PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset
29308052-7 2018 The CRMP4 promotor methylation level in paraffin-embedded tissues of the 10 patients with PMLP were determined and then compared to limited prostate cancer (LPCa) and its negative lymph node tissue [LPCa-LN (-) (10 cases)] and also to metastatic prostate adenocarcinoma (mPCa) and its positive lymph node tissue [mPCa-LN (+) (10 cases)]. Paraffin 40-48 dihydropyrimidinase like 3 Homo sapiens 4-9
33655336-5 2021 Radiation treatment- or Ca2+ ionophore A23187-induced apoptosis was significantly inhibited in CRMP4-deficient cells, including radiation-resistant or CRMP4-shRNA cell lines. Calcimycin 39-45 dihydropyrimidinase like 3 Homo sapiens 99-104
33655336-5 2021 Radiation treatment- or Ca2+ ionophore A23187-induced apoptosis was significantly inhibited in CRMP4-deficient cells, including radiation-resistant or CRMP4-shRNA cell lines. Calcimycin 39-45 dihydropyrimidinase like 3 Homo sapiens 164-169
33655336-6 2021 Furthermore, treatment of CRMP4-deficient cells with low levels (<5 microM) of BAPTA-AM, a Ca2+ chelator, resulted in radiation resistance. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 88-96 dihydropyrimidinase like 3 Homo sapiens 30-35
33655336-7 2021 Conversely, Ca2+ deficiency induced by a high BAPTA-AM concentration (>10 microM) resulted in higher cell death in the CRMP4-depleted cells compared to CRMP4-expressing control cells. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 46-54 dihydropyrimidinase like 3 Homo sapiens 123-128
28382925-5 2018 In the deferred ADT group, the values of the hazard ratios for tumor progression and cancer-specific mortality (CSM) in patients with >=15% CRMP4 methylation were 6.81 (95% CI: 2.34-19.80) and 12.83 (95% CI: 2.16-26.10), respectively. adt 16-19 dihydropyrimidinase like 3 Homo sapiens 143-148
29601651-11 2018 NF-kappaB RelA/p65 recruited DNMT1 to bind to and methylate CRMP4 promoter in which Serine276 phosphorylation of p65 was essential. serine276 84-93 dihydropyrimidinase like 3 Homo sapiens 60-65
23568759-1 2013 The dihydropyrimidinase-like 3 (DPYSL3) or Collapsin Response Mediator Protein 4a (CRMP4a) expression is modified in neurodegeneration and is involved in several ALS-associated pathways including axonal transport, glutamate excitotoxicity, and oxidative stress. Glutamic Acid 214-223 dihydropyrimidinase like 3 Homo sapiens 4-30
28122909-4 2017 Methods: CRMP4 promoter methylation at two previously identified CpG sites was determined in 80 case-matched biopsy samples (the training set) using bisulfite pyrosequencing. hydrogen sulfite 149-158 dihydropyrimidinase like 3 Homo sapiens 9-14
24011394-8 2013 We found that DPYSL3 levels increased during RA-induced cell differentiation. Tretinoin 45-47 dihydropyrimidinase like 3 Homo sapiens 14-20
26934554-9 2016 VEGF activated CRMP4 expression in gastric cancer cells, and this effect was significantly inhibited by MAPK and PI3K inhibitors (PD98059 and LY294002). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 130-137 dihydropyrimidinase like 3 Homo sapiens 15-20
26934554-9 2016 VEGF activated CRMP4 expression in gastric cancer cells, and this effect was significantly inhibited by MAPK and PI3K inhibitors (PD98059 and LY294002). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 142-150 dihydropyrimidinase like 3 Homo sapiens 15-20
25888628-8 2015 This proof-of-concept study with dTALEs for locus-specific epigenomic manipulation validates the selected CpG methylation of CRMP4 gene as an independent biomarker for diagnosis and prognosis of prostate cancer metastasis and opens up a novel avenue for mechanistic research on cancer biology. dtales 33-39 dihydropyrimidinase like 3 Homo sapiens 125-130
25670950-5 2015 RESULTS: Treatment with venlafaxine decreased expression of prolyl 4-hydroxylase (P4HB), ubiquitin-conjugating enzyme E2K (HIP2) and plastin 3 (T-plastin), and up-regulated expression of growth factor beta-3 (TGF-beta3), dihydropyrimidinase-like 3 (DPYSL3), and pyruvate kinase (PKM) after differentiation for 1 and 7 days. Venlafaxine Hydrochloride 24-35 dihydropyrimidinase like 3 Homo sapiens 221-247
25670950-5 2015 RESULTS: Treatment with venlafaxine decreased expression of prolyl 4-hydroxylase (P4HB), ubiquitin-conjugating enzyme E2K (HIP2) and plastin 3 (T-plastin), and up-regulated expression of growth factor beta-3 (TGF-beta3), dihydropyrimidinase-like 3 (DPYSL3), and pyruvate kinase (PKM) after differentiation for 1 and 7 days. Venlafaxine Hydrochloride 24-35 dihydropyrimidinase like 3 Homo sapiens 249-255
23568759-1 2013 The dihydropyrimidinase-like 3 (DPYSL3) or Collapsin Response Mediator Protein 4a (CRMP4a) expression is modified in neurodegeneration and is involved in several ALS-associated pathways including axonal transport, glutamate excitotoxicity, and oxidative stress. Glutamic Acid 214-223 dihydropyrimidinase like 3 Homo sapiens 32-38
16987501-0 2006 Involvement of nitric oxide synthase and ROS-mediated activation of L-type voltage-gated Ca2+ channels in NMDA-induced DPYSL3 degradation. ros 41-44 dihydropyrimidinase like 3 Homo sapiens 119-125
16987501-0 2006 Involvement of nitric oxide synthase and ROS-mediated activation of L-type voltage-gated Ca2+ channels in NMDA-induced DPYSL3 degradation. N-Methylaspartate 106-110 dihydropyrimidinase like 3 Homo sapiens 119-125
16987501-12 2006 These results indicate that changes in Ca(2+) homeostasis resulting from ROS-dependent activation of L-VGCC are sufficient to induce probable calpain-mediated DPYSL3 truncation and demonstrate for the first time the role of ROS in the mechanism leading to glutamate-induced calpain activation and DPYSL3 protein degradation. ros 73-76 dihydropyrimidinase like 3 Homo sapiens 159-165
16987501-12 2006 These results indicate that changes in Ca(2+) homeostasis resulting from ROS-dependent activation of L-VGCC are sufficient to induce probable calpain-mediated DPYSL3 truncation and demonstrate for the first time the role of ROS in the mechanism leading to glutamate-induced calpain activation and DPYSL3 protein degradation. ros 73-76 dihydropyrimidinase like 3 Homo sapiens 297-303
16987501-12 2006 These results indicate that changes in Ca(2+) homeostasis resulting from ROS-dependent activation of L-VGCC are sufficient to induce probable calpain-mediated DPYSL3 truncation and demonstrate for the first time the role of ROS in the mechanism leading to glutamate-induced calpain activation and DPYSL3 protein degradation. Glutamic Acid 256-265 dihydropyrimidinase like 3 Homo sapiens 159-165
16987501-2 2006 Recently, we have shown that in primary cortical neurons (PCN) NMDA and oxidative stress (H(2)O(2)) caused a calpain-dependent cleavage of DPYSL3 (62 kDa) resulting in the appearance of a lower molecular weight form (60 kDa) of DPYSL3. N-Methylaspartate 63-67 dihydropyrimidinase like 3 Homo sapiens 139-145
16987501-2 2006 Recently, we have shown that in primary cortical neurons (PCN) NMDA and oxidative stress (H(2)O(2)) caused a calpain-dependent cleavage of DPYSL3 (62 kDa) resulting in the appearance of a lower molecular weight form (60 kDa) of DPYSL3. N-Methylaspartate 63-67 dihydropyrimidinase like 3 Homo sapiens 228-234
16987501-3 2006 Our preliminary results had shown that antioxidants significantly reduced NMDA-induced DPYSL3 degradation, indicating involvement of ROS in calpain activation. N-Methylaspartate 74-78 dihydropyrimidinase like 3 Homo sapiens 87-93
16987501-3 2006 Our preliminary results had shown that antioxidants significantly reduced NMDA-induced DPYSL3 degradation, indicating involvement of ROS in calpain activation. ros 133-136 dihydropyrimidinase like 3 Homo sapiens 87-93
16987501-4 2006 The aim of this study was to investigate the possible involvement of NOS in NMDA-induced DPYSL3 degradation. N-Methylaspartate 76-80 dihydropyrimidinase like 3 Homo sapiens 89-95
16987501-5 2006 We found that NOS inhibitor (L-NAME) significantly prevented NMDA-induced ROS formation, as well as intracellular Ca(2+) increase [Ca(2+)](i), DPYSL3 degradation and cell death. NG-Nitroarginine Methyl Ester 29-35 dihydropyrimidinase like 3 Homo sapiens 143-149
16987501-6 2006 Further, exposure of PCN to NO donor (SNP) resulted in significant [Ca(2+)](i) increase, ROS generation and probable calpain-mediated DPYSL3 truncation. PREGNENOLONE CARBONITRILE 21-24 dihydropyrimidinase like 3 Homo sapiens 134-140
16987501-7 2006 The NMDA- and oxidative stress (ROS)-induced DPYSL3 truncation was totally dependent on extracellular [Ca(2+)](i). N-Methylaspartate 4-8 dihydropyrimidinase like 3 Homo sapiens 45-51
16987501-7 2006 The NMDA- and oxidative stress (ROS)-induced DPYSL3 truncation was totally dependent on extracellular [Ca(2+)](i). ros 32-35 dihydropyrimidinase like 3 Homo sapiens 45-51
16987501-8 2006 While NMDA-induced DPYSL3 truncation was blocked by both NMDA receptor antagonist (MK801) [Kowara, R., Chen, Q., Milliken, M., Chakravarthy, B., 2005. N-Methylaspartate 6-10 dihydropyrimidinase like 3 Homo sapiens 19-25
16987501-8 2006 While NMDA-induced DPYSL3 truncation was blocked by both NMDA receptor antagonist (MK801) [Kowara, R., Chen, Q., Milliken, M., Chakravarthy, B., 2005. Dizocilpine Maleate 83-88 dihydropyrimidinase like 3 Homo sapiens 19-25
16987501-9 2006 Calpain-mediated degradation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H(2)O(2) toxicity. N-Methylaspartate 91-95 dihydropyrimidinase like 3 Homo sapiens 32-66
16987501-9 2006 Calpain-mediated degradation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H(2)O(2) toxicity. N-Methylaspartate 91-95 dihydropyrimidinase like 3 Homo sapiens 68-74
16987501-11 2006 95 (2), 466-474] and L-VGCC (nimodipine) inhibitors, H(2)O(2)-induced increase in [Ca(2+)](i), ROS generation and DPYSL3 truncation was blocked only by nimodipine. Hydrogen Peroxide 53-61 dihydropyrimidinase like 3 Homo sapiens 114-120
16135096-0 2005 Calpain-mediated truncation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H2O2 toxicity. N-Methylaspartate 90-94 dihydropyrimidinase like 3 Homo sapiens 67-73
16611631-5 2006 Stimulation of neuroblastoma cells with IGF1 or TPA decreases GSK3 activity concomitantly with CRMP2 and CRMP4 phosphorylation. Tetradecanoylphorbol Acetate 48-51 dihydropyrimidinase like 3 Homo sapiens 105-110
16135096-0 2005 Calpain-mediated truncation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H2O2 toxicity. Hydrogen Peroxide 99-103 dihydropyrimidinase like 3 Homo sapiens 67-73
16135096-2 2005 In primary cortical cultures, glutamate (NMDA) excitotoxicity and oxidative stress (H2O2) caused the cleavage of DPYSL3, resulting in the appearance of a doublet of 62 kDa and 60 kDa. Glutamic Acid 30-39 dihydropyrimidinase like 3 Homo sapiens 113-119
16135096-2 2005 In primary cortical cultures, glutamate (NMDA) excitotoxicity and oxidative stress (H2O2) caused the cleavage of DPYSL3, resulting in the appearance of a doublet of 62 kDa and 60 kDa. N-Methylaspartate 41-45 dihydropyrimidinase like 3 Homo sapiens 113-119
16135096-2 2005 In primary cortical cultures, glutamate (NMDA) excitotoxicity and oxidative stress (H2O2) caused the cleavage of DPYSL3, resulting in the appearance of a doublet of 62 kDa and 60 kDa. Hydrogen Peroxide 84-88 dihydropyrimidinase like 3 Homo sapiens 113-119
16135096-4 2005 Furthermore, in vitro digestion of DPYSL3 in cell lysate with purified calpain revealed a cleavage product identical to that observed in NMDA- and H2O2-treated cells, and its appearance was blocked by calpain inhibitors. N-Methylaspartate 137-141 dihydropyrimidinase like 3 Homo sapiens 35-41
16135096-4 2005 Furthermore, in vitro digestion of DPYSL3 in cell lysate with purified calpain revealed a cleavage product identical to that observed in NMDA- and H2O2-treated cells, and its appearance was blocked by calpain inhibitors. Hydrogen Peroxide 147-151 dihydropyrimidinase like 3 Homo sapiens 35-41
16135096-5 2005 Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. Valine 87-90 dihydropyrimidinase like 3 Homo sapiens 16-22
16135096-5 2005 Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. Valine 87-90 dihydropyrimidinase like 3 Homo sapiens 121-127
16135096-5 2005 Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. Arginine 91-94 dihydropyrimidinase like 3 Homo sapiens 16-22
16135096-5 2005 Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. Arginine 91-94 dihydropyrimidinase like 3 Homo sapiens 121-127
16135096-5 2005 Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. Serine 95-98 dihydropyrimidinase like 3 Homo sapiens 16-22
16135096-5 2005 Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. Serine 95-98 dihydropyrimidinase like 3 Homo sapiens 121-127
15325126-6 2004 Validated genes included dopa decarboxylase, dopamine beta-hydroxylase, and dihydropyrimidinase-related protein 3, which were decreased in NBFL cells exposed to valproate, and spinocerebellar ataxia 7, which was increased in bipolar disease. Valproic Acid 161-170 dihydropyrimidinase like 3 Homo sapiens 76-113
12391592-5 2002 BrdU analysis revealed that CRMP-4 is expressed for a longer period than PSA in BrdU-labeled neurons. Bromodeoxyuridine 0-4 dihydropyrimidinase like 3 Homo sapiens 28-34
9628743-2 1998 A specific protein-DNA complex, termed DRP-3, was identified in an electrophoretic mobility shift assay (EMSA) using a cisplatin-damaged DNA probe. Cisplatin 119-128 dihydropyrimidinase like 3 Homo sapiens 39-44
9115293-0 1997 Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells. Tretinoin 41-54 dihydropyrimidinase like 3 Homo sapiens 121-126
9115293-5 1997 hUlip is also similar to the bacterial enzyme D-hydantoinase and the recently described vertebrate gene products CRMP62, TOAD-64, CRMP1, CRMP2, and mUNC. d-hydantoinase 46-60 dihydropyrimidinase like 3 Homo sapiens 0-5
35114375-0 2022 Allopregnanolone suppresses glioblastoma survival through decreasing DPYSL3 and S100A11 expression. Pregnanolone 0-16 dihydropyrimidinase like 3 Homo sapiens 69-75