PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
15539473-9	2004	We propose a new model for iron uptake in Arabidopsis where FRO2 and IRT1 are differentially regulated by FIT1.	Iron	27-31	ferric reduction oxidase 2	Arabidopsis thaliana	60-64
15556641-5	2004	FRU mutant plants were chlorotic, and the FRU gene was found necessary for induction of the essential iron mobilization genes FRO2 (ferric chelate reductase gene) and IRT1 (iron-regulated transporter gene).	Iron	102-106	ferric reduction oxidase 2	Arabidopsis thaliana	126-130
14675444-10	2003	Sequences homologous to IDE1 were also found in many other Fe-deficiency-inducible promoters, including: nicotianamine aminotransferase (HvNAAT)-A, HvNAAT-B, nicotianamine synthase (HvNAS1), HvIDS3, OsNAS1, OsNAS2, OsIRT1, AtIRT1, and AtFRO2, suggesting the conservation of cis-acting elements in various genes and species.	Iron	59-61	ferric reduction oxidase 2	Arabidopsis thaliana	235-241
12787249-12	2003	To account for the results presented, we propose that AtNRAMP3 influences metal accumulation and IRT1 and FRO2 gene expression by mobilizing vacuolar metal pools to the cytosol.	Metals	150-155	ferric reduction oxidase 2	Arabidopsis thaliana	106-110
14526117-0	2003	Overexpression of the FRO2 ferric chelate reductase confers tolerance to growth on low iron and uncovers posttranscriptional control.	Iron	87-91	ferric reduction oxidase 2	Arabidopsis thaliana	22-26
14526117-1	2003	The Arabidopsis FRO2 gene encodes the low-iron-inducible ferric chelate reductase responsible for reduction of iron at the root surface.	Iron	42-46	ferric reduction oxidase 2	Arabidopsis thaliana	16-20
14526117-1	2003	The Arabidopsis FRO2 gene encodes the low-iron-inducible ferric chelate reductase responsible for reduction of iron at the root surface.	Iron	111-115	ferric reduction oxidase 2	Arabidopsis thaliana	16-20
14526117-2	2003	Here, we report that FRO2 and IRT1, the major transporter responsible for high-affinity iron uptake from the soil, are coordinately regulated at both the transcriptional and posttranscriptional levels.	Iron	88-92	ferric reduction oxidase 2	Arabidopsis thaliana	21-25
14526117-3	2003	FRO2 and IRT1 are induced together following the imposition of iron starvation and are coordinately repressed following iron resupply.	Iron	63-67	ferric reduction oxidase 2	Arabidopsis thaliana	0-4
14526117-3	2003	FRO2 and IRT1 are induced together following the imposition of iron starvation and are coordinately repressed following iron resupply.	Iron	120-124	ferric reduction oxidase 2	Arabidopsis thaliana	0-4
14526117-4	2003	Steady-state mRNA levels of FRO2 and IRT1 are also coordinately regulated by zinc and cadmium.	Cadmium	86-93	ferric reduction oxidase 2	Arabidopsis thaliana	28-32
14526117-5	2003	Like IRT1, FRO2 mRNA is detected in the epidermal cells of roots, consistent with its proposed role in iron uptake from the soil.	Iron	103-107	ferric reduction oxidase 2	Arabidopsis thaliana	11-15
14526117-8	2003	Finally, the 35S-FRO2 plants grow better on low iron as compared with wild-type plants, supporting the idea that reduction of ferric iron to ferrous iron is the rate-limiting step in iron uptake.	Iron	48-52	ferric reduction oxidase 2	Arabidopsis thaliana	17-21
14526117-8	2003	Finally, the 35S-FRO2 plants grow better on low iron as compared with wild-type plants, supporting the idea that reduction of ferric iron to ferrous iron is the rate-limiting step in iron uptake.	ferric sulfate	126-137	ferric reduction oxidase 2	Arabidopsis thaliana	17-21
14526117-8	2003	Finally, the 35S-FRO2 plants grow better on low iron as compared with wild-type plants, supporting the idea that reduction of ferric iron to ferrous iron is the rate-limiting step in iron uptake.	Iron	133-137	ferric reduction oxidase 2	Arabidopsis thaliana	17-21
14526117-8	2003	Finally, the 35S-FRO2 plants grow better on low iron as compared with wild-type plants, supporting the idea that reduction of ferric iron to ferrous iron is the rate-limiting step in iron uptake.	Iron	133-137	ferric reduction oxidase 2	Arabidopsis thaliana	17-21
33568304-3	2021	Previously, we have demonstrated the relationship between the PAP/SAL1 retrograde signaling pathway, the activity of Strategy I Fe uptake genes (FIT, FRO2, IRT1), and ethylene signaling.	Iron	128-130	ferric reduction oxidase 2	Arabidopsis thaliana	150-154
35346040-9	2022	Furthermore, in mnb1 mutants, the transcription level of the Fe uptake- and translocation-related genes, FIT, IRT1, FRO2, ZIF, FRD3, NAS4, PYE and MYB72, were considerably elevated during Fe-deficiency stress, resulting in enhanced Fe uptake and translocation, thereby increasing Fe accumulation.	Iron	61-63	ferric reduction oxidase 2	Arabidopsis thaliana	116-120
35158317-4	2022	Further studies showed that the transcriptional levels of iron-uptake related genes IRT1, FRO2, AHA2, FIT and bHLH38 in mutants were significantly higher than in WT under iron deficiency.	Iron	58-62	ferric reduction oxidase 2	Arabidopsis thaliana	90-94
33188427-7	2021	Mutants opt3 and frd1, which display misregulated Fe homeostasis under Fe sufficient conditions, show disease resistance levels comparable to those of Fe-starved wild-type plants.	Iron	50-52	ferric reduction oxidase 2	Arabidopsis thaliana	17-21
12805609-1	2003	Regulation of the root high-affinity iron uptake system by whole-plant signals was investigated at the molecular level in Arabidopsis, through monitoring FRO2 and IRT1 gene expression.	Iron	37-41	ferric reduction oxidase 2	Arabidopsis thaliana	154-158
12805609-4	2003	Split-root experiments show that the expression of IRT1 and FRO2 is controlled both by a local induction from the root iron pool and through a systemic pathway involving a shoot-borne signal, both signals being integrated to tightly control production of the root iron uptake proteins.	Iron	119-123	ferric reduction oxidase 2	Arabidopsis thaliana	60-64
12805609-4	2003	Split-root experiments show that the expression of IRT1 and FRO2 is controlled both by a local induction from the root iron pool and through a systemic pathway involving a shoot-borne signal, both signals being integrated to tightly control production of the root iron uptake proteins.	Iron	264-268	ferric reduction oxidase 2	Arabidopsis thaliana	60-64
12805609-7	2003	On the basis of the new molecular insights provided in this study and given the strict coregulation of IRT1 and FRO2 observed, we present a model of local and long-distance regulation of the root iron uptake system in Arabidopsis.	Iron	196-200	ferric reduction oxidase 2	Arabidopsis thaliana	112-116
10067892-4	1999	Here we report the isolation of the FRO2 gene, which is expressed in iron-deficient roots of Arabidopsis.	Iron	69-73	ferric reduction oxidase 2	Arabidopsis thaliana	36-40
10067892-10	1999	The isolation of FRO2 has implications for the generation of crops with improved nutritional quality and increased growth in iron-deficient soils.	Iron	125-129	ferric reduction oxidase 2	Arabidopsis thaliana	17-21
8953245-5	1996	frd1 mutants do not translocate radiolabeled iron to the shoots when roots are presented with a tightly chelated form of Fe(III).	ferric sulfate	121-128	ferric reduction oxidase 2	Arabidopsis thaliana	0-4
34340090-3	2021	Knockout of FER in fer-4 mutants downregulated the Cd-induced expression of several genes related to iron (Fe) uptake, including IRT1, bHLH38, NRAMP1, NRAMP3, FRO2 andFIT.	Cadmium	51-53	ferric reduction oxidase 2	Arabidopsis thaliana	159-163
35285505-9	2022	Like overexpression of NAC5, overexpression of NFYA8 increases primary root length, lateral root number, ferric reductase activity, and mRNA abundance of IRT1 and FRO2 under Fe-deficient conditions.	Iron	174-176	ferric reduction oxidase 2	Arabidopsis thaliana	163-167
33568304-3	2021	Previously, we have demonstrated the relationship between the PAP/SAL1 retrograde signaling pathway, the activity of Strategy I Fe uptake genes (FIT, FRO2, IRT1), and ethylene signaling.	ethylene	167-175	ferric reduction oxidase 2	Arabidopsis thaliana	150-154
33573082-8	2021	By contrast, both of them upregulate the Fe acquisition genes FRO2 and IRT1 (and FIT) under Fe deficiency.	Iron	41-43	ferric reduction oxidase 2	Arabidopsis thaliana	62-66
32817691-5	2020	This includes structural genes involved in Fe uptake (i.e. IRT1, FRO2, PDR9, NRAMP1) and transport (i.e. FRD3, NAS4) as well as a subset of their upstream regulators, namely BTS, PYE and the four clade Ib bHLH.	Iron	43-45	ferric reduction oxidase 2	Arabidopsis thaliana	65-69
32873629-5	2020	Interestingly, the AHA2 proton pump and the FRO2 reductase, both of which work in concert with IRT1 in the acidification-reduction-transport strategy of iron uptake, were part of this interactome.	Iron	153-157	ferric reduction oxidase 2	Arabidopsis thaliana	44-48
32873629-7	2020	We characterized the dynamics of the iron uptake complex and showed that FRO2 and AHA2 ubiquitination is independent of the non-iron metal substrates transported by IRT1.	Iron	37-41	ferric reduction oxidase 2	Arabidopsis thaliana	73-77
32351167-7	2020	Here, we extend this investigation by analyzing iron-responsive gene expression of the Fer-like iron deficiency-induced transcription factor (FIT) network (FIT, IRT1, FRO1, and FRO2) and the bHLH transcription factor POPEYE (PYE) network (PYE, ZIF1, FRO3, NAS4, and BTS) in GRXS17 KO plants and wildtype controls grown under iron sufficiency and deficiency conditions.	Iron	48-52	ferric reduction oxidase 2	Arabidopsis thaliana	177-181
28537266-5	2017	These FRO2 allele dependent differences are coupled with altered seedling phenotypes grown on iron-limited soil.	Iron	94-98	ferric reduction oxidase 2	Arabidopsis thaliana	6-10
27792144-7	2016	In addition, the expression of some Fe acquisition-related genes, including FIT1, FRO2, and IRT1 were significantly up-regulated by melatonin treatments, whereas the enhanced expression of these genes was obviously suppressed in the polyamine- and NO-deficient plants.	Iron	36-38	ferric reduction oxidase 2	Arabidopsis thaliana	82-86
27792144-7	2016	In addition, the expression of some Fe acquisition-related genes, including FIT1, FRO2, and IRT1 were significantly up-regulated by melatonin treatments, whereas the enhanced expression of these genes was obviously suppressed in the polyamine- and NO-deficient plants.	Melatonin	132-141	ferric reduction oxidase 2	Arabidopsis thaliana	82-86
24711810-4	2014	Arabidopsis FRO2 was first identified as the ferric chelate reductase that reduces ferric iron-chelates at the root surface-rhizosphere interface.	ferric sulfate	83-94	ferric reduction oxidase 2	Arabidopsis thaliana	12-16
26333047-9	2015	The key genes involved in Fe uptake, including IRT1, FRO2 and FIT, are expressed at low levels in zir1; however, a split-root experiment suggested that the systemic signals that govern the expression of Fe uptake-related genes are still active in zir1.	Iron	26-28	ferric reduction oxidase 2	Arabidopsis thaliana	53-57
26333047-9	2015	The key genes involved in Fe uptake, including IRT1, FRO2 and FIT, are expressed at low levels in zir1; however, a split-root experiment suggested that the systemic signals that govern the expression of Fe uptake-related genes are still active in zir1.	Iron	203-205	ferric reduction oxidase 2	Arabidopsis thaliana	53-57
25289518-7	2014	There was a significant induction of FRO2 in KAuCl4-treated roots, and therefore its likely involvement in bioreduction of Au(3)(+) could be assumed.	gold tetrachloride, acid	45-51	ferric reduction oxidase 2	Arabidopsis thaliana	37-41
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Zinc	161-163	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Iron	197-199	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Copper	207-209	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Iron	197-199	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Copper	235-237	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Iron	197-199	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Zinc	270-272	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24765096-6	2014	High Fe supply, in combination with the constitutive expression of AtFRO2, resulted in significantly higher concentrations of different minerals in roots (K, P, Zn, Ca, Ni, Mg, and Mo), pod walls (Fe, K, P, Cu, and Ni), leaves (Fe, P, Cu, Ca, Ni, and Mg) and seeds (Fe, Zn, Cu, and Ni).	Copper	235-237	ferric reduction oxidase 2	Arabidopsis thaliana	67-73
24549117-9	2014	The main actors in iron uptake and signaling (IRT1, FRO2, AHA2, AHA7 and FIT1) were strongly down-regulated upon exposure to uranyl.	Iron	19-23	ferric reduction oxidase 2	Arabidopsis thaliana	52-56
24549117-9	2014	The main actors in iron uptake and signaling (IRT1, FRO2, AHA2, AHA7 and FIT1) were strongly down-regulated upon exposure to uranyl.	uranyl	125-131	ferric reduction oxidase 2	Arabidopsis thaliana	52-56
26415695-0	2016	Facilitated Fe Nutrition by Phenolic Compounds Excreted by the Arabidopsis ABCG37/PDR9 Transporter Requires the IRT1/FRO2 High-Affinity Root Fe(2+) Transport System.	Iron	12-14	ferric reduction oxidase 2	Arabidopsis thaliana	117-121
26415695-0	2016	Facilitated Fe Nutrition by Phenolic Compounds Excreted by the Arabidopsis ABCG37/PDR9 Transporter Requires the IRT1/FRO2 High-Affinity Root Fe(2+) Transport System.	ammonium ferrous sulfate	141-147	ferric reduction oxidase 2	Arabidopsis thaliana	117-121
26644507-3	2016	Exogenous application of Suc further stimulated Fe deficiency-induced ferric-chelate-reductase (FCR) activity and expression of Fe acquisition-related genes FRO2, IRT1, and FIT in roots.	Sucrose	25-28	ferric reduction oxidase 2	Arabidopsis thaliana	157-161
26307542-4	2015	In response to VOC treatment, MYB72 is co-expressed with the iron uptake-related genes FERRIC REDUCTION OXIDASE 2 (FRO2) and IRON-REGULATED TRANSPORTER 1 (IRT1) in a manner that is dependent on FER-LIKE IRON DEFICIENCY TRANSCRIPTION FACTOR (FIT), indicating that MYB72 is an intrinsic part of the plant"s iron-acquisition response that is typically activated upon iron starvation.	Iron	61-65	ferric reduction oxidase 2	Arabidopsis thaliana	87-113
24889527-8	2014	Furthermore, we showed that MED16 interacted with FIT and improved the binding of the FIT/Ib bHLH complex to FRO2 and IRT1 promoters under iron-deficient conditions.	Iron	139-143	ferric reduction oxidase 2	Arabidopsis thaliana	109-113
24192296-1	2014	In dicots, iron (Fe) is acquired from the soil by IRT1 (IRON-REGULATED TRANSPORTER 1) and FRO2 (FERRIC REDUCTION OXIDASE 2) that are localized at the root epidermis.	Iron	11-15	ferric reduction oxidase 2	Arabidopsis thaliana	90-94
24456400-8	2014	In particular, the transcription levels of FIT, IRT1 and FRO2 were reduced in the yid1 and med25 mutants under iron-deficient conditions.	Iron	111-115	ferric reduction oxidase 2	Arabidopsis thaliana	57-61
24192296-1	2014	In dicots, iron (Fe) is acquired from the soil by IRT1 (IRON-REGULATED TRANSPORTER 1) and FRO2 (FERRIC REDUCTION OXIDASE 2) that are localized at the root epidermis.	Iron	17-19	ferric reduction oxidase 2	Arabidopsis thaliana	90-94
24192296-2	2014	IRT1 and FRO2 expression is induced by local and systemic signals under Fe-deficient conditions in Arabidopsis thaliana.	Iron	72-74	ferric reduction oxidase 2	Arabidopsis thaliana	9-13
23759098-7	2013	Under iron deficiency, atnas4 displayed a lower expression of the iron uptake-related genes IRT1 and FRO2 as well as a reduced ferric reductase activity.	Iron	6-10	ferric reduction oxidase 2	Arabidopsis thaliana	101-105
23742320-4	2014	Results found in this work show that hypoxia, generated by eliminating the aeration of the nutrient solution, can limit the expression of several Fe acquisition genes in Fe-deficient Arabidopsis, cucumber and pea plants, like the genes for ferric reductases AtFRO2, PsFRO1 and CsFRO1; iron transporters AtIRT1, PsRIT1 and CsIRT1; H(+) -ATPase CsHA1; and transcription factors AtFIT, AtbHLH38, and AtbHLH39.	Iron	146-148	ferric reduction oxidase 2	Arabidopsis thaliana	258-264
23590825-9	2013	Attenuation in the expression of Fe-responsive FRO2 and IRT1 in Zn- roots and their induction in Zn++ roots provided empirical evidence toward the prevalence of a cross talk between Zn and Fe homeostasis.	Iron	33-35	ferric reduction oxidase 2	Arabidopsis thaliana	47-51
23620481-5	2013	Evidence has been provided that overexpression of AtHO1 could confer plant tolerance to iron deficiency by improving expression of AtFIT, AtFRO2 and AtIRT1, the activity of ferric-chelate reductase (FCR) and iron accumulation.	Iron	88-92	ferric reduction oxidase 2	Arabidopsis thaliana	138-144
23590825-9	2013	Attenuation in the expression of Fe-responsive FRO2 and IRT1 in Zn- roots and their induction in Zn++ roots provided empirical evidence toward the prevalence of a cross talk between Zn and Fe homeostasis.	Zinc	64-66	ferric reduction oxidase 2	Arabidopsis thaliana	47-51
23590825-9	2013	Attenuation in the expression of Fe-responsive FRO2 and IRT1 in Zn- roots and their induction in Zn++ roots provided empirical evidence toward the prevalence of a cross talk between Zn and Fe homeostasis.	Zinc	97-101	ferric reduction oxidase 2	Arabidopsis thaliana	47-51
23590825-9	2013	Attenuation in the expression of Fe-responsive FRO2 and IRT1 in Zn- roots and their induction in Zn++ roots provided empirical evidence toward the prevalence of a cross talk between Zn and Fe homeostasis.	Iron	189-191	ferric reduction oxidase 2	Arabidopsis thaliana	47-51
20699398-5	2010	On the other hand, the root FCR activity, NO level, and gene expression of FIT and FRO2 were higher in auxin-overproducing mutant yucca under Fe deficiency, which were sharply restrained by 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide treatment.	1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole	190-255	ferric reduction oxidase 2	Arabidopsis thaliana	83-87
21426424-3	2011	To maintain iron homeostasis, the expression of FRO2 and IRT1 is tightly controlled by iron deficiency at the transcriptional level.	Iron	12-16	ferric reduction oxidase 2	Arabidopsis thaliana	48-52
21426424-4	2011	The basic helix-loop-helix (bHLH) transcription factor FIT represents the most upstream actor known in the iron-deficiency signaling pathway, and directly regulates the expression of the root iron uptake machinery genes FRO2 and IRT1.	Iron	107-111	ferric reduction oxidase 2	Arabidopsis thaliana	220-224
21426424-10	2011	In addition, we showed that FIT post-translational regulation by iron is required for FRO2 and IRT1 gene expression.	Iron	65-69	ferric reduction oxidase 2	Arabidopsis thaliana	86-90
22984573-4	2012	Only the basic helix-loop-helix (bHLH) transcription factor FIT has been shown to control the expression of the root iron uptake machinery genes FRO2 and IRT1.	Iron	117-121	ferric reduction oxidase 2	Arabidopsis thaliana	145-149
20055961-5	2010	Expression of AtIRT1, AtFRO2, AtFIT1 and AtFER1 was up-regulated by CO exposure in iron-deficient seedlings.	Iron	83-87	ferric reduction oxidase 2	Arabidopsis thaliana	22-28
20627899-1	2010	In a previous work it was shown that ethylene participates in the up-regulation of several Fe acquisition genes of Arabidopsis, such as AtFIT, AtFRO2, and AtIRT1.	ethylene	37-45	ferric reduction oxidase 2	Arabidopsis thaliana	143-149
20627899-1	2010	In a previous work it was shown that ethylene participates in the up-regulation of several Fe acquisition genes of Arabidopsis, such as AtFIT, AtFRO2, and AtIRT1.	Iron	91-93	ferric reduction oxidase 2	Arabidopsis thaliana	143-149
20627899-7	2010	The results obtained show that both ethylene and NO are involved in the up-regulation of many important Fe-regulated genes of Arabidopsis, such as AtFIT, AtbHLH38, AtbHLH39, AtFRO2, AtIRT1, AtNAS1, AtNAS2, AtFRD3, AtMYB72, and others.	ethylene	36-44	ferric reduction oxidase 2	Arabidopsis thaliana	174-180
19252923-2	2009	Consequently, plants carefully regulate their iron uptake, dependent on the FRO2 ferric reductase and the IRT1 transporter, to control its homeostasis.	Iron	46-50	ferric reduction oxidase 2	Arabidopsis thaliana	76-80
18513375-0	2008	The FRO2 ferric reductase is required for glycine betaine"s effect on chilling tolerance in Arabidopsis roots.	Betaine	42-57	ferric reduction oxidase 2	Arabidopsis thaliana	4-8
19188276-5	2009	The expression of iron-regulated genes including the IRT1/FRO2 iron uptake system is highly induced at the transcript level under both iron-sufficient and iron-deficient conditions.	Iron	18-22	ferric reduction oxidase 2	Arabidopsis thaliana	58-62
19188276-5	2009	The expression of iron-regulated genes including the IRT1/FRO2 iron uptake system is highly induced at the transcript level under both iron-sufficient and iron-deficient conditions.	Iron	63-67	ferric reduction oxidase 2	Arabidopsis thaliana	58-62
19188276-5	2009	The expression of iron-regulated genes including the IRT1/FRO2 iron uptake system is highly induced at the transcript level under both iron-sufficient and iron-deficient conditions.	Iron	63-67	ferric reduction oxidase 2	Arabidopsis thaliana	58-62
19188276-5	2009	The expression of iron-regulated genes including the IRT1/FRO2 iron uptake system is highly induced at the transcript level under both iron-sufficient and iron-deficient conditions.	Iron	63-67	ferric reduction oxidase 2	Arabidopsis thaliana	58-62
18513375-8	2008	These experiments identify a new physiological function for FRO2, i.e. blocking ROS accumulation during chilling.	Reactive Oxygen Species	80-83	ferric reduction oxidase 2	Arabidopsis thaliana	60-64
18513375-1	2008	FRO2 (At1g01580) codes for an NADPH-dependent ferric reductase in plasma membranes of root epidermal cells with a demonstrated role in iron uptake by plants.	Iron	135-139	ferric reduction oxidase 2	Arabidopsis thaliana	0-4
18513375-9	2008	They also suggest that GB has a major effect on FRO2 activity posttranscriptionally in the cold.	Betaine	23-25	ferric reduction oxidase 2	Arabidopsis thaliana	48-52
18513375-3	2008	We hypothesized that FRO2 was involved in chilling stress tolerance because its expression was upregulated by treatment of plants with glycine betaine (GB), a chemical that prevents reactive oxygen species (ROS) signaling in chilling stress.	Betaine	135-150	ferric reduction oxidase 2	Arabidopsis thaliana	21-25
18513375-3	2008	We hypothesized that FRO2 was involved in chilling stress tolerance because its expression was upregulated by treatment of plants with glycine betaine (GB), a chemical that prevents reactive oxygen species (ROS) signaling in chilling stress.	Betaine	152-154	ferric reduction oxidase 2	Arabidopsis thaliana	21-25
18513375-3	2008	We hypothesized that FRO2 was involved in chilling stress tolerance because its expression was upregulated by treatment of plants with glycine betaine (GB), a chemical that prevents reactive oxygen species (ROS) signaling in chilling stress.	Reactive Oxygen Species	182-205	ferric reduction oxidase 2	Arabidopsis thaliana	21-25
18513375-3	2008	We hypothesized that FRO2 was involved in chilling stress tolerance because its expression was upregulated by treatment of plants with glycine betaine (GB), a chemical that prevents reactive oxygen species (ROS) signaling in chilling stress.	Reactive Oxygen Species	207-210	ferric reduction oxidase 2	Arabidopsis thaliana	21-25
18513375-4	2008	This idea was confirmed by showing that the FRO2 null mutant frd1-1 failed to respond to GB in chilling assays either in relation to root growth recovery or inhibition of ROS accumulation.	Reactive Oxygen Species	171-174	ferric reduction oxidase 2	Arabidopsis thaliana	44-48
18513375-6	2008	In addition, 35S-FRO2 transgenics with elevated mRNA levels did not have improved chilling tolerance.	Sulfur-35	13-16	ferric reduction oxidase 2	Arabidopsis thaliana	17-21
18513375-7	2008	However, ferric reductase activity in wild-type plants or 35S-FRO2 transgenics pretreated with GB was several-fold higher after chilling compared with non-pretreated controls.	Betaine	95-97	ferric reduction oxidase 2	Arabidopsis thaliana	62-66
18697928-8	2008	A "metascreen" of previously collected ionomic data from 880 Arabidopsis mutants and natural accessions for this Fe response signature successfully identified the known Fe mutants frd1 and frd3.	Iron	113-115	ferric reduction oxidase 2	Arabidopsis thaliana	180-184
18397377-3	2008	In Arabidopsis, expression of IRT1 and FRO2 is tightly controlled to maintain iron homeostasis, and involves local and long-distance signals, as well as transcriptional and post-transcriptional events.	Iron	78-82	ferric reduction oxidase 2	Arabidopsis thaliana	39-43
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	12-16	ferric reduction oxidase 2	Arabidopsis thaliana	176-180
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	87-91	ferric reduction oxidase 2	Arabidopsis thaliana	176-180
18397377-7	2008	The CKs and iron-deficiency signals act through distinct pathways to regulate the soil iron uptake genes, as (i) CK repression is independent of the iron status, (ii) IRT1 and FRO2 downregulation is unchanged in a fit loss-of-function mutant, indicating that FIT does not mediate CK repression, and (iii) the iron-regulated genes AtNRAMP3 and AtNRAMP4 are not downregulated by CKs.	Iron	87-91	ferric reduction oxidase 2	Arabidopsis thaliana	176-180
16845482-1	2006	Iron uptake in Arabidopsis thaliana is mediated by ferric chelate reductase FRO2, a transmembrane protein belonging to the flavocytochrome b family.	Iron	0-4	ferric reduction oxidase 2	Arabidopsis thaliana	76-80
16741749-8	2006	However, the data indicate that constitutive FRO2 expression under non-iron stress conditions may lead to a decrease in plant productivity as reflected by reduced biomass accumulation in the transgenic events under non-iron stress conditions.	Iron	71-75	ferric reduction oxidase 2	Arabidopsis thaliana	45-49
16741749-8	2006	However, the data indicate that constitutive FRO2 expression under non-iron stress conditions may lead to a decrease in plant productivity as reflected by reduced biomass accumulation in the transgenic events under non-iron stress conditions.	Iron	219-223	ferric reduction oxidase 2	Arabidopsis thaliana	45-49
18268542-8	2008	Overexpression of FIT with either AtbHLH38 or AtbHLH39 in plants converted the expression of the iron uptake genes FRO2 and IRT1 from induced to constitutive.	Iron	97-101	ferric reduction oxidase 2	Arabidopsis thaliana	115-119
16845482-6	2006	The large water soluble domain of FRO2, which contains NADPH, FAD and oxidoreductase sequence motifs, was located on the inside of the membrane.	Water	10-15	ferric reduction oxidase 2	Arabidopsis thaliana	34-38
16845482-6	2006	The large water soluble domain of FRO2, which contains NADPH, FAD and oxidoreductase sequence motifs, was located on the inside of the membrane.	NADP	55-60	ferric reduction oxidase 2	Arabidopsis thaliana	34-38
16813577-7	2006	Further, transgenic frd4 plants accumulate FRO2-dHA fusion protein under iron-deficient conditions, suggesting that the frd4 mutation acts post-translationally in reducing Fe(III) chelate reductase activity.	Iron	73-77	ferric reduction oxidase 2	Arabidopsis thaliana	43-47
16813577-8	2006	FRO2-dHA appears to localize to the plasma membrane of root epidermal cells in both Col-0 and frd4-1 transgenic plants when grown under iron-deficient conditions.	dehydroacetic acid	5-8	ferric reduction oxidase 2	Arabidopsis thaliana	0-4
16813577-8	2006	FRO2-dHA appears to localize to the plasma membrane of root epidermal cells in both Col-0 and frd4-1 transgenic plants when grown under iron-deficient conditions.	Iron	136-140	ferric reduction oxidase 2	Arabidopsis thaliana	0-4
17085755-3	2006	This paper is a study of the effects of ethylene inhibitors and precursors on the expression of the genes encoding the ferric reductases and iron transporters of Arabidopsis thaliana (FRO2 and IRT1) and Lycopersicon esculentum (=Solanum lycopersicum) (FRO1 and IRT1) plants.	ethylene	40-48	ferric reduction oxidase 2	Arabidopsis thaliana	184-188
16362328-1	2006	The Arabidopsis FRO2 gene encodes the iron deficiency-inducible ferric chelate reductase responsible for reduction of iron at the root surface; subsequent transport of iron across the plasma membrane is carried out by a ferrous iron transporter (IRT1).	Iron	38-42	ferric reduction oxidase 2	Arabidopsis thaliana	16-20
16362328-1	2006	The Arabidopsis FRO2 gene encodes the iron deficiency-inducible ferric chelate reductase responsible for reduction of iron at the root surface; subsequent transport of iron across the plasma membrane is carried out by a ferrous iron transporter (IRT1).	Iron	118-122	ferric reduction oxidase 2	Arabidopsis thaliana	16-20
16362328-1	2006	The Arabidopsis FRO2 gene encodes the iron deficiency-inducible ferric chelate reductase responsible for reduction of iron at the root surface; subsequent transport of iron across the plasma membrane is carried out by a ferrous iron transporter (IRT1).	Iron	118-122	ferric reduction oxidase 2	Arabidopsis thaliana	16-20
16362328-9	2006	While it is known that FRO2 is expressed at high levels in the outer layers of iron-deficient roots, histochemical staining of FRO3-GUS plants revealed that FRO3 is predominantly expressed in the vascular cylinder of roots.	Iron	79-83	ferric reduction oxidase 2	Arabidopsis thaliana	23-27
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	145-149	ferric reduction oxidase 2	Arabidopsis thaliana	61-67
16006655-4	2005	An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control when expressed in yeast cells, indicating that the six AtFROs encode iron chelate reductases functioning in iron homeostasis in Arabidopsis.	Iron	264-268	ferric reduction oxidase 2	Arabidopsis thaliana	61-67
16006655-5	2005	AtFRO2 displayed the highest iron reduction activity among the AtFROs investigated, further demonstrating that AtFRO2 is a major iron reductase gene in Arabidopsis.	Iron	29-33	ferric reduction oxidase 2	Arabidopsis thaliana	0-6
16006655-5	2005	AtFRO2 displayed the highest iron reduction activity among the AtFROs investigated, further demonstrating that AtFRO2 is a major iron reductase gene in Arabidopsis.	Iron	29-33	ferric reduction oxidase 2	Arabidopsis thaliana	111-117
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	159-163	ferric reduction oxidase 2	Arabidopsis thaliana	84-90
16006655-7	2005	Considering the tissue-specific expression profiles of AtFRO genes, we suggest that AtFRO2 and AtFRO3 are two Fe(III) chelate reductases mainly functioning in iron acquisition and metabolism in Arabidopsis roots, while AtFRO5, AtFRO6, AtFRO7 and AtFRO8 are required for iron homeostasis in different tissues of shoots.	Iron	270-274	ferric reduction oxidase 2	Arabidopsis thaliana	84-90