PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
3207258-0	1988	Thymopoietin: a marker of the human nicotinic acetylcholine receptor.	Acetylcholine	46-59	thymopoietin	Homo sapiens	0-12
3622601-0	1987	Myasthenic sera recognize the human acetylcholine receptor bound to thymopoietin.	Acetylcholine	36-49	thymopoietin	Homo sapiens	68-80
3622601-1	1987	The thymic hormone, thymopoietin (Tpo), from human (HTpo), bovine (BTpo) and from synthetic (sHTpo) origins bound to the acetylcholine receptor (AChR) solubilized by Triton 1.5% from human muscle.	Acetylcholine	121-134	thymopoietin	Homo sapiens	20-32
3622601-1	1987	The thymic hormone, thymopoietin (Tpo), from human (HTpo), bovine (BTpo) and from synthetic (sHTpo) origins bound to the acetylcholine receptor (AChR) solubilized by Triton 1.5% from human muscle.	Acetylcholine	121-134	thymopoietin	Homo sapiens	34-37
31648495-1	2019	Objective: To investigate the effect of thymopoietin (TMPO) gene deleted by small interfering RNA (RNAi) on the proliferation and apoptosis of lung cancer cell A549 and its mechanism.	Thymopoietins	40-52	thymopoietin	Homo sapiens	54-58
2428508-1	1986	Thymopoietin-containing cells in the thymus were identified immunohistochemically using murine antiserum generated by immunization with synthetic Cys-thymopoietin28-39 (Cys-TP28-39).	Cysteine	146-149	thymopoietin	Homo sapiens	0-12
2428508-1	1986	Thymopoietin-containing cells in the thymus were identified immunohistochemically using murine antiserum generated by immunization with synthetic Cys-thymopoietin28-39 (Cys-TP28-39).	Cysteine	169-172	thymopoietin	Homo sapiens	0-12
3473468-5	1987	The pentapeptide active site of thymopoietin (residues 32-36) is constant between the human and bovine thymopoietins, but position 34 in the active site of splenin has changed from glutamic acid in bovine splenin to alanine in human splenin, accounting for the biological activity of the human but not the bovine splenin on the human T-cell line MOLT-4.	Alanine	216-223	thymopoietin	Homo sapiens	32-44
2994196-2	1985	The pentapeptide thymopentin (TP-5) Arg-Lys-Asp-Val-Tyr, corresponding to amino acids 32-36 of thymopoietin, appears to represent the active site of thymopoietin in that it has all the biological activities of the native hormone.	angiotensin pentapeptide	4-16	thymopoietin	Homo sapiens	95-107
2994196-2	1985	The pentapeptide thymopentin (TP-5) Arg-Lys-Asp-Val-Tyr, corresponding to amino acids 32-36 of thymopoietin, appears to represent the active site of thymopoietin in that it has all the biological activities of the native hormone.	angiotensin pentapeptide	4-16	thymopoietin	Homo sapiens	149-161
2994196-2	1985	The pentapeptide thymopentin (TP-5) Arg-Lys-Asp-Val-Tyr, corresponding to amino acids 32-36 of thymopoietin, appears to represent the active site of thymopoietin in that it has all the biological activities of the native hormone.	thymopentin (tp-5) arg-lys-asp-val-tyr	17-55	thymopoietin	Homo sapiens	95-107
2994196-2	1985	The pentapeptide thymopentin (TP-5) Arg-Lys-Asp-Val-Tyr, corresponding to amino acids 32-36 of thymopoietin, appears to represent the active site of thymopoietin in that it has all the biological activities of the native hormone.	thymopentin (tp-5) arg-lys-asp-val-tyr	17-55	thymopoietin	Homo sapiens	149-161
28902428-10	2018	One of these, a frameshift insertion that generates truncated LAP2, abrogated lamin-LAP2 binding, caused LAP2 mislocalization, altered endogenous lamin distribution, increased lipid droplet accumulation after oleic acid treatment in transfected cells, and led to cytoplasmic association with the ubiquitin-binding protein p62/SQSTM1.	Oleic Acid	209-219	thymopoietin	Homo sapiens	62-66
31190881-6	2019	The transcription of TMPO gene in human lung cancer was analyzed using Oncomine platform (www.oncomine.org) according to the standardized procedures described previously.	oncomine	71-79	thymopoietin	Homo sapiens	21-25
31190881-6	2019	The transcription of TMPO gene in human lung cancer was analyzed using Oncomine platform (www.oncomine.org) according to the standardized procedures described previously.	oncomine	94-102	thymopoietin	Homo sapiens	21-25
31516562-0	2019	Downregulation of thymopoietin by miR-139-5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma.	mir-139-5p	34-44	thymopoietin	Homo sapiens	18-30
19662724-3	2009	Sodium 2,4,6-trimethylbenzoyl-phenylphosphine oxide (TMPO-Na = APO-Na) was synthesized in 67.1% yield and identified by 1H NMR.	sodium 2,4,6-trimethylbenzoyl-phenylphosphine oxide	0-51	thymopoietin	Homo sapiens	53-57
28702476-3	2017	We constructed two different tetracycline (tet)-on-based regulatable HSV vectors, one expressing NT-3 and the other expressing IL-10, in which the transactivator expression in the tet-on system was under the control of HSV latency-associated promoter 2 (LAP-2), and expression of the transgene was controlled by doxycycline (DOX).	Tetracycline	43-46	thymopoietin	Homo sapiens	254-259
19702786-1	2009	BACKGROUND AND PURPOSE: In previous studies investigating cross-talk of signalling between prostaglandin (PG)E(2) receptor (EP) and the TPalpha and TPbeta isoforms of the human thromboxane (TX)A(2) receptor (TP), 17-phenyl trinor PGE(2)-induced desensitization of TP receptor signalling through activation of the AH6809 and SC19220-sensitive EP(1) subtype of the EP receptor family, in a cell-specific manner.	Prostaglandins	91-104	thymopoietin	Homo sapiens	136-206
19702786-1	2009	BACKGROUND AND PURPOSE: In previous studies investigating cross-talk of signalling between prostaglandin (PG)E(2) receptor (EP) and the TPalpha and TPbeta isoforms of the human thromboxane (TX)A(2) receptor (TP), 17-phenyl trinor PGE(2)-induced desensitization of TP receptor signalling through activation of the AH6809 and SC19220-sensitive EP(1) subtype of the EP receptor family, in a cell-specific manner.	Prostaglandins E	230-233	thymopoietin	Homo sapiens	136-206
21357687-1	2011	In humans, thromboxane (TX) A(2) signals through the TPalpha and TPbeta isoforms of the TXA(2) receptor or TP.	Thromboxanes	11-22	thymopoietin	Homo sapiens	53-103
21357687-1	2011	In humans, thromboxane (TX) A(2) signals through the TPalpha and TPbeta isoforms of the TXA(2) receptor or TP.	tx) a	24-29	thymopoietin	Homo sapiens	53-103
19662724-3	2009	Sodium 2,4,6-trimethylbenzoyl-phenylphosphine oxide (TMPO-Na = APO-Na) was synthesized in 67.1% yield and identified by 1H NMR.	apo-na	63-69	thymopoietin	Homo sapiens	53-57
19662724-3	2009	Sodium 2,4,6-trimethylbenzoyl-phenylphosphine oxide (TMPO-Na = APO-Na) was synthesized in 67.1% yield and identified by 1H NMR.	Hydrogen	120-122	thymopoietin	Homo sapiens	53-57
19166305-4	2009	When UCl4 is reacted with 1 equiv (PNP)K (6) in the presence of THF, trimethylphosphine oxide (TMPO), or triphenylphosphineoxide (TPPO), the tetravalent halide complexes (PNP)UCl3(THF) (9), (PNP)UCl3(TMPO)2 (10), and (PNP)UCl3(TPPO) (11), respectively, are formed in excellent yields.	halide	153-159	thymopoietin	Homo sapiens	200-204
17425630-7	2007	The binding of flavonoids to TP in platelets, human myometrium and TPalpha- and TPbeta-transfected HEK 293T cells was explored using binding assays and the TP antagonist (3)H-SQ29548.	Flavonoids	15-25	thymopoietin	Homo sapiens	67-86
18502100-1	2008	In humans, thromboxane (TX) A(2) signals through the TPalpha and TPbeta isoforms of the TXA(2) receptor that exhibit common and distinct roles.	thromboxane (tx) a	11-29	thymopoietin	Homo sapiens	53-103
19071607-2	2007	The (1)O(2) produced in the reaction was further characterized and confirmed by (i) chemical trapping of (1)O(2) with 9,10-diphenylanthracene (DPA), the corresponding endoperoxide was detected by HPLC and (ii) spin trapping of (1)O(2) with 2,2,6,6-tetramethyl-4-piperidinol (TMP-OH), the corresponding free radical of TMP-OH oxide (TMPO) was detected by electron spin resonance (ESR) spectroscopy.	9,10-diphenylanthracene	118-141	thymopoietin	Homo sapiens	332-336
17362923-9	2007	Using RT-PCR, we found that human umbilical vein rings with or without endothelium express the prostanoid TP(alpha), but not the prostanoid TP(beta) receptor isoform.	Prostaglandins	95-105	thymopoietin	Homo sapiens	106-115
17362923-11	2007	Collectively, present results demonstrate that prostanoid TP(alpha) is the major receptor isoform localized on smooth muscle cells which participate in both direct vasoconstriction and potentiating effects of U-46619 on adrenaline contractions in human umbilical vein.	Prostaglandins	47-57	thymopoietin	Homo sapiens	58-67
17362923-11	2007	Collectively, present results demonstrate that prostanoid TP(alpha) is the major receptor isoform localized on smooth muscle cells which participate in both direct vasoconstriction and potentiating effects of U-46619 on adrenaline contractions in human umbilical vein.	Uranium	209-210	thymopoietin	Homo sapiens	58-67
19071607-2	2007	The (1)O(2) produced in the reaction was further characterized and confirmed by (i) chemical trapping of (1)O(2) with 9,10-diphenylanthracene (DPA), the corresponding endoperoxide was detected by HPLC and (ii) spin trapping of (1)O(2) with 2,2,6,6-tetramethyl-4-piperidinol (TMP-OH), the corresponding free radical of TMP-OH oxide (TMPO) was detected by electron spin resonance (ESR) spectroscopy.	9,10-diphenylanthracene	143-146	thymopoietin	Homo sapiens	332-336
19071607-2	2007	The (1)O(2) produced in the reaction was further characterized and confirmed by (i) chemical trapping of (1)O(2) with 9,10-diphenylanthracene (DPA), the corresponding endoperoxide was detected by HPLC and (ii) spin trapping of (1)O(2) with 2,2,6,6-tetramethyl-4-piperidinol (TMP-OH), the corresponding free radical of TMP-OH oxide (TMPO) was detected by electron spin resonance (ESR) spectroscopy.	1-hexadecyl-2-acetyl-glycero-3-phosphocholine	4-8	thymopoietin	Homo sapiens	332-336
19071607-2	2007	The (1)O(2) produced in the reaction was further characterized and confirmed by (i) chemical trapping of (1)O(2) with 9,10-diphenylanthracene (DPA), the corresponding endoperoxide was detected by HPLC and (ii) spin trapping of (1)O(2) with 2,2,6,6-tetramethyl-4-piperidinol (TMP-OH), the corresponding free radical of TMP-OH oxide (TMPO) was detected by electron spin resonance (ESR) spectroscopy.	lastar A	240-273	thymopoietin	Homo sapiens	332-336
19071607-2	2007	The (1)O(2) produced in the reaction was further characterized and confirmed by (i) chemical trapping of (1)O(2) with 9,10-diphenylanthracene (DPA), the corresponding endoperoxide was detected by HPLC and (ii) spin trapping of (1)O(2) with 2,2,6,6-tetramethyl-4-piperidinol (TMP-OH), the corresponding free radical of TMP-OH oxide (TMPO) was detected by electron spin resonance (ESR) spectroscopy.	tmp-oh	275-281	thymopoietin	Homo sapiens	332-336
19071607-2	2007	The (1)O(2) produced in the reaction was further characterized and confirmed by (i) chemical trapping of (1)O(2) with 9,10-diphenylanthracene (DPA), the corresponding endoperoxide was detected by HPLC and (ii) spin trapping of (1)O(2) with 2,2,6,6-tetramethyl-4-piperidinol (TMP-OH), the corresponding free radical of TMP-OH oxide (TMPO) was detected by electron spin resonance (ESR) spectroscopy.	tmp-oh oxide	318-330	thymopoietin	Homo sapiens	332-336
1493543-1	1992	Thymopoietin, a polypeptide hormone isolated from thymus and involved in immune function, potently inhibited [125I]alpha-bungarotoxin binding to neonatal muscle cells in culture (IC50 = 3.8 nM) and blocked carbachol-stimulated 22Na uptake with an IC50 of 1.9 +/- 0.2 nM and 23 +/- 7 nM at a half-maximal and maximal concentration of carbachol, respectively.	Carbachol	206-215	thymopoietin	Homo sapiens	0-12
11829587-1	2002	The interactions of Bronsted acid sites of H-Y (FAU) with perdeuterated trimethylphosphine oxide (TMPO-d9) are studied with a set of high-resolution solid-state NMR experiments.	bronsted acid	20-33	thymopoietin	Homo sapiens	98-102
11829587-1	2002	The interactions of Bronsted acid sites of H-Y (FAU) with perdeuterated trimethylphosphine oxide (TMPO-d9) are studied with a set of high-resolution solid-state NMR experiments.	trimethylphosphine oxide	72-96	thymopoietin	Homo sapiens	98-102
11829587-2	2002	Double- and triple-resonance MAS NMR techniques (such as CP, TRAPDOR, and REDOR) verify that the lines in the 31P MAS NMR spectrum are indeed from TMPO interacting with Bronsted acid sites.	bronsted acid	169-182	thymopoietin	Homo sapiens	147-151
15471868-8	2004	However, despite inefficient binding of iPE(2)III to either the IP or TPalpha, expressed alone or in combination, robust cAMP generation was evident in IP/TPalpha-HEK, suggesting the formation of an alternative receptor site.	ipe	40-43	thymopoietin	Homo sapiens	64-77
11034905-2	2000	Using various cell systems, including Jurkat, HL-60, and HeLa cells, and different death-inducing agents, such as anti-Fas antibody, topoisomerase inhibitors, and staurosporine, we found that LAP2 alpha was cleaved during apoptosis as rapidly as lamin B in a caspase-dependent manner yielding stable N- and C-terminal fragments of approximately 50 and 28 kDa, respectively.	Staurosporine	163-176	thymopoietin	Homo sapiens	192-196
11055976-1	2000	Thromboxane A(2) (TxA(2)) causes platelet aggregation, vasoconstriction, and inhibition of endothelial cell (EC) migration and prevents vascular tube formation via its specific receptors (TP), of which there are two isoforms (TPalpha and TPbeta), both expressed in human ECs.	thromboxane a	0-13	thymopoietin	Homo sapiens	226-244
11055976-1	2000	Thromboxane A(2) (TxA(2)) causes platelet aggregation, vasoconstriction, and inhibition of endothelial cell (EC) migration and prevents vascular tube formation via its specific receptors (TP), of which there are two isoforms (TPalpha and TPbeta), both expressed in human ECs.	txa	18-21	thymopoietin	Homo sapiens	226-244
1493543-1	1992	Thymopoietin, a polypeptide hormone isolated from thymus and involved in immune function, potently inhibited [125I]alpha-bungarotoxin binding to neonatal muscle cells in culture (IC50 = 3.8 nM) and blocked carbachol-stimulated 22Na uptake with an IC50 of 1.9 +/- 0.2 nM and 23 +/- 7 nM at a half-maximal and maximal concentration of carbachol, respectively.	Carbachol	333-342	thymopoietin	Homo sapiens	0-12
1493543-4	1992	Thymopoietin did not appreciably alter myotube morphology on its own; however, it prevented the effects of nicotine and carbachol on muscle cell morphology at concentrations (1-10 nM) which corresponded well to those with which thymopoietin interacted at the receptor.	Nicotine	107-115	thymopoietin	Homo sapiens	0-12
1493543-4	1992	Thymopoietin did not appreciably alter myotube morphology on its own; however, it prevented the effects of nicotine and carbachol on muscle cell morphology at concentrations (1-10 nM) which corresponded well to those with which thymopoietin interacted at the receptor.	Carbachol	120-129	thymopoietin	Homo sapiens	0-12
1701215-4	1990	TPO and Bgt also share the capacity for high affinity interaction with muscle-type nAcChoR, which are expressed as high affinity binding sites for radioiodinated Bgt or tritium-labeled acetylcholine by cells of the TE671/RD human clone or the BC3H-1 mouse muscle cell line or on membrane preparations from Torpedo electroplax.	nacchor	83-90	thymopoietin	Homo sapiens	0-3
1848710-5	1991	Binding of 125I-labeled thymopoietin was displaced not only by unlabeled thymopoietin but also by alpha-BGT and the nicotinic receptor ligands d-tubocurarine and nicotine; various other receptor ligands (muscarinic, adrenergic, and dopaminergic) did not affect binding of 125I-labeled thymopoietin.	Iodine-125	11-15	thymopoietin	Homo sapiens	24-36
1848710-5	1991	Binding of 125I-labeled thymopoietin was displaced not only by unlabeled thymopoietin but also by alpha-BGT and the nicotinic receptor ligands d-tubocurarine and nicotine; various other receptor ligands (muscarinic, adrenergic, and dopaminergic) did not affect binding of 125I-labeled thymopoietin.	Iodine-125	11-15	thymopoietin	Homo sapiens	73-85
1848710-5	1991	Binding of 125I-labeled thymopoietin was displaced not only by unlabeled thymopoietin but also by alpha-BGT and the nicotinic receptor ligands d-tubocurarine and nicotine; various other receptor ligands (muscarinic, adrenergic, and dopaminergic) did not affect binding of 125I-labeled thymopoietin.	Iodine-125	11-15	thymopoietin	Homo sapiens	73-85
1848710-5	1991	Binding of 125I-labeled thymopoietin was displaced not only by unlabeled thymopoietin but also by alpha-BGT and the nicotinic receptor ligands d-tubocurarine and nicotine; various other receptor ligands (muscarinic, adrenergic, and dopaminergic) did not affect binding of 125I-labeled thymopoietin.	Tubocurarine	143-157	thymopoietin	Homo sapiens	24-36
1848710-5	1991	Binding of 125I-labeled thymopoietin was displaced not only by unlabeled thymopoietin but also by alpha-BGT and the nicotinic receptor ligands d-tubocurarine and nicotine; various other receptor ligands (muscarinic, adrenergic, and dopaminergic) did not affect binding of 125I-labeled thymopoietin.	Nicotine	162-170	thymopoietin	Homo sapiens	24-36
1848710-5	1991	Binding of 125I-labeled thymopoietin was displaced not only by unlabeled thymopoietin but also by alpha-BGT and the nicotinic receptor ligands d-tubocurarine and nicotine; various other receptor ligands (muscarinic, adrenergic, and dopaminergic) did not affect binding of 125I-labeled thymopoietin.	Iodine-125	272-276	thymopoietin	Homo sapiens	24-36
1701215-4	1990	TPO and Bgt also share the capacity for high affinity interaction with muscle-type nAcChoR, which are expressed as high affinity binding sites for radioiodinated Bgt or tritium-labeled acetylcholine by cells of the TE671/RD human clone or the BC3H-1 mouse muscle cell line or on membrane preparations from Torpedo electroplax.	Tritium	169-176	thymopoietin	Homo sapiens	0-3
1701215-4	1990	TPO and Bgt also share the capacity for high affinity interaction with muscle-type nAcChoR, which are expressed as high affinity binding sites for radioiodinated Bgt or tritium-labeled acetylcholine by cells of the TE671/RD human clone or the BC3H-1 mouse muscle cell line or on membrane preparations from Torpedo electroplax.	Acetylcholine	185-198	thymopoietin	Homo sapiens	0-3
1701215-5	1990	TPO and Bgt act acutely as high affinity antagonists of muscle-type nAcChoR functional responses, which are measured using an isotopic rubidium ion efflux assay, on TE671/RD or BC3H-1 cells.	Rubidium	135-143	thymopoietin	Homo sapiens	0-3
2158125-3	1990	We synthesized a series of penta- and tetrapeptide analogs of amino acids 32-36 of human thymopoietin and thysplenin, and now show that distinct patterns of activity can be obtained in these small peptides, with selectivity for cyclic GMP elevation in MOLT-4 alone or CEM alone.	PENTA	27-32	thymopoietin	Homo sapiens	89-101
2158125-3	1990	We synthesized a series of penta- and tetrapeptide analogs of amino acids 32-36 of human thymopoietin and thysplenin, and now show that distinct patterns of activity can be obtained in these small peptides, with selectivity for cyclic GMP elevation in MOLT-4 alone or CEM alone.	2-chloroethyl methyl sulfide	268-271	thymopoietin	Homo sapiens	89-101