PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
11162890-1	2000	The present study utilizes in situ molecular hybridization and immunocytochemistry to investigate the follicular localization and expression of four thematically related sterol-metabolizing genes; low-density lipoprotein (LDL) receptor, steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage (CYP11A) enzyme, and cytochrome P450 17alpha-hydroxylase/C(17-20) lyase (CYP17).	Sterols	170-176	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	341-391
16341769-3	2005	Cytochrome P450-c17 (CYP17) interacts with cytochrome b5 in the biosynthesis of the 16-androstene steroids and the sex steroids from pregnenolone.	16-androstene steroids	84-106	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	0-19
16341769-3	2005	Cytochrome P450-c17 (CYP17) interacts with cytochrome b5 in the biosynthesis of the 16-androstene steroids and the sex steroids from pregnenolone.	16-androstene steroids	84-106	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	21-26
16341769-3	2005	Cytochrome P450-c17 (CYP17) interacts with cytochrome b5 in the biosynthesis of the 16-androstene steroids and the sex steroids from pregnenolone.	Steroids	98-106	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	0-19
16341769-3	2005	Cytochrome P450-c17 (CYP17) interacts with cytochrome b5 in the biosynthesis of the 16-androstene steroids and the sex steroids from pregnenolone.	Steroids	98-106	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	21-26
16341769-3	2005	Cytochrome P450-c17 (CYP17) interacts with cytochrome b5 in the biosynthesis of the 16-androstene steroids and the sex steroids from pregnenolone.	Pregnenolone	133-145	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	0-19
16341769-3	2005	Cytochrome P450-c17 (CYP17) interacts with cytochrome b5 in the biosynthesis of the 16-androstene steroids and the sex steroids from pregnenolone.	Pregnenolone	133-145	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	21-26
16341769-4	2005	Amino acid substitutions in CYP17 could therefore affect the ability of this enzyme to catalyze the reactions leading to the production of androstenone and the sex steroids.	androst-16-en-3-one	139-151	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	28-33
16341769-4	2005	Amino acid substitutions in CYP17 could therefore affect the ability of this enzyme to catalyze the reactions leading to the production of androstenone and the sex steroids.	Steroids	164-172	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	28-33
15001547-0	2004	Requirement for proximal putative Sp1 and AP-2 cis-deoxyribonucleic acid elements in mediating basal and luteinizing hormone- and insulin-dependent in vitro transcriptional activation of the CYP17 gene in porcine theca cells.	cis-deoxyribonucleic acid	47-72	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	191-196
15001547-10	2004	Point mutation of the proximal Sp1-like element in full-length -976/+31 CYP17/luc impaired basal transcription minimally (by 21%; P = NS) and stimulation by LH (76%), insulin (67%), and combined peptides (54%) significantly (each P < 0.05 vs. wild type).	Luteinizing Hormone	157-159	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	72-77
15001547-14	2004	At the level of second messenger signaling, insulin did not potentiate LH-enhanced cAMP accumulation, whereas a stable cAMP analog mimicked LH action and augmented insulin"s stimulation of full-length and deletional fragments of CYP17/luc.	Cyclic AMP	119-123	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	229-234
11162890-1	2000	The present study utilizes in situ molecular hybridization and immunocytochemistry to investigate the follicular localization and expression of four thematically related sterol-metabolizing genes; low-density lipoprotein (LDL) receptor, steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage (CYP11A) enzyme, and cytochrome P450 17alpha-hydroxylase/C(17-20) lyase (CYP17).	Sterols	170-176	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	393-398
11162890-10	2000	Follicular fluid concentrations of androstenedione, and progesterone in contralateral ovaries correlated strongly and positively with accumulation of CYP17, and CYP11A proteins.	Androstenedione	35-50	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	150-155
11162890-10	2000	Follicular fluid concentrations of androstenedione, and progesterone in contralateral ovaries correlated strongly and positively with accumulation of CYP17, and CYP11A proteins.	Progesterone	56-68	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	150-155
8117675-2	1994	CYP17 catalyzes the cleavage of the C-17 side chain of progesterone to form androstenedione.	Progesterone	55-67	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	0-5
8117675-2	1994	CYP17 catalyzes the cleavage of the C-17 side chain of progesterone to form androstenedione.	Androstenedione	76-91	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	0-5
8117675-9	1994	Accordingly, CYP17 is proposed to catalyze oxidations via both oxene and peroxide chemistry.	oxirene	63-68	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	13-18
8117675-9	1994	Accordingly, CYP17 is proposed to catalyze oxidations via both oxene and peroxide chemistry.	Peroxides	73-81	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	13-18
35219259-7	2022	In addition, Cd exposure decreased mRNA expression of STAR, CYP11A1, 3beta-HSD, CYP17A1, and 17beta-HSD of testis and the concentrations of T and thyroid-stimulating hormone (TSH).	Cadmium	13-15	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	80-87
27285831-5	2016	Only transcriptional levels of CYP17, CYP11A1, CYP19A, SRD5A1, and AKR1C-pig6 were correlated with the fat concentration of androstenone (0.57 < r < 0.70, P < 0.05) confirming that the amount of androstenone stored in fat is related to the production in testes of androstenone and more generally to all sex steroids.	androst-16-en-3-one	204-216	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	31-36
27285831-5	2016	Only transcriptional levels of CYP17, CYP11A1, CYP19A, SRD5A1, and AKR1C-pig6 were correlated with the fat concentration of androstenone (0.57 < r < 0.70, P < 0.05) confirming that the amount of androstenone stored in fat is related to the production in testes of androstenone and more generally to all sex steroids.	androst-16-en-3-one	204-216	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	31-36
27285831-5	2016	Only transcriptional levels of CYP17, CYP11A1, CYP19A, SRD5A1, and AKR1C-pig6 were correlated with the fat concentration of androstenone (0.57 < r < 0.70, P < 0.05) confirming that the amount of androstenone stored in fat is related to the production in testes of androstenone and more generally to all sex steroids.	Steroids	316-324	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	31-36
24681211-4	2014	Rosiglitazone decreased A4 and T secretion by reducing the expression and activity of CYP17 and 17betaHSD and did not change estradiol secretion and CYP19.	Rosiglitazone	0-13	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	86-91
20043997-9	2010	Although the Leu105Ala mutation of both baboon and pig CYP17 exhibited the same trend regarding the ratios, the rate of progesterone conversion was reduced.	Progesterone	120-132	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	55-60
9166694-12	1997	Staining intensities of P450arom, P450c17, and 3betaHSD were correlated with each other and with follicular fluid concentrations of the steroids estradiol, androstenedione, and progesterone, whose production they catalyzed.	Steroids	136-144	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	34-41
9166694-12	1997	Staining intensities of P450arom, P450c17, and 3betaHSD were correlated with each other and with follicular fluid concentrations of the steroids estradiol, androstenedione, and progesterone, whose production they catalyzed.	Estradiol	145-154	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	34-41
9166694-12	1997	Staining intensities of P450arom, P450c17, and 3betaHSD were correlated with each other and with follicular fluid concentrations of the steroids estradiol, androstenedione, and progesterone, whose production they catalyzed.	Androstenedione	156-171	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	34-41
8948449-1	1995	Using NADPH-cytochrome P-450 reductase as electron donor the homogeneous pig 17 alpha-hydroxylase-17,20-lyase (CYP17) was shown to catalyse the conversion of delta 5, as well as delta 4, steroids (pregnenolone and progesterone respectively) predominantly into the corresponding 17 alpha-hydroxylated products.	Steroids	187-195	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	111-116
8948449-1	1995	Using NADPH-cytochrome P-450 reductase as electron donor the homogeneous pig 17 alpha-hydroxylase-17,20-lyase (CYP17) was shown to catalyse the conversion of delta 5, as well as delta 4, steroids (pregnenolone and progesterone respectively) predominantly into the corresponding 17 alpha-hydroxylated products.	Pregnenolone	197-209	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	111-116
8948449-1	1995	Using NADPH-cytochrome P-450 reductase as electron donor the homogeneous pig 17 alpha-hydroxylase-17,20-lyase (CYP17) was shown to catalyse the conversion of delta 5, as well as delta 4, steroids (pregnenolone and progesterone respectively) predominantly into the corresponding 17 alpha-hydroxylated products.	Progesterone	214-226	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	111-116
8948449-12	1995	Like the pig CYP17, the human CYP17 also catalysed the cytochrome b5-dependent direct cleavage of pregnenolone into the delta 5,16-steroid, but unlike it the human enzyme did not cleave progesterone at all.	Pregnenolone	98-110	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	13-18
8948449-12	1995	Like the pig CYP17, the human CYP17 also catalysed the cytochrome b5-dependent direct cleavage of pregnenolone into the delta 5,16-steroid, but unlike it the human enzyme did not cleave progesterone at all.	delta 5,16-steroid	120-138	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	13-18
27285831-5	2016	Only transcriptional levels of CYP17, CYP11A1, CYP19A, SRD5A1, and AKR1C-pig6 were correlated with the fat concentration of androstenone (0.57 < r < 0.70, P < 0.05) confirming that the amount of androstenone stored in fat is related to the production in testes of androstenone and more generally to all sex steroids.	androst-16-en-3-one	124-136	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	31-36
23000191-10	2013	These results indicate that transactivation of these nuclear receptors may lead to increased levels of 16-androstene steroids, likely by altering the activity of CYP17A1 through CYB5A and CYB5R1 to the andien-beta synthase reaction and away from the 17alpha-hydroxylase and C17, 20 lyase reactions.	16-androstene steroids	103-125	cytochrome P450 family 17 subfamily A member 1	Sus scrofa	162-169