PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23163883-6	2013	Relocalization of PIN1 and PIN2 proteins after prolonged brefeldin-A treatment is largely impaired in these mutants.	Brefeldin A	57-68	Auxin efflux carrier family protein	Arabidopsis thaliana	27-31
21951802-4	2011	To further elucidate the molecular mechanisms underlying jasmonate-mediated reduction of plasma membrane (PM)-resident PIN2 abundance, we have conducted a genetic screen to identify suppressors of asa1-1 (soa), which showed lateral root formation in the presence of jasmonate.	jasmonic acid	57-66	Auxin efflux carrier family protein	Arabidopsis thaliana	119-123
23577185-8	2013	Ammonium also inhibits root gravitropism and concomitantly down-regulates the expression of two pivotal auxin transporters, AUX1 and PIN2.	Ammonium Compounds	0-8	Auxin efflux carrier family protein	Arabidopsis thaliana	133-137
23577185-9	2013	Insofar as ammonium inhibits root growth rate in AUX1 and PIN2 loss-of-function mutants almost as strongly as in wild type, we conclude that ammonium inhibits root growth and gravitropism by largely distinct pathways.	Ammonium Compounds	11-19	Auxin efflux carrier family protein	Arabidopsis thaliana	58-62
23429403-6	2013	Root gravitropism, PIN2 (an auxin efflux carrier) abundance, H+ efflux or Ca2+ influx in root apexes, were weaker in IPG-grown roots than those in TPG-grown roots.	2-Isopropoxyethanol	117-120	Auxin efflux carrier family protein	Arabidopsis thaliana	19-23
23577185-9	2013	Insofar as ammonium inhibits root growth rate in AUX1 and PIN2 loss-of-function mutants almost as strongly as in wild type, we conclude that ammonium inhibits root growth and gravitropism by largely distinct pathways.	Ammonium Compounds	141-149	Auxin efflux carrier family protein	Arabidopsis thaliana	58-62
22556266-0	2012	Lysine63-linked ubiquitylation of PIN2 auxin carrier protein governs hormonally controlled adaptation of Arabidopsis root growth.	lysine63	0-8	Auxin efflux carrier family protein	Arabidopsis thaliana	34-38
22556266-6	2012	Moreover, we provide experimental evidence indicating that PIN2 vacuolar sorting depends on modification specifically by lysine(63)-linked ubiquitin chains.	Lysine	121-127	Auxin efflux carrier family protein	Arabidopsis thaliana	59-63
21894193-5	2012	In addition, analysis using the membrane-selective dye FM4-64 revealed the decelerated vesicle trafficking caused by PtdIns(4,5)P(2) reduction, which hence results in suppressed cycling of PIN proteins (PIN2 and 3), and delayed redistribution of PIN2 and auxin under gravistimulation in pip5k2 roots.	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)	117-129	Auxin efflux carrier family protein	Arabidopsis thaliana	203-213
21894193-5	2012	In addition, analysis using the membrane-selective dye FM4-64 revealed the decelerated vesicle trafficking caused by PtdIns(4,5)P(2) reduction, which hence results in suppressed cycling of PIN proteins (PIN2 and 3), and delayed redistribution of PIN2 and auxin under gravistimulation in pip5k2 roots.	1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)	117-129	Auxin efflux carrier family protein	Arabidopsis thaliana	203-207
22374399-6	2012	In the nph3 mutant, both dark and BL BFA treatments caused the disappearance of PIN2-GFP from VLCs.	Brefeldin A	37-40	Auxin efflux carrier family protein	Arabidopsis thaliana	80-84
22374399-7	2012	However, in the phot1 mutant, PIN2-GFP remained within VLCs under both dark and BL BFA treatments, suggesting that phot1 and NPH3 play different roles in PIN2 localization.	Brefeldin A	83-86	Auxin efflux carrier family protein	Arabidopsis thaliana	30-34
22374399-7	2012	However, in the phot1 mutant, PIN2-GFP remained within VLCs under both dark and BL BFA treatments, suggesting that phot1 and NPH3 play different roles in PIN2 localization.	Brefeldin A	83-86	Auxin efflux carrier family protein	Arabidopsis thaliana	154-158
21951802-7	2011	In addition, jasmonate-induced PIN2:GFP reduction was blocked in these two mutants.	jasmonic acid	13-22	Auxin efflux carrier family protein	Arabidopsis thaliana	31-35
21466556-2	2011	Here, we report two distinct aspects of CORONATINE INSENSITIVE 1 (COI1)- and AUXIN RESISTANT 1 (AXR1)-dependent methyl jasmonate (MeJA) effects on PIN2 subcellular distribution: at lower concentration (5 muM), MeJA inhibits PIN2 endocytosis, whereas, at higher concentration (50 muM), MeJA reduces PIN2 accumulation in the plasma membrane.	methyl jasmonate	112-128	Auxin efflux carrier family protein	Arabidopsis thaliana	147-151
21466556-2	2011	Here, we report two distinct aspects of CORONATINE INSENSITIVE 1 (COI1)- and AUXIN RESISTANT 1 (AXR1)-dependent methyl jasmonate (MeJA) effects on PIN2 subcellular distribution: at lower concentration (5 muM), MeJA inhibits PIN2 endocytosis, whereas, at higher concentration (50 muM), MeJA reduces PIN2 accumulation in the plasma membrane.	methyl jasmonate	112-128	Auxin efflux carrier family protein	Arabidopsis thaliana	224-228
21466556-2	2011	Here, we report two distinct aspects of CORONATINE INSENSITIVE 1 (COI1)- and AUXIN RESISTANT 1 (AXR1)-dependent methyl jasmonate (MeJA) effects on PIN2 subcellular distribution: at lower concentration (5 muM), MeJA inhibits PIN2 endocytosis, whereas, at higher concentration (50 muM), MeJA reduces PIN2 accumulation in the plasma membrane.	methyl jasmonate	112-128	Auxin efflux carrier family protein	Arabidopsis thaliana	224-228
20516080-7	2010	Treatment with brefeldin A induces slower PIN2 protein aggregation in mips1, indicating altered PIN2 trafficking.	Brefeldin A	15-26	Auxin efflux carrier family protein	Arabidopsis thaliana	42-46
21494100-4	2011	We found that Trp treatment enhanced lateral root formation and, by screening for mutants in which the effect of Trp on lateral root formation was enhanced, we isolated the mm31 mutant.	Tryptophan	14-17	Auxin efflux carrier family protein	Arabidopsis thaliana	173-177
21494100-4	2011	We found that Trp treatment enhanced lateral root formation and, by screening for mutants in which the effect of Trp on lateral root formation was enhanced, we isolated the mm31 mutant.	Tryptophan	113-116	Auxin efflux carrier family protein	Arabidopsis thaliana	173-177
20516080-7	2010	Treatment with brefeldin A induces slower PIN2 protein aggregation in mips1, indicating altered PIN2 trafficking.	Brefeldin A	15-26	Auxin efflux carrier family protein	Arabidopsis thaliana	96-100
19858117-7	2010	There was less inhibition of root elongation by Al(3+) in aux1-7 and pin2 mutants than in the wild type.	ALUMINUM ION	48-54	Auxin efflux carrier family protein	Arabidopsis thaliana	69-73
19858117-12	2010	These findings indicate that Al(3+)-induced ethylene production is likely to act as a signal to alter auxin distribution in roots by disrupting AUX1- and PIN2-mediated auxin polar transport, leading to arrest of root elongation.	ethylene	44-52	Auxin efflux carrier family protein	Arabidopsis thaliana	154-158
19858117-11	2010	Al(3+) and ACC increased transcripts of AUX1 and PIN2, and this effect was no longer observed in the presence of AVG and Co(2+).	ALUMINUM ION	0-6	Auxin efflux carrier family protein	Arabidopsis thaliana	49-53
19858117-12	2010	These findings indicate that Al(3+)-induced ethylene production is likely to act as a signal to alter auxin distribution in roots by disrupting AUX1- and PIN2-mediated auxin polar transport, leading to arrest of root elongation.	ALUMINUM ION	29-35	Auxin efflux carrier family protein	Arabidopsis thaliana	154-158
19841669-5	2008	By exploiting salt overly sensitive (sos) mutants and PIN2 expression analyses, we have shown that the altered root growth direction in response to salt is mediated by ion disequilibrium and is correlated with PIN2 mRNA abundance and expression and localization of the protein.	Salts	148-152	Auxin efflux carrier family protein	Arabidopsis thaliana	54-58
19841669-5	2008	By exploiting salt overly sensitive (sos) mutants and PIN2 expression analyses, we have shown that the altered root growth direction in response to salt is mediated by ion disequilibrium and is correlated with PIN2 mRNA abundance and expression and localization of the protein.	Salts	148-152	Auxin efflux carrier family protein	Arabidopsis thaliana	210-214
17653191-7	2007	Furthermore, in BFA-treated gnl1 roots, the internalization of a polar plasma-membrane marker, the auxin efflux carrier PIN2, was selectively inhibited.	Brefeldin A	16-19	Auxin efflux carrier family protein	Arabidopsis thaliana	120-124
18024552-7	2008	The altered root growth direction in response to salt was found to be correlated with PIN-FORMED2 (PIN2) messenger RNA abundance and expression and localization of the protein.	Salts	49-53	Auxin efflux carrier family protein	Arabidopsis thaliana	86-97
18024552-7	2008	The altered root growth direction in response to salt was found to be correlated with PIN-FORMED2 (PIN2) messenger RNA abundance and expression and localization of the protein.	Salts	49-53	Auxin efflux carrier family protein	Arabidopsis thaliana	99-103
18024552-10	2008	These results indicate that the SOS pathway may mediate the decrease of PIN2 messenger RNA in salinity-induced modification of gravitropic response in Arabidopsis roots.	sulfur monoxide	32-35	Auxin efflux carrier family protein	Arabidopsis thaliana	72-76
16141452-6	2005	Constitutive overexpression of ROP2 results in enhanced polar accumulation of PIN2 protein in the root elongation region and increased gravitropism, which is significantly affected by latrunculin B, an inhibitor of F-actin assembly.	latrunculin B	184-197	Auxin efflux carrier family protein	Arabidopsis thaliana	78-82
16936718-6	2006	In root cells, we further show that AtSNX1 localizes to an endosomal compartment distinct from GNOM-containing endosomes, and that PIN2 accumulates in this compartment after treatment with the phosphatidylinositol-3-OH kinase inhibitor wortmannin or after a gravity stimulus.	Wortmannin	236-246	Auxin efflux carrier family protein	Arabidopsis thaliana	131-135
15807782-7	2005	Our data suggest that protein phosphatases, sensitive to cantharidin and okadaic acid, are likely involved in regulating AGR1/PIN2-mediated root basipetal auxin transport and gravitropism, as well as auxin response in the root central elongation zone (CEZ).	Cantharidin	57-68	Auxin efflux carrier family protein	Arabidopsis thaliana	121-125
15807782-7	2005	Our data suggest that protein phosphatases, sensitive to cantharidin and okadaic acid, are likely involved in regulating AGR1/PIN2-mediated root basipetal auxin transport and gravitropism, as well as auxin response in the root central elongation zone (CEZ).	Cantharidin	57-68	Auxin efflux carrier family protein	Arabidopsis thaliana	126-130
15807782-7	2005	Our data suggest that protein phosphatases, sensitive to cantharidin and okadaic acid, are likely involved in regulating AGR1/PIN2-mediated root basipetal auxin transport and gravitropism, as well as auxin response in the root central elongation zone (CEZ).	Okadaic Acid	73-85	Auxin efflux carrier family protein	Arabidopsis thaliana	121-125
15807782-7	2005	Our data suggest that protein phosphatases, sensitive to cantharidin and okadaic acid, are likely involved in regulating AGR1/PIN2-mediated root basipetal auxin transport and gravitropism, as well as auxin response in the root central elongation zone (CEZ).	Okadaic Acid	73-85	Auxin efflux carrier family protein	Arabidopsis thaliana	126-130
12932321-7	2003	BFA causes coaccumulation of sterols, endocytic markers like ARA6-GFP, and PIN2, a polarly localized presumptive auxin transport protein, in early endosome agglomerations that can be distinguished from ER and Golgi.	Brefeldin A	0-3	Auxin efflux carrier family protein	Arabidopsis thaliana	75-79
9871369-2	1998	Root growth of agr mutants is moderately resistant to ethylene and to an auxin transport inhibitor.	ethylene	54-62	Auxin efflux carrier family protein	Arabidopsis thaliana	15-18
9844024-0	1998	The arabidopsis thaliana AGRAVITROPIC 1 gene encodes a component of the polar-auxin-transport efflux carrier.	Indoleacetic Acids	78-83	Auxin efflux carrier family protein	Arabidopsis thaliana	25-39
9844024-6	1998	Here we show that mutations in the Arabidopsis thaliana AGRAVITROPIC 1 (AGR1) gene involved in root gravitropism confer increased root-growth sensitivity to auxin and decreased sensitivity to ethylene and an auxin transport inhibitor, and cause retention of exogenously added auxin in root tip cells.	ethylene	192-200	Auxin efflux carrier family protein	Arabidopsis thaliana	56-70
9844024-6	1998	Here we show that mutations in the Arabidopsis thaliana AGRAVITROPIC 1 (AGR1) gene involved in root gravitropism confer increased root-growth sensitivity to auxin and decreased sensitivity to ethylene and an auxin transport inhibitor, and cause retention of exogenously added auxin in root tip cells.	ethylene	192-200	Auxin efflux carrier family protein	Arabidopsis thaliana	72-76
9844024-6	1998	Here we show that mutations in the Arabidopsis thaliana AGRAVITROPIC 1 (AGR1) gene involved in root gravitropism confer increased root-growth sensitivity to auxin and decreased sensitivity to ethylene and an auxin transport inhibitor, and cause retention of exogenously added auxin in root tip cells.	Indoleacetic Acids	157-162	Auxin efflux carrier family protein	Arabidopsis thaliana	56-70
9844024-6	1998	Here we show that mutations in the Arabidopsis thaliana AGRAVITROPIC 1 (AGR1) gene involved in root gravitropism confer increased root-growth sensitivity to auxin and decreased sensitivity to ethylene and an auxin transport inhibitor, and cause retention of exogenously added auxin in root tip cells.	Indoleacetic Acids	157-162	Auxin efflux carrier family protein	Arabidopsis thaliana	72-76
11266581-4	2001	By contrast, in the presence of 10 nM 1-naphthaleneacetic acid (NAA), the concentrations of ethylene required to induce I(50) in eir1-1 and aux1-7 roots were greatly reduced nearly to the level required in wild-type roots.	1-naphthaleneacetic acid	38-62	Auxin efflux carrier family protein	Arabidopsis thaliana	129-135
11266581-4	2001	By contrast, in the presence of 10 nM 1-naphthaleneacetic acid (NAA), the concentrations of ethylene required to induce I(50) in eir1-1 and aux1-7 roots were greatly reduced nearly to the level required in wild-type roots.	1-naphthaleneacetic acid	64-67	Auxin efflux carrier family protein	Arabidopsis thaliana	129-135
11266581-4	2001	By contrast, in the presence of 10 nM 1-naphthaleneacetic acid (NAA), the concentrations of ethylene required to induce I(50) in eir1-1 and aux1-7 roots were greatly reduced nearly to the level required in wild-type roots.	ethylene	92-100	Auxin efflux carrier family protein	Arabidopsis thaliana	129-135
9871369-3	1998	Vertically placed agr roots grow into agar medium containing IAA or naphthalene-1-acetic acid, but not into medium containing 2,4-D.	Agar	38-42	Auxin efflux carrier family protein	Arabidopsis thaliana	18-21
9871369-3	1998	Vertically placed agr roots grow into agar medium containing IAA or naphthalene-1-acetic acid, but not into medium containing 2,4-D.	indoleacetic acid	61-64	Auxin efflux carrier family protein	Arabidopsis thaliana	18-21
9871369-3	1998	Vertically placed agr roots grow into agar medium containing IAA or naphthalene-1-acetic acid, but not into medium containing 2,4-D.	1-naphthaleneacetic acid	68-93	Auxin efflux carrier family protein	Arabidopsis thaliana	18-21
9679062-2	1998	This gene is expressed only in the root, which is consistent with the phenotypes of the eir1 mutants-the roots are agravitropic and have a reduced sensitivity to ethylene.	ethylene	162-170	Auxin efflux carrier family protein	Arabidopsis thaliana	88-92
9807815-6	1998	Expression of the abi1-1 dominant mutation blocked accumulation of the drought-induced TAS14 and LE25 mRNAs in response to ABA, as well as ABA- and wound-induced expression of the defense-associated pin2 and LAP transcripts.	Abscisic Acid	139-142	Auxin efflux carrier family protein	Arabidopsis thaliana	199-203
9807815-8	1998	These results indicate that abi1-1 inhibits wound-induced expression of the pin2 and LAP transcripts by blocking ABA-induction of these genes.	Abscisic Acid	113-116	Auxin efflux carrier family protein	Arabidopsis thaliana	76-80
9679062-5	1998	Expression of the EIR1 gene in Saccharomyces cerevisiae confers resistance to fluorinated indolic compounds.	indolic compounds	90-107	Auxin efflux carrier family protein	Arabidopsis thaliana	18-22
7768447-5	1995	The fifth complementation group, eir1, is defined by a novel class of mutants that have agravitropic and ethylene-insensitive roots.	ethylene	105-113	Auxin efflux carrier family protein	Arabidopsis thaliana	33-37
7768447-12	1995	The EIR1, AUX1 and HLS1 genes may function in the interactions between ethylene and other plant hormones that occur late in the signaling pathway of this simple gas.	ethylene	71-79	Auxin efflux carrier family protein	Arabidopsis thaliana	4-8
33763094-9	2021	The membrane abundance of PIN2, a facilitator of shootward auxin transport, was significantly reduced following ABA treatment and in cyp707a1,3.	Indoleacetic Acids	59-64	Auxin efflux carrier family protein	Arabidopsis thaliana	26-30
33819781-6	2021	The transcription level of auxin biosynthesis related genes decreases and the abundance of auxin efflux carriers PIN1 and PIN2 declines after 40 mg/L CDs treatment, thus lowering the auxin level in root tips.	cds	150-153	Auxin efflux carrier family protein	Arabidopsis thaliana	122-126
33763094-0	2021	Abscisic Acid Regulates the Root Growth Trajectory by Reducing Auxin Transporter PIN2 Protein Levels in Arabidopsis thaliana.	Abscisic Acid	0-13	Auxin efflux carrier family protein	Arabidopsis thaliana	81-85
33763094-9	2021	The membrane abundance of PIN2, a facilitator of shootward auxin transport, was significantly reduced following ABA treatment and in cyp707a1,3.	Abscisic Acid	112-115	Auxin efflux carrier family protein	Arabidopsis thaliana	26-30
33763094-10	2021	Finally, we revealed that ABA reduced the membrane PIN2 intensity through suppressing the PIN2 expression rather than accelerating PIN2 degradation.	Abscisic Acid	26-29	Auxin efflux carrier family protein	Arabidopsis thaliana	51-55
33763094-10	2021	Finally, we revealed that ABA reduced the membrane PIN2 intensity through suppressing the PIN2 expression rather than accelerating PIN2 degradation.	Abscisic Acid	26-29	Auxin efflux carrier family protein	Arabidopsis thaliana	90-94
33763094-10	2021	Finally, we revealed that ABA reduced the membrane PIN2 intensity through suppressing the PIN2 expression rather than accelerating PIN2 degradation.	Abscisic Acid	26-29	Auxin efflux carrier family protein	Arabidopsis thaliana	90-94
34618941-0	2022	Abscisic acid employs NRP-dependent PIN2 vacuolar degradation to suppress auxin-mediated primary root elongation in Arabidopsis.	Abscisic Acid	0-13	Auxin efflux carrier family protein	Arabidopsis thaliana	36-40
34758285-6	2022	Consistent with AUX1 and PIN2 accumulation being mediated via ethylene signaling,3 expression of 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 7 (ACS7) is increased at low Pi in a KAI2-dependent manner, and treatment with an ethylene precursor restores RH elongation of acs7, but not of aux1 and pin2.	ethylene	62-70	Auxin efflux carrier family protein	Arabidopsis thaliana	25-29
34758285-7	2022	Thus, KAI2 signaling is increased by phosphate starvation to trigger an ethylene- AUX1/PIN2-auxin cascade required for RH elongation.	Phosphates	37-46	Auxin efflux carrier family protein	Arabidopsis thaliana	87-91
34758285-7	2022	Thus, KAI2 signaling is increased by phosphate starvation to trigger an ethylene- AUX1/PIN2-auxin cascade required for RH elongation.	ethylene	72-80	Auxin efflux carrier family protein	Arabidopsis thaliana	87-91
34618941-6	2022	The auxin efflux carrier PIN2 over-accumulated in nrp1 nrp2 and became de-polarized at the plasma membrane, leading to slower root basipetal auxin transport.	Indoleacetic Acids	4-9	Auxin efflux carrier family protein	Arabidopsis thaliana	25-29
34618941-6	2022	The auxin efflux carrier PIN2 over-accumulated in nrp1 nrp2 and became de-polarized at the plasma membrane, leading to slower root basipetal auxin transport.	Indoleacetic Acids	141-146	Auxin efflux carrier family protein	Arabidopsis thaliana	25-29
34618941-8	2022	Furthermore, ABA can induce NRP-dependent vacuolar degradation of PIN2 to inhibit primary root elongation.	Abscisic Acid	13-16	Auxin efflux carrier family protein	Arabidopsis thaliana	66-70
34816076-0	2021	Electrophysiological study of Arabidopsis ABCB4 and PIN2 auxin transporters: Evidence of auxin activation and interaction enhancing auxin selectivity.	Indoleacetic Acids	89-94	Auxin efflux carrier family protein	Arabidopsis thaliana	52-56
34982825-6	2022	The trafficking of the auxin transporter PIN2 was disturbed in this lpaat4;lpaat5 double mutant treated with CI976, whereas trafficking of H+-ATPases was unaffected.	PD 128042	109-114	Auxin efflux carrier family protein	Arabidopsis thaliana	41-45
34816076-0	2021	Electrophysiological study of Arabidopsis ABCB4 and PIN2 auxin transporters: Evidence of auxin activation and interaction enhancing auxin selectivity.	Indoleacetic Acids	132-137	Auxin efflux carrier family protein	Arabidopsis thaliana	52-56
34451648-6	2021	Through a pharmacological and microscopic approach, it was underlined that this saponin modified both auxin distribution and transport, causing an auxin accumulation in the region of root maturation and an alteration of proteins responsible for the auxin efflux (PIN2).	Saponins	80-87	Auxin efflux carrier family protein	Arabidopsis thaliana	263-267
34357701-0	2021	Nitrate triggered phosphoproteome changes and a PIN2 phosphosite modulating root system architecture.	Nitrates	0-7	Auxin efflux carrier family protein	Arabidopsis thaliana	48-52
34357701-8	2021	We validated a new phosphorylation site in PIN2 and provide evidence that it functions in primary and lateral root growth responses to nitrate.	Nitrates	135-142	Auxin efflux carrier family protein	Arabidopsis thaliana	43-47
34451648-6	2021	Through a pharmacological and microscopic approach, it was underlined that this saponin modified both auxin distribution and transport, causing an auxin accumulation in the region of root maturation and an alteration of proteins responsible for the auxin efflux (PIN2).	Indoleacetic Acids	102-107	Auxin efflux carrier family protein	Arabidopsis thaliana	263-267
34451648-6	2021	Through a pharmacological and microscopic approach, it was underlined that this saponin modified both auxin distribution and transport, causing an auxin accumulation in the region of root maturation and an alteration of proteins responsible for the auxin efflux (PIN2).	Indoleacetic Acids	249-254	Auxin efflux carrier family protein	Arabidopsis thaliana	263-267
32901934-0	2021	Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana.	Salicylic Acid	0-14	Auxin efflux carrier family protein	Arabidopsis thaliana	25-29
34088085-9	2021	However, MCY-LR complemented the altered gravitropic response of crk5-1 mutants, defective in a protein kinase with essential role in the correct membrane localization of PIN2.	cyanoginosin LR	9-15	Auxin efflux carrier family protein	Arabidopsis thaliana	171-175
34205973-0	2021	The AtCRK5 Protein Kinase Is Required to Maintain the ROS NO Balance Affecting the PIN2-Mediated Root Gravitropic Response in Arabidopsis.	ros	54-57	Auxin efflux carrier family protein	Arabidopsis thaliana	83-87
34205973-2	2021	Among others, the Atcrk5-1 mutant was reported to exhibit a delayed gravitropic response via compromised PIN2-mediated auxin transport at the root tip.	Indoleacetic Acids	119-124	Auxin efflux carrier family protein	Arabidopsis thaliana	105-109
34205973-10	2021	The potential involvement of AtCRK5 protein kinase in the control of auxin-ROS-NO-PIN2-auxin regulatory loop is discussed.	ros	75-78	Auxin efflux carrier family protein	Arabidopsis thaliana	82-86
35274300-0	2022	SAV4 is required for ethylene-induced root hair growth through stabilizing PIN2 auxin transporter in Arabidopsis.	ethylene	21-29	Auxin efflux carrier family protein	Arabidopsis thaliana	75-79
35274300-3	2022	Ethylene promotes root hair development through increasing PIN2 abundance in root tips, which subsequently leads to enhanced expression of auxin reporter genes.	ethylene	0-8	Auxin efflux carrier family protein	Arabidopsis thaliana	59-63
35274300-9	2022	Vacuolar degradation of PIN2 is suppressed by ethylene, which was weakened in sav4 mutant.	ethylene	46-54	Auxin efflux carrier family protein	Arabidopsis thaliana	24-28
35274300-10	2022	Furthermore, SAV4 affects the formation of PIN2 clusters and its lateral diffusion on the PM.	sav4	13-17	Auxin efflux carrier family protein	Arabidopsis thaliana	43-47
33673672-5	2021	The involvement of ethylene/auxin crosstalk in the salt stress response was evaluated by introducing auxin reporters for local biosynthesis (pTAR2::GUS) and polar transport (pLAX3::GUS, pAUX1::AUX1-YFP, pPIN1::PIN1-GFP, pPIN2::PIN2-GFP, pPIN3::GUS) in the mutants.	Salts	51-55	Auxin efflux carrier family protein	Arabidopsis thaliana	221-225
34088085-5	2021	Relatively short-term (24 h) MCY-LR treatments decreased the levels of PIN1, PIN2 and PIN7, but not of PIN3 in tips of primary roots.	cyanoginosin LR	29-35	Auxin efflux carrier family protein	Arabidopsis thaliana	77-81
34299366-11	2021	The hypersensitive response of act7-4 mutant was found to be linked to the altered intracellular auxin distribution, resulted from the reduced abundance of PIN-FORMED PIN1 and PIN2 efflux carriers.	Indoleacetic Acids	97-102	Auxin efflux carrier family protein	Arabidopsis thaliana	176-180
32901934-4	2021	Here we revealed an underlying mechanism of SA regulating auxin signaling by constraining the plasma membrane dynamics of PIN2 auxin efflux transporter in Arabidopsis thaliana roots.	Salicylic Acid	44-46	Auxin efflux carrier family protein	Arabidopsis thaliana	122-126
32901934-8	2021	Our results demonstrate a defense-growth tradeoff mechanism, by which SA signaling crosstalks with auxin transportation by concentrating membrane-resident PIN2 into heterogeneous compartments.	Salicylic Acid	70-72	Auxin efflux carrier family protein	Arabidopsis thaliana	155-159
33288701-0	2020	Glucose-TOR signaling regulates PIN2 stability to orchestrate auxin gradient and cell expansion in Arabidopsis root.	Glucose	0-7	Auxin efflux carrier family protein	Arabidopsis thaliana	32-36
33288023-5	2021	In addition, l- isomers of Glu, Leu and Lys, but not l-Trp diminished the GFP fluorescence of pPIN1::PIN1:GFP, pPIN2::PIN2:GFP, pPIN3::PIN3:GFP and pPIN7::PIN7:GFP constructs in root tips.	Glutamic Acid	27-30	Auxin efflux carrier family protein	Arabidopsis thaliana	112-116
33288023-5	2021	In addition, l- isomers of Glu, Leu and Lys, but not l-Trp diminished the GFP fluorescence of pPIN1::PIN1:GFP, pPIN2::PIN2:GFP, pPIN3::PIN3:GFP and pPIN7::PIN7:GFP constructs in root tips.	Leucine	32-35	Auxin efflux carrier family protein	Arabidopsis thaliana	112-116
33288023-5	2021	In addition, l- isomers of Glu, Leu and Lys, but not l-Trp diminished the GFP fluorescence of pPIN1::PIN1:GFP, pPIN2::PIN2:GFP, pPIN3::PIN3:GFP and pPIN7::PIN7:GFP constructs in root tips.	Lysine	40-43	Auxin efflux carrier family protein	Arabidopsis thaliana	112-116
33288701-4	2020	Here, using a large-scale Arabidopsis mutant screening, we described the identification of PIN2 (PIN-FORMED 2), an auxin efflux facilitator, as a key downstream regulator in glucose-TOR (target of rapamycin) energy signaling.	Glucose	174-181	Auxin efflux carrier family protein	Arabidopsis thaliana	91-95
33288701-4	2020	Here, using a large-scale Arabidopsis mutant screening, we described the identification of PIN2 (PIN-FORMED 2), an auxin efflux facilitator, as a key downstream regulator in glucose-TOR (target of rapamycin) energy signaling.	Glucose	174-181	Auxin efflux carrier family protein	Arabidopsis thaliana	97-109
33288701-5	2020	We demonstrate that glucose-activated TOR phosphorylates and stabilizes PIN2 and therefore influences the gradient distribution of PIN2 in the Arabidopsis primary root.	Glucose	20-27	Auxin efflux carrier family protein	Arabidopsis thaliana	72-76
33288701-5	2020	We demonstrate that glucose-activated TOR phosphorylates and stabilizes PIN2 and therefore influences the gradient distribution of PIN2 in the Arabidopsis primary root.	Glucose	20-27	Auxin efflux carrier family protein	Arabidopsis thaliana	131-135
33288701-6	2020	Interestingly, dysregulation of TOR or PIN2 disrupts the glucose-promoted low auxin region located in the elongation zone that is essential for cell elongation.	Glucose	57-64	Auxin efflux carrier family protein	Arabidopsis thaliana	39-43
32790800-0	2020	Endosidin 2 accelerates PIN2 endocytosis and disturbs intracellular trafficking of PIN2, PIN3, and PIN4 but not of SYT1.	endosidin 2	0-11	Auxin efflux carrier family protein	Arabidopsis thaliana	24-28
33202956-5	2020	The RAM DR5 signal was increased due to the up-regulation of the auxin biosynthesis TAA1 protein and down-regulation of PIN4 and PIN2, which can act as auxin sinks in the root tip.	Indoleacetic Acids	152-157	Auxin efflux carrier family protein	Arabidopsis thaliana	129-133
33023035-7	2020	Collectively, our results indicate that vacuolar NHX dependent cation/H+ antiport activity is needed for proper auxin homeostasis, likely by affecting intracellular trafficking and distribution of the PIN2 efflux carrier.	Indoleacetic Acids	112-117	Auxin efflux carrier family protein	Arabidopsis thaliana	201-205
32891072-5	2020	Suppressing polar auxin transport, either by pharmacological treatment or by introducing mutations at PIN-FORMED2 (PIN2) or AUXIN RESISTANT1 (AUX1), suppressed the asymmetric root growth (ARG) in fer-4, a null mutant of FER, indicating that FER-suppression of ARG depends on polar auxin transport.	Arginine	188-191	Auxin efflux carrier family protein	Arabidopsis thaliana	102-113
32891072-5	2020	Suppressing polar auxin transport, either by pharmacological treatment or by introducing mutations at PIN-FORMED2 (PIN2) or AUXIN RESISTANT1 (AUX1), suppressed the asymmetric root growth (ARG) in fer-4, a null mutant of FER, indicating that FER-suppression of ARG depends on polar auxin transport.	Arginine	188-191	Auxin efflux carrier family protein	Arabidopsis thaliana	115-119
32763980-9	2020	Fluorescence activation-coupled protein labeling (FAPL) with DRBG-488 was used to observe PIN2 endocytosis and delivery to the vacuole as well as preferential delivery of newly synthesized PIN2 to the actively forming cell plate during mitosis.	drbg-488	61-69	Auxin efflux carrier family protein	Arabidopsis thaliana	90-94
32790800-0	2020	Endosidin 2 accelerates PIN2 endocytosis and disturbs intracellular trafficking of PIN2, PIN3, and PIN4 but not of SYT1.	endosidin 2	0-11	Auxin efflux carrier family protein	Arabidopsis thaliana	83-87
32790800-1	2020	We established that Endosidin2 (ES2) affected the trafficking routes of both newly synthesized and endocytic pools of PIN-FORMED2 (PIN2) in Arabidopsis root epidermal cells.	endosidin 2	20-30	Auxin efflux carrier family protein	Arabidopsis thaliana	118-129
32790800-1	2020	We established that Endosidin2 (ES2) affected the trafficking routes of both newly synthesized and endocytic pools of PIN-FORMED2 (PIN2) in Arabidopsis root epidermal cells.	endosidin 2	20-30	Auxin efflux carrier family protein	Arabidopsis thaliana	131-135
32790800-1	2020	We established that Endosidin2 (ES2) affected the trafficking routes of both newly synthesized and endocytic pools of PIN-FORMED2 (PIN2) in Arabidopsis root epidermal cells.	endosidin 2	32-35	Auxin efflux carrier family protein	Arabidopsis thaliana	118-129
32790800-1	2020	We established that Endosidin2 (ES2) affected the trafficking routes of both newly synthesized and endocytic pools of PIN-FORMED2 (PIN2) in Arabidopsis root epidermal cells.	endosidin 2	32-35	Auxin efflux carrier family protein	Arabidopsis thaliana	131-135
32733502-8	2020	Using the conditional feature of this mutation, we show that altered trafficking of PIN2 precedes altered auxin transport and defects in gravitropism and lateral root development in this mutant upon transition to the restrictive temperature.	Indoleacetic Acids	106-111	Auxin efflux carrier family protein	Arabidopsis thaliana	84-88
32582237-0	2020	NRT1.1-Mediated Nitrate Suppression of Root Coiling Relies on PIN2- and AUX1-Mediated Auxin Transport.	Nitrates	16-23	Auxin efflux carrier family protein	Arabidopsis thaliana	62-66
32582237-6	2020	Nitrate deficiency caused root coiling on horizontal plates, which is inhibited by an auxin transport inhibitor, and by mutations in PIN-FORMED2 (PIN2) and AUXIN RESISTANT 1 (AUX1).	Nitrates	0-7	Auxin efflux carrier family protein	Arabidopsis thaliana	133-144
32582237-6	2020	Nitrate deficiency caused root coiling on horizontal plates, which is inhibited by an auxin transport inhibitor, and by mutations in PIN-FORMED2 (PIN2) and AUXIN RESISTANT 1 (AUX1).	Nitrates	0-7	Auxin efflux carrier family protein	Arabidopsis thaliana	146-150
32582237-8	2020	In addition, PIN2- and AUX1-mediated auxin transports are epistatic to NRT1.1 in nitrate deficiency-induced ARG.	Nitrates	81-88	Auxin efflux carrier family protein	Arabidopsis thaliana	13-17
31797871-0	2019	Brassinosteroid signaling delimits root gravitropism via sorting of the Arabidopsis PIN2 auxin transporter.	Brassinosteroids	0-15	Auxin efflux carrier family protein	Arabidopsis thaliana	84-88
32278957-5	2020	All the alterations suggest that norharmane alters polar auxin transport by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of A. thaliana seedlings.	norharman	33-43	Auxin efflux carrier family protein	Arabidopsis thaliana	87-91
31817249-6	2019	We have previously showed that AtCRK5 can regulate the PIN2 and PIN3 proteins either directly by phosphorylation or indirectly affecting the GA level during the root gravitropic and hypocotyl hook bending responses.	Indoleacetic Acids	141-143	Auxin efflux carrier family protein	Arabidopsis thaliana	55-59
31745997-0	2020	Phospholipase D-derived phosphatidic acid promotes root hair development under phosphorus deficiency by suppressing vacuolar degradation of PIN2.	Phosphatidic Acids	24-41	Auxin efflux carrier family protein	Arabidopsis thaliana	140-144
31745997-2	2020	We here demonstrated the roles of auxin efflux carrier PIN2 and phospholipase D (PLD)-derived phosphatidic acid (PA), a key signaling molecule, in promoting root hair development in Arabidopsis thaliana under low-phosphate (LP) condition.	Phosphates	213-222	Auxin efflux carrier family protein	Arabidopsis thaliana	55-59
31745997-3	2020	Root hair elongation under LP condition was greatly suppressed in pin2 mutant or under treatment with a PLDzeta2-specific inhibitor, revealing that PIN2 and polar auxin transport, and PLDzeta2-PA are crucial in LP responses.	Phosphatidic Acids	193-195	Auxin efflux carrier family protein	Arabidopsis thaliana	66-70
31745997-4	2020	PIN2 was accumulated and degraded in the vacuole under normal-phosphate (NP) condition, whereas its vacuolar accumulation was suppressed under LP or NP plus PA conditions.	Phosphates	62-71	Auxin efflux carrier family protein	Arabidopsis thaliana	0-4
31745997-4	2020	PIN2 was accumulated and degraded in the vacuole under normal-phosphate (NP) condition, whereas its vacuolar accumulation was suppressed under LP or NP plus PA conditions.	Phosphatidic Acids	157-159	Auxin efflux carrier family protein	Arabidopsis thaliana	0-4
31745997-7	2020	PA binds to SNX1 and promotes its accumulation at the plasma membrane, especially under LP condition, hence promotes root hair development by suppressing the vacuolar degradation of PIN2.	Phosphatidic Acids	0-2	Auxin efflux carrier family protein	Arabidopsis thaliana	182-186
31745997-8	2020	We uncovered a link between PLD-derived PA and SNX1-dependent vacuolar degradation of PIN2 in regulating root hair development under phosphorus deficiency.	Phosphatidic Acids	40-42	Auxin efflux carrier family protein	Arabidopsis thaliana	86-90
31750920-0	2020	Nickel Toxicity Targets Cell Wall-Related Processes and PIN2-Mediated Auxin Transport to Inhibit Root Elongation and Gravitropic Responses in Arabidopsis.	Nickel	0-6	Auxin efflux carrier family protein	Arabidopsis thaliana	56-60
31797871-3	2019	By employing a constitutively degraded version of PIN2, we identify brassinolides as antagonists of PIN2 endocytosis.	brassinolide	68-81	Auxin efflux carrier family protein	Arabidopsis thaliana	50-54
31797871-3	2019	By employing a constitutively degraded version of PIN2, we identify brassinolides as antagonists of PIN2 endocytosis.	brassinolide	68-81	Auxin efflux carrier family protein	Arabidopsis thaliana	100-104
31797871-5	2019	Brassinolide-controlled adjustments in PIN2 sorting and intracellular distribution governs formation of a lateral PIN2 gradient in gravistimulated roots, coinciding with adjustments in auxin signaling and directional root growth.	brassinolide	0-12	Auxin efflux carrier family protein	Arabidopsis thaliana	39-43
31797871-5	2019	Brassinolide-controlled adjustments in PIN2 sorting and intracellular distribution governs formation of a lateral PIN2 gradient in gravistimulated roots, coinciding with adjustments in auxin signaling and directional root growth.	brassinolide	0-12	Auxin efflux carrier family protein	Arabidopsis thaliana	114-118
31797871-6	2019	Strikingly, simulations indicate that PIN2 gradient formation is no prerequisite for root bending but rather dampens asymmetric auxin flow and signaling.	Indoleacetic Acids	128-133	Auxin efflux carrier family protein	Arabidopsis thaliana	38-42
31318449-9	2019	PtdIns(4,5)P2 -dependent endocytosis of FM 4-64, PIN2 and the NADPH-oxidase RbohD were reduced upon flg22 treatment or MKK5 induction.	Phosphatidylinositol 4,5-Diphosphate	0-13	Auxin efflux carrier family protein	Arabidopsis thaliana	49-53
33404549-0	2020	PIN FORMED 2 Modulates the Transport of Arsenite in Arabidopsis thaliana.	arsenite	40-48	Auxin efflux carrier family protein	Arabidopsis thaliana	0-12
33404549-5	2020	Using molecular physiology, synchrotron imaging, and root transport assay approaches, we show that the cellular transport of trivalent arsenicals in Arabidopsis thaliana is strongly modulated by PIN FORMED 2 (PIN2) auxin efflux transporter.	Arsenicals	135-145	Auxin efflux carrier family protein	Arabidopsis thaliana	195-207
33404549-5	2020	Using molecular physiology, synchrotron imaging, and root transport assay approaches, we show that the cellular transport of trivalent arsenicals in Arabidopsis thaliana is strongly modulated by PIN FORMED 2 (PIN2) auxin efflux transporter.	Arsenicals	135-145	Auxin efflux carrier family protein	Arabidopsis thaliana	209-213
33404549-6	2020	Root transport assay using radioactive arsenite, X-ray fluorescence imaging (XFI) coupled with X-ray absorption spectroscopy (XAS), and inductively coupled plasma mass spectrometry analysis revealed that pin2 plants accumulate higher concentrations of arsenite in roots compared with the wild-type.	arsenite	39-47	Auxin efflux carrier family protein	Arabidopsis thaliana	204-208
33404549-6	2020	Root transport assay using radioactive arsenite, X-ray fluorescence imaging (XFI) coupled with X-ray absorption spectroscopy (XAS), and inductively coupled plasma mass spectrometry analysis revealed that pin2 plants accumulate higher concentrations of arsenite in roots compared with the wild-type.	arsenite	252-260	Auxin efflux carrier family protein	Arabidopsis thaliana	204-208
33404549-7	2020	At the cellular level, arsenite specifically targets intracellular sorting of PIN2 and thereby alters the cellular auxin homeostasis.	arsenite	23-31	Auxin efflux carrier family protein	Arabidopsis thaliana	78-82
33404549-8	2020	Consistently, loss of PIN2 function results in arsenite hypersensitivity in roots.	arsenite	47-55	Auxin efflux carrier family protein	Arabidopsis thaliana	22-26
33404549-9	2020	XFI coupled with XAS further revealed that loss of PIN2 function results in specific accumulation of arsenical species, but not the other metals such as iron, zinc, or calcium in the root tip.	Iron	153-157	Auxin efflux carrier family protein	Arabidopsis thaliana	51-55
31318449-9	2019	PtdIns(4,5)P2 -dependent endocytosis of FM 4-64, PIN2 and the NADPH-oxidase RbohD were reduced upon flg22 treatment or MKK5 induction.	flg22	100-105	Auxin efflux carrier family protein	Arabidopsis thaliana	49-53
29893960-5	2018	An increase in auxin level in the root tips was associated with increased expression of auxin biosynthesis genes and auxin polar transporter AUX1 and PIN2 genes under BA stress.	Benzoic Acid	167-169	Auxin efflux carrier family protein	Arabidopsis thaliana	150-154
30668780-0	2019	Root Adaptation to H2O2-Induced Oxidative Stress by ARF-GEF BEN1- and Cytoskeleton-Mediated PIN2 Trafficking.	Hydrogen Peroxide	19-23	Auxin efflux carrier family protein	Arabidopsis thaliana	92-96
30668780-5	2019	Specifically, increase in H2O2 levels affects PIN2 endocytic recycling.	Hydrogen Peroxide	26-30	Auxin efflux carrier family protein	Arabidopsis thaliana	46-50
30668780-7	2019	We propose that H2O2 levels affect the actin dynamics thus modulating ARF-GEF-dependent trafficking of PIN2.	Hydrogen Peroxide	16-20	Auxin efflux carrier family protein	Arabidopsis thaliana	103-107
30464035-4	2019	Here, we reveal that, in Arabidopsis (Arabidopsis thaliana), the phosphatidic acid (PA)-regulated PINOID (PID) kinase is a crucial modulator of PIN2 activity and auxin redistribution in response to salt stress.	Phosphatidic Acids	65-82	Auxin efflux carrier family protein	Arabidopsis thaliana	144-148
30464035-4	2019	Here, we reveal that, in Arabidopsis (Arabidopsis thaliana), the phosphatidic acid (PA)-regulated PINOID (PID) kinase is a crucial modulator of PIN2 activity and auxin redistribution in response to salt stress.	Phosphatidic Acids	84-86	Auxin efflux carrier family protein	Arabidopsis thaliana	144-148
30464035-6	2019	The phospholipase D-derived PA interacted with PID and increased PID-dependent phosphorylation of PIN2, which activated auxin efflux and altered auxin accumulation, promoting root growth when exposed to salt stress.	Phosphatidic Acids	28-30	Auxin efflux carrier family protein	Arabidopsis thaliana	98-102
30464035-6	2019	The phospholipase D-derived PA interacted with PID and increased PID-dependent phosphorylation of PIN2, which activated auxin efflux and altered auxin accumulation, promoting root growth when exposed to salt stress.	Indoleacetic Acids	120-125	Auxin efflux carrier family protein	Arabidopsis thaliana	98-102
30464035-7	2019	Ablation of the PA binding motif not only diminished PID accumulation at the plasma membrane but also abolished PA-promoted PID phosphorylation of PIN2 and its function in coping with salt stress; however, this ablation did not affect inflorescence and cotyledon development or PIN2-dependent gravitropic and halotropic responses.	Phosphatidic Acids	16-18	Auxin efflux carrier family protein	Arabidopsis thaliana	147-151
30464035-7	2019	Ablation of the PA binding motif not only diminished PID accumulation at the plasma membrane but also abolished PA-promoted PID phosphorylation of PIN2 and its function in coping with salt stress; however, this ablation did not affect inflorescence and cotyledon development or PIN2-dependent gravitropic and halotropic responses.	Phosphatidic Acids	16-18	Auxin efflux carrier family protein	Arabidopsis thaliana	278-282
30275058-6	2018	Similar to ethylene, exogenous PABA reverses the agravitropic root growth of the auxin transport mutant pin-formed2 (pin2) and the auxin biosynthetic double mutant with loss of function of weak ethylene insensitive (wei) genes, wei8wei2, but not the pin2wei8wei2 triple mutant.	4-Aminobenzoic Acid	31-35	Auxin efflux carrier family protein	Arabidopsis thaliana	104-115
30275058-6	2018	Similar to ethylene, exogenous PABA reverses the agravitropic root growth of the auxin transport mutant pin-formed2 (pin2) and the auxin biosynthetic double mutant with loss of function of weak ethylene insensitive (wei) genes, wei8wei2, but not the pin2wei8wei2 triple mutant.	4-Aminobenzoic Acid	31-35	Auxin efflux carrier family protein	Arabidopsis thaliana	117-121
30333147-2	2018	Ethylene-inhibited root elongation involves PIN-FORMED2 (PIN2)-mediated basipetal auxin transport, but the molecular mechanisms underlying the regulation of PIN2 function by ethylene (and therefore auxin distribution) are poorly understood.	ethylene	0-8	Auxin efflux carrier family protein	Arabidopsis thaliana	44-55
30333147-2	2018	Ethylene-inhibited root elongation involves PIN-FORMED2 (PIN2)-mediated basipetal auxin transport, but the molecular mechanisms underlying the regulation of PIN2 function by ethylene (and therefore auxin distribution) are poorly understood.	ethylene	0-8	Auxin efflux carrier family protein	Arabidopsis thaliana	57-61
30333147-2	2018	Ethylene-inhibited root elongation involves PIN-FORMED2 (PIN2)-mediated basipetal auxin transport, but the molecular mechanisms underlying the regulation of PIN2 function by ethylene (and therefore auxin distribution) are poorly understood.	ethylene	0-8	Auxin efflux carrier family protein	Arabidopsis thaliana	157-161
30333147-2	2018	Ethylene-inhibited root elongation involves PIN-FORMED2 (PIN2)-mediated basipetal auxin transport, but the molecular mechanisms underlying the regulation of PIN2 function by ethylene (and therefore auxin distribution) are poorly understood.	ethylene	174-182	Auxin efflux carrier family protein	Arabidopsis thaliana	157-161
30080609-8	2018	Auxin response in root tip cells is altered and there is a severe disruption in polar localization of PIN1-GFP, but to a less extent of PIN2-GFP in the root tips, which causes the apical meristematic organization defects and might also be responsible for the secretion of sporopollenin precursor or polar targeting of sporopollenin precursor transporters.	sporopollenin	272-285	Auxin efflux carrier family protein	Arabidopsis thaliana	136-140
31105724-8	2019	NaCl treatment greatly suppressed the expression levels of ProPIN1:PIN1-GFP, ProPIN2:PIN2-GFP, ProPIN3:PIN3-GFP, and ProDR5:GFP, and suppressed root meristem activity in iar4.	Sodium Chloride	0-4	Auxin efflux carrier family protein	Arabidopsis thaliana	80-84
30464035-7	2019	Ablation of the PA binding motif not only diminished PID accumulation at the plasma membrane but also abolished PA-promoted PID phosphorylation of PIN2 and its function in coping with salt stress; however, this ablation did not affect inflorescence and cotyledon development or PIN2-dependent gravitropic and halotropic responses.	Phosphatidic Acids	112-114	Auxin efflux carrier family protein	Arabidopsis thaliana	147-151
30464035-7	2019	Ablation of the PA binding motif not only diminished PID accumulation at the plasma membrane but also abolished PA-promoted PID phosphorylation of PIN2 and its function in coping with salt stress; however, this ablation did not affect inflorescence and cotyledon development or PIN2-dependent gravitropic and halotropic responses.	Phosphatidic Acids	112-114	Auxin efflux carrier family protein	Arabidopsis thaliana	278-282
30464035-8	2019	Our data indicate a role for PA in coupling extracellular salt signaling to PID-directed PIN2 phosphorylation and polar auxin transport, highlighting the importance of lipid-protein interactions in the spatiotemporal regulation of auxin signaling.	Phosphatidic Acids	29-31	Auxin efflux carrier family protein	Arabidopsis thaliana	89-93
30464035-8	2019	Our data indicate a role for PA in coupling extracellular salt signaling to PID-directed PIN2 phosphorylation and polar auxin transport, highlighting the importance of lipid-protein interactions in the spatiotemporal regulation of auxin signaling.	Salts	58-62	Auxin efflux carrier family protein	Arabidopsis thaliana	89-93
29893960-7	2018	Furthermore, BA stimulated ethylene evolution, whereas blocking BA-induced ethylene signaling with an ethylene biosynthesis inhibitor (Co2+), an ethylene perception antagonist (1-methylcyclopropene) or ethylene signaling mutant lines etr1-3 and ein3eil1 compromised BA-mediated inhibition of root elongation and up-regulation of auxin biosynthesis-related genes together with AUX1 and PIN2, indicating that ethylene signal was involved in auxin-mediated inhibition of primary root elongation during BA stress.	Benzoic Acid	64-66	Auxin efflux carrier family protein	Arabidopsis thaliana	385-389
29893960-7	2018	Furthermore, BA stimulated ethylene evolution, whereas blocking BA-induced ethylene signaling with an ethylene biosynthesis inhibitor (Co2+), an ethylene perception antagonist (1-methylcyclopropene) or ethylene signaling mutant lines etr1-3 and ein3eil1 compromised BA-mediated inhibition of root elongation and up-regulation of auxin biosynthesis-related genes together with AUX1 and PIN2, indicating that ethylene signal was involved in auxin-mediated inhibition of primary root elongation during BA stress.	Benzoic Acid	64-66	Auxin efflux carrier family protein	Arabidopsis thaliana	385-389
29893960-9	2018	Taken together, our results reveal that the allelochemical BA inhibits root elongation by increasing auxin accumulation via stimulation of auxin biosynthesis and AUX1/PIN2-mediated auxin transport via stimulation of ethylene production and an auxin/ethylene-independent ROS burst.	Benzoic Acid	59-61	Auxin efflux carrier family protein	Arabidopsis thaliana	167-171
29893960-9	2018	Taken together, our results reveal that the allelochemical BA inhibits root elongation by increasing auxin accumulation via stimulation of auxin biosynthesis and AUX1/PIN2-mediated auxin transport via stimulation of ethylene production and an auxin/ethylene-independent ROS burst.	ethylene	216-224	Auxin efflux carrier family protein	Arabidopsis thaliana	167-171
29893960-9	2018	Taken together, our results reveal that the allelochemical BA inhibits root elongation by increasing auxin accumulation via stimulation of auxin biosynthesis and AUX1/PIN2-mediated auxin transport via stimulation of ethylene production and an auxin/ethylene-independent ROS burst.	ethylene	249-257	Auxin efflux carrier family protein	Arabidopsis thaliana	167-171
29893960-9	2018	Taken together, our results reveal that the allelochemical BA inhibits root elongation by increasing auxin accumulation via stimulation of auxin biosynthesis and AUX1/PIN2-mediated auxin transport via stimulation of ethylene production and an auxin/ethylene-independent ROS burst.	Reactive Oxygen Species	270-273	Auxin efflux carrier family protein	Arabidopsis thaliana	167-171
29893960-6	2018	Mutant analyses demonstrated that AUX1 and PIN2 rather than PIN1 were required for the inhibition of primary root elongation during BA exposure.	Benzoic Acid	132-134	Auxin efflux carrier family protein	Arabidopsis thaliana	43-47
29893960-7	2018	Furthermore, BA stimulated ethylene evolution, whereas blocking BA-induced ethylene signaling with an ethylene biosynthesis inhibitor (Co2+), an ethylene perception antagonist (1-methylcyclopropene) or ethylene signaling mutant lines etr1-3 and ein3eil1 compromised BA-mediated inhibition of root elongation and up-regulation of auxin biosynthesis-related genes together with AUX1 and PIN2, indicating that ethylene signal was involved in auxin-mediated inhibition of primary root elongation during BA stress.	Benzoic Acid	64-66	Auxin efflux carrier family protein	Arabidopsis thaliana	385-389
29669031-2	2018	With Mg deficiency, both ethylene and NO promoted the elevation of root auxin levels in roots by inducing the expression of AUXIN-RESISTANT1 (AUX1), PIN-FORMED 1 (PIN1) and PIN2 transporters.	ethylene	25-33	Auxin efflux carrier family protein	Arabidopsis thaliana	173-177
29599797-8	2018	By evaluating internalization of PIN2, PG was shown to regulate endocytosis process coordinately with NAA.	Phosphatidylglycerols	39-41	Auxin efflux carrier family protein	Arabidopsis thaliana	33-37
29775864-8	2018	Furthermore, the normally polar localization of Pin-formed 1 (PIN1) and PIN2 became uniformly distributed on root tip cell membranes after treatment with H2O2.	Hydrogen Peroxide	154-158	Auxin efflux carrier family protein	Arabidopsis thaliana	72-76
29218054-0	2017	Excessive Cellular S-nitrosothiol Impairs Endocytosis of Auxin Efflux Transporter PIN2.	S-Nitrosothiols	19-33	Auxin efflux carrier family protein	Arabidopsis thaliana	82-86
29218054-7	2017	The internalization of PM-associated PIN2 or PIN2-GFP into Brefeldin A (BFA) bodies was significantly reduced in gsnor1-3 upon BFA treatment in a manner independent of de novo protein synthesis.	Brefeldin A	59-70	Auxin efflux carrier family protein	Arabidopsis thaliana	45-49
29218054-7	2017	The internalization of PM-associated PIN2 or PIN2-GFP into Brefeldin A (BFA) bodies was significantly reduced in gsnor1-3 upon BFA treatment in a manner independent of de novo protein synthesis.	Brefeldin A	72-75	Auxin efflux carrier family protein	Arabidopsis thaliana	37-41
29218054-7	2017	The internalization of PM-associated PIN2 or PIN2-GFP into Brefeldin A (BFA) bodies was significantly reduced in gsnor1-3 upon BFA treatment in a manner independent of de novo protein synthesis.	Brefeldin A	59-70	Auxin efflux carrier family protein	Arabidopsis thaliana	37-41
29218054-7	2017	The internalization of PM-associated PIN2 or PIN2-GFP into Brefeldin A (BFA) bodies was significantly reduced in gsnor1-3 upon BFA treatment in a manner independent of de novo protein synthesis.	Brefeldin A	72-75	Auxin efflux carrier family protein	Arabidopsis thaliana	45-49
29218054-7	2017	The internalization of PM-associated PIN2 or PIN2-GFP into Brefeldin A (BFA) bodies was significantly reduced in gsnor1-3 upon BFA treatment in a manner independent of de novo protein synthesis.	Brefeldin A	127-130	Auxin efflux carrier family protein	Arabidopsis thaliana	37-41
29218054-7	2017	The internalization of PM-associated PIN2 or PIN2-GFP into Brefeldin A (BFA) bodies was significantly reduced in gsnor1-3 upon BFA treatment in a manner independent of de novo protein synthesis.	Brefeldin A	127-130	Auxin efflux carrier family protein	Arabidopsis thaliana	45-49
28890725-5	2017	In the case of the stimulatory effect of low ABA concentrations, it was blocked by two different auxin efflux inhibitors and was less pronounced in an auxin efflux mutant (pin2/eir1-1) and in the iaa7/axr2-1 auxin-insensitive mutant.	Abscisic Acid	45-48	Auxin efflux carrier family protein	Arabidopsis thaliana	172-176
29218054-8	2017	In addition, the exogenously applied GSNO not only compromised the endocytosis of PIN2-GFP but also inhibited the root elongation in a concentration-dependent manner.	S-Nitrosoglutathione	37-41	Auxin efflux carrier family protein	Arabidopsis thaliana	82-86
29109378-5	2017	PIN2 sequence alignments and modeling predictions indicated that both cysteines are facing the cytoplasm and therefore would be accessible to redox status-controlled modifications.	Cysteine	70-79	Auxin efflux carrier family protein	Arabidopsis thaliana	0-4
29109378-7	2017	The observed effects of cysteine replacements on root growth and PIN2 localization are consistent with a model in which redox status-dependent cysteine modifications participate in the regulation of PIN2 mobility, thereby fine-tuning polar auxin transport.	Cysteine	24-32	Auxin efflux carrier family protein	Arabidopsis thaliana	65-69
29109378-7	2017	The observed effects of cysteine replacements on root growth and PIN2 localization are consistent with a model in which redox status-dependent cysteine modifications participate in the regulation of PIN2 mobility, thereby fine-tuning polar auxin transport.	Cysteine	24-32	Auxin efflux carrier family protein	Arabidopsis thaliana	199-203
29109378-7	2017	The observed effects of cysteine replacements on root growth and PIN2 localization are consistent with a model in which redox status-dependent cysteine modifications participate in the regulation of PIN2 mobility, thereby fine-tuning polar auxin transport.	Cysteine	143-151	Auxin efflux carrier family protein	Arabidopsis thaliana	199-203
28919907-0	2017	Heterotrimeric G Protein-Regulated Ca2+ Influx and PIN2 Asymmetric Distribution Are Involved in Arabidopsis thaliana Roots" Avoidance Response to Extracellular ATP.	Adenosine Triphosphate	160-163	Auxin efflux carrier family protein	Arabidopsis thaliana	51-55
28919907-7	2017	DR5-GFP and PIN2 were asymmetrically distributed in ATP-stimulated root tips, this effect was strongly suppressed by EGTA and diminished in Galpha null mutants.	Adenosine Triphosphate	52-55	Auxin efflux carrier family protein	Arabidopsis thaliana	12-16
28919907-7	2017	DR5-GFP and PIN2 were asymmetrically distributed in ATP-stimulated root tips, this effect was strongly suppressed by EGTA and diminished in Galpha null mutants.	Egtazic Acid	117-121	Auxin efflux carrier family protein	Arabidopsis thaliana	12-16
28698357-2	2017	Here, we show that Arabidopsis (Arabidopsis thaliana) RopGEF1, a guanine nucleotide exchange factor and activator of Rho GTPases of plants (ROPs), is critically involved in polar distribution of auxin influx carrier AUX1 and differential accumulation of efflux carriers PIN7 and PIN2 and is important for embryo and early seedling development when RopGEF1 is prevalently expressed.	Guanine Nucleotides	65-83	Auxin efflux carrier family protein	Arabidopsis thaliana	279-283
28890725-5	2017	In the case of the stimulatory effect of low ABA concentrations, it was blocked by two different auxin efflux inhibitors and was less pronounced in an auxin efflux mutant (pin2/eir1-1) and in the iaa7/axr2-1 auxin-insensitive mutant.	Abscisic Acid	45-48	Auxin efflux carrier family protein	Arabidopsis thaliana	177-183
28890725-6	2017	Thus it appears that the stimulatory effect seen at low ABA concentrations is via an ethylene-independent pathway requiring auxin signalling and auxin efflux through PIN2/EIR1, while the inhibitory effect at high ABA concentrations is via an ethylene-dependent pathway requiring auxin signalling and auxin influx through AUX1.	Abscisic Acid	56-59	Auxin efflux carrier family protein	Arabidopsis thaliana	166-170
28890725-6	2017	Thus it appears that the stimulatory effect seen at low ABA concentrations is via an ethylene-independent pathway requiring auxin signalling and auxin efflux through PIN2/EIR1, while the inhibitory effect at high ABA concentrations is via an ethylene-dependent pathway requiring auxin signalling and auxin influx through AUX1.	Abscisic Acid	56-59	Auxin efflux carrier family protein	Arabidopsis thaliana	171-175
28890725-6	2017	Thus it appears that the stimulatory effect seen at low ABA concentrations is via an ethylene-independent pathway requiring auxin signalling and auxin efflux through PIN2/EIR1, while the inhibitory effect at high ABA concentrations is via an ethylene-dependent pathway requiring auxin signalling and auxin influx through AUX1.	ethylene	85-93	Auxin efflux carrier family protein	Arabidopsis thaliana	166-170
28890725-6	2017	Thus it appears that the stimulatory effect seen at low ABA concentrations is via an ethylene-independent pathway requiring auxin signalling and auxin efflux through PIN2/EIR1, while the inhibitory effect at high ABA concentrations is via an ethylene-dependent pathway requiring auxin signalling and auxin influx through AUX1.	ethylene	85-93	Auxin efflux carrier family protein	Arabidopsis thaliana	171-175
28165500-6	2017	In the rol1-2 mutant, PIN2 shows a flavonol-induced basal-to-apical shift in polar localization which is reversed in the rol1-2 rcn1-3 to basal localization.	3-hydroxyflavone	35-43	Auxin efflux carrier family protein	Arabidopsis thaliana	22-26
27681606-0	2016	Enrichment of hydroxylated C24- and C26-acyl-chain sphingolipids mediates PIN2 apical sorting at trans-Golgi network subdomains.	Sphingolipids	51-64	Auxin efflux carrier family protein	Arabidopsis thaliana	74-78
28165500-0	2017	Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity.	3-hydroxyflavone	0-8	Auxin efflux carrier family protein	Arabidopsis thaliana	28-32
27681606-3	2016	Here we demonstrate that sphingolipids with alpha-hydroxylated acyl-chains of at least 24 carbon atoms are enriched in secretory vesicle subdomains of the TGN and are critical for de novo polar secretory sorting of the auxin carrier PIN2 to apical membrane of Arabidopsis root epithelial cells.	Sphingolipids	25-38	Auxin efflux carrier family protein	Arabidopsis thaliana	233-237
27681606-3	2016	Here we demonstrate that sphingolipids with alpha-hydroxylated acyl-chains of at least 24 carbon atoms are enriched in secretory vesicle subdomains of the TGN and are critical for de novo polar secretory sorting of the auxin carrier PIN2 to apical membrane of Arabidopsis root epithelial cells.	Carbon	90-96	Auxin efflux carrier family protein	Arabidopsis thaliana	233-237
27681606-5	2016	Our results uncover that the sphingolipids acyl-chain length links lipid composition of TGN subdomains with polar secretory trafficking of PIN2 to apical membrane of polarized epithelial cells.	Sphingolipids	29-42	Auxin efflux carrier family protein	Arabidopsis thaliana	139-143
27510970-6	2016	Our model points to the key role of root tip architecture in allowing the decrease in PIN2 at the salt-exposed side of the root to result in a re-routing of auxin to the opposite side.	Salts	98-102	Auxin efflux carrier family protein	Arabidopsis thaliana	86-90
27506239-2	2016	All compounds, except Indole-3-butyric acid, repressed the recovery of the PIN2-Dendra2 plasma membrane pool after photoconversion when they were used in high concentrations.	indolebutyric acid	22-43	Auxin efflux carrier family protein	Arabidopsis thaliana	75-79
27506239-4	2016	Auxins and auxin transport inhibitors suppressed also the accumulation of both newly synthesized and endocytotic PIN2 pools in Brefeldin A compartments (BFACs).	bfacs	153-158	Auxin efflux carrier family protein	Arabidopsis thaliana	113-117
27506239-8	2016	The study also confirmed inappropriateness of the BFA-based approach to study PIN2 endocytosis because the majority of PIN2 accumulating in BFACs is newly synthesized and not derived from the plasma membrane.	bfacs	140-145	Auxin efflux carrier family protein	Arabidopsis thaliana	119-123
25609825-0	2015	Arabidopsis response to low-phosphate conditions includes active changes in actin filaments and PIN2 polarization and is dependent on strigolactone signalling.	Phosphates	28-37	Auxin efflux carrier family protein	Arabidopsis thaliana	96-100
26232920-9	2015	Furthermore, pharmacological analysis indicated that the brefeldin A (BFA)-insensitive pathway is employed in the cellular effects of NCS on PIN2 trafficking.	Brefeldin A	70-73	Auxin efflux carrier family protein	Arabidopsis thaliana	141-145
26468517-8	2015	Our findings demonstrate the relationship between excess Fe-dependent PIN2 expression and LR formation and the potential role of AUX1 in ethylene-mediated LR tolerance and suggest that AUX1 and PIN2 protect LR formation in Arabidopsis during the early stages of Fe stress.	Iron	57-59	Auxin efflux carrier family protein	Arabidopsis thaliana	70-74
26468517-8	2015	Our findings demonstrate the relationship between excess Fe-dependent PIN2 expression and LR formation and the potential role of AUX1 in ethylene-mediated LR tolerance and suggest that AUX1 and PIN2 protect LR formation in Arabidopsis during the early stages of Fe stress.	Iron	57-59	Auxin efflux carrier family protein	Arabidopsis thaliana	194-198
25922494-5	2015	The altered root growth in response to P and Mg supply was correlated with AUX1, PIN2, and PIN3 mRNA abundance and expression and the accumulation of the protein.	Phosphorus	39-40	Auxin efflux carrier family protein	Arabidopsis thaliana	81-85
25922494-5	2015	The altered root growth in response to P and Mg supply was correlated with AUX1, PIN2, and PIN3 mRNA abundance and expression and the accumulation of the protein.	Magnesium	45-47	Auxin efflux carrier family protein	Arabidopsis thaliana	81-85
25690466-6	2015	Genetic and pharmacological analyses showed that SA-induced root waving involved an AtNOA1-dependent Ca(2+) signal transduction pathway, and PIN-FORMED2 (PIN2) -based polar auxin transport possibly plays a crucial role in this process.	Salicylic Acid	49-51	Auxin efflux carrier family protein	Arabidopsis thaliana	154-158
27068826-6	2016	An enhanced level of PIN2-LPs observed in the central cell walls separating two asynchronously developing parts of antheridial filaments (characterized by the plugged plasmodesmata) is correlated with an enhanced deposition of callose.	callose	227-234	Auxin efflux carrier family protein	Arabidopsis thaliana	21-25
27242830-8	2016	We further determined that excess ROS accumulation caused by methyl viologen treatment or decreased glutathione levels caused by buthionine sulfoximine treatment can decrease the levels of auxin efflux proteins such as PIN2-4.	Reactive Oxygen Species	34-37	Auxin efflux carrier family protein	Arabidopsis thaliana	219-225
27242830-8	2016	We further determined that excess ROS accumulation caused by methyl viologen treatment or decreased glutathione levels caused by buthionine sulfoximine treatment can decrease the levels of auxin efflux proteins such as PIN2-4.	Glutathione	100-111	Auxin efflux carrier family protein	Arabidopsis thaliana	219-225
27242830-8	2016	We further determined that excess ROS accumulation caused by methyl viologen treatment or decreased glutathione levels caused by buthionine sulfoximine treatment can decrease the levels of auxin efflux proteins such as PIN2-4.	Buthionine Sulfoximine	129-151	Auxin efflux carrier family protein	Arabidopsis thaliana	219-225
26468517-0	2015	Auxin Resistant1 and PIN-FORMED2 Protect Lateral Root Formation in Arabidopsis under Iron Stress.	Iron	85-89	Auxin efflux carrier family protein	Arabidopsis thaliana	21-32
26468517-4	2015	Furthermore, Fe stress significantly reduced PIN-FORMED2 (PIN2)-green fluorescent protein (GFP) expression in root tips, and pin2-1 mutants exhibited significantly fewer LR initiation events under excess Fe than the wild type.	Iron	13-15	Auxin efflux carrier family protein	Arabidopsis thaliana	45-56
26468517-4	2015	Furthermore, Fe stress significantly reduced PIN-FORMED2 (PIN2)-green fluorescent protein (GFP) expression in root tips, and pin2-1 mutants exhibited significantly fewer LR initiation events under excess Fe than the wild type.	Iron	13-15	Auxin efflux carrier family protein	Arabidopsis thaliana	58-62
26468517-4	2015	Furthermore, Fe stress significantly reduced PIN-FORMED2 (PIN2)-green fluorescent protein (GFP) expression in root tips, and pin2-1 mutants exhibited significantly fewer LR initiation events under excess Fe than the wild type.	Iron	204-206	Auxin efflux carrier family protein	Arabidopsis thaliana	125-129
26468517-5	2015	Exogenous application of both Fe and glutathione together increased PIN2-GFP expression and the number of LR initiation events compared with Fe treatment alone.	Iron	30-32	Auxin efflux carrier family protein	Arabidopsis thaliana	68-72
26468517-5	2015	Exogenous application of both Fe and glutathione together increased PIN2-GFP expression and the number of LR initiation events compared with Fe treatment alone.	Glutathione	37-48	Auxin efflux carrier family protein	Arabidopsis thaliana	68-72
24654932-3	2014	Short-term TE1 treatment causes accumulation of PM proteins, including the BR (brassinosteroid) receptor BRI1 (BR insensitive 1), PIP2a (PM intrinsic protein 2a) and the auxin transporter PIN2 (PIN-FORMED 2) in a PVC (pre-vacuolar related compartment), which is sensitive to BFA (Brefeldin A).	Brefeldin A	275-278	Auxin efflux carrier family protein	Arabidopsis thaliana	194-206
24798139-4	2015	Elevating cellular L-cysteine level by exposing Arabidopsis thaliana seedlings to high L-cysteine, buthionine sulphoximine, or O-acetylserine leads to altered auxin maximum in root tips, the expression of quiescent center cell marker as well as the decrease of the auxin carriers PIN1, PIN2, PIN3, and PIN7 of primary roots.	Cysteine	19-29	Auxin efflux carrier family protein	Arabidopsis thaliana	286-290
26313814-1	2015	Tungsten, supplied as sodium tungstate, inhibits root elongation in Arabidopsis thaliana, which has been attributed to a diminishing of PIN2 and PIN3 auxin efflux carriers.	Tungsten	0-8	Auxin efflux carrier family protein	Arabidopsis thaliana	136-140
26313814-1	2015	Tungsten, supplied as sodium tungstate, inhibits root elongation in Arabidopsis thaliana, which has been attributed to a diminishing of PIN2 and PIN3 auxin efflux carriers.	sodium tungstate(VI)	22-38	Auxin efflux carrier family protein	Arabidopsis thaliana	136-140
26252364-0	2015	The effect of indole-3-carbinol on PIN1 and PIN2 in Arabidopsis roots.	indole-3-carbinol	14-31	Auxin efflux carrier family protein	Arabidopsis thaliana	44-48
26252364-4	2015	Brief treatment with indole-3-carbinol led to a reduction in the amount of PIN1 and to mislocalization of PIN2.	indole-3-carbinol	21-38	Auxin efflux carrier family protein	Arabidopsis thaliana	106-110
24571327-0	2014	Strigolactone analog GR24 triggers changes in PIN2 polarity, vesicle trafficking and actin filament architecture.	GR24 strigolactone	0-13	Auxin efflux carrier family protein	Arabidopsis thaliana	46-50
23673979-9	2013	CRK5 phosphorylates the hydrophilic loop of PIN2 in vitro, and PIN2 shows accelerated accumulation in brefeldin bodies in the crk5 mutant.	brefeldin bodies	102-118	Auxin efflux carrier family protein	Arabidopsis thaliana	44-48
24274232-9	2013	However, the mutant PIN2 protein levels were restored by wortmannin treatment almost to the wild-type PIN2 level, indicating that the M3 motif of PIN2, unlike that of other PINs, is implicated in PIN2 trafficking to the vacuolar lytic pathway.	Wortmannin	57-67	Auxin efflux carrier family protein	Arabidopsis thaliana	20-24
23683587-9	2013	Additionally, there was less promotion of LR formation by Cd treatment in aux1-7 and pin2 mutants than that in the WT.	Cadmium	58-60	Auxin efflux carrier family protein	Arabidopsis thaliana	85-89
24326589-6	2013	Furthermore, fewer brefeldin A-induced endosomal bodies decorated by PIN1-GFP or PIN2-GFP formed in pip5k1 pip5k2 mutants.	Brefeldin A	19-30	Auxin efflux carrier family protein	Arabidopsis thaliana	81-85
24094855-5	2013	We show that salt-induced phospholipase D activity stimulates clathrin-mediated endocytosis of PIN2 at the side of the root facing the higher salt concentration.	Salts	13-17	Auxin efflux carrier family protein	Arabidopsis thaliana	95-99
24094855-5	2013	We show that salt-induced phospholipase D activity stimulates clathrin-mediated endocytosis of PIN2 at the side of the root facing the higher salt concentration.	Salts	142-146	Auxin efflux carrier family protein	Arabidopsis thaliana	95-99
24094855-6	2013	The intracellular relocalization of PIN2 allows for auxin redistribution and for the directional bending of the root away from the higher salt concentration.	Salts	138-142	Auxin efflux carrier family protein	Arabidopsis thaliana	36-40
23733053-7	2013	Moreover, pin2 was insensitive for cGMP and H2O2 suggesting that PIN2 protein plays an important role in cGMP and H2O2 modulating the lateral root development of Arabidopsis.	Cyclic GMP	105-109	Auxin efflux carrier family protein	Arabidopsis thaliana	65-69
23733053-7	2013	Moreover, pin2 was insensitive for cGMP and H2O2 suggesting that PIN2 protein plays an important role in cGMP and H2O2 modulating the lateral root development of Arabidopsis.	Hydrogen Peroxide	114-118	Auxin efflux carrier family protein	Arabidopsis thaliana	65-69
23500713-8	2013	We further find that 8-Br-cGMP and Ly83583 change the expression of auxin transport genes and alter the polar localization and expression of PIN1 and PIN2 proteins.	8-bromocyclic GMP	21-30	Auxin efflux carrier family protein	Arabidopsis thaliana	150-154
23673979-9	2013	CRK5 phosphorylates the hydrophilic loop of PIN2 in vitro, and PIN2 shows accelerated accumulation in brefeldin bodies in the crk5 mutant.	brefeldin bodies	102-118	Auxin efflux carrier family protein	Arabidopsis thaliana	63-67
23500713-8	2013	We further find that 8-Br-cGMP and Ly83583 change the expression of auxin transport genes and alter the polar localization and expression of PIN1 and PIN2 proteins.	6-anilino-5,8-quinolinedione	35-42	Auxin efflux carrier family protein	Arabidopsis thaliana	150-154
23577016-4	2013	In ethylene hypersignaling mutants such as polaris (pls), we show experimentally that expression of both PIN1 and PIN2 significantly increases.	ethylene	3-11	Auxin efflux carrier family protein	Arabidopsis thaliana	114-118
23577016-7	2013	Network construction reveals that the regulation of both PIN1 and PIN2 is predominantly via ethylene signaling.	ethylene	92-100	Auxin efflux carrier family protein	Arabidopsis thaliana	66-70