PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23110364-6	2012	Cyclic AMP acting via PKA thus has a broad impact on protein expression in mammalian cells, including in the regulation of Gsr and oxidative stress.	Cyclic AMP	0-10	gutter shaped root	Mus musculus	123-126
23623936-1	2013	Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, a major cellular antioxidant.	Glutathione Disulfide	55-76	gutter shaped root	Mus musculus	23-26
23623936-1	2013	Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, a major cellular antioxidant.	Glutathione	55-66	gutter shaped root	Mus musculus	23-26
23623936-10	2013	In response to thioglycollate stimulation, Gsr-deficient mice mobilized far fewer phagocytes, including neutrophils, macrophages, and eosinophils, into their peritoneal cavities than did wild-type mice.	Thioglycolates	15-29	gutter shaped root	Mus musculus	43-46
22279102-1	2012	Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, which plays an important role in the bactericidal function of phagocytes.	Glutathione Disulfide	55-76	gutter shaped root	Mus musculus	23-26
22279102-1	2012	Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, which plays an important role in the bactericidal function of phagocytes.	Glutathione	55-66	gutter shaped root	Mus musculus	23-26
22279102-6	2012	Although Gsr catalyzes the regeneration of glutathione, a major cellular antioxidant, Gsr-deficient neutrophils paradoxically produced far less reactive oxygen species upon activation both ex vivo and in vivo.	Glutathione	43-54	gutter shaped root	Mus musculus	86-89
22279102-6	2012	Although Gsr catalyzes the regeneration of glutathione, a major cellular antioxidant, Gsr-deficient neutrophils paradoxically produced far less reactive oxygen species upon activation both ex vivo and in vivo.	Reactive Oxygen Species	144-167	gutter shaped root	Mus musculus	86-89
22279102-6	2012	Although Gsr catalyzes the regeneration of glutathione, a major cellular antioxidant, Gsr-deficient neutrophils paradoxically produced far less reactive oxygen species upon activation both ex vivo and in vivo.	Glutathione	43-54	gutter shaped root	Mus musculus	9-12
7910817-3	1994	Further, using spectrophotometric techniques, the activities of several glutathione (GSH)-related enzymes; glutathione S-transferase (GST), glutathione peroxidase (GSH-PX), glutathione reductase (GSR), gamma-glutamylcysteine synthetase (GCS) and gamma-glutamyl transpeptidase (GGT) were also measured.	Glutathione	72-83	gutter shaped root	Mus musculus	196-199
22279102-9	2012	Biochemical analysis revealed that the hexose monophosphate shunt was compromised in Gsr-deficient neutrophils.	hexose monophosphate	39-59	gutter shaped root	Mus musculus	85-88
20404047-6	2010	Phenytoin also exerted an effect on neuroprotection-related genes, namely the survival-promoting and antioxidant genes v-akt murine thymoma viral oncogene homolog 1 (Akt1), FK506 binding protein 12-rapamycin associated protein 1 (Frap1), glutathione reductase (Gsr) and glutamate cysteine ligase catalytic subunit (Gclc).	Phenytoin	0-9	gutter shaped root	Mus musculus	261-264
34262291-1	2021	Introduction: Glutathione reductase (GSR) provides reduced glutathione (GSH) to maintain redox homeostasis.	Glutathione	59-70	gutter shaped root	Mus musculus	37-40
34469757-7	2022	Dau could up-regulate the expression of glutathione peroxidase 4 (GPX4) in intracerebral hemorrhage(ICH) model, normal cells and GPX4 knockdown cells in vitro, and simultaneously up-regulate the expression of GSR in ICH mice.	3-Deazauridine	0-3	gutter shaped root	Mus musculus	209-212
34469757-9	2022	It was tesified that Dauricine(Dau) could inhibit ferroptosis of nerve cells and alleviate brain injury after intracerebral hemorrhage by upregulating glutathione peroxidase 4 (GPX4) and glutathione reductase (GSR) co-expression.	dauricine	21-30	gutter shaped root	Mus musculus	210-213
34469757-9	2022	It was tesified that Dauricine(Dau) could inhibit ferroptosis of nerve cells and alleviate brain injury after intracerebral hemorrhage by upregulating glutathione peroxidase 4 (GPX4) and glutathione reductase (GSR) co-expression.	3-Deazauridine	31-34	gutter shaped root	Mus musculus	210-213
34722338-6	2021	While heme oxygenase 1 (HO-1) transcription is independent of the genetic background, the transcription of glutathione reductase (Gsr) and of cysteine/glutamate exchange transporter (Slc7a11), involved in glutathione accumulation, was differentially regulated in BMdMs from both mouse strains.	Glutathione	205-216	gutter shaped root	Mus musculus	130-133
34262291-1	2021	Introduction: Glutathione reductase (GSR) provides reduced glutathione (GSH) to maintain redox homeostasis.	Glutathione	72-75	gutter shaped root	Mus musculus	37-40
34262291-15	2021	The STAT3 inhibitor 6-nitrobenzo(b)thiophene 1,1-dioxide (Stattic) also inhibited the enzymatic activity of GSR and induced the death of cervical cancer cells.	6-nitrobenzo(b)thiophene 1,1-dioxide	20-56	gutter shaped root	Mus musculus	108-111
34262291-15	2021	The STAT3 inhibitor 6-nitrobenzo(b)thiophene 1,1-dioxide (Stattic) also inhibited the enzymatic activity of GSR and induced the death of cervical cancer cells.	stattic	58-65	gutter shaped root	Mus musculus	108-111
34262291-17	2021	Mechanistically, tumor cell death induced by Stattic-mediated GSR inhibition was ROS-dependent, since the ROS scavengers GSH and N-acetyl cysteine (NAC) reversed the effect of Stattic.	Reactive Oxygen Species	81-84	gutter shaped root	Mus musculus	62-65
34262291-17	2021	Mechanistically, tumor cell death induced by Stattic-mediated GSR inhibition was ROS-dependent, since the ROS scavengers GSH and N-acetyl cysteine (NAC) reversed the effect of Stattic.	Reactive Oxygen Species	106-109	gutter shaped root	Mus musculus	62-65
34262291-17	2021	Mechanistically, tumor cell death induced by Stattic-mediated GSR inhibition was ROS-dependent, since the ROS scavengers GSH and N-acetyl cysteine (NAC) reversed the effect of Stattic.	Glutathione	121-124	gutter shaped root	Mus musculus	62-65
34262291-17	2021	Mechanistically, tumor cell death induced by Stattic-mediated GSR inhibition was ROS-dependent, since the ROS scavengers GSH and N-acetyl cysteine (NAC) reversed the effect of Stattic.	Acetylcysteine	129-146	gutter shaped root	Mus musculus	62-65
34262291-17	2021	Mechanistically, tumor cell death induced by Stattic-mediated GSR inhibition was ROS-dependent, since the ROS scavengers GSH and N-acetyl cysteine (NAC) reversed the effect of Stattic.	Acetylcysteine	148-151	gutter shaped root	Mus musculus	62-65
34262291-19	2021	Conclusion: Stattic inhibits the enzymatic activity of GSR and induces STAT3-independent but ROS-dependent death of cervical cancer cells, suggesting its potential application as a therapeutic agent for human cervical cancers.	stattic	12-19	gutter shaped root	Mus musculus	55-58
34262291-19	2021	Conclusion: Stattic inhibits the enzymatic activity of GSR and induces STAT3-independent but ROS-dependent death of cervical cancer cells, suggesting its potential application as a therapeutic agent for human cervical cancers.	Reactive Oxygen Species	93-96	gutter shaped root	Mus musculus	55-58
33673577-2	2021	In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains hepatic levels of reduced glutathione (GSH).	Methionine	91-101	gutter shaped root	Mus musculus	62-65
33673577-2	2021	In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains hepatic levels of reduced glutathione (GSH).	Methionine	91-101	gutter shaped root	Mus musculus	73-76
33673577-2	2021	In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains hepatic levels of reduced glutathione (GSH).	Glutathione	148-159	gutter shaped root	Mus musculus	62-65
33673577-2	2021	In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains hepatic levels of reduced glutathione (GSH).	Glutathione	161-164	gutter shaped root	Mus musculus	62-65
33673577-11	2021	Curiously, however, despite depleting GSH, ascorbate treatment diminished basal DNA damage and oxidative stress markers in TrxR1/Gsr-null livers.	Ascorbic Acid	43-52	gutter shaped root	Mus musculus	129-132
32178678-13	2020	Myrin -p Forte increased (p < 0.001) lipid peroxidation and H2O2 while decreased (p < 0.001) the activity level of CAT, SOD, POD, GPx, GST, GSR, gamma-GT and GSH.	Myrin P	0-8	gutter shaped root	Mus musculus	140-143
32651830-4	2020	Enhanced relative expression of the GCLM gene was found in all studied drug-resistant strains; the expression of the GSR and GPX1 genes was increased only in cells of the cyclophosphamide-resistant strain.	Cyclophosphamide	171-187	gutter shaped root	Mus musculus	117-120
31059718-9	2019	Strain-dependent differences of the anxiety in mice are probably related to the anxiolytic effects of methylglyoxal, a substrate for Glo1 and Gsr.	Pyruvaldehyde	102-115	gutter shaped root	Mus musculus	142-145
31501257-1	2019	Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, which plays an important role in redox regulation.	Glutathione Disulfide	55-76	gutter shaped root	Mus musculus	23-26
31501257-1	2019	Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, which plays an important role in redox regulation.	Glutathione	55-66	gutter shaped root	Mus musculus	23-26
28658624-2	2017	NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant systems and deoxyribonucleotide synthesis.	NADP	0-5	gutter shaped root	Mus musculus	148-151
31262352-4	2019	Since glutathione is a central component of a complex system involved in preserving cellular redox status, we aimed to study whether the expression of the glutathione reductase (Gsr) gene, which encodes an essential enzyme for cellular redox homeostasis, is modulated by the transcription factors critical for self-renewal and pluripotency of ESCs.	Glutathione	6-17	gutter shaped root	Mus musculus	178-181
29732722-10	2018	Eight more candidate genes (Abcc3, Gsr, Gclc, Mthfd1, Gart, Bche, Slc25a32, and Slc44a2) were identified by examining the DEGs of those genes involved in the extended folate metabolic pathway between FA-responsive and FA-resistant mutants.	Folic Acid	167-173	gutter shaped root	Mus musculus	35-38
29567975-2	2018	In the mitochondria, IDH2 also plays a key role in protecting mitochondrial components from oxidative stress by supplying NADPH to both glutathione reductase (GSR) and thioredoxin reductase 2 (TXNRD2).	NADP	122-127	gutter shaped root	Mus musculus	159-162
31097586-4	2019	All genotypes, including TrxR1/Gsr-null, were susceptible to N-diethylnitrosamine (DEN)-induced liver cancer, indicating that loss of these antioxidant systems did not prevent cancer cell survival.	Diethylnitrosamine	61-81	gutter shaped root	Mus musculus	31-34
28658624-2	2017	NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant systems and deoxyribonucleotide synthesis.	Disulfides	50-59	gutter shaped root	Mus musculus	148-151
28658624-2	2017	NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant systems and deoxyribonucleotide synthesis.	Glutathione Disulfide	64-85	gutter shaped root	Mus musculus	148-151
28658624-3	2017	Mouse livers lacking both TrxR1 and Gsr sustain these essential activities using an NADPH-independent methionine-consuming pathway; however, it remains unclear how this reducing power is distributed.	NADP	84-89	gutter shaped root	Mus musculus	36-39
28658624-3	2017	Mouse livers lacking both TrxR1 and Gsr sustain these essential activities using an NADPH-independent methionine-consuming pathway; however, it remains unclear how this reducing power is distributed.	Methionine	102-112	gutter shaped root	Mus musculus	36-39
28512249-5	2017	We also observed p62-dependent changes in Gcl, Gsr, Nqo1, and Srxn1, which were decreased by p62 attenuation and implicated in GSH production and utilization.	Glutathione	127-130	gutter shaped root	Mus musculus	47-50
28081255-4	2017	NM administration had the following DNA methylation effects: AuNP 60 nm induced CpG hypermethylation in Atm, Cdk and Gsr genes and hypomethylation in Gpx; Gsr and Trp53 showed changes in methylation between low- and high-dose AuNP, 60 and 250 nm respectively, and AuNP had size effects on methylation for Trp53.	aunp	61-65	gutter shaped root	Mus musculus	117-120
27048381-11	2016	Further, the transcript levels of Gclc, Gsr and Gstmicro and protein levels of NQO1, catalase, GPX1 were profoundly downregulated along with GSH depletion and increased oxidative stress in Nrf2(-/-) mice when compared to its WT counterparts after HIES.	Glutathione	141-144	gutter shaped root	Mus musculus	40-43