PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
30783101-0	2019	Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.	Cholesterol	40-51	oxysterol binding protein like 1A	Homo sapiens	26-30
34864207-4	2022	The long isoform of ORP1 (ORP1 L), which also targets ER-late endosome (LE)/Lys MCS, has the capacity to mediate cholesterol transport either from ER to LE or in the opposite direction.	Cholesterol	113-124	oxysterol binding protein like 1A	Homo sapiens	20-24
34864207-6	2022	ORP2, the closest relative of ORP1, is mainly cytosolic, but also targets PI(4,5)P2-rich endosomal compartments.	pi(4,5)p2	74-83	oxysterol binding protein like 1A	Homo sapiens	30-34
32023146-0	2020	Oxysterol binding protein-related protein 1 (ORP1) variants have opposing cholesterol transport activities from the endolysosomes.	Cholesterol	74-85	oxysterol binding protein like 1A	Homo sapiens	0-43
32023146-0	2020	Oxysterol binding protein-related protein 1 (ORP1) variants have opposing cholesterol transport activities from the endolysosomes.	Cholesterol	74-85	oxysterol binding protein like 1A	Homo sapiens	45-49
32023146-4	2020	ORP1-null cells accumulated cholesterol in LEL and had reduced plasma membrane (PM) cholesterol.	Cholesterol	28-39	oxysterol binding protein like 1A	Homo sapiens	0-4
32023146-4	2020	ORP1-null cells accumulated cholesterol in LEL and had reduced plasma membrane (PM) cholesterol.	Cholesterol	84-95	oxysterol binding protein like 1A	Homo sapiens	0-4
32023146-6	2020	Expression of ORP2, another truncated variant, also restored PM cholesterol in ORP1-null cells.	Cholesterol	64-75	oxysterol binding protein like 1A	Homo sapiens	79-83
32023146-8	2020	As a consequence of reduced delivery of cholesterol to the PM in ORP1-null cells, cholesterol was diverted to the ER resulting in normalization of de novo cholesterol synthesis.	Cholesterol	40-51	oxysterol binding protein like 1A	Homo sapiens	65-69
32023146-8	2020	As a consequence of reduced delivery of cholesterol to the PM in ORP1-null cells, cholesterol was diverted to the ER resulting in normalization of de novo cholesterol synthesis.	Cholesterol	82-93	oxysterol binding protein like 1A	Homo sapiens	65-69
32023146-8	2020	As a consequence of reduced delivery of cholesterol to the PM in ORP1-null cells, cholesterol was diverted to the ER resulting in normalization of de novo cholesterol synthesis.	Cholesterol	82-93	oxysterol binding protein like 1A	Homo sapiens	65-69
32023146-9	2020	The deficiency in PM cholesterol also reduced ABCA1-dependent cholesterol efflux and LDL receptor activity in ORP1-null cells.	Cholesterol	21-32	oxysterol binding protein like 1A	Homo sapiens	110-114
30783101-0	2019	Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.	pi(4,5)p2	65-74	oxysterol binding protein like 1A	Homo sapiens	26-30
30783101-0	2019	Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.	phosphoinositide-3,4-bisphosphate	75-84	oxysterol binding protein like 1A	Homo sapiens	26-30
30783101-2	2019	Here, we show in vitro that ORP1 is a PI(4,5)P2- or PI(3,4)P2-dependent cholesterol transporter, but cannot transport any PIPs.	(4,5)p2	40-47	oxysterol binding protein like 1A	Homo sapiens	28-32
30783101-2	2019	Here, we show in vitro that ORP1 is a PI(4,5)P2- or PI(3,4)P2-dependent cholesterol transporter, but cannot transport any PIPs.	(3,4)p2	54-61	oxysterol binding protein like 1A	Homo sapiens	28-32
30783101-2	2019	Here, we show in vitro that ORP1 is a PI(4,5)P2- or PI(3,4)P2-dependent cholesterol transporter, but cannot transport any PIPs.	Phosphatidylinositol Phosphates	122-126	oxysterol binding protein like 1A	Homo sapiens	28-32
30783101-4	2019	Structures of the lipid-binding domain of ORP1 (ORP1-ORD) in complex with cholesterol or PI(4,5)P2 display open conformations essential for ORP function.	Cholesterol	74-85	oxysterol binding protein like 1A	Homo sapiens	42-46
30783101-4	2019	Structures of the lipid-binding domain of ORP1 (ORP1-ORD) in complex with cholesterol or PI(4,5)P2 display open conformations essential for ORP function.	Cholesterol	74-85	oxysterol binding protein like 1A	Homo sapiens	48-56
30783101-4	2019	Structures of the lipid-binding domain of ORP1 (ORP1-ORD) in complex with cholesterol or PI(4,5)P2 display open conformations essential for ORP function.	pi(4,5)p2	89-98	oxysterol binding protein like 1A	Homo sapiens	42-46
30783101-4	2019	Structures of the lipid-binding domain of ORP1 (ORP1-ORD) in complex with cholesterol or PI(4,5)P2 display open conformations essential for ORP function.	pi(4,5)p2	89-98	oxysterol binding protein like 1A	Homo sapiens	48-56
30783101-5	2019	PI(4,5)P2/PI(3,4)P2 can facilitate ORP1-mediated cholesterol transport by promoting membrane targeting and cholesterol extraction.	(4,5)p2	2-9	oxysterol binding protein like 1A	Homo sapiens	35-39
30783101-5	2019	PI(4,5)P2/PI(3,4)P2 can facilitate ORP1-mediated cholesterol transport by promoting membrane targeting and cholesterol extraction.	phosphoinositide-3,4-bisphosphate	10-19	oxysterol binding protein like 1A	Homo sapiens	35-39
30783101-5	2019	PI(4,5)P2/PI(3,4)P2 can facilitate ORP1-mediated cholesterol transport by promoting membrane targeting and cholesterol extraction.	Cholesterol	49-60	oxysterol binding protein like 1A	Homo sapiens	35-39
30783101-5	2019	PI(4,5)P2/PI(3,4)P2 can facilitate ORP1-mediated cholesterol transport by promoting membrane targeting and cholesterol extraction.	Cholesterol	107-118	oxysterol binding protein like 1A	Homo sapiens	35-39
30721249-2	2019	ORP1 transports cholesterol at the interface between the late endosomes/lysosomes (LELs) and the endoplasmic reticulum (ER).	Cholesterol	16-27	oxysterol binding protein like 1A	Homo sapiens	0-4
30721249-4	2019	Here, we determined the crystal structure of human ORP1 ANK domain in complex with the GTP-bound form of Rab7.	Guanosine Triphosphate	87-90	oxysterol binding protein like 1A	Homo sapiens	51-55
27105157-0	2016	A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity.	Cholesterol	68-79	oxysterol binding protein like 1A	Homo sapiens	30-37
31787639-4	2019	We created membrane-targeted versions of glutathione and hydrogen peroxide sensors by attaching palmitoylation signals to existing sensors (Grx1-roGFP2 and roGFP2-Orp1, respectively), and demonstrated the nonuniform distribution of these oxidative elements within cytosol.	Glutathione	41-52	oxysterol binding protein like 1A	Homo sapiens	163-167
31787639-4	2019	We created membrane-targeted versions of glutathione and hydrogen peroxide sensors by attaching palmitoylation signals to existing sensors (Grx1-roGFP2 and roGFP2-Orp1, respectively), and demonstrated the nonuniform distribution of these oxidative elements within cytosol.	Hydrogen Peroxide	57-74	oxysterol binding protein like 1A	Homo sapiens	163-167
27345457-3	2017	Oxysterol-binding protein-related protein 1 long (ORP1L) is a mammalian lipid-binding protein that plays a dual role in cholesterol-dependent endocytic trafficking as well as interactions between endosomes and the endoplasmic reticulum (ER).	Cholesterol	120-131	oxysterol binding protein like 1A	Homo sapiens	0-43
27105157-0	2016	A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity.	Cholesterol	100-111	oxysterol binding protein like 1A	Homo sapiens	30-37
27105157-8	2016	Our observations provide evidence that a familial loss-of-function mutation in OSBPL1A affects the first step of the reverse cholesterol transport process and associates with a low HDL-C phenotype.	Cholesterol	125-136	oxysterol binding protein like 1A	Homo sapiens	79-86
15617515-0	2005	Identification and assessment of the role of a nominal phospholipid binding region of ORP1S (oxysterol-binding-protein-related protein 1 short) in the regulation of vesicular transport.	Phospholipids	55-67	oxysterol binding protein like 1A	Homo sapiens	93-136
23115269-4	2013	Incubation of bicarbonate treated sperm with oxysterol-binding proteins (ORP-1 or ORP-2) caused a reduction of >70% of the formed oxysterols in the sperm pellet but no free sterol depletion.	Bicarbonates	14-25	oxysterol binding protein like 1A	Homo sapiens	73-78
23115269-4	2013	Incubation of bicarbonate treated sperm with oxysterol-binding proteins (ORP-1 or ORP-2) caused a reduction of >70% of the formed oxysterols in the sperm pellet but no free sterol depletion.	Oxysterols	133-143	oxysterol binding protein like 1A	Homo sapiens	73-78
23115269-4	2013	Incubation of bicarbonate treated sperm with oxysterol-binding proteins (ORP-1 or ORP-2) caused a reduction of >70% of the formed oxysterols in the sperm pellet but no free sterol depletion.	Sterols	48-54	oxysterol binding protein like 1A	Homo sapiens	73-78
17428193-3	2007	ORP1 and ORP2 [a short ORP consisting of an ORD (OSBP-related ligand-binding domain) only] were in vitro shown to bind 25OH.	25oh	119-123	oxysterol binding protein like 1A	Homo sapiens	0-4
17428193-11	2007	The present study identifies ORP1 and ORP2 as OSBPs and suggests that most of the mammalian ORPs are able to bind sterols.	osbps	46-51	oxysterol binding protein like 1A	Homo sapiens	29-33
17428193-11	2007	The present study identifies ORP1 and ORP2 as OSBPs and suggests that most of the mammalian ORPs are able to bind sterols.	Sterols	114-121	oxysterol binding protein like 1A	Homo sapiens	29-33
10588946-10	1999	This indicates that ORP-1 may play an important role in maintaining the sterol balance in cells of the central nervous system.	Sterols	72-78	oxysterol binding protein like 1A	Homo sapiens	20-25