PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33419765-4	2021	Selective inactivation of keratinocyte-specific MALT1 proteolytic activity strongly ameliorated the Card14 E138A/+- and Card14 DeltaQ136/+-induced skin disease, which was reproduced by using the imiquimod-induced mouse model.	Imiquimod	195-204	MALT1 paracaspase	Mus musculus	48-53
17095601-6	2007	Bcl10 and Malt1 cooperate with PKCs selectively for LPA-induced NF-kappaB activation but are dispensable for the activation of the Jnk, p38, Erk MAP kinase, and Akt signaling pathways.	lysophosphatidic acid	52-55	MALT1 paracaspase	Mus musculus	10-15
34926571-9	2021	MALT1 expression showed strong correlations with immune checkpoint genes, TMB, and MSI in most cancers.	1,2,4,5-tetramethoxybenzene	74-77	MALT1 paracaspase	Mus musculus	0-5
34926571-11	2021	GSEA revealed that MALT1 expression was associated with several signaling pathways, including the NF-kappaB signaling, Wnt/beta-catenin and TGF-beta signaling pathways, in PCa.	gsea	0-4	MALT1 paracaspase	Mus musculus	19-24
34753803-6	2022	Treatment of mice with mepazine, a pharmacologic MALT1 inhibitor, reduced growth of PAR1+, MDA-MB-231 xenografts and had an even more dramatic effect in reducing the burden of metastatic disease.	mepazine	23-31	MALT1 paracaspase	Mus musculus	49-54
35296093-9	2022	Moreover, inhibition of Tregs with a MALT1 inhibitor provided a therapeutic benefit, both as monotherapy and also when combined with an immune checkpoint inhibitor.	tregs	24-29	MALT1 paracaspase	Mus musculus	37-42
33539814-0	2021	Berberine induces anti-atopic dermatitis effects through the downregulation of cutaneous EIF3F and MALT1 in NC/Nga mice with atopy-like dermatitis.	Berberine	0-9	MALT1 paracaspase	Mus musculus	99-104
33539814-7	2021	In mast cells, the GeneChip  microarray showed that antigen increased the expression of EIF3F and MALT1, inhibited by berberine.	Berberine	118-127	MALT1 paracaspase	Mus musculus	98-103
33539814-10	2021	It is also suggested that the downregulation of EIF3F and MALT1 by berberine is involved in suppressing the cytokine expression.	Berberine	67-76	MALT1 paracaspase	Mus musculus	58-63
17095601-0	2007	Bcl10 and Malt1 control lysophosphatidic acid-induced NF-kappaB activation and cytokine production.	lysophosphatidic acid	24-45	MALT1 paracaspase	Mus musculus	10-15
17095601-3	2007	Here, we identify the adapter proteins Bcl10 and Malt1 as essential mediators of LPA-induced NF-kappaB activation.	lysophosphatidic acid	81-84	MALT1 paracaspase	Mus musculus	49-54
16707452-7	2006	In addition, we show that the API2-MALT1 fusion resided in the cholesterol- and sphingolipid-enriched membrane microdomains, termed lipid rafts.	Cholesterol	63-74	MALT1 paracaspase	Mus musculus	35-40
16707452-7	2006	In addition, we show that the API2-MALT1 fusion resided in the cholesterol- and sphingolipid-enriched membrane microdomains, termed lipid rafts.	Sphingolipids	80-92	MALT1 paracaspase	Mus musculus	35-40
16432253-7	2006	Thus, Bcl10 and Malt1 are essential positive mediators of FcepsilonRI-dependent mast cell activation that selectively uncouple NF-kappaB-induced proinflammatory cytokine production from degranulation and leukotriene synthesis.	Leukotrienes	204-215	MALT1 paracaspase	Mus musculus	16-21
16440738-5	2005	The apoptosis induced by doxorubicin was also inhibited by API2-MALT1, but not that induced by IL-3 withdrawal from Ba/F3.	Doxorubicin	25-36	MALT1 paracaspase	Mus musculus	64-69
34068595-7	2021	As such, LPS with Whole Glucan Particle (WGP, a representative BG) induced more severe macrophage responses than LPS alone as determined by supernatant cytokines and gene expression of downstream signals (NFkappaB, Malt-1 and Syk).	Glucans	24-30	MALT1 paracaspase	Mus musculus	215-221
31474984-8	2019	The Malt1-PDT mice have a reduced number of Tregs in the thymus and periphery, although the effect in the periphery is less pronounced compared to full-body Malt1-PD mice, indicating that also other cell types may promote Treg induction in a MALT1 protease-dependent manner.	treg	44-48	MALT1 paracaspase	Mus musculus	4-9
33092214-10	2020	This is the first report showing the therapeutic role of MALT1 inhibition in a bleomycin model of pulmonary fibrosis, thus supporting further preclinical and clinical studies.	Bleomycin	79-88	MALT1 paracaspase	Mus musculus	57-62
32450431-7	2020	Further echoing the situation in lymphocytes, LPA unbridles the protease activity of MALT1, which cleaves HOIL1 at the Arginine 165.	Arginine	119-127	MALT1 paracaspase	Mus musculus	85-90
32450431-9	2020	Lastly, we provide evidence that the guanine exchange factor GEF-H1 favors MALT1-mediated cleavage of HOIL1 and NF-kappaB signaling in this context.	Guanine	37-44	MALT1 paracaspase	Mus musculus	75-80
31595055-2	2021	Bcl10, acting as a scaffolding protein in the Carma1-Bcl10-Malt1 (CBM) complex, has a critical role in TCR-induced signaling, leading to NF-kappaB activation and is required for T-cell activation.	Receptor-CD3 Complex, Antigen, T-Cell	103-106	MALT1 paracaspase	Mus musculus	59-64
31632405-2	2019	In addition, MALT1 is a cysteine protease that further fine tunes proinflammatory signaling by cleaving specific substrates.	Cysteine	24-32	MALT1 paracaspase	Mus musculus	13-18
31129051-0	2019	Quinoline and thiazolopyridine allosteric inhibitors of MALT1.	quinoline	0-9	MALT1 paracaspase	Mus musculus	56-61
31129051-0	2019	Quinoline and thiazolopyridine allosteric inhibitors of MALT1.	Thiazolo[5,4-b]pyridine	14-30	MALT1 paracaspase	Mus musculus	56-61
31129051-1	2019	Quinolines and thiazolopyridines were developed as allosteric inhibitors of MALT1, with good cellular potency and exquisite selectivity.	Quinolines	0-10	MALT1 paracaspase	Mus musculus	76-81
31129051-1	2019	Quinolines and thiazolopyridines were developed as allosteric inhibitors of MALT1, with good cellular potency and exquisite selectivity.	thiazolopyridines	15-32	MALT1 paracaspase	Mus musculus	76-81
30158289-8	2018	Disease development was also delayed in mice treated with the MALT1 protease inhibitor mepazine and in knock-in mice expressing a catalytically inactive MALT1 mutant protein, showing an important role of MALT1 proteolytic activity.	mepazine	87-95	MALT1 paracaspase	Mus musculus	62-67
30513612-0	2018	Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function.	mepazine	0-8	MALT1 paracaspase	Mus musculus	69-74
30513612-2	2018	The phenothiazine mepazine has been shown to inhibit the proteolytic activity of MALT1 and is frequently used to study its biological role.	phenothiazine mepazine	4-26	MALT1 paracaspase	Mus musculus	81-86
30249750-2	2018	Here, we show that MI-2, a selective inhibitor of mucosa-associated lymphoid tissue lymphoma translocation-1 (MALT1), alleviated excessive inflammatory responses and was associated with restoration of healthy intestinal microbiome in mice suffering from dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	254-276	MALT1 paracaspase	Mus musculus	110-115
30249750-2	2018	Here, we show that MI-2, a selective inhibitor of mucosa-associated lymphoid tissue lymphoma translocation-1 (MALT1), alleviated excessive inflammatory responses and was associated with restoration of healthy intestinal microbiome in mice suffering from dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	278-281	MALT1 paracaspase	Mus musculus	110-115
28928392-4	2017	In this study, we found that the MALT1-targeting inhibitory small molecule, MALT1 selective inhibitor 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide (MI-2) strongly suppresses the differentiation of monocytes into osteoclasts in the absence or presence of the inflammatory cytokine tumour necrosis factor alpha.	MI 2 MALT1 inhibitor	102-197	MALT1 paracaspase	Mus musculus	33-38
29901822-0	2018	Malt1 blocks IL-1beta production by macrophages in vitro and limits dextran sodium sulfate-induced intestinal inflammation in vivo.	dextran sodium sulfate	68-90	MALT1 paracaspase	Mus musculus	0-5
29901822-6	2018	We found that Malt1 deficiency exacerbates DSS-induced colitis in mice, accompanied by higher levels of IL-1beta, and that macrophages and IL-1 signaling contribute to pathology in Malt1-/- mice.	dss	43-46	MALT1 paracaspase	Mus musculus	14-19
29901822-9	2018	Taken together, these data support the hypothesis that Malt1-/- macrophages contribute to increased susceptibility of Malt1-/- mice to DSS-induced colitis, which is dependent on IL-1 signaling.	dss	135-138	MALT1 paracaspase	Mus musculus	55-60
29901822-9	2018	Taken together, these data support the hypothesis that Malt1-/- macrophages contribute to increased susceptibility of Malt1-/- mice to DSS-induced colitis, which is dependent on IL-1 signaling.	dss	135-138	MALT1 paracaspase	Mus musculus	118-123
29367251-12	2018	Finally, treatment of wild-type mice with mepazine, a MALT1 protease inhibitor, also led to mortality upon ERA virus infection.	mepazine	42-50	MALT1 paracaspase	Mus musculus	54-59
28928392-4	2017	In this study, we found that the MALT1-targeting inhibitory small molecule, MALT1 selective inhibitor 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide (MI-2) strongly suppresses the differentiation of monocytes into osteoclasts in the absence or presence of the inflammatory cytokine tumour necrosis factor alpha.	MI 2 MALT1 inhibitor	102-197	MALT1 paracaspase	Mus musculus	76-81
28928392-4	2017	In this study, we found that the MALT1-targeting inhibitory small molecule, MALT1 selective inhibitor 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide (MI-2) strongly suppresses the differentiation of monocytes into osteoclasts in the absence or presence of the inflammatory cytokine tumour necrosis factor alpha.	MI-2	199-203	MALT1 paracaspase	Mus musculus	33-38
28928392-4	2017	In this study, we found that the MALT1-targeting inhibitory small molecule, MALT1 selective inhibitor 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide (MI-2) strongly suppresses the differentiation of monocytes into osteoclasts in the absence or presence of the inflammatory cytokine tumour necrosis factor alpha.	MI-2	199-203	MALT1 paracaspase	Mus musculus	76-81
27105502-4	2016	In the present study, we examined the pharmacological effect of two specific MALT1 inhibitors MI-2 and mepazine on the dextran sulfate sodium (DSS)-induced experimental colitis in mice, followed by mechanistic analysis on NF-kappaB and NLRP3 inflammasome activation.	Dextran Sulfate	119-141	MALT1 paracaspase	Mus musculus	77-82
27105502-0	2016	MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-kappaB and NLRP3 inflammasome activation.	Dextran Sulfate	44-47	MALT1 paracaspase	Mus musculus	0-5
27105502-4	2016	In the present study, we examined the pharmacological effect of two specific MALT1 inhibitors MI-2 and mepazine on the dextran sulfate sodium (DSS)-induced experimental colitis in mice, followed by mechanistic analysis on NF-kappaB and NLRP3 inflammasome activation.	Dextran Sulfate	143-146	MALT1 paracaspase	Mus musculus	77-82
27105502-4	2016	In the present study, we examined the pharmacological effect of two specific MALT1 inhibitors MI-2 and mepazine on the dextran sulfate sodium (DSS)-induced experimental colitis in mice, followed by mechanistic analysis on NF-kappaB and NLRP3 inflammasome activation.	mepazine	103-111	MALT1 paracaspase	Mus musculus	77-82
27105502-6	2016	Moreover, protein and mRNA levels of DSS-induced proinflammatory cytokines in colon, including TNF, IL-1beta, IL-6, IL-18, IL-17A and IFN-gamma, were markedly suppressed by MALT1 inhibitors.	Dextran Sulfate	37-40	MALT1 paracaspase	Mus musculus	173-178
27105502-7	2016	The underlying mechanisms for the protective effect of MALT1 inhibitors in DSS-induced colitis may be attributed to its inhibition on NF-kappaB and NLRP3 inflammasome activation in macrophages.	Dextran Sulfate	75-78	MALT1 paracaspase	Mus musculus	55-60
25202022-0	2014	C-type lectin receptor dectin-3 mediates trehalose 6,6"-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-kappaB activation.	Trehalose	41-50	MALT1 paracaspase	Mus musculus	119-124
25202022-0	2014	C-type lectin receptor dectin-3 mediates trehalose 6,6"-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-kappaB activation.	6,6"-dimycolate	51-66	MALT1 paracaspase	Mus musculus	119-124
22708078-5	2012	Uptake of palmitate, metabolism to diacylglycerol, and subsequent activation of protein kinase C (PKC) appear to mechanistically link palmitate with Bcl10, known as a central component of a signaling complex that, along with CARMA3 and MALT1, activates NF-kB downstream of selected cell surface receptors.	Palmitates	10-19	MALT1 paracaspase	Mus musculus	236-241
22708078-5	2012	Uptake of palmitate, metabolism to diacylglycerol, and subsequent activation of protein kinase C (PKC) appear to mechanistically link palmitate with Bcl10, known as a central component of a signaling complex that, along with CARMA3 and MALT1, activates NF-kB downstream of selected cell surface receptors.	Palmitates	134-143	MALT1 paracaspase	Mus musculus	236-241
25043939-8	2014	Importantly, while complete absence of MALT1 affects the differentiation of regulatory T (Treg) cells in vivo, the MALT1 protease inhibitor mepazine did not affect Treg development.	mepazine	140-148	MALT1 paracaspase	Mus musculus	115-120
24792914-5	2014	We have further shown that TCR-stimulated glutamine uptake and mTORC1 activation also required a TCR signaling complex composed of the scaffold protein CARMA1, the adaptor molecule BCL10, and the paracaspase MALT1.	Glutamine	42-51	MALT1 paracaspase	Mus musculus	208-213