PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
10924811-0	2000	Differential effects of antisense oligodeoxynucleotides directed against g(zalpha) and g(oalpha) on antinociception produced by spinal opioid and alpha(2) adrenergic receptor agonists.	Oligodeoxyribonucleotides	34-55	guanine nucleotide binding protein, alpha O	Mus musculus	87-96
10924811-12	2000	Pretreatment with antisense ODN to G(oalpha) attenuated both morphine and clonidine induced antinociception and did not affect synergism between the agonists.	Morphine	61-69	guanine nucleotide binding protein, alpha O	Mus musculus	35-44
10924811-12	2000	Pretreatment with antisense ODN to G(oalpha) attenuated both morphine and clonidine induced antinociception and did not affect synergism between the agonists.	Clonidine	74-83	guanine nucleotide binding protein, alpha O	Mus musculus	35-44
10608281-0	1999	Myr+-Gi2 alpha and Go alpha subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice.	Clonidine	70-79	guanine nucleotide binding protein, alpha O	Mus musculus	19-27
10588714-6	1999	ISO stimulation of endoderm formation of F9 stem cells expressing the chimeric receptor was blocked by pertussis toxin and by oligodeoxynucleotide antisense to Galphao, Galphat2, and Gbeta2.	Isoproterenol	0-3	guanine nucleotide binding protein, alpha O	Mus musculus	160-167
10588714-6	1999	ISO stimulation of endoderm formation of F9 stem cells expressing the chimeric receptor was blocked by pertussis toxin and by oligodeoxynucleotide antisense to Galphao, Galphat2, and Gbeta2.	Oligodeoxyribonucleotides	126-146	guanine nucleotide binding protein, alpha O	Mus musculus	160-167
10883729-1	2000	The pseudoguaianolide sesquiterpene lactones 4-alpha-O-acetyl-pseudoguaian-6beta-olide (1), hymenin (2), ambrosanolide (3), tetraneurin A (4), parthenin (5), hysterin (6) and confertdiolide (7) were evaluated for their ability to affect the inflammation responses induced by different agents.	pseudoguaianolide	4-21	guanine nucleotide binding protein, alpha O	Mus musculus	47-54
10669512-2	2000	In CA3 neurons from Galpha(o)(-/-) mice, 2-chloro-adenosine and the GABA(B)-receptor agonist baclofen activated inwardly rectifying K(+) currents and inhibited voltage-dependent Ca(2+) currents just as effectively as in Galpha(o)(+/+) littermates.	2-Chloroadenosine	41-59	guanine nucleotide binding protein, alpha O	Mus musculus	20-29
10669512-2	2000	In CA3 neurons from Galpha(o)(-/-) mice, 2-chloro-adenosine and the GABA(B)-receptor agonist baclofen activated inwardly rectifying K(+) currents and inhibited voltage-dependent Ca(2+) currents just as effectively as in Galpha(o)(+/+) littermates.	2-Chloroadenosine	41-59	guanine nucleotide binding protein, alpha O	Mus musculus	220-229
10669512-2	2000	In CA3 neurons from Galpha(o)(-/-) mice, 2-chloro-adenosine and the GABA(B)-receptor agonist baclofen activated inwardly rectifying K(+) currents and inhibited voltage-dependent Ca(2+) currents just as effectively as in Galpha(o)(+/+) littermates.	Baclofen	93-101	guanine nucleotide binding protein, alpha O	Mus musculus	20-29
10669512-2	2000	In CA3 neurons from Galpha(o)(-/-) mice, 2-chloro-adenosine and the GABA(B)-receptor agonist baclofen activated inwardly rectifying K(+) currents and inhibited voltage-dependent Ca(2+) currents just as effectively as in Galpha(o)(+/+) littermates.	Baclofen	93-101	guanine nucleotide binding protein, alpha O	Mus musculus	220-229
10669512-4	2000	For example, recovery from 2-chloro-adenosine inhibition of calcium current was more than fourfold slower in neurons from Galpha(o)(-/-) mice [time constant of 12.0 +/- 0.8 (SE) s] than in neurons from Galpha(o)(+/+) mice (time constant of 2.6 +/- 0.2 s).	2-Chloroadenosine	27-45	guanine nucleotide binding protein, alpha O	Mus musculus	122-131
10669512-4	2000	For example, recovery from 2-chloro-adenosine inhibition of calcium current was more than fourfold slower in neurons from Galpha(o)(-/-) mice [time constant of 12.0 +/- 0.8 (SE) s] than in neurons from Galpha(o)(+/+) mice (time constant of 2.6 +/- 0.2 s).	Calcium	60-67	guanine nucleotide binding protein, alpha O	Mus musculus	122-131
10669512-7	2000	In neurons lacking Galpha(o), some inhibition of Ca(2+) currents by baclofen remained after NEM treatment, whereas baclofen activation of K(+) currents and both effects of 2-chloro-adenosine were abolished.	2-Chloroadenosine	172-190	guanine nucleotide binding protein, alpha O	Mus musculus	19-28
9279808-9	1997	Injection of antisense (or sense) oligonucleotides against G alpha i1, G alpha i3 and G alpha O (common) had no effect.	Oligonucleotides	34-50	guanine nucleotide binding protein, alpha O	Mus musculus	86-95
10559239-4	1999	Primitive endoderm formation stimulated by Wnt-8 acting on the rat Frizzled-1 receptor was blocked by treatment with pertussis toxin by depletion of either Galpha(o) or Galpha(q) via antisense oligodeoxynucleotides, as well as by inhibitors of protein kinase C (bisindoylmaleimide) and of mitogen-activated protein kinase kinase (PD98059).	Oligodeoxyribonucleotides	193-214	guanine nucleotide binding protein, alpha O	Mus musculus	156-165
10559239-4	1999	Primitive endoderm formation stimulated by Wnt-8 acting on the rat Frizzled-1 receptor was blocked by treatment with pertussis toxin by depletion of either Galpha(o) or Galpha(q) via antisense oligodeoxynucleotides, as well as by inhibitors of protein kinase C (bisindoylmaleimide) and of mitogen-activated protein kinase kinase (PD98059).	bisindolylmaleimide iv	262-280	guanine nucleotide binding protein, alpha O	Mus musculus	156-165
10559239-4	1999	Primitive endoderm formation stimulated by Wnt-8 acting on the rat Frizzled-1 receptor was blocked by treatment with pertussis toxin by depletion of either Galpha(o) or Galpha(q) via antisense oligodeoxynucleotides, as well as by inhibitors of protein kinase C (bisindoylmaleimide) and of mitogen-activated protein kinase kinase (PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	330-337	guanine nucleotide binding protein, alpha O	Mus musculus	156-165
10196137-11	1999	Galphao and Pcp2 binding was confirmed in vitro using glutathione S-transferase-Pcp2 fusion proteins and in vitro translated [35S]methionine-labeled Galphao.	Glutathione	54-65	guanine nucleotide binding protein, alpha O	Mus musculus	0-7
10196137-11	1999	Galphao and Pcp2 binding was confirmed in vitro using glutathione S-transferase-Pcp2 fusion proteins and in vitro translated [35S]methionine-labeled Galphao.	Sulfur-35	126-129	guanine nucleotide binding protein, alpha O	Mus musculus	0-7
10196137-11	1999	Galphao and Pcp2 binding was confirmed in vitro using glutathione S-transferase-Pcp2 fusion proteins and in vitro translated [35S]methionine-labeled Galphao.	Methionine	130-140	guanine nucleotide binding protein, alpha O	Mus musculus	0-7
10196137-11	1999	Galphao and Pcp2 binding was confirmed in vitro using glutathione S-transferase-Pcp2 fusion proteins and in vitro translated [35S]methionine-labeled Galphao.	Methionine	130-140	guanine nucleotide binding protein, alpha O	Mus musculus	149-156
10196137-14	1999	Pcp2 stimulates GDP release from Galphao more than 5-fold without affecting kcat.	Guanosine Diphosphate	16-19	guanine nucleotide binding protein, alpha O	Mus musculus	33-40
1906458-4	1991	In this report, using biosynthetic labeling with [35S]methionine and specific quantitative immunoprecipitation with a polyclonal antibody raised against the purified Go alpha protein, we have determined 1) the degradation rate of total Go alpha (sum of the two isoforms) in differentiated as well as in undifferentiated neuroblastoma cells and in cerebellar granule cells, 2) the degradation rates of each isoform in differentiated neuroblastoma cells.	Sulfur-35	50-53	guanine nucleotide binding protein, alpha O	Mus musculus	166-174
8700136-2	1996	Intracerebroventricular administration of oligodeoxynucleotides targeting Gi alpha 2, G(o) alpha, and Gs alpha block supraspinal mu-opioid analgesia, whereas Gi alpha 2 and Gx/z alpha antisense probes block spinal mu analgesia.	Oligodeoxyribonucleotides	42-63	guanine nucleotide binding protein, alpha O	Mus musculus	74-96
7748334-4	1993	Pretreatment of NG108-15 cells with ethanol (200 mM, 48h) reduced membrane levels of Gs alpha and Gi alpha but increased Go alpha expression.	Ethanol	36-43	guanine nucleotide binding protein, alpha O	Mus musculus	121-129
7748334-4	1993	Pretreatment of NG108-15 cells with ethanol (200 mM, 48h) reduced membrane levels of Gs alpha and Gi alpha but increased Go alpha expression.	48H	53-56	guanine nucleotide binding protein, alpha O	Mus musculus	121-129
8381506-3	1993	Here we investigated the effects of chronic ethanol treatment on the expression of Gs alpha, Gi alpha, and Go alpha, as well as cAMP signal transduction, in NG108-15 cells and further examined the role of adenosine in mediating these effects.	Ethanol	44-51	guanine nucleotide binding protein, alpha O	Mus musculus	107-115
8381506-4	1993	Pretreatment of NG108-15 cells with 200 mM ethanol for 2 days reduced membrane levels of Gs alpha and Gi alpha and increased those of Go alpha.	Ethanol	43-50	guanine nucleotide binding protein, alpha O	Mus musculus	134-142
8095554-0	1993	D2-dopaminergic agonist quinpirole and 8-bromo-cAMP have opposite effects on Go alpha GTP-binding protein mRNA without changing D2 dopamine receptor mRNA levels in striatal neurones in primary culture.	Quinpirole	24-34	guanine nucleotide binding protein, alpha O	Mus musculus	77-85
8095554-0	1993	D2-dopaminergic agonist quinpirole and 8-bromo-cAMP have opposite effects on Go alpha GTP-binding protein mRNA without changing D2 dopamine receptor mRNA levels in striatal neurones in primary culture.	8-Bromo Cyclic Adenosine Monophosphate	39-51	guanine nucleotide binding protein, alpha O	Mus musculus	77-85
8095554-3	1993	When the preparation was treated with the D2-DA agonist quinpirole (5-15 hrs, 10(-4) M), which decreases cAMP in these neurones, the levels of Go alpha mRNAs were enhanced whereas that of the D2 mRNA remained unchanged.	d2-da	42-47	guanine nucleotide binding protein, alpha O	Mus musculus	143-151
8095554-3	1993	When the preparation was treated with the D2-DA agonist quinpirole (5-15 hrs, 10(-4) M), which decreases cAMP in these neurones, the levels of Go alpha mRNAs were enhanced whereas that of the D2 mRNA remained unchanged.	Quinpirole	56-66	guanine nucleotide binding protein, alpha O	Mus musculus	143-151
8095554-4	1993	Conversely, the Go alpha mRNAs, but not the D2 mRNA, decreased when the neurones were exposed to 8-bromo-cAMP (16 hrs, 10(-6) M).	8-Bromo Cyclic Adenosine Monophosphate	97-109	guanine nucleotide binding protein, alpha O	Mus musculus	16-24
8095554-5	1993	It is concluded that, in these experimental conditions where neurones have not yet established their connexions, the longterm regulation of the membrane transmission of D2-DA signal might implicate mainly the Go alpha encoding gene.	d2-da	169-174	guanine nucleotide binding protein, alpha O	Mus musculus	209-217
1906458-4	1991	In this report, using biosynthetic labeling with [35S]methionine and specific quantitative immunoprecipitation with a polyclonal antibody raised against the purified Go alpha protein, we have determined 1) the degradation rate of total Go alpha (sum of the two isoforms) in differentiated as well as in undifferentiated neuroblastoma cells and in cerebellar granule cells, 2) the degradation rates of each isoform in differentiated neuroblastoma cells.	Methionine	54-64	guanine nucleotide binding protein, alpha O	Mus musculus	166-174
2118945-0	1990	Pretreatment of mouse striatal neurons in primary culture with 17 beta-estradiol enhances the pertussis toxin-catalyzed ADP-ribosylation of G alpha o,i protein subunits.	Estradiol	63-80	guanine nucleotide binding protein, alpha O	Mus musculus	140-149
1848817-4	1991	Treatment of cells with 0.1 microM 8-bromoadenosine 3",5"-(cyclic)phosphate (BrcAMP) for 16 h, or with 0.1 mM BrcAMP for 5 min, mimicked the effect of cholera toxin on the ADP-ribosylation of Go alpha and Gi alpha in vitro.	8-bromoadenosine 3",5"-(cyclic)phosphate	35-75	guanine nucleotide binding protein, alpha O	Mus musculus	192-200
1848817-4	1991	Treatment of cells with 0.1 microM 8-bromoadenosine 3",5"-(cyclic)phosphate (BrcAMP) for 16 h, or with 0.1 mM BrcAMP for 5 min, mimicked the effect of cholera toxin on the ADP-ribosylation of Go alpha and Gi alpha in vitro.	8-Bromo Cyclic Adenosine Monophosphate	77-83	guanine nucleotide binding protein, alpha O	Mus musculus	192-200
1848817-4	1991	Treatment of cells with 0.1 microM 8-bromoadenosine 3",5"-(cyclic)phosphate (BrcAMP) for 16 h, or with 0.1 mM BrcAMP for 5 min, mimicked the effect of cholera toxin on the ADP-ribosylation of Go alpha and Gi alpha in vitro.	8-Bromo Cyclic Adenosine Monophosphate	110-116	guanine nucleotide binding protein, alpha O	Mus musculus	192-200
2118945-1	1990	Pretreatment of striatal neurons from mouse embryos in primary culture with 17 beta-estradiol (10(-9) M, 24 h) enhanced the ADP-ribosylation of G alpha o,i proteins catalyzed by pertussis toxin (PTX).	Estradiol	76-93	guanine nucleotide binding protein, alpha O	Mus musculus	144-153
2118945-1	1990	Pretreatment of striatal neurons from mouse embryos in primary culture with 17 beta-estradiol (10(-9) M, 24 h) enhanced the ADP-ribosylation of G alpha o,i proteins catalyzed by pertussis toxin (PTX).	Adenosine Diphosphate	124-127	guanine nucleotide binding protein, alpha O	Mus musculus	144-153
2118945-3	1990	Thus, 17 beta-estradiol should induce a qualitative modification of these G proteins, perhaps by stabilizing the association of the heterotrimers G alpha o,i beta gamma, which are the targets of PTX.	Estradiol	6-23	guanine nucleotide binding protein, alpha O	Mus musculus	146-155
2118945-5	1990	In addition, PTX pretreatment, which is known to uncouple receptors associated with Go,i proteins and thus to impair the dissociation of the heterotrimers G alpha o,i beta gamma, mimicks the effects of the steroid on the responses of adenylate cyclase to inhibitory and stimulatory agonists.	Steroids	206-213	guanine nucleotide binding protein, alpha O	Mus musculus	155-164
2107277-5	1990	Both Go alpha isoforms have similar sizes on sodium dodecyl sulfate-polyacrylamide gels, are recognized by polyclonal antibodies to bovine brain Go alpha, are ADP-ribosylated by PTX, and are covalently myristylated in whole N1E-115 cells.	Adenosine Diphosphate	159-162	guanine nucleotide binding protein, alpha O	Mus musculus	5-13
3123616-7	1988	32P-ADP-ribosylation of the same neuronal and glial cell membranes with pertussis toxin indicated the presence of at least 3 substrates related to Go alpha, Gi alpha (41 kDa), and a 40 kDa protein.	32p-adp	0-7	guanine nucleotide binding protein, alpha O	Mus musculus	147-155
2107277-5	1990	Both Go alpha isoforms have similar sizes on sodium dodecyl sulfate-polyacrylamide gels, are recognized by polyclonal antibodies to bovine brain Go alpha, are ADP-ribosylated by PTX, and are covalently myristylated in whole N1E-115 cells.	Sodium Dodecyl Sulfate	45-67	guanine nucleotide binding protein, alpha O	Mus musculus	5-13
2107277-5	1990	Both Go alpha isoforms have similar sizes on sodium dodecyl sulfate-polyacrylamide gels, are recognized by polyclonal antibodies to bovine brain Go alpha, are ADP-ribosylated by PTX, and are covalently myristylated in whole N1E-115 cells.	polyacrylamide	68-82	guanine nucleotide binding protein, alpha O	Mus musculus	5-13
1963397-5	1990	Results of ADP-ribosylation experiments with cholera toxin or pertussis toxin and of immunoblot experiments with anti-G alpha o and anti-G beta sera led us to suggest that 17 beta-oestradiol induces qualitative modifications in Go,i proteins leading to a stabilization of the associated form of the heterotrimer G alpha o,i beta gamma.	Estradiol	180-190	guanine nucleotide binding protein, alpha O	Mus musculus	118-127
1963397-5	1990	Results of ADP-ribosylation experiments with cholera toxin or pertussis toxin and of immunoblot experiments with anti-G alpha o and anti-G beta sera led us to suggest that 17 beta-oestradiol induces qualitative modifications in Go,i proteins leading to a stabilization of the associated form of the heterotrimer G alpha o,i beta gamma.	Estradiol	180-190	guanine nucleotide binding protein, alpha O	Mus musculus	312-321
1963397-6	1990	In fact, pretreatment with pertussis toxin (which impairs G alpha o,i beta gamma dissociation) mimics the effects of 17 beta-oestradiol on responses of adenylate cyclase to stimulatory and inhibitory agonists.	Estradiol	117-135	guanine nucleotide binding protein, alpha O	Mus musculus	58-67
3131483-6	1988	On removal of VTN, the level of Go alpha decreased to control levels within 24 h. The levels of the alpha subunit of Gi and the common beta subunit were not affected by VTN treatment.	Veratridine	14-17	guanine nucleotide binding protein, alpha O	Mus musculus	32-40
34248508-1	2021	Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce signals from G protein-coupled receptors (GPCRs) to effector ion channels and enzymes Galphao, a member of the pertussis toxin-sensitive G i/o family, is widely expressed in the brain, although its role within a neuronal context remains largely unknown.	Guanine Nucleotides	15-33	guanine nucleotide binding protein, alpha O	Mus musculus	160-167
2504885-5	1989	Treatment of PC12 cells and neuroblastoma x glioma hybrid NG108-15 cells with nerve growth factor and forskolin, respectively, caused the extension of neuronal-like processes and increase in the level of Go alpha by 60-80%, but small changes in the levels of Gi2 alpha.	Colforsin	102-111	guanine nucleotide binding protein, alpha O	Mus musculus	204-212
2494307-1	1989	The presence of GTP-binding proteins (G proteins) has been studied in murine adult choroid plexuses and cultured fetal choroidal or hypothalamic ependymal cells by ADP-ribosylation catalyzed by Bordetella pertussis toxin (PTX) and by immunodetection using affinity-purified polyclonal antibodies against the alpha subunit of the Go protein (Go alpha), the major brain G protein.	Guanosine Triphosphate	16-19	guanine nucleotide binding protein, alpha O	Mus musculus	341-349
2494307-2	1989	ADP-ribosylation with 32P-NAD and PTX of choroid plexus revealed an intense labeling at the 40 kDa level in addition to the known PTX-substrates at 41 kDa (Gi alpha) and 39 kDa (Go alpha).	32p-nad	22-29	guanine nucleotide binding protein, alpha O	Mus musculus	178-186
3128978-2	1988	Similar experiments with poorly hydrolyzed analogues of GTP caused release of a significant fraction (some 50% within 60 minutes) of Go alpha into the supernatant.	Guanosine Triphosphate	56-59	guanine nucleotide binding protein, alpha O	Mus musculus	133-141
32329702-3	2020	The aim of the present study was to investigate the antioxidant, anticancer activitie of zidovudine and its alpha-O-glycosylated derivative obtained by biosynthesis using the filamentous fungi Cunninghamela echinulata.	Zidovudine	89-99	guanine nucleotide binding protein, alpha O	Mus musculus	108-115
33857254-0	2021	Neuromedin U uses Galphai2 and Galphao to suppress glucose-stimulated Ca2+ signaling and insulin secretion in pancreatic beta cells.	Glucose	51-58	guanine nucleotide binding protein, alpha O	Mus musculus	31-38
33857254-6	2021	Pretreatment with the Galphai/o inhibitor Bordetella pertussis toxin (PTX), but not the Galphaq inhibitor YM254890, abolished NMU-induced suppression of glucose-stimulated insulin secretion and calcium response in beta cells.	Glucose	153-160	guanine nucleotide binding protein, alpha O	Mus musculus	22-29
33857254-6	2021	Pretreatment with the Galphai/o inhibitor Bordetella pertussis toxin (PTX), but not the Galphaq inhibitor YM254890, abolished NMU-induced suppression of glucose-stimulated insulin secretion and calcium response in beta cells.	Calcium	194-201	guanine nucleotide binding protein, alpha O	Mus musculus	22-29
31907305-0	2020	Mice with GNAO1 R209H Movement Disorder Variant Display Hyperlocomotion Alleviated by Risperidone.	Risperidone	86-97	guanine nucleotide binding protein, alpha O	Mus musculus	10-15
31907305-15	2020	Here we show, using a novel Gnao1 +/R209H mouse, that there is a clear behavioral phenotype that is suppressed by risperidone.	Risperidone	114-125	guanine nucleotide binding protein, alpha O	Mus musculus	28-33
33857254-7	2021	Knockdown of Galphai2 and Galphao in beta cells counteracted NMU-induced suppression of insulin secretion and gene alterations related to mitochondrial fusion (Mfn1, Mfn2), fission (Fis1, Drp1), mitophagy (Pink1, Park2), mitochondrial dynamics (Pgc-1alpha, Nrf1, and Tfam), ER stress (Chop, Atp2a3, Ryr2, and Itpr2), intracellular ATP level, and mitochondrial membrane potential.	Adenosine Triphosphate	331-334	guanine nucleotide binding protein, alpha O	Mus musculus	26-33
33857254-9	2021	We concluded that NMUR1 coupled to PTX-sensitive Galphai2 and Galphao proteins in beta cells reduced intracellular Ca2+ influx and cAMP level, thereby causing beta-cell dysfunction and impairment.	Cyclic AMP	131-135	guanine nucleotide binding protein, alpha O	Mus musculus	62-69
32329702-4	2020	METHODS: Was performed an evaluation of the cytotoxic potential zidovudine and its alpha-O-glycosylated in fibroblasts and melanoma cells by the tetrazolium reduction method (MTT), and the antioxidant activity of this derivative.	monooxyethylene trimethylolpropane tristearate	175-178	guanine nucleotide binding protein, alpha O	Mus musculus	83-90
28971229-0	2018	Role of the guanine nucleotide binding protein, Galphao, in the development of morphine tolerance and dependence.	Morphine	79-87	guanine nucleotide binding protein, alpha O	Mus musculus	48-55
30682176-13	2019	Male Gnao1+/G203R mice also showed enhanced seizure propensity in the pentylenetetrazole kindling test.	Pentylenetetrazole	70-88	guanine nucleotide binding protein, alpha O	Mus musculus	5-10
29437250-6	2018	Both shRNA-mediated knockdown of Galphao and intracellular application of QEHA peptide abolished the inhibitory effects of melatonin.	Melatonin	123-132	guanine nucleotide binding protein, alpha O	Mus musculus	33-40
28971229-3	2018	Evidence suggests that the antinociceptive effects of morphine are mediated by Galphao.	Morphine	54-62	guanine nucleotide binding protein, alpha O	Mus musculus	79-86
28971229-4	2018	However, the role of Galphao in the development of morphine tolerance and dependence is unknown.	Morphine	51-59	guanine nucleotide binding protein, alpha O	Mus musculus	21-28
27867358-5	2016	Results show that, in mouse brain cortex, cannabinoid agonists are able to significantly stimulate not only the classical inhibitory Galphai/o subunits but also other G subunits like Galphaz, Galphaq/11, and Galpha12/13.	Cannabinoids	42-53	guanine nucleotide binding protein, alpha O	Mus musculus	133-140
28971229-5	2018	OBJECTIVE: The objective of the study is to evaluate the contribution of Galphao to the development of morphine tolerance and dependence in mice.	Morphine	103-111	guanine nucleotide binding protein, alpha O	Mus musculus	73-80
28971229-11	2018	With chronic morphine treatment, Galphao +/- mice developed tolerance faster and displayed more severe naltrexone-precipitated withdrawal in some behaviors than did wild-type littermates.	Morphine	13-21	guanine nucleotide binding protein, alpha O	Mus musculus	33-40
28971229-11	2018	With chronic morphine treatment, Galphao +/- mice developed tolerance faster and displayed more severe naltrexone-precipitated withdrawal in some behaviors than did wild-type littermates.	Naltrexone	103-113	guanine nucleotide binding protein, alpha O	Mus musculus	33-40
28971229-13	2018	CONCLUSIONS: These data suggest that the guanine nucleotide binding protein Galphao offers some protection against the development of morphine tolerance and dependence.	Guanine Nucleotides	41-59	guanine nucleotide binding protein, alpha O	Mus musculus	76-83
28971229-13	2018	CONCLUSIONS: These data suggest that the guanine nucleotide binding protein Galphao offers some protection against the development of morphine tolerance and dependence.	Morphine	134-142	guanine nucleotide binding protein, alpha O	Mus musculus	76-83
21654736-6	2011	Reduction in Galpha(o) levels attenuated the supraspinal antinociception produced by morphine, methadone, and nalbuphine, with the magnitude of suppression dependent on agonist efficacy.	Morphine	85-93	guanine nucleotide binding protein, alpha O	Mus musculus	13-22
27065801-5	2016	Interestingly, this pathway is mediated by Gnao activation, leading to Cl(-) efflux; however, the activation of adenylyl cyclase III (ACIII), the recruitment of Ca(2+) from extra-or intracellular stores, and phosphatidylinositol 3-kinase-dependent signaling (PI signaling) are not involved.	Phosphatidylinositols	208-228	guanine nucleotide binding protein, alpha O	Mus musculus	43-47
23224819-0	2013	Palmitoylcarnitine affects localization of growth associated protein GAP-43 in plasma membrane subdomains and its interaction with Galpha(o) in neuroblastoma NB-2a cells.	Palmitoylcarnitine	0-18	guanine nucleotide binding protein, alpha O	Mus musculus	131-140
23077035-7	2012	Notably, numerous genes for G-protein-coupled receptors (GPCRs) and G-protein effectors involved in calcium signaling were significantly regulated, mostly down (for example, Cxcr4, Adra2a, Ednra, P2ry1, Gnao1, Gng7), but some up (for example, P2ry14, P2ry6, Ccrl2, Gnb4).	Calcium	100-107	guanine nucleotide binding protein, alpha O	Mus musculus	203-208
23467353-5	2013	Mice expressing Galphao RGSi subunits exhibited a naltrexone-sensitive enhancement of baseline latency in both the hot-plate and warm-water tail-withdrawal tests.	Naltrexone	50-60	guanine nucleotide binding protein, alpha O	Mus musculus	16-23
23467353-5	2013	Mice expressing Galphao RGSi subunits exhibited a naltrexone-sensitive enhancement of baseline latency in both the hot-plate and warm-water tail-withdrawal tests.	Water	134-139	guanine nucleotide binding protein, alpha O	Mus musculus	16-23
23224819-7	2013	GAP-43 co-precipitated with a monomeric form of Galpha(o), a phenomenon diminished after palmitoylcarnitine treatment and paralleled by a decrease of Galpha(o) in the raft fraction.	Palmitoylcarnitine	89-107	guanine nucleotide binding protein, alpha O	Mus musculus	48-57
21654736-6	2011	Reduction in Galpha(o) levels attenuated the supraspinal antinociception produced by morphine, methadone, and nalbuphine, with the magnitude of suppression dependent on agonist efficacy.	Methadone	95-104	guanine nucleotide binding protein, alpha O	Mus musculus	13-22
21654736-6	2011	Reduction in Galpha(o) levels attenuated the supraspinal antinociception produced by morphine, methadone, and nalbuphine, with the magnitude of suppression dependent on agonist efficacy.	Nalbuphine	110-120	guanine nucleotide binding protein, alpha O	Mus musculus	13-22
21654736-9	2011	However, the action of the partial agonist nalbuphine was compromised, showing that reduction in Galpha(o) protein does decrease spinal antinociception, but suggesting a higher Galpha(o) protein reserve.	Nalbuphine	43-53	guanine nucleotide binding protein, alpha O	Mus musculus	97-106
20622165-7	2010	Electron microscope and total internal reflection fluorescence-based assays were used to evaluate how Galphao regulates insulin vesicle docking and secretion in response to glucose stimulation.	Glucose	173-180	guanine nucleotide binding protein, alpha O	Mus musculus	102-109
21317923-8	2011	Based on structural analyses, we propose that the enhanced rate of nucleotide exchange in Galphao R243H results from loss of the highly conserved electrostatic interaction of R243 with E43, located in the in the P-loop that represents the binding site for the alpha- and beta-phosphates of the nucleotide.	Phosphates	276-286	guanine nucleotide binding protein, alpha O	Mus musculus	90-97
18584336-5	2009	We found enrichment of alpha (Galphao, Galphaq) and beta subunits (beta4/beta2 and beta5) of guanine nucleotide-binding proteins and of two calcium-binding proteins, calretinin and hippocalcin-like protein-1.	Guanine Nucleotides	93-111	guanine nucleotide binding protein, alpha O	Mus musculus	23-72
19460419-6	2009	The most salient candidate gene within this QTL, Gnao1 (guanine nucleotide binding protein, alpha(o); G alpha(o); 96.3 Mb), was tested for functional relevance using quantitative PCR and an antisense oligodeoxynucleotide strategy.	Oligodeoxyribonucleotides	200-220	guanine nucleotide binding protein, alpha O	Mus musculus	49-54
19460419-7	2009	The expression of Gnao1 in the locus coeruleus was found to be upregulated in morphine-dependent B6 but not A/J mice.	Morphine	78-86	guanine nucleotide binding protein, alpha O	Mus musculus	18-23
19460419-8	2009	Antisense knockdown of Gnao1 reduced NPW jumping in B6, but not A/J, mice rendered dependent on either morphine or heroin, largely rescuing the original strain difference.	Morphine	103-111	guanine nucleotide binding protein, alpha O	Mus musculus	23-28
15585744-7	2005	Using pull-down assays with glutathione S-transferase-fused GRIN1 deletion mutants, Galphao binding regions were localized to amino acid residues 716 to 746 and 797 to 827 of GRIN1.	Glutathione	28-39	guanine nucleotide binding protein, alpha O	Mus musculus	84-91
16325780-7	2006	Both G protein coupling and D3R signaling, measured as inhibition of cAMP production, were greatly enhanced by co-expression of exogenous alpha subunit of Go (Goalpha) or adenylyl cyclase type 5 (AC5), respectively.	Cyclic AMP	69-73	guanine nucleotide binding protein, alpha O	Mus musculus	138-167
15657046-5	2005	G(alpha)o/i-induced activation of endogenous Rap1 in Neuro-2A cells is blocked by the proteasomal inhibitor lactacystin.	lactacystin	108-119	guanine nucleotide binding protein, alpha O	Mus musculus	0-9
15657046-8	2005	The endogenous G(alpha)o/i-coupled cannabinoid (CB1) receptor in Neuro-2A cells stimulates the degradation of Rap1GAPII; activation of Rap1 and treatment with pertussis toxin or lactacystin blocks these effects.	lactacystin	178-189	guanine nucleotide binding protein, alpha O	Mus musculus	15-24