PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31766320-3	2019	Stefin B-deficient mice were found more sensitive to lipopolysaccharide (LPS)-induced sepsis as a consequence of increased expression of caspase-11 and Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing (NLRP nflammasome activation and higher levels of mitochondrial reactive oxygen species (ROS).	Leucine	195-202	cystatin B	Mus musculus	0-8
31766320-3	2019	Stefin B-deficient mice were found more sensitive to lipopolysaccharide (LPS)-induced sepsis as a consequence of increased expression of caspase-11 and Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing (NLRP nflammasome activation and higher levels of mitochondrial reactive oxygen species (ROS).	Reactive Oxygen Species	307-330	cystatin B	Mus musculus	0-8
31766320-3	2019	Stefin B-deficient mice were found more sensitive to lipopolysaccharide (LPS)-induced sepsis as a consequence of increased expression of caspase-11 and Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing (NLRP nflammasome activation and higher levels of mitochondrial reactive oxygen species (ROS).	Reactive Oxygen Species	332-335	cystatin B	Mus musculus	0-8
26696823-7	2015	Upon LPS stimulation, stefin B was targeted into the mitochondria, and the lack of stefin B resulted in the increased destabilization of the mitochondrial membrane potential and mitochondrial superoxide generation.	Superoxides	192-202	cystatin B	Mus musculus	83-91
30019185-6	2018	CTSB inhibitor (CA-074) was used to suppress the expression of CSTB.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	16-22	cystatin B	Mus musculus	63-67
26908626-9	2016	Consistent with this notion, toxicity from ROS was attenuated in an NPC cell model by cystatin B over-expression or pharmacological inhibition of cathepsin B.	Reactive Oxygen Species	43-46	cystatin B	Mus musculus	86-96
28377970-4	2015	CSTB is an inhibitor of cysteine cathepsins, including cathepsin K, a key enzyme in bone resorption by osteoclasts.	Cysteine	24-32	cystatin B	Mus musculus	0-4
25270989-6	2014	Cystatin B deletion in TgCRND8 significantly reduces the number of GM2-positive granules and lowers the levels of GM2 and GM3 in lysosomes, decreases lipofuscin-related autofluorescence, and eliminates giant lipid-containing autolysosomes while increasing numbers of normal-sized autolysosomes/lysosomes with reduced content of undigested components.	gm2	67-70	cystatin B	Mus musculus	0-10
25270989-6	2014	Cystatin B deletion in TgCRND8 significantly reduces the number of GM2-positive granules and lowers the levels of GM2 and GM3 in lysosomes, decreases lipofuscin-related autofluorescence, and eliminates giant lipid-containing autolysosomes while increasing numbers of normal-sized autolysosomes/lysosomes with reduced content of undigested components.	gm2	114-117	cystatin B	Mus musculus	0-10
25270989-6	2014	Cystatin B deletion in TgCRND8 significantly reduces the number of GM2-positive granules and lowers the levels of GM2 and GM3 in lysosomes, decreases lipofuscin-related autofluorescence, and eliminates giant lipid-containing autolysosomes while increasing numbers of normal-sized autolysosomes/lysosomes with reduced content of undigested components.	Lipofuscin	150-160	cystatin B	Mus musculus	0-10
23049497-3	2012	Our previous results showed that thymocytes isolated from stefin B-deficient mice are more sensitive to apoptosis induced by the protein kinase C (PKC) inhibitor staurosporin (STS) than the wild-type control cells.	Staurosporine	162-174	cystatin B	Mus musculus	58-66
25288807-5	2014	Upon LPS stimulation, stefin B was targeted into the mitochondria, and the lack of stefin B resulted in the increased destabilization of mitochondrial membrane potential and mitochondrial superoxide generation.	Superoxides	188-198	cystatin B	Mus musculus	83-91
22538221-5	2012	In CSTB knockout mice, a progressive decrease in neocortex thickness was found, associated with a prevalent loss of GABA interneurons.	gamma-Aminobutyric Acid	116-120	cystatin B	Mus musculus	3-7
22140471-0	2011	Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB.	Pentylenetetrazole	20-23	cystatin B	Mus musculus	105-109
22140471-8	2011	Thus we aim to evaluate the effect of an increase in Cstb gene dosage on spontaneous epileptic activity and susceptibility to PTZ-induced seizure.	Pentylenetetrazole	126-129	cystatin B	Mus musculus	53-57
22140471-10	2011	We verified that increasing copy number of Cstb from Trisomy (Ts) to Tetrasomy (Tt) was driving overexpression of the gene in the brain, we checked transgenic animals for presence of locomotor activity and electroencephalogram (EEG) abnormalities characteristic of myoclonic epilepsy and we tested if those animals were prone to PTZ-induced seizure.	Pentylenetetrazole	329-332	cystatin B	Mus musculus	43-47
17188503-3	2007	Hippocampal slices prepared from CSTB-deficient mice were hyperexcitable, as they responded to afferent stimuli in CA1 with multiple population spikes and kainate perfusion provoked the appearance of epileptic-like activity earlier than in WT mice.	Kainic Acid	155-162	cystatin B	Mus musculus	33-37
17188503-4	2007	This hyperexcitability may depend on loss of inhibition, because the density of GABA-immunoreactive cells was reduced in the hippocampus of CSTB knockouts.	gamma-Aminobutyric Acid	80-84	cystatin B	Mus musculus	140-144
17188503-5	2007	In vivo, CSTB-deficient mice treated with kainate displayed increased susceptibility to seizures, with shorter latency to seizure onset and increased seizure severity compared with WT littermates.	Kainic Acid	42-49	cystatin B	Mus musculus	9-13
17054687-0	2006	Altered tryptophan metabolism in the brain of cystatin B-deficient mice: a model system for progressive myoclonus epilepsy.	Tryptophan	8-18	cystatin B	Mus musculus	46-56
17054687-7	2006	RESULTS: The Cstb-deficient mice had constitutively increased TRP, 5HT, and 5-hydroxyindole acetic acid (5HIAA) levels in the cerebral cortex and cerebellum and increased levels of KYN in the cerebellum.	Tryptophan	62-65	cystatin B	Mus musculus	13-17
17054687-7	2006	RESULTS: The Cstb-deficient mice had constitutively increased TRP, 5HT, and 5-hydroxyindole acetic acid (5HIAA) levels in the cerebral cortex and cerebellum and increased levels of KYN in the cerebellum.	Serotonin	67-70	cystatin B	Mus musculus	13-17
17054687-7	2006	RESULTS: The Cstb-deficient mice had constitutively increased TRP, 5HT, and 5-hydroxyindole acetic acid (5HIAA) levels in the cerebral cortex and cerebellum and increased levels of KYN in the cerebellum.	Hydroxyindoleacetic Acid	76-103	cystatin B	Mus musculus	13-17
17054687-7	2006	RESULTS: The Cstb-deficient mice had constitutively increased TRP, 5HT, and 5-hydroxyindole acetic acid (5HIAA) levels in the cerebral cortex and cerebellum and increased levels of KYN in the cerebellum.	Hydroxyindoleacetic Acid	105-110	cystatin B	Mus musculus	13-17
15987253-0	2005	Reduced serotonin and 3-hydroxyanthranilic acid levels in serum of cystatin B-deficient mice, a model system for progressive myoclonus epilepsy.	Serotonin	8-17	cystatin B	Mus musculus	67-77
15987253-0	2005	Reduced serotonin and 3-hydroxyanthranilic acid levels in serum of cystatin B-deficient mice, a model system for progressive myoclonus epilepsy.	3-Hydroxyanthranilic Acid	22-47	cystatin B	Mus musculus	67-77
15987253-3	2005	RESULTS: Reduced levels of 5-HT and KYN intermediate metabolite 3-hydroxyanthranilic acid were found in serum of CSTB-deficient mice.	Kynurenine	36-39	cystatin B	Mus musculus	113-117
15987253-3	2005	RESULTS: Reduced levels of 5-HT and KYN intermediate metabolite 3-hydroxyanthranilic acid were found in serum of CSTB-deficient mice.	3-Hydroxyanthranilic Acid	64-89	cystatin B	Mus musculus	113-117
17655504-0	2007	Cleavage of the myristoylated alanine-rich C kinase substrate (MARCKS) by cysteine cathepsins in cells and tissues of stefin B-deficient mice.	Cysteine	74-82	cystatin B	Mus musculus	118-126
15811333-0	2005	Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins.	Staurosporine	55-67	cystatin B	Mus musculus	17-25
15811333-3	2005	We have observed increased sensibility to STS-induced apoptosis in the thymocytes of stefin B-deficient mice.	Staurosporine	42-45	cystatin B	Mus musculus	85-93