PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33662400-0	2021	SSSPTA is essential for serine palmitoyltransferase function during development and hematopoiesis.	Serine	24-30	serine palmitoyltransferase small subunit A	Homo sapiens	0-6
33662400-2	2021	The larger subunits SPTLC1 and SPTLC2/SPTLC3 together form the catalytic core while a smaller third subunit either SSSPTA or SSSPTB has been shown to increase the catalytic efficiency and provide substrate specificity for the fatty acyl-CoA substrates.	Acyl Coenzyme A	226-240	serine palmitoyltransferase small subunit A	Homo sapiens	115-121
32029474-6	2020	AHR bound and activated the gene promoter of serine palmitoyltransferase small subunit A (SPTSSA), which encodes a subunit of the serine palmitoyl transferase that catalyzes the first and rate-limiting step in de novo sphingolipid biosynthesis.	2,3-bis-(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinylserine	45-61	serine palmitoyltransferase small subunit A	Homo sapiens	90-96
33558761-2	2021	In humans, the first and rate-limiting step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase holocomplex, which consists of catalytic components (SPTLC1 and SPTLC2) and regulatory components (ssSPTa and ORMDL3).	Sphingolipids	47-59	serine palmitoyltransferase small subunit A	Homo sapiens	217-223
33558761-2	2021	In humans, the first and rate-limiting step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase holocomplex, which consists of catalytic components (SPTLC1 and SPTLC2) and regulatory components (ssSPTa and ORMDL3).	Serine	90-96	serine palmitoyltransferase small subunit A	Homo sapiens	217-223
33558762-5	2021	SPTssa participates in acyl-CoA coordination, thereby stimulating the SPT activity and regulating the substrate selectivity.	Acyl Coenzyme A	23-31	serine palmitoyltransferase small subunit A	Homo sapiens	0-6
32029474-6	2020	AHR bound and activated the gene promoter of serine palmitoyltransferase small subunit A (SPTSSA), which encodes a subunit of the serine palmitoyl transferase that catalyzes the first and rate-limiting step in de novo sphingolipid biosynthesis.	Sphingolipids	218-230	serine palmitoyltransferase small subunit A	Homo sapiens	45-88
32029474-6	2020	AHR bound and activated the gene promoter of serine palmitoyltransferase small subunit A (SPTSSA), which encodes a subunit of the serine palmitoyl transferase that catalyzes the first and rate-limiting step in de novo sphingolipid biosynthesis.	Sphingolipids	218-230	serine palmitoyltransferase small subunit A	Homo sapiens	90-96
23426370-4	2013	In combination with analysis of isoform chimera and site-directed mutagenesis, a single amino acid residue in this core (Met(25) in ssSPTa and Val(25) in ssSPTb) was identified which confers specificity for palmitoyl- or stearoyl-CoA, respectively, in both yeast and mammalian cells.	palmitoyl- or	207-220	serine palmitoyltransferase small subunit A	Homo sapiens	132-138
23426370-4	2013	In combination with analysis of isoform chimera and site-directed mutagenesis, a single amino acid residue in this core (Met(25) in ssSPTa and Val(25) in ssSPTb) was identified which confers specificity for palmitoyl- or stearoyl-CoA, respectively, in both yeast and mammalian cells.	stearoyl-coenzyme A	221-233	serine palmitoyltransferase small subunit A	Homo sapiens	132-138
23510452-9	2013	These results suggest that ssSPTa plays a role in fatty acid remodeling of PI, probably by facilitating the MAM localization of LPIAT1.	Fatty Acids	50-60	serine palmitoyltransferase small subunit A	Homo sapiens	27-33