PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
12754197-6	2003	The second phase consisted of a sustained release of calcium from the vacuole via the calcium channel Yvc1 and was independent of extracellular Ca2+ entry.	Calcium	53-60	Yvc1p	Saccharomyces cerevisiae S288C	102-106
22153127-4	2012	Therefore the aim was also to investigate how the vacuole, through the participation of both Ca(2+)-ATPase Pmc1 and the TRP homologue calcium channel Yvc1 (respectively, encoded by the genes PMC1 and YVC1) contributes to control the intracellular calcium availability and the plasma membrane H(+)-ATPase activation in response to glucose.	Calcium	134-141	Yvc1p	Saccharomyces cerevisiae S288C	150-154
22153127-4	2012	Therefore the aim was also to investigate how the vacuole, through the participation of both Ca(2+)-ATPase Pmc1 and the TRP homologue calcium channel Yvc1 (respectively, encoded by the genes PMC1 and YVC1) contributes to control the intracellular calcium availability and the plasma membrane H(+)-ATPase activation in response to glucose.	Glucose	330-337	Yvc1p	Saccharomyces cerevisiae S288C	150-154
22153127-5	2012	In strains presenting a single deletion in YVC1 gene or a double deletion in YVC1 and PMC1 genes, both glucose-induced calcium signaling and activation of the H(+)-ATPase are nearly abolished.	Glucose	103-110	Yvc1p	Saccharomyces cerevisiae S288C	43-47
22153127-5	2012	In strains presenting a single deletion in YVC1 gene or a double deletion in YVC1 and PMC1 genes, both glucose-induced calcium signaling and activation of the H(+)-ATPase are nearly abolished.	Glucose	103-110	Yvc1p	Saccharomyces cerevisiae S288C	77-81
22153127-5	2012	In strains presenting a single deletion in YVC1 gene or a double deletion in YVC1 and PMC1 genes, both glucose-induced calcium signaling and activation of the H(+)-ATPase are nearly abolished.	Calcium	119-126	Yvc1p	Saccharomyces cerevisiae S288C	43-47
22153127-5	2012	In strains presenting a single deletion in YVC1 gene or a double deletion in YVC1 and PMC1 genes, both glucose-induced calcium signaling and activation of the H(+)-ATPase are nearly abolished.	Calcium	119-126	Yvc1p	Saccharomyces cerevisiae S288C	77-81
22153127-6	2012	These results suggest that Yvc1 calcium channel is an important component of this signal transduction pathway activated in response to glucose addition.	Glucose	135-142	Yvc1p	Saccharomyces cerevisiae S288C	27-31
22153127-7	2012	We also found that by a still undefined mechanism Yvc1 activation seems to correlate with the changes in the intracellular level of IP(3).	ip	132-134	Yvc1p	Saccharomyces cerevisiae S288C	50-54
22153127-8	2012	Taken together, these data demonstrate that glucose addition to yeast cells exposed to low external calcium concentrations affects calcium uptake and the activity of the vacuolar calcium channel Yvc1, contributing to the occurrence of calcium signaling connected to plasma membrane H(+)-ATPase activation.	Glucose	44-51	Yvc1p	Saccharomyces cerevisiae S288C	195-199
22153127-8	2012	Taken together, these data demonstrate that glucose addition to yeast cells exposed to low external calcium concentrations affects calcium uptake and the activity of the vacuolar calcium channel Yvc1, contributing to the occurrence of calcium signaling connected to plasma membrane H(+)-ATPase activation.	Calcium	100-107	Yvc1p	Saccharomyces cerevisiae S288C	195-199
32714312-13	2020	This study also found that the vacuolar calcium regulation genes YVC1 and PMC1 are key BBH + FLC targets which increase cytoplasmic Ca2+ in resistant isolates, which might be critical for reversing biofilm-positive FLC-resistant C. albicans.	Calcium	40-47	Yvc1p	Saccharomyces cerevisiae S288C	65-69
11427713-2	2001	We investigated a prominent voltage-dependent, cation-selective, and calcium-activated vacuolar ion conductance of 320 pS (yeast vacuolar conductance, YVC1) in Saccharomyces cerevisiae.	Calcium	69-76	Yvc1p	Saccharomyces cerevisiae S288C	151-155
34917046-3	2021	However, the relationship between Yvc1 and Cnb1-governed calcium ions and endoplasmic reticulum (ER) stress response remains unrevealed.	Calcium	57-64	Yvc1p	Saccharomyces cerevisiae S288C	34-38
34917046-7	2021	To verify the regulation role of Yvc1 in the calcium concentration, we found that the addition of CaCl2 led to the worse viability, while the growth state was relieved under the treatment of EGTA in the cnb1Delta/Delta strain.	Calcium	45-52	Yvc1p	Saccharomyces cerevisiae S288C	33-37
34917046-7	2021	To verify the regulation role of Yvc1 in the calcium concentration, we found that the addition of CaCl2 led to the worse viability, while the growth state was relieved under the treatment of EGTA in the cnb1Delta/Delta strain.	Calcium Chloride	98-103	Yvc1p	Saccharomyces cerevisiae S288C	33-37
34917046-7	2021	To verify the regulation role of Yvc1 in the calcium concentration, we found that the addition of CaCl2 led to the worse viability, while the growth state was relieved under the treatment of EGTA in the cnb1Delta/Delta strain.	Egtazic Acid	191-195	Yvc1p	Saccharomyces cerevisiae S288C	33-37
34917046-8	2021	In conclusion, the deletion of YVC1 could reduce the cellular calcium and relieve the ER stress sensitivity of the cnb1Delta/Delta strain.	Calcium	62-69	Yvc1p	Saccharomyces cerevisiae S288C	31-35
34917046-9	2021	Thereby, our findings shed a novel light on the relationship between the Yvc1-governed cellular calcium concentration and ER stress response in C. albicans.	Calcium	96-103	Yvc1p	Saccharomyces cerevisiae S288C	73-77
33412497-3	2021	The sustained elevation of cytoplasm calcium concentration with treatment time depended on the activated calcium channels of Cch1p/Mid1p in cell membrane and Yvc1p in vacuole membrane by these species.	Calcium	37-44	Yvc1p	Saccharomyces cerevisiae S288C	158-163
30427760-3	2019	PI(3,5)P2 is made by the PI3P 5-kinase Fab1 and has been characterized as a regulator of vacuole fission during hyperosmotic shock, where it interacts with the TRP Ca2+ channel Yvc1.	phosphatidyl (3,5) inositol biphosphate	0-9	Yvc1p	Saccharomyces cerevisiae S288C	177-181
32388897-2	2020	Yeast vacuoles under hyperosmotic stress become fragmented through fission events that requires the release of Ca2+ stores through the TRP channel Yvc1.	Tryptophan	135-138	Yvc1p	Saccharomyces cerevisiae S288C	147-151
29791245-5	2018	The accumulation of potassium and other cations in PI(3,5)P2-deficient yeast is relieved by mutations that inactivate Vnx1 or inactivate the V-ATPase and by mutations that increase the activity of a vacuolar cation export channel, Yvc1.	Potassium	20-29	Yvc1p	Saccharomyces cerevisiae S288C	231-235
29791245-5	2018	The accumulation of potassium and other cations in PI(3,5)P2-deficient yeast is relieved by mutations that inactivate Vnx1 or inactivate the V-ATPase and by mutations that increase the activity of a vacuolar cation export channel, Yvc1.	phosphatidylinositol 3,5-diphosphate	51-60	Yvc1p	Saccharomyces cerevisiae S288C	231-235
27094270-4	2016	When Ca2+ channel deletion mutants were used, it was revealed that the main contributor to the cytosolic Ca2+ pool under Cu2+ stress was the vacuolar Ca2+ channel, Yvc1, also activated by the Cch1-mediated Ca2+ influx.	cupric ion	121-125	Yvc1p	Saccharomyces cerevisiae S288C	164-168
27094270-4	2016	When Ca2+ channel deletion mutants were used, it was revealed that the main contributor to the cytosolic Ca2+ pool under Cu2+ stress was the vacuolar Ca2+ channel, Yvc1, also activated by the Cch1-mediated Ca2+ influx.	cch1	192-196	Yvc1p	Saccharomyces cerevisiae S288C	164-168
27708136-0	2016	Glutathione depletion activates the yeast vacuolar transient receptor potential channel, Yvc1p, by reversible glutathionylation of specific cysteines.	Glutathione	0-11	Yvc1p	Saccharomyces cerevisiae S288C	89-94
27708136-0	2016	Glutathione depletion activates the yeast vacuolar transient receptor potential channel, Yvc1p, by reversible glutathionylation of specific cysteines.	Cysteine	140-149	Yvc1p	Saccharomyces cerevisiae S288C	89-94
27708136-3	2016	We show here that glutathione depletion in yeast leads to the activation of two cytoplasmically inward-facing channels: the plasma membrane, Cch1p, and the vacuolar calcium channel, Yvc1p.	Glutathione	18-29	Yvc1p	Saccharomyces cerevisiae S288C	182-187
27708136-6	2016	Yvc1p has nine cysteine residues, of which eight are located in the cytoplasmic regions and one on the transmembrane domain.	Cysteine	15-23	Yvc1p	Saccharomyces cerevisiae S288C	0-5