PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 27048381-11 2016 Further, the transcript levels of Gclc, Gsr and Gstmicro and protein levels of NQO1, catalase, GPX1 were profoundly downregulated along with GSH depletion and increased oxidative stress in Nrf2(-/-) mice when compared to its WT counterparts after HIES. Glutathione 141-144 gutter shaped root Mus musculus 40-43 28081255-4 2017 NM administration had the following DNA methylation effects: AuNP 60 nm induced CpG hypermethylation in Atm, Cdk and Gsr genes and hypomethylation in Gpx; Gsr and Trp53 showed changes in methylation between low- and high-dose AuNP, 60 and 250 nm respectively, and AuNP had size effects on methylation for Trp53. aunp 61-65 gutter shaped root Mus musculus 117-120 20404047-6 2010 Phenytoin also exerted an effect on neuroprotection-related genes, namely the survival-promoting and antioxidant genes v-akt murine thymoma viral oncogene homolog 1 (Akt1), FK506 binding protein 12-rapamycin associated protein 1 (Frap1), glutathione reductase (Gsr) and glutamate cysteine ligase catalytic subunit (Gclc). Phenytoin 0-9 gutter shaped root Mus musculus 261-264 23110364-6 2012 Cyclic AMP acting via PKA thus has a broad impact on protein expression in mammalian cells, including in the regulation of Gsr and oxidative stress. Cyclic AMP 0-10 gutter shaped root Mus musculus 123-126 22279102-1 2012 Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, which plays an important role in the bactericidal function of phagocytes. Glutathione Disulfide 55-76 gutter shaped root Mus musculus 23-26 22279102-1 2012 Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, which plays an important role in the bactericidal function of phagocytes. Glutathione 55-66 gutter shaped root Mus musculus 23-26 22279102-6 2012 Although Gsr catalyzes the regeneration of glutathione, a major cellular antioxidant, Gsr-deficient neutrophils paradoxically produced far less reactive oxygen species upon activation both ex vivo and in vivo. Glutathione 43-54 gutter shaped root Mus musculus 9-12 22279102-6 2012 Although Gsr catalyzes the regeneration of glutathione, a major cellular antioxidant, Gsr-deficient neutrophils paradoxically produced far less reactive oxygen species upon activation both ex vivo and in vivo. Glutathione 43-54 gutter shaped root Mus musculus 86-89 22279102-6 2012 Although Gsr catalyzes the regeneration of glutathione, a major cellular antioxidant, Gsr-deficient neutrophils paradoxically produced far less reactive oxygen species upon activation both ex vivo and in vivo. Reactive Oxygen Species 144-167 gutter shaped root Mus musculus 86-89 22279102-9 2012 Biochemical analysis revealed that the hexose monophosphate shunt was compromised in Gsr-deficient neutrophils. hexose monophosphate 39-59 gutter shaped root Mus musculus 85-88 23623936-1 2013 Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, a major cellular antioxidant. Glutathione Disulfide 55-76 gutter shaped root Mus musculus 23-26 23623936-1 2013 Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, a major cellular antioxidant. Glutathione 55-66 gutter shaped root Mus musculus 23-26 23623936-10 2013 In response to thioglycollate stimulation, Gsr-deficient mice mobilized far fewer phagocytes, including neutrophils, macrophages, and eosinophils, into their peritoneal cavities than did wild-type mice. Thioglycolates 15-29 gutter shaped root Mus musculus 43-46 34469757-7 2022 Dau could up-regulate the expression of glutathione peroxidase 4 (GPX4) in intracerebral hemorrhage(ICH) model, normal cells and GPX4 knockdown cells in vitro, and simultaneously up-regulate the expression of GSR in ICH mice. 3-Deazauridine 0-3 gutter shaped root Mus musculus 209-212 7910817-3 1994 Further, using spectrophotometric techniques, the activities of several glutathione (GSH)-related enzymes; glutathione S-transferase (GST), glutathione peroxidase (GSH-PX), glutathione reductase (GSR), gamma-glutamylcysteine synthetase (GCS) and gamma-glutamyl transpeptidase (GGT) were also measured. Glutathione 72-83 gutter shaped root Mus musculus 196-199 34469757-9 2022 It was tesified that Dauricine(Dau) could inhibit ferroptosis of nerve cells and alleviate brain injury after intracerebral hemorrhage by upregulating glutathione peroxidase 4 (GPX4) and glutathione reductase (GSR) co-expression. dauricine 21-30 gutter shaped root Mus musculus 210-213 34469757-9 2022 It was tesified that Dauricine(Dau) could inhibit ferroptosis of nerve cells and alleviate brain injury after intracerebral hemorrhage by upregulating glutathione peroxidase 4 (GPX4) and glutathione reductase (GSR) co-expression. 3-Deazauridine 31-34 gutter shaped root Mus musculus 210-213 33673577-2 2021 In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains hepatic levels of reduced glutathione (GSH). Methionine 91-101 gutter shaped root Mus musculus 62-65 34722338-6 2021 While heme oxygenase 1 (HO-1) transcription is independent of the genetic background, the transcription of glutathione reductase (Gsr) and of cysteine/glutamate exchange transporter (Slc7a11), involved in glutathione accumulation, was differentially regulated in BMdMs from both mouse strains. Glutathione 205-216 gutter shaped root Mus musculus 130-133 34262291-1 2021 Introduction: Glutathione reductase (GSR) provides reduced glutathione (GSH) to maintain redox homeostasis. Glutathione 59-70 gutter shaped root Mus musculus 37-40 34262291-1 2021 Introduction: Glutathione reductase (GSR) provides reduced glutathione (GSH) to maintain redox homeostasis. Glutathione 72-75 gutter shaped root Mus musculus 37-40 34262291-15 2021 The STAT3 inhibitor 6-nitrobenzo(b)thiophene 1,1-dioxide (Stattic) also inhibited the enzymatic activity of GSR and induced the death of cervical cancer cells. 6-nitrobenzo(b)thiophene 1,1-dioxide 20-56 gutter shaped root Mus musculus 108-111 34262291-15 2021 The STAT3 inhibitor 6-nitrobenzo(b)thiophene 1,1-dioxide (Stattic) also inhibited the enzymatic activity of GSR and induced the death of cervical cancer cells. stattic 58-65 gutter shaped root Mus musculus 108-111 34262291-17 2021 Mechanistically, tumor cell death induced by Stattic-mediated GSR inhibition was ROS-dependent, since the ROS scavengers GSH and N-acetyl cysteine (NAC) reversed the effect of Stattic. Reactive Oxygen Species 81-84 gutter shaped root Mus musculus 62-65 34262291-17 2021 Mechanistically, tumor cell death induced by Stattic-mediated GSR inhibition was ROS-dependent, since the ROS scavengers GSH and N-acetyl cysteine (NAC) reversed the effect of Stattic. Reactive Oxygen Species 106-109 gutter shaped root Mus musculus 62-65 34262291-17 2021 Mechanistically, tumor cell death induced by Stattic-mediated GSR inhibition was ROS-dependent, since the ROS scavengers GSH and N-acetyl cysteine (NAC) reversed the effect of Stattic. Glutathione 121-124 gutter shaped root Mus musculus 62-65 34262291-17 2021 Mechanistically, tumor cell death induced by Stattic-mediated GSR inhibition was ROS-dependent, since the ROS scavengers GSH and N-acetyl cysteine (NAC) reversed the effect of Stattic. Acetylcysteine 129-146 gutter shaped root Mus musculus 62-65 34262291-17 2021 Mechanistically, tumor cell death induced by Stattic-mediated GSR inhibition was ROS-dependent, since the ROS scavengers GSH and N-acetyl cysteine (NAC) reversed the effect of Stattic. Acetylcysteine 148-151 gutter shaped root Mus musculus 62-65 34262291-19 2021 Conclusion: Stattic inhibits the enzymatic activity of GSR and induces STAT3-independent but ROS-dependent death of cervical cancer cells, suggesting its potential application as a therapeutic agent for human cervical cancers. stattic 12-19 gutter shaped root Mus musculus 55-58 34262291-19 2021 Conclusion: Stattic inhibits the enzymatic activity of GSR and induces STAT3-independent but ROS-dependent death of cervical cancer cells, suggesting its potential application as a therapeutic agent for human cervical cancers. Reactive Oxygen Species 93-96 gutter shaped root Mus musculus 55-58 33673577-2 2021 In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains hepatic levels of reduced glutathione (GSH). Methionine 91-101 gutter shaped root Mus musculus 73-76 33673577-2 2021 In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains hepatic levels of reduced glutathione (GSH). Glutathione 148-159 gutter shaped root Mus musculus 62-65 33673577-2 2021 In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains hepatic levels of reduced glutathione (GSH). Glutathione 161-164 gutter shaped root Mus musculus 62-65 33673577-11 2021 Curiously, however, despite depleting GSH, ascorbate treatment diminished basal DNA damage and oxidative stress markers in TrxR1/Gsr-null livers. Ascorbic Acid 43-52 gutter shaped root Mus musculus 129-132 31501257-1 2019 Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, which plays an important role in redox regulation. Glutathione Disulfide 55-76 gutter shaped root Mus musculus 23-26 32178678-13 2020 Myrin -p Forte increased (p < 0.001) lipid peroxidation and H2O2 while decreased (p < 0.001) the activity level of CAT, SOD, POD, GPx, GST, GSR, gamma-GT and GSH. Myrin P 0-8 gutter shaped root Mus musculus 140-143 32651830-4 2020 Enhanced relative expression of the GCLM gene was found in all studied drug-resistant strains; the expression of the GSR and GPX1 genes was increased only in cells of the cyclophosphamide-resistant strain. Cyclophosphamide 171-187 gutter shaped root Mus musculus 117-120 31501257-1 2019 Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, which plays an important role in redox regulation. Glutathione 55-66 gutter shaped root Mus musculus 23-26 31059718-9 2019 Strain-dependent differences of the anxiety in mice are probably related to the anxiolytic effects of methylglyoxal, a substrate for Glo1 and Gsr. Pyruvaldehyde 102-115 gutter shaped root Mus musculus 142-145 31262352-4 2019 Since glutathione is a central component of a complex system involved in preserving cellular redox status, we aimed to study whether the expression of the glutathione reductase (Gsr) gene, which encodes an essential enzyme for cellular redox homeostasis, is modulated by the transcription factors critical for self-renewal and pluripotency of ESCs. Glutathione 6-17 gutter shaped root Mus musculus 178-181 31097586-4 2019 All genotypes, including TrxR1/Gsr-null, were susceptible to N-diethylnitrosamine (DEN)-induced liver cancer, indicating that loss of these antioxidant systems did not prevent cancer cell survival. Diethylnitrosamine 61-81 gutter shaped root Mus musculus 31-34 28658624-2 2017 NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant systems and deoxyribonucleotide synthesis. NADP 0-5 gutter shaped root Mus musculus 148-151 29732722-10 2018 Eight more candidate genes (Abcc3, Gsr, Gclc, Mthfd1, Gart, Bche, Slc25a32, and Slc44a2) were identified by examining the DEGs of those genes involved in the extended folate metabolic pathway between FA-responsive and FA-resistant mutants. Folic Acid 167-173 gutter shaped root Mus musculus 35-38 29567975-2 2018 In the mitochondria, IDH2 also plays a key role in protecting mitochondrial components from oxidative stress by supplying NADPH to both glutathione reductase (GSR) and thioredoxin reductase 2 (TXNRD2). NADP 122-127 gutter shaped root Mus musculus 159-162 28658624-2 2017 NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant systems and deoxyribonucleotide synthesis. Disulfides 50-59 gutter shaped root Mus musculus 148-151 28658624-2 2017 NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant systems and deoxyribonucleotide synthesis. Glutathione Disulfide 64-85 gutter shaped root Mus musculus 148-151 28658624-3 2017 Mouse livers lacking both TrxR1 and Gsr sustain these essential activities using an NADPH-independent methionine-consuming pathway; however, it remains unclear how this reducing power is distributed. NADP 84-89 gutter shaped root Mus musculus 36-39 28658624-3 2017 Mouse livers lacking both TrxR1 and Gsr sustain these essential activities using an NADPH-independent methionine-consuming pathway; however, it remains unclear how this reducing power is distributed. Methionine 102-112 gutter shaped root Mus musculus 36-39 28512249-5 2017 We also observed p62-dependent changes in Gcl, Gsr, Nqo1, and Srxn1, which were decreased by p62 attenuation and implicated in GSH production and utilization. Glutathione 127-130 gutter shaped root Mus musculus 47-50