PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28386336-0	2017	Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP.	Celecoxib	0-9	BRCA2 and CDKN1A interacting protein	Homo sapiens	103-108
28386336-6	2017	Treatment with celecoxib significantly increased BCCIP expression in COX-2 negative HCT116 cells.	Celecoxib	15-24	BRCA2 and CDKN1A interacting protein	Homo sapiens	49-54
28386336-7	2017	Knockdown of BCCIP obviously abrogated the enhanced radiosensitivity of HCT116 cells induced by celecoxib.	Celecoxib	96-105	BRCA2 and CDKN1A interacting protein	Homo sapiens	13-18
28386336-11	2017	Celecoxib affects the functions of p53 and inhibits the recovery from the irradiation-induced injury by up-regulating the expression of BCCIP, and subsequently regulates the expressions of genes such as p21 and Cyclin B1 to enhance the radiosensitivity of HCT116 cells in a COX-2 independent manner.	Celecoxib	0-9	BRCA2 and CDKN1A interacting protein	Homo sapiens	136-141
27694622-0	2017	The beta-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing.	Adenosine Diphosphate	35-38	BRCA2 and CDKN1A interacting protein	Homo sapiens	20-25
27995408-10	2017	In addition, BCCIP beta downregulation by silencing RNA significantly decreased the rate of colony formation, alleviated cellular apoptosis and increased the chemosensitivity of cisplatin.	Cisplatin	178-187	BRCA2 and CDKN1A interacting protein	Homo sapiens	13-23
27694622-10	2017	Notably, this stimulatory effect is not the result of RAD51 nucleoprotein filament stabilization; rather, we demonstrate that BCCIPbeta induces a conformational change within the RAD51 filament that promotes release of ADP to help maintain an active presynaptic filament.	Adenosine Diphosphate	219-222	BRCA2 and CDKN1A interacting protein	Homo sapiens	126-135
32979005-4	2021	Unexpectedly, MM2-48 covalently targets a functional cysteine in BCCIP, a BRCA2 and CDKN1A-interacting protein, and significantly inhibits DNA damage repair.	Cysteine	53-61	BRCA2 and CDKN1A interacting protein	Homo sapiens	65-70
33452718-8	2021	Moreover, both acetyl-CoA and substrate-binding grooves are altered in BCCIP.	Acetyl Coenzyme A	15-25	BRCA2 and CDKN1A interacting protein	Homo sapiens	71-76
11313963-4	2001	Human BCCIP represents a family of proteins that are evolutionarily conserved, and contain three distinct domains: an N-terminus acidic domain (NAD) of 30-60 amino acids, an internal conserved domain (ICD) of 180-220 amino acids, and a C-terminus variable domain (CVD) of 30-60 amino acids.	nadide	144-147	BRCA2 and CDKN1A interacting protein	Homo sapiens	6-11