PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
29753745-0	2018	1-alpha,25-dihydroxyvitamin D3 potentiates avian osteoclast activation by increasing the formation of zipper-like structure via Src/Rac1 signaling.	Calcitriol	0-30	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	128-131
31363885-6	2019	Accordingly, the BMPR inhibitor dorsomorphin prevents c-Src activation and specific inhibition of c-Src significantly reduces downstream VEGFR2 phosphorylation and the angiogenic activity exerted by BMP4 in a chick embryo chorioallantoic membrane assay.	bmpr	17-21	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	54-59
31363885-6	2019	Accordingly, the BMPR inhibitor dorsomorphin prevents c-Src activation and specific inhibition of c-Src significantly reduces downstream VEGFR2 phosphorylation and the angiogenic activity exerted by BMP4 in a chick embryo chorioallantoic membrane assay.	dorsomorphin	32-44	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	54-59
31363885-6	2019	Accordingly, the BMPR inhibitor dorsomorphin prevents c-Src activation and specific inhibition of c-Src significantly reduces downstream VEGFR2 phosphorylation and the angiogenic activity exerted by BMP4 in a chick embryo chorioallantoic membrane assay.	dorsomorphin	32-44	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	98-103
29753745-6	2018	Moreover, 1alpha,25-(OH)2D3 regulates the OC cytoskeleton by increasing the formation of zipper-like structure in OC precursor cells to potentiate OC activity via the Src/Rac1 signaling pathway.	1alpha	10-16	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	167-170
29753745-6	2018	Moreover, 1alpha,25-(OH)2D3 regulates the OC cytoskeleton by increasing the formation of zipper-like structure in OC precursor cells to potentiate OC activity via the Src/Rac1 signaling pathway.	25-(oh)2d3	17-27	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	167-170
19888460-1	2009	The Src family kinases possess two sites of tyrosine phosphorylation that are critical to the regulation of kinase activity.	Tyrosine	44-52	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	4-7
27795443-2	2017	Previously, we reported that blocking AP-1 using the c-Jun dominant negative mutant TAM67 induced senescence, adipogenesis, or apoptosis in v-Src-transformed chicken embryo fibroblasts (CEFs) whereas inhibition of JunD by short hairpin RNA (shRNA) specifically induced apoptosis.	tam67	84-89	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	142-145
24781942-7	2014	CONCLUSIONS: Muller cells express the alpha2A-adrenergic receptor, and brimonidine triggers both Src-kinase- and matrix metalloproteinase-mediated autocrine ligand-dependent activation of epidermal growth factor receptors on Muller cells.	Brimonidine Tartrate	71-82	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	97-100
21507983-4	2011	In contrast, three distinct phenotypes were observed when TAM67 was expressed in v-Src-transformed CEF.	tam67	58-63	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	83-86
28436416-5	2017	Finally, we show that Src-mediated LPP phosphorylation at specific tyrosine residues (Y245/301/302) is critical for invadopodia formation, breast cancer cell invasion and metastasis.	Tyrosine	67-75	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	22-25
23770989-11	2013	Moreover, DMU-212 concentration-dependently suppressed VEGF-induced phosphorylation of VEGFR2, and inhibited phosphorylation of multiple downstream signaling components in the VEGFR2 pathway, including c-Src, FAK, Erk1/2, Akt, mTOR, and p70S6K in HUVECs.	dmu-212	10-17	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	202-207
21214560-4	2011	More specifically, the cannabinoid 1 receptor (CB1R) agonist methanandamide induced tyrosine phosphorylation and transactivation of fibroblast growth factor receptor (FGFR)1 via Src and Fyn, which drove an amplification wave in ERK1/2 activation.	methanandamide	61-75	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	178-181
19888460-2	2009	Autophosphorylation on an activation loop tyrosine residue (Tyr 416 in commonly used chicken c-Src numbering) increases catalytic activity, while phosphorylation of a C-terminal tyrosine (Tyr 527 in c-Src) inhibits activity.	Tyrosine	42-50	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	93-98
19888460-2	2009	Autophosphorylation on an activation loop tyrosine residue (Tyr 416 in commonly used chicken c-Src numbering) increases catalytic activity, while phosphorylation of a C-terminal tyrosine (Tyr 527 in c-Src) inhibits activity.	Tyrosine	60-63	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	93-98
19888460-2	2009	Autophosphorylation on an activation loop tyrosine residue (Tyr 416 in commonly used chicken c-Src numbering) increases catalytic activity, while phosphorylation of a C-terminal tyrosine (Tyr 527 in c-Src) inhibits activity.	Tyrosine	188-191	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	199-204
19888460-3	2009	The latter modification is achieved by the tyrosine kinase Csk (C-terminal Src Kinase), but the complete inactivation of the Src family kinases also requires the dephosphorylation of the activation loop tyrosine.	Tyrosine	43-51	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	75-78
19306958-6	2009	Furthermore, phosphorylation levels of Src and focal adhesion kinase (FAK) were decreased by rottlerin treatment.	rottlerin	93-102	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	39-42
19306958-7	2009	Cell treatment with PP2, an inhibitor of Src family kinase, or electroporation of FAK specific siRNA, suppressed cell migration in a wound-healing assay.	pp2	20-23	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	41-44
16996007-1	2006	BACKGROUND: Sam68 plays an important role as a multiple functional RNA binding nuclear protein in cell cycle progress, RNA usage, signal transduction, and tyrosine phosphorylation by Src during mitosis.	Tyrosine	155-163	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	183-186
19168198-2	2009	We have previously demonstrated that ARV S1133 activates proapoptotic signaling from Src to p53, and further investigated how ARV S1133 modulates p53.	omega-N-Allylarginine	37-40	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	85-88
16567399-5	2006	On the other hand, a mutant chicken Src, in which the His-122 residue is replaced by Arg, showed decreased recognition by mAb327.	Histidine	54-57	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	36-39
16567399-5	2006	On the other hand, a mutant chicken Src, in which the His-122 residue is replaced by Arg, showed decreased recognition by mAb327.	Arginine	85-88	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	36-39
12952943-5	2003	The activation of c-Raf by bFGF/alphavbeta3 not only depended on FAK, but also required p21-activated kinase-dependent phosphorylation of serine 338 on c-Raf, whereas VEGF-mediated c-Raf phosphorylation/activation depended on Src, but not Pak.	Serine	138-144	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	226-229
16306994-8	2005	At the endpoint of mRNA transport, the protein kinase Src promotes translation by phosphorylating a key tyrosine residue in ZBP1 that is required for binding to RNA.	Tyrosine	104-112	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	54-57
14699156-2	2004	In this study, we observed that trichostatin A (TSA), a specific histone deacetylase inhibitor, could effectively inhibit the growth of v-Src-transformed (IV5) cells and abrogate their ability to form colonies in soft agar.	trichostatin A	32-46	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	138-141
14699156-2	2004	In this study, we observed that trichostatin A (TSA), a specific histone deacetylase inhibitor, could effectively inhibit the growth of v-Src-transformed (IV5) cells and abrogate their ability to form colonies in soft agar.	trichostatin A	48-51	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	138-141
14699156-6	2004	When active Src-expressing chicken embryonic cells were forced to overexpress p97(Eps8), they became resistant to TSA-mediated anti-proliferation.	trichostatin A	114-117	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	12-15
12163178-1	2002	Sam68 is an RNA binding protein that is tyrosine-phosphorylated by Src during mitosis and has been postulated to have a role in cell cycle control by modulating RNA metabolism.	Tyrosine	40-48	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	67-70
12757738-6	2003	However, PP2, a selective inhibitor of the src family of protein tyrosine kinases, and piceatannol, an inhibitor of Syk tyrosine kinases, both significantly attenuated the CR-mediated degranulation.	pp2	9-12	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	43-46
12468645-3	2002	As chicken c-Src is known to be activated upon dephosphorylation of tyrosine 527 (Y527, corresponding to Y530 in human), we here employed a monoclonal antibody, clone 28, directed against the active form of human c-Src whose Y530 is dephosphorylated, and investigated whether c-Src became dephosphorylated at Y530 and thereby activated during decidualization.	Tyrosine	68-76	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	11-16
12359153-6	2002	CALI of pp60(c-src) resulted in an 85% inactivation of its kinase activity and a 63% reduction in phosphotyrosine immunofluorescence in neurons.	Phosphotyrosine	98-113	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	13-18
10967554-0	2000	Activation of Src kinase in skeletal muscle cells by 1, 1,25-(OH(2))-vitamin D(3) correlates with tyrosine phosphorylation of the vitamin D receptor (VDR) and VDR-Src interaction.	Vitamin D	69-78	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	14-17
11741312-3	2001	Coimmunoprecipitation experiments revealed that 1,25(OH)(2)D(3) induces the formation of complexes between c-Src and c-myc, in agreement with the above results and previous studies showing hormone-dependent association between c-Src and tyrosine phosphorylated VDR and c-Src mediated c-myc tyrosine phosphorylation.	Tyrosine	237-245	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	107-112
11741312-3	2001	Coimmunoprecipitation experiments revealed that 1,25(OH)(2)D(3) induces the formation of complexes between c-Src and c-myc, in agreement with the above results and previous studies showing hormone-dependent association between c-Src and tyrosine phosphorylated VDR and c-Src mediated c-myc tyrosine phosphorylation.	Tyrosine	237-245	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	227-232
11741312-3	2001	Coimmunoprecipitation experiments revealed that 1,25(OH)(2)D(3) induces the formation of complexes between c-Src and c-myc, in agreement with the above results and previous studies showing hormone-dependent association between c-Src and tyrosine phosphorylated VDR and c-Src mediated c-myc tyrosine phosphorylation.	Tyrosine	237-245	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	227-232
11741312-3	2001	Coimmunoprecipitation experiments revealed that 1,25(OH)(2)D(3) induces the formation of complexes between c-Src and c-myc, in agreement with the above results and previous studies showing hormone-dependent association between c-Src and tyrosine phosphorylated VDR and c-Src mediated c-myc tyrosine phosphorylation.	Tyrosine	290-298	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	107-112
11741312-3	2001	Coimmunoprecipitation experiments revealed that 1,25(OH)(2)D(3) induces the formation of complexes between c-Src and c-myc, in agreement with the above results and previous studies showing hormone-dependent association between c-Src and tyrosine phosphorylated VDR and c-Src mediated c-myc tyrosine phosphorylation.	Tyrosine	290-298	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	227-232
11741312-3	2001	Coimmunoprecipitation experiments revealed that 1,25(OH)(2)D(3) induces the formation of complexes between c-Src and c-myc, in agreement with the above results and previous studies showing hormone-dependent association between c-Src and tyrosine phosphorylated VDR and c-Src mediated c-myc tyrosine phosphorylation.	Tyrosine	290-298	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	227-232
11524430-0	2001	Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines.	Tyrosine	85-93	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	0-3
11524430-0	2001	Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines.	Phosphotyrosine	130-145	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	0-3
11524430-2	2001	Tyrosine phosphorylation of DAPP-1 appears important for appropriate intracellular targeting and creates a potential binding site for Src homology 2 domain-containing proteins.	Tyrosine	0-8	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	134-137
11524430-4	2001	Transient overexpression of Src most effectively, compared with Bmx and Syk, augments basal and PDGF-stimulated tyrosine phosphorylation of DAPP-1, whereas overexpression of dominant-negative Src, but not dominant-negative Bmx, inhibits PDGF-stimulated phosphorylation of DAPP-1.	Tyrosine	112-120	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	28-31
11524430-9	2001	We conclude that Src family kinases are responsible for tyrosine phosphorylation of DAPP-1 in vivo and that PI3K regulation is at the level of PH domain-mediated translocation of DAPP-1 to PI3K products in the membrane.	Tyrosine	56-64	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	17-20
11320329-0	2001	Post-translational modification of the N-terminal His tag interferes with the crystallization of the wild-type and mutant SH3 domains from chicken src tyrosine kinase.	Histidine	50-53	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	147-150
10964910-7	2000	The sterol-induced increase in tyrosine phosphorylation of c-myc, a finding not reported before for cell growth regulators, was totally suppressed by the specific Src inhibitor PP1.	Sterols	4-10	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	163-166
10964910-7	2000	The sterol-induced increase in tyrosine phosphorylation of c-myc, a finding not reported before for cell growth regulators, was totally suppressed by the specific Src inhibitor PP1.	Tyrosine	31-39	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	163-166
11035913-2	2000	A similar, but less marked, increase in c-Src PTK activity occurs upon incubation of CEFs in calcium-free phosphate-buffered saline, which also causes a decrease in cell-substrate adhesion.	cefs	85-89	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	40-45
11035913-2	2000	A similar, but less marked, increase in c-Src PTK activity occurs upon incubation of CEFs in calcium-free phosphate-buffered saline, which also causes a decrease in cell-substrate adhesion.	Calcium	93-100	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	40-45
11035913-2	2000	A similar, but less marked, increase in c-Src PTK activity occurs upon incubation of CEFs in calcium-free phosphate-buffered saline, which also causes a decrease in cell-substrate adhesion.	Phosphate-Buffered Saline	106-131	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	40-45
11035913-4	2000	The phosphotyrosine phosphatase inhibitor phenylarsine oxide blocks the increase in c-Src PTK activity seen following treatment with trypsin and the morphological changes associated with the disruption of cell-substrate adhesion.	oxophenylarsine	42-60	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	84-89
11035913-6	2000	Treatment of cells with cytochalasin D, which disrupts actin filaments but not cell-substrate adhesion, causes only a slight increase in c-Src PTK activity.	Cytochalasin D	24-38	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	137-142
11029551-8	2000	VIP stimulates both overall phosphorylation at unknown sites and phosphotyrosine dephosphorylation in pp60(c-src).	Phosphotyrosine	65-80	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	107-112
10967554-0	2000	Activation of Src kinase in skeletal muscle cells by 1, 1,25-(OH(2))-vitamin D(3) correlates with tyrosine phosphorylation of the vitamin D receptor (VDR) and VDR-Src interaction.	Tyrosine	98-106	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	14-17
10967554-1	2000	The rapid effect of 1 alpha,25(OH(2))-vitamin D(3) [1 alpha, 25(OH(2))D(3)] on tyrosine kinase Src and its relationship to the vitamin D receptor (VDR) was investigated to further characterize the hormone signaling mechanism in chick muscle cells.	Water	31-37	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	95-98
10967554-1	2000	The rapid effect of 1 alpha,25(OH(2))-vitamin D(3) [1 alpha, 25(OH(2))D(3)] on tyrosine kinase Src and its relationship to the vitamin D receptor (VDR) was investigated to further characterize the hormone signaling mechanism in chick muscle cells.	Vitamin D	38-47	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	95-98
10967554-3	2000	Immunoblotting with anti-phosphotyrosine antibody of immunoprecipitated Src showed that the hormone decreased Src tyrosine phosphorylation state with maximal effects at 5 min.	Phosphotyrosine	25-40	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	72-75
10967554-3	2000	Immunoblotting with anti-phosphotyrosine antibody of immunoprecipitated Src showed that the hormone decreased Src tyrosine phosphorylation state with maximal effects at 5 min.	Phosphotyrosine	25-40	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	110-113
10967554-3	2000	Immunoblotting with anti-phosphotyrosine antibody of immunoprecipitated Src showed that the hormone decreased Src tyrosine phosphorylation state with maximal effects at 5 min.	Tyrosine	32-40	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	72-75
10967554-3	2000	Immunoblotting with anti-phosphotyrosine antibody of immunoprecipitated Src showed that the hormone decreased Src tyrosine phosphorylation state with maximal effects at 5 min.	Tyrosine	32-40	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	110-113
10967554-7	2000	In agreement with Src being a SH2-domain containing protein involved in recognition of tyrosine-phosphorylated targets, immunoprecipitation with anti-Src antibody under native conditions followed by blotting with anti-VDR antibody, or using the antibodies in inverse order, showed that the VDR co-precipitates with Src, thus indicating the existence of a VDR/Src complex.	Tyrosine	87-95	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	18-21
10967554-9	2000	These results altogether provide the first evidence to date for 1 alpha,25(OH(2))D(3) activation involving Src association to tyrosine phosphorylated VDR.	Tyrosine	126-134	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	107-110
10644991-5	2000	These constructs were used to assess the effects of the Yes SH3 and SH2 domains on the ability of Src to form stable complexes with and induce tyrosine phosphorylation of Src SH3 and SH2 domain binding partners in vivo.	Tyrosine	143-151	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	98-101
10967554-0	2000	Activation of Src kinase in skeletal muscle cells by 1, 1,25-(OH(2))-vitamin D(3) correlates with tyrosine phosphorylation of the vitamin D receptor (VDR) and VDR-Src interaction.	1, 1,25-(oh(2))	53-68	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	14-17
10644991-5	2000	These constructs were used to assess the effects of the Yes SH3 and SH2 domains on the ability of Src to form stable complexes with and induce tyrosine phosphorylation of Src SH3 and SH2 domain binding partners in vivo.	Tyrosine	143-151	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	171-174
9350057-7	1997	Co-expression of activated Src (pp60(527F)) with AFAP-110 in Cos-1 cells permit tyrosine phosphorylation of AFAP-110 and stable complex formation with pp60(527F).	carbonyl sulfide	61-64	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	27-30
10339427-3	1999	These proteins are representative of a large family of tyrosine kinases, the activity of which is tightly controlled by inhibitory phosphorylation of a carboxyterminal tyrosine residue (Tyr527 in chicken c-Src); this phosphorylation induces the kinases to form an inactive conformation.	Tyrosine	55-63	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	204-209
10036244-3	1999	We found that activation of v-Src induced association of tyrosine phosphorylated p190 with p120(RasGAP) and stimulation of p120(RasGAP)-associated RhoGAP activity, although p120(RasGAP) itself was not a target for phosphorylation by v-Src in chicken embryo cells.	Tyrosine	57-65	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	30-33
9371727-3	1997	Here we show that v-Src-induced neurite outgrowth is suppressed by the selective PtdIns 3-kinase inhibitor LY294002, suggesting that this effect of v-Src in PC12 cells also requires the activity of the lipid kinase.	Phosphatidylinositols	81-87	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	20-23
9371727-3	1997	Here we show that v-Src-induced neurite outgrowth is suppressed by the selective PtdIns 3-kinase inhibitor LY294002, suggesting that this effect of v-Src in PC12 cells also requires the activity of the lipid kinase.	Phosphatidylinositols	81-87	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	150-153
9371727-3	1997	Here we show that v-Src-induced neurite outgrowth is suppressed by the selective PtdIns 3-kinase inhibitor LY294002, suggesting that this effect of v-Src in PC12 cells also requires the activity of the lipid kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	20-23
9371727-3	1997	Here we show that v-Src-induced neurite outgrowth is suppressed by the selective PtdIns 3-kinase inhibitor LY294002, suggesting that this effect of v-Src in PC12 cells also requires the activity of the lipid kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	150-153
9988270-3	1999	Studies of the mechanism of c-Src regulation have suggested that c-Src kinase activity is downregulated by phosphorylation of a critical carboxy-terminal tyrosine (Tyr 530 in human c-Src, equivalent to Tyr 527 in chicken Src) and have implied the existence of activating mutations in this C-terminal regulatory region.	Tyrosine	154-162	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	30-33
9988270-3	1999	Studies of the mechanism of c-Src regulation have suggested that c-Src kinase activity is downregulated by phosphorylation of a critical carboxy-terminal tyrosine (Tyr 530 in human c-Src, equivalent to Tyr 527 in chicken Src) and have implied the existence of activating mutations in this C-terminal regulatory region.	Tyrosine	164-167	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	30-33
9988270-3	1999	Studies of the mechanism of c-Src regulation have suggested that c-Src kinase activity is downregulated by phosphorylation of a critical carboxy-terminal tyrosine (Tyr 530 in human c-Src, equivalent to Tyr 527 in chicken Src) and have implied the existence of activating mutations in this C-terminal regulatory region.	Tyrosine	202-205	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	30-33
9350057-7	1997	Co-expression of activated Src (pp60(527F)) with AFAP-110 in Cos-1 cells permit tyrosine phosphorylation of AFAP-110 and stable complex formation with pp60(527F).	Tyrosine	80-88	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	27-30
9380798-5	1997	However, treatment with diclofenac following pp60v-src activation produced a much stronger response beginning within 6 hours of treatment that resulted in 100% lethality.	Diclofenac	24-34	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	51-54
9108021-1	1997	The activity of the c-Src protein tyrosine kinase is regulated by phosphorylation of a tyrosine residue (Tyr-527) in the C-terminal tail of the molecule.	Tyrosine	34-42	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	20-25
9108021-1	1997	The activity of the c-Src protein tyrosine kinase is regulated by phosphorylation of a tyrosine residue (Tyr-527) in the C-terminal tail of the molecule.	Tyrosine	105-108	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	20-25
9108021-2	1997	Phosphorylation of Tyr-527 promotes association of the tail with the SH2 domain and a concomitant reduction of the enzymatic activity of Src.	Tyrosine	19-22	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	137-140
9108021-5	1997	The cells were engineered to express Src along with Csk, a protein kinase able to phosphorylate Tyr-527 efficiently.	Tyrosine	96-99	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	37-40
9108021-6	1997	Mass spectrometric analysis showed that purified Src was homogeneously phosphorylated at Tyr-527.	Tyrosine	89-92	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	49-52
8856081-8	1996	Kinetic measurements for two exogenous substrates, the Src substrate peptide (AEEEIYGEFEAKKKK) and denatured enolase, showed that the overall activity (kcat) of the Src-CD molecule is about 10 times higher than that of wild-type Src.	Cadmium	169-171	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	55-58
8856081-8	1996	Kinetic measurements for two exogenous substrates, the Src substrate peptide (AEEEIYGEFEAKKKK) and denatured enolase, showed that the overall activity (kcat) of the Src-CD molecule is about 10 times higher than that of wild-type Src.	Cadmium	169-171	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	165-168
8856081-8	1996	Kinetic measurements for two exogenous substrates, the Src substrate peptide (AEEEIYGEFEAKKKK) and denatured enolase, showed that the overall activity (kcat) of the Src-CD molecule is about 10 times higher than that of wild-type Src.	Cadmium	169-171	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	165-168
8875326-4	1996	Both populations of DRMCs are enriched for cholesterol, ganglioside GM1, total kinase and tyrosine kinase activities, and c-Src and c-Fyn.	drmcs	20-25	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	122-127
8756661-4	1996	Utilizing ZAP-70- and Syk-deficient lymphocytes (Syk-DT40 cells), we provide biochemical and functional evidence that heterologous trans-phosphorylation of Tyr-493 by a Src-PTK is required for antigen receptor-mediated activation of both the calcium and ras pathways.	Tyrosine	156-159	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	169-172
8647927-5	1996	In this study, I detect a transient down-regulation of p90RSK activity that is inducible in cultures at the late stage of the src-induced cellular transformation by an increase of extracellular pH value from 7 to 8 and unidentified components in DMEM, but not in cultures which are at the early stage.	dmem	246-250	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	126-129
8537387-3	1995	We have shown that suppression of a certain fraction of c-Src activity by Csk may require the binding of Csk to tyrosine-phosphorylated paxillin.	Tyrosine	112-120	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	56-61
8648698-3	1996	We have previously shown that mutagenesis of the nonconsensus src polypyrimidine tract to a 14-nucleotide uninterrupted polypyrimidine tract results in an oversplicing phenotype and a concomitant defective replication in permissive chicken embryo fibroblasts.	polypyrimidine	66-80	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	62-65
8648698-3	1996	We have previously shown that mutagenesis of the nonconsensus src polypyrimidine tract to a 14-nucleotide uninterrupted polypyrimidine tract results in an oversplicing phenotype and a concomitant defective replication in permissive chicken embryo fibroblasts.	14-nucleotide	92-105	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	62-65
8648698-3	1996	We have previously shown that mutagenesis of the nonconsensus src polypyrimidine tract to a 14-nucleotide uninterrupted polypyrimidine tract results in an oversplicing phenotype and a concomitant defective replication in permissive chicken embryo fibroblasts.	polypyrimidine	120-134	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	62-65
8621681-3	1996	Increased tyrosine phosphorylation of these proteins is also observed in cells expressing a transforming chicken c-Src (mutant Phe-527) and in cells with the activated tyrosine kinase domains of the Drosophila insulin receptor, human insulin-like growth factor I receptor, and human insulin receptor-related receptor.	Phenylalanine	127-130	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	113-118
7525552-1	1994	Using a panel of src mutants partially defective for malignant transformation, our laboratory has previously identified the insulin-like growth factor (IGF-I) receptor as a protein whose tyrosine phosphorylation correlates with transformation by src in embryonic chick cells (Kozma et al., 1990; Kozma and Weber, 1990).	Tyrosine	187-195	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	17-20
7784071-3	1995	v-Src activity both stimulates tyrosine phosphorylation of a tyrosine kinase present in focal adhesions (focal adhesion kinase or pp125FAK) and disrupts focal adhesions, leading to cell rounding and detachment.	Tyrosine	31-39	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	2-5
7784071-6	1995	An efficiently transforming v-Src mutant initially stimulated pp125FAK tyrosine phosphorylation, but induced subsequent pp125FAK degradation prior to the onset of cell rounding and detachment.	Tyrosine	71-79	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	30-33
8621681-3	1996	Increased tyrosine phosphorylation of these proteins is also observed in cells expressing a transforming chicken c-Src (mutant Phe-527) and in cells with the activated tyrosine kinase domains of the Drosophila insulin receptor, human insulin-like growth factor I receptor, and human insulin receptor-related receptor.	Tyrosine	10-18	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	113-118
7794790-7	1995	When these morphologically altered CEF were challenged by superinfection with oncogenic retroviruses, they were resistant to transformation by the nuclear oncogenes jun, fos, junD, myc, and qin but were readily transformed by cytoplasmic oncogenes src, mil/raf, ras, and fps.	cef	35-38	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	248-251
7525552-1	1994	Using a panel of src mutants partially defective for malignant transformation, our laboratory has previously identified the insulin-like growth factor (IGF-I) receptor as a protein whose tyrosine phosphorylation correlates with transformation by src in embryonic chick cells (Kozma et al., 1990; Kozma and Weber, 1990).	Tyrosine	187-195	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	246-249
7505391-2	1994	In this report, we present evidence for the stable association of two Src family kinases (pp60src and pp59fyn) with tyrosine-phosphorylated forms of a focal adhesion-associated protein tyrosine kinase, pp125FAK.	Tyrosine	116-124	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	70-73
7933110-7	1994	Thus, like mutant alleles of c-src encoding transformation competent proteins, and unlike v-src, transformation by pp60v-src-F172 delta and pp60v-src-L186F is dependent on phosphorylation of Y-416 for high kinase activity and transformation ability.	y-416	191-196	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	29-34
7519604-1	1994	Chicken protein-tyrosine phosphatase lambda dephosphorylates c-Src tyrosine 527.	Tyrosine	16-24	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	61-66
7519604-8	1994	Analysis by cyanogen bromide cleavage showed that ChPTP lambda and myrPTP lambda dephosphorylated Tyr-527 of c-Src.	Cyanogen Bromide	12-28	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	109-114
7519604-8	1994	Analysis by cyanogen bromide cleavage showed that ChPTP lambda and myrPTP lambda dephosphorylated Tyr-527 of c-Src.	Tyrosine	98-101	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	109-114
7519604-9	1994	Our data demonstrated the different activities of three PTPs on phosphoproteins, suggesting that Src Tyr-527 may require more specific PTP(s) than Src Tyr-416 for dephosphorylation in vivo.	Tyrosine	101-104	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	97-100
7519604-9	1994	Our data demonstrated the different activities of three PTPs on phosphoproteins, suggesting that Src Tyr-527 may require more specific PTP(s) than Src Tyr-416 for dephosphorylation in vivo.	Tyrosine	101-104	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	147-150
7519604-9	1994	Our data demonstrated the different activities of three PTPs on phosphoproteins, suggesting that Src Tyr-527 may require more specific PTP(s) than Src Tyr-416 for dephosphorylation in vivo.	Tyrosine	151-154	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	97-100
7519604-9	1994	Our data demonstrated the different activities of three PTPs on phosphoproteins, suggesting that Src Tyr-527 may require more specific PTP(s) than Src Tyr-416 for dephosphorylation in vivo.	Tyrosine	151-154	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	147-150
7511598-5	1994	Since Src and other tyrosine kinases may participate in regulating events in mitosis, we used the SH2-binding probe to test the prediction that decreased tyrosine 527 phosphorylation would lead to increased accessibility of the c-Src SH2-domain during mitosis.	Tyrosine	20-28	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	228-233
7505391-6	1994	Furthermore, the association of isolated SH2 or SH3/SH2 domains with in vitro 32P-labeled pp125FAK protected the major site of pp125FAK autophosphorylation from digestion with a tyrosine phosphatase, indicating that the autophosphorylation site of pp125FAK participates in binding with Src.	Phosphorus-32	78-81	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	286-289
7505391-7	1994	Immunoprecipitation of Src family kinases from extracts of normal chicken embryo cells revealed stable complexes of pp59fyn and tyrosine-phosphorylated pp125FAK.	pp59fyn	116-123	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	23-26
7505391-7	1994	Immunoprecipitation of Src family kinases from extracts of normal chicken embryo cells revealed stable complexes of pp59fyn and tyrosine-phosphorylated pp125FAK.	Tyrosine	128-136	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	23-26
8247004-1	1993	Transformation of chicken embryo cells by oncogenic forms of pp60src (e.g., pp60v-src or pp60527F) is linked with a concomitant increase in the steady-state levels of tyrosine-phosphorylated cellular proteins.	Tyrosine	167-175	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	65-68
8247004-2	1993	Activated forms of the Src protein-tyrosine kinase stably associate with tyrosine-phosphorylated proteins, including a protein of 110 kDa, pp110.	Tyrosine	35-43	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	23-26
1321277-2	1992	A recombinant with a 5" end from src and a 3" end from ros, called SRC x ROS, transformed chicken embryo fibroblasts (CEF) to a spindle shape morphology, mimicking that of UR2.	ros	55-58	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	67-70
7681158-8	1993	The data suggest that a kinase-active form of pp60c-src located in the cytoskeleton of crypt cells may be responsible for phosphorylating proteins on tyrosine and regulating growth and differentiation of the cells.	Tyrosine	150-158	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	46-55
7689147-1	1993	Fibroblasts transformed by v-src or by related oncogenes encoding activated tyrosine kinases contain elevated levels of polyphosphoinositides with phosphate at the D-3 position of the inositol ring, as a result of the activation of phosphatidylinositol (PI) 3"-kinase.	Phosphatidylinositol Phosphates	120-141	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	29-32
7689147-1	1993	Fibroblasts transformed by v-src or by related oncogenes encoding activated tyrosine kinases contain elevated levels of polyphosphoinositides with phosphate at the D-3 position of the inositol ring, as a result of the activation of phosphatidylinositol (PI) 3"-kinase.	Phosphates	147-156	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	29-32
7689147-1	1993	Fibroblasts transformed by v-src or by related oncogenes encoding activated tyrosine kinases contain elevated levels of polyphosphoinositides with phosphate at the D-3 position of the inositol ring, as a result of the activation of phosphatidylinositol (PI) 3"-kinase.	Inositol	184-192	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	29-32
7689147-1	1993	Fibroblasts transformed by v-src or by related oncogenes encoding activated tyrosine kinases contain elevated levels of polyphosphoinositides with phosphate at the D-3 position of the inositol ring, as a result of the activation of phosphatidylinositol (PI) 3"-kinase.	Phosphatidylinositols	232-252	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	29-32
7689147-2	1993	v-src-transformed cells also contain increased levels of PI 3"-kinase activity immunoprecipitable with anti-phosphotyrosine antibodies; furthermore, PI 3"-kinase can be detected in association with the v-Src tyrosine kinase.	Phosphotyrosine	108-123	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	2-5
7689147-2	1993	v-src-transformed cells also contain increased levels of PI 3"-kinase activity immunoprecipitable with anti-phosphotyrosine antibodies; furthermore, PI 3"-kinase can be detected in association with the v-Src tyrosine kinase.	Phosphotyrosine	108-123	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	204-207
7688738-0	1993	Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine.	Tyrosine	101-109	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	30-33
7688738-1	1993	A current model for the regulation of the Src protein-tyrosine kinase proposes that the COOH-terminal phosphotyrosine, Tyr-527, binds to the Src homology 2 (SH2) region in an intramolecular interaction that represses the kinase domain.	Phosphotyrosine	102-117	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	42-45
7688738-1	1993	A current model for the regulation of the Src protein-tyrosine kinase proposes that the COOH-terminal phosphotyrosine, Tyr-527, binds to the Src homology 2 (SH2) region in an intramolecular interaction that represses the kinase domain.	Phosphotyrosine	102-117	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	141-144
7688738-1	1993	A current model for the regulation of the Src protein-tyrosine kinase proposes that the COOH-terminal phosphotyrosine, Tyr-527, binds to the Src homology 2 (SH2) region in an intramolecular interaction that represses the kinase domain.	Tyrosine	119-122	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	42-45
7688738-1	1993	A current model for the regulation of the Src protein-tyrosine kinase proposes that the COOH-terminal phosphotyrosine, Tyr-527, binds to the Src homology 2 (SH2) region in an intramolecular interaction that represses the kinase domain.	Tyrosine	119-122	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	141-144
7688738-14	1993	The SH3 domain is needed for Src to be inhibited when Tyr-527 is phosphorylated by Csk.	Tyrosine	54-57	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	29-32
8510932-11	1993	Phosphorylation of amino-terminal serines 63 and 73 on peptides Y and X, believed to be responsible for regulation of the transactivation function of c-Jun, is constitutively high in resting CEF cultures; stimulation with serum or v-Src results in only a modest increase in phosphorylation at these sites.	Serine	34-41	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	233-236
7680096-4	1993	Also, we show that an amino-terminal mutation that prevents myristylation (and membrane localization) of c-Src does not interfere with the p34cdc2-mediated phosphorylations but blocks both mitotic dephosphorylation of Tyr-527 (in kinase-defective Src) and stimulation of c-Src kinase activity.	Tyrosine	218-221	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	105-110
7680096-4	1993	Also, we show that an amino-terminal mutation that prevents myristylation (and membrane localization) of c-Src does not interfere with the p34cdc2-mediated phosphorylations but blocks both mitotic dephosphorylation of Tyr-527 (in kinase-defective Src) and stimulation of c-Src kinase activity.	Tyrosine	218-221	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	107-110
7680096-5	1993	Furthermore, in unsynchronized cells, the kinase activity of nonmyristylated c-Src is suppressed by 60% relative to wild-type c-Src, presumably because of increased Tyr-527 phosphorylation.	Tyrosine	165-168	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	77-82
7680096-6	1993	Consistent with this, the Tyr-527 dephosphorylation rate measured in cell homogenates is much higher for wild-type, myristylated c-Src than for nonmyristylated c-Src.	Tyrosine	26-29	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	129-134
7680096-6	1993	Consistent with this, the Tyr-527 dephosphorylation rate measured in cell homogenates is much higher for wild-type, myristylated c-Src than for nonmyristylated c-Src.	Tyrosine	26-29	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	160-165
7680096-8	1993	These findings suggest that the phosphatase(s) that acts on Tyr-527 is membrane bound and indicate that membrane localization of c-Src is necessary for its mitotic activation by dephosphorylation of Tyr-527.	Tyrosine	60-63	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	129-134
7680096-8	1993	These findings suggest that the phosphatase(s) that acts on Tyr-527 is membrane bound and indicate that membrane localization of c-Src is necessary for its mitotic activation by dephosphorylation of Tyr-527.	Tyrosine	199-202	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	129-134
1321277-2	1992	A recombinant with a 5" end from src and a 3" end from ros, called SRC x ROS, transformed chicken embryo fibroblasts (CEF) to a spindle shape morphology, mimicking that of UR2.	ros	73-76	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	67-70
1321277-2	1992	A recombinant with a 5" end from src and a 3" end from ros, called SRC x ROS, transformed chicken embryo fibroblasts (CEF) to a spindle shape morphology, mimicking that of UR2.	UR2	172-175	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	67-70
1321277-4	1992	However, a transforming variant of ROS x SRC II appeared during passages of the transfected cells and was called ROS x SRC (R).	ros	35-38	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	41-44
1321277-4	1992	However, a transforming variant of ROS x SRC II appeared during passages of the transfected cells and was called ROS x SRC (R).	ros	113-116	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	41-44
1549129-7	1992	Src substrates p36, p85, p120, p125, the GTPase-activating protein (GAP), and several GAP-associated proteins were phosphorylated on tyrosine in cells expressing the A, B, or C box deletion mutant.	Tyrosine	133-141	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	0-3
1378585-6	1992	Tyrosine kinase activity of a src-related kinase could be detected in adult sponges but not in their resting form (gemmulae), and may reflect the activity of the srk protein products.	gemmulae	115-123	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	30-33
1312616-0	1992	v-Src enhances phosphorylation at Ser-282 of the Rous sarcoma virus integrase.	Serine	34-37	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	2-5
1372437-1	1992	Cloning and sequencing of chicken C-terminal Src kinase (CSK), a tyrosine kinase that phosphorylates the regulatory C-terminal tyrosine residue present on cytoplasmic tyrosine kinases of the Src family, demonstrated a high degree of interspecies conservation as well as src homology 2 and 3 domains N-terminal to the kinase domain.	Tyrosine	65-73	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	45-48
1372011-8	1992	Phosphotyrosine-modified proteins that were potential targets of pp60c-src increased following nerve crush, and were localized to outgrowing neurites as well as to nonneuronal cells.	Phosphotyrosine	0-15	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	65-74
1372401-0	1992	Tyrosine phosphorylation of a 120,000 dalton membrane-associated protein by the neural form of pp60c-src, pp60c-src+.	Tyrosine	0-8	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	95-104
1372401-0	1992	Tyrosine phosphorylation of a 120,000 dalton membrane-associated protein by the neural form of pp60c-src, pp60c-src+.	Tyrosine	0-8	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	106-115
1372401-4	1992	Previous reports indicate that the profiles of proteins phosphorylated on tyrosine in chick embryo fibroblast (CEF) cells by pp60c-src+ or pp60c-src are equivalent.	Tyrosine	74-82	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	125-134
1372401-4	1992	Previous reports indicate that the profiles of proteins phosphorylated on tyrosine in chick embryo fibroblast (CEF) cells by pp60c-src+ or pp60c-src are equivalent.	Tyrosine	74-82	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	139-148
1372401-6	1992	Most substrates examined were phosphorylated on tyrosine to equivalent levels in CEF cells expressing either the neural- or fibroblast-specific src gene products.	Tyrosine	48-56	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	144-147
1372401-7	1992	However, the relative extent of tyrosine phosphorylation of a 120 kDa protein (p120) was increased in cells expressing the neuronal forms of either c-src or c-src527F.	Tyrosine	32-40	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	148-153
1710979-1	1991	Transformation of chicken embryo cells with the tyrosine kinase oncogene src results in the tyrosine phosphorylation of numerous cellular proteins.	Tyrosine	48-56	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	73-76
1875932-1	1991	The increase in glucose transport that occurs when chicken embryo fibroblasts (CEFs) are transformed by src is associated with an increase in the amount of type 1 glucose transporter protein, and we have previously shown that this effect is due to a decrease in the degradation rate of this protein.	Glucose	16-23	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	104-107
1875932-11	1991	We conclude that src regulates glucose transport in CEFs simultaneously by two different mechanisms.	Glucose	31-38	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	17-20
1710979-2	1991	We have recently generated monoclonal antibodies to individual tyrosine phosphorylated cellular src substrates, several of which are directed to the phosphotyrosine-containing proteins p130 and p110.	Tyrosine	63-71	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	96-99
1710979-9	1991	These data indicate that tyrosine phosphorylation of two different phosphoproteins may play a role during src transformation either by directing their interaction with pp60src, by redirecting subcellular distribution or both.	Tyrosine	25-33	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	106-109
1848666-1	1991	When purified p60v-src was mixed with lysates of chicken embryo fibroblasts and immunoprecipitated with anti-Src antibody, phosphatidylinositol (PI)-3 kinase activity was found to be present in the Src protein immunoprecipitates.	Phosphatidylinositols	123-143	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	19-22
1848666-1	1991	When purified p60v-src was mixed with lysates of chicken embryo fibroblasts and immunoprecipitated with anti-Src antibody, phosphatidylinositol (PI)-3 kinase activity was found to be present in the Src protein immunoprecipitates.	Phosphatidylinositols	123-143	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	109-112
1848666-1	1991	When purified p60v-src was mixed with lysates of chicken embryo fibroblasts and immunoprecipitated with anti-Src antibody, phosphatidylinositol (PI)-3 kinase activity was found to be present in the Src protein immunoprecipitates.	Phosphatidylinositols	123-143	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	198-201
1848666-4	1991	This change most likely resulted from tyrosine phosphorylation of PI-3 kinase or an associated protein, since the PI-3 kinase activity that can bind to p60v-src was depleted by antiphosphotyrosine antibody.	Tyrosine	38-46	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	157-160
1699227-0	1990	Overexpression of c-src enhances beta-adrenergic-induced cAMP accumulation.	Cyclic AMP	57-61	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	18-23
1699227-1	1990	During our investigations into the physiological role of c-src tyrosine kinase in normal cells, we found that clonal transfectants of C3H10T1/2 murine fibroblasts overexpressing chicken c-src exhibited strikingly elevated levels of cAMP accumulation in response to adrenergic stimulation as compared to control cells.	Cyclic AMP	232-236	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	57-62
1699227-6	1990	Only clones with abundant wild-type c-src protein (greater than 10-fold above endogenous) exhibited enhanced cAMP accumulation, averaging 3.3-fold above control cells.	Cyclic AMP	109-113	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	36-41
1699227-7	1990	We conclude, therefore, that the enhanced degree of cAMP accumulation in cells overexpressing c-src is dependent upon activation of beta-adrenergic receptors and upon a threshold level of pp60c-src that retains full tyrosine kinase activity.	Cyclic AMP	52-56	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	94-99
2162482-3	1990	9E3 mRNA was also increased in CEF in response to several agents which modulate phosphorylation, including phorbol myristic acetate, vanadate, and okadaic acid, which suggests that the rapid induction of 9E3 mRNA expression in CEF by the src protein occurs downstream of morphological or phosphorylation events.	cef	31-34	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	238-241
2115117-7	1990	The first reading frame of the 3.0-kb mRNA, called sur (for src upstream region), encoded a 24-kilodalton (kDa) protein product rich in cysteine and proline residues.	Cysteine	136-144	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	60-63
2115117-7	1990	The first reading frame of the 3.0-kb mRNA, called sur (for src upstream region), encoded a 24-kilodalton (kDa) protein product rich in cysteine and proline residues.	Proline	149-156	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	60-63
2162482-3	1990	9E3 mRNA was also increased in CEF in response to several agents which modulate phosphorylation, including phorbol myristic acetate, vanadate, and okadaic acid, which suggests that the rapid induction of 9E3 mRNA expression in CEF by the src protein occurs downstream of morphological or phosphorylation events.	Okadaic Acid	147-159	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	238-241
2111444-2	1990	Chicken embryo fibroblasts infected with a p60c-src variant containing arginine instead of tryptophan at residue 148 (W148R) appeared more rounded than cells overexpressing a normal c-src gene, and they formed colonies in soft agar.	Agar	227-231	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	48-51
34616310-10	2021	These two pools may represent two or more signaling pathways, namely, one pathway downstream of Src activated by tyrosine-416 phosphorylation and another upstream of Src, keeping the enzyme in an inactivated state via phosphorylation of tyrosine-527.	Tyrosine	113-121	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	96-99
34616310-10	2021	These two pools may represent two or more signaling pathways, namely, one pathway downstream of Src activated by tyrosine-416 phosphorylation and another upstream of Src, keeping the enzyme in an inactivated state via phosphorylation of tyrosine-527.	Tyrosine	237-245	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	96-99
34616310-10	2021	These two pools may represent two or more signaling pathways, namely, one pathway downstream of Src activated by tyrosine-416 phosphorylation and another upstream of Src, keeping the enzyme in an inactivated state via phosphorylation of tyrosine-527.	Tyrosine	237-245	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	166-169
2476666-1	1989	We have identified two phosphotyrosine-containing cellular proteins with relative molecular masses of 130,000 (pp130) and 110,000 (pp110) daltons in chicken embryo cells that coimmunoprecipitated with pp60v-src and activated forms of chicken pp60c-src (pp60(527)F).	Phosphotyrosine	23-38	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	207-210
34440937-7	2021	Conditioned medium from S1P-treated osteoblasts significantly increased EPC tube formation and migration by inhibiting miR-16-5p synthesis via proto-oncogene tyrosine-protein kinase src (c-Src) and FAK signaling in chick chorioallantoic membrane (CAM) and Matrigel plug assays.	mir-16-5p	119-128	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	187-192
35625853-7	2022	However, the communication between Wnt signaling and Src tyrosine kinase has not been well reviewed as Src regulates Wnt signaling through LRP6 tyrosine phosphorylation.	Tyrosine	144-152	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	103-106
2480346-1	1989	We recently identified a novel protein tyrosine kinase that specifically phosphorylates truncated pp60c-src (Mr = 53,000) at a tyrosine residue(s) distinct from its autophosphorylation site.	Tyrosine	39-47	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	98-107
2480346-4	1989	The novel kinase phosphorylated tyrosine residues of both forms of intact pp60c-src.	Tyrosine	32-40	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	74-83
2480346-6	1989	The enzyme also phosphorylated pp60c-src in which the kinase activity had been destroyed by an ATP analogue, p-fluorosulfonylbenzoyl 5"-adenosine.	Adenosine Triphosphate	95-98	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	31-40
2480346-6	1989	The enzyme also phosphorylated pp60c-src in which the kinase activity had been destroyed by an ATP analogue, p-fluorosulfonylbenzoyl 5"-adenosine.	5'-(4-fluorosulfonylbenzoyl)adenosine	109-145	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	31-40
2476666-1	1989	We have identified two phosphotyrosine-containing cellular proteins with relative molecular masses of 130,000 (pp130) and 110,000 (pp110) daltons in chicken embryo cells that coimmunoprecipitated with pp60v-src and activated forms of chicken pp60c-src (pp60(527)F).	Phosphotyrosine	23-38	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	242-251
2476666-3	1989	Consequently, of the more than 15 prominent phosphoproteins detected on immunoblots with phosphotyrosine-specific antibodies, pp130 and pp110 were selectively removed by src protein-specific immunoprecipitation, and their presence in the immunoprecipitates appears to have been due to a direct interaction with activated src proteins.	Phosphotyrosine	89-104	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	170-173
2476666-5	1989	Mutant src proteins, defective for myristylation, showed increased tyrosine phosphorylation of and association with pp110.	Tyrosine	67-75	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	7-10
2469003-0	1989	Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.	Tyrosine	24-32	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	146-149
2477684-2	1989	There are two structural alterations present in the amino-terminal half of pp60c-src+ expressed in neurons which could contribute to the enhanced activity of this form of pp60c-src: (i) a hexapeptide insert located at amino acid 114 of avian pp60c-src+ and (ii) a novel site(s) of serine phosphorylation.	Serine	281-287	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	75-84
2477684-2	1989	There are two structural alterations present in the amino-terminal half of pp60c-src+ expressed in neurons which could contribute to the enhanced activity of this form of pp60c-src: (i) a hexapeptide insert located at amino acid 114 of avian pp60c-src+ and (ii) a novel site(s) of serine phosphorylation.	Serine	281-287	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	171-180
2477684-2	1989	There are two structural alterations present in the amino-terminal half of pp60c-src+ expressed in neurons which could contribute to the enhanced activity of this form of pp60c-src: (i) a hexapeptide insert located at amino acid 114 of avian pp60c-src+ and (ii) a novel site(s) of serine phosphorylation.	Serine	281-287	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	171-180
2477684-5	1989	The major sites of phosphorylation of the c-src+ protein were Ser-17 and Tyr-527.	Serine	62-65	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	42-47
2477684-5	1989	The major sites of phosphorylation of the c-src+ protein were Ser-17 and Tyr-527.	Tyrosine	73-76	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	42-47
2477684-6	1989	The unique site(s) of serine phosphorylation originally identified in pp60c-src+ expressed in neurons was not detected in the c-src+ protein overexpressed in CEFs.	Serine	22-28	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	70-79
2477684-6	1989	The unique site(s) of serine phosphorylation originally identified in pp60c-src+ expressed in neurons was not detected in the c-src+ protein overexpressed in CEFs.	Serine	22-28	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	74-79
2470512-1	1989	We have previously shown that overexpressed chicken pp60c-src has retarded mobility, novel serine/threonine phosphorylation, and enhanced kinase activity during NIH 3T3 cell mitosis.	Serine	91-97	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	52-61
2470512-1	1989	We have previously shown that overexpressed chicken pp60c-src has retarded mobility, novel serine/threonine phosphorylation, and enhanced kinase activity during NIH 3T3 cell mitosis.	Threonine	98-107	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	52-61
2565821-4	1989	Such reduced translocation of DG kinase by TPA is also observed in src-transformed cells, but not in myc-transformed cells.	Tetradecanoylphorbol Acetate	43-46	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	67-70
2471064-6	1989	Neomycin-resistant clonal cell lines overexpressing each of the mutated c-src genes were assayed for EGF mitogenic responsiveness by measuring [3H]thymidine incorporation into acid-precipitable material or into labeled nuclei.	Neomycin	0-8	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	72-77
2476707-1	1989	To further investigate regulation of p60src by tyrosine phosphorylation, the in vivo phosphorylation states and kinase activities of transforming mutants derived from p60c-src were examined.	Tyrosine	47-55	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	37-43
2447487-1	1988	C3H10T1/2 murine fibroblasts overexpressing chicken pp60c-src showed a two- to fivefold enhanced incorporation of [3H]thymidine into DNA in response to epidermal growth factor (EGF) relative to that of the parent line.	Tritium	1-3	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	52-61
2454397-1	1988	pp60c-src is phosphorylated mainly on Ser-17 and Tyr-527 in vivo.	Serine	38-41	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	0-9
2454397-1	1988	pp60c-src is phosphorylated mainly on Ser-17 and Tyr-527 in vivo.	Tyrosine	49-52	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	0-9
2454397-2	1988	In this study, we examined the effect of the phosphorylation of Ser-17 on the properties of pp60c-src by introducing Rous sarcoma virus variants carrying pp60c-src in which Ser-17 had been substituted, into chicken embryo fibroblasts.	Serine	64-67	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	92-101
2454397-3	1988	The Ala-17 substitution in wild-type pp60c-src and pp60c-src carrying Phe-527 caused a two- to threefold elevation in the kinase activity in vitro of these proteins; the former variant resulted in no morphological changes of infected cells, whereas the latter variant transformed chicken embryo fibroblasts.	Alanine	4-7	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	37-46
2454397-3	1988	The Ala-17 substitution in wild-type pp60c-src and pp60c-src carrying Phe-527 caused a two- to threefold elevation in the kinase activity in vitro of these proteins; the former variant resulted in no morphological changes of infected cells, whereas the latter variant transformed chicken embryo fibroblasts.	Alanine	4-7	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	51-60
2454397-3	1988	The Ala-17 substitution in wild-type pp60c-src and pp60c-src carrying Phe-527 caused a two- to threefold elevation in the kinase activity in vitro of these proteins; the former variant resulted in no morphological changes of infected cells, whereas the latter variant transformed chicken embryo fibroblasts.	Phenylalanine	70-73	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	51-60
2454397-4	1988	Since the substitution of Tyr-527 per se has been reported to activate pp60c-src, these results suggest that the abolishment of the phosphorylation of Ser-17 does not affect noticeably the properties of pp60c-src in chicken embryo fibroblasts.	Tyrosine	26-29	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	71-80
2452399-5	1988	Chicken pp60c-src expressed in an asbestos-transformed, tumor-derived cell line showed an approximate 3-fold activation of tyrosine kinase activity compared to chicken pp60c-src expressed in the preneoplastic cell line.	Asbestos	34-42	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	8-17
2441875-0	1987	Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region.	Adenosine Triphosphate	52-55	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	28-31
3336355-0	1988	Transformation by the src oncogene alters glucose transport into rat and chicken cells by different mechanisms.	Glucose	42-49	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	22-25
3336355-1	1988	Transformation of both rat and chicken fibroblasts by the src oncogene leads to a four- to fivefold increase in the rate of glucose transport and in the level of the glucose transporter protein.	Glucose	124-131	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	58-61
3336355-7	1988	Thus, src induced an increase in the level of the glucose transport protein by fundamentally different mechanisms in chicken embryo fibroblasts and rat-1 cells.	Glucose	50-57	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	6-9
2441875-1	1987	Cellular src protein, p60c-src, is phosphorylated on tyrosine 527 in chicken embryo fibroblasts, and this phosphorylation is implicated in suppressing the protein-tyrosine kinase activity and transforming potential of p60c-src.	Tyrosine	53-61	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	9-12
2441875-1	1987	Cellular src protein, p60c-src, is phosphorylated on tyrosine 527 in chicken embryo fibroblasts, and this phosphorylation is implicated in suppressing the protein-tyrosine kinase activity and transforming potential of p60c-src.	Tyrosine	53-61	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	27-30
2441875-1	1987	Cellular src protein, p60c-src, is phosphorylated on tyrosine 527 in chicken embryo fibroblasts, and this phosphorylation is implicated in suppressing the protein-tyrosine kinase activity and transforming potential of p60c-src.	Tyrosine	53-61	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	27-30
2441875-2	1987	To determine whether tyrosine 527 phosphorylation is dependent on p60c-src kinase activity, the ATP-binding site of chicken p60c-src was destroyed by substitution of lysine 295 with methionine.	Tyrosine	21-29	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	129-132
2441875-2	1987	To determine whether tyrosine 527 phosphorylation is dependent on p60c-src kinase activity, the ATP-binding site of chicken p60c-src was destroyed by substitution of lysine 295 with methionine.	Adenosine Triphosphate	96-99	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	129-132
2441875-4	1987	Nevertheless, tyrosine and serine phosphorylation of p60c-src(M295) overproduced in chicken cells were indistinguishable from that of authentic p60c-src.	Serine	27-33	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	58-61
2441608-2	1987	The erythrocyte protein kinase phosphorylated heavy chains of tumor-bearing rabbit (TBR) antibodies reactive with pp60c-src at tyrosine in immune complex protein kinase assays.	Tyrosine	127-135	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	114-123
2439902-1	1987	The rate of glucose transport in cultured fibroblasts is regulated to a number of physiological variables, including malignant transformation by src, glucose starvation, and stimulation with mitogens.	Glucose	12-19	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	145-148
2822389-1	1987	The role of tyrosine phosphorylation in the regulation of tyrosine protein kinase activity was investigated using site-directed mutagenesis to alter the structure and environment of the three tyrosine residues present in the C terminus of avian pp60c-src.	Tyrosine	58-66	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	245-254
2822389-3	1987	In contrast, alterations of tyrosine residues present at positions 511 or 519 in c-src do not induce transformation or in vivo tyrosine protein kinase activity.	Tyrosine	28-36	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	81-86
2822389-4	1987	Amber mutations, which alter the structure of the pp60c-src C terminus by inducing premature termination of the c-src protein at either residue 518 or 523 also induce morphological transformation and increase in vivo tyrosine phosphorylation, whereas removal of the last four residues of c-src by chain termination at residue 530 does not alter the kinase activity or the biological activity of the resultant c-src protein.	Tyrosine	217-225	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	50-59
2822389-4	1987	Amber mutations, which alter the structure of the pp60c-src C terminus by inducing premature termination of the c-src protein at either residue 518 or 523 also induce morphological transformation and increase in vivo tyrosine phosphorylation, whereas removal of the last four residues of c-src by chain termination at residue 530 does not alter the kinase activity or the biological activity of the resultant c-src protein.	Tyrosine	217-225	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	54-59
2822389-4	1987	Amber mutations, which alter the structure of the pp60c-src C terminus by inducing premature termination of the c-src protein at either residue 518 or 523 also induce morphological transformation and increase in vivo tyrosine phosphorylation, whereas removal of the last four residues of c-src by chain termination at residue 530 does not alter the kinase activity or the biological activity of the resultant c-src protein.	Tyrosine	217-225	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	112-117
2822389-4	1987	Amber mutations, which alter the structure of the pp60c-src C terminus by inducing premature termination of the c-src protein at either residue 518 or 523 also induce morphological transformation and increase in vivo tyrosine phosphorylation, whereas removal of the last four residues of c-src by chain termination at residue 530 does not alter the kinase activity or the biological activity of the resultant c-src protein.	Tyrosine	217-225	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	112-117
2822389-5	1987	We conclude from these studies that C-terminal alterations which either remove or replace Tyr 527 serve to activate the c-src protein resulting in cellular transformation and increased in vivo tyrosine protein kinase activity.	Tyrosine	90-93	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	120-125
2440106-3	1987	This clone encodes a 60-kilodalton protein that differs from chicken or human pp60c-src primarily in having six extra amino acids (Arg-Lys-Val-Asp-Val-Arg) within the NH2-terminal 16 kilodaltons of the molecule.	Arginine	131-134	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	78-87
2440106-3	1987	This clone encodes a 60-kilodalton protein that differs from chicken or human pp60c-src primarily in having six extra amino acids (Arg-Lys-Val-Asp-Val-Arg) within the NH2-terminal 16 kilodaltons of the molecule.	Lysine	135-138	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	78-87
2440106-3	1987	This clone encodes a 60-kilodalton protein that differs from chicken or human pp60c-src primarily in having six extra amino acids (Arg-Lys-Val-Asp-Val-Arg) within the NH2-terminal 16 kilodaltons of the molecule.	Valine	139-142	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	78-87
2440106-3	1987	This clone encodes a 60-kilodalton protein that differs from chicken or human pp60c-src primarily in having six extra amino acids (Arg-Lys-Val-Asp-Val-Arg) within the NH2-terminal 16 kilodaltons of the molecule.	Aspartic Acid	143-146	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	78-87
2440106-3	1987	This clone encodes a 60-kilodalton protein that differs from chicken or human pp60c-src primarily in having six extra amino acids (Arg-Lys-Val-Asp-Val-Arg) within the NH2-terminal 16 kilodaltons of the molecule.	Valine	147-150	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	78-87
2440106-3	1987	This clone encodes a 60-kilodalton protein that differs from chicken or human pp60c-src primarily in having six extra amino acids (Arg-Lys-Val-Asp-Val-Arg) within the NH2-terminal 16 kilodaltons of the molecule.	Arginine	151-154	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	78-87
6609830-0	1984	Early release of the density-dependent inhibition of phosphate uptake and ATP synthesis after src gene expression in chick embryo fibroblasts.	Phosphates	53-62	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	94-97
2432397-4	1986	We found that the change from Thr to Ile at position 338 or the replacement of a fragment of c-src containing Gly-63, Arg-95, and Thr-96 with a corresponding fragment of v-src containing Asp-63, Trp-95, and Ile-96 converted p60c-src into a transforming protein by the criteria of focus formation, anchorage-independent growth, and tumor formation in newborn chickens.	Glycine	110-113	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	93-98
2432397-4	1986	We found that the change from Thr to Ile at position 338 or the replacement of a fragment of c-src containing Gly-63, Arg-95, and Thr-96 with a corresponding fragment of v-src containing Asp-63, Trp-95, and Ile-96 converted p60c-src into a transforming protein by the criteria of focus formation, anchorage-independent growth, and tumor formation in newborn chickens.	Glycine	110-113	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	95-98
2432397-4	1986	We found that the change from Thr to Ile at position 338 or the replacement of a fragment of c-src containing Gly-63, Arg-95, and Thr-96 with a corresponding fragment of v-src containing Asp-63, Trp-95, and Ile-96 converted p60c-src into a transforming protein by the criteria of focus formation, anchorage-independent growth, and tumor formation in newborn chickens.	Aspartic Acid	187-190	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	172-175
2419902-0	1986	Phosphorylation of tyrosine in the carboxyl-terminal tryptic peptide of pp60c-src.	Tyrosine	19-27	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	72-81
2419902-0	1986	Phosphorylation of tyrosine in the carboxyl-terminal tryptic peptide of pp60c-src.	Peptides	61-68	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	72-81
2419902-1	1986	The major site of tyrosine phosphorylation of the transforming protein of Rous sarcoma virus, pp60v-src (tyrosine-416), is different from the major site of tyrosine phosphorylation of its nontransforming normal cellular counterpart, pp60c-src.	Tyrosine	18-26	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	233-242
2419902-2	1986	We have shown that antibodies against a synthetic peptide modeled on the carboxyl-terminal 13 residues of pp60c-src specifically immunoprecipitate the major phosphotyrosine tryptic peptide of pp60c-src from both chicken and rat fibroblasts.	Phosphotyrosine	157-172	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	106-115
2419902-2	1986	We have shown that antibodies against a synthetic peptide modeled on the carboxyl-terminal 13 residues of pp60c-src specifically immunoprecipitate the major phosphotyrosine tryptic peptide of pp60c-src from both chicken and rat fibroblasts.	Phosphotyrosine	157-172	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	192-201
2419902-2	1986	We have shown that antibodies against a synthetic peptide modeled on the carboxyl-terminal 13 residues of pp60c-src specifically immunoprecipitate the major phosphotyrosine tryptic peptide of pp60c-src from both chicken and rat fibroblasts.	Peptides	50-57	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	106-115
2419902-2	1986	We have shown that antibodies against a synthetic peptide modeled on the carboxyl-terminal 13 residues of pp60c-src specifically immunoprecipitate the major phosphotyrosine tryptic peptide of pp60c-src from both chicken and rat fibroblasts.	Peptides	50-57	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	192-201
2419902-3	1986	These experiments localize the major site of tyrosine phosphorylation to one or more of the three tyrosine residues in the carboxyl-terminal tryptic peptide at positions 511, 519, and 527 of the amino acid sequence of chicken pp60c-src.	Tyrosine	45-53	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	226-235
2419902-3	1986	These experiments localize the major site of tyrosine phosphorylation to one or more of the three tyrosine residues in the carboxyl-terminal tryptic peptide at positions 511, 519, and 527 of the amino acid sequence of chicken pp60c-src.	Tyrosine	98-106	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	226-235
2419902-3	1986	These experiments localize the major site of tyrosine phosphorylation to one or more of the three tyrosine residues in the carboxyl-terminal tryptic peptide at positions 511, 519, and 527 of the amino acid sequence of chicken pp60c-src.	Peptides	149-156	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	226-235
2419902-4	1986	Tyrosines-519 and -527 are in the carboxyl-terminal 19-amino acid segment of pp60c-src that is deleted and replaced by an unrelated sequence in pp60v-src.	Tyrosine	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	77-86
2419902-5	1986	It is possible that phosphorylation of tyrosine in the carboxyl-terminal tryptic peptide may be involved in the normal regulation of pp60c-src.	Tyrosine	39-47	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	133-142
2419902-5	1986	It is possible that phosphorylation of tyrosine in the carboxyl-terminal tryptic peptide may be involved in the normal regulation of pp60c-src.	Peptides	81-88	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	133-142
2436039-0	1987	In vivo effect of sodium orthovanadate on pp60c-src kinase.	Sodium orthovanadate	18-38	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	42-51
2436039-1	1987	We have compared the tyrosine kinase activity of pp60c-src isolated from intact chicken embryo fibroblasts treated with micromolar sodium orthovanadate for 4 h and from untreated cells.	Sodium orthovanadate	131-151	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	49-58
2436039-3	1987	The reduction of in vitro enzymatic activity correlated with a vanadate-induced increase in in vivo phosphorylation of pp60c-src at the major site of tyrosine phosphorylation in the carboxyl-terminal half of the molecule and at serine in the amino-terminal half of the molecule.	Vanadates	63-71	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	119-128
2436039-3	1987	The reduction of in vitro enzymatic activity correlated with a vanadate-induced increase in in vivo phosphorylation of pp60c-src at the major site of tyrosine phosphorylation in the carboxyl-terminal half of the molecule and at serine in the amino-terminal half of the molecule.	Tyrosine	150-158	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	119-128
2436039-3	1987	The reduction of in vitro enzymatic activity correlated with a vanadate-induced increase in in vivo phosphorylation of pp60c-src at the major site of tyrosine phosphorylation in the carboxyl-terminal half of the molecule and at serine in the amino-terminal half of the molecule.	Serine	228-234	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	119-128
2436039-5	1987	4:1471-1477, 1985) suggest that vanadate may enhance a cellular regulatory mechanism that inhibits the activity of pp60c-src in normal cells.	Vanadates	32-40	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	115-124
2436039-6	1987	A likely candidate for this mechanism is phosphorylation at a tyrosine residue distinct from tyrosine 416, probably tyrosine 527 in the carboxyl-terminal sequence of amino acids unique to pp60c-src.	Tyrosine	62-70	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	188-197
2436039-9	1987	Assuming that pp60c-src is inhibited intracellularly by vanadate, either another tyrosine kinase is stimulated by vanadate (e.g., a growth factor receptor) or the 36-kilodalton phosphoprotein in normal cells is no longer rapidly dephosphorylated by a tyrosine phosphatase in the presence of vanadate.	Vanadates	56-64	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	14-23
2430174-4	1986	Lysine-295 in p60src was replaced with a glutamic acid, an arginine, or a histidine residue, and mutant p60src proteins were characterized in chicken cells infected by mutant viruses.	Lysine	0-6	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	14-20
2582237-15	1985	The focus-selected c-src overexpressed cells had altered morphology and limited growth in soft agarose but were not tumorigenic in vivo.	Sepharose	95-102	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	19-24
3920510-9	1985	Biochemical analyses of pp60c-src in the developing cerebellum by the immune complex protein kinase activity and sensitivity of the kinase to inhibition by P1,P4-di(adenosine-5")tetraphosphate confirmed that the expression of pp60c-src coincided with the time of neuronal differentiation.	p1,	156-159	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	24-33
3920510-9	1985	Biochemical analyses of pp60c-src in the developing cerebellum by the immune complex protein kinase activity and sensitivity of the kinase to inhibition by P1,P4-di(adenosine-5")tetraphosphate confirmed that the expression of pp60c-src coincided with the time of neuronal differentiation.	p4-di(adenosine-5")tetraphosphate	159-192	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	24-33
3920510-9	1985	Biochemical analyses of pp60c-src in the developing cerebellum by the immune complex protein kinase activity and sensitivity of the kinase to inhibition by P1,P4-di(adenosine-5")tetraphosphate confirmed that the expression of pp60c-src coincided with the time of neuronal differentiation.	p4-di(adenosine-5")tetraphosphate	159-192	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	226-235
6609830-1	1984	Our results showed that the expression of the src gene in chick embryo fibroblasts (CEF) released the density-dependent inhibition (DDI) of phosphate metabolism (phosphate uptake and phosphorylation of small organic compounds).	Phosphates	140-149	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	46-49
6609830-1	1984	Our results showed that the expression of the src gene in chick embryo fibroblasts (CEF) released the density-dependent inhibition (DDI) of phosphate metabolism (phosphate uptake and phosphorylation of small organic compounds).	Phosphates	162-171	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	46-49
6285367-6	1982	Tryptic phosphopeptide analysis demonstrated that the catalytic subunit phosphorylated a serine-containing tryptic peptide in the bacterial src protein that comigrated with the phosphoserine-containing tryptic peptide of pp60src immunoprecipitated from 32P-labeled PrA-RSV-infected chicken cells.	Serine	89-95	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	140-143
6285367-6	1982	Tryptic phosphopeptide analysis demonstrated that the catalytic subunit phosphorylated a serine-containing tryptic peptide in the bacterial src protein that comigrated with the phosphoserine-containing tryptic peptide of pp60src immunoprecipitated from 32P-labeled PrA-RSV-infected chicken cells.	Peptides	15-22	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	140-143
6285367-6	1982	Tryptic phosphopeptide analysis demonstrated that the catalytic subunit phosphorylated a serine-containing tryptic peptide in the bacterial src protein that comigrated with the phosphoserine-containing tryptic peptide of pp60src immunoprecipitated from 32P-labeled PrA-RSV-infected chicken cells.	Phosphoserine	177-190	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	140-143
6285367-6	1982	Tryptic phosphopeptide analysis demonstrated that the catalytic subunit phosphorylated a serine-containing tryptic peptide in the bacterial src protein that comigrated with the phosphoserine-containing tryptic peptide of pp60src immunoprecipitated from 32P-labeled PrA-RSV-infected chicken cells.	Peptides	115-122	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	140-143
6285367-6	1982	Tryptic phosphopeptide analysis demonstrated that the catalytic subunit phosphorylated a serine-containing tryptic peptide in the bacterial src protein that comigrated with the phosphoserine-containing tryptic peptide of pp60src immunoprecipitated from 32P-labeled PrA-RSV-infected chicken cells.	Phosphorus-32	253-256	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	140-143
6285367-6	1982	Tryptic phosphopeptide analysis demonstrated that the catalytic subunit phosphorylated a serine-containing tryptic peptide in the bacterial src protein that comigrated with the phosphoserine-containing tryptic peptide of pp60src immunoprecipitated from 32P-labeled PrA-RSV-infected chicken cells.	pra-rsv	265-272	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	140-143
6257928-6	1980	src protein kinase activity associated with plasma membrane fractions prepared from vole cells and ASV-infected chicken embryo fibroblasts was resistant to extraction with high salt concentrations, but partial elution was achieved with nonionic detergent.	Salts	177-181	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	0-3
33210912-0	2020	Novel Pentapeptide Derived from Chicken by-Product Ameliorates DSS-Induced Colitis by Enhancing Intestinal Barrier Function via AhR-Induced Src Inactivation.	Dextran Sulfate	63-66	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	140-143
33210912-4	2020	Our work demonstrated that aryl hydrocarbon receptor (AhR) activation by LP-5 could inhibit the Src kinase to increase tight junction protein levels and down-regulate the expression of inflammatory cytokines to protect the intestinal barrier and finally alleviate dextran sulfate sodium (DSS)-induced colitis.	lp-5	73-77	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	96-99
33210912-4	2020	Our work demonstrated that aryl hydrocarbon receptor (AhR) activation by LP-5 could inhibit the Src kinase to increase tight junction protein levels and down-regulate the expression of inflammatory cytokines to protect the intestinal barrier and finally alleviate dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	264-286	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	96-99
33210912-4	2020	Our work demonstrated that aryl hydrocarbon receptor (AhR) activation by LP-5 could inhibit the Src kinase to increase tight junction protein levels and down-regulate the expression of inflammatory cytokines to protect the intestinal barrier and finally alleviate dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	288-291	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	96-99