferon gamma Homo sapiens 32-48 33791306-0 2021 Low-Dose Decitabine Augments the Activation and Anti-Tumor Immune Response of IFN-gamma+ CD4+ T Cells Through Enhancing IkappaBalpha Degradation and NF-kappaB Activation. Decitabine 9-19 interferon gamma Homo sapiens 78-87 33791306-7 2021 Results: Low-dose decitabine treatment promoted the proliferation and activation of sorted CD4+ T cells, with increased frequency of IFN-gamma+ Th1 subset and enhanced cytolytic activity in vitro and in vivo. Decitabine 18-28 interferon gamma Homo sapiens 133-142 33791306-8 2021 NF-kappaB inhibitor, BAY 11-7082, suppressed decitabine-induced CD4+ T cell proliferation and IFN-gamma production. 3-(4-methylphenylsulfonyl)-2-propenenitrile 21-32 interferon gamma Homo sapiens 94-103 33791306-8 2021 NF-kappaB inhibitor, BAY 11-7082, suppressed decitabine-induced CD4+ T cell proliferation and IFN-gamma production. Decitabine 45-55 interferon gamma Homo sapiens 94-103 33791306-11 2021 Conclusion: These data suggest that low-dose decitabine potentiates CD4+ T cell anti-tumor immunity through enhancing IkappaBalpha degradation and therefore NF-kappaB activation and IFN-gamma production. Decitabine 45-55 interferon gamma Homo sapiens 182-191 33790886-6 2021 Alternatively, combining CFP-10-induced TNF-alpha and IP-10 with heparin-binding haemagglutinin (HBHA)-induced-IFN-gamma was more effective in testing recently BCG-vaccinated children or those suspected to be infected with non-tuberculous mycobacteria, providing a correct classification of 97% of the M. tuberculosis-infected children. Heparin 65-72 interferon gamma Homo sapiens 111-120 33547171-0 2021 Functional Analysis of Immune Signature Genes in Th1* Memory Cells Links ISOC1 and Pyrimidine Metabolism to IFN-gamma and IL-17 Production. pyrimidine 83-93 interferon gamma Homo sapiens 108-117 33547171-7 2021 Supplementation with extracellular pyrimidines rescued both bioenergetics and IFN-gamma production in ISOC1-deficient T cells, indicating that pyrimidine metabolism is a key driver of effector functions in CD4+ T cells and Th1* cells. Pyrimidines 35-46 interferon gamma Homo sapiens 78-87 33547171-7 2021 Supplementation with extracellular pyrimidines rescued both bioenergetics and IFN-gamma production in ISOC1-deficient T cells, indicating that pyrimidine metabolism is a key driver of effector functions in CD4+ T cells and Th1* cells. pyrimidine 35-45 interferon gamma Homo sapiens 78-87 33790966-13 2021 GSEA showed that interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription (STAT3) signaling, interferon gamma (IFN-gamma) response, angiogenesis, and coagulation were more highly enriched in the high-risk group and that oxidative phosphorylation was more highly enriched in the low-risk group. gsea 0-4 interferon gamma Homo sapiens 125-152 33710617-0 2021 Ursodeoxycholic acid impairs liver-infiltrating T cell chemotaxis through IFNgamma and CX3CL1 production in primary biliary cholangitis. Ursodeoxycholic Acid 0-20 interferon gamma Homo sapiens 74-82 33710617-3 2021 Therefore, we examined the effects of UDCA on the expression of IFNgamma and CX3CL1 in in vitro and in vivo PBC models such as human liver tissue, a murine model, cell lines, and isolated human intrahepatic biliary epithelial cells (IHBECs). Ursodeoxycholic Acid 38-42 interferon gamma Homo sapiens 64-72 33710617-4 2021 We observed a significant decrease in IFNgamma mRNA levels and positive correlations between IFNgamma and CX3CL1 mRNA levels post-UDCA treatment in PBC livers. Ursodeoxycholic Acid 130-134 interferon gamma Homo sapiens 38-46 33710617-4 2021 We observed a significant decrease in IFNgamma mRNA levels and positive correlations between IFNgamma and CX3CL1 mRNA levels post-UDCA treatment in PBC livers. Ursodeoxycholic Acid 130-134 interferon gamma Homo sapiens 93-101 33710617-7 2021 IFNgamma significantly and dose-dependently induced CX3CL1 expression, which was significantly decreased in HuCC-T1 cells and IHBECs upon UDCA treatment. Ursodeoxycholic Acid 138-142 interferon gamma Homo sapiens 0-8 33710617-8 2021 These results suggest that UDCA-induced suppression of IFNgamma and CX3CL1 production attenuates the chemotactic and adhesive abilities of liver-infiltrating T cells in PBC. Ursodeoxycholic Acid 27-31 interferon gamma Homo sapiens 55-63 33472827-2 2021 In this study using animals of both sexes, we investigated the role of heparan sulfate proteoglycans in the modulation of IFN-gamma signaling following demyelination. Heparitin Sulfate 71-86 interferon gamma Homo sapiens 122-131 33472827-4 2021 IFN-gamma-induced quiescence was mediated by direct signaling in OPCs as conditional genetic ablation of IFNgammaR1 (Ifngr1) in adult NG2+ OPCs completely abrogated these inhibitory effects. ng2+ 134-138 interferon gamma Homo sapiens 0-9 33472827-6 2021 We found that PI-88, a heparan sulfate mimetic, directly antagonized IFN-gamma to rescue human OPC proliferation and differentiation in vitro and blocked the IFN-gamma mediated inhibitory effects on OPC recruitment in vivo Importantly, heparanase modulation by PI-88 or OGT2155 in demyelinated lesion rescued IFN-gamma mediated axonal damage and demyelination. phosphomannopentaose sulfate 14-19 interferon gamma Homo sapiens 69-78 33472827-6 2021 We found that PI-88, a heparan sulfate mimetic, directly antagonized IFN-gamma to rescue human OPC proliferation and differentiation in vitro and blocked the IFN-gamma mediated inhibitory effects on OPC recruitment in vivo Importantly, heparanase modulation by PI-88 or OGT2155 in demyelinated lesion rescued IFN-gamma mediated axonal damage and demyelination. phosphomannopentaose sulfate 14-19 interferon gamma Homo sapiens 158-167 33472827-6 2021 We found that PI-88, a heparan sulfate mimetic, directly antagonized IFN-gamma to rescue human OPC proliferation and differentiation in vitro and blocked the IFN-gamma mediated inhibitory effects on OPC recruitment in vivo Importantly, heparanase modulation by PI-88 or OGT2155 in demyelinated lesion rescued IFN-gamma mediated axonal damage and demyelination. phosphomannopentaose sulfate 14-19 interferon gamma Homo sapiens 158-167 33472827-6 2021 We found that PI-88, a heparan sulfate mimetic, directly antagonized IFN-gamma to rescue human OPC proliferation and differentiation in vitro and blocked the IFN-gamma mediated inhibitory effects on OPC recruitment in vivo Importantly, heparanase modulation by PI-88 or OGT2155 in demyelinated lesion rescued IFN-gamma mediated axonal damage and demyelination. Heparitin Sulfate 23-38 interferon gamma Homo sapiens 69-78 33472827-6 2021 We found that PI-88, a heparan sulfate mimetic, directly antagonized IFN-gamma to rescue human OPC proliferation and differentiation in vitro and blocked the IFN-gamma mediated inhibitory effects on OPC recruitment in vivo Importantly, heparanase modulation by PI-88 or OGT2155 in demyelinated lesion rescued IFN-gamma mediated axonal damage and demyelination. phosphomannopentaose sulfate 261-266 interferon gamma Homo sapiens 69-78 33472827-13 2021 We find that pathological interferon-gamma can be blocked by modulation of the heparanome following demyelination using either a heparan mimetic or by treatment with heparanase inhibitor. heparan 79-86 interferon gamma Homo sapiens 26-42 33727792-10 2021 Pretreatment of T cells with nintedanib reduced cluster formation as a marker of activation and inhibited the release of IFN-gamma, IL-2, IL-4, IL-5, IL-10, IL-12p70 and IL-13 at clinically relevant concentrations ranging from 5-77 nmol/L. nintedanib 29-39 interferon gamma Homo sapiens 121-130 33660144-9 2021 Significantly, incubation with IFN-gamma on a human cardiomyocyte line treated with an inhibitor of dihydroorotate dehydrogenase brequinar (enzyme showing a loss-of-function variant in one family) markedly reduced mitochondrial membrane potential (DeltapsiM), indicating mitochondrial dysfunction. 4,5-dihydroorotic acid 100-114 interferon gamma Homo sapiens 31-40 33655586-14 2021 By adding a STAT1 agonist IFN-gamma, the effects of AZM on inflammation, oxidative stress, and apoptosis of high glucose-induced podocytes were inhibited (p < .05). Azithromycin 52-55 interferon gamma Homo sapiens 26-35 33655586-14 2021 By adding a STAT1 agonist IFN-gamma, the effects of AZM on inflammation, oxidative stress, and apoptosis of high glucose-induced podocytes were inhibited (p < .05). Glucose 113-120 interferon gamma Homo sapiens 26-35 33653884-13 2021 This study shows that one such secreted protein, ROP16, enables efficient parasite growth and survival by suppressing IFN-gamma-independent production of ROS by human and mouse cells. Reactive Oxygen Species 154-157 interferon gamma Homo sapiens 118-127 33785718-11 2021 The upregulation of IFN-gamma by melanin, cisplatin, and their combination was demonstrated (4.3; 6.7; and 2-fold increase, respectively). Melanins 33-40 interferon gamma Homo sapiens 20-29 33785718-11 2021 The upregulation of IFN-gamma by melanin, cisplatin, and their combination was demonstrated (4.3; 6.7; and 2-fold increase, respectively). Cisplatin 42-51 interferon gamma Homo sapiens 20-29 33853687-8 2021 Mechanistically, we identified that CsA reduces SOCS1 expression to facilitate enhanced IDO production in IFNgamma pre-stimulated MSCs. Cyclosporine 36-39 interferon gamma Homo sapiens 106-114 33853687-9 2021 Importantly, CsA exposure to IFNgamma pre-stimulated MSC before administration, significantly enhanced the potency of MSCs in a human relevant humanised mouse model of acute Graft versus Host Disease. Cyclosporine 13-16 interferon gamma Homo sapiens 29-37 33131052-5 2021 While zoledronate induced mRNA expressions of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and interferon-gamma (IFN-gamma) in PBMC, depletion of gammadelta T cells abolished that zoledronate-induced expression of those cytokines, indicating the necessity of gammadelta T cells for expression induction by zoledronate. Zoledronic Acid 6-17 interferon gamma Homo sapiens 121-137 33131052-5 2021 While zoledronate induced mRNA expressions of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and interferon-gamma (IFN-gamma) in PBMC, depletion of gammadelta T cells abolished that zoledronate-induced expression of those cytokines, indicating the necessity of gammadelta T cells for expression induction by zoledronate. Zoledronic Acid 6-17 interferon gamma Homo sapiens 139-148 33131052-7 2021 Since it is generally accepted that monocytes and macrophages are primary sources of inflammatory cytokines, CD14+ cells from PBMC were exposed to zoledronate in the presence of PBMC, which resulted in induced expression of mRNAs for IL-1beta, IL-6, and IFN-gamma, but not for TNF-alpha. Zoledronic Acid 147-158 interferon gamma Homo sapiens 254-263 33131052-8 2021 These results indicate that CD14+ cells are responsible, at least in part, for the production of IL-1beta, IL-6, and IFN-gamma in blood exposed to zoledronate. Zoledronic Acid 147-158 interferon gamma Homo sapiens 117-126 33491334-0 2021 Tofacitinib overcomes an IFNgamma-induced decrease in NK cell-mediated cytotoxicity via the regulation of immune-related molecules in LC-2/ad. tofacitinib 0-11 interferon gamma Homo sapiens 25-33 32860465-3 2021 Neopterin produced by macrophages on stimulation with interferon-gamma, which is an important cytokine in the anti-viral immune response, hence it can be used to predict the severity of disease in COVID-19 cases. Neopterin 0-9 interferon gamma Homo sapiens 54-70 33668814-7 2021 In addition, polyphenols cause immunomodulatory effects against allergic reaction and autoimmune disease by inhibition of autoimmune T cell proliferation and downregulation of pro-inflammatory cytokines (interleukin-6 (IL-6), IL-1, interferon-gamma (IFN-gamma)). Polyphenols 13-24 interferon gamma Homo sapiens 232-248 33668814-7 2021 In addition, polyphenols cause immunomodulatory effects against allergic reaction and autoimmune disease by inhibition of autoimmune T cell proliferation and downregulation of pro-inflammatory cytokines (interleukin-6 (IL-6), IL-1, interferon-gamma (IFN-gamma)). Polyphenols 13-24 interferon gamma Homo sapiens 250-259 33577301-2 2021 It can not only generate reactive oxygen species (ROS) to cause the chemical damage of tumor cells in the presence of enough oxygen but also promote the antitumor immunity of T cells through enhancing the production of interferon gamma (IFN-gamma). Reactive Oxygen Species 25-48 interferon gamma Homo sapiens 219-246 33717049-10 2020 DMPA-using non-sex workers also had an increased level of plasma interferon gamma (IFN-gamma), monokine induced by interferon-gamma (MIG) and sCD40L, alongside higher proportion of CD4+CD38+ and CD4+CD69+ T cells at the cervix compared to non-sex workers no-HC controls., Finally, non-sex workers and FSWs using DMPA had similar levels of genital and peripheral CD4+ T cell activation and inflammation. N,N-dimethyl-4-anisidine 0-4 interferon gamma Homo sapiens 65-92 33602823-5 2021 Moreover, we found that two distinct DNA damaging drugs, the platinoid oxaliplatin and the topoisomerase inhibitor mitoxantrone, strongly up-regulate MHC-I AgPP in a manner dependent on activation of nuclear factor kappa B (NF-kappaB), p300/CBP, and other transcription factors, but independently of autocrine IFNgamma signaling. Oxaliplatin 71-82 interferon gamma Homo sapiens 310-318 33602823-5 2021 Moreover, we found that two distinct DNA damaging drugs, the platinoid oxaliplatin and the topoisomerase inhibitor mitoxantrone, strongly up-regulate MHC-I AgPP in a manner dependent on activation of nuclear factor kappa B (NF-kappaB), p300/CBP, and other transcription factors, but independently of autocrine IFNgamma signaling. Mitoxantrone 115-127 interferon gamma Homo sapiens 310-318 33716989-10 2021 Vitamin D deficiency was associated with decreased CD80 and IFN-gamma in PCOS and IL-12 in both groups (p<0.05). Vitamin D 0-9 interferon gamma Homo sapiens 60-69 33623012-5 2021 Using TCB and CARs directed against HER2, here we show that disruption of interferon-gamma signaling confers resistance to killing by active T lymphocytes. tcb 6-9 interferon gamma Homo sapiens 74-90 33669901-4 2021 ND islet cells were exposed to interleukin-1beta and interferon-gamma for up to 120 h. In T1D islets, we confirmed an increased prevalence of Ins+/Glu+ cells. Glutamic Acid 147-150 interferon gamma Homo sapiens 53-69 33491334-6 2021 IFNgamma-induced PD-L1, but not EGF-induced PD-L1, was clearly blocked by the JAK-STAT inhibitor tofacitinib. tofacitinib 97-108 interferon gamma Homo sapiens 0-8 33491334-8 2021 Finally, we showed that IFNgamma stimuli attenuated NK cell-mediated cytotoxicity in LC-2/ad cells, which was, however, blocked by tofacitinib. tofacitinib 131-142 interferon gamma Homo sapiens 24-32 33491334-9 2021 CONCLUSIONS: Taken together, our study shows that tofacitinib blocks the IFNgamma-induced transformation from an NK cell-sensitive phenotype to an NK cell-resistant one in IFNgamma-reacted LC-2/ad cells, thereby implicating that tofacitinib may be a promising agent to overcome IFNgamma-induced tumor immune escape, although it may be adapted to the limited number of NSCLC patients. tofacitinib 50-61 interferon gamma Homo sapiens 73-81 33491334-9 2021 CONCLUSIONS: Taken together, our study shows that tofacitinib blocks the IFNgamma-induced transformation from an NK cell-sensitive phenotype to an NK cell-resistant one in IFNgamma-reacted LC-2/ad cells, thereby implicating that tofacitinib may be a promising agent to overcome IFNgamma-induced tumor immune escape, although it may be adapted to the limited number of NSCLC patients. tofacitinib 50-61 interferon gamma Homo sapiens 172-180 33491334-9 2021 CONCLUSIONS: Taken together, our study shows that tofacitinib blocks the IFNgamma-induced transformation from an NK cell-sensitive phenotype to an NK cell-resistant one in IFNgamma-reacted LC-2/ad cells, thereby implicating that tofacitinib may be a promising agent to overcome IFNgamma-induced tumor immune escape, although it may be adapted to the limited number of NSCLC patients. tofacitinib 50-61 interferon gamma Homo sapiens 172-180 33491334-9 2021 CONCLUSIONS: Taken together, our study shows that tofacitinib blocks the IFNgamma-induced transformation from an NK cell-sensitive phenotype to an NK cell-resistant one in IFNgamma-reacted LC-2/ad cells, thereby implicating that tofacitinib may be a promising agent to overcome IFNgamma-induced tumor immune escape, although it may be adapted to the limited number of NSCLC patients. tofacitinib 229-240 interferon gamma Homo sapiens 73-81 33598892-0 2022 Effects of Supplemental Chromium Nanoparticles on IFN-gamma expression of Heat Stress Broilers. Chromium 24-32 interferon gamma Homo sapiens 50-59 33357846-4 2021 However, the treatment of SP and SP-FA enhance the NK cells cytotoxicity against HeLa cells by the upregulation of IFN-gamma, TNF-alpha, perforin, and Granzyme-B. sp 26-28 interferon gamma Homo sapiens 115-124 32898857-8 2021 However, the addition of dasatinib or ponatinib inhibited T-cell proliferation and IFN-gamma production. Dasatinib 25-34 interferon gamma Homo sapiens 83-92 32898857-8 2021 However, the addition of dasatinib or ponatinib inhibited T-cell proliferation and IFN-gamma production. ponatinib 38-47 interferon gamma Homo sapiens 83-92 33580472-0 2021 Altered IFN-gamma Levels after Treatment of Epileptic Patients with Omega-3 Fatty Acids. Fatty Acids, Omega-3 68-87 interferon gamma Homo sapiens 8-17 33603036-4 2021 Exposure to fine particular matter (PM2.5), carbon monoxide (CO), and ozone (O3) was linked to altered methylation of most CpG sites for genes Foxp3, IL-4, IL-10 and IFN-g, all involved in immune regulation (e.g. higher PM2.5 exposure 1 month prior to the study visit was independently associated with methylation of the IL-4 CpG24 site (est = 0.16; P = 0.0095). Carbon Monoxide 44-59 interferon gamma Homo sapiens 166-171 33603036-4 2021 Exposure to fine particular matter (PM2.5), carbon monoxide (CO), and ozone (O3) was linked to altered methylation of most CpG sites for genes Foxp3, IL-4, IL-10 and IFN-g, all involved in immune regulation (e.g. higher PM2.5 exposure 1 month prior to the study visit was independently associated with methylation of the IL-4 CpG24 site (est = 0.16; P = 0.0095). Carbon Monoxide 61-63 interferon gamma Homo sapiens 166-171 33603036-4 2021 Exposure to fine particular matter (PM2.5), carbon monoxide (CO), and ozone (O3) was linked to altered methylation of most CpG sites for genes Foxp3, IL-4, IL-10 and IFN-g, all involved in immune regulation (e.g. higher PM2.5 exposure 1 month prior to the study visit was independently associated with methylation of the IL-4 CpG24 site (est = 0.16; P = 0.0095). Ozone 70-75 interferon gamma Homo sapiens 166-171 33357846-4 2021 However, the treatment of SP and SP-FA enhance the NK cells cytotoxicity against HeLa cells by the upregulation of IFN-gamma, TNF-alpha, perforin, and Granzyme-B. sp-fa 33-38 interferon gamma Homo sapiens 115-124 33559345-9 2021 Human renal cells treated with CPT or TPT had reduced expression of Fli-1 and decreased MCP1 following stimulation with IFN-alpha or IFN-gamma. Topotecan 38-41 interferon gamma Homo sapiens 133-142 33580429-4 2021 During ex vivo T cell activation, the addition of excess sodium lactate (NaL) increased the production of cytokines (such as IFNgamma/IL-2/TNFalpha) more than the addition of sodium chloride (NaCl). Sodium Lactate 57-71 interferon gamma Homo sapiens 125-133 33580429-4 2021 During ex vivo T cell activation, the addition of excess sodium lactate (NaL) increased the production of cytokines (such as IFNgamma/IL-2/TNFalpha) more than the addition of sodium chloride (NaCl). acetylleucine 73-76 interferon gamma Homo sapiens 125-133 34027274-6 2021 We found that HI of DAP recruited conventional NK cells (cNK) into the liver and promoted tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) production of NK cells in a chemokine (C-X-C motif) receptor 3 (CXCR3)-dependent manner. dap 20-23 interferon gamma Homo sapiens 134-150 33557291-9 2021 Solely in the open surgery group, cortisol dynamics paralleled changes in interleukin (IL)-1beta, IL-10, IL-1ra, IL-7, IL-8 and tumor necrosis factor (TNF)-alpha but did not correlate with changes in IL-6 or interferon (IFN)-gamma at any time-point. Hydrocortisone 34-42 interferon gamma Homo sapiens 208-230 34027274-6 2021 We found that HI of DAP recruited conventional NK cells (cNK) into the liver and promoted tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) production of NK cells in a chemokine (C-X-C motif) receptor 3 (CXCR3)-dependent manner. dap 20-23 interferon gamma Homo sapiens 152-161 33564258-5 2021 Neopterin is a macrophage activation marker produced by monocytes and macrophages upon activation by interferon-gamma (IFN-gamma). Neopterin 0-9 interferon gamma Homo sapiens 101-117 33539379-8 2021 The IND group showed, at 9-12 months after treatment, an increase in the CD4+ T cell subset coproducing three molecules, which were mainly granzyme B+, perforin+ and IFN-gamma+ (1.4% versus 4.5%). indole 4-7 interferon gamma Homo sapiens 166-175 33497523-7 2021 Treating young and old murine and human CD4+ T cells with 6-diazo-5-oxo-l-norleucine (DON), a glutaminolysis inhibitor resulted in significantly reduced IFN-gamma production and compromised proliferative capacities specifically of old CD4+ T cells. Diazooxonorleucine 58-84 interferon gamma Homo sapiens 153-162 33497523-7 2021 Treating young and old murine and human CD4+ T cells with 6-diazo-5-oxo-l-norleucine (DON), a glutaminolysis inhibitor resulted in significantly reduced IFN-gamma production and compromised proliferative capacities specifically of old CD4+ T cells. Diazooxonorleucine 86-89 interferon gamma Homo sapiens 153-162 33564258-5 2021 Neopterin is a macrophage activation marker produced by monocytes and macrophages upon activation by interferon-gamma (IFN-gamma). Neopterin 0-9 interferon gamma Homo sapiens 119-128 33598569-6 2021 TB prevention in silicosis patients is essential and include active surveillance of the workers, periodic chest X-rays, tuberculin skin test or interferon-gamma releasing assay testing, and, importantly, adoption of measures to reduce the exposure to silica dust. Terbium 0-2 interferon gamma Homo sapiens 144-160 33007334-5 2021 Moreover, the IFP35 gene was significantly induced in vivo for 120 h following the infection of infectious spleen and kidney necrosis virus (ISKNV), and its mRNA and protein level was also significantly induced in vitro following the treatment of poly I:C, IFNh, IFNc, as well as IFN-gamma. Poly I 247-253 interferon gamma Homo sapiens 280-289 32772240-0 2021 Inhibition of JAK-STAT Signaling by Baricitinib Reduces Interferon-gamma-Induced CXCL10 Production in Human Salivary Gland Ductal Cells. baricitinib 36-47 interferon gamma Homo sapiens 56-72 33341671-12 2021 Lip-Ful was also found to induce secretion of pro-inflammatory TNF-alpha, IFN-gamma and IL-1beta cytokines. lip-ful 0-7 interferon gamma Homo sapiens 74-83 33325128-8 2021 After the DPCP treatment, TSLP, IL-5 and IL-13 increased and IFN-gamma decreased in responders while there were no changes of TSLP, IL-4, IL-13 and IFN-gamma in non-responders. diphenylcyclopropenone 10-14 interferon gamma Homo sapiens 61-70 33352218-6 2021 Consistently, alphaT and gammaT mitigated TNF-alpha/IFN-gamma-induced impairment of trans-epithelial electrical resistance in human intestinal epithelial Caco-2 cell monolayer. alpha-Tocopherol 14-20 interferon gamma Homo sapiens 52-61 33352218-6 2021 Consistently, alphaT and gammaT mitigated TNF-alpha/IFN-gamma-induced impairment of trans-epithelial electrical resistance in human intestinal epithelial Caco-2 cell monolayer. gammat 25-31 interferon gamma Homo sapiens 52-61 33333254-7 2021 The mean reduction rates at 7-10 days after treatment for serum interleukin-6 and interferon-gamma concentrations were greater in the thalidomide group compared to the controls. Thalidomide 134-145 interferon gamma Homo sapiens 82-98 33334656-10 2021 RESULTS: IL-17A blocked the suppressive function of Tregs, possibly by inhibiting the release of TGF-beta and promoting the production of IFN-gamma. tregs 52-57 interferon gamma Homo sapiens 138-147 32772240-4 2021 We investigated the effects of baricitinib, a selective JAK1/2 inhibitor, on both IFN-gamma-induced CXCL10 production and immune-cell chemotaxis. baricitinib 31-42 interferon gamma Homo sapiens 82-91 32772240-8 2021 Baricitinib significantly inhibited IFN-gamma-induced CXCL10 expression as well as the protein levels in an immortalized human salivary gland ductal-cell clone in a dose-dependent manner. baricitinib 0-11 interferon gamma Homo sapiens 36-45 32772240-9 2021 Additionally, western blot analysis showed that baricitinib suppressed the IFN-gamma-induced phosphorylation of STAT1 and STAT3, with a stronger effect observed in the case of STAT1. baricitinib 48-59 interferon gamma Homo sapiens 75-84 32772240-11 2021 These results suggested that baricitinib suppressed IFN-gamma-induced CXCL10 expression and attenuated immune-cell chemotaxis by inhibiting JAK/STAT signaling, suggesting its potential as a therapeutic strategy for pSS. baricitinib 29-40 interferon gamma Homo sapiens 52-61 33558721-5 2021 High tumor mutational burden (TMB) and high interferon-gamma-related gene expression signature score (IFN-gamma score) were associated with pathologic response and low risk of relapse; pRR was 100% in patients with high IFN-gamma score/high TMB; patients with high IFN-gamma score/low TMB or low IFN-gamma score/high TMB had pRRs of 91% and 88%; while patients with low IFN-gamma score/low TMB had a pRR of only 39%. 1,2,4,5-tetramethoxybenzene 241-244 interferon gamma Homo sapiens 102-111 33317956-9 2021 Treatment with prednisolone + theophylline + cyclosporin A inhibited IFN-gamma and TNF-alpha production by SA CD28null CD8+ T and NKT-like cells additively. Prednisolone 15-27 interferon gamma Homo sapiens 69-78 33317956-9 2021 Treatment with prednisolone + theophylline + cyclosporin A inhibited IFN-gamma and TNF-alpha production by SA CD28null CD8+ T and NKT-like cells additively. Theophylline 30-42 interferon gamma Homo sapiens 69-78 33317956-9 2021 Treatment with prednisolone + theophylline + cyclosporin A inhibited IFN-gamma and TNF-alpha production by SA CD28null CD8+ T and NKT-like cells additively. Cyclosporine 45-58 interferon gamma Homo sapiens 69-78 33317956-9 2021 Treatment with prednisolone + theophylline + cyclosporin A inhibited IFN-gamma and TNF-alpha production by SA CD28null CD8+ T and NKT-like cells additively. sa 107-109 interferon gamma Homo sapiens 69-78 33278400-7 2021 Rv2628 and Rv1733 restimulation induced significantly higher IFNgamma, IP-10, and IL-22 concentrations in ACs. rv2628 0-6 interferon gamma Homo sapiens 61-69 33278400-7 2021 Rv2628 and Rv1733 restimulation induced significantly higher IFNgamma, IP-10, and IL-22 concentrations in ACs. rv1733 11-17 interferon gamma Homo sapiens 61-69 33278400-8 2021 Combined antigen/cytokine analyses identified study group specific patterns and a combination of Rv2628/Rv1733 induced IFNgamma with IGRA-antigen induced IL-6 was optimal for classification of tuberculosis patients and ACs (AUC: 0.92, p<0.0001). rv2628 97-103 interferon gamma Homo sapiens 119-127 33278400-8 2021 Combined antigen/cytokine analyses identified study group specific patterns and a combination of Rv2628/Rv1733 induced IFNgamma with IGRA-antigen induced IL-6 was optimal for classification of tuberculosis patients and ACs (AUC: 0.92, p<0.0001). rv1733 104-110 interferon gamma Homo sapiens 119-127 33395584-6 2021 PEG-IFN was added and cells were incubated for additional 24 h. Co-cultured cells incubated with the association (SHDAg + PEG-IFN) significantly produced levels of IFN-gamma, IL-2 and IL-12. peg-ifn 0-7 interferon gamma Homo sapiens 164-173 33395584-6 2021 PEG-IFN was added and cells were incubated for additional 24 h. Co-cultured cells incubated with the association (SHDAg + PEG-IFN) significantly produced levels of IFN-gamma, IL-2 and IL-12. shdag 114-119 interferon gamma Homo sapiens 164-173 33395584-6 2021 PEG-IFN was added and cells were incubated for additional 24 h. Co-cultured cells incubated with the association (SHDAg + PEG-IFN) significantly produced levels of IFN-gamma, IL-2 and IL-12. peg-ifn 122-129 interferon gamma Homo sapiens 164-173 33395584-7 2021 On the other hand, the HBsAg alone was able to inhibit the production of IFN-gamma, suggesting that this antigen may hinder the treatment exclusively with PEG-IFN. peg-ifn 155-162 interferon gamma Homo sapiens 73-82 33328638-11 2021 Together, our results suggest that IDO1-mediated depletion of tryptophan, which is induced by IFNgamma, has a role in the immune recognition of melanoma cells by contributing to diversification of the peptidome landscape. Tryptophan 62-72 interferon gamma Homo sapiens 94-102 33558721-5 2021 High tumor mutational burden (TMB) and high interferon-gamma-related gene expression signature score (IFN-gamma score) were associated with pathologic response and low risk of relapse; pRR was 100% in patients with high IFN-gamma score/high TMB; patients with high IFN-gamma score/low TMB or low IFN-gamma score/high TMB had pRRs of 91% and 88%; while patients with low IFN-gamma score/low TMB had a pRR of only 39%. 1,2,4,5-tetramethoxybenzene 241-244 interferon gamma Homo sapiens 102-111 33558721-5 2021 High tumor mutational burden (TMB) and high interferon-gamma-related gene expression signature score (IFN-gamma score) were associated with pathologic response and low risk of relapse; pRR was 100% in patients with high IFN-gamma score/high TMB; patients with high IFN-gamma score/low TMB or low IFN-gamma score/high TMB had pRRs of 91% and 88%; while patients with low IFN-gamma score/low TMB had a pRR of only 39%. 1,2,4,5-tetramethoxybenzene 241-244 interferon gamma Homo sapiens 102-111 33558721-5 2021 High tumor mutational burden (TMB) and high interferon-gamma-related gene expression signature score (IFN-gamma score) were associated with pathologic response and low risk of relapse; pRR was 100% in patients with high IFN-gamma score/high TMB; patients with high IFN-gamma score/low TMB or low IFN-gamma score/high TMB had pRRs of 91% and 88%; while patients with low IFN-gamma score/low TMB had a pRR of only 39%. 1,2,4,5-tetramethoxybenzene 241-244 interferon gamma Homo sapiens 102-111 33584591-0 2020 Low-Density Granulocytes Affect T-SPOT.TB Assay by Inhibiting the Production of Interferon-gamma in T Cells via PD-L1/PD-1 Pathway. Terbium 39-41 interferon gamma Homo sapiens 80-96 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interferon gamma Homo sapiens 263-272 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interferon gamma Homo sapiens 322-331 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interferon gamma Homo sapiens 263-272 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interferon gamma Homo sapiens 322-331 32890713-7 2021 Phytohaemagglutinin M (PHA-M) -elicited human peripheral blood mononuclear cells (PBMCs) were further applied to assess the suppressive activity of PePs on IFN-gamma and IL-17 production. peps 148-152 interferon gamma Homo sapiens 156-165 33584591-1 2020 Background: T-SPOT TB (T-SPOT) assay is widely used for detection of Mycobacterium tuberculosis infection that is based on the detection of M. tuberculosis-specific interferon-gamma-secreting T cells (ISCs) in peripheral blood mononuclear cells (PBMCs). Terbium 19-21 interferon gamma Homo sapiens 165-181 33472894-9 2022 The antibacterial IFN-gamma response of liver sinusoidal Vgamma9+Vdelta2+ T cells significantly correlated with liver function, and inversely correlated with the plasma level of D-lactate in patients with CLD. D-Lactic acid 178-187 interferon gamma Homo sapiens 18-27 33644712-3 2021 c-Abl/Arg could mediate STAT1 phosphorylation independent of Janus kinases in the absence of IFNgamma and potentiate IFNgamma-mediated STAT1 phosphorylation. Arginine 6-9 interferon gamma Homo sapiens 117-125 33614817-13 2021 Mn2+ decreased serum levels of HBsAG, increased serum levels of alanine aminotransferase (ALT), IFN-alpha and IFN-beta, and enhanced lymphocyte infiltration and the percentage of IFN-gamma-producing CD8+ T cells in the liver of AAV-HBV-infected mice. Manganese(2+) 0-4 interferon gamma Homo sapiens 179-188 33467713-7 2021 As both factors are associated with resistance to ICI therapy, we have discussed their possible involvement in HPD with the conclusion that IFN-gamma may contribute to HP onset through the activation of the inflammasome pathway, immunosuppressive enzyme IDO1 and activation-induced cell death (AICD) in effector T cells, while the role of CD38 in HP may be associated with the activation of adenosine receptors, hypoxia pathways and AICD-dependent T-cell depletion. Adenosine 391-400 interferon gamma Homo sapiens 140-149 33537033-12 2020 Collectively, our results demonstrate that low-dose 11S could improve serum immune by secreting IFN-gamma. 5-chloroindole 52-55 interferon gamma Homo sapiens 96-105 33435880-8 2021 RESULTS: We demonstrate that amygdalin treatment could rescue the HBV-T cell viability and IFN-gamma and TNF-alphaproduction. Amygdalin 29-38 interferon gamma Homo sapiens 91-100 33452311-8 2021 The anti-tumor effects of VTX-2337+ cetuximab were accompanied by increased splenic lymphoid DCs and IFNgamma+ CD4+ and tumor-specific CD8+ T cells. VTX-2337 26-34 interferon gamma Homo sapiens 101-109 33519429-4 2020 IFNgamma induced PD-L1 transcription was consistently suppressed by Lercanidipine in 24 h, whereas, the half-life of PD-L1 protein was not significantly affected. lercanidipine 68-81 interferon gamma Homo sapiens 0-8 33519429-5 2020 IFNgamma trigged significant STAT1 phosphorylation, which was eliminated by Lercanidipine. lercanidipine 76-89 interferon gamma Homo sapiens 0-8 33438988-3 2021 Neopterin is a surrogate marker for viral inflammation, and its production by macrophages is driven by interferon-gamma. Neopterin 0-9 interferon gamma Homo sapiens 103-119 33435880-11 2021 Co-culture with HBV-T cells could reduce IFN-gamma and TNF-alpha, production while increase IL-6 and IL-10 production in HepG2.2.15 cells; these alterations could be partially reversed by amygdalin pretreatment. Amygdalin 188-197 interferon gamma Homo sapiens 41-50 33445752-2 2021 The YF17DD induces polyvalent responses, with a TH1/TH2 CD4+ profile, robust T CD8+ responses, and synthesis of interferon-gamma (IFN-gamma), culminating in high titers of neutralizing antibodies. yf17dd 4-10 interferon gamma Homo sapiens 112-128 33445752-2 2021 The YF17DD induces polyvalent responses, with a TH1/TH2 CD4+ profile, robust T CD8+ responses, and synthesis of interferon-gamma (IFN-gamma), culminating in high titers of neutralizing antibodies. yf17dd 4-10 interferon gamma Homo sapiens 130-139 33445752-4 2021 Here, we conducted a follow-up study in volunteers immunized with YF17DD, investigating the humoral response, cellular phenotypes, gene expression, and single nucleotide polymorphisms (SNPs) of IFNG and CLEC5A, to clarify the role of these factors in early response after vaccination. yf17dd 66-72 interferon gamma Homo sapiens 194-198 33420659-9 2021 Consistently, stimulation of endarterectomy specimens with interferon-gamma + lipopolysaccharide decreased 14C-acetate uptake to 66.5 +- 14.5%, while interleukin-4 increased 14C-acetate uptake to 151.5 +- 25.8% compared to non-stimulated plaques (P < .05). 14c-acetate 107-118 interferon gamma Homo sapiens 59-75 33420659-9 2021 Consistently, stimulation of endarterectomy specimens with interferon-gamma + lipopolysaccharide decreased 14C-acetate uptake to 66.5 +- 14.5%, while interleukin-4 increased 14C-acetate uptake to 151.5 +- 25.8% compared to non-stimulated plaques (P < .05). 14c-acetate 174-185 interferon gamma Homo sapiens 59-75 33417619-13 2021 Lower levels of IFN-gamma, IL-6, IL-10, IL-13 and I-TAC were found in the Sp group compared with those in the Cp group. TFF2 protein, human 74-76 interferon gamma Homo sapiens 16-25 33417619-14 2021 The IFN-gamma, IL-6 and IL-10 levels were lower in the Dp group than those in the Cp group (p<0.05). Dipyridamole 55-57 interferon gamma Homo sapiens 4-13 33417619-15 2021 Meanwhile, in the Sp group, lower levels of pro-inflammatory factors IFN-gamma, IL-1beta, IL-2, IL-6, IL-7, IL-21 and TNF-alpha, in addition to higher levels of anti-inflammatory factors IL-4 and IL-5 in gingival crevicular fluid, were identified than those in the Dp group. TFF2 protein, human 18-20 interferon gamma Homo sapiens 69-78 33404106-6 2021 SM-induced cell death in M1 Mphis was mediated by apoptosis as well as necroptosis, activated both extrinsic and intrinsic pathways of apoptosis, and was attributed to the IFN-gamma-mediated differentiation. Samarium 0-2 interferon gamma Homo sapiens 172-181 33427044-4 2021 In this article, using the Respiratory Syncytial Virus (RSV) nanoparticulate prefusion F model antigen developed by Sanofi, we demonstrate in the macaque model that the polyacrylate (PAA)-based adjuvant SPA09 is well tolerated and increases vaccine antigen-specific humoral immunity (sustained neutralizing antibodies, memory B cells and mucosal immunity) and elicits strong TH1-type responses (based on IFNgamma and IL-2 ELISpots) in a dose-dependent manner. carbopol 940 169-181 interferon gamma Homo sapiens 404-412 33427044-4 2021 In this article, using the Respiratory Syncytial Virus (RSV) nanoparticulate prefusion F model antigen developed by Sanofi, we demonstrate in the macaque model that the polyacrylate (PAA)-based adjuvant SPA09 is well tolerated and increases vaccine antigen-specific humoral immunity (sustained neutralizing antibodies, memory B cells and mucosal immunity) and elicits strong TH1-type responses (based on IFNgamma and IL-2 ELISpots) in a dose-dependent manner. paa 183-186 interferon gamma Homo sapiens 404-412 33469335-5 2021 On the basis of our previous in vitro studies, in which the proinflammatory cytokines TNF-alpha and IFN-gamma strongly potentiated the toxic activity of low doses of TcdB, we hypothesize that the presence of both TcdB in the circulation and a systemic proinflammatory cytokine storm may be responsible for the selective severe effects of TcdB in some patients. trimethylaminocarboxyldihydroboran 166-170 interferon gamma Homo sapiens 100-109 33469335-5 2021 On the basis of our previous in vitro studies, in which the proinflammatory cytokines TNF-alpha and IFN-gamma strongly potentiated the toxic activity of low doses of TcdB, we hypothesize that the presence of both TcdB in the circulation and a systemic proinflammatory cytokine storm may be responsible for the selective severe effects of TcdB in some patients. trimethylaminocarboxyldihydroboran 213-217 interferon gamma Homo sapiens 100-109 33469335-5 2021 On the basis of our previous in vitro studies, in which the proinflammatory cytokines TNF-alpha and IFN-gamma strongly potentiated the toxic activity of low doses of TcdB, we hypothesize that the presence of both TcdB in the circulation and a systemic proinflammatory cytokine storm may be responsible for the selective severe effects of TcdB in some patients. trimethylaminocarboxyldihydroboran 213-217 interferon gamma Homo sapiens 100-109 33278357-3 2021 Mechanistically, TNF-alpha and IFN-gamma co-treatment activated the JAK/STAT1/IRF1 axis, inducing nitric oxide production and driving caspase-8/FADD-mediated PANoptosis. Nitric Oxide 98-110 interferon gamma Homo sapiens 31-40 33505216-6 2021 The anti-inflammatory mechanism of GL and GA is realized via cytokines like interferon-gamma, tumor necrotizing factor-alpha, interleukin- (IL-) 1beta, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, and IL-17. gl 35-37 interferon gamma Homo sapiens 76-124 33505216-6 2021 The anti-inflammatory mechanism of GL and GA is realized via cytokines like interferon-gamma, tumor necrotizing factor-alpha, interleukin- (IL-) 1beta, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, and IL-17. Glycyrrhetinic Acid 42-44 interferon gamma Homo sapiens 76-124 33191170-8 2021 Human CD8+ T cells cocultured with 2DG-PLGA-NP-treated Huh7 cells showed their increased interferon-gamma production and glucose uptake compared with the CD8+ T cells co-cultured with PLGA-NP-treated Huh7 cells. Deoxyglucose 35-38 interferon gamma Homo sapiens 89-105 33389306-6 2021 The ultrapulsed ablative fractionated CO2 laser may assist topical drug delivery, and may drive stronger local Th1 responses due to an imbalance of IFN-gamma/IL-4 expressions, suggesting that the combination of ablative fractionated CO2 laser with topical agents would be an effective option for the treatment of onychomycosis. Carbon Dioxide 38-41 interferon gamma Homo sapiens 148-157 33285108-0 2021 Overcoming interferon (IFN)-gamma resistance ameliorates transforming growth factor (TGF)-beta-mediated lung fibroblast-to-myofibroblast transition and bleomycin-induced pulmonary fibrosis. Bleomycin 152-161 interferon gamma Homo sapiens 11-33 33378962-0 2021 Triptolide suppresses oral cancer cell PD-L1 expression in the interferon-gamma-modulated microenvironment in vitro, in vivo, and in clinical patients. triptolide 0-10 interferon gamma Homo sapiens 63-79 33397312-3 2021 This study estimates diagnostic efficacy of the interferon gamma release assay (IGRA: T-SPOT.TB) in TPE patients of different characteristics. Terbium 93-95 interferon gamma Homo sapiens 48-64 32888966-3 2021 GS-9620 induced cytokine production in peripheral blood mononuclear cells (PBMCs) as well as CD80 expression in CD11c+ cells and increased CD69 and interferon (IFN)-gamma expressions in T cells. vesatolimod 0-7 interferon gamma Homo sapiens 148-170 33491413-3 2021 Currently interferon-gamma release assays (QuantiFERON-TB Gold (QFT)) have been proposed as the best screening test, especially in the geographic areas with widespread BCG vaccination. quantiferon-tb gold 43-62 interferon gamma Homo sapiens 10-26 33491413-3 2021 Currently interferon-gamma release assays (QuantiFERON-TB Gold (QFT)) have been proposed as the best screening test, especially in the geographic areas with widespread BCG vaccination. 2-fluoro-5-nitrophenol 64-67 interferon gamma Homo sapiens 10-26 33430735-8 2021 RESULTS: In HIV positive participants treated with Pidotimod, the evaluation of cytokine levels showed that IL-10, IFN gamma, and IL-4 were significantly higher at enrolment compared to the control group. pidotimod 51-60 interferon gamma Homo sapiens 115-124 32888966-7 2021 Furthermore, GS-9620 increased IFN-gamma and TNF-alpha production and inhibited syncytium formation in vitro, suggesting that GS-9620 may be used to treat BLV infection. vesatolimod 13-20 interferon gamma Homo sapiens 31-40 32469071-0 2021 Retinoic Acid Is Elevated in the Mucosa of Patients With Active Ulcerative Colitis and Displays a Proinflammatory Role by Augmenting IL-17 and IFNgamma Production. Tretinoin 0-13 interferon gamma Homo sapiens 143-151 33390854-0 2021 The IFN-gamma-IDO1-kynureine pathway-induced autophagy in cervical cancer cell promotes phagocytosis of macrophage. kynureine 19-28 interferon gamma Homo sapiens 4-13 33390854-8 2021 IFN-gamma treatment and IDO1 overexpression promoted tryptophan depletion and kynurenine accumulation in cervical cancer cells. Kynurenine 78-88 interferon gamma Homo sapiens 0-9 33658903-11 2021 Dimethyl fumarate use is associated with indeterminate QFT-GIT results, possibly due to functional effects on lymphocytes and levels of cytokines, such as interferon gamma. Dimethyl Fumarate 0-17 interferon gamma Homo sapiens 155-171 32281670-10 2021 DAA therapy restores a normal adaptive NK phenotype and enhances IFNgamma production by this cell subset. daa 0-3 interferon gamma Homo sapiens 65-73 32469071-2 2021 Our previous research highlighted that in the face of inflammatory conditions, RA plays a contrary role where it aggravates intestinal inflammation by promoting interferon (IFN) gamma and interleukin (IL)-17 differentiation in vitro. Tretinoin 79-81 interferon gamma Homo sapiens 161-183 32469071-6 2021 Moreover, the raised RA levels in patients with active disease showed a positive correlation with proinflammatory cytokines (IL-17, IFNgamma) and a negative correlation with IL-10. Tretinoin 21-23 interferon gamma Homo sapiens 132-140 32914717-0 2021 New oxazolidines inhibit the secretion of IFN-gamma and IL-17 by PBMCS from moderate to severe asthmatic patients. oxazolidine 4-16 interferon gamma Homo sapiens 42-51 32203139-6 2021 Meanwhile, NAE inhibition favorably modulates polarization of T cells in vitro, with decreased Treg differentiation and a shift toward TH1 phenotype, accompanied by increased interferon-gamma production. N-lauroylethanolamine 11-14 interferon gamma Homo sapiens 175-191 32951264-10 2021 In addition, crocin/crocetin at low concentrations caused an elevation in mRNA expression of anti-inflammatory cytokines (transforming growth factor-beta, interleukin-10 [IL-10], and IL-4), while at higher doses (25 and 50 microM) they led to lowering inflammatory cytokines (IL-1beta, IL-6, IL-17, and interferon gamma). crocin 13-19 interferon gamma Homo sapiens 303-319 32951264-10 2021 In addition, crocin/crocetin at low concentrations caused an elevation in mRNA expression of anti-inflammatory cytokines (transforming growth factor-beta, interleukin-10 [IL-10], and IL-4), while at higher doses (25 and 50 microM) they led to lowering inflammatory cytokines (IL-1beta, IL-6, IL-17, and interferon gamma). crocetin 20-28 interferon gamma Homo sapiens 303-319 32914717-3 2021 OBJECTIVE: The present study aimed to evaluate the IL-17A and IFN-gamma modulatory effect of two new oxazolidine derivatives (LPSF/NB-12 and -13) on mononucleated cells of patients with moderate and severe asthma. oxazolidine 101-112 interferon gamma Homo sapiens 62-71 32914717-3 2021 OBJECTIVE: The present study aimed to evaluate the IL-17A and IFN-gamma modulatory effect of two new oxazolidine derivatives (LPSF/NB-12 and -13) on mononucleated cells of patients with moderate and severe asthma. lpsf 126-130 interferon gamma Homo sapiens 62-71 32914717-3 2021 OBJECTIVE: The present study aimed to evaluate the IL-17A and IFN-gamma modulatory effect of two new oxazolidine derivatives (LPSF/NB-12 and -13) on mononucleated cells of patients with moderate and severe asthma. Niobium 131-133 interferon gamma Homo sapiens 62-71 33130472-0 2021 Licochalcone A inhibits interferon-gamma-induced programmed death-ligand 1 in lung cancer cells. licochalcone A 0-14 interferon gamma Homo sapiens 24-40 32294652-11 2021 RESULTS: Combined administration of vinpocetine and dexamethasone lowered the expression levels of serum inflammatory cytokines, including TLR2, TLR4, interleukin (IL)-20, IL-8, tumor necrosis factor-alpha, interferon-gamma, monocyte chemoattractant protein 2, and interferon-induced protein 20, when compared to dexamethasone monotherapy. vinpocetine 36-47 interferon gamma Homo sapiens 207-223 32294652-11 2021 RESULTS: Combined administration of vinpocetine and dexamethasone lowered the expression levels of serum inflammatory cytokines, including TLR2, TLR4, interleukin (IL)-20, IL-8, tumor necrosis factor-alpha, interferon-gamma, monocyte chemoattractant protein 2, and interferon-induced protein 20, when compared to dexamethasone monotherapy. Dexamethasone 52-65 interferon gamma Homo sapiens 207-223 33130472-15 2021 N-acetyl-L-cysteine (NAC) not only revered ROS generation triggered by LCA but also restored IFN-gamma-induced expression of PD-L1. Acetylcysteine 21-24 interferon gamma Homo sapiens 93-102 33130472-17 2021 CONCLUSION: LCA abrogated IFN-gamma-induced PD-L1 expression via ROS generation to abolish the protein translation, indicating that LCA has the potential to be applied in cancer immunotherapy. licochalcone A 12-15 interferon gamma Homo sapiens 26-35 32964394-9 2021 However, it was found that administration of LD50 dose beta-arbutin induced inflammation in these cells via proinflammatory cytokine levels (TNF-alpha, IFN-gamma and IL-1beta). Arbutin 55-67 interferon gamma Homo sapiens 152-161 32441185-5 2021 After a primary screening of 267 natural products, two hits, Astragalus polyphenols and 6-shogaol, were identified to promote the activity of the IFN-gamma promoter and subsequently validated by the flow cytometry assay. Polyphenols 72-83 interferon gamma Homo sapiens 146-155 32441185-5 2021 After a primary screening of 267 natural products, two hits, Astragalus polyphenols and 6-shogaol, were identified to promote the activity of the IFN-gamma promoter and subsequently validated by the flow cytometry assay. shogaol 88-97 interferon gamma Homo sapiens 146-155 32441185-6 2021 Obviously, both Astragalus polyphenols and 6-shogaol exhibited potential to induce the transcription and expression of IFN-gamma in a dose-dependent manner. Polyphenols 27-38 interferon gamma Homo sapiens 119-128 32441185-6 2021 Obviously, both Astragalus polyphenols and 6-shogaol exhibited potential to induce the transcription and expression of IFN-gamma in a dose-dependent manner. shogaol 43-52 interferon gamma Homo sapiens 119-128 33290779-8 2021 Treatment with 6SA increases the secretion of IL-2, IL-12, GM-CSF, TNF-alpha and IFN-gamma and significantly reduces IL-10 and IL-17 secretion, suggesting that the reduction of regulatory T cells and tumor-associated macrophages contribute to the host control of tumor development. anacardic acid 15-18 interferon gamma Homo sapiens 81-90 33074126-8 2021 Moreover, LPS/IFNgamma-induced M1-polarization showed remarkably higher expression levels of STC1 than IL-4/IL-13-induced M2-macrophages and PMA-induced M0-macrophages. Tetradecanoylphorbol Acetate 141-144 interferon gamma Homo sapiens 14-22 33130472-17 2021 CONCLUSION: LCA abrogated IFN-gamma-induced PD-L1 expression via ROS generation to abolish the protein translation, indicating that LCA has the potential to be applied in cancer immunotherapy. licochalcone A 132-135 interferon gamma Homo sapiens 26-35 33130472-5 2021 PURPOSE: The aim of this study is to further clarify the effect and the mechanism of LCA on inhibiting IFN-gamma-induced PD-L1 in lung cancer cells. licochalcone A 85-88 interferon gamma Homo sapiens 103-112 33130472-10 2021 RESULTS: LCA downregulated IFN-gamma-induced PD-L1 protein expression and membrane localization in human lung cancer cells, regardless of inhibiting PD-L1 mRNA level or promoting its protein degradation. licochalcone A 9-12 interferon gamma Homo sapiens 27-36 33130472-11 2021 LCA decreased apoptosis and proliferative inhibition of Jurkat T cells caused by IFN-gamma-induced PD-L1-expressing in A549 cells in the co-culture system. licochalcone A 0-3 interferon gamma Homo sapiens 81-90 33130472-15 2021 N-acetyl-L-cysteine (NAC) not only revered ROS generation triggered by LCA but also restored IFN-gamma-induced expression of PD-L1. Acetylcysteine 0-19 interferon gamma Homo sapiens 93-102 33414972-4 2020 After interferon-gamma therapy was started at a dose of 200 microg/m2 three times a week, there was significant clinical improvement, with the need to continue the macrolide-based combination regimen. Macrolides 164-173 interferon gamma Homo sapiens 6-22 33353437-5 2022 In the patient group, elevated levels of IFN-gamma, IL-17A, and IL-10 had a significant association with the serum levels of 25(OH)D, while the levels of TGF-beta, IL-6, and TNF-alpha showed an insignificant association. 25(oh)d 125-132 interferon gamma Homo sapiens 41-50 33587435-7 2021 RBV cotreatment with DAA-therapy for HCV increased CD56Bright NK cell IFNgamma-responses in LTx-recipients (70.9% vs 89.2%; P=0.002) and this correlated to an increase in the inducibility of pSTAT-4 (MFI 157 vs 173; P=0.0002). daa 21-24 interferon gamma Homo sapiens 70-78 33368377-6 2021 GS-9688 increased the frequency of activated natural killer (NK) cells, mucosal-associated invariant T-cells (MAITs), CD4+ follicular helper T-cells (TFH ) and, in ~50% of patients, HBV-specific CD8+ T-cells expressing interferon-gamma (IFNgamma). Selgantolimod 0-7 interferon gamma Homo sapiens 219-235 33368377-6 2021 GS-9688 increased the frequency of activated natural killer (NK) cells, mucosal-associated invariant T-cells (MAITs), CD4+ follicular helper T-cells (TFH ) and, in ~50% of patients, HBV-specific CD8+ T-cells expressing interferon-gamma (IFNgamma). Selgantolimod 0-7 interferon gamma Homo sapiens 237-245 33368377-7 2021 Moreover, in vitro stimulation with GS-9688 induced NK cell expression of IFNgamma and TNFalpha and promoted hepatocyte lysis. Selgantolimod 36-43 interferon gamma Homo sapiens 74-82 33302918-10 2020 MIL-38-CD3 was able to mediate the activation of peripheral blood T cells from healthy individuals, resulting in the release of inflammatory cytokines TNF and IFN-g. mil-38-cd3 0-10 interferon gamma Homo sapiens 159-164 33290416-0 2020 Interferon-gamma promotes iron export in human macrophages to limit intracellular bacterial replication. Iron 26-30 interferon gamma Homo sapiens 0-16 33290416-3 2020 Interferon-gamma (IFN-gamma) is a central cytokine in host defense against intracellular pathogens and has been shown to promote iron export in macrophages. Iron 129-133 interferon gamma Homo sapiens 0-16 33270676-0 2020 TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients. Methotrexate 61-73 interferon gamma Homo sapiens 29-45 33270676-15 2020 CONCLUSIONS: In addition to the classic booster effect, TST conversions in patients using MTX can occur due to an increase in IFN-gamma. Methotrexate 90-93 interferon gamma Homo sapiens 126-135 33262321-9 2020 Compared with preparations of pDCs+T cells+vehicle, RSV infection (pDCs+T cells+RSV) significantly reduced and IFN-g treatment (pDC+T cells+IFN-g) increased kynurenic acid concentrations and the proportions of Foxp3+ Tregs (p<0.05 each). Kynurenic Acid 157-171 interferon gamma Homo sapiens 111-116 33262321-9 2020 Compared with preparations of pDCs+T cells+vehicle, RSV infection (pDCs+T cells+RSV) significantly reduced and IFN-g treatment (pDC+T cells+IFN-g) increased kynurenic acid concentrations and the proportions of Foxp3+ Tregs (p<0.05 each). Kynurenic Acid 157-171 interferon gamma Homo sapiens 140-145 33336491-6 2021 Notably, CD4+ T cells from patients in HAT and from persons using illicit heroin showed significant reduced proliferation and secretion of the pro-inflammatory cytokines IFN-gamma and IL-6 upon stimulation in vitro. Heroin 74-80 interferon gamma Homo sapiens 170-179 33489476-9 2020 Markers of T cell activation, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma), were also significantly reduced along with T cell proliferation following stimulated PBMC resveratrol treatment when compared to vehicle-treated controls (P < 0.01). Resveratrol 195-206 interferon gamma Homo sapiens 75-91 33489476-9 2020 Markers of T cell activation, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma), were also significantly reduced along with T cell proliferation following stimulated PBMC resveratrol treatment when compared to vehicle-treated controls (P < 0.01). Resveratrol 195-206 interferon gamma Homo sapiens 93-102 33315860-4 2020 We show that tumour necrosis factor (TNF), IFNgamma, and glutamate can provoke paranodal elongation in cerebellar slice cultures, which could be reversed by an N-methyl-D-aspartate (NMDA) receptor blocker. N-Methylaspartate 160-180 interferon gamma Homo sapiens 43-51 33315860-4 2020 We show that tumour necrosis factor (TNF), IFNgamma, and glutamate can provoke paranodal elongation in cerebellar slice cultures, which could be reversed by an N-methyl-D-aspartate (NMDA) receptor blocker. N-Methylaspartate 182-186 interferon gamma Homo sapiens 43-51 33331347-7 2020 Furthermore, we determined epithelial barrier integrity by measuring the flux of fluorescent-labeled dextran beads across a cell monolayer upon incubation with interferon-gamma. Dextrans 101-108 interferon gamma Homo sapiens 160-176 32120037-5 2020 RESULTS: Among the 154 patients enrolled, neutralizing anti-IFN-gamma Abs were detected in 50 (71%) of 70 patients with disseminated non-tuberculous mycobacterial infection (dNTM) but not in 84 patients without dNTM. dntm 174-178 interferon gamma Homo sapiens 60-69 32974883-15 2020 EXs from L363 cells pre-treated with either EPA or DHA are weaker stimulators of IFN-gamma production. Eicosapentaenoic Acid 44-47 interferon gamma Homo sapiens 81-90 32974883-15 2020 EXs from L363 cells pre-treated with either EPA or DHA are weaker stimulators of IFN-gamma production. Docosahexaenoic Acids 51-54 interferon gamma Homo sapiens 81-90 32991886-12 2020 PVP and Dex at all concentrations could significantly promote orbital fibroblast co-cultured with IFN-gamma apoptosis (P < 0.05). Povidone 0-3 interferon gamma Homo sapiens 98-107 32991886-12 2020 PVP and Dex at all concentrations could significantly promote orbital fibroblast co-cultured with IFN-gamma apoptosis (P < 0.05). Dexamethasone 8-11 interferon gamma Homo sapiens 98-107 32679620-3 2020 Antigen attached Biotin-PA nanofibers trigger splenocytes to produce high levels of cytokines (IFN-gamma, IL-12, TNF-alpha, and IL-6) and to exhibit a superior cross-presentation of the antigen. biotin-pa 17-26 interferon gamma Homo sapiens 95-104 33263856-1 2020 We examined the effects of 72-h exposure to atorvastatin and rosuvastatin in concentrations of 2-10 nM on the cytokine expression in LPS/IFNgamma-activated monocyte/macrophages derived from peripheral blood monocytes of healthy donors by culturing in the presence of GM-CSF. Atorvastatin 44-56 interferon gamma Homo sapiens 137-145 33263856-1 2020 We examined the effects of 72-h exposure to atorvastatin and rosuvastatin in concentrations of 2-10 nM on the cytokine expression in LPS/IFNgamma-activated monocyte/macrophages derived from peripheral blood monocytes of healthy donors by culturing in the presence of GM-CSF. Rosuvastatin Calcium 61-73 interferon gamma Homo sapiens 137-145 32120037-5 2020 RESULTS: Among the 154 patients enrolled, neutralizing anti-IFN-gamma Abs were detected in 50 (71%) of 70 patients with disseminated non-tuberculous mycobacterial infection (dNTM) but not in 84 patients without dNTM. dntm 211-215 interferon gamma Homo sapiens 60-69 32120037-6 2020 The median time from disease onset to the recognition of dNTM associated with neutralizing anti-IFNgamma Abs was 1.6 (range, 0.25-19 y) years. dntm 57-61 interferon gamma Homo sapiens 96-104 32865890-5 2020 Treatment with CP655 causes significant inhibition of cell proliferation and production of inflammatory cytokines such as interferon-gamma and interleukin-17. cp655 15-20 interferon gamma Homo sapiens 122-138 33157566-4 2020 The in vitro induction of IFN-gamma+ IL-17+ Th17 cells was performed adopting PHA and rIL-12. ril-12 86-92 interferon gamma Homo sapiens 26-35 32911016-2 2020 This study was undertaken to verify whether E2 action in human osteoblasts involves changes in the transcriptional profile of the TNF-alpha, IFN-gamma, NF-kappaB, TRAIL, TGF-beta, MMP2, MMP9, RECK, TIMP1, TIMP2, CDK2, CDK4, SRC, RUNX2, and SHH genes. Estradiol 44-46 interferon gamma Homo sapiens 141-150 32673595-11 2020 Pooled PPV for IFN-gamma release assay was 4 5% (95% CI 3 3-5 8) compared with 2 3% (1 5-3 1) for tuberculin skin test. DOP protocol 7-10 interferon gamma Homo sapiens 15-24 32180132-7 2020 IFN-gamma potently enhanced TNFA, IL12, HLADRA1 and LRRK2 expression, which was suppressed by FK506, a calcineurin-specific inhibitor, but further enhanced by LRRK2-specific kinase inhibitor (GSK2578215A). Tacrolimus 94-99 interferon gamma Homo sapiens 0-9 32180132-7 2020 IFN-gamma potently enhanced TNFA, IL12, HLADRA1 and LRRK2 expression, which was suppressed by FK506, a calcineurin-specific inhibitor, but further enhanced by LRRK2-specific kinase inhibitor (GSK2578215A). GSK2578215A 192-203 interferon gamma Homo sapiens 0-9 33173980-0 2020 Development of a dendrimer PAMAM-based gold biochip for rapid and sensitive detection of endogenous IFN-gamma and anti-IFN-gamma IgG in patients with hemophagocytic lymphohistiocytosis. Poly(amidoamine) 27-32 interferon gamma Homo sapiens 100-109 33173980-0 2020 Development of a dendrimer PAMAM-based gold biochip for rapid and sensitive detection of endogenous IFN-gamma and anti-IFN-gamma IgG in patients with hemophagocytic lymphohistiocytosis. Poly(amidoamine) 27-32 interferon gamma Homo sapiens 119-128 33095411-11 2020 Patients with elevated peripheral blood eosinophil count (PBEC, > 300 cells/mul) or serum interferon-gamma (IFN-gamma) level (> 100 pg/mL) treated with XC8 (100 mg) achieved a statistically significant improvement in FEV1 (11.33% predicted or 8.69% predicted, respectively, p < 0.05) as compared to the baseline versus the placebo. xc8 152-155 interferon gamma Homo sapiens 90-106 33173980-5 2020 The optimal immobilization concentration for Ab capture and the reaction concentration for detecting Ab on the PDITC-activated PAMAM-modified biochip were 6.25 and 3.12 microg/ml, respectively; the limit of detection of IFN-gamma protein was 50 pg/ml. Poly(amidoamine) 127-132 interferon gamma Homo sapiens 220-229 33173980-7 2020 The present results demonstrated that the PDITC-activated PAMAM-modified biochip might be a sensitive tool for the specific detection of IFN-gamma and anti-IFN-gamma Ab in serum, and might have clinical applicability for the diagnosis of HLH. Poly(amidoamine) 58-63 interferon gamma Homo sapiens 137-146 33095411-14 2020 Treatment with XC8 (100 mg) alleviated resistance to maintenance ICS therapy in patients with elevated IFN-gamma level. xc8 15-18 interferon gamma Homo sapiens 103-112 33266137-9 2020 Moreover, in vitro IL-15 stimulation enhanced degranulation and interferon-gamma production by PB NK from patients at month one of treatment with sorafenib. Sorafenib 146-155 interferon gamma Homo sapiens 64-80 32988295-4 2020 IFN-gamma increased kynurenine and interleukin-6 (IL-6) production by SCAP, without affecting the cell viability. Kynurenine 20-30 interferon gamma Homo sapiens 0-9 33296342-1 2020 INTRODUCTION: The interferon-gamma release assays as potent adjunct tools for the quick detection of TB in high burden countries is feasible. Terbium 101-103 interferon gamma Homo sapiens 18-34 33329581-7 2020 Rapamycin induced IFN-gamma-producing T-bet+Foxp3lo cells accompanied with enhanced lipid metabolism, whereas 2DG induced IFN-gamma-non-producing T-bet+Foxp3hi cells. Sirolimus 0-9 interferon gamma Homo sapiens 18-27 33329581-7 2020 Rapamycin induced IFN-gamma-producing T-bet+Foxp3lo cells accompanied with enhanced lipid metabolism, whereas 2DG induced IFN-gamma-non-producing T-bet+Foxp3hi cells. Deoxyglucose 110-113 interferon gamma Homo sapiens 122-131 33329581-8 2020 In memory CD4+ cells of SLE patients, inhibition of fatty acid synthesis, but not beta-oxidation, suppressed IFN-gamma production, and up-regulated of Foxp3 expression in T-bet+Foxp3+ cells. Fatty Acids 52-62 interferon gamma Homo sapiens 109-118 33329581-9 2020 Metabolic regulators such as fatty acid synthesis inhibitors may improve the pathological status by correcting Th1 subset imbalance and overproduction of IFN-gamma in SLE. Fatty Acids 29-39 interferon gamma Homo sapiens 154-163 33329581-0 2020 Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-gamma Overproduction in T Helper 1 Cells. Fatty Acids 9-19 interferon gamma Homo sapiens 60-69 33255891-7 2020 Pathway analyses showed interferon (IFN)-gamma-mediated signaling via NF-kappaB and JAK/STAT pathways to affect immune processes in a cell-specific manner and to interact with the inducible nitric oxide synthase. Nitric Oxide 190-202 interferon gamma Homo sapiens 24-46 33266022-8 2020 RESULTS: High-dose vitamin D treatment alone and combined with infliximab decreased the IL17A, IFNgamma and IL10 expression. Vitamin D 19-28 interferon gamma Homo sapiens 95-103 33266022-11 2020 CONCLUSIONS: High-dose vitamin D as monotherapy and combined with infliximab decreases IL17A, IFNgamma and IL-10 expression in mucosa within treatment groups. Vitamin D 23-32 interferon gamma Homo sapiens 94-102 33252790-4 2022 RESULTS: Children from the GAgP group presented lower IL-10 and IFN-gamma subgingival concentration than Health children, despite no difference in the clinical parameters. gagp 27-31 interferon gamma Homo sapiens 64-73 33252790-6 2022 IL-10/IL-1beta and IFN-gamma/IL-4 ratios were reduced in GAgP dyads, suggesting a familial trend in the subgingival cytokine"s profile. gagp 57-61 interferon gamma Homo sapiens 19-28 33553467-9 2021 Compared with healthy blood donor controls, CCP donors had significantly higher plasma levels of interferon (IFN)-gamma, interleukin (IL)-10, IL-15, IL-21, and macrophage-inflammatory protein-1, but lower levels of IL-1RA, IL-8, IL-16, and vascular endothelial growth factor-A (P < .0014). ccp 44-47 interferon gamma Homo sapiens 97-119 33324841-11 2020 However, only the glutaraldehyde conjugates provoked significant secretion of interleukin-2 (210.4 +- 11.45 vs 166.7 +- 9.15; p = 0.0059), interferon-gamma (210.5 +- 14.79 vs 144.1 +- 4.997; p = 0.0011), and tumor necrosis factor alpha (2075 +- 46.8 vs 1456 +- 144.8; p = 0.0082) compared to simple mixing. Glutaral 18-32 interferon gamma Homo sapiens 139-155 33261077-1 2020 The novel high-affinity tryptophan (Trp)-selective transport system is present at elevated levels in human interferon-gamma (IFN-gamma)-treated and indoleamine 2,3-dioxygenase 1 (IDO1)-expressing cells. Tryptophan 24-34 interferon gamma Homo sapiens 107-123 33261077-1 2020 The novel high-affinity tryptophan (Trp)-selective transport system is present at elevated levels in human interferon-gamma (IFN-gamma)-treated and indoleamine 2,3-dioxygenase 1 (IDO1)-expressing cells. Tryptophan 24-34 interferon gamma Homo sapiens 125-134 33261077-1 2020 The novel high-affinity tryptophan (Trp)-selective transport system is present at elevated levels in human interferon-gamma (IFN-gamma)-treated and indoleamine 2,3-dioxygenase 1 (IDO1)-expressing cells. Tryptophan 36-39 interferon gamma Homo sapiens 107-123 33261077-1 2020 The novel high-affinity tryptophan (Trp)-selective transport system is present at elevated levels in human interferon-gamma (IFN-gamma)-treated and indoleamine 2,3-dioxygenase 1 (IDO1)-expressing cells. Tryptophan 36-39 interferon gamma Homo sapiens 125-134 33261077-3 2020 We have previously shown that both IDO1 and tryptophanyl-tRNA synthetase (TrpRS), whose expression levels are increased by IFN-gamma, have a crucial function in high-affinity Trp uptake into human cells. Tryptophan 74-77 interferon gamma Homo sapiens 123-132 33208183-13 2020 Evodiamine suppressed IFN-gamma-induced PD-L1 expression in H1975 and H1650. evodiamine 0-10 interferon gamma Homo sapiens 22-31 32608473-12 2020 In the Flu and laminarin groups, the expression of interferon-gamma, tumor necrosis factor-alpha, CARD9, and phosphorylated nuclear factor kappa-B inhibitor alpha was decreased. Fluconazole 7-10 interferon gamma Homo sapiens 51-67 33172487-8 2020 Ex vivo apabetalone treatment countered cytokine secretion by DM2 + CVD monocytes at baseline (GROalpha and IL-8) and during IFNgamma stimulation (IL-1beta and TNFalpha). apabetalone 8-19 interferon gamma Homo sapiens 125-133 32608473-12 2020 In the Flu and laminarin groups, the expression of interferon-gamma, tumor necrosis factor-alpha, CARD9, and phosphorylated nuclear factor kappa-B inhibitor alpha was decreased. laminaran 15-24 interferon gamma Homo sapiens 51-67 33197057-7 2021 We found that BeSO4 can increase the levels of some inflammatory cytokine such as interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). beryllium sulfate 14-19 interferon gamma Homo sapiens 147-163 33197057-7 2021 We found that BeSO4 can increase the levels of some inflammatory cytokine such as interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). beryllium sulfate 14-19 interferon gamma Homo sapiens 165-174 33226640-6 2021 The ratio of IFN-gamma/IL-4 in URSA group was significantly higher than that of pregnancy group. ursa 31-35 interferon gamma Homo sapiens 13-22 33244226-7 2020 Moreover, miR-486-5p expression was significantly correlated with the expression of IL-6, IL-8, TNF-alpha, and IFN-gamma. mir-486-5p 10-20 interferon gamma Homo sapiens 111-120 33150583-10 2021 Clones proliferated and secreted IFN-gamma, IL-13 and cytolytic molecules following atabecestat or DIAT stimulation. Diatrizoate 99-103 interferon gamma Homo sapiens 33-42 33196459-7 2020 In retinoic acid-differentiated ATXN3/Q75-GFP SH-SY5Y cells inflamed with IFN-gamma-primed HMC3 conditioned medium, treatment with the tested compounds mitigated the increased caspase 1 activity and lactate dehydrogenase release, reduced polyQ aggregation and ROS and/or promoted neurite outgrowth. Tretinoin 3-16 interferon gamma Homo sapiens 74-83 33196459-7 2020 In retinoic acid-differentiated ATXN3/Q75-GFP SH-SY5Y cells inflamed with IFN-gamma-primed HMC3 conditioned medium, treatment with the tested compounds mitigated the increased caspase 1 activity and lactate dehydrogenase release, reduced polyQ aggregation and ROS and/or promoted neurite outgrowth. Reactive Oxygen Species 260-263 interferon gamma Homo sapiens 74-83 33171640-10 2020 Percentages of cellular cholesterol efflux were enhanced in presence or absence of IFN-gamma by 88% and 84% compared to control with 58 %and 62%, respectively. Cholesterol 24-35 interferon gamma Homo sapiens 83-92 33160404-6 2020 We carried out a multivariate Cox regression analysis and developed six ARG-related prognostic signature for the survival prediction of patients with squamous cell cervical cancer (Risk score = - 0.63*ATG3-0.42*BCL2 + 0.85*CD46-0.38*IFNG+ 0.23*NAMPT+ 0.82*TM9SF1). Arginine 72-75 interferon gamma Homo sapiens 233-237 33167329-9 2020 IFNgamma-induced indoleamine 2,3-dioxygenase (IDO) activity was identified as key mechanism to suppress human lymphocyte proliferation, as in the presence of the IDO inhibitor epacadostat (Epac) a stimulation of proliferation was seen. epacadostat 176-187 interferon gamma Homo sapiens 0-8 33167329-9 2020 IFNgamma-induced indoleamine 2,3-dioxygenase (IDO) activity was identified as key mechanism to suppress human lymphocyte proliferation, as in the presence of the IDO inhibitor epacadostat (Epac) a stimulation of proliferation was seen. epacadostat 189-193 interferon gamma Homo sapiens 0-8 33240107-9 2020 Therefore, IFN-gamma and SCGF-beta might be novel predictive plasma biomarker, as well as potential therapeutic targets specific for adult CSA-AKI. Cyclosporine 139-142 interferon gamma Homo sapiens 11-20 33151930-11 2020 Interestingly, AIH patients with serum total 25(OH)D levels of < 15 ng/mL had higher levels of inflammatory cytokines such as interferon-gamma and interleukin-33. 25(oh)d 45-52 interferon gamma Homo sapiens 126-142 32975550-5 2020 When HUCPV were cultured with degradable Mg, a moderate inflammation (e.g., lower secretions of pro-inflammatory interleukin 1 beta and IL2, and tumour necrosis factor alpha, interferon gamma, anti-inflammatory interleukins 4, 5, 10, 13, and 1 receptor antagonists and granulocyte colony stimulating factor), and an increased pro-healing M2 macrophage phenotype were observed. Magnesium 41-43 interferon gamma Homo sapiens 175-252 31811672-0 2020 Glucose-methanol based fed batch fermentation for the production of recombinant human interferon gamma (rhIFN-gamma) and evaluation of its antitumor potential. Methanol 0-16 interferon gamma Homo sapiens 86-115 32933968-3 2020 We demonstrated that branched N-glycans are used by colorectal cancer (CRC) cells to escape immune recognition, instructing the creation of immunosuppressive networks through inhibition of IFNgamma. n-glycans 30-39 interferon gamma Homo sapiens 189-197 33147541-1 2020 BACKGROUND: The present study was aimed to evaluate the nano-curcumin supplementation on Th1/Th17 balance by assessment of gene expression and serum level of interferon gamma (IFN-gamma) and interleukin-17 (IL-17) in migraine patients. Curcumin 61-69 interferon gamma Homo sapiens 158-185 33147541-4 2020 RESULTS: Compared to placebo group, two month nano-curcumin supplementation led to a significant reduction in serum levels and expression of IL-17 mRNA (P = 0.006 & 0.04, respectively), while there was no statistical difference regarding serum levels and expression of IFN-gamma mRNA. Curcumin 51-59 interferon gamma Homo sapiens 269-278 32778404-6 2020 The reactivity was verified with functional assays in which Tregs suppressed proliferation or interferon gamma production of autologous effector T cells (polyclonal and antigen-specific) used as responders challenged with the model peptide. tregs 60-65 interferon gamma Homo sapiens 94-110 33204297-5 2020 Gene Ontology (GO) analysis revealed that these genes were associated with peptidyl-tyrosine phosphorylation, skeletal system development, leukocyte migration, transcription regulation, T cell receptor and IFN-gamma-involved pathways, innate immune response, signal transduction, cell adhesion, angiogenesis, and hemopoiesis. Tyrosine 83-92 interferon gamma Homo sapiens 206-215 33158915-10 2020 By targeting the SOX2-JAK-STAT signaling, SAHA promoted the antitumor efficacy of IFNgamma or anti-PD-1 in vitro and in vivo. Vorinostat 42-46 interferon gamma Homo sapiens 82-90 32952647-10 2020 By contrast, double azide caused a significant decrease in the levels of IFN-gamma and IL-6. Azides 20-25 interferon gamma Homo sapiens 73-82 32952647-11 2020 The results of the present study indicated that mCRP, pCRP, oxLD and possibly azide, individually or in different combinations, had the tendency to upregulate the expression of IL-4 and to downregulate that of the pro-atherogenic cytokines, IFN-gamma and IL-6, suggesting that the intima microenvironment serves a crucial role in atherogenesis. Azides 78-83 interferon gamma Homo sapiens 241-250 32777075-10 2020 Amoxicillin-modified KP-2 and KP-3 peptide-specific CD4+ clones proliferated and secreted IFN-gamma, IL-10, perforin and/or IL-17/IL-22 in a dose-dependent manner and displayed no cross-reactivity with amoxicillin, unmodified peptide or with positional derivatives. Amoxicillin 0-11 interferon gamma Homo sapiens 90-99 32794350-5 2020 In the immunized mice, TIO3 formulated in microbial vaccines dramatically reduced surface-bound TGF-beta2 expression on CD4+ T cells and CD19+ B cells in the lymph node (LN) cells and spleen cells; up-regulated the expression of CD40, CD80, CD86, and MHC II molecules on CD19+ B cells and CD11c+ dendritic cells; and promoted IFN-gamma production in CD4+ T cells and CD8+ T cells in the LN cells. tio3 23-27 interferon gamma Homo sapiens 326-335 32032292-0 2020 Inverse Association Between the Quantity of Human Peripheral Blood CXCR5+IFN-gamma+CD8+ T Cells With De Novo DSA Production in the First Year After Kidney Transplant. dsa 109-112 interferon gamma Homo sapiens 73-82 33172559-14 2020 After correction of the factors of breastfeeding, maternal food allergy, and maternal history of allergic diseases, it was found that maternal low IL-2 and IFN-gamma at the third trimester were still significantly associated with CMPA in infants (P<0.05). Q nucleotide 230-234 interferon gamma Homo sapiens 156-165 33125792-0 2021 Interferon-gamma decreases ATP-binding cassette subfamily G member 1 (ABCG1)-mediated cholesterol efflux through small ubiquitin-like modifier (SUMO)/ubiquitin-dependent liver X receptor-alpha degradation in macrophages. Cholesterol 86-97 interferon gamma Homo sapiens 0-16 32557888-4 2020 Moreover, in ovo administration of live NDV vaccine plus APS could significantly enhance the serum anti-NDV antibody titres and interferon gamma (IFN-gamma), interleukin (IL)-2, IL-4 and IL-6 concentrations, promote lymphocyte proliferative capability as well as improve the frequencies of CD4+ and CD8+ T cells in peripheral blood. aps 57-60 interferon gamma Homo sapiens 128-155 33125792-1 2021 The effects of interferon-gamma (IFN-gamma) on cholesterol accumulation and the development of foam cells are still unclear. Cholesterol 47-58 interferon gamma Homo sapiens 33-42 33125792-3 2021 The process was dependent on its interactions with phosphorylated signal transducer and activator of transcription 1 (p-STAT1) and protein inhibitor of activated STAT 1 (PIAS1), because both fludarabine and PIAS1 shRNA reversed the decrease in LXR-alpha protein expression induced by IFN-gamma. fludarabine 191-202 interferon gamma Homo sapiens 284-293 33125792-7 2021 In addition, K22R or K326R mutation almost completely restored ATP-binding cassette subfamily G member 1 (ABCG1)-mediated cholesterol efflux in IFN-gamma-treated macrophages. Cholesterol 122-133 interferon gamma Homo sapiens 144-153 33125792-8 2021 Taken together, these findings indicate that IFN-gamma promotes LXR-alpha degradation through a SUMO-ubiquitin-dependent pathway, which may inhibit cholesterol efflux mediated by ABCG1 from macrophages and promote the development of atherosclerosis. Cholesterol 148-159 interferon gamma Homo sapiens 45-54 33140051-8 2020 Mechanistically, the STAT1/IRF1 axis activated by TNF-alpha and IFN-gamma co-treatment induced iNOS for the production of nitric oxide. Nitric Oxide 122-134 interferon gamma Homo sapiens 64-73 33126239-4 2020 Both original and generic GA at concentrations 50-200 mug/ml dose-dependently inhibited interleukin-17 and interferon-gamma production by anti-CD3/anti-CD28-activated peripheral blood mononuclear cells from MS patients and healthy subjects. Glatiramer Acetate 26-28 interferon gamma Homo sapiens 107-123 33126239-7 2020 These GA/LPS-treated DCs induced lower interleukin-17 and interferon-gamma production by autologous CD4+ T cells compared to LPS-treated DCs. Glatiramer Acetate 6-8 interferon gamma Homo sapiens 58-74 33115954-6 2020 NaBi treatment of post-allo-HCT patients with relapsed AML improved metabolic fitness and interferon-gamma production in T cells. nabi 0-4 interferon gamma Homo sapiens 90-106 33114438-13 2020 As a result, we identified that Ac2-26 significantly decreased the expression of TNF-alpha/IFN-gamma-stimulated pro-inflammatory chemokines, including IL-1beta, IL-6, IL-8, MDC, TARC, and TNF-alpha, by inhibiting the activation of MAPK, NF-kappaB, and JAK/STAT pathway in TNF-alpha/IFN-gamma-stimulated HaCaT human keratinocytes. annexin A1 peptide (2-26) 32-38 interferon gamma Homo sapiens 91-100 32818918-8 2020 In unadjusted models, cannabinoid-positive participants had lower interferon-gamma (IFN-gamma) levels (p = 0.046), but this finding was not significant after adjusting for covariates and multiple comparisons. Cannabinoids 22-33 interferon gamma Homo sapiens 66-82 32818918-8 2020 In unadjusted models, cannabinoid-positive participants had lower interferon-gamma (IFN-gamma) levels (p = 0.046), but this finding was not significant after adjusting for covariates and multiple comparisons. Cannabinoids 22-33 interferon gamma Homo sapiens 84-93 33114438-13 2020 As a result, we identified that Ac2-26 significantly decreased the expression of TNF-alpha/IFN-gamma-stimulated pro-inflammatory chemokines, including IL-1beta, IL-6, IL-8, MDC, TARC, and TNF-alpha, by inhibiting the activation of MAPK, NF-kappaB, and JAK/STAT pathway in TNF-alpha/IFN-gamma-stimulated HaCaT human keratinocytes. annexin A1 peptide (2-26) 32-38 interferon gamma Homo sapiens 282-291 33105546-8 2020 In BD-treated cells, Wnt/beta-catenin signaling (p = 3.15 x 10-4) gene sets were enriched, whereas enrichment of interferon gamma (IFN-gamma) response (p = 3 x 10-3) was observed in TC-treated cells. Technetium 182-184 interferon gamma Homo sapiens 113-140 33087723-5 2020 Accordingly, patient-derived lymphocytes exhibit increased STAT activation in vitro in response to interferon-gamma, IL-2 and IL-4 that is reverted by the JAK1/JAK2 inhibitor ruxolitinib. ruxolitinib 175-186 interferon gamma Homo sapiens 99-115 33100272-1 2020 OBJECTIVE: This study aims to explore the molecular mechanism of macrophages and gammadelta-T cells in the ZOL drug-induced osteonecrosis of jaws based on the IFN-gamma involved osteoblast differentiation signaling pathway. Zoledronic Acid 107-110 interferon gamma Homo sapiens 159-168 33116743-5 2020 We performed univariate and multivariate analyses using several perioperative variables and administration of TJ-100/placebo to determine the effect of TJ-100 on the levels of IFN-gamma and IL-9. tj-100 152-158 interferon gamma Homo sapiens 176-185 32986791-9 2020 Both CD69-TTE and CD69+TTE cells from the BM of NDMM produce large amounts of the inflammatory cytokines interferon-gamma and tumor necrosis factor alpha. ndmm 48-52 interferon gamma Homo sapiens 105-153 32526304-6 2020 Additionally, HSP-W significantly induced NO and ROS production as well as the release of IL-1beta, IFN-gamma, TNF-alpha, and IL-6, and upregulated pinocytic and phagocytic capacities of THP-1 cells. hsp-w 14-19 interferon gamma Homo sapiens 100-109 33060625-5 2020 Calcipotriol reduced T cell proliferation and production of IFN-gamma, granzyme B and IL-17, but increased IL-10 secretion. calcipotriene 0-12 interferon gamma Homo sapiens 60-69 33048944-9 2020 Our results show that high-density mannose dendrimers are preferentially bound by macrophages treated by IFNgamma and LPS that express lower levels of MRC1 than for macrophages treated by IL-4 that express high levels of MRC1. Mannose 35-42 interferon gamma Homo sapiens 105-113 33132753-6 2020 We found that PB-MNC of SCD patients with or without ON presented significantly reduced TCD4+, TCD8+, and TCD4+ naive cell frequencies and increased frequency of circulating CD4+T cells able to simultaneously produce IFN-gamma +/IL4+ and IL-17+/IL4+ compared to healthy controls. Lead 14-16 interferon gamma Homo sapiens 217-226 33110368-7 2020 Co-treatment of PMA-ionomycin with AST-VII and PEG300: Chol-AST-VII LNPs significantly increased the levels of IL-2 and IFN-g, compared to PMA-ionomycin alone. PMA ionomycin 16-29 interferon gamma Homo sapiens 120-125 33110368-7 2020 Co-treatment of PMA-ionomycin with AST-VII and PEG300: Chol-AST-VII LNPs significantly increased the levels of IL-2 and IFN-g, compared to PMA-ionomycin alone. polyethylene glycol 300 47-53 interferon gamma Homo sapiens 120-125 33110368-8 2020 In the presence of H3N2, AST-VII was able to augment IL-17A, while PEG300: Chol-AST-VII LNPs stimulated the production of IFN-g. polyethylene glycol 300 67-73 interferon gamma Homo sapiens 122-127 33110368-8 2020 In the presence of H3N2, AST-VII was able to augment IL-17A, while PEG300: Chol-AST-VII LNPs stimulated the production of IFN-g. chol 75-79 interferon gamma Homo sapiens 122-127 33050076-3 2020 Aromadendrin effectively regulated IL-2 and IFNgamma production in vitro from activated Jurkat T cells without cytotoxicity. aromadedrin 0-12 interferon gamma Homo sapiens 44-52 33031288-11 2020 The role of interferon-gamma and activated T cells in tofacitinib-related HZ deserves further investigation. tofacitinib 54-65 interferon gamma Homo sapiens 12-28 32749395-5 2020 Furthermore, T cell infiltration, and secretion of IL-2 and IFN-gamma were dramatically reduced in the GM-FK506 group. gm 103-105 interferon gamma Homo sapiens 60-69 32749395-5 2020 Furthermore, T cell infiltration, and secretion of IL-2 and IFN-gamma were dramatically reduced in the GM-FK506 group. Tacrolimus 106-111 interferon gamma Homo sapiens 60-69 33312061-4 2020 Neopterin (NP) produced by monocytes/macrophages in response to stimulation by interferon-gamma (IFN-gamma) is emphasized in recent findings. Neopterin 0-9 interferon gamma Homo sapiens 79-95 33123143-10 2020 Pre-incubation of NK cells with DHA further decreased the frequency of NKp46+ NK cells in the co-culture with neutrophils and decreased the concentrations of IFN-gamma, CCL3 and GM-CSF. Docosahexaenoic Acids 32-35 interferon gamma Homo sapiens 158-167 33312061-4 2020 Neopterin (NP) produced by monocytes/macrophages in response to stimulation by interferon-gamma (IFN-gamma) is emphasized in recent findings. Neopterin 0-9 interferon gamma Homo sapiens 97-106 33312061-4 2020 Neopterin (NP) produced by monocytes/macrophages in response to stimulation by interferon-gamma (IFN-gamma) is emphasized in recent findings. Neopterin 11-13 interferon gamma Homo sapiens 79-95 33312061-4 2020 Neopterin (NP) produced by monocytes/macrophages in response to stimulation by interferon-gamma (IFN-gamma) is emphasized in recent findings. Neopterin 11-13 interferon gamma Homo sapiens 97-106 32763614-4 2020 The immunomodulatory extracellular matrix hydrogels (iECM) consist of an interpenetrating network of click functionalized-alginate and fibrillar collagen, in which interferon gamma (IFN-gamma) loaded heparin-coated beads are incorporated. Alginates 122-130 interferon gamma Homo sapiens 164-191 33377877-13 2020 On the other hand, IL-17 and IFN-gamma decreased after TACE in both groups, although not statistically significant. Chlorotrianisene 55-59 interferon gamma Homo sapiens 29-38 33377877-15 2020 CONCLUSION: increased circulating Th1, Th17, and CD4+/IFN-gamma+/IL-17+ T cells were observed in HCC patients with complete or partial response to TACE. Chlorotrianisene 147-151 interferon gamma Homo sapiens 54-63 32864794-7 2020 Compared with alum-treated groups, more than six times higher antigen-specific antibody titer and three-fold more IFN-gamma-secreting T cells are induced, indicating the potent humoral and cellular immune activations. Aluminum Hydroxide 14-18 interferon gamma Homo sapiens 114-123 33062579-6 2020 D. oil was found to stimulate the proliferation of human peripheral blood mononuclear cells (PBMC) and, also enhanced the secretion of IL-2, IFN-gamma and TNF-alpha. Oils 3-6 interferon gamma Homo sapiens 141-150 32763614-4 2020 The immunomodulatory extracellular matrix hydrogels (iECM) consist of an interpenetrating network of click functionalized-alginate and fibrillar collagen, in which interferon gamma (IFN-gamma) loaded heparin-coated beads are incorporated. Heparin 200-207 interferon gamma Homo sapiens 164-191 32763614-6 2020 Moreover, the inclusion of IFN-gamma loaded heparin-coated beads prolonged the expression of key regulatory genes upregulated upon licensing, including indoleamine 2,3-dioxygenase 1 (IDO1) and galectin-9 (GAL9). Heparin 44-51 interferon gamma Homo sapiens 27-36 32569898-8 2020 ASFV-BA71V and LPS/IFN-gamma share similar antiviral response of porcine AM. porcine am 65-75 interferon gamma Homo sapiens 19-28 32758800-10 2020 KP markedly boosted the reactivity and cross-reactivity of PRRSV type-1- and PCV2b-specific IFN-gamma SC. lysylproline 0-2 interferon gamma Homo sapiens 92-101 32763913-3 2020 Serum and forearm skin analysis, both at protein expression and transcriptomic level, indicated that increased expression of factors such as IFNgamma, VEGF and sVCAM-1 were associated with DFU healing. 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone 189-192 interferon gamma Homo sapiens 141-149 32679285-4 2020 In this study, we evaluated the anti-inflammatory/antioxidant activity as well as wound healing capacity of a well-characterized OEO on human keratinocytes NCTC 2544 treated with interferon-gamma (IFN-gamma) and histamine (H) or subjected to a scratch test. oeo 129-132 interferon gamma Homo sapiens 179-195 32679285-4 2020 In this study, we evaluated the anti-inflammatory/antioxidant activity as well as wound healing capacity of a well-characterized OEO on human keratinocytes NCTC 2544 treated with interferon-gamma (IFN-gamma) and histamine (H) or subjected to a scratch test. oeo 129-132 interferon gamma Homo sapiens 197-206 32679285-9 2020 In IFN-gamma and H treated cells, OEO displayed a significant reduction of ROS, ICAM-1, iNOS, COX-2, 8-OHdG, MMP-1, and MMP-12. oeo 34-37 interferon gamma Homo sapiens 3-12 32564679-7 2020 Additionally, the protective effect of miR-375-3p on inflammatory response in TNF-alpha and IFN-gamma-treated HaCaT cells could be impeded by YAP1 overexpression. mir-375-3p 39-49 interferon gamma Homo sapiens 92-101 32702804-7 2020 After adjustment for age, BMI, menstrual cycle, and parity history, creatinine-adjusted BPA was significantly associated with increases in 8-isoprostane (beta = 0.74, 95% CI = 0.07, 1.41; p = 0.031) and IFN-gamma (beta = 0.18, 95% CI = 0.00, 0.36; p = 0.046). Creatinine 68-78 interferon gamma Homo sapiens 203-212 32702804-7 2020 After adjustment for age, BMI, menstrual cycle, and parity history, creatinine-adjusted BPA was significantly associated with increases in 8-isoprostane (beta = 0.74, 95% CI = 0.07, 1.41; p = 0.031) and IFN-gamma (beta = 0.18, 95% CI = 0.00, 0.36; p = 0.046). 8-epi-prostaglandin F2alpha 139-152 interferon gamma Homo sapiens 203-212 32696549-8 2020 In vitro treatment of leukemic cells with interferon-gamma and demethylating agent 5-azacytidine (5-AC) induced SBSN expression. Azacitidine 98-102 interferon gamma Homo sapiens 42-58 32703116-15 2020 Regarding cytokine analysis, a negative correlation between daily caffeine consumption and serum level of IFNgamma was found (p = 0.03, r = -0.2); furthermore, patients with a high intake of caffeine showed lower serum levels of IFNalpha (p = 0.02), IL-17 (p = 0.01) and IL-6 (p = 0.003). Caffeine 66-74 interferon gamma Homo sapiens 106-114 32703116-15 2020 Regarding cytokine analysis, a negative correlation between daily caffeine consumption and serum level of IFNgamma was found (p = 0.03, r = -0.2); furthermore, patients with a high intake of caffeine showed lower serum levels of IFNalpha (p = 0.02), IL-17 (p = 0.01) and IL-6 (p = 0.003). Caffeine 191-199 interferon gamma Homo sapiens 106-114 33109629-10 2020 Importantly, N-820 significantly enhanced in vitro cytotoxicity (p<0.001) of exPBNK with enhanced granzyme B and IFN-gamma release (p<0.001) against BL. n-820 13-18 interferon gamma Homo sapiens 113-122 32822738-4 2020 After screening our chemical library, we found that salinomycin potently inhibited IFN-gamma-stimulated kynurenine synthesis with IC50 values of 3.36-4.66 muM in both human cervical and breast cancer cells. salinomycin 52-63 interferon gamma Homo sapiens 83-92 32945463-7 2020 Conversely, the pretreatment with the STAT1 inhibitor fludarabine decreased the apoptotic rate of human melanocytes following IFN-gamma induction. fludarabine 54-65 interferon gamma Homo sapiens 126-135 32631655-6 2020 RESULTS: Human pancreatic cells express PD-L1 when cultured with interferon-gamma: quantitative polymerase chain reaction MiaPaca (15.2 rel. miapaca 122-129 interferon gamma Homo sapiens 65-81 32822738-4 2020 After screening our chemical library, we found that salinomycin potently inhibited IFN-gamma-stimulated kynurenine synthesis with IC50 values of 3.36-4.66 muM in both human cervical and breast cancer cells. Kynurenine 104-114 interferon gamma Homo sapiens 83-92 32822738-8 2020 Activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway by IFN-gamma was significantly suppressed by salinomycin, via inhibiting the Jak1, Jak2, and STAT1/3 phosphorylation. salinomycin 144-155 interferon gamma Homo sapiens 102-111 32822738-10 2020 Furthermore, salinomycin significantly restored the proliferation of T cells co-cultured with IFN-gamma-treated breast cancer cells and potentiated antitumor activity of cisplatin in vivo. salinomycin 13-24 interferon gamma Homo sapiens 94-103 32978426-6 2020 Under long-term BPA exposure, significant telomere length shortening, reduction in mitochondrial DNA copy number, cell proliferation and IFN-gamma as well as hTERT protein suppression could be observed in CD8 + lymphocytes, as analysed by qRT-PCR, flow cytometry and western blot analysis. bisphenol A 16-19 interferon gamma Homo sapiens 137-146 32990225-9 2020 CONCLUSIONS: Processing with sodium hydroxide can significantly improve the antitumor activity of cantharides, which inhibits the proliferation, migration and invasion of A549 cells possibly by down-regulating the expressions of MMP1 and MMP2, promoting apoptosis and increasing the level of IFN-gamma. Sodium Hydroxide 29-45 interferon gamma Homo sapiens 292-301 32990225-9 2020 CONCLUSIONS: Processing with sodium hydroxide can significantly improve the antitumor activity of cantharides, which inhibits the proliferation, migration and invasion of A549 cells possibly by down-regulating the expressions of MMP1 and MMP2, promoting apoptosis and increasing the level of IFN-gamma. Cantharidin 98-109 interferon gamma Homo sapiens 292-301 33062720-3 2020 Also, CQ and HCQ inhibit the production of interferon- (IFN-) alpha and IFN-gamma and/or tumor necrotizing factor- (TNF-) alpha. Chloroquine 6-8 interferon gamma Homo sapiens 72-81 33062720-3 2020 Also, CQ and HCQ inhibit the production of interferon- (IFN-) alpha and IFN-gamma and/or tumor necrotizing factor- (TNF-) alpha. Hydroxychloroquine 13-16 interferon gamma Homo sapiens 72-81 33117343-7 2020 Furthermore, AZM significantly inhibited the inflammatory cytokines IFN-gamma and IL-4 production, CCR4 and CXCR3 receptor expression, and viability of Th0, Th1-like, and Th2-like subsets. Azithromycin 13-16 interferon gamma Homo sapiens 68-77 32759352-1 2020 Quantiferon-TB Gold Plus (QFT-Plus) is the most widely used interferon-gamma release assay (IGRA) for the diagnosis of latent tuberculosis infection (LTBI). -tb gold plus 11-24 interferon gamma Homo sapiens 60-76 33003293-5 2020 In contrast, the IFN-gamma-associated gene signature was an independent prognostic factor in the whole cohort (HR 2.287, 95% CI 1.410-3.633, p < 0.001) as well as in the basal-like (HR 3.458, 95% CI 1.154-10.359, p = 0.027) and luminal B (HR 2.690, 95% CI 1.416-5.112, p = 0.003) molecular subtypes. Phenobarbital 228-235 interferon gamma Homo sapiens 17-26 32719030-1 2020 Interferon-gamma (IFN-gamma) release assays (IGRAs) are increasingly used to test for latent TB infection. Terbium 93-95 interferon gamma Homo sapiens 0-16 32641415-6 2020 This resulted in increased T-cell secretion of IFNgamma, which reduced intracellular glutathione (GSH) production and sensitized chemosensitive cells to cis-diaminedichloroplatinum (CDDP)-induced apoptosis. Glutathione 85-96 interferon gamma Homo sapiens 47-55 32719030-1 2020 Interferon-gamma (IFN-gamma) release assays (IGRAs) are increasingly used to test for latent TB infection. Terbium 93-95 interferon gamma Homo sapiens 18-27 32967164-5 2020 ST2825 significantly downregulates the production of IFN-gamma, IL-6, IL-12, IL-2, IL-15, IL-7, VEGF, IL-1Ra, IL-4, IL-5, IL-13 and IL-9 (p < 0.05) in LPS-stimulated PBMC. ST2825 0-6 interferon gamma Homo sapiens 53-62 32641415-6 2020 This resulted in increased T-cell secretion of IFNgamma, which reduced intracellular glutathione (GSH) production and sensitized chemosensitive cells to cis-diaminedichloroplatinum (CDDP)-induced apoptosis. Glutathione 98-101 interferon gamma Homo sapiens 47-55 32641415-6 2020 This resulted in increased T-cell secretion of IFNgamma, which reduced intracellular glutathione (GSH) production and sensitized chemosensitive cells to cis-diaminedichloroplatinum (CDDP)-induced apoptosis. Cisplatin 153-180 interferon gamma Homo sapiens 47-55 32641415-6 2020 This resulted in increased T-cell secretion of IFNgamma, which reduced intracellular glutathione (GSH) production and sensitized chemosensitive cells to cis-diaminedichloroplatinum (CDDP)-induced apoptosis. Cisplatin 182-186 interferon gamma Homo sapiens 47-55 32641415-8 2020 IFNgamma secretion was therefore reduced, resulting in high GSH production and resistance to CDDP-induced death in ovarian cancer cells. Glutathione 60-63 interferon gamma Homo sapiens 0-8 32641415-8 2020 IFNgamma secretion was therefore reduced, resulting in high GSH production and resistance to CDDP-induced death in ovarian cancer cells. Cisplatin 93-97 interferon gamma Homo sapiens 0-8 32646922-11 2020 In both humans and mice, metformin triggered AMPK activation and STAT3 inactivation, and altered the production of effector cytokines (i.e. TNF-alpha, IFN-gamma, IL-10) in the immune cells. Metformin 25-34 interferon gamma Homo sapiens 151-160 32973967-8 2020 Analyses based in hormone receptors such as estrogen (ER) and progesterone (PR) receptors also revealed protective (for SNPs rs3212227-IL12B; rs3024896 and rs3821236-STAT4) and predisposing (for rs2069705-IFNG SNP) BC associations. Progesterone 62-74 interferon gamma Homo sapiens 205-209 32497592-9 2020 Maternal CORT treatment reduced maternal hippocampal IFN-gamma, and both hippocampal and plasma TNF-alpha. Corticosterone 9-13 interferon gamma Homo sapiens 53-62 32899567-5 2020 As a result, cultured iPS-RPE cells inhibited cell proliferation and the production of IFN-gamma by activated uveitis CD4+ T cells, especially Th1-type T cells. IPS 22-25 interferon gamma Homo sapiens 87-96 32561292-6 2020 Peficitinib inhibited STAT3 phosphorylation in RA-FLS following induction by interferon (IFN)-alpha2b, IFN-gamma, interleukin (IL)-6, oncostatin M, and leukemia inhibitory factor in a concentration-related manner, and was comparable to approved JAK inhibitors, tofacitinib and baricitinib. peficitinib 0-11 interferon gamma Homo sapiens 103-112 33013932-7 2020 In addition, rapamycin abrogated the ability of both DC subtypes to promote the proliferation and differentiation of IFN-y and Granzyme B producing CD8 + T cells. Sirolimus 13-22 interferon gamma Homo sapiens 117-122 32899901-6 2020 (3) Results: There was a significant decrease in the levels of IFN-gamma+ Type-1 T helper cells (Th1) in patients with MoM THA compared to the ceramic-on-polyethylene control group (p < 0.001). Polyethylene 154-166 interferon gamma Homo sapiens 63-72 32899567-8 2020 iPS-RPE expressed these negative costimulatory molecules, especially when RPE cells were pretreated with recombinant IFN-gamma. IPS 0-3 interferon gamma Homo sapiens 117-126 32739118-5 2020 The ssRNA adjuvant stimulated not only well-balanced cellular (indicated by IgG2a, IFN-gamma, IL-2, and TNF-alpha) and humoral (indicated by IgG1 and IL-4) immune responses but also a mucosal immune response (indicated by IgA), a key protector against respiratory virus infections. ssrna adjuvant 4-18 interferon gamma Homo sapiens 83-92 32830985-0 2020 Total Synthesis of Glycosylated Human Interferon-gamma. glycosylated 19-31 interferon gamma Homo sapiens 38-54 32830985-2 2020 Herein, we describe the total chemical synthesis of homogeneously glycosylated variants of human IFN-gamma using a tandem diselenide-selenoester ligation-deselenization strategy in the C- to N-terminal direction. diselenium 122-132 interferon gamma Homo sapiens 97-106 32830985-2 2020 Herein, we describe the total chemical synthesis of homogeneously glycosylated variants of human IFN-gamma using a tandem diselenide-selenoester ligation-deselenization strategy in the C- to N-terminal direction. selenoester 133-144 interferon gamma Homo sapiens 97-106 33014780-7 2020 Then, after gene expression profiling experiments, we found that several "antiviral" genes, such as CD28 and IFN gamma, were upregulated, while genes with "proviral" action, such as ARG-1, CEACAM1, and FUT4, were less expressed during treatment with imatinib, thus demonstrating that TKIs are not detrimental from the immunological point of view. Imatinib Mesylate 250-258 interferon gamma Homo sapiens 109-118 32660717-9 2020 After anaesthesia with propofol and remifentanil, IL17 (P=0.013), interferon gamma (P=0.003), and MICA (P=0.001) decreased, but IL6 (P=0.006) and L-selectin (P=0.001) increased. Propofol 23-31 interferon gamma Homo sapiens 66-82 32701602-7 2020 Individual subsets of activated T cells can secrete tumor necrosis factor-alpha (TNF-alpha), interleukin-17a (IL-17a), and interferon-gamma (IFN-gamma), each of which has augmented the elevation of blood pressure in hypertensive models by enhancing renal sodium transport. Sodium 255-261 interferon gamma Homo sapiens 141-150 32383139-4 2020 Module-trait assay showed that the blue module (cor = 0.97, P < 0.001) was associated with CAF-related chemo-resistance, which was enriched mainly as "inflammatory response", "interferon-gamma-mediated signaling" and "NIK/NF-kappaB signaling" pathways. cafestol palmitate 91-94 interferon gamma Homo sapiens 176-192 31900456-0 2020 A serine protease inhibitor induces type 1 regulatory T cells through IFN-gamma/STAT1 signaling. cholecystokinin C-terminal flanking peptide 2-8 interferon gamma Homo sapiens 70-79 32861198-9 2020 We detected basal LAG3 mRNA expression in the melanoma cell A375 and an interferon-gamma inducible expression after demethylation with 5-azacytidine. Azacitidine 135-148 interferon gamma Homo sapiens 72-88 32738204-2 2020 Acutely, assimilation of acetate expands the capacity of memory CD8+ T cells to produce IFN-gamma. Acetates 25-32 interferon gamma Homo sapiens 88-97 32646751-0 2020 Hyperlipidaemia and IFNgamma/TNFalpha Synergism are associated with cholesterol crystal formation in Endothelial cells partly through modulation of Lysosomal pH and Cholesterol homeostasis. Cholesterol 68-79 interferon gamma Homo sapiens 20-28 32646751-0 2020 Hyperlipidaemia and IFNgamma/TNFalpha Synergism are associated with cholesterol crystal formation in Endothelial cells partly through modulation of Lysosomal pH and Cholesterol homeostasis. Cholesterol 165-176 interferon gamma Homo sapiens 20-28 32646751-13 2020 INTERPRETATION: Our results provide evidence that IFNgamma and TNFalpha accelerate CC formation in endothelial cells in part by altering lysosomal pH and free cholesterol load. Cholesterol 159-170 interferon gamma Homo sapiens 50-58 32565333-10 2020 RESULTS: There was a significant decrease in the levels of PGE2, TNF-alpha, IL-6, and IFN-gamma in the ibuprofen group as compared to the non-ibuprofen group. Ibuprofen 103-112 interferon gamma Homo sapiens 86-95 32758455-2 2020 The radiosensitising effect of Debio 1143 is mediated through caspase activation and TNF, IFNgamma, CD8 T cell-dependent pathways. N-benzhydryl-5-(2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo(1,2-a)(1,5)diazocine-8-carboxamide 31-41 interferon gamma Homo sapiens 90-98 31981371-10 2020 Addition of poly I:C significantly enhanced the expression and secretion of IFNgamma, IDO and HLA-G. Poly I 12-18 interferon gamma Homo sapiens 76-84 32782183-0 2020 Effect of IFN-gamma on the kynurenine/tryptophan ratio in monolayer-cultured keratinocytes and a 3D reconstructed human epidermis model. Kynurenine 27-37 interferon gamma Homo sapiens 10-19 32782183-3 2020 However, the trp metabolism in keratinocytes exposed to IFN-gamma is not yet fully understood. Tryptophan 13-16 interferon gamma Homo sapiens 56-65 32782183-4 2020 OBJECTIVE: The aim of this study was to establish a human epidermis model in order to quantify cytokine and kyn/trp secretion from IFN-gamma stimulated cells and tissues. Kynurenine 108-111 interferon gamma Homo sapiens 131-140 32782183-4 2020 OBJECTIVE: The aim of this study was to establish a human epidermis model in order to quantify cytokine and kyn/trp secretion from IFN-gamma stimulated cells and tissues. Tryptophan 112-115 interferon gamma Homo sapiens 131-140 32782183-10 2020 RESULTS: Trp catabolism to kyn was significantly increased (P < 0.01) in the 2D culture in response to IFN-gamma treatment. Tryptophan 9-12 interferon gamma Homo sapiens 103-112 32782183-15 2020 CONCLUSION: Our results suggest that IFN-gamma acts as an inducer of trp degradation preferentially in undifferentiated keratinocytes, indicated by the IDO expression in the basal layer of the RHE. Tryptophan 69-72 interferon gamma Homo sapiens 37-46 32866942-0 2020 QuantiFERON-TB Gold Plus combined with HBHA-Induced IFN-gamma release assay improves the accuracy of identifying tuberculosis disease status. HBHA 39-43 interferon gamma Homo sapiens 52-61 32866942-7 2020 While the HBHA-induced IFN-gamma response did not differ between ATB and HC (median 12.12 pg/mL versus 10.95 pg/mL; P = 0.463), but was significantly higher in the LTBI (median 69.67 pg/mL; both P < 0.0001). HBHA 10-14 interferon gamma Homo sapiens 23-32 32824699-7 2020 In human NK cells, heparin promisingly increased interferon (IFN)-gamma production in synergy with IL-12, although the mechanism remains elusive. Heparin 19-26 interferon gamma Homo sapiens 49-71 32942172-5 2020 THC-induced Tregs are necessary to remedy systemic IFNgamma and TNFalpha caused by anti-CD40, but CB2-mediated suppression of APCs by THC quenches pathogenic release of IL-22 and IL-17A in the colon. Dronabinol 0-3 interferon gamma Homo sapiens 51-59 32493779-1 2020 QuantiFERON-TB Gold Plus (QFT-Plus) is the latest generation of interferon-gamma release assays (IGRAs) to receive approval from the US FDA, replacing its predecessor QuantiFERON-TB Gold In-Tube (QFT-GIT). quantiferon-tb gold plus 0-24 interferon gamma Homo sapiens 64-80 32493779-1 2020 QuantiFERON-TB Gold Plus (QFT-Plus) is the latest generation of interferon-gamma release assays (IGRAs) to receive approval from the US FDA, replacing its predecessor QuantiFERON-TB Gold In-Tube (QFT-GIT). quantiferon-tb gold 0-19 interferon gamma Homo sapiens 64-80 32878107-4 2020 BCU decreased the serum concentration of IgG, IL-2, IFN-gamma, and IgA in DON treated piglets (p < 0.05), and promoted the serum concentration of IL-1beta, IgG, IL-2, IFN-gamma, IgA, IL-6, IgM, and TNFalpha in normal piglets (p < 0.05). (3r)-3,4-Dihydro-2h-Chromen-3-Ylmethanol 0-3 interferon gamma Homo sapiens 52-61 32878107-4 2020 BCU decreased the serum concentration of IgG, IL-2, IFN-gamma, and IgA in DON treated piglets (p < 0.05), and promoted the serum concentration of IL-1beta, IgG, IL-2, IFN-gamma, IgA, IL-6, IgM, and TNFalpha in normal piglets (p < 0.05). (3r)-3,4-Dihydro-2h-Chromen-3-Ylmethanol 0-3 interferon gamma Homo sapiens 167-176 32706371-18 2020 The production of IFN-gamma, a type II IFN, was decreased in patients in response to stimulation with imiquimod. Imiquimod 102-111 interferon gamma Homo sapiens 18-27 32497931-4 2020 These results suggest imbalanced Tfh cell regulation, further supported by increased frequencies of CD4 T cells co-producing IL-21/IL-17 and IL-17/IFN-gamma, and increased Tfh-supported IgG production. tfh 33-36 interferon gamma Homo sapiens 147-156 32631539-2 2020 In vitro immunosuppressive assay showed that 10alpha-dihydroartemisinin-beta-O-d-mannoside (19a) demonstrate 88% inhibition towards T cells proliferation and 98% reduction in IFN-gamma levels in cell media. 10alpha-dihydroartemisinin-beta-o-d-mannoside 45-90 interferon gamma Homo sapiens 175-184 32923162-8 2020 Maraviroc could partly reduce IFN-gamma secretion by CCR5+TINs (P< .001). Maraviroc 0-9 interferon gamma Homo sapiens 30-39 32823923-6 2020 After anti-TB treatment, increased levels of perforin, granulysin and IFN-gamma in TB or HIV/TB upon PPD or H37Ra stimulation, and decreased granzyme-B levels after PPD (p = 0.003) or H37Ra (p = 0.028) stimulation in TB were observed. h37ra 108-113 interferon gamma Homo sapiens 70-79 32641388-4 2020 In this study, we report that metformin + 2-DG treatment more potently suppressed IFN-gamma production and cell proliferation in activated primary human CD4+ T cells than either metformin or 2-DG treatment alone. Metformin 30-39 interferon gamma Homo sapiens 82-91 32641388-4 2020 In this study, we report that metformin + 2-DG treatment more potently suppressed IFN-gamma production and cell proliferation in activated primary human CD4+ T cells than either metformin or 2-DG treatment alone. Deoxyglucose 42-46 interferon gamma Homo sapiens 82-91 32923162-11 2020 Our results indicate that CCR5+TINs could prime anti-tumor immune response through autonomous IFN-gamma release, thus leading to favorable prognosis and superior therapeutic response to ACT and immunotherapy in MIBC. 4-METHYL-2-PENTANOL 211-215 interferon gamma Homo sapiens 94-103 32923162-8 2020 Maraviroc could partly reduce IFN-gamma secretion by CCR5+TINs (P< .001). tins 58-62 interferon gamma Homo sapiens 30-39 32923162-11 2020 Our results indicate that CCR5+TINs could prime anti-tumor immune response through autonomous IFN-gamma release, thus leading to favorable prognosis and superior therapeutic response to ACT and immunotherapy in MIBC. tins 31-35 interferon gamma Homo sapiens 94-103 32818210-5 2020 Elovanoid (ELV)-N32 or Resolvin D6-isomer (RvD6i), among the lipid mediators studied, consistently decreased the expression of the ACE2 receptor, furin, and integrins in damaged corneas or IFNgamma stimulated human corneal epithelial cells (HCEC). elovanoid 0-9 interferon gamma Homo sapiens 189-197 32781843-6 2021 Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha). diphtheria toxin fragment A 21-24 interferon gamma Homo sapiens 256-283 32781843-6 2021 Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha). dda 13-16 interferon gamma Homo sapiens 256-283 32818210-5 2020 Elovanoid (ELV)-N32 or Resolvin D6-isomer (RvD6i), among the lipid mediators studied, consistently decreased the expression of the ACE2 receptor, furin, and integrins in damaged corneas or IFNgamma stimulated human corneal epithelial cells (HCEC). elvitegravir 11-14 interferon gamma Homo sapiens 189-197 32781018-13 2020 Our data indicate that Interferon-gamma-induced kynurenine pathway promotes human decidualization via aryl hydrocarbon receptor signaling. Kynurenine 48-58 interferon gamma Homo sapiens 23-39 31991045-0 2020 Monitoring of CMV-specific cell-mediated immunity with a commercial ELISA-based interferon-gamma release assay in kidney transplant recipients treated with antithymocyte globulin. Antilymphocyte Serum 156-178 interferon gamma Homo sapiens 80-96 32848386-9 2020 In vitro, CYPP-PEI nanoparticles promoted antigen uptake, enhanced surface molecular expressions of CD80 and CD86, and improved cytokine secretion of TNF-alpha, IFN-gamma, and IL-12p70 in macrophages. cypp-pei 10-18 interferon gamma Homo sapiens 161-170 32817992-4 2020 Results Tacrolimus significantly increased the expression of LIF, IL-10, and IL-17 and decreased the expression of IL-4, IFN-gamma, and the IFN-gamma/IL-10 ratio in RIF patients. Tacrolimus 8-18 interferon gamma Homo sapiens 121-130 32302669-3 2020 In this study, by using live cell imaging and biochemical approaches, we demonstrate that IFN-gamma plus high glucose augment endothelial connexin43 hemichannel activity, resulting in the increase of ATP release, ATP-mediated Ca2+ dynamics and production of nitric oxide and superoxide anion, as well as impaired insulin-mediated uptake and intercellular diffusion of glucose and cell survival. Adenosine Triphosphate 200-203 interferon gamma Homo sapiens 90-99 32302669-3 2020 In this study, by using live cell imaging and biochemical approaches, we demonstrate that IFN-gamma plus high glucose augment endothelial connexin43 hemichannel activity, resulting in the increase of ATP release, ATP-mediated Ca2+ dynamics and production of nitric oxide and superoxide anion, as well as impaired insulin-mediated uptake and intercellular diffusion of glucose and cell survival. Adenosine Triphosphate 213-216 interferon gamma Homo sapiens 90-99 32302669-3 2020 In this study, by using live cell imaging and biochemical approaches, we demonstrate that IFN-gamma plus high glucose augment endothelial connexin43 hemichannel activity, resulting in the increase of ATP release, ATP-mediated Ca2+ dynamics and production of nitric oxide and superoxide anion, as well as impaired insulin-mediated uptake and intercellular diffusion of glucose and cell survival. Nitric Oxide 258-270 interferon gamma Homo sapiens 90-99 32302669-3 2020 In this study, by using live cell imaging and biochemical approaches, we demonstrate that IFN-gamma plus high glucose augment endothelial connexin43 hemichannel activity, resulting in the increase of ATP release, ATP-mediated Ca2+ dynamics and production of nitric oxide and superoxide anion, as well as impaired insulin-mediated uptake and intercellular diffusion of glucose and cell survival. Superoxides 275-291 interferon gamma Homo sapiens 90-99 32302669-3 2020 In this study, by using live cell imaging and biochemical approaches, we demonstrate that IFN-gamma plus high glucose augment endothelial connexin43 hemichannel activity, resulting in the increase of ATP release, ATP-mediated Ca2+ dynamics and production of nitric oxide and superoxide anion, as well as impaired insulin-mediated uptake and intercellular diffusion of glucose and cell survival. Glucose 368-375 interferon gamma Homo sapiens 90-99 32408215-0 2020 Corrigendum to "N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-gamma induced PD-L1 expression"[Eur. n-alkyl-hydroxybenzoyl anilide hydroxamates 16-59 interferon gamma Homo sapiens 113-122 32682346-10 2020 CONCLUSION: Our results suggest impaired Tregs suppressive function in GV patients due to decreased NFATC1, FOXP3, CD25, IL-10 & TGF-beta resulting into increased CD8+ and CD4+ T cell proliferation and IFN-gamma production. tregs 41-46 interferon gamma Homo sapiens 202-211 32439507-10 2020 CsA may inhibit T-helper 1 (Th1) cells and consequently IFNgamma production, causing a synergetic effect with Dex on virus reactivation. Cyclosporine 0-3 interferon gamma Homo sapiens 56-64 32446944-8 2020 By contrast, TLR4+IFN-gamma receptor stimulation mainly resulted in complex IV inhibition by nitric oxide (NO) that also associated with severe oxidative stress, neuronal dysfunction and death. Nitric Oxide 93-105 interferon gamma Homo sapiens 18-27 32536506-8 2020 Fresh EA NK cells generated high levels of gamma interferon (IFN-gamma), which was abrogated by JAK1/JAK2 inhibition with ruxolitinib, but C/T EA NK cells showed lower IFN-gamma unaffected by JAK1/JAK2 inhibition. ruxolitinib 122-133 interferon gamma Homo sapiens 43-70 32536506-8 2020 Fresh EA NK cells generated high levels of gamma interferon (IFN-gamma), which was abrogated by JAK1/JAK2 inhibition with ruxolitinib, but C/T EA NK cells showed lower IFN-gamma unaffected by JAK1/JAK2 inhibition. ruxolitinib 122-133 interferon gamma Homo sapiens 61-70 32267089-0 2020 Anti-viral activity of jatrophone against RSV-induced respiratory infection via increase in interferon-gamma generating dendritic cells. jatrophone 23-33 interferon gamma Homo sapiens 92-108 32267089-11 2020 Flow cytometry revealed elevated count of IFN-gamma generating cells in RSV infected mice on treatment with jatrophone. jatrophone 108-118 interferon gamma Homo sapiens 42-51 32817992-4 2020 Results Tacrolimus significantly increased the expression of LIF, IL-10, and IL-17 and decreased the expression of IL-4, IFN-gamma, and the IFN-gamma/IL-10 ratio in RIF patients. Tacrolimus 8-18 interferon gamma Homo sapiens 140-149 32470879-8 2020 Moreover, CCSC vaccine resulted in the elevated NK cytotoxicity, production of perforin, granzyme B, IFN-gamma, memory B cells, and anti-MUC1 antibodies. ccsc 10-14 interferon gamma Homo sapiens 101-110 32847986-11 2020 CD38hi macrophages produce more interferon gamma (IFN-gamma) and related cytokines, which may explain its predictive value when treated with ICB. indole-2-carboxylic acid 141-144 interferon gamma Homo sapiens 32-59 32334890-1 2020 In 2016, a new interferon-gamma release assay, QuantiFERON-TB Gold Plus, was introduced. quantiferon-tb gold 47-66 interferon gamma Homo sapiens 15-31 32330348-5 2020 We report herein that vemurafenib downregulates IFN-gamma-induced PD-L1 expression by interfering with STAT1 activity and by decreasing PD-L1 protein translation. Vemurafenib 22-33 interferon gamma Homo sapiens 48-57 32669430-6 2020 Moreover, the cHAmg vaccine combined with a glycolipid adjuvant designed for class switch further enhanced the vaccine efficacy with more IFN-gamma, IL-4, and CD8+ memory T cells produced. Glycolipids 44-54 interferon gamma Homo sapiens 138-147 33040814-0 2020 Effects of oral desloratadine citrate disodium combined with physiological seawater nasal irrigation on IgE levels, IL-4, IL-6, IL-13 and IFN-gamma expression and treatment of intermittent allergic rhinitis. desloratadine citrate disodium 16-46 interferon gamma Homo sapiens 138-147 32323514-8 2020 In addition, MSCs increased PGE2 production after TNF-alpha/IFN-gamma stimulation, with the highest increase observed in MSC/SOCS1sh co-culture. Dinoprostone 28-32 interferon gamma Homo sapiens 60-69 32686067-5 2020 Furthermore, the hIFN-gamma (with and without ELP) accumulated to higher levels in the endoplasmic reticulum. ELP 46-49 interferon gamma Homo sapiens 17-27 32720695-8 2021 The loss of QGIT positivity during pregnancy was explained by decreased IFNgamma production in response to TB antigen and/or mitogen. Terbium 107-109 interferon gamma Homo sapiens 72-80 32944181-7 2020 Pre- or post-treatment with LEVs under inflammatory M1 macrophage-favouring conditions, induced by LPS and interferon-gamma, inhibited M1-associated surface marker, HLA-DRalpha expression. levs 28-32 interferon gamma Homo sapiens 107-123 32793196-11 2020 In addition, Vgamma2Vdelta2 T cells secreted interferon-gamma (IFN-gamma) when challenged by lung cancer cell lines pulsed with PTA in a dose-dependent manner. tetrakispivaloyloxymethyl 2-(thiazole-2-ylamino)ethylidene-1,1-bisphosphonate 128-131 interferon gamma Homo sapiens 45-61 32793196-11 2020 In addition, Vgamma2Vdelta2 T cells secreted interferon-gamma (IFN-gamma) when challenged by lung cancer cell lines pulsed with PTA in a dose-dependent manner. tetrakispivaloyloxymethyl 2-(thiazole-2-ylamino)ethylidene-1,1-bisphosphonate 128-131 interferon gamma Homo sapiens 63-72 32698510-12 2020 Ruxolitinib reverted IFN-gamma-induced expression of caspase-1, IL-1beta, IL-15, and IL-18, and stimulated several growth factors, such as FGF7. ruxolitinib 0-11 interferon gamma Homo sapiens 21-30 32698510-14 2020 Ruxolitinib pretreatment showed a protective effect on IFN-gamma-induced expression of MHC-class II molecules in cultured hair follicles. ruxolitinib 0-11 interferon gamma Homo sapiens 55-64 32698510-17 2020 Ruxolitinib treatment prevented IFN-gamma-induced collapse of hair-follicle immune privilege. ruxolitinib 0-11 interferon gamma Homo sapiens 32-41 32709035-10 2020 Conclusions: Our results suggest the presence of molecular stages of PA, defined according to the over-expression (first stage) or under-expression (second stage) of the HMOX1, SOD1, IL-6, and IFNgamma genes in abnormal skin tissue. Protactinium 69-71 interferon gamma Homo sapiens 193-201 32652996-13 2020 Hybridization with 32P-labelled oligonucleotides showed that the IBs contain rRNA and are enriched of hIFNgamma mRNA. Phosphorus-32 19-22 interferon gamma Homo sapiens 102-111 32674502-6 2020 In addition, PCG significantly decreased PAR2-induced increases in ICAM-1 and VCAM-1 as well as in IL-8, IFN-gamma, and TNF-alpha expression. punicalagin 13-16 interferon gamma Homo sapiens 105-114 32238729-4 2020 Administration of steroid and high-dose intravenous immunoglobulin (1 g/kg) did not alleviate fever or reduce cytokine production; however, after administration of etoposide (an antineoplastic agent), fever decreased immediately, the patient"s general condition improved, and levels of IL-6, IL-10, IL-8, MCP-1, IFN-gamma, and TNF-alpha declined after etoposide administration. Etoposide 164-173 interferon gamma Homo sapiens 312-321 31722386-0 2020 A Single Haplotype of IFNG Correlating With Low Circulating Levels of Interferon-gamma Is Associated With Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis. Interferon-gamma 70-86 interferon gamma Homo sapiens 22-26 31722386-1 2020 BACKGROUND: Interferon-gamma (IFN-gamma) plays an important role in the control of Leishmania infection. Interferon-gamma 12-28 interferon gamma Homo sapiens 30-39 32694530-7 2020 IFNG and IL12 expressions significantly decreased (p < 0.001) in cells treated with CQ and CQ NPs at 24 and 48 h compared to NT. Chloroquine 84-86 interferon gamma Homo sapiens 0-4 32694530-7 2020 IFNG and IL12 expressions significantly decreased (p < 0.001) in cells treated with CQ and CQ NPs at 24 and 48 h compared to NT. Chloroquine 91-93 interferon gamma Homo sapiens 0-4 31036393-11 2020 CONCLUSION: Plant derived essential oils and related active compounds have potential therapeutic activity for the treatment of asthma by modulating the release of pro-inflammatory (TNF-alpha, IL-1beta, IL-8), Th17 (IL-17), anti-inflammatory (IL-10), Th1 (IFN-gamma, IL-2, IL-12) and Th2 (IL-4, IL-5, IL-6, IL-13) cytokines and the suppression of inflammatory cell accumulation. Oils, Volatile 26-40 interferon gamma Homo sapiens 255-264 32764938-8 2020 Results: beta-glucan nanoparticles can activate macrophages to produce immune enhancing cytokines (IL-1beta, IL-6, TNF-alpha, IFN-gamma). beta-Glucans 9-20 interferon gamma Homo sapiens 126-135 31722386-6 2020 METHODS: We assessed 9 SNP and cytosine-adenine (CA) repeats in IFNG by nucleotide sequencing in 647 patients with CL caused by Leishmania guyanensis and 629 controls. Cytosine 31-47 interferon gamma Homo sapiens 64-68 32652996-13 2020 Hybridization with 32P-labelled oligonucleotides showed that the IBs contain rRNA and are enriched of hIFNgamma mRNA. Oligonucleotides 32-48 interferon gamma Homo sapiens 102-111 32122920-7 2020 DNAJB7-specific T cells were capable of killing colorectal tumor lines in vitro, and the IFN-g+ response was markedly magnified by control of immunosuppression with cyclophosphamide in cancer patients. Cyclophosphamide 165-181 interferon gamma Homo sapiens 89-94 32695877-6 2020 We established IFN-g and IL-13 responses involved STAT dependent pathways, and STAT targeting (tofacitinib) could inhibit IL-13 production from mast cells, IL-13Ra1 up-regulation in fibroblasts and fibroproliferative effects of IL-13 on diseased myofibroblasts. tofacitinib 95-106 interferon gamma Homo sapiens 15-20 32620811-5 2020 The intracellular uptake of cytosine-phosphate-guanine (CpG) promoted the infiltration of cytotoxic T lymphocytes (CTLs) in tumor tissue, further stimulating the production of interferon gamma (IFN-gamma) and remarkably elevating the immune response level. cytosine-phosphate-guanine 28-54 interferon gamma Homo sapiens 176-203 32277536-6 2020 The percentage of IFN-gamma- or TNF-alpha-producing Th cells was significantly increased in VDI or vitamin D deficiency group (VDD) when compared with VDN (P < 0.05 each). Vitamin D 99-108 interferon gamma Homo sapiens 18-27 32533334-11 2020 Furthermore, IFNgamma expression appeared to be increased in response to metformin (p = 0.08). Metformin 73-82 interferon gamma Homo sapiens 13-21 32265223-2 2020 Of note, in response to IFNgamma, M-MDSCs release the tumor-promoting and immunosuppressive molecule nitric oxide (NO), whereas macrophages largely express antitumor properties. Nitric Oxide 101-113 interferon gamma Homo sapiens 24-32 32265223-3 2020 Investigating these opposing activities, we found that tumor-derived prostaglandin E2 (PGE2) induces nuclear accumulation of p50 NF-kappaB in M-MDSCs, diverting their response to IFNgamma toward NO-mediated immunosuppression and reducing TNFalpha expression. Dinoprostone 69-85 interferon gamma Homo sapiens 179-187 32265223-3 2020 Investigating these opposing activities, we found that tumor-derived prostaglandin E2 (PGE2) induces nuclear accumulation of p50 NF-kappaB in M-MDSCs, diverting their response to IFNgamma toward NO-mediated immunosuppression and reducing TNFalpha expression. Dinoprostone 87-91 interferon gamma Homo sapiens 179-187 32265223-7 2020 SIGNIFICANCE: Tumor-derived PGE2-mediated induction of nuclear p50 NF-kappaB epigenetically reprograms the response of monocytic cells to IFNgamma toward an immunosuppressive phenotype, thus retrieving the anticancer properties of IFNgamma. Dinoprostone 28-32 interferon gamma Homo sapiens 138-146 32265223-7 2020 SIGNIFICANCE: Tumor-derived PGE2-mediated induction of nuclear p50 NF-kappaB epigenetically reprograms the response of monocytic cells to IFNgamma toward an immunosuppressive phenotype, thus retrieving the anticancer properties of IFNgamma. Dinoprostone 28-32 interferon gamma Homo sapiens 231-239 32475317-9 2020 After in vitro incubation of placental arteries with IDO1-upregulating cytokines interferon-gamma and tumor necrosis factor-alpha, l-tryptophan induced vasodilation. Tryptophan 131-143 interferon gamma Homo sapiens 81-129 32398245-1 2020 OBJECTIVES: Oxidised cholesterol metabolites are linked to increased production of the active vitamin A (Vit-A) form and monocyte/macrophage activation, which may be reflected by neopterin, a marker of both interferon-gamma-mediated immune activation and coronary artery disease risk. Cholesterol 21-32 interferon gamma Homo sapiens 207-223 32339714-4 2020 RESULTS: In HIV uninfected patients TSPOT.TB and QFT-GIT IFN-gamma responses were 5-fold (p < 0.01) and 2-fold higher (p < 0.05) for those infected with family 33 compared to the LAM strain (additionally, TSPOT.TB responses were 5.6-fold (p < 0.05) and 2.6-fold higher (p < 0.05) for the patients infected with the family 33 versus the X strain and Beijing versus the LAM strain, respectively). lipoarabinomannan 179-182 interferon gamma Homo sapiens 57-66 32339714-2 2020 METHODS: We evaluated the IFN-gamma responses (QuantiFERON-TB Gold-In-Tube (QFT-GIT) TSPOT-TB) stratified according to the M.tb spoligotype of the culture isolate obtained from the same patients with confirmed active TB (n = 91). Terbium 59-61 interferon gamma Homo sapiens 26-35 32339714-4 2020 RESULTS: In HIV uninfected patients TSPOT.TB and QFT-GIT IFN-gamma responses were 5-fold (p < 0.01) and 2-fold higher (p < 0.05) for those infected with family 33 compared to the LAM strain (additionally, TSPOT.TB responses were 5.6-fold (p < 0.05) and 2.6-fold higher (p < 0.05) for the patients infected with the family 33 versus the X strain and Beijing versus the LAM strain, respectively). Terbium 211-213 interferon gamma Homo sapiens 57-66 32339714-4 2020 RESULTS: In HIV uninfected patients TSPOT.TB and QFT-GIT IFN-gamma responses were 5-fold (p < 0.01) and 2-fold higher (p < 0.05) for those infected with family 33 compared to the LAM strain (additionally, TSPOT.TB responses were 5.6-fold (p < 0.05) and 2.6-fold higher (p < 0.05) for the patients infected with the family 33 versus the X strain and Beijing versus the LAM strain, respectively). lipoarabinomannan 368-371 interferon gamma Homo sapiens 57-66 33095140-10 2020 CONCLUSIONS: Kynurenines are biomarkers of greater adipose infiltration in LSGB and glandular dysfunction suggesting that activation of interferon-gamma pathway is involved in the salivary and lacrimal glands damage. Kynurenine 13-24 interferon gamma Homo sapiens 136-152 32360883-8 2020 Further flow cytometry analysis showed that ESAT-6 stimulation induced a significantly higher mean fluorescence intensity of IFN-gamma+ cells in lymphocytes compared with culture filtrate protein 10 (CFP-10) stimulation. esat-6 44-50 interferon gamma Homo sapiens 125-134 33099927-6 2020 Inhibition of the MAPK pathway by EGFR inhibitors ositinib or MEK 1 and 2 inhibitors selumetinib prevented the up-regulation of CD274 mRNA and PD-L1 proteins and membranes induced by EGF and IFN-gamma. AZD 6244 85-96 interferon gamma Homo sapiens 191-200 32492985-0 2020 The Dose Dependent Effects of Ruxolitinib on the Invasion and Tumorigenesis in Gliomas Cells via Inhibition of Interferon Gamma-Depended JAK/STAT Signaling Pathway. ruxolitinib 30-41 interferon gamma Homo sapiens 111-127 32492985-3 2020 This study aimed to determine the dose-dependent effects of ruxolitinib, an inhibitor of JAK, on the interferon (IFN)-I/IFN-alpha/IFN-beta receptor/STAT and IFN-gamma/IFN-gamma receptor/STAT1 axes of the IFN-receptor-dependent JAK/STAT signaling pathway in glioblastoma invasion and tumorigenesis in U87 glioblastoma tumor spheroids. ruxolitinib 60-71 interferon gamma Homo sapiens 157-166 32492985-6 2020 Results: Quantitative real-time polymerase chain reaction analysis demonstrated that ruxolitinib led to upregulated of the IFN-alpha and IFN-gamma while no change on the hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression levels. ruxolitinib 85-96 interferon gamma Homo sapiens 137-146 32360883-9 2020 In contrast, CFP-10 stimulation induced a significantly higher percentage of IFN-gamma+ cells in lymphocytes compared with ESAT-6 stimulation. cfp-10 13-19 interferon gamma Homo sapiens 77-86 32492985-10 2020 Conclusion: Collectively, our results revealed that ruxolitinib may have therapeutic potential in glioblastomas, possibly by JAK/STAT signaling triggered by IFN-alpha and IFN-gamma. ruxolitinib 52-63 interferon gamma Homo sapiens 171-180 32724457-11 2020 Moreover, CQ enhanced CTLA-4 expression in activated human T cells and reduced the secretion of IFN-gamma in human mixed lymphocyte reaction. Chloroquine 10-12 interferon gamma Homo sapiens 96-105 32590737-6 2020 In addition, ATO significantly reduced the levels of IFN-gamma (at 1, 2.5 and 5 mumol/L, P < .001), IL-4 (at 2.5 mumol/L, P = .009; at 5 mumol/L, P < .001), and IL-17 (at 2.5, P = .016; at 5 mumol/L, P < .001). Arsenic Trioxide 13-16 interferon gamma Homo sapiens 53-62 32591520-5 2020 In interferon-gamma (IFNgamma) stimulated cells, PhosID enabled the identification of a large number of IFN responsive newly synthesized proteins (NSPs) whereby we monitored the differential synthesis of these proteins over time. phosid 49-55 interferon gamma Homo sapiens 3-19 32591520-5 2020 In interferon-gamma (IFNgamma) stimulated cells, PhosID enabled the identification of a large number of IFN responsive newly synthesized proteins (NSPs) whereby we monitored the differential synthesis of these proteins over time. phosid 49-55 interferon gamma Homo sapiens 21-29 32584968-3 2021 METHODS: We used a model of TB transmission to estimate the numbers of individuals who could be tested by interferon-gamma release assay (IGRA) and treated for LTBI with three months of self-administered rifapentine and isoniazid (3HP) under various TTT scenarios. Terbium 28-30 interferon gamma Homo sapiens 106-122 31429907-10 2020 Overall, anti-IFN-gamma autoantibody levels decreased over time in Thailand (P<0.001) and the US (P=0.017), as well as with cyclophosphamide (P=0.01) and rituximab therapy (P=0.001). Cyclophosphamide 127-143 interferon gamma Homo sapiens 14-23 32694973-6 2020 Inflammatory inducible KYN and BH4 pathways upregulation is characterized by increase in pronociceptive compounds, such as quinolinic acid (QUIN) and BH4, in addition to inflammatory mediators such as interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha). sapropterin 31-34 interferon gamma Homo sapiens 201-228 32568409-4 2020 During early treatment with peg-IFN-a2a plus ribavirin, the imbalance of these Tc17/IFN-gamma cells could be partially restored, together with normalized serum ALT but not AST. Ribavirin 45-54 interferon gamma Homo sapiens 84-93 32695149-5 2020 Cysteine residues located in the zinc finger regions (amino acid fragments AA 90-115, AA 116-130, and AA 160-167) of PPARgamma were highly oxidized, accompanied by phosphorylation of serine 82 in response to LPS/IFNgamma, whereas IL4-stimulation provoked minor serine 82 phosphorylation and less cysteine oxidation, favoring a reductive milieu. Cysteine 0-8 interferon gamma Homo sapiens 212-220 32726007-11 2020 Compared with the model control group, high and low-dose Chaiyin Particles significantly increased cross blood CD4~+ T lymphocytes, CD8~+T lymphocytes and total B lymphocyte percentage(P<0.05, P<0.01), and reduced IL-10, TNF-alpha and IFN-gamma levels in lungs(P<0.01). chaiyin 57-64 interferon gamma Homo sapiens 235-244 32670280-16 2020 Inhibition of mTOR in purified NK cells from healthy donors by rapamycin decreased the synthesis of IFN-gamma. Sirolimus 63-72 interferon gamma Homo sapiens 100-109 32581238-6 2020 Induction of HO-1 by hemin or CoPP in vitro reduced production of IFN-gamma and IL-10 from healthy human PBMCs and decreased bacterial clearance activity of whole blood from healthy controls and beta-thalassaemia, while inhibition of HO-1 by SnPP enhanced both functions in healthy controls. Hemin 21-26 interferon gamma Homo sapiens 66-75 32581238-6 2020 Induction of HO-1 by hemin or CoPP in vitro reduced production of IFN-gamma and IL-10 from healthy human PBMCs and decreased bacterial clearance activity of whole blood from healthy controls and beta-thalassaemia, while inhibition of HO-1 by SnPP enhanced both functions in healthy controls. COPP protocol 30-34 interferon gamma Homo sapiens 66-75 32247228-2 2020 Following DMF therapy, LTalpha+, TNFalpha+ and IFNgamma+ B cells were reduced while TGFbeta and IL10 expression elevated. Dimethyl Fumarate 10-13 interferon gamma Homo sapiens 47-55 32031616-8 2020 Spermidine suppressed IFN-gamma-induced STAT1 and STAT3 phosphorylation, along with decreased mRNA expression of ICAM-1, NOD2, and IFNG in IECs and monocytes. Spermidine 0-10 interferon gamma Homo sapiens 131-135 32714765-4 2020 Structural analyses reveal stronger affinity between alpha-GalCer-diol and cluster of differentiation 1d (CD1d), leading to enhanced antigen presentation by dendritic cells (DCs) and self-activation, as reflected by tight binding of the T-cell receptor (TCR)/KRN7000/CD1d ternary complex and elevated production of interleukin 12 (IL-12) and interferon-gamma (IFN-gamma). alpha-galcer-diol 53-70 interferon gamma Homo sapiens 342-358 32418798-7 2020 Advax-adjuvanted VLPs induced a stronger IFN-gamma, TNF and IL-12 signature and serum transferred from Advax-adjuvanted vaccinees was able to transfer protection to naive animals, showing that Ebola protection can be achieved by antibodies in the absence of cellular immunity. delta inulin 0-5 interferon gamma Homo sapiens 41-50 32532298-10 2020 In vitro, IFNgamma stimulation enhanced iP expression, reduced reactive oxygen species burden, and decreased oxidatively damaged and poly-ubiquitinated protein accumulation preferentially in human spinal cord astrocytes, which was abrogated with the use of the iP inhibitor, ONX 0914. Oxygen 72-78 interferon gamma Homo sapiens 10-18 32532298-10 2020 In vitro, IFNgamma stimulation enhanced iP expression, reduced reactive oxygen species burden, and decreased oxidatively damaged and poly-ubiquitinated protein accumulation preferentially in human spinal cord astrocytes, which was abrogated with the use of the iP inhibitor, ONX 0914. PR-957 275-283 interferon gamma Homo sapiens 10-18 32724650-4 2020 The results showed that serum concentrations of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and total Th1 cytokines were positively associated with serum beta-sitosterol level, adjusting for age, BMI, and serum cholesterol. gamma-sitosterol 169-184 interferon gamma Homo sapiens 48-70 32724650-5 2020 Serum IFN-gamma and total Th1 cytokine concentrations positively correlated with total phytosterol concentration, controlling age, BMI, and serum cholesterol. Phytosterols 87-98 interferon gamma Homo sapiens 6-15 32724650-5 2020 Serum IFN-gamma and total Th1 cytokine concentrations positively correlated with total phytosterol concentration, controlling age, BMI, and serum cholesterol. Cholesterol 146-157 interferon gamma Homo sapiens 6-15 32521784-3 2020 The artificial in vitro activation of CD4+ T lymphocytes by a combination of 12-O-tetradecanoylphorbol-13-acetate and ionomycin, the so-called T/I model, led to an inducible production of cytokines, such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-2. Ionomycin 118-127 interferon gamma Homo sapiens 207-223 32564053-7 2020 RESULTS Compared with the healthy controls, the serum expression of IL-18, IL-33, IFN-gamma, IL-5, IL-6, IL-8, and IL-13 were significantly higher in the MPP and NMPP groups. nmpp 162-166 interferon gamma Homo sapiens 82-91 32521784-3 2020 The artificial in vitro activation of CD4+ T lymphocytes by a combination of 12-O-tetradecanoylphorbol-13-acetate and ionomycin, the so-called T/I model, led to an inducible production of cytokines, such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-2. Tetradecanoylphorbol Acetate 77-113 interferon gamma Homo sapiens 207-223 32714765-6 2020 Different from KRN7000, alpha-GalCer-diol markedly boosts the expansion of the CD11b+ subpopulation and enhances IFN-gamma content in CD11b+ cells. alpha-galcer-diol 24-41 interferon gamma Homo sapiens 113-122 32714765-4 2020 Structural analyses reveal stronger affinity between alpha-GalCer-diol and cluster of differentiation 1d (CD1d), leading to enhanced antigen presentation by dendritic cells (DCs) and self-activation, as reflected by tight binding of the T-cell receptor (TCR)/KRN7000/CD1d ternary complex and elevated production of interleukin 12 (IL-12) and interferon-gamma (IFN-gamma). alpha-galcer-diol 53-70 interferon gamma Homo sapiens 360-369 32273087-5 2020 Accordingly, oral administration of galangin significantly ameliorated airway hyperresponsiveness, inflammation and goblet cell hyperplasia by the suppression of IL-4, 5, 13, 17, TNF-alpha, NO, ROS, EPO, IgE and increase of IFN-gamma in ovalbumin-induced allergic asthma model. galangin 36-44 interferon gamma Homo sapiens 224-233 32512720-6 2020 WGPH treatment reduced cell proliferation and the production of the Type 1 T helper (Th1) and Th17 pro-inflammatory cytokines IFN-gamma and IL-17, respectively. wgph 0-4 interferon gamma Homo sapiens 126-135 32670763-5 2020 Biomarker analysis indicates upregulation of the proinflammation cytokines TNF-alpha, IL-6, IL-10, MIP-1, MCP-1, and RANTES in response to LPS + IFN-gamma treatment indicative of the M1 macrophage phenotype, whereas amiodarone treatment only leads to an increase in the restorative cytokine IL-6 which is a marker for the M2 phenotype. Amiodarone 216-226 interferon gamma Homo sapiens 145-154 32410446-3 2020 In this work, we designed a conjugated anti- interferon-gamma (IFN-gamma) molecular aptamer beacon (MAB) attached to a bioluminescent protein, Gaussia luciferase (GLuc), and an inhibitor molecule with a similar structure to the native substrate coelenterazine. coelenterazine 245-259 interferon gamma Homo sapiens 45-61 32410446-3 2020 In this work, we designed a conjugated anti- interferon-gamma (IFN-gamma) molecular aptamer beacon (MAB) attached to a bioluminescent protein, Gaussia luciferase (GLuc), and an inhibitor molecule with a similar structure to the native substrate coelenterazine. coelenterazine 245-259 interferon gamma Homo sapiens 63-72 31610228-12 2020 CONCLUSION: Patients with alcohol overconsumption had a cytokine profile suggestive of increased systemic inflammatory activity, with higher levels of pro-inflammatory cytokines (IL-6, IFN-gamma and MCP-1) and lower levels of anti-inflammatory cytokines (TGF-beta1). Ethanol 26-33 interferon gamma Homo sapiens 185-194 32420456-2 2020 Interferon-gamma (IFN-gamma) is elevated during malaria infection and is thought to influence erythropoiesis and iron status. Iron 113-117 interferon gamma Homo sapiens 0-16 32420456-2 2020 Interferon-gamma (IFN-gamma) is elevated during malaria infection and is thought to influence erythropoiesis and iron status. Iron 113-117 interferon gamma Homo sapiens 18-27 32420456-4 2020 We investigated putative functional single nucleotide polymorphisms (SNPs) and haplotypes of IFNG in relation to nutritional iron status and anaemia in Gambian children over a malaria season. Iron 125-129 interferon gamma Homo sapiens 93-97 31610228-8 2020 Patients with alcohol overconsumption had higher levels of IL-6 (p = 0.002), IFN-gamma (p = 0.018) and MCP-1 (p = 0.006), and lower levels of TGF-beta1 (p = 0.017) compared with control patients. Ethanol 14-21 interferon gamma Homo sapiens 77-86 32227269-9 2020 Furthermore, levels of PFOA were inversely associated with the interferon gamma (IFNgamma) production of ex-vivo lymphocytes after stimulation with tetanus and diphtheria toxoid, with an effect size of - 64 and - 59% (means Q1 vs. Q5), respectively. perfluorooctanoic acid 23-27 interferon gamma Homo sapiens 63-90 32487617-3 2020 RESULTS: EvCAR-KHYG-1 cells produced interleukin-2, interferon-gamma, and tumour necrosis factor-alpha on EGFRvIII-expressing U87MG cells. evcar 9-14 interferon gamma Homo sapiens 52-68 32199179-5 2020 RESULTS: The mean IL-4 production from HCF-Ag stimulated PBMCs was significantly decreased (p < 0.05), while IFN-gamma was significantly increased in HCF-Ag stimulated PBMCs in patients after surgery (p = 0.005). hcf-ag 150-156 interferon gamma Homo sapiens 109-118 32078695-8 2020 Cisplatin, 5-fluorouracil and carboplatin induced dose-dependent apoptosis in primary lines of iNKT cells and inhibited CD1d-dependent interferon-gamma production and cytolytic degranulation by viable iNKT cells. Cisplatin 0-9 interferon gamma Homo sapiens 135-151 32078695-8 2020 Cisplatin, 5-fluorouracil and carboplatin induced dose-dependent apoptosis in primary lines of iNKT cells and inhibited CD1d-dependent interferon-gamma production and cytolytic degranulation by viable iNKT cells. Fluorouracil 11-25 interferon gamma Homo sapiens 135-151 32078695-8 2020 Cisplatin, 5-fluorouracil and carboplatin induced dose-dependent apoptosis in primary lines of iNKT cells and inhibited CD1d-dependent interferon-gamma production and cytolytic degranulation by viable iNKT cells. Carboplatin 30-41 interferon gamma Homo sapiens 135-151 32199179-8 2020 While, production of IFN-gamma was increased significantly in responses to HCF Ag after surgery. 2-hydroxy-N-(3-(trifluoromethyl)phenyl)benzamide 75-78 interferon gamma Homo sapiens 21-30 32199179-9 2020 We concluded that the evaluation of IL-4 and IFN-gamma in HCF-Ag stimulated PBMCs of CE patients should be considered as a useful marker in the follow up of patients with cystic echinococcosis. hcf-ag 58-64 interferon gamma Homo sapiens 45-54 32125282-4 2020 Here, we evaluated the DNA methylation status of TB patients and their asymptomatic household contacts demonstrating that TB patients have DNA hyper-methylation of the IL-2-STAT5, TNF-NF-kappaB and IFN-gamma signaling pathways. Terbium 49-51 interferon gamma Homo sapiens 198-207 31838028-0 2020 The level of natural autoantibodies to IFN-gamma in varicella infections treated with antiviral drug Anaferon for Children: a pilot study. anaferon 101-109 interferon gamma Homo sapiens 39-48 31838028-4 2020 This paper describes our work to analyze the dynamics of NAbs titer to interferon-gamma (IFN-gamma) among healthy children of different age and in patients with varicella infection receiving an antiviral drug Anaferon for children (AC, the API are highly diluted antibodies to IFN-gamma) in comparison with placebo, and to correlate the findings with the treatment results. anaferon 209-217 interferon gamma Homo sapiens 89-98 32289583-11 2020 After adjusting for age, gender, BMI, family income, parental education level, and second-hand smoke exposure, we found that increased PAH exposure was associated with higher AhR and NLRP3 expression and elevated IL-4, IL-10, IL-12p70, IL-18, IL-22, IL-23, TNF-alpha, and IFN-gamma levels. Polycyclic Aromatic Hydrocarbons 135-138 interferon gamma Homo sapiens 272-281 32289583-12 2020 The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression. Polycyclic Aromatic Hydrocarbons 25-28 interferon gamma Homo sapiens 59-68 32172204-6 2020 Melatonin-treated HUVECs showed a decrease of pro-inflammatory mRNAs [interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha)] under the stimulation of SLE medium. Melatonin 0-9 interferon gamma Homo sapiens 100-116 32172204-6 2020 Melatonin-treated HUVECs showed a decrease of pro-inflammatory mRNAs [interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha)] under the stimulation of SLE medium. Melatonin 0-9 interferon gamma Homo sapiens 118-127 32125282-4 2020 Here, we evaluated the DNA methylation status of TB patients and their asymptomatic household contacts demonstrating that TB patients have DNA hyper-methylation of the IL-2-STAT5, TNF-NF-kappaB and IFN-gamma signaling pathways. Terbium 122-124 interferon gamma Homo sapiens 198-207 32221603-8 2020 However, the anti-inflammatory capacity of polyphenols was confirmed by positive associations of IL-4 with phenolic acid (beta = 0.09 P = 0.049) and stilbene (beta = 0.13, P = 0.019) intakes and the negative association of IL-1, IL-2, and IFN-gamma with lignan intake (beta = -0.10, P = 0.034; beta = -0.09, P = 0.049; beta = -0.11, P = 0.023). Polyphenols 43-54 interferon gamma Homo sapiens 239-248 32207168-0 2020 Efficacy of acitretin in the treatment of reactive neutrophilic dermatoses in adult-onset immunodeficiency due to interferon-gamma autoantibody. Acitretin 12-21 interferon gamma Homo sapiens 114-130 30580627-0 2020 Novel betulin derivatives inhibit IFN-gamma and modulates COX-2 expression. betulin 6-13 interferon gamma Homo sapiens 34-43 32438601-8 2020 MoDCs exposed to 2"-FL and CpG-conditioned IEC instructed IFNgamma and IL-10 secretion by CD4+ T-cells, suggesting the development of a regulatory Th1 response. 2'-fucosyllactose 17-22 interferon gamma Homo sapiens 58-66 32489879-0 2020 Interferon-gamma and voriconazole combined therapy for refractory meningeal coccidioidomycosis in a patient with interferon-gamma deficiency. Voriconazole 21-33 interferon gamma Homo sapiens 113-129 32173759-9 2020 However, in GCs resistant very severe GO, IFN-gamma-producing Th17.1 cells were still at a high level, correlating with increased serum triglycerides. Triglycerides 136-149 interferon gamma Homo sapiens 42-51 32549769-4 2020 In this study, miRNA microarray assay revealed that miR-103 was significantly decreased in RAW264.7-derived M1 macrophages upon IFNgamma and LPS stimulation. mir-103 52-59 interferon gamma Homo sapiens 128-136 32508837-7 2020 Cytokine production (IFNgamma) was similarly assessed by incubating 1 mL of whole blood with PMA-ionomycin or IL-2/12 prior to incubation with ECS and subsequent ICS antibodies. PMA ionomycin 93-106 interferon gamma Homo sapiens 21-29 32499867-5 2020 Additionally, entinostat increased both cytotoxicity and IFN-gamma production in human NK cells following coculture with these tumor cells. entinostat 14-24 interferon gamma Homo sapiens 57-66 31995775-7 2020 In the arsenic-exposed group, miR-155-5p, keratin 1(Krt1), keratin 10 (Krt10), and keratin 6c (Krt6c) were significantly increased in the skin (p < 0.05), while NF-AT1, interleukin-2 (IL-2), and interferon-gamma (IFN-gamma) were significantly decreased (p < 0.05). Arsenic 7-14 interferon gamma Homo sapiens 195-211 32499781-7 2020 Cyclosporine A, tacrolimus and steroids dose-dependently inhibited IFN-gamma secretion, and reactivity was further reduced when calcineurin inhibitors were combined with steroids. Cyclosporine 0-14 interferon gamma Homo sapiens 67-76 32499781-7 2020 Cyclosporine A, tacrolimus and steroids dose-dependently inhibited IFN-gamma secretion, and reactivity was further reduced when calcineurin inhibitors were combined with steroids. Tacrolimus 16-26 interferon gamma Homo sapiens 67-76 32499781-7 2020 Cyclosporine A, tacrolimus and steroids dose-dependently inhibited IFN-gamma secretion, and reactivity was further reduced when calcineurin inhibitors were combined with steroids. Steroids 31-39 interferon gamma Homo sapiens 67-76 32499781-7 2020 Cyclosporine A, tacrolimus and steroids dose-dependently inhibited IFN-gamma secretion, and reactivity was further reduced when calcineurin inhibitors were combined with steroids. Steroids 170-178 interferon gamma Homo sapiens 67-76 32385048-6 2020 NK cells were relatively fuel resilient and used Glc, glutamine (Gln), fatty acid, or acetate to power IFN-gamma expression. Glucose 49-52 interferon gamma Homo sapiens 103-112 32385048-6 2020 NK cells were relatively fuel resilient and used Glc, glutamine (Gln), fatty acid, or acetate to power IFN-gamma expression. Glutamine 54-63 interferon gamma Homo sapiens 103-112 32385048-6 2020 NK cells were relatively fuel resilient and used Glc, glutamine (Gln), fatty acid, or acetate to power IFN-gamma expression. Glutamine 65-68 interferon gamma Homo sapiens 103-112 32385048-6 2020 NK cells were relatively fuel resilient and used Glc, glutamine (Gln), fatty acid, or acetate to power IFN-gamma expression. Fatty Acids 71-81 interferon gamma Homo sapiens 103-112 32385048-6 2020 NK cells were relatively fuel resilient and used Glc, glutamine (Gln), fatty acid, or acetate to power IFN-gamma expression. Acetates 86-93 interferon gamma Homo sapiens 103-112 31486697-8 2020 We demonstrated that MHC class II, CD274/B7-H1 and PDCD1LG2/B7-DC were expressed on SFs following treatment with IFNG whereas CD276/B7-H3 was detected on SFs regardless of the presence of IFNG. SFS 84-87 interferon gamma Homo sapiens 113-117 32220217-6 2020 Interferon-gamma (IFN-gamma)-mediated activation of MHC-II gene expression was also inhibited by D-sequence oligonucleotides as well as following infection with either the wild-type AAV or transduction with recombinant AAV vectors. d-sequence oligonucleotides 97-124 interferon gamma Homo sapiens 0-16 32220217-6 2020 Interferon-gamma (IFN-gamma)-mediated activation of MHC-II gene expression was also inhibited by D-sequence oligonucleotides as well as following infection with either the wild-type AAV or transduction with recombinant AAV vectors. d-sequence oligonucleotides 97-124 interferon gamma Homo sapiens 18-27 32953676-7 2020 Conclusion: The combination of cyclophosphamide, prednisolone, and Qing Shen Fang improves conditions of patients with LN and significantly reduces their IFN-gamma and IL-4 levels in serum. Cyclophosphamide 31-47 interferon gamma Homo sapiens 154-163 32953676-7 2020 Conclusion: The combination of cyclophosphamide, prednisolone, and Qing Shen Fang improves conditions of patients with LN and significantly reduces their IFN-gamma and IL-4 levels in serum. Prednisolone 49-61 interferon gamma Homo sapiens 154-163 32145301-2 2020 Neopterin is described as the oxidation product of 7,8-dihydroneopterin, a potent antioxidant generated by monocyte/macrophages in response to interferon-gamma. Neopterin 0-9 interferon gamma Homo sapiens 143-159 32145301-2 2020 Neopterin is described as the oxidation product of 7,8-dihydroneopterin, a potent antioxidant generated by monocyte/macrophages in response to interferon-gamma. 7,8-dihydroneopterin 51-71 interferon gamma Homo sapiens 143-159 32509883-10 2020 Consistent with the local control (skin), systemically (splenocytes), we observed that Treg injection led to lower frequencies of IFNgamma and IL-17A-expressing human T cells, while a trend towards enrichment of FOXP3+ Treg was observed. treg 87-91 interferon gamma Homo sapiens 130-138 32431702-7 2020 Similar cytokine production effects were found with eicosapentaenoic acid (EPA) and arachidonic acid (AA), whereas linoleic acid (LA) increased OX40L surface expression and subsequent T-cell-derived IL-13/IFNgamma ratios, suggesting an increased risk of allergy development. Linoleic Acid 115-128 interferon gamma Homo sapiens 205-213 32154597-9 2020 Although, MAIT and CD8+ CD161hi Valpha7.2- cells displayed a similar cytokine production profile, IFNgamma and TNFalpha production is significantly increased in SAH patients while significant IL-17A production is found in ChA patients. S-Adenosylhomocysteine 161-164 interferon gamma Homo sapiens 98-106 33073254-7 2020 As expected, DEX treatment suppressed multiple LPS-induced pro-inflammatory cytokines (IFN-gamma, IL-6, IL-8, IL-1beta, .TNF-alpha) by >85% and increased the anti-inflammatory cytokine IL-10 by 80%. Dexamethasone 13-16 interferon gamma Homo sapiens 87-96 31160756-3 2020 The persistent polarization of IL4 induced by strong lipid antigens, that is, alpha-galactosylceramide (alphaGC), caused IL4 accumulation at the immunological synapse (IS), which promoted the activation of the IL4R-STAT6 (signal transducer and activator of transcription 6) pathway and production of IL12 in DCs, which enhanced interferon-gamma (IFNgamma) production in iNKT cells. alpha-galactosylceramide 78-102 interferon gamma Homo sapiens 328-344 31160756-3 2020 The persistent polarization of IL4 induced by strong lipid antigens, that is, alpha-galactosylceramide (alphaGC), caused IL4 accumulation at the immunological synapse (IS), which promoted the activation of the IL4R-STAT6 (signal transducer and activator of transcription 6) pathway and production of IL12 in DCs, which enhanced interferon-gamma (IFNgamma) production in iNKT cells. alpha-galactosylceramide 78-102 interferon gamma Homo sapiens 346-354 32237049-9 2020 These data indicated that FLU and EVR suppressed IFN-gamma-induced HLA-DR expression at the transcriptional and post-translational level, respectively, suggesting a potential approach for alleviating DSA-related issues in organ transplantation. Fluvastatin 26-29 interferon gamma Homo sapiens 49-58 32237049-9 2020 These data indicated that FLU and EVR suppressed IFN-gamma-induced HLA-DR expression at the transcriptional and post-translational level, respectively, suggesting a potential approach for alleviating DSA-related issues in organ transplantation. Everolimus 34-37 interferon gamma Homo sapiens 49-58 32237049-9 2020 These data indicated that FLU and EVR suppressed IFN-gamma-induced HLA-DR expression at the transcriptional and post-translational level, respectively, suggesting a potential approach for alleviating DSA-related issues in organ transplantation. dsa 200-203 interferon gamma Homo sapiens 49-58 31995775-7 2020 In the arsenic-exposed group, miR-155-5p, keratin 1(Krt1), keratin 10 (Krt10), and keratin 6c (Krt6c) were significantly increased in the skin (p < 0.05), while NF-AT1, interleukin-2 (IL-2), and interferon-gamma (IFN-gamma) were significantly decreased (p < 0.05). Arsenic 7-14 interferon gamma Homo sapiens 213-222 31995775-9 2020 In immortalized human keratinocytes, silencing and overexpression of NF-AT1 could alter the expression and secretion of immunological dysfunction indicators (IL-2 and IFN-gamma) that are induced by arsenic exposure (p < 0.05); however, miR-155-5p levels did not change significantly (p > 0.05). Arsenic 198-205 interferon gamma Homo sapiens 167-176 32337217-0 2020 Ivacaftor decreases monocyte sensitivity to interferon-gamma in people with cystic fibrosis. ivacaftor 0-9 interferon gamma Homo sapiens 44-60 32501260-2 2020 We assessed associations between diabetes and interferon-gamma (IFN-gamma) TB antigen response among adults with TB infection using US representative data. tb antigen 75-85 interferon gamma Homo sapiens 46-62 32501260-2 2020 We assessed associations between diabetes and interferon-gamma (IFN-gamma) TB antigen response among adults with TB infection using US representative data. tb antigen 75-85 interferon gamma Homo sapiens 64-73 32501260-2 2020 We assessed associations between diabetes and interferon-gamma (IFN-gamma) TB antigen response among adults with TB infection using US representative data. Terbium 75-77 interferon gamma Homo sapiens 46-62 32501260-2 2020 We assessed associations between diabetes and interferon-gamma (IFN-gamma) TB antigen response among adults with TB infection using US representative data. Terbium 75-77 interferon gamma Homo sapiens 64-73 32390844-0 2020 Quercetin Combined With Human Umbilical Cord Mesenchymal Stem Cells Regulated Tumour Necrosis Factor-alpha/Interferon-gamma-Stimulated Peripheral Blood Mononuclear Cells via Activation of Toll-Like Receptor 3 Signalling. Quercetin 0-9 interferon gamma Homo sapiens 107-123 32461349-9 2020 Transcriptomics and proteomics analyses revealed complex effects on the tumor microenvironment triggered by hetIL-15 therapy, including increased levels of IFN-gamma and XCL1 with intratumoral accumulation of XCR1+IRF8+CD103+ conventional type 1 dendritic cells (cDC1). hetil-15 108-116 interferon gamma Homo sapiens 156-165 32461349-10 2020 Concomitantly, the production of the chemokines CXCL9 and CXCL10 by tumor-localized myeloid cells, including cDC1, was boosted by hetIL-15 in an IFN-gamma-dependent manner. hetil-15 130-138 interferon gamma Homo sapiens 145-154 32461350-8 2020 Also in vivo the CpG/saponin-based adjuvant combination plus cryoablation increased the numbers of tumor-specific CD8+ T cells showing enhanced IFNgamma production as compared with single adjuvant treatments. saponin-based adjuvant 21-43 interferon gamma Homo sapiens 144-152 32380309-5 2020 In the in vivo trial, two doses of 2 mg rFIP-fve significantly reduced drops in the CD4/CD8 ratio after PRRSV challenge, and the cytokine mRNA profile of PBMC revealed a tendency of IFN-gamma up-regulation and a decrease in IL-10 in the rFIP-treated group. rfip 40-44 interferon gamma Homo sapiens 182-191 32337217-1 2020 This study demonstrates that initiation of the CFTR modulator ivacaftor in people with cystic fibrosis and susceptible CFTR mutations causes an acute reduction in blood monocyte sensitivity to the key proinflammatory cytokine IFN-gamma http://bit.ly/2TeI6LG. ivacaftor 62-71 interferon gamma Homo sapiens 226-235 32316678-4 2020 As a result, EGCG significantly decreased SEA-induced expression and production of interferon gamma (IFN-gamma). epigallocatechin gallate 13-17 interferon gamma Homo sapiens 83-110 32299501-9 2020 Furthermore, we observed that the ratio of IFN-gamma to IL-10 cytokine levels in the plasma used for MSC priming was significantly correlated with higher suppressive potential and Treg generation induction by primed MSCs, regardless of the clinical status of the donor. treg 180-184 interferon gamma Homo sapiens 43-52 32269142-5 2020 CASE PRESENTATION: We launched a phase I trial incorporating four weekly doses of IFN-gamma in an ACT regimen of high-dose cyclophosphamide (HD Cy), NY-ESO-1-specific T cells, and postinfusion low-dose interleukin (IL)-2. Cyclophosphamide 123-139 interferon gamma Homo sapiens 82-91 32328292-2 2020 We here found that glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive cortisone to the active cortisol and thereby regulates tissue glucocorticoid (GC) levels, was greatly upregulated by IFNgamma and TNFalpha in human umbilical cord-derived MSCs (UC-MSCs) in a synergistic manner. Cortisone 130-139 interferon gamma Homo sapiens 247-255 32328292-2 2020 We here found that glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive cortisone to the active cortisol and thereby regulates tissue glucocorticoid (GC) levels, was greatly upregulated by IFNgamma and TNFalpha in human umbilical cord-derived MSCs (UC-MSCs) in a synergistic manner. Hydrocortisone 154-162 interferon gamma Homo sapiens 247-255 32172522-9 2020 A noticeable reduction was recorded in inflammatory biomarkers (cytokines) in the vitamin D-treated group (IL-6 p = 0.08, TNF-alpha p = 0.02, IL-2 p = 0.36) with notable elevation in IFN-gamma (p = 0.65) compared to the control group. Vitamin D 82-91 interferon gamma Homo sapiens 183-192 32078941-6 2020 Sunitinib malate increased infiltration of CD8+ T cells and decreased regulatory T cells (Tregs), accompanied by inhibited expression of TGF-beta1 and IL-10 and increased CCL-28, IFN-gamma and IL-12, but no significant inhibition of myeloid-derived suppressor cells (MDSCs) was observed. Sunitinib 0-16 interferon gamma Homo sapiens 179-188 32306920-11 2020 The correlation of GRP78-positive clones with increased levels of IFNgamma supports the idea that GRP78 expression in PBMCs might serve as a new predictive marker to identify the possible benefits of taxanes in the neoadjuvant setting. Taxoids 200-207 interferon gamma Homo sapiens 66-74 32275689-8 2020 We found that both types of EV from IFN-gamma treated D3H2LN cells and non-treated D3H2LN cells contained adenosine, which has immunosuppressive effects. Adenosine 106-115 interferon gamma Homo sapiens 36-45 32368288-6 2020 Specifically, CG-745 induces or extends IL-2 and IFN-gamma expression with or without additional stimulation, and increases proliferation of cytotoxic T cells and NK cells, while inhibiting proliferation of regulatory T cells. UNII-QA3Y8EZG57 14-20 interferon gamma Homo sapiens 49-58 31605536-2 2020 Interferon-gamma signaling mediated by Janus kinase (JAK) has been implicated in the pathogenesis of vitiligo.1 Systemic administration of tofacitinib, a potent JAK1/3 inhibitor, has been effective in treating vitiligo in case reports,2 however, it is associated with infections, malignancies, cytopenias, gastrointestinal perforations, and hyperlipidemia in some patients with rheumatoid arthritis. tofacitinib 139-150 interferon gamma Homo sapiens 0-16 31795627-2 2020 Co-stimulation of T cell activation via TLR9 induces production of interferon gamma (IFN-gamma), priming of which is critical for differentiation of pro-inflammatory macrophages. 12-(4'-azido-2'-nitrophenoxy)dodecanoyl-coenzyme A 0-2 interferon gamma Homo sapiens 67-94 32018066-6 2020 Consequently, andrographolide and anti-PD-1 antibody co-treatment boosted the function of CD4+ and CD8+ T cells evidenced by considerable tissue infiltration, elevated IFN-gamma secretion and enhanced expression of cytotoxic T-cell related molecules including FasL, perforin and Granzyme B, which significantly decreases the tumor load. andrographolide 14-29 interferon gamma Homo sapiens 168-177 32269142-5 2020 CASE PRESENTATION: We launched a phase I trial incorporating four weekly doses of IFN-gamma in an ACT regimen of high-dose cyclophosphamide (HD Cy), NY-ESO-1-specific T cells, and postinfusion low-dose interleukin (IL)-2. Cysteine 144-146 interferon gamma Homo sapiens 82-91 32269142-9 2020 CONCLUSION: We describe a new and serious toxicity of immunotherapy from IFN-gamma combined with HD Cy-based lymphodepletion and low-dose IL-2. Cysteine 100-102 interferon gamma Homo sapiens 73-82 32317293-10 2020 ALKS 4230 treatment induced significantly lower levels of proinflammatory cytokines, including tumor necrosis factor alpha, interleukin-6, and interferon gamma relative to rhIL-2. alks 4230 0-9 interferon gamma Homo sapiens 143-159 32004536-5 2020 In addition, measurements of blood cytokine levels after repeat injection indicate that reduced levels of inflammatory cytokines (IL-6, IFN-gamma,TNFalpha) are elicited in response to lipoplexes coated with lactose as compared to PEG. Lactose 207-214 interferon gamma Homo sapiens 136-145 32067413-8 2020 In addition, we found that ODNs with six or more consecutive guanosines (ODNs with poly-G sequences) may competitively inhibit the IFN-gamma receptor and abolish the effect of IFN-gamma, thereby suppressing apoptosis and indoleamine 2,3-dioxygenase 1 expression in human lung cancer cells. Guanosine 61-71 interferon gamma Homo sapiens 131-140 31782556-5 2020 The dextran sulfate plasma adsorption system reduced IFN-gamma, IL-8, IL-1ra, eotaxin, TNF, MCP-1, PDGF-BB, MIP-1beta, and IP-10 (P < .05). Sulfates 12-19 interferon gamma Homo sapiens 53-62 32122997-4 2020 Peptide scan analyses led to the discovery of a peptide containing methyl lysines recognized by a mAb that binds to native HBHA ~100-fold better than to rHBHA-Ms This peptide was also recognized by T cells from latently infected humans, as evidenced by IFN-gamma release upon peptide stimulation. Lysine 74-81 interferon gamma Homo sapiens 253-262 32067413-8 2020 In addition, we found that ODNs with six or more consecutive guanosines (ODNs with poly-G sequences) may competitively inhibit the IFN-gamma receptor and abolish the effect of IFN-gamma, thereby suppressing apoptosis and indoleamine 2,3-dioxygenase 1 expression in human lung cancer cells. Guanosine 61-71 interferon gamma Homo sapiens 176-185 32067413-8 2020 In addition, we found that ODNs with six or more consecutive guanosines (ODNs with poly-G sequences) may competitively inhibit the IFN-gamma receptor and abolish the effect of IFN-gamma, thereby suppressing apoptosis and indoleamine 2,3-dioxygenase 1 expression in human lung cancer cells. Poly G 83-89 interferon gamma Homo sapiens 131-140 32233673-4 2021 Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 microM significantly reduced the production of interleukins (IL-1beta, IL-2 and IL-6), interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha). Flavonoids 56-66 interferon gamma Homo sapiens 180-196 32067413-8 2020 In addition, we found that ODNs with six or more consecutive guanosines (ODNs with poly-G sequences) may competitively inhibit the IFN-gamma receptor and abolish the effect of IFN-gamma, thereby suppressing apoptosis and indoleamine 2,3-dioxygenase 1 expression in human lung cancer cells. Poly G 83-89 interferon gamma Homo sapiens 176-185 32067413-11 2020 CONCLUSIONS: This study suggests that ODNs containing six or more consecutive guanosines may inhibit the binding of IFN-gamma to IFN-gamma receptor. Guanosine 78-88 interferon gamma Homo sapiens 116-125 32067413-13 2020 KEY POINTS: Significant findings of the study: Oligodeoxynucleotides with a contiguous sequence of six or more guanosines may competitively inhibit the IFN-gamma receptor and abolish the action of IFN-gamma. Guanosine 111-121 interferon gamma Homo sapiens 152-161 32067413-13 2020 KEY POINTS: Significant findings of the study: Oligodeoxynucleotides with a contiguous sequence of six or more guanosines may competitively inhibit the IFN-gamma receptor and abolish the action of IFN-gamma. Guanosine 111-121 interferon gamma Homo sapiens 197-206 32489023-14 2020 Compared with the model control group, the high and low doses of Compound Qinlan Oral Liquid significantly reduced lung tissue viral load(P<0.01), increased cross blood CD4~+ T lymphocytes, CD8~+ T lymphocytes and total B lymphocyte percentage(P<0.01), reduced serum motilin content(P<0.01), reduced IL-6, IL-10, TNF-alpha and IFN-gamma levels in lungs(P<0.01) and reduced lung tissue inflammation. qinlan 74-80 interferon gamma Homo sapiens 327-336 32233673-4 2021 Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 microM significantly reduced the production of interleukins (IL-1beta, IL-2 and IL-6), interferon-gamma (IFN-gamma), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha). Flavonoids 56-66 interferon gamma Homo sapiens 198-207 32214351-5 2020 The results showed that PCC0208025 inhibited the PD-1/PD-L1 proteins binding, and rescued PD-L1-mediated inhibition of IFN-gamma production in human CD3+ T cells in vitro. pcc0208025 24-34 interferon gamma Homo sapiens 119-128 31964747-3 2020 IFNgamma activates human cells to produce the tryptophan (trp) catabolizing enzyme, IDO. Tryptophan 46-56 interferon gamma Homo sapiens 0-8 31964747-3 2020 IFNgamma activates human cells to produce the tryptophan (trp) catabolizing enzyme, IDO. Tryptophan 58-61 interferon gamma Homo sapiens 0-8 31964747-4 2020 Consequently, there is a reduction in cytosolic trp in IFNgamma-activated host cells. Tryptophan 48-51 interferon gamma Homo sapiens 55-63 31964747-8 2020 Chlamydial persistence is characterized by a halt in the division cycle, aberrant morphology, and, in the case of IFNgamma-induced persistence, trp codon-dependent changes in transcription. Tryptophan 144-147 interferon gamma Homo sapiens 114-122 32188404-1 2020 BACKGROUND: The most common infection in patients positive for anti-interferon-gamma autoantibodies (anti-IFN-gamma AAbs) is disseminated nontuberculous mycobacterial (dNTM) infection. p-Aminoazobenzene 116-120 interferon gamma Homo sapiens 68-84 32337262-8 2020 In addition, by GSEA, expression of CXCL1, CXCL11, CXCL2, and CXCL3 was correlated with several signaling pathways, including NOD-like receptor, oxidative phosphorylation, mTORC1, interferon-gamma response, and IL6/JAK/STAT3 pathways. gsea 16-20 interferon gamma Homo sapiens 180-196 32256470-7 2020 Kynurenine elevation was positively correlated with serum IFN-gamma levels in acute infection, whereas, it was negatively correlated with parasite load and P. vivax LDH levels. Kynurenine 0-10 interferon gamma Homo sapiens 58-67 32201152-5 2021 Ruxolitinib decreases the activity of type I T-helper cells, leading to decreased release of cytokines including tumor necrosis factor-alpha, interleukin-1 (IL-1), IL-6, interferon-gamma, and production of IL-12, which can be a risk factor for opportunistic infections. ruxolitinib 0-11 interferon gamma Homo sapiens 170-186 32188404-1 2020 BACKGROUND: The most common infection in patients positive for anti-interferon-gamma autoantibodies (anti-IFN-gamma AAbs) is disseminated nontuberculous mycobacterial (dNTM) infection. p-Aminoazobenzene 116-120 interferon gamma Homo sapiens 106-115 32188404-1 2020 BACKGROUND: The most common infection in patients positive for anti-interferon-gamma autoantibodies (anti-IFN-gamma AAbs) is disseminated nontuberculous mycobacterial (dNTM) infection. dntm 168-172 interferon gamma Homo sapiens 68-84 32188404-1 2020 BACKGROUND: The most common infection in patients positive for anti-interferon-gamma autoantibodies (anti-IFN-gamma AAbs) is disseminated nontuberculous mycobacterial (dNTM) infection. dntm 168-172 interferon gamma Homo sapiens 106-115 32188404-2 2020 Here, we report a rare case of triple infection caused by Cryptococcus, varicella-zoster virus (VZV), and nontuberculous mycobacterium in a patient with anti-IFN-gamma AAbs. p-Aminoazobenzene 168-172 interferon gamma Homo sapiens 158-167 31549414-5 2020 METHODS: Seventeen abacavir analogues were synthesized and cytokine secretion from abacavir/abacavir analogue-responsive CD8+ T-cell clones was measured using IFN-gamma ELIspot. abacavir 83-91 interferon gamma Homo sapiens 159-168 32165709-6 2020 The independent risk factors associated with BMP were age >5years (OR 2.06; 95% CI 1.43 to 2.98), higher IL-10 level (>10 ng/L, 2.19; 95% CI 1.46 to 3.28), higher IFN-gamma level (>30 ng/L, 1.69; 95% CI 1.13 to 2.54), and presence of complication (3.43; 95% CI 1.45 to 8.09). 2-tert-butyl-4-methylphenol 45-48 interferon gamma Homo sapiens 163-172 31634391-6 2020 The effect of ATRA on IFN-gamma-mediated inhibition of DRA function, expression, and promoter activity were elucidated. Tretinoin 14-18 interferon gamma Homo sapiens 22-31 31634391-8 2020 RESULTS: All-trans retinoic acid (10 muM, 24 h) abrogated IFN-gamma (30 ng/mL, 24 h)-induced decrease in DRA function, expression, and promoter activity in Caco-2 cells. Tretinoin 9-32 interferon gamma Homo sapiens 58-67 31634391-9 2020 All-trans retinoic acid altered IFN-gamma signaling via blocking IFN-gamma-induced tyrosine phosphorylation of STAT-1. Tretinoin 0-23 interferon gamma Homo sapiens 32-41 31634391-9 2020 All-trans retinoic acid altered IFN-gamma signaling via blocking IFN-gamma-induced tyrosine phosphorylation of STAT-1. Tretinoin 0-23 interferon gamma Homo sapiens 65-74 31634391-9 2020 All-trans retinoic acid altered IFN-gamma signaling via blocking IFN-gamma-induced tyrosine phosphorylation of STAT-1. Tyrosine 83-91 interferon gamma Homo sapiens 32-41 31634391-9 2020 All-trans retinoic acid altered IFN-gamma signaling via blocking IFN-gamma-induced tyrosine phosphorylation of STAT-1. Tyrosine 83-91 interferon gamma Homo sapiens 65-74 32265897-4 2020 By ICP co-expression analysis, we also identified three IFNgamma-induced genes [(IFNgamma-inducible lysosomal thiol reductase (IFI30), guanylate binding protein1 (GBP1), and guanylate binding protein 4 (GBP4)] as potential novel ICPRGs. Sulfhydryl Compounds 110-115 interferon gamma Homo sapiens 56-64 31549414-8 2020 RESULTS: Abacavir and ten analogues stimulated CD8+ T-cell IFN-gamma release. abacavir 9-17 interferon gamma Homo sapiens 59-68 31549414-5 2020 METHODS: Seventeen abacavir analogues were synthesized and cytokine secretion from abacavir/abacavir analogue-responsive CD8+ T-cell clones was measured using IFN-gamma ELIspot. abacavir 83-91 interferon gamma Homo sapiens 159-168 31794784-12 2020 This paper summarizes research progress on the IFN-gamma signalling pathway, heparin interference with IFN-gamma activity and the structure-activity relationship between heparin and IFN-gamma. Heparin 77-84 interferon gamma Homo sapiens 103-112 31794784-0 2020 The role of heparin/heparan sulphate in the IFN-gamma-led Arena. Heparin 12-19 interferon gamma Homo sapiens 44-53 31794784-12 2020 This paper summarizes research progress on the IFN-gamma signalling pathway, heparin interference with IFN-gamma activity and the structure-activity relationship between heparin and IFN-gamma. Heparin 77-84 interferon gamma Homo sapiens 103-112 31794784-0 2020 The role of heparin/heparan sulphate in the IFN-gamma-led Arena. Heparitin Sulfate 20-36 interferon gamma Homo sapiens 44-53 31327083-8 2020 DOXY group exhibited a significant increase in the levels of anti-inflammatory interleukin (IL)-10 and a reduction in IL-8, IFN-y, IL-6, and IL-17 (p < 0.05), significant reduction in periodontal pathogens (p < 0.05), and a lower mean percentage of HbA1C at 3 months (p < 0.05). Doxycycline 0-4 interferon gamma Homo sapiens 124-129 31794784-4 2020 Electrostatic interactions can be generated between the highly sulphated HS region and specific basic amino acid residues in the IFN-gamma structure, thereby detaining IFN-gamma on the cell surface, and the concentration of IFN-gamma on the cell surface is thus, changed. hs region 73-82 interferon gamma Homo sapiens 129-138 31794784-4 2020 Electrostatic interactions can be generated between the highly sulphated HS region and specific basic amino acid residues in the IFN-gamma structure, thereby detaining IFN-gamma on the cell surface, and the concentration of IFN-gamma on the cell surface is thus, changed. hs region 73-82 interferon gamma Homo sapiens 168-177 31794784-4 2020 Electrostatic interactions can be generated between the highly sulphated HS region and specific basic amino acid residues in the IFN-gamma structure, thereby detaining IFN-gamma on the cell surface, and the concentration of IFN-gamma on the cell surface is thus, changed. hs region 73-82 interferon gamma Homo sapiens 168-177 31794784-4 2020 Electrostatic interactions can be generated between the highly sulphated HS region and specific basic amino acid residues in the IFN-gamma structure, thereby detaining IFN-gamma on the cell surface, and the concentration of IFN-gamma on the cell surface is thus, changed. Amino Acids, Basic 96-112 interferon gamma Homo sapiens 129-138 31794784-4 2020 Electrostatic interactions can be generated between the highly sulphated HS region and specific basic amino acid residues in the IFN-gamma structure, thereby detaining IFN-gamma on the cell surface, and the concentration of IFN-gamma on the cell surface is thus, changed. Amino Acids, Basic 96-112 interferon gamma Homo sapiens 168-177 31794784-4 2020 Electrostatic interactions can be generated between the highly sulphated HS region and specific basic amino acid residues in the IFN-gamma structure, thereby detaining IFN-gamma on the cell surface, and the concentration of IFN-gamma on the cell surface is thus, changed. Amino Acids, Basic 96-112 interferon gamma Homo sapiens 168-177 31794784-7 2020 The structural similarity provides a basis for modelling exogenous heparin dependence for interference with IFN-gamma function. Heparin 67-74 interferon gamma Homo sapiens 108-117 31794784-9 2020 Second, the principle of priority occupancy; heparin can occupy the receptor binding site on cytokines, partially preventing the IFN-gamma-IFN-gammaR interaction. Heparin 45-52 interferon gamma Homo sapiens 129-138 31794784-11 2020 To decipher the mechanism by which heparin influences IFN-gamma activity, studies of the structure-activity relationship are in progress. Heparin 35-42 interferon gamma Homo sapiens 54-63 31786502-2 2020 Previous studies have revealed the ability of interferon gamma (IFN-gamma) to activate and promote a synthetic phenotype in AoSMCs that parallels marked up-regulation of truncated tryptophanyl-tRNA synthetase (mini-TrpRS). tryptophyl-arginyl-tryptophyl-tryptophyl-tryptophyl-tryptophanamide 215-220 interferon gamma Homo sapiens 46-73 31786502-3 2020 Here we provide evidence to support an essential dependency of IFN-gamma-induced activation and synthetic phenotype in AoSMC on mini-TrpRS. tryptophyl-arginyl-tryptophyl-tryptophyl-tryptophyl-tryptophanamide 133-138 interferon gamma Homo sapiens 63-72 31797350-1 2020 Neopterin is primarily synthesized and released by activated macrophages/monocytes upon stimulation with interferon-gamma and is considered as a marker for macrophage activation. Neopterin 0-9 interferon gamma Homo sapiens 105-121 30047620-6 2020 Before DPCP treatment, higher serum IFN-gamma and IL-12 cytokine levels were observed in AA patients compared to healthy controls. diphenylcyclopropenone 7-11 interferon gamma Homo sapiens 36-45 30047620-9 2020 Post-treatment DPCP responders exhibited significantly decreased IFN-gamma and IL-12, and increased IL-4 and IL-10. diphenylcyclopropenone 15-19 interferon gamma Homo sapiens 65-74 31876322-6 2020 Degranulating CD8 T cells in general and both-degranulating and IFNgamma producing CD8 T cells in particular dominated abacavir-specific immune response. abacavir 119-127 interferon gamma Homo sapiens 64-72 32383705-15 2020 As it was established the amount of bacteria producing short-chain fatty acids (SCFA) markedly decrease in T2-D, and treatment with SCFA reduced induction of TFN-alpha, IL-10 and IL-17 cytokines in contrast to IL-6, IFN-y and IL-22, without modification of their induction after using of SCFA. Fatty Acids, Volatile 132-136 interferon gamma Homo sapiens 216-221 32383705-15 2020 As it was established the amount of bacteria producing short-chain fatty acids (SCFA) markedly decrease in T2-D, and treatment with SCFA reduced induction of TFN-alpha, IL-10 and IL-17 cytokines in contrast to IL-6, IFN-y and IL-22, without modification of their induction after using of SCFA. Fatty Acids, Volatile 132-136 interferon gamma Homo sapiens 216-221 32114280-0 2020 Curcumin mediates attenuation of pro-inflammatory interferon gamma and interleukin 17 cytokine responses in psoriatic disease, strengthening its role as a dietary immunosuppressant. Curcumin 0-8 interferon gamma Homo sapiens 50-66 32114280-3 2020 We hypothesized that curcumin could inhibit interferon (IFN)-gamma and interleukin (IL)-17 production in peripheral blood mononuclear cells from patients with psoriasis and psoriatic arthritis (PsA). Curcumin 21-29 interferon gamma Homo sapiens 44-66 32114280-4 2020 To this end, we assessed the in vitro effect of curcumin on IFN-gamma production by cluster differentiation (CD)4(+), CD8(+) T cells, natural killer (NK) and NKT cells and on IL-17 production by CD4(+) T cells from 34 patients with psoriatic disease (22 with psoriasis and 12 with PsA); 15 normal subjects were included as healthy controls. Curcumin 48-56 interferon gamma Homo sapiens 60-69 32114280-6 2020 Curcumin significantly decreased, in a dose dependent manner, IFNgamma-production by CD4(+) and CD8(+) T cells, and NK and NKT cells in patients with psoriatic disease and healthy controls. Curcumin 0-8 interferon gamma Homo sapiens 62-70 32114280-9 2020 In conclusion, curcumin in vitro inhibits pro-inflammatory IFN-gamma and IL-17 production in psoriatic disease, and this may strengthen its role as a dietary immunosuppressant in patients with this disease. Curcumin 15-23 interferon gamma Homo sapiens 59-68 32062328-9 2020 Moreover, wogonoside reduced the levels of the proinflammatory cytokines IL-13 and IFN-gamma to maintain intestinal immune homeostasis. wogonoside 10-20 interferon gamma Homo sapiens 83-92 32122595-9 2020 Cytokine and ISG expression levels in liver and spleen samples were detected and IFN-gamma and Mx1 genes were dominantly up-regulated following PiIFN-alpha treatment (p < 0.05). piifn-alpha 144-155 interferon gamma Homo sapiens 81-90 32094501-5 2020 Despite decreased frequency of the total memory CD8 T-cell compartment, the proportion of innate-memory CD8 T-cells and their IFNgamma expression in response to an innate-like stimulation increased in response to dasatinib. Dasatinib 213-222 interferon gamma Homo sapiens 126-134 32290940-29 2020 The urine 1-OHPyr content of coke oven workers was negatively correlated with TH1/TH2 ratio and IFN-gamma expression level, and positively correlated with IL-4 and IL-10 levels. 1-ohpyr 10-17 interferon gamma Homo sapiens 96-105 32005538-6 2020 BCG-IND demonstrated significantly decreased membrane integrity, lower RNA content, and weaker IFN-gamma inducing activity in whole blood compared to other BCGs. bcg-ind 0-7 interferon gamma Homo sapiens 95-104 31882299-2 2020 Herein, in order to simplify the structure of two kinds of IDO1 inhibitors from marine alkaloid, Exiguamine A and Tsitsikammamines, we designed, synthesized a series of 1H-indole-4,7-dione derivatives and evaluated their inhibitory activity in IDO1 enzyme and in IFN-gamma stimulated Hela cells in vitro. tsitsikammamine A 114-130 interferon gamma Homo sapiens 263-272 32098277-5 2020 Kaempferol suppressed interferon-gamma dependent immunometabolic pathways: Formation of the oxidative stress biomarker neopterin and catabolism of tryptophan were inhibited dose-dependently in stimulated cells. kaempferol 0-10 interferon gamma Homo sapiens 22-38 32098277-5 2020 Kaempferol suppressed interferon-gamma dependent immunometabolic pathways: Formation of the oxidative stress biomarker neopterin and catabolism of tryptophan were inhibited dose-dependently in stimulated cells. Neopterin 119-128 interferon gamma Homo sapiens 22-38 32098277-5 2020 Kaempferol suppressed interferon-gamma dependent immunometabolic pathways: Formation of the oxidative stress biomarker neopterin and catabolism of tryptophan were inhibited dose-dependently in stimulated cells. Tryptophan 147-157 interferon gamma Homo sapiens 22-38 32153576-3 2020 In the course of anti-tumor immune response, the pro-inflammatory cytokine interferon gamma (IFN-gamma) induces both, the enzyme indoleamine 2,3-dioxygenase (IDO) to degrade tryptophan and the enzyme GTP-cyclohydrolase I to form neopterin. Tryptophan 174-184 interferon gamma Homo sapiens 75-102 32153576-3 2020 In the course of anti-tumor immune response, the pro-inflammatory cytokine interferon gamma (IFN-gamma) induces both, the enzyme indoleamine 2,3-dioxygenase (IDO) to degrade tryptophan and the enzyme GTP-cyclohydrolase I to form neopterin. Neopterin 229-238 interferon gamma Homo sapiens 75-102 32190686-3 2020 Results: Compared to healthy people, SAA patients had higher levels of tumor necrosis factor alpha (TNF-alpha (TNF-gamma (IFN-gamma (IFN-beta (MIP-1beta (MIP-1alpha (TNF-alpha (TNF-beta (MIP-1beta (MIP-1beta (MIP-1gamma (IFN-alpha (TNF. saa 37-40 interferon gamma Homo sapiens 122-131 31840993-3 2020 The utility of one-pot DSL-deselenization chemistry at phenylalanine and leucine was demonstrated through the rapid synthesis of a glycosylated interferon-gamma fragment and the chemokine-binding protein UL22A, respectively. leucyl-phenylalanine 55-68 interferon gamma Homo sapiens 144-160 32132994-3 2020 We show here that macrophage activation with IFNgamma results in increased aerobic glycolysis, iNOS-dependent inhibition of respiration, and accumulation of triacylglycerol. Triglycerides 157-172 interferon gamma Homo sapiens 45-53 32117235-7 2020 Our results show a heterogeneous and inversely correlated expression profile of TRP-metabolizing genes among GBM and HNSCC cells, with low, but inducible IDO1 expression upon IFNgamma treatment. Tryptophan 80-83 interferon gamma Homo sapiens 175-183 32029842-4 2020 Now, in cultured tubular cells, we demonstrated that a crosslinked self-assembled star-shaped polyglutamate (PGA) conjugate of bisdemethoxycurcumin (St-PGA-CL-BDMC) inhibits apoptosis and necroptosis induced by Tweak/TNFalpha/IFNgamma alone or concomitant to caspase inhibition. Polyglutamic Acid 94-107 interferon gamma Homo sapiens 226-234 32029842-4 2020 Now, in cultured tubular cells, we demonstrated that a crosslinked self-assembled star-shaped polyglutamate (PGA) conjugate of bisdemethoxycurcumin (St-PGA-CL-BDMC) inhibits apoptosis and necroptosis induced by Tweak/TNFalpha/IFNgamma alone or concomitant to caspase inhibition. Polyglutamic Acid 109-112 interferon gamma Homo sapiens 226-234 32029842-4 2020 Now, in cultured tubular cells, we demonstrated that a crosslinked self-assembled star-shaped polyglutamate (PGA) conjugate of bisdemethoxycurcumin (St-PGA-CL-BDMC) inhibits apoptosis and necroptosis induced by Tweak/TNFalpha/IFNgamma alone or concomitant to caspase inhibition. bisdemethoxycurcumin 127-147 interferon gamma Homo sapiens 226-234 32029842-4 2020 Now, in cultured tubular cells, we demonstrated that a crosslinked self-assembled star-shaped polyglutamate (PGA) conjugate of bisdemethoxycurcumin (St-PGA-CL-BDMC) inhibits apoptosis and necroptosis induced by Tweak/TNFalpha/IFNgamma alone or concomitant to caspase inhibition. st-pga-cl-bdmc 149-163 interferon gamma Homo sapiens 226-234 32076052-5 2020 In vitro, cefazolin decreased proliferation of PBMC (peripheral blood mononuclear cells) following IL-2, IL-4 and IL-15 stimulation, reduced production of IFN-gamma, IL-17 and TNF-alpha in IL-2- and IL-15-treated PBMC and in IL-15 stimulated natural killer (NK) cells, attenuated IL-4-dependent expression of CD11c in monocyte-derived dendritic cells and suppressed phosphorylation of JAK3 in response to IL-2 and IL-15 in PBMC, to IL-4 in TF-1 (erythroleukemic cell line) and to IL-21 in NK-92 (NK cell line). Cefazolin 10-19 interferon gamma Homo sapiens 155-164 31751457-8 2020 RESULTS: Pretreatment with tofacitinib prevented IFN-gamma-induced decreases in transepithelial electrical resistance (TER) and increases in 4 kDa FITC-dextran permeability (FD4), partly due to claudin-2 transcriptional regulation and restriction of ZO-1 rearrangement at tight junctions. tofacitinib 27-38 interferon gamma Homo sapiens 49-58 31751457-9 2020 Although tofacitinib administered after IFN-gamma challenge only partially normalized TER and claudin-2 levels, FD4 permeability and ZO-1 localization were fully recovered. tofacitinib 9-20 interferon gamma Homo sapiens 40-49 31751457-10 2020 The IFN-gamma-induced FD4 permeability in primary human colonoids was fully rescued by tofacitinib. tofacitinib 87-98 interferon gamma Homo sapiens 4-13 31840993-3 2020 The utility of one-pot DSL-deselenization chemistry at phenylalanine and leucine was demonstrated through the rapid synthesis of a glycosylated interferon-gamma fragment and the chemokine-binding protein UL22A, respectively. leucylleucine 73-80 interferon gamma Homo sapiens 144-160 32010486-6 2020 Upon adding sMICA, the release of cytokines IFN-gamma, TNF-alpha, and IL-8 by NK cell line (NKL) under stimulation of immobilized rMICA was blocked. MHC class I-related chain A 130-135 interferon gamma Homo sapiens 44-53 31723000-5 2020 Elimination of Tregs with CD25 blockade before anti-VEGF treatment restored IFNgamma production from CD8+ T cells and improved antitumor response from anti-VEGF therapy. tregs 15-20 interferon gamma Homo sapiens 76-84 32250253-6 2020 RESULTS: PL induced T lymphocyte proliferation and CD69 expression, and promoted a transient upregulation of IFN-gamma and TNF-alpha. pl 9-11 interferon gamma Homo sapiens 109-118 31608441-7 2020 We found that T1-IFNs were able to boost interferon-gamma and granzyme B production in 5-amino-6-d-ribitylaminouracil/methylglyoxal-stimulated MAIT cells. 5-amino-6-D-ribitylaminouracil 87-117 interferon gamma Homo sapiens 41-57 31608441-7 2020 We found that T1-IFNs were able to boost interferon-gamma and granzyme B production in 5-amino-6-d-ribitylaminouracil/methylglyoxal-stimulated MAIT cells. Pyruvaldehyde 118-131 interferon gamma Homo sapiens 41-57 31991764-2 2020 We previously synthesized alpha and beta anomers of DHE-glycosides and compared their inhibitory activity on CCL17 and CCL22 mRNA expression induced by TNF-alpha/IFN-gamma in activated HaCaTs. 3,17-dihydroxy-5-estrene 52-66 interferon gamma Homo sapiens 162-171 31770617-3 2020 QuantiFERON-TB Gold in-tube (QFT-GIT) assay was used to measure IFN-gamma response to M. tuberculosis antigens at baseline (T0) and at 6 (T1) and 33 (T2) months after completion of therapy. -tb gold 11-19 interferon gamma Homo sapiens 64-73 31651714-6 2020 In this study, we demonstrate that mangiferin interferes with inflammation, lipid and calcium signaling which selectively inhibits multiple NFkB target genes including interleukin-6, tumor necrosis factor, interferon gamma, vascular endothelial growth factor receptor 2, plasminogen activator urokinase, matrix metalloprotease 19, C-C Motif Chemokine Ligand 2 and placental growth factor. mangiferin 35-45 interferon gamma Homo sapiens 206-302 31991717-2 2020 In an in vitro model of macrophage activation, induced by lipopolysaccharide + interferon-gamma (LPS + IFN-gamma), we here report the ability of carnosine to modulate pro-oxidant and pro-inflammatory activities of macrophages, representing the primary cell type that is activated as a part of the immune response. Carnosine 145-154 interferon gamma Homo sapiens 103-112 31876196-12 2020 When co-cultured with BPA-treated moDCs, cytokines (IFN-gamma, IL4, IL17, IL10) and transcription factors (T-bet, Gata3, RoR-gammat, Foxp3) of CD4+ T cells showed imbalance of Th1/Th2/Th17/Treg polarization, with Th1 and Th17 dominating.Conclusions: BPA altered the function of moDCs through ERalpha, including antigen capture, secretion of inflammatory factors, and ability to stimulate T cells, as well as accelerated the progression and further deterioration of pSS. bisphenol A 22-25 interferon gamma Homo sapiens 52-61 31853913-10 2020 7,3",4"-Trihydroxyisoflavone also reduced TNF-alpha/IFN-gamma-induced phosphorylation of ERK1/2 and JNK1/2. 3',4',7-trihydroxyisoflavone 0-28 interferon gamma Homo sapiens 52-61 31621209-2 2020 In human studies, PTX has been shown to decrease T-cell production of cytokines such as IL-2 and IFN-gamma. Pentoxifylline 18-21 interferon gamma Homo sapiens 97-106 31991764-3 2020 Recently, we synthesized a new type of DHE-glycosides, 3-epi-5,6-dihydroergosterol(3-epi-DHE)-glycosides, and compared its inhibitory activity on mRNA expression levels of CCL17 and CCL22 in TNF-alpha/IFN-gamma-induced HaCaT. 3,17-dihydroxy-5-estrene 39-53 interferon gamma Homo sapiens 201-210 31991764-3 2020 Recently, we synthesized a new type of DHE-glycosides, 3-epi-5,6-dihydroergosterol(3-epi-DHE)-glycosides, and compared its inhibitory activity on mRNA expression levels of CCL17 and CCL22 in TNF-alpha/IFN-gamma-induced HaCaT. valiolol 55-104 interferon gamma Homo sapiens 201-210 31991764-4 2020 DHE-Xly did not affect TNF-alpha/IFN-gamma induced CCL17 and CCL22 mRNA expression in HaCaTs, however, 3-epi-DHE-Xly strongly inhibited TNF-alpha/IFN-gamma induced CCL17 and CCL22 mRNA expression levels in human keratinocytes. 3,17-dihydroxy-5-estrene 103-112 interferon gamma Homo sapiens 146-155 31672285-3 2020 Here, we demonstrated that combretastatin A-4 phosphate (CA4P), a vascular disrupting agent (VDA), can significantly improve the infiltration ability of CAR-T cells in solid tumors as evidenced by elevated levels of IFN-gamma. fosbretabulin 27-55 interferon gamma Homo sapiens 216-225 31756447-6 2020 Additionally, an increased HUVEC-specific antibody level, activated CTLs and an elevated IFN-gamma level in cultured splenocytes were revealed after treatment with HUVEC vaccine with 5 mg/kg DOC. docetaxel 191-194 interferon gamma Homo sapiens 89-98 31676069-2 2020 We previously demonstrated that PMFs such as nobiletin potentiate the cytolytic activity of the human leukemic natural killer cell line KHYG-1 and increased level of the cytotoxic protein granzyme B (GrB) and the cytokine interferon-gamma (IFN-gamma). flavone 32-36 interferon gamma Homo sapiens 240-249 31676069-2 2020 We previously demonstrated that PMFs such as nobiletin potentiate the cytolytic activity of the human leukemic natural killer cell line KHYG-1 and increased level of the cytotoxic protein granzyme B (GrB) and the cytokine interferon-gamma (IFN-gamma). nobiletin 45-54 interferon gamma Homo sapiens 240-249 31974378-3 2020 Among those lipids, cholesterol is required for the optimal IFN-gamma production from iNKT cells. Cholesterol 20-31 interferon gamma Homo sapiens 60-69 31974378-4 2020 Lactic acid in tumor microenvironment reduces expression of PPARgamma in intratumoral iNKT cells and consequently diminishes their cholesterol synthesis and IFN-gamma production. Lactic Acid 0-11 interferon gamma Homo sapiens 157-166 31974378-5 2020 Importantly, PPARgamma agonist pioglitazone, a thiazolidinedione drug for type 2 diabetes, successfully restores IFN-gamma production in tumor-infiltrating iNKT cells from both human patients and mouse models. pioglitazone 31-43 interferon gamma Homo sapiens 113-122 31952519-11 2020 Poly(I:C)-mediated protection correlated with an augmented number of NK cells (CD45+NK1.1+CD3-) and Iba-1+ microglial cells and a higher production of IFN-gamma in the brain. Poly I-C 0-9 interferon gamma Homo sapiens 151-160 31676069-6 2020 Treatment of KHYG-1 cells with leptomycin B, a specific XPO1 inhibitor, increased the expression of GrB and IFN-gamma but did not potentiate lysis of specific target cells, suggesting that the cargo of XPO1 contributes to the expression of cytolytic genes but that this alone is insufficient to enhance cytolysis. leptomycin B 31-43 interferon gamma Homo sapiens 108-117 31676069-7 2020 Consistent with this, nobiletin and related PMFs induced the nuclear retention of NF-kappaB, a transcription factor that promotes GrB and IFN-gamma expression. nobiletin 22-31 interferon gamma Homo sapiens 138-147 31676069-7 2020 Consistent with this, nobiletin and related PMFs induced the nuclear retention of NF-kappaB, a transcription factor that promotes GrB and IFN-gamma expression. flavone 44-48 interferon gamma Homo sapiens 138-147 31672285-3 2020 Here, we demonstrated that combretastatin A-4 phosphate (CA4P), a vascular disrupting agent (VDA), can significantly improve the infiltration ability of CAR-T cells in solid tumors as evidenced by elevated levels of IFN-gamma. fosbretabulin 57-61 interferon gamma Homo sapiens 216-225 31622780-4 2020 This work demonstrates a proof-of-concept theranostic approach for inflammation based on analyte-kissing induced signaling, whereby a drug (in this report, aspirin) can be released upon the detection of a target level of a proinflammatory cytokine (i.e., interferon-gamma (IFN-gamma)) in real time. Aspirin 156-163 interferon gamma Homo sapiens 255-271 31906962-10 2020 Interestingly, treatment with 7-OD enhanced Th1 responses by increasing Mtb-induced proliferation and the production of IFN-gamma and TNF-alpha over IL-10 levels. 7-oxodehydroepiandrosterone 30-34 interferon gamma Homo sapiens 120-129 32123858-7 2020 In LPS- and IFNgamma-induced pro-inflammatory macrophages, WP1066 strongly attenuated nitric-oxide release and expression of major inflammatory markers such as TNF-alpha, iNOS, CCL2, IL-1beta, IL-6, and CCR2. Nitric Oxide 86-98 interferon gamma Homo sapiens 12-20 31622780-9 2020 STATEMENT OF SIGNIFICANCE: We developed an adaptive in vivo sensing device whereby a drug, aspirin, can be released upon the detection of a proinflammatory cytokine, interferon-gamma (IFN-gamma), in real time with a sensitivity of 10 pg mL-1. Aspirin 91-98 interferon gamma Homo sapiens 184-193 31622780-4 2020 This work demonstrates a proof-of-concept theranostic approach for inflammation based on analyte-kissing induced signaling, whereby a drug (in this report, aspirin) can be released upon the detection of a target level of a proinflammatory cytokine (i.e., interferon-gamma (IFN-gamma)) in real time. Aspirin 156-163 interferon gamma Homo sapiens 273-282 31622780-9 2020 STATEMENT OF SIGNIFICANCE: We developed an adaptive in vivo sensing device whereby a drug, aspirin, can be released upon the detection of a proinflammatory cytokine, interferon-gamma (IFN-gamma), in real time with a sensitivity of 10 pg mL-1. Aspirin 91-98 interferon gamma Homo sapiens 166-182 31678681-11 2020 Indeed, treatment of human B cells with IFNgamma resulted in increased STAT3 serine phosphorylation and reversed TCDD-mediated suppression of the IgM response. cholecystokinin C-terminal flanking peptide 77-83 interferon gamma Homo sapiens 40-48 31596606-8 2020 To test the hypothesis that BPAF fosters vulnerabilities to STAT1 activation, we treated mature adipocytes previously exposed to BPAF with interferon gamma (IFNg). 4,4'-hexafluorisopropylidene diphenol 129-133 interferon gamma Homo sapiens 139-155 31596606-9 2020 BPAF increased IFNg activation of STAT1 and exposed mitochondrial vulnerabilities that disrupt adipocyte lipid and carbohydrate metabolism. 4,4'-hexafluorisopropylidene diphenol 0-4 interferon gamma Homo sapiens 15-19 33377367-8 2020 Zinc supplementation increased ex-vivo IFN-gamma production, greatest amongst boys, younger (<3.5 years), normal weight and children with low baseline retinol concentration. Vitamin A 151-158 interferon gamma Homo sapiens 39-48 33377367-9 2020 Vitamin A supplementation increased IFN-gamma only in those with low baseline retinol, with no effect on serum IgG and salivary IgA. Vitamin A 0-9 interferon gamma Homo sapiens 36-45 32475915-7 2020 Moreover, Ziyuglycoside II reversed RV-induced downregulation of anti-inflammatory cytokine interleukin (IL)-10 and upregulation of pro-inflammatory factors, such as interferon-gamma (IFN-gamma), IL-1beta, IL-6, and tumor necrosis factor (TNF-alpha). ziyuglycoside II 10-26 interferon gamma Homo sapiens 166-182 32475915-7 2020 Moreover, Ziyuglycoside II reversed RV-induced downregulation of anti-inflammatory cytokine interleukin (IL)-10 and upregulation of pro-inflammatory factors, such as interferon-gamma (IFN-gamma), IL-1beta, IL-6, and tumor necrosis factor (TNF-alpha). ziyuglycoside II 10-26 interferon gamma Homo sapiens 184-193 31678681-0 2020 TCDD-mediated suppression of naive human B cell IgM secretion involves aryl hydrocarbon receptor-mediated reduction in STAT3 serine 727 phosphorylation and is restored by Interferon-gamma. tcdd 0-4 interferon gamma Homo sapiens 171-187 31678681-11 2020 Indeed, treatment of human B cells with IFNgamma resulted in increased STAT3 serine phosphorylation and reversed TCDD-mediated suppression of the IgM response. tcdd 113-117 interferon gamma Homo sapiens 40-48 31678681-12 2020 Together, these data putatively identify a key event in the mechanism by which TCDD induces suppression of Ig secretion and demonstrate the potential of IFNgamma as a means to reverse this effect in primary human B lymphocytes. tcdd 79-83 interferon gamma Homo sapiens 153-161 31606902-5 2020 We show here that zoledronate readily induces upregulation of HLA-DR, CD40 and CD64 on monocytes from both healthy controls and sepsis patients, which could be abrogated by neutralising the pro-inflammatory cytokines interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha in the cultures. Zoledronic Acid 18-29 interferon gamma Homo sapiens 217-239 31969092-10 2020 Lupeol alone or in combination with approved drugs inhibits inflammation in different cancer cells through modulation of expression of IL-6, TNF-alpha, and IFN-gamma. lupeol 0-6 interferon gamma Homo sapiens 156-165 31655430-0 2020 N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-gamma induced PD-L1 expression. n-alkyl-hydroxybenzoyl anilide hydroxamates 0-43 interferon gamma Homo sapiens 97-106 31721311-7 2020 Furthermore, tofacitinib affected the response of differentiated DCs to maturation stimuli such as LPS and IFNgamma, resulting in a partial up-regulation of IL-23 and down-regulation of IL-12, as assessed by qPCR. tofacitinib 13-24 interferon gamma Homo sapiens 107-115 31784043-7 2020 PBMCs from seven donors (responders) produced high levels of IFN-gamma when re-exposed to CBZ, while eight donors (non-responders) did not. Carbamazepine 90-93 interferon gamma Homo sapiens 61-70 31894751-5 2020 Treatment with sertraline with or without ketoprofen significantly reduced the baseline levels of all biomarkers to levels which were in the normal range (IDO, TGF-beta1, and IL-4) or still somewhat higher than in controls (IFN-gamma). Sertraline 15-25 interferon gamma Homo sapiens 224-233 31894751-5 2020 Treatment with sertraline with or without ketoprofen significantly reduced the baseline levels of all biomarkers to levels which were in the normal range (IDO, TGF-beta1, and IL-4) or still somewhat higher than in controls (IFN-gamma). Ketoprofen 42-52 interferon gamma Homo sapiens 224-233 31472402-4 2020 TB-KDM individuals exhibit significantly higher levels of IFNgamma, IL-2, TNFalpha, IL-17A, IL-1alpha, IL-1beta and IL-6 in comparison to TB-NDM, TB alone and DM alone individuals. Terbium 0-2 interferon gamma Homo sapiens 58-66 31472402-7 2020 TB-NDM individuals are also characterized by significantly diminished TB-antigen stimulated levels of IFNgamma, IL-2, TNFalpha, IL-17A, IL-17F, IL-1alpha, IL-1beta and/or IL-6 at pre-treatment and at 2 months of ATT and IFNgamma, IL-2, IL-1alpha and IL-1beta at post-treatment. Terbium 0-2 interferon gamma Homo sapiens 102-110 31472402-7 2020 TB-NDM individuals are also characterized by significantly diminished TB-antigen stimulated levels of IFNgamma, IL-2, TNFalpha, IL-17A, IL-17F, IL-1alpha, IL-1beta and/or IL-6 at pre-treatment and at 2 months of ATT and IFNgamma, IL-2, IL-1alpha and IL-1beta at post-treatment. Terbium 0-2 interferon gamma Homo sapiens 221-229 31821937-4 2020 The results demonstrated that treatment with xanthone reduced the production of pro-inflammatory cytokines and chemokines including interleukin (IL)-1beta, IL-6, IL-8, and expression of chemokines thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma-stimulated HaCaT cells. Xanthones 45-53 interferon gamma Homo sapiens 326-348 31196739-1 2020 OBJECTIVE: The purpose of this prospective study was to assess the effects of selenium supplementation on TSH and interferon-gamma inducible chemokines (CXCL9, CXCL10 and CXCL11) levels in patients with subclinical hypothyroidism due to Hashimoto"s thyroiditis. Selenium 78-86 interferon gamma Homo sapiens 114-130 32385217-9 2020 MiR-140-3p addition mitigated IFN-gamma and TNF-alpha production induced via IL-2 as well as NK-92 cytotoxicity to OC cells. mir-140-3p 0-10 interferon gamma Homo sapiens 30-39 31385383-6 2020 Cytokine production of IFN-gamma and TNF-alpha on CD3- CD56+ NK cells in septic patients was also impaired after stimulation by PMA and ionomycin. Tetradecanoylphorbol Acetate 128-131 interferon gamma Homo sapiens 23-32 31385383-6 2020 Cytokine production of IFN-gamma and TNF-alpha on CD3- CD56+ NK cells in septic patients was also impaired after stimulation by PMA and ionomycin. Ionomycin 136-145 interferon gamma Homo sapiens 23-32 31520461-8 2020 SB203580-induced inhibition of p38MAPK phosphorylation was associated with suppression of IFN-gamma production in all groups. SB 203580 0-8 interferon gamma Homo sapiens 90-99 31675639-8 2020 We also found that monomethyl fumarate dampened T cell proliferation and reduced the frequency of TNF-alpha, IL-17 and IFN-gamma producing T cells. citraconic acid 19-38 interferon gamma Homo sapiens 119-128 32450553-5 2020 Proliferation and IFN-gamma production of circulating NKT cells in response to alpha-GalCer were markedly decreased in trauma patients. alpha-galactosylceramide 79-91 interferon gamma Homo sapiens 18-27 31945761-8 2020 From the 4th to 12th week after ESS, the IL-2, IFN-gamma, IL-4, and IL-17 levels in nasal secretions of the non-asthmatic group were significantly increased as compared to their baseline controls. ESS 32-35 interferon gamma Homo sapiens 47-56 31847340-0 2019 1,25(OH)2D3 Differently Affects Immunomodulatory Activities of Mesenchymal Stem Cells Depending on the Presence of TNF-alpha, IL-1beta and IFN-gamma. 25-hydroxyvitamin D3-bromoacetate 0-11 interferon gamma Homo sapiens 139-148 31536982-9 2020 Lubiprostone significantly reduced the IFNgamma-induced increase in FITC labeled-dextran permeability. Fluorescein-5-isothiocyanate 68-72 interferon gamma Homo sapiens 39-47 31536982-9 2020 Lubiprostone significantly reduced the IFNgamma-induced increase in FITC labeled-dextran permeability. Dextrans 81-88 interferon gamma Homo sapiens 39-47 31536982-12 2020 CONCLUSION: Lubiprostone significantly improved the IFNgamma-induced decrease in TEER and increase in FITC labeled-dextran permeability. Lubiprostone 12-24 interferon gamma Homo sapiens 52-60 31536982-12 2020 CONCLUSION: Lubiprostone significantly improved the IFNgamma-induced decrease in TEER and increase in FITC labeled-dextran permeability. Fluorescein-5-isothiocyanate 102-106 interferon gamma Homo sapiens 52-60 31536982-12 2020 CONCLUSION: Lubiprostone significantly improved the IFNgamma-induced decrease in TEER and increase in FITC labeled-dextran permeability. Dextrans 115-122 interferon gamma Homo sapiens 52-60 31852517-13 2019 The gamma-hexalactone only at 5.15 muM induced increase in the levels of IL-6 (~ 60%), TNF-alpha (~ 68%) and IFN-gamma (~ 29%), but decreased IL-10 (~ 46%) in comparison with the negative control (p < 0.05). 4-hexanolide 4-21 interferon gamma Homo sapiens 109-118 31853095-0 2019 N-Octanoyl-Dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNgamma-stimulated endothelial cells. N-octanoyldopamine 0-19 interferon gamma Homo sapiens 142-150 31853095-3 2019 We assessed if inhibition of T-cell activation by N-octanoyl dopamine (NOD) impairs adherence of activated T-cells to endothelial cells and the ability of activated T-cells to produce IFNgamma. N-octanoyldopamine 71-74 interferon gamma Homo sapiens 184-192 31930120-13 2019 Moreover, IFN-gamma, TNF-alpha, and perforin generated by CD8+ T cells could also be inhibited through the adenosine A2aR pathway. Adenosine 107-116 interferon gamma Homo sapiens 10-19 31536982-8 2020 Lubiprostone significantly improved the IFNgamma-induced decrease in TEER in a dose-dependent manner. Lubiprostone 0-12 interferon gamma Homo sapiens 40-48 31536982-9 2020 Lubiprostone significantly reduced the IFNgamma-induced increase in FITC labeled-dextran permeability. Lubiprostone 0-12 interferon gamma Homo sapiens 39-47 32270742-11 2020 The presence of the SIRT1 inhibitor, EX-527 negated [by 92 +- 12% (median +- SEM)] the effect of the SIRT1 activator SRT720 on the percentage of CD8+ T cells producing IFNgamma and TNFalpha. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 37-43 interferon gamma Homo sapiens 168-176 31852519-6 2019 Exposed cells then underwent RNA sequencing (RNAseq) to determine the effects of TX or CQ co-treatments on cellular response to IFN-gamma at a molecular level. Chloroquine 87-89 interferon gamma Homo sapiens 128-137 31694910-7 2019 With stimulation by PMA/ionomycin, TNF-alpha, or H2O2, PBMCs from ulcerative colitis patients treated with NX-13 had decreased NF-kappaB activity, TNF-alpha+ and IFN-gamma+ CD4+ T cells and overall production of IL-6, MCP1, and IL-8. Water 49-53 interferon gamma Homo sapiens 162-171 31847340-5 2019 Additionally, the effects of 1,25(OH)2D3 on TNF-alpha-, IL-1beta-, and IFN-gamma-induced gene expression of some immunomodulatory factors in hPDLSCs were compared. 25-hydroxyvitamin D3-bromoacetate 29-40 interferon gamma Homo sapiens 71-80 31847340-8 2019 With one exception, 1,25(OH)2D3 significantly reduced TNF-alpha-, IL-1beta-, and IFN-gamma-induced expression of all the investigated immunomediators in hPDLSCs, albeit to different extents. 25-hydroxyvitamin D3-bromoacetate 20-31 interferon gamma Homo sapiens 81-90 31456010-6 2019 The combination of mizolastine plus proteoglycan is effective in treating chronic urticaria with better therapeutic effect and lower relapse rate through promoting IFN-gamma production. mizolastine 19-30 interferon gamma Homo sapiens 164-173 31921116-7 2019 The influence of ibrutinib on antigen-specific CD8+ T cell function was assessed by HLA-peptide tetramers and revealed increased IFNgamma and TNFalpha cytokine responses following stimulation with CMV or EBV peptides together with a 55% reduction in the frequency of "inflated" virus-specific CD8+ T cells. ibrutinib 17-26 interferon gamma Homo sapiens 129-137 31051495-5 2019 RESULTS: Incubation of peripheral and intestinal T cells with 1,25(OH)2-vitD resulted in strongly reduced frequencies of pro-inflammatory CD4+ and CD8+ T cells producing IFNgamma, IL-17, IL-22, IL-9 and TNF. 1,25(oh)2-vitd 62-76 interferon gamma Homo sapiens 170-178 31921153-8 2019 In the alloantigen-induced response the production of IFNgamma, TNF-alpha, IL-13, IL-4, and TGF-beta1, were also significantly reduced in cultures with dexamethasone-treated DCs. Dexamethasone 152-165 interferon gamma Homo sapiens 54-62 31805854-10 2019 Dexmedetomidine decreased the concentration of eotaxin, interleukin-18, interleukin-2Ralpha, stem cell factor, stem cell growth factor and vascular endothelial growth factor, and propofol decreased significantly the levels of hepatocyte growth factor, IFN-gamma-induced protein 10 and monokine induced by IFN-gamma, and increased the levels of interleukin-17, interleukin-5, interleukin-7 and PDGF. Dexmedetomidine 0-15 interferon gamma Homo sapiens 252-261 31805854-10 2019 Dexmedetomidine decreased the concentration of eotaxin, interleukin-18, interleukin-2Ralpha, stem cell factor, stem cell growth factor and vascular endothelial growth factor, and propofol decreased significantly the levels of hepatocyte growth factor, IFN-gamma-induced protein 10 and monokine induced by IFN-gamma, and increased the levels of interleukin-17, interleukin-5, interleukin-7 and PDGF. Dexmedetomidine 0-15 interferon gamma Homo sapiens 305-314 31805854-10 2019 Dexmedetomidine decreased the concentration of eotaxin, interleukin-18, interleukin-2Ralpha, stem cell factor, stem cell growth factor and vascular endothelial growth factor, and propofol decreased significantly the levels of hepatocyte growth factor, IFN-gamma-induced protein 10 and monokine induced by IFN-gamma, and increased the levels of interleukin-17, interleukin-5, interleukin-7 and PDGF. Propofol 179-187 interferon gamma Homo sapiens 252-261 31805854-10 2019 Dexmedetomidine decreased the concentration of eotaxin, interleukin-18, interleukin-2Ralpha, stem cell factor, stem cell growth factor and vascular endothelial growth factor, and propofol decreased significantly the levels of hepatocyte growth factor, IFN-gamma-induced protein 10 and monokine induced by IFN-gamma, and increased the levels of interleukin-17, interleukin-5, interleukin-7 and PDGF. Propofol 179-187 interferon gamma Homo sapiens 305-314 31554642-5 2019 Mechanistically, IFNgamma derived from immunotherapy-activated CD8+ T cells and radiotherapy-activated ATM independently, yet synergistically repress SLC7A11, a unit of the glutamate-cystine antiporter xc-, resulting in reduced cystine uptake, enhanced tumor lipid oxidation and ferroptosis, and improved tumor control. Glutamic Acid 173-182 interferon gamma Homo sapiens 17-25 31007088-10 2019 In addition, mannose in the structure of MLCMNP improved IL-6, TNF-alpha and IFN-gamma (>16 fold) cytokines genes expression by macrophage/dendritic cells after exposure in 12 h. Immunization of experimental mice (subcutaneously, two times with 2-week intervals) with 5 microg of HBsAg loaded on MLCMNP nanoparticles increased specific total IgG and IgG2a/IgG1 ratio. Mannose 13-20 interferon gamma Homo sapiens 77-86 31577968-1 2019 In this work, a novel and signal-amplified label-free electrochemical aptasensor was developed and enabled efficient determination of gamma-interferon (IFN-gamma), based on target-induced DNA strand transform of hairpin-to-linear conformation combining with simultaneous capture of redox probe and target. Interferon-gamma 134-150 interferon gamma Homo sapiens 152-161 31577968-3 2019 HS-terminated hairpin-DNA aptamer of IFN-gamma was conjugated with AuNPs to prepare aptamer-AuNPs-PAMAM/MoS2 onto glassy carbon electrode (GCE), by using bovine serum albumin as the cross-linker and stabilizer. molybdenum disulfide 104-108 interferon gamma Homo sapiens 37-46 31577968-3 2019 HS-terminated hairpin-DNA aptamer of IFN-gamma was conjugated with AuNPs to prepare aptamer-AuNPs-PAMAM/MoS2 onto glassy carbon electrode (GCE), by using bovine serum albumin as the cross-linker and stabilizer. Carbon 121-127 interferon gamma Homo sapiens 37-46 31577968-4 2019 Methylene blue (MB) as a redox probe was absorbed on IFN-gamma aptamer. Methylene Chloride 0-9 interferon gamma Homo sapiens 53-62 31554642-5 2019 Mechanistically, IFNgamma derived from immunotherapy-activated CD8+ T cells and radiotherapy-activated ATM independently, yet synergistically repress SLC7A11, a unit of the glutamate-cystine antiporter xc-, resulting in reduced cystine uptake, enhanced tumor lipid oxidation and ferroptosis, and improved tumor control. Cystine 183-190 interferon gamma Homo sapiens 17-25 31554642-5 2019 Mechanistically, IFNgamma derived from immunotherapy-activated CD8+ T cells and radiotherapy-activated ATM independently, yet synergistically repress SLC7A11, a unit of the glutamate-cystine antiporter xc-, resulting in reduced cystine uptake, enhanced tumor lipid oxidation and ferroptosis, and improved tumor control. Cystine 228-235 interferon gamma Homo sapiens 17-25 31454491-6 2019 After being stimulated with ESAT-6 and CFP-10 antigens, the median frequency and proportion of IFN-gamma+IL-2- T cells were significantly higher in the ATB group than the non-ATB group (P < .001). atb 152-155 interferon gamma Homo sapiens 95-104 31454491-10 2019 In conclusion, IFN-gamma/IL-2 FluoroSpot assay is conducive for the diagnosis of ATB in patients with positive T-SPOT.TB results. Terbium 82-84 interferon gamma Homo sapiens 15-24 31575437-4 2019 Using particulate PMMA, a material that resembled wear debris in orthopedic implants, to stimulate whole peripheral blood mononuclear cells, we found that the expression of IFNgamma, IL-4, IL-17, and TGFbeta could all be upregulated in CD4 T cells in a manner that was dependent on the dose of particulate PMMA. Polymethyl Methacrylate 18-22 interferon gamma Homo sapiens 173-181 31575437-4 2019 Using particulate PMMA, a material that resembled wear debris in orthopedic implants, to stimulate whole peripheral blood mononuclear cells, we found that the expression of IFNgamma, IL-4, IL-17, and TGFbeta could all be upregulated in CD4 T cells in a manner that was dependent on the dose of particulate PMMA. Polymethyl Methacrylate 306-310 interferon gamma Homo sapiens 173-181 31575437-5 2019 Furthermore, compared to direct anti-CD3/CD28 stimulation, PMMA preferentially stimulated the expression of IFNgamma and IL-17 but not the expression of IL-4 or TGFbeta. Polymethyl Methacrylate 59-63 interferon gamma Homo sapiens 108-116 31711939-10 2019 We found that caffeine and anti-PD1 mAb combination therapy significantly increased intra-tumoral TNF-alpha and IFN-gamma levels. Caffeine 14-22 interferon gamma Homo sapiens 112-121 31703604-12 2019 Clinically, these findings were confirmed in patients with advanced melanoma treated with domatinostat for 14 days, who demonstrated elevated expression of APM and MHC genes, the IFNG gene, and the IFN-gamma and pembrolizumab response signatures in individual tumor samples. domatinostat 90-102 interferon gamma Homo sapiens 179-183 31679846-9 2019 In the SPL, enrofloxacin treatment increased the secretion of TGF-beta and IL-10 and decreased the secretion of IL-17A and IFN-gamma. enrofloxacin 12-24 interferon gamma Homo sapiens 123-132 31548239-4 2019 We found that the induction of cell surface MHCI and MHCII molecules by IFNgamma is enhanced by the clinical grade PI3K inhibitors dactolisib and pictilisib. dactolisib 131-141 interferon gamma Homo sapiens 72-80 31548239-4 2019 We found that the induction of cell surface MHCI and MHCII molecules by IFNgamma is enhanced by the clinical grade PI3K inhibitors dactolisib and pictilisib. 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine 146-156 interferon gamma Homo sapiens 72-80 31915457-4 2019 The SJZDP, S-3, and S-3-AG all showed strong capability to stimulate Peyer"s patch cells to proliferate and produce IgA and promoted the proliferation and IFN-gamma production of splenocytes and increased the NO production and TNF-alpha production of macrophages. sjzdp 4-9 interferon gamma Homo sapiens 155-164 31915457-4 2019 The SJZDP, S-3, and S-3-AG all showed strong capability to stimulate Peyer"s patch cells to proliferate and produce IgA and promoted the proliferation and IFN-gamma production of splenocytes and increased the NO production and TNF-alpha production of macrophages. Sulfur 11-14 interferon gamma Homo sapiens 155-164 31915457-4 2019 The SJZDP, S-3, and S-3-AG all showed strong capability to stimulate Peyer"s patch cells to proliferate and produce IgA and promoted the proliferation and IFN-gamma production of splenocytes and increased the NO production and TNF-alpha production of macrophages. Sulfur 20-26 interferon gamma Homo sapiens 155-164 31771091-5 2019 A variety of cell culture studies have shown that ZnO NP can induce cytokines such as IFN-gamma, TNF-alpha, IL-2, and IL-12 which are known to regulate the tumor microenvironment. zno np 50-56 interferon gamma Homo sapiens 86-95 31732450-3 2019 Pretreating T cells for 24 h with BAY 41-2272 at 3 muM and 30 muM, followed by activation with 90 nM phorbol myristate acetate (PMA), inhibited interferon-gamma (IFN-gamma) production, with 3 muM and 30 muM BAY causing 16.5-fold and 12.1-fold inhibition, respectively, compared to PMA alone (p < 0.05, one-way ANOVA followed by Tukey"s test). 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine 34-45 interferon gamma Homo sapiens 144-160 31732450-3 2019 Pretreating T cells for 24 h with BAY 41-2272 at 3 muM and 30 muM, followed by activation with 90 nM phorbol myristate acetate (PMA), inhibited interferon-gamma (IFN-gamma) production, with 3 muM and 30 muM BAY causing 16.5-fold and 12.1-fold inhibition, respectively, compared to PMA alone (p < 0.05, one-way ANOVA followed by Tukey"s test). 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine 34-45 interferon gamma Homo sapiens 162-171 31732450-3 2019 Pretreating T cells for 24 h with BAY 41-2272 at 3 muM and 30 muM, followed by activation with 90 nM phorbol myristate acetate (PMA), inhibited interferon-gamma (IFN-gamma) production, with 3 muM and 30 muM BAY causing 16.5-fold and 12.1-fold inhibition, respectively, compared to PMA alone (p < 0.05, one-way ANOVA followed by Tukey"s test). Tetradecanoylphorbol Acetate 101-126 interferon gamma Homo sapiens 162-171 31732450-3 2019 Pretreating T cells for 24 h with BAY 41-2272 at 3 muM and 30 muM, followed by activation with 90 nM phorbol myristate acetate (PMA), inhibited interferon-gamma (IFN-gamma) production, with 3 muM and 30 muM BAY causing 16.5-fold and 12.1-fold inhibition, respectively, compared to PMA alone (p < 0.05, one-way ANOVA followed by Tukey"s test). Tetradecanoylphorbol Acetate 128-131 interferon gamma Homo sapiens 144-160 31732450-3 2019 Pretreating T cells for 24 h with BAY 41-2272 at 3 muM and 30 muM, followed by activation with 90 nM phorbol myristate acetate (PMA), inhibited interferon-gamma (IFN-gamma) production, with 3 muM and 30 muM BAY causing 16.5-fold and 12.1-fold inhibition, respectively, compared to PMA alone (p < 0.05, one-way ANOVA followed by Tukey"s test). Tetradecanoylphorbol Acetate 128-131 interferon gamma Homo sapiens 162-171 31732450-3 2019 Pretreating T cells for 24 h with BAY 41-2272 at 3 muM and 30 muM, followed by activation with 90 nM phorbol myristate acetate (PMA), inhibited interferon-gamma (IFN-gamma) production, with 3 muM and 30 muM BAY causing 16.5-fold and 12.1-fold inhibition, respectively, compared to PMA alone (p < 0.05, one-way ANOVA followed by Tukey"s test). Tetradecanoylphorbol Acetate 281-284 interferon gamma Homo sapiens 162-171 31187242-5 2019 Moreover, the expression of IL-2 and IFN-gamma was significantly upregulated in vitro and in vivo after SElQ treatment. selq 104-108 interferon gamma Homo sapiens 37-46 31267172-4 2019 Upon microbial infection, interferon gamma (IFN-gamma), a major cytokine of the adaptive immune response, induces a broad spectrum of effector molecules, such as the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase-1 (IDO1). Tryptophan 166-176 interferon gamma Homo sapiens 26-53 31582218-0 2019 Intranasal vaccination with HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody, anti-HBs IgA, and IFNG response. carboxyl vinyl polymer 62-84 interferon gamma Homo sapiens 141-145 31442384-6 2019 The recovery amount of the fusion protein found to be dependent on the NaCl concentration, with increase of NaCl concentration, a greater fraction of the hIFN-gamma-ELP was aggregated. Sodium Chloride 71-75 interferon gamma Homo sapiens 154-164 31442384-6 2019 The recovery amount of the fusion protein found to be dependent on the NaCl concentration, with increase of NaCl concentration, a greater fraction of the hIFN-gamma-ELP was aggregated. Sodium Chloride 108-112 interferon gamma Homo sapiens 154-164 31442384-7 2019 However, due to the presence of an aliphatic guest residue in ELP sequence, the high concentration of salt was necessary to trigger the inverse phase transition of hIFN-gamma-ELP fusion protein. Salts 102-106 interferon gamma Homo sapiens 164-174 31798578-2 2019 Although there are only a few reports on interdependency of their actions, the interplay between IFN-gamma and vit D3 has been clearly demonstrated in certain aspects of immune reactivity. Cholecalciferol 111-117 interferon gamma Homo sapiens 97-106 31798578-4 2019 Combined treatment with vit D3 and IFN-gamma caused an extensive expression of immunoglobulin-like transcript (ILT)-3 and programmed death ligand (PDL)-1 on gamma/D3DCs, significantly greater than that caused by vit D3 alone. Cholecalciferol 212-218 interferon gamma Homo sapiens 35-44 31718684-12 2019 RESULTS: We found that ALCAR reduces cell proliferation, induces apoptosis, hinders the production of pro inflammatory cytokines (TNF-alpha and IFN-gamma) and of chemokines CCL2, CXCL12 and receptor CXCR4 involved in the chemotactic axis and impairs the adhesion, migration and invasion capabilities of PCa and BPH cells in vitro. Acetylcarnitine 23-28 interferon gamma Homo sapiens 144-153 31815149-4 2019 Superoxide generation was assessed by L-012-enhanced chemiluminescence and was increased in both M(IFN-gamma+LPS) and M(IL-4) macrophages, as compared to unpolarised macrophages (MPhi). Superoxides 0-10 interferon gamma Homo sapiens 99-108 31703604-12 2019 Clinically, these findings were confirmed in patients with advanced melanoma treated with domatinostat for 14 days, who demonstrated elevated expression of APM and MHC genes, the IFNG gene, and the IFN-gamma and pembrolizumab response signatures in individual tumor samples. domatinostat 90-102 interferon gamma Homo sapiens 198-207 31284015-6 2019 Interestingly, higher IFNgamma serum levels were observed in the LPS/CUMS + group, which were further correlated with reduced sucrose consumption. Sucrose 126-133 interferon gamma Homo sapiens 22-30 32002296-7 2020 Peripheral blood mononuclear cells (PBMCs) secreted high levels of CXCL10, CCL2 and IFN-gamma in response to co-culture with melphalan-exposed melanoma cells in vitro. Melphalan 125-134 interferon gamma Homo sapiens 84-93 31506179-7 2019 Though IFN-gamma treatment slightly reduced the migration ability of MSCs cultured on glass or poly(lactic-co-glycolic acid) (PLGA) nanofiber sheets, it did not alter MSC motility on SFN sheets. Polylactic Acid-Polyglycolic Acid Copolymer 95-124 interferon gamma Homo sapiens 7-16 31930074-9 2019 Antifungal treatment could decrease the level of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha and interferon-gamma in CTG than in CNTG (P<0.05, respectively). ctg 135-138 interferon gamma Homo sapiens 115-131 31704852-1 2019 BACKGROUND/AIM: The present study aimed to prospectively examine the usefulness of interferon-gamma (IFN-gamma) release (IGR) as a biomarker in non-small-cell lung cancer patients receiving immune checkpoint inhibitor treatment (ICI-Tx). Tx2 neurotoxin 229-235 interferon gamma Homo sapiens 83-99 31704852-7 2019 CONCLUSION: IFN-gamma levels could be a biomarker for ICI-Tx. 2-I-ICI-H 54-57 interferon gamma Homo sapiens 12-21 31696912-1 2019 Monokine induced by interferon (IFN)-gamma (MIG) and its receptor chemokine (C-X-C motif) receptor 3 (CXCR)3 seem to play an important role in the pathogenesis of rheumatoid arthritis (RA). Monokines 0-8 interferon gamma Homo sapiens 20-42 30957844-7 2019 Applying SmCCNet to studies on chronic obstructive pulmonary disease (COPD) and breast cancer, we found enrichment of known relevant pathways (e.g. the Cadherin pathway for COPD and the interferon-gamma signaling pathway for breast cancer) as well as less known omics features that may be important to the diseases. smccnet 9-16 interferon gamma Homo sapiens 186-202 31489989-2 2019 Immune activation after stimulation with interferon-gamma leads to increased production of neopterin but also results in increased tryptophan catabolism through indoleamine 2,3-dioxygenase (IDO). Neopterin 91-100 interferon gamma Homo sapiens 41-57 31631469-6 2019 The expression of TNF-alpha was downregulated during therapy, IL23A was upregulated during CsA treatment, while the expression of IFN-gamma and IL17 were higher after 42 days and lower after 84 days compared to 0 days of CsA treatment. Cyclosporine 221-224 interferon gamma Homo sapiens 130-139 31489989-2 2019 Immune activation after stimulation with interferon-gamma leads to increased production of neopterin but also results in increased tryptophan catabolism through indoleamine 2,3-dioxygenase (IDO). Tryptophan 131-141 interferon gamma Homo sapiens 41-57 31636696-6 2019 We further characterized increases of both mature dendritic cells and cytotoxic T cells in xenograft tumor in response to resveratrol treatment, which also inhibited TGF-beta production and stimulated both IL12p7 and IFN-gamma secretion. resveratrol 122-133 interferon gamma Homo sapiens 217-226 31525636-12 2019 Moreover, GSI stimulation not only promoted perforin, granzyme B, and FasL mRNA expression in CD8+ T cells, but also elevated CD8+ T cell-induced target cell death and IFN-gamma/TNF-alpha production in sepsis and septic shock. 2-(5-Chlorothiophen-2-Yl)-N-[(3s)-1-(4-{2-[(Dimethylamino)methyl]-1h-Imidazol-1-Yl}-2-Fluorophenyl)-2-Oxopyrrolidin-3-Yl]ethanesulfonamide 10-13 interferon gamma Homo sapiens 168-177 31915712-10 2019 Our findings show that SC significantly decreased the percentage of T cells producing TNF-alpha and displayed tendency to decrease IFN-gamma, when stimulated with PMA. sildenafil 23-25 interferon gamma Homo sapiens 131-140 31915712-10 2019 Our findings show that SC significantly decreased the percentage of T cells producing TNF-alpha and displayed tendency to decrease IFN-gamma, when stimulated with PMA. Tetradecanoylphorbol Acetate 163-166 interferon gamma Homo sapiens 131-140 31625291-7 2019 Participants were tested with tuberculin skin test (TST) and T-SPOT.TB (an interferon gamma release assay) simultaneously. Terbium 68-70 interferon gamma Homo sapiens 75-91 31427448-6 2019 IFN-gamma signaling via the IFN-gamma-like receptor enhanced Eh erythrophagocytosis of human red blood cells that was abrogated with the STAT1 inhibitor, fludarabine. fludarabine 154-165 interferon gamma Homo sapiens 0-9 31427448-6 2019 IFN-gamma signaling via the IFN-gamma-like receptor enhanced Eh erythrophagocytosis of human red blood cells that was abrogated with the STAT1 inhibitor, fludarabine. fludarabine 154-165 interferon gamma Homo sapiens 28-37 31669719-6 2019 At the effective concentrations, geraniol also inhibited cytokine secretion of activated human T cells, including IL-2, TNF-alpha and IFN-gamma. geraniol 33-41 interferon gamma Homo sapiens 134-143 31553301-15 2019 ML1899 enhanced ROS/NO production and up-regulated pro-inflammatory cytokines and chemokine including TNF-alpha, IFN-gamma, IL-6 and IL-8 in macrophages. A 1899 0-6 interferon gamma Homo sapiens 113-122 31827897-3 2019 Therapeutic response displayed an interesting clinical correlation validated by PET scan images showing decreased fluorodeoxyglucose (FDG) avidity in the prostate gland, reduced skeletal metastases further established by the drop in serum Prostate Specific Antigen (PSA) levels and expression of immune assessment markers (IFN-gamma, Tregs, neutrophil lymphocyte ratio and platelet lymphocyte ratio). Fluorodeoxyglucose F18 134-137 interferon gamma Homo sapiens 323-332 31780862-6 2019 Serum IL-35 levels were significantly increased and serum levels of TNF-alpha, IL-17, IL-6, and IFN-gamma were significantly reduced in response to tofacitinib since week 4. tofacitinib 148-159 interferon gamma Homo sapiens 96-105 31624262-5 2019 Interestingly, numbers of IFN-gamma+ CD4+ T cells and serum IFN-gamma levels increased with the addition of sirolimus treatment likely promoting ongoing anti-PD-1 efficacy. Sirolimus 108-117 interferon gamma Homo sapiens 26-35 31622282-9 2019 The serum IFN-gamma concentrations in group Ba were significantly lower than those in groups Cn, Ca, Bn; P<0.05. Barium 44-46 interferon gamma Homo sapiens 10-19 31624262-5 2019 Interestingly, numbers of IFN-gamma+ CD4+ T cells and serum IFN-gamma levels increased with the addition of sirolimus treatment likely promoting ongoing anti-PD-1 efficacy. Sirolimus 108-117 interferon gamma Homo sapiens 60-69 31444999-14 2019 Ponatinib treatment significantly increased plasma VEGF, soluble (s)VEGFR1, sVEGFR2, sTIE2, interferon gamma (IFNgamma), tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-8, and IL-10 and decreased sVEGFR2. ponatinib 0-9 interferon gamma Homo sapiens 92-108 31274211-8 2019 Compared to placebo, vitamin D had significant decreasing effects on serum TNF-alpha, IFN-gamma, and IL12p70 levels, but it had no significant effect on serum levels of IL4 and IL10. Vitamin D 21-30 interferon gamma Homo sapiens 86-95 31377576-8 2019 In addition, the biosensor was able to detect IFN-gamma in serum samples successfully, which is expected to provide an efficient method for TB diagnosis at early stages. Terbium 140-142 interferon gamma Homo sapiens 46-55 31649684-7 2019 Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells. Tetradecanoylphorbol Acetate 175-206 interferon gamma Homo sapiens 116-125 30692641-4 2019 We reveal a novel mechanism of action of EZH2 inhibition, alone and in combination with cisplatin, which induces immune signaling with the largest changes observed in interferon gamma (IFN-gamma). Cisplatin 88-97 interferon gamma Homo sapiens 167-194 31606777-10 2019 Increased antigen-specific T-cell response, as measured by IFNgamma release, to the vaccine target antigen was detected following in vitro stimulation of peripheral blood cells with 1-methyltryptophan. technetium Tc 99m pyridoxyl-5-methyltryptophan 182-200 interferon gamma Homo sapiens 59-67 31444999-14 2019 Ponatinib treatment significantly increased plasma VEGF, soluble (s)VEGFR1, sVEGFR2, sTIE2, interferon gamma (IFNgamma), tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-8, and IL-10 and decreased sVEGFR2. ponatinib 0-9 interferon gamma Homo sapiens 110-118 31228643-9 2019 Additionally, our synthetic peptides and pools showed higher frequencies of IFN-gamma+CD4 and IFN-gamma+CD8 T cells than the peptides of Ag85B. Peptides 28-36 interferon gamma Homo sapiens 76-85 30473441-6 2019 RESULTS: Fixed effect analysis of the WMD (95% CI) of the changes in gene expression showed that gene expression of the inflammatory (IL-17, IFN-gamma and T-bet) and anti-inflammatory (TGF-beta and FOXP3) cytokines significantly decreased and increased due to vitamin A supplementation in patients with autoimmune (Multiple sclerosis and atherosclerosis) diseases. Vitamin A 260-269 interferon gamma Homo sapiens 141-150 31044626-10 2019 Furthermore, the capacity of ILT4+CD1c+ subset producing IFN-gamma was lower than ILT4- CD1c subset in PBMC of HCC patients following Poly I:C stimulation. Poly I-C 134-142 interferon gamma Homo sapiens 57-66 31625364-1 2019 BACKGROUND: Interferon-gamma release assay (T-SPOT.TB) has the theoretical possibility of discriminating TB from most non-tuberculous mycobacteria (NTM) infections, but there are limited reports on the use of T-SPOT.TB for diseases due to NTM in high TB burden country. Terbium 51-53 interferon gamma Homo sapiens 12-28 31625364-1 2019 BACKGROUND: Interferon-gamma release assay (T-SPOT.TB) has the theoretical possibility of discriminating TB from most non-tuberculous mycobacteria (NTM) infections, but there are limited reports on the use of T-SPOT.TB for diseases due to NTM in high TB burden country. Terbium 105-107 interferon gamma Homo sapiens 12-28 31228643-9 2019 Additionally, our synthetic peptides and pools showed higher frequencies of IFN-gamma+CD4 and IFN-gamma+CD8 T cells than the peptides of Ag85B. Peptides 28-36 interferon gamma Homo sapiens 94-103 31362059-7 2019 Additionally, IL-9Rhigh CD8+ T cells following anti-TCR and PMA + ionomycin stimulation presented higher IL-2 and IL-17 expression, and lower IFN-gamma expression, than IL-9Rlow CD8+ T cells. Tetradecanoylphorbol Acetate 60-63 interferon gamma Homo sapiens 142-151 31362059-7 2019 Additionally, IL-9Rhigh CD8+ T cells following anti-TCR and PMA + ionomycin stimulation presented higher IL-2 and IL-17 expression, and lower IFN-gamma expression, than IL-9Rlow CD8+ T cells. Ionomycin 66-75 interferon gamma Homo sapiens 142-151 31356684-3 2019 Interferon gamma (IFN-gamma), on the other hand, increases melatonin synthesis. Melatonin 59-68 interferon gamma Homo sapiens 0-16 31356684-0 2019 STAT1-NFkappaB crosstalk triggered by interferon gamma regulates noradrenaline-induced pineal hormonal production. Norepinephrine 65-78 interferon gamma Homo sapiens 38-54 30499912-8 2019 Th IL-2 and IFN-gamma percentages were significantly lowered with MDMP treatment (P<0.05). 2-(4-methyl-2,6-dinitroanilino)-N-methylpropionamide 66-70 interferon gamma Homo sapiens 12-21 30499912-9 2019 IFN-gamma/IL-4 ratio was also lowered with the MDMP treatment (P<0.05). 2-(4-methyl-2,6-dinitroanilino)-N-methylpropionamide 47-51 interferon gamma Homo sapiens 0-9 31356684-3 2019 Interferon gamma (IFN-gamma), on the other hand, increases melatonin synthesis. Melatonin 59-68 interferon gamma Homo sapiens 18-27 31356684-7 2019 Moreover, IFN-gamma treatment increased NA-induced Aanat transcription, in addition to the synthesis of N-acetylserotonin (NAS) and melatonin. N-acetylserotonin 104-121 interferon gamma Homo sapiens 10-19 31356684-7 2019 Moreover, IFN-gamma treatment increased NA-induced Aanat transcription, in addition to the synthesis of N-acetylserotonin (NAS) and melatonin. N-acetylserotonin 123-126 interferon gamma Homo sapiens 10-19 31356684-7 2019 Moreover, IFN-gamma treatment increased NA-induced Aanat transcription, in addition to the synthesis of N-acetylserotonin (NAS) and melatonin. Melatonin 132-141 interferon gamma Homo sapiens 10-19 30610351-7 2019 RESULTS: EtOH induced TLR3, IFNbeta, and IFNgamma in SH-SY5Y neurons and U373 astrocytes, but not in BV2 microglia. Ethanol 9-13 interferon gamma Homo sapiens 41-49 31100416-3 2019 The IFNgamma-CSA fusion possessed potent anti-viral assay against vesicular stomatitis virus in cultured cells. Cyclosporine 13-16 interferon gamma Homo sapiens 4-12 31100416-4 2019 IFNgamma-CSA was also stable at 37 C up to 72 h compared with 8 h for IFNgamma alone. Cyclosporine 9-12 interferon gamma Homo sapiens 0-8 31293088-0 2019 Preconditioning with interleukin-1 beta and interferon-gamma enhances the efficacy of human umbilical cord blood-derived mesenchymal stem cells-based therapy via enhancing prostaglandin E2 secretion and indoleamine 2,3-dioxygenase activity in dextran sulfate sodium-induced colitis. Dinoprostone 172-188 interferon gamma Homo sapiens 44-60 31293088-0 2019 Preconditioning with interleukin-1 beta and interferon-gamma enhances the efficacy of human umbilical cord blood-derived mesenchymal stem cells-based therapy via enhancing prostaglandin E2 secretion and indoleamine 2,3-dioxygenase activity in dextran sulfate sodium-induced colitis. Dextran Sulfate 243-265 interferon gamma Homo sapiens 44-60 31898601-0 2019 Effects of nitric oxide donor N,N"-di-sec-butyl-N,N"-dinitroso-1,4-phenylenediamine on the expression of interferon-gamma in tumor infiltrating lymphocytes. Nitric Oxide 11-23 interferon gamma Homo sapiens 105-121 31898601-0 2019 Effects of nitric oxide donor N,N"-di-sec-butyl-N,N"-dinitroso-1,4-phenylenediamine on the expression of interferon-gamma in tumor infiltrating lymphocytes. n,n"-di-sec-butyl-n,n"-dinitroso-1,4-phenylenediamine 30-83 interferon gamma Homo sapiens 105-121 31607286-5 2019 ELISA results indicated that IFN-gamma and TNF-beta release were significantly increased after oridonin treatment (P<0.05), however, the TNF-alpha release was not statistically different in comparison with control group (P>0.05). oridonin 95-103 interferon gamma Homo sapiens 29-38 31583075-4 2019 The results confirmed that H4R has the functional effects of mediating cytokine production (i.e., down-regulating IFN-gamma and up-regulating IL-6) in cells from a monocyte cell line following challenge with histamine. Histamine 208-217 interferon gamma Homo sapiens 114-123 31620662-4 2019 This study indicates that IFN-gamma causes an increase in glycolytic activity and uncoupling of glycolysis to tricarboxylic acid cycle and hence, the glycolytic metabolites and intermediates can be funneled toward the production of anti-inflammatory modulators indoleamine-2,3-dioxygenase and PGE2. Tricarboxylic Acids 110-128 interferon gamma Homo sapiens 26-35 31620662-4 2019 This study indicates that IFN-gamma causes an increase in glycolytic activity and uncoupling of glycolysis to tricarboxylic acid cycle and hence, the glycolytic metabolites and intermediates can be funneled toward the production of anti-inflammatory modulators indoleamine-2,3-dioxygenase and PGE2. 1H-indol-2-amine 261-272 interferon gamma Homo sapiens 26-35 31620662-4 2019 This study indicates that IFN-gamma causes an increase in glycolytic activity and uncoupling of glycolysis to tricarboxylic acid cycle and hence, the glycolytic metabolites and intermediates can be funneled toward the production of anti-inflammatory modulators indoleamine-2,3-dioxygenase and PGE2. Dinoprostone 293-297 interferon gamma Homo sapiens 26-35 31607286-6 2019 CONCLUSION: Oridonin can significantly improve killing efficiency of NK-92 MI on THP1, that might be related with up-regulation of MICB, ULBP1 and ULBP2 expression and promotion of IFN-gamma and TNF-beta release. oridonin 12-20 interferon gamma Homo sapiens 181-190 31310752-11 2019 We found that TNF-alpha and IFN-gamma levels were significantly higher in caffeine-treated groups. Caffeine 74-82 interferon gamma Homo sapiens 28-37 31391228-7 2019 Interferon gamma (IFN-gamma) values in response to TB antigen and mitogen were significantly higher in children than in adults (TB antigen, median of 10 versus 1.66 IU IFN-gamma/ml; mitogen, median of 10 versus 6.70 IU IFN-gamma/ml; P < 0.0001). tb antigen 51-61 interferon gamma Homo sapiens 0-16 31391228-7 2019 Interferon gamma (IFN-gamma) values in response to TB antigen and mitogen were significantly higher in children than in adults (TB antigen, median of 10 versus 1.66 IU IFN-gamma/ml; mitogen, median of 10 versus 6.70 IU IFN-gamma/ml; P < 0.0001). tb antigen 51-61 interferon gamma Homo sapiens 18-27 31551774-5 2019 Animal research further indicated, at the 3rd and 7th days after infection, LEP and DPEP significantly attenuated lung injury, decreased lung index, virus load in the lung and the level of IL-1beta in serum, inhibited the mRNA expression levels of TNF-alpha, TLR3, TLR4, TLR7, MyD88, NF-kappaB p65 and RIG-1 as well as the protein expression levels of TLR4, TLR7, MyD88 and NF-kappaB p65 and markedly increased thymus index, the level of IL-10 in serum and the mRNA expression level of IFN-gamma. Ephedrine 76-79 interferon gamma Homo sapiens 486-495 31540162-7 2019 In addition, fisetin treatment significantly decreased the secretion of Th1/Th-17 pro-inflammatory cytokines, particularly IFN-gamma and IL-17A by 12-O-tetradecanolylphorbol 13-acetate (TPA)-stimulated NHEKs and anti-CD3/CD28-activated human PBMCs. fisetin 13-20 interferon gamma Homo sapiens 123-132 31540162-7 2019 In addition, fisetin treatment significantly decreased the secretion of Th1/Th-17 pro-inflammatory cytokines, particularly IFN-gamma and IL-17A by 12-O-tetradecanolylphorbol 13-acetate (TPA)-stimulated NHEKs and anti-CD3/CD28-activated human PBMCs. 12-o-tetradecanolylphorbol 13-acetate 147-184 interferon gamma Homo sapiens 123-132 31594149-1 2019 Objective: To investigate the influence of IFN-gamma and IL-12 levels in prenatal peripheral blood of HBsAg-positive parturients on intrauterine transmission of hepatitis B virus (HBV). Hepatitis B Surface Antigens 102-107 interferon gamma Homo sapiens 43-52 31594149-8 2019 The level of IFN-gamma in peripheral blood of HBsAg-negative parturients was significantly lower than those of HBsAg-positive parturients (t=-2.55, P=0.011), NBIT group (t=-2.54, P=0.012) and OBI group (t=-2.33, P=0.021). Hepatitis B Surface Antigens 46-51 interferon gamma Homo sapiens 13-22 31594149-8 2019 The level of IFN-gamma in peripheral blood of HBsAg-negative parturients was significantly lower than those of HBsAg-positive parturients (t=-2.55, P=0.011), NBIT group (t=-2.54, P=0.012) and OBI group (t=-2.33, P=0.021). Hepatitis B Surface Antigens 111-116 interferon gamma Homo sapiens 13-22 31594149-14 2019 Conclusions: HBV can stimulate the expression of IFN-gamma and inhibit the secretion of IL-12 in pregnant and lying-in women, but the expression of IFN-gamma in HBsAg-positive parturients showed intra-group differentiation, and the maternal level of IFN-gamma will decrease in HBeAg-positive and high-HBV DNA loadstatus. Hepatitis B Surface Antigens 161-166 interferon gamma Homo sapiens 148-157 31594149-14 2019 Conclusions: HBV can stimulate the expression of IFN-gamma and inhibit the secretion of IL-12 in pregnant and lying-in women, but the expression of IFN-gamma in HBsAg-positive parturients showed intra-group differentiation, and the maternal level of IFN-gamma will decrease in HBeAg-positive and high-HBV DNA loadstatus. Hepatitis B Surface Antigens 161-166 interferon gamma Homo sapiens 148-157 31594149-14 2019 Conclusions: HBV can stimulate the expression of IFN-gamma and inhibit the secretion of IL-12 in pregnant and lying-in women, but the expression of IFN-gamma in HBsAg-positive parturients showed intra-group differentiation, and the maternal level of IFN-gamma will decrease in HBeAg-positive and high-HBV DNA loadstatus. Hepatitis B e Antigens 277-282 interferon gamma Homo sapiens 148-157 31594149-14 2019 Conclusions: HBV can stimulate the expression of IFN-gamma and inhibit the secretion of IL-12 in pregnant and lying-in women, but the expression of IFN-gamma in HBsAg-positive parturients showed intra-group differentiation, and the maternal level of IFN-gamma will decrease in HBeAg-positive and high-HBV DNA loadstatus. Hepatitis B e Antigens 277-282 interferon gamma Homo sapiens 148-157 31594149-15 2019 Increasing the levels of IFN-gamma and IL-12 in HBsAg-positive parturients is beneficial to block intrauterine transmission of HBV, especially DBI. Hepatitis B Surface Antigens 48-53 interferon gamma Homo sapiens 25-34 31460746-6 2019 To slow the release of soluble SDF-1alpha, we copolymerized methacrylated heparin with methacrylamide chitosan (MAC), to which we tethered IFN-gamma. methacrylamide chitosan 87-110 interferon gamma Homo sapiens 139-148 31511015-0 2019 Interferon-gamma enhances the antifibrotic effects of pirfenidone by attenuating IPF lung fibroblast activation and differentiation. pirfenidone 54-65 interferon gamma Homo sapiens 0-16 31646108-9 2019 In vivo experiments revealed synergistic improved overall survival and enhanced inhibition of tumor growth upon co-treatment with dichloroacetate (DCA), a PDK inhibitor, and PD-L1 antibody, accompanied by increased IFN-gamma secretion by monocytes infiltrating tumor islets. Dichloroacetic Acid 130-145 interferon gamma Homo sapiens 215-224 31646108-9 2019 In vivo experiments revealed synergistic improved overall survival and enhanced inhibition of tumor growth upon co-treatment with dichloroacetate (DCA), a PDK inhibitor, and PD-L1 antibody, accompanied by increased IFN-gamma secretion by monocytes infiltrating tumor islets. Dichloroacetic Acid 147-150 interferon gamma Homo sapiens 215-224 31274210-10 2019 GSI-stimulated CD14+ monocytes from chronic hepatitis C patients induced suppression of HCV RNA replication in both direct and indirect contact co-culture system of CD14+ monocytes and HCVcc-infected Huh7.5 cells, and this process was accompanied by elevation of interferon-gamma production but not increased target cell death. 2-(5-Chlorothiophen-2-Yl)-N-[(3s)-1-(4-{2-[(Dimethylamino)methyl]-1h-Imidazol-1-Yl}-2-Fluorophenyl)-2-Oxopyrrolidin-3-Yl]ethanesulfonamide 0-3 interferon gamma Homo sapiens 263-279 31551929-9 2019 Exposure to BPA significantly increased CD4+ T cells, IFNgamma, IL-17A, TLR4, caspase-1, and IL-1beta in the heart. bisphenol A 12-15 interferon gamma Homo sapiens 54-62 31598394-8 2019 ANA also synergized with the cell death-inducing cytokines IFN-alpha, IFN-gamma, TNF-alpha, or TRAIL, which regulated the same set of genes as ANA did, to induce apoptosis of the cancer cells. anagrelide 0-3 interferon gamma Homo sapiens 70-79 31598394-8 2019 ANA also synergized with the cell death-inducing cytokines IFN-alpha, IFN-gamma, TNF-alpha, or TRAIL, which regulated the same set of genes as ANA did, to induce apoptosis of the cancer cells. anagrelide 143-146 interferon gamma Homo sapiens 70-79 31228705-4 2019 Owing to the ROS scavenging ability of quercetin, Qu-FeIIP effectively reduces intracellular ROS and in vivo inflammatory factors (TNF-alpha, IL-6, IFN-gamma) levels. Quercetin 39-48 interferon gamma Homo sapiens 148-157 31034990-8 2019 Results also disclosed IFN-gamma as a proinflammatory cytokine that cooperates with LPS to induce the expression of adhesion molecules, prostaglandin E2 and interleukins. Dinoprostone 136-152 interferon gamma Homo sapiens 23-32 31228705-4 2019 Owing to the ROS scavenging ability of quercetin, Qu-FeIIP effectively reduces intracellular ROS and in vivo inflammatory factors (TNF-alpha, IL-6, IFN-gamma) levels. qu-feiip 50-58 interferon gamma Homo sapiens 148-157 31202985-6 2019 The effect of DGLA on interferon-gamma signaling was mediated via inhibition of signal transducer and activator of transcription-1 phosphorylation on serine 727. 8,11,14-Eicosatrienoic Acid 14-18 interferon gamma Homo sapiens 22-38 31202985-6 2019 The effect of DGLA on interferon-gamma signaling was mediated via inhibition of signal transducer and activator of transcription-1 phosphorylation on serine 727. Serine 150-156 interferon gamma Homo sapiens 22-38 30737788-12 2019 Intracellular TNF-alpha and IFN-gamma production decreased in presence of idelalisib. idelalisib 74-84 interferon gamma Homo sapiens 28-37 31221438-6 2019 Dexamethasone-treated TRIMEL/DCs inhibited allogeneic CD4+ T cell proliferation and cytokine release (IFNgamma, TNF-alpha and IL-17). Dexamethasone 0-13 interferon gamma Homo sapiens 102-110 31221438-6 2019 Dexamethasone-treated TRIMEL/DCs inhibited allogeneic CD4+ T cell proliferation and cytokine release (IFNgamma, TNF-alpha and IL-17). polyimide resin 22-28 interferon gamma Homo sapiens 102-110 31533896-5 2019 Adding IFN-gamma in the presence of Ibtx had no effect on IK. iberiotoxin 36-40 interferon gamma Homo sapiens 7-16 30868592-8 2019 RESULTS: Kgp12, 17, and 18 peptides induced lower production of IFN-gamma. Peptides 27-35 interferon gamma Homo sapiens 64-73 30972766-8 2019 Inhibition of the MAPK pathway, using EGFR inhibitors cetuximab and erlotinib or the MEK 1 and 2 inhibitor selumetinib, prevented EGF- and IFNgamma-induced CD274 mRNA and PD-L1 protein and membrane upregulation, but had no effect on IFNgamma-induced MHC-I upregulation. Erlotinib Hydrochloride 68-77 interferon gamma Homo sapiens 139-147 30972766-8 2019 Inhibition of the MAPK pathway, using EGFR inhibitors cetuximab and erlotinib or the MEK 1 and 2 inhibitor selumetinib, prevented EGF- and IFNgamma-induced CD274 mRNA and PD-L1 protein and membrane upregulation, but had no effect on IFNgamma-induced MHC-I upregulation. AZD 6244 107-118 interferon gamma Homo sapiens 139-147 31173374-6 2019 We observed that while exposure to L braziliensis induced an inflammatory profile, as measured by the expression of granzyme A, IFN-gamma and IL-17, as well as a higher IFN/IL-10 ratio, exposure to L infantum led to a regulatory profile, as measured by lower IFN/IL-10 ratio and higher expression of CTLA-4. braziliensis 37-49 interferon gamma Homo sapiens 128-137 31461509-0 2019 Host cell depletion of tryptophan by IFNgamma-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii. Tryptophan 23-33 interferon gamma Homo sapiens 37-45 30325468-8 2019 Feeding PA supplemented diets downregulated the expression of CD40LG (P < 0.001), IFNG, and IL6 (P < 0.05). Protactinium 8-10 interferon gamma Homo sapiens 82-86 31461509-9 2019 Cells deficient in IDO1 function were more permissive for C. burnetii replication when treated with IFNgamma, and supplementing IFNgamma-treated cells with tryptophan enhanced intracellular replication. Tryptophan 156-166 interferon gamma Homo sapiens 128-136 31461509-11 2019 Using differentiated THP1 macrophage-like cells it was determined that IFNgamma-activation resulted in IDO1 production, and that supplementation of IFNgamma-activated THP1 cells with tryptophan enhanced C. burnetii replication. Tryptophan 183-193 interferon gamma Homo sapiens 148-156 31636925-3 2019 First, a ferrocene (Fc)-labeled structure-switching signaling aptamer with a hairpin structure targeting IFN-gamma was immobilized on magnetic nanobeads by the strongest noncovalent interactions between streptavidin and biotin. ferrocene 9-18 interferon gamma Homo sapiens 105-114 31636925-3 2019 First, a ferrocene (Fc)-labeled structure-switching signaling aptamer with a hairpin structure targeting IFN-gamma was immobilized on magnetic nanobeads by the strongest noncovalent interactions between streptavidin and biotin. ferrocene 20-22 interferon gamma Homo sapiens 105-114 31636925-5 2019 The binding of IFN-gamma could trigger the hairpin structure of the aptamer to unfold, pushing Fc redox molecules away from the sensing interface and consequently switching off the electrochemical signal. ferrocene 95-97 interferon gamma Homo sapiens 15-24 31636925-3 2019 First, a ferrocene (Fc)-labeled structure-switching signaling aptamer with a hairpin structure targeting IFN-gamma was immobilized on magnetic nanobeads by the strongest noncovalent interactions between streptavidin and biotin. Biotin 220-226 interferon gamma Homo sapiens 105-114 31636925-6 2019 The change in the redox current of Fc was quantitatively related to the concentration of IFN-gamma in a linear range of 10-500 pg mL-1 and with the lowest detection limit of 6 pg mL-1. ferrocene 35-37 interferon gamma Homo sapiens 89-98 31399282-4 2019 Here, genetic, genomic, metabolic, and immunological analyses revealed that creatine reprogrammed macrophage polarization by suppressing M(interferon-gamma [IFN-gamma]) yet promoting M(interleukin-4 [IL-4]) effector functions. Creatine 76-84 interferon gamma Homo sapiens 157-166 31438528-4 2019 ST-I4C attenuated the MGO-induced expression of inflammatory-related genes, such as tumor necrosis factor (TNF)-alpha and IFN-gamma by activating nuclear factor-kappa B (NF-kappaB) without toxicity in HepG2 cells. Pyruvaldehyde 22-25 interferon gamma Homo sapiens 122-131 30606080-14 2019 Mitogen-activated protein kinase kinase 1 and 2, JNK, and NFkappaB signaling mediate IL-1beta-, TNF-alpha-, and IFN-gamma-induced CX3CL1 production by FTDCs. ftdcs 151-156 interferon gamma Homo sapiens 112-121 31399282-5 2019 Mechanistically, creatine inhibited the induction of immune effector molecules, including iNOS, by suppressing IFN-gamma-JAK-STAT1 transcription-factor signaling while supporting IL-4-STAT6-activated arginase 1 expression by promoting chromatin remodeling. Creatine 17-25 interferon gamma Homo sapiens 111-120 31434199-12 2019 However, the presence of IL-2 and IFN-gamma indicates additional involvement of T cell-mediated response in patients with AL, although this could not be detected by patch testing. Aluminum 122-124 interferon gamma Homo sapiens 34-43 31399282-7 2019 These results uncover a previously uncharacterized role for creatine in macrophage polarization by modulating cellular responses to cytokines such as IFN-gamma and IL-4. Creatine 60-68 interferon gamma Homo sapiens 150-159 31226416-8 2019 GOS pre-treatment significantly attenuated LPS-induced cell injury, as evidenced by the increase of cell viability, the decrease of apoptosis, as well as the suppressed release of TNF-alpha, IFN-gamma and IL-1beta. D-Glucitol-1,6-bisphosphate 0-3 interferon gamma Homo sapiens 191-200 31522446-12 2019 Followingstimulation, expressions of CD107a and intracellular IFN-gamma were elevated in tumor CMV positive patients while the TNF-alpha secretion was decreased. MEC protocol 1 95-98 interferon gamma Homo sapiens 62-71 31475011-4 2019 Our results showed that zebularine restrained the expression of inflammatory cytokines IFN-gamma and IL-17 in both human and murine CD4+ T cells in vitro. pyrimidin-2-one beta-ribofuranoside 24-34 interferon gamma Homo sapiens 87-96 31413142-11 2019 Re-resection in five of five patients with suspected recurrence after Ad-RTS-hIL-12 revealed mostly pseudoprogression with increased tumor-infiltrating lymphocytes producing IFN-gamma and programmed cell death protein 1 (PD-1). hil-12 77-83 interferon gamma Homo sapiens 174-183 31217278-9 2019 Therefore, PS exposure mediated by RIPK3-activated MLKL oligomers was induced by a treatment with IFN-gamma for a significant interval of time before the induction of necroptosis by membrane rupture. Phosphatidylserines 11-13 interferon gamma Homo sapiens 98-107 31406210-4 2019 Stimulation of myeloid blasts" maturation by all-trans retinoic acid (ATRA) or 1alpha,25-dihydroxyvitamin D3 (vitamin D) increased the CD11b+ fraction that expressed PD-1 ligands in response to IFN-gamma. Tretinoin 45-68 interferon gamma Homo sapiens 194-203 31406210-4 2019 Stimulation of myeloid blasts" maturation by all-trans retinoic acid (ATRA) or 1alpha,25-dihydroxyvitamin D3 (vitamin D) increased the CD11b+ fraction that expressed PD-1 ligands in response to IFN-gamma. Tretinoin 70-74 interferon gamma Homo sapiens 194-203 31406210-4 2019 Stimulation of myeloid blasts" maturation by all-trans retinoic acid (ATRA) or 1alpha,25-dihydroxyvitamin D3 (vitamin D) increased the CD11b+ fraction that expressed PD-1 ligands in response to IFN-gamma. Calcitriol 79-108 interferon gamma Homo sapiens 194-203 31406210-4 2019 Stimulation of myeloid blasts" maturation by all-trans retinoic acid (ATRA) or 1alpha,25-dihydroxyvitamin D3 (vitamin D) increased the CD11b+ fraction that expressed PD-1 ligands in response to IFN-gamma. Vitamin D 98-107 interferon gamma Homo sapiens 194-203 31217278-4 2019 PS exposure and necroptosis were significant after 6- and 24-h treatments with IFN-gamma, respectively. Phosphatidylserines 0-2 interferon gamma Homo sapiens 79-88 31447768-9 2019 The protective effects by alphaCD147 treatment were associated with deceased lung inflammatory cell infiltration by reducing IL-17A expression in lung gammadelta T cells and attenuated bacterial load by enhancing IFN-gamma expression in the lung NK1.1+ cells and CD4+ T cells. alphacd147 26-36 interferon gamma Homo sapiens 213-222 31217278-7 2019 In human colorectal adenocarcinoma-derived HT29 cells, PS exposure and necroptosis were similarly induced by treatment with IFN-gamma in the presence of Smac mimetics and z-VAD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 171-180 interferon gamma Homo sapiens 124-133 31391334-0 2019 Augmentation of IFN-gamma+ CD8+ T cell responses correlates with survival of HCC patients on sorafenib therapy. Sorafenib 93-102 interferon gamma Homo sapiens 16-25 30922782-7 2019 Intracellular domain analysis of CRFB17 and CRFB13 demonstrated that the Y386 tyrosine residue of CRFB13 is required for the activation of the IFN-gamma-mediated biologic response, and the Y324 and Y370 residues in CRFB17 are required to activate IFN-gammarel signalling. Tyrosine 78-86 interferon gamma Homo sapiens 143-152 31141391-8 2019 Moreover, we observed AGS-induced suppression of chymotrypsin- and trypsin-like proteasome activities necessary for peptide processing by proteasome as well as a decline in IFNgamma-stimulated immunoproteasome (IPR) function and expression of PA28 activator and immunoproteasome subunits LMP7 and LMP2. ags 22-25 interferon gamma Homo sapiens 173-181 31141391-10 2019 The attenuation of IPR and PLC activation was attributed to AGS-triggered impairment of IFNgamma signaling in HepG2.2.15 cells. ags 60-63 interferon gamma Homo sapiens 88-96 31141391-11 2019 Collectively, all these downstream events reduced the display of HBV peptide-MHC class I complexes on the hepatocyte surface, which may suppress CTL activation and the recognition of CTL epitopes on HBV-expressing hepatocytes by immune cells, thereby leading to persistence of liver inflammation.NEW & NOTEWORTHY Our study shows that in HBV-expressing HepG2.2.15 cells, acetaldehyde alters HBV peptide processing by suppressing chymotrypsin- and trypsin-like proteasome activities and decreases IFNgamma-stimulated immunoproteasome function and expression of PA28 activator and immunoproteasome subunits. Adenosine Monophosphate 301-304 interferon gamma Homo sapiens 499-507 31141391-11 2019 Collectively, all these downstream events reduced the display of HBV peptide-MHC class I complexes on the hepatocyte surface, which may suppress CTL activation and the recognition of CTL epitopes on HBV-expressing hepatocytes by immune cells, thereby leading to persistence of liver inflammation.NEW & NOTEWORTHY Our study shows that in HBV-expressing HepG2.2.15 cells, acetaldehyde alters HBV peptide processing by suppressing chymotrypsin- and trypsin-like proteasome activities and decreases IFNgamma-stimulated immunoproteasome function and expression of PA28 activator and immunoproteasome subunits. Acetaldehyde 374-386 interferon gamma Homo sapiens 499-507 31233057-0 2019 Chitosan/poly(gamma-glutamic acid) nanoparticles incorporating IFN-gamma for immune response modulation in the context of colorectal cancer. Chitosan 0-8 interferon gamma Homo sapiens 63-72 31233057-0 2019 Chitosan/poly(gamma-glutamic acid) nanoparticles incorporating IFN-gamma for immune response modulation in the context of colorectal cancer. poly(gamma-glutamic acid) 9-34 interferon gamma Homo sapiens 63-72 31233057-5 2019 Here, we evaluated the potential of Ch/gamma-PGA NPs as vehicles for IFN-gamma and their ability to modulate immune cells" phenotype. poly(gamma-glutamic acid) 39-48 interferon gamma Homo sapiens 69-78 31233057-6 2019 In this study, Ch/IFN-gamma/gamma-PGA nanoparticles (IFN-gamma-NPs) prepared by a co-acervation method, presenting a size of approximately 180 nm and a low polydispersity index, were tested for their immunomodulatory activity. poly(gamma-glutamic acid) 28-37 interferon gamma Homo sapiens 53-62 31233057-12 2019 This work bridges the previously reported immunostimulatory capacity of Ch/gamma-PGA NPs with their potential as carriers for immunomodulatory molecules, like IFN-gamma, opening new avenues for their use in clinical settings. poly(gamma-glutamic acid) 75-84 interferon gamma Homo sapiens 159-168 30919933-8 2019 Moreover, fructose exposed DCs also induced interferon (IFN)-gamma secretion from T cells. Fructose 10-18 interferon gamma Homo sapiens 44-66 31005727-8 2019 In presence of OSCC an increased concentration of IL-8(p = 0.004), IL-6(p = 0.005), VEGF(p = 0.014), MIP-1ss(p = 0.033), IP-10(p = 0.047), IL-1beta(p = 0.049) was observed; conversely the concentration of IFN-gamma(p = 0.036) and IL-5(P = 0.048) decreased. oscc 15-19 interferon gamma Homo sapiens 205-214 31268768-0 2019 End TB Strategy: Time to Move on From the Skin Test to the Interferon-gamma Release Assays. Terbium 4-6 interferon gamma Homo sapiens 59-75 30657173-7 2019 The protein production of the proinflammatory cytokines TNF-alpha, interferon gamma, IL-1beta, IL-6 and IL-17A was significantly inhibited by adalimumab, infliximab, ustekinumab, prednisolone (all P < 0 001) and rituximab (P = 0 0071), but not by secukinumab (P = 0 0663). Prednisolone 179-191 interferon gamma Homo sapiens 67-83 31071396-6 2019 In addition, the levels of NO, iNOS, TNF-alpha, IFN-gamma, IL-1beta and IL-12 were enhanced in the peritoneal macrophages by stimulation with cationic polymer modified AHPP nanoparticles. Polymers 151-158 interferon gamma Homo sapiens 48-57 31069604-6 2019 DEX (1.000 nM) treatment in PBMC of SSc patients stimulated with anti-CD3 and anti-CD28 promoted a significant reduction in IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-gamma, TNF, IL-1beta (p < 0.001 for all), and IL-17F (p = 0.023) cytokines levels. Dexamethasone 0-3 interferon gamma Homo sapiens 157-166 31069604-8 2019 In PBMC from healthy volunteers, we observed that DEX treatment significantly reduced IL-4, IFN-gamma (p = 0.003 for both), IL-6, IL-10, IL-17A, and TNF (p = 0.002 for all) cytokines. Dexamethasone 50-53 interferon gamma Homo sapiens 92-101 31071396-6 2019 In addition, the levels of NO, iNOS, TNF-alpha, IFN-gamma, IL-1beta and IL-12 were enhanced in the peritoneal macrophages by stimulation with cationic polymer modified AHPP nanoparticles. ahpp 168-172 interferon gamma Homo sapiens 48-57 30738171-10 2019 GBR 830 induced significant progressive reductions in TH1 (IFN-gamma/CXCL10), TH2 (IL-31/CCL11/CCL17), and TH17/TH22 (IL-23p19/IL-8/S100A12) mRNA expression in lesional skin. gbr 830 0-7 interferon gamma Homo sapiens 59-68 31009295-5 2019 Our results demonstrate that when IL-27 or IFN-gamma is added with polyinosinic-polycytidylic acid [poly(I:C)], type I IFN (IFN-I) expression increases concurrently with cell death. Poly I-C 67-98 interferon gamma Homo sapiens 43-52 31009295-5 2019 Our results demonstrate that when IL-27 or IFN-gamma is added with polyinosinic-polycytidylic acid [poly(I:C)], type I IFN (IFN-I) expression increases concurrently with cell death. Poly I-C 100-109 interferon gamma Homo sapiens 43-52 31006829-7 2019 IFN-gamma significantly inhibited hCM proliferation, and IFN-gamma-induced IDO expression caused cell cycle arrest in G0/G1 through tryptophan depletion. Tryptophan 132-142 interferon gamma Homo sapiens 57-66 31366130-3 2019 IFNgamma and TNFalpha increased basal, adenophostin-A (AdA)-evoked, and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA)-evoked astroglial L-glutamate releases. adenophostin A 39-53 interferon gamma Homo sapiens 0-8 31173242-8 2019 Both IFNgamma-induced upregulation of PD-L1 and downregulation of NKG2D ligands were blocked by the JAK-STAT inhibitor tofacitinib. tofacitinib 119-130 interferon gamma Homo sapiens 5-13 31417556-8 2019 We conclude that, as measured by an IFN-gamma ELISPOT assay, a single dose of TAK-003 generates potent T cell-mediated immunity which is durable in magnitude and breadth through 4 months post-vaccination. tak-003 78-85 interferon gamma Homo sapiens 36-45 31602908-7 2019 Triptolide stimulated immune response pathways by the main molecules of IFNgamma,JAK2,NOD1,PTGS2,RORC. triptolide 0-10 interferon gamma Homo sapiens 72-80 31602908-8 2019 IFNgamma is the focus nodes of triptolide and AIDS,and regulates genes of AIDS directly or indirectly. triptolide 31-41 interferon gamma Homo sapiens 0-8 31602908-9 2019 Triptolide may against AIDS by regulating molecules IFNgamma in immune response pathways. triptolide 0-10 interferon gamma Homo sapiens 52-60 31366130-3 2019 IFNgamma and TNFalpha increased basal, adenophostin-A (AdA)-evoked, and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA)-evoked astroglial L-glutamate releases. adenophostin A 55-58 interferon gamma Homo sapiens 0-8 31366130-3 2019 IFNgamma and TNFalpha increased basal, adenophostin-A (AdA)-evoked, and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA)-evoked astroglial L-glutamate releases. 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid 72-130 interferon gamma Homo sapiens 0-8 31366130-3 2019 IFNgamma and TNFalpha increased basal, adenophostin-A (AdA)-evoked, and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA)-evoked astroglial L-glutamate releases. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 132-136 interferon gamma Homo sapiens 0-8 31366130-3 2019 IFNgamma and TNFalpha increased basal, adenophostin-A (AdA)-evoked, and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA)-evoked astroglial L-glutamate releases. Glutamic Acid 156-167 interferon gamma Homo sapiens 0-8 31366130-9 2019 Especifically, chronic administration of CBZ and CGS21680 prevented the reduction and elevation of A2AR expression by respective IFNgamma and TNFalpha. Carbamazepine 41-44 interferon gamma Homo sapiens 129-137 31366130-9 2019 Especifically, chronic administration of CBZ and CGS21680 prevented the reduction and elevation of A2AR expression by respective IFNgamma and TNFalpha. 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 49-57 interferon gamma Homo sapiens 129-137 31396228-9 2019 Here, a strong inhibition of T cell proliferation and reduction of pro-inflammatory cytokines (IFNgamma, TNFalpha, TNFbeta, IL-17A, IL-2) were observable after pre-stimulation of hAACs with IFNgamma. haacs 179-184 interferon gamma Homo sapiens 95-103 31396228-9 2019 Here, a strong inhibition of T cell proliferation and reduction of pro-inflammatory cytokines (IFNgamma, TNFalpha, TNFbeta, IL-17A, IL-2) were observable after pre-stimulation of hAACs with IFNgamma. haacs 179-184 interferon gamma Homo sapiens 190-198 31379807-7 2019 Treatment with 1,25(OH)2D3 inhibited pro-inflammatory cytokines such as IL-17A, IL-17F, IL-22 and IFNgamma in memory CCR6+ Th cells from both healthy controls and RA patients. Calcitriol 15-26 interferon gamma Homo sapiens 98-106 31330988-5 2019 The enzyme-linked immunosorbent assay (ELISA) and quantitative real time polymerase chain reaction (qRT-PCR) results demonstrated stronger inhibitory effects of pitavastatin on the cytokine production of T cells activated by phorbol 12-myristate 13-acetate (PMA) plus ionomycin, including interleukin (IL)-2, interferon (IFN)-gamma, IL-6, and tumor necrosis factor alpha (TNF-alpha). pitavastatin 161-173 interferon gamma Homo sapiens 309-331 31221816-7 2019 DOX and DTX could delay tumor growth, activate the NF-kappaB pathway, and promote IFN-gamma secretion in the PDTX models. Doxorubicin 0-3 interferon gamma Homo sapiens 82-91 31310587-8 2019 These results suggest an IFNgamma-JAK-STAT-TET signaling pathway that mediates tumor response to anti-PD-L1/PD-1 therapy and is frequently disrupted in solid tumors. tetramethylenedisulfotetramine 43-46 interferon gamma Homo sapiens 25-33 30940655-7 2019 Furthermore, our results showed that regorafenib, in vitro and in vivo, strongly promoted the antitumor efficacy when combined with IFNgamma or ICB. regorafenib 37-48 interferon gamma Homo sapiens 132-140 30940655-8 2019 By targeting the RET-Src axis, regorafenib potently inhibited JAK1/2-STAT1 and MAPK signaling and subsequently attenuated the IFNgamma-induced PD-L1 and IDO1 expression without affecting MHC-I expression much. regorafenib 31-42 interferon gamma Homo sapiens 126-134 30940655-10 2019 CONCLUSIONS: Our data unveiled a new mechanism of alleviating IFNgamma-induced PD-L1 and IDO1 expression and provided a rationale to explore a novel combination of ICB with regorafenib clinically, especially in melanoma with RET/Src axis activation. indole-2-carboxylic acid 164-167 interferon gamma Homo sapiens 62-70 30940655-10 2019 CONCLUSIONS: Our data unveiled a new mechanism of alleviating IFNgamma-induced PD-L1 and IDO1 expression and provided a rationale to explore a novel combination of ICB with regorafenib clinically, especially in melanoma with RET/Src axis activation. regorafenib 173-184 interferon gamma Homo sapiens 62-70 31187614-2 2019 Here, we report a metallic Fe (iron)-Au (gold) BNW-based platform for capturing CD8 T cells and the interferon-gamma (gamma) they secrete, both of which play key roles in controlling infectious diseases such as tuberculosis, at the single-cell level. Iron 27-29 interferon gamma Homo sapiens 100-116 31187614-2 2019 Here, we report a metallic Fe (iron)-Au (gold) BNW-based platform for capturing CD8 T cells and the interferon-gamma (gamma) they secrete, both of which play key roles in controlling infectious diseases such as tuberculosis, at the single-cell level. Iron 31-36 interferon gamma Homo sapiens 100-116 31187614-2 2019 Here, we report a metallic Fe (iron)-Au (gold) BNW-based platform for capturing CD8 T cells and the interferon-gamma (gamma) they secrete, both of which play key roles in controlling infectious diseases such as tuberculosis, at the single-cell level. Gold 37-39 interferon gamma Homo sapiens 100-116 31354696-9 2019 The velocity of pSTAT1 dephosphorylation after treatment of IFNgamma stimulated CD14+ monocytes with the Janus Kinase (JAK)-inhibitor ruxolitinib was significantly faster in patient cells. ruxolitinib 134-145 interferon gamma Homo sapiens 60-68 31221816-7 2019 DOX and DTX could delay tumor growth, activate the NF-kappaB pathway, and promote IFN-gamma secretion in the PDTX models. Docetaxel 8-11 interferon gamma Homo sapiens 82-91 31334125-11 2019 Treatment with diclofenac reduced lactate and amino acid levels in AK, especially in responding lesions, and induced an infiltration of dermal CD8+ T cells accompanied by high IFN-gamma mRNA expression, suggesting improved T cell function. Diclofenac 15-25 interferon gamma Homo sapiens 176-185 30593845-9 2019 Addition of miR-26b-5p contributed to secretion of tumor necrosis factor alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-6 (IL-6) and IL-2 in CD4+ and CD8+ cells. mir-26b-5p 12-22 interferon gamma Homo sapiens 92-108 30593845-9 2019 Addition of miR-26b-5p contributed to secretion of tumor necrosis factor alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-6 (IL-6) and IL-2 in CD4+ and CD8+ cells. mir-26b-5p 12-22 interferon gamma Homo sapiens 110-119 30981891-2 2019 QuantiFERON-TB-Plus (QFT-P), an LTBI diagnostic test, measures IFN-gamma after M. tuberculosis-stimulation in TB1 and TB2 tubes in which a "CD4" or a "CD4 and CD8" response is respectively elicited. quantiferon-tb-plus 0-19 interferon gamma Homo sapiens 63-72 31059842-10 2019 Fenofibrate, in presence of IFNgamma plus TNFalpha, dose-dependently inhibited both CXCL10 and CXCL8 release. Fenofibrate 0-11 interferon gamma Homo sapiens 28-36 31281457-8 2019 In addition, pathway analysis and comparison with Bay11-7082 indicated that these effects are due to the inhibition of nuclear factor (NF)-kappaB in TNF-alpha/IFN-gamma-induced HaCaT cells. 3-(4-methylphenylsulfonyl)-2-propenenitrile 50-60 interferon gamma Homo sapiens 159-168 30121625-10 2019 Acetaldehyde also attenuated interferon-gamma production in phytohaemagglutinin-stimulated human peripheral lymphocytes. Acetaldehyde 0-12 interferon gamma Homo sapiens 29-45 30707971-9 2019 Surprisingly, A598F and other V617F-inhibiting mutations (F595A, E596R, and F537A) significantly impaired IFN-gamma signaling. a598f 14-19 interferon gamma Homo sapiens 106-115 31028753-6 2019 With respect to cytokine inductions, APCs treated with either Sal-HA or Sal-M2e induced significantly (p < .05) higher mRNA transcription levels of proinflammatory (IL-1beta, IL-6, IL-12 and IL-23), Th1 (IFN-gamma), Th17 (IL-17 and IL-21) and Th2 (IL-10 and TGF-beta) cytokines in T cells compared to Sal-NA or Salmonella alone treated APCs. sal-ha 62-68 interferon gamma Homo sapiens 207-216 30981891-2 2019 QuantiFERON-TB-Plus (QFT-P), an LTBI diagnostic test, measures IFN-gamma after M. tuberculosis-stimulation in TB1 and TB2 tubes in which a "CD4" or a "CD4 and CD8" response is respectively elicited. qft-p 21-26 interferon gamma Homo sapiens 63-72 31028753-6 2019 With respect to cytokine inductions, APCs treated with either Sal-HA or Sal-M2e induced significantly (p < .05) higher mRNA transcription levels of proinflammatory (IL-1beta, IL-6, IL-12 and IL-23), Th1 (IFN-gamma), Th17 (IL-17 and IL-21) and Th2 (IL-10 and TGF-beta) cytokines in T cells compared to Sal-NA or Salmonella alone treated APCs. sal-m2e 72-79 interferon gamma Homo sapiens 207-216 30981891-8 2019 Applying a logistic regression analysis, we found that IMID-LTBI patients had a higher probability (TB1 stimulation OR 3.32; TB2 stimulation OR 4.33) to have IFNgamma results <=0.7 IU/mL compared to NON-IMID-LTBI-subjects. benzyloxyaspartate 100-103 interferon gamma Homo sapiens 158-166 31036692-8 2019 Our findings suggest that miltefosine-induced activation of Th1 cytokines, particularly represented by increased gamma interferon (IFN-gamma) and interleukin 12 (IL-12), is essential to prevail over the Leishmania-driven Th2 response. miltefosine 26-37 interferon gamma Homo sapiens 113-140 31150805-6 2019 in vitro assay, we found that trichloroethylene metabolites trichloroacetaldehyde (TCAH), not trichloroacetic acid (TCA) or Trichloroethanol (TCOH) could activate the naive CD4+ T cells characterized by a rise in intracellular calcium, down-regulated CD62 L and subsequently trigger the secretion of IL-2, IFN-gamma and TNF-alpha. Trichloroethylene 30-47 interferon gamma Homo sapiens 306-315 31150805-6 2019 in vitro assay, we found that trichloroethylene metabolites trichloroacetaldehyde (TCAH), not trichloroacetic acid (TCA) or Trichloroethanol (TCOH) could activate the naive CD4+ T cells characterized by a rise in intracellular calcium, down-regulated CD62 L and subsequently trigger the secretion of IL-2, IFN-gamma and TNF-alpha. trichloroacetaldehyde 60-81 interferon gamma Homo sapiens 306-315 31150805-6 2019 in vitro assay, we found that trichloroethylene metabolites trichloroacetaldehyde (TCAH), not trichloroacetic acid (TCA) or Trichloroethanol (TCOH) could activate the naive CD4+ T cells characterized by a rise in intracellular calcium, down-regulated CD62 L and subsequently trigger the secretion of IL-2, IFN-gamma and TNF-alpha. trichloroacetaldehyde 83-87 interferon gamma Homo sapiens 306-315 31150805-6 2019 in vitro assay, we found that trichloroethylene metabolites trichloroacetaldehyde (TCAH), not trichloroacetic acid (TCA) or Trichloroethanol (TCOH) could activate the naive CD4+ T cells characterized by a rise in intracellular calcium, down-regulated CD62 L and subsequently trigger the secretion of IL-2, IFN-gamma and TNF-alpha. Calcium 227-234 interferon gamma Homo sapiens 306-315 31219804-5 2019 Indeed, following immunization with an attenuated whole sporozoite malaria vaccine in humans, significantly higher numbers of IFN-gamma producing memory CD8 T-cells comprised of antigen specific and bystander responses were detected by increasing the duration of Ag-stimulation prior to addition of BFA. Brefeldin A 299-302 interferon gamma Homo sapiens 126-135 31160675-5 2019 The results indicated that poly I:C alone and in combination with Pam3CSK4 alleviated vaccine-induced immunosuppression, as evidenced by greater weight gain, increased overall antibody responses to both sheep erythrocytes and live infectious bronchitis virus vaccine, upregulated IFN-gamma transcripts and nitric oxide production by PBMCs (P < 0.05), and lower bursal lesion score in the experimental birds. Poly I-C 27-35 interferon gamma Homo sapiens 280-289 33405584-2 2019 In this study, multilayers of heparin and collagen (HEP/COL) were used as a bioactive surface coating to enhance human MSC (hMSC) response to soluble interferon-gamma (IFN-gamma). Heparin 30-37 interferon gamma Homo sapiens 150-166 33405584-2 2019 In this study, multilayers of heparin and collagen (HEP/COL) were used as a bioactive surface coating to enhance human MSC (hMSC) response to soluble interferon-gamma (IFN-gamma). Heparin 30-37 interferon gamma Homo sapiens 168-177 31249571-5 2019 Mechanistically, our data showed that F. nucleatum aggravated dextran sodium sulfate (DSS)-induced colitis in the production of Th1-related cytokines IFN-gamma through the AKT2 signaling pathway in vitro and in vivo. dextran sodium sulfate 62-84 interferon gamma Homo sapiens 150-159 31249571-5 2019 Mechanistically, our data showed that F. nucleatum aggravated dextran sodium sulfate (DSS)-induced colitis in the production of Th1-related cytokines IFN-gamma through the AKT2 signaling pathway in vitro and in vivo. dss 86-89 interferon gamma Homo sapiens 150-159 30753544-6 2019 At a functional level, metformin lowered ex vivo production of tumor necrosis factor alpha, interferon gamma, and interleukin 1beta but increased phagocytosis activity and reactive oxygen species production. Metformin 23-32 interferon gamma Homo sapiens 92-108 30942429-9 2019 IFN-gamma expression in Raw 264.7 macrophages was suppressed by an NF-kappaB inhibitor (Bay117082) but enhanced by sRAGE, with or without I/R treatment. 3-(4-methylphenylsulfonyl)-2-propenenitrile 88-97 interferon gamma Homo sapiens 0-9 31053913-4 2019 In this study, we found that rhArg attenuated macrophage functions, including inhibiting macrophage cell proliferation, nitric oxide (NO) and reactive oxygen species (ROS) production, cytokine secretion, MHC-II surface expression, and phagocytosis, thereby inducing immunosuppression in lipopolysaccharides (LPS)/interferon-gamma (IFN-gamma)-activated macrophages. rharg 29-34 interferon gamma Homo sapiens 313-329 31053913-4 2019 In this study, we found that rhArg attenuated macrophage functions, including inhibiting macrophage cell proliferation, nitric oxide (NO) and reactive oxygen species (ROS) production, cytokine secretion, MHC-II surface expression, and phagocytosis, thereby inducing immunosuppression in lipopolysaccharides (LPS)/interferon-gamma (IFN-gamma)-activated macrophages. rharg 29-34 interferon gamma Homo sapiens 331-340 31092034-11 2019 The combination of IFN-gamma and TNF-alpha appeared to augment cisplatin cytotoxicity to cochlear sensory cells ex vivo. Cisplatin 63-72 interferon gamma Homo sapiens 19-28 31078066-6 2019 It has been revealed that pro-inflammatory cytokines such as IFN-gamma, TNF-alpha, TGF-beta, IL-17A, IL-27, IL-33 and thymic stromal lymphopoietin (TSLP) may contribute to steroid resistance in severe asthma and COPD. Steroids 172-179 interferon gamma Homo sapiens 61-70 30957421-6 2019 RESULTS: In the tonsils of patients with IgAN, hyperimmune response to the unmethylated deoxycytidyl-deoxyguanosine oligodeoxynucleotides (CpG-ODN) take place, resulting in hyperproduction of interferon-gamma. deoxycytidyl-deoxyguanosine oligodeoxynucleotides 88-137 interferon gamma Homo sapiens 192-208 30957421-6 2019 RESULTS: In the tonsils of patients with IgAN, hyperimmune response to the unmethylated deoxycytidyl-deoxyguanosine oligodeoxynucleotides (CpG-ODN) take place, resulting in hyperproduction of interferon-gamma. CPG-oligonucleotide 139-146 interferon gamma Homo sapiens 192-208 30779419-7 2019 CD56bright NK cells obtained from SAA patients produced increased IL-10 and decreased IFN-gamma in vitro compared with cells obtained from HC, while TNF-alpha and IL-13 productions were not different between two groups. saa 34-37 interferon gamma Homo sapiens 86-95 31013450-4 2019 Lovastatin treatment resulted in increased levels of IL-6, IL-12p40, and IFN-gamma mRNA in both PBMCs and monocytes following LPS stimulation compared with control cells. Lovastatin 0-10 interferon gamma Homo sapiens 73-82 30317606-8 2019 In addition, physalin D is protective in M2 macrophages to maintain the M2 phenotype in the presence of IFN-gamma. physalin D 13-23 interferon gamma Homo sapiens 104-113 31013450-5 2019 An IL-12 neutralizing antibody blocked the increased levels of IFN-gamma mRNA following lovastatin treatment in PBMCs indicating that this effect is dependent on IL-12. Lovastatin 88-98 interferon gamma Homo sapiens 63-72 30939587-0 2019 Suppressive Effect of Everolimus on IL-2, IL-10, IL-21, and IFNgamma Levels: Implications for the Successful Minimization of Calcineurin Inhibitor Use in Transplantation. Everolimus 22-32 interferon gamma Homo sapiens 60-68 30872332-6 2019 Overexpression of miR-148a-3p repressed IFNgamma-induced PD-L1 expression on tumor cells and consequently diminished T-cell apoptosis in a coculture model of IL2-activated T cells and IFNgamma-treated tumor cells. mir-148a-3p 18-29 interferon gamma Homo sapiens 40-48 30872332-6 2019 Overexpression of miR-148a-3p repressed IFNgamma-induced PD-L1 expression on tumor cells and consequently diminished T-cell apoptosis in a coculture model of IL2-activated T cells and IFNgamma-treated tumor cells. mir-148a-3p 18-29 interferon gamma Homo sapiens 184-192 31275997-4 2019 In the presence of patient serum, IFN-gamma-induced type 1 macrophage (M1) differentiation was inhibited in PMA-stimulated human monocytic THP-1 cells. Tetradecanoylphorbol Acetate 108-111 interferon gamma Homo sapiens 34-43 31138333-8 2019 Functionally, in vitro generated TAM inhibited the proliferation of T cells (47% decrease from M1-like macrophages) and the production of IFN-gamma by natural killer cells was inhibited (44%) when co-cultured with TAM. tam 33-36 interferon gamma Homo sapiens 138-147 31138333-8 2019 Functionally, in vitro generated TAM inhibited the proliferation of T cells (47% decrease from M1-like macrophages) and the production of IFN-gamma by natural killer cells was inhibited (44%) when co-cultured with TAM. tam 214-217 interferon gamma Homo sapiens 138-147 30817082-10 2019 In Caco-2 cells, it is shown that hesperidin prevents TNF-alpha/IFN-gamma-induced reduction in TEER and morphological disruption. Hesperidin 34-44 interferon gamma Homo sapiens 64-73 31413905-7 2019 Furthermore, low-dose temozolomide in combination with expanded gammadelta T cells and dinutuximab resulted in increased IFNgamma secretion and increased gammadelta T-cell surface expression of FasL and CD107a. Temozolomide 22-34 interferon gamma Homo sapiens 121-129 31100910-10 2019 The level of interferon gamma (IFNgamma) was elevated (p < 0.05) in the infected group at 3 dpi and 7 dpi as compared with the control group, while its level was decreased (p < 0.05) by supplemental 10 mg/kg SI at 3 dpi. 3-aminodiphenyleneiodium 95-98 interferon gamma Homo sapiens 13-40 31125352-8 2019 In the tumors with the highest IC expression and absent TC expression an association with reduced IFNgamma downstream signaling in tumor cells was observed. Technetium 56-58 interferon gamma Homo sapiens 98-106 31126019-5 2019 At meningitis diagnosis, stimulation with cryptococcal capsule component, glucuronoxylomannan (GXM) elicited consistently lower frequencies of CD4+ and CD8+ T cell memory subsets expressing intracellular cytokines (IL-2, IFN-gamma, and IL-17) among subjects who subsequently developed CM-IRIS. glucuronoxylomannan 74-93 interferon gamma Homo sapiens 221-230 31126019-5 2019 At meningitis diagnosis, stimulation with cryptococcal capsule component, glucuronoxylomannan (GXM) elicited consistently lower frequencies of CD4+ and CD8+ T cell memory subsets expressing intracellular cytokines (IL-2, IFN-gamma, and IL-17) among subjects who subsequently developed CM-IRIS. glucuronoxylomannan 95-98 interferon gamma Homo sapiens 221-230 31236419-5 2019 The main findings were the following: (1) NK cells were more sensitive to the S-forms of LPS than the R-forms (LPS lacking O-antigen); (2) LPS triggered a significant increase in IFNgamma production by NK cells in concentrations about 1000 times higher than those that can induce cytokine production by macrophages; (3) the composition and structure of saccharide part of LPS have a strong influence on its observed effects on NK cells; and (4) LPS fully retained the ability to trigger cytokine production in NK cells in serum-free media. Carbohydrates 353-363 interferon gamma Homo sapiens 179-187 30973005-9 2019 Upon receptor binding, the DNA structure bends to induce phthalocyanine dye stacking, resulting in a 55% increase in photoacoustic signal in the presence of 10 muM interferon gamma. phthalocyanine 57-71 interferon gamma Homo sapiens 164-180 31100910-10 2019 The level of interferon gamma (IFNgamma) was elevated (p < 0.05) in the infected group at 3 dpi and 7 dpi as compared with the control group, while its level was decreased (p < 0.05) by supplemental 10 mg/kg SI at 3 dpi. 3-aminodiphenyleneiodium 105-108 interferon gamma Homo sapiens 13-40 31100910-10 2019 The level of interferon gamma (IFNgamma) was elevated (p < 0.05) in the infected group at 3 dpi and 7 dpi as compared with the control group, while its level was decreased (p < 0.05) by supplemental 10 mg/kg SI at 3 dpi. 3-aminodiphenyleneiodium 105-108 interferon gamma Homo sapiens 13-40 31095595-12 2019 Dose response curves were non-monotonic for PAH-DNA adduct exposures and suggested that cytokine secretion of IFNg, IL-1b, IL-2, IL-10 and IL17A followed a complex pattern. Polycyclic Aromatic Hydrocarbons 44-47 interferon gamma Homo sapiens 110-114 31091446-5 2019 Mechanistically, acetate promotes histone acetylation and chromatin accessibility and enhances IFN-gamma gene transcription and cytokine production in an acetyl-CoA synthetase (ACSS)-dependent manner. Acetates 17-24 interferon gamma Homo sapiens 95-104 31091446-6 2019 Ex vivo acetate treatment increases IFN-gamma production by exhausted T cells, whereas reducing ACSS expression in T cells impairs IFN-gamma production by tumor-infiltrating lymphocytes and tumor clearance. Acetates 8-15 interferon gamma Homo sapiens 36-45 31123462-13 2019 Conclusions: These findings indicate that the interaction of TRAF6 with c-Cbl causes lysine 48-linked polyubiquitination for both negative feedback regulation and signaling cross-talk between RANKL and IFN-gamma. Lysine 85-91 interferon gamma Homo sapiens 202-211 30689261-6 2019 RESULTS: We observed the frequency of CD4+ IFN-gamma+ T cells was higher in atopic individuals with SAR than with CSA. Cyclosporine 114-117 interferon gamma Homo sapiens 43-52 30986070-0 2019 alpha-Selective Lysine Ligation and Application in Chemical Synthesis of Interferon Gamma. Lysine 16-22 interferon gamma Homo sapiens 73-89 31217742-9 2019 Finally, we observed that mIFN-DC was significantly more efficient at stimulating autologous CMV-specific CD4+ T cells (0.39 vs. 0.28 %, p<0.05) and CD8+ T cells (0.36 vs. 0.12%, p<0.05) to secrete IFN-gamma compared with mIL-4-DC. mifn-dc 26-33 interferon gamma Homo sapiens 204-213 29313885-0 2019 Interferon gamma treatment increases endocannabinoid and related N-acylethanolamine levels in T84 human colon carcinoma cells. N-acylethanolamines 65-83 interferon gamma Homo sapiens 0-16 29313885-7 2019 KEY RESULTS: IFNgamma treatment for 8 or 24 h increased levels of both endocannabinoids (anandamide and 2-AG) and the related NAEs. anandamide 89-99 interferon gamma Homo sapiens 13-21 29313885-7 2019 KEY RESULTS: IFNgamma treatment for 8 or 24 h increased levels of both endocannabinoids (anandamide and 2-AG) and the related NAEs. glyceryl 2-arachidonate 104-108 interferon gamma Homo sapiens 13-21 29313885-9 2019 IFNgamma treatment reduced the TEER of the cells in a manner that was not prevented by inhibition of either FAAH or NAAA but was partially reversed by apical administration of the NAE palmitoylethanolamide. nae palmitoylethanolamide 180-205 interferon gamma Homo sapiens 0-8 29313885-10 2019 CONCLUSION AND IMPLICATIONS: IFNgamma treatment mobilized endocannabinoid and related NAE levels in T84 cells. N-acylethanolamines 86-89 interferon gamma Homo sapiens 29-37 30817215-4 2019 After inoculation with tcMCMV, lymphocytes from the submandibular gland preferentially express the transcription factor T-cell-specific T-box transcription factor (T-bet), which controls the expression of the hallmark Th1 cytokine, IFN-gamma. tcmcmv 23-29 interferon gamma Homo sapiens 232-241 30851700-10 2019 Serum IL-1beta (p = 0.008) and interferon (IFN)-gamma (p = 0.007) levels tended to be higher in patients with AE-IPF than in those with S-IPF. ae-ipf 110-116 interferon gamma Homo sapiens 31-53 30851700-10 2019 Serum IL-1beta (p = 0.008) and interferon (IFN)-gamma (p = 0.007) levels tended to be higher in patients with AE-IPF than in those with S-IPF. s-ipf 136-141 interferon gamma Homo sapiens 31-53 30851704-10 2019 We also verified the effects of F18-loaded emulsions on activating hematopoietic function, stimulating proliferation of the spleen and natural killer (NK) cells, and promoting the secretion of IFN-gamma and IgG1, although HD-E performed mild toxicity on liver. CAN 508 32-35 interferon gamma Homo sapiens 193-202 31119110-3 2019 IFN-gamma-inducible indole-2,3-dioxygenase 1 (IDO1), which mediates tryptophan degradation, has a major role in anti-T. gondii immune responses in various human cells. Tryptophan 68-78 interferon gamma Homo sapiens 0-9 30765134-10 2019 It was also found that TNF-alpha, GM-CSF and IFN-gamma productions from monocytes/macrophages of thalassemia patients who received iron chelator treatment were significantly higher than those produced from thalassemia patients without iron chelator treatment. Iron 131-135 interferon gamma Homo sapiens 45-54 30765134-10 2019 It was also found that TNF-alpha, GM-CSF and IFN-gamma productions from monocytes/macrophages of thalassemia patients who received iron chelator treatment were significantly higher than those produced from thalassemia patients without iron chelator treatment. Iron 235-239 interferon gamma Homo sapiens 45-54 30846331-9 2019 IFN-gamma-induced Delta42PD1 upregulation was abolished by JAK inhibitors Ruxolitinib and Tasocitinib, PI3K inhibitor LY294002, and AKT inhibitor MK-2206, respectively, but not by STAT1 inhibitor and MAPK signaling pathway inhibitors. ruxolitinib 74-85 interferon gamma Homo sapiens 0-9 30846331-9 2019 IFN-gamma-induced Delta42PD1 upregulation was abolished by JAK inhibitors Ruxolitinib and Tasocitinib, PI3K inhibitor LY294002, and AKT inhibitor MK-2206, respectively, but not by STAT1 inhibitor and MAPK signaling pathway inhibitors. tofacitinib 90-101 interferon gamma Homo sapiens 0-9 30846331-9 2019 IFN-gamma-induced Delta42PD1 upregulation was abolished by JAK inhibitors Ruxolitinib and Tasocitinib, PI3K inhibitor LY294002, and AKT inhibitor MK-2206, respectively, but not by STAT1 inhibitor and MAPK signaling pathway inhibitors. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 118-126 interferon gamma Homo sapiens 0-9 30846331-9 2019 IFN-gamma-induced Delta42PD1 upregulation was abolished by JAK inhibitors Ruxolitinib and Tasocitinib, PI3K inhibitor LY294002, and AKT inhibitor MK-2206, respectively, but not by STAT1 inhibitor and MAPK signaling pathway inhibitors. MK 2206 146-153 interferon gamma Homo sapiens 0-9 30517642-11 2019 Multivariate analyses revealed that the Th17 pathway [IL-17A (P = 0.001), IFN-gamma (P = 0.009), RORgammat (P = 0.003), IL-23R (P = 0.033), IL-21R (P = 0.019)], and Th2 pathway [IL-13 (P = 0.015), GATA3 (P = 0.012)] were associated with TAO. th17 40-44 interferon gamma Homo sapiens 74-83 31083166-3 2019 Intravenous or epidural morphine tended to reduce IFN-gamma expression in CD8 cells. Morphine 24-32 interferon gamma Homo sapiens 50-59 30855208-4 2019 The effect of 8 months sitagliptin, alone or together with 2 months of VitD3, on serum IFN-gamma, IL-4, IL-17, IL-6, IL-21, TGF-beta, and IL-37 levels was determined using enzyme-linked immunosorbent assay. Sitagliptin Phosphate 23-34 interferon gamma Homo sapiens 87-96 30855208-6 2019 Treatment with sitagliptin plus VitD3 reduced the levels of IFN-gamma and IL-17 in both nonnephropathic and nephropathic patients compared with untreated patients. Sitagliptin Phosphate 15-26 interferon gamma Homo sapiens 60-69 30855208-9 2019 These findings indicated that the sitagliptin plus VitD3 was more effective to reduce the increased proinflammatory IFN-gamma and IL-17 cytokines in T2DM patients. Sitagliptin Phosphate 34-45 interferon gamma Homo sapiens 116-125 30580448-8 2019 Using the ovarian granulosa cells (KGN), we demonstrated that DHEA downregulated the expression and secretion of IFN-gamma in dose- and time-dependent manners, which could be restored to some extent by treating with flutamide. Dehydroepiandrosterone 62-66 interferon gamma Homo sapiens 113-122 30580448-8 2019 Using the ovarian granulosa cells (KGN), we demonstrated that DHEA downregulated the expression and secretion of IFN-gamma in dose- and time-dependent manners, which could be restored to some extent by treating with flutamide. Flutamide 216-225 interferon gamma Homo sapiens 113-122 30580448-10 2019 The results also revealed that IFN-gamma promoted the proliferation but inhibited the apoptosis of KGN cells, which was suppressed by DHEA via activating the downstream PI3K/AKT signaling pathway. Dehydroepiandrosterone 134-138 interferon gamma Homo sapiens 31-40 30580448-11 2019 Taken together, these results showed that DHEA inhibited the proliferation and promoted the apoptosis of ovarian granulosa cells through downregulating the expression of IFN-gamma which could be restored by flutamide, and IFN-gamma may serve as a potential inflammatory biomarker for PCOS detection. Dehydroepiandrosterone 42-46 interferon gamma Homo sapiens 170-179 30580448-11 2019 Taken together, these results showed that DHEA inhibited the proliferation and promoted the apoptosis of ovarian granulosa cells through downregulating the expression of IFN-gamma which could be restored by flutamide, and IFN-gamma may serve as a potential inflammatory biomarker for PCOS detection. Dehydroepiandrosterone 42-46 interferon gamma Homo sapiens 222-231 30580448-11 2019 Taken together, these results showed that DHEA inhibited the proliferation and promoted the apoptosis of ovarian granulosa cells through downregulating the expression of IFN-gamma which could be restored by flutamide, and IFN-gamma may serve as a potential inflammatory biomarker for PCOS detection. Flutamide 207-216 interferon gamma Homo sapiens 170-179 31083166-6 2019 Compared with spinal morphine, IV or epidural morphine may more effectively inhibit the expression of various cytokines and thus affect immune response.All 3 routes of morphine injection tended to decrease IL-2 production by CD4 cells, whereas IV or epidural morphine injection showed lower IFN-gamma production by CD8 cells. Morphine 46-54 interferon gamma Homo sapiens 291-300 31083166-6 2019 Compared with spinal morphine, IV or epidural morphine may more effectively inhibit the expression of various cytokines and thus affect immune response.All 3 routes of morphine injection tended to decrease IL-2 production by CD4 cells, whereas IV or epidural morphine injection showed lower IFN-gamma production by CD8 cells. Morphine 46-54 interferon gamma Homo sapiens 291-300 31083166-6 2019 Compared with spinal morphine, IV or epidural morphine may more effectively inhibit the expression of various cytokines and thus affect immune response.All 3 routes of morphine injection tended to decrease IL-2 production by CD4 cells, whereas IV or epidural morphine injection showed lower IFN-gamma production by CD8 cells. Morphine 46-54 interferon gamma Homo sapiens 291-300 31043744-7 2019 Mechanistically, interferon gamma (IFNgamma) released from CD8+ T cells downregulates the expression of SLC3A2 and SLC7A11, two subunits of the glutamate-cystine antiporter system xc-, impairs the uptake of cystine by tumour cells, and as a consequence, promotes tumour cell lipid peroxidation and ferroptosis. Glutamic Acid 144-153 interferon gamma Homo sapiens 17-44 31043744-7 2019 Mechanistically, interferon gamma (IFNgamma) released from CD8+ T cells downregulates the expression of SLC3A2 and SLC7A11, two subunits of the glutamate-cystine antiporter system xc-, impairs the uptake of cystine by tumour cells, and as a consequence, promotes tumour cell lipid peroxidation and ferroptosis. Cystine 154-161 interferon gamma Homo sapiens 17-44 31043744-7 2019 Mechanistically, interferon gamma (IFNgamma) released from CD8+ T cells downregulates the expression of SLC3A2 and SLC7A11, two subunits of the glutamate-cystine antiporter system xc-, impairs the uptake of cystine by tumour cells, and as a consequence, promotes tumour cell lipid peroxidation and ferroptosis. Cystine 207-214 interferon gamma Homo sapiens 17-44 31183395-7 2019 Quantitative real-time PCR demonstrated that higher expression levels of IFN-gamma but muted IL-2 and KLRG-1 expression was detected in the cervix of patients with HPV16+ compared to HPV18+, which were further confirmed using 20 paraffin sections of cervical conization tissue. Paraffin 229-237 interferon gamma Homo sapiens 73-82 30971412-9 2019 For M1-like macrophage markers, we observed an increase in TNF-alpha+ and IFN-gamma+ cells, Cxcl-9 and Cxcl-10 expressions in PPE and CS groups. Cesium 134-136 interferon gamma Homo sapiens 74-83 31025190-1 2019 Natural hIFNgamma is a glycoprotein with two N-glycosylation sites in each monomer chain, which are independently and differentially glycosylated. Nitrogen 0-1 interferon gamma Homo sapiens 8-17 31068935-10 2019 Functional assays showed that proliferating T-cells expressing immune checkpoints produced less IFN-gamma, TNF-alpha, and CD107a after restimulation when CAFs had been present. cafs 154-158 interferon gamma Homo sapiens 96-105 31025190-7 2019 We show that the glycans restrict the C-termini wagging motion into the solvent, limit their flexibility and keep them closer to the alpha-helical globule of hIFNgamma, thus possibly protecting them from proteolytic processing. Polysaccharides 17-24 interferon gamma Homo sapiens 158-167 31002701-8 2019 Interestingly, GSK2256294 reduced IL4 and IFNgamma in ulcerative colitis, and IL1beta in Crohn"s disease specifically, suggesting potential differential effects of GSK2256294 in these two diseases. N-((4-cyano-2-(trifluoromethyl)phenyl)methyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexanecarboxamide 15-25 interferon gamma Homo sapiens 42-50 30829471-6 2019 More importantly, the probe revealed that NO induced by interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), and l-arginine (l-Arg) could also elicit the augmentation of intracellular GSH. Arginine 128-133 interferon gamma Homo sapiens 56-72 30998783-5 2019 As for effector functions, IFNgamma/TNF responses to phosphoantigens or PMA/Ionomycin in Vdelta2+gammadeltaT-cells were weaker in AHB but preserved in CHB, without significant differences for Vdelta1+gammadeltaT-cells. Ionomycin 76-85 interferon gamma Homo sapiens 27-35 30998783-6 2019 Furthermore, early IFNgamma/TNF responses in Vdelta2+ gammadeltaT-cells to brief PMA/Ionomycin stimulation correlated inversely with serum ALT but not HBV DNA. Ionomycin 85-94 interferon gamma Homo sapiens 19-27 30848916-3 2019 In this study, we capitalized on two ADP-ribosylation enrichment strategies, and multiple activation methods performed on the Orbitrap Fusion Lumos, to identify IFN-gamma-induced ADP-ribosylation substrates in macrophages. Adenosine Diphosphate 37-40 interferon gamma Homo sapiens 161-170 30848916-8 2019 IFN-gamma increased the ADP-ribosylation status of ARTD9/PARP9, ARTD8/PARP14, and proteins involved in RNA processes. Adenosine Diphosphate 24-27 interferon gamma Homo sapiens 0-9 30943938-9 2019 The SA group showed higher concentrations of Th1- (IL-6, TNF-alpha, IL-2, IFN-gamma) and Th2- (IL-4, and IL-10) related cytokines than the controls. sa 4-6 interferon gamma Homo sapiens 74-83 30943978-7 2019 Extensive aerosol studies (aerosol output and droplet analysis, non-invasive and invasive aerosol therapy) were conducted in line with regulatory requirements and characterization of the stability and bioactivity of the IFN-gamma post-nebulization was confirmed using SDS-PAGE and stimulation of Human C-X-C motif chemokine 10 (CXCL 10) also known as IFN-gamma-induced protein 10KDa (IP 10) expression from THP-1 derived macrophages (THP-1 cells). Sodium Dodecyl Sulfate 268-271 interferon gamma Homo sapiens 220-229 30943978-12 2019 SDS-PAGE gels indicated that IFN-gamma remains stable after nebulization by both devices and this was confirmed by bioactivity studies using a THP-1 cell model in which an alveolar macrophage response to IFN-gamma was determined. Sodium Dodecyl Sulfate 0-3 interferon gamma Homo sapiens 29-38 30943978-12 2019 SDS-PAGE gels indicated that IFN-gamma remains stable after nebulization by both devices and this was confirmed by bioactivity studies using a THP-1 cell model in which an alveolar macrophage response to IFN-gamma was determined. Sodium Dodecyl Sulfate 0-3 interferon gamma Homo sapiens 204-213 30777330-5 2019 The administration of EV71 nanovaccine elicited not only specific anti-EV71 neutralizing antibody response, but also cellular immune response characterized by strong productions of IFN-alpha and IFN-gamma. nanovaccine 27-38 interferon gamma Homo sapiens 195-204 30782482-8 2019 Additional exposure of IFN-gamma-primed AAA-SMC to CD for 6-24 h, further augmented expression of AIM2, NLRP3, and Caspase-1 protein levels. Cadmium 51-53 interferon gamma Homo sapiens 23-32 30782482-9 2019 Analysis of the SMC supernatants by ELISA revealed CD-induced release of the senescence-associated cytokines IL-6 and MCP-1 in native and IFN-gamma-primed SMC, whereas no secretion of Interleukin-(IL) 1alpha and IL-1beta secretion were observed. Cadmium 51-53 interferon gamma Homo sapiens 138-147 30803759-3 2019 Interferon-gamma (IFN-gamma)/lipopolysaccharide (LPS) treatment triggers microglial activation and the reduction of dopamine neurons in midbrain slice cultures. Dopamine 116-124 interferon gamma Homo sapiens 0-16 30803759-3 2019 Interferon-gamma (IFN-gamma)/lipopolysaccharide (LPS) treatment triggers microglial activation and the reduction of dopamine neurons in midbrain slice cultures. Dopamine 116-124 interferon gamma Homo sapiens 18-27 30803759-9 2019 IFN-gamma/LPS treatment to the midbrain slice cultures activated microglia, increased exosomal release, and decreased dopamine neurons. Dopamine 118-126 interferon gamma Homo sapiens 0-9 30803759-10 2019 GW4869, an inhibitor of a neutral sphingomyelinase 2, decreased exosomal release and significantly prevented dopaminergic neurodegeneration by IFN-gamma/LPS without affecting NO production. GW 4869 0-6 interferon gamma Homo sapiens 143-152 30952714-10 2019 Furthermore, anti-PD-L1 alone and in combination with cisplatin, but not cisplatin alone, induced interferon-gamma-producing CD4+ T-cells. Cisplatin 54-63 interferon gamma Homo sapiens 98-114 30910955-6 2019 Increased glucose uptake and IFN-gamma expression in NKT cells is inversely correlated with bacterial loads in response to bacterial infection, further supporting the significance of glucose metabolism for NKT cell function. Glucose 183-190 interferon gamma Homo sapiens 29-38 30829471-6 2019 More importantly, the probe revealed that NO induced by interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), and l-arginine (l-Arg) could also elicit the augmentation of intracellular GSH. Arginine 116-126 interferon gamma Homo sapiens 56-72 30952766-1 2019 AIM: We previously reported that sorafenib induces Th1 [interferon-gamma (IFNgamma)-positive interleukin 4 (IL4)-negative] dominance which prevents tumor cells from escaping the host immune system in patients with liver cirrhosis (LC) and advanced hepatocellular carcinoma (aHCC). Sorafenib 33-42 interferon gamma Homo sapiens 56-72 30829471-6 2019 More importantly, the probe revealed that NO induced by interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), and l-arginine (l-Arg) could also elicit the augmentation of intracellular GSH. Arginine 128-133 interferon gamma Homo sapiens 74-83 30952766-1 2019 AIM: We previously reported that sorafenib induces Th1 [interferon-gamma (IFNgamma)-positive interleukin 4 (IL4)-negative] dominance which prevents tumor cells from escaping the host immune system in patients with liver cirrhosis (LC) and advanced hepatocellular carcinoma (aHCC). Sorafenib 33-42 interferon gamma Homo sapiens 74-82 30952766-6 2019 In patients receiving sorafenib at a dose of 400 mg/day, patients in Child-Pugh class A, and patients with stage IVA aHCC, Th2 (IFNgamma-negative/IL4-positive) cells decreased significantly after treatment, although there was no significant impact on the tumor response. Sorafenib 22-31 interferon gamma Homo sapiens 128-136 30829471-6 2019 More importantly, the probe revealed that NO induced by interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), and l-arginine (l-Arg) could also elicit the augmentation of intracellular GSH. Glutathione 187-190 interferon gamma Homo sapiens 56-72 30829471-6 2019 More importantly, the probe revealed that NO induced by interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), and l-arginine (l-Arg) could also elicit the augmentation of intracellular GSH. Glutathione 187-190 interferon gamma Homo sapiens 74-83 30477320-10 2019 CONCLUSIONS: In obese individuals, more sensitive to the damaging effects of environmental air pollution, PM10 exposure positively associates with proprotein convertase subtilisin/kexin type 9 plasma levels especially in those with low levels of interferon-gamma. pm10 106-110 interferon gamma Homo sapiens 246-262 30696657-4 2019 Pomalidomide-induced absence of alternatively activated macrophages led to a decrease in fibrosis at PanIN lesions and in syngeneic tumors; this was due to generation of an inflammatory, immune-responsive environment with increased expression of IL1alpha and presence of activated (IFNgamma-positive) CD4+ and CD8+ T-cell populations. pomalidomide 0-12 interferon gamma Homo sapiens 282-290 31084433-6 2019 Other shared functions of vitamin A and vitamin D include the support of innate lymphoid cells that produce IL-22, suppression of IFN-gamma and IL-17 by T cells, and induction of regulatory T cells in the mucosal tissues. Vitamin A 26-35 interferon gamma Homo sapiens 130-139 31084433-6 2019 Other shared functions of vitamin A and vitamin D include the support of innate lymphoid cells that produce IL-22, suppression of IFN-gamma and IL-17 by T cells, and induction of regulatory T cells in the mucosal tissues. Vitamin D 40-49 interferon gamma Homo sapiens 130-139 31056985-0 2019 Inhibition of interferon-gamma production and T-bet expression by menthol treatment of human peripheral blood mononuclear cells. Menthol 66-73 interferon gamma Homo sapiens 14-30 30907193-5 2019 Results: The production of IFN-gamma and IL-17 was increased in untreated (without sitagliptin and VitD3) nephropathic and non-nephropathic T2DM patients compared with healthy controls, whereas FOXP3 expression was decreased. Sitagliptin Phosphate 83-94 interferon gamma Homo sapiens 27-36 30907193-6 2019 Treatment with sitagliptin alone or in combination with VitD3 reduced the production of IFN-gamma in the patients. Sitagliptin Phosphate 15-26 interferon gamma Homo sapiens 88-97 30907193-8 2019 Conclusion: These data demonstrate that sitagliptin in combination with VitD3 may accelerate the process of T2DM treatment by exerting synergic anti-inflammatory effects on immune system through upregulation of FOXP3 and IL-37, and downregulation of RORgammat and BCL6 as well as IFN-gamma, IL-17 and IL-21 production. Sitagliptin Phosphate 40-51 interferon gamma Homo sapiens 280-289 31056985-6 2019 Menthol dose-dependently decreased IFNgamma but not IL-4 production in culture of PHA- and PMA/CI-stimulated lymphocytes to more than 80% at 800 microg/ml. Menthol 0-7 interferon gamma Homo sapiens 35-43 31056985-7 2019 In flow cytometry analysis, menthol reduced the number of IFN-gamma-expressing CD4+T cells stimulated either with PHA or PMA/CI. Menthol 28-35 interferon gamma Homo sapiens 58-67 31056985-11 2019 Conclusion: Decreased IFNgamma expression plus T-bet down-regulation suggested the inhibitory effect of menthol on Th1 cells differentiation and hence imply its possible therapeutic usefulness in inflammatory diseases. Menthol 104-111 interferon gamma Homo sapiens 22-30 30582995-0 2019 Evaluating results of an interferon-gamma release assay in patients with autoimmune disease who are taking hydroxychloroquine. Hydroxychloroquine 107-125 interferon gamma Homo sapiens 25-41 31135880-5 2019 We first find that the cytokine secretion profile for hMSCs cultured within synthetic poly(ethylene glycol)-based hydrogels is significantly different compared to those cultured on glass substrates, both in growth media and following stimulation with IFN-gamma and TNF-alpha, for cells derived from two donors. Polyethylene Glycols 86-107 interferon gamma Homo sapiens 251-260 30092288-11 2019 JH2 ATP site targeting has the potential for reduced side effects by retaining erythropoietin and IFN-gamma functions. Adenosine Triphosphate 4-7 interferon gamma Homo sapiens 98-107 31168339-5 2019 Results: Immunization with CS stimulated higher interferon gamma (IFN-gamma) immunity, while there were no significant differences between rOMP25 (IFA), rOMP25 (AH), rOMP25 (AH-CS) and rOMP25 (IFA-CS) recombinant proteins. Cesium 27-29 interferon gamma Homo sapiens 48-75 30769026-5 2019 The mRNA levels of IFN-gamma was examined in (n = 23) polyomavirus BK infected and (n = 23) non-infected kidney transplant patients in comparison with healthy controls (n = 23), using an in-house Real time PCR (SYBR Green) assay. sybr green 211-221 interferon gamma Homo sapiens 19-28 30776726-8 2019 By studying intracellular mechanisms triggered by IL-10 and IFN-gamma, we demonstrated that they specifically induced PI3K-dependent serine-phosphorylation of signal transducer and activator of transcription (STAT)3 or STAT1, respectively. Serine 133-139 interferon gamma Homo sapiens 60-69 30886419-6 2019 This engraftment led to interferon-gamma-dependent functional changes in the pool of MMs, including loss of bacterial and immunoregulatory sensors. Methyl Methanesulfonate 85-88 interferon gamma Homo sapiens 24-40 30850240-15 2019 CONCLUSIONS: IL-6 and IFN-gamma signals were associated with systemic reactogenicity following administration of AS01B-adjuvanted vaccine. as01b 113-118 interferon gamma Homo sapiens 22-31 30921340-8 2019 It was observed that DNA priming and MVA boosting induced Env and Gag specific bi-functional and multi-functional CD4+ and CD8+ T cells expressing IFN-gamma, TNF-alpha and IL-2. Glycosaminoglycans 66-69 interferon gamma Homo sapiens 147-156 31110712-0 2019 Immunotherapy of lidocaine allergy by intravenous desensitization using IFN-gamma from a case: Overcoming impediments using IFN-gamma during desensitization. Lidocaine 17-26 interferon gamma Homo sapiens 72-81 30971638-12 2019 IFN-gamma production, which is induced by CO exposure via guanylate cyclase activation-mediated cGMP production, may be involved in RV14 replication inhibition. Cyclic GMP 96-100 interferon gamma Homo sapiens 0-9 31110712-0 2019 Immunotherapy of lidocaine allergy by intravenous desensitization using IFN-gamma from a case: Overcoming impediments using IFN-gamma during desensitization. Lidocaine 17-26 interferon gamma Homo sapiens 124-133 31110712-2 2019 In this trial, a patient who required local anesthesia for dental treatment was desensitized successfully to intravenous lidocaine using IFN-gamma. Lidocaine 121-130 interferon gamma Homo sapiens 137-146 30911044-6 2019 However, pre-treatment of PBMCs with physiologically-relevant concentrations of genistein (p = 0.0023) and equol (p = 0.006) decreases interleukin (IL)-12/IL-18-induced interferon-gamma (IFN-gamma) production versus controls. Genistein 80-89 interferon gamma Homo sapiens 169-185 30911044-6 2019 However, pre-treatment of PBMCs with physiologically-relevant concentrations of genistein (p = 0.0023) and equol (p = 0.006) decreases interleukin (IL)-12/IL-18-induced interferon-gamma (IFN-gamma) production versus controls. Genistein 80-89 interferon gamma Homo sapiens 187-196 30911044-6 2019 However, pre-treatment of PBMCs with physiologically-relevant concentrations of genistein (p = 0.0023) and equol (p = 0.006) decreases interleukin (IL)-12/IL-18-induced interferon-gamma (IFN-gamma) production versus controls. Equol 107-112 interferon gamma Homo sapiens 169-185 30911044-6 2019 However, pre-treatment of PBMCs with physiologically-relevant concentrations of genistein (p = 0.0023) and equol (p = 0.006) decreases interleukin (IL)-12/IL-18-induced interferon-gamma (IFN-gamma) production versus controls. Equol 107-112 interferon gamma Homo sapiens 187-196 30898149-14 2019 However, the addition of anti-PD-L1 to N-803 significantly enhanced CD8+ T cell effector function versus N-803 and anti-PD-L1 monotherapies, as indicated by increased Granzyme B and IFNgamma production, at the site of metastasis and in the periphery. n-803 39-44 interferon gamma Homo sapiens 182-190 30956773-7 2019 These results suggest that panobinostat enhances PD-L1 expression by facilitating the IFN-gamma-STAT1 pathway in a ligand-dependent manner in MM cells with ambient IFN-gamma. Panobinostat 27-39 interferon gamma Homo sapiens 86-95 30941128-10 2019 Fetal liver and spleen NK cells displayed limited cytotoxic effector function in chromium release assays but produced copious amounts of TNFalpha and IFNgamma, and degranulated efficiently in response to stimulation with PMA/ionomycin. Tetradecanoylphorbol Acetate 221-224 interferon gamma Homo sapiens 150-158 30956773-7 2019 These results suggest that panobinostat enhances PD-L1 expression by facilitating the IFN-gamma-STAT1 pathway in a ligand-dependent manner in MM cells with ambient IFN-gamma. Panobinostat 27-39 interferon gamma Homo sapiens 164-173 30956980-4 2019 RT-qPCR data confirmed the accuracy of microarray data, and cytokines assay results indicated that 6 of the total 27 inflammatory cytokine secretions were significantly inhibited by myricetin pretreatment, including TNF-alpha, IFN-gamma, IL-1alpha, IL-1beta, IL-2, and IL-6. myricetin 182-191 interferon gamma Homo sapiens 227-236 30866565-5 2019 Several fatty acids were associated with interferon-gamma (IFNgamma) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Fatty Acids 8-19 interferon gamma Homo sapiens 41-57 30866565-5 2019 Several fatty acids were associated with interferon-gamma (IFNgamma) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Fatty Acids 8-19 interferon gamma Homo sapiens 59-67 30866565-7 2019 Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN-gamma at 1 year. Fatty Acids, Omega-3 0-19 interferon gamma Homo sapiens 82-91 30782607-8 2019 Interferon gamma (IFNgamma) promoted gemcitabine-induced cell apoptosis and inhibited cell proliferation in vitro and in vivo by FOXM1 inhibition. gemcitabine 37-48 interferon gamma Homo sapiens 0-16 30862026-2 2019 Interferon gamma-inducible (the production of which is dependent on the IFNgamma rs2430561 polymorphism) tryptophan-kynurenine inflammatory cascade helps to understand the increased association between inflammatory process and MetS, which is why we seek the relationship between the IFNgamma gene polymorphisms and serum levels of markers of interferon-gamma (IFNgamma)-inducible inflammatory cascade. Tryptophan 105-115 interferon gamma Homo sapiens 72-80 30862026-2 2019 Interferon gamma-inducible (the production of which is dependent on the IFNgamma rs2430561 polymorphism) tryptophan-kynurenine inflammatory cascade helps to understand the increased association between inflammatory process and MetS, which is why we seek the relationship between the IFNgamma gene polymorphisms and serum levels of markers of interferon-gamma (IFNgamma)-inducible inflammatory cascade. Tryptophan 105-115 interferon gamma Homo sapiens 283-291 30862026-2 2019 Interferon gamma-inducible (the production of which is dependent on the IFNgamma rs2430561 polymorphism) tryptophan-kynurenine inflammatory cascade helps to understand the increased association between inflammatory process and MetS, which is why we seek the relationship between the IFNgamma gene polymorphisms and serum levels of markers of interferon-gamma (IFNgamma)-inducible inflammatory cascade. Tryptophan 105-115 interferon gamma Homo sapiens 342-358 30862026-2 2019 Interferon gamma-inducible (the production of which is dependent on the IFNgamma rs2430561 polymorphism) tryptophan-kynurenine inflammatory cascade helps to understand the increased association between inflammatory process and MetS, which is why we seek the relationship between the IFNgamma gene polymorphisms and serum levels of markers of interferon-gamma (IFNgamma)-inducible inflammatory cascade. Tryptophan 105-115 interferon gamma Homo sapiens 283-291 30862026-2 2019 Interferon gamma-inducible (the production of which is dependent on the IFNgamma rs2430561 polymorphism) tryptophan-kynurenine inflammatory cascade helps to understand the increased association between inflammatory process and MetS, which is why we seek the relationship between the IFNgamma gene polymorphisms and serum levels of markers of interferon-gamma (IFNgamma)-inducible inflammatory cascade. Kynurenine 116-126 interferon gamma Homo sapiens 72-80 30862026-2 2019 Interferon gamma-inducible (the production of which is dependent on the IFNgamma rs2430561 polymorphism) tryptophan-kynurenine inflammatory cascade helps to understand the increased association between inflammatory process and MetS, which is why we seek the relationship between the IFNgamma gene polymorphisms and serum levels of markers of interferon-gamma (IFNgamma)-inducible inflammatory cascade. Kynurenine 116-126 interferon gamma Homo sapiens 283-291 30862026-2 2019 Interferon gamma-inducible (the production of which is dependent on the IFNgamma rs2430561 polymorphism) tryptophan-kynurenine inflammatory cascade helps to understand the increased association between inflammatory process and MetS, which is why we seek the relationship between the IFNgamma gene polymorphisms and serum levels of markers of interferon-gamma (IFNgamma)-inducible inflammatory cascade. Kynurenine 116-126 interferon gamma Homo sapiens 342-358 30862026-2 2019 Interferon gamma-inducible (the production of which is dependent on the IFNgamma rs2430561 polymorphism) tryptophan-kynurenine inflammatory cascade helps to understand the increased association between inflammatory process and MetS, which is why we seek the relationship between the IFNgamma gene polymorphisms and serum levels of markers of interferon-gamma (IFNgamma)-inducible inflammatory cascade. Kynurenine 116-126 interferon gamma Homo sapiens 283-291 30862026-6 2019 In the group with MetS, the A/T genotype of the IFNgamma gene was accompanied by higher kynurenine levels. Kynurenine 88-98 interferon gamma Homo sapiens 48-56 30862026-8 2019 A disparity in the kynurenine level, as well as the relationship between the presence of the A/T genotype of the IFNgamma gene and a higher level of kynurenine in the group of women with MetS, may indicate an association between inflammation, metabolic disorders and tryptophan-kynurenine inflammatory cascade. Kynurenine 149-159 interferon gamma Homo sapiens 113-121 30862026-8 2019 A disparity in the kynurenine level, as well as the relationship between the presence of the A/T genotype of the IFNgamma gene and a higher level of kynurenine in the group of women with MetS, may indicate an association between inflammation, metabolic disorders and tryptophan-kynurenine inflammatory cascade. Tryptophan 267-277 interferon gamma Homo sapiens 113-121 30862026-8 2019 A disparity in the kynurenine level, as well as the relationship between the presence of the A/T genotype of the IFNgamma gene and a higher level of kynurenine in the group of women with MetS, may indicate an association between inflammation, metabolic disorders and tryptophan-kynurenine inflammatory cascade. Kynurenine 149-159 interferon gamma Homo sapiens 113-121 30075952-6 2019 A biomimetic calcium phosphate coating (bCaP) physically and temporally separated the pro-inflammatory stimulus interferon-gamma (IFNgamma) from the pro-reparative stimulus simvastatin (SIMV). calcium phosphate 13-30 interferon gamma Homo sapiens 112-128 30075952-6 2019 A biomimetic calcium phosphate coating (bCaP) physically and temporally separated the pro-inflammatory stimulus interferon-gamma (IFNgamma) from the pro-reparative stimulus simvastatin (SIMV). calcium phosphate 13-30 interferon gamma Homo sapiens 130-138 30832595-8 2019 The frequency of IFN-gamma produced by CD4+ and CD8+ T cells showed significant positive association with age and alanine aminotransferase (ALT) level, while that had negative association with qHBsAg titers. qhbsag 193-199 interferon gamma Homo sapiens 17-26 30409776-2 2019 Azacitidine upregulates PD-1 and IFNgamma signaling. Azacitidine 0-11 interferon gamma Homo sapiens 33-41 30782607-8 2019 Interferon gamma (IFNgamma) promoted gemcitabine-induced cell apoptosis and inhibited cell proliferation in vitro and in vivo by FOXM1 inhibition. gemcitabine 37-48 interferon gamma Homo sapiens 18-26 30782607-10 2019 IFNgamma could be used to down-regulate the expression of FOXM1 through STAT1 phosphorylation, thereby increasing the sensitivity of pancreatic cancer cells to gemcitabine. gemcitabine 160-171 interferon gamma Homo sapiens 0-8 31074416-10 2019 The levels of IL-2, IL-4, IL-10, IFN-gamma, and IL-17 correlated positively with the levels of serum creatinine. Creatinine 101-111 interferon gamma Homo sapiens 33-42 30638709-6 2019 Treatment ex vivo with TPC decreased the production of IL-1beta, IL-2, IL-5, IL-6, IL-9, IL-12(p70), IL-13, IL-17A, IL-18, IL-21, IL-22, IL-23, IFNgamma, TNFalpha, GM-CSF by CD3/CD28 activated PBMCs whereas it negligibly affected cell viability. tpc 23-26 interferon gamma Homo sapiens 144-152 30155911-3 2019 AIM: To explore the immunomodulation of icariin on cutaneous HPAA by detecting the response to the inflammatory cytokines tumour necrosis factor-alpha/interferon-gamma in HaCaT cells. icariin 40-47 interferon gamma Homo sapiens 151-167 30260027-4 2019 In cells from normal controls and CGD patients, IFN-gamma-induced expression of genes relevant to oxidative killing, nitric oxide synthase pathway, proteasome-mediated degradation, antigen presentation, chemoattraction, and cell adhesion. Nitric Oxide 117-129 interferon gamma Homo sapiens 48-57 30260038-5 2019 RESULTS: The main results showed that the concentration of IFN-gamma in the DH group was significantly higher than the D, H, and CTL groups, IL-6 in DH and D groups was significantly lower than the CTL group. Dihydrotestosterone 76-78 interferon gamma Homo sapiens 59-68 30638860-10 2019 GSEA showed that the complemen, metabolism, apoptosis, interferon-gamma response, inflammatory response, Notch, Kras, reactive oxygen species, VEGF, IL-6/JAK/STAT3, IL-2/Stat5, B-cell receptor, and p53 pathways were significantly associated with the STAT5A gene. gsea 0-4 interferon gamma Homo sapiens 55-71 30820177-2 2019 It is known that neopterin levels increase in diseases where interferon-gamma (IFN-g) stimulation is present, and also as a result of deficiencies in renal function, given that the primary means of elimination of neopterin is through the kidneys. Neopterin 17-26 interferon gamma Homo sapiens 61-77 30820177-2 2019 It is known that neopterin levels increase in diseases where interferon-gamma (IFN-g) stimulation is present, and also as a result of deficiencies in renal function, given that the primary means of elimination of neopterin is through the kidneys. Neopterin 17-26 interferon gamma Homo sapiens 79-84 30625033-3 2019 While barely detectable Y280 phosphorylation was observed in confluent monolayers of human intestinal epithelial cells under basal conditions, exposure to cytokines TNFalpha, IFNgamma, IL-22, or IL-17A, resulted in compromised barrier function in parallel with increased p-Y280. y280 24-28 interferon gamma Homo sapiens 175-183 30946728-2 2019 Over the past several years Vitamin D has been recognized as a hormone with significant immunomodulatory effect due to the fact that it inhibits T-cell proliferation and decreases the production of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha. Vitamin D 28-37 interferon gamma Homo sapiens 213-262 31089437-8 2019 Furthermore, the functional activity was dramatically improved in the TT group, showing enhanced production of IFNgamma in CD8+ T cells compared with the BT group. 6-thiotheophylline 70-72 interferon gamma Homo sapiens 111-119 30873207-11 2019 Taken together, bioinformatics analysis revealed these lncRNAs were involved in regulating the leukotriene biosynthetic process, gene expression, actin filament organization, t-circle formation, antigen processing, and presentation, interferon-gamma-mediated signaling pathway, and activation of GTPase activity. Leukotrienes 95-106 interferon gamma Homo sapiens 233-249 30781490-7 2019 Significant release of IFN-gamma suggests PDL1-Dox can upmodulate T cell activation. Doxorubicin 47-50 interferon gamma Homo sapiens 23-32 30787167-5 2019 Sodium chloride enhanced interleukin-4 (IL-4) and IL-13 production while suppressing interferon-gamma (IFN-gamma) production in memory T cells. Sodium Chloride 0-15 interferon gamma Homo sapiens 85-101 30787167-5 2019 Sodium chloride enhanced interleukin-4 (IL-4) and IL-13 production while suppressing interferon-gamma (IFN-gamma) production in memory T cells. Sodium Chloride 0-15 interferon gamma Homo sapiens 103-112 30838000-8 2019 Upon in vitro activation with PMA plus ionomycin or IL12 plus IL18, fewer MAIT cells isolated from the young adult group expressed IFN-gamma, IL17A and Granzyme B then cells from other age groups while the proportion of cells that expressed TNF-alpha was similar. Tetradecanoylphorbol Acetate 30-33 interferon gamma Homo sapiens 131-140 30838000-8 2019 Upon in vitro activation with PMA plus ionomycin or IL12 plus IL18, fewer MAIT cells isolated from the young adult group expressed IFN-gamma, IL17A and Granzyme B then cells from other age groups while the proportion of cells that expressed TNF-alpha was similar. Ionomycin 39-48 interferon gamma Homo sapiens 131-140 30931336-14 2019 Furthermore, they could demonstrate that treatment with the immunosuppressive drug tacrolimus resulted in decreased CMV-specific IFN-gamma and of IL-21 production. Tacrolimus 83-93 interferon gamma Homo sapiens 129-138 30770758-8 2019 RESULTS: Supplementation with L-theanine contributed to a significant post-exercise decrease in IL-10 concentration, which was reflected by higher values of IL-2 to IL-10 and IFN-gamma to IL-10 ratios. theanine 30-40 interferon gamma Homo sapiens 175-184 30269272-9 2019 Concomitantly, only homoectoine ameliorated the drop in transepithelial electrical resistance induced by IFN-gamma and TNF-alpha in Caco-2 cells. (7S)-4,5,6,7-Tetrahydro-2-methyl-1H-1,3-Diazepine-7-carboxylicacid 20-31 interferon gamma Homo sapiens 105-114 30828332-9 2019 Importantly, ex vivo exposure of ILC3 and ILC1 to fingolimod or SEW2871, another S1PR1 antagonist, reduced production of ILC3- and ILC1- associated cytokines GM-CSF, IL-22, IL-17, and IFN-gamma, respectively. SEW2871 64-71 interferon gamma Homo sapiens 184-193 30472069-6 2019 We determined that tacrolimus profoundly suppressed CD4 and CD8 T cell proliferation and significantly suppressed Th1 and Th17 responses, as demonstrated by a reduced frequency of IFN-gamma, IL-2, and IL-17 producing CD4 T cells and reduced frequencies of IFN-gamma and IL-2 producing CD8 T cells. Tacrolimus 19-29 interferon gamma Homo sapiens 180-189 30472069-6 2019 We determined that tacrolimus profoundly suppressed CD4 and CD8 T cell proliferation and significantly suppressed Th1 and Th17 responses, as demonstrated by a reduced frequency of IFN-gamma, IL-2, and IL-17 producing CD4 T cells and reduced frequencies of IFN-gamma and IL-2 producing CD8 T cells. Tacrolimus 19-29 interferon gamma Homo sapiens 256-265 30472069-7 2019 Tacrolimus also inhibits pathogenic Th17 cells coproducing IL-17 and IFN-gamma. Tacrolimus 0-10 interferon gamma Homo sapiens 69-78 30828332-9 2019 Importantly, ex vivo exposure of ILC3 and ILC1 to fingolimod or SEW2871, another S1PR1 antagonist, reduced production of ILC3- and ILC1- associated cytokines GM-CSF, IL-22, IL-17, and IFN-gamma, respectively. Fingolimod Hydrochloride 50-60 interferon gamma Homo sapiens 184-193 29429995-8 2019 Additionally, miR-125b-5p knockdown facilitated the cytotoxicity of gammadelta T cells toward tumor cells in vitro by increasing degranulation and secretion of IFN-gamma and TNF-alpha. mir-125b 14-22 interferon gamma Homo sapiens 160-169 30269272-10 2019 Both ectoines inhibited loss of ZO-1 and occludin and prevented IFN-gamma/TNF-alpha-induced increased paracellular flux of 4 kDa FITC-dextran in vitro. fluorescein isothiocyanate dextran 129-141 interferon gamma Homo sapiens 64-73 30178232-13 2019 Additionally, IFN-gamma production by Th1 cells was decreased after treatment silymarin in newly diagnosed patients; however, in IFN-beta treated after 48-h treatment with silymarin, IFN-gamma concentration was decreased at concentrations of 100 and 150 muM, and after 120 h, a significant increase was observed in the IFN-gamma level at a concentration of 100 muM in comparison with DMSO. Silymarin 172-181 interferon gamma Homo sapiens 183-192 30178232-13 2019 Additionally, IFN-gamma production by Th1 cells was decreased after treatment silymarin in newly diagnosed patients; however, in IFN-beta treated after 48-h treatment with silymarin, IFN-gamma concentration was decreased at concentrations of 100 and 150 muM, and after 120 h, a significant increase was observed in the IFN-gamma level at a concentration of 100 muM in comparison with DMSO. Silymarin 78-87 interferon gamma Homo sapiens 14-23 30178232-13 2019 Additionally, IFN-gamma production by Th1 cells was decreased after treatment silymarin in newly diagnosed patients; however, in IFN-beta treated after 48-h treatment with silymarin, IFN-gamma concentration was decreased at concentrations of 100 and 150 muM, and after 120 h, a significant increase was observed in the IFN-gamma level at a concentration of 100 muM in comparison with DMSO. Silymarin 172-181 interferon gamma Homo sapiens 183-192 30178232-13 2019 Additionally, IFN-gamma production by Th1 cells was decreased after treatment silymarin in newly diagnosed patients; however, in IFN-beta treated after 48-h treatment with silymarin, IFN-gamma concentration was decreased at concentrations of 100 and 150 muM, and after 120 h, a significant increase was observed in the IFN-gamma level at a concentration of 100 muM in comparison with DMSO. Dimethyl Sulfoxide 384-388 interferon gamma Homo sapiens 14-23 30178232-13 2019 Additionally, IFN-gamma production by Th1 cells was decreased after treatment silymarin in newly diagnosed patients; however, in IFN-beta treated after 48-h treatment with silymarin, IFN-gamma concentration was decreased at concentrations of 100 and 150 muM, and after 120 h, a significant increase was observed in the IFN-gamma level at a concentration of 100 muM in comparison with DMSO. Dimethyl Sulfoxide 384-388 interferon gamma Homo sapiens 183-192 30178232-13 2019 Additionally, IFN-gamma production by Th1 cells was decreased after treatment silymarin in newly diagnosed patients; however, in IFN-beta treated after 48-h treatment with silymarin, IFN-gamma concentration was decreased at concentrations of 100 and 150 muM, and after 120 h, a significant increase was observed in the IFN-gamma level at a concentration of 100 muM in comparison with DMSO. Dimethyl Sulfoxide 384-388 interferon gamma Homo sapiens 183-192 30675308-4 2019 Therefore, in vitro experiments with human lymphoma cell lines SU-DHL-4 and Daudi (both CD40 positive) and human breast adenocarcinoma MCF-7 (GITRL positive) were performed and the secretion of interferon (IFN)-gamma was measured. su-dhl-4 63-71 interferon gamma Homo sapiens 194-216 30211958-4 2019 It has been previously shown that Rv0140, a reactivation-associated antigen of Mtb, induces significantly higher IFN-gamma production in LTBI individuals as compared to aTB patients. rv0140 34-40 interferon gamma Homo sapiens 113-122 30211958-6 2019 Receiving operator characteristic (ROC) curves were used to evaluate the capacity of Rv0140 to discriminate between LTBI and aTB by measuring IFN-gamma and granzyme B secretion. rv0140 85-91 interferon gamma Homo sapiens 142-151 30392853-5 2019 In addition, the glucan induced a tendency to increase the secreted levels of the anti-inflammatory cytokine IL-10, enhanced the expression levels of CCL2 and CCL8 mRNAs, and inhibited expression of CCR2 mRNA in the IFNgamma/LPS activated macrophages. Glucans 17-23 interferon gamma Homo sapiens 216-224 30088084-7 2019 Further examination demonstrated that blockade of autophagy in beta-glucan-induced DCs significantly attenuated IFN-gamma production by co-cultured CD4 + T cells and inhibited the proliferation and differentiation of CD4 + T cells. beta-Glucans 63-74 interferon gamma Homo sapiens 112-121 30073504-0 2019 Correction to: Sneaky Entry of IFNgamma Through Arsenic-Induced Leaky Blood-Brain Barrier Reduces CD200 Expression by Microglial pro-Inflammatory Cytokine. Arsenic 48-55 interferon gamma Homo sapiens 31-39 30700717-4 2019 Inhibition of the cholesterol biosynthesis pathway with atorvastatin or 25-hydroxycholesterol during switching from IFNgamma+ to IL-10+ shows a specific block in immune resolution, defined as a significant decrease in IL-10 expression. Cholesterol 18-29 interferon gamma Homo sapiens 116-124 30783507-3 2019 The in vivo evaluation of immunostimulatory activities revealed that the synthesized alpha-5-thio-galactopyranosyl-N-perfluorooctanoyl phytosphingosine exhibited a remarkable potency toward selectively enhancing TH1 cytokine production with the IFN gamma/IL-4 ratio of 9/1, while its perfluorotetradecanoyl counterpart showed TH2 profile with an IFN gamma/IL-4 ratio of 0.59/1. alpha-5-thio-galactopyranosyl-n-perfluorooctanoyl phytosphingosine 85-151 interferon gamma Homo sapiens 245-254 30783507-3 2019 The in vivo evaluation of immunostimulatory activities revealed that the synthesized alpha-5-thio-galactopyranosyl-N-perfluorooctanoyl phytosphingosine exhibited a remarkable potency toward selectively enhancing TH1 cytokine production with the IFN gamma/IL-4 ratio of 9/1, while its perfluorotetradecanoyl counterpart showed TH2 profile with an IFN gamma/IL-4 ratio of 0.59/1. alpha-5-thio-galactopyranosyl-n-perfluorooctanoyl phytosphingosine 85-151 interferon gamma Homo sapiens 346-355 30783516-4 2019 IFNgamma-producing NPM1-mutated-specific T cells were observed by ELISPOT assay after stimulation with peptides 13.9-14.9 in 43/85 (50.6%) PB and 34/80 (42.5%) BM samples. Peptides 103-111 interferon gamma Homo sapiens 0-9 30783516-4 2019 IFNgamma-producing NPM1-mutated-specific T cells were observed by ELISPOT assay after stimulation with peptides 13.9-14.9 in 43/85 (50.6%) PB and 34/80 (42.5%) BM samples. Lead 139-141 interferon gamma Homo sapiens 0-9 30548041-5 2019 In addition, BCX, R-limonene, and R-limonene metabolites were found to enhance IFN-gamma production in KHYG-1 cells, a human NK cell line. Beta-Cryptoxanthin 13-16 interferon gamma Homo sapiens 79-88 30548041-5 2019 In addition, BCX, R-limonene, and R-limonene metabolites were found to enhance IFN-gamma production in KHYG-1 cells, a human NK cell line. Limonene 18-28 interferon gamma Homo sapiens 79-88 30548041-5 2019 In addition, BCX, R-limonene, and R-limonene metabolites were found to enhance IFN-gamma production in KHYG-1 cells, a human NK cell line. Limonene 34-44 interferon gamma Homo sapiens 79-88 30601517-6 2019 The results showed that GABA supplementation improved the growth performance and modulated the intestinal immunity with inhibiting the gene expressions of IL-22, proinflammatory cytokines (IL-1 and IL-18), and Muc1, but promoted the expressions of anti-inflammatory cytokines (IFN-gamma, IL-4, and IL-10), TLR6 and MyD88. gamma-Aminobutyric Acid 24-28 interferon gamma Homo sapiens 277-286 30632580-3 2019 In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-gamma, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells. Lactulose 50-59 interferon gamma Homo sapiens 99-108 30700717-4 2019 Inhibition of the cholesterol biosynthesis pathway with atorvastatin or 25-hydroxycholesterol during switching from IFNgamma+ to IL-10+ shows a specific block in immune resolution, defined as a significant decrease in IL-10 expression. Atorvastatin 56-68 interferon gamma Homo sapiens 116-124 30700717-4 2019 Inhibition of the cholesterol biosynthesis pathway with atorvastatin or 25-hydroxycholesterol during switching from IFNgamma+ to IL-10+ shows a specific block in immune resolution, defined as a significant decrease in IL-10 expression. 25-hydroxycholesterol 72-93 interferon gamma Homo sapiens 116-124 30626714-8 2019 Moreover, ATMP-MTX treatment stimulated CD4+ T cells to release IL-2 and CD8+ cells to release IFN-gamma. Methotrexate 15-18 interferon gamma Homo sapiens 95-104 30611297-10 2019 ROC curves showed that 66.7 pg/ml of IL-6, 20.85 pg/ml of IL-10 and 8.35 pg/ml of IFN-gamma had sensitivity and specificity for identifying KDSS as 85.2 and 62.8%; 66.7 and 83.7%; 74.1 and 74.4% respectively. kdss 140-144 interferon gamma Homo sapiens 82-91 30622742-4 2019 Surprisingly, the PAA:nanoalum adjuvant elicited a robust TH1 immune response characterized by antigen-specific CD4+ T cells expressing IFN-gamma and TNF, as well as high IgG2 titers, whereas the parent Alhydrogel and PAA elicited modest TH2 immunity characterized by IgG1 antibodies. carbopol 940 18-21 interferon gamma Homo sapiens 136-145 30670085-9 2019 Expanded DNTs have a cytotoxic phenotype, as they express NKp30, NKG2D, DNAM-1, membrane TRAIL (mTRAIL), perforin and granzyme B, and secrete IFNgamma and soluble TRAIL (sTRAIL). 2,6-dinitrotoluene 9-13 interferon gamma Homo sapiens 142-150 30687319-12 2018 The development of ADA is associated with the early impairment of IL-10 and low levels of the IL-10/IFN-gamma ratio. N-(2-acetamido)iminodiacetic acid 19-22 interferon gamma Homo sapiens 100-109 30335498-5 2019 In contrast to TNF-alpha or IFN-gamma alone, the combination of TNF-alpha/IFN-gamma blunted the ability of fluticasone propionate (FP) to reduce expression of the chemokines CCL5 and CXCL10 despite expression of key anti-inflammatory glucocorticoid receptor target genes being largely unaffected by TNF-alpha/IFN-gamma. Fluticasone 107-129 interferon gamma Homo sapiens 74-83 30335498-5 2019 In contrast to TNF-alpha or IFN-gamma alone, the combination of TNF-alpha/IFN-gamma blunted the ability of fluticasone propionate (FP) to reduce expression of the chemokines CCL5 and CXCL10 despite expression of key anti-inflammatory glucocorticoid receptor target genes being largely unaffected by TNF-alpha/IFN-gamma. Fluticasone 107-129 interferon gamma Homo sapiens 74-83 30335498-5 2019 In contrast to TNF-alpha or IFN-gamma alone, the combination of TNF-alpha/IFN-gamma blunted the ability of fluticasone propionate (FP) to reduce expression of the chemokines CCL5 and CXCL10 despite expression of key anti-inflammatory glucocorticoid receptor target genes being largely unaffected by TNF-alpha/IFN-gamma. Fluticasone 131-133 interferon gamma Homo sapiens 74-83 30335498-5 2019 In contrast to TNF-alpha or IFN-gamma alone, the combination of TNF-alpha/IFN-gamma blunted the ability of fluticasone propionate (FP) to reduce expression of the chemokines CCL5 and CXCL10 despite expression of key anti-inflammatory glucocorticoid receptor target genes being largely unaffected by TNF-alpha/IFN-gamma. Fluticasone 131-133 interferon gamma Homo sapiens 74-83 31132974-3 2019 METHODS: This in vitro study was conducted to evaluate IFN-gamma production by human whole blood stimulated with heat-treated and/or cation-supplemented phytohemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), using QuantiFERON-TB Gold Kit ELISA tests. quantiferon 236-247 interferon gamma Homo sapiens 55-64 30682445-17 2019 IFN-y ELISPOT T-cell activation responses to PA20204 were observed in both arms, but were more robust in the Arm A (p = 0.028). pa20204 45-52 interferon gamma Homo sapiens 0-5 29464523-9 2019 On treatment with methotrexate, there was a significant (p = 0.04) decline in CD8+IFNgamma+ cells from 37.2 (IQR 19.4-60.2) to 22.7% (IQR 8.5-49.7) and a marginal increase in CD8+IL17+ cells from 0.3 (IQR 0.1-0.6) to 0.4 (IQR 0.2-1.2), p = 0.006. Methotrexate 18-30 interferon gamma Homo sapiens 82-90 30444200-8 2019 Consistent with the enhanced target killing function, the 153z CARTs produced increased amount of effector cytokines including IFN-gamma, TNFalpha and IL-2 upon interaction with the target cells. 153z 58-62 interferon gamma Homo sapiens 127-136 31132974-3 2019 METHODS: This in vitro study was conducted to evaluate IFN-gamma production by human whole blood stimulated with heat-treated and/or cation-supplemented phytohemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), using QuantiFERON-TB Gold Kit ELISA tests. tb gold 248-255 interferon gamma Homo sapiens 55-64 31132974-10 2019 We found that calcium supplementation improved the PWM-induced production of IFN-gamma. Calcium 14-21 interferon gamma Homo sapiens 77-86 31141802-4 2019 In this study, we investigated the role of Sirt1 in the regulation of IFNgamma in patients with SAA. saa 96-99 interferon gamma Homo sapiens 70-78 31141802-5 2019 A significant decrease in relative SIRT1 (p< 0.05) and increase in IFNG (p< 0.05) expression levels was observed in the sorted CD8+T cells of SAA patients compared to the controls. saa 148-151 interferon gamma Homo sapiens 70-74 31141802-6 2019 There was a significant negative correlation (r = -0.53, p < 0.05) between SIRT1 and IFNG expression in SAA patients. saa 107-110 interferon gamma Homo sapiens 88-92 31141802-8 2019 In conclusion, the defective Sirt1 may be correlated to the abnormal IFNgamma expression in SAA patients, and activation of Sirt1 signaling may help improve the inflammatory status of SAA. saa 92-95 interferon gamma Homo sapiens 69-77 30911737-11 2019 Taken together, chronic alcohol consumption exacerbates cytomegalovirus infection via impairing non-specific and specific NK cell activation, specifically IFN-gamma and perforin production. Alcohols 24-31 interferon gamma Homo sapiens 155-164 29934047-5 2019 RESULTS: CHF6001 inhibited IFNgamma, IL-2 and IL-17, but not IL-13, secretion from both mild and moderate asthma patient BAL cells; there was a greater effect on IFNgamma and IL-2 than IL-17. 3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide 9-16 interferon gamma Homo sapiens 27-35 29934047-5 2019 RESULTS: CHF6001 inhibited IFNgamma, IL-2 and IL-17, but not IL-13, secretion from both mild and moderate asthma patient BAL cells; there was a greater effect on IFNgamma and IL-2 than IL-17. 3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide 9-16 interferon gamma Homo sapiens 162-170 29934047-7 2019 CHF6001 had a greater inhibitory effect on IFNgamma and IL-2 than 17-BMP. 3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide 0-7 interferon gamma Homo sapiens 43-51 31235122-6 2019 Glycemic control, most treated diabetic patients with metformin mono- and dual therapies showed an ameliorative effect in HbA1c, IFN-gamma, MPV, and PDW values compared to recent diabetic ones. Metformin 54-63 interferon gamma Homo sapiens 129-138 32440368-3 2019 Serum histidine is also inversely correlated with proinflammatory cytokines (e.g., TNF, IFN-y), which have been linked to MS fatigue. Histidine 6-15 interferon gamma Homo sapiens 88-93 30612129-4 2019 The DNA methylation patterns of the IFN-gamma promoter regions in CD4+ cells were analyzed using bisulfite sequencing. hydrogen sulfite 97-106 interferon gamma Homo sapiens 36-45 30827273-9 2019 RESULTS: Glucose stimulates interferon gamma expression and activates Janus kinase 2/signal transducers and activators of transcription 4 signaling pathway in Jurkat E6-1 cells in a concentration and timedependent manner. Glucose 9-16 interferon gamma Homo sapiens 28-44 30827273-13 2019 CONCLUSION: Liraglutide inhibits Jurkat E6-1 cells to produce interferon gamma via the Janus kinase/signal transducers and activators of transcription signaling pathway under high glucose condition, which implies its potential in the immunoregulatory effect of type 1 diabetes. Glucose 180-187 interferon gamma Homo sapiens 62-78 30487174-7 2019 Neutrophils from CVID patients actively suppressed T cell activation and release of IFN-gamma via the production of reactive oxygen species. Reactive Oxygen Species 116-139 interferon gamma Homo sapiens 84-93 30745835-7 2019 Ultimately, co-culture of sorted IFN-gamma-producing B220+Thy1.2+ IL-15-DBMCs with Mtb-infected macrophages resulted in control of the intracellular growth of Mtb via the IFN-gamma-nitric oxide axis in a donor cell number-dependent manner. Nitric Oxide 181-193 interferon gamma Homo sapiens 33-42 30642538-12 2019 Mostly IFN-gamma and its related gene sets were significantly changed (FDR < 0.25, GSEA). gsea 86-90 interferon gamma Homo sapiens 7-16 30745835-7 2019 Ultimately, co-culture of sorted IFN-gamma-producing B220+Thy1.2+ IL-15-DBMCs with Mtb-infected macrophages resulted in control of the intracellular growth of Mtb via the IFN-gamma-nitric oxide axis in a donor cell number-dependent manner. Nitric Oxide 181-193 interferon gamma Homo sapiens 171-180 30663507-3 2019 The data showed that such RA forms of Abs are able to modulate the antibody interaction with interferon gamma, and it was suggested that the observed influence of RA forms of Abs on "antibody-antigen" interaction could be used to analyze the activity of this kind of drugs. Radium 26-28 interferon gamma Homo sapiens 93-109 30663507-3 2019 The data showed that such RA forms of Abs are able to modulate the antibody interaction with interferon gamma, and it was suggested that the observed influence of RA forms of Abs on "antibody-antigen" interaction could be used to analyze the activity of this kind of drugs. Radium 163-165 interferon gamma Homo sapiens 93-109 30308300-6 2019 In addition, the Dox + IL-36gamma/POEG-st-Pmor not only could bring improved anti-metastatic effect but synergistically enhance the type I immune response by increasing the IFN-gamma positive CD4+ and CD8+ T cells and simultaneously decreasing the immunosuppressive myeloid-derived suppressor cells in the lung. Doxorubicin 17-20 interferon gamma Homo sapiens 173-182 30293884-9 2019 Interferon (IFN)-gamma concentrations in peripheral blood also diminished significantly with tacrolimus (P<0.01). Tacrolimus 93-103 interferon gamma Homo sapiens 0-22 30521981-5 2019 This notion is further supported by Actinomycin D chase experiments showing that IFNgamma-stimulated up-regulation of MLKL is prevented in the presence of the transcriptional inhibitor Actinomycin D. Dactinomycin 36-49 interferon gamma Homo sapiens 81-89 30521981-5 2019 This notion is further supported by Actinomycin D chase experiments showing that IFNgamma-stimulated up-regulation of MLKL is prevented in the presence of the transcriptional inhibitor Actinomycin D. Dactinomycin 185-198 interferon gamma Homo sapiens 81-89 30402883-8 2019 Therefore, it appears that perturbation in iron homoeostasis has essential role in HLA-DR mediated antigen presentation and innate armoury by downregulating iNOS as well as altering IFN-gamma, IL-6 and IL-10 profiles. Iron 43-47 interferon gamma Homo sapiens 182-191 30439686-0 2019 Enhanced mitochondrial pyruvate transport elicits a robust ROS production to sensitize the antitumor efficacy of interferon-gamma in colon cancer. Pyruvic Acid 23-31 interferon gamma Homo sapiens 113-129 30439686-0 2019 Enhanced mitochondrial pyruvate transport elicits a robust ROS production to sensitize the antitumor efficacy of interferon-gamma in colon cancer. Reactive Oxygen Species 59-62 interferon gamma Homo sapiens 113-129 30439686-5 2019 Forced overexpression of MPC promote the production of reactive oxygen species and enhance the apoptosis induced by IFNgamma in colon cancer cells. 2-methacryloyloxyethyl phosphorylcholine 25-28 interferon gamma Homo sapiens 116-124 30893526-0 2019 [Influence of ingaron on the dynamics of interferon-alpha and -gamma production and on the manifestation of clinical symptoms in patients with chronic virus Ersthtein-Barr infection.] ingaron 14-21 interferon gamma Homo sapiens 41-68 31484895-4 2019 The Jak1/2 inhibitor ruxolitinib can simultaneously inhibit the signaling pathway of multiple cytokines with relevance for GvHD, such as interferon (IFN-gamma), IL-2, and IL-6. ruxolitinib 21-32 interferon gamma Homo sapiens 149-158 30687765-0 2018 Intravenous Cyclophosphamide Therapy for Anti-IFN-Gamma Autoantibody-Associated Mycobacterium abscessus Infection. Cyclophosphamide 12-28 interferon gamma Homo sapiens 46-55 30272389-6 2019 IFN-gamma exposure also inhibited mitochondrial electron transport activity, and the accumulation of mitochondrial reactive oxygen species plays an important signaling role in this metabolic reconfiguration. Reactive Oxygen Species 115-138 interferon gamma Homo sapiens 0-9 30893526-3 2019 OBJECTIVES: The aim of the study is to study the effect of Ingaron therapy on the dynamics of IFN-alpha and IFN-gamma production and the clinical picture in patients with chronic Epstein-Barr virus infection (ChEBVI). ingaron 59-66 interferon gamma Homo sapiens 108-117 30893526-10 2019 RESULTS: It was shown that the content of IFN-gamma decreased (P = 0.013) after Ingaron therapy in patients with initially high levels of induced IFN-gamma (4435.64 +- 1343.50 pg/ml). ingaron 80-87 interferon gamma Homo sapiens 42-51 30893526-10 2019 RESULTS: It was shown that the content of IFN-gamma decreased (P = 0.013) after Ingaron therapy in patients with initially high levels of induced IFN-gamma (4435.64 +- 1343.50 pg/ml). ingaron 80-87 interferon gamma Homo sapiens 146-155 30893526-12 2019 Ingaron leads to an increase in spontaneous and serum IFN-gamma production in patients. ingaron 0-7 interferon gamma Homo sapiens 54-63 30576387-11 2018 SRM1649b PAH mixtures enhanced Th17 differentiation in an AHR-dependent but CYP-independent manner and increased the percent of IFNgamma positive DCs. Polycyclic Aromatic Hydrocarbons 9-12 interferon gamma Homo sapiens 128-136 30662368-8 2018 Significant changes were observed in fluoxetine treatment compared to baseline: proinflammatory cytokines IFN-gamma, IL-1beta, TNF-alpha, IL-6, IL-12, and IL-15 were decreased only at week 4 whereas IL-2 was increased only at week 8; anti-inflammatory cytokines IL-4 and IL-5 were increased at week 8 while IL-1Ra was reduced only at week 4. Fluoxetine 37-47 interferon gamma Homo sapiens 106-115 30558329-2 2018 Epigallocatechin-3-gallate (EGCG) specifically inhibits IFN-gamma pathways and unlike Janus Kinase 1 and 2 (JAK1/JAK2) inhibitors (tofacitinib, ruxolitinib), EGCG is safer, more cost-effective, and is a topically active agent. epigallocatechin gallate 0-26 interferon gamma Homo sapiens 56-65 30558329-2 2018 Epigallocatechin-3-gallate (EGCG) specifically inhibits IFN-gamma pathways and unlike Janus Kinase 1 and 2 (JAK1/JAK2) inhibitors (tofacitinib, ruxolitinib), EGCG is safer, more cost-effective, and is a topically active agent. epigallocatechin gallate 28-32 interferon gamma Homo sapiens 56-65 30558329-10 2018 However, CD8+ cells with positive Natural killer group 2 member D (NKG2D) transmembrane receptor (CD8+ NKG2D+ subset) was significantly reduced when PBMCs were treated with 20 mum EGCG for 48 h. CONCLUSION: These results suggest that EGCG has a synergistic action that inhibits expression of HLA-DR and HLA-B molecules via the IFN-gamma pathway to maintain immune privilege in HF; also it reduces CD8+ NKG2D+ subset. epigallocatechin gallate 180-184 interferon gamma Homo sapiens 327-336 30619249-9 2018 Firstly, butyrate decreases STAT1 expression leading to the inhibition of the IFNgamma-dependent and phosphoSTAT1-driven transcription of IDO-1. Butyrates 9-17 interferon gamma Homo sapiens 78-86 30647536-4 2018 Moreover, propofol treatment downregulated the production of the proinflammatory cytokines interleukin-6, tumor necrosis factor, and interferon gamma in lipopolysaccharide-stimulated macrophages by enhancing ABCA1 expression. Propofol 10-18 interferon gamma Homo sapiens 133-149 30544839-5 2018 Recent studies have confirmed that the kynurenine metabolic pathway (KP) can be stimulated by interferon-gamma (IFN-gamma) and other cytokines, activating indoleamine 2,3-dioxygenase (IDO) in SS. Kynurenine 39-49 interferon gamma Homo sapiens 94-110 30544839-5 2018 Recent studies have confirmed that the kynurenine metabolic pathway (KP) can be stimulated by interferon-gamma (IFN-gamma) and other cytokines, activating indoleamine 2,3-dioxygenase (IDO) in SS. Kynurenine 39-49 interferon gamma Homo sapiens 112-121 30564243-6 2018 In vitro study shows that IL-33 promotes the expression of IFN-gamma by Gag stimulated CD4+ and CD8+T cells from HIV-infected patients to a certain extent. Glycosaminoglycans 72-75 interferon gamma Homo sapiens 59-68 30518683-5 2018 Evaluation of tumor infiltrates and draining lymph nodes after ICB revealed expansion of IFN-gamma-producing CD4+ T cells. indole-2-carboxylic acid 63-66 interferon gamma Homo sapiens 89-98 30559742-7 2018 All identified DTGs were found to directly or indirectly inhibit IFN-gamma production or Th1 differentiation. dolutegravir 15-19 interferon gamma Homo sapiens 65-74 30352245-0 2018 Effect of continuous feeding of CO2 and pH in cell concentration and product titers in hIFNgamma producing HEK293 cells: Induced metabolic shift for concomitant consumption of glucose and lactate. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 32-35 interferon gamma Homo sapiens 87-96 30352245-0 2018 Effect of continuous feeding of CO2 and pH in cell concentration and product titers in hIFNgamma producing HEK293 cells: Induced metabolic shift for concomitant consumption of glucose and lactate. Glucose 176-183 interferon gamma Homo sapiens 87-96 30352245-0 2018 Effect of continuous feeding of CO2 and pH in cell concentration and product titers in hIFNgamma producing HEK293 cells: Induced metabolic shift for concomitant consumption of glucose and lactate. Lactic Acid 188-195 interferon gamma Homo sapiens 87-96 30559742-8 2018 We hypothesize that the absolute need for DTG to control potentially lethal IFN-gamma PRG activity leads to T. cruzi persistence and establishment of chronic infection. dolutegravir 42-45 interferon gamma Homo sapiens 76-85 29183161-3 2018 The effects of curcumin-encapsulated HA-PLA NPs on the viability of LPS/IFN-gamma stimulated peritoneal macrophages were determined using MTT assay. Curcumin 15-23 interferon gamma Homo sapiens 72-81 29183161-8 2018 The change in macrophage phenotype by curcumin-encapsulated HA-PLA NPs could suppress the inflammation in LPS/IFN-gamma stimulated macrophages as evidenced by a major reduction in pro-inflammatory cytokines. Curcumin 38-46 interferon gamma Homo sapiens 110-119 30488211-2 2018 Combined treatment with levofloxacin and vaccinal BCG strain suppressed the production of TNFalpha in drug-resistant pulmonary tuberculosis and production of IL-12 and IFNgamma in drug-sensitive tuberculosis. Levofloxacin 24-36 interferon gamma Homo sapiens 168-176 30115376-6 2018 JNK activation in cells stimulated with LPS/IFN-gamma was significantly potentiated by the two different p38 inhibitors, SB203580 and RWJ67657, suggesting the negative regulation of JNK activation by p38 in HPMVECs. SB 203580 121-129 interferon gamma Homo sapiens 44-53 30510164-10 2018 Interferon-gamma(IFN-gamma), tumor necrosis factor-alpha(TNF-alpha), and IL-10 levels were also reduced following midostaurin treatment. midostaurin 114-125 interferon gamma Homo sapiens 0-16 30510164-10 2018 Interferon-gamma(IFN-gamma), tumor necrosis factor-alpha(TNF-alpha), and IL-10 levels were also reduced following midostaurin treatment. midostaurin 114-125 interferon gamma Homo sapiens 17-26 30593739-9 2018 RESULTS: The PBG treated group of T-lymphocytes cocultured with the HuDCs pulsed by the HPV16-E7 proteins showed significantly higher numbers of T-lymphocytes and IFN-gamma release compared with T-lymphocytes without PBG in vitro. pbg 13-16 interferon gamma Homo sapiens 163-172 30374130-3 2018 Here, we identify an imbalance between the cytokines IFN-gamma and IL-10 as a shared Treg signature present in patients with multiple sclerosis and under high-salt conditions. Salts 159-163 interferon gamma Homo sapiens 53-62 30232146-3 2018 IDO1 is induced in response to inflammatory stimuli such as IFNgamma and promotes immune tolerance by depleting tryptophan and producing tryptophan catabolites, including kynurenine, in the tumor microenvironment. Tryptophan 112-122 interferon gamma Homo sapiens 60-68 30232146-3 2018 IDO1 is induced in response to inflammatory stimuli such as IFNgamma and promotes immune tolerance by depleting tryptophan and producing tryptophan catabolites, including kynurenine, in the tumor microenvironment. Kynurenine 171-181 interferon gamma Homo sapiens 60-68 30722122-9 2018 Zoledronate-treated OSCC cell lines induced IFNgamma expression in Vgamma9Vdelta2 T cells. Zoledronic Acid 0-11 interferon gamma Homo sapiens 44-52 30584406-1 2018 Background: An increase in neopterin concentrations is known in some pathologies due to interferon-gamma (INF-gamma) activation. Neopterin 27-36 interferon gamma Homo sapiens 88-104 30584406-1 2018 Background: An increase in neopterin concentrations is known in some pathologies due to interferon-gamma (INF-gamma) activation. Neopterin 27-36 interferon gamma Homo sapiens 106-115 30374130-6 2018 Moreover, we identified prostaglandin E receptor 2 (PTGER2) as a regulator of IFN-gamma and IL-10 production under a high-salt environment, with skewed activation of the beta-catenin-SGK1-Foxo axis. Salts 122-126 interferon gamma Homo sapiens 78-87 30511181-4 2018 Our results confirm: 1) the toxic effect of H2O2 in primary thyrocytes that leads to an increase of the apoptosis, to a decrease of the proliferation, and to a slight reduction of cytokines-induced CXCL10 secretion; 2) the secretion of CXCL10 chemokine induced by IFN-gamma + tumor necrosis factor alpha (TNF)-alpha has been decreased by Myo + Ins, both in presence or absence of H2O2; 3) no effect has been shown by the treatment with Se. Hydrogen Peroxide 44-48 interferon gamma Homo sapiens 264-273 30128502-15 2018 Of note, PVX-410 was immunogenic as monotherapy (10 of 11 patients) and in combination with lenalidomide (9 of 9 patients), as demonstrated by an increase in percentage of tetramer-positive cells and IFN-gamma cells in the CD3+CD8+ cell population. pvx-410 9-16 interferon gamma Homo sapiens 200-209 30128502-15 2018 Of note, PVX-410 was immunogenic as monotherapy (10 of 11 patients) and in combination with lenalidomide (9 of 9 patients), as demonstrated by an increase in percentage of tetramer-positive cells and IFN-gamma cells in the CD3+CD8+ cell population. Lenalidomide 92-104 interferon gamma Homo sapiens 200-209 30607150-0 2018 The potential effects of hemp seed/evening primrose oils on the mammalian target of rapamycin complex 1 and interferon-gamma genes expression in experimental autoimmune encephalomyelitis. evening primrose oil 43-56 interferon gamma Homo sapiens 64-124 30051373-2 2018 Interferon-gamma is a cytokine that acts as a mediator between immune stimulation and the kynurenine pathway and may be related to cognitive abilities. Kynurenine 90-100 interferon gamma Homo sapiens 0-16 30051373-9 2018 The negative correlations between interferon-gamma and cognition in patients with schizophrenia suggest the hypothesis that inflammation and the kynurenine pathway have important roles in this disorder. Kynurenine 145-155 interferon gamma Homo sapiens 34-50 30815354-11 2019 Moreover, IMQ-induced inflammatory cytokines; Th1 cytokines (TNF-alpha, IFN-alpha, IFN-gamma,and IL-27) and Th17 cytokines (IL-17A and IL-23), in the serum and skin showed marked inhibition by hE-MSCs. Imiquimod 10-13 interferon gamma Homo sapiens 83-92 30501716-7 2018 Both IL-2 and IFN- gamma levels in the patients before the treatment were significantly higher than those in the normal control group (P<0.05), and the expression levels after treatment with dexamethasone decreased significantly. Dexamethasone 194-207 interferon gamma Homo sapiens 14-24 30501716-9 2018 CONCLUSION: The incidence of ITP patients closely relates with the level and dysfunction of DC subsets in peripheral blood and the expression levels of IL-2, IL-4, IL-10, IFN- gamma, which significantly correlates with the efficacy of dexamethasone. Dexamethasone 235-248 interferon gamma Homo sapiens 171-181 30346692-6 2018 In the primary mixed-cell population, USSN induced IFN-gamma secretion but failed to induce T-cell proliferation or the secretion of IL-2, IL-10, or IL-4. ussn 38-42 interferon gamma Homo sapiens 51-60 30470234-10 2018 Neopterin, a marker of IFN-gamma activity, was associated with an unfavorable balance between neuroprotective and neurotoxic tryptophan metabolites. Neopterin 0-9 interferon gamma Homo sapiens 23-32 30470234-10 2018 Neopterin, a marker of IFN-gamma activity, was associated with an unfavorable balance between neuroprotective and neurotoxic tryptophan metabolites. Tryptophan 125-135 interferon gamma Homo sapiens 23-32 30470234-12 2018 IFN-gamma activity, assessed by neopterin and IP-10 levels, may play a role in the activation of the KP pathway in these patients, potentially mediating neurotoxic effects. Neopterin 32-41 interferon gamma Homo sapiens 0-9 30305327-7 2018 In antimelanoma tumor-infiltrating lymphocytes (TILs), caCD40 induced massive production of IFN-gamma, exerting a pronounced synergistic effect when coexpressed with constitutively active TLR4 devoid of its extracellular ligand binding. cacd40 55-61 interferon gamma Homo sapiens 92-101 30524966-6 2018 In overnight cytokine release assays in which CAR T cells were challenged with the CD33+ tumor cells HL-60, MOLM-14 and KG-1a, CAR33VH elicited IFN-gamma, TNF-alpha and IL-2. car33vh 127-134 interferon gamma Homo sapiens 144-153 30486590-7 2018 After blocking SLAMF6 pathway by anti-SLAMF6 Ab, the expression levels of perforin, granzyme B and IFN-gamma in SAA patients were significantly higher than those in the untreated group, and the differences were statistically significant (all P<0.05). saa 112-115 interferon gamma Homo sapiens 99-108 30159779-8 2018 Among IDH1wild type (WT) TERTMT patients, DCV treatment significantly prolonged OS (p < 0.01) and PFS (p = 0.03) and increased plasma levels of cytokines CCL22 and IFN-gamma compared with placebo. DyeCycle Violet 42-45 interferon gamma Homo sapiens 167-176 30427403-6 2018 The presence of DPC in individuals with LR immunoregulated IL-6, IFN-gamma, and IL-4 concentrations. dpc 16-19 interferon gamma Homo sapiens 65-74 30242834-5 2018 Our results demonstrate that dasatinib impaired proliferation, cytokine release (IFN-gamma, TNF-alpha, GM-CSF), expression of granulysin and degranulation of cytotoxic effector molecules of human Mtb-specific T-lymphocytes by inhibition of lymphocyte-specific protein tyrosine kinase (Lck) phosphorylation. Dasatinib 29-38 interferon gamma Homo sapiens 81-90 30348823-3 2018 When human islets were exposed to inflammatory stress induced by interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma, arginine residue R510 within GRP78 was converted into citrulline, as evidenced by liquid chromatography-tandem mass spectrometry. Arginine 135-143 interferon gamma Homo sapiens 117-133 30348823-3 2018 When human islets were exposed to inflammatory stress induced by interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma, arginine residue R510 within GRP78 was converted into citrulline, as evidenced by liquid chromatography-tandem mass spectrometry. Citrulline 189-199 interferon gamma Homo sapiens 117-133 30455079-13 2018 Additionally, IL-10, interferon (IFN)-gamma, and FMS-like tyrosine kinase 3 ligand (Flt-3L) extracellular output was significantly decreased at 100 nM EB1089 and intracellular IL-10 was decreased with either calcitriol or EB1089 treatment. seocalcitol 151-157 interferon gamma Homo sapiens 21-43 29972690-8 2018 At a cellular level, PBMC from asymptomatic and cardiac patients proliferated and secreted interferon-gamma after c-TXNPx stimulation, compared with mock control. c-txnpx 114-121 interferon gamma Homo sapiens 91-107 30261195-7 2018 Citomix was able to significantly increase the expression of B memory cells, IFN-gamma, IL-6, IgA and IgM, and significantly decrease IL-10 and IgG. citomix 0-7 interferon gamma Homo sapiens 77-86 30144640-6 2018 Sesamolin also increased the expression of the degranulation marker, CD107a, on the surface of NK cells and the production of immune-activation cytokine, IFN-gamma, from NK cells. sesamolin 0-9 interferon gamma Homo sapiens 154-163 30025621-4 2018 CDDO-DFPA-induced Nrf2 activation resulted in a TolDC phenotype as evidenced by induction of IL-4, IL-10, and TGF-beta and suppression of TNFalpha, IFN-gamma, and IL-12 levels in Nrf2+/+ but not Nrf2-/- DCs. cddo-dfpa 0-9 interferon gamma Homo sapiens 148-157 30061014-9 2018 Inhibition of mTORC1 pathway with rapamycin, increase Tregs and decrease effector CD4+IFNgamma+, CD4+IL17+ and CD4+IL21+ T cells in patients with LVV. Sirolimus 34-43 interferon gamma Homo sapiens 86-94 29957091-6 2018 Curcumin interacts with receptors, growth and transcription factors, cytokines, enzymes, and genes leading to inhibitory effects on cyclooxygenase-1, tumor necrosis factor-alpha, interferon-gamma, inducible nitric oxide synthase, transcriptional nuclear factor kappa B, and many other molecules associated with inflammatory processes. Curcumin 0-8 interferon gamma Homo sapiens 179-228 30276549-11 2018 ELISA analysis showed that aspirin significantly decreased the production of inflammatory cytokines IFN-gamma (p value < 0.05) and IL-8 (p value < 0.001) in PE-DMSCs. Aspirin 27-34 interferon gamma Homo sapiens 100-109 30276549-11 2018 ELISA analysis showed that aspirin significantly decreased the production of inflammatory cytokines IFN-gamma (p value < 0.05) and IL-8 (p value < 0.001) in PE-DMSCs. dmscs 166-171 interferon gamma Homo sapiens 100-109 30425720-5 2018 NK cells were shown to be hyper-responsive to adenosine when primed with IL-12 and IL-15 compared to IL-2, exhibiting enhanced IFN-gamma expression from CD56bright and CD56dim subsets while modulating the expression of activation marker NKG2D. Adenosine 46-55 interferon gamma Homo sapiens 127-136 29888839-10 2018 A functional restoration of CD56bright NK cells in entecavir-treated patients who were switched to PegIFNalpha contributes to HBsAg and cccDNA clearance through TRAIL-induced cytolysis and TNF-alpha/IFNgamma-mediated noncytolytic pathways. entecavir 51-60 interferon gamma Homo sapiens 199-207 29888839-10 2018 A functional restoration of CD56bright NK cells in entecavir-treated patients who were switched to PegIFNalpha contributes to HBsAg and cccDNA clearance through TRAIL-induced cytolysis and TNF-alpha/IFNgamma-mediated noncytolytic pathways. pegifnalpha 99-110 interferon gamma Homo sapiens 199-207 30116000-4 2018 ONO-4641-expanded CD11b+Gr-1+ cells showed higher arginase-1 activity, decreased T cell proliferation, and lower IFN-gamma production in CD3+ T cells, similar to the features of myeloid-derived suppressor cells. ceralifimod 0-8 interferon gamma Homo sapiens 113-122 30426024-7 2018 Secreted production of IFN-gamma stimulated via CD3 decreased by CH exposure at 30 mug/ml, although the percentage of IFN-gamma + cells induced by PMA/ionomycin did not decrease. Tetradecanoylphorbol Acetate 147-150 interferon gamma Homo sapiens 118-127 30426024-7 2018 Secreted production of IFN-gamma stimulated via CD3 decreased by CH exposure at 30 mug/ml, although the percentage of IFN-gamma + cells induced by PMA/ionomycin did not decrease. Ionomycin 151-160 interferon gamma Homo sapiens 118-127 30104241-7 2018 Gene expression analysis of tumor samples from patients with ovarian cancer before and after treatment with paclitaxel detected an enrichment of genes linked to the M1 macrophage activation profile (IFNgamma-stimulated macrophages). Paclitaxel 108-118 interferon gamma Homo sapiens 199-207 30425515-6 2018 IFN-gamma production by T cells was decreased in a glucose-free medium and severely decreased when cells were simultaneously deprived of glutamine. Glucose 51-58 interferon gamma Homo sapiens 0-9 30425515-6 2018 IFN-gamma production by T cells was decreased in a glucose-free medium and severely decreased when cells were simultaneously deprived of glutamine. Glutamine 137-146 interferon gamma Homo sapiens 0-9 30425515-10 2018 Our data also show that inhibiting glutamine metabolism in bladder cancer cells could reduce the elevation in PD-L1 expression induced by IFN-gamma. Glutamine 35-44 interferon gamma Homo sapiens 138-147 30179004-3 2018 Cloned CD8+ T-cells proliferated and secreted IFN-gamma in the presence of ticlopidine and autologous antigen presenting cells. Ticlopidine 75-86 interferon gamma Homo sapiens 46-55 30386344-5 2018 Our results demonstrate that peripheral dopamine controlled by gut microbes inhibits IL4 and IFNgamma production in iNKT cells and suppresses iNKT cell-mediated hepatitis. Dopamine 40-48 interferon gamma Homo sapiens 93-101 30266819-6 2018 In addition, increasing immunoproteasome expression by interferon-gamma increases sensitivity to ONX-0914 but not to carfilzomib. PR-957 97-105 interferon gamma Homo sapiens 55-71 30300579-3 2018 Therapeutic inhibition of C5aR1 via the peptide antagonist PMX-53 improved efficacy of paclitaxel chemotherapy associated with increased presence and cytotoxic properties of CXCR3+ effector memory CD8+ T cells in carcinomas, dependent on both macrophage transcriptional programming and IFNgamma. AcPhe(ornithine-Pro-cyclohexylamine-Trp-Arg) 59-65 interferon gamma Homo sapiens 286-294 30279388-1 2018 Polyphenols Modulate Interferon Gamma/Histamine-Induced Inflammation in Human NCTC 2544 Keratinocytes. Polyphenols 0-11 interferon gamma Homo sapiens 21-37 30135206-5 2018 The mechanism consists of an IFN-induced, Bcl3- and p300-dependent PD-L1 promoter occupancy by Lys-314/315 acetylated p65 NF-kappaB. Lysine 95-98 interferon gamma Homo sapiens 29-32 30301383-1 2018 OBJECTIVE: Neopterin is a pteridine that is produced following activation of human macrophages upon stimulation with the cytokine interferon-gamma. Neopterin 11-20 interferon gamma Homo sapiens 130-146 30301383-1 2018 OBJECTIVE: Neopterin is a pteridine that is produced following activation of human macrophages upon stimulation with the cytokine interferon-gamma. Pteridines 26-35 interferon gamma Homo sapiens 130-146 30333797-9 2018 CPA patients did not differ significantly in the BALF cytokine profile compared to patients with respiratory disorders without CPA, but showed significant higher values for IFN-gamma, IL-1b, IL-6, IL-8, and TNF-alpha compared to healthy individuals. cpa 0-3 interferon gamma Homo sapiens 173-182 30142362-6 2018 Higher release of IL-1alpha, IL-1beta, IFN-gamma, IL-12p70 and TNF-alpha and a reduced IL-10 secretion after lipopolysaccharide (LPS) stimulation were observed in PBMCs from Arg/Arg T2DM carriers as compared to subjects with the Trp variant. Arginine 174-177 interferon gamma Homo sapiens 39-48 30007645-2 2018 IDO expression and kynurenine production from LSP-treated HepG2 cells following IFN-gamma stimulation were dramatically inhibited by LSP treatment. Kynurenine 19-29 interferon gamma Homo sapiens 80-89 30007645-4 2018 Moreover, tyrosine 701 and serine 727 phosphorylation of STAT1 were dramatically reduced by LSP pretreatment in IFN-gamma-stimulated HepG2 cells. Tyrosine 10-18 interferon gamma Homo sapiens 112-121 30007645-4 2018 Moreover, tyrosine 701 and serine 727 phosphorylation of STAT1 were dramatically reduced by LSP pretreatment in IFN-gamma-stimulated HepG2 cells. Serine 27-33 interferon gamma Homo sapiens 112-121 30402489-5 2018 LDL-cholesterol levels (i) positively correlated with IL-6, IFN-gamma, E-selectin, sCD-40L, 8-OH-2"-deoxyguanosine, platelet aggregation to ADP, collagen, AA, and aspirin IC-50 and (ii) negatively correlated with IL-10 and sRAGE. Cholesterol 4-15 interferon gamma Homo sapiens 60-69 30118696-7 2018 TGF-beta1-induced upregulation of Cx43 was mediated by TGFbetaRI (ALK5) and SMAD2/3 signaling, and this was potently suppressed by PGE2, IL-1beta, TNF-alpha and IFN-gamma that inhibited SMAD2/3 phosphorylation. Dinoprostone 131-135 interferon gamma Homo sapiens 161-170 30003405-12 2018 The levels of IL-4, IL-10, and IFN-gamma decreased after treatment with both dexamethasone and GA, but the ratio of IFN-gamma/IL-4 (Th1/Th2 balance) increased significantly due to 200 muM GA treatment. Dexamethasone 77-90 interferon gamma Homo sapiens 31-40 30104242-7 2018 Gene expression profiling of pretreatment and on-treatment lymph node biopsy specimens revealed upregulation of IFN-gamma and many of its target genes in response to lenalidomide. Lenalidomide 166-178 interferon gamma Homo sapiens 112-121 29879374-4 2018 We found that OEA, PEA, and eicosatrienoyl ethanolamide (ETEA) could directly inhibit both T-cell responses by reducing their production of TNF-alpha and IFN-gamma from CD8 T cells and TNF-alpha, IFN-gamma and IL-17 from CD4 T cells. oleoylethanolamide 14-17 interferon gamma Homo sapiens 196-205 29879374-4 2018 We found that OEA, PEA, and eicosatrienoyl ethanolamide (ETEA) could directly inhibit both T-cell responses by reducing their production of TNF-alpha and IFN-gamma from CD8 T cells and TNF-alpha, IFN-gamma and IL-17 from CD4 T cells. palmidrol 19-22 interferon gamma Homo sapiens 154-163 29879374-4 2018 We found that OEA, PEA, and eicosatrienoyl ethanolamide (ETEA) could directly inhibit both T-cell responses by reducing their production of TNF-alpha and IFN-gamma from CD8 T cells and TNF-alpha, IFN-gamma and IL-17 from CD4 T cells. palmidrol 19-22 interferon gamma Homo sapiens 196-205 29879374-4 2018 We found that OEA, PEA, and eicosatrienoyl ethanolamide (ETEA) could directly inhibit both T-cell responses by reducing their production of TNF-alpha and IFN-gamma from CD8 T cells and TNF-alpha, IFN-gamma and IL-17 from CD4 T cells. eicosatrienoyl ethanolamide 28-55 interferon gamma Homo sapiens 154-163 29879374-4 2018 We found that OEA, PEA, and eicosatrienoyl ethanolamide (ETEA) could directly inhibit both T-cell responses by reducing their production of TNF-alpha and IFN-gamma from CD8 T cells and TNF-alpha, IFN-gamma and IL-17 from CD4 T cells. eicosatrienoyl ethanolamide 28-55 interferon gamma Homo sapiens 196-205 29879374-4 2018 We found that OEA, PEA, and eicosatrienoyl ethanolamide (ETEA) could directly inhibit both T-cell responses by reducing their production of TNF-alpha and IFN-gamma from CD8 T cells and TNF-alpha, IFN-gamma and IL-17 from CD4 T cells. etea 57-61 interferon gamma Homo sapiens 154-163 29879374-4 2018 We found that OEA, PEA, and eicosatrienoyl ethanolamide (ETEA) could directly inhibit both T-cell responses by reducing their production of TNF-alpha and IFN-gamma from CD8 T cells and TNF-alpha, IFN-gamma and IL-17 from CD4 T cells. etea 57-61 interferon gamma Homo sapiens 196-205 30090948-7 2018 IFNgamma decreased AQP3 mRNA expression in HT-29 cells in a time- and concentration-dependent manner and reduced functional AQP3 protein expression (decreased 3H-labelled glycerol uptake). Tritium 159-161 interferon gamma Homo sapiens 0-8 30090948-7 2018 IFNgamma decreased AQP3 mRNA expression in HT-29 cells in a time- and concentration-dependent manner and reduced functional AQP3 protein expression (decreased 3H-labelled glycerol uptake). Glycerol 171-179 interferon gamma Homo sapiens 0-8 30214604-8 2018 The results from the present study revealed that the expression of IFN-gamma, interleukin (IL)-2, tumor necrosis factor-alpha and IL-12 of PBMCs from patients with LC and healthy donors were significantly increased following treatment with rMBP-NAP (P<0.05). rmbp-nap 240-248 interferon gamma Homo sapiens 67-76 30214604-9 2018 Additionally, rMBP-NAP significantly upregulated the number of IFN-gamma-secreting cells in PBMCs and prominently increased the cytotoxic activity of PBMCs (P<0.05). rmbp-nap 14-22 interferon gamma Homo sapiens 63-72 30081186-5 2018 The levels of fractalkine on day 0 and 7th day, IP-10 on 4th and 7th day, and IFN-gamma on 7th day in ARG was significantly higher than that in NRG. Arginine 102-105 interferon gamma Homo sapiens 78-87 29975662-6 2018 The synthetic molecule alpha-galactosylceramide has also been shown to stimulate natural killer cell activation and interferon (IFN)-gamma secretion. alpha-galactosylceramide 23-47 interferon gamma Homo sapiens 116-138 30258117-8 2018 Furthermore, higher acetate concentrations were also able to increase IFN-gamma production in CD8+ T lymphocytes by modulating cellular metabolism and mTOR activity. Acetates 20-27 interferon gamma Homo sapiens 70-79 29879374-4 2018 We found that OEA, PEA, and eicosatrienoyl ethanolamide (ETEA) could directly inhibit both T-cell responses by reducing their production of TNF-alpha and IFN-gamma from CD8 T cells and TNF-alpha, IFN-gamma and IL-17 from CD4 T cells. oleoylethanolamide 14-17 interferon gamma Homo sapiens 154-163 30039507-6 2018 This way we were able to show that the decrease of cerebral ACh triggers increased secretion of IL-1beta, IL-6, TNFalpha, MIP-2 (CCL3), RANTES, MCP1, IFNgamma, and IP-10. Acetylcholine 60-63 interferon gamma Homo sapiens 150-158 30019152-0 2018 Metabolic engineering of Pichia pastoris GS115 for enhanced pentose phosphate pathway (PPP) flux toward recombinant human interferon gamma (hIFN-gamma) production. Pentosephosphates 60-77 interferon gamma Homo sapiens 122-150 30019152-1 2018 In the present study, the effects of individual as well as multiple genes of pentose phosphate pathway (PPP) on human interferon gamma (hIFN-gamma) production were analyzed. Pentosephosphates 77-94 interferon gamma Homo sapiens 118-146 30019152-5 2018 In both strains (GS115/hIFN-gamma and GS115/hIFN-gamma/SR) more than 95% of formaldehyde flux is directed towards assimilatory pathway. Formaldehyde 76-88 interferon gamma Homo sapiens 23-33 30019152-5 2018 In both strains (GS115/hIFN-gamma and GS115/hIFN-gamma/SR) more than 95% of formaldehyde flux is directed towards assimilatory pathway. Formaldehyde 76-88 interferon gamma Homo sapiens 44-54 30274279-10 2018 In addition, DPV576 inhibited the capsaicin, induced the production of IFN-gamma, and enhanced the secretion of IL-10. dpv576 13-19 interferon gamma Homo sapiens 71-80 30258117-5 2018 Increased IFN-gamma and granzyme B expression by CTLs as well as the molecular switch of Tc17 cells towards the CTL phenotype was mediated by butyrate independently of its interaction with specific SCFA-receptors GPR41 and GPR43. Butyrates 142-150 interferon gamma Homo sapiens 10-19 30294594-9 2018 Serum level of IL-10 was higher and the levels of TGF-beta, Th1 cytokines (IL-2 and IFN-gamma), and Th2 cytokines (IL-4 and IL-6) were lower in the AOS group than in the control group (P < 0.05). D-(+)-ALLOSE 148-151 interferon gamma Homo sapiens 84-93 30248098-11 2018 M. leprae antigen-specific IFN-gamma release assessed by WBA has diagnostic value for distinguishing PB from TB but not for distinguishing PB from HHC or EC. pladienolide B 101-103 interferon gamma Homo sapiens 27-36 30288187-0 2018 Losartan, but not Enalapril and Valsartan, Inhibits the Expression of IFN-gamma, IL-6, IL-17F and IL-22 in PBMCs from Rheumatoid Arthritis Patients. Losartan 0-8 interferon gamma Homo sapiens 70-79 30288187-8 2018 Results: Losartan was able to reduce levels of IFN-gamma (p = 0.0181), IL-6 (p = 0.0056), IL-17F (0.0046) and IL-22 (p = 0.0234) in RA patients. Losartan 9-17 interferon gamma Homo sapiens 47-56 30144450-6 2018 Ca levels were significantly increased in HASMCs cultured in IFN-gamma-treated medium, compared with non-IFN-gamma-treated medium in the presence of Pi (0.9-2.4 mM). hasmcs 42-48 interferon gamma Homo sapiens 61-70 30144450-7 2018 The inhibition of p38 MAPK and PKA decreased HASMC calcification stimulated by Pi and IFN-gamma-treated medium, though PKA inhibition produced a more significant reduction in calcification than p38 MAPK inhibition. hasmc 45-50 interferon gamma Homo sapiens 86-95 30223437-9 2018 We conclude that CNP downmodulates IFN-gamma induced pro-inflammatory gene expression in human endothelial cells via a cGMP-mediated pathway. Cyclic GMP 119-123 interferon gamma Homo sapiens 35-44 30208917-8 2018 However, whereas phorbol 12-myristate 13-acetate/ionomycin stimulation induced the production of both interferon-gamma and IL-17 by breast duct MAIT cells, bacterially exposed breast carcinoma cells elicited a strongly IL-17-biased response. Tetradecanoylphorbol Acetate 17-48 interferon gamma Homo sapiens 102-118 30208917-8 2018 However, whereas phorbol 12-myristate 13-acetate/ionomycin stimulation induced the production of both interferon-gamma and IL-17 by breast duct MAIT cells, bacterially exposed breast carcinoma cells elicited a strongly IL-17-biased response. Ionomycin 49-58 interferon gamma Homo sapiens 102-118 30524887-11 2018 Our data therefore suggest that the upregulation of WARS via IFNgamma and/or GCN2-peIF2alpha-ATF4 signaling protects Trp-degrading cancer cells from excessive intracellular Trp depletion. Tryptophan 173-176 interferon gamma Homo sapiens 61-69 29857000-0 2018 Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes. Thymidine 31-33 interferon gamma Homo sapiens 167-176 29857000-6 2018 In the current study, we investigated the issue of whether or how Quercetin attenuates poly (dA:dT), a synthetic analog of microbial dsDNA, -induced IL-18 secretion in IFN-gamma-primed human keratinocytes. Quercetin 66-75 interferon gamma Homo sapiens 168-177 29857000-6 2018 In the current study, we investigated the issue of whether or how Quercetin attenuates poly (dA:dT), a synthetic analog of microbial dsDNA, -induced IL-18 secretion in IFN-gamma-primed human keratinocytes. poly 87-91 interferon gamma Homo sapiens 168-177 29857000-6 2018 In the current study, we investigated the issue of whether or how Quercetin attenuates poly (dA:dT), a synthetic analog of microbial dsDNA, -induced IL-18 secretion in IFN-gamma-primed human keratinocytes. Thymidine 96-98 interferon gamma Homo sapiens 168-177 29857000-7 2018 Treatment with 5 and 10 muM of Quercetin inhibited the poly (dA:dT)-induced secretion of IL-18 after IFN-gamma priming and before poly (dA:dT)-induced AIM2 activation. Quercetin 31-40 interferon gamma Homo sapiens 101-110 29857000-7 2018 Treatment with 5 and 10 muM of Quercetin inhibited the poly (dA:dT)-induced secretion of IL-18 after IFN-gamma priming and before poly (dA:dT)-induced AIM2 activation. Poly dA-dT 55-67 interferon gamma Homo sapiens 101-110 29857000-7 2018 Treatment with 5 and 10 muM of Quercetin inhibited the poly (dA:dT)-induced secretion of IL-18 after IFN-gamma priming and before poly (dA:dT)-induced AIM2 activation. Poly dA-dT 55-66 interferon gamma Homo sapiens 101-110 29857000-8 2018 In addition, treatment with Quercetin at 10 muM, significantly inhibited the phosphorylation of JAK2 and STAT1, and the nuclear translocation of phosphorylated STAT1 in poly (dA:dT)-treated and IFN-gamma-primed keratinocytes. Quercetin 28-37 interferon gamma Homo sapiens 194-203 29857000-9 2018 These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes. Quercetin 42-51 interferon gamma Homo sapiens 210-219 29857000-9 2018 These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes. poly 65-69 interferon gamma Homo sapiens 210-219 29857000-9 2018 These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes. amsonic acid 71-73 interferon gamma Homo sapiens 210-219 29857000-9 2018 These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes. Thymidine 74-76 interferon gamma Homo sapiens 210-219 29909345-8 2018 Furthermore, macrophage phenotype switching by PLGA-PEG encapsulated Chr NPs significantly suppressed LPS/IFN-gamma induced inflammation by a remarkable reduction in pro-inflammatory cytokine levels, TNF-alpha, IL-1beta, and IL-6. Polyethylene Glycols 52-55 interferon gamma Homo sapiens 106-115 29978334-10 2018 Taken together, our data show that MEDI3622 enhances the release of IFNgamma by NK cells engaging antibody-bound tumor cells by blocking the shedding of CD16A. medi3622 35-43 interferon gamma Homo sapiens 68-76 29804995-5 2018 A conjugation of synthetic alpha(1,6)mannan with TT can also enhance immune response to TT in vivo after immunization as shown by an increase in TNF-alpha, IFN-gamma, and IL-2 production in splenocytes. alpha(1,6)mannan 27-43 interferon gamma Homo sapiens 156-165 30021835-8 2018 Furthermore, dimethyl fumarate, an antioxidant used for the treatment of several autoimmune diseases, impairs the IFNgamma response by manipulating transcriptional control of MHCII We describe novel pathways and drugs related to oxidative conditions in cells impacting on IFNgamma-mediated MHCII expression, which provide a molecular basis for the understanding of MHCII-associated diseases. Dimethyl Fumarate 13-30 interferon gamma Homo sapiens 114-122 30021835-8 2018 Furthermore, dimethyl fumarate, an antioxidant used for the treatment of several autoimmune diseases, impairs the IFNgamma response by manipulating transcriptional control of MHCII We describe novel pathways and drugs related to oxidative conditions in cells impacting on IFNgamma-mediated MHCII expression, which provide a molecular basis for the understanding of MHCII-associated diseases. Dimethyl Fumarate 13-30 interferon gamma Homo sapiens 272-280 29895377-8 2018 In contrast to cyclosporine A and dexamethasone, only zinc aspartate and rapamycin were capable of suppressing the proliferation and Th1 (IFN-gamma), Th2 (IL-5), and Th17 (IL-17) cytokine production of pre-activated T cells. zinc-bis(hydrogenaspartate) 54-68 interferon gamma Homo sapiens 138-147 29895377-8 2018 In contrast to cyclosporine A and dexamethasone, only zinc aspartate and rapamycin were capable of suppressing the proliferation and Th1 (IFN-gamma), Th2 (IL-5), and Th17 (IL-17) cytokine production of pre-activated T cells. Sirolimus 73-82 interferon gamma Homo sapiens 138-147 29853118-6 2018 ELISA detection confirmed a significant increase in the release of IFN-gamma, IL-2 and TNF-alpha cytokines and flow cytometry analysis revealed enhanced expression of CD3, CD8, and CD56 after treating PBL with PEC-GG-ZnO as compared to PEC and GG treatment. pec-gg-zno 210-220 interferon gamma Homo sapiens 67-76 29870142-9 2018 Aberrant cytokine profiles were secreted by SAA MSCs, with increased concentrations of interleukin-6, interferon-gamma, tumor necrosis factor-alpha, and interleukin-1beta in the CM. saa 44-47 interferon gamma Homo sapiens 102-147 30129176-5 2018 It is found that HA-Psi-DOX nanoparticles can kill tumor cells effectively and initiate an antitumor immune response, leading to the upregulation of interferon-gamma. Doxorubicin 24-27 interferon gamma Homo sapiens 149-165 30157233-7 2018 RESULTS: We found that the addition of IL-7 led to significantly higher release of IFN-gamma in individuals with active TB from 4.2IU/ml (IQR 1.4-6.9IU/ml) to 5.1IU/ml (IQR 1.5-8.1IU/ml, p = 0.0057), and we found an indication of a lower release of both IFN-gamma and IP-10 in participants with negative tests. Terbium 120-122 interferon gamma Homo sapiens 83-92 30126206-3 2018 We here report that (-)-epigallocatechin gallate (EGCG) inhibited programmed cell death ligand 1 (PD-L1) expression in non-small-cell lung cancer cells, induced by both interferon (IFN)-gamma and epidermal growth factor (EGF). epigallocatechin gallate 20-48 interferon gamma Homo sapiens 169-191 30126206-3 2018 We here report that (-)-epigallocatechin gallate (EGCG) inhibited programmed cell death ligand 1 (PD-L1) expression in non-small-cell lung cancer cells, induced by both interferon (IFN)-gamma and epidermal growth factor (EGF). epigallocatechin gallate 50-54 interferon gamma Homo sapiens 169-191 30126206-4 2018 The mRNA and protein levels of IFN-gamma-induced PD-L1 were reduced 40-80% after pretreatment with EGCG and green tea extract (GTE) in A549 cells, via inhibition of JAK2/STAT1 signaling. epigallocatechin gallate 99-103 interferon gamma Homo sapiens 31-40 30546955-4 2019 Trametinib also further upregulated the increase in CXCL9 and CXCL10 expression caused by IFN-gamma in HNSCC cells, which is associated with T cell infiltration in tumor tissues. trametinib 0-10 interferon gamma Homo sapiens 90-99 30283439-6 2018 Instead, IFN-gamma-induced tryptophan degradation by indole-2,3-dioxygenase (IDO) is important for the anti-T. gondii human response. Tryptophan 27-37 interferon gamma Homo sapiens 9-18 30223437-7 2018 IFN-gamma significantly increased expression of both molecules, which was significantly inhibited by CNP or the cGMP donor 8-Bromoguanosine 3",5"-cyclic monophosphate (1 microm). Cyclic GMP 112-116 interferon gamma Homo sapiens 0-9 30223437-7 2018 IFN-gamma significantly increased expression of both molecules, which was significantly inhibited by CNP or the cGMP donor 8-Bromoguanosine 3",5"-cyclic monophosphate (1 microm). 8-bromocyclic GMP 123-166 interferon gamma Homo sapiens 0-9 30223437-8 2018 CNP also reduced IFN-gamma mediated kynurenine generation by the IFN-gamma regulated enzyme indoleamine-2,3-deoxygenase (IDO). Kynurenine 36-46 interferon gamma Homo sapiens 17-26 30223437-8 2018 CNP also reduced IFN-gamma mediated kynurenine generation by the IFN-gamma regulated enzyme indoleamine-2,3-deoxygenase (IDO). Kynurenine 36-46 interferon gamma Homo sapiens 65-74 30254683-4 2018 Furthermore, the effect of CoCl2 is exerted by promoting the expression of anti-inflammatory mediators (e.g., PGE2) and inhibiting that of inflammatory cytokines (e.g., TNF-alpha and IFN-gamma). cobaltous chloride 27-32 interferon gamma Homo sapiens 183-192 29857000-0 2018 Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes. Quercetin 0-9 interferon gamma Homo sapiens 167-176 29857000-0 2018 Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes. poly 23-27 interferon gamma Homo sapiens 167-176 29715554-8 2018 RGP-treated MDDCs promoted upregulation of T-cell activation, including proliferation and interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) production. mddcs 12-17 interferon gamma Homo sapiens 90-106 29715554-8 2018 RGP-treated MDDCs promoted upregulation of T-cell activation, including proliferation and interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) production. mddcs 12-17 interferon gamma Homo sapiens 108-117 29976100-1 2018 Objective Alcohol is a hypnotic that modifies immune function, specifically the cytokines interferon gamma (IFN-gamma) and interleukin 2 (IL-2). Alcohols 10-17 interferon gamma Homo sapiens 90-117 29976100-2 2018 We evaluated the association between unscheduled napping and acute alcohol-induced augmentation of IFN-gamma and IL-2 expression. Alcohols 67-74 interferon gamma Homo sapiens 99-108 29976100-11 2018 Conclusion Augmented IFN-gamma and IL-2 levels are associated with unscheduled napping after binge alcohol consumption. Alcohols 99-106 interferon gamma Homo sapiens 21-30 29487385-6 2018 ACY241 induces co-stimulatory (CD28, 41BB, CD40L, OX40) and activation (CD38) molecule expression in a dose- and time-dependent manner, and anti-tumor activities, evidenced by increased perforin/CD107a expression, IFN-gamma/IL-2/TNF-alpha production, and antigen-specific central memory CTL. Citarinostat 0-6 interferon gamma Homo sapiens 214-223 30010674-1 2018 Increased tryptophan (Trp) catabolism in the tumor microenvironment (TME) can mediate immune suppression by upregulation of interferon (IFN)-gamma-inducible indoleamine 2,3-dioxygenase (IDO1) and/or ectopic expression of the predominantly liver-restricted enzyme tryptophan 2,3-dioxygenase (TDO). Tryptophan 10-20 interferon gamma Homo sapiens 124-146 30010674-1 2018 Increased tryptophan (Trp) catabolism in the tumor microenvironment (TME) can mediate immune suppression by upregulation of interferon (IFN)-gamma-inducible indoleamine 2,3-dioxygenase (IDO1) and/or ectopic expression of the predominantly liver-restricted enzyme tryptophan 2,3-dioxygenase (TDO). Tryptophan 22-25 interferon gamma Homo sapiens 124-146 30148839-9 2018 The Mycobacterium tuberculosis antigen-specific production of IFN-gamma and IP-10 on PB or PF did not show significant differences. pf 91-93 interferon gamma Homo sapiens 62-71 30148839-18 2018 The combination of IFN-gamma and ADA, in a reviewed cut-off point, showed to be particularly useful to clinicians as their positive results combined prompts immediate treatment for TB while both negative results suggest further investigation. Terbium 181-183 interferon gamma Homo sapiens 19-28 30132758-5 2018 Remarkably, a different antiviral stimulus, interferon gamma (IFN-gamma), that induces a largely non-overlapping set of genes, also transcriptionally represses CDK1, CDK2 and their associated cyclins, resulting in similar dNTP depletion and antiviral effects. Parathion 222-226 interferon gamma Homo sapiens 44-71 29716923-8 2018 The IFNgamma+ signature was induced 2-fold (P = 0.003) by durvalumab after 8 weeks of therapy in patients with NSCLC, and baseline signature was associated with TMB but not survival in TCGA data.Conclusions: The IFNgamma+ mRNA signature may assist in identifying patients with improved outcomes with durvalumab, independent of PD-L1 assessed by IHC. 1,2,4,5-tetramethoxybenzene 161-164 interferon gamma Homo sapiens 4-12 29957387-0 2018 Decitabine induces regulatory T cells, inhibits the production of IFN-gamma and IL-17 and exerts preventive and therapeutic efficacy in rodent experimental autoimmune neuritis. Decitabine 0-10 interferon gamma Homo sapiens 66-75 30537798-6 2018 We also showed that IFN-gamma+IL17+ co-producing CD8+ T cells were reduced in patients under fingolimod therapy. Fingolimod Hydrochloride 93-103 interferon gamma Homo sapiens 20-29 30208836-5 2018 SO, ED, and GL stimulated production of pro-inflammatory IFN-gamma, IL-1beta, IL-2, IL-6, IL-8, TNF-alpha and anti-inflammatory IL-10. glycylleucine 12-14 interferon gamma Homo sapiens 57-66 30537802-7 2018 In CD4+ T cells treated with PMA+MLIF, the expression levels of IFN-gamma, TNF-alpha and IL-4 were strongly inhibited (p<0.001, p<0.001 and p<0.0094), compared to PMA treatment alone, for both, rhinitis and asthma. Tetradecanoylphorbol Acetate 29-32 interferon gamma Homo sapiens 64-73 30537802-7 2018 In CD4+ T cells treated with PMA+MLIF, the expression levels of IFN-gamma, TNF-alpha and IL-4 were strongly inhibited (p<0.001, p<0.001 and p<0.0094), compared to PMA treatment alone, for both, rhinitis and asthma. Tetradecanoylphorbol Acetate 172-175 interferon gamma Homo sapiens 64-73 30122920-0 2018 Synthesis of a hemin-containing copolymer as a novel immunostimulator that induces IFN-gamma production. copolymer 32-41 interferon gamma Homo sapiens 83-92 30122920-6 2018 The NIPAM-hemin copolymer induced the production of interferon (IFN)-gamma and interleukin (IL)-6 from peripheral blood mononuclear cells, although hemin and the NIPAM monomer individually did not induce the production of any cytokines. nipam-hemin copolymer 4-25 interferon gamma Homo sapiens 52-74 30122920-6 2018 The NIPAM-hemin copolymer induced the production of interferon (IFN)-gamma and interleukin (IL)-6 from peripheral blood mononuclear cells, although hemin and the NIPAM monomer individually did not induce the production of any cytokines. N-isopropylacrylamide 4-9 interferon gamma Homo sapiens 52-74 30122920-7 2018 The production of IFN-gamma induced by NIPAM-hemin was independent of toll-like receptor 9 and the NLRP3 inflammasome pathway. nipam-hemin 39-50 interferon gamma Homo sapiens 18-27 30122920-8 2018 Conclusion: Given that NIPAM-hemin induced IL-6 and IFN-gamma production in immune cells without any cytotoxic effects, NIPAM-hemin has potential therapeutic applications as a Th1-type adjuvant. nipam-hemin 23-34 interferon gamma Homo sapiens 52-61 30122920-8 2018 Conclusion: Given that NIPAM-hemin induced IL-6 and IFN-gamma production in immune cells without any cytotoxic effects, NIPAM-hemin has potential therapeutic applications as a Th1-type adjuvant. nipam-hemin 120-131 interferon gamma Homo sapiens 52-61 29512851-11 2018 Furthermore, the frequency of TIGIT+CD4+ T cells was significantly increased in patients with PV after 2 months of treatment with acitretin, with associated significant changes in IFN-gamma, IL-10and IL-17A plasma levels. Acitretin 130-139 interferon gamma Homo sapiens 180-189 28669666-5 2018 RESULTS: Resistant dextrin caused a significant decrease in levels of cortisol, KYN, KYN/TRP ratio, IFNgamma, IL12, IFNgamma/IL10 ratio, LPS, and a significant increase in the monocyte, GHQ, DASS, CD8, IL10, IL4 in the intervention group as compared with baseline. Dextrins 19-26 interferon gamma Homo sapiens 100-108 28669666-5 2018 RESULTS: Resistant dextrin caused a significant decrease in levels of cortisol, KYN, KYN/TRP ratio, IFNgamma, IL12, IFNgamma/IL10 ratio, LPS, and a significant increase in the monocyte, GHQ, DASS, CD8, IL10, IL4 in the intervention group as compared with baseline. Dextrins 19-26 interferon gamma Homo sapiens 116-124 29763582-10 2018 AU AqH induced expression of CD40 and CD80 on DC, which resulted in increased T cell proliferation and the production of GM-CSF, IFNgamma and TNFalpha. au aqh 0-6 interferon gamma Homo sapiens 129-137 29803914-8 2018 When combined, TLR3 + 8 and TLR4 + 8 synergistically optimized nicDC maturation and IFN-gamma secretion from nicotine-exposed NK (nicNK) during co-cultures. Nicotine 109-117 interferon gamma Homo sapiens 84-93 29803914-10 2018 However, the effector cells from TLR4 + 8 followed by TLR3 + 8 treated nicDC-nicNK-T co-cultures produced significantly more IFN-gamma when compared with aluminum salt treated co-culture. nicdc-nicnk-t 71-84 interferon gamma Homo sapiens 125-134 29402723-0 2018 Reduction of respiratory infections in asthma patients supplemented with vitamin D is related to increased serum IL-10 and IFNgamma levels and cathelicidin expression. Vitamin D 73-82 interferon gamma Homo sapiens 123-131 29402723-8 2018 RESULTS: Serum levels of IL-10 and IFNgamma increased significantly in the group of patients with vitamin D supplementation, while IL-5, IL-9, and IL-13 decreased significantly. Vitamin D 98-107 interferon gamma Homo sapiens 35-43 29532501-3 2018 Recently, we found that exposures to TBT caused increased secretion of two important proinflammatory cytokines, tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma). tributyltin 37-40 interferon gamma Homo sapiens 155-182 29926339-8 2018 Patients with history of frequent vaso-occlusive crisis and those with vascular complications had higher percentage of CD4+CD28null T lymphocytes and IFN-gamma while levels were significantly lower among hydroxyurea-treated patients. Hydroxyurea 204-215 interferon gamma Homo sapiens 150-159 29926339-9 2018 CD4+CD28null T lymphocytes were positively correlated to transfusional iron input while these cells and IFN-gamma were negatively correlated to cardiac T2* and duration of hydroxyurea therapy. Hydroxyurea 172-183 interferon gamma Homo sapiens 104-113 29532501-5 2018 The current study examined the mechanism of TBT-induced elevations of TNFalpha and IFNgamma secretion and found that the p38 mitogen-activated protein kinase pathway was essential to the ability of TBT to stimulate secretion. tributyltin 44-47 interferon gamma Homo sapiens 83-91 29532501-5 2018 The current study examined the mechanism of TBT-induced elevations of TNFalpha and IFNgamma secretion and found that the p38 mitogen-activated protein kinase pathway was essential to the ability of TBT to stimulate secretion. tributyltin 198-201 interferon gamma Homo sapiens 83-91 29532501-8 2018 The p38 mitogen-activated protein kinase pathway is also necessary for the TBT-induced increases in both TNFalpha and IFNgamma synthesis. tributyltin 75-78 interferon gamma Homo sapiens 118-126 29532501-9 2018 The role of increased transcription of TNFalpha and IFNgamma mRNA in response to TBT exposures as a possible explanation for the increased synthesis of these cytokines was also examined. tributyltin 81-84 interferon gamma Homo sapiens 52-60 29953319-4 2018 We found that, in contrast to anti-CD52 antibodies (Campath-1H homolog) that elicited high level of multiple inflammatory cytokines from human blood cells in vitro, other IgG1 antibodies with CRS-inducing potential consistently induced release of a single tested cytokine, interferon (IFN)-gamma, with a smaller magnitude than Campath. 3-cresol 192-195 interferon gamma Homo sapiens 273-295 29733248-5 2018 Using both SP and KDEL signals promotes higher interferon (IFN)-gamma production and a faster antitumor response than using only the SP, resulting in better tumor growth restraint and higher survival, indicating that the KDEL addition to an ER-directed antigen helps by shortening the time to response. Protein Sorting Signals 11-13 interferon gamma Homo sapiens 47-69 29953319-6 2018 Importantly, the magnitude of the IFN-gamma response elicited by IgG1 antibodies with CRS-inducing potential was determined by donor FcgammaRIIIa-V158F polymorphism. 3-cresol 86-89 interferon gamma Homo sapiens 34-43 29704546-3 2018 Comparison of our data with results from previously reported microarray and ChIP-seq experiments enabled us to identify candidate genes, which expression status reflects exposure of lung cancer cells to TCDD, and to predict processes, pathways (e.g. ER stress, Wnt/beta-cat, IFNgamma, EGFR/Erbb1), putative TFs (e.g. STAT, AP1, E2F1, TCF4), which may be implicated in adaptive response of lung cells to TCDD-induced AhR activation. Polychlorinated Dibenzodioxins 203-207 interferon gamma Homo sapiens 275-283 29627199-6 2018 Significantly increased IL-4, IL-5, IL-6, IL-10, tumor necrosis factor-alpha and IFN-gamma/IL-4 were found in the RAU group. rau 114-117 interferon gamma Homo sapiens 81-90 30008894-16 2018 In cellular immunoassays the average number of IFN-gamma associated spots was 143.3+-32.13 SFC/1x105 in the vaccine group, which was significantly enhanced compared with the PBS group (8+-5.29 SFC/1x105; P<0.01) and the AD-NC group (28+-5.13 SFC/1x105; P<0.01). Lead 174-177 interferon gamma Homo sapiens 47-56 29704546-3 2018 Comparison of our data with results from previously reported microarray and ChIP-seq experiments enabled us to identify candidate genes, which expression status reflects exposure of lung cancer cells to TCDD, and to predict processes, pathways (e.g. ER stress, Wnt/beta-cat, IFNgamma, EGFR/Erbb1), putative TFs (e.g. STAT, AP1, E2F1, TCF4), which may be implicated in adaptive response of lung cells to TCDD-induced AhR activation. Polychlorinated Dibenzodioxins 403-407 interferon gamma Homo sapiens 275-283 29760146-8 2018 Furthermore, CAS did not negatively affect the growth or metabolic activity of macrophages; rather, it sensitized those immune cells to produce interferon gamma and interleukin 6, which, in turn, might have aided in the phagocytosis of cryptococcal cells. cas 13-16 interferon gamma Homo sapiens 144-178 30111422-10 2018 The relative expression level of IFN-gamma in bone marrow mononuclear cells of the ITP patients in newly diagnosed group was higher than that in the control group and the complete remission group(P<0.001). Inosine Triphosphate 83-86 interferon gamma Homo sapiens 33-42 30051674-2 2018 Results: IFN-gamma was found to be higher inthe GCF of the CP group before NSPT in relation to the HP group (p<0.05), and it had significant higher levels afterseven days of NSPT (p<0.05). Hematoporphyrins 99-101 interferon gamma Homo sapiens 9-18 29920284-7 2018 Lovastatin given before M1 polarization downregulated M1 marker genes but enhanced the M1 phenotype in macrophages pre-polarized with LPS and IFNgamma. Lovastatin 0-10 interferon gamma Homo sapiens 142-150 30054566-6 2018 IL-1beta and IFN- gamma significantly increased IL-6 production in HNECs derived from CRS patients and controls, however, a dose-dependent effect was observed in CRS-derived HNECs only. 3-cresol 86-89 interferon gamma Homo sapiens 13-23 30054566-6 2018 IL-1beta and IFN- gamma significantly increased IL-6 production in HNECs derived from CRS patients and controls, however, a dose-dependent effect was observed in CRS-derived HNECs only. 3-cresol 162-165 interferon gamma Homo sapiens 13-23 29891601-1 2018 Evidence is provided that solithromycin is a bactericidal against not only fast-growing chlamydial organisms but also those slowed by gamma interferon (IFN-gamma) in vitro At sublethal concentrations, Sol impedes homotypic fusion of Chlamydia-containing vacuoles and reduces secretion of the type III secretion (T3S) effector IncA. solithromycin 26-39 interferon gamma Homo sapiens 134-161