PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
11910006-4	2002	Expression studies using the auxin-inducible reporter IAA2::uidA revealed that AUX1 facilitates IAA loading into the leaf vascular transport system.	indoleacetic acid	54-57	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	79-83
11910006-6	2002	Exogenous application of the synthetic auxin 1-naphthylacetic acid is able to rescue the aux1 lateral root phenotype, implying that root auxin levels are suboptimal for lateral root primordium initiation in the mutant.	1-naphthaleneacetic acid	45-66	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	89-93
12148533-12	2002	The auxin-resistant mutants axrl, axr4 and aux1 all showed the wild-type lateral root elongation responses to a nitrate-rich patch, suggesting that auxin is not required for this response.	Nitrates	112-119	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	43-47
11864575-8	2002	Similar to aux1 mutants, the vesicle trafficking inhibitor brefeldin A (BFA) interferes with polar hair initiation, and AUX1 function is required for BFA-mediated polarity changes.	Brefeldin A	150-153	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	120-124
11864575-9	2002	Consistently, BFA inhibits membrane trafficking of AUX1, trichoblast hyperpolarization induced by 2,4-D, and alters the distal auxin maximum.	Brefeldin A	14-17	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	51-55
11864575-10	2002	Our results identify AUX1 as one component of a novel BFA-sensitive auxin transport pathway polarizing cells toward a hormone maximum.	Brefeldin A	54-57	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	21-25
11641271-4	2001	Localization of the auxin permease AUX1 in the Arabidopsis root apex has revealed a novel phloem-based IAA transport pathway.	indoleacetic acid	103-106	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	35-39
11910006-0	2002	AUX1 promotes lateral root formation by facilitating indole-3-acetic acid distribution between sink and source tissues in the Arabidopsis seedling.	indoleacetic acid	53-73	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	0-4
11910006-2	2002	We report that mutations in the putative auxin influx carrier AUX1 modify root architecture as a result of the disruption in hormone transport between indole-3-acetic acid (IAA) source and sink tissues.	indoleacetic acid	151-171	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	62-66
11910006-2	2002	We report that mutations in the putative auxin influx carrier AUX1 modify root architecture as a result of the disruption in hormone transport between indole-3-acetic acid (IAA) source and sink tissues.	indoleacetic acid	173-176	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	62-66
11910006-3	2002	Gas chromatography-selected reaction monitoring-mass spectrometry measurements revealed that the aux1 mutant exhibited altered IAA distribution in young leaf and root tissues, the major IAA source and sink organs, respectively, in the developing seedling.	indoleacetic acid	127-130	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	97-101
11641271-5	2001	AUX1, asymmetrically localized to the plasma membrane of root protophloem cells, is proposed to promote the acropetal, post-phloem movement of auxin to the root apex.	acropetal	108-117	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	0-4
11161055-1	2001	We have found that chromosaponin I (CSI), a gamma-pyronyl-triterpenoid saponin isolated from pea (Pisum sativum L. cv Alaska), specifically interacts with AUX1 protein in regulating the gravitropic response of Arabidopsis roots.	gamma-pyronyl-triterpenoid	44-70	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	155-159
11161055-1	2001	We have found that chromosaponin I (CSI), a gamma-pyronyl-triterpenoid saponin isolated from pea (Pisum sativum L. cv Alaska), specifically interacts with AUX1 protein in regulating the gravitropic response of Arabidopsis roots.	Saponins	25-32	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	155-159
11161055-5	2001	In aux1-7 roots, CSI stimulated the uptake of [(3)H]indole-3-acetic acid (IAA) and induced gravitropic bending.	chromosaponin I	17-20	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	3-7
10205161-0	1999	AUX1 regulates root gravitropism in Arabidopsis by facilitating auxin uptake within root apical tissues.	Indoleacetic Acids	64-69	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	0-4
10205161-3	1999	We are able to bypass the defect within auxin uptake and restore the gravitropic root phenotype of aux1 by growing mutant seedlings in the presence of the membrane-permeable synthetic auxin, 1-naphthaleneacetic acid.	1-naphthaleneacetic acid	191-215	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	99-103
34273207-4	2021	Our results showed that PIN-FORMED (PIN) proteins such as PIN1, PIN3, PIN4 and PIN7, and AUX1/LAX proteins such as AUX1, LAX1 and LAX2 were all ectopically up-regulated in the root-apex TZ in response to Al stress, and co-ordinately regulate the local auxin accumulation in the TZ and root growth inhibition.	Thiazoles	186-188	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	89-93
34758285-7	2022	Thus, KAI2 signaling is increased by phosphate starvation to trigger an ethylene- AUX1/PIN2-auxin cascade required for RH elongation.	Phosphates	37-46	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	82-86
34758285-7	2022	Thus, KAI2 signaling is increased by phosphate starvation to trigger an ethylene- AUX1/PIN2-auxin cascade required for RH elongation.	ethylene	72-80	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	82-86
9761792-3	1998	Expression of the BA-GUS gene in the axr1, axr4, and aux1 mutants required 10- to 100-fold higher auxin concentration than that in the wild-type background.	Barium	18-20	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	53-57
9697346-0	1998	Differential effects of 1-naphthaleneacetic acid, indole-3-acetic acid and 2,4-dichlorophenoxyacetic acid on the gravitropic response of roots in an auxin-resistant mutant of arabidopsis, aux1.	2,4-Dichlorophenoxyacetic Acid	75-105	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	188-192
9697346-1	1998	The agravitropic nature of root growth of an auxin-resistant mutant of Arabidopsis, aux1, was restored when the synthetic auxin 1-naphthaleneacetic acid (NAA) was added to the growth medium; aux1 roots were not resistant to NAA.	1-naphthaleneacetic acid	128-152	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	84-88
9697346-1	1998	The agravitropic nature of root growth of an auxin-resistant mutant of Arabidopsis, aux1, was restored when the synthetic auxin 1-naphthaleneacetic acid (NAA) was added to the growth medium; aux1 roots were not resistant to NAA.	1-naphthaleneacetic acid	154-157	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	84-88
9697346-1	1998	The agravitropic nature of root growth of an auxin-resistant mutant of Arabidopsis, aux1, was restored when the synthetic auxin 1-naphthaleneacetic acid (NAA) was added to the growth medium; aux1 roots were not resistant to NAA.	1-naphthaleneacetic acid	154-157	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	191-195
9697346-1	1998	The agravitropic nature of root growth of an auxin-resistant mutant of Arabidopsis, aux1, was restored when the synthetic auxin 1-naphthaleneacetic acid (NAA) was added to the growth medium; aux1 roots were not resistant to NAA.	1-naphthaleneacetic acid	224-227	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	84-88
8688077-4	1996	Indole-3-acetic acid, the major form of auxin in higher plants, is structurally similar to tryptophan and is a likely substrate for the AUX1 gene product.	indoleacetic acid	0-20	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	136-140
8688077-4	1996	Indole-3-acetic acid, the major form of auxin in higher plants, is structurally similar to tryptophan and is a likely substrate for the AUX1 gene product.	Tryptophan	91-101	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	136-140
7768447-12	1995	The EIR1, AUX1 and HLS1 genes may function in the interactions between ethylene and other plant hormones that occur late in the signaling pathway of this simple gas.	ethylene	71-79	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	10-14
16667854-0	1990	The aux1 Mutation of Arabidopsis Confers Both Auxin and Ethylene Resistance.	Indoleacetic Acids	46-51	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	4-8
16667854-0	1990	The aux1 Mutation of Arabidopsis Confers Both Auxin and Ethylene Resistance.	ethylene	56-64	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	4-8
16667854-6	1990	The sensitivity of wild-type and aux1-7 roots to indole-3-acetic acid, 2,4-dichlorophenoxyacetic acid, and ethylene was determined.	indoleacetic acid	49-69	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	33-37
16667854-6	1990	The sensitivity of wild-type and aux1-7 roots to indole-3-acetic acid, 2,4-dichlorophenoxyacetic acid, and ethylene was determined.	2,4-Dichlorophenoxyacetic Acid	71-101	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	33-37
16667854-6	1990	The sensitivity of wild-type and aux1-7 roots to indole-3-acetic acid, 2,4-dichlorophenoxyacetic acid, and ethylene was determined.	ethylene	107-115	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	33-37
16667854-7	1990	The results of these assays show that aux1-7 plants require a 12-fold (indole-3-acetic acid) or 18-fold (2,4-dichlorophenoxyacetic acid) higher concentration of auxin than wild-type for a 50% inhibition of root growth.	indoleacetic acid	71-91	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	38-44
16667854-7	1990	The results of these assays show that aux1-7 plants require a 12-fold (indole-3-acetic acid) or 18-fold (2,4-dichlorophenoxyacetic acid) higher concentration of auxin than wild-type for a 50% inhibition of root growth.	2,4-Dichlorophenoxyacetic Acid	105-135	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	38-44
16667854-8	1990	In addition, ethylene inhibition of root growth in aux1-7 plants is approximately 30% that of wild-type at saturating ethylene concentrations.	ethylene	13-21	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	51-55
16667854-8	1990	In addition, ethylene inhibition of root growth in aux1-7 plants is approximately 30% that of wild-type at saturating ethylene concentrations.	ethylene	118-126	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	51-55
16667854-9	1990	These results indicate that aux1 plants are resistant to both auxin and ethylene.	Indoleacetic Acids	62-67	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	28-32
16667854-9	1990	These results indicate that aux1 plants are resistant to both auxin and ethylene.	ethylene	72-80	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	28-32
16667854-10	1990	We have also determined the effect of ethylene treatment on chlorophyll loss and peroxidase activity in the leaves of aux1 and wild-type plants.	ethylene	38-46	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	118-122
34273207-4	2021	Our results showed that PIN-FORMED (PIN) proteins such as PIN1, PIN3, PIN4 and PIN7, and AUX1/LAX proteins such as AUX1, LAX1 and LAX2 were all ectopically up-regulated in the root-apex TZ in response to Al stress, and co-ordinately regulate the local auxin accumulation in the TZ and root growth inhibition.	Thiazoles	186-188	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	115-119
34273207-4	2021	Our results showed that PIN-FORMED (PIN) proteins such as PIN1, PIN3, PIN4 and PIN7, and AUX1/LAX proteins such as AUX1, LAX1 and LAX2 were all ectopically up-regulated in the root-apex TZ in response to Al stress, and co-ordinately regulate the local auxin accumulation in the TZ and root growth inhibition.	Aluminum	204-206	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	89-93
34273207-4	2021	Our results showed that PIN-FORMED (PIN) proteins such as PIN1, PIN3, PIN4 and PIN7, and AUX1/LAX proteins such as AUX1, LAX1 and LAX2 were all ectopically up-regulated in the root-apex TZ in response to Al stress, and co-ordinately regulate the local auxin accumulation in the TZ and root growth inhibition.	Aluminum	204-206	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	115-119
34273207-4	2021	Our results showed that PIN-FORMED (PIN) proteins such as PIN1, PIN3, PIN4 and PIN7, and AUX1/LAX proteins such as AUX1, LAX1 and LAX2 were all ectopically up-regulated in the root-apex TZ in response to Al stress, and co-ordinately regulate the local auxin accumulation in the TZ and root growth inhibition.	Indoleacetic Acids	252-257	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	89-93
34273207-4	2021	Our results showed that PIN-FORMED (PIN) proteins such as PIN1, PIN3, PIN4 and PIN7, and AUX1/LAX proteins such as AUX1, LAX1 and LAX2 were all ectopically up-regulated in the root-apex TZ in response to Al stress, and co-ordinately regulate the local auxin accumulation in the TZ and root growth inhibition.	Indoleacetic Acids	252-257	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	115-119
34273207-4	2021	Our results showed that PIN-FORMED (PIN) proteins such as PIN1, PIN3, PIN4 and PIN7, and AUX1/LAX proteins such as AUX1, LAX1 and LAX2 were all ectopically up-regulated in the root-apex TZ in response to Al stress, and co-ordinately regulate the local auxin accumulation in the TZ and root growth inhibition.	Thiazoles	278-280	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	89-93
34273207-4	2021	Our results showed that PIN-FORMED (PIN) proteins such as PIN1, PIN3, PIN4 and PIN7, and AUX1/LAX proteins such as AUX1, LAX1 and LAX2 were all ectopically up-regulated in the root-apex TZ in response to Al stress, and co-ordinately regulate the local auxin accumulation in the TZ and root growth inhibition.	Thiazoles	278-280	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	115-119
33673672-5	2021	The involvement of ethylene/auxin crosstalk in the salt stress response was evaluated by introducing auxin reporters for local biosynthesis (pTAR2::GUS) and polar transport (pLAX3::GUS, pAUX1::AUX1-YFP, pPIN1::PIN1-GFP, pPIN2::PIN2-GFP, pPIN3::GUS) in the mutants.	Salts	51-55	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	187-191
31436880-0	2019	The RING finger E3 ligases PIR1 and PIR2 mediate PP2CA degradation to enhance abscisic acid response in Arabidopsis.	Abscisic Acid	78-91	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	27-31
32905588-5	2020	We found that the gravitropism-deficient mutant aux1 showed enhanced hydrotropism in the oblique orientation but impaired root elongation towards the water in a vertical orientation.	Water	150-155	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	48-52
32905588-9	2020	Additionally, gravity facilitated roots" search for vertically-oriented water, because the miz1/aux1 double-mutant showed attenuated root elongation towards the water in a vertical orientation, in contrast to miz1.	Water	72-77	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	96-100
32905588-9	2020	Additionally, gravity facilitated roots" search for vertically-oriented water, because the miz1/aux1 double-mutant showed attenuated root elongation towards the water in a vertical orientation, in contrast to miz1.	Water	161-166	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	96-100
32662721-9	2020	Expression of auxin-responsive AUX1 and GH3 genes was significantly reduced in abi3-6 cells, indicating that auxin levels or distribution may be altered in absence of ABI3.	Indoleacetic Acids	14-19	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	31-35
32662721-9	2020	Expression of auxin-responsive AUX1 and GH3 genes was significantly reduced in abi3-6 cells, indicating that auxin levels or distribution may be altered in absence of ABI3.	Indoleacetic Acids	109-114	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	31-35
32582237-0	2020	NRT1.1-Mediated Nitrate Suppression of Root Coiling Relies on PIN2- and AUX1-Mediated Auxin Transport.	Nitrates	16-23	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	72-76
32582237-6	2020	Nitrate deficiency caused root coiling on horizontal plates, which is inhibited by an auxin transport inhibitor, and by mutations in PIN-FORMED2 (PIN2) and AUXIN RESISTANT 1 (AUX1).	Nitrates	0-7	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	156-173
32582237-6	2020	Nitrate deficiency caused root coiling on horizontal plates, which is inhibited by an auxin transport inhibitor, and by mutations in PIN-FORMED2 (PIN2) and AUXIN RESISTANT 1 (AUX1).	Nitrates	0-7	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	175-179
32582237-8	2020	In addition, PIN2- and AUX1-mediated auxin transports are epistatic to NRT1.1 in nitrate deficiency-induced ARG.	Nitrates	81-88	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	23-27
31436880-5	2019	The PIR1.2 exhibited E3 ligase activity and determined PP2CA stability in the presence of ABA.	Abscisic Acid	90-93	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	4-8
31436880-6	2019	Consistent with the conclusion that PIR1 promotes ABA signaling by removing PP2CA, a negative modulator, the pir1 knockout mutant displayed an ABA-hyposensitive phenotype.	Abscisic Acid	50-53	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	36-40
31436880-6	2019	Consistent with the conclusion that PIR1 promotes ABA signaling by removing PP2CA, a negative modulator, the pir1 knockout mutant displayed an ABA-hyposensitive phenotype.	Abscisic Acid	50-53	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	109-113
31436880-6	2019	Consistent with the conclusion that PIR1 promotes ABA signaling by removing PP2CA, a negative modulator, the pir1 knockout mutant displayed an ABA-hyposensitive phenotype.	Abscisic Acid	143-146	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	36-40
31436880-6	2019	Consistent with the conclusion that PIR1 promotes ABA signaling by removing PP2CA, a negative modulator, the pir1 knockout mutant displayed an ABA-hyposensitive phenotype.	Abscisic Acid	143-146	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	109-113
31436880-9	2019	Using a cell-free degradation assay, ABA promoted degradation of PP2CA, however, such degradation was delayed when incubated with protein extract prepared from the pir1-1/pir2 double mutant.	Abscisic Acid	37-40	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	164-170
31436880-10	2019	Our data suggest that PIR1 and PIR2 positively modulate ABA signaling by targeting PP2CA for degradation.	Abscisic Acid	56-59	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	22-26
31053903-0	2019	Potassium Stimulation of IAA Transport Mediated by the Arabidopsis Importer AUX1 Investigated in a Heterologous Yeast System.	Potassium	0-9	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	76-80
31184154-4	2019	NUE of B. napus increased under LN, which enhanced N uptake ability by regulating root system architecture and plasma membrane H+-ATPase activity; AUX1 was involved in this process.	Nitrogen	0-1	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	147-151
29893960-5	2018	An increase in auxin level in the root tips was associated with increased expression of auxin biosynthesis genes and auxin polar transporter AUX1 and PIN2 genes under BA stress.	Benzoic Acid	167-169	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	141-145
29893960-6	2018	Mutant analyses demonstrated that AUX1 and PIN2 rather than PIN1 were required for the inhibition of primary root elongation during BA exposure.	Benzoic Acid	132-134	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	34-38
29893960-7	2018	Furthermore, BA stimulated ethylene evolution, whereas blocking BA-induced ethylene signaling with an ethylene biosynthesis inhibitor (Co2+), an ethylene perception antagonist (1-methylcyclopropene) or ethylene signaling mutant lines etr1-3 and ein3eil1 compromised BA-mediated inhibition of root elongation and up-regulation of auxin biosynthesis-related genes together with AUX1 and PIN2, indicating that ethylene signal was involved in auxin-mediated inhibition of primary root elongation during BA stress.	Benzoic Acid	64-66	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	376-380
29893960-7	2018	Furthermore, BA stimulated ethylene evolution, whereas blocking BA-induced ethylene signaling with an ethylene biosynthesis inhibitor (Co2+), an ethylene perception antagonist (1-methylcyclopropene) or ethylene signaling mutant lines etr1-3 and ein3eil1 compromised BA-mediated inhibition of root elongation and up-regulation of auxin biosynthesis-related genes together with AUX1 and PIN2, indicating that ethylene signal was involved in auxin-mediated inhibition of primary root elongation during BA stress.	Benzoic Acid	64-66	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	376-380
29893960-7	2018	Furthermore, BA stimulated ethylene evolution, whereas blocking BA-induced ethylene signaling with an ethylene biosynthesis inhibitor (Co2+), an ethylene perception antagonist (1-methylcyclopropene) or ethylene signaling mutant lines etr1-3 and ein3eil1 compromised BA-mediated inhibition of root elongation and up-regulation of auxin biosynthesis-related genes together with AUX1 and PIN2, indicating that ethylene signal was involved in auxin-mediated inhibition of primary root elongation during BA stress.	Benzoic Acid	64-66	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	376-380
29563504-6	2018	AUX1-mediated IAA transport, as well as IAA- triggered calcium signals, are blocked by treatment with the SCFTIR1/AFB - inhibitor auxinole.	alpha-(2,4-dimethylphenylethyl-2-oxo)indole-3-acetic acid	130-138	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	0-4
29893960-9	2018	Taken together, our results reveal that the allelochemical BA inhibits root elongation by increasing auxin accumulation via stimulation of auxin biosynthesis and AUX1/PIN2-mediated auxin transport via stimulation of ethylene production and an auxin/ethylene-independent ROS burst.	Benzoic Acid	59-61	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	162-166
29893960-9	2018	Taken together, our results reveal that the allelochemical BA inhibits root elongation by increasing auxin accumulation via stimulation of auxin biosynthesis and AUX1/PIN2-mediated auxin transport via stimulation of ethylene production and an auxin/ethylene-independent ROS burst.	ethylene	216-224	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	162-166
29893960-9	2018	Taken together, our results reveal that the allelochemical BA inhibits root elongation by increasing auxin accumulation via stimulation of auxin biosynthesis and AUX1/PIN2-mediated auxin transport via stimulation of ethylene production and an auxin/ethylene-independent ROS burst.	ethylene	249-257	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	162-166
29893960-9	2018	Taken together, our results reveal that the allelochemical BA inhibits root elongation by increasing auxin accumulation via stimulation of auxin biosynthesis and AUX1/PIN2-mediated auxin transport via stimulation of ethylene production and an auxin/ethylene-independent ROS burst.	Reactive Oxygen Species	270-273	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	162-166
29669031-2	2018	With Mg deficiency, both ethylene and NO promoted the elevation of root auxin levels in roots by inducing the expression of AUXIN-RESISTANT1 (AUX1), PIN-FORMED 1 (PIN1) and PIN2 transporters.	ethylene	25-33	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	124-140
29669031-2	2018	With Mg deficiency, both ethylene and NO promoted the elevation of root auxin levels in roots by inducing the expression of AUXIN-RESISTANT1 (AUX1), PIN-FORMED 1 (PIN1) and PIN2 transporters.	ethylene	25-33	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	142-146
29499078-0	2018	Ethylene mediates dichromate-induced inhibition of primary root growth by altering AUX1 expression and auxin accumulation in Arabidopsis thaliana.	ethylene	0-8	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	83-87
29499078-0	2018	Ethylene mediates dichromate-induced inhibition of primary root growth by altering AUX1 expression and auxin accumulation in Arabidopsis thaliana.	Dichromate	18-28	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	83-87
29499078-7	2018	In addition, genetic and physiological investigations show that AUXIN-RESISTANT1 (AUX1) participates in Cr(VI)-induced inhibition of primary root growth.	Chromium	104-106	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	64-80
29499078-7	2018	In addition, genetic and physiological investigations show that AUXIN-RESISTANT1 (AUX1) participates in Cr(VI)-induced inhibition of primary root growth.	Chromium	104-106	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	82-86
29499078-8	2018	Taken together, our results indicate that ethylene mediates Cr(VI)-induced inhibition of primary root elongation by increasing auxin accumulation and polar transport by stimulating the expression of AUX1.	ethylene	42-50	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	199-203
29499078-8	2018	Taken together, our results indicate that ethylene mediates Cr(VI)-induced inhibition of primary root elongation by increasing auxin accumulation and polar transport by stimulating the expression of AUX1.	chromium hexavalent ion	60-66	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	199-203
28780645-3	2017	An analysis of primary root growth of WT, med12, aux1-7 and med12 aux1 single and double mutants in response to sucrose and/or N-1-naphthylphthalamic acid (NPA) placed MED12 upstream of auxin transport for the sugar modulation of root growth.	Sucrose	112-119	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	49-53
28780645-3	2017	An analysis of primary root growth of WT, med12, aux1-7 and med12 aux1 single and double mutants in response to sucrose and/or N-1-naphthylphthalamic acid (NPA) placed MED12 upstream of auxin transport for the sugar modulation of root growth.	alpha-naphthylphthalamic acid	127-154	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	49-55
28780645-3	2017	An analysis of primary root growth of WT, med12, aux1-7 and med12 aux1 single and double mutants in response to sucrose and/or N-1-naphthylphthalamic acid (NPA) placed MED12 upstream of auxin transport for the sugar modulation of root growth.	alpha-naphthylphthalamic acid	127-154	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	49-53
28780645-9	2017	The growth response of primary roots of WT, med12, aux1-7 and med12 aux1 single and double mutants to sucrose and application of auxin transport inhibitor N-1-naphthylphthalamic acid (NPA) revealed the correlation of med12 phenotype with the activity of the auxin intake permease and suggests that MED12 acts upstream of AUX1 in the root growth response to sugar.	Sucrose	102-109	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	321-325
28890725-6	2017	Thus it appears that the stimulatory effect seen at low ABA concentrations is via an ethylene-independent pathway requiring auxin signalling and auxin efflux through PIN2/EIR1, while the inhibitory effect at high ABA concentrations is via an ethylene-dependent pathway requiring auxin signalling and auxin influx through AUX1.	Abscisic Acid	56-59	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	321-325
28698357-2	2017	Here, we show that Arabidopsis (Arabidopsis thaliana) RopGEF1, a guanine nucleotide exchange factor and activator of Rho GTPases of plants (ROPs), is critically involved in polar distribution of auxin influx carrier AUX1 and differential accumulation of efflux carriers PIN7 and PIN2 and is important for embryo and early seedling development when RopGEF1 is prevalently expressed.	Guanine Nucleotides	65-83	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	216-220
28890725-6	2017	Thus it appears that the stimulatory effect seen at low ABA concentrations is via an ethylene-independent pathway requiring auxin signalling and auxin efflux through PIN2/EIR1, while the inhibitory effect at high ABA concentrations is via an ethylene-dependent pathway requiring auxin signalling and auxin influx through AUX1.	ethylene	85-93	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	321-325
27831474-7	2016	The ethylene effect was independent of auxin-signaling by TIR1-AFB2 and IBA-efflux by ABCG carriers, but it was dependent on IAA-influx by AUX1/LAX3.Taken together, the results demonstrate that a crosstalk involving ethylene signaling, IAA-influx, and IBA-to-IAA conversion exists between ethylene and IAA in the control of AR formation.	ethylene	4-12	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	139-143
28533791-0	2017	Jasmonoyl-L-Tryptophan Disrupts IAA Activity through the AUX1 Auxin Permease.	jasmonoyl-l-tryptophan	0-22	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	57-61
28533791-5	2017	A dominant mutant, called tryptophan conjugate response1-D that is insensitive to JA-Trp, but still sensitive to other active conjugates, was identified and the defect was found to be a substitution of Asn for Asp456 in the C-terminal domain of the IAA cellular permease AUX1.	Tryptophan	26-36	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	271-275
28533791-7	2017	These results suggest that JA-Trp disrupts AUX1 activity, but that endogenous JA-Trp has only a minor role in regulating plant growth.	ja-trp	27-33	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	43-47
27803131-5	2017	In particular, reduced PI(3,5)P2 levels caused abnormal membrane dynamics of plasma membrane proteins, AUX1 and BOR1, with different trafficking patterns.	phosphatidylinositol 3,5-diphosphate	23-32	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	103-107
27831474-7	2016	The ethylene effect was independent of auxin-signaling by TIR1-AFB2 and IBA-efflux by ABCG carriers, but it was dependent on IAA-influx by AUX1/LAX3.Taken together, the results demonstrate that a crosstalk involving ethylene signaling, IAA-influx, and IBA-to-IAA conversion exists between ethylene and IAA in the control of AR formation.	indoleacetic acid	125-128	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	139-143
26468517-7	2015	We show that Auxin Resistant1 (AUX1) is a critical component in the mediation of endogenous ethylene effects on LR formation under excess Fe stress.	Iron	138-140	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	13-29
27402709-4	2016	Strikingly, ROS treatment can also restore LR formation in pCASP1:shy2-2 and aux1 lax3 mutant lines in which auxin-mediated cell wall accommodation and remodeling in cells overlying the sites of LR formation is disrupted.	Reactive Oxygen Species	12-15	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	77-81
26232920-1	2015	MAIN CONCLUSION: The present study documented the action of a potential allelochemical, narciclasine, on auxin transport in Arabidopsis by mainly affecting subcellular trafficking of PIN and AUX1 proteins and through interfering actin cytoskeletal organization.	narciclasine	88-100	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	191-195
26904053-8	2016	Coincident with the salt-associated changes in redox profiles are changes in the distribution of auxin transporters (AUX1, PIN1/2), which become more diffuse in their localization.	Salts	20-24	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	117-121
26468517-0	2015	Auxin Resistant1 and PIN-FORMED2 Protect Lateral Root Formation in Arabidopsis under Iron Stress.	Iron	85-89	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	0-16
26468517-7	2015	We show that Auxin Resistant1 (AUX1) is a critical component in the mediation of endogenous ethylene effects on LR formation under excess Fe stress.	Iron	138-140	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	31-35
26468517-7	2015	We show that Auxin Resistant1 (AUX1) is a critical component in the mediation of endogenous ethylene effects on LR formation under excess Fe stress.	ethylene	92-100	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	13-29
26468517-7	2015	We show that Auxin Resistant1 (AUX1) is a critical component in the mediation of endogenous ethylene effects on LR formation under excess Fe stress.	ethylene	92-100	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	31-35
26468517-8	2015	Our findings demonstrate the relationship between excess Fe-dependent PIN2 expression and LR formation and the potential role of AUX1 in ethylene-mediated LR tolerance and suggest that AUX1 and PIN2 protect LR formation in Arabidopsis during the early stages of Fe stress.	Iron	57-59	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	185-189
26468517-8	2015	Our findings demonstrate the relationship between excess Fe-dependent PIN2 expression and LR formation and the potential role of AUX1 in ethylene-mediated LR tolerance and suggest that AUX1 and PIN2 protect LR formation in Arabidopsis during the early stages of Fe stress.	Iron	262-264	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	185-189
25906686-5	2015	The model reproduces auxin patterning and trends in wild-type and mutants; reveals that coordinated PIN and AUX1 activities are required to generate correct auxin patterning; correctly predicts shoot to root auxin flux, auxin patterning in the aux1 mutant, the amounts of cytokinin, ethylene and PIN protein, and PIN protein patterning in wild-type and mutant roots.	Cytokinins	272-281	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	108-112
25906686-5	2015	The model reproduces auxin patterning and trends in wild-type and mutants; reveals that coordinated PIN and AUX1 activities are required to generate correct auxin patterning; correctly predicts shoot to root auxin flux, auxin patterning in the aux1 mutant, the amounts of cytokinin, ethylene and PIN protein, and PIN protein patterning in wild-type and mutant roots.	Cytokinins	272-281	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	244-248
25906686-5	2015	The model reproduces auxin patterning and trends in wild-type and mutants; reveals that coordinated PIN and AUX1 activities are required to generate correct auxin patterning; correctly predicts shoot to root auxin flux, auxin patterning in the aux1 mutant, the amounts of cytokinin, ethylene and PIN protein, and PIN protein patterning in wild-type and mutant roots.	ethylene	283-291	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	108-112
25906686-5	2015	The model reproduces auxin patterning and trends in wild-type and mutants; reveals that coordinated PIN and AUX1 activities are required to generate correct auxin patterning; correctly predicts shoot to root auxin flux, auxin patterning in the aux1 mutant, the amounts of cytokinin, ethylene and PIN protein, and PIN protein patterning in wild-type and mutant roots.	ethylene	283-291	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	244-248
26109425-0	2015	Ethylene Inhibits Root Elongation during Alkaline Stress through AUXIN1 and Associated Changes in Auxin Accumulation.	ethylene	0-8	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	65-71
26109425-11	2015	Taken together, our results reveal that ethylene modulates alkaline stress-mediated inhibition of root growth by increasing auxin accumulation by stimulating the expression of AUX1 and auxin biosynthesis-related genes.	ethylene	40-48	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	176-180
26059335-5	2015	Genetic and gene expression analyses indicated that LBD16 and LBD18 act with AUX1 to regulate LR initiation and LR primordium development, and that AUX1 and LAX3 are needed for auxin-responsive expression of LBD16 and LBD18.	Indoleacetic Acids	177-182	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	148-152
22633819-7	2012	We further examined the effect of ABA on the expression of DR5::GUS and AtAUX1 in the model plant Arabidopsis.	Abscisic Acid	34-37	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	72-78
25922494-5	2015	The altered root growth in response to P and Mg supply was correlated with AUX1, PIN2, and PIN3 mRNA abundance and expression and the accumulation of the protein.	Phosphorus	39-40	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	75-79
25922494-5	2015	The altered root growth in response to P and Mg supply was correlated with AUX1, PIN2, and PIN3 mRNA abundance and expression and the accumulation of the protein.	Magnesium	45-47	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	75-79
23683587-9	2013	Additionally, there was less promotion of LR formation by Cd treatment in aux1-7 and pin2 mutants than that in the WT.	Cadmium	58-60	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	74-80
23683587-10	2013	Meanwhile, Cd stress also altered the expression of PINs and AUX1 in Arabidopsis roots, implying that the auxin transport pathway is required for Cd-modulated LR development.	Cadmium	11-13	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	61-65
23382554-7	2013	Enhanced shoot ethylene synthesis/signalling blocked recovery of LR production when auxin was applied in the presence of NH4(+) and negatively impacted shoot AUX1 expression.	ethylene	15-23	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	158-162
23293348-2	2013	This study isolated the AUXIN RESISTANT1 (AUX1) allele aux1(rcr1) (RCR1 for REVERSING CTR1-10 ROOT1) that suppressed the root growth inhibition conferred by the constitutive ethylene-response constitutive triple response1-10 (ctr1-10) allele.	ethylene	174-182	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	24-40
23293348-2	2013	This study isolated the AUXIN RESISTANT1 (AUX1) allele aux1(rcr1) (RCR1 for REVERSING CTR1-10 ROOT1) that suppressed the root growth inhibition conferred by the constitutive ethylene-response constitutive triple response1-10 (ctr1-10) allele.	ethylene	174-182	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	42-46
23293348-2	2013	This study isolated the AUXIN RESISTANT1 (AUX1) allele aux1(rcr1) (RCR1 for REVERSING CTR1-10 ROOT1) that suppressed the root growth inhibition conferred by the constitutive ethylene-response constitutive triple response1-10 (ctr1-10) allele.	ethylene	174-182	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	55-59
23293348-6	2013	Following treatment with the synthetic auxin 1-naphthaleneacetic acid (NAA), DR5:GUS expression in aux1(rcr1) and aux1-T occurred mainly in the root apex and mature zone.	1-naphthaleneacetic acid	45-69	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	99-103
23293348-6	2013	Following treatment with the synthetic auxin 1-naphthaleneacetic acid (NAA), DR5:GUS expression in aux1(rcr1) and aux1-T occurred mainly in the root apex and mature zone.	1-naphthaleneacetic acid	45-69	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	114-118
23293348-6	2013	Following treatment with the synthetic auxin 1-naphthaleneacetic acid (NAA), DR5:GUS expression in aux1(rcr1) and aux1-T occurred mainly in the root apex and mature zone.	1-naphthaleneacetic acid	71-74	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	99-103
23293348-7	2013	NAA-induced DR5:GUS expression in the root apex was markedly prevented by ethylene in genotypes with aux1(rcr1) but not in aux1-T genotypes and the wild type.	1-naphthaleneacetic acid	0-3	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	101-105
23293348-7	2013	NAA-induced DR5:GUS expression in the root apex was markedly prevented by ethylene in genotypes with aux1(rcr1) but not in aux1-T genotypes and the wild type.	1-naphthaleneacetic acid	0-3	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	123-127
23293348-7	2013	NAA-induced DR5:GUS expression in the root apex was markedly prevented by ethylene in genotypes with aux1(rcr1) but not in aux1-T genotypes and the wild type.	ethylene	74-82	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	101-105
23293348-9	2013	Green fluorescence protein-fused aux1(rcr1) was localized in the cytoplasm and probably not to the plasma membrane, indicating important roles of the Lys(126) residue at loop 2 in AUX1 targeting.	Lysine	150-153	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	33-37
23577185-8	2013	Ammonium also inhibits root gravitropism and concomitantly down-regulates the expression of two pivotal auxin transporters, AUX1 and PIN2.	Ammonium Compounds	0-8	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	124-128
23577185-9	2013	Insofar as ammonium inhibits root growth rate in AUX1 and PIN2 loss-of-function mutants almost as strongly as in wild type, we conclude that ammonium inhibits root growth and gravitropism by largely distinct pathways.	Ammonium Compounds	11-19	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	49-53
24800738-2	2014	1-Naphtoxyacetic acid (1-NOA), an analog of the synthetic auxin 1-N-naphtalene acetic acid (NAA), inhibits the IAA influx carrier AUX1.	1-naphtoxyacetic acid	0-21	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	130-134
24800738-2	2014	1-Naphtoxyacetic acid (1-NOA), an analog of the synthetic auxin 1-N-naphtalene acetic acid (NAA), inhibits the IAA influx carrier AUX1.	1-noa	23-28	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	130-134
24800738-2	2014	1-Naphtoxyacetic acid (1-NOA), an analog of the synthetic auxin 1-N-naphtalene acetic acid (NAA), inhibits the IAA influx carrier AUX1.	1-n-naphtalene acetic acid	64-90	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	130-134
24800738-2	2014	1-Naphtoxyacetic acid (1-NOA), an analog of the synthetic auxin 1-N-naphtalene acetic acid (NAA), inhibits the IAA influx carrier AUX1.	1-naphthaleneacetic acid	92-95	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	130-134
23489261-5	2013	Auxin transport inhibitors significantly reduced plant tolerance to As(III) in the WT, while exogenous supply of indole-3-acetic acid improved As(III) tolerance of aux1 and not that of WT.	indoleacetic acid	113-133	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	164-168
23489261-7	2013	As(III) increased the levels of H2 O2 in WT but not in aux1, suggesting a positive role for auxin transport through AUX1 on plant tolerance to As(III) stress via reactive oxygen species (ROS)-mediated signalling.	Hydrogen Peroxide	32-37	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	116-120
23489261-7	2013	As(III) increased the levels of H2 O2 in WT but not in aux1, suggesting a positive role for auxin transport through AUX1 on plant tolerance to As(III) stress via reactive oxygen species (ROS)-mediated signalling.	Reactive Oxygen Species	162-185	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	116-120
23489261-7	2013	As(III) increased the levels of H2 O2 in WT but not in aux1, suggesting a positive role for auxin transport through AUX1 on plant tolerance to As(III) stress via reactive oxygen species (ROS)-mediated signalling.	Reactive Oxygen Species	187-190	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	116-120
23489261-8	2013	Compared to the WT, the mutant aux1 was significantly more sensitive to high-temperature stress and salinity, also suggesting auxin transport influences a common element shared by plant tolerance to arsenite, salinity and high-temperature stress.	arsenite	199-207	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	31-35
23577185-9	2013	Insofar as ammonium inhibits root growth rate in AUX1 and PIN2 loss-of-function mutants almost as strongly as in wild type, we conclude that ammonium inhibits root growth and gravitropism by largely distinct pathways.	Ammonium Compounds	141-149	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	49-53
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	121-123	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	58-62
21992190-4	2012	Uptake kinetics of ABCB4 heterologously expressed in Schizosaccharomyces pombe differed from the saturation kinetics of AUX1 as uptake converted to efflux at threshold indole-3-acetic acid (IAA) concentrations.	indoleacetic acid	168-188	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	120-124
21992190-4	2012	Uptake kinetics of ABCB4 heterologously expressed in Schizosaccharomyces pombe differed from the saturation kinetics of AUX1 as uptake converted to efflux at threshold indole-3-acetic acid (IAA) concentrations.	indoleacetic acid	190-193	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	120-124
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	121-123	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	135-139
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Agar	266-270	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	58-62
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Agar	266-270	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	135-139
22234997-7	2012	We conclude that a local symplastic Fe gradient in lateral roots upregulates AUX1 to accumulate auxin in lateral root apices as a prerequisite for lateral root elongation.	Iron	36-38	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	77-81
21955623-3	2011	We recently demonstrated that AUX1, a well-studied component of auxin transport, mediates shoot-supplied ammonium (SSA) inhibition of lateral root (LR) formation in Arabidopsis.	Ammonium Compounds	105-113	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	30-34
22234997-0	2012	Localized iron supply triggers lateral root elongation in Arabidopsis by altering the AUX1-mediated auxin distribution.	Iron	10-14	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	86-90
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	67-69	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	58-62
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	67-69	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	135-139
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	67-69	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	209-213
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	121-123	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	58-62
22234997-6	2012	A crucial role of the auxin transporter AUXIN RESISTANT1 (AUX1) in Fe-triggered lateral root elongation was indicated by Fe-responsive AUX1 promoter activities in lateral root apices and by the failure of the aux1-T mutant to elongate lateral roots into Fe-enriched agar patches.	Iron	121-123	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	135-139
21955623-3	2011	We recently demonstrated that AUX1, a well-studied component of auxin transport, mediates shoot-supplied ammonium (SSA) inhibition of lateral root (LR) formation in Arabidopsis.	SerSA	115-118	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	30-34
20699398-6	2010	The opposite response was observed in a basipetal auxin transport impaired mutant aux1-7, which was slightly rescued by exogenous GSNO application.	S-Nitrosoglutathione	130-134	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	82-88
21771812-2	2011	Arabidopsis thaliana mutants, aux1, lax3, pin3 and pin7, which are defective in auxin influx and efflux proteins, were less sensitive to the inhibition of lateral root formation and stimulation of auxin transport following treatment with the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC).	ethylene	242-250	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	30-34
21771812-2	2011	Arabidopsis thaliana mutants, aux1, lax3, pin3 and pin7, which are defective in auxin influx and efflux proteins, were less sensitive to the inhibition of lateral root formation and stimulation of auxin transport following treatment with the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC).	1-aminocyclopropane-1-carboxylic acid	261-298	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	30-34
21771812-2	2011	Arabidopsis thaliana mutants, aux1, lax3, pin3 and pin7, which are defective in auxin influx and efflux proteins, were less sensitive to the inhibition of lateral root formation and stimulation of auxin transport following treatment with the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC).	1-aminocyclopropane-1-carboxylic acid	300-303	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	30-34
21666002-4	2011	Reduction of very-long-chain fatty acid sphingolipid levels leads in particular to auxin-dependent inhibition of lateral root emergence that is associated with selective aggregation of the plasma membrane auxin carriers AUX1 and PIN1 in the cytosol.	hexacosanoic acid	13-39	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	220-224
21666002-4	2011	Reduction of very-long-chain fatty acid sphingolipid levels leads in particular to auxin-dependent inhibition of lateral root emergence that is associated with selective aggregation of the plasma membrane auxin carriers AUX1 and PIN1 in the cytosol.	Sphingolipids	40-52	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	220-224
21084292-0	2011	Alkoxy-auxins are selective inhibitors of auxin transport mediated by PIN, ABCB, and AUX1 transporters.	alkoxy-auxins	0-13	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	85-89
21223394-7	2011	These pH dynamics are shown to be dependent on auxin, and specifically on auxin transport mediated by the auxin influx carrier AUX1 in cells of the lateral root cap and root epidermis.	Indoleacetic Acids	47-52	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	127-131
21955623-6	2011	Here, by analyzing both ABA- and auxin-related mutants, we show that AUX1 is also required for SSA-mediated suppression of primary root growth.	Abscisic Acid	24-27	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	69-73
21955623-8	2011	Taken together, our data identify AUX1-mediated auxin transport as a key transmission step in the sensing of excessive ammonium exposure and its inhibitory effect on root development.	Ammonium Compounds	119-127	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	34-38
20110325-0	2010	The auxin influx carriers AUX1 and LAX3 are involved in auxin-ethylene interactions during apical hook development in Arabidopsis thaliana seedlings.	ethylene	62-70	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	26-30
20826955-4	2010	Meanwhile, 35S-OsWRKY72 transgenic Arabidopsis displayed early flowering, reduced apical dominance, lost high temperature-induced hypocotyl elongation response, and enhanced gravitropism response, which were similar to the auxin-related gene mutants aux1, axr1 and bud1.	Sulfur-35	11-14	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	250-254
20826955-5	2010	Further, semi-quantitative RT-PCR showed that the expression patterns of three auxin-related genes AUX1, AXR1 and BUD1 were significantly altered in rosette leaves and infl orescences of 35S-OsWRKY72 plants compared with control Arabidopsis, and two ABA-related genes ABA2 and ABI4 were induced in 35S-OsWRKY72 seedlings.	Abscisic Acid	250-253	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	99-103
20110325-8	2010	Finally, mutant analysis demonstrates that the auxin influx carrier LAX3 is indispensable for proper hook formation, whereas the auxin influx carrier AUX1 is involved in the hook exaggeration phenotype induced by ethylene.	ethylene	213-221	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	150-154
16816406-6	2006	The aux1-7 auxin transport mutant had reduced l-glutamate sensitivity, suggesting a possible interaction between l-glutamate and auxin signaling.	Glutamic Acid	46-57	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	4-10
19858117-7	2010	There was less inhibition of root elongation by Al(3+) in aux1-7 and pin2 mutants than in the wild type.	ALUMINUM ION	48-54	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	58-62
19858117-11	2010	Al(3+) and ACC increased transcripts of AUX1 and PIN2, and this effect was no longer observed in the presence of AVG and Co(2+).	ALUMINUM ION	0-6	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	40-44
19858117-12	2010	These findings indicate that Al(3+)-induced ethylene production is likely to act as a signal to alter auxin distribution in roots by disrupting AUX1- and PIN2-mediated auxin polar transport, leading to arrest of root elongation.	ALUMINUM ION	29-35	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	144-148
19858117-12	2010	These findings indicate that Al(3+)-induced ethylene production is likely to act as a signal to alter auxin distribution in roots by disrupting AUX1- and PIN2-mediated auxin polar transport, leading to arrest of root elongation.	ethylene	44-52	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	144-148
18614710-3	2008	The quantitative nature of the interaction between AUX1 and its transport substrate indole-3-acetic acid (IAA) is incompletely understood, and we sought to address this in the present investigation.	indoleacetic acid	84-104	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	51-55
18614710-3	2008	The quantitative nature of the interaction between AUX1 and its transport substrate indole-3-acetic acid (IAA) is incompletely understood, and we sought to address this in the present investigation.	indoleacetic acid	106-109	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	51-55
18614710-5	2008	These membranes proved suitable for determination of the binding of IAA to AUX1 and enabled us to determine a K(d) of 2.6 mum, comparable with estimates for the K(m) for IAA transport.	indoleacetic acid	68-71	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	75-79
18363780-11	2008	aux1-7 also has ACC-insensitive acropetal and basipetal IAA transport, as well as altered DR5-GUS expression, which is consistent with ethylene altering AUX1-mediated IAA uptake, and thereby blocking lateral root formation.	ethylene	135-143	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	0-4
18363780-11	2008	aux1-7 also has ACC-insensitive acropetal and basipetal IAA transport, as well as altered DR5-GUS expression, which is consistent with ethylene altering AUX1-mediated IAA uptake, and thereby blocking lateral root formation.	ethylene	135-143	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	153-157
17926040-3	2008	We showed that MeIAA was more potent than IAA in the inhibition of hypocotyl elongation and that MeIAA and naphthalene-acetic acid (NAA), but not IAA, rescued the hypocotyl gravitropic defects in dark-grown aux1.	methyl 2-(1H-indol-3-yl)acetate	97-102	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	207-211
17926040-3	2008	We showed that MeIAA was more potent than IAA in the inhibition of hypocotyl elongation and that MeIAA and naphthalene-acetic acid (NAA), but not IAA, rescued the hypocotyl gravitropic defects in dark-grown aux1.	Naphthaleneacetic Acids	107-130	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	207-211
17926040-3	2008	We showed that MeIAA was more potent than IAA in the inhibition of hypocotyl elongation and that MeIAA and naphthalene-acetic acid (NAA), but not IAA, rescued the hypocotyl gravitropic defects in dark-grown aux1.	Naphthaleneacetic Acids	132-135	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	207-211
18179606-7	2008	The map1 mutant caused minimal disease and DON accumulation in both hosts.	deoxynivalenol	43-46	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	4-8
17114355-6	2006	AUX1 subcellular dynamics are not influenced by the auxin influx inhibitor NOA but are blocked by the auxin efflux inhibitors TIBA and PBA.	noa	75-78	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	0-4
17114355-6	2006	AUX1 subcellular dynamics are not influenced by the auxin influx inhibitor NOA but are blocked by the auxin efflux inhibitors TIBA and PBA.	2,3,5-triiodobenzoic acid	126-130	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	0-4
17114355-7	2006	Furthermore, auxin transport inhibitors and interference with the sterol composition of membranes disrupt polar AUX1 distribution at the plasma membrane.	Sterols	66-72	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	112-116
16816406-6	2006	The aux1-7 auxin transport mutant had reduced l-glutamate sensitivity, suggesting a possible interaction between l-glutamate and auxin signaling.	Glutamic Acid	113-124	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	4-10
16310363-5	2005	Application of cis-CA to seedlings of both wild type Arabidopsis and auxin-insensitive mutants, aux1 and axr2, resulted in nearly identical dose response curves in root growth, indicating that the mode of action by which cis-CA affects plant growth is different from that of auxins.	cis-ca	15-21	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	96-100
15889272-5	2005	Similarly, chromogenic staining of ProDc3:GUS activity showed that the aux1 and axr4 mutants gave predictable hypomorphic ProDc3:GUS expression phenotypes in roots treated with IAA or 2, 4-D: , but not the diffusible auxin NAA.	Naphthaleneacetic Acids	223-226	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	71-75
15889272-7	2005	Interestingly, the aux1 and axr4 mutants showed a hypomorphic effect on ABA-inducible ProDc3:GUS expression, demonstrating that ABA and IAA signaling pathways interact in roots.	Abscisic Acid	72-75	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	19-23
15889272-7	2005	Interestingly, the aux1 and axr4 mutants showed a hypomorphic effect on ABA-inducible ProDc3:GUS expression, demonstrating that ABA and IAA signaling pathways interact in roots.	Abscisic Acid	128-131	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	19-23
15681659-1	2005	Protein N-terminal methionine (Met) excision (NME) is carried out by two types of Met aminopeptidases (MAPs), MAP1 and MAP2, in eukaryotes.	Methionine	19-29	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	110-114