PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
30617052-8	2019	For the meta-analysis of the GSTP1 Ile105Val polymorphism, compared with controls, an increased risk of NP cases was detected under the models of Val versus Ile (OR = 1.36; PA =0.027), Ile/Val versus Ile/Ile (OR = 1.70; PA =0.011) and Ile/Val+Val/Val versus Ile/Ile (OR = 1.65; PA =0.010).	Valine	41-44	glutathione S-transferase pi 1	Homo sapiens	29-34
30617052-8	2019	For the meta-analysis of the GSTP1 Ile105Val polymorphism, compared with controls, an increased risk of NP cases was detected under the models of Val versus Ile (OR = 1.36; PA =0.027), Ile/Val versus Ile/Ile (OR = 1.70; PA =0.011) and Ile/Val+Val/Val versus Ile/Ile (OR = 1.65; PA =0.010).	Isoleucine	35-38	glutathione S-transferase pi 1	Homo sapiens	29-34
30617052-8	2019	For the meta-analysis of the GSTP1 Ile105Val polymorphism, compared with controls, an increased risk of NP cases was detected under the models of Val versus Ile (OR = 1.36; PA =0.027), Ile/Val versus Ile/Ile (OR = 1.70; PA =0.011) and Ile/Val+Val/Val versus Ile/Ile (OR = 1.65; PA =0.010).	Valine	146-149	glutathione S-transferase pi 1	Homo sapiens	29-34
30728886-11	2019	MLT increased p-ERK1/2 and, when combined to DHA, increased GSTP1 expression (p < 0.01).	Docosahexaenoic Acids	45-48	glutathione S-transferase pi 1	Homo sapiens	60-65
30477822-10	2019	The positive association between PM2.5 in and homocysteine was (borderline) statistically significantly modified by genetic variants in MnSOD (p interaction = 0.02), GSTP1 (p interaction = 0.07) and the sum score of the 3 studied SNPs in the CAT gene (p interaction=0.09), suggesting oxidative stress as an underlying mechanism of action.	Homocysteine	46-58	glutathione S-transferase pi 1	Homo sapiens	166-171
30290218-0	2019	Targeting glutathione S-transferase P and its interactome with selenium compounds in cancer therapy.	Selenium	63-71	glutathione S-transferase pi 1	Homo sapiens	10-37
30290218-2	2019	At the same time, these compounds can be used to modulate the expression and multiple activities of GSTs and other glutathione-dependent genes, that are important aspects in both the chemoprevention and therapy of drug-resistant cancers.	Glutathione	115-126	glutathione S-transferase pi 1	Homo sapiens	100-104
30290218-4	2019	Besides promoting GSH-dependent detoxification of cellular electrophiles, GSTP physically interacts with a number of small molecules and cellular proteins producing regulatory effects across the main signal transduction and transcription pathways (identified as the "regulatory interactome of GSTP").	Glutathione	18-21	glutathione S-transferase pi 1	Homo sapiens	74-78
30290218-4	2019	Besides promoting GSH-dependent detoxification of cellular electrophiles, GSTP physically interacts with a number of small molecules and cellular proteins producing regulatory effects across the main signal transduction and transcription pathways (identified as the "regulatory interactome of GSTP").	Glutathione	18-21	glutathione S-transferase pi 1	Homo sapiens	293-297
30290218-5	2019	An emerging molecular mechanism behind such regulatory function is the activity of GSTP as a redox chaperonine responsible for the selective glutathionylation of protein Cys residues in the different subcellular compartments.	chaperonine	99-110	glutathione S-transferase pi 1	Homo sapiens	83-87
30290218-5	2019	An emerging molecular mechanism behind such regulatory function is the activity of GSTP as a redox chaperonine responsible for the selective glutathionylation of protein Cys residues in the different subcellular compartments.	Cysteine	170-173	glutathione S-transferase pi 1	Homo sapiens	83-87
31084595-9	2019	Disulfiram has also been shown to inhibit the proteasomes, DNA topoisomerases, DNA methyltransferase, glutathione S-transferase P1, and O6- methylguanine DNA methyltransferase, a DNA repair protein highly expressed in brain tumors.	Disulfiram	0-10	glutathione S-transferase pi 1	Homo sapiens	102-130
30286549-10	2018	Urinary inorganic arsenic (%InAs) was associated with GSTP1, LADD, GSTP1*Age, GSTP1*alcohol consumption (r2 = 0.43; likelihood-ratio test, p = 0.000).	inorganic	8-17	glutathione S-transferase pi 1	Homo sapiens	54-59
30286549-12	2018	GSTP1 (AG + GG) homozygotes/heterozygotes could increase urinary %InAs and decrease the PMI ratio in people exposed to low and high As from drinking groundwater.	pmi	88-91	glutathione S-transferase pi 1	Homo sapiens	0-5
30619815-2	2018	Piperlongumine (PL) is an anticancer compound whose activity is related to the inhibition of human glutathione transferase of pi class (GSTP1) overexpressed in cancerous tumors and implicated in the metabolism of electrophilic compounds.	piperlonguminine	0-14	glutathione S-transferase pi 1	Homo sapiens	136-141
30286549-10	2018	Urinary inorganic arsenic (%InAs) was associated with GSTP1, LADD, GSTP1*Age, GSTP1*alcohol consumption (r2 = 0.43; likelihood-ratio test, p = 0.000).	inorganic	8-17	glutathione S-transferase pi 1	Homo sapiens	67-72
30286549-10	2018	Urinary inorganic arsenic (%InAs) was associated with GSTP1, LADD, GSTP1*Age, GSTP1*alcohol consumption (r2 = 0.43; likelihood-ratio test, p = 0.000).	inorganic	8-17	glutathione S-transferase pi 1	Homo sapiens	67-72
30286549-10	2018	Urinary inorganic arsenic (%InAs) was associated with GSTP1, LADD, GSTP1*Age, GSTP1*alcohol consumption (r2 = 0.43; likelihood-ratio test, p = 0.000).	Arsenic	18-25	glutathione S-transferase pi 1	Homo sapiens	54-59
30286549-10	2018	Urinary inorganic arsenic (%InAs) was associated with GSTP1, LADD, GSTP1*Age, GSTP1*alcohol consumption (r2 = 0.43; likelihood-ratio test, p = 0.000).	Arsenic	18-25	glutathione S-transferase pi 1	Homo sapiens	67-72
30286549-10	2018	Urinary inorganic arsenic (%InAs) was associated with GSTP1, LADD, GSTP1*Age, GSTP1*alcohol consumption (r2 = 0.43; likelihood-ratio test, p = 0.000).	Arsenic	18-25	glutathione S-transferase pi 1	Homo sapiens	67-72
30286549-10	2018	Urinary inorganic arsenic (%InAs) was associated with GSTP1, LADD, GSTP1*Age, GSTP1*alcohol consumption (r2 = 0.43; likelihood-ratio test, p = 0.000).	indium arsenide	28-32	glutathione S-transferase pi 1	Homo sapiens	54-59
30286549-10	2018	Urinary inorganic arsenic (%InAs) was associated with GSTP1, LADD, GSTP1*Age, GSTP1*alcohol consumption (r2 = 0.43; likelihood-ratio test, p = 0.000).	indium arsenide	28-32	glutathione S-transferase pi 1	Homo sapiens	67-72
30286549-10	2018	Urinary inorganic arsenic (%InAs) was associated with GSTP1, LADD, GSTP1*Age, GSTP1*alcohol consumption (r2 = 0.43; likelihood-ratio test, p = 0.000).	indium arsenide	28-32	glutathione S-transferase pi 1	Homo sapiens	67-72
30286549-12	2018	GSTP1 (AG + GG) homozygotes/heterozygotes could increase urinary %InAs and decrease the PMI ratio in people exposed to low and high As from drinking groundwater.	indium arsenide	66-70	glutathione S-transferase pi 1	Homo sapiens	0-5
30153066-2	2018	The multifunctional GST pi-isoform (GSTP) catalyzes the conjugation of glutathione with acrolein and inhibits c-Jun NH2-terminal kinase (JNK) activation.	Glutathione	71-82	glutathione S-transferase pi 1	Homo sapiens	36-40
30372807-4	2018	There are different genes like GSTP1 and ABCB1 which are responsible for oxaliplatin resistance.	Oxaliplatin	73-84	glutathione S-transferase pi 1	Homo sapiens	31-36
30153066-2	2018	The multifunctional GST pi-isoform (GSTP) catalyzes the conjugation of glutathione with acrolein and inhibits c-Jun NH2-terminal kinase (JNK) activation.	Acrolein	88-96	glutathione S-transferase pi 1	Homo sapiens	36-40
30153066-7	2018	Treatment of GSTP-null mice with the JNK inhibitor 1,9-pyrazoloanthrone (SP600125) significantly attenuated pyruvate-induced hepatic gluconeogenesis and significantly altered correlations between hepatic cytokine mRNAs and metabolic outcomes in GSTP-null mice.	pyrazolanthrone	51-71	glutathione S-transferase pi 1	Homo sapiens	13-17
30153066-7	2018	Treatment of GSTP-null mice with the JNK inhibitor 1,9-pyrazoloanthrone (SP600125) significantly attenuated pyruvate-induced hepatic gluconeogenesis and significantly altered correlations between hepatic cytokine mRNAs and metabolic outcomes in GSTP-null mice.	pyrazolanthrone	51-71	glutathione S-transferase pi 1	Homo sapiens	245-249
30153066-7	2018	Treatment of GSTP-null mice with the JNK inhibitor 1,9-pyrazoloanthrone (SP600125) significantly attenuated pyruvate-induced hepatic gluconeogenesis and significantly altered correlations between hepatic cytokine mRNAs and metabolic outcomes in GSTP-null mice.	pyrazolanthrone	73-81	glutathione S-transferase pi 1	Homo sapiens	13-17
30153066-7	2018	Treatment of GSTP-null mice with the JNK inhibitor 1,9-pyrazoloanthrone (SP600125) significantly attenuated pyruvate-induced hepatic gluconeogenesis and significantly altered correlations between hepatic cytokine mRNAs and metabolic outcomes in GSTP-null mice.	pyrazolanthrone	73-81	glutathione S-transferase pi 1	Homo sapiens	245-249
30153066-7	2018	Treatment of GSTP-null mice with the JNK inhibitor 1,9-pyrazoloanthrone (SP600125) significantly attenuated pyruvate-induced hepatic gluconeogenesis and significantly altered correlations between hepatic cytokine mRNAs and metabolic outcomes in GSTP-null mice.	Pyruvic Acid	108-116	glutathione S-transferase pi 1	Homo sapiens	13-17
30153066-7	2018	Treatment of GSTP-null mice with the JNK inhibitor 1,9-pyrazoloanthrone (SP600125) significantly attenuated pyruvate-induced hepatic gluconeogenesis and significantly altered correlations between hepatic cytokine mRNAs and metabolic outcomes in GSTP-null mice.	Pyruvic Acid	108-116	glutathione S-transferase pi 1	Homo sapiens	245-249
30153066-8	2018	Collectively, these findings suggest that hepatic GSTP plays a pivotal role in glucose handling by regulating JNK-dependent control of hepatic gluconeogenesis.	Glucose	79-86	glutathione S-transferase pi 1	Homo sapiens	50-54
30153066-9	2018	Thus, hepatic GSTP-JNK dysregulation may be a target of new therapeutic interventions during early stages of glucose intolerance to prevent the worsening metabolic derangements associated with human obesity and its relentless progression to diabetes.	Glucose	109-116	glutathione S-transferase pi 1	Homo sapiens	14-18
30238837-0	2018	Relationship between GSTP1 rs1695 gene polymorphism and myelosuppression induced by platinum-based drugs: a meta-analysis.	Platinum	84-92	glutathione S-transferase pi 1	Homo sapiens	21-26
30930959-1	2018	Background: We previously reported a significant interactive association between polymorphisms of GSTP1 and blood manganese concentrations (BMC) with autism spectrum disorder (ASD) in Jamaican children.	Manganese	114-123	glutathione S-transferase pi 1	Homo sapiens	98-103
30930959-1	2018	Background: We previously reported a significant interactive association between polymorphisms of GSTP1 and blood manganese concentrations (BMC) with autism spectrum disorder (ASD) in Jamaican children.	bmc	140-143	glutathione S-transferase pi 1	Homo sapiens	98-103
30930959-5	2018	Results: Similar to the findings we reported previously, we found that in co-dominant and dominant models for GSTP1, among children with the Ile/Ile genotype, those with BMC > 12mug/L had 4.6 and 4.27 times higher odds of ASD compared to those with BMC < 12mug/L (adjusted Matched Odds Ratio (MOR) = 4.6, 95% CI: 1.21 - 17.42 and adjusted MOR = 4.27, 95% CI: 1.15 - 15.85, respectively).	bmc	170-173	glutathione S-transferase pi 1	Homo sapiens	110-115
30341887-2	2018	This study aimed to undertake a literature review and meta-analysis of GST gene polymorphisms, including GSTT1, GSTM1, and GSTP1 IIe105Val, and the treatment response to cisplatin-based chemotherapy in patients with NSCLC.	Cisplatin	170-179	glutathione S-transferase pi 1	Homo sapiens	123-128
30341887-6	2018	RESULTS Twenty-three published studies were identified that showed that both the null GSTM1 and the GG genotype of GSTP1 IIe105Val were associated with improved treatment response to cisplatin-based chemotherapy (GSTT1 present/null: OR=1.328; 95% CI, 1.074-1.643) (GSTP1 GG + AG vs. AA: OR=0.596; 95% CI, 0.468-0.759).	Cisplatin	183-192	glutathione S-transferase pi 1	Homo sapiens	115-120
30341887-6	2018	RESULTS Twenty-three published studies were identified that showed that both the null GSTM1 and the GG genotype of GSTP1 IIe105Val were associated with improved treatment response to cisplatin-based chemotherapy (GSTT1 present/null: OR=1.328; 95% CI, 1.074-1.643) (GSTP1 GG + AG vs. AA: OR=0.596; 95% CI, 0.468-0.759).	Cisplatin	183-192	glutathione S-transferase pi 1	Homo sapiens	265-270
30341887-8	2018	CONCLUSIONS Meta-analysis showed that the GG genotype of GSTP1 IIe105Val and the null GSTM1 genotype were associated with an improved treatment response to cisplatin-based chemotherapy in patients with NSCLC, especially in East-Asian patients.	Cisplatin	156-165	glutathione S-transferase pi 1	Homo sapiens	57-62
30238837-1	2018	Although many previous studies have reported the relationship between GSTP1 rs1695 gene polymorphism and myelosuppression induced by platinum-based drugs, the conclusions are not consistent.	Platinum	133-141	glutathione S-transferase pi 1	Homo sapiens	70-75
30238837-2	2018	The aim of the study is to evaluate the association between granulocytopenia and thrombocytopenia induced by platinum-based drugs and GSTP1 rs1695 gene polymorphism by meta-analysis.	Platinum	109-117	glutathione S-transferase pi 1	Homo sapiens	134-139
30238837-5	2018	GSTP1 rs1695 gene polymorphism showed a significant correlation with granulocytopenia induced by platinum-based drugs (dominant genetic model: OR=1.60, 95% CI=1.19.	Platinum	97-105	glutathione S-transferase pi 1	Homo sapiens	0-5
30238837-11	2018	In conclusion, the GSTP1 rs1695 gene polymorphism is associated with granulocytopenia induced by platinum-based drugs.	Platinum	97-105	glutathione S-transferase pi 1	Homo sapiens	19-24
29959055-1	2018	Glutathione S-transferases (GSTs) are phase II detoxifying enzymes involved in the maintenance of cell integrity, oxidative stress and protection against DNA damage by catalyzing the conjugation of glutathione to a wide variety of electrophilic substrates.	Glutathione	198-209	glutathione S-transferase pi 1	Homo sapiens	28-32
30313031-3	2018	This study investigates the relationship between the expression levels of lung resistance protein (LRP) and placental glutathione S-transferase-P1 (GSTP1), the resistance of primary epithelial ovarian cancer (PEOC) to chemotherapy, and the prognosis of patients with platinum drug-resistant PEOC.Quantitative PCR (QT-PCR) was used to detect the mRNA level of the resistance genes LRP, GSTP1 in all tissue and cell lines.The expression levels of resistance gene (LRP, GSTP1) in PEOC were the highest, followed by borderline adenoma tissues, and the lowest levels found in benign tumor tissues, the difference of genes expression between different tissues was statistically significant; the difference between the expression rates and relative expression level of drug resistance genes was statistically significant in platinum sensitive group compare with the platinum resistant group.	Platinum	817-825	glutathione S-transferase pi 1	Homo sapiens	118-146
30313031-3	2018	This study investigates the relationship between the expression levels of lung resistance protein (LRP) and placental glutathione S-transferase-P1 (GSTP1), the resistance of primary epithelial ovarian cancer (PEOC) to chemotherapy, and the prognosis of patients with platinum drug-resistant PEOC.Quantitative PCR (QT-PCR) was used to detect the mRNA level of the resistance genes LRP, GSTP1 in all tissue and cell lines.The expression levels of resistance gene (LRP, GSTP1) in PEOC were the highest, followed by borderline adenoma tissues, and the lowest levels found in benign tumor tissues, the difference of genes expression between different tissues was statistically significant; the difference between the expression rates and relative expression level of drug resistance genes was statistically significant in platinum sensitive group compare with the platinum resistant group.	Platinum	817-825	glutathione S-transferase pi 1	Homo sapiens	148-153
30313031-3	2018	This study investigates the relationship between the expression levels of lung resistance protein (LRP) and placental glutathione S-transferase-P1 (GSTP1), the resistance of primary epithelial ovarian cancer (PEOC) to chemotherapy, and the prognosis of patients with platinum drug-resistant PEOC.Quantitative PCR (QT-PCR) was used to detect the mRNA level of the resistance genes LRP, GSTP1 in all tissue and cell lines.The expression levels of resistance gene (LRP, GSTP1) in PEOC were the highest, followed by borderline adenoma tissues, and the lowest levels found in benign tumor tissues, the difference of genes expression between different tissues was statistically significant; the difference between the expression rates and relative expression level of drug resistance genes was statistically significant in platinum sensitive group compare with the platinum resistant group.	Platinum	267-275	glutathione S-transferase pi 1	Homo sapiens	118-146
30313031-3	2018	This study investigates the relationship between the expression levels of lung resistance protein (LRP) and placental glutathione S-transferase-P1 (GSTP1), the resistance of primary epithelial ovarian cancer (PEOC) to chemotherapy, and the prognosis of patients with platinum drug-resistant PEOC.Quantitative PCR (QT-PCR) was used to detect the mRNA level of the resistance genes LRP, GSTP1 in all tissue and cell lines.The expression levels of resistance gene (LRP, GSTP1) in PEOC were the highest, followed by borderline adenoma tissues, and the lowest levels found in benign tumor tissues, the difference of genes expression between different tissues was statistically significant; the difference between the expression rates and relative expression level of drug resistance genes was statistically significant in platinum sensitive group compare with the platinum resistant group.	Platinum	817-825	glutathione S-transferase pi 1	Homo sapiens	118-146
30313031-3	2018	This study investigates the relationship between the expression levels of lung resistance protein (LRP) and placental glutathione S-transferase-P1 (GSTP1), the resistance of primary epithelial ovarian cancer (PEOC) to chemotherapy, and the prognosis of patients with platinum drug-resistant PEOC.Quantitative PCR (QT-PCR) was used to detect the mRNA level of the resistance genes LRP, GSTP1 in all tissue and cell lines.The expression levels of resistance gene (LRP, GSTP1) in PEOC were the highest, followed by borderline adenoma tissues, and the lowest levels found in benign tumor tissues, the difference of genes expression between different tissues was statistically significant; the difference between the expression rates and relative expression level of drug resistance genes was statistically significant in platinum sensitive group compare with the platinum resistant group.	Platinum	267-275	glutathione S-transferase pi 1	Homo sapiens	148-153
30313031-3	2018	This study investigates the relationship between the expression levels of lung resistance protein (LRP) and placental glutathione S-transferase-P1 (GSTP1), the resistance of primary epithelial ovarian cancer (PEOC) to chemotherapy, and the prognosis of patients with platinum drug-resistant PEOC.Quantitative PCR (QT-PCR) was used to detect the mRNA level of the resistance genes LRP, GSTP1 in all tissue and cell lines.The expression levels of resistance gene (LRP, GSTP1) in PEOC were the highest, followed by borderline adenoma tissues, and the lowest levels found in benign tumor tissues, the difference of genes expression between different tissues was statistically significant; the difference between the expression rates and relative expression level of drug resistance genes was statistically significant in platinum sensitive group compare with the platinum resistant group.	Platinum	817-825	glutathione S-transferase pi 1	Homo sapiens	148-153
30038720-0	2018	GSTP1 rs1695 is associated with both hematological toxicity and prognosis of ovarian cancer treated with paclitaxel plus carboplatin combination chemotherapy: a comprehensive analysis using targeted resequencing of 100 pharmacogenes.	Paclitaxel	105-115	glutathione S-transferase pi 1	Homo sapiens	0-5
30172102-8	2018	Finally, we mimicked the intraocular environment of highly myopic eyes by treating LECs with hydrogen peroxide (H2O2) and observed both alterations in the methylation status of the GSTP1 and TXNRD2 promoters and time-dependent altered expression levels.	Hydrogen Peroxide	93-110	glutathione S-transferase pi 1	Homo sapiens	181-186
30172102-8	2018	Finally, we mimicked the intraocular environment of highly myopic eyes by treating LECs with hydrogen peroxide (H2O2) and observed both alterations in the methylation status of the GSTP1 and TXNRD2 promoters and time-dependent altered expression levels.	Hydrogen Peroxide	112-116	glutathione S-transferase pi 1	Homo sapiens	181-186
29727648-0	2018	Ligand-induced glutathione transferase degradation as a therapeutic modality: Investigation of a new metal-mediated affinity cleavage strategy for human GSTP1-1.	Metals	101-106	glutathione S-transferase pi 1	Homo sapiens	153-160
29727648-5	2018	The inhibitor [BDA-Fe(III)] was designed to possess two functional groups: the anthraquinone moiety, as recognition element by hGSTP1-1 and a metal chelated complex [iminodiacetic acid-Fe(III)] as a reactive moiety, able to generate reactive oxygen species (ROS), through Fenton reaction.	bda-fe(iii)	15-26	glutathione S-transferase pi 1	Homo sapiens	127-135
29727648-6	2018	Upon binding of the BDA-Fe(III) to hGSTP1-1 in the presence of hydrogen peroxide, reactive oxygen species (ROS) are generated, which promoted the specific cleavage of hGSTP1-1 in a time and concentration-dependent manner.	bda-fe(iii)	20-31	glutathione S-transferase pi 1	Homo sapiens	35-43
29727648-6	2018	Upon binding of the BDA-Fe(III) to hGSTP1-1 in the presence of hydrogen peroxide, reactive oxygen species (ROS) are generated, which promoted the specific cleavage of hGSTP1-1 in a time and concentration-dependent manner.	bda-fe(iii)	20-31	glutathione S-transferase pi 1	Homo sapiens	167-175
29727648-6	2018	Upon binding of the BDA-Fe(III) to hGSTP1-1 in the presence of hydrogen peroxide, reactive oxygen species (ROS) are generated, which promoted the specific cleavage of hGSTP1-1 in a time and concentration-dependent manner.	Hydrogen Peroxide	63-80	glutathione S-transferase pi 1	Homo sapiens	35-43
29727648-6	2018	Upon binding of the BDA-Fe(III) to hGSTP1-1 in the presence of hydrogen peroxide, reactive oxygen species (ROS) are generated, which promoted the specific cleavage of hGSTP1-1 in a time and concentration-dependent manner.	Hydrogen Peroxide	63-80	glutathione S-transferase pi 1	Homo sapiens	167-175
29727648-6	2018	Upon binding of the BDA-Fe(III) to hGSTP1-1 in the presence of hydrogen peroxide, reactive oxygen species (ROS) are generated, which promoted the specific cleavage of hGSTP1-1 in a time and concentration-dependent manner.	Reactive Oxygen Species	82-105	glutathione S-transferase pi 1	Homo sapiens	35-43
29727648-6	2018	Upon binding of the BDA-Fe(III) to hGSTP1-1 in the presence of hydrogen peroxide, reactive oxygen species (ROS) are generated, which promoted the specific cleavage of hGSTP1-1 in a time and concentration-dependent manner.	Reactive Oxygen Species	82-105	glutathione S-transferase pi 1	Homo sapiens	167-175
29727648-6	2018	Upon binding of the BDA-Fe(III) to hGSTP1-1 in the presence of hydrogen peroxide, reactive oxygen species (ROS) are generated, which promoted the specific cleavage of hGSTP1-1 in a time and concentration-dependent manner.	Reactive Oxygen Species	107-110	glutathione S-transferase pi 1	Homo sapiens	35-43
29727648-6	2018	Upon binding of the BDA-Fe(III) to hGSTP1-1 in the presence of hydrogen peroxide, reactive oxygen species (ROS) are generated, which promoted the specific cleavage of hGSTP1-1 in a time and concentration-dependent manner.	Reactive Oxygen Species	107-110	glutathione S-transferase pi 1	Homo sapiens	167-175
30038720-8	2018	Conclusion: Our study indicates that the GSTP1 rs1695 105Ile/105Ile genotype is associated with both severe hematotoxicity and high efficacy of TC therapy, identifying a possible prognostic indicator for patients with TC therapy.	Technetium	144-146	glutathione S-transferase pi 1	Homo sapiens	41-46
30038720-8	2018	Conclusion: Our study indicates that the GSTP1 rs1695 105Ile/105Ile genotype is associated with both severe hematotoxicity and high efficacy of TC therapy, identifying a possible prognostic indicator for patients with TC therapy.	Technetium	218-220	glutathione S-transferase pi 1	Homo sapiens	41-46
30038720-0	2018	GSTP1 rs1695 is associated with both hematological toxicity and prognosis of ovarian cancer treated with paclitaxel plus carboplatin combination chemotherapy: a comprehensive analysis using targeted resequencing of 100 pharmacogenes.	Carboplatin	121-132	glutathione S-transferase pi 1	Homo sapiens	0-5
29667773-0	2018	Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression through glutathione S-transferase P induction in T lymphocytic leukemia cells.	benzyl isothiocyanate	0-21	glutathione S-transferase pi 1	Homo sapiens	97-124
29807309-2	2018	Glutathione S-transferases (GSTs; EC 2.5.1.18) catalyze the conjugation of reduced glutathione (GSH) to a variety of xenobiotics and are normally recognized as detoxification enzymes.	Glutathione	83-94	glutathione S-transferase pi 1	Homo sapiens	28-32
29807309-2	2018	Glutathione S-transferases (GSTs; EC 2.5.1.18) catalyze the conjugation of reduced glutathione (GSH) to a variety of xenobiotics and are normally recognized as detoxification enzymes.	Glutathione	96-99	glutathione S-transferase pi 1	Homo sapiens	28-32
29807309-3	2018	Here, we used a colorimetric assay based on the human placental GSTP1-1 (hpGSTP1-1)-catalyzed reaction between GSH and the model substrate 1-chloro-2,4-dinitrobenzene (CDNB) as well as molecular docking to investigate the mechanistic and structural aspects of hpGSTP1-1 inhibition by DEL.	Glutathione	111-114	glutathione S-transferase pi 1	Homo sapiens	64-71
29807309-3	2018	Here, we used a colorimetric assay based on the human placental GSTP1-1 (hpGSTP1-1)-catalyzed reaction between GSH and the model substrate 1-chloro-2,4-dinitrobenzene (CDNB) as well as molecular docking to investigate the mechanistic and structural aspects of hpGSTP1-1 inhibition by DEL.	Dinitrochlorobenzene	139-166	glutathione S-transferase pi 1	Homo sapiens	64-71
29807309-3	2018	Here, we used a colorimetric assay based on the human placental GSTP1-1 (hpGSTP1-1)-catalyzed reaction between GSH and the model substrate 1-chloro-2,4-dinitrobenzene (CDNB) as well as molecular docking to investigate the mechanistic and structural aspects of hpGSTP1-1 inhibition by DEL.	Dinitrochlorobenzene	168-172	glutathione S-transferase pi 1	Homo sapiens	64-71
29204680-0	2018	Association between polymorphism of GSTP1, GSTT1, GSTM1 and CYP2E1 genes and susceptibility to benzene-induced hematotoxicity.	Benzene	95-102	glutathione S-transferase pi 1	Homo sapiens	36-41
29204680-3	2018	The main objective of this study was to ascertain whether polymorphism of GSTP1, GSTM1, GSTT1 and CYP2E1 genes might influence susceptibility to the adverse effects of benzene among employees of a petrochemical plant.	Benzene	168-175	glutathione S-transferase pi 1	Homo sapiens	74-79
29627155-9	2018	Proteomic studies on the 20 micromol/L FTI-277 and 5 micromol/L alendronate +20 micromol/L FTI-277 treated cells revealed altered expression of different proteins including peroxiredoxin 2 (Prx2), glutathione S transferase 1 (GSTP1), Rho GTPase activating protein (RhoGAP), triosephosphate isomerase (TPI), and heat shock protein 60 (HSP60).	Alendronate	64-75	glutathione S-transferase pi 1	Homo sapiens	226-231
29667773-0	2018	Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression through glutathione S-transferase P induction in T lymphocytic leukemia cells.	Hydrogen Peroxide	37-54	glutathione S-transferase pi 1	Homo sapiens	97-124
29667773-5	2018	A GSTP1/2-specific inhibitor, 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX), significantly counteracted the inhibitory effect of BITC on the hydrogen peroxide-enhanced IL-13 upregulation as well as the c-Jun nuclear translocation.	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	30-77	glutathione S-transferase pi 1	Homo sapiens	2-9
29667773-5	2018	A GSTP1/2-specific inhibitor, 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX), significantly counteracted the inhibitory effect of BITC on the hydrogen peroxide-enhanced IL-13 upregulation as well as the c-Jun nuclear translocation.	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	79-85	glutathione S-transferase pi 1	Homo sapiens	2-9
29667773-5	2018	A GSTP1/2-specific inhibitor, 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX), significantly counteracted the inhibitory effect of BITC on the hydrogen peroxide-enhanced IL-13 upregulation as well as the c-Jun nuclear translocation.	Hydrogen Peroxide	152-169	glutathione S-transferase pi 1	Homo sapiens	2-9
29348462-7	2018	Instead, we demonstrated that glutathione S-transferase pi 1 (GSTP1), a GST family member that catalyzes the conjugation of GSH with electrophilic compounds to fulfill its detoxification function, is highly expressed in HNSCC tissues.	Glutathione	124-127	glutathione S-transferase pi 1	Homo sapiens	62-67
29348462-0	2018	Piperlongumine and p53-reactivator APR-246 selectively induce cell death in HNSCC by targeting GSTP1.	piperlonguminine	0-14	glutathione S-transferase pi 1	Homo sapiens	95-100
29348462-8	2018	Administration of PL and APR-246 significantly suppresses GSTP1 activity, resulting in the accumulation of ROS, depletion of GSH, elevation of GSSG, and DNA damage.	ros	107-110	glutathione S-transferase pi 1	Homo sapiens	58-63
29348462-8	2018	Administration of PL and APR-246 significantly suppresses GSTP1 activity, resulting in the accumulation of ROS, depletion of GSH, elevation of GSSG, and DNA damage.	Glutathione	125-128	glutathione S-transferase pi 1	Homo sapiens	58-63
29348462-9	2018	Ectopic expression of GSTP1 or pre-treatment with antioxidant N-acetyl-L-cysteine (NAC) abrogates the ROS elevation and decreases DNA damage, apoptosis, and autophagic cell death prompted by PL/APR-246.	ros	102-105	glutathione S-transferase pi 1	Homo sapiens	22-27
29348462-7	2018	Instead, we demonstrated that glutathione S-transferase pi 1 (GSTP1), a GST family member that catalyzes the conjugation of GSH with electrophilic compounds to fulfill its detoxification function, is highly expressed in HNSCC tissues.	Glutathione	124-127	glutathione S-transferase pi 1	Homo sapiens	30-60
28503938-0	2018	Design and synthesis of 2-substituted-5-(4-trifluoromethylphenyl-sulphonamido)benzoxazole derivatives as human GST P1-1 inhibitors.	2-substituted-5-(4-trifluoromethylphenyl-sulphonamido)benzoxazole	24-89	glutathione S-transferase pi 1	Homo sapiens	111-119
28503938-5	2018	In this study, new hGST P1-1 inhibitors, 2-(4-substitutedphenyl/benzyl)-5-(4-trifluoromethylphenylsulphonamido) benzoxazole derivatives (Va-Vk) have been designed and synthesized.	Vanillic Acid	137-139	glutathione S-transferase pi 1	Homo sapiens	19-28
28503938-7	2018	Additionally we compared the interactions with hGST P1-1 enzyme of newly synthesized compound Vh (bearing CF3 group) and previously synthesized compound 5f (bearing NO2 group).	Nitrogen Dioxide	165-168	glutathione S-transferase pi 1	Homo sapiens	47-56
29411558-0	2018	Interactions Between Bisphenol A Exposure and GSTP1 Polymorphisms in Childhood Asthma.	bisphenol A	21-32	glutathione S-transferase pi 1	Homo sapiens	46-51
29505746-5	2018	Our findings rate the effect of single-nucleotide polymorphisms of GSTP1 and/or NAT2 in modulation of the risk of male infertility in subjects from Vietnam.	single-nucleotide	32-49	glutathione S-transferase pi 1	Homo sapiens	67-72
29720942-0	2018	Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells.	Amodiaquine	46-57	glutathione S-transferase pi 1	Homo sapiens	0-28
29720942-0	2018	Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells.	quinoneimines	58-71	glutathione S-transferase pi 1	Homo sapiens	0-28
29720942-2	2018	Glutathione conjugation protects against AQ-induced toxicity and GSTP1 is able to conjugate its quinoneimine metabolites AQ-QI and DEA-QI with glutathione.	Amodiaquine	41-43	glutathione S-transferase pi 1	Homo sapiens	65-70
29720942-2	2018	Glutathione conjugation protects against AQ-induced toxicity and GSTP1 is able to conjugate its quinoneimine metabolites AQ-QI and DEA-QI with glutathione.	quinoneimine	96-108	glutathione S-transferase pi 1	Homo sapiens	65-70
29720942-2	2018	Glutathione conjugation protects against AQ-induced toxicity and GSTP1 is able to conjugate its quinoneimine metabolites AQ-QI and DEA-QI with glutathione.	Amodiaquine	121-123	glutathione S-transferase pi 1	Homo sapiens	65-70
29720942-2	2018	Glutathione conjugation protects against AQ-induced toxicity and GSTP1 is able to conjugate its quinoneimine metabolites AQ-QI and DEA-QI with glutathione.	Glutathione	143-154	glutathione S-transferase pi 1	Homo sapiens	65-70
29720942-8	2018	Overexpression of GSTP1 resulted in a two-fold increase in GSH-conjugation of the QIs, attenuated QI-induced cytotoxicity especially under GSH-depletion condition, abolished QIs-induced apoptosis but did not significantly inhibit the activation of the ER stress response.	Glutathione	59-62	glutathione S-transferase pi 1	Homo sapiens	18-23
29720942-8	2018	Overexpression of GSTP1 resulted in a two-fold increase in GSH-conjugation of the QIs, attenuated QI-induced cytotoxicity especially under GSH-depletion condition, abolished QIs-induced apoptosis but did not significantly inhibit the activation of the ER stress response.	Glutathione	139-142	glutathione S-transferase pi 1	Homo sapiens	18-23
29720942-9	2018	In conclusion, these results indicate a protective role of GSTP1 by increasing enzymatic detoxification of AQ-QI and DEAQ-QI and suggest a second protective mechanism by interfering with ER stress induced apoptosis.	amodiaquine quinoneimine	107-112	glutathione S-transferase pi 1	Homo sapiens	59-64
29720942-9	2018	In conclusion, these results indicate a protective role of GSTP1 by increasing enzymatic detoxification of AQ-QI and DEAQ-QI and suggest a second protective mechanism by interfering with ER stress induced apoptosis.	deaq-qi	117-124	glutathione S-transferase pi 1	Homo sapiens	59-64
29328427-0	2018	miR-133b reverses cisplatin resistance by targeting GSTP1 in cisplatin-resistant lung cancer cells.	Cisplatin	18-27	glutathione S-transferase pi 1	Homo sapiens	52-57
29328427-0	2018	miR-133b reverses cisplatin resistance by targeting GSTP1 in cisplatin-resistant lung cancer cells.	Cisplatin	61-70	glutathione S-transferase pi 1	Homo sapiens	52-57
29328427-3	2018	Reverse transcription-quantitative polymerase chain reaction and western blot assays of the cisplatin-resistant cell lines A549/DPP and H1299/DDP displayed the reduced expression of miR-133b and increased expression of glutathione-S-transferase P1 (GSTP1) in the resistant cells compared with the respective parental cell lines A549 and H1299.	Cisplatin	92-101	glutathione S-transferase pi 1	Homo sapiens	219-247
29328427-3	2018	Reverse transcription-quantitative polymerase chain reaction and western blot assays of the cisplatin-resistant cell lines A549/DPP and H1299/DDP displayed the reduced expression of miR-133b and increased expression of glutathione-S-transferase P1 (GSTP1) in the resistant cells compared with the respective parental cell lines A549 and H1299.	Cisplatin	92-101	glutathione S-transferase pi 1	Homo sapiens	249-254
29328427-7	2018	In conclusion, the present study findings provide the insights that miR-133b reduces cisplatin resistance and its overexpression contributes to the suppression of the malignant growth and aggressiveness of cisplatin-resistant NSCLC cells by targeting GSTP1.	Cisplatin	206-215	glutathione S-transferase pi 1	Homo sapiens	251-256
29411558-9	2018	Compared to the GG genotype, children with a GSTP1 AA genotype had higher urine BPAG concentrations (geometric mean [standard error], 12.72 [4.16] vs 11.42 [2.82]; P=0.036).	bisphenol A glucuronide	80-84	glutathione S-transferase pi 1	Homo sapiens	45-50
29411558-10	2018	In children with high BPAG, the GSTP1 AA genotype was related to a higher odds of asthma than the GG genotype (aOR, 4.84; 95% CI, 1.0223.06).	bisphenol A glucuronide	22-26	glutathione S-transferase pi 1	Homo sapiens	32-37
29411558-11	2018	CONCLUSIONS: GSTP1 variants are associated with urine BPA metabolite levels.	bisphenol A	54-57	glutathione S-transferase pi 1	Homo sapiens	13-18
29310316-0	2018	Fluorescein diacetate (FDA) and its analogue as substrates for Pi-class glutathione S-transferase (GSTP1) and their biological application.	diacetylfluorescein	0-21	glutathione S-transferase pi 1	Homo sapiens	99-104
29063946-12	2018	The GSTP1 variant increased susceptibility of individuals to harmful effects of NO x .	Nitric Oxide	80-84	glutathione S-transferase pi 1	Homo sapiens	4-9
29358310-3	2018	In particular, 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol (NBDHEX) is extensively studied, which is a very efficient inhibitor of GSTP1-1.	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	15-63	glutathione S-transferase pi 1	Homo sapiens	136-143
29358310-3	2018	In particular, 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol (NBDHEX) is extensively studied, which is a very efficient inhibitor of GSTP1-1.	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	65-71	glutathione S-transferase pi 1	Homo sapiens	136-143
29063946-7	2018	GSTP1 was significantly associated with the south region, where the variant (AG+GG) genotype was associated with increased 8-OHdG levels as a result of NO x exposure (p < 0.05).	8-ohdg	123-129	glutathione S-transferase pi 1	Homo sapiens	0-5
29310316-0	2018	Fluorescein diacetate (FDA) and its analogue as substrates for Pi-class glutathione S-transferase (GSTP1) and their biological application.	diacetylfluorescein	23-26	glutathione S-transferase pi 1	Homo sapiens	99-104
29310316-3	2018	Here we demonstrate that fluorescein diacetate (FDA), a fluorescent probe used for vital staining, is a fluorescently activated by esterolytic activity of human GSTP1 (hGSTP1) selectively among various cytosolic GSTs.	diacetylfluorescein	25-46	glutathione S-transferase pi 1	Homo sapiens	161-166
29310316-3	2018	Here we demonstrate that fluorescein diacetate (FDA), a fluorescent probe used for vital staining, is a fluorescently activated by esterolytic activity of human GSTP1 (hGSTP1) selectively among various cytosolic GSTs.	diacetylfluorescein	25-46	glutathione S-transferase pi 1	Homo sapiens	168-174
29310316-3	2018	Here we demonstrate that fluorescein diacetate (FDA), a fluorescent probe used for vital staining, is a fluorescently activated by esterolytic activity of human GSTP1 (hGSTP1) selectively among various cytosolic GSTs.	diacetylfluorescein	48-51	glutathione S-transferase pi 1	Homo sapiens	161-166
29310316-3	2018	Here we demonstrate that fluorescein diacetate (FDA), a fluorescent probe used for vital staining, is a fluorescently activated by esterolytic activity of human GSTP1 (hGSTP1) selectively among various cytosolic GSTs.	diacetylfluorescein	48-51	glutathione S-transferase pi 1	Homo sapiens	168-174
29310316-4	2018	Fluorescence activation of FDA susceptible to GST inhibitors was observed in MCF7 cells exogenously overexpressing hGSTP1, but not in cells overexpressing hGSTA1 or hGSTM1.	diacetylfluorescein	27-30	glutathione S-transferase pi 1	Homo sapiens	115-121
29310316-5	2018	Inhibitor-sensitive fluorescence activation was also observed in several cancer cell lines endogenously expressing GSTP1, suggesting that GSTP1 is involved in FDA esterolysis in these cells.	diacetylfluorescein	159-162	glutathione S-transferase pi 1	Homo sapiens	115-120
29310316-5	2018	Inhibitor-sensitive fluorescence activation was also observed in several cancer cell lines endogenously expressing GSTP1, suggesting that GSTP1 is involved in FDA esterolysis in these cells.	diacetylfluorescein	159-162	glutathione S-transferase pi 1	Homo sapiens	138-143
29310316-6	2018	Among the FDA derivatives examined, FOMe-Ac, the acetyl ester of fluorescein O-methyl ether, was found to be a potential reporter for GSH-dependent GSTP1 activity as well as for carboxylesterase activity.	diacetylfluorescein	10-13	glutathione S-transferase pi 1	Homo sapiens	148-153
29310316-6	2018	Among the FDA derivatives examined, FOMe-Ac, the acetyl ester of fluorescein O-methyl ether, was found to be a potential reporter for GSH-dependent GSTP1 activity as well as for carboxylesterase activity.	ethyl acetate	49-61	glutathione S-transferase pi 1	Homo sapiens	148-153
29310316-6	2018	Among the FDA derivatives examined, FOMe-Ac, the acetyl ester of fluorescein O-methyl ether, was found to be a potential reporter for GSH-dependent GSTP1 activity as well as for carboxylesterase activity.	fluorescein o-methyl ether	65-91	glutathione S-transferase pi 1	Homo sapiens	148-153
29310316-6	2018	Among the FDA derivatives examined, FOMe-Ac, the acetyl ester of fluorescein O-methyl ether, was found to be a potential reporter for GSH-dependent GSTP1 activity as well as for carboxylesterase activity.	Glutathione	134-137	glutathione S-transferase pi 1	Homo sapiens	148-153
29285015-2	2017	The missense substitution Ile105Val (rs1695) of the glutathione S-transferase P1 (GSTP1, OMIM: 134660) results from an A/G base substitution at nucleotide 313.	ile105val	26-35	glutathione S-transferase pi 1	Homo sapiens	52-80
29277760-3	2018	RESULTS: FS (2.5%) of raw and roasted hazelnuts reduced H2O2-induced DNA damage while 5% FS significantly induced gene expression of SOD2 (3.0-fold) and GSTP1 (2.1-fold).	Fluorine	9-11	glutathione S-transferase pi 1	Homo sapiens	153-158
29170472-6	2017	However, GSTP1 (A1578G) could reduce the risk of liver damage in populations exposed to low MC-LR levels alone or combined with high AFB1 levels.	cyanoginosin LR	92-97	glutathione S-transferase pi 1	Homo sapiens	9-14
30245524-0	2018	Voltammetric Application of Polypyrrole-Modified Microelectrode Array for the Characterization of DNA Methylation in Glutathione S-Transferase Pi 1.	polypyrrole	28-39	glutathione S-transferase pi 1	Homo sapiens	117-147
28748751-10	2018	Additionally, NTZ expresses inhibitory effect on the tumour cell progression by modulating drug detoxification (glutathione-S-transferase P1), unfolded protein response, autophagy, anti-cytokines activities and c-Myc inhibition.	nitazoxanide	14-17	glutathione S-transferase pi 1	Homo sapiens	112-140
28097896-0	2017	A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability.	nitrobenzoxadiazole	6-25	glutathione S-transferase pi 1	Homo sapiens	32-39
28097896-1	2017	CONTEXT: The nitrobezoxadiazole derivative NBDHEX is a potent inhibitor of glutathione transferase P1-1 (GSTP1-1) endowed with outstanding anticancer activity in different tumor models.	nitrobezoxadiazole	13-31	glutathione S-transferase pi 1	Homo sapiens	105-112
28097896-6	2017	DISCUSSION AND CONCLUSION: MC2753 may represent a lead compound for the development of novel GSTP1-1 inhibitors not affected in their anticancer action by fluctuations of cellular GSH levels, and characterized by an increased half-life in vivo.	mc2753	27-33	glutathione S-transferase pi 1	Homo sapiens	93-100
29170472-6	2017	However, GSTP1 (A1578G) could reduce the risk of liver damage in populations exposed to low MC-LR levels alone or combined with high AFB1 levels.	Aflatoxin B1	133-137	glutathione S-transferase pi 1	Homo sapiens	9-14
29170472-7	2017	In conclusion, SLCO1B1 (T521C) and GSTP1 (A1578G) are susceptible genes for liver damage in humans exposed to AFB1 and/or MC-LR in rural areas of China.	cyanoginosin LR	122-127	glutathione S-transferase pi 1	Homo sapiens	35-40
29285015-2	2017	The missense substitution Ile105Val (rs1695) of the glutathione S-transferase P1 (GSTP1, OMIM: 134660) results from an A/G base substitution at nucleotide 313.	ile105val	26-35	glutathione S-transferase pi 1	Homo sapiens	82-87
31966884-1	2017	This study was undertaken to detect the incidence of variations in exon 5 of GSTP1, a member of the glutathione-S-transferase family, in gastric cancer in relation to histological parameters.	Glutathione	100-111	glutathione S-transferase pi 1	Homo sapiens	77-82
28976264-0	2017	Epistatic interactions among CYP2C19*2, CYP3A4 and GSTP1 on the cyclophosphamide therapy in lupus nephritis patients.	Cyclophosphamide	64-80	glutathione S-transferase pi 1	Homo sapiens	51-56
28976264-1	2017	AIM: To investigate the impact of genetic variants in CYP2C9, CYP2C19, CYP3A4, GSTT1, GSTM1 and GSTP1 on the efficacy of cyclophosphamide (CYC) therapy in patients with lupus nephritis.	Cyclophosphamide	121-137	glutathione S-transferase pi 1	Homo sapiens	96-101
28976264-1	2017	AIM: To investigate the impact of genetic variants in CYP2C9, CYP2C19, CYP3A4, GSTT1, GSTM1 and GSTP1 on the efficacy of cyclophosphamide (CYC) therapy in patients with lupus nephritis.	Cyclophosphamide	139-142	glutathione S-transferase pi 1	Homo sapiens	96-101
29206502-0	2017	Synthesis and activity mechanism of some novel 2-substituted benzothiazoles as hGSTP1-1 enzyme inhibitors.	2-substituted benzothiazoles	47-75	glutathione S-transferase pi 1	Homo sapiens	79-85
29206502-3	2017	In this study, 12 benzothiazole derivatives were synthesized and screened for their in vitro inhibitory activity for hGSTP1-1.	benzothiazole	18-31	glutathione S-transferase pi 1	Homo sapiens	117-125
29206502-6	2017	In conclusion, it is observed that the lead compounds #2 and #5 possessed inhibitory activity on the hGSTP1-1 by binding to the H-site as a substrate in which the para position of the phenyl ring of the benzamide moiety on the benzothiazole ring is important.	benzamide	203-212	glutathione S-transferase pi 1	Homo sapiens	101-109
29206502-6	2017	In conclusion, it is observed that the lead compounds #2 and #5 possessed inhibitory activity on the hGSTP1-1 by binding to the H-site as a substrate in which the para position of the phenyl ring of the benzamide moiety on the benzothiazole ring is important.	benzothiazole	227-240	glutathione S-transferase pi 1	Homo sapiens	101-109
29066912-6	2017	The top hub genes AR, CDH13, CDKN2A, DAPK1, GSTP1, CD44 and RASSF1 identified from protein-protein interaction network construction using Search Tool for the Retrieval of Interacting Genes contributed to hormonal response, inflammatory response, cell cycle, reactive oxygen species activity and receptor kinase activity, which are related to hallmarks of cancer as revealed by their functional enrichment analysis by Cytoscape.	Reactive Oxygen Species	258-281	glutathione S-transferase pi 1	Homo sapiens	44-49
28947711-0	2017	Association of GSTM1, GSTT1 and GSTP1 Ile105Val polymorphisms with clinical response to imatinib mesylate treatment among Malaysian chronic myeloid leukaemia patients.	Imatinib Mesylate	88-105	glutathione S-transferase pi 1	Homo sapiens	32-37
28254657-5	2017	Eighty % reduction of intracellular glutathione (GSH) by buthionine sulfoximine (BSO), largely enhanced the sensitivity of the GSTP1 expressing MDA-MB-231 cells to HYP-PDT, but not in MCF7 cells.	Glutathione	36-47	glutathione S-transferase pi 1	Homo sapiens	127-132
28438694-3	2017	Glutathione S-transferase P1 (GSTP1), which belongs to the family of phase II metabolic enzymes, has been reported to function in detoxifying several anti-cancer drugs by conjugating them with glutathione.	Glutathione	193-204	glutathione S-transferase pi 1	Homo sapiens	0-28
28438694-3	2017	Glutathione S-transferase P1 (GSTP1), which belongs to the family of phase II metabolic enzymes, has been reported to function in detoxifying several anti-cancer drugs by conjugating them with glutathione.	Glutathione	193-204	glutathione S-transferase pi 1	Homo sapiens	30-35
28438694-5	2017	We have found that GSTP1 expression is much higher in adriamycin-resistant cells and their corresponding exosomes.	Doxorubicin	54-64	glutathione S-transferase pi 1	Homo sapiens	19-24
28438694-10	2017	After analysing the serum exosomes of 30 patients treated with anthracycline/taxane-based neoadjuvant chemotherapy, we discovered that the levels of GSTP1 in exosomes from patients in the PD/SD group were significantly higher than those in the PR/CR group.	Anthracyclines	63-76	glutathione S-transferase pi 1	Homo sapiens	149-154
28438694-10	2017	After analysing the serum exosomes of 30 patients treated with anthracycline/taxane-based neoadjuvant chemotherapy, we discovered that the levels of GSTP1 in exosomes from patients in the PD/SD group were significantly higher than those in the PR/CR group.	taxane	77-83	glutathione S-transferase pi 1	Homo sapiens	149-154
28438694-10	2017	After analysing the serum exosomes of 30 patients treated with anthracycline/taxane-based neoadjuvant chemotherapy, we discovered that the levels of GSTP1 in exosomes from patients in the PD/SD group were significantly higher than those in the PR/CR group.	Chromium	247-249	glutathione S-transferase pi 1	Homo sapiens	149-154
29130660-16	2017	In addition,in insufficient nutrition condition,when the HCT116 overexpress miR133b and GSTP1 at the same time,the extent of viability decrease and ROS level increase are shortened.	Reactive Oxygen Species	148-151	glutathione S-transferase pi 1	Homo sapiens	88-93
28254657-5	2017	Eighty % reduction of intracellular glutathione (GSH) by buthionine sulfoximine (BSO), largely enhanced the sensitivity of the GSTP1 expressing MDA-MB-231 cells to HYP-PDT, but not in MCF7 cells.	Glutathione	49-52	glutathione S-transferase pi 1	Homo sapiens	127-132
28254657-5	2017	Eighty % reduction of intracellular glutathione (GSH) by buthionine sulfoximine (BSO), largely enhanced the sensitivity of the GSTP1 expressing MDA-MB-231 cells to HYP-PDT, but not in MCF7 cells.	Buthionine Sulfoximine	57-79	glutathione S-transferase pi 1	Homo sapiens	127-132
28254657-5	2017	Eighty % reduction of intracellular glutathione (GSH) by buthionine sulfoximine (BSO), largely enhanced the sensitivity of the GSTP1 expressing MDA-MB-231 cells to HYP-PDT, but not in MCF7 cells.	Buthionine Sulfoximine	81-84	glutathione S-transferase pi 1	Homo sapiens	127-132
28254657-7	2017	HYP loading studies suggested that HYP can be a substrate of GSTP for GSH conjugation as BSO enhanced the cellular HYP accumulation by 20% in MDA-MB-231 cells, but not in MCF7 cells.	Glutathione	70-73	glutathione S-transferase pi 1	Homo sapiens	61-65
28254657-8	2017	Studies in solutions showed that L-cysteine can bind the GSTP substrate CDNB in the absence of GSTP.	Cysteine	33-43	glutathione S-transferase pi 1	Homo sapiens	57-61
28254657-8	2017	Studies in solutions showed that L-cysteine can bind the GSTP substrate CDNB in the absence of GSTP.	Dinitrochlorobenzene	72-76	glutathione S-transferase pi 1	Homo sapiens	57-61
28254657-9	2017	This means that the GSTP-lacking MCF7 may use L-cysteine for xenobiotic detoxification, especially during GSH synthesis inhibition, which leads to L-cysteine build-up.	Cysteine	46-56	glutathione S-transferase pi 1	Homo sapiens	20-24
28254657-9	2017	This means that the GSTP-lacking MCF7 may use L-cysteine for xenobiotic detoxification, especially during GSH synthesis inhibition, which leads to L-cysteine build-up.	Glutathione	106-109	glutathione S-transferase pi 1	Homo sapiens	20-24
28254657-9	2017	This means that the GSTP-lacking MCF7 may use L-cysteine for xenobiotic detoxification, especially during GSH synthesis inhibition, which leads to L-cysteine build-up.	Cysteine	147-157	glutathione S-transferase pi 1	Homo sapiens	20-24
28461312-6	2017	Therefore, we conclude that GSS, GSTP1, and ABCB5 proteins represent potential targets for enhancing the leishmanicidal activity of Glucantime.	Meglumine Antimoniate	132-142	glutathione S-transferase pi 1	Homo sapiens	33-38
28562019-6	2017	CBZ 10,11-epoxide (CBZE), a major electrophilic plasma metabolite of CBZ, formed adducts with glutathione-S-transferase pi (GSTP; Cys47) and human serum albumin (HSA; His146 and His338, but not Cys34) in vitro via notably divergent side-chain selectivity.	carbamazepine epoxide	0-17	glutathione S-transferase pi 1	Homo sapiens	94-122
28562019-6	2017	CBZ 10,11-epoxide (CBZE), a major electrophilic plasma metabolite of CBZ, formed adducts with glutathione-S-transferase pi (GSTP; Cys47) and human serum albumin (HSA; His146 and His338, but not Cys34) in vitro via notably divergent side-chain selectivity.	carbamazepine epoxide	0-17	glutathione S-transferase pi 1	Homo sapiens	124-128
28562019-6	2017	CBZ 10,11-epoxide (CBZE), a major electrophilic plasma metabolite of CBZ, formed adducts with glutathione-S-transferase pi (GSTP; Cys47) and human serum albumin (HSA; His146 and His338, but not Cys34) in vitro via notably divergent side-chain selectivity.	carbamazepine epoxide	19-23	glutathione S-transferase pi 1	Homo sapiens	94-122
28562019-6	2017	CBZ 10,11-epoxide (CBZE), a major electrophilic plasma metabolite of CBZ, formed adducts with glutathione-S-transferase pi (GSTP; Cys47) and human serum albumin (HSA; His146 and His338, but not Cys34) in vitro via notably divergent side-chain selectivity.	carbamazepine epoxide	19-23	glutathione S-transferase pi 1	Homo sapiens	124-128
28562019-6	2017	CBZ 10,11-epoxide (CBZE), a major electrophilic plasma metabolite of CBZ, formed adducts with glutathione-S-transferase pi (GSTP; Cys47) and human serum albumin (HSA; His146 and His338, but not Cys34) in vitro via notably divergent side-chain selectivity.	Carbamazepine	0-3	glutathione S-transferase pi 1	Homo sapiens	94-122
28562019-6	2017	CBZ 10,11-epoxide (CBZE), a major electrophilic plasma metabolite of CBZ, formed adducts with glutathione-S-transferase pi (GSTP; Cys47) and human serum albumin (HSA; His146 and His338, but not Cys34) in vitro via notably divergent side-chain selectivity.	Carbamazepine	0-3	glutathione S-transferase pi 1	Homo sapiens	124-128
28747791-5	2017	We then synthesized the fluorogenic probe, DNAT-Me, which is fluorescently quenched but is activated by GSTP1-1.	DNAT-Me	43-50	glutathione S-transferase pi 1	Homo sapiens	104-111
28692125-8	2017	Our results suggest that wild-type GSTP1 or CYP17 genes when combined with LOH/MSI in steroid metabolism genes may play a role in ER and/or PR negative breast cancers.	Steroids	86-93	glutathione S-transferase pi 1	Homo sapiens	35-40
28572675-1	2017	The influences of glutathione s-transferase P1, M1, and T1 variants on the efficacy of platinum-based chemotherapy in non-small cell lung cancer (NSCLC) patients were inconsistent in previous studies.	Platinum	87-95	glutathione S-transferase pi 1	Homo sapiens	18-46
28478157-6	2017	The results showed that GSTP1-1, GSTA4-4, GSTM4-4, GSTM2-2 and GSTA2-2 (activity in decreasing order) were active isoforms in catalyzing GSH conjugation of reactive QIs of AQ and DEAQ.	Glutathione	137-140	glutathione S-transferase pi 1	Homo sapiens	24-31
28478157-6	2017	The results showed that GSTP1-1, GSTA4-4, GSTM4-4, GSTM2-2 and GSTA2-2 (activity in decreasing order) were active isoforms in catalyzing GSH conjugation of reactive QIs of AQ and DEAQ.	Amodiaquine	172-174	glutathione S-transferase pi 1	Homo sapiens	24-31
28478157-6	2017	The results showed that GSTP1-1, GSTA4-4, GSTM4-4, GSTM2-2 and GSTA2-2 (activity in decreasing order) were active isoforms in catalyzing GSH conjugation of reactive QIs of AQ and DEAQ.	desethylamodiaquine	179-183	glutathione S-transferase pi 1	Homo sapiens	24-31
28572675-6	2017	Our meta-analysis suggested that the GSTP1 IIe105Val, GSTM1 and GSTT1 null variants might be predictive factors for the efficacy of platinum-based chemotherapy to NSCLC patients.	Platinum	132-140	glutathione S-transferase pi 1	Homo sapiens	37-42
28572675-7	2017	The use of GSTP1 IIe105Val, GSTM1 and GSTT1 null polymorphisms as predictive factors of efficacy of personalized platinum-based chemotherapy to NSCLC patients requires further verification with multi-center, multi-ethnic and large-sample-size pharmacogenetic studies.	Platinum	113-121	glutathione S-transferase pi 1	Homo sapiens	11-16
28288932-2	2017	Moreover, signaling by PKA/cAMP response element binding protein (CREB) is necessary for GSTP up-regulation.	Cyclic AMP	27-31	glutathione S-transferase pi 1	Homo sapiens	89-93
28184905-3	2017	A role for human GSTP1 in MeHg disposition is suggested by the association of two common polymorphisms in the coding region (Ile105Val and Ala114Val) with Hg levels in either blood or hair.	ile105val	125-134	glutathione S-transferase pi 1	Homo sapiens	17-22
28219722-0	2017	Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1.	Nitric Oxide	26-38	glutathione S-transferase pi 1	Homo sapiens	146-151
28219722-1	2017	We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-MO) models from large quantities of endogenous NO.	Nitric Oxide	74-86	glutathione S-transferase pi 1	Homo sapiens	104-132
28219722-1	2017	We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-MO) models from large quantities of endogenous NO.	Nitric Oxide	74-86	glutathione S-transferase pi 1	Homo sapiens	134-139
28288932-3	2017	This study explored whether carnosic acid (CA) from rosemary prevents 6-hydroxydopamine (6-OHDA)-induced neurotoxicity by inhibition of JNK through GSTP via PKA/CREB signaling.	salvin	28-41	glutathione S-transferase pi 1	Homo sapiens	148-152
28288932-8	2017	Pretreatment with H89 and GSTP siRNA attenuated the ability of CA to reverse 6-OHDA-induced apoptosis.	Oxidopamine	77-83	glutathione S-transferase pi 1	Homo sapiens	26-30
28288932-9	2017	By use of immunoprecipitation with JNK antibody to examine the interaction of GSTP-JNK with CA, we showed that CA pretreatment increased the immunoprecipitation of GSTP after 6-OHDA treatment, which suggests that CA promoted the interaction between GSTP and JNK.	Oxidopamine	175-181	glutathione S-transferase pi 1	Homo sapiens	78-82
28288932-9	2017	By use of immunoprecipitation with JNK antibody to examine the interaction of GSTP-JNK with CA, we showed that CA pretreatment increased the immunoprecipitation of GSTP after 6-OHDA treatment, which suggests that CA promoted the interaction between GSTP and JNK.	Oxidopamine	175-181	glutathione S-transferase pi 1	Homo sapiens	164-168
28288932-9	2017	By use of immunoprecipitation with JNK antibody to examine the interaction of GSTP-JNK with CA, we showed that CA pretreatment increased the immunoprecipitation of GSTP after 6-OHDA treatment, which suggests that CA promoted the interaction between GSTP and JNK.	Oxidopamine	175-181	glutathione S-transferase pi 1	Homo sapiens	164-168
28288932-10	2017	CONCLUSION: CA prevents 6-OHDA-induced apoptosis via inhibition of JNK by GSTP through the PKA/CREB pathway.	Oxidopamine	24-30	glutathione S-transferase pi 1	Homo sapiens	74-78
28153749-2	2017	A single nucleotide polymorphism (SNP) i.e. Ile105Val (rs1695) in glutathione S-transferase P1 (GSTP1) gene influences cytological toxicity and modulates the risk to occupational diseases.	ile105val	44-53	glutathione S-transferase pi 1	Homo sapiens	66-94
28442702-7	2017	CONCLUSIONS Polymorphisms of GSTP1 rs1695 and ABCC2 rs717620 can be used to predict the outcomes of Uygur patients with advanced NSCLC who have received platinum-based chemotherapy.	Platinum	153-161	glutathione S-transferase pi 1	Homo sapiens	29-34
28153749-2	2017	A single nucleotide polymorphism (SNP) i.e. Ile105Val (rs1695) in glutathione S-transferase P1 (GSTP1) gene influences cytological toxicity and modulates the risk to occupational diseases.	ile105val	44-53	glutathione S-transferase pi 1	Homo sapiens	96-101
28198496-8	2017	Moreover, the Val allele of GSTP1 was associated with higher susceptibility to gastric cancer as compared with the Ile allele (OR = 1.52, 95%CI = 1.19-1.93).	Valine	14-17	glutathione S-transferase pi 1	Homo sapiens	28-33
27913949-0	2017	Epigenetic CpG Methylation of the Promoter and Reactivation of the Expression of GSTP1 by Astaxanthin in Human Prostate LNCaP Cells.	astaxanthine	90-101	glutathione S-transferase pi 1	Homo sapiens	81-86
28208751-9	2017	Children with the GSTP1 (rs1695) AA and SOD2 (rs5746136) TT genotypes had higher MEHHP levels as compared to GG and CC types, respectively.	mono(2-ethyl-5-hydroxyhexyl) phthalate	81-86	glutathione S-transferase pi 1	Homo sapiens	18-23
28208751-11	2017	As MEHHP concentrations were dependent on GSTP1 and SOD2, but the assessment of interaction requires independent variables, we estimated MEHHP residuals and assessed their interaction, showing that the OR for SOD2 TT was further elevated to 3.32 (1.75-6.32) when the residuals of MEHHP were high.	mono(2-ethyl-5-hydroxyhexyl) phthalate	3-8	glutathione S-transferase pi 1	Homo sapiens	42-47
27348130-2	2017	Pi-class glutathione-S-transferase (GSTP1) plays a role in the removal of oxidative adducts by transferring them to glutathione.	Glutathione	9-20	glutathione S-transferase pi 1	Homo sapiens	36-41
27348130-8	2017	To assess the effect of DNA methylation on the mRNA expression of GSTP1, human lens epithelium HLE-B3 cells were treated with the demethylation compound 5-aza-dC, followed by qRT-PCR assay.	Decitabine	153-161	glutathione S-transferase pi 1	Homo sapiens	66-71
27348130-15	2017	Demethylation treatment of HLE-B3 cells with 5-aza-dC enhanced the expression of GSTP1.	Decitabine	45-53	glutathione S-transferase pi 1	Homo sapiens	81-86
28062686-7	2017	These observations could support the hypothesis that the GSTP1 G allele may improve exercise performance by better elimination of exercise-induced ROS.	ros	147-150	glutathione S-transferase pi 1	Homo sapiens	57-62
28222671-0	2017	Reversal of hypermethylation and reactivation of glutathione S-transferase pi 1 gene by curcumin in breast cancer cell line.	Curcumin	88-96	glutathione S-transferase pi 1	Homo sapiens	49-79
27863446-3	2017	Here we describe using crystallography, X-ray absorption spectroscopy, mutagenesis, mass spectrometry, and kinetic studies how GSTP1-1 recognizes the drug phenylarsine oxide (PAO).	oxophenylarsine	155-173	glutathione S-transferase pi 1	Homo sapiens	127-134
27863446-3	2017	Here we describe using crystallography, X-ray absorption spectroscopy, mutagenesis, mass spectrometry, and kinetic studies how GSTP1-1 recognizes the drug phenylarsine oxide (PAO).	oxophenylarsine	175-178	glutathione S-transferase pi 1	Homo sapiens	127-134
27863446-6	2017	In summary, GSTP1-1 can detoxify arsenic-based drugs by sequestration at the active site and at the dimer interface, in situations where there is a plentiful supply of GSH, and at the reactive cysteines in conditions of low GSH.	Arsenic	33-40	glutathione S-transferase pi 1	Homo sapiens	12-19
27863446-6	2017	In summary, GSTP1-1 can detoxify arsenic-based drugs by sequestration at the active site and at the dimer interface, in situations where there is a plentiful supply of GSH, and at the reactive cysteines in conditions of low GSH.	Glutathione	168-171	glutathione S-transferase pi 1	Homo sapiens	12-19
27863446-6	2017	In summary, GSTP1-1 can detoxify arsenic-based drugs by sequestration at the active site and at the dimer interface, in situations where there is a plentiful supply of GSH, and at the reactive cysteines in conditions of low GSH.	Cysteine	193-202	glutathione S-transferase pi 1	Homo sapiens	12-19
27863446-6	2017	In summary, GSTP1-1 can detoxify arsenic-based drugs by sequestration at the active site and at the dimer interface, in situations where there is a plentiful supply of GSH, and at the reactive cysteines in conditions of low GSH.	Glutathione	224-227	glutathione S-transferase pi 1	Homo sapiens	12-19
27277477-7	2017	RESULTS AND LIMITATIONS: Seven SNPs located in or nearby genes implicated in steroid hormone metabolism were significantly associated with prostate volume: HSD17B2 (rs1119933), ESR2 (rs8006145), SULT2B1 (rs279451), NQO1 (rs2917670), ESR1 (rs1569788), GSTP1 (rs1138272), and CYP19A1 (rs17523880).	Steroids	77-92	glutathione S-transferase pi 1	Homo sapiens	251-256
28222671-6	2017	To check the effect of curcumin on the methylation pattern of glutathione S-transferase pi 1 gene in MCF-7 breast cancer cell line in dose-dependent manner.	Curcumin	23-31	glutathione S-transferase pi 1	Homo sapiens	62-92
28222671-7	2017	To check the reversal of methylation pattern of hypermethylated glutathione S-transferase pi 1, MCF-7 breast cancer cell line was treated with different concentrations of curcumin for different time periods.	Curcumin	171-179	glutathione S-transferase pi 1	Homo sapiens	64-94
28222671-9	2017	A very low and a nontoxic concentration (10 microM) of curcumin treatment was able to reverse the hypermethylation and led to reactivation of glutathione S-transferase pi 1 protein expression in MCF-7 cells after 72 h of treatment, although the IC50 value of curcumin was found to be at 20 microM.	Curcumin	55-63	glutathione S-transferase pi 1	Homo sapiens	142-172
28222671-11	2017	Treatment of breast cancer MCF-7 cells with curcumin causes complete reversal of glutathione S-transferase pi 1 promoter hypermethylation and leads to re-expression of glutathione S-transferase pi 1, suggesting it to be an excellent nontoxic hypomethylating agent.	Curcumin	44-52	glutathione S-transferase pi 1	Homo sapiens	81-111
28222671-11	2017	Treatment of breast cancer MCF-7 cells with curcumin causes complete reversal of glutathione S-transferase pi 1 promoter hypermethylation and leads to re-expression of glutathione S-transferase pi 1, suggesting it to be an excellent nontoxic hypomethylating agent.	Curcumin	44-52	glutathione S-transferase pi 1	Homo sapiens	168-198
29435433-7	2017	To determine the polymorphisms of GSTP1 in exon 5 (Ile105Val) and exon 6 (Ala114Val), RFLP-PCR method was performed.	ile105val	51-60	glutathione S-transferase pi 1	Homo sapiens	34-39
27872191-0	2017	Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine.	piperlonguminine	130-144	glutathione S-transferase pi 1	Homo sapiens	60-90
27872191-1	2017	Glutathione S-transferase pi 1 (GSTP1) is frequently overexpressed in cancerous tumors and is a putative target of the plant compound piperlongumine (PL), which contains two reactive olefins and inhibits proliferation in cancer cells but not normal cells.	piperlonguminine	134-148	glutathione S-transferase pi 1	Homo sapiens	0-30
27872191-1	2017	Glutathione S-transferase pi 1 (GSTP1) is frequently overexpressed in cancerous tumors and is a putative target of the plant compound piperlongumine (PL), which contains two reactive olefins and inhibits proliferation in cancer cells but not normal cells.	piperlonguminine	134-148	glutathione S-transferase pi 1	Homo sapiens	32-37
27872191-1	2017	Glutathione S-transferase pi 1 (GSTP1) is frequently overexpressed in cancerous tumors and is a putative target of the plant compound piperlongumine (PL), which contains two reactive olefins and inhibits proliferation in cancer cells but not normal cells.	Alkenes	183-190	glutathione S-transferase pi 1	Homo sapiens	0-30
27872191-1	2017	Glutathione S-transferase pi 1 (GSTP1) is frequently overexpressed in cancerous tumors and is a putative target of the plant compound piperlongumine (PL), which contains two reactive olefins and inhibits proliferation in cancer cells but not normal cells.	Alkenes	183-190	glutathione S-transferase pi 1	Homo sapiens	32-37
27872191-3	2017	These data in tandem with other information led to the conclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the C2-C3 olefin of PL was postulated to react with GSH.	Glutathione	125-128	glutathione S-transferase pi 1	Homo sapiens	83-88
27872191-3	2017	These data in tandem with other information led to the conclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the C2-C3 olefin of PL was postulated to react with GSH.	Alkenes	213-219	glutathione S-transferase pi 1	Homo sapiens	83-88
27872191-3	2017	These data in tandem with other information led to the conclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the C2-C3 olefin of PL was postulated to react with GSH.	Alkenes	245-251	glutathione S-transferase pi 1	Homo sapiens	83-88
27872191-3	2017	These data in tandem with other information led to the conclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the C2-C3 olefin of PL was postulated to react with GSH.	Glutathione	287-290	glutathione S-transferase pi 1	Homo sapiens	83-88
27872191-5	2017	To investigate, we solved the X-ray crystal structure of GSTP1 bound to PL and GSH at 1.1 A resolution to rationalize previously reported structure activity relationship studies.	Glutathione	79-82	glutathione S-transferase pi 1	Homo sapiens	57-62
27872191-6	2017	Surprisingly, the structure showed that a hydrolysis product of PL (hPL) was conjugated to glutathione at the C7-C8 olefin, and this complex was bound to the active site of GSTP1; no covalent bond formation between hPL and GSTP1 was observed.	Glutathione	91-102	glutathione S-transferase pi 1	Homo sapiens	173-178
27872191-6	2017	Surprisingly, the structure showed that a hydrolysis product of PL (hPL) was conjugated to glutathione at the C7-C8 olefin, and this complex was bound to the active site of GSTP1; no covalent bond formation between hPL and GSTP1 was observed.	Glutathione	91-102	glutathione S-transferase pi 1	Homo sapiens	223-228
27872191-6	2017	Surprisingly, the structure showed that a hydrolysis product of PL (hPL) was conjugated to glutathione at the C7-C8 olefin, and this complex was bound to the active site of GSTP1; no covalent bond formation between hPL and GSTP1 was observed.	Alkenes	116-122	glutathione S-transferase pi 1	Homo sapiens	173-178
27872191-10	2017	Altogether, our data suggest a model wherein PL is a prodrug whose intracellular hydrolysis initiates the formation of the hPL-GSH conjugate, which blocks the active site of and inhibits GSTP1 and thereby cancer cell proliferation.	Glutathione	127-130	glutathione S-transferase pi 1	Homo sapiens	187-192
28550240-10	2017	RESULTS: In patients with GSTP1 AA genotype we have found significance level reaching plasma concentration rise in SOD and MDA, and drop in GSH, SH.	Glutathione	140-143	glutathione S-transferase pi 1	Homo sapiens	26-31
27815499-2	2016	Negative cooperativity occurs in human glutathione transferase (GST) GSTP1-1 when it binds and neutralizes a toxic nitric oxide adduct, the dinitrosyl-diglutathionyl iron complex (DNDGIC).	Nitric Oxide	115-127	glutathione S-transferase pi 1	Homo sapiens	69-76
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	dinitrosyl-dithiol	107-125	glutathione S-transferase pi 1	Homo sapiens	53-81
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	dinitrosyl-dithiol	107-125	glutathione S-transferase pi 1	Homo sapiens	83-88
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	Iron	126-130	glutathione S-transferase pi 1	Homo sapiens	53-81
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	Iron	126-130	glutathione S-transferase pi 1	Homo sapiens	83-88
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	Iron	174-178	glutathione S-transferase pi 1	Homo sapiens	53-81
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	Iron	174-178	glutathione S-transferase pi 1	Homo sapiens	83-88
27866158-10	2016	This was confirmed by silencing nuclear factor-erythroid 2-related factor 2 (Nrf2), which decreased MRP1 and GSTP1 expression, concomitant with reduced 59Fe release and macrophage survival.	Iron-59	152-156	glutathione S-transferase pi 1	Homo sapiens	109-114
27815499-2	2016	Negative cooperativity occurs in human glutathione transferase (GST) GSTP1-1 when it binds and neutralizes a toxic nitric oxide adduct, the dinitrosyl-diglutathionyl iron complex (DNDGIC).	dinitrosyl diglutathionyl iron	140-170	glutathione S-transferase pi 1	Homo sapiens	69-76
27704276-6	2016	siRNA-mediated knockdown of AKR1B8 and GSTP1 inhibit DHA-induced apoptosis confirming their role in apoptotic process.	Docosahexaenoic Acids	53-56	glutathione S-transferase pi 1	Homo sapiens	39-44
27989146-5	2016	The results show that GSTP1-1 is a highly active catalyst of GSH-conjugation of the oxidative metabolites of NVP, even at high GSH-concentration.	Glutathione	61-64	glutathione S-transferase pi 1	Homo sapiens	22-29
27989146-5	2016	The results show that GSTP1-1 is a highly active catalyst of GSH-conjugation of the oxidative metabolites of NVP, even at high GSH-concentration.	Glutathione	127-130	glutathione S-transferase pi 1	Homo sapiens	22-29
27785604-12	2016	And the heterogeneity present in different studies, evaluating the association of GSTP1 polymorphism with response to anthracycline-based chemotherapy, disappeared in breast cancer patients after subgroup analysis by chemotherapy regimen was performed.	Anthracyclines	118-131	glutathione S-transferase pi 1	Homo sapiens	82-87
27785604-13	2016	In conclusion, this meta-analysis suggested that GSTP1rs1695 and GSTM1-present/GSTM1-null polymorphisms could be considered as reliable predictors of response to anthracycline-based chemotherapy in patients with breast cancer.	Anthracyclines	162-175	glutathione S-transferase pi 1	Homo sapiens	49-54
27684484-5	2016	Here, we report the crystal structures of hGSTP1 and hGSTA1 each in complex with the GSH adduct of PEITC.	Glutathione	85-88	glutathione S-transferase pi 1	Homo sapiens	42-48
27749250-5	2016	Treatment by rutin significantly inhibited protein expressions of cytochrome P450-dependent CYP3A4 (75.3 %, p < 0.0001), elevated CYP1A1 enzymes (1.7-fold, p = 0.0084) and increased protein expressions of antioxidant and phase II reaction catalyzing enzymes, NQO1 (2.42-fold, p < 0.0001) and GSTP1 (2.03-fold, p < 0.0001).	Rutin	13-18	glutathione S-transferase pi 1	Homo sapiens	298-303
27834815-9	2016	Our findings indicate that ASD status may be a potential effect modifier when assessing the association between GSTP1 rs1695 and blood aluminum concentrations among Jamaican children.	Aluminum	135-143	glutathione S-transferase pi 1	Homo sapiens	112-117
27729156-8	2016	RESULTS: According to univariate analyses, male gender, co-treatment with aminoglycosides and mutant genotype of GSTP1 rs1695 were significantly related with cisplatin ototoxicity.	Cisplatin	158-167	glutathione S-transferase pi 1	Homo sapiens	113-118
26329912-0	2016	Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione.	nitrobenzoxadiazole	0-19	glutathione S-transferase pi 1	Homo sapiens	26-33
26329912-0	2016	Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione.	(pseudo)glutathione	84-103	glutathione S-transferase pi 1	Homo sapiens	26-33
27544755-8	2016	It inhibited nuclear factor erythroid 2-related factor 2 and glutathione S-transferase P in cisplatin-resistant HNC cells, resulting in increased ROS accumulation in HNC cells, an effect that could be blocked by the antioxidant N-acetyl-L-cysteine.	Cisplatin	92-101	glutathione S-transferase pi 1	Homo sapiens	61-88
27544755-8	2016	It inhibited nuclear factor erythroid 2-related factor 2 and glutathione S-transferase P in cisplatin-resistant HNC cells, resulting in increased ROS accumulation in HNC cells, an effect that could be blocked by the antioxidant N-acetyl-L-cysteine.	Acetylcysteine	228-247	glutathione S-transferase pi 1	Homo sapiens	61-88
27058114-10	2016	TLK117, an isotype-selective inhibitor of GSTP, also enhanced LPS-induced NF-kappaB transcriptional activity and pro-inflammatory cytokine production, suggesting that the catalytic activity of GSTP is important in repressing NF-kappaB activation.	gamma-Glu-S-BzCys-PhGly diethyl ester	0-6	glutathione S-transferase pi 1	Homo sapiens	42-46
27385593-7	2016	GSTP1 genotype frequencies of patients and control cases were found to be 55% (Ile105Ile), 43.4% (Ile105Val), and 1.6% (Val105Val) and 75.6% (Ile105Ile), 22% (Ile105Val), and 2.4% (Val105Val), respectively.	ile105ile	79-88	glutathione S-transferase pi 1	Homo sapiens	0-5
27385593-7	2016	GSTP1 genotype frequencies of patients and control cases were found to be 55% (Ile105Ile), 43.4% (Ile105Val), and 1.6% (Val105Val) and 75.6% (Ile105Ile), 22% (Ile105Val), and 2.4% (Val105Val), respectively.	ile105val	98-107	glutathione S-transferase pi 1	Homo sapiens	0-5
27385593-7	2016	GSTP1 genotype frequencies of patients and control cases were found to be 55% (Ile105Ile), 43.4% (Ile105Val), and 1.6% (Val105Val) and 75.6% (Ile105Ile), 22% (Ile105Val), and 2.4% (Val105Val), respectively.	ile105ile	142-151	glutathione S-transferase pi 1	Homo sapiens	0-5
27385593-7	2016	GSTP1 genotype frequencies of patients and control cases were found to be 55% (Ile105Ile), 43.4% (Ile105Val), and 1.6% (Val105Val) and 75.6% (Ile105Ile), 22% (Ile105Val), and 2.4% (Val105Val), respectively.	ile105val	159-168	glutathione S-transferase pi 1	Homo sapiens	0-5
27368697-2	2016	Glutathione S-transferases (GSTs) are a family of antioxidant enzymes that play important roles in decreasing ROS species and act as a kind of antioxidant defense.	ros	110-113	glutathione S-transferase pi 1	Homo sapiens	28-32
27058114-10	2016	TLK117, an isotype-selective inhibitor of GSTP, also enhanced LPS-induced NF-kappaB transcriptional activity and pro-inflammatory cytokine production, suggesting that the catalytic activity of GSTP is important in repressing NF-kappaB activation.	gamma-Glu-S-BzCys-PhGly diethyl ester	0-6	glutathione S-transferase pi 1	Homo sapiens	193-197
27156773-1	2016	Ethacrynic acid (EA), a known inhibitor of the neoplastic marker glutathione S-transferase P1 and other GSTs, exerts a weak antiproliferative activity against human cancer cells.	Ethacrynic Acid	0-15	glutathione S-transferase pi 1	Homo sapiens	65-93
26768611-8	2016	The risk of gastric cancer was significantly elevated in individuals with XRCC1 Arg/Gln +Gln/Gln (p = 0.031; odds ratio = 2.32; 95 % confidence interval (CI) 1.07-5.06) and GSTP1 Val/Val genotype (p = 0.009; odds ratio = 8.64; 95 % CI 1.84-40.55).	Arginine	80-83	glutathione S-transferase pi 1	Homo sapiens	173-178
26768611-8	2016	The risk of gastric cancer was significantly elevated in individuals with XRCC1 Arg/Gln +Gln/Gln (p = 0.031; odds ratio = 2.32; 95 % confidence interval (CI) 1.07-5.06) and GSTP1 Val/Val genotype (p = 0.009; odds ratio = 8.64; 95 % CI 1.84-40.55).	Glutamine	84-87	glutathione S-transferase pi 1	Homo sapiens	173-178
26768611-8	2016	The risk of gastric cancer was significantly elevated in individuals with XRCC1 Arg/Gln +Gln/Gln (p = 0.031; odds ratio = 2.32; 95 % confidence interval (CI) 1.07-5.06) and GSTP1 Val/Val genotype (p = 0.009; odds ratio = 8.64; 95 % CI 1.84-40.55).	Glutamine	89-92	glutathione S-transferase pi 1	Homo sapiens	173-178
26768611-8	2016	The risk of gastric cancer was significantly elevated in individuals with XRCC1 Arg/Gln +Gln/Gln (p = 0.031; odds ratio = 2.32; 95 % confidence interval (CI) 1.07-5.06) and GSTP1 Val/Val genotype (p = 0.009; odds ratio = 8.64; 95 % CI 1.84-40.55).	Glutamine	89-92	glutathione S-transferase pi 1	Homo sapiens	173-178
26768611-9	2016	An elevated risk for GC was observed in smokers and alcohol consumers carrying GSTP1 Ile/Val +Val/Val genotype (p = 0.041; odds ratio = 3.71; 95 % CI 0.98-14.12; p = 0.002; odds ratio = 12.31; 95 % CI 1.71-88.59).	Alcohols	52-59	glutathione S-transferase pi 1	Homo sapiens	79-84
27156773-1	2016	Ethacrynic acid (EA), a known inhibitor of the neoplastic marker glutathione S-transferase P1 and other GSTs, exerts a weak antiproliferative activity against human cancer cells.	Ethacrynic Acid	0-15	glutathione S-transferase pi 1	Homo sapiens	104-108
27156773-1	2016	Ethacrynic acid (EA), a known inhibitor of the neoplastic marker glutathione S-transferase P1 and other GSTs, exerts a weak antiproliferative activity against human cancer cells.	Ethacrynic Acid	17-19	glutathione S-transferase pi 1	Homo sapiens	65-93
27156773-1	2016	Ethacrynic acid (EA), a known inhibitor of the neoplastic marker glutathione S-transferase P1 and other GSTs, exerts a weak antiproliferative activity against human cancer cells.	Ethacrynic Acid	17-19	glutathione S-transferase pi 1	Homo sapiens	104-108
27093577-8	2016	DNS-DOX, however, effectively killed GSTP1 (20 nmol/min/mg) and MGST1 (450 nmol/min/mg) overexpressing cells as did the less reactive 4-mononitrobenzenesulfonyl doxorubicin (MNS-DOX) in a MGST1-dependent manner (1.5 nmol/min/mg) as shown previously.	dns-dox	0-7	glutathione S-transferase pi 1	Homo sapiens	37-42
27113863-5	2016	Furthermore, the levels of GSTO1-1 and GSTP1-1 activity were examined using S-(4-nitrophenacyl)glutathione and ethacrynic acid, respectively, as the specific substrates.	S-(4-nitrophenacyl)glutathione	76-106	glutathione S-transferase pi 1	Homo sapiens	39-46
27113863-5	2016	Furthermore, the levels of GSTO1-1 and GSTP1-1 activity were examined using S-(4-nitrophenacyl)glutathione and ethacrynic acid, respectively, as the specific substrates.	Ethacrynic Acid	111-126	glutathione S-transferase pi 1	Homo sapiens	39-46
27366093-3	2016	Numerous studies have been performed to investigate the association between GSTP1 Ile105Val (rs1695 A>G) polymorphism and urinary system cancer risk.	ile105val	82-91	glutathione S-transferase pi 1	Homo sapiens	76-81
27113843-0	2016	A tyrosine-reactive irreversible inhibitor for glutathione S-transferase Pi (GSTP1).	Tyrosine	2-10	glutathione S-transferase pi 1	Homo sapiens	77-82
27323109-0	2016	GSTP1 Ile105Val and XRCC1 Arg399Gln gene polymorphisms contribute to the clinical outcome of patients with advanced non-small cell lung cancer.	ile105val	6-15	glutathione S-transferase pi 1	Homo sapiens	0-5
27323109-7	2016	In summary, we suggest that GSTP1 Ile105Val and XRCC1 Arg399Gln polymorphisms could influence the response to chemotherapy and sur-vival of advanced NSCLC.	ile105val	34-43	glutathione S-transferase pi 1	Homo sapiens	28-33
27358914-4	2016	S-glutathionylation, the conjugation of glutathione to reactive cysteines, is catalyzed in part by glutathione-S-transferase pi (GSTP).	Glutathione	40-51	glutathione S-transferase pi 1	Homo sapiens	129-133
27358914-4	2016	S-glutathionylation, the conjugation of glutathione to reactive cysteines, is catalyzed in part by glutathione-S-transferase pi (GSTP).	Cysteine	64-73	glutathione S-transferase pi 1	Homo sapiens	129-133
27358914-8	2016	The FAS-GSTP interaction was also increased in IPF lungs.	ammonium ferrous sulfate	4-7	glutathione S-transferase pi 1	Homo sapiens	8-12
27358914-9	2016	Bleomycin- and AdTGFbeta-induced increases in collagen content, alpha-SMA, FAS S-glutathionylation, and total protein S-glutathionylation were strongly attenuated in Gstp-/- mice.	Bleomycin	0-9	glutathione S-transferase pi 1	Homo sapiens	166-170
27358914-10	2016	Oropharyngeal administration of the GSTP inhibitor, TLK117, at a time when fibrosis was already apparent, attenuated bleomycin- and AdTGFbeta-induced remodeling, alpha-SMA, caspase activation, FAS S-glutathionylation, and total protein S-glutathionylation.	gamma-Glu-S-BzCys-PhGly diethyl ester	52-58	glutathione S-transferase pi 1	Homo sapiens	36-40
27358914-10	2016	Oropharyngeal administration of the GSTP inhibitor, TLK117, at a time when fibrosis was already apparent, attenuated bleomycin- and AdTGFbeta-induced remodeling, alpha-SMA, caspase activation, FAS S-glutathionylation, and total protein S-glutathionylation.	Bleomycin	117-126	glutathione S-transferase pi 1	Homo sapiens	36-40
27113843-2	2016	Here, we report LAS17, a dichlorotriazine-containing compound that irreversibly inhibits GSTP1 and is selective for GSTP1 within cellular proteomes.	LAS17	16-21	glutathione S-transferase pi 1	Homo sapiens	89-94
27113843-2	2016	Here, we report LAS17, a dichlorotriazine-containing compound that irreversibly inhibits GSTP1 and is selective for GSTP1 within cellular proteomes.	LAS17	16-21	glutathione S-transferase pi 1	Homo sapiens	116-121
27113843-2	2016	Here, we report LAS17, a dichlorotriazine-containing compound that irreversibly inhibits GSTP1 and is selective for GSTP1 within cellular proteomes.	dichlorotriazine	25-41	glutathione S-transferase pi 1	Homo sapiens	89-94
27113843-2	2016	Here, we report LAS17, a dichlorotriazine-containing compound that irreversibly inhibits GSTP1 and is selective for GSTP1 within cellular proteomes.	dichlorotriazine	25-41	glutathione S-transferase pi 1	Homo sapiens	116-121
27193186-7	2016	Quantitative proteomics analysis indicated that six NRF2-targeted proteins, including NQO1, GSR, G6PD, GCLC, GCLM and GSTP1 involved in the glutathione metabolism pathway, were reduced in H19-knockdown cells.	Glutathione	140-151	glutathione S-transferase pi 1	Homo sapiens	118-123
27197232-10	2016	Tumors exhibited increased antioxidant metabolites and upregulation of glutathione S-transferase pathway genes, including Gstp1 and Gstz1, which are associated with poor outcome in human neuroblastoma.	Glutathione	71-82	glutathione S-transferase pi 1	Homo sapiens	122-127
26970057-7	2016	Significant association was also detected between MRP1A(-)/GSTP1Val(-) genotypes and urinary arsenic levels (p=0.001).	Arsenic	93-100	glutathione S-transferase pi 1	Homo sapiens	59-64
27179909-3	2016	Genetic polymorphisms in CYP2E1, GSTA1 and GSTP1 genes, affecting enzymes activity, may possibly influence the hepatotoxic effect of sevoflurane.	Sevoflurane	133-144	glutathione S-transferase pi 1	Homo sapiens	43-48
27179909-12	2016	CONCLUSIONS: GSTP1 gene polymorphism has an impact on the perioperative serum alpha-GST concentration in patients undergoing sevoflurane anaesthesia.	Sevoflurane	125-136	glutathione S-transferase pi 1	Homo sapiens	13-18
27037874-5	2016	It is anticipated that when GSH analogues with selective inhibitory or catalytic binding, were conjugated to allozyme-selective inhibitors of hGSTP1-1, the derived leads would be useful for the designing of novel chimeric inhibitors against the MDR-involved hGSTP1-1 allozymes.	Glutathione	28-31	glutathione S-transferase pi 1	Homo sapiens	142-150
27037874-5	2016	It is anticipated that when GSH analogues with selective inhibitory or catalytic binding, were conjugated to allozyme-selective inhibitors of hGSTP1-1, the derived leads would be useful for the designing of novel chimeric inhibitors against the MDR-involved hGSTP1-1 allozymes.	Glutathione	28-31	glutathione S-transferase pi 1	Homo sapiens	258-266
26922696-1	2016	Glutathione S-transferase P (GSTP), and possibly other members of the subfamily of cytosolic GSTs, are increasingly proposed to have roles far beyond the classical GSH-dependent enzymatic detoxification of electrophilic metabolites and xenobiotics.	Glutathione	164-167	glutathione S-transferase pi 1	Homo sapiens	0-27
26922696-1	2016	Glutathione S-transferase P (GSTP), and possibly other members of the subfamily of cytosolic GSTs, are increasingly proposed to have roles far beyond the classical GSH-dependent enzymatic detoxification of electrophilic metabolites and xenobiotics.	Glutathione	164-167	glutathione S-transferase pi 1	Homo sapiens	29-33
26922696-1	2016	Glutathione S-transferase P (GSTP), and possibly other members of the subfamily of cytosolic GSTs, are increasingly proposed to have roles far beyond the classical GSH-dependent enzymatic detoxification of electrophilic metabolites and xenobiotics.	Glutathione	164-167	glutathione S-transferase pi 1	Homo sapiens	93-97
27038437-4	2016	In combination with NMR data, the nanopore measurements showed that the addition of Nutlin-3 rescued MDM2 translocation, indicating that Nutlin-3 disrupted the MDM2/GST-p53TAD complex, thereby releasing MDM2.	nutlin 3	84-92	glutathione S-transferase pi 1	Homo sapiens	165-170
27038437-4	2016	In combination with NMR data, the nanopore measurements showed that the addition of Nutlin-3 rescued MDM2 translocation, indicating that Nutlin-3 disrupted the MDM2/GST-p53TAD complex, thereby releasing MDM2.	nutlin 3	137-145	glutathione S-transferase pi 1	Homo sapiens	165-170
27086966-3	2016	Here, we show for the first time that upon MPTP-induced oxidative stress, GSTP potentiates S-glutathionylation of Kelch-like ECH-associated protein 1 (Keap1), an endogenous repressor of Nrf2, in vivo.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	43-47	glutathione S-transferase pi 1	Homo sapiens	74-78
26967570-0	2016	Val/Val glutathione-S-transferase P1 polymorphism predicts nonresponders in psoriasis patients treated with fumaric acid esters.	Fumarates	108-127	glutathione S-transferase pi 1	Homo sapiens	8-36
26967570-3	2016	We aimed to determine whether glutathione-S-transferase (GST) M1 and GSTP1 polymorphisms are associated with treatment outcome in psoriasis patients treated with FAE.	Fumarates	162-165	glutathione S-transferase pi 1	Homo sapiens	69-74
26970057-8	2016	This study suggested that MRP1 G1666A alone and, also, combined with GSTP1 Ile105Val were associated with inter-individual variations in urinary arsenic levels, but not with blood arsenic levels.	Arsenic	145-152	glutathione S-transferase pi 1	Homo sapiens	69-74
25008867-6	2016	CONCLUSION: Among Japanese women who received epirubicin and cyclophosphamide as perioperative chemotherapy for early breast cancer, those with the A/A genotype of the GSTP1 polymorphism (rs1695) were more likely to have FN.	Epirubicin	46-56	glutathione S-transferase pi 1	Homo sapiens	168-173
25735248-11	2016	Such major effects were similarly seen for GSTP1 A114V (OR 1.14, 95% CI 1.01-1.29 for Val/Val + Ala/Val vs. Ala/Ala).	Valine	86-89	glutathione S-transferase pi 1	Homo sapiens	43-48
25735248-11	2016	Such major effects were similarly seen for GSTP1 A114V (OR 1.14, 95% CI 1.01-1.29 for Val/Val + Ala/Val vs. Ala/Ala).	Valine	90-93	glutathione S-transferase pi 1	Homo sapiens	43-48
25735248-11	2016	Such major effects were similarly seen for GSTP1 A114V (OR 1.14, 95% CI 1.01-1.29 for Val/Val + Ala/Val vs. Ala/Ala).	Alanine	96-99	glutathione S-transferase pi 1	Homo sapiens	43-48
25735248-11	2016	Such major effects were similarly seen for GSTP1 A114V (OR 1.14, 95% CI 1.01-1.29 for Val/Val + Ala/Val vs. Ala/Ala).	Valine	90-93	glutathione S-transferase pi 1	Homo sapiens	43-48
25735248-11	2016	Such major effects were similarly seen for GSTP1 A114V (OR 1.14, 95% CI 1.01-1.29 for Val/Val + Ala/Val vs. Ala/Ala).	Alanine	108-111	glutathione S-transferase pi 1	Homo sapiens	43-48
25735248-11	2016	Such major effects were similarly seen for GSTP1 A114V (OR 1.14, 95% CI 1.01-1.29 for Val/Val + Ala/Val vs. Ala/Ala).	Alanine	108-111	glutathione S-transferase pi 1	Homo sapiens	43-48
25008867-6	2016	CONCLUSION: Among Japanese women who received epirubicin and cyclophosphamide as perioperative chemotherapy for early breast cancer, those with the A/A genotype of the GSTP1 polymorphism (rs1695) were more likely to have FN.	Cyclophosphamide	61-77	glutathione S-transferase pi 1	Homo sapiens	168-173
25633095-0	2016	GSTM1 Null Genotype and GSTP1 Ile105Val Polymorphism Are Associated with Alzheimer"s Disease: a Meta-Analysis.	ile105val	30-39	glutathione S-transferase pi 1	Homo sapiens	24-29
25633095-10	2016	GSTM1 null genotype and GSTP1 Ile105Val polymorphism are associated with increased risk of Alzheimer"s disease.	ile105val	30-39	glutathione S-transferase pi 1	Homo sapiens	24-29
26927197-4	2016	In this study, we assess the binding interactions of four flavonoids (kaempferol, luteolin, quercetin, and resveratrol) with human serum albumin (HSA), the most abundant protein in the blood, and with glutathione S-transferase pi isoform-1 (GSTP1), an enzyme with well-characterized hydrophobic binding sites that plays an important role in detoxification of xenobiotics with reduced glutathione, using a novel Taylor dispersion surface plasmon resonance (SPR) technique.	Flavonoids	58-68	glutathione S-transferase pi 1	Homo sapiens	201-239
26927197-4	2016	In this study, we assess the binding interactions of four flavonoids (kaempferol, luteolin, quercetin, and resveratrol) with human serum albumin (HSA), the most abundant protein in the blood, and with glutathione S-transferase pi isoform-1 (GSTP1), an enzyme with well-characterized hydrophobic binding sites that plays an important role in detoxification of xenobiotics with reduced glutathione, using a novel Taylor dispersion surface plasmon resonance (SPR) technique.	Flavonoids	58-68	glutathione S-transferase pi 1	Homo sapiens	241-246
26927197-4	2016	In this study, we assess the binding interactions of four flavonoids (kaempferol, luteolin, quercetin, and resveratrol) with human serum albumin (HSA), the most abundant protein in the blood, and with glutathione S-transferase pi isoform-1 (GSTP1), an enzyme with well-characterized hydrophobic binding sites that plays an important role in detoxification of xenobiotics with reduced glutathione, using a novel Taylor dispersion surface plasmon resonance (SPR) technique.	Resveratrol	107-118	glutathione S-transferase pi 1	Homo sapiens	201-239
26927197-4	2016	In this study, we assess the binding interactions of four flavonoids (kaempferol, luteolin, quercetin, and resveratrol) with human serum albumin (HSA), the most abundant protein in the blood, and with glutathione S-transferase pi isoform-1 (GSTP1), an enzyme with well-characterized hydrophobic binding sites that plays an important role in detoxification of xenobiotics with reduced glutathione, using a novel Taylor dispersion surface plasmon resonance (SPR) technique.	kaempferol	70-80	glutathione S-transferase pi 1	Homo sapiens	201-239
26927197-4	2016	In this study, we assess the binding interactions of four flavonoids (kaempferol, luteolin, quercetin, and resveratrol) with human serum albumin (HSA), the most abundant protein in the blood, and with glutathione S-transferase pi isoform-1 (GSTP1), an enzyme with well-characterized hydrophobic binding sites that plays an important role in detoxification of xenobiotics with reduced glutathione, using a novel Taylor dispersion surface plasmon resonance (SPR) technique.	Resveratrol	107-118	glutathione S-transferase pi 1	Homo sapiens	241-246
26927197-7	2016	GSTP1 displayed lower affinities in the micromolar range towards all of the flavonoids tested.	Flavonoids	76-86	glutathione S-transferase pi 1	Homo sapiens	0-5
26927197-8	2016	The interactions of flavonoids with HSA and GSTP1 were studied successfully using this novel SPR assay method.	Flavonoids	20-30	glutathione S-transferase pi 1	Homo sapiens	44-49
26927197-4	2016	In this study, we assess the binding interactions of four flavonoids (kaempferol, luteolin, quercetin, and resveratrol) with human serum albumin (HSA), the most abundant protein in the blood, and with glutathione S-transferase pi isoform-1 (GSTP1), an enzyme with well-characterized hydrophobic binding sites that plays an important role in detoxification of xenobiotics with reduced glutathione, using a novel Taylor dispersion surface plasmon resonance (SPR) technique.	Quercetin	92-101	glutathione S-transferase pi 1	Homo sapiens	201-239
26447830-10	2016	Restoration of GSTP1 expression resulted in changes in modified glutathione levels that correlated with GSTP1 protein levels in response to protracted LDR-induced oxidative stress.	Glutathione	64-75	glutathione S-transferase pi 1	Homo sapiens	15-20
26396136-0	2015	Transformation of alkylating regimen of thiotepa into tepa determines the disease progression through GSTP1 gene polymorphism for metastatic breast cancer patients receiving thiotepa containing salvage chemotherapy.	Thiotepa	40-48	glutathione S-transferase pi 1	Homo sapiens	102-107
26429914-3	2015	In tumor cells, which frequently are characterized by constitutively high GSTP1 expression, GSTP1 undergoes phosphorylation by epidermal growth factor receptor (EGFR) at tyrosine residues 3, 7, and 198.	Tyrosine	170-178	glutathione S-transferase pi 1	Homo sapiens	74-79
26429914-3	2015	In tumor cells, which frequently are characterized by constitutively high GSTP1 expression, GSTP1 undergoes phosphorylation by epidermal growth factor receptor (EGFR) at tyrosine residues 3, 7, and 198.	Tyrosine	170-178	glutathione S-transferase pi 1	Homo sapiens	92-97
26429914-4	2015	Here we report on the effect of this EGFR-dependent GSTP1 tyrosine phosphorylation on the interaction of GSTP1 with JNK, on the regulation of JNK downstream signaling by GSTP1, and on tumor cell survival.	Tyrosine	58-66	glutathione S-transferase pi 1	Homo sapiens	52-57
26429914-4	2015	Here we report on the effect of this EGFR-dependent GSTP1 tyrosine phosphorylation on the interaction of GSTP1 with JNK, on the regulation of JNK downstream signaling by GSTP1, and on tumor cell survival.	Tyrosine	58-66	glutathione S-transferase pi 1	Homo sapiens	105-110
26429914-4	2015	Here we report on the effect of this EGFR-dependent GSTP1 tyrosine phosphorylation on the interaction of GSTP1 with JNK, on the regulation of JNK downstream signaling by GSTP1, and on tumor cell survival.	Tyrosine	58-66	glutathione S-transferase pi 1	Homo sapiens	105-110
26429914-5	2015	Using in vitro and in vivo growing human brain tumors, we show that tyrosine phosphorylation shifts the GSTP1 dimer-monomer equilibrium to the monomeric state and facilitates the formation of the GSTP1-JNK complex, in which JNK is functionally inhibited.	Tyrosine	68-76	glutathione S-transferase pi 1	Homo sapiens	104-109
26429914-5	2015	Using in vitro and in vivo growing human brain tumors, we show that tyrosine phosphorylation shifts the GSTP1 dimer-monomer equilibrium to the monomeric state and facilitates the formation of the GSTP1-JNK complex, in which JNK is functionally inhibited.	Tyrosine	68-76	glutathione S-transferase pi 1	Homo sapiens	196-201
26429914-6	2015	Targeted mutagenesis and functional analysis demonstrated that the increased GSTP1 binding to JNK results from phosphorylation of the GSTP1 C-terminal Tyr-198 by EGFR and is associated with a >2.5-fold decrease in JNK downstream signaling and a significant suppression of both spontaneous and drug-induced apoptosis in the tumor cells.	Tyrosine	151-154	glutathione S-transferase pi 1	Homo sapiens	77-82
26429914-6	2015	Targeted mutagenesis and functional analysis demonstrated that the increased GSTP1 binding to JNK results from phosphorylation of the GSTP1 C-terminal Tyr-198 by EGFR and is associated with a >2.5-fold decrease in JNK downstream signaling and a significant suppression of both spontaneous and drug-induced apoptosis in the tumor cells.	Tyrosine	151-154	glutathione S-transferase pi 1	Homo sapiens	134-139
26554337-4	2015	Therefore, we incubated GSTA1, GSTT1, GSTM1, and GSTP1 with glutathione and BO and quantified the formation of S-phenylglutathione.	Glutathione	60-71	glutathione S-transferase pi 1	Homo sapiens	49-54
26554337-4	2015	Therefore, we incubated GSTA1, GSTT1, GSTM1, and GSTP1 with glutathione and BO and quantified the formation of S-phenylglutathione.	benzene oxide	76-78	glutathione S-transferase pi 1	Homo sapiens	49-54
27073511-1	2016	The effects of platinum-based drugs are controlled by genes that are involved in DNA detoxification, including glutathione S-transferase (GST)P1 and GSTM1, which have been associated with increased benefits in the chemotherapeutic treatment of patients with ovarian cancer.	Platinum	15-23	glutathione S-transferase pi 1	Homo sapiens	138-144
27073515-0	2016	Demethylation effects of elemene on the GSTP1 gene in HCC cell line QGY7703.	elemene	25-32	glutathione S-transferase pi 1	Homo sapiens	40-45
27073515-1	2016	The present study aimed to investigate elemene"s effects on cell proliferation, apoptosis, and the cell cycle in the hepatocellular carcinoma (HCC) cell line, QYG7703, and to investigate GSTP1 gene methylation change in QGY7703 cells after being treated with elemene to explore whether elemene reversed the abnormal GSTP1 gene methylation.	elemene	39-46	glutathione S-transferase pi 1	Homo sapiens	316-321
27073515-7	2016	In the present study, elemene induced cell apoptosis, inhibited the cell cycle, and reversed GSTP1 gene methylation in QGY7703 cells.	elemene	22-29	glutathione S-transferase pi 1	Homo sapiens	93-98
26823947-5	2016	Our data revealed a statistically significant difference regarding the frequencies of GPX1 Pro198Leu and GSTP1 Ile105Val variant genotypes between AML patients and controls (p < 0.001).	ile105val	111-120	glutathione S-transferase pi 1	Homo sapiens	105-110
26725685-6	2016	GSTP1 methylation was significantly higher in patients with CHB than HCs (P = 0.047).	Homocysteine	69-72	glutathione S-transferase pi 1	Homo sapiens	0-5
26725685-10	2016	In patients with CHB, the degree of GSTP1 promoter methylation was significantly correlated with DNMT1 mRNA, DNMT3a mRNA, TNF-alpha, MDA, HBeAg, ALT, AST and TBIL.	tbil	158-162	glutathione S-transferase pi 1	Homo sapiens	36-41
25891019-1	2015	The selectivity of certain benzophenones and their carbonyl N-analogues was investigated towards the human GSTP1-1 allozymes A, B and C involved in MDR.	Benzophenones	27-40	glutathione S-transferase pi 1	Homo sapiens	107-114
25891019-1	2015	The selectivity of certain benzophenones and their carbonyl N-analogues was investigated towards the human GSTP1-1 allozymes A, B and C involved in MDR.	Nitrogen	60-61	glutathione S-transferase pi 1	Homo sapiens	107-114
26823821-1	2015	We conducted a study to investigate the association between the clinical outcome and GSTP1 Ile105Val and XRCC1 Arg194Trp, Arg280His and Arg399Gln gene polymorphisms in advanced NSCLC patients with cisplatin-based chemotherapy.	ile105val	91-100	glutathione S-transferase pi 1	Homo sapiens	85-90
26823821-1	2015	We conducted a study to investigate the association between the clinical outcome and GSTP1 Ile105Val and XRCC1 Arg194Trp, Arg280His and Arg399Gln gene polymorphisms in advanced NSCLC patients with cisplatin-based chemotherapy.	Cisplatin	197-206	glutathione S-transferase pi 1	Homo sapiens	85-90
26396136-0	2015	Transformation of alkylating regimen of thiotepa into tepa determines the disease progression through GSTP1 gene polymorphism for metastatic breast cancer patients receiving thiotepa containing salvage chemotherapy.	Triethylenephosphoramide	44-48	glutathione S-transferase pi 1	Homo sapiens	102-107
26396136-0	2015	Transformation of alkylating regimen of thiotepa into tepa determines the disease progression through GSTP1 gene polymorphism for metastatic breast cancer patients receiving thiotepa containing salvage chemotherapy.	Thiotepa	174-182	glutathione S-transferase pi 1	Homo sapiens	102-107
26396136-11	2015	CONCLUSIONS: These results suggest that the GSTP1 polymorphism is a novel prognostic marker for clinical response to thiotepa-containing chemotherapy regimens.	Thiotepa	117-125	glutathione S-transferase pi 1	Homo sapiens	44-49
26490046-9	2015	Children with AA at nucleotide 1695 in GSTP1 who had been exposed to ETS and a low vitamin A intake have an increased risk of asthma diagnosis (aOR, 4.44; 95 % CI,1.58-12.52) compared with children who had not been exposed to the two risk factors.	Vitamin A	83-92	glutathione S-transferase pi 1	Homo sapiens	39-44
26309447-2	2015	Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC >= 12microg/L had about 4 times higher odds of ASD than those with BMC < 12microg/L, (P=0.03) under a co-dominant genetic model.	bmc	105-108	glutathione S-transferase pi 1	Homo sapiens	76-84
26770457-7	2015	Our meta-analysis showed that GSTP1 Ile105Val polymorphisms might not be significantly associated with coronary heart disease risk.	ile105val	36-45	glutathione S-transferase pi 1	Homo sapiens	30-35
26432087-9	2015	GST-P1 Ile105/Ile105 genotype appeared to be a promising marker indicating predisposition to AZA-related ADRs.	Azathioprine	93-96	glutathione S-transferase pi 1	Homo sapiens	0-6
26219504-12	2015	Immunohistochemical staining showed an increase in proliferating cell nuclear antigen (PCNA)-positive cells, along with enhanced AhR protein expression in hepatocytes within GST-P-positive foci of (DEN HCB) group, when compared to DEN.	den hcb	198-205	glutathione S-transferase pi 1	Homo sapiens	174-179
26219504-12	2015	Immunohistochemical staining showed an increase in proliferating cell nuclear antigen (PCNA)-positive cells, along with enhanced AhR protein expression in hepatocytes within GST-P-positive foci of (DEN HCB) group, when compared to DEN.	Diethylnitrosamine	198-201	glutathione S-transferase pi 1	Homo sapiens	174-179
26309447-2	2015	Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC >= 12microg/L had about 4 times higher odds of ASD than those with BMC < 12microg/L, (P=0.03) under a co-dominant genetic model.	bmc	105-108	glutathione S-transferase pi 1	Homo sapiens	86-91
26309447-2	2015	Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC >= 12microg/L had about 4 times higher odds of ASD than those with BMC < 12microg/L, (P=0.03) under a co-dominant genetic model.	bmc	179-182	glutathione S-transferase pi 1	Homo sapiens	76-84
26309447-2	2015	Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC >= 12microg/L had about 4 times higher odds of ASD than those with BMC < 12microg/L, (P=0.03) under a co-dominant genetic model.	bmc	179-182	glutathione S-transferase pi 1	Homo sapiens	86-91
26205366-3	2015	In this study, we synthesized and investigated the inhibitory effects of differently substituted 3-arylcoumarin derivatives on human placental GST, identified as GSTP1-1, using 1-chloro-2,4-dinitrobenzene as a substrate.	3-arylcoumarin	97-111	glutathione S-transferase pi 1	Homo sapiens	162-169
26354850-5	2015	GSTP1 rs1695 and GSTO1 rs4925 were also associated with RFS in the epirubicin group.	Epirubicin	67-77	glutathione S-transferase pi 1	Homo sapiens	0-5
26354850-7	2015	Patients with the GSTP1 AA and GSTO1 CC genotypes had a reduced risk of recurrence after the instillation of epirubicin.	Epirubicin	109-119	glutathione S-transferase pi 1	Homo sapiens	18-23
26354850-9	2015	Our results suggest that GSTP1 and GSTO1 polymorphisms are associated with epirubicin treatment outcomes as well as with epirubicin-related toxicity.	Epirubicin	75-85	glutathione S-transferase pi 1	Homo sapiens	25-30
26354850-9	2015	Our results suggest that GSTP1 and GSTO1 polymorphisms are associated with epirubicin treatment outcomes as well as with epirubicin-related toxicity.	Epirubicin	121-131	glutathione S-transferase pi 1	Homo sapiens	25-30
26205366-3	2015	In this study, we synthesized and investigated the inhibitory effects of differently substituted 3-arylcoumarin derivatives on human placental GST, identified as GSTP1-1, using 1-chloro-2,4-dinitrobenzene as a substrate.	Dinitrochlorobenzene	177-204	glutathione S-transferase pi 1	Homo sapiens	162-169
26345972-5	2015	The results of our study suggest that the GSTP1 rs1695 and XRCC1 rs25487 polymorphisms might affect the clinical outcome of patients with advanced NSCLC receiving cisplatin-based chemotherapy.	Cisplatin	163-172	glutathione S-transferase pi 1	Homo sapiens	42-47
26033426-0	2015	Clinical outcome of cisplatin-based chemotherapy is associated with the polymorphisms of GSTP1 and XRCC1 in advanced non-small cell lung cancer patients.	Cisplatin	20-29	glutathione S-transferase pi 1	Homo sapiens	89-94
26033426-1	2015	INTRODUCTION: This study is to evaluate the association of polymorphisms of glutathione S-transferase P1 (GSTP1), copper-transporting P-type adenosine triphosphatase A (ATP7A) and X-ray repair cross-complementing group 1 (XRCC1) with the efficacy and toxicity of cisplatin-based treatment in advanced non-small cell lung cancer (NSCLC) patients.	Cisplatin	263-272	glutathione S-transferase pi 1	Homo sapiens	76-104
26033426-1	2015	INTRODUCTION: This study is to evaluate the association of polymorphisms of glutathione S-transferase P1 (GSTP1), copper-transporting P-type adenosine triphosphatase A (ATP7A) and X-ray repair cross-complementing group 1 (XRCC1) with the efficacy and toxicity of cisplatin-based treatment in advanced non-small cell lung cancer (NSCLC) patients.	Cisplatin	263-272	glutathione S-transferase pi 1	Homo sapiens	106-111
26033426-9	2015	CONCLUSIONS: Advanced NSCLC patients with AA genotype of GSTP1 would obtain better curative effect followed with more risk of anemia when treated by cisplatin-based chemotherapy.	Cisplatin	149-158	glutathione S-transferase pi 1	Homo sapiens	57-62
26622693-4	2015	A HeLa cell line that was stably expressing high levels of GSTP1 was obtained through stable transfection of the constructed plasmids using lipofectamine and screening for G418 resistance, as demonstrated by reverse transcription-PCR.	Lipofectamine	140-153	glutathione S-transferase pi 1	Homo sapiens	59-64
26622693-4	2015	A HeLa cell line that was stably expressing high levels of GSTP1 was obtained through stable transfection of the constructed plasmids using lipofectamine and screening for G418 resistance, as demonstrated by reverse transcription-PCR.	antibiotic G 418	172-176	glutathione S-transferase pi 1	Homo sapiens	59-64
26295386-0	2015	Genetic Polymorphisms of Glutathione-Related Enzymes (GSTM1, GSTT1, and GSTP1) and Schizophrenia Risk: A Meta-Analysis.	Glutathione	25-36	glutathione S-transferase pi 1	Homo sapiens	72-77
26043946-3	2015	Here we show that a simple replacement of cyano for nitro at the 4 position to give compound 4b ("p-cyano-PABA/NO") has the dual effect of slowing the undesired side reactions while enhancing the proportion of NO release and arylating activity on catalysis by GSTP1.	Cyanides	42-47	glutathione S-transferase pi 1	Homo sapiens	260-265
26044055-8	2015	Furthermore, subgroup analysis by histological types showed that GSTP1 Ile105Val polymorphism was associated with risks of malignant melanoma under the dominant model (Val/Val + Val/Ile vs. Ile/Ile: OR 1.230, 95 % CI 1.017-1.488, P = 0.033).	ile105val	71-80	glutathione S-transferase pi 1	Homo sapiens	65-70
26044055-8	2015	Furthermore, subgroup analysis by histological types showed that GSTP1 Ile105Val polymorphism was associated with risks of malignant melanoma under the dominant model (Val/Val + Val/Ile vs. Ile/Ile: OR 1.230, 95 % CI 1.017-1.488, P = 0.033).	Valine	77-80	glutathione S-transferase pi 1	Homo sapiens	65-70
26711214-0	2015	[Relationship of GSTP1 lower expression and multidrug resistance reversing of curcumin on human colon carcinoma cells].	Curcumin	78-86	glutathione S-transferase pi 1	Homo sapiens	17-22
26711214-9	2015	RT-PCR and Western blotting results showed that the expressions of GSTP1 mRNA (0.49+-0.09) and protein (0.29+-0.07) in curcumin-treated group were significantly lower than in control group (GSTP1 mRNA 1.19+-0.21 and protein 0.70+-0.13, both P<0.05), indicating that curcumin down regulated these expressions.	Curcumin	119-127	glutathione S-transferase pi 1	Homo sapiens	67-72
26711214-9	2015	RT-PCR and Western blotting results showed that the expressions of GSTP1 mRNA (0.49+-0.09) and protein (0.29+-0.07) in curcumin-treated group were significantly lower than in control group (GSTP1 mRNA 1.19+-0.21 and protein 0.70+-0.13, both P<0.05), indicating that curcumin down regulated these expressions.	Curcumin	119-127	glutathione S-transferase pi 1	Homo sapiens	190-195
26711214-9	2015	RT-PCR and Western blotting results showed that the expressions of GSTP1 mRNA (0.49+-0.09) and protein (0.29+-0.07) in curcumin-treated group were significantly lower than in control group (GSTP1 mRNA 1.19+-0.21 and protein 0.70+-0.13, both P<0.05), indicating that curcumin down regulated these expressions.	Curcumin	269-277	glutathione S-transferase pi 1	Homo sapiens	67-72
26711214-10	2015	CONCLUSIONS: The suppression of GSTP1 by curcumin could enhance the vincristine chemosensitivity in HCT-8/VCR.	Curcumin	41-49	glutathione S-transferase pi 1	Homo sapiens	32-37
26711214-10	2015	CONCLUSIONS: The suppression of GSTP1 by curcumin could enhance the vincristine chemosensitivity in HCT-8/VCR.	Vincristine	68-79	glutathione S-transferase pi 1	Homo sapiens	32-37
26711214-11	2015	GSTP1 overexpression may be involved in the vincristine -resistance of human colon carcinoma cells.	Vincristine	44-55	glutathione S-transferase pi 1	Homo sapiens	0-5
26043946-3	2015	Here we show that a simple replacement of cyano for nitro at the 4 position to give compound 4b ("p-cyano-PABA/NO") has the dual effect of slowing the undesired side reactions while enhancing the proportion of NO release and arylating activity on catalysis by GSTP1.	nitro	52-57	glutathione S-transferase pi 1	Homo sapiens	260-265
26043946-3	2015	Here we show that a simple replacement of cyano for nitro at the 4 position to give compound 4b ("p-cyano-PABA/NO") has the dual effect of slowing the undesired side reactions while enhancing the proportion of NO release and arylating activity on catalysis by GSTP1.	p-cyano-paba	98-110	glutathione S-transferase pi 1	Homo sapiens	260-265
25577235-7	2015	One methylated MSP product corresponding to the GSTP1, lack of methylated cytosine, was clearly detected on gel electrophoresis but barely visible on MSP-DB.	Cytosine	74-82	glutathione S-transferase pi 1	Homo sapiens	48-53
26040771-8	2015	GSTP1 methylation level was significantly correlated with total bilirubin (r = 0.29, P < 0.01), prothrombin time activity (r = -0.24, P = 0.01) and model for end-stage liver disease (MELD) score (r = 0.26, P = 0.01).	Bilirubin	64-73	glutathione S-transferase pi 1	Homo sapiens	0-5
26258094-2	2015	Detoxification of ROS is largely performed by Glutathione S-transferases (GSTs), therefore polymorphisms of GSTM1, GSTT1 and GSTP1 genes which decrease enzymes activity could affect SLE susceptibility.	Reactive Oxygen Species	18-21	glutathione S-transferase pi 1	Homo sapiens	125-130
26046522-0	2015	Modifying Role of GSTP1 Polymorphism on the Association between Tea Fluoride Exposure and the Brick-Tea Type Fluorosis.	tea fluoride	64-76	glutathione S-transferase pi 1	Homo sapiens	18-23
25677905-0	2015	Effect of GSTP1 and ABCC4 gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-5-fluorouracil-based chemotherapy in Bangladeshi breast cancer patients.	Cyclophosphamide	73-89	glutathione S-transferase pi 1	Homo sapiens	10-15
25677905-0	2015	Effect of GSTP1 and ABCC4 gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-5-fluorouracil-based chemotherapy in Bangladeshi breast cancer patients.	epirubicin-5-fluorouracil	90-115	glutathione S-transferase pi 1	Homo sapiens	10-15
25677905-1	2015	The most important cytotoxic drug namely, cyclophosphamide used in breast cancer along with epirubicin and 5-fluorouracil, is transported by ABCC transporters and detoxified by glutathione S-transferases (GSTs).	Cyclophosphamide	42-58	glutathione S-transferase pi 1	Homo sapiens	205-209
25677905-1	2015	The most important cytotoxic drug namely, cyclophosphamide used in breast cancer along with epirubicin and 5-fluorouracil, is transported by ABCC transporters and detoxified by glutathione S-transferases (GSTs).	Epirubicin	92-102	glutathione S-transferase pi 1	Homo sapiens	205-209
25677905-1	2015	The most important cytotoxic drug namely, cyclophosphamide used in breast cancer along with epirubicin and 5-fluorouracil, is transported by ABCC transporters and detoxified by glutathione S-transferases (GSTs).	Fluorouracil	107-121	glutathione S-transferase pi 1	Homo sapiens	205-209
25800511-4	2015	Furthermore, phenethyl isothiocyanate and indole-3-carbinol increased the transcript and protein levels of GSTA, GSTP, GSTM, GSTT, and NQO1.	phenethyl isothiocyanate	13-37	glutathione S-transferase pi 1	Homo sapiens	113-117
25868843-4	2015	Treatment with CY (100-300 mg/kg) increased plasma levels of creatine kinase-MB isoform (CK   MB) and heart-to-body weight ratio to a significantly greater extent in GSTP-null than WT mice.	Cyclophosphamide	15-17	glutathione S-transferase pi 1	Homo sapiens	166-170
25868843-5	2015	In addition to modest yet significant echocardiographic changes following acute CY-treatment, GSTP insufficiency was associated with greater phosphorylation of c-Jun and p38 as well as greater accumulation of albumin and protein-acrolein adducts in the heart.	Cyclophosphamide	80-82	glutathione S-transferase pi 1	Homo sapiens	94-98
25868843-8	2015	Acrolein induced similar hypotension in GSTP-null and WT mice.	Acrolein	0-8	glutathione S-transferase pi 1	Homo sapiens	40-44
25868843-9	2015	GSTP-null mice also were more susceptible than WT mice to mortality associated with high-dose acrolein (10-20 mg/kg).	Acrolein	94-102	glutathione S-transferase pi 1	Homo sapiens	0-4
25868843-10	2015	Collectively, these results suggest that CY cardiotoxicity is regulated, in part, by GSTP, which prevents CY toxicity by detoxifying acrolein.	Cyclophosphamide	41-43	glutathione S-transferase pi 1	Homo sapiens	85-89
25868843-10	2015	Collectively, these results suggest that CY cardiotoxicity is regulated, in part, by GSTP, which prevents CY toxicity by detoxifying acrolein.	Cyclophosphamide	106-108	glutathione S-transferase pi 1	Homo sapiens	85-89
25868843-10	2015	Collectively, these results suggest that CY cardiotoxicity is regulated, in part, by GSTP, which prevents CY toxicity by detoxifying acrolein.	Acrolein	133-141	glutathione S-transferase pi 1	Homo sapiens	85-89
25868843-11	2015	Thus, humans with low cardiac GSTP levels or polymorphic forms of GSTP with low acrolein-metabolizing capacity may be more sensitive to CY toxicity.	Cyclophosphamide	136-138	glutathione S-transferase pi 1	Homo sapiens	30-34
25868843-11	2015	Thus, humans with low cardiac GSTP levels or polymorphic forms of GSTP with low acrolein-metabolizing capacity may be more sensitive to CY toxicity.	Cyclophosphamide	136-138	glutathione S-transferase pi 1	Homo sapiens	66-70
25800511-4	2015	Furthermore, phenethyl isothiocyanate and indole-3-carbinol increased the transcript and protein levels of GSTA, GSTP, GSTM, GSTT, and NQO1.	indole-3-carbinol	42-59	glutathione S-transferase pi 1	Homo sapiens	113-117
26284209-4	2015	RESULTS: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively).	Isoleucine	61-71	glutathione S-transferase pi 1	Homo sapiens	50-55
26023743-5	2015	To its underlying mechanistic on ROS system, 4-HNE elevated the ROS generation enzyme NADPH oxidase 4 (NOX4) and induced the activation of NF-E2-related factor-2 (NRF2) and its downstream effectors: NAD(P)H dehydrogenase (quinone 1) (NQO1) and glutathione S-transferase P (GSTP).	ros	33-36	glutathione S-transferase pi 1	Homo sapiens	244-271
26023743-5	2015	To its underlying mechanistic on ROS system, 4-HNE elevated the ROS generation enzyme NADPH oxidase 4 (NOX4) and induced the activation of NF-E2-related factor-2 (NRF2) and its downstream effectors: NAD(P)H dehydrogenase (quinone 1) (NQO1) and glutathione S-transferase P (GSTP).	ros	33-36	glutathione S-transferase pi 1	Homo sapiens	273-277
26284209-4	2015	RESULTS: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively).	Isoleucine	61-71	glutathione S-transferase pi 1	Homo sapiens	91-96
26284209-4	2015	RESULTS: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively).	Valine	72-78	glutathione S-transferase pi 1	Homo sapiens	50-55
26284209-4	2015	RESULTS: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively).	Valine	102-108	glutathione S-transferase pi 1	Homo sapiens	91-96
26284209-4	2015	RESULTS: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively).	Valine	102-108	glutathione S-transferase pi 1	Homo sapiens	91-96
25462236-1	2015	The 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX, 1), a "suicide inhibitor" of the glutathione-S-transferase GSTP1-1, showed pro-apoptotic properties in tumor cells, but in vivo studies were limited by poor bioavailability and high affinity towards GSTM2-2, expressed in many non-cancerous tissues.	6-((7-nitrobenzo(c)(1,2,5)oxadiazol-4-yl)thio)hexan-1-ol	4-60	glutathione S-transferase pi 1	Homo sapiens	129-136
25677447-9	2015	CONCLUSIONS: Germline polymorphisms of DPYD, TYMS and GSTP1 have a significant effect on toxicity and clinical outcome in patients receiving capecitabine-based chemotherapy for advanced colorectal or gastroesophageal cancer.	Capecitabine	141-153	glutathione S-transferase pi 1	Homo sapiens	54-59
25694385-5	2015	A new series of 1,2,4-trioxane GSTP1 inhibitors were designed via a type II photooxygenation route of allylic alcohols followed by acid-catalyzed peroxyacetalization with aldehydes.	1,2,4-trioxane	16-30	glutathione S-transferase pi 1	Homo sapiens	31-36
25694385-5	2015	A new series of 1,2,4-trioxane GSTP1 inhibitors were designed via a type II photooxygenation route of allylic alcohols followed by acid-catalyzed peroxyacetalization with aldehydes.	allyl alcohol	102-118	glutathione S-transferase pi 1	Homo sapiens	31-36
25694385-5	2015	A new series of 1,2,4-trioxane GSTP1 inhibitors were designed via a type II photooxygenation route of allylic alcohols followed by acid-catalyzed peroxyacetalization with aldehydes.	Aldehydes	171-180	glutathione S-transferase pi 1	Homo sapiens	31-36
25524402-6	2015	The multivariate linear regression adjusting for selenium status showed that plasma Se level was significantly inversely associated only with expression of GSTP1 (beta-coef.=-0.270, p=0.009), PRDXR1 (beta-coef.=-0.245, p=0.017) and SOD2 with an inverse trend toward significance (beta-coef.=-0.186, p=0.074), but without an effect of NRF2 gene variants.	Selenium	84-86	glutathione S-transferase pi 1	Homo sapiens	156-161
25462116-6	2015	A highly active P450 BM3 mutant (CYP102A1M11H) was subsequently used for bioactivation of acetaminophen, clozapine, diclofenac (DF) and mefenamic acid (MFA), but hGST P1-1 adducts were only observed for the latter two drugs.	Acetaminophen	90-103	glutathione S-transferase pi 1	Homo sapiens	162-171
25462116-6	2015	A highly active P450 BM3 mutant (CYP102A1M11H) was subsequently used for bioactivation of acetaminophen, clozapine, diclofenac (DF) and mefenamic acid (MFA), but hGST P1-1 adducts were only observed for the latter two drugs.	Clozapine	105-114	glutathione S-transferase pi 1	Homo sapiens	162-171
25462116-6	2015	A highly active P450 BM3 mutant (CYP102A1M11H) was subsequently used for bioactivation of acetaminophen, clozapine, diclofenac (DF) and mefenamic acid (MFA), but hGST P1-1 adducts were only observed for the latter two drugs.	Diclofenac	116-126	glutathione S-transferase pi 1	Homo sapiens	162-171
25784989-4	2015	Herein, using BSP to assess the 5 mC level in promoters of ten specific marker gene in PCa, our results present that Cdh1, Gstp1, Pten, Apc, Runx3 and Mgmt are observed to be hypermethylated in promoters and lower expression while Cyr61, Sema3c and Ptgs2 are reversed patterns compared to the normal prostate tissues.	Methylcholanthrene	34-36	glutathione S-transferase pi 1	Homo sapiens	123-128
25785008-9	2015	CONCLUSIONS: These statistical data demonstrate that Ile105Val polymorphism of the GSTP1 gene may have genetic contribution to the development of skin cancer, MM in particular.	ile105val	53-62	glutathione S-transferase pi 1	Homo sapiens	83-88
25383449-6	2015	RESULTS: Patients with the genetic variants GSTP1 rs1138272 C/T or T/T (114Ala/114Val or 114Val/114Val) genotype had an adjusted odds ratio of 3.82; 95% confidence interval 1.34-11.09 of developing DIPN.	diisopropanolnitrosamine	198-202	glutathione S-transferase pi 1	Homo sapiens	44-49
25383449-10	2015	CONCLUSION: We found that GSTP1 Ala114Val polymorphism is associated with occurrence of DIPN.	diisopropanolnitrosamine	88-92	glutathione S-transferase pi 1	Homo sapiens	26-31
26097600-0	2015	Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcome of advanced non-small cell lung cancer patients with cisplatin-based chemotherapy.	Cisplatin	125-134	glutathione S-transferase pi 1	Homo sapiens	15-20
26097600-1	2015	We investigated the association between the clinical outcome and GSTP1 and XRCC1 gene polymorphisms in advanced NSCLC patients with cisplatin-based chemotherapy.	Cisplatin	132-141	glutathione S-transferase pi 1	Homo sapiens	65-70
26097600-8	2015	GSTP1 A313G and XRCC1 Arg399Gln gene polymorphisms might influence the response to cisplatin-based chemotherapy and affect the clinical outcome of advanced NSCLC.	Cisplatin	83-92	glutathione S-transferase pi 1	Homo sapiens	0-5
26005978-10	2015	-GSTP1 Ile/Ile 35.3% versus 60.9%; Ile/Val 45.9% versus 28.7%; Val/Val 18.8% versus 10.3%; p=0.0003.	Isoleucine	7-10	glutathione S-transferase pi 1	Homo sapiens	1-6
26005978-10	2015	-GSTP1 Ile/Ile 35.3% versus 60.9%; Ile/Val 45.9% versus 28.7%; Val/Val 18.8% versus 10.3%; p=0.0003.	Isoleucine	11-14	glutathione S-transferase pi 1	Homo sapiens	1-6
25452145-7	2015	In MCF-7 cells transfected with different allelic variants of GSTP, M-PhSeZnCl lowered the burst of cellular ROS induced by the exposure to extracellular H2O2, and the extent of this effect changed between the GSTP variants.	Reactive Oxygen Species	109-112	glutathione S-transferase pi 1	Homo sapiens	62-66
26028097-0	2015	Association of GSTP1 and RRM1 Polymorphisms with the Response and Toxicity of Gemcitabine-cisplatin Combination Chemotherapy in Chinese Patients with Non-small Cell Lung Cancer.	gemcitabine	78-89	glutathione S-transferase pi 1	Homo sapiens	15-20
26295823-0	2015	GSTP1 Polymorphisms and their Association with Glutathione Transferase and Peroxidase Activities in Patients with Motor Neuron Disease.	Glutathione	47-58	glutathione S-transferase pi 1	Homo sapiens	0-5
26295823-1	2015	Glutathione S-transferase pi (GSTP1) is a crucial enzyme in detoxification of electrophilic compounds and organic peroxides.	Peroxides	114-123	glutathione S-transferase pi 1	Homo sapiens	30-35
26028097-0	2015	Association of GSTP1 and RRM1 Polymorphisms with the Response and Toxicity of Gemcitabine-cisplatin Combination Chemotherapy in Chinese Patients with Non-small Cell Lung Cancer.	Cisplatin	90-99	glutathione S-transferase pi 1	Homo sapiens	15-20
26028097-1	2015	BACKGROUND: Previous studies showed that genetic polymorphisms of glutathione S-transferase P1 (GSTP1) were involved in glutathione metabolism and genetic polymorphisms of ribonucleotide reductase (RRM1) were correlated with DNA synthesis.	Glutathione	66-77	glutathione S-transferase pi 1	Homo sapiens	96-101
26028097-3	2015	MATERIALS AND METHODS: DNA sequencing was used to evaluate genetic polymorphisms of GSTP1 Ile105Val and RRM1 C37A-T524C in 47 NSCLC patients treated with gemcitabine-cisplatin regimens.	gemcitabine	154-165	glutathione S-transferase pi 1	Homo sapiens	84-89
25452145-7	2015	In MCF-7 cells transfected with different allelic variants of GSTP, M-PhSeZnCl lowered the burst of cellular ROS induced by the exposure to extracellular H2O2, and the extent of this effect changed between the GSTP variants.	Hydrogen Peroxide	154-158	glutathione S-transferase pi 1	Homo sapiens	62-66
25156511-3	2015	The 17 SNPs analyzed are involved in the ROS pathway (GSTP1, SOD2, NQO1, NOS3, XDH), DNA repair (XRCC1, XRCC3, XRCC6, ERCC2, LIG4, ATM) or TGFB signaling (SKIL, EP300, APC, AXIN1, TGFB1).	ros	41-44	glutathione S-transferase pi 1	Homo sapiens	54-59
25393952-5	2014	Although salivary alpha-defensins are also able to inhibit the enzyme causing a peculiar half-site inactivation, a number of approaches (mass spectrometry, site directed mutagenesis, chromatographic and spectrophotometric data) indicated that hypothiocyanite is the main salivary inhibitor of GSTP1-1.	hypothiocyanite ion	243-258	glutathione S-transferase pi 1	Homo sapiens	293-300
25188725-2	2014	There is an increased risk of CML in subjects with (i) deletions of genes encoding glutathione-S-transferase (GST)-theta1 (GSTT1) and -mu1, (GSTM1) and (ii) the GST-pi1 (GSTP1) single-nucleotide polymorphism (SNP) Ile105Val (GSTP1*B; rs1695); however, their effects on imatinib treatment outcome are not known.	Imatinib Mesylate	269-277	glutathione S-transferase pi 1	Homo sapiens	161-168
25372302-9	2014	The highest increase of total GSH conjugation was observed with hGSTP1-1, followed by hepatic hGSTs hGSTA2-2 and hGSTM1-1.	Glutathione	30-33	glutathione S-transferase pi 1	Homo sapiens	64-72
25393952-6	2014	Cys47 and Cys101, the most reactive sulfhydryls of GSTP1-1, are mainly involved in a redox interaction which leads to the formation of an intra-chain disulfide bridge.	Disulfides	150-159	glutathione S-transferase pi 1	Homo sapiens	51-58
25324722-6	2014	This study characterized 8-methoxypsoralen (8-MOP) as a human GST P1-1 (hGST P1-1) inhibitor.	Methoxsalen	25-42	glutathione S-transferase pi 1	Homo sapiens	62-70
26027129-6	2014	After the treatment with different concentrations of curcumin, Nuclear Nrf2 was decreased but Keapl was increased, and GSTP1 and NQO1 were decreased.	Curcumin	53-61	glutathione S-transferase pi 1	Homo sapiens	119-124
26027129-9	2014	The expression of typical phase I enzymes (GSTP1 and NQO1) mediated by Nrf2 are decreased by curcumin.	Curcumin	93-101	glutathione S-transferase pi 1	Homo sapiens	43-48
25324722-6	2014	This study characterized 8-methoxypsoralen (8-MOP) as a human GST P1-1 (hGST P1-1) inhibitor.	Methoxsalen	44-49	glutathione S-transferase pi 1	Homo sapiens	62-70
25324722-7	2014	To identify and characterize the potential inhibitory activity of 8-MOP, we studied the enzyme kinetics of the conjugation of 1-chloro-2,4-dinitrobenzene (CDNB) with GSH catalyzed by hGST P1-1.	Methoxsalen	66-71	glutathione S-transferase pi 1	Homo sapiens	183-192
25119182-15	2014	GSTP1*B/*B genotype was also associated with lower daunorubicin clearance compared to GSTP1*A/*A, p = 0.0347.	Daunorubicin	51-63	glutathione S-transferase pi 1	Homo sapiens	0-5
25119182-18	2014	We found suggestive associations between FMO3 and GSTP1 haplotypes with daunorubicin PK that could potentially affect efficacy and toxicity.	Daunorubicin	72-84	glutathione S-transferase pi 1	Homo sapiens	50-55
25324722-7	2014	To identify and characterize the potential inhibitory activity of 8-MOP, we studied the enzyme kinetics of the conjugation of 1-chloro-2,4-dinitrobenzene (CDNB) with GSH catalyzed by hGST P1-1.	Dinitrochlorobenzene	126-153	glutathione S-transferase pi 1	Homo sapiens	183-192
25356172-3	2014	METHODS: The lentiviral vector GSTP1-pWPXL was constructed and transfected into T24 cells in the presence of Lipofectamine 2000.	Lipofectamine	109-127	glutathione S-transferase pi 1	Homo sapiens	31-36
25324722-7	2014	To identify and characterize the potential inhibitory activity of 8-MOP, we studied the enzyme kinetics of the conjugation of 1-chloro-2,4-dinitrobenzene (CDNB) with GSH catalyzed by hGST P1-1.	Dinitrochlorobenzene	155-159	glutathione S-transferase pi 1	Homo sapiens	183-192
25324722-7	2014	To identify and characterize the potential inhibitory activity of 8-MOP, we studied the enzyme kinetics of the conjugation of 1-chloro-2,4-dinitrobenzene (CDNB) with GSH catalyzed by hGST P1-1.	Glutathione	166-169	glutathione S-transferase pi 1	Homo sapiens	183-192
25324722-8	2014	We report here that 8-MOP competitively inhibited hGST P1-1 relative to CDNB, but there was an uncompetitive inhibition relative to GSH.	Methoxsalen	20-25	glutathione S-transferase pi 1	Homo sapiens	50-59
24289107-4	2014	This exploratory study was designed to correlate the mRNA expression levels of candidate genes mainly involved in the doxorubicin pathway (ABCB1, GSTP1, TOPO2alpha, BCL2, PKCbetaII) with the outcome of 54 patients with DLBCL undergoing a dose-dense R-CHOP regimen.	Doxorubicin	118-129	glutathione S-transferase pi 1	Homo sapiens	146-151
25010864-0	2014	Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines.	Platinum	57-65	glutathione S-transferase pi 1	Homo sapiens	0-28
25010864-0	2014	Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines.	Platinum	57-65	glutathione S-transferase pi 1	Homo sapiens	30-35
25010864-2	2014	Platinum drugs are metabolised by glutathione S-transferase P1 (GSTP1), which is abundantly, but variably expressed in ovarian tumours.	Platinum	0-8	glutathione S-transferase pi 1	Homo sapiens	34-62
25010864-2	2014	Platinum drugs are metabolised by glutathione S-transferase P1 (GSTP1), which is abundantly, but variably expressed in ovarian tumours.	Platinum	0-8	glutathione S-transferase pi 1	Homo sapiens	64-69
25010864-4	2014	METHODS: Glutathione S-transferase P1 was stably deleted in A2780 and expression significantly reduced in cisplatin-resistant A2780DPP cells using Mission shRNA constructs, and MTT assays used to compare chemosensitivity to chemotherapy drugs used to treat ovarian cancer.	Cisplatin	106-115	glutathione S-transferase pi 1	Homo sapiens	9-37
25010864-4	2014	METHODS: Glutathione S-transferase P1 was stably deleted in A2780 and expression significantly reduced in cisplatin-resistant A2780DPP cells using Mission shRNA constructs, and MTT assays used to compare chemosensitivity to chemotherapy drugs used to treat ovarian cancer.	monooxyethylene trimethylolpropane tristearate	177-180	glutathione S-transferase pi 1	Homo sapiens	9-37
25010864-7	2014	RESULTS: Glutathione S-transferase P1 knockdown selectively influenced cisplatin and carboplatin chemosensitivity (2.3- and 4.83-fold change in IC50, respectively).	Cisplatin	71-80	glutathione S-transferase pi 1	Homo sapiens	9-37
25010864-7	2014	RESULTS: Glutathione S-transferase P1 knockdown selectively influenced cisplatin and carboplatin chemosensitivity (2.3- and 4.83-fold change in IC50, respectively).	Carboplatin	85-96	glutathione S-transferase pi 1	Homo sapiens	9-37
25010864-10	2014	CONCLUSIONS: Glutathione S-transferase P1 has an important role in cisplatin and carboplatin metabolism in ovarian cancer cells.	Cisplatin	67-76	glutathione S-transferase pi 1	Homo sapiens	13-41
25010864-10	2014	CONCLUSIONS: Glutathione S-transferase P1 has an important role in cisplatin and carboplatin metabolism in ovarian cancer cells.	Carboplatin	81-92	glutathione S-transferase pi 1	Homo sapiens	13-41
25010864-11	2014	Inter-tumour differences in GSTP1 expression may therefore influence response to platinum-based chemotherapy in ovarian cancer patients.	Platinum	81-89	glutathione S-transferase pi 1	Homo sapiens	28-33
25008252-5	2014	However, some of them e.g. cyanidin-3-O-rutinoside consistently decreased the level of GSTP1 mRNA in all tested cultures.	cyanidin 3-O-rutinoside betaine	27-50	glutathione S-transferase pi 1	Homo sapiens	87-92
24914470-5	2014	Luteolin inhibited TCDD-induced protein expression of phase I enzyme cytochrome P450 1A1 (CYP1A1), phase II enzymes NAD(P)H: quinone oxidoreductase-1 (NQO1) and glutathione-S-transferase P1 (GSTP1) in HepG2, Hepa1c1c7 and RL-34 cells in a dose-dependent manner.	Polychlorinated Dibenzodioxins	19-23	glutathione S-transferase pi 1	Homo sapiens	161-189
24914470-5	2014	Luteolin inhibited TCDD-induced protein expression of phase I enzyme cytochrome P450 1A1 (CYP1A1), phase II enzymes NAD(P)H: quinone oxidoreductase-1 (NQO1) and glutathione-S-transferase P1 (GSTP1) in HepG2, Hepa1c1c7 and RL-34 cells in a dose-dependent manner.	Polychlorinated Dibenzodioxins	19-23	glutathione S-transferase pi 1	Homo sapiens	191-196
24914470-7	2014	In tert-butylhydroquinone treated cells, luteolin dose-dependently inhibited NQO1, GSTP1 and aldo-keto reductases (AKRs).	2-tert-butylhydroquinone	3-25	glutathione S-transferase pi 1	Homo sapiens	83-88
24970398-1	2014	Glutathione S-transferase pi-1 (GSTP-1) is a member of the glutathione S-transferase enzyme superfamily, which catalyzes the conjugation of electrophiles to glutathione during the process of detoxification.	Glutathione	59-70	glutathione S-transferase pi 1	Homo sapiens	0-30
24970398-1	2014	Glutathione S-transferase pi-1 (GSTP-1) is a member of the glutathione S-transferase enzyme superfamily, which catalyzes the conjugation of electrophiles to glutathione during the process of detoxification.	Glutathione	59-70	glutathione S-transferase pi 1	Homo sapiens	32-38
24970398-11	2014	Finally, knockdown of GSTP-1 promoted the sensitivity of SNU-407 cells to the anticancer agent 5-fluorouracil.	Fluorouracil	95-109	glutathione S-transferase pi 1	Homo sapiens	22-28
24584466-2	2014	The aim of the study was to examine the genetic polymorphism in cytochrome P450 2D6 (CYP2D6) and glutathione S-transferases pi 1 (GSTP1) with respect to organochlorine pesticides (OCPs) and metals in AD.	Hydrocarbons, Chlorinated	153-167	glutathione S-transferase pi 1	Homo sapiens	97-128
25101770-9	2014	These findings suggest a possible role of GSTP1 in the detoxification of arsenic.	Arsenic	73-80	glutathione S-transferase pi 1	Homo sapiens	42-47
24729086-0	2014	The association between the GSTP1 A313G and GSTM1 null/present polymorphisms and the treatment response of the platinum-based chemotherapy in non-small cell lung cancer (NSCLC) patients: a meta-analysis.	Platinum	111-119	glutathione S-transferase pi 1	Homo sapiens	28-33
24729086-1	2014	The relationship between the GSTP1 A313G and GSTM1 null/present polymorphisms and the treatment response (TR) of platinum-based chemotherapy in non-small cell lung cancer (NSCLC) patients have been extensively investigated by many studies, but the results were inconsistent and inconclusive.	Platinum	113-121	glutathione S-transferase pi 1	Homo sapiens	29-34
24958519-0	2014	Genetic polymorphism of GSTP1 and ERCC1 correlated with response to platinum-based chemotherapy in non-small cell lung cancer.	Platinum	68-76	glutathione S-transferase pi 1	Homo sapiens	24-29
24958519-1	2014	The study aims to investigate whether the glutathione S transferase P1 (GSTP1) and excision repair cross-complementing group 1 (ERCC1) polymorphism influence the response to treatment with platinum-based chemotherapy in Chinese patients with non-small cell lung cancer.	Platinum	189-197	glutathione S-transferase pi 1	Homo sapiens	42-70
24958519-1	2014	The study aims to investigate whether the glutathione S transferase P1 (GSTP1) and excision repair cross-complementing group 1 (ERCC1) polymorphism influence the response to treatment with platinum-based chemotherapy in Chinese patients with non-small cell lung cancer.	Platinum	189-197	glutathione S-transferase pi 1	Homo sapiens	72-77
24958519-16	2014	GSTP1 and ERCC1 polymorphism are correlated with response to platinum-based chemotherapy and have prognostic value for TTP.	Platinum	61-69	glutathione S-transferase pi 1	Homo sapiens	0-5
24810314-5	2014	In colorectal tumor cells RM4819 has been shown to interact with GSTP1, and GSTP1 enzymatic activity is required for thiazolide-induced apoptosis.	thiazolide	117-127	glutathione S-transferase pi 1	Homo sapiens	76-81
24810314-8	2014	We further show that active thiazolides require caspase activation and GSTP1 expression in order to induce apoptosis.	thiazolides	28-39	glutathione S-transferase pi 1	Homo sapiens	71-76
24810314-9	2014	We demonstrate that increased glutathione (GSH) levels sensitize colon cancer cells to thiazolides, indicating that both GSTP1 enzymatic activity as well as GSH levels are critical factors in thiazolide-induced cell death.	Glutathione	30-41	glutathione S-transferase pi 1	Homo sapiens	121-126
24810314-9	2014	We demonstrate that increased glutathione (GSH) levels sensitize colon cancer cells to thiazolides, indicating that both GSTP1 enzymatic activity as well as GSH levels are critical factors in thiazolide-induced cell death.	Glutathione	43-46	glutathione S-transferase pi 1	Homo sapiens	121-126
24810314-9	2014	We demonstrate that increased glutathione (GSH) levels sensitize colon cancer cells to thiazolides, indicating that both GSTP1 enzymatic activity as well as GSH levels are critical factors in thiazolide-induced cell death.	thiazolides	87-98	glutathione S-transferase pi 1	Homo sapiens	121-126
24810314-9	2014	We demonstrate that increased glutathione (GSH) levels sensitize colon cancer cells to thiazolides, indicating that both GSTP1 enzymatic activity as well as GSH levels are critical factors in thiazolide-induced cell death.	thiazolide	87-97	glutathione S-transferase pi 1	Homo sapiens	121-126
25076909-1	2014	Glutathione S-transferases (GSTs) are phase II drug detoxifying enzymes that play an essential role in the maintenance of cell integrity and protection against DNA damage by catalyzing the conjugation of glutathione to a wide variety of exo- and endogenous electrophilic substrates.	Glutathione	204-215	glutathione S-transferase pi 1	Homo sapiens	28-32
24729086-11	2014	Our study suggested that the GSTP1 A313G and GSTM1 null/present polymorphisms could predict the treatment response of the platinum-based chemotherapy in NSCLC patients, especially in East-Asian patients.	Platinum	122-130	glutathione S-transferase pi 1	Homo sapiens	29-34
24584466-10	2014	It can be suggested that although CYP2D6*4 polymorphism is not a risk of AD, the CYP2D6*4 and GSTP1 polymorphism may interact with beta-HCH, dieldrin, and copper to influence the risk of AD.	beta-hexachlorocyclohexane	131-139	glutathione S-transferase pi 1	Homo sapiens	94-99
24584466-10	2014	It can be suggested that although CYP2D6*4 polymorphism is not a risk of AD, the CYP2D6*4 and GSTP1 polymorphism may interact with beta-HCH, dieldrin, and copper to influence the risk of AD.	Dieldrin	141-149	glutathione S-transferase pi 1	Homo sapiens	94-99
24584466-10	2014	It can be suggested that although CYP2D6*4 polymorphism is not a risk of AD, the CYP2D6*4 and GSTP1 polymorphism may interact with beta-HCH, dieldrin, and copper to influence the risk of AD.	Copper	155-161	glutathione S-transferase pi 1	Homo sapiens	94-99
24584466-2	2014	The aim of the study was to examine the genetic polymorphism in cytochrome P450 2D6 (CYP2D6) and glutathione S-transferases pi 1 (GSTP1) with respect to organochlorine pesticides (OCPs) and metals in AD.	Hydrocarbons, Chlorinated	153-167	glutathione S-transferase pi 1	Homo sapiens	130-135
24677708-0	2014	Synthesis and biological evaluation of 2-substituted-5-(4-nitrophenylsulfonamido)benzoxazoles as human GST P1-1 inhibitors, and description of the binding site features.	2-substituted-5-(4-nitrophenylsulfonamido)benzoxazoles	39-93	glutathione S-transferase pi 1	Homo sapiens	103-111
24847383-0	2014	ERCC1, XRCC1 and GSTP1 Single Nucleotide Polymorphisms and Survival of Patients with Colon Cancer Receiving Oxaliplatin-Based Adjuvant Chemotherapy.	Oxaliplatin	108-119	glutathione S-transferase pi 1	Homo sapiens	17-22
24677708-6	2014	Herein we report the design and synthesis of some novel sulfonamide-containing benzoxazoles, which are able to inhibit human GST P1-1.	Sulfonamides	56-67	glutathione S-transferase pi 1	Homo sapiens	125-133
24326871-7	2014	RESULTS: Three different shRNA oligonucleotides (shRNA255; shRNA554; shRNA593) targeting the coding sequence of GSTP1 mRNA and one negative control shRNA were constructed.	Oligonucleotides	31-47	glutathione S-transferase pi 1	Homo sapiens	112-117
24677708-6	2014	Herein we report the design and synthesis of some novel sulfonamide-containing benzoxazoles, which are able to inhibit human GST P1-1.	Benzoxazoles	79-91	glutathione S-transferase pi 1	Homo sapiens	125-133
24765164-0	2014	Long-term administration and efficacy of oxaliplatin with no neurotoxicity in a patient with rectal cancer: Association between neurotoxicity and the GSTP1 polymorphism.	Oxaliplatin	41-52	glutathione S-transferase pi 1	Homo sapiens	150-155
24677708-7	2014	Among the tested compounds, 2-(4-chlorobenzyl)-5-(4-nitrophenylsulfonamido)benzoxazole (5 f) was found as the most active hGST P1-1 inhibitor, with an IC50 value of 10.2 muM, showing potency similar to that of the reference drug ethacrynic acid.	2-(4-chlorobenzyl)-5-(4-nitrophenylsulfonamido)benzoxazole	28-86	glutathione S-transferase pi 1	Homo sapiens	122-131
24677708-7	2014	Among the tested compounds, 2-(4-chlorobenzyl)-5-(4-nitrophenylsulfonamido)benzoxazole (5 f) was found as the most active hGST P1-1 inhibitor, with an IC50 value of 10.2 muM, showing potency similar to that of the reference drug ethacrynic acid.	Ethacrynic Acid	229-244	glutathione S-transferase pi 1	Homo sapiens	122-131
24677708-8	2014	Molecular docking studies performed with CDocker revealed that the newly synthesized 2-substituted-5-(4-nitrophenylsulfonamido)benzoxazoles act as catalytic inhibitors of hGST P1-1 by binding to the H-site and generating conjugates with GSH to form S-(4-nitrophenyl)GSH (GS-BN complex) via nucleophilic aromatic substitution reaction.	2-substituted-5-(4-nitrophenylsulfonamido)benzoxazoles	85-139	glutathione S-transferase pi 1	Homo sapiens	171-180
24677708-8	2014	Molecular docking studies performed with CDocker revealed that the newly synthesized 2-substituted-5-(4-nitrophenylsulfonamido)benzoxazoles act as catalytic inhibitors of hGST P1-1 by binding to the H-site and generating conjugates with GSH to form S-(4-nitrophenyl)GSH (GS-BN complex) via nucleophilic aromatic substitution reaction.	Glutathione	237-240	glutathione S-transferase pi 1	Homo sapiens	171-180
24677708-8	2014	Molecular docking studies performed with CDocker revealed that the newly synthesized 2-substituted-5-(4-nitrophenylsulfonamido)benzoxazoles act as catalytic inhibitors of hGST P1-1 by binding to the H-site and generating conjugates with GSH to form S-(4-nitrophenyl)GSH (GS-BN complex) via nucleophilic aromatic substitution reaction.	s-(4-nitrophenyl)gsh	249-269	glutathione S-transferase pi 1	Homo sapiens	171-180
24765164-8	2014	In the present patient, the glutathione S-transferase P1 (GSTP1) gene polymorphism, which is involved in the detoxification of platinum drugs, was analyzed.	Platinum	127-135	glutathione S-transferase pi 1	Homo sapiens	28-56
24765164-8	2014	In the present patient, the glutathione S-transferase P1 (GSTP1) gene polymorphism, which is involved in the detoxification of platinum drugs, was analyzed.	Platinum	127-135	glutathione S-transferase pi 1	Homo sapiens	58-63
24765164-12	2014	Therefore, correlation between the GSTP1 polymorphism and oxaliplatin-induced neurotoxicity remains controversial.	Oxaliplatin	58-69	glutathione S-transferase pi 1	Homo sapiens	35-40
24552538-6	2014	The GSH conjugation was strongly increased by adding human GSTP1-1 in a wide range of GSH concentrations.	Glutathione	4-7	glutathione S-transferase pi 1	Homo sapiens	59-66
24552538-6	2014	The GSH conjugation was strongly increased by adding human GSTP1-1 in a wide range of GSH concentrations.	Glutathione	86-89	glutathione S-transferase pi 1	Homo sapiens	59-66
24344877-11	2014	RESULTS: SM-induced COPD individuals showed expression of GSTA1 2.51 +- 0.83-, GSTM1 2.84 +- 1.71- and GSTP1 5.61 +- 2.59-folds higher than those of controls that revealed.	Mustard Gas	9-11	glutathione S-transferase pi 1	Homo sapiens	103-108
24571427-7	2014	Only a cysteine adduct and a putative cross-linking adduct were detected on glutathione S-transferase Pi (GSTP).	Cysteine	7-15	glutathione S-transferase pi 1	Homo sapiens	76-104
24571427-7	2014	Only a cysteine adduct and a putative cross-linking adduct were detected on glutathione S-transferase Pi (GSTP).	Cysteine	7-15	glutathione S-transferase pi 1	Homo sapiens	106-110
24358460-2	2014	The method is based on electrostatic modulation of the anion-exchange kinetics of a polypyrrole bilayer film deposited on platinum-microelectrodes to which a synthetic single-stranded 15-mer GSTP-1 promoter probe DNA has been attached (DNA detector).	polypyrrole	84-95	glutathione S-transferase pi 1	Homo sapiens	191-197
24521039-0	2014	Nitric oxide (NO) releasing poly ADP-ribose polymerase 1 (PARP-1) inhibitors targeted to glutathione S-transferase P1-overexpressing cancer cells.	Nitric Oxide	0-12	glutathione S-transferase pi 1	Homo sapiens	89-117
24521039-4	2014	The resulting prodrugs are activated by glutathione in a reaction accelerated by glutathione S-transferase P1 (GSTP1), an enzyme frequently overexpressed in cancers.	Glutathione	40-51	glutathione S-transferase pi 1	Homo sapiens	81-109
24521039-4	2014	The resulting prodrugs are activated by glutathione in a reaction accelerated by glutathione S-transferase P1 (GSTP1), an enzyme frequently overexpressed in cancers.	Glutathione	40-51	glutathione S-transferase pi 1	Homo sapiens	111-116
24397869-4	2014	Modifications of cysteine residues of (i) human glutathione-S-transferase P1-1 (GSTP1) and (ii) the schistosomiasis drug target thioredoxin glutathione reductase (TGR) were studied.	Cysteine	17-25	glutathione S-transferase pi 1	Homo sapiens	80-85
24397869-8	2014	Treatment of living neuronal cells with CysNO, to induce nitrosative stress, caused levels of S-nitrosylation and S-oxidation of GSTP1 comparable to those of cell-free studies.	S-nitrosocysteine	40-45	glutathione S-transferase pi 1	Homo sapiens	129-134
25606397-1	2014	Glutathione S-transferases (GSTs) belong to a super family of phase II detoxification enzymes, which play an important role in protecting cells from damage caused by endogenous and exogenous compounds by conjugating reactive intermediates with glutathione to produce less reactive water-soluble compounds.	Glutathione	244-255	glutathione S-transferase pi 1	Homo sapiens	28-32
24457959-2	2014	The dissociation constant of the heterocomplex is K(d)=0.3 muM; however the binding affinity strongly decreases when the active site of GSTP1-1 is occupied by the substrate GSH (K(d)>=2.6 muM) or is inactivated by oxidation (Kd=1.7 muM).	Glutathione	173-176	glutathione S-transferase pi 1	Homo sapiens	136-143
24457959-3	2014	This indicates that GSTP1-1"s TRAF2-binding region involves the GSH-binding site.	Glutathione	64-67	glutathione S-transferase pi 1	Homo sapiens	20-27
24457959-4	2014	The GSTP1-1 inhibitor NBDHEX further decreases the complex"s binding affinity, as compared with when GSH is the only ligand; this suggests that the hydrophobic portion of the GSTP1-1 active site also contributes to the interaction.	Glutathione	101-104	glutathione S-transferase pi 1	Homo sapiens	4-11
24457959-4	2014	The GSTP1-1 inhibitor NBDHEX further decreases the complex"s binding affinity, as compared with when GSH is the only ligand; this suggests that the hydrophobic portion of the GSTP1-1 active site also contributes to the interaction.	Glutathione	101-104	glutathione S-transferase pi 1	Homo sapiens	175-182
24457959-10	2014	Moreover, GSH"s intracellular content was so high that it always saturated GSTP1-1.	Glutathione	10-13	glutathione S-transferase pi 1	Homo sapiens	75-82
25606397-1	2014	Glutathione S-transferases (GSTs) belong to a super family of phase II detoxification enzymes, which play an important role in protecting cells from damage caused by endogenous and exogenous compounds by conjugating reactive intermediates with glutathione to produce less reactive water-soluble compounds.	Water	281-286	glutathione S-transferase pi 1	Homo sapiens	28-32
24185126-0	2014	Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.	Glutathione	16-27	glutathione S-transferase pi 1	Homo sapiens	42-48
24254297-5	2014	Logistic regression analyses showed significant risk for CRC associated with GSTP1 homozygotes for Val-105 (OR 4.82; 95 % CI 1.97-11.80) or for individuals who possessed at least one Val-105 allele (OR 2.54; 95 % CI 1.751-3.703).	Valine	99-102	glutathione S-transferase pi 1	Homo sapiens	77-82
24185126-0	2014	Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.	Clozapine	113-122	glutathione S-transferase pi 1	Homo sapiens	42-48
24185126-0	2014	Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.	Diclofenac	124-134	glutathione S-transferase pi 1	Homo sapiens	42-48
24185126-0	2014	Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.	Acetaminophen	139-152	glutathione S-transferase pi 1	Homo sapiens	42-48
24185126-3	2014	Three allelic variants of hGSTP1-1 containing an Ile105Val or Ala114Val substitution, or a combination of both, have been the most widely studied and showed different activity when compared to wild-type hGSTP1-1*A (Ile105/Ala114).	ile105val	49-58	glutathione S-transferase pi 1	Homo sapiens	26-34
24185126-3	2014	Three allelic variants of hGSTP1-1 containing an Ile105Val or Ala114Val substitution, or a combination of both, have been the most widely studied and showed different activity when compared to wild-type hGSTP1-1*A (Ile105/Ala114).	ile105val	49-58	glutathione S-transferase pi 1	Homo sapiens	26-32
24185126-8	2014	The different hGSTP1-1 mutants showed slightly altered regioselectivities in formation of individual GSH conjugates of clozapine which suggests that the binding orientation of the reactive nitrenium ion of clozapine is affected by the mutations.	Glutathione	101-104	glutathione S-transferase pi 1	Homo sapiens	14-22
24185126-8	2014	The different hGSTP1-1 mutants showed slightly altered regioselectivities in formation of individual GSH conjugates of clozapine which suggests that the binding orientation of the reactive nitrenium ion of clozapine is affected by the mutations.	Clozapine	119-128	glutathione S-transferase pi 1	Homo sapiens	14-22
24185126-8	2014	The different hGSTP1-1 mutants showed slightly altered regioselectivities in formation of individual GSH conjugates of clozapine which suggests that the binding orientation of the reactive nitrenium ion of clozapine is affected by the mutations.	nitrenium	189-198	glutathione S-transferase pi 1	Homo sapiens	14-22
24185126-8	2014	The different hGSTP1-1 mutants showed slightly altered regioselectivities in formation of individual GSH conjugates of clozapine which suggests that the binding orientation of the reactive nitrenium ion of clozapine is affected by the mutations.	Clozapine	206-215	glutathione S-transferase pi 1	Homo sapiens	14-22
24185126-9	2014	For diclofenac, a significant decrease in activity in GSH-conjugation of diclofenac 1",4"-quinone imine was observed for variants hGSTP1-1*B (Val105/Ala114) and hGSTP1-1*C (Val105/Val114).	Diclofenac	4-14	glutathione S-transferase pi 1	Homo sapiens	130-136
24185126-9	2014	For diclofenac, a significant decrease in activity in GSH-conjugation of diclofenac 1",4"-quinone imine was observed for variants hGSTP1-1*B (Val105/Ala114) and hGSTP1-1*C (Val105/Val114).	Diclofenac	4-14	glutathione S-transferase pi 1	Homo sapiens	130-138
24185126-9	2014	For diclofenac, a significant decrease in activity in GSH-conjugation of diclofenac 1",4"-quinone imine was observed for variants hGSTP1-1*B (Val105/Ala114) and hGSTP1-1*C (Val105/Val114).	Glutathione	54-57	glutathione S-transferase pi 1	Homo sapiens	130-136
24185126-9	2014	For diclofenac, a significant decrease in activity in GSH-conjugation of diclofenac 1",4"-quinone imine was observed for variants hGSTP1-1*B (Val105/Ala114) and hGSTP1-1*C (Val105/Val114).	Glutathione	54-57	glutathione S-transferase pi 1	Homo sapiens	130-138
24185126-9	2014	For diclofenac, a significant decrease in activity in GSH-conjugation of diclofenac 1",4"-quinone imine was observed for variants hGSTP1-1*B (Val105/Ala114) and hGSTP1-1*C (Val105/Val114).	diclofenac 1",4"-quinone imine	73-103	glutathione S-transferase pi 1	Homo sapiens	130-136
24185126-9	2014	For diclofenac, a significant decrease in activity in GSH-conjugation of diclofenac 1",4"-quinone imine was observed for variants hGSTP1-1*B (Val105/Ala114) and hGSTP1-1*C (Val105/Val114).	diclofenac 1",4"-quinone imine	73-103	glutathione S-transferase pi 1	Homo sapiens	130-138
24974181-3	2014	In addition to catalytic detoxification, other properties so far ascribed to GSTP include chaperone functions, regulation of nitric oxide pathways, regulation of a variety of kinase signaling pathways, and participation in the forward reaction of protein S-glutathionylation.	Nitric Oxide	125-137	glutathione S-transferase pi 1	Homo sapiens	77-81
24696865-1	2014	This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg).	Glutathione	60-71	glutathione S-transferase pi 1	Homo sapiens	108-113
24696865-1	2014	This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg).	Glutathione	73-76	glutathione S-transferase pi 1	Homo sapiens	108-113
25101650-9	2014	We found significantly high levels of beta-HCH, dieldrin and pp"-DDE in the CYP2D6*4 mt allelic variants, beta-HCH and pp"-DDE in the GSTP1*B allelic variants and dieldrin in the GSTP1*C allelic variants when comparing CYP2D6*4 non-mt, GSTP1 non-*B and GSTP1 non-*C allelic variants in patients of PD respectively.	pp"-dde	119-126	glutathione S-transferase pi 1	Homo sapiens	134-139
25101650-10	2014	CONCLUSION: This study demonstrates that the CYP2D6*4 and GSTP1 genes may be considered as candidate genes for PD and they may also interact with beta- HCH, dieldrin and pp"-DDE to influence the risk for PD.	beta-hexachlorocyclohexane	146-155	glutathione S-transferase pi 1	Homo sapiens	58-63
25101650-10	2014	CONCLUSION: This study demonstrates that the CYP2D6*4 and GSTP1 genes may be considered as candidate genes for PD and they may also interact with beta- HCH, dieldrin and pp"-DDE to influence the risk for PD.	Dieldrin	157-165	glutathione S-transferase pi 1	Homo sapiens	58-63
25101650-10	2014	CONCLUSION: This study demonstrates that the CYP2D6*4 and GSTP1 genes may be considered as candidate genes for PD and they may also interact with beta- HCH, dieldrin and pp"-DDE to influence the risk for PD.	pp"-dde	170-177	glutathione S-transferase pi 1	Homo sapiens	58-63
25389438-0	2014	The Effects of Lycopene on the Methylation of the GSTP1 Promoter and Global Methylation in Prostatic Cancer Cell Lines PC3 and LNCaP.	Lycopene	15-23	glutathione S-transferase pi 1	Homo sapiens	50-55
25389438-3	2014	However, it is unknown whether lycopene reactivates the tumor suppressor gene glutathioneS-transferase-pi (GSTP1) by demethylation of the hypermethylated CpGs that act to silence the GSTP1 promoter.	Lycopene	31-39	glutathione S-transferase pi 1	Homo sapiens	107-112
25389438-3	2014	However, it is unknown whether lycopene reactivates the tumor suppressor gene glutathioneS-transferase-pi (GSTP1) by demethylation of the hypermethylated CpGs that act to silence the GSTP1 promoter.	Lycopene	31-39	glutathione S-transferase pi 1	Homo sapiens	183-188
25389438-4	2014	Here, we demonstrated that lycopene treatment significantly decreased the methylation levels of the GSTP1 promoter and increased the mRNA and protein levels of GSTP1 in an androgen-independent PC-3 cell line.	Lycopene	27-35	glutathione S-transferase pi 1	Homo sapiens	100-105
25389438-4	2014	Here, we demonstrated that lycopene treatment significantly decreased the methylation levels of the GSTP1 promoter and increased the mRNA and protein levels of GSTP1 in an androgen-independent PC-3 cell line.	Lycopene	27-35	glutathione S-transferase pi 1	Homo sapiens	160-165
24254297-5	2014	Logistic regression analyses showed significant risk for CRC associated with GSTP1 homozygotes for Val-105 (OR 4.82; 95 % CI 1.97-11.80) or for individuals who possessed at least one Val-105 allele (OR 2.54; 95 % CI 1.751-3.703).	Valine	183-186	glutathione S-transferase pi 1	Homo sapiens	77-82
22833520-6	2014	Silencing of GSTP1 using siRNA approach in normal human prostate epithelial RWPE1 cells caused increased intracellular production of ROS and higher susceptibility of cells to H2 O2 -mediated oxidative stress.	Hydrogen Peroxide	175-180	glutathione S-transferase pi 1	Homo sapiens	13-18
22833520-8	2014	Induction of GSTP1 activity lowered endogenous ROS levels in LNCaP-pLPCX-GSTP1 cells, and when exposed to H2 O2 , these cells exhibited significantly reduced production of ROS and 8-OHdG levels, compared to vector control LNCaP-pLPCX cells.	Reactive Oxygen Species	47-50	glutathione S-transferase pi 1	Homo sapiens	13-18
22833520-3	2014	Silencing of GSTP1 can increase generation of reactive oxygen species (ROS) and DNA damage in cells.	Reactive Oxygen Species	46-69	glutathione S-transferase pi 1	Homo sapiens	13-18
22833520-8	2014	Induction of GSTP1 activity lowered endogenous ROS levels in LNCaP-pLPCX-GSTP1 cells, and when exposed to H2 O2 , these cells exhibited significantly reduced production of ROS and 8-OHdG levels, compared to vector control LNCaP-pLPCX cells.	Reactive Oxygen Species	47-50	glutathione S-transferase pi 1	Homo sapiens	73-78
22833520-3	2014	Silencing of GSTP1 can increase generation of reactive oxygen species (ROS) and DNA damage in cells.	Reactive Oxygen Species	71-74	glutathione S-transferase pi 1	Homo sapiens	13-18
22833520-8	2014	Induction of GSTP1 activity lowered endogenous ROS levels in LNCaP-pLPCX-GSTP1 cells, and when exposed to H2 O2 , these cells exhibited significantly reduced production of ROS and 8-OHdG levels, compared to vector control LNCaP-pLPCX cells.	Hydrogen Peroxide	106-111	glutathione S-transferase pi 1	Homo sapiens	13-18
22833520-8	2014	Induction of GSTP1 activity lowered endogenous ROS levels in LNCaP-pLPCX-GSTP1 cells, and when exposed to H2 O2 , these cells exhibited significantly reduced production of ROS and 8-OHdG levels, compared to vector control LNCaP-pLPCX cells.	Hydrogen Peroxide	106-111	glutathione S-transferase pi 1	Homo sapiens	73-78
22833520-5	2014	We found significantly elevated (103%; P < 0.0001) levels of 8-oxo-2"-deoxogunosine (8-OHdG), an oxidative DNA damage marker, in adenocarcinomas, compared to benign counterparts, which positively correlated (r = 0.2) with loss of GSTP1 activity (34%; P < 0.0001).	8-oxo-2"-deoxogunosine	64-86	glutathione S-transferase pi 1	Homo sapiens	233-238
22833520-8	2014	Induction of GSTP1 activity lowered endogenous ROS levels in LNCaP-pLPCX-GSTP1 cells, and when exposed to H2 O2 , these cells exhibited significantly reduced production of ROS and 8-OHdG levels, compared to vector control LNCaP-pLPCX cells.	Reactive Oxygen Species	172-175	glutathione S-transferase pi 1	Homo sapiens	13-18
22833520-5	2014	We found significantly elevated (103%; P < 0.0001) levels of 8-oxo-2"-deoxogunosine (8-OHdG), an oxidative DNA damage marker, in adenocarcinomas, compared to benign counterparts, which positively correlated (r = 0.2) with loss of GSTP1 activity (34%; P < 0.0001).	8-ohdg	88-94	glutathione S-transferase pi 1	Homo sapiens	233-238
22833520-6	2014	Silencing of GSTP1 using siRNA approach in normal human prostate epithelial RWPE1 cells caused increased intracellular production of ROS and higher susceptibility of cells to H2 O2 -mediated oxidative stress.	Reactive Oxygen Species	133-136	glutathione S-transferase pi 1	Homo sapiens	13-18
22833520-8	2014	Induction of GSTP1 activity lowered endogenous ROS levels in LNCaP-pLPCX-GSTP1 cells, and when exposed to H2 O2 , these cells exhibited significantly reduced production of ROS and 8-OHdG levels, compared to vector control LNCaP-pLPCX cells.	8-ohdg	180-186	glutathione S-transferase pi 1	Homo sapiens	13-18
22833520-9	2014	Furthermore, exposure of LNCaP cells to green tea polyphenols caused reexpression of GSTP1, which protected the cells from H2 O2 -mediated DNA damage through decreased ROS production compared to nonexposed cells.	Polyphenols	50-61	glutathione S-transferase pi 1	Homo sapiens	85-90
22833520-9	2014	Furthermore, exposure of LNCaP cells to green tea polyphenols caused reexpression of GSTP1, which protected the cells from H2 O2 -mediated DNA damage through decreased ROS production compared to nonexposed cells.	Hydrogen Peroxide	123-128	glutathione S-transferase pi 1	Homo sapiens	85-90
22833520-9	2014	Furthermore, exposure of LNCaP cells to green tea polyphenols caused reexpression of GSTP1, which protected the cells from H2 O2 -mediated DNA damage through decreased ROS production compared to nonexposed cells.	Reactive Oxygen Species	168-171	glutathione S-transferase pi 1	Homo sapiens	85-90
23812950-7	2013	RESULTS: In single-locus analysis, Ile/Val and Ile/Val+Val/Val genotypes of the GSTP1 Ile105Val (rs1695) polymorphism reached statistical significance with grade 2-4 anemia (P=0.019, P=0.027).	ile105val	86-95	glutathione S-transferase pi 1	Homo sapiens	80-85
24266513-5	2013	Circular dichroism spectroscopy, acrylamide quenching, and amide hydrogen-deuterium exchange mass spectrometry experiments indicate that the loss of activity is caused by the introduction of local disorder at the active site of GSTP1-1.	Acrylamide	33-43	glutathione S-transferase pi 1	Homo sapiens	228-235
24266513-5	2013	Circular dichroism spectroscopy, acrylamide quenching, and amide hydrogen-deuterium exchange mass spectrometry experiments indicate that the loss of activity is caused by the introduction of local disorder at the active site of GSTP1-1.	Amides	38-43	glutathione S-transferase pi 1	Homo sapiens	228-235
24266513-5	2013	Circular dichroism spectroscopy, acrylamide quenching, and amide hydrogen-deuterium exchange mass spectrometry experiments indicate that the loss of activity is caused by the introduction of local disorder at the active site of GSTP1-1.	Hydrogen	65-73	glutathione S-transferase pi 1	Homo sapiens	228-235
24266513-5	2013	Circular dichroism spectroscopy, acrylamide quenching, and amide hydrogen-deuterium exchange mass spectrometry experiments indicate that the loss of activity is caused by the introduction of local disorder at the active site of GSTP1-1.	Deuterium	74-83	glutathione S-transferase pi 1	Homo sapiens	228-235
24083800-4	2013	Addition of pooled human liver cytosol and recombinant hGSTA1-1, hGSTM1-1, and hGSTP1-1 to incubations of diclofenac with human liver microsomes or purified CYP102A1M11 L437N as a model system significantly increased total GSH-conjugation.	Diclofenac	106-116	glutathione S-transferase pi 1	Homo sapiens	79-87
24083800-5	2013	The strongest increase of total GSH-conjugation was observed by adding hGSTP1-1, whereas hGSTM1-1 and hGSTA1-1 showed lower activity.	Glutathione	32-35	glutathione S-transferase pi 1	Homo sapiens	71-79
24083800-7	2013	When considering the effects of hGSTs on GSH-conjugation of the different quinoneimines of diclofenac, it was found that hGSTP1-1 showed the highest activity in GSH-conjugation of the quinoneimine derived from 5-hydroxydiclofenac (5-OH-DF).	Glutathione	41-44	glutathione S-transferase pi 1	Homo sapiens	121-129
24083800-7	2013	When considering the effects of hGSTs on GSH-conjugation of the different quinoneimines of diclofenac, it was found that hGSTP1-1 showed the highest activity in GSH-conjugation of the quinoneimine derived from 5-hydroxydiclofenac (5-OH-DF).	quinoneimines	74-87	glutathione S-transferase pi 1	Homo sapiens	121-129
24083800-7	2013	When considering the effects of hGSTs on GSH-conjugation of the different quinoneimines of diclofenac, it was found that hGSTP1-1 showed the highest activity in GSH-conjugation of the quinoneimine derived from 5-hydroxydiclofenac (5-OH-DF).	Diclofenac	91-101	glutathione S-transferase pi 1	Homo sapiens	121-129
24083800-7	2013	When considering the effects of hGSTs on GSH-conjugation of the different quinoneimines of diclofenac, it was found that hGSTP1-1 showed the highest activity in GSH-conjugation of the quinoneimine derived from 5-hydroxydiclofenac (5-OH-DF).	Glutathione	161-164	glutathione S-transferase pi 1	Homo sapiens	121-129
24083800-7	2013	When considering the effects of hGSTs on GSH-conjugation of the different quinoneimines of diclofenac, it was found that hGSTP1-1 showed the highest activity in GSH-conjugation of the quinoneimine derived from 5-hydroxydiclofenac (5-OH-DF).	quinoneimine	74-86	glutathione S-transferase pi 1	Homo sapiens	121-129
24083800-7	2013	When considering the effects of hGSTs on GSH-conjugation of the different quinoneimines of diclofenac, it was found that hGSTP1-1 showed the highest activity in GSH-conjugation of the quinoneimine derived from 5-hydroxydiclofenac (5-OH-DF).	5-hydroxydiclofenac	210-229	glutathione S-transferase pi 1	Homo sapiens	121-129
24083800-7	2013	When considering the effects of hGSTs on GSH-conjugation of the different quinoneimines of diclofenac, it was found that hGSTP1-1 showed the highest activity in GSH-conjugation of the quinoneimine derived from 5-hydroxydiclofenac (5-OH-DF).	5-oh-df	231-238	glutathione S-transferase pi 1	Homo sapiens	121-129
24083800-11	2013	hGSTP1-1 showed the highest activity for the formation of these minor GSH-conjugates.	Glutathione	70-73	glutathione S-transferase pi 1	Homo sapiens	0-8
24370292-0	2013	[Association between GSTP1, GSTM1, GSTT1 genetic polymorphisms and urinary styrene phenyl hydroxyethyl mercapturic acids level].	styrene phenyl hydroxyethyl mercapturic acids	75-120	glutathione S-transferase pi 1	Homo sapiens	21-26
24066958-1	2013	Canfosfamide (TLK286, TELCYTA) is a prodrug that upon activation by glutathione transferase P1-1 (GST P1-1) yields an anticancer alkylating agent and a glutathione derivative.	TER 286	0-12	glutathione S-transferase pi 1	Homo sapiens	98-106
24066958-1	2013	Canfosfamide (TLK286, TELCYTA) is a prodrug that upon activation by glutathione transferase P1-1 (GST P1-1) yields an anticancer alkylating agent and a glutathione derivative.	TER 286	14-20	glutathione S-transferase pi 1	Homo sapiens	98-106
24066958-1	2013	Canfosfamide (TLK286, TELCYTA) is a prodrug that upon activation by glutathione transferase P1-1 (GST P1-1) yields an anticancer alkylating agent and a glutathione derivative.	Glutathione	68-79	glutathione S-transferase pi 1	Homo sapiens	98-106
24066958-2	2013	The rationale underlying the use of TLK286 in chemotherapy is that tumor cells overexpressing GST P1-1 will be locally exposed to the released alkylating agent with limited collateral toxicity to the surrounding normal tissues.	TER 286	36-42	glutathione S-transferase pi 1	Homo sapiens	94-102
24066958-5	2013	Here, we propose a mechanism for the TLK286 activation by GST P1-1 on the basis of density functional theory (DFT) and on potential of mean force (PMF) calculations.	TER 286	37-43	glutathione S-transferase pi 1	Homo sapiens	58-66
24370292-7	2013	CONCLUSION: The genetic polymorphisms of GSTP1 and GSTM1 may be related to urinary level of PHEMAs in workers exposed to styrene.	Styrene	121-128	glutathione S-transferase pi 1	Homo sapiens	41-46
24084344-0	2013	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms.	Polycyclic Aromatic Hydrocarbons	59-91	glutathione S-transferase pi 1	Homo sapiens	151-156
23842854-10	2013	In conclusion, the GSTP1 expression is a good predictor of prognosis, and it may be closely related to the chemotherapeutic efficacy of 5-FU plus cisplatin in ESCC patients.	Fluorouracil	136-140	glutathione S-transferase pi 1	Homo sapiens	19-24
23842854-10	2013	In conclusion, the GSTP1 expression is a good predictor of prognosis, and it may be closely related to the chemotherapeutic efficacy of 5-FU plus cisplatin in ESCC patients.	Cisplatin	146-155	glutathione S-transferase pi 1	Homo sapiens	19-24
23811488-11	2013	CONCLUSION: This updated meta-analysis suggests that the GSTP1 Ile105Val polymorphism may not be associated with CRC risk, while the observed decrease in risk of CRC may be due to small-study bias.	ile105val	63-72	glutathione S-transferase pi 1	Homo sapiens	57-62
23916688-8	2013	Co-expression of hGSTP1-1 protected yeast from BM3 M11 induced growth inhibition in presence of clozapine, whereas similar expression levels of hGSTA1-1 and hGSTM1-1 did not.	Clozapine	96-105	glutathione S-transferase pi 1	Homo sapiens	17-25
23769903-5	2013	RESULTS: We identified chlorophyllide, merbromine, hexachlorophene, and ethacrynic acid as the most effective GST P1-1 inhibitors with IC50 values in the low micromolar range.	Chlorophyllides	23-37	glutathione S-transferase pi 1	Homo sapiens	110-118
23769903-5	2013	RESULTS: We identified chlorophyllide, merbromine, hexachlorophene, and ethacrynic acid as the most effective GST P1-1 inhibitors with IC50 values in the low micromolar range.	Merbromin	39-49	glutathione S-transferase pi 1	Homo sapiens	110-118
23769903-5	2013	RESULTS: We identified chlorophyllide, merbromine, hexachlorophene, and ethacrynic acid as the most effective GST P1-1 inhibitors with IC50 values in the low micromolar range.	Hexachlorophene	51-66	glutathione S-transferase pi 1	Homo sapiens	110-118
23769903-5	2013	RESULTS: We identified chlorophyllide, merbromine, hexachlorophene, and ethacrynic acid as the most effective GST P1-1 inhibitors with IC50 values in the low micromolar range.	Ethacrynic Acid	72-87	glutathione S-transferase pi 1	Homo sapiens	110-118
23769903-7	2013	In distinction from the other inhibitors, which showed conventional inhibition patterns, the competitive inhibitor ethacrynic acid elicited strong kinetic cooperativity in the glutathione saturation of GST P1-1.	Ethacrynic Acid	115-130	glutathione S-transferase pi 1	Homo sapiens	202-210
23769903-7	2013	In distinction from the other inhibitors, which showed conventional inhibition patterns, the competitive inhibitor ethacrynic acid elicited strong kinetic cooperativity in the glutathione saturation of GST P1-1.	Glutathione	176-187	glutathione S-transferase pi 1	Homo sapiens	202-210
23804706-0	2013	Ethacrynic acid oxadiazole analogs induce apoptosis in malignant hematologic cells through downregulation of Mcl-1 and c-FLIP, which was attenuated by GSTP1-1.	ethacrynic acid oxadiazole	0-26	glutathione S-transferase pi 1	Homo sapiens	151-158
23804706-1	2013	Ethacrynic acid, a diuretic, inhibits glutathione S-transferase P1-1 (GSTP1-1) activity and induces cell death in malignant cells at high concentrations.	Ethacrynic Acid	0-15	glutathione S-transferase pi 1	Homo sapiens	70-77
23804706-12	2013	These data suggest that the methylene group plays an important role in the downregulation of c-FLIP and Mcl-1 proteins and apoptosis induction, which is inactivated by GSTP1-1 by forming GSH conjugates.	Glutathione	187-190	glutathione S-transferase pi 1	Homo sapiens	168-175
23846855-4	2013	In concurrence with in silico data, MC exposure significantly up regulates the expression and activity of AHR, CYP1A1 and glutathione S-transferase P1-1 (GSTP1-1) and down regulates the expression of CREB, AMPA and NMDA receptors in hUCBSC-derived neuronal cells at various maturity (0, 2, 4, 8 days of differentiation).	Methylcholanthrene	36-38	glutathione S-transferase pi 1	Homo sapiens	154-161
23695028-0	2013	Association between GSTP1 Ile105Val polymorphism and oxaliplatin-induced neuropathy: a systematic review and meta-analysis.	Oxaliplatin	53-64	glutathione S-transferase pi 1	Homo sapiens	20-25
24137384-6	2013	Patients with the GSTP1-105 A/A genotype had poor responses to mFOLFOX6 treatment compared with those with the GSTP1-105 A/G and G/G genotypes (P=0.01).	mfolfox6	63-71	glutathione S-transferase pi 1	Homo sapiens	18-23
24137384-11	2013	GSTP1-105 and GSTM1 genotypes may be useful markers of severe peripheral neuropathy in MCRC patients treated with 5-FU/oxaliplatin as first-line chemotherapy.	Fluorouracil	114-118	glutathione S-transferase pi 1	Homo sapiens	0-5
24137384-11	2013	GSTP1-105 and GSTM1 genotypes may be useful markers of severe peripheral neuropathy in MCRC patients treated with 5-FU/oxaliplatin as first-line chemotherapy.	Oxaliplatin	119-130	glutathione S-transferase pi 1	Homo sapiens	0-5
23695028-1	2013	BACKGROUND AND AIMS: The association between glutathione-S-transferase P1 (GSTP1) Ile105Val polymorphism and oxaliplatin-induced neuropathy has been investigated in a number of published studies.	Oxaliplatin	109-120	glutathione S-transferase pi 1	Homo sapiens	45-73
23695028-1	2013	BACKGROUND AND AIMS: The association between glutathione-S-transferase P1 (GSTP1) Ile105Val polymorphism and oxaliplatin-induced neuropathy has been investigated in a number of published studies.	Oxaliplatin	109-120	glutathione S-transferase pi 1	Homo sapiens	75-80
23695028-3	2013	To assess the relationship between GSTP1 gene Ile105Val polymorphism and its susceptibility to oxaliplatin-induced neuropathy, a meta-analysis of previous studies was conducted.	Oxaliplatin	95-106	glutathione S-transferase pi 1	Homo sapiens	35-40
23765758-1	2013	Glutathione S-transferase P1 (GSTP1) gene Ile105Val polymorphism has been suggested to be involved in the development of cancer.	ile105val	42-51	glutathione S-transferase pi 1	Homo sapiens	0-28
23685245-4	2013	Moreover, the expression of GPx1, GSTP1 and gamma-glutamyl cysteine synthase (gamma-GCS) were enhanced, and cytochrome P450 2E1 (CYP2E1) expression was inhibited by the pretreatment of Cy-3-glu.	cyanidin-3-o-glucoside	185-193	glutathione S-transferase pi 1	Homo sapiens	34-39
23765758-1	2013	Glutathione S-transferase P1 (GSTP1) gene Ile105Val polymorphism has been suggested to be involved in the development of cancer.	ile105val	42-51	glutathione S-transferase pi 1	Homo sapiens	30-35
23292236-3	2013	As BU is mainly metabolized by glutathione S-transferase (GST), we investigated the relationship between GSTA1, GSTM1 and GSTP1 genotypes with first-dose BU PKs, and the relationship with HSCT outcomes in 69 children receiving myeloablative conditioning regimen.	Busulfan	3-5	glutathione S-transferase pi 1	Homo sapiens	122-127
23828841-11	2013	We hypothesize that the deletion of one GSTP1 allele (an isoform highly expressed in embryonic tissues), associated with specific environmental factors, such as tobacco and alcohol, could cause the esophageal atresia observed in our patient.	Alcohols	173-180	glutathione S-transferase pi 1	Homo sapiens	40-45
23597419-10	2013	Genetic variation in 24 ROS-related genes, including EGFR, CENPE, APEX1, and GSTP1, was associated with mRNA expression of 14 genes previously linked to fibrosis (P<=.005).	Reactive Oxygen Species	24-27	glutathione S-transferase pi 1	Homo sapiens	77-82
23572520-3	2013	We used transient kinetic methods to determine a minimal mechanism for spontaneous S-nitrosoglutathione (GSNO)-mediated transnitrosation of human glutathione transferase (GST) P1-1, a major detoxification enzyme and key regulator of cell proliferation.	S-Nitrosoglutathione	83-103	glutathione S-transferase pi 1	Homo sapiens	146-180
22441341-1	2013	INTRODUCTION: The primary aim of this study is to investigate the effect of change in the expression levels of survivin, glutathione-S-transferase P1 (GSTP1), and topoisomerase 2alpha (TOP2A) on the response to antracyclin-based and taxane-based neoadjuvant chemotherapy.	antracyclin	211-222	glutathione S-transferase pi 1	Homo sapiens	121-149
22441341-9	2013	Downregulation of GSTP1 after 4 cycles of anthracycline-based combination was independently associated with improved progression-free survival (P=0.01).	Anthracyclines	42-55	glutathione S-transferase pi 1	Homo sapiens	18-23
22441341-10	2013	CONCLUSIONS: Downregulation of GSTP1 is a significant predictor of pCR and improved progression-free survival during anthracycline-based and taxane-based neoadjuvant chemotherapy in patients with locally advanced breast cancer.	Anthracyclines	117-130	glutathione S-transferase pi 1	Homo sapiens	31-36
22441341-10	2013	CONCLUSIONS: Downregulation of GSTP1 is a significant predictor of pCR and improved progression-free survival during anthracycline-based and taxane-based neoadjuvant chemotherapy in patients with locally advanced breast cancer.	taxane	141-147	glutathione S-transferase pi 1	Homo sapiens	31-36
23604281-0	2013	Genetic polymorphisms of ERCC1-118, XRCC1-399 and GSTP1-105 are associated with the clinical outcome of gastric cancer patients receiving oxaliplatin-based adjuvant chemotherapy.	Oxaliplatin	138-149	glutathione S-transferase pi 1	Homo sapiens	50-55
23504587-0	2013	GSTP1 Ala114Val polymorphism and colorectal cancer risk: a meta-analysis.	ala114val	6-15	glutathione S-transferase pi 1	Homo sapiens	0-5
23504587-1	2013	Studies investigating the association between cytochrome glutathione S-transferase P1 (GSTP1) Ala114Val polymorphism and colorectal cancer (CRC) risk report conflicting results.	ala114val	94-103	glutathione S-transferase pi 1	Homo sapiens	57-85
23504587-1	2013	Studies investigating the association between cytochrome glutathione S-transferase P1 (GSTP1) Ala114Val polymorphism and colorectal cancer (CRC) risk report conflicting results.	ala114val	94-103	glutathione S-transferase pi 1	Homo sapiens	87-92
23504587-11	2013	This meta-analysis suggests that the GSTP1 Ala114Val polymorphism may not be associated with CRC risk, while the observed increase in risk of CRC may be due to small-study bias.	ala114val	43-52	glutathione S-transferase pi 1	Homo sapiens	37-42
23826324-0	2013	The GSTP1 105Val allele increases breast cancer risk and aggressiveness but enhances response to cyclophosphamide chemotherapy in North China.	Cyclophosphamide	97-113	glutathione S-transferase pi 1	Homo sapiens	4-9
23826324-2	2013	GSTP1 accounts for the majority of the GST family enzymatic activity, and the activity of GSTP1 enzyme can be altered by the presence of the Ile105Val polymorphism.	ile105val	141-150	glutathione S-transferase pi 1	Homo sapiens	0-5
23826324-2	2013	GSTP1 accounts for the majority of the GST family enzymatic activity, and the activity of GSTP1 enzyme can be altered by the presence of the Ile105Val polymorphism.	ile105val	141-150	glutathione S-transferase pi 1	Homo sapiens	90-95
23826324-5	2013	However, the patients with the GSTP1 105Val genotype had a better disease free survival after cyclophosphamide (CTX)-based chemotherapy than those with Ile/Ile (HR = 0.77, 95% CI: 0.45-0.91; P < 0.001).	Cyclophosphamide	94-110	glutathione S-transferase pi 1	Homo sapiens	31-36
23596995-2	2013	Active GSTP1-1 is a homodimer with cysteine residues close to the active site that can undergo oligomerization in response to stress, a process that affects enzyme activity and interactions with signaling and redox-active proteins.	Cysteine	35-43	glutathione S-transferase pi 1	Homo sapiens	7-14
23596995-4	2013	cyPG with dienone structure, which can bind to vicinal cysteines, induce an irreversible oligomerization of GSTP1-1.	dienone	10-17	glutathione S-transferase pi 1	Homo sapiens	108-115
23596995-4	2013	cyPG with dienone structure, which can bind to vicinal cysteines, induce an irreversible oligomerization of GSTP1-1.	vicinal cysteines	47-64	glutathione S-transferase pi 1	Homo sapiens	108-115
23572520-3	2013	We used transient kinetic methods to determine a minimal mechanism for spontaneous S-nitrosoglutathione (GSNO)-mediated transnitrosation of human glutathione transferase (GST) P1-1, a major detoxification enzyme and key regulator of cell proliferation.	S-Nitrosoglutathione	105-109	glutathione S-transferase pi 1	Homo sapiens	146-180
23572520-4	2013	Cys(47) of GSTP1-1 is S-nitrosated in two steps, with the chemical step limited by a pre-equilibrium between the open and closed conformations of helix alpha2 at the active site.	Cysteine	0-3	glutathione S-transferase pi 1	Homo sapiens	11-18
23572520-6	2013	Despite the presence of a GSNO binding site at the active site of GSTP1-1, isothermal titration calorimetry as well as nitrosation experiments using S-nitrosocysteine demonstrate that GSNO binding does not precede S-nitrosation of GSTP1-1.	S-Nitrosoglutathione	26-30	glutathione S-transferase pi 1	Homo sapiens	66-73
23376767-6	2013	By combining DNA damage in GA-treated lymphocytes and data on polymorphisms, associations between the induction of SCEs with GSTP1 (Ile105Val) and GSTA2 (Glu210Ala) genotypes are suggested.	glycidamide	27-29	glutathione S-transferase pi 1	Homo sapiens	125-130
23399543-7	2013	Furthermore, inhibition studies of native GST P1-1 using ethacrynic acid demonstrate that a ligand bound noncovalently to the wild-type enzyme also can elicit allosteric kinetic behavior.	Ethacrynic Acid	57-72	glutathione S-transferase pi 1	Homo sapiens	42-50
23254386-12	2013	In addition, since glutathione S-transferase-pi (GSTP1)             was re-expressed or its protein levels were increased after treatment with non-toxic             azacitidine doses and since GSTP1 can easily be measured in patient sera, the             monitoring of this protein may aide in the evaluation of therapy in future clinical             trials.	Glutathione	19-30	glutathione S-transferase pi 1	Homo sapiens	49-54
23530204-8	2013	Further evidence for a key role for this protein in MHR was obtained by showing that the GSTP1- and MDR-inhibiting pharmacophore 4-chloro-7-nitro-benzoxadiazole was also active toward AmGSTF1 and helped restore herbicide control in MHR black-grass.	4-chloro-7-nitro-benzoxadiazole	129-160	glutathione S-transferase pi 1	Homo sapiens	89-94
23530204-9	2013	These studies demonstrate a central role for specific GSTFs in MHR in weeds that has parallels with similar roles for unrelated GSTs in MDR in humans and shows their potential as targets for chemical intervention in resistant weed management.	gstfs	54-59	glutathione S-transferase pi 1	Homo sapiens	128-132
23299794-0	2013	XRCC1 and GSTP1 polymorphisms and prognosis of oxaliplatin-based chemotherapy in colorectal cancer: a meta-analysis.	Oxaliplatin	47-58	glutathione S-transferase pi 1	Homo sapiens	10-15
23299794-2	2013	The aim was to explore the influences of X-ray repair cross-complementing 1(XRCC1) and Glutathione S-transferase P1 (GSTP1) genetic variants on prognosis of oxaliplatin-based chemotherapy in colorectal cancer patients.	Oxaliplatin	157-168	glutathione S-transferase pi 1	Homo sapiens	87-115
23299794-2	2013	The aim was to explore the influences of X-ray repair cross-complementing 1(XRCC1) and Glutathione S-transferase P1 (GSTP1) genetic variants on prognosis of oxaliplatin-based chemotherapy in colorectal cancer patients.	Oxaliplatin	157-168	glutathione S-transferase pi 1	Homo sapiens	117-122
23426146-9	2013	The transient expression of GSTP1 specifically downregulated epidermal growth factor (EGF)-mediated tyrosine phosphorylation of Stat3, and subsequently suppressed the transcriptional activity of Stat3.	Tyrosine	100-108	glutathione S-transferase pi 1	Homo sapiens	28-33
23254386-12	2013	In addition, since glutathione S-transferase-pi (GSTP1)             was re-expressed or its protein levels were increased after treatment with non-toxic             azacitidine doses and since GSTP1 can easily be measured in patient sera, the             monitoring of this protein may aide in the evaluation of therapy in future clinical             trials.	Azacitidine	165-176	glutathione S-transferase pi 1	Homo sapiens	49-54
23053273-6	2013	In the group with tumor responses, we found a statistically significant downregulation of expression of ABCB1, ABCC1, ABCC2, ABCC5, ABCG1, ABCG2, GSTP1, and MVP genes following NAC in FAC and CAX-treated patients (67-93% of cases).	nac	177-180	glutathione S-transferase pi 1	Homo sapiens	146-151
23160801-13	2013	The results of this study suggest that the aberrations in one-carbon metabolism appear to induce altered gene expression of EC-SOD, GSTP1, and BNIP3, and thus contribute to the increased oxidative stress and increased susceptibility to CAD.	Carbon	62-68	glutathione S-transferase pi 1	Homo sapiens	132-137
23085367-6	2013	Xanthohumol, beside the induction of GSTs and HO-1, significantly elevated NQO1 expression in concert with p53 level in normal hepatocytes.	xanthohumol	0-11	glutathione S-transferase pi 1	Homo sapiens	37-41
23053273-6	2013	In the group with tumor responses, we found a statistically significant downregulation of expression of ABCB1, ABCC1, ABCC2, ABCC5, ABCG1, ABCG2, GSTP1, and MVP genes following NAC in FAC and CAX-treated patients (67-93% of cases).	CAX	192-195	glutathione S-transferase pi 1	Homo sapiens	146-151
23183361-4	2013	Here, we report on the inhibition effects of glutathione S-transferase P1-1 (GST P1-1) exerted by auranofin.	Auranofin	98-107	glutathione S-transferase pi 1	Homo sapiens	77-85
23183361-6	2013	Interestingly, the inhibition of GST P1-1 and its cysteine mutants by the gold(I) compound is essentially the same, suggesting that probably the cysteine residues are not so essential for enzyme inactivation in contrast to other reported inhibitors.	Cysteine	145-153	glutathione S-transferase pi 1	Homo sapiens	33-41
23640947-6	2013	Among genes associated with metabolism of the most commonly applied anaesthetics such as propofol and sevoflurane, the following ones can be mentioned: CYP2E1, CYP2B6, CYP2C9, GSTP1, UGT1A9, SULT1A1 and NQO1.	Propofol	89-97	glutathione S-transferase pi 1	Homo sapiens	176-181
23640947-6	2013	Among genes associated with metabolism of the most commonly applied anaesthetics such as propofol and sevoflurane, the following ones can be mentioned: CYP2E1, CYP2B6, CYP2C9, GSTP1, UGT1A9, SULT1A1 and NQO1.	Sevoflurane	102-113	glutathione S-transferase pi 1	Homo sapiens	176-181
23324581-0	2013	The association of seminal plasma antioxidant levels and sperm chromatin status with genetic variants of GSTM1 and GSTP1 (Ile105Val and Ala114Val) in infertile men with oligoasthenoteratozoospermia.	ile105val	122-131	glutathione S-transferase pi 1	Homo sapiens	115-120
21651746-5	2013	RESULTS: As expected, wild homozygotes for GSTP1 Ile105Val and EPHX1 slow/very slow phenotypes were associated with susceptibility (P=0.031) and severity (P=0.036) of COPD, respectively.	ile105val	49-58	glutathione S-transferase pi 1	Homo sapiens	43-48
23324581-1	2013	In this study we aimed to examine the effects of genetic variants of GSTM1 and GSTP1 (Ile105Val and Ala114Val) on GST activity, seminal oxidative stress and sperm chromatin status in infertile men with oligoasthenoteratozoospermia (OAT).	ile105val	86-95	glutathione S-transferase pi 1	Homo sapiens	79-84
23142420-1	2013	The dual-functioning antioxidant enzyme peroxiredoxin VI (Prdx6) detoxifies lipid peroxides particularly in biological membranes, and its peroxidase function is activated by glutathione S-transferase Pi (GSTP).	Lipid Peroxides	76-91	glutathione S-transferase pi 1	Homo sapiens	174-202
24058374-5	2013	Its 50% inhibition concentration (IC50) was 0.3  mu M, which was greater than a known GSTP1-1 inhibitor, ethacrynic acid (EA), using the established high-throughput screening model.	Ethacrynic Acid	105-120	glutathione S-transferase pi 1	Homo sapiens	86-93
24058374-5	2013	Its 50% inhibition concentration (IC50) was 0.3  mu M, which was greater than a known GSTP1-1 inhibitor, ethacrynic acid (EA), using the established high-throughput screening model.	Ethacrynic Acid	122-124	glutathione S-transferase pi 1	Homo sapiens	86-93
23569432-10	2013	GSTP1 expression level was correlated with plasma levels of MDA (P<0.01), XOD (P = 0.01) and GSH (P< 0.01), GST (P< 0.01).	Glutathione	96-99	glutathione S-transferase pi 1	Homo sapiens	0-5
23142420-1	2013	The dual-functioning antioxidant enzyme peroxiredoxin VI (Prdx6) detoxifies lipid peroxides particularly in biological membranes, and its peroxidase function is activated by glutathione S-transferase Pi (GSTP).	Lipid Peroxides	76-91	glutathione S-transferase pi 1	Homo sapiens	204-208
23142420-6	2013	Imaging of DPPP-labeled MCF-7 cells showed fluorescence localized in the plasma membrane, but intensity was substantially diminished in the GSTP1-1A- and GSTP1-1C-expressing cells.	1,3-bis(diphenylphosphino)propane	11-15	glutathione S-transferase pi 1	Homo sapiens	140-145
23142420-6	2013	Imaging of DPPP-labeled MCF-7 cells showed fluorescence localized in the plasma membrane, but intensity was substantially diminished in the GSTP1-1A- and GSTP1-1C-expressing cells.	1,3-bis(diphenylphosphino)propane	11-15	glutathione S-transferase pi 1	Homo sapiens	154-159
23142420-9	2013	The affinities for Prdx6 binding to GSH-loaded GSTP1-1"s either mirrored their observed peroxidase activities (using phospholipid hydroperoxide as a substrate), GSTP1-1A>GSTP1-1C (K(D)=51.0 vs 57.0 nM), or corresponded to inactivation, GSTP1-1B (GSTP1-1D) (K(D)=101.0 (94.0) nM).	Glutathione	36-39	glutathione S-transferase pi 1	Homo sapiens	47-54
23142420-9	2013	The affinities for Prdx6 binding to GSH-loaded GSTP1-1"s either mirrored their observed peroxidase activities (using phospholipid hydroperoxide as a substrate), GSTP1-1A>GSTP1-1C (K(D)=51.0 vs 57.0 nM), or corresponded to inactivation, GSTP1-1B (GSTP1-1D) (K(D)=101.0 (94.0) nM).	Glutathione	36-39	glutathione S-transferase pi 1	Homo sapiens	47-52
23142420-9	2013	The affinities for Prdx6 binding to GSH-loaded GSTP1-1"s either mirrored their observed peroxidase activities (using phospholipid hydroperoxide as a substrate), GSTP1-1A>GSTP1-1C (K(D)=51.0 vs 57.0 nM), or corresponded to inactivation, GSTP1-1B (GSTP1-1D) (K(D)=101.0 (94.0) nM).	Glutathione	36-39	glutathione S-transferase pi 1	Homo sapiens	161-166
23142420-9	2013	The affinities for Prdx6 binding to GSH-loaded GSTP1-1"s either mirrored their observed peroxidase activities (using phospholipid hydroperoxide as a substrate), GSTP1-1A>GSTP1-1C (K(D)=51.0 vs 57.0 nM), or corresponded to inactivation, GSTP1-1B (GSTP1-1D) (K(D)=101.0 (94.0) nM).	Glutathione	36-39	glutathione S-transferase pi 1	Homo sapiens	161-166
23142420-9	2013	The affinities for Prdx6 binding to GSH-loaded GSTP1-1"s either mirrored their observed peroxidase activities (using phospholipid hydroperoxide as a substrate), GSTP1-1A>GSTP1-1C (K(D)=51.0 vs 57.0 nM), or corresponded to inactivation, GSTP1-1B (GSTP1-1D) (K(D)=101.0 (94.0) nM).	Glutathione	36-39	glutathione S-transferase pi 1	Homo sapiens	161-166
23142420-9	2013	The affinities for Prdx6 binding to GSH-loaded GSTP1-1"s either mirrored their observed peroxidase activities (using phospholipid hydroperoxide as a substrate), GSTP1-1A>GSTP1-1C (K(D)=51.0 vs 57.0 nM), or corresponded to inactivation, GSTP1-1B (GSTP1-1D) (K(D)=101.0 (94.0) nM).	phospholipid hydroperoxide	117-143	glutathione S-transferase pi 1	Homo sapiens	47-54
23142420-9	2013	The affinities for Prdx6 binding to GSH-loaded GSTP1-1"s either mirrored their observed peroxidase activities (using phospholipid hydroperoxide as a substrate), GSTP1-1A>GSTP1-1C (K(D)=51.0 vs 57.0 nM), or corresponded to inactivation, GSTP1-1B (GSTP1-1D) (K(D)=101.0 (94.0) nM).	phospholipid hydroperoxide	117-143	glutathione S-transferase pi 1	Homo sapiens	47-52
23082001-0	2012	Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1.	Ethacrynic Acid	0-15	glutathione S-transferase pi 1	Homo sapiens	128-158
23774147-8	2013	CONCLUSION: The gene polymorphisms of GSTP1 G/G, XRCC1 A/A, and 5,10-MTHFR T/T have clinical value for predicting the response to the DCF regimen for advanced gastric cancer.	Pentostatin	134-137	glutathione S-transferase pi 1	Homo sapiens	38-43
21396852-0	2013	MiR-133a induces apoptosis through direct regulation of GSTP1 in bladder cancer cell lines.	mir-133a	0-8	glutathione S-transferase pi 1	Homo sapiens	56-61
21396852-9	2013	MiR-133a transfection repressed expression levels of mRNA and protein levels of GSTP1.	mir-133a	0-8	glutathione S-transferase pi 1	Homo sapiens	80-85
21396852-13	2013	CONCLUSION: Our data suggest that tumor suppressive miR-133a directly regulated oncogenic GSTP1 gene in BC, and that an anti-apoptotic effect mediated by GSTP1 is maintained by miR-133a down-regulation in human BC.	-133a	55-60	glutathione S-transferase pi 1	Homo sapiens	90-95
21396852-13	2013	CONCLUSION: Our data suggest that tumor suppressive miR-133a directly regulated oncogenic GSTP1 gene in BC, and that an anti-apoptotic effect mediated by GSTP1 is maintained by miR-133a down-regulation in human BC.	mir-133a	52-60	glutathione S-transferase pi 1	Homo sapiens	90-95
23035985-5	2012	LC-MS/MS analysis demonstrated efficient alkylation of Cys residues of proteins including glutathione-S-transferase-P1 (GST-P1) and Kelch-like ECH-associated protein 1 (Keap1).	Cysteine	55-58	glutathione S-transferase pi 1	Homo sapiens	90-118
23035985-5	2012	LC-MS/MS analysis demonstrated efficient alkylation of Cys residues of proteins including glutathione-S-transferase-P1 (GST-P1) and Kelch-like ECH-associated protein 1 (Keap1).	Cysteine	55-58	glutathione S-transferase pi 1	Homo sapiens	120-126
23082001-9	2012	Induction of apoptosis in leukemia and lymphoma cells expressing GSTP1-1 required high ethacrynic acid concentrations to be combined with ATO.	Ethacrynic Acid	87-102	glutathione S-transferase pi 1	Homo sapiens	65-72
22390478-0	2012	Response of glutathione S-transferase Pi (GSTP1) to neoadjuvant therapy in rectal adenocarcinoma.	Glutathione	12-23	glutathione S-transferase pi 1	Homo sapiens	42-47
23082001-9	2012	Induction of apoptosis in leukemia and lymphoma cells expressing GSTP1-1 required high ethacrynic acid concentrations to be combined with ATO.	Arsenic Trioxide	138-141	glutathione S-transferase pi 1	Homo sapiens	65-72
23082001-10	2012	Silencing of GSTP1 in leukemia cells sensitized them to ATO/EA-induced apoptosis.	Arsenic Trioxide	56-59	glutathione S-transferase pi 1	Homo sapiens	13-18
23082001-10	2012	Silencing of GSTP1 in leukemia cells sensitized them to ATO/EA-induced apoptosis.	Ethacrynic Acid	60-62	glutathione S-transferase pi 1	Homo sapiens	13-18
23082001-12	2012	CONCLUSION: B-cell lymphoma cells lacking GSTP1-1 are more sensitive than myeloid leukemia cells to ATO/EA-induced apoptosis.	Arsenic Trioxide	100-103	glutathione S-transferase pi 1	Homo sapiens	42-49
23082001-12	2012	CONCLUSION: B-cell lymphoma cells lacking GSTP1-1 are more sensitive than myeloid leukemia cells to ATO/EA-induced apoptosis.	Ethacrynic Acid	104-106	glutathione S-transferase pi 1	Homo sapiens	42-49
23072868-3	2012	Voltammetric measurements showed a strong decrease of the peak current intensity and an increase of the oxidation potential upon binding of ferrocene-glutathione conjugates to GST P1-1 showing that both conjugates can be used as dual electrochemical sensors for GST P1-1.	ferrocene	140-149	glutathione S-transferase pi 1	Homo sapiens	176-184
23072868-3	2012	Voltammetric measurements showed a strong decrease of the peak current intensity and an increase of the oxidation potential upon binding of ferrocene-glutathione conjugates to GST P1-1 showing that both conjugates can be used as dual electrochemical sensors for GST P1-1.	ferrocene	140-149	glutathione S-transferase pi 1	Homo sapiens	262-270
23072868-3	2012	Voltammetric measurements showed a strong decrease of the peak current intensity and an increase of the oxidation potential upon binding of ferrocene-glutathione conjugates to GST P1-1 showing that both conjugates can be used as dual electrochemical sensors for GST P1-1.	Glutathione	150-161	glutathione S-transferase pi 1	Homo sapiens	176-184
23072868-3	2012	Voltammetric measurements showed a strong decrease of the peak current intensity and an increase of the oxidation potential upon binding of ferrocene-glutathione conjugates to GST P1-1 showing that both conjugates can be used as dual electrochemical sensors for GST P1-1.	Glutathione	150-161	glutathione S-transferase pi 1	Homo sapiens	262-270
22497954-5	2012	METHODOLOGY: The methylation status of GSTP1 gene was analyzed by methylation specific PCR after bisulfate modification in H. pylori (+) (n=25) and (-) (n=25) intestinal metaplasia (IM) patients, GC (n=25) and control subjects (n=15) between September 2009 to November 2011.	hydrogen sulfate	97-106	glutathione S-transferase pi 1	Homo sapiens	39-44
23106910-6	2012	Ethanol upregulated GSTP1 and ALDH2 mRNAs, whereas cisplatin upregulated GSTP1 in HEK293 cells.	Ethanol	0-7	glutathione S-transferase pi 1	Homo sapiens	20-25
23106910-6	2012	Ethanol upregulated GSTP1 and ALDH2 mRNAs, whereas cisplatin upregulated GSTP1 in HEK293 cells.	Cisplatin	51-60	glutathione S-transferase pi 1	Homo sapiens	73-78
23106910-7	2012	SET-chromatin binding revealed SET interaction with ALDH2 and GSTP1 promoters, specifically via SET NAP domain; ethanol and cisplatin abolished SET binding.	Ethanol	112-119	glutathione S-transferase pi 1	Homo sapiens	62-67
23106910-7	2012	SET-chromatin binding revealed SET interaction with ALDH2 and GSTP1 promoters, specifically via SET NAP domain; ethanol and cisplatin abolished SET binding.	Cisplatin	124-133	glutathione S-transferase pi 1	Homo sapiens	62-67
22539223-7	2012	RESULTS: CG-5 and glucose deprivation upregulated the expression of DNA methylation-silenced tumor suppressor genes, including GADD45a, GADD45b, IGFBP3, LAMB3, BASP1, GPX3, and GSTP1, but also downregulated methylated tumor/invasion-promoting genes, including CD44, S100A4, and TACSTD2.	Glucose	18-25	glutathione S-transferase pi 1	Homo sapiens	177-182
22998212-6	2012	In total, 10 different peptide adducts were observed which result from modifications of Cys-47 and Cys-14 of hGST P1-1.	Cysteine	88-91	glutathione S-transferase pi 1	Homo sapiens	109-118
22998212-6	2012	In total, 10 different peptide adducts were observed which result from modifications of Cys-47 and Cys-14 of hGST P1-1.	Cysteine	99-102	glutathione S-transferase pi 1	Homo sapiens	109-118
22998212-12	2012	A corresponding GSH-conjugate with a similar mass increment was only observed if incubations of DF with P450 and GSH were supplemented by human GST P1-1.	Glutathione	16-19	glutathione S-transferase pi 1	Homo sapiens	144-152
23053942-11	2012	However, GSTP1 ile105 val gene polymorphism was not associated with HCC risk in Asian population.	Valine	22-25	glutathione S-transferase pi 1	Homo sapiens	9-14
22517484-3	2012	In this study, the authors investigated the clinical significance of the single nucleotide polymorphisms (SNPs) of 2 ROS metabolic process-related genes: superoxide dismutase 2 (SOD2) and glutathione S-transferase pi (GSTP1).	Reactive Oxygen Species	117-120	glutathione S-transferase pi 1	Homo sapiens	218-223
23330092-0	2012	Expression of genes of glutathione transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in tumor cells during the formation of drug resistance to cisplatin.	Cisplatin	144-153	glutathione S-transferase pi 1	Homo sapiens	56-63
22042007-0	2012	Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress.	procyanidin B2	0-14	glutathione S-transferase pi 1	Homo sapiens	46-74
22853296-4	2012	When adjusted for age, sex, smoking status, and alcohol use, the increased risk for ESCC was significantly associated with reduced expression of GSTP1, MTHFR, and NQO1, and GSTP1 mRNA showed a steady association with the risk for ESCC (OR=2.640) in the model of stepwise regression analysis.	Alcohols	48-55	glutathione S-transferase pi 1	Homo sapiens	145-150
22733800-7	2012	Differentiating cells showed significant induction in the expression of CYP1A1, 2B6, 2E1, 3A4, AHR, CAR, PXR, and GSTP1-1 when exposed to rifampin, a known universal inducer of CYPs.	Rifampin	138-146	glutathione S-transferase pi 1	Homo sapiens	114-121
23182048-1	2012	The aim of this prospective clinical study is to evaluate the relationship between changes in functional cardiac parameters following anthracycline therapy and carbonyl reductase 3 (CBR3p.V244M) and glutathione S transferase Pi (GSTP1p.I105V) polymorphisms.	Anthracyclines	134-147	glutathione S-transferase pi 1	Homo sapiens	229-235
22158036-2	2012	GSTP1 is a phase II detoxification enzyme and conjugates the tripeptide glutathione to endogenous metabolites and xenobiotics, thereby limiting the efficacy of antitumor chemotherapeutic treatments.	tripeptide K-26	61-71	glutathione S-transferase pi 1	Homo sapiens	0-5
22920299-6	2012	Unexpectedly, glutathione (GSH) exerted a negative effect on the affinity of GSTP1-1 for JNK1alpha2, suggesting that the intracellular levels of this thiol may allow a fine-tuning of the MAPK signaling pathway.	Glutathione	14-25	glutathione S-transferase pi 1	Homo sapiens	77-84
22920299-6	2012	Unexpectedly, glutathione (GSH) exerted a negative effect on the affinity of GSTP1-1 for JNK1alpha2, suggesting that the intracellular levels of this thiol may allow a fine-tuning of the MAPK signaling pathway.	Glutathione	27-30	glutathione S-transferase pi 1	Homo sapiens	77-84
22920299-6	2012	Unexpectedly, glutathione (GSH) exerted a negative effect on the affinity of GSTP1-1 for JNK1alpha2, suggesting that the intracellular levels of this thiol may allow a fine-tuning of the MAPK signaling pathway.	Sulfhydryl Compounds	150-155	glutathione S-transferase pi 1	Homo sapiens	77-84
22920299-7	2012	Moreover, we found that the adduct formed by GSH and the strong GSTP1-1 inhibitor NBDHEX abolishes the interaction between GSTP1-1 and JNK1alpha2.	Glutathione	45-48	glutathione S-transferase pi 1	Homo sapiens	64-71
22920299-7	2012	Moreover, we found that the adduct formed by GSH and the strong GSTP1-1 inhibitor NBDHEX abolishes the interaction between GSTP1-1 and JNK1alpha2.	Glutathione	45-48	glutathione S-transferase pi 1	Homo sapiens	123-130
22158036-2	2012	GSTP1 is a phase II detoxification enzyme and conjugates the tripeptide glutathione to endogenous metabolites and xenobiotics, thereby limiting the efficacy of antitumor chemotherapeutic treatments.	Glutathione	72-83	glutathione S-transferase pi 1	Homo sapiens	0-5
22158036-5	2012	Here we show that thiazolides induce a GSTP1-dependent and glutathione-enhanced cell death in colorectal tumor cell lines.	thiazolides	18-29	glutathione S-transferase pi 1	Homo sapiens	39-44
22158036-6	2012	Downregulation of GSTP1 reduced the apoptotic activity of thiazolides, whereas overexpression enhanced it.	thiazolides	58-69	glutathione S-transferase pi 1	Homo sapiens	18-23
22824824-10	2012	Six of them (DLC1, CHFR, ABCC5, PEG10, ERBB2, and GSTP1) were independently confirmed to contribute to taxol resistance by both methylation-specific PCR and quantitative real-time PCR.	Paclitaxel	103-108	glutathione S-transferase pi 1	Homo sapiens	50-55
23056073-8	2012	RESULTS: The frequency of the Val allele in exon 5 of the GSTP1 gene in patients with T2DM was higher than that observed in healthy controls (15.2% vs. 9.6%); the difference was considered statistically significant when compared to Ile allele carriers (p = 0.03).	Valine	30-33	glutathione S-transferase pi 1	Homo sapiens	58-63
22608530-8	2012	The method successfully revealed that RMs of both drugs adducted to Cys-47 of hGSTP and the mass shifts corresponded to modification by the N-acetyl-p-benzoquinone imine form of APAP and diquinone methide form of raloxifene, respectively.	N-acetyl-4-benzoquinoneimine	140-169	glutathione S-transferase pi 1	Homo sapiens	78-83
22751926-6	2012	Stimulation with FasL rapidly induced associations of Fas with ERp57 and glutathione S-transferase pi (GSTP), a protein disulfide isomerase and catalyst of S-glutathionylation, respectively, in the ER.	ammonium ferrous sulfate	17-20	glutathione S-transferase pi 1	Homo sapiens	73-101
22751926-6	2012	Stimulation with FasL rapidly induced associations of Fas with ERp57 and glutathione S-transferase pi (GSTP), a protein disulfide isomerase and catalyst of S-glutathionylation, respectively, in the ER.	ammonium ferrous sulfate	17-20	glutathione S-transferase pi 1	Homo sapiens	103-107
22751926-8	2012	Bleomycin-induced pulmonary fibrosis was accompanied by increased interactions between Fas-ERp57-GSTP1 and S-glutathionylation of Fas.	Bleomycin	0-9	glutathione S-transferase pi 1	Homo sapiens	97-102
22751926-8	2012	Bleomycin-induced pulmonary fibrosis was accompanied by increased interactions between Fas-ERp57-GSTP1 and S-glutathionylation of Fas.	ammonium ferrous sulfate	87-90	glutathione S-transferase pi 1	Homo sapiens	97-102
22749944-3	2012	Glutathione S-transferase P1 (GSTP1) has been reported to contribute to cisplatin resistance in many studies.	Cisplatin	72-81	glutathione S-transferase pi 1	Homo sapiens	0-28
22749944-3	2012	Glutathione S-transferase P1 (GSTP1) has been reported to contribute to cisplatin resistance in many studies.	Cisplatin	72-81	glutathione S-transferase pi 1	Homo sapiens	30-35
22749944-7	2012	This study aims to determine whether deregulated miRNAs can sensitize human lung adenocarcinoma cells to cisplatin by targeting GSTP1.	Cisplatin	105-114	glutathione S-transferase pi 1	Homo sapiens	128-133
22749944-11	2012	In conclusion, our data demonstrated that miR-513a-3p can sensitize human lung adenocarcinoma cells to cisplatin by targeting GSTP1.	Cisplatin	103-112	glutathione S-transferase pi 1	Homo sapiens	126-131
22608530-4	2012	The technique was illustrated by the trapping of RMs of acetaminophen (APAP) and raloxifene with human glutathione S-transferase pi (hGSTP) as a model target protein.	Acetaminophen	56-69	glutathione S-transferase pi 1	Homo sapiens	133-138
22608530-4	2012	The technique was illustrated by the trapping of RMs of acetaminophen (APAP) and raloxifene with human glutathione S-transferase pi (hGSTP) as a model target protein.	Acetaminophen	71-75	glutathione S-transferase pi 1	Homo sapiens	133-138
22608530-8	2012	The method successfully revealed that RMs of both drugs adducted to Cys-47 of hGSTP and the mass shifts corresponded to modification by the N-acetyl-p-benzoquinone imine form of APAP and diquinone methide form of raloxifene, respectively.	Acetaminophen	178-182	glutathione S-transferase pi 1	Homo sapiens	78-83
22608530-4	2012	The technique was illustrated by the trapping of RMs of acetaminophen (APAP) and raloxifene with human glutathione S-transferase pi (hGSTP) as a model target protein.	Raloxifene Hydrochloride	81-91	glutathione S-transferase pi 1	Homo sapiens	133-138
22608530-8	2012	The method successfully revealed that RMs of both drugs adducted to Cys-47 of hGSTP and the mass shifts corresponded to modification by the N-acetyl-p-benzoquinone imine form of APAP and diquinone methide form of raloxifene, respectively.	diquinone	187-196	glutathione S-transferase pi 1	Homo sapiens	78-83
22608530-8	2012	The method successfully revealed that RMs of both drugs adducted to Cys-47 of hGSTP and the mass shifts corresponded to modification by the N-acetyl-p-benzoquinone imine form of APAP and diquinone methide form of raloxifene, respectively.	Cysteine	68-71	glutathione S-transferase pi 1	Homo sapiens	78-83
22608530-8	2012	The method successfully revealed that RMs of both drugs adducted to Cys-47 of hGSTP and the mass shifts corresponded to modification by the N-acetyl-p-benzoquinone imine form of APAP and diquinone methide form of raloxifene, respectively.	Raloxifene Hydrochloride	213-223	glutathione S-transferase pi 1	Homo sapiens	78-83
22052985-4	2012	Specifically, GSTM1 and GSTT1 genes are polymorphically deleted, the polymorphism GSTP1 c.313A>G (rs1695) determines the amino acid substitution Ile105Val, where the Val-containing enzyme has reduced activity.	Valine	154-157	glutathione S-transferase pi 1	Homo sapiens	82-87
22740430-3	2012	To identify and characterize the potential inhibitory mechanisms of GST P1-1 induced by isothiocyanate conjugates, we studied the binding of GST P1-1 and some cysteine mutants to the BITC-SG conjugate as well as to the synthetic S-(N-benzylcarbamoylmethyl)glutathione conjugate (BC-SG).	isothiocyanic acid	88-102	glutathione S-transferase pi 1	Homo sapiens	68-76
22740430-12	2012	Thus, we conclude that the presence of the sulfur atom from the isothiocyanate moiety in BITC-SG is crucial for its irreversible inhibition of GST P1-1.	Sulfur	43-49	glutathione S-transferase pi 1	Homo sapiens	143-151
22740430-12	2012	Thus, we conclude that the presence of the sulfur atom from the isothiocyanate moiety in BITC-SG is crucial for its irreversible inhibition of GST P1-1.	isothiocyanic acid	64-78	glutathione S-transferase pi 1	Homo sapiens	143-151
22580340-4	2012	Chromatin immunoprecipitation assay demonstrated that CDX2 binds to the GST P1 promoter containing the putative consensus CDX-binding element, TTTAC, located at -247 upstream from the established site for transcription initiation.	Cefadroxil	54-57	glutathione S-transferase pi 1	Homo sapiens	72-78
22580340-5	2012	Using the dsDNA pull-down assay, it was revealed that CDX2 recognized and bound to the putative consensus CDX-binding element within the human GST P1 promoter region and that the amount of the CDX2 bound to the putative consensus CDX-binding element increased during Caco-2 cell differentiation.	Cefadroxil	54-57	glutathione S-transferase pi 1	Homo sapiens	143-149
22580340-5	2012	Using the dsDNA pull-down assay, it was revealed that CDX2 recognized and bound to the putative consensus CDX-binding element within the human GST P1 promoter region and that the amount of the CDX2 bound to the putative consensus CDX-binding element increased during Caco-2 cell differentiation.	Cefadroxil	106-109	glutathione S-transferase pi 1	Homo sapiens	143-149
22580340-6	2012	Furthermore, we demonstrated that CDX2 formed the transcriptional complex with Sp1 and bound to the putative consensus CDX-binding element within the human GST P1 promoter region.	Cefadroxil	34-37	glutathione S-transferase pi 1	Homo sapiens	156-162
22052985-0	2012	Glutathione S-transferase P1 c.313A > G polymorphism could be useful in the prediction of doxorubicin response in breast cancer patients.	Doxorubicin	93-104	glutathione S-transferase pi 1	Homo sapiens	0-28
22052985-4	2012	Specifically, GSTM1 and GSTT1 genes are polymorphically deleted, the polymorphism GSTP1 c.313A>G (rs1695) determines the amino acid substitution Ile105Val, where the Val-containing enzyme has reduced activity.	ile105val	148-157	glutathione S-transferase pi 1	Homo sapiens	82-87
22052985-10	2012	RESULTS: In multivariate analysis, patients homozygous GG for GSTP1 c.313A>G SNP had a lower risk of chemoresistance when treated with doxorubicin (odds ratio 0.106; confidence interval 0.012-0.898; P=0.040).	Doxorubicin	138-149	glutathione S-transferase pi 1	Homo sapiens	62-67
22052985-13	2012	CONCLUSIONS: GSTP1 may constitute another tool contributing to individualized anthracycline-based therapy.	Anthracyclines	78-91	glutathione S-transferase pi 1	Homo sapiens	13-18
21840698-11	2012	GSTP1 expression tended to result in an increase by the fs aleurone in both cell types, whereas the probiotics could not additionally increase the effect.	phenylalanylserine	56-58	glutathione S-transferase pi 1	Homo sapiens	0-5
22424617-11	2012	The GSTP1 wild-type genotype in the presence of medium-high blood levels of PCB153, total PCBs, or of high levels of PCB180 significantly increased the risk of endometriosis, suggesting a multiplicative interaction.	2,4,5,2',4',5'-hexachlorobiphenyl	76-82	glutathione S-transferase pi 1	Homo sapiens	4-9
22425687-0	2012	Perfluorooctanoic acid induces gene promoter hypermethylation of glutathione-S-transferase Pi in human liver L02 cells.	perfluorooctanoic acid	0-22	glutathione S-transferase pi 1	Homo sapiens	65-93
22425687-7	2012	Global DNA methylation levels were determined by LC/ESI-MS, glutathione-S-transferase Pi (GSTP) gene promoter DNA methylation was investigated by methylation-specific polymerase chain reaction (PCR) with bisulfite sequencing, and consequent mRNA expression levels were measured with quantitative real-time reverse transcriptase PCR.	hydrogen sulfite	204-213	glutathione S-transferase pi 1	Homo sapiens	90-94
22251241-1	2012	BACKGROUND: Glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 are multifunctional enzymes involved in the detoxification of a wide range of reactive oxygen species produced during melanin synthesis and oxidative stress processes.	Reactive Oxygen Species	147-170	glutathione S-transferase pi 1	Homo sapiens	63-68
22251241-1	2012	BACKGROUND: Glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 are multifunctional enzymes involved in the detoxification of a wide range of reactive oxygen species produced during melanin synthesis and oxidative stress processes.	Melanins	187-194	glutathione S-transferase pi 1	Homo sapiens	63-68
22031394-8	2012	Patients who carried the homozygous mutant glutathione S-transferase pi 1(GSTP1) GG genotype were at considerable risk for severe platinum-associated polyneuropathy (18% vs 3% in wild-type vs heterozygous mutant patients, respectively; P = .01).	Platinum	130-138	glutathione S-transferase pi 1	Homo sapiens	43-73
22031394-8	2012	Patients who carried the homozygous mutant glutathione S-transferase pi 1(GSTP1) GG genotype were at considerable risk for severe platinum-associated polyneuropathy (18% vs 3% in wild-type vs heterozygous mutant patients, respectively; P = .01).	Platinum	130-138	glutathione S-transferase pi 1	Homo sapiens	74-79
22031394-9	2012	CONCLUSIONS: To the authors" knowledge, this is the first prospective study to date in patients with advanced NSCLC describing predictive germline polymorphisms not only for the clinical activity of PG chemotherapy (ERCC1, XPD10) but also for its toxicity (GSTP1, RECQ1, CDA).	pg	199-201	glutathione S-transferase pi 1	Homo sapiens	257-262
22572643-0	2012	Variants in the genes encoding TNF-alpha, IL-10, and GSTP1 influence the effect of alpha-tocopherol on inflammatory cell responses in healthy men.	alpha-Tocopherol	83-99	glutathione S-transferase pi 1	Homo sapiens	53-58
22572643-8	2012	The ability of alpha-tocopherol to affect IL-6 production was influenced by the GSTP1 313 polymorphism (P = 0.019).	alpha-Tocopherol	15-31	glutathione S-transferase pi 1	Homo sapiens	80-85
22298307-6	2012	The results showed that GSTP1 knockdown significantly increased the efficiency of benzo(a)pyrene-induced 16HBE cell transformation.	Benzo(a)pyrene	82-96	glutathione S-transferase pi 1	Homo sapiens	24-29
22320227-1	2012	The purpose of the present study was to investigate the association of glutathione S-transferase P1 (GSTP1) expression with resistance to neoadjuvant paclitaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (P-FEC) in human breast cancers.	Paclitaxel	150-160	glutathione S-transferase pi 1	Homo sapiens	71-99
22320227-1	2012	The purpose of the present study was to investigate the association of glutathione S-transferase P1 (GSTP1) expression with resistance to neoadjuvant paclitaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (P-FEC) in human breast cancers.	Paclitaxel	150-160	glutathione S-transferase pi 1	Homo sapiens	101-106
22320227-1	2012	The purpose of the present study was to investigate the association of glutathione S-transferase P1 (GSTP1) expression with resistance to neoadjuvant paclitaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (P-FEC) in human breast cancers.	Fluorouracil	173-187	glutathione S-transferase pi 1	Homo sapiens	71-99
22320227-1	2012	The purpose of the present study was to investigate the association of glutathione S-transferase P1 (GSTP1) expression with resistance to neoadjuvant paclitaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (P-FEC) in human breast cancers.	Epirubicin	188-198	glutathione S-transferase pi 1	Homo sapiens	71-99
22320227-1	2012	The purpose of the present study was to investigate the association of glutathione S-transferase P1 (GSTP1) expression with resistance to neoadjuvant paclitaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (P-FEC) in human breast cancers.	Cyclophosphamide	199-215	glutathione S-transferase pi 1	Homo sapiens	71-99
22424617-11	2012	The GSTP1 wild-type genotype in the presence of medium-high blood levels of PCB153, total PCBs, or of high levels of PCB180 significantly increased the risk of endometriosis, suggesting a multiplicative interaction.	Polychlorinated Biphenyls	90-94	glutathione S-transferase pi 1	Homo sapiens	4-9
22424617-11	2012	The GSTP1 wild-type genotype in the presence of medium-high blood levels of PCB153, total PCBs, or of high levels of PCB180 significantly increased the risk of endometriosis, suggesting a multiplicative interaction.	PCB 180	117-123	glutathione S-transferase pi 1	Homo sapiens	4-9
22424617-13	2012	However, a gene-environment interaction was observed for GSTP1(Ile/Ile) and GSTM1 null genotypes, modulating the effect of PCB153, PCB180, and of total PCBs on disease risk.	2,4,5,2',4',5'-hexachlorobiphenyl	123-129	glutathione S-transferase pi 1	Homo sapiens	57-62
22424617-13	2012	However, a gene-environment interaction was observed for GSTP1(Ile/Ile) and GSTM1 null genotypes, modulating the effect of PCB153, PCB180, and of total PCBs on disease risk.	PCB 180	131-137	glutathione S-transferase pi 1	Homo sapiens	57-62
22424617-13	2012	However, a gene-environment interaction was observed for GSTP1(Ile/Ile) and GSTM1 null genotypes, modulating the effect of PCB153, PCB180, and of total PCBs on disease risk.	Polychlorinated Biphenyls	152-156	glutathione S-transferase pi 1	Homo sapiens	57-62
21887679-1	2012	BACKGROUND: Ezatiostat is a glutathione analog prodrug glutathione S-transferase P1-1 (GSTP1-1) inhibitor.	gamma-Glu-S-BzCys-PhGly diethyl ester	12-22	glutathione S-transferase pi 1	Homo sapiens	87-94
22306368-6	2012	We found evidence of genotype-arsenic interactions in the high exposure group; GSTP1 Ile105Val homozygous individuals had an odds ratio (OR) of 5.4 [95% confidence interval (CI): 1.5-20.2; P for interaction=0.03] and AQP3 Phe130Phe carriers had an OR=2.2 (95% CI: 0.8-6.1; P for interaction=0.10).	Arsenic	30-37	glutathione S-transferase pi 1	Homo sapiens	79-84
22161138-13	2012	Although with modest limitations and biases, this metaanalysis suggests that EPHX1 Tyr113His and His139Arg, GSTT1, GSTM1, GSTP1 Ile105Val and Ala114Val polymorphisms may be not risk factors for CRA development, while Ser allele of NQO1 Ser187 Pro may be a modest risk factor for CRA development, and may be used with other genetic markers for screening CRA in the future.	Serine	217-220	glutathione S-transferase pi 1	Homo sapiens	122-127
22286029-4	2012	We have explored carotenoid-binding interactions of five proteins: human serum albumin (HSA), beta-lactoglobulin (LG), steroidogenic acute regulatory domain proteins (StARD1, StARD3) and glutathione S- transferase Pi isoform (GSTP1).	Carotenoids	17-27	glutathione S-transferase pi 1	Homo sapiens	226-231
21973220-2	2012	Excess ROS (reactive oxygen species) contribute to endothelial damage under hypobaric hypoxia, hence the oxidative-stress-related genes CYBA (cytochrome b-245 alpha polypeptide) and GSTP1 (glutathione transferase Pi 1) are potential candidate genes for HAPE.	Reactive Oxygen Species	7-10	glutathione S-transferase pi 1	Homo sapiens	182-187
21973220-2	2012	Excess ROS (reactive oxygen species) contribute to endothelial damage under hypobaric hypoxia, hence the oxidative-stress-related genes CYBA (cytochrome b-245 alpha polypeptide) and GSTP1 (glutathione transferase Pi 1) are potential candidate genes for HAPE.	Reactive Oxygen Species	12-35	glutathione S-transferase pi 1	Homo sapiens	182-187
21973220-8	2012	8-Iso-PGF2alpha levels were significantly higher in HAPE-p and in HLs than in HAPE-r (P=2.2x10(-16) and 1.2x10(-14) respectively) and the expression of CYBA and GSTP1 varied differentially (P<0.05).	8-epi-prostaglandin F2alpha	0-15	glutathione S-transferase pi 1	Homo sapiens	161-166
22142694-0	2012	Galangin induces apoptosis in gastric cancer cells via regulation of ubiquitin carboxy-terminal hydrolase isozyme L1 and glutathione S-transferase P.	galangin	0-8	glutathione S-transferase pi 1	Homo sapiens	121-148
22142694-11	2012	Our results suggest that Uch-L1 and GSTP be involved in galangin-induced apoptosis in human gastric cancer SNU-484 cells.	galangin	56-64	glutathione S-transferase pi 1	Homo sapiens	36-40
22385947-6	2012	At a cutoff of >=231 ng/mL, GSTP1 identified HF patients with EF <=22% with 81% sensitivity and 83% specificity, and at a cutoff of >=655 pg/mL, proBNP identified the same patient group with 84% sensitivity and 22% specificity.	probnp	154-160	glutathione S-transferase pi 1	Homo sapiens	31-36
22376260-4	2012	Promoter methylation of two prostate cancer-associated genes, GSTP1 and RARB2, was assessed by methylation-specific PCR of bisulfite-converted cfDNA.	hydrogen sulfite	123-132	glutathione S-transferase pi 1	Homo sapiens	62-67
22221655-2	2012	The enzyme activity of the member of GSTs, GSTP1, depends on gene polymorphisms such as: Ala114Val and Ile105Val.	ala114val	89-98	glutathione S-transferase pi 1	Homo sapiens	37-41
22221655-2	2012	The enzyme activity of the member of GSTs, GSTP1, depends on gene polymorphisms such as: Ala114Val and Ile105Val.	ala114val	89-98	glutathione S-transferase pi 1	Homo sapiens	43-48
22221655-2	2012	The enzyme activity of the member of GSTs, GSTP1, depends on gene polymorphisms such as: Ala114Val and Ile105Val.	ile105val	103-112	glutathione S-transferase pi 1	Homo sapiens	37-41
22221655-2	2012	The enzyme activity of the member of GSTs, GSTP1, depends on gene polymorphisms such as: Ala114Val and Ile105Val.	ile105val	103-112	glutathione S-transferase pi 1	Homo sapiens	43-48
22221655-5	2012	MAIN OUTCOME MEASURES: Ala114Val and Ile105Val polymorphisms genotypes of GSTP1 gene, bone mineral density (BMD) values of total hip (_th), femoral neck (_fn) and lumbar spine (_ls), plasma osteocalcin (OC), serum bone alkaline phosphatase (BALP), free soluble RANKL and serum osteoprotegerin (sOPG) concentrations were determined.	ile105val	37-46	glutathione S-transferase pi 1	Homo sapiens	74-79
22084240-9	2012	Recently, glutathione S-transferase P1-1 (GST P1-1) was shown to bind DNICs as dinitrosyl-diglutathionyl iron complexes.	dinitrosyl diglutathionyl iron	79-109	glutathione S-transferase pi 1	Homo sapiens	42-50
22084240-11	2012	Cells transfected with GSTP1 (but not GSTA1 or GSTM1) significantly decreased NO-mediated 59Fe release from cells.	Iron-59	90-94	glutathione S-transferase pi 1	Homo sapiens	23-28
22084240-13	2012	Notably, 59Fe accumulated in cells within GST P1-1-containing fractions, indicating an alteration in intracellular 59Fe distribution.	Iron-59	9-13	glutathione S-transferase pi 1	Homo sapiens	42-50
22084240-13	2012	Notably, 59Fe accumulated in cells within GST P1-1-containing fractions, indicating an alteration in intracellular 59Fe distribution.	Iron-59	115-119	glutathione S-transferase pi 1	Homo sapiens	42-50
22799388-1	2012	In the present case control study mRNA expression of the GSTP1 gene, encoding a phase II enzyme that detoxifies via glutathione conjugation, was investigated using semiquantitative PCR followed by SSCP for 49 confirmed head and neck (HN) cancer and 49 control samples.	Glutathione	116-127	glutathione S-transferase pi 1	Homo sapiens	57-62
22994779-2	2012	We assessed whether single nucleotide polymorphisms (SNPs) in GSTP1, ERCC1 Asn118Asn and ERCC2 Lys751Gln might predict the overall survival in patients receiving oxaliplatin-based chemotherapy in a Chinese population.	Oxaliplatin	162-173	glutathione S-transferase pi 1	Homo sapiens	62-67
22994779-8	2012	CONCLUSION: GSTP1, GSTP1, ERCC1 Asn118Asn and ERCC2 Lys751Gln genotyping might facilitate tailored oxaliplatin-based chemotherapy for colorectal cancer patients.	Oxaliplatin	99-110	glutathione S-transferase pi 1	Homo sapiens	12-17
23167352-8	2012	CONCLUSION: This study indicated that GSTP1 Ile105Val, XRCC1 Arg194Trp and XRCC1Arg399Gln genes have a role in modifying the effect of platinum-based chemotherapy for NSCLC patients in a Chinese population.	Platinum	135-143	glutathione S-transferase pi 1	Homo sapiens	38-43
22175791-0	2012	The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients.	Glutathione	16-27	glutathione S-transferase pi 1	Homo sapiens	66-71
22175791-0	2012	The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients.	Acetaminophen	75-88	glutathione S-transferase pi 1	Homo sapiens	66-71
21711092-2	2012	The substitution of isoleucine to valine residue at position 105 of the GSTP1 protein results in decreased enzyme activity and hence less capability of effective detoxification.	Isoleucine	20-30	glutathione S-transferase pi 1	Homo sapiens	72-77
21711092-2	2012	The substitution of isoleucine to valine residue at position 105 of the GSTP1 protein results in decreased enzyme activity and hence less capability of effective detoxification.	Valine	34-40	glutathione S-transferase pi 1	Homo sapiens	72-77
21940361-0	2012	Predictive value of expression of ERCC 1 and GST-p for 5-fluorouracil/oxaliplatin chemotherapy in advanced colorectal cancer.	Fluorouracil	55-69	glutathione S-transferase pi 1	Homo sapiens	45-50
21940361-0	2012	Predictive value of expression of ERCC 1 and GST-p for 5-fluorouracil/oxaliplatin chemotherapy in advanced colorectal cancer.	Oxaliplatin	70-81	glutathione S-transferase pi 1	Homo sapiens	45-50
21940361-9	2012	CONCLUSIONS: Immunohistochemical studies for ERCC-1 and GST-p may be useful in prediction of the response to 5-fluorouracil/oxaliplatin chemotherapy in advanced colorectal cancer patients.	Fluorouracil	109-123	glutathione S-transferase pi 1	Homo sapiens	56-61
21940361-9	2012	CONCLUSIONS: Immunohistochemical studies for ERCC-1 and GST-p may be useful in prediction of the response to 5-fluorouracil/oxaliplatin chemotherapy in advanced colorectal cancer patients.	Oxaliplatin	124-135	glutathione S-transferase pi 1	Homo sapiens	56-61
22567180-3	2012	METHODS: A novel oligonucleotide microarray was developed to genotype 13 variations (DPYD*2, DPYD*5, DPYD*9, TYMS 6 bp Ins/Del, UGT1A1*6, UGT1A1*27, UGT1A1*28, GSTP1 Ile105Val, XRCC1 Arg399Gln, MTHFR C677T, MDR1 C3435T/A, MDR1 G2677A/T and ERCC1 C118T).	Oligonucleotides	17-32	glutathione S-transferase pi 1	Homo sapiens	160-165
22089643-7	2012	Furthermore, transient transfection of miR-133a, repressed ARPC5 and GSTP1 mRNA and protein levels.	mir-133a	39-47	glutathione S-transferase pi 1	Homo sapiens	69-74
22291700-3	2012	The objective of this study was to assess the association of GSTs (GSTT1, GSTM1, and GSTP1 Val105Ile) polymorphisms with blood Cd concentrations in a nonoccupationally exposed population.	Cadmium	127-129	glutathione S-transferase pi 1	Homo sapiens	85-90
22291700-6	2012	Blood Cd concentrations in subjects carrying GSTP1 Val/Val genotype were significantly higher than those with Ile/Ile and Ile/Val genotypes.	Cadmium	6-8	glutathione S-transferase pi 1	Homo sapiens	45-50
22291700-8	2012	GSTP1/GSTT1 and GSTP1/GSTM1 combinations showed significantly associated with increase in blood Cd levels.	Cadmium	96-98	glutathione S-transferase pi 1	Homo sapiens	0-5
22291700-8	2012	GSTP1/GSTT1 and GSTP1/GSTM1 combinations showed significantly associated with increase in blood Cd levels.	Cadmium	96-98	glutathione S-transferase pi 1	Homo sapiens	16-21
22291700-9	2012	This study indicated that polymorphisms of GSTP1 combined with GSTT1 and/or GSTM1 deletion are likely to influence on individual susceptibility to cadmium toxicity.	Cadmium	147-154	glutathione S-transferase pi 1	Homo sapiens	43-48
22028001-0	2012	Individual variations in arsenic metabolism in Vietnamese: the association with arsenic exposure and GSTP1 genetic polymorphism.	Arsenic	25-32	glutathione S-transferase pi 1	Homo sapiens	101-106
22028001-1	2012	We investigated the association of As exposure and genetic polymorphism in glutathione S-transferase pi1 (GSTP1) with As metabolism in 190 local residents from the As contaminated groundwater areas in the Red River Delta, Vietnam.	Arsenic	118-120	glutathione S-transferase pi 1	Homo sapiens	75-104
22028001-1	2012	We investigated the association of As exposure and genetic polymorphism in glutathione S-transferase pi1 (GSTP1) with As metabolism in 190 local residents from the As contaminated groundwater areas in the Red River Delta, Vietnam.	Arsenic	118-120	glutathione S-transferase pi 1	Homo sapiens	106-111
22028001-5	2012	Concentration and proportion of As(III) were high in the wild type of GSTP1 Ile105Val compared with the hetero type, and these trends were more pronounced in the higher As exposure group (>56 mug l(-1) creatinine in urine), but not in the lower exposure group.	as(iii)	32-39	glutathione S-transferase pi 1	Homo sapiens	70-75
22028001-6	2012	In the high As exposure group, As(III)/As(V) ratios in the urine of wild type of GSTP1 Ile105Val were significantly higher than those of the hetero type, while the opposite trend was observed for M/I.	Arsenic	12-14	glutathione S-transferase pi 1	Homo sapiens	81-86
22068640-0	2012	Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines.	Cisplatin	67-76	glutathione S-transferase pi 1	Homo sapiens	10-17
22068640-2	2012	Despite the different enzyme"s content, inhibition of GSTP1-1 by 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) causes the activation of c-Jun N-terminal kinase (JNK) and apoptosis in both cell lines.	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	65-112	glutathione S-transferase pi 1	Homo sapiens	54-61
22068640-2	2012	Despite the different enzyme"s content, inhibition of GSTP1-1 by 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) causes the activation of c-Jun N-terminal kinase (JNK) and apoptosis in both cell lines.	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	114-120	glutathione S-transferase pi 1	Homo sapiens	54-61
22262835-10	2012	The generation of dinitrosyl-dithiol-iron complexes acts as a common currency for NO transport and storage by MRP1 and GST P1-1, respectively.	dinitrosyl-dithiol	18-36	glutathione S-transferase pi 1	Homo sapiens	119-127
22262835-10	2012	The generation of dinitrosyl-dithiol-iron complexes acts as a common currency for NO transport and storage by MRP1 and GST P1-1, respectively.	Iron	37-41	glutathione S-transferase pi 1	Homo sapiens	119-127
22310978-9	2012	CONCLUSIONS: These results suggest that polymorphisms in GSTP1 and MDR1 may help to predict clinical response and DFS of anthracycline-based chemotherapy, and a polygenic pathway approach should provide more useful information.	Anthracyclines	121-134	glutathione S-transferase pi 1	Homo sapiens	57-62
21887679-1	2012	BACKGROUND: Ezatiostat is a glutathione analog prodrug glutathione S-transferase P1-1 (GSTP1-1) inhibitor.	Glutathione	28-39	glutathione S-transferase pi 1	Homo sapiens	87-94
21887679-13	2012	CONCLUSIONS: Ezatiostat is the first GSTP1-1 inhibitor shown to cause clinically significant and sustained reduction in RBC transfusions, transfusion independence, and multilineage responses in MDS patients.	gamma-Glu-S-BzCys-PhGly diethyl ester	13-23	glutathione S-transferase pi 1	Homo sapiens	37-44
21890734-7	2011	The mutant containing Phe87 showed high activity and high selectivity for the bioactivation pathway and was used for the large-scale production of GST-dependent GSH conjugates by incubation in the presence of recombinant human GST P1-1.	Glutathione	161-164	glutathione S-transferase pi 1	Homo sapiens	227-235
23077566-0	2012	Interaction between GSTP1 Val allele and H. pylori infection, smoking and alcohol consumption and risk of gastric cancer among the Chinese population.	Alcohols	74-81	glutathione S-transferase pi 1	Homo sapiens	20-25
23077566-10	2012	The GSTP1 Val allele shows an interaction with smoking, alcohol consumption, and especially H. pylori infection for increasing the risk of gastric cancer.	Alcohols	56-63	glutathione S-transferase pi 1	Homo sapiens	4-9
23144854-6	2012	RESULTS: The results of this meta-analysis showed that the GSTP1 Ile105Val polymorphism was not significantly associated with risk of HNC in the overall study population (pooled OR 1.00, 95% CI 0.92-1.09) or in subgroup analyses stratified by ethnicity, sample size, tumor site or publication year.	ile105val	65-74	glutathione S-transferase pi 1	Homo sapiens	59-64
22536438-4	2012	To test this hypothesis, we compared the methylation status of the GSTP1 promoter region of the DNA isolated from HCC, cirrhosis, hepatitis, and normal liver tissues by bisulfite-PCR sequencing.	hydrogen sulfite	169-178	glutathione S-transferase pi 1	Homo sapiens	67-72
22180037-2	2011	One of the common functional polymorphisms of GSTP1 is A G at nucleotide  313, which results in an amino acid substitution (Ile105Val) at the substrate  binding site of GSTP1 and reduces catalytic activity of GSTP1.	ile105val	124-133	glutathione S-transferase pi 1	Homo sapiens	46-51
22180037-2	2011	One of the common functional polymorphisms of GSTP1 is A G at nucleotide  313, which results in an amino acid substitution (Ile105Val) at the substrate  binding site of GSTP1 and reduces catalytic activity of GSTP1.	ile105val	124-133	glutathione S-transferase pi 1	Homo sapiens	169-174
22180037-2	2011	One of the common functional polymorphisms of GSTP1 is A G at nucleotide  313, which results in an amino acid substitution (Ile105Val) at the substrate  binding site of GSTP1 and reduces catalytic activity of GSTP1.	ile105val	124-133	glutathione S-transferase pi 1	Homo sapiens	169-174
21834791-4	2011	Formation of the potential NO donor dinitrosyl-diglutathionyl-iron complex, bound to GSTP1-1 (glutathione transferase P1-1), was observed in both MCF7/Dx cells and drug-sensitive MCF7 cells to a similar extent.	dinitrosyl diglutathionyl iron	36-66	glutathione S-transferase pi 1	Homo sapiens	85-92
21834791-6	2011	These results suggest that the increased cytotoxic effect of combined doxorubicin and GSNO treatment involves the glutathionylation of histones through a mechanism that requires high glutathione levels and increased expression of GSTP1-1.	Doxorubicin	70-81	glutathione S-transferase pi 1	Homo sapiens	230-237
21834791-6	2011	These results suggest that the increased cytotoxic effect of combined doxorubicin and GSNO treatment involves the glutathionylation of histones through a mechanism that requires high glutathione levels and increased expression of GSTP1-1.	S-Nitrosoglutathione	86-90	glutathione S-transferase pi 1	Homo sapiens	230-237
21914835-6	2011	Addition of human recombinant GSTA1, GSTA2, GSTM1, or GSTP1 protein to the incubation mixture further increased the GSH conjugates.	Glutathione	116-119	glutathione S-transferase pi 1	Homo sapiens	54-59
21890734-9	2011	This work shows that drug-metabolizing CYP102A1 mutants, in combination with GSTs, are very useful tools for the generation of GSH conjugates of reactive metabolites of drugs to enable their isolation and structural elucidation.	Glutathione	127-130	glutathione S-transferase pi 1	Homo sapiens	77-81
22052999-7	2011	Treatment with ERbeta antagonist or its natural ligand 5alpha-androstane-3beta,17beta-diol, eNOS inhibitors or ERbeta small interference RNA abrogated the binding and reversed GSTP1 silencing, demonstrating the direct involvement of the complex.	5alpha-androstane-3beta	55-78	glutathione S-transferase pi 1	Homo sapiens	176-181
22126297-11	2011	CONCLUSION: This study showed that the soy phytoestrogens, genistein and daidzein, induce a decrease of methylation of BRCA1, GSTP1 and EPHB2 promoters.	Genistein	59-68	glutathione S-transferase pi 1	Homo sapiens	126-131
22126297-11	2011	CONCLUSION: This study showed that the soy phytoestrogens, genistein and daidzein, induce a decrease of methylation of BRCA1, GSTP1 and EPHB2 promoters.	daidzein	73-81	glutathione S-transferase pi 1	Homo sapiens	126-131
22139572-5	2011	Promoter methylation of three tumor suppressor genes, RASSF1, SFRP1 and GSTP1, was assessed by pyrosequencing of bisulfite-modified DNA.	hydrogen sulfite	113-122	glutathione S-transferase pi 1	Homo sapiens	72-77
22052999-7	2011	Treatment with ERbeta antagonist or its natural ligand 5alpha-androstane-3beta,17beta-diol, eNOS inhibitors or ERbeta small interference RNA abrogated the binding and reversed GSTP1 silencing, demonstrating the direct involvement of the complex.	17beta-diol	79-90	glutathione S-transferase pi 1	Homo sapiens	176-181
21975931-4	2011	Gstp(-/-)/Tg.AC mice exposed to the proinflammatory phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) exhibited higher tumor incidence and multiplicity with a significant thickening of skin after treatment, illustrating hyperproliferative growth.	Phorbol Esters	52-65	glutathione S-transferase pi 1	Homo sapiens	0-4
22047626-0	2011	Oral ezatiostat HCl (Telintra , TLK199) and idiopathic chronic neutropenia (ICN): a case report of complete response of a patient with G-CSF resistant ICN following treatment with ezatiostat, a glutathione S-transferase P1-1 (GSTP1-1) inhibitor.	gamma-Glu-S-BzCys-PhGly diethyl ester	5-15	glutathione S-transferase pi 1	Homo sapiens	226-233
21975931-4	2011	Gstp(-/-)/Tg.AC mice exposed to the proinflammatory phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) exhibited higher tumor incidence and multiplicity with a significant thickening of skin after treatment, illustrating hyperproliferative growth.	Tetradecanoylphorbol Acetate	66-102	glutathione S-transferase pi 1	Homo sapiens	0-4
21975931-4	2011	Gstp(-/-)/Tg.AC mice exposed to the proinflammatory phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) exhibited higher tumor incidence and multiplicity with a significant thickening of skin after treatment, illustrating hyperproliferative growth.	Tetradecanoylphorbol Acetate	104-107	glutathione S-transferase pi 1	Homo sapiens	0-4
21975931-5	2011	Unexpectedly, we observed no difference in cellular proliferation or apoptosis or in markers of oxidative stress, although higher levels of the inflammatory marker nitrotyrosine were found in Gstp(-/-)/Tg.AC mice.	3-nitrotyrosine	164-177	glutathione S-transferase pi 1	Homo sapiens	192-196
21975931-7	2011	Within 4 weeks of TPA treatment, Gstp(-/-)/Tg.AC mice displayed altered lipid/sterol metabolism and Wnt signaling along with aberrant processes of cytoskeletal control and epidermal morphogenesis at both early and late times.	Tetradecanoylphorbol Acetate	18-21	glutathione S-transferase pi 1	Homo sapiens	33-37
21975931-7	2011	Within 4 weeks of TPA treatment, Gstp(-/-)/Tg.AC mice displayed altered lipid/sterol metabolism and Wnt signaling along with aberrant processes of cytoskeletal control and epidermal morphogenesis at both early and late times.	Sterols	78-84	glutathione S-transferase pi 1	Homo sapiens	33-37
22009704-0	2011	Genetic polymorphisms of GSTP1 and XRCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients.	Platinum	76-84	glutathione S-transferase pi 1	Homo sapiens	25-30
22009704-2	2011	Genetic polymorphisms of GSTP1 and XRCC1 involved in glutathione metabolic and DNA repair pathways may explain inter individual differences in chemosensitivity and clinical outcome in NSCLC patients treated with platinum-based regimens.	Glutathione	53-64	glutathione S-transferase pi 1	Homo sapiens	25-30
22009704-2	2011	Genetic polymorphisms of GSTP1 and XRCC1 involved in glutathione metabolic and DNA repair pathways may explain inter individual differences in chemosensitivity and clinical outcome in NSCLC patients treated with platinum-based regimens.	Platinum	212-220	glutathione S-transferase pi 1	Homo sapiens	25-30
22009704-7	2011	CONCLUSION: Genetic polymorphisms of GSTP1 and XRCC1 may be important predictive factors in platinum-treated patients with advanced NSCLC.	Platinum	92-100	glutathione S-transferase pi 1	Homo sapiens	37-42
20232108-0	2011	Cellular resistance to a nitric oxide releasing glutathione S-transferase P-activated prodrug, PABA/NO.	Nitric Oxide	25-37	glutathione S-transferase pi 1	Homo sapiens	48-75
21851097-2	2011	Here we used novel strategies to target microsomal glutathione transferase 1 (MGST1) and glutathione transferase pi (GSTP) that are often overexpressed in tumors and confer resistance against a number of cytostatic drugs, including cisplatin and doxorubicin (DOX).	Cisplatin	232-241	glutathione S-transferase pi 1	Homo sapiens	117-121
21851097-2	2011	Here we used novel strategies to target microsomal glutathione transferase 1 (MGST1) and glutathione transferase pi (GSTP) that are often overexpressed in tumors and confer resistance against a number of cytostatic drugs, including cisplatin and doxorubicin (DOX).	Doxorubicin	246-257	glutathione S-transferase pi 1	Homo sapiens	117-121
21851097-2	2011	Here we used novel strategies to target microsomal glutathione transferase 1 (MGST1) and glutathione transferase pi (GSTP) that are often overexpressed in tumors and confer resistance against a number of cytostatic drugs, including cisplatin and doxorubicin (DOX).	Doxorubicin	259-262	glutathione S-transferase pi 1	Homo sapiens	117-121
21851097-6	2011	Here we synthesized two derivatives of DOX, 2,4-dinitrobenzenesulfonyl doxorubicin (DNS-DOX) and 4-mononitrobenzenesulfonyl doxorubicin (MNS-DOX) and showed that they are substrates for MGST1 and GSTP (releasing DOX).	Doxorubicin	39-42	glutathione S-transferase pi 1	Homo sapiens	196-200
21851097-6	2011	Here we synthesized two derivatives of DOX, 2,4-dinitrobenzenesulfonyl doxorubicin (DNS-DOX) and 4-mononitrobenzenesulfonyl doxorubicin (MNS-DOX) and showed that they are substrates for MGST1 and GSTP (releasing DOX).	2,4-dinitrobenzenesulfonyl doxorubicin	44-82	glutathione S-transferase pi 1	Homo sapiens	196-200
21851097-6	2011	Here we synthesized two derivatives of DOX, 2,4-dinitrobenzenesulfonyl doxorubicin (DNS-DOX) and 4-mononitrobenzenesulfonyl doxorubicin (MNS-DOX) and showed that they are substrates for MGST1 and GSTP (releasing DOX).	dns-dox	84-91	glutathione S-transferase pi 1	Homo sapiens	196-200
21851097-6	2011	Here we synthesized two derivatives of DOX, 2,4-dinitrobenzenesulfonyl doxorubicin (DNS-DOX) and 4-mononitrobenzenesulfonyl doxorubicin (MNS-DOX) and showed that they are substrates for MGST1 and GSTP (releasing DOX).	4-mononitrobenzenesulfonyl doxorubicin	97-135	glutathione S-transferase pi 1	Homo sapiens	196-200
21851097-6	2011	Here we synthesized two derivatives of DOX, 2,4-dinitrobenzenesulfonyl doxorubicin (DNS-DOX) and 4-mononitrobenzenesulfonyl doxorubicin (MNS-DOX) and showed that they are substrates for MGST1 and GSTP (releasing DOX).	mns-dox	137-144	glutathione S-transferase pi 1	Homo sapiens	196-200
21851097-11	2011	In the case of V79 cells, DOX resistance proportional to GSTP expression levels was noted.	Doxorubicin	26-29	glutathione S-transferase pi 1	Homo sapiens	57-61
21851097-12	2011	In this case, not only was drug resistance eliminated by DNS-DOX but a striking GSTP-dependent increase in toxicity was observed in the clonogenic assay.	dns-dox	57-64	glutathione S-transferase pi 1	Homo sapiens	80-84
20232108-1	2011	PABA/NO is a diazeniumdiolate selectively activated by glutathione S-transferase P (GSTP) to release nitric oxide (NO) and is a potent inducer of protein S-glutathionylation, a redox-sensitive post-translational modification of cysteine residues.	diazeniumdiolate	13-29	glutathione S-transferase pi 1	Homo sapiens	84-88
20232108-1	2011	PABA/NO is a diazeniumdiolate selectively activated by glutathione S-transferase P (GSTP) to release nitric oxide (NO) and is a potent inducer of protein S-glutathionylation, a redox-sensitive post-translational modification of cysteine residues.	Nitric Oxide	101-113	glutathione S-transferase pi 1	Homo sapiens	55-82
20232108-1	2011	PABA/NO is a diazeniumdiolate selectively activated by glutathione S-transferase P (GSTP) to release nitric oxide (NO) and is a potent inducer of protein S-glutathionylation, a redox-sensitive post-translational modification of cysteine residues.	Nitric Oxide	101-113	glutathione S-transferase pi 1	Homo sapiens	84-88
20232108-1	2011	PABA/NO is a diazeniumdiolate selectively activated by glutathione S-transferase P (GSTP) to release nitric oxide (NO) and is a potent inducer of protein S-glutathionylation, a redox-sensitive post-translational modification of cysteine residues.	Cysteine	228-236	glutathione S-transferase pi 1	Homo sapiens	55-82
20232108-0	2011	Cellular resistance to a nitric oxide releasing glutathione S-transferase P-activated prodrug, PABA/NO.	4-Aminobenzoic Acid	95-99	glutathione S-transferase pi 1	Homo sapiens	48-75
20232108-1	2011	PABA/NO is a diazeniumdiolate selectively activated by glutathione S-transferase P (GSTP) to release nitric oxide (NO) and is a potent inducer of protein S-glutathionylation, a redox-sensitive post-translational modification of cysteine residues.	Cysteine	228-236	glutathione S-transferase pi 1	Homo sapiens	84-88
20232108-8	2011	Mechanistically, PABA/NO resistance is mediated through reduced levels of GSTP resulting in reduced NO release and its subsequent alterations in cellular response to nitrosative stress.	4-Aminobenzoic Acid	17-21	glutathione S-transferase pi 1	Homo sapiens	74-78
20232108-1	2011	PABA/NO is a diazeniumdiolate selectively activated by glutathione S-transferase P (GSTP) to release nitric oxide (NO) and is a potent inducer of protein S-glutathionylation, a redox-sensitive post-translational modification of cysteine residues.	4-Aminobenzoic Acid	0-4	glutathione S-transferase pi 1	Homo sapiens	55-82
20232108-1	2011	PABA/NO is a diazeniumdiolate selectively activated by glutathione S-transferase P (GSTP) to release nitric oxide (NO) and is a potent inducer of protein S-glutathionylation, a redox-sensitive post-translational modification of cysteine residues.	4-Aminobenzoic Acid	0-4	glutathione S-transferase pi 1	Homo sapiens	84-88
20232108-1	2011	PABA/NO is a diazeniumdiolate selectively activated by glutathione S-transferase P (GSTP) to release nitric oxide (NO) and is a potent inducer of protein S-glutathionylation, a redox-sensitive post-translational modification of cysteine residues.	diazeniumdiolate	13-29	glutathione S-transferase pi 1	Homo sapiens	55-82
21855532-0	2011	Glutathione-S-transferase pi 1(GSTP1) gene silencing in prostate cancer cells is reversed by the histone deacetylase inhibitor depsipeptide.	Depsipeptides	127-139	glutathione S-transferase pi 1	Homo sapiens	0-30
21640195-9	2011	However, the GSTP1 Ile105Val polymorphism was associated with an increase of micronucleated binucleated cells induced by Dox.	Doxorubicin	121-124	glutathione S-transferase pi 1	Homo sapiens	13-18
21640195-11	2011	These results suggest a possible role for GSTP1 on the modulation of the genotoxicity induced by Dox, which may be considered in cancer therapy.	Doxorubicin	97-100	glutathione S-transferase pi 1	Homo sapiens	42-47
21855532-0	2011	Glutathione-S-transferase pi 1(GSTP1) gene silencing in prostate cancer cells is reversed by the histone deacetylase inhibitor depsipeptide.	Depsipeptides	127-139	glutathione S-transferase pi 1	Homo sapiens	31-36
21855532-3	2011	We chose the GSTP1 gene which is silenced by hypermethylation to analyze the effect of the histone deacetylase inhibitor depsipeptide on DNA methylation and histone modifications at the GSTP1 promoter site.	Depsipeptides	121-133	glutathione S-transferase pi 1	Homo sapiens	186-191
21559761-8	2011	Our results suggest that GSTM1 and GSTT1 null genotype alone, both combined or combined with GSTP1 valine alleles, are associated with higher susceptibility to breast cancer development.	Valine	99-105	glutathione S-transferase pi 1	Homo sapiens	93-98
21439344-11	2011	Stimulation with particulates phosphorylated and dephosphorylated several proteins in epithelial cells, and serine and tyrosine protein phosphorylation of GSTP1 decreased.	Tyrosine	119-127	glutathione S-transferase pi 1	Homo sapiens	155-160
21681839-2	2011	However, their effectiveness is limited by drug resistance, which, in some cancers, has been associated with an overexpression of pi class glutathione S-transferase (GST P1-1), an important enzyme in the mercapturic acid detoxification pathway.	Acetylcysteine	204-220	glutathione S-transferase pi 1	Homo sapiens	166-174
21028940-9	2011	Therefore, isofuranonapthoquinone 1 needs further investigations in vivo because of its potent inhibition of GSTP1-1 in vitro.	isofuranonapthoquinone	11-33	glutathione S-transferase pi 1	Homo sapiens	109-116
22335155-5	2011	For genetic polymorphisms, the exposed workers with CYP2E1 or XRCC1 Arg280His variance showed a higher CBMN frequency than their wild-type homozygous counterparts (P = 0.02); so did the workers with GSTP1 105Val/Val genotype or ALDH2 504Glu/Glu genotype than those with a combination of other genotypes (P = 0.01 and 0.003, respectively).	Glutamic Acid	237-240	glutathione S-transferase pi 1	Homo sapiens	199-204
21460233-1	2011	GSH transferases (GSTs) are a superfamily of proteins best known for detoxifying harmful electrophilic compounds by catalyzing their conjugation with GSH.	Glutathione	0-3	glutathione S-transferase pi 1	Homo sapiens	18-22
21439344-4	2011	Herein, we screened differentially phosphorylated proteins in TiO2-treated epithelial cells and validated the change in GSTP1 protein phosphorylation.	titanium dioxide	62-66	glutathione S-transferase pi 1	Homo sapiens	120-125
21286668-1	2011	The aim of this study was to investigate the relationship between the ERCC1-C8092A, ERCC1-C19007T and GSTP1-A105G genetic polymorphisms and the curative effect of cisplatin-based chemotherapy in advanced esophageal carcinoma.	Cisplatin	163-172	glutathione S-transferase pi 1	Homo sapiens	102-107
21489839-4	2011	We observed a significant difference for GSTP1 polymorphisms in SCA patients with the V/V genotype that showed higher glutathione (GSH) and Trolox equivalent antioxidant capacity (TEAC) (p=0.0445 and p=0.0360), respectively, compared with the I/I genotype.	Glutathione	118-129	glutathione S-transferase pi 1	Homo sapiens	41-46
21489839-4	2011	We observed a significant difference for GSTP1 polymorphisms in SCA patients with the V/V genotype that showed higher glutathione (GSH) and Trolox equivalent antioxidant capacity (TEAC) (p=0.0445 and p=0.0360), respectively, compared with the I/I genotype.	Glutathione	131-134	glutathione S-transferase pi 1	Homo sapiens	41-46
21489839-4	2011	We observed a significant difference for GSTP1 polymorphisms in SCA patients with the V/V genotype that showed higher glutathione (GSH) and Trolox equivalent antioxidant capacity (TEAC) (p=0.0445 and p=0.0360), respectively, compared with the I/I genotype.	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	140-146	glutathione S-transferase pi 1	Homo sapiens	41-46
21453686-4	2011	Bisulfite sequencing, methylation-specific PCR and combined bisulfite restriction analysis revealed that GSTP1 promoter was completely methylated in transcriptionally inactive RAJI and MEG-01 cell lines.	hydrogen sulfite	0-9	glutathione S-transferase pi 1	Homo sapiens	105-110
21453686-4	2011	Bisulfite sequencing, methylation-specific PCR and combined bisulfite restriction analysis revealed that GSTP1 promoter was completely methylated in transcriptionally inactive RAJI and MEG-01 cell lines.	hydrogen sulfite	60-69	glutathione S-transferase pi 1	Homo sapiens	105-110
21453686-8	2011	Finally, we provide evidence that treatment of RAJI and MEG-01 cells with the DNA demethylating agent, 5-aza-2"-deoxycytidine, resulted in GSTP1 promoter demethylation, drastic changes of histone modifications and promoter associated proteins and GSTP1 gene activation.	Decitabine	103-125	glutathione S-transferase pi 1	Homo sapiens	139-144
21453686-8	2011	Finally, we provide evidence that treatment of RAJI and MEG-01 cells with the DNA demethylating agent, 5-aza-2"-deoxycytidine, resulted in GSTP1 promoter demethylation, drastic changes of histone modifications and promoter associated proteins and GSTP1 gene activation.	Decitabine	103-125	glutathione S-transferase pi 1	Homo sapiens	247-252
21711528-8	2011	The results showed that GSTP1 could contribute to paclitaxel resistance in EGF-stimulated CNE2 cells.	Paclitaxel	50-60	glutathione S-transferase pi 1	Homo sapiens	24-29
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Valine	62-65	glutathione S-transferase pi 1	Homo sapiens	79-84
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Valine	68-71	glutathione S-transferase pi 1	Homo sapiens	79-84
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Valine	68-71	glutathione S-transferase pi 1	Homo sapiens	79-84
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Aluminum	121-123	glutathione S-transferase pi 1	Homo sapiens	79-84
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Aluminum	202-204	glutathione S-transferase pi 1	Homo sapiens	79-84
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Isoleucine	58-61	glutathione S-transferase pi 1	Homo sapiens	79-84
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Valine	68-71	glutathione S-transferase pi 1	Homo sapiens	79-84
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Valine	68-71	glutathione S-transferase pi 1	Homo sapiens	79-84
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Valine	68-71	glutathione S-transferase pi 1	Homo sapiens	79-84
21729529-8	2011	It is concluded that the GSTP1 gene is related with susceptibility to AML, the AL risk for persons with lle/Val + Val/Val of GSTP1 gene decreased, while CYP2E1 gene is not related with susceptibility to AL, the AML risk for persons in combination of GSTP1 wildtype with CYP2E1 hybrid and mutant genotype can be further decreased.	Aluminum	79-81	glutathione S-transferase pi 1	Homo sapiens	25-30
21729529-8	2011	It is concluded that the GSTP1 gene is related with susceptibility to AML, the AL risk for persons with lle/Val + Val/Val of GSTP1 gene decreased, while CYP2E1 gene is not related with susceptibility to AL, the AML risk for persons in combination of GSTP1 wildtype with CYP2E1 hybrid and mutant genotype can be further decreased.	Aluminum	79-81	glutathione S-transferase pi 1	Homo sapiens	125-130
21729529-8	2011	It is concluded that the GSTP1 gene is related with susceptibility to AML, the AL risk for persons with lle/Val + Val/Val of GSTP1 gene decreased, while CYP2E1 gene is not related with susceptibility to AL, the AML risk for persons in combination of GSTP1 wildtype with CYP2E1 hybrid and mutant genotype can be further decreased.	Aluminum	79-81	glutathione S-transferase pi 1	Homo sapiens	125-130
21729529-8	2011	It is concluded that the GSTP1 gene is related with susceptibility to AML, the AL risk for persons with lle/Val + Val/Val of GSTP1 gene decreased, while CYP2E1 gene is not related with susceptibility to AL, the AML risk for persons in combination of GSTP1 wildtype with CYP2E1 hybrid and mutant genotype can be further decreased.	Aluminum	203-205	glutathione S-transferase pi 1	Homo sapiens	25-30
21729529-8	2011	It is concluded that the GSTP1 gene is related with susceptibility to AML, the AL risk for persons with lle/Val + Val/Val of GSTP1 gene decreased, while CYP2E1 gene is not related with susceptibility to AL, the AML risk for persons in combination of GSTP1 wildtype with CYP2E1 hybrid and mutant genotype can be further decreased.	Aluminum	203-205	glutathione S-transferase pi 1	Homo sapiens	125-130
21729529-8	2011	It is concluded that the GSTP1 gene is related with susceptibility to AML, the AL risk for persons with lle/Val + Val/Val of GSTP1 gene decreased, while CYP2E1 gene is not related with susceptibility to AL, the AML risk for persons in combination of GSTP1 wildtype with CYP2E1 hybrid and mutant genotype can be further decreased.	Aluminum	203-205	glutathione S-transferase pi 1	Homo sapiens	125-130
21269821-3	2011	The novel glutathione transferase P1-1 (GSTP1-1) inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) has recently shown activity against melanoma through c-Jun N-terminal kinase activation.	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	59-106	glutathione S-transferase pi 1	Homo sapiens	40-47
21269821-3	2011	The novel glutathione transferase P1-1 (GSTP1-1) inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) has recently shown activity against melanoma through c-Jun N-terminal kinase activation.	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	108-114	glutathione S-transferase pi 1	Homo sapiens	40-47
21183608-3	2011	We investigated the associations of EPHX1 Tyr113His and His139Arg polymorphisms with asthma and wheezing outcomes, and focused on the functional genetic change in different ambient nitrogen dioxide (NO2) levels on glutathione S-transferase p1 (GSTP1) and glutathione S-transferase m1 (GSTM1) genotypes.	Nitrogen Dioxide	181-197	glutathione S-transferase pi 1	Homo sapiens	214-242
21183608-3	2011	We investigated the associations of EPHX1 Tyr113His and His139Arg polymorphisms with asthma and wheezing outcomes, and focused on the functional genetic change in different ambient nitrogen dioxide (NO2) levels on glutathione S-transferase p1 (GSTP1) and glutathione S-transferase m1 (GSTM1) genotypes.	Nitrogen Dioxide	199-202	glutathione S-transferase pi 1	Homo sapiens	214-242
21183608-9	2011	The increase of the effect from the EPHX1 139Arg allele with higher NO2 exposure was most marked in the GSTP1 Val allele and GSTM1 present genotype.	Nitrogen Dioxide	68-71	glutathione S-transferase pi 1	Homo sapiens	104-109
21216891-0	2011	GSTP1 polymorphism modifies risk for incident asthma associated with nitrogen dioxide in a high-risk birth cohort.	Nitrogen Dioxide	69-85	glutathione S-transferase pi 1	Homo sapiens	0-5
21342130-5	2011	An aim of this review is to summarise recent knowledge on GSTP"s complementary functions in crosstalking pathways of conventional glutathione transfer, nitric oxide and lipid metabolism and ASK1-dependent stress response.	Glutathione	130-141	glutathione S-transferase pi 1	Homo sapiens	58-62
21256954-8	2011	The Nrf2 pathway was activated by BaP and by the flavonoids shown by induction of Nrf2 and several of its target genes such as NQO1, GSTP1, GSTA1 and GCLC.	Flavonoids	49-59	glutathione S-transferase pi 1	Homo sapiens	133-138
21256954-11	2011	Both flavonoids, however, may counteract the effects of BaP on expression of AhR, AhRR, Nrf2, GSTP1 and NQO1.	Flavonoids	5-15	glutathione S-transferase pi 1	Homo sapiens	94-99
21766492-3	2011	Polymorphisms within the GSTP1 may result in alterations in enzyme activity and change sensitivity to platinum-based chemotherapy.	Platinum	102-110	glutathione S-transferase pi 1	Homo sapiens	25-30
21342130-5	2011	An aim of this review is to summarise recent knowledge on GSTP"s complementary functions in crosstalking pathways of conventional glutathione transfer, nitric oxide and lipid metabolism and ASK1-dependent stress response.	Nitric Oxide	152-164	glutathione S-transferase pi 1	Homo sapiens	58-62
21449681-14	2011	Patients with one or two Val alleles of GSTP1 tended to a lower risk of progression compared with Ile/Ile homozygotes, p = 0.067.	Valine	25-28	glutathione S-transferase pi 1	Homo sapiens	40-45
20540076-1	2011	The diuretic drug ethacrynic acid (EA), both an inhibitor and substrate of pi class glutathione S-transferase (GST P1-1), has been tested in clinical trials as an adjuvant in chemotherapy.	Ethacrynic Acid	18-33	glutathione S-transferase pi 1	Homo sapiens	111-119
20540076-1	2011	The diuretic drug ethacrynic acid (EA), both an inhibitor and substrate of pi class glutathione S-transferase (GST P1-1), has been tested in clinical trials as an adjuvant in chemotherapy.	Ethacrynic Acid	35-37	glutathione S-transferase pi 1	Homo sapiens	111-119
21468552-7	2011	A similar reaction has also been observed in patients with the XRCC1 Arg399Gln polymorphism, while patients with the GSTP1 Ile105Val polymorphism have an improved response to oxaliplatin/5FU therapy.	Oxaliplatin	175-186	glutathione S-transferase pi 1	Homo sapiens	117-122
21468552-7	2011	A similar reaction has also been observed in patients with the XRCC1 Arg399Gln polymorphism, while patients with the GSTP1 Ile105Val polymorphism have an improved response to oxaliplatin/5FU therapy.	Fluorouracil	187-190	glutathione S-transferase pi 1	Homo sapiens	117-122
21449681-16	2011	CONCLUSION: In metastatic colorectal cancer patients treated with mFolfox-6, the combination of haplotype XPD Lys751Gln-GSTP1 105Val seems to predict the risk of progression.	mfolfox-6	66-75	glutathione S-transferase pi 1	Homo sapiens	120-125
21133646-0	2011	Clinicopathologic significance of ERCC1, thymidylate synthase and glutathione S-transferase P1 expression for advanced gastric cancer patients receiving adjuvant 5-FU and cisplatin chemotherapy.	Cisplatin	171-180	glutathione S-transferase pi 1	Homo sapiens	66-94
21133646-0	2011	Clinicopathologic significance of ERCC1, thymidylate synthase and glutathione S-transferase P1 expression for advanced gastric cancer patients receiving adjuvant 5-FU and cisplatin chemotherapy.	Fluorouracil	162-166	glutathione S-transferase pi 1	Homo sapiens	66-94
21133646-1	2011	The objective of this study was to determine whether the expressions of the excision cross-complementing (ERCC1), thymidylate synthase (TS) and glutathione S-transferase P1 (GSTP1) are predictive of clinical outcomes in advanced gastric cancer (AGC) patients receiving treatment with adjuvant 5-fluorouracil (5-FU) and cisplatin (FP) chemotherapy.	Fluorouracil	293-307	glutathione S-transferase pi 1	Homo sapiens	174-179
21133646-1	2011	The objective of this study was to determine whether the expressions of the excision cross-complementing (ERCC1), thymidylate synthase (TS) and glutathione S-transferase P1 (GSTP1) are predictive of clinical outcomes in advanced gastric cancer (AGC) patients receiving treatment with adjuvant 5-fluorouracil (5-FU) and cisplatin (FP) chemotherapy.	Fluorouracil	309-313	glutathione S-transferase pi 1	Homo sapiens	174-179
21133646-1	2011	The objective of this study was to determine whether the expressions of the excision cross-complementing (ERCC1), thymidylate synthase (TS) and glutathione S-transferase P1 (GSTP1) are predictive of clinical outcomes in advanced gastric cancer (AGC) patients receiving treatment with adjuvant 5-fluorouracil (5-FU) and cisplatin (FP) chemotherapy.	Cisplatin	319-328	glutathione S-transferase pi 1	Homo sapiens	174-179
21234761-2	2011	We evaluated the influence of common polymorphisms related to DNA repair or xenobiotic pathway (XRCC1, GSTP1, GSTT1, and GSTM1) on the individual susceptibility to CIHM status in the non-neoplastic rectal mucosa in UC patients.	cihm	164-168	glutathione S-transferase pi 1	Homo sapiens	103-108
21234761-5	2011	GSTP1 Val carrier (Ile Val+Val/Val) also held a significantly lower susceptibility to CIHM of the p16 promoter (OR = 0.26, 95%CI = 0.08-0.86, p = 0.028).	Valine	6-9	glutathione S-transferase pi 1	Homo sapiens	0-5
21234761-5	2011	GSTP1 Val carrier (Ile Val+Val/Val) also held a significantly lower susceptibility to CIHM of the p16 promoter (OR = 0.26, 95%CI = 0.08-0.86, p = 0.028).	Valine	23-26	glutathione S-transferase pi 1	Homo sapiens	0-5
21234761-5	2011	GSTP1 Val carrier (Ile Val+Val/Val) also held a significantly lower susceptibility to CIHM of the p16 promoter (OR = 0.26, 95%CI = 0.08-0.86, p = 0.028).	Valine	23-26	glutathione S-transferase pi 1	Homo sapiens	0-5
21234761-8	2011	In addition, the GSTP1 Ile/Val carrier (Ile/Val+Val/Val) was also significantly associated with lower mean number of CIHM (1.43 +- 1.03 vs. 0.84 +- 1.07, p = 0.03).	Valine	27-30	glutathione S-transferase pi 1	Homo sapiens	17-22
21234761-9	2011	XRCC1 Arg399Gln and GSTP1 Ile104Val polymorphisms may influence the CIHM status in the rectal mucosa of UC patients and may be substantially involved in UC-associated carcinogenesis.	cihm	68-72	glutathione S-transferase pi 1	Homo sapiens	20-25
21362365-2	2011	The metabolism of epirubicin (EPI) and cyclophosphamide (CTX) is mainly mediated by cytochrome P450s (CYPs) and glutathione S-transferases (GSTs).	Epirubicin	18-28	glutathione S-transferase pi 1	Homo sapiens	140-144
21545219-11	2011	GSTP1 gene was also found to have novel substitution mutations of A2848 to T and G2849 to A in exon 7 resulting in leucine to leucine and alanine to threonine formation respectively.	Leucine	115-122	glutathione S-transferase pi 1	Homo sapiens	0-5
21545219-11	2011	GSTP1 gene was also found to have novel substitution mutations of A2848 to T and G2849 to A in exon 7 resulting in leucine to leucine and alanine to threonine formation respectively.	Leucine	126-133	glutathione S-transferase pi 1	Homo sapiens	0-5
21545219-11	2011	GSTP1 gene was also found to have novel substitution mutations of A2848 to T and G2849 to A in exon 7 resulting in leucine to leucine and alanine to threonine formation respectively.	Alanine	138-145	glutathione S-transferase pi 1	Homo sapiens	0-5
21545219-11	2011	GSTP1 gene was also found to have novel substitution mutations of A2848 to T and G2849 to A in exon 7 resulting in leucine to leucine and alanine to threonine formation respectively.	Threonine	149-158	glutathione S-transferase pi 1	Homo sapiens	0-5
21545219-12	2011	Two intronic deletions of cytosine at positions 1074 and 1466 was found in intron 3 and 4 in patients and no control had these exonic or intronic variants in GSTP1 gene.	Cytosine	26-34	glutathione S-transferase pi 1	Homo sapiens	158-163
21362365-2	2011	The metabolism of epirubicin (EPI) and cyclophosphamide (CTX) is mainly mediated by cytochrome P450s (CYPs) and glutathione S-transferases (GSTs).	Epirubicin	30-33	glutathione S-transferase pi 1	Homo sapiens	140-144
21362365-2	2011	The metabolism of epirubicin (EPI) and cyclophosphamide (CTX) is mainly mediated by cytochrome P450s (CYPs) and glutathione S-transferases (GSTs).	Cyclophosphamide	39-55	glutathione S-transferase pi 1	Homo sapiens	140-144
21980513-0	2011	GSTP1 DNA methylation and expression status is indicative of 5-aza-2"-deoxycytidine efficacy in human prostate cancer cells.	Decitabine	61-83	glutathione S-transferase pi 1	Homo sapiens	0-5
21787681-8	2011	Whereas, bus drivers with GSTP1 Val and GSTM1 null genotypes showed decreasing in excretion of 1-OHP.	Oxaliplatin	95-100	glutathione S-transferase pi 1	Homo sapiens	26-31
21787681-10	2011	This study indicated that 1-OHP concentrations were associated with exposure to air pollution, cigarette smoking and polymorphisms of CYP1A1, GSTM1 and GSTP1 genes.	Oxaliplatin	26-31	glutathione S-transferase pi 1	Homo sapiens	152-157
21734345-9	2011	Combination of 113His/His EPHX1/null-GSTM1 genotypes showed a significant association with the decrease of Delta FEV1 in patients (P =0.028).In conclusion, our results suggest combined EPHX1, GSTP1, GSTM1 and GSTT1 genetic polymorphisms may play a significant role in the development of COPD, emphysema and decline of the lung function.	113his	15-21	glutathione S-transferase pi 1	Homo sapiens	192-197
21520986-9	2011	We found the GSTP protein level and GST activities were higher in the breast tumor than in the normal cytosolic fractions against both CDNB and EPNP, thus implicating a certain biological importance.	Dinitrochlorobenzene	135-139	glutathione S-transferase pi 1	Homo sapiens	13-17
21980513-9	2011	Treatment of LNCaP cells with a more stable DNMTi, Zebularine required at least a 100-fold higher dose (>= 50 microM) to inhibit proliferation and was less potent in inducing cell death, which corresponded to a lack of GSTP1 protein re-expression.	pyrimidin-2-one beta-ribofuranoside	51-61	glutathione S-transferase pi 1	Homo sapiens	222-227
21619788-0	2011	[Modification of GSTM1, GSTT1 and GSTP1 gene polymorphisms on urinary 1-hydroxypyrene excretions].	1-hydroxypyrene	70-85	glutathione S-transferase pi 1	Homo sapiens	34-39
22022436-9	2011	Unlike wild-type or mGstp1/2-/- mice, when hGSTP1+mGstp1/2-/- mice were overdosed with acetaminophen, liver tissues showed limited centrilobular necrosis, suggesting that pi-class GSTs may be critical determinants of toxin-induced hepatocyte injury even when not expressed by hepatocytes.	Acetaminophen	87-100	glutathione S-transferase pi 1	Homo sapiens	43-58
21619788-1	2011	OBJECTIVE: To investigate the modification of GSTM1, GSTT1 and GSTP1 gene polymorphisms on urinary 1-hydroxypyrene (1-OHP) excretions in workers under different exposure levels.	1-hydroxypyrene	99-114	glutathione S-transferase pi 1	Homo sapiens	63-68
21619788-1	2011	OBJECTIVE: To investigate the modification of GSTM1, GSTT1 and GSTP1 gene polymorphisms on urinary 1-hydroxypyrene (1-OHP) excretions in workers under different exposure levels.	Oxaliplatin	116-121	glutathione S-transferase pi 1	Homo sapiens	63-68
20499266-6	2010	Two polymorphic sites of Ile105Val and Ala114Val in exons 5 and 6 respectively, of the GSTP1 gene were analysed.	ile105val	25-34	glutathione S-transferase pi 1	Homo sapiens	87-92
21619788-5	2011	After controlling potential confounders, decreased excretion of urinary 1-OHP was associated with GSTP1 I105V AG + GG genotype in coke oven workers (single-gene model, P = 0.012; multi-gene model, P = 0.011) and with GSTT1 null type in the analysis including all subjects (P = 0.055 in both single-gene and multi-gene models).	Oxaliplatin	72-77	glutathione S-transferase pi 1	Homo sapiens	98-103
21619788-6	2011	GSTT1 and GSTP1 were interacted on the urinary concentrations of 1-OHP.	Oxaliplatin	65-70	glutathione S-transferase pi 1	Homo sapiens	10-15
21619788-7	2011	CONCLUSION: Urinary 1-OHP concentrations can be modified by GSTM1, GSTT1 and GSTP1 gene polymorphisms, indicating that these genes are involved in the metabolism of polycyclic aromatic hydrocarbons.	Oxaliplatin	20-25	glutathione S-transferase pi 1	Homo sapiens	77-82
21619788-7	2011	CONCLUSION: Urinary 1-OHP concentrations can be modified by GSTM1, GSTT1 and GSTP1 gene polymorphisms, indicating that these genes are involved in the metabolism of polycyclic aromatic hydrocarbons.	Polycyclic Aromatic Hydrocarbons	165-197	glutathione S-transferase pi 1	Homo sapiens	77-82
20836986-7	2010	Furthermore, adduction of GST P1-1 by HNE eliminated its activity toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB) and toward HNE itself.	Dinitrochlorobenzene	88-115	glutathione S-transferase pi 1	Homo sapiens	26-32
20836986-7	2010	Furthermore, adduction of GST P1-1 by HNE eliminated its activity toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB) and toward HNE itself.	Dinitrochlorobenzene	117-121	glutathione S-transferase pi 1	Homo sapiens	26-32
21079113-10	2010	The variant Val allele at the GSTP1 105 codon was associated with a significantly increased risk of surgical complications (P = .046; adjusted relative risk, 1.7; 95% confidence interval, 1.1-2.6).	Valine	12-15	glutathione S-transferase pi 1	Homo sapiens	30-35
21128213-4	2010	Patients who had the Val allele of the GSTP1 Ile105Val polymorphism had an increased risk of tumor development (odds ratio = 8.60; 95% confidence interval = 4.74-17.87; P < 0.001).	Valine	21-24	glutathione S-transferase pi 1	Homo sapiens	39-44
20979931-0	2010	Associations between oxaliplatin-induced peripheral neuropathy and polymorphisms of the ERCC1 and GSTP1 genes.	Oxaliplatin	21-32	glutathione S-transferase pi 1	Homo sapiens	98-103
20979931-6	2010	CONCLUSIONS: Our results suggest that ERCC1, C118T and GSTP1 Ile105Val polymorphisms are more strongly related to the time until onset of neuropathy than to the grade of neuropathy.	ile105val	61-70	glutathione S-transferase pi 1	Homo sapiens	55-60
20858151-3	2010	OBJECTIVE: To examine the role of polymorphisms in GSTP1 (Ile105Val and Ala114Val), alone and in combination with ETS exposure, on atopy and asthma severity.	ile105val	58-67	glutathione S-transferase pi 1	Homo sapiens	51-56
20849150-6	2010	In the presence of three of the GSTs, hGST P1-1, hGST M1-1, and hGST A1-1, total GSH conjugation was strongly increased in all bioactivation systems tested.	Glutathione	81-84	glutathione S-transferase pi 1	Homo sapiens	38-47
20654585-0	2010	Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCalpha enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells.	Serine	0-6	glutathione S-transferase pi 1	Homo sapiens	26-54
20654585-0	2010	Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCalpha enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells.	Serine	0-6	glutathione S-transferase pi 1	Homo sapiens	56-61
20654585-0	2010	Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCalpha enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells.	Serine	0-6	glutathione S-transferase pi 1	Homo sapiens	84-89
20654585-0	2010	Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCalpha enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells.	Cisplatin	100-109	glutathione S-transferase pi 1	Homo sapiens	26-54
20654585-0	2010	Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCalpha enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells.	Cisplatin	100-109	glutathione S-transferase pi 1	Homo sapiens	56-61
20654585-0	2010	Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCalpha enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells.	Cisplatin	100-109	glutathione S-transferase pi 1	Homo sapiens	84-89
20654585-2	2010	In this study, we investigated the contribution of this post-translational modification of GSTP1 to tumor cisplatin resistance.	Cisplatin	106-115	glutathione S-transferase pi 1	Homo sapiens	91-96
20853826-6	2010	In the present work, we have resorted to density functional theory (DFT) and to potential of mean force (PMF) calculations to determine the GSH activation mechanism of GSTP1-1 and GSTM1-1 isoenzymes.	Glutathione	140-143	glutathione S-transferase pi 1	Homo sapiens	168-175
20853826-7	2010	For the GSTP1-1 enzyme, we have demonstrated that a water molecule, after an initial conformational rearrangement of GSH, can assist a proton transfer between the GSH cysteine thiol (GSH-SH) and the GSH glutamate alpha carboxylate (GSH-COO(-)) groups.	Water	52-57	glutathione S-transferase pi 1	Homo sapiens	8-15
20853826-7	2010	For the GSTP1-1 enzyme, we have demonstrated that a water molecule, after an initial conformational rearrangement of GSH, can assist a proton transfer between the GSH cysteine thiol (GSH-SH) and the GSH glutamate alpha carboxylate (GSH-COO(-)) groups.	Glutathione	117-120	glutathione S-transferase pi 1	Homo sapiens	8-15
20853826-7	2010	For the GSTP1-1 enzyme, we have demonstrated that a water molecule, after an initial conformational rearrangement of GSH, can assist a proton transfer between the GSH cysteine thiol (GSH-SH) and the GSH glutamate alpha carboxylate (GSH-COO(-)) groups.	gsh cysteine thiol	163-181	glutathione S-transferase pi 1	Homo sapiens	8-15
20853826-7	2010	For the GSTP1-1 enzyme, we have demonstrated that a water molecule, after an initial conformational rearrangement of GSH, can assist a proton transfer between the GSH cysteine thiol (GSH-SH) and the GSH glutamate alpha carboxylate (GSH-COO(-)) groups.	Glutathione	163-166	glutathione S-transferase pi 1	Homo sapiens	8-15
20853826-7	2010	For the GSTP1-1 enzyme, we have demonstrated that a water molecule, after an initial conformational rearrangement of GSH, can assist a proton transfer between the GSH cysteine thiol (GSH-SH) and the GSH glutamate alpha carboxylate (GSH-COO(-)) groups.	gsh glutamate alpha carboxylate	199-230	glutathione S-transferase pi 1	Homo sapiens	8-15
20853826-7	2010	For the GSTP1-1 enzyme, we have demonstrated that a water molecule, after an initial conformational rearrangement of GSH, can assist a proton transfer between the GSH cysteine thiol (GSH-SH) and the GSH glutamate alpha carboxylate (GSH-COO(-)) groups.	Glutathione	163-166	glutathione S-transferase pi 1	Homo sapiens	8-15
20853826-7	2010	For the GSTP1-1 enzyme, we have demonstrated that a water molecule, after an initial conformational rearrangement of GSH, can assist a proton transfer between the GSH cysteine thiol (GSH-SH) and the GSH glutamate alpha carboxylate (GSH-COO(-)) groups.	carboxyl radical	236-239	glutathione S-transferase pi 1	Homo sapiens	8-15
20701904-7	2010	Among the 27 risk factors assessed, lower maternal social class, maternal smoking during pregnancy, being first born, shorter breastfeeding, higher DDT levels in cord blood, and higher indoor levels of NO2 (among the non-detoxifiers by GSTP1 polymorphism) were independently associated with poorer cognition.	Nitrogen Dioxide	202-205	glutathione S-transferase pi 1	Homo sapiens	236-241
20654585-3	2010	Using two malignant glioma cell lines, MGR1 and MGR3, the ability of PKCalpha-phosphorylated GSTP1 to catalyze the conjugation of cisplatin to glutathione was assessed and correlated with cisplatin sensitivity and cisplatin-induced DNA interstrand cross-links and apoptosis of the cells.	Cisplatin	130-139	glutathione S-transferase pi 1	Homo sapiens	93-98
20654585-3	2010	Using two malignant glioma cell lines, MGR1 and MGR3, the ability of PKCalpha-phosphorylated GSTP1 to catalyze the conjugation of cisplatin to glutathione was assessed and correlated with cisplatin sensitivity and cisplatin-induced DNA interstrand cross-links and apoptosis of the cells.	Glutathione	143-154	glutathione S-transferase pi 1	Homo sapiens	93-98
20654585-3	2010	Using two malignant glioma cell lines, MGR1 and MGR3, the ability of PKCalpha-phosphorylated GSTP1 to catalyze the conjugation of cisplatin to glutathione was assessed and correlated with cisplatin sensitivity and cisplatin-induced DNA interstrand cross-links and apoptosis of the cells.	Cisplatin	188-197	glutathione S-transferase pi 1	Homo sapiens	93-98
20654585-3	2010	Using two malignant glioma cell lines, MGR1 and MGR3, the ability of PKCalpha-phosphorylated GSTP1 to catalyze the conjugation of cisplatin to glutathione was assessed and correlated with cisplatin sensitivity and cisplatin-induced DNA interstrand cross-links and apoptosis of the cells.	Cisplatin	188-197	glutathione S-transferase pi 1	Homo sapiens	93-98
20654585-4	2010	The results showed PKCalpha activation and associated phosphorylation of GSTP1 to correlate significantly with increased glutathionylplatinum formation, decreased DNA interstrand cross-link formation and increased cisplatin resistance.	Cisplatin	214-223	glutathione S-transferase pi 1	Homo sapiens	73-78
20654585-6	2010	In both cell lines, siRNA-mediated GSTP1 or PKCalpha transcriptional suppression similarly decreased cisplatin IC(50) and was associated with decreased intracellular levels of glutathionylplatinum metabolite.	Cisplatin	101-110	glutathione S-transferase pi 1	Homo sapiens	35-40
20654585-7	2010	Combined inhibition/transcriptional suppression of both PKCalpha and GSTP1 was synergistic in enhancing cisplatin sensitivity.	Cisplatin	104-113	glutathione S-transferase pi 1	Homo sapiens	69-74
20654585-8	2010	Although, cisplatin-induced apoptosis was associated with the translocation of Bax to mitochondria, release of cytochrome c and caspase-3/7 activation, the levels of relocalized Bax and cytochrome c were significantly greater following GSTP1 knockdown.	Cisplatin	10-19	glutathione S-transferase pi 1	Homo sapiens	236-241
20654585-9	2010	These results support a mechanism of cisplatin resistance mediated by the PKCalpha-dependent serine phosphorylation of GSTP1 and its associated increased cisplatin metabolism, and suggest the potential of simultaneous targeting of GSTP1 and PKCalpha to improve the efficacy of cisplatin therapy.	Cisplatin	37-46	glutathione S-transferase pi 1	Homo sapiens	119-124
20654585-9	2010	These results support a mechanism of cisplatin resistance mediated by the PKCalpha-dependent serine phosphorylation of GSTP1 and its associated increased cisplatin metabolism, and suggest the potential of simultaneous targeting of GSTP1 and PKCalpha to improve the efficacy of cisplatin therapy.	Cisplatin	37-46	glutathione S-transferase pi 1	Homo sapiens	231-236
20654585-9	2010	These results support a mechanism of cisplatin resistance mediated by the PKCalpha-dependent serine phosphorylation of GSTP1 and its associated increased cisplatin metabolism, and suggest the potential of simultaneous targeting of GSTP1 and PKCalpha to improve the efficacy of cisplatin therapy.	Serine	93-99	glutathione S-transferase pi 1	Homo sapiens	119-124
20654585-9	2010	These results support a mechanism of cisplatin resistance mediated by the PKCalpha-dependent serine phosphorylation of GSTP1 and its associated increased cisplatin metabolism, and suggest the potential of simultaneous targeting of GSTP1 and PKCalpha to improve the efficacy of cisplatin therapy.	Cisplatin	154-163	glutathione S-transferase pi 1	Homo sapiens	119-124
20654585-9	2010	These results support a mechanism of cisplatin resistance mediated by the PKCalpha-dependent serine phosphorylation of GSTP1 and its associated increased cisplatin metabolism, and suggest the potential of simultaneous targeting of GSTP1 and PKCalpha to improve the efficacy of cisplatin therapy.	Cisplatin	154-163	glutathione S-transferase pi 1	Homo sapiens	119-124
20820671-3	2010	Over the past decade, our laboratory has identified and characterized several carotenoid-binding proteins from human retina including a pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein, a member of the steroidogenic acute regulatory domain (StARD) family as a lutein-binding protein, and tubulin as a less specific, but higher capacity site for carotenoid deposition.	Carotenoids	78-88	glutathione S-transferase pi 1	Homo sapiens	177-182
20820671-3	2010	Over the past decade, our laboratory has identified and characterized several carotenoid-binding proteins from human retina including a pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein, a member of the steroidogenic acute regulatory domain (StARD) family as a lutein-binding protein, and tubulin as a less specific, but higher capacity site for carotenoid deposition.	Carotenoids	376-386	glutathione S-transferase pi 1	Homo sapiens	177-182
20631055-5	2010	Ethacrynic acid, a classic GSTP1-1 inhibitor, 4-hydroxy-nonenal, hydrogen peroxide, and diamide all induced reversible GSTP1-1 oligomerization in Jurkat leukemia cells through the formation of disulphide bonds involving Cys47 and/or Cys101, as suggested by reducing and nonreducing SDS-polyacrylamide gel electrophoresis analysis of cysteine to serine mutants.	Ethacrynic Acid	0-15	glutathione S-transferase pi 1	Homo sapiens	27-34
20631055-5	2010	Ethacrynic acid, a classic GSTP1-1 inhibitor, 4-hydroxy-nonenal, hydrogen peroxide, and diamide all induced reversible GSTP1-1 oligomerization in Jurkat leukemia cells through the formation of disulphide bonds involving Cys47 and/or Cys101, as suggested by reducing and nonreducing SDS-polyacrylamide gel electrophoresis analysis of cysteine to serine mutants.	Ethacrynic Acid	0-15	glutathione S-transferase pi 1	Homo sapiens	119-126
20631055-5	2010	Ethacrynic acid, a classic GSTP1-1 inhibitor, 4-hydroxy-nonenal, hydrogen peroxide, and diamide all induced reversible GSTP1-1 oligomerization in Jurkat leukemia cells through the formation of disulphide bonds involving Cys47 and/or Cys101, as suggested by reducing and nonreducing SDS-polyacrylamide gel electrophoresis analysis of cysteine to serine mutants.	4-hydroxy-2-nonenal	46-63	glutathione S-transferase pi 1	Homo sapiens	119-126
20631055-5	2010	Ethacrynic acid, a classic GSTP1-1 inhibitor, 4-hydroxy-nonenal, hydrogen peroxide, and diamide all induced reversible GSTP1-1 oligomerization in Jurkat leukemia cells through the formation of disulphide bonds involving Cys47 and/or Cys101, as suggested by reducing and nonreducing SDS-polyacrylamide gel electrophoresis analysis of cysteine to serine mutants.	Hydrogen Peroxide	65-82	glutathione S-transferase pi 1	Homo sapiens	119-126
20631055-5	2010	Ethacrynic acid, a classic GSTP1-1 inhibitor, 4-hydroxy-nonenal, hydrogen peroxide, and diamide all induced reversible GSTP1-1 oligomerization in Jurkat leukemia cells through the formation of disulphide bonds involving Cys47 and/or Cys101, as suggested by reducing and nonreducing SDS-polyacrylamide gel electrophoresis analysis of cysteine to serine mutants.	Diamide	88-95	glutathione S-transferase pi 1	Homo sapiens	119-126
20631055-5	2010	Ethacrynic acid, a classic GSTP1-1 inhibitor, 4-hydroxy-nonenal, hydrogen peroxide, and diamide all induced reversible GSTP1-1 oligomerization in Jurkat leukemia cells through the formation of disulphide bonds involving Cys47 and/or Cys101, as suggested by reducing and nonreducing SDS-polyacrylamide gel electrophoresis analysis of cysteine to serine mutants.	disulphide	193-203	glutathione S-transferase pi 1	Homo sapiens	119-126
20631055-5	2010	Ethacrynic acid, a classic GSTP1-1 inhibitor, 4-hydroxy-nonenal, hydrogen peroxide, and diamide all induced reversible GSTP1-1 oligomerization in Jurkat leukemia cells through the formation of disulphide bonds involving Cys47 and/or Cys101, as suggested by reducing and nonreducing SDS-polyacrylamide gel electrophoresis analysis of cysteine to serine mutants.	Sodium Dodecyl Sulfate	282-285	glutathione S-transferase pi 1	Homo sapiens	119-126
20631055-5	2010	Ethacrynic acid, a classic GSTP1-1 inhibitor, 4-hydroxy-nonenal, hydrogen peroxide, and diamide all induced reversible GSTP1-1 oligomerization in Jurkat leukemia cells through the formation of disulphide bonds involving Cys47 and/or Cys101, as suggested by reducing and nonreducing SDS-polyacrylamide gel electrophoresis analysis of cysteine to serine mutants.	polyacrylamide	286-300	glutathione S-transferase pi 1	Homo sapiens	119-126
20631055-5	2010	Ethacrynic acid, a classic GSTP1-1 inhibitor, 4-hydroxy-nonenal, hydrogen peroxide, and diamide all induced reversible GSTP1-1 oligomerization in Jurkat leukemia cells through the formation of disulphide bonds involving Cys47 and/or Cys101, as suggested by reducing and nonreducing SDS-polyacrylamide gel electrophoresis analysis of cysteine to serine mutants.	Cysteine	333-341	glutathione S-transferase pi 1	Homo sapiens	119-126
20631055-5	2010	Ethacrynic acid, a classic GSTP1-1 inhibitor, 4-hydroxy-nonenal, hydrogen peroxide, and diamide all induced reversible GSTP1-1 oligomerization in Jurkat leukemia cells through the formation of disulphide bonds involving Cys47 and/or Cys101, as suggested by reducing and nonreducing SDS-polyacrylamide gel electrophoresis analysis of cysteine to serine mutants.	Serine	345-351	glutathione S-transferase pi 1	Homo sapiens	119-126
20631055-6	2010	Remarkably, the electrophilic prostanoid 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) induced irreversible GSTP1-1 oligomerization, specifically involving Cys101, a residue present in the human but not in the murine enzyme.	Prostaglandins	30-40	glutathione S-transferase pi 1	Homo sapiens	116-123
20631055-6	2010	Remarkably, the electrophilic prostanoid 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) induced irreversible GSTP1-1 oligomerization, specifically involving Cys101, a residue present in the human but not in the murine enzyme.	15-deoxy-delta(12,14)-prostaglandin j	41-78	glutathione S-transferase pi 1	Homo sapiens	116-123
20631055-6	2010	Remarkably, the electrophilic prostanoid 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) induced irreversible GSTP1-1 oligomerization, specifically involving Cys101, a residue present in the human but not in the murine enzyme.	2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE	87-90	glutathione S-transferase pi 1	Homo sapiens	116-123
20631055-8	2010	It is noteworthy that 15d-PGJ(2) elicited GSTP1-1 cross-linking in vitro, a process that could be mimicked by other dienone cyclopentenone PG, such as Delta(12)-PGJ(2), and by the bifunctional thiol reagent dibromobimane, suggesting that cyclopentenone PG may be directly involved in oligomer formation.	15d-pgj	22-29	glutathione S-transferase pi 1	Homo sapiens	42-49
20631055-8	2010	It is noteworthy that 15d-PGJ(2) elicited GSTP1-1 cross-linking in vitro, a process that could be mimicked by other dienone cyclopentenone PG, such as Delta(12)-PGJ(2), and by the bifunctional thiol reagent dibromobimane, suggesting that cyclopentenone PG may be directly involved in oligomer formation.	dienone cyclopentenone	116-138	glutathione S-transferase pi 1	Homo sapiens	42-49
20631055-8	2010	It is noteworthy that 15d-PGJ(2) elicited GSTP1-1 cross-linking in vitro, a process that could be mimicked by other dienone cyclopentenone PG, such as Delta(12)-PGJ(2), and by the bifunctional thiol reagent dibromobimane, suggesting that cyclopentenone PG may be directly involved in oligomer formation.	delta(12)-pgj	151-164	glutathione S-transferase pi 1	Homo sapiens	42-49
20631055-8	2010	It is noteworthy that 15d-PGJ(2) elicited GSTP1-1 cross-linking in vitro, a process that could be mimicked by other dienone cyclopentenone PG, such as Delta(12)-PGJ(2), and by the bifunctional thiol reagent dibromobimane, suggesting that cyclopentenone PG may be directly involved in oligomer formation.	Sulfhydryl Compounds	193-198	glutathione S-transferase pi 1	Homo sapiens	42-49
20631055-8	2010	It is noteworthy that 15d-PGJ(2) elicited GSTP1-1 cross-linking in vitro, a process that could be mimicked by other dienone cyclopentenone PG, such as Delta(12)-PGJ(2), and by the bifunctional thiol reagent dibromobimane, suggesting that cyclopentenone PG may be directly involved in oligomer formation.	dibromobimane	207-220	glutathione S-transferase pi 1	Homo sapiens	42-49
20631055-8	2010	It is noteworthy that 15d-PGJ(2) elicited GSTP1-1 cross-linking in vitro, a process that could be mimicked by other dienone cyclopentenone PG, such as Delta(12)-PGJ(2), and by the bifunctional thiol reagent dibromobimane, suggesting that cyclopentenone PG may be directly involved in oligomer formation.	cyclopentenone pg	124-141	glutathione S-transferase pi 1	Homo sapiens	42-49
20849150-11	2010	Chlorine substitution of the clozapine nitrenium ion, which so far was only observed in in vivo studies, appeared to be the major pathway of hGST P1-1-catalyzed GSH conjugation, whereas hGST A1-1 and hGST M1-1 also showed significant activity.	Chlorine	0-8	glutathione S-transferase pi 1	Homo sapiens	141-150
20849150-11	2010	Chlorine substitution of the clozapine nitrenium ion, which so far was only observed in in vivo studies, appeared to be the major pathway of hGST P1-1-catalyzed GSH conjugation, whereas hGST A1-1 and hGST M1-1 also showed significant activity.	clozapine nitrenium	29-48	glutathione S-transferase pi 1	Homo sapiens	141-150
20849150-11	2010	Chlorine substitution of the clozapine nitrenium ion, which so far was only observed in in vivo studies, appeared to be the major pathway of hGST P1-1-catalyzed GSH conjugation, whereas hGST A1-1 and hGST M1-1 also showed significant activity.	Glutathione	161-164	glutathione S-transferase pi 1	Homo sapiens	141-150
20849150-12	2010	The second GSH conjugate, previously also only found in in vivo studies, was also formed by hGST P1-1 and to a small extent by hGST A1-1.	Glutathione	11-14	glutathione S-transferase pi 1	Homo sapiens	92-101
20849150-14	2010	Therefore, further studies are required to investigate whether genetic polymorphisms of hGST P1-1 and hGST M1-1 contribute to the interindividual differences in susceptibility to clozapine-induced adverse drug reactions.	Clozapine	179-188	glutathione S-transferase pi 1	Homo sapiens	88-97
21787653-0	2010	Inhibition of cadmium-induced apoptosis by glutathione S-transferase P1 via mitogen-activated protein kinases and mitochondrial pathways.	Cadmium	14-21	glutathione S-transferase pi 1	Homo sapiens	43-71
21787653-4	2010	We showed that in HEK293 cells, silencing of GSTP1 expression through RNA interference reinforced the loss in cell viability induced by Cd(2+).	Cadmium	136-138	glutathione S-transferase pi 1	Homo sapiens	45-50
21787653-5	2010	Overexpression of GSTP1 inhibited loss of mitochondrial membrane potential, prevented cytochrome c release from mitochondria and caspase-3 activation, inhibited mitogen-activated protein kinases (MAPKs) including ERK, JNK and p38, and suppressed apoptosis induced by Cd(2+).	Cadmium	267-269	glutathione S-transferase pi 1	Homo sapiens	18-23
20827430-5	2010	In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity.	Proline	117-120	glutathione S-transferase pi 1	Homo sapiens	329-334
20827430-5	2010	In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity.	Arginine	112-115	glutathione S-transferase pi 1	Homo sapiens	329-334
20731849-3	2010	Changes in expression of glutathione S-transferases (GSTs) and other proteins interacting with glutathione (GSH) in model cell lines could be of particular interest.	Glutathione	25-36	glutathione S-transferase pi 1	Homo sapiens	53-57
20731849-3	2010	Changes in expression of glutathione S-transferases (GSTs) and other proteins interacting with glutathione (GSH) in model cell lines could be of particular interest.	Glutathione	108-111	glutathione S-transferase pi 1	Homo sapiens	53-57
20530282-11	2010	Patients with a homozygous variant genotype for GSTP1 were more likely to discontinue FOLFOX because of neurotoxicity (24% v 10%; P = .01).	Folfox protocol	86-92	glutathione S-transferase pi 1	Homo sapiens	48-53
20524644-9	2010	Therefore after incubation of neuronal cell cultures with nitrosothiol, it was possible to quantitate not only S-nitrosation of GST-P1 but also many other proteins, including novel targets such as ubiquitin carboxyl-terminal esterase L1 (UCHL1).	S-Nitrosothiols	58-70	glutathione S-transferase pi 1	Homo sapiens	128-134
20674822-9	2010	In children with a cotinine level less than 0.1 ng/mL, the risk of AD increased for those carrying 2 GSTP1 Ile-105 alleles (OR, 6.63; 95% CI, 1.46-30.18).	Cotinine	19-27	glutathione S-transferase pi 1	Homo sapiens	101-106
20498004-7	2010	Although both Nrf2 target messages nqo1 and gstp1 are upregulated by BaP in Jurkat cells, only GSTP1 is upregulated at the protein level.	Benzo(a)pyrene	69-72	glutathione S-transferase pi 1	Homo sapiens	44-49
20069434-6	2010	RESULTS: On studying the association of GSTs gene polymorphisms with cervical cancer lesions, the combination of GSTM1 null, GSTT1 null and GSTP1 AA genotypes, independently on smoking habit, seems to be related to a 5.7-fold increased risk of developing CLs with a considerable statistical significance (P = 0.0091).	Chlorine	255-258	glutathione S-transferase pi 1	Homo sapiens	140-145
20044584-7	2010	Based on a two-sample t-test, we compared gene expression and high versus low consumption of quercetin-rich foods and observed an overall upregulation of GSTM1, GSTM2, GSTT2, and GSTP1 as well as a downregulation of specific P450 genes (P-values < 0.05, adjusted for age and smoking status).	Quercetin	93-102	glutathione S-transferase pi 1	Homo sapiens	179-184
21029695-0	2010	[Association between genetic polymorphisms of ERCC1, XRCC1, GSTP1 and survival of advanced gastric cancer patients treated with oxaliplatin/5-Fu-based chemotherapy].	Oxaliplatin	128-139	glutathione S-transferase pi 1	Homo sapiens	60-65
21029695-0	2010	[Association between genetic polymorphisms of ERCC1, XRCC1, GSTP1 and survival of advanced gastric cancer patients treated with oxaliplatin/5-Fu-based chemotherapy].	Fluorouracil	140-144	glutathione S-transferase pi 1	Homo sapiens	60-65
21029695-10	2010	CONCLUSION: Genetic polymorphisms of ERCC1-118, XRCC1-399 and GSTP1-105 are associated with TTP and OS of advanced gastric cancer patients treated with oxaliplatin/5-Fu-based combination chemotherapy as the first-line chemotherapy.	Oxaliplatin	152-163	glutathione S-transferase pi 1	Homo sapiens	62-67
21029695-10	2010	CONCLUSION: Genetic polymorphisms of ERCC1-118, XRCC1-399 and GSTP1-105 are associated with TTP and OS of advanced gastric cancer patients treated with oxaliplatin/5-Fu-based combination chemotherapy as the first-line chemotherapy.	Fluorouracil	164-168	glutathione S-transferase pi 1	Homo sapiens	62-67
19856314-0	2010	Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells.	Polyphenols	61-72	glutathione S-transferase pi 1	Homo sapiens	99-104
19856314-2	2010	We investigated the effects of green tea polyphenols (GTPs) on GSTP1 re-expression and further elucidated its mechanism of action and long-term safety, compared with nucleoside-analog inhibitor of DNA methyltransferase (DNMT), 5-aza-2"-deoxycitidine.	gtps	54-58	glutathione S-transferase pi 1	Homo sapiens	63-68
19856314-3	2010	Exposure of human prostate cancer LNCaP cells to 1-10 microg/ml of GTP for 1-7 days caused a concentration- and time-dependent re-expression of GSTP1, which correlated with DNMT1 inhibition.	Guanosine Triphosphate	67-70	glutathione S-transferase pi 1	Homo sapiens	144-149
19856314-6	2010	Chromatin immunoprecipitation assays demonstrated that cells treated with GTP have reduced MBD2 association with accessible Sp1 binding sites leading to increased binding and transcriptional activation of the GSTP1 gene.	Guanosine Triphosphate	74-77	glutathione S-transferase pi 1	Homo sapiens	209-214
20514304-0	2010	Genetic polymorphism of GSTP1: prediction of clinical outcome to oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer.	Oxaliplatin	65-76	glutathione S-transferase pi 1	Homo sapiens	24-29
20514304-0	2010	Genetic polymorphism of GSTP1: prediction of clinical outcome to oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer.	Fluorouracil	77-81	glutathione S-transferase pi 1	Homo sapiens	24-29
20514304-1	2010	The aim of this study was to evaluate the predictive value of the polymorphism Glutathione S-transferase P1 (GSTP1) Ile(105)Val on oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer.	Oxaliplatin	131-142	glutathione S-transferase pi 1	Homo sapiens	79-107
20514304-1	2010	The aim of this study was to evaluate the predictive value of the polymorphism Glutathione S-transferase P1 (GSTP1) Ile(105)Val on oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer.	Oxaliplatin	131-142	glutathione S-transferase pi 1	Homo sapiens	109-114
20514304-1	2010	The aim of this study was to evaluate the predictive value of the polymorphism Glutathione S-transferase P1 (GSTP1) Ile(105)Val on oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer.	Fluorouracil	143-147	glutathione S-transferase pi 1	Homo sapiens	79-107
20514304-1	2010	The aim of this study was to evaluate the predictive value of the polymorphism Glutathione S-transferase P1 (GSTP1) Ile(105)Val on oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer.	Fluorouracil	143-147	glutathione S-transferase pi 1	Homo sapiens	109-114
20577625-2	2010	The aims of this study was to assess the possible association between the oxidative stress related Glutathione S-Transferase genes (GST-M1, GST-T1, and GST-P1) variants and the olanzapine-induced weight gain in Korean schizophrenic patients.	Olanzapine	177-187	glutathione S-transferase pi 1	Homo sapiens	152-158
20055416-1	2010	Ethacrynic acid (EA) is a glutathione S-transferase P1-1 (GST P1-1) inhibitor with weak antiproliferative ability in tumor cells.	Ethacrynic Acid	17-19	glutathione S-transferase pi 1	Homo sapiens	58-66
20308030-2	2010	In this study, we investigated the associations between oxaliplatin-induced neuropathy and the following polymorphisms: glutathione S-transferase pi (GSTP1) Ile(105)Val, and glyoxylate aminotransferase (AGXT) Pro(11)Leu and AGXT Ile(340)Met.	Oxaliplatin	56-67	glutathione S-transferase pi 1	Homo sapiens	150-155
20032267-7	2010	Meta-analysis of GSTP1 Ile105Val (n = 17) and asthma suggested a possible protective effect of the Val allele, but heterogeneity was extreme.	Valine	29-32	glutathione S-transferase pi 1	Homo sapiens	17-22
20338046-10	2010	FOXC1 proved to be general prognostic factor, while ABCB1 and GSTP1 might be predictive factors for the response to and efficacy of doxorubicin treatment.	Doxorubicin	132-143	glutathione S-transferase pi 1	Homo sapiens	62-67
20055416-1	2010	Ethacrynic acid (EA) is a glutathione S-transferase P1-1 (GST P1-1) inhibitor with weak antiproliferative ability in tumor cells.	Ethacrynic Acid	0-15	glutathione S-transferase pi 1	Homo sapiens	58-66
20055416-4	2010	Our data revealed that those EA oxadiazole analogues had improved antiproliferative activity and most of them had similar or better inhibitory effects on GST P1-1 activity than EA.	Oxadiazoles	32-42	glutathione S-transferase pi 1	Homo sapiens	154-162
20055416-7	2010	Our data suggest that these EA oxadiazole analogues are promising antitumor agents that may act through GST P1-1 inhibition-dependent and/or -independent pathways.	Oxadiazoles	31-41	glutathione S-transferase pi 1	Homo sapiens	104-112
19568750-2	2010	We hypothesize that genetic polymorphisms in metabolising enzymes gene GSTP1 (glutathione S-transferase P1), and MRP2 (multidrug resistance-associated protein 2) (ABCC2), which result in inter-individual differences in metabolism and drug disposition, may predict clinical response to platinum agents in advanced non-small cell lung cancer (NSCLC) patients.	Platinum	285-293	glutathione S-transferase pi 1	Homo sapiens	71-76
19568750-7	2010	RESULTS: The C-->T change of MRP2 C-24T and the A-->G change of GSTP1 Ile105Val polymorphism significantly increased platinum-based chemotherapy response.	Platinum	123-131	glutathione S-transferase pi 1	Homo sapiens	70-75
19568750-2	2010	We hypothesize that genetic polymorphisms in metabolising enzymes gene GSTP1 (glutathione S-transferase P1), and MRP2 (multidrug resistance-associated protein 2) (ABCC2), which result in inter-individual differences in metabolism and drug disposition, may predict clinical response to platinum agents in advanced non-small cell lung cancer (NSCLC) patients.	Platinum	285-293	glutathione S-transferase pi 1	Homo sapiens	78-106
19922504-1	2010	Glutathione S-transferase P1 (GSTP1) participates in detoxification of potentially genotoxic compounds that may alter the efficacy and toxicity of platinum-based chemotherapy.	Platinum	147-155	glutathione S-transferase pi 1	Homo sapiens	0-28
19922504-10	2010	I105V polymorphism in GSTP1, by reducing its enzymatic activity and consequential detoxification to oxaliplatin, could be a key determinant for a better outcome, but more neurotoxicity, to FOLFOX-4 treatment.	Oxaliplatin	100-111	glutathione S-transferase pi 1	Homo sapiens	22-27
19195803-3	2010	Polymorphisms of genes involved in glutathione metabolism, e.g. GSTP1 and GSTM1 are reportedly associated with autistic disorder.	Glutathione	35-46	glutathione S-transferase pi 1	Homo sapiens	64-69
19922504-1	2010	Glutathione S-transferase P1 (GSTP1) participates in detoxification of potentially genotoxic compounds that may alter the efficacy and toxicity of platinum-based chemotherapy.	Platinum	147-155	glutathione S-transferase pi 1	Homo sapiens	30-35
19922504-10	2010	I105V polymorphism in GSTP1, by reducing its enzymatic activity and consequential detoxification to oxaliplatin, could be a key determinant for a better outcome, but more neurotoxicity, to FOLFOX-4 treatment.	Folfox protocol	189-197	glutathione S-transferase pi 1	Homo sapiens	22-27
20032816-0	2010	The GSTP1 Ile105 Val polymorphism modifies the metabolism of toluene di-isocyanate.	Toluene 2,4-Diisocyanate	61-82	glutathione S-transferase pi 1	Homo sapiens	4-9
20032816-10	2010	The findings suggest that GSTP1 genotype should be considered when evaluating biomarkers of TDI exposure in urine and plasma.	Toluene 2,4-Diisocyanate	92-95	glutathione S-transferase pi 1	Homo sapiens	26-31
19850963-12	2010	The risk was modified by a functional polymorphism in GSTP1, suggesting a mechanism involving the glutathione pathway.	Glutathione	98-109	glutathione S-transferase pi 1	Homo sapiens	54-59
19895170-3	2010	We have shown, that application of nested two-stage methylation-specific PCR (MSP) is asuitable method for analysis of epigenetically silenced GSTP1 in formalin-fixed paraffin-embedded (FFPE) tissues from breast cancer patients.	Formaldehyde	152-160	glutathione S-transferase pi 1	Homo sapiens	143-148
19950984-3	2010	Moreover, we describe in detail the interaction of brostallicin with GSH in the presence of GSTP1-1 and GSTM2-2, the predominant GST isoenzymes found within tumor cells.	Glutathione	69-72	glutathione S-transferase pi 1	Homo sapiens	92-99
19950984-5	2010	Direct evidence that both GSTP1-1 and GSTM2-2 isoenzymes catalyze the Michael addition reaction of GSH to brostallicin has been obtained both by an HPLC-MS technique and by a new fluorometric assay.	Glutathione	99-102	glutathione S-transferase pi 1	Homo sapiens	26-33
19950984-5	2010	Direct evidence that both GSTP1-1 and GSTM2-2 isoenzymes catalyze the Michael addition reaction of GSH to brostallicin has been obtained both by an HPLC-MS technique and by a new fluorometric assay.	brostallicin	106-118	glutathione S-transferase pi 1	Homo sapiens	26-33
19950984-8	2010	The kinetic behavior of the reaction between brostallicin and GSH, catalyzed by GSTP1-1, has been studied in detail, and a minimum kinetic scheme that suitably describes the experimental data is provided.	Glutathione	62-65	glutathione S-transferase pi 1	Homo sapiens	80-87
20041472-8	2010	However, our analyses suggest that the 105Val-allele of Ile105Val (GSTP1) may be associated with a lower risk and a severity of TDof and TDlt and that Ile105Val pharmacogenetics may be different in Slavonic Caucasians from that in American Caucasians.	ile105val	56-65	glutathione S-transferase pi 1	Homo sapiens	67-72
19914269-6	2010	Strong correlations between GSTP1 Ile105Val and arsenic exposure level and profile were observed in this study.	Arsenic	48-55	glutathione S-transferase pi 1	Homo sapiens	28-33
19914269-7	2010	Especially, heterozygote of GSTP1 Ile105Val had a higher metabolic capacity from inorganic arsenic to monomethyl arsenic, while the opposite trend was observed for ability of metabolism from As(V) to As(III).	Arsenic	91-98	glutathione S-transferase pi 1	Homo sapiens	28-33
19914269-7	2010	Especially, heterozygote of GSTP1 Ile105Val had a higher metabolic capacity from inorganic arsenic to monomethyl arsenic, while the opposite trend was observed for ability of metabolism from As(V) to As(III).	Arsenic	113-120	glutathione S-transferase pi 1	Homo sapiens	28-33
20082271-4	2010	The search revealed several new potential candidate genes involved in the pathogenesis of inflammatory lung diseases: 25-(OH)-vitamin D(3)-1alpha-hydroxylase (CYP27B1), endothelin-1 (EDN1) and glutathione S-transferase Pi (GSTP1).	25-(oh)-vitamin d	118-135	glutathione S-transferase pi 1	Homo sapiens	223-228
20843134-1	2010	The GSTP1 enzyme plays a key role in biotransformation and bioactivation of certain environmental pollutants such as benzo[a]pyrene-7, 8-diol-9,10-epoxide (BPDE) and other diol epoxides of polycyclic aromatic hydrocarbons.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	117-154	glutathione S-transferase pi 1	Homo sapiens	4-9
20843134-1	2010	The GSTP1 enzyme plays a key role in biotransformation and bioactivation of certain environmental pollutants such as benzo[a]pyrene-7, 8-diol-9,10-epoxide (BPDE) and other diol epoxides of polycyclic aromatic hydrocarbons.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	156-160	glutathione S-transferase pi 1	Homo sapiens	4-9
20843134-1	2010	The GSTP1 enzyme plays a key role in biotransformation and bioactivation of certain environmental pollutants such as benzo[a]pyrene-7, 8-diol-9,10-epoxide (BPDE) and other diol epoxides of polycyclic aromatic hydrocarbons.	diol epoxides	172-185	glutathione S-transferase pi 1	Homo sapiens	4-9
20843134-1	2010	The GSTP1 enzyme plays a key role in biotransformation and bioactivation of certain environmental pollutants such as benzo[a]pyrene-7, 8-diol-9,10-epoxide (BPDE) and other diol epoxides of polycyclic aromatic hydrocarbons.	Polycyclic Aromatic Hydrocarbons	189-221	glutathione S-transferase pi 1	Homo sapiens	4-9
20391126-9	2010	GSTP1 protein levels also showed significant decrease in ESCC when adjusted for age, gender, smoking status, and alcohol use.	Alcohols	113-120	glutathione S-transferase pi 1	Homo sapiens	0-5
19895170-3	2010	We have shown, that application of nested two-stage methylation-specific PCR (MSP) is asuitable method for analysis of epigenetically silenced GSTP1 in formalin-fixed paraffin-embedded (FFPE) tissues from breast cancer patients.	Paraffin	167-175	glutathione S-transferase pi 1	Homo sapiens	143-148
20047135-0	2009	Genetic polymorphisms of GSTP1 related to response to 5-FU-oxaliplatin-based chemotherapy and clinical outcome in advanced colorectal cancer patients.	Fluorouracil	54-58	glutathione S-transferase pi 1	Homo sapiens	25-30
20480816-1	2010	The authors presented a comparative study of polymorphous loci Ile105Val and Ala114Val in GSTP1 gene, C609T and C464T in NQO1 gene, Pro197Leu in GPX1 gene of workers engaged into ethylbenzene-styrene (JSC "Salavatnefteorgsintez") and of apparently healthy individuals without occupational exposure to toxic chemicals.	ile105val	63-72	glutathione S-transferase pi 1	Homo sapiens	90-95
20480816-3	2010	Occurrence of genotypes Ile/ Val of GSTP1 gene, Pro/Leu in GPX1 gene in the main group were lower vs. that in the reference one.	Valine	29-32	glutathione S-transferase pi 1	Homo sapiens	36-41
20047135-0	2009	Genetic polymorphisms of GSTP1 related to response to 5-FU-oxaliplatin-based chemotherapy and clinical outcome in advanced colorectal cancer patients.	Oxaliplatin	59-70	glutathione S-transferase pi 1	Homo sapiens	25-30
20047135-8	2009	CONCLUSION: The GSTP1 105Val/105Val genotype is associated with a higher clinical response rate to oxaliplatin-based chemotherapy and with increased survival of patients with advanced colo-rectal cancer, receiving 5-FU/oxaliplatin chemotherapy.	Oxaliplatin	99-110	glutathione S-transferase pi 1	Homo sapiens	16-21
20047135-8	2009	CONCLUSION: The GSTP1 105Val/105Val genotype is associated with a higher clinical response rate to oxaliplatin-based chemotherapy and with increased survival of patients with advanced colo-rectal cancer, receiving 5-FU/oxaliplatin chemotherapy.	Fluorouracil	214-218	glutathione S-transferase pi 1	Homo sapiens	16-21
20047135-8	2009	CONCLUSION: The GSTP1 105Val/105Val genotype is associated with a higher clinical response rate to oxaliplatin-based chemotherapy and with increased survival of patients with advanced colo-rectal cancer, receiving 5-FU/oxaliplatin chemotherapy.	Oxaliplatin	219-230	glutathione S-transferase pi 1	Homo sapiens	16-21
20137387-0	2009	[Association between CYP2B6, CYP2D6, GSTP1 genetic polymorphisms and urinary styrene metabolites in professional workers].	Styrene	77-84	glutathione S-transferase pi 1	Homo sapiens	37-42
19885602-3	2009	Procaine, a local anesthetic drug, and procainamide, a drug for the treatment of cardiac arrhythmias, have been reported as inhibitors of DNA methylation, causing demethylation and reactivation of methylation-silenced genes such as RARbeta and GSTP1.	Procaine	0-8	glutathione S-transferase pi 1	Homo sapiens	244-249
19885602-3	2009	Procaine, a local anesthetic drug, and procainamide, a drug for the treatment of cardiac arrhythmias, have been reported as inhibitors of DNA methylation, causing demethylation and reactivation of methylation-silenced genes such as RARbeta and GSTP1.	Procainamide	39-51	glutathione S-transferase pi 1	Homo sapiens	244-249
19858398-10	2009	Trends (of doubtful significance) were seen for associations of XRCC1, ERCC2, and GSTP1 with toxicity during irinotecan regimens: XRCC1, primary end point, any irinotecan-containing regimen (P = .045); ERCC2, secondary end point, irinotecan alone (P = .003); GSTP1, secondary end point; IrFU (P = .039); and irinotecan alone (P = .05).	Irinotecan	109-119	glutathione S-transferase pi 1	Homo sapiens	82-87
19858398-13	2009	Further investigation of XRCC1, ERCC2, and GSTP1 as potential predictors of irinotecan toxicity is warranted.	Irinotecan	76-86	glutathione S-transferase pi 1	Homo sapiens	43-48
19643601-3	2009	The glutathione S-transferase P1 gene (GSTP1) is a particularly attractive candidate for colorectal cancer susceptibility because it codes the enzyme involved in the metabolism of environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs).	Polycyclic Aromatic Hydrocarbons	214-246	glutathione S-transferase pi 1	Homo sapiens	4-32
19643601-3	2009	The glutathione S-transferase P1 gene (GSTP1) is a particularly attractive candidate for colorectal cancer susceptibility because it codes the enzyme involved in the metabolism of environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs).	Polycyclic Aromatic Hydrocarbons	214-246	glutathione S-transferase pi 1	Homo sapiens	39-44
19643601-3	2009	The glutathione S-transferase P1 gene (GSTP1) is a particularly attractive candidate for colorectal cancer susceptibility because it codes the enzyme involved in the metabolism of environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs).	Polycyclic Aromatic Hydrocarbons	248-252	glutathione S-transferase pi 1	Homo sapiens	4-32
19643601-3	2009	The glutathione S-transferase P1 gene (GSTP1) is a particularly attractive candidate for colorectal cancer susceptibility because it codes the enzyme involved in the metabolism of environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs).	Polycyclic Aromatic Hydrocarbons	248-252	glutathione S-transferase pi 1	Homo sapiens	39-44
19800383-14	2009	In differentiated cells, butyrate tended to increase GSTO1 and GSTP1.	Butyrates	25-33	glutathione S-transferase pi 1	Homo sapiens	63-68
19696094-3	2009	Herein, we tested the hypothesis that glutathione S-transferase P (GSTP), the GST isoform that displays high catalytic efficiency with acrolein, protects against CY-induced urotoxicity by detoxifying acrolein.	Acrolein	135-143	glutathione S-transferase pi 1	Homo sapiens	67-71
19696094-3	2009	Herein, we tested the hypothesis that glutathione S-transferase P (GSTP), the GST isoform that displays high catalytic efficiency with acrolein, protects against CY-induced urotoxicity by detoxifying acrolein.	Cyclophosphamide	162-164	glutathione S-transferase pi 1	Homo sapiens	67-71
19696094-3	2009	Herein, we tested the hypothesis that glutathione S-transferase P (GSTP), the GST isoform that displays high catalytic efficiency with acrolein, protects against CY-induced urotoxicity by detoxifying acrolein.	Acrolein	200-208	glutathione S-transferase pi 1	Homo sapiens	67-71
19696094-4	2009	Treatment of wild-type (WT) and mGstP1/P2 null (GSTP-null) mice with CY caused hemorrhagic cystitis, edema, albumin extravasation, and sloughing of bladder epithelium; however, CY-induced bladder ulcerations of the lamina propria were more numerous and more severe in GSTP-null mice.	Cyclophosphamide	69-71	glutathione S-transferase pi 1	Homo sapiens	48-52
19696094-4	2009	Treatment of wild-type (WT) and mGstP1/P2 null (GSTP-null) mice with CY caused hemorrhagic cystitis, edema, albumin extravasation, and sloughing of bladder epithelium; however, CY-induced bladder ulcerations of the lamina propria were more numerous and more severe in GSTP-null mice.	Cyclophosphamide	69-71	glutathione S-transferase pi 1	Homo sapiens	268-272
19696094-5	2009	CY treatment also led to greater accumulation of myeloperoxidase-positive cells and specific protein-acrolein adducts in the bladder of GSTP-null than WT mice.	Cyclophosphamide	0-2	glutathione S-transferase pi 1	Homo sapiens	136-140
19696094-6	2009	There was no difference in hepatic microsomal production of acrolein from CY or urinary hydroxypropyl mercapturic acid output between WT and GSTP-null mice, but CY induced greater c-Jun NH(2)-terminal kinase (JNK) and c-Jun, but not extracellular signal-regulated kinase or p38, activation in GSTP-null than in WT mice.	Cyclophosphamide	161-163	glutathione S-transferase pi 1	Homo sapiens	293-297
19696094-7	2009	Pretreatment with mesna (2-mercaptoethane sulfonate sodium) abolished CY toxicity and JNK activation in GSTP-null mice.	Mesna	18-23	glutathione S-transferase pi 1	Homo sapiens	104-108
19696094-7	2009	Pretreatment with mesna (2-mercaptoethane sulfonate sodium) abolished CY toxicity and JNK activation in GSTP-null mice.	Mesna	25-58	glutathione S-transferase pi 1	Homo sapiens	104-108
19696094-8	2009	Taken together, these data support the view that GSTP prevents CY-induced bladder toxicity, in part by detoxifying acrolein.	Cyclophosphamide	63-65	glutathione S-transferase pi 1	Homo sapiens	49-53
19808963-10	2009	One such difference is the presence of Ile(104) in GSTP1-1 close to the bound NBDHEX, whereas the corresponding position is occupied by an alanine in GSTM2-2.	Isoleucine	39-42	glutathione S-transferase pi 1	Homo sapiens	51-58
19247656-0	2009	Polymorphisms in p53, GSTP1 and XRCC1 predict relapse and survival of gastric cancer patients treated with oxaliplatin-based adjuvant chemotherapy.	Oxaliplatin	107-118	glutathione S-transferase pi 1	Homo sapiens	22-27
19247656-6	2009	CONCLUSION: Testing for p53 Arg72Pro, GSTP1 Ile105Val, and XRCC1 Arg399Gln polymorphisms may allow identification of gastric cancer patients who will benefit from oxaliplatin-based adjuvant chemotherapy.	Oxaliplatin	163-174	glutathione S-transferase pi 1	Homo sapiens	38-43
19741569-8	2009	Furthermore, the GSTP1-A-allele was overrepresented within the "good prognosis group" (P = 0.032, OR: 2.407, 95% CI: 1.060-5.469), whereas the GSTM1nulltype was associated with the extent of TC qualifying as "poor prognosis group" (P = 0.025, OR: 2.839, 95% CI: 1.104-7.301).	Technetium	191-193	glutathione S-transferase pi 1	Homo sapiens	17-22
20137387-8	2009	CONCLUSION: Genotypes of CYP2B6, GSTP1 and CYP2D6 are related to susceptibility to the metabolism of styrene in human.	Styrene	101-108	glutathione S-transferase pi 1	Homo sapiens	33-38
20137387-4	2009	RESULTS: The level of urine styrene metabolites level was influenced by genotypes of CYP2B6, CYP2D6 and GSTP1 [(280.28 +/- 100.60) mg/g Cr vs (183.48 +/- 127.52) mg/g Cr, (233.04 +/- 77.56) mg/g Cr vs (152.46 +/- 95.47) mg/g Cr, (32.88 +/- 7.14) mg/g Cr vs (24.47 +/- 5.59) mg/g Cr, P < 0.05)].	Styrene	28-35	glutathione S-transferase pi 1	Homo sapiens	104-109
20137387-4	2009	RESULTS: The level of urine styrene metabolites level was influenced by genotypes of CYP2B6, CYP2D6 and GSTP1 [(280.28 +/- 100.60) mg/g Cr vs (183.48 +/- 127.52) mg/g Cr, (233.04 +/- 77.56) mg/g Cr vs (152.46 +/- 95.47) mg/g Cr, (32.88 +/- 7.14) mg/g Cr vs (24.47 +/- 5.59) mg/g Cr, P < 0.05)].	Chromium	136-138	glutathione S-transferase pi 1	Homo sapiens	104-109
20137387-4	2009	RESULTS: The level of urine styrene metabolites level was influenced by genotypes of CYP2B6, CYP2D6 and GSTP1 [(280.28 +/- 100.60) mg/g Cr vs (183.48 +/- 127.52) mg/g Cr, (233.04 +/- 77.56) mg/g Cr vs (152.46 +/- 95.47) mg/g Cr, (32.88 +/- 7.14) mg/g Cr vs (24.47 +/- 5.59) mg/g Cr, P < 0.05)].	Chromium	167-169	glutathione S-transferase pi 1	Homo sapiens	104-109
20137387-4	2009	RESULTS: The level of urine styrene metabolites level was influenced by genotypes of CYP2B6, CYP2D6 and GSTP1 [(280.28 +/- 100.60) mg/g Cr vs (183.48 +/- 127.52) mg/g Cr, (233.04 +/- 77.56) mg/g Cr vs (152.46 +/- 95.47) mg/g Cr, (32.88 +/- 7.14) mg/g Cr vs (24.47 +/- 5.59) mg/g Cr, P < 0.05)].	Chromium	167-169	glutathione S-transferase pi 1	Homo sapiens	104-109
20137387-4	2009	RESULTS: The level of urine styrene metabolites level was influenced by genotypes of CYP2B6, CYP2D6 and GSTP1 [(280.28 +/- 100.60) mg/g Cr vs (183.48 +/- 127.52) mg/g Cr, (233.04 +/- 77.56) mg/g Cr vs (152.46 +/- 95.47) mg/g Cr, (32.88 +/- 7.14) mg/g Cr vs (24.47 +/- 5.59) mg/g Cr, P < 0.05)].	Chromium	167-169	glutathione S-transferase pi 1	Homo sapiens	104-109
20137387-4	2009	RESULTS: The level of urine styrene metabolites level was influenced by genotypes of CYP2B6, CYP2D6 and GSTP1 [(280.28 +/- 100.60) mg/g Cr vs (183.48 +/- 127.52) mg/g Cr, (233.04 +/- 77.56) mg/g Cr vs (152.46 +/- 95.47) mg/g Cr, (32.88 +/- 7.14) mg/g Cr vs (24.47 +/- 5.59) mg/g Cr, P < 0.05)].	Chromium	167-169	glutathione S-transferase pi 1	Homo sapiens	104-109
20137387-4	2009	RESULTS: The level of urine styrene metabolites level was influenced by genotypes of CYP2B6, CYP2D6 and GSTP1 [(280.28 +/- 100.60) mg/g Cr vs (183.48 +/- 127.52) mg/g Cr, (233.04 +/- 77.56) mg/g Cr vs (152.46 +/- 95.47) mg/g Cr, (32.88 +/- 7.14) mg/g Cr vs (24.47 +/- 5.59) mg/g Cr, P < 0.05)].	Chromium	167-169	glutathione S-transferase pi 1	Homo sapiens	104-109
19665369-1	2009	6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) is a powerful inhibitor of the glutathione transferase P1-1 (GSTP1-1) and causes the disruption of the complex between GSTP1-1 and c-Jun N-terminal Kinase (JNK).	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	0-47	glutathione S-transferase pi 1	Homo sapiens	118-125
19665369-1	2009	6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) is a powerful inhibitor of the glutathione transferase P1-1 (GSTP1-1) and causes the disruption of the complex between GSTP1-1 and c-Jun N-terminal Kinase (JNK).	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	0-47	glutathione S-transferase pi 1	Homo sapiens	176-183
19665369-1	2009	6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) is a powerful inhibitor of the glutathione transferase P1-1 (GSTP1-1) and causes the disruption of the complex between GSTP1-1 and c-Jun N-terminal Kinase (JNK).	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	49-55	glutathione S-transferase pi 1	Homo sapiens	118-125
19665369-1	2009	6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) is a powerful inhibitor of the glutathione transferase P1-1 (GSTP1-1) and causes the disruption of the complex between GSTP1-1 and c-Jun N-terminal Kinase (JNK).	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	49-55	glutathione S-transferase pi 1	Homo sapiens	176-183
19515364-11	2009	GSTP1-114/GSTT1 and GSTP1-105/GCLC combinations showed synergistic effects on hair mercury levels compared to single-gene variants.	Mercury	83-90	glutathione S-transferase pi 1	Homo sapiens	0-5
19459176-4	2009	METHODS: Real-time PCR was used to measure four DNA methylation biomarkers: GSTP1 and three previously unreported candidates associated with the genes RASSF2, HIST1H4K, and TFAP2E in sodium bisulfite-modified DNA.	sodium bisulfite	183-199	glutathione S-transferase pi 1	Homo sapiens	76-81
19542225-6	2009	Both HepG2 and LS180 cells treated with NO-aspirin 2 showed an increase in glutathione S-transferase-P1 (GST-P1), glutamate-cysteine ligase (GCL), and NAD(P)H:quinone oxidoreductase-1 (NQO1) expression.	Aspirin	43-50	glutathione S-transferase pi 1	Homo sapiens	75-103
19542225-6	2009	Both HepG2 and LS180 cells treated with NO-aspirin 2 showed an increase in glutathione S-transferase-P1 (GST-P1), glutamate-cysteine ligase (GCL), and NAD(P)H:quinone oxidoreductase-1 (NQO1) expression.	Aspirin	43-50	glutathione S-transferase pi 1	Homo sapiens	105-111
19661073-1	2009	Detoxification enzymes, especially glutathione S-transferase P1-1 (GSTP1-1), have been implicated in resistance to platinum-based chemotherapy.	Platinum	115-123	glutathione S-transferase pi 1	Homo sapiens	67-74
19515364-11	2009	GSTP1-114/GSTT1 and GSTP1-105/GCLC combinations showed synergistic effects on hair mercury levels compared to single-gene variants.	Mercury	83-90	glutathione S-transferase pi 1	Homo sapiens	20-25
19254954-0	2009	Tyrosine phosphorylation of the human glutathione S-transferase P1 by epidermal growth factor receptor.	Tyrosine	0-8	glutathione S-transferase pi 1	Homo sapiens	38-66
19254954-3	2009	Here, we provide evidence that GSTP1 is a downstream EGFR target and that EGFR binds to and phosphorylates tyrosine residues in the GSTP1 protein in vitro and in vivo.	Tyrosine	107-115	glutathione S-transferase pi 1	Homo sapiens	132-137
19254954-6	2009	In human glioma and breast cancer cells, epidermal growth factor stimulation rapidly increased GSTP1 tyrosine phosphorylation and decreased cisplatin sensitivity.	Tyrosine	101-109	glutathione S-transferase pi 1	Homo sapiens	95-100
19254954-4	2009	Mass spectrometry and mutagenesis analyses in a cell-free system and in gliomas cells identified Tyr-7 and Tyr-198 as major EGFR-specific phospho-acceptor residues in the GSTP1 protein.	Tyrosine	97-100	glutathione S-transferase pi 1	Homo sapiens	171-176
19254954-4	2009	Mass spectrometry and mutagenesis analyses in a cell-free system and in gliomas cells identified Tyr-7 and Tyr-198 as major EGFR-specific phospho-acceptor residues in the GSTP1 protein.	Tyrosine	107-110	glutathione S-transferase pi 1	Homo sapiens	171-176
19330882-0	2009	Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.	Benzo(a)pyrene	86-100	glutathione S-transferase pi 1	Homo sapiens	33-61
19402606-2	2009	Selective concentration of just two of the many dietary carotenoids suggests that uptake and transport of these xanthophyll carotenoids into the human foveal region are mediated by specific xanthophyll-binding proteins such as GSTP1 which has previously been identified as the zeaxanthin-binding protein of the primate macula.	Carotenoids	56-67	glutathione S-transferase pi 1	Homo sapiens	227-232
19402606-2	2009	Selective concentration of just two of the many dietary carotenoids suggests that uptake and transport of these xanthophyll carotenoids into the human foveal region are mediated by specific xanthophyll-binding proteins such as GSTP1 which has previously been identified as the zeaxanthin-binding protein of the primate macula.	Carotenoids	124-135	glutathione S-transferase pi 1	Homo sapiens	227-232
19469519-6	2009	PPD and 2,5-dimethyl-1,4-benzoquinonediamine were also found to selectively modify the reactive Cys 47 residue of GSTP, which has a pK(a) of 3.5-4.2 and therefore exists in a largely protonated form.	2,5-dimethyl-1,4-benzoquinonediamine	8-44	glutathione S-transferase pi 1	Homo sapiens	114-118
19469519-6	2009	PPD and 2,5-dimethyl-1,4-benzoquinonediamine were also found to selectively modify the reactive Cys 47 residue of GSTP, which has a pK(a) of 3.5-4.2 and therefore exists in a largely protonated form.	Cysteine	96-99	glutathione S-transferase pi 1	Homo sapiens	114-118
19358561-7	2009	Treatment of purified GSTP1a-1a with excess NO(2)-LA and NO(2)-OA resulted in the formation of covalent adducts between GSTP1a monomers and nitroalkenes, although separate experiments indicated that such covalent bond formation was not necessary for avid GST-nitroalkene interactions.	nitroalkenes	140-152	glutathione S-transferase pi 1	Homo sapiens	22-27
19358561-7	2009	Treatment of purified GSTP1a-1a with excess NO(2)-LA and NO(2)-OA resulted in the formation of covalent adducts between GSTP1a monomers and nitroalkenes, although separate experiments indicated that such covalent bond formation was not necessary for avid GST-nitroalkene interactions.	nitroalkenes	140-152	glutathione S-transferase pi 1	Homo sapiens	120-125
19358561-7	2009	Treatment of purified GSTP1a-1a with excess NO(2)-LA and NO(2)-OA resulted in the formation of covalent adducts between GSTP1a monomers and nitroalkenes, although separate experiments indicated that such covalent bond formation was not necessary for avid GST-nitroalkene interactions.	nitroalkene	140-151	glutathione S-transferase pi 1	Homo sapiens	22-27
19358561-7	2009	Treatment of purified GSTP1a-1a with excess NO(2)-LA and NO(2)-OA resulted in the formation of covalent adducts between GSTP1a monomers and nitroalkenes, although separate experiments indicated that such covalent bond formation was not necessary for avid GST-nitroalkene interactions.	nitroalkene	140-151	glutathione S-transferase pi 1	Homo sapiens	120-125
19330882-0	2009	Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.	dibenzo(a,l)pyrene	102-120	glutathione S-transferase pi 1	Homo sapiens	33-61
19330882-0	2009	Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.	trans-1,2-dihydro-1,2-naphthalenediol	131-142	glutathione S-transferase pi 1	Homo sapiens	33-61
19330882-1	2009	Polycyclic aromatic hydrocarbons (PAHs) are activated by cytochrome P450 (CYP) isozymes, and a subset of the reactive metabolites generated is detoxified via conjugation with glutathione (GSH) by specific glutathione S-transferases (GSTs).	Polycyclic Aromatic Hydrocarbons	0-32	glutathione S-transferase pi 1	Homo sapiens	233-237
19330882-1	2009	Polycyclic aromatic hydrocarbons (PAHs) are activated by cytochrome P450 (CYP) isozymes, and a subset of the reactive metabolites generated is detoxified via conjugation with glutathione (GSH) by specific glutathione S-transferases (GSTs).	Polycyclic Aromatic Hydrocarbons	34-38	glutathione S-transferase pi 1	Homo sapiens	233-237
19330882-1	2009	Polycyclic aromatic hydrocarbons (PAHs) are activated by cytochrome P450 (CYP) isozymes, and a subset of the reactive metabolites generated is detoxified via conjugation with glutathione (GSH) by specific glutathione S-transferases (GSTs).	Glutathione	175-186	glutathione S-transferase pi 1	Homo sapiens	233-237
19131229-4	2009	Over expression of GST-P1 protected prostate cells from cytotoxicity and DNA damage by the heterocyclic amine carcinogen, while inhibition of expression of GST-P1 by transfecting GST-P1 antisense cDNA or targeted deletion of GST-P1 has been found to sensitize cells to cytotoxic chemicals.	Amines	104-109	glutathione S-transferase pi 1	Homo sapiens	19-25
19157724-1	2009	In a case-control study, association of polymorphism in glutathione-S-transferases (GSTM1, GSTT1, GSTP1), involved in detoxification of reactive oxygen species (ROS), was studied with alcoholic liver cirrhosis.	Reactive Oxygen Species	136-159	glutathione S-transferase pi 1	Homo sapiens	98-103
19183974-6	2009	CONCLUSIONS: Polymorphisms of the GST-P1 gene may influence the effect of antenatal steroids on the newborn lung.	Steroids	84-92	glutathione S-transferase pi 1	Homo sapiens	34-40
19330882-5	2009	The lower B[a]P cytotoxicity in the cells expressing rat CYP1A1, and weaker protection by hGSTP1 co-expression in these cells, were attributable to the much lower fraction of B[a]P metabolism via formation of the 7,8-dihydrodiol intermediate by the rat CYP1A1 compared to hCYP1A1.	7,8-dihydrodiol	213-228	glutathione S-transferase pi 1	Homo sapiens	90-96
19330882-8	2009	Depletion of GSH to 20% of control levels via pretreatment with the de novo GSH biosynthesis inhibitor buthionine sulfoximine reduced the protection against B[a]P cytotoxicity by hGSTP1 from 16-fold to 5-fold, indicating that catalysis of conjugation with GSH, rather than binding or other effects, is responsible for the resistance.	Glutathione	13-16	glutathione S-transferase pi 1	Homo sapiens	179-185
19330882-8	2009	Depletion of GSH to 20% of control levels via pretreatment with the de novo GSH biosynthesis inhibitor buthionine sulfoximine reduced the protection against B[a]P cytotoxicity by hGSTP1 from 16-fold to 5-fold, indicating that catalysis of conjugation with GSH, rather than binding or other effects, is responsible for the resistance.	Glutathione	76-79	glutathione S-transferase pi 1	Homo sapiens	179-185
19330882-8	2009	Depletion of GSH to 20% of control levels via pretreatment with the de novo GSH biosynthesis inhibitor buthionine sulfoximine reduced the protection against B[a]P cytotoxicity by hGSTP1 from 16-fold to 5-fold, indicating that catalysis of conjugation with GSH, rather than binding or other effects, is responsible for the resistance.	Buthionine Sulfoximine	103-125	glutathione S-transferase pi 1	Homo sapiens	179-185
19330882-8	2009	Depletion of GSH to 20% of control levels via pretreatment with the de novo GSH biosynthesis inhibitor buthionine sulfoximine reduced the protection against B[a]P cytotoxicity by hGSTP1 from 16-fold to 5-fold, indicating that catalysis of conjugation with GSH, rather than binding or other effects, is responsible for the resistance.	Glutathione	76-79	glutathione S-transferase pi 1	Homo sapiens	179-185
19358516-3	2009	The reactions of SMX-NO with glutathione (GSH), a synthetic peptide (DS3), and two model proteins, human GSH S-transferase pi (GSTP) and serum albumin (HSA), were investigated by mass spectrometry.	4-Nitrososulfamethoxazole	17-23	glutathione S-transferase pi 1	Homo sapiens	105-125
19358516-6	2009	GSTP was exclusively modified at the reactive Cys47 by SMX-NO and exhibited mass increments of 267, 283, and 299 amu, indicative of sulfinamide, N-hydroxysulfinamide, and N-hydroxysulfonamide adducts, respectively.	4-Nitrososulfamethoxazole	55-61	glutathione S-transferase pi 1	Homo sapiens	0-4
19358516-6	2009	GSTP was exclusively modified at the reactive Cys47 by SMX-NO and exhibited mass increments of 267, 283, and 299 amu, indicative of sulfinamide, N-hydroxysulfinamide, and N-hydroxysulfonamide adducts, respectively.	sulfinamide	132-143	glutathione S-transferase pi 1	Homo sapiens	0-4
19358516-6	2009	GSTP was exclusively modified at the reactive Cys47 by SMX-NO and exhibited mass increments of 267, 283, and 299 amu, indicative of sulfinamide, N-hydroxysulfinamide, and N-hydroxysulfonamide adducts, respectively.	n-hydroxysulfinamide	145-165	glutathione S-transferase pi 1	Homo sapiens	0-4
19358516-6	2009	GSTP was exclusively modified at the reactive Cys47 by SMX-NO and exhibited mass increments of 267, 283, and 299 amu, indicative of sulfinamide, N-hydroxysulfinamide, and N-hydroxysulfonamide adducts, respectively.	N-hydroxysulfonamide	171-191	glutathione S-transferase pi 1	Homo sapiens	0-4
19240225-3	2009	Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue.	Polycyclic Aromatic Hydrocarbons	48-80	glutathione S-transferase pi 1	Homo sapiens	30-35
19240225-4	2009	A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A --> 313G), results in lower activity among individuals who carry the valine allele.	ile105val	66-75	glutathione S-transferase pi 1	Homo sapiens	22-27
19240225-4	2009	A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A --> 313G), results in lower activity among individuals who carry the valine allele.	Valine	154-160	glutathione S-transferase pi 1	Homo sapiens	22-27
19350453-2	2009	Curcumin, a promising chemotherapeutic agent, inhibits human GSTA1-1, GSTM1-1, and GSTP1-1 isoenzymes.	Curcumin	0-8	glutathione S-transferase pi 1	Homo sapiens	83-90
19223573-0	2009	Relationship between GSTP1 Ile(105)Val polymorphism and docetaxel-induced peripheral neuropathy: clinical evidence of a role of oxidative stress in taxane toxicity.	Docetaxel	56-65	glutathione S-transferase pi 1	Homo sapiens	21-26
19223573-6	2009	Patients with GSTP1 (105)Ile/(105)Ile genotype had a higher risk of developing a grade > or = 2 DIPN than did those with other GSTP1 genotypes (8 of 27 versus 2 of 31, respectively, odds ratio 6.11; 95% confidence interval 1.17-31.94; P = 0.03).	diisopropanolnitrosamine	99-103	glutathione S-transferase pi 1	Homo sapiens	14-19
19350453-4	2009	Most of the 34 curcumin analogues showed less potent inhibitory activities towards GSTA1-1, GSTM1-1, and GSTP1-1 than the parent curcumin.	Curcumin	15-23	glutathione S-transferase pi 1	Homo sapiens	105-112
19350453-4	2009	Most of the 34 curcumin analogues showed less potent inhibitory activities towards GSTA1-1, GSTM1-1, and GSTP1-1 than the parent curcumin.	Curcumin	129-137	glutathione S-transferase pi 1	Homo sapiens	105-112
19362955-2	2009	We retrospectively assessed whether single nucleotide polymorphisms (SNP) of DNA-repair genes ERCC1, XPD, XRCC1 and glutathione S-transferase genes GSTP1, GSTT1 and GSTM1 predict overall survival (OS), response and toxicity in 119 non-small-cell lung cancer (NSCLC) patients treated with platinum-based regimens as first- or second-line chemotherapy.	Platinum	288-296	glutathione S-transferase pi 1	Homo sapiens	148-153
19028145-3	2009	OBJECTIVE: We conducted a placebo-controlled dose escalation trial to investigate the in vivo effects of sulforaphane, a naturally occurring potent inducer of Phase II enzymes, on the expression of glutathione-s-transferase M1 (GSTM1), glutathione-s-transferase P1 (GSTP1), NADPH quinone oxidoreductase (NQO1), and hemoxygenase-1 (HO-1) in the upper airway of human subjects.	sulforaphane	105-117	glutathione S-transferase pi 1	Homo sapiens	236-264
19028145-3	2009	OBJECTIVE: We conducted a placebo-controlled dose escalation trial to investigate the in vivo effects of sulforaphane, a naturally occurring potent inducer of Phase II enzymes, on the expression of glutathione-s-transferase M1 (GSTM1), glutathione-s-transferase P1 (GSTP1), NADPH quinone oxidoreductase (NQO1), and hemoxygenase-1 (HO-1) in the upper airway of human subjects.	sulforaphane	105-117	glutathione S-transferase pi 1	Homo sapiens	266-271
18825537-0	2009	Green tea catechins in chemoprevention of cancer: a molecular docking investigation into their interaction with glutathione S-transferase (GST P1-1).	Catechin	10-19	glutathione S-transferase pi 1	Homo sapiens	139-147
19084393-1	2009	PURPOSE: Oxaliplatin is detoxified by conjugation to glutathione via the enzyme Glutathione-S-transferase pi (GSTP1).	Oxaliplatin	9-20	glutathione S-transferase pi 1	Homo sapiens	110-115
19084393-1	2009	PURPOSE: Oxaliplatin is detoxified by conjugation to glutathione via the enzyme Glutathione-S-transferase pi (GSTP1).	Glutathione	53-64	glutathione S-transferase pi 1	Homo sapiens	110-115
19084393-2	2009	The aim of this study is to investigate the association of GSTP1 Ile105Val genetic polymorphism with oxaliplatin efficacy and toxicity in advanced colorectal cancer (ACC) patients.	Oxaliplatin	101-112	glutathione S-transferase pi 1	Homo sapiens	59-64
19396019-0	2009	GSTP1 determines cis-platinum cytotoxicity in gastric adenocarcinoma MGC803 cells: regulation by promoter methylation and extracellular regulated kinase signaling.	Cisplatin	17-29	glutathione S-transferase pi 1	Homo sapiens	0-5
19396019-2	2009	Glutathione S-transferase-pi (GSTP1) belongs to a supergene family of detoxifying enzymes involved in the prevention of DNA damage and subsequent platinum resistance in numerous cancers.	Platinum	146-154	glutathione S-transferase pi 1	Homo sapiens	30-35
19396019-9	2009	Treatment of these cells with 5-aza-2"-deoxycytidine, a DNA methyltransferase inhibitor, restored GSTP1 expression and suppressed sensitivity to CDDP.	Decitabine	30-52	glutathione S-transferase pi 1	Homo sapiens	98-103
19396019-10	2009	The selective mitogen-activated protein kinase/extracellular regulated kinase (ERK) pathway inhibitor PD98059 decreased GSTP1 expression in 5-aza-2"-deoxycytidine-treated cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	102-109	glutathione S-transferase pi 1	Homo sapiens	120-125
19396019-10	2009	The selective mitogen-activated protein kinase/extracellular regulated kinase (ERK) pathway inhibitor PD98059 decreased GSTP1 expression in 5-aza-2"-deoxycytidine-treated cells.	Decitabine	140-162	glutathione S-transferase pi 1	Homo sapiens	120-125
18825537-2	2009	The glutathione S-transferases (GSTs; EC 2.5.1.18) family is a widely distributed phase-II detoxifying enzymes and the GST P1-1 isoenzyme has been shown to catalyze the conjugation of GSH with some alkylating anti-cancer agents, suggesting that over-expression of GST P1-1 would result in tumor cell resistance.	Glutathione	184-187	glutathione S-transferase pi 1	Homo sapiens	119-127
18825537-2	2009	The glutathione S-transferases (GSTs; EC 2.5.1.18) family is a widely distributed phase-II detoxifying enzymes and the GST P1-1 isoenzyme has been shown to catalyze the conjugation of GSH with some alkylating anti-cancer agents, suggesting that over-expression of GST P1-1 would result in tumor cell resistance.	Glutathione	184-187	glutathione S-transferase pi 1	Homo sapiens	264-272
18825537-3	2009	Here we report the docking study of four green tea catechins and four alkylating anticancer drugs into the GST P1-1 model, as GSTs were found to be affected by tea catechins.	Catechin	51-60	glutathione S-transferase pi 1	Homo sapiens	107-115
18825537-3	2009	Here we report the docking study of four green tea catechins and four alkylating anticancer drugs into the GST P1-1 model, as GSTs were found to be affected by tea catechins.	Catechin	164-173	glutathione S-transferase pi 1	Homo sapiens	107-115
19538885-8	2009	The combinations with GSTP1 genotypes and GSTM1 genotypes were related to anthracycline-based chemotherapy efficacy (P = 0.037), and the low GSTs activity group (GSTP1 variant allele + GSTM1 null) showed the best effects (85.7%).	Anthracyclines	74-87	glutathione S-transferase pi 1	Homo sapiens	22-27
19388510-3	2009	The most widely studied group were genes encoded molecules engaged in biotransformations of xenobiotics, in particular potential carcinogens, like alcohol (ADH2) and aldehyde (ALDH2) dehydrogenases, various isoenzymes of cytochrome P450 (CYP1A1, CYP2E1) and glutathione S-transferase (GSTM1, GSTT1, GSTP1).	Alcohols	147-154	glutathione S-transferase pi 1	Homo sapiens	299-304
19538885-9	2009	GSTM1 genotypes and their combinations with GSTP1 and/or CYP3A5*3 genotypes were related to taxane-based therapy efficacy (P < 0.05 for all), and both the low GSTs activity group and the drug slow-metabolising group (low GSTs activity group + CYP3A5*3 wild allele) showed better effects (100%).	taxane	92-98	glutathione S-transferase pi 1	Homo sapiens	44-49
19842992-8	2009	Children with the GSTP1 Val105 allele had significantly lower concentrations of erythrocyte glutathione compared to GSTP1 ILE/ILE homozygotes (P=0.03).	Glutathione	92-103	glutathione S-transferase pi 1	Homo sapiens	18-23
19076156-5	2009	The purpose of this study was to evaluate effects of known allelic variants in CYP2B6, CYP3A4, CYP3A5, GSTA1 and GSTP1 genes on pharmacokinetics of thiotepa and tepa.	Thiotepa	148-156	glutathione S-transferase pi 1	Homo sapiens	113-118
19076156-5	2009	The purpose of this study was to evaluate effects of known allelic variants in CYP2B6, CYP3A4, CYP3A5, GSTA1 and GSTP1 genes on pharmacokinetics of thiotepa and tepa.	Triethylenephosphoramide	152-156	glutathione S-transferase pi 1	Homo sapiens	113-118
19076156-10	2009	RESULTS: The polymorphisms CYP2B6 C1459T, CYP3A4*1B, CYP3A5*3, GSTA1 (C-69T, G-52A) and GSTP1 C341T had a significant effect on clearance of thiotepa or tepa.	Thiotepa	141-149	glutathione S-transferase pi 1	Homo sapiens	88-93
19076156-10	2009	RESULTS: The polymorphisms CYP2B6 C1459T, CYP3A4*1B, CYP3A5*3, GSTA1 (C-69T, G-52A) and GSTP1 C341T had a significant effect on clearance of thiotepa or tepa.	Triethylenephosphoramide	145-149	glutathione S-transferase pi 1	Homo sapiens	88-93
19076156-12	2009	Clearance of thiotepa and tepa was predominantly affected by GSTP1 C341T polymorphism, which had a frequency of 9.3%.	Thiotepa	13-21	glutathione S-transferase pi 1	Homo sapiens	61-66
19076156-12	2009	Clearance of thiotepa and tepa was predominantly affected by GSTP1 C341T polymorphism, which had a frequency of 9.3%.	Triethylenephosphoramide	17-21	glutathione S-transferase pi 1	Homo sapiens	61-66
19076156-15	2009	Patients homozygous for the GSTP1 C341T allele may have enhanced exposure to thiotepa and tepa.	Thiotepa	77-85	glutathione S-transferase pi 1	Homo sapiens	28-33
19076156-15	2009	Patients homozygous for the GSTP1 C341T allele may have enhanced exposure to thiotepa and tepa.	Triethylenephosphoramide	81-85	glutathione S-transferase pi 1	Homo sapiens	28-33
19113979-2	2009	The Pd(II) complex induces both cell growth inhibition and apoptosis of human prostate cancer cells, (LnCaP, PC3, and DU145) through the production of ROS and JNK phosphorylation associated with GSTp1 down-regulation.	Polydioxanone	4-10	glutathione S-transferase pi 1	Homo sapiens	195-200
18449862-2	2009	In this study, we performed association studies between GSH-related genes (GSTM1, GSTP1, GSTO1, GSTT1, GSTT2, GPX1, and GCLM) and schizophrenia in a Japanese population.	Glutathione	56-59	glutathione S-transferase pi 1	Homo sapiens	82-87
19124514-8	2009	There was a weak suggestion that for individuals with the GSTP1 AG or GG genotype, a detectable amount of isothiocyanates further decreases one"s risk of colorectal cancer compared with those with the GSTP1 AA genotype, but the interaction term was not statistically significant (P = 0.09).	Isothiocyanates	106-121	glutathione S-transferase pi 1	Homo sapiens	58-63
19778234-0	2009	GSTM1, GSTT1, and GSTP1 polymorphism in north Indian population and its influence on the hydroquinone-induced in vitro genotoxicity.	hydroquinone	89-101	glutathione S-transferase pi 1	Homo sapiens	18-23
19580344-6	2009	The statistically significant correlation was found also for the combined genotypes of GSTM1 null and GSTP1 valine homozygosity (OR = 2.7, 95% CI: 1.1-6.1, chi2 = 4.5 and P = 0.03).	Valine	108-114	glutathione S-transferase pi 1	Homo sapiens	102-107
19258736-5	2009	The valine GSTP1*B (rs1695) allele was present in 35.1% subjects, while the heterozygous form (isoleucine/valine) was the most prevalent genotype (46.6%).	Valine	4-10	glutathione S-transferase pi 1	Homo sapiens	11-16
18524839-10	2008	A stronger estimated effect of O(3) on FEV(1) was found in subjects carrying both the GSTP1 105Val variant and the HMOX1 long (GT)n repeat (-1.94%, 95% CI: -2.89% to -0.98%).	Ozone	31-35	glutathione S-transferase pi 1	Homo sapiens	86-91
18992797-3	2008	We investigated whether expression of human glutathione S-transferase P1 (hGSTP1) would differentially protect cells against the cytotoxicity or mutagenicity of 5MC or its 1,2-dihydrodiol intermediate (5MC-1,2-diol) in V79MZ cells with activation via stably transfected human CYP1B1 (hCYP1B1) as compared to activation by human CYP1A1 (hCYP1A1).	5-methylchrysene	161-164	glutathione S-transferase pi 1	Homo sapiens	44-72
18992797-3	2008	We investigated whether expression of human glutathione S-transferase P1 (hGSTP1) would differentially protect cells against the cytotoxicity or mutagenicity of 5MC or its 1,2-dihydrodiol intermediate (5MC-1,2-diol) in V79MZ cells with activation via stably transfected human CYP1B1 (hCYP1B1) as compared to activation by human CYP1A1 (hCYP1A1).	5-methylchrysene	161-164	glutathione S-transferase pi 1	Homo sapiens	74-80
18992797-3	2008	We investigated whether expression of human glutathione S-transferase P1 (hGSTP1) would differentially protect cells against the cytotoxicity or mutagenicity of 5MC or its 1,2-dihydrodiol intermediate (5MC-1,2-diol) in V79MZ cells with activation via stably transfected human CYP1B1 (hCYP1B1) as compared to activation by human CYP1A1 (hCYP1A1).	1,2-dihydrodiol	172-187	glutathione S-transferase pi 1	Homo sapiens	44-72
18992797-3	2008	We investigated whether expression of human glutathione S-transferase P1 (hGSTP1) would differentially protect cells against the cytotoxicity or mutagenicity of 5MC or its 1,2-dihydrodiol intermediate (5MC-1,2-diol) in V79MZ cells with activation via stably transfected human CYP1B1 (hCYP1B1) as compared to activation by human CYP1A1 (hCYP1A1).	1,2-dihydrodiol	172-187	glutathione S-transferase pi 1	Homo sapiens	74-80
18992797-3	2008	We investigated whether expression of human glutathione S-transferase P1 (hGSTP1) would differentially protect cells against the cytotoxicity or mutagenicity of 5MC or its 1,2-dihydrodiol intermediate (5MC-1,2-diol) in V79MZ cells with activation via stably transfected human CYP1B1 (hCYP1B1) as compared to activation by human CYP1A1 (hCYP1A1).	5mc-1,2-diol	202-214	glutathione S-transferase pi 1	Homo sapiens	44-72
18992797-5	2008	Cells co-expressing either hCYP1B1 or hCYP1A1 together with hGSTP1 were 2-fold less sensitive to 5MC or 5MC-1,2-diol cytotoxicity than their CYP-only parent lines.	5-methylchrysene	97-100	glutathione S-transferase pi 1	Homo sapiens	60-66
18992797-5	2008	Cells co-expressing either hCYP1B1 or hCYP1A1 together with hGSTP1 were 2-fold less sensitive to 5MC or 5MC-1,2-diol cytotoxicity than their CYP-only parent lines.	5mc-1,2-diol	104-116	glutathione S-transferase pi 1	Homo sapiens	60-66
18992797-7	2008	Coexpression of hGSTP1 with either hCYP reduced 5MC or 5MC-1,2-diol mutagenicity by 1.4-4.5-fold compared to the corresponding hCYP-only expressing cell lines.	5-methylchrysene	48-51	glutathione S-transferase pi 1	Homo sapiens	16-22
18992797-7	2008	Coexpression of hGSTP1 with either hCYP reduced 5MC or 5MC-1,2-diol mutagenicity by 1.4-4.5-fold compared to the corresponding hCYP-only expressing cell lines.	5mc-1,2-diol	55-67	glutathione S-transferase pi 1	Homo sapiens	16-22
18992797-8	2008	The greater protection against mutagenicity of 5MC is in contrast to our previous studies in which we found greater protection by hGSTP1 against cytotoxicity than mutagenicity of benzo[a]pyrene in cells co-expressing hCYP1A1.	5-methylchrysene	47-50	glutathione S-transferase pi 1	Homo sapiens	130-136
18992797-10	2008	These studies show that the relative efficacy of protection by hGSTP1 against mutagenicity of 5MC or 5MC-1,2-diol is in part determined by the specific CYP pathway that catalyzes activation to the toxic or mutagenic metabolites.	5-methylchrysene	94-97	glutathione S-transferase pi 1	Homo sapiens	63-69
18992797-10	2008	These studies show that the relative efficacy of protection by hGSTP1 against mutagenicity of 5MC or 5MC-1,2-diol is in part determined by the specific CYP pathway that catalyzes activation to the toxic or mutagenic metabolites.	5mc-1,2-diol	101-113	glutathione S-transferase pi 1	Homo sapiens	63-69
18784359-8	2008	In addition, we found that alcohol drinkers with the EPHX1 rs3738047 GA + AA genotypes and non-alcohol drinkers with the GSTP1 rs1695 AA genotype tended to be more susceptible to benzene toxicity.	Benzene	179-186	glutathione S-transferase pi 1	Homo sapiens	121-126
19098406-0	2008	[Single nucleotide polymorphism analysis in the GSTP1 and ABCC2 genes about neuropathy by the Oxaliplatin].	Oxaliplatin	94-105	glutathione S-transferase pi 1	Homo sapiens	48-53
19098406-11	2008	As for a successful rate of the treatment, the wild type and hetero type of GSTP1, a metabolism enzyme of Oxaliplatin, were 53.3% and 41.7%, respectively.	Oxaliplatin	106-117	glutathione S-transferase pi 1	Homo sapiens	76-81
18594869-11	2008	Our results indicate that among children with steroid-sensitive NS, there is an association with response to IVCP therapy and combination of GSTP1 Val105 polymorphism and the null genotypes of GSTT1 and GSTM1.	Steroids	46-53	glutathione S-transferase pi 1	Homo sapiens	141-146
18676679-8	2008	Selenite treatment reduced levels of DNMT1 and methylated H3-Lys 9 associated with the GSTP1 promoter, but increased levels of acetylated H3-Lys 9 associated with this promoter.	Selenious Acid	0-8	glutathione S-transferase pi 1	Homo sapiens	87-92
19057715-2	2008	We hypothesized that genetic variability in glutathione S-transferase (GST) genes (GSTP1, GSTM1, and GSTT1) could influence the effects of prenatal exposure to p,p"-DDT.	DDT	160-168	glutathione S-transferase pi 1	Homo sapiens	83-88
19057715-6	2008	RESULTS: p,p"-DDT cord serum concentration was inversely associated with general cognitive, memory, quantitative, and verbal skills, as well as executive function and working memory, in children who had any GSTP1 Val-105 allele.	DDT	14-17	glutathione S-transferase pi 1	Homo sapiens	207-212
19057715-9	2008	CONCLUSIONS: Results indicate that children with GSTP1 Val-105 allele were at higher risk of the adverse cognitive functioning effects of prenatal p,p"-DDT exposure.	DDT	147-155	glutathione S-transferase pi 1	Homo sapiens	49-54
18797455-0	2008	GSTP1 Ile105Val polymorphism correlates with progression-free survival in MCRC patients treated with or without irinotecan: a study of the Dutch Colorectal Cancer Group.	Irinotecan	112-122	glutathione S-transferase pi 1	Homo sapiens	0-5
18797455-1	2008	A Valine residue at position 105 of the GSTP1 protein results in decreased enzyme activity.	Valine	2-8	glutathione S-transferase pi 1	Homo sapiens	40-45
18797455-2	2008	As nuclear GSTP1 activity decreases irinotecan cytotoxicity, Val-allele carriers may benefit more from irinotecan chemotherapy.	Irinotecan	36-46	glutathione S-transferase pi 1	Homo sapiens	11-16
18797455-2	2008	As nuclear GSTP1 activity decreases irinotecan cytotoxicity, Val-allele carriers may benefit more from irinotecan chemotherapy.	Irinotecan	103-113	glutathione S-transferase pi 1	Homo sapiens	11-16
18797455-3	2008	Our aim was to investigate the association of GSTP1 genotype with treatment outcome of irinotecan.	Irinotecan	87-97	glutathione S-transferase pi 1	Homo sapiens	46-51
18797455-10	2008	GSTP1 codon 105 polymorphism may be predictive for the response to irinotecan-based chemotherapy in patients with MCRC, with the Val-allele being associated with a better outcome.	Irinotecan	67-77	glutathione S-transferase pi 1	Homo sapiens	0-5
19533864-8	2008	On the single oral administration, the type of polymorphisms of GSTP1 has stronger effect on VC metabolism than the form of VC, DAsA and AsA.	Dehydroascorbic Acid	128-132	glutathione S-transferase pi 1	Homo sapiens	64-69
18688861-0	2008	Thiazolides inhibit growth and induce glutathione-S-transferase Pi (GSTP1)-dependent cell death in human colon cancer cells.	thiazolides	0-11	glutathione S-transferase pi 1	Homo sapiens	68-73
18688861-6	2008	Using affinity chromatography and mass spectrometry glutathione-S-transferase P1 (GSTP1) from the GST class Pi was identified as a major thiazolide-binding protein.	thiazolide	137-147	glutathione S-transferase pi 1	Homo sapiens	52-80
18688861-6	2008	Using affinity chromatography and mass spectrometry glutathione-S-transferase P1 (GSTP1) from the GST class Pi was identified as a major thiazolide-binding protein.	thiazolide	137-147	glutathione S-transferase pi 1	Homo sapiens	82-87
18688861-6	2008	Using affinity chromatography and mass spectrometry glutathione-S-transferase P1 (GSTP1) from the GST class Pi was identified as a major thiazolide-binding protein.	thiazolide	137-147	glutathione S-transferase pi 1	Homo sapiens	98-110
18688861-7	2008	GSTP1 expression was more than 10 times higher in the thiazolide-sensitive Caco2 cells than in the less sensitive HFF cells.	thiazolide	54-64	glutathione S-transferase pi 1	Homo sapiens	0-5
18688861-7	2008	GSTP1 expression was more than 10 times higher in the thiazolide-sensitive Caco2 cells than in the less sensitive HFF cells.	caco2	75-80	glutathione S-transferase pi 1	Homo sapiens	0-5
18688861-8	2008	The enzymatic activity of recombinant GSTP1 was strongly inhibited by thiazolides.	thiazolides	70-81	glutathione S-transferase pi 1	Homo sapiens	38-43
19533864-8	2008	On the single oral administration, the type of polymorphisms of GSTP1 has stronger effect on VC metabolism than the form of VC, DAsA and AsA.	Ascorbic Acid	129-132	glutathione S-transferase pi 1	Homo sapiens	64-69
18852128-0	2008	Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin.	Cisplatin	73-82	glutathione S-transferase pi 1	Homo sapiens	8-36
18852128-1	2008	Cells expressing elevated levels of allelic variants of human glutathione S-transferase P1 (GSTP1) and/or efflux transporters, MRP1 or MRP2, were used to evaluate the role of GSTP1-1 in cisplatin resistance.	Cisplatin	186-195	glutathione S-transferase pi 1	Homo sapiens	175-182
18701490-0	2008	Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma.	Cisplatin	48-57	glutathione S-transferase pi 1	Homo sapiens	11-39
18852128-2	2008	These studies revealed that GSTP1-1 confers low-level resistance (1.4- to 1.7-fold) to cisplatin-induced cytotoxicity in MCF7 cells.	Cisplatin	87-96	glutathione S-transferase pi 1	Homo sapiens	28-35
18852128-4	2008	To understand the mechanism by which variants of GSTP1-1 confer resistance to cisplatin, their relative abilities to catalyze conjugation of cisplatin with glutathione were examined.	Cisplatin	78-87	glutathione S-transferase pi 1	Homo sapiens	49-56
18852128-4	2008	To understand the mechanism by which variants of GSTP1-1 confer resistance to cisplatin, their relative abilities to catalyze conjugation of cisplatin with glutathione were examined.	Cisplatin	141-150	glutathione S-transferase pi 1	Homo sapiens	49-56
18852128-4	2008	To understand the mechanism by which variants of GSTP1-1 confer resistance to cisplatin, their relative abilities to catalyze conjugation of cisplatin with glutathione were examined.	Glutathione	156-167	glutathione S-transferase pi 1	Homo sapiens	49-56
18852128-6	2008	Although these data are consistent with the idea that very low level resistance to cisplatin may be conferred by GSTP1-1-mediated cisplatin/glutathione conjugation, two observations indicate that such catalysis plays a minor role in the protection from cisplatin toxicity.	Cisplatin	83-92	glutathione S-transferase pi 1	Homo sapiens	113-120
18852128-6	2008	Although these data are consistent with the idea that very low level resistance to cisplatin may be conferred by GSTP1-1-mediated cisplatin/glutathione conjugation, two observations indicate that such catalysis plays a minor role in the protection from cisplatin toxicity.	Cisplatin	130-139	glutathione S-transferase pi 1	Homo sapiens	113-120
18852128-6	2008	Although these data are consistent with the idea that very low level resistance to cisplatin may be conferred by GSTP1-1-mediated cisplatin/glutathione conjugation, two observations indicate that such catalysis plays a minor role in the protection from cisplatin toxicity.	Glutathione	140-151	glutathione S-transferase pi 1	Homo sapiens	113-120
18852128-6	2008	Although these data are consistent with the idea that very low level resistance to cisplatin may be conferred by GSTP1-1-mediated cisplatin/glutathione conjugation, two observations indicate that such catalysis plays a minor role in the protection from cisplatin toxicity.	Cisplatin	130-139	glutathione S-transferase pi 1	Homo sapiens	113-120
18852128-9	2008	We conclude that high-level cisplatin resistance attributed to GSTP1-1 in other studies is not likely due to catalysis of cisplatin conjugation but rather must be explained by other mechanisms, which may include GSTP1-mediated modulation of signaling pathways.	Cisplatin	28-37	glutathione S-transferase pi 1	Homo sapiens	63-70
18852128-9	2008	We conclude that high-level cisplatin resistance attributed to GSTP1-1 in other studies is not likely due to catalysis of cisplatin conjugation but rather must be explained by other mechanisms, which may include GSTP1-mediated modulation of signaling pathways.	Cisplatin	28-37	glutathione S-transferase pi 1	Homo sapiens	63-68
18852128-9	2008	We conclude that high-level cisplatin resistance attributed to GSTP1-1 in other studies is not likely due to catalysis of cisplatin conjugation but rather must be explained by other mechanisms, which may include GSTP1-mediated modulation of signaling pathways.	Cisplatin	122-131	glutathione S-transferase pi 1	Homo sapiens	63-68
18521819-5	2008	The presence of valine alleles compared to isoleucine alleles in codon 105 in GSTP1 did not increase the risk of breast cancer development.	Isoleucine	43-53	glutathione S-transferase pi 1	Homo sapiens	78-83
18521819-7	2008	The only significant association between increased risk of breast cancer development and GSTs polymorphisms was found when GSTT1 null, GSTM1 null and the presence of valine in GSTP1 in codon 105 were combined (p < 0.048, OR = 3.75, 95% CI = 1.01-13.90).	Valine	166-172	glutathione S-transferase pi 1	Homo sapiens	176-181
18701490-2	2008	By using a series of CDDP-resistant variants, which were established from the U-2OS and Saos-2 human osteosarcoma cell lines, we found that CDDP resistance was mainly associated with the increase of both the intracellular level and enzymatic activity of glutathione S-transferase P1 (GSTP1).	Cisplatin	21-25	glutathione S-transferase pi 1	Homo sapiens	254-282
18701490-2	2008	By using a series of CDDP-resistant variants, which were established from the U-2OS and Saos-2 human osteosarcoma cell lines, we found that CDDP resistance was mainly associated with the increase of both the intracellular level and enzymatic activity of glutathione S-transferase P1 (GSTP1).	Cisplatin	21-25	glutathione S-transferase pi 1	Homo sapiens	284-289
18701490-2	2008	By using a series of CDDP-resistant variants, which were established from the U-2OS and Saos-2 human osteosarcoma cell lines, we found that CDDP resistance was mainly associated with the increase of both the intracellular level and enzymatic activity of glutathione S-transferase P1 (GSTP1).	Cisplatin	140-144	glutathione S-transferase pi 1	Homo sapiens	254-282
18701490-2	2008	By using a series of CDDP-resistant variants, which were established from the U-2OS and Saos-2 human osteosarcoma cell lines, we found that CDDP resistance was mainly associated with the increase of both the intracellular level and enzymatic activity of glutathione S-transferase P1 (GSTP1).	Cisplatin	140-144	glutathione S-transferase pi 1	Homo sapiens	284-289
18701490-4	2008	These indications prompted us to assess the in vitro effectiveness of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX), a promising new anticancer agent that is a highly efficient inhibitor of GSTP1.	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	70-117	glutathione S-transferase pi 1	Homo sapiens	201-206
18701490-8	2008	In conclusion, our findings show that GSTP1 has a relevant effect for both CDDP resistance and clinical outcome of high-grade osteosarcoma and that targeting GSTP1 with NBDHEX may be considered a promising new therapeutic possibility for osteosarcoma patients who fail to respond to conventional chemotherapy.	Cisplatin	75-79	glutathione S-transferase pi 1	Homo sapiens	38-43
18797154-8	2008	(5) Evaluation of the association between C metabolism and the single nucleotide polymorphisms of glutathione S-transferase P (GSTP) 1-1 showed a lower urinary C excretion and a significantly lower C level in 24-h urine (p<0.05) after AsA loading, and a significantly lower urinary C excretion between 0 and 3 h after DAsA loading (p<0.05) for the GA heterozygotes than for the AA homozygotes.	Aspirin	238-241	glutathione S-transferase pi 1	Homo sapiens	98-136
18636161-3	2008	Overexpression of GST P1-1 in HepG2 cells decreased both the Bcl-xL deamidation and caspase-3 activation induced by treatment with GSH-DXR.	Glutathione	131-134	glutathione S-transferase pi 1	Homo sapiens	18-26
18797154-8	2008	(5) Evaluation of the association between C metabolism and the single nucleotide polymorphisms of glutathione S-transferase P (GSTP) 1-1 showed a lower urinary C excretion and a significantly lower C level in 24-h urine (p<0.05) after AsA loading, and a significantly lower urinary C excretion between 0 and 3 h after DAsA loading (p<0.05) for the GA heterozygotes than for the AA homozygotes.	diazobenzenesulfonic acid	321-325	glutathione S-transferase pi 1	Homo sapiens	98-136
18511072-2	2008	Chlorambucil has been shown to be detoxified by human glutathione transferase Pi (GST P1-1), an enzyme that is often found over-expressed in cancer tissues.	Chlorambucil	0-12	glutathione S-transferase pi 1	Homo sapiens	82-90
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Isoleucine	105-115	glutathione S-transferase pi 1	Homo sapiens	4-9
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Isoleucine	105-115	glutathione S-transferase pi 1	Homo sapiens	186-191
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Isoleucine	117-120	glutathione S-transferase pi 1	Homo sapiens	4-9
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Isoleucine	117-120	glutathione S-transferase pi 1	Homo sapiens	186-191
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Valine	125-131	glutathione S-transferase pi 1	Homo sapiens	4-9
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Valine	125-131	glutathione S-transferase pi 1	Homo sapiens	186-191
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Valine	133-136	glutathione S-transferase pi 1	Homo sapiens	4-9
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Valine	133-136	glutathione S-transferase pi 1	Homo sapiens	186-191
18641537-3	2008	In this report, the contribution of genetic polymorphisms in the glutathione-S-transferases (GST) isozymes GSTA1, GSTM1, GSTP1, and GSTT1 to the pharmacokinetics of busulfan is studied retrospectively.	Busulfan	165-173	glutathione S-transferase pi 1	Homo sapiens	121-126
17764884-9	2008	CONCLUSION: Our present study has suggested that GSTP1 protein expression, but not GSTP1 methylation status, might be associated with response to docetaxel and paclitaxel.	Docetaxel	146-155	glutathione S-transferase pi 1	Homo sapiens	49-54
17764884-9	2008	CONCLUSION: Our present study has suggested that GSTP1 protein expression, but not GSTP1 methylation status, might be associated with response to docetaxel and paclitaxel.	Paclitaxel	160-170	glutathione S-transferase pi 1	Homo sapiens	49-54
17764884-10	2008	This suggests that GSTP1 immunohistochemical expression might be a potentially clinically useful predictive factor for response to docetaxel and paclitaxel.	Docetaxel	131-140	glutathione S-transferase pi 1	Homo sapiens	19-24
17764884-10	2008	This suggests that GSTP1 immunohistochemical expression might be a potentially clinically useful predictive factor for response to docetaxel and paclitaxel.	Paclitaxel	145-155	glutathione S-transferase pi 1	Homo sapiens	19-24
18633248-0	2008	[Impact of single nucleotide polymorphisms in glutathione S transferase gene GSTP1 in the treatment with oxaliplatin based chemotherapy].	Oxaliplatin	105-116	glutathione S-transferase pi 1	Homo sapiens	77-82
18633248-5	2008	Specific roles for the single nucleotide polymorphisms in GST-pi gene GSTP1 in the treatment with oxaliplatin based chemotherapy, have been demonstrated in recent years.	Oxaliplatin	98-109	glutathione S-transferase pi 1	Homo sapiens	70-75
18500686-9	2008	The expression pattern of GSTP1 and four other genes, ABCG2 (xenobiotic transport), CRABP2 (retinoic acid signaling), GATA3 (lineage-specific transcription), and SLPI (immune response), was confirmed by immunohistochemistry.	Tretinoin	92-105	glutathione S-transferase pi 1	Homo sapiens	26-31
17764884-0	2008	Association of GSTP1 expression with resistance to docetaxel and paclitaxel in human breast cancers.	Docetaxel	51-60	glutathione S-transferase pi 1	Homo sapiens	15-20
17764884-0	2008	Association of GSTP1 expression with resistance to docetaxel and paclitaxel in human breast cancers.	Paclitaxel	65-75	glutathione S-transferase pi 1	Homo sapiens	15-20
17764884-1	2008	AIMS: It has been reported that glutathione S-transferase P1 (GSTP1) expression is implicated in resistance to taxanes (docetaxel and paclitaxel) in human breast cancer cells in vitro.	Taxoids	111-118	glutathione S-transferase pi 1	Homo sapiens	32-60
17764884-1	2008	AIMS: It has been reported that glutathione S-transferase P1 (GSTP1) expression is implicated in resistance to taxanes (docetaxel and paclitaxel) in human breast cancer cells in vitro.	Taxoids	111-118	glutathione S-transferase pi 1	Homo sapiens	62-67
17764884-1	2008	AIMS: It has been reported that glutathione S-transferase P1 (GSTP1) expression is implicated in resistance to taxanes (docetaxel and paclitaxel) in human breast cancer cells in vitro.	Docetaxel	120-129	glutathione S-transferase pi 1	Homo sapiens	32-60
17764884-1	2008	AIMS: It has been reported that glutathione S-transferase P1 (GSTP1) expression is implicated in resistance to taxanes (docetaxel and paclitaxel) in human breast cancer cells in vitro.	Docetaxel	120-129	glutathione S-transferase pi 1	Homo sapiens	62-67
17764884-1	2008	AIMS: It has been reported that glutathione S-transferase P1 (GSTP1) expression is implicated in resistance to taxanes (docetaxel and paclitaxel) in human breast cancer cells in vitro.	Paclitaxel	134-144	glutathione S-transferase pi 1	Homo sapiens	32-60
17764884-1	2008	AIMS: It has been reported that glutathione S-transferase P1 (GSTP1) expression is implicated in resistance to taxanes (docetaxel and paclitaxel) in human breast cancer cells in vitro.	Paclitaxel	134-144	glutathione S-transferase pi 1	Homo sapiens	62-67
17764884-2	2008	In the study presented here, we examine whether GSTP1 expression is associated with resistance to docetaxel or paclitaxel in human breast cancers.	Docetaxel	98-107	glutathione S-transferase pi 1	Homo sapiens	48-53
17764884-2	2008	In the study presented here, we examine whether GSTP1 expression is associated with resistance to docetaxel or paclitaxel in human breast cancers.	Paclitaxel	111-121	glutathione S-transferase pi 1	Homo sapiens	48-53
17764884-3	2008	We also investigated the relationship between GSTP1 methylation status and response to these taxanes.	Taxoids	93-100	glutathione S-transferase pi 1	Homo sapiens	46-51
17764884-7	2008	The subset analysis showed that the mean reduction rate was significantly (p=0.005) higher in GSTP1 negative (0.59+/-0.06) than GSTP1 positive (0.11+/-0.13) tumors in the docetaxel group as well as in the paclitaxel group (p=0.006; GSTP1 negative tumors: 0.84+/-0.05; GSTP1 positive tumors: 0.56+/-0.08).	Docetaxel	171-180	glutathione S-transferase pi 1	Homo sapiens	94-99
17764884-7	2008	The subset analysis showed that the mean reduction rate was significantly (p=0.005) higher in GSTP1 negative (0.59+/-0.06) than GSTP1 positive (0.11+/-0.13) tumors in the docetaxel group as well as in the paclitaxel group (p=0.006; GSTP1 negative tumors: 0.84+/-0.05; GSTP1 positive tumors: 0.56+/-0.08).	Docetaxel	171-180	glutathione S-transferase pi 1	Homo sapiens	128-133
17764884-7	2008	The subset analysis showed that the mean reduction rate was significantly (p=0.005) higher in GSTP1 negative (0.59+/-0.06) than GSTP1 positive (0.11+/-0.13) tumors in the docetaxel group as well as in the paclitaxel group (p=0.006; GSTP1 negative tumors: 0.84+/-0.05; GSTP1 positive tumors: 0.56+/-0.08).	Docetaxel	171-180	glutathione S-transferase pi 1	Homo sapiens	128-133
17764884-7	2008	The subset analysis showed that the mean reduction rate was significantly (p=0.005) higher in GSTP1 negative (0.59+/-0.06) than GSTP1 positive (0.11+/-0.13) tumors in the docetaxel group as well as in the paclitaxel group (p=0.006; GSTP1 negative tumors: 0.84+/-0.05; GSTP1 positive tumors: 0.56+/-0.08).	Docetaxel	171-180	glutathione S-transferase pi 1	Homo sapiens	128-133
17764884-7	2008	The subset analysis showed that the mean reduction rate was significantly (p=0.005) higher in GSTP1 negative (0.59+/-0.06) than GSTP1 positive (0.11+/-0.13) tumors in the docetaxel group as well as in the paclitaxel group (p=0.006; GSTP1 negative tumors: 0.84+/-0.05; GSTP1 positive tumors: 0.56+/-0.08).	Paclitaxel	205-215	glutathione S-transferase pi 1	Homo sapiens	94-99
18511072-3	2008	The allelic variants of GST P1-1 are associated with differing susceptibilities to leukaemia and differ markedly in their efficiency in catalysing glutathione (GSH) conjugation reactions.	Glutathione	147-158	glutathione S-transferase pi 1	Homo sapiens	24-32
18511072-3	2008	The allelic variants of GST P1-1 are associated with differing susceptibilities to leukaemia and differ markedly in their efficiency in catalysing glutathione (GSH) conjugation reactions.	Glutathione	160-163	glutathione S-transferase pi 1	Homo sapiens	24-32
18511072-6	2008	We show also that all variants exhibit the same temperature stability in the range 10 degrees C to 45 degrees C. We have determined the crystal structures of GST P1-1 in complex with chlorambucil and its GSH conjugate for two of these allelic variants that have different residues at positions 104 and 113.	Chlorambucil	183-195	glutathione S-transferase pi 1	Homo sapiens	158-166
18511072-6	2008	We show also that all variants exhibit the same temperature stability in the range 10 degrees C to 45 degrees C. We have determined the crystal structures of GST P1-1 in complex with chlorambucil and its GSH conjugate for two of these allelic variants that have different residues at positions 104 and 113.	Glutathione	204-207	glutathione S-transferase pi 1	Homo sapiens	158-166
18511072-8	2008	This result suggests that under certain stress conditions where GSH levels are low, GST P1-1 can inactivate the drug by sequestering it from the surrounding medium.	Glutathione	64-67	glutathione S-transferase pi 1	Homo sapiens	84-92
17912498-0	2008	Sulfotransferase 1A1 and glutathione S-transferase P1 genetic polymorphisms modulate the levels of urinary 8-hydroxy-2"-deoxyguanosine in betel quid chewers.	8-ohdg	107-134	glutathione S-transferase pi 1	Homo sapiens	25-53
17912498-12	2008	Chewers with both of SULT1A1 Arg-Arg and GSTP1 Val-Val/Ile-Val (4.6 ng/mg creatinine), and non-chewers with either SULT1A1 Arg-His or GSTP1 Ile-Ile (4.7 ng/mg creatinine) had a moderately increased 8-OHdG level.	Valine	47-50	glutathione S-transferase pi 1	Homo sapiens	41-46
17912498-4	2008	Safrole may be metabolized by hepatic sulfotransferase 1A1 (SULT1A1), or glutathione S-transferases (GSTM1, GSTT1, and GSTP1).	Safrole	0-7	glutathione S-transferase pi 1	Homo sapiens	119-124
17912498-9	2008	Urinary 8-OHdG level was also higher in chewers with GSTP1 Ile-Ile genotype.	8-ohdg	8-14	glutathione S-transferase pi 1	Homo sapiens	53-58
17912498-11	2008	Non-chewers with both SULT1A1 Arg-Arg and GSTP1 Val-Val/Ile-Val (reference group) had the lowest mean level (3.6 ng/mg creatinine), whereas chewers with either SULT1A1 Arg-His or GSTP1 Ile-Ile had the highest 8-OHdG mean level (6.2 ng/mg creatinine; vs. reference group, P = 0.04).	Valine	48-51	glutathione S-transferase pi 1	Homo sapiens	42-47
17912498-11	2008	Non-chewers with both SULT1A1 Arg-Arg and GSTP1 Val-Val/Ile-Val (reference group) had the lowest mean level (3.6 ng/mg creatinine), whereas chewers with either SULT1A1 Arg-His or GSTP1 Ile-Ile had the highest 8-OHdG mean level (6.2 ng/mg creatinine; vs. reference group, P = 0.04).	Valine	52-55	glutathione S-transferase pi 1	Homo sapiens	42-47
17912498-11	2008	Non-chewers with both SULT1A1 Arg-Arg and GSTP1 Val-Val/Ile-Val (reference group) had the lowest mean level (3.6 ng/mg creatinine), whereas chewers with either SULT1A1 Arg-His or GSTP1 Ile-Ile had the highest 8-OHdG mean level (6.2 ng/mg creatinine; vs. reference group, P = 0.04).	Valine	52-55	glutathione S-transferase pi 1	Homo sapiens	42-47
17912498-11	2008	Non-chewers with both SULT1A1 Arg-Arg and GSTP1 Val-Val/Ile-Val (reference group) had the lowest mean level (3.6 ng/mg creatinine), whereas chewers with either SULT1A1 Arg-His or GSTP1 Ile-Ile had the highest 8-OHdG mean level (6.2 ng/mg creatinine; vs. reference group, P = 0.04).	Creatinine	119-129	glutathione S-transferase pi 1	Homo sapiens	42-47
18425393-6	2008	A notable trend was also found in Caucasian women with a history of smoking and at least one valine allele at GSTP1 114 (OR=2.12; 95% CI=1.02-4.41).	Valine	93-99	glutathione S-transferase pi 1	Homo sapiens	110-115
17875191-0	2008	Serious haematological toxicity of cyclophosphamide in relation to CYP2B6, GSTA1 and GSTP1 polymorphisms.	Cyclophosphamide	35-51	glutathione S-transferase pi 1	Homo sapiens	85-90
18204073-0	2008	Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane.	isothiocyanic acid	106-120	glutathione S-transferase pi 1	Homo sapiens	23-30
18204073-0	2008	Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane.	sulforaphane	122-134	glutathione S-transferase pi 1	Homo sapiens	23-30
18204073-2	2008	Because SFN is a reactive electrophile--readily forming conjugates with glutathione (GSH)--we asked whether expression of glutathione S-transferase (GST) P1-1 and the GSH conjugate efflux pump, multidrug resistance or resistance-associated protein (MRP) 1, would significantly modify the cellular response to SFN exposure.	sulforaphane	8-11	glutathione S-transferase pi 1	Homo sapiens	122-158
17892615-0	2008	Association between GSTP1 gene polymorphism and serum alpha-GST concentrations undergoing sevoflurane anaesthesia.	Sevoflurane	90-101	glutathione S-transferase pi 1	Homo sapiens	20-25
17892615-3	2008	The aim of the study was to assess whether an association exists between glutathione-S-transferase P1 gene polymorphism and serum alpha-glutathione-S-transferase concentrations for the first postoperative day in patients who underwent anaesthesia with sevoflurane.	Sevoflurane	252-263	glutathione S-transferase pi 1	Homo sapiens	73-101
18177897-0	2008	Modulating catalytic activity by unnatural amino acid residues in a GSH-binding loop of GST P1-1.	Glutathione	68-71	glutathione S-transferase pi 1	Homo sapiens	88-96
18204073-4	2008	Compared with parental cells, expression of GSTP1-1 alone enhanced the rate of intracellular accumulation of SFN and its glutathione conjugate, SFN-SG--an effect that was associated with increased ARE-containing reporter gene induction.	sulforaphane	109-112	glutathione S-transferase pi 1	Homo sapiens	44-51
18204073-4	2008	Compared with parental cells, expression of GSTP1-1 alone enhanced the rate of intracellular accumulation of SFN and its glutathione conjugate, SFN-SG--an effect that was associated with increased ARE-containing reporter gene induction.	Glutathione	121-132	glutathione S-transferase pi 1	Homo sapiens	44-51
18204073-7	2008	Depletion of GSH prior to SFN treatment or the substitution of tert-butylhydroquinone for SFN abolished the effects of MRP1/GSTP1-1 on ARE-containing gene induction-indicating that these effects are GSH dependent.	Glutathione	13-16	glutathione S-transferase pi 1	Homo sapiens	124-131
18204073-7	2008	Depletion of GSH prior to SFN treatment or the substitution of tert-butylhydroquinone for SFN abolished the effects of MRP1/GSTP1-1 on ARE-containing gene induction-indicating that these effects are GSH dependent.	2-tert-butylhydroquinone	63-85	glutathione S-transferase pi 1	Homo sapiens	124-131
18204073-7	2008	Depletion of GSH prior to SFN treatment or the substitution of tert-butylhydroquinone for SFN abolished the effects of MRP1/GSTP1-1 on ARE-containing gene induction-indicating that these effects are GSH dependent.	sulforaphane	90-93	glutathione S-transferase pi 1	Homo sapiens	124-131
18204073-7	2008	Depletion of GSH prior to SFN treatment or the substitution of tert-butylhydroquinone for SFN abolished the effects of MRP1/GSTP1-1 on ARE-containing gene induction-indicating that these effects are GSH dependent.	Glutathione	199-202	glutathione S-transferase pi 1	Homo sapiens	124-131
18326615-1	2008	BACKGROUND: Cruciferous vegetables are the primary source of isothiocyanates and other glucosinolate derivatives that are known to induce phase II detoxifying enzymes, including glutathione S-transferases (GSTs).	Isothiocyanates	61-76	glutathione S-transferase pi 1	Homo sapiens	206-210
18326615-1	2008	BACKGROUND: Cruciferous vegetables are the primary source of isothiocyanates and other glucosinolate derivatives that are known to induce phase II detoxifying enzymes, including glutathione S-transferases (GSTs).	Glucosinolates	87-100	glutathione S-transferase pi 1	Homo sapiens	206-210
18178302-5	2008	Moreover, VOC and/or PAH coated onto PM induced gene expression of cytochrome P450 (cyp) 1a1, cyp2e1, nadph quinone oxydo-reductase-1, and glutathione S-transferase-pi 1 and mu 3, versus controls, suggesting thereby the formation of biologically reactive metabolites.	Polycyclic Aromatic Hydrocarbons	21-24	glutathione S-transferase pi 1	Homo sapiens	139-178
18181168-3	2008	We find using methylation specific PCR (MSP) that a low, nontoxic concentration of genistein (3.125 microM, resupplemented every 48 hr for 1 week) or a single dose of lycopene (2 microM) partially demethylates the promoter of the GSTP1 tumor suppressor gene in MDA-MB-468 cells.	Genistein	83-92	glutathione S-transferase pi 1	Homo sapiens	230-235
18383821-0	2008	Identification of glutathione sulfotransferase-pi (GSTP1) as a new resveratrol targeting protein (RTP) and studies of resveratrol-responsive protein changes by resveratrol affinity chromatography.	Resveratrol	67-78	glutathione S-transferase pi 1	Homo sapiens	51-56
18383821-6	2008	CONCLUSION: Resveratrol affects cellular functions at multiple levels, ranging from interaction with detoxification enzymes, such as GSTP1 and transcription by targeting factors such as ER-beta.	Resveratrol	12-23	glutathione S-transferase pi 1	Homo sapiens	133-138
17676332-3	2008	RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship.	Isoleucine	30-40	glutathione S-transferase pi 1	Homo sapiens	18-23
17676332-3	2008	RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship.	Isoleucine	41-51	glutathione S-transferase pi 1	Homo sapiens	18-23
17676332-3	2008	RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship.	Alanine	68-75	glutathione S-transferase pi 1	Homo sapiens	56-61
17676332-3	2008	RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship.	Alanine	68-75	glutathione S-transferase pi 1	Homo sapiens	56-61
17676332-3	2008	RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship.	Alanine	76-83	glutathione S-transferase pi 1	Homo sapiens	56-61
17676332-3	2008	RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship.	Alanine	76-83	glutathione S-transferase pi 1	Homo sapiens	56-61
17676332-3	2008	RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship.	u-mdx	118-123	glutathione S-transferase pi 1	Homo sapiens	18-23
17676332-3	2008	RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship.	u-mdx	118-123	glutathione S-transferase pi 1	Homo sapiens	56-61
17676332-3	2008	RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship.	u-mdx	118-123	glutathione S-transferase pi 1	Homo sapiens	56-61
17676332-4	2008	GSTP1 (105) isoleucine/isoleucine was found to be associated with lower levels of S-IgG-MDI and fewer eye symptoms, but with an increased risk of symptoms in the airways, as well as with atopy.	Isoleucine	12-22	glutathione S-transferase pi 1	Homo sapiens	0-5
18540691-13	2008	Patients carrying the Val/Val genotype in the GSTP1 gene had a lower risk of haematological toxicity (odds ratio = 0.322, 95% CI 0.101, 0.957) than patients with the Ile/Ile genotype.	Valine	22-25	glutathione S-transferase pi 1	Homo sapiens	46-51
18540691-13	2008	Patients carrying the Val/Val genotype in the GSTP1 gene had a lower risk of haematological toxicity (odds ratio = 0.322, 95% CI 0.101, 0.957) than patients with the Ile/Ile genotype.	Valine	26-29	glutathione S-transferase pi 1	Homo sapiens	46-51
18569587-10	2008	After implementation of the SNP into the model significant lower adjusted means of urinary PGA concentrations were found for GSTP1 105IleVal and CYP2E1 -71TT.	Folic Acid	91-94	glutathione S-transferase pi 1	Homo sapiens	125-130
18776599-9	2008	MDR analysis revealed a three-gene combination, consisting of NOS3 (p.Glu298Asp), GSTZ1 (p.Lys32Glu), and GSTP1 (p.Ile105Val), that provided the highest predictive model for GM-induced vestibular dysfunction (64% accuracy; p=0.009).	Gentamicins	174-176	glutathione S-transferase pi 1	Homo sapiens	106-111
18569592-1	2008	The genotype glutathione S-transferase P1 (GSTP1) influences the risk for bladder cancer among Chinese workers occupationally exposed to benzidine.	benzidine	137-146	glutathione S-transferase pi 1	Homo sapiens	13-41
17512053-1	2008	This study examines the response to dexamethasone-doxorubicin-vincristine (DAV) therapy, followed by conditioning regimen and autologous stem cells transplantation (ASCT) in patients with multiple myeloma in relation with the presence of polymorphisms in genes involved in drug metabolism (GSTP1) and DNA synthesis (TYMS).	Dexamethasone	36-49	glutathione S-transferase pi 1	Homo sapiens	290-295
17512053-1	2008	This study examines the response to dexamethasone-doxorubicin-vincristine (DAV) therapy, followed by conditioning regimen and autologous stem cells transplantation (ASCT) in patients with multiple myeloma in relation with the presence of polymorphisms in genes involved in drug metabolism (GSTP1) and DNA synthesis (TYMS).	VAD I protocol	75-78	glutathione S-transferase pi 1	Homo sapiens	290-295
18569592-1	2008	The genotype glutathione S-transferase P1 (GSTP1) influences the risk for bladder cancer among Chinese workers occupationally exposed to benzidine.	benzidine	137-146	glutathione S-transferase pi 1	Homo sapiens	43-48
18569592-3	2008	Research was thus conducted to define the role of GSTP1 genotypes in Caucasian bladder cancer cases with an occupational history of exposure to aromatic amines.	aromatic amines	144-159	glutathione S-transferase pi 1	Homo sapiens	50-55
18203258-3	2008	Here, human GST pi (GSTP) was exploited as a model target protein to determine the chemical, biochemical and functional consequences of exposure to the hepatotoxic CRM of paracetamol (APAP), N-acetyl-p-benzoquinoneimine (NAPQI).	Acetaminophen	171-182	glutathione S-transferase pi 1	Homo sapiens	12-18
18203258-3	2008	Here, human GST pi (GSTP) was exploited as a model target protein to determine the chemical, biochemical and functional consequences of exposure to the hepatotoxic CRM of paracetamol (APAP), N-acetyl-p-benzoquinoneimine (NAPQI).	Acetaminophen	171-182	glutathione S-transferase pi 1	Homo sapiens	20-24
18203258-3	2008	Here, human GST pi (GSTP) was exploited as a model target protein to determine the chemical, biochemical and functional consequences of exposure to the hepatotoxic CRM of paracetamol (APAP), N-acetyl-p-benzoquinoneimine (NAPQI).	Acetaminophen	184-188	glutathione S-transferase pi 1	Homo sapiens	12-18
18203258-3	2008	Here, human GST pi (GSTP) was exploited as a model target protein to determine the chemical, biochemical and functional consequences of exposure to the hepatotoxic CRM of paracetamol (APAP), N-acetyl-p-benzoquinoneimine (NAPQI).	Acetaminophen	184-188	glutathione S-transferase pi 1	Homo sapiens	20-24
18203258-3	2008	Here, human GST pi (GSTP) was exploited as a model target protein to determine the chemical, biochemical and functional consequences of exposure to the hepatotoxic CRM of paracetamol (APAP), N-acetyl-p-benzoquinoneimine (NAPQI).	N-acetyl-4-benzoquinoneimine	191-219	glutathione S-transferase pi 1	Homo sapiens	12-18
18203258-3	2008	Here, human GST pi (GSTP) was exploited as a model target protein to determine the chemical, biochemical and functional consequences of exposure to the hepatotoxic CRM of paracetamol (APAP), N-acetyl-p-benzoquinoneimine (NAPQI).	N-acetyl-4-benzoquinoneimine	191-219	glutathione S-transferase pi 1	Homo sapiens	20-24
18203258-3	2008	Here, human GST pi (GSTP) was exploited as a model target protein to determine the chemical, biochemical and functional consequences of exposure to the hepatotoxic CRM of paracetamol (APAP), N-acetyl-p-benzoquinoneimine (NAPQI).	N-acetyl-4-benzoquinoneimine	221-226	glutathione S-transferase pi 1	Homo sapiens	12-18
18203258-3	2008	Here, human GST pi (GSTP) was exploited as a model target protein to determine the chemical, biochemical and functional consequences of exposure to the hepatotoxic CRM of paracetamol (APAP), N-acetyl-p-benzoquinoneimine (NAPQI).	N-acetyl-4-benzoquinoneimine	221-226	glutathione S-transferase pi 1	Homo sapiens	20-24
18203258-4	2008	Site-specific, dose-dependent modification of Cys47 in native and His-tagged GSTP was revealed by MS, and correlated with inhibition of glutathione (GSH) conjugating activity.	Histidine	66-69	glutathione S-transferase pi 1	Homo sapiens	77-81
18203258-4	2008	Site-specific, dose-dependent modification of Cys47 in native and His-tagged GSTP was revealed by MS, and correlated with inhibition of glutathione (GSH) conjugating activity.	Glutathione	136-147	glutathione S-transferase pi 1	Homo sapiens	77-81
18203258-4	2008	Site-specific, dose-dependent modification of Cys47 in native and His-tagged GSTP was revealed by MS, and correlated with inhibition of glutathione (GSH) conjugating activity.	Glutathione	149-152	glutathione S-transferase pi 1	Homo sapiens	77-81
19077407-10	2008	GSTP1 expression was decreased in combined treatment with doxazosin and finasteride.	Doxazosin	58-67	glutathione S-transferase pi 1	Homo sapiens	0-5
18162130-9	2007	Hypothetically, absence of GST-M1 leaves more glutathione as substrate for the co-expressed GST-P1.	Glutathione	46-57	glutathione S-transferase pi 1	Homo sapiens	92-98
17964545-0	2007	Polymorphism of glutathione S-transferase P1 gene affects human vitamin C metabolism.	Ascorbic Acid	64-73	glutathione S-transferase pi 1	Homo sapiens	16-44
17964545-3	2007	Thus, the effects of polymorphism A313G (Ile105Val) in the gene for glutathione S-transferases P1 (GSTP1), one of the most active xenobiotic enzymes, on human VC metabolism were studied.	ile105val	41-50	glutathione S-transferase pi 1	Homo sapiens	68-97
17964545-3	2007	Thus, the effects of polymorphism A313G (Ile105Val) in the gene for glutathione S-transferases P1 (GSTP1), one of the most active xenobiotic enzymes, on human VC metabolism were studied.	ile105val	41-50	glutathione S-transferase pi 1	Homo sapiens	99-104
17964545-4	2007	The variant frequency of GSTP1 among the present subjects (n=210) was AA 71.0%; GA 27.0% and GG 1.9%.	Gallium	80-82	glutathione S-transferase pi 1	Homo sapiens	25-30
19077407-10	2008	GSTP1 expression was decreased in combined treatment with doxazosin and finasteride.	Finasteride	72-83	glutathione S-transferase pi 1	Homo sapiens	0-5
17918761-2	2007	Enzyme kinetics and electrospray mass spectrometry experiments using GST P1-1 and its cysteine-modified mutant forms revealed that the complexes are effective enzyme inhibitors, but they also rapidly inactivate the enzyme by covalent binding at Cys 47 and, to a lesser extent, Cys 101.	Cysteine	86-94	glutathione S-transferase pi 1	Homo sapiens	69-77
17975885-10	2007	Given that GSTM1a-1a and GSTP1-1 are present in the intestinal epithelial cells, it can be concluded that efficient glutathione conjugation of curcumin may already occur in the enterocytes, followed by an efficient excretion of these glutathione conjugates to the lumen, thereby reducing the bioavailability of (unconjugated) curcumin.	Curcumin	143-151	glutathione S-transferase pi 1	Homo sapiens	25-32
17975885-11	2007	In conclusion, the present study identifies the nature of the diastereoisomeric monoglutathionyl curcumin conjugates, CURSG-1 and CURSG-2 formed in biological systems, and reveals that conjugate formation is catalyzed by GSTM1a-1a, GSTA1-1, and/or GSTP1-1 with different stereoselective preference.	Curcumin	97-105	glutathione S-transferase pi 1	Homo sapiens	248-255
17918761-2	2007	Enzyme kinetics and electrospray mass spectrometry experiments using GST P1-1 and its cysteine-modified mutant forms revealed that the complexes are effective enzyme inhibitors, but they also rapidly inactivate the enzyme by covalent binding at Cys 47 and, to a lesser extent, Cys 101.	Cysteine	245-248	glutathione S-transferase pi 1	Homo sapiens	69-77
17918761-2	2007	Enzyme kinetics and electrospray mass spectrometry experiments using GST P1-1 and its cysteine-modified mutant forms revealed that the complexes are effective enzyme inhibitors, but they also rapidly inactivate the enzyme by covalent binding at Cys 47 and, to a lesser extent, Cys 101.	Cysteine	277-280	glutathione S-transferase pi 1	Homo sapiens	69-77
18072598-1	2007	Aberrant gene silencing of genes through cytosine methylation has been demonstrated during the development of many types of cancers including prostate cancer Several genes including GSTP1 have been shown to be methylated in prostate cancer leading to the suggestion and demonstration that methylation status of such genes could be used as cancer diagnosis markers alone or in support of histology.	Cytosine	41-49	glutathione S-transferase pi 1	Homo sapiens	182-187
18085999-1	2007	INTRODUCTION: Glutathione S-transferase P1 (GSTP1) and excision-repair cross-complementing repair deficiency group 2 protein (ERCC2 or XPD) may modulate the activity of platinum derivatives.	Platinum	169-177	glutathione S-transferase pi 1	Homo sapiens	14-42
18085999-1	2007	INTRODUCTION: Glutathione S-transferase P1 (GSTP1) and excision-repair cross-complementing repair deficiency group 2 protein (ERCC2 or XPD) may modulate the activity of platinum derivatives.	Platinum	169-177	glutathione S-transferase pi 1	Homo sapiens	44-49
18085999-2	2007	The SNPs, Ile105Val for GSTP1 and Lys751Gln for ERCC2, may affect the efficiency of oxaliplatin in patients treated with an oxaliplatin-based regimen for metastatic colorectal carcinoma.	ile105val	10-19	glutathione S-transferase pi 1	Homo sapiens	24-29
18085999-2	2007	The SNPs, Ile105Val for GSTP1 and Lys751Gln for ERCC2, may affect the efficiency of oxaliplatin in patients treated with an oxaliplatin-based regimen for metastatic colorectal carcinoma.	Oxaliplatin	84-95	glutathione S-transferase pi 1	Homo sapiens	24-29
18085999-2	2007	The SNPs, Ile105Val for GSTP1 and Lys751Gln for ERCC2, may affect the efficiency of oxaliplatin in patients treated with an oxaliplatin-based regimen for metastatic colorectal carcinoma.	Oxaliplatin	124-135	glutathione S-transferase pi 1	Homo sapiens	24-29
18085999-4	2007	GSTP1 and ERCC2 genotypes were identified on DNA samples extracted from paraffin blocks containing either normal tissue (nodes) or tumor tissue.	Paraffin	72-80	glutathione S-transferase pi 1	Homo sapiens	0-5
18085999-6	2007	RESULTS: GSTP1 genotype distribution was Ile/Ile 58%, Ile/Val 35% and Val/Val 7%.	Isoleucine	41-44	glutathione S-transferase pi 1	Homo sapiens	9-14
18085999-6	2007	RESULTS: GSTP1 genotype distribution was Ile/Ile 58%, Ile/Val 35% and Val/Val 7%.	Isoleucine	45-48	glutathione S-transferase pi 1	Homo sapiens	9-14
18085999-6	2007	RESULTS: GSTP1 genotype distribution was Ile/Ile 58%, Ile/Val 35% and Val/Val 7%.	Valine	58-61	glutathione S-transferase pi 1	Homo sapiens	9-14
18085999-6	2007	RESULTS: GSTP1 genotype distribution was Ile/Ile 58%, Ile/Val 35% and Val/Val 7%.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	9-14
18085999-6	2007	RESULTS: GSTP1 genotype distribution was Ile/Ile 58%, Ile/Val 35% and Val/Val 7%.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	9-14
17823364-10	2007	Glutathione S-transferase P1 (GST-P1) was identified as one major target regulated by H2O2.	Hydrogen Peroxide	86-90	glutathione S-transferase pi 1	Homo sapiens	0-28
17823364-10	2007	Glutathione S-transferase P1 (GST-P1) was identified as one major target regulated by H2O2.	Hydrogen Peroxide	86-90	glutathione S-transferase pi 1	Homo sapiens	30-36
17823364-11	2007	siRNA against GST-P1 abolished the antiapoptotic effect of H2O2.	Hydrogen Peroxide	59-63	glutathione S-transferase pi 1	Homo sapiens	14-20
17652311-3	2007	The aim of the present study was to determine whether polymorphisms in antioxidant enzyme (GSTM1, GSTP1 and NQO1) genes affect the risk of lung function changes related to chronic exposure to O(3).	Ozone	192-196	glutathione S-transferase pi 1	Homo sapiens	98-103
17961182-5	2007	Treatment of proliferating VSMCs with butyrate leads to the induction of several GSTs.	Butyrates	38-46	glutathione S-transferase pi 1	Homo sapiens	81-85
17961182-7	2007	Also, the butyrate-induced antiproliferative action, and the induction of GST-P1 and its nuclear localization are downregulated when butyrate is withdrawn.	Butyrates	10-18	glutathione S-transferase pi 1	Homo sapiens	74-80
17961182-7	2007	Also, the butyrate-induced antiproliferative action, and the induction of GST-P1 and its nuclear localization are downregulated when butyrate is withdrawn.	Butyrates	133-141	glutathione S-transferase pi 1	Homo sapiens	74-80
17961182-10	2007	Collectively, the butyrate-treatment-related increase in glutathione content, the reduction in reactive oxygen species, the upregulation of GST and the nuclear localization of GST-P1 in growth-arrested VSMCs imply that butyrate"s antiproliferative action involves modulation of the cellular redox state.	Butyrates	18-26	glutathione S-transferase pi 1	Homo sapiens	176-182
17961182-10	2007	Collectively, the butyrate-treatment-related increase in glutathione content, the reduction in reactive oxygen species, the upregulation of GST and the nuclear localization of GST-P1 in growth-arrested VSMCs imply that butyrate"s antiproliferative action involves modulation of the cellular redox state.	Butyrates	219-227	glutathione S-transferase pi 1	Homo sapiens	176-182
17587159-1	2007	The bacterial expression and purification of human glutathione S-transferase P1-1(hGST P1-1), as a hexahistidine-tagged polypeptide was performed.	His-His-His-His-His-His	99-112	glutathione S-transferase pi 1	Homo sapiens	82-91
17415778-4	2007	We find that in noncancerous prostate cells (RWPE-1 and PWR-1E) GSTP1 is constitutively expressed, not methylated, highly accessible, bound by transcription factors and associated with histones with activating modifications (histone H3 methylated at lysine 4 and acetylated histones H3 and H4).	Lysine	250-256	glutathione S-transferase pi 1	Homo sapiens	64-69
17415778-7	2007	Treatment of LNCaP cells with 5-azacytidine restores activating histone modifications on GSTP1 and reactivates transcription.	Azacitidine	30-43	glutathione S-transferase pi 1	Homo sapiens	89-94
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Histidine	125-128	glutathione S-transferase pi 1	Homo sapiens	114-123
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Histidine	125-128	glutathione S-transferase pi 1	Homo sapiens	132-141
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Water	161-166	glutathione S-transferase pi 1	Homo sapiens	114-123
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Histidine	231-234	glutathione S-transferase pi 1	Homo sapiens	114-123
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Sodium Dodecyl Sulfate	13-16	glutathione S-transferase pi 1	Homo sapiens	114-123
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Sodium Dodecyl Sulfate	13-16	glutathione S-transferase pi 1	Homo sapiens	132-141
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	polyacrylamide	17-31	glutathione S-transferase pi 1	Homo sapiens	114-123
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Sodium Dodecyl Sulfate	53-56	glutathione S-transferase pi 1	Homo sapiens	114-123
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	Sodium Dodecyl Sulfate	53-56	glutathione S-transferase pi 1	Homo sapiens	132-141
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	His-His-His-His-His-His	93-106	glutathione S-transferase pi 1	Homo sapiens	114-123
17587159-4	2007	Moreover, on SDS-polyacrylamide gel electrophoresis (SDS-PAGE) under nonreducing conditions, hexahistidine-tagged hGST P1-1 (His(6)-hGST P1-1) treated with 1 mM H(2)O(2) showed at least three extra bands, in addition to the native His(6)-hGST P1-1 subunit band.	His-His-His-His-His-His	93-106	glutathione S-transferase pi 1	Homo sapiens	132-141
16973168-4	2007	The high-arsenic exposure group with GSTP1 variant genotypes of Ile/Val and Val/Val, and with the p53 variant genotypes of Arg/Pro and Pro/Pro had 6.0- and 3.1-fold higher risks of carotid atherosclerosis, respectively.	Arsenic	9-16	glutathione S-transferase pi 1	Homo sapiens	37-42
17953352-6	2007	CONCLUSION: CDP has the ability to reactivate the hypermethylated GSTP1 gene promoter activity.	Cytidine Diphosphate	12-15	glutathione S-transferase pi 1	Homo sapiens	66-71
17560037-2	2007	We report here the identification and characterisation of a novel naturally occurring transition that changes codon 169 from GGC (Gly) to GAC (Asp) in the human Pi class GST, GSTP1.	Glycine	130-133	glutathione S-transferase pi 1	Homo sapiens	175-180
17560037-2	2007	We report here the identification and characterisation of a novel naturally occurring transition that changes codon 169 from GGC (Gly) to GAC (Asp) in the human Pi class GST, GSTP1.	DIHYDRO-ACARBOSE	138-141	glutathione S-transferase pi 1	Homo sapiens	175-180
17560037-2	2007	We report here the identification and characterisation of a novel naturally occurring transition that changes codon 169 from GGC (Gly) to GAC (Asp) in the human Pi class GST, GSTP1.	Aspartic Acid	143-146	glutathione S-transferase pi 1	Homo sapiens	175-180
17716224-7	2007	Among patients the GSTP1 mutated allele was more frequent in those drinking more than 50 g ethanol/day (odds ratio: 2.00; 95% confidence intervals: 1.06-3.78).	Ethanol	91-98	glutathione S-transferase pi 1	Homo sapiens	19-24
17498780-7	2007	These results showed that AhR, UGT1A1, GSTP1 and GSTT1 polymorphisms were associated with urinary 1-OHP concentrations in Chinese coke oven workers.	Oxaliplatin	98-103	glutathione S-transferase pi 1	Homo sapiens	39-44
17431793-0	2007	Conformational change in the active center region of GST P1-1, due to binding of a synthetic conjugate of DXR with GSH, enhanced JNK-mediated apoptosis.	Glutathione	115-118	glutathione S-transferase pi 1	Homo sapiens	53-61
17431793-3	2007	In the present experiment, binding of GSH-DXR to GST P1-1 allosterically led to the disappearance of its enzyme activity and activated the kinase activity of JNK without dissociation of the JNK-GST P1-1 complex.	Glutathione	38-41	glutathione S-transferase pi 1	Homo sapiens	49-57
17431793-3	2007	In the present experiment, binding of GSH-DXR to GST P1-1 allosterically led to the disappearance of its enzyme activity and activated the kinase activity of JNK without dissociation of the JNK-GST P1-1 complex.	Glutathione	38-41	glutathione S-transferase pi 1	Homo sapiens	49-55
17431793-8	2007	The findings suggested that allosteric inhibition of GST P1-1 activity by the binding of GSH-DXR following conformational change may activate JNK and induce apoptosis via the mitochondrial pathway in the cells.	Glutathione	89-92	glutathione S-transferase pi 1	Homo sapiens	53-61
17551301-7	2007	For stage II/III patients, to have 2 or 3 polymorphisms of 3R/3R of 5"-TSER, a 6 bp of 3"-TSUTR, and GSTP1-Ile105Val resulted in an extensively longer survival (P = 0.020), although no difference was found between 2 groups, with respect to the plasma concentrations of 5-FU and clinicopathologic characteristics.	Fluorouracil	269-273	glutathione S-transferase pi 1	Homo sapiens	101-106
16973168-5	2007	In addition, the high-arsenic exposure group with one or two variant genotypes of GSTP1 and p53 had 2.8- and 6.1-fold higher risks of carotid atherosclerosis, respectively, and showed a dose-dependent relationship.	Arsenic	22-29	glutathione S-transferase pi 1	Homo sapiens	82-87
16973168-7	2007	Our study showed the joint effects on the risk of carotid atherosclerosis between the genetic polymorphisms of GSTP1 and p53, and arsenic exposure.	Arsenic	130-137	glutathione S-transferase pi 1	Homo sapiens	111-116
17699792-8	2007	RG19, a subclone of Raji cells stably transfected with a GSTpi expression vector, and K562 cells with high endogenous GSTP1-1 activity were less sensitive to EABE-induced apoptosis.	ethacrynic acid butyl ester	158-162	glutathione S-transferase pi 1	Homo sapiens	118-125
17508213-1	2007	Glutathione-S-transferase P1 (GSTP1) and O6-methylguanine DNA methyltransferase (MGMT) are involved in drug-resistant to chemotherapeutic agents such as doxorubicin.	Doxorubicin	153-164	glutathione S-transferase pi 1	Homo sapiens	0-28
17508213-1	2007	Glutathione-S-transferase P1 (GSTP1) and O6-methylguanine DNA methyltransferase (MGMT) are involved in drug-resistant to chemotherapeutic agents such as doxorubicin.	Doxorubicin	153-164	glutathione S-transferase pi 1	Homo sapiens	30-35
17267100-7	2007	Expression of GSTP1 correlated significantly with GSH level and gamma-GCS and GR activities.	Glutathione	50-53	glutathione S-transferase pi 1	Homo sapiens	14-19
18409811-4	2007	In particular, 1,2-dichlorobenzene (DCB), ethylbenzene (ETB), cumene, Sulphotep and 2-eptanone (2-EPT) behaved as inhibitors of the purified GSTP1-1 enzyme, with different inhibition properties according to molecular structure.	2-dichlorobenzene	15-34	glutathione S-transferase pi 1	Homo sapiens	141-148
18409811-4	2007	In particular, 1,2-dichlorobenzene (DCB), ethylbenzene (ETB), cumene, Sulphotep and 2-eptanone (2-EPT) behaved as inhibitors of the purified GSTP1-1 enzyme, with different inhibition properties according to molecular structure.	ethylbenzene	42-54	glutathione S-transferase pi 1	Homo sapiens	141-148
18409811-4	2007	In particular, 1,2-dichlorobenzene (DCB), ethylbenzene (ETB), cumene, Sulphotep and 2-eptanone (2-EPT) behaved as inhibitors of the purified GSTP1-1 enzyme, with different inhibition properties according to molecular structure.	ethylbenzene	56-59	glutathione S-transferase pi 1	Homo sapiens	141-148
18409811-4	2007	In particular, 1,2-dichlorobenzene (DCB), ethylbenzene (ETB), cumene, Sulphotep and 2-eptanone (2-EPT) behaved as inhibitors of the purified GSTP1-1 enzyme, with different inhibition properties according to molecular structure.	cumene	62-68	glutathione S-transferase pi 1	Homo sapiens	141-148
18409811-4	2007	In particular, 1,2-dichlorobenzene (DCB), ethylbenzene (ETB), cumene, Sulphotep and 2-eptanone (2-EPT) behaved as inhibitors of the purified GSTP1-1 enzyme, with different inhibition properties according to molecular structure.	sulphotep	70-79	glutathione S-transferase pi 1	Homo sapiens	141-148
18409811-4	2007	In particular, 1,2-dichlorobenzene (DCB), ethylbenzene (ETB), cumene, Sulphotep and 2-eptanone (2-EPT) behaved as inhibitors of the purified GSTP1-1 enzyme, with different inhibition properties according to molecular structure.	2-eptanone	84-94	glutathione S-transferase pi 1	Homo sapiens	141-148
18409811-4	2007	In particular, 1,2-dichlorobenzene (DCB), ethylbenzene (ETB), cumene, Sulphotep and 2-eptanone (2-EPT) behaved as inhibitors of the purified GSTP1-1 enzyme, with different inhibition properties according to molecular structure.	2-ept	96-101	glutathione S-transferase pi 1	Homo sapiens	141-148
18409811-9	2007	In particular, cumene and DCB triggered a clear increase of the intracellular GSTP1-1 activity at concentrations lower than 0.1mM.	cumene	15-21	glutathione S-transferase pi 1	Homo sapiens	78-85
18409811-9	2007	In particular, cumene and DCB triggered a clear increase of the intracellular GSTP1-1 activity at concentrations lower than 0.1mM.	2-dichlorobenzene	26-29	glutathione S-transferase pi 1	Homo sapiens	78-85
17548691-5	2007	After adjusting for smoking status, carrying the putative "high-risk" genotype combination, the faster metabolism of PAH-epoxides to PAH-diol-epoxides (CYP1B1 432Val/Val and mEH 139Arg/Arg) with lower PAH-diol-epoxide conjugation (GSTP1 (105)Ile/Ile), was associated with increased adducts only in Caucasian nontumor cells (0.2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05).	pah-epoxides	117-129	glutathione S-transferase pi 1	Homo sapiens	231-236
17548691-5	2007	After adjusting for smoking status, carrying the putative "high-risk" genotype combination, the faster metabolism of PAH-epoxides to PAH-diol-epoxides (CYP1B1 432Val/Val and mEH 139Arg/Arg) with lower PAH-diol-epoxide conjugation (GSTP1 (105)Ile/Ile), was associated with increased adducts only in Caucasian nontumor cells (0.2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05).	pah-diol-epoxides	133-150	glutathione S-transferase pi 1	Homo sapiens	231-236
17548691-5	2007	After adjusting for smoking status, carrying the putative "high-risk" genotype combination, the faster metabolism of PAH-epoxides to PAH-diol-epoxides (CYP1B1 432Val/Val and mEH 139Arg/Arg) with lower PAH-diol-epoxide conjugation (GSTP1 (105)Ile/Ile), was associated with increased adducts only in Caucasian nontumor cells (0.2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05).	Arginine	181-184	glutathione S-transferase pi 1	Homo sapiens	231-236
17548691-5	2007	After adjusting for smoking status, carrying the putative "high-risk" genotype combination, the faster metabolism of PAH-epoxides to PAH-diol-epoxides (CYP1B1 432Val/Val and mEH 139Arg/Arg) with lower PAH-diol-epoxide conjugation (GSTP1 (105)Ile/Ile), was associated with increased adducts only in Caucasian nontumor cells (0.2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05).	Polycyclic Aromatic Hydrocarbons	117-120	glutathione S-transferase pi 1	Homo sapiens	231-236
17548691-5	2007	After adjusting for smoking status, carrying the putative "high-risk" genotype combination, the faster metabolism of PAH-epoxides to PAH-diol-epoxides (CYP1B1 432Val/Val and mEH 139Arg/Arg) with lower PAH-diol-epoxide conjugation (GSTP1 (105)Ile/Ile), was associated with increased adducts only in Caucasian nontumor cells (0.2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05).	diol	137-141	glutathione S-transferase pi 1	Homo sapiens	231-236
17548691-5	2007	After adjusting for smoking status, carrying the putative "high-risk" genotype combination, the faster metabolism of PAH-epoxides to PAH-diol-epoxides (CYP1B1 432Val/Val and mEH 139Arg/Arg) with lower PAH-diol-epoxide conjugation (GSTP1 (105)Ile/Ile), was associated with increased adducts only in Caucasian nontumor cells (0.2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05).	Epoxy Compounds	121-128	glutathione S-transferase pi 1	Homo sapiens	231-236
17449203-0	2007	Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element.	Curcumin	0-8	glutathione S-transferase pi 1	Homo sapiens	25-53
17584018-0	2007	GSTP1 and MTHFR polymorphisms are related with toxicity in breast cancer adjuvant anthracycline-based treatment.	Anthracyclines	82-95	glutathione S-transferase pi 1	Homo sapiens	0-5
17584018-6	2007	Our results suggest that GSTP1 and MTHFR genotypes may be consider relevant and independent factors of toxicity in adjuvant anthracycline-based treatment of breast cancer.	Anthracyclines	124-137	glutathione S-transferase pi 1	Homo sapiens	25-30
17479284-5	2007	GSTP1 promoter hypermethylation was detected in 4/24 (16.7%) of UDH, 18/49 (36.7%) of DCIS, and 14/36 (38.9%) of IDC.	6-AMINOHEXYL-URIDINE-C1,5'-DIPHOSPHATE	64-67	glutathione S-transferase pi 1	Homo sapiens	0-5
17593093-1	2007	AIM: Glutathione-S-transferase P1 (GSTP1) detoxifies a wide range of endogenous and exogenous carcinogens and anticancer agents such as cisplatin and doxorubicin.	Cisplatin	136-145	glutathione S-transferase pi 1	Homo sapiens	5-33
17593093-1	2007	AIM: Glutathione-S-transferase P1 (GSTP1) detoxifies a wide range of endogenous and exogenous carcinogens and anticancer agents such as cisplatin and doxorubicin.	Cisplatin	136-145	glutathione S-transferase pi 1	Homo sapiens	35-40
17593093-1	2007	AIM: Glutathione-S-transferase P1 (GSTP1) detoxifies a wide range of endogenous and exogenous carcinogens and anticancer agents such as cisplatin and doxorubicin.	Doxorubicin	150-161	glutathione S-transferase pi 1	Homo sapiens	5-33
17593093-1	2007	AIM: Glutathione-S-transferase P1 (GSTP1) detoxifies a wide range of endogenous and exogenous carcinogens and anticancer agents such as cisplatin and doxorubicin.	Doxorubicin	150-161	glutathione S-transferase pi 1	Homo sapiens	35-40
17593093-2	2007	The aim of this study was to examine the association between GSTP1 polymorphism and both urothelial cancer susceptibility and adverse events of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) chemotherapy in Japanese urothelial cancer patients.	M-VAC protocol	144-149	glutathione S-transferase pi 1	Homo sapiens	61-66
17593093-2	2007	The aim of this study was to examine the association between GSTP1 polymorphism and both urothelial cancer susceptibility and adverse events of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) chemotherapy in Japanese urothelial cancer patients.	Methotrexate	151-163	glutathione S-transferase pi 1	Homo sapiens	61-66
17593093-2	2007	The aim of this study was to examine the association between GSTP1 polymorphism and both urothelial cancer susceptibility and adverse events of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) chemotherapy in Japanese urothelial cancer patients.	Vinblastine	165-176	glutathione S-transferase pi 1	Homo sapiens	61-66
17593093-2	2007	The aim of this study was to examine the association between GSTP1 polymorphism and both urothelial cancer susceptibility and adverse events of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) chemotherapy in Japanese urothelial cancer patients.	Doxorubicin	178-189	glutathione S-transferase pi 1	Homo sapiens	61-66
17593093-2	2007	The aim of this study was to examine the association between GSTP1 polymorphism and both urothelial cancer susceptibility and adverse events of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) chemotherapy in Japanese urothelial cancer patients.	Cisplatin	194-203	glutathione S-transferase pi 1	Homo sapiens	61-66
17449203-4	2007	In this study, we demonstrated that curcumin could induce the expression of human glutathione S-transferase P1 (GSTP1).	Curcumin	36-44	glutathione S-transferase pi 1	Homo sapiens	82-110
17449203-4	2007	In this study, we demonstrated that curcumin could induce the expression of human glutathione S-transferase P1 (GSTP1).	Curcumin	36-44	glutathione S-transferase pi 1	Homo sapiens	112-117
17449203-5	2007	In HepG2 cells treated with 20muM curcumin, the level of GSTP1 mRNA was significantly increased.	Curcumin	34-42	glutathione S-transferase pi 1	Homo sapiens	57-62
17449203-10	2007	In a gel mobility shift assay with an oligonucleotide with GSTP1 ARE, an increase in the amount of the binding complex was observed in the nuclear extracts of curcumin-treated HepG2 cells.	Oligonucleotides	38-53	glutathione S-transferase pi 1	Homo sapiens	59-64
17449203-10	2007	In a gel mobility shift assay with an oligonucleotide with GSTP1 ARE, an increase in the amount of the binding complex was observed in the nuclear extracts of curcumin-treated HepG2 cells.	Curcumin	159-167	glutathione S-transferase pi 1	Homo sapiens	59-64
17449203-11	2007	These results suggested that ARE is the primary sequence for the curcumin-induced transactivation of the GSTP1 gene.	Curcumin	65-73	glutathione S-transferase pi 1	Homo sapiens	105-110
17449203-12	2007	The induction of GSTP1 may be one of the mechanisms underlying the multiple actions of curcumin.	Curcumin	87-95	glutathione S-transferase pi 1	Homo sapiens	17-22
17513610-9	2007	The cytotoxicity assay also showed that GSTP1 suppression caused a 2.5-fold increase in cell growth inhibition resulting from doxorubicin and cisplatin treatments [the IC(50)s are approximately 0.16 micromol/L (doxorubicin) and 1.8 micromol/L (cisplatin) for parental HOS versus 0.06 micromol/L (doxorubicin) and 0.75 micromol/L (cisplatin) for GSTP1-silenced HOS].	Doxorubicin	126-137	glutathione S-transferase pi 1	Homo sapiens	345-350
17513610-9	2007	The cytotoxicity assay also showed that GSTP1 suppression caused a 2.5-fold increase in cell growth inhibition resulting from doxorubicin and cisplatin treatments [the IC(50)s are approximately 0.16 micromol/L (doxorubicin) and 1.8 micromol/L (cisplatin) for parental HOS versus 0.06 micromol/L (doxorubicin) and 0.75 micromol/L (cisplatin) for GSTP1-silenced HOS].	Cisplatin	142-151	glutathione S-transferase pi 1	Homo sapiens	40-45
17513610-6	2007	Our results showed that GSTP1 expression was up-regulated in osteosarcoma cells when they were treated with doxorubicin or cisplatin.	Doxorubicin	108-119	glutathione S-transferase pi 1	Homo sapiens	24-29
17513610-6	2007	Our results showed that GSTP1 expression was up-regulated in osteosarcoma cells when they were treated with doxorubicin or cisplatin.	Cisplatin	123-132	glutathione S-transferase pi 1	Homo sapiens	24-29
17513610-9	2007	The cytotoxicity assay also showed that GSTP1 suppression caused a 2.5-fold increase in cell growth inhibition resulting from doxorubicin and cisplatin treatments [the IC(50)s are approximately 0.16 micromol/L (doxorubicin) and 1.8 micromol/L (cisplatin) for parental HOS versus 0.06 micromol/L (doxorubicin) and 0.75 micromol/L (cisplatin) for GSTP1-silenced HOS].	Cisplatin	142-151	glutathione S-transferase pi 1	Homo sapiens	345-350
17513610-7	2007	GSTP1 overexpression in SAOS-2 osteosarcoma cells caused the cells to be more resistant to doxorubicin and cisplatin.	Doxorubicin	91-102	glutathione S-transferase pi 1	Homo sapiens	0-5
17513610-9	2007	The cytotoxicity assay also showed that GSTP1 suppression caused a 2.5-fold increase in cell growth inhibition resulting from doxorubicin and cisplatin treatments [the IC(50)s are approximately 0.16 micromol/L (doxorubicin) and 1.8 micromol/L (cisplatin) for parental HOS versus 0.06 micromol/L (doxorubicin) and 0.75 micromol/L (cisplatin) for GSTP1-silenced HOS].	Doxorubicin	211-222	glutathione S-transferase pi 1	Homo sapiens	40-45
17513610-7	2007	GSTP1 overexpression in SAOS-2 osteosarcoma cells caused the cells to be more resistant to doxorubicin and cisplatin.	Cisplatin	107-116	glutathione S-transferase pi 1	Homo sapiens	0-5
17513610-9	2007	The cytotoxicity assay also showed that GSTP1 suppression caused a 2.5-fold increase in cell growth inhibition resulting from doxorubicin and cisplatin treatments [the IC(50)s are approximately 0.16 micromol/L (doxorubicin) and 1.8 micromol/L (cisplatin) for parental HOS versus 0.06 micromol/L (doxorubicin) and 0.75 micromol/L (cisplatin) for GSTP1-silenced HOS].	Cisplatin	244-253	glutathione S-transferase pi 1	Homo sapiens	40-45
17513610-8	2007	In contrast, GSTP1 suppression in HOS cells caused more apoptosis and extensive DNA damage in response to doxorubicin and cisplatin.	Doxorubicin	106-117	glutathione S-transferase pi 1	Homo sapiens	13-18
17513610-8	2007	In contrast, GSTP1 suppression in HOS cells caused more apoptosis and extensive DNA damage in response to doxorubicin and cisplatin.	Cisplatin	122-131	glutathione S-transferase pi 1	Homo sapiens	13-18
17513610-9	2007	The cytotoxicity assay also showed that GSTP1 suppression caused a 2.5-fold increase in cell growth inhibition resulting from doxorubicin and cisplatin treatments [the IC(50)s are approximately 0.16 micromol/L (doxorubicin) and 1.8 micromol/L (cisplatin) for parental HOS versus 0.06 micromol/L (doxorubicin) and 0.75 micromol/L (cisplatin) for GSTP1-silenced HOS].	Doxorubicin	211-222	glutathione S-transferase pi 1	Homo sapiens	40-45
17513610-9	2007	The cytotoxicity assay also showed that GSTP1 suppression caused a 2.5-fold increase in cell growth inhibition resulting from doxorubicin and cisplatin treatments [the IC(50)s are approximately 0.16 micromol/L (doxorubicin) and 1.8 micromol/L (cisplatin) for parental HOS versus 0.06 micromol/L (doxorubicin) and 0.75 micromol/L (cisplatin) for GSTP1-silenced HOS].	Doxorubicin	126-137	glutathione S-transferase pi 1	Homo sapiens	40-45
17513610-9	2007	The cytotoxicity assay also showed that GSTP1 suppression caused a 2.5-fold increase in cell growth inhibition resulting from doxorubicin and cisplatin treatments [the IC(50)s are approximately 0.16 micromol/L (doxorubicin) and 1.8 micromol/L (cisplatin) for parental HOS versus 0.06 micromol/L (doxorubicin) and 0.75 micromol/L (cisplatin) for GSTP1-silenced HOS].	Cisplatin	244-253	glutathione S-transferase pi 1	Homo sapiens	40-45
17513610-10	2007	Moreover, GSTP1 suppression decreased the activation of extracellular signal-regulated kinase 1/2, which is induced by cisplatin and doxorubicin.	Cisplatin	119-128	glutathione S-transferase pi 1	Homo sapiens	10-15
17513610-10	2007	Moreover, GSTP1 suppression decreased the activation of extracellular signal-regulated kinase 1/2, which is induced by cisplatin and doxorubicin.	Doxorubicin	133-144	glutathione S-transferase pi 1	Homo sapiens	10-15
17513610-11	2007	Taken together, these findings show that GSTP1 contributes to doxorubicin and cisplatin resistance in osteosarcoma, which may be mediated in part by the activation of extracellular signal-regulated kinase 1/2.	Doxorubicin	62-73	glutathione S-transferase pi 1	Homo sapiens	41-46
17513610-11	2007	Taken together, these findings show that GSTP1 contributes to doxorubicin and cisplatin resistance in osteosarcoma, which may be mediated in part by the activation of extracellular signal-regulated kinase 1/2.	Cisplatin	78-87	glutathione S-transferase pi 1	Homo sapiens	41-46
17322540-1	2007	BACKGROUND: The aim of this study was to determine whether expressions of the excision repair cross-complementing (ERCC1), thymidylate synthase (TS), and glutathione S-transferase P1 (GSTP1) predict clinical outcome in patients with advanced gastric cancer treated with fluorouracil (5-fluorouracil)/oxaliplatin chemotherapy.	Fluorouracil	284-298	glutathione S-transferase pi 1	Homo sapiens	184-189
17696749-3	2007	Polymorphisms of GSTP1 at codon 105 residue forms GSTP1 active site for binding of hydrophobic electrophiles, and the Ile-Val substitution affect substrate specific catalytic activity of this enzyme and may associate with susceptibility to malignant human disease, especially acute lymphoblastic leukemia (ALL), which is the most common leukemia in children younger than 15 years old.	isoleucylvaline	118-125	glutathione S-transferase pi 1	Homo sapiens	17-22
17379858-5	2007	For ethacrynic acid with the GST P1 EAD system, IC(50) values of 6.0 +/- 2.9 and 3.6 +/- 2.8 microM were obtained in FIA and HPLC modes, respectively.	Ethacrynic Acid	4-19	glutathione S-transferase pi 1	Homo sapiens	29-35
17322540-0	2007	Prognostic value of expression of ERCC1, thymidylate synthase, and glutathione S-transferase P1 for 5-fluorouracil/oxaliplatin chemotherapy in advanced gastric cancer.	Fluorouracil	100-114	glutathione S-transferase pi 1	Homo sapiens	67-95
17322540-0	2007	Prognostic value of expression of ERCC1, thymidylate synthase, and glutathione S-transferase P1 for 5-fluorouracil/oxaliplatin chemotherapy in advanced gastric cancer.	Oxaliplatin	115-126	glutathione S-transferase pi 1	Homo sapiens	67-95
17322540-1	2007	BACKGROUND: The aim of this study was to determine whether expressions of the excision repair cross-complementing (ERCC1), thymidylate synthase (TS), and glutathione S-transferase P1 (GSTP1) predict clinical outcome in patients with advanced gastric cancer treated with fluorouracil (5-fluorouracil)/oxaliplatin chemotherapy.	Fluorouracil	270-282	glutathione S-transferase pi 1	Homo sapiens	184-189
17287120-1	2007	Ethacrynic acid (EA), an alpha,beta-unsaturated carbonyl compound, is a glutathione S-transferase P1-1 (GSTP1-1) inhibitor.	Ethacrynic Acid	0-15	glutathione S-transferase pi 1	Homo sapiens	104-111
17287120-1	2007	Ethacrynic acid (EA), an alpha,beta-unsaturated carbonyl compound, is a glutathione S-transferase P1-1 (GSTP1-1) inhibitor.	Ethacrynic Acid	17-19	glutathione S-transferase pi 1	Homo sapiens	104-111
17287120-4	2007	Compounds with a halogen substitution at the 3"-position of the aromatic ring have greater inhibitory effects on GSTP1-1 activity than those of compounds with a methyl substitution there.	Halogens	17-24	glutathione S-transferase pi 1	Homo sapiens	113-120
17322540-1	2007	BACKGROUND: The aim of this study was to determine whether expressions of the excision repair cross-complementing (ERCC1), thymidylate synthase (TS), and glutathione S-transferase P1 (GSTP1) predict clinical outcome in patients with advanced gastric cancer treated with fluorouracil (5-fluorouracil)/oxaliplatin chemotherapy.	Oxaliplatin	300-311	glutathione S-transferase pi 1	Homo sapiens	184-189
17169324-3	2007	Here we show that the cyPG 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) binds to GSTP1-1 covalently, as demonstrated by mass spectrometry and by the use of biotinylated 15d-PGJ2.	-deoxy-delta	29-41	glutathione S-transferase pi 1	Homo sapiens	74-81
17065199-7	2007	Exposure to genistein significantly increased hGSTP1 mRNA (2.3-fold), hGSTP1-1 protein levels (3.1-fold), GST catalytic activity (4.7-fold) and intracellular glutathione concentrations (1.4-fold) in MCF-10A cells, whereas no effects were observed on GST expression or glutathione concentrations in MCF-7 cells.	Genistein	12-21	glutathione S-transferase pi 1	Homo sapiens	46-52
17065199-7	2007	Exposure to genistein significantly increased hGSTP1 mRNA (2.3-fold), hGSTP1-1 protein levels (3.1-fold), GST catalytic activity (4.7-fold) and intracellular glutathione concentrations (1.4-fold) in MCF-10A cells, whereas no effects were observed on GST expression or glutathione concentrations in MCF-7 cells.	Genistein	12-21	glutathione S-transferase pi 1	Homo sapiens	70-78
17228018-11	2007	CONCLUSION: The presence of both alleles of 105Val-GSTP1 offered protection against cisplatin-induced hearing impairment.	Cisplatin	84-93	glutathione S-transferase pi 1	Homo sapiens	51-56
17265526-9	2007	In a survival analysis of 138 patients who received 5-flurorouracil, patients who carried the GSTP1*C containing genotype had a significantly longer survival than patients who carried the non-*C genotype (multivariate hazard ratio, 0.45; 95% CI, 0.22-0.94).	5-flurorouracil	52-67	glutathione S-transferase pi 1	Homo sapiens	94-99
17265526-10	2007	CONCLUSIONS: The GSTP1*C variant conferred a possible protective effect against pancreatic cancer in older individuals and a significant survival advantage in patients who received 5-florouracil.	Fluorouracil	181-194	glutathione S-transferase pi 1	Homo sapiens	17-22
17169324-3	2007	Here we show that the cyPG 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) binds to GSTP1-1 covalently, as demonstrated by mass spectrometry and by the use of biotinylated 15d-PGJ2.	9-deoxy-delta-9-prostaglandin D2	49-53	glutathione S-transferase pi 1	Homo sapiens	74-81
17169324-3	2007	Here we show that the cyPG 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) binds to GSTP1-1 covalently, as demonstrated by mass spectrometry and by the use of biotinylated 15d-PGJ2.	15-deoxy-delta(12,14)-prostaglandin J2	55-63	glutathione S-transferase pi 1	Homo sapiens	74-81
17169324-6	2007	Covalent interactions also occur in cells, in which 15d-PGJ2 binds to endogenous GSTP1-1, irreversibly reduces GST free-thiol content and inhibits GST activity.	15-deoxy-delta(12,14)-prostaglandin J2	52-60	glutathione S-transferase pi 1	Homo sapiens	81-88
17169324-6	2007	Covalent interactions also occur in cells, in which 15d-PGJ2 binds to endogenous GSTP1-1, irreversibly reduces GST free-thiol content and inhibits GST activity.	Sulfhydryl Compounds	120-125	glutathione S-transferase pi 1	Homo sapiens	81-88
18607078-5	2007	The hGSTP1-1 showed very high specific activity toward atrazine.	Atrazine	55-63	glutathione S-transferase pi 1	Homo sapiens	4-12
16885195-10	2007	These results indicate that the reduction in hCYP1A1-mediated B[a]P mutagenesis by hGSTP1 is probably largely due to prevention of the N2-guanine-BPDE adduct.	n2-guanine-bpde	135-150	glutathione S-transferase pi 1	Homo sapiens	83-89
17195228-7	2007	Homozygosity for GSTM1-null and GSTP1 Ile105Val in combination was associated with earlier SLE diagnosis (P = 0.03), but there was no association with proximity to 416 hazardous sites.	ile105val	38-47	glutathione S-transferase pi 1	Homo sapiens	32-37
16885195-0	2007	Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1.	Benzo(a)pyrene	71-85	glutathione S-transferase pi 1	Homo sapiens	20-48
17965617-5	2007	We validated DHPLC as a methylation screening tool using GSTP1, a well known target of methylation in prostate cancer.	dhplc	13-18	glutathione S-transferase pi 1	Homo sapiens	57-62
16885195-0	2007	Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1.	benzo(a)pyrene 7,8-dihydrodiol	89-119	glutathione S-transferase pi 1	Homo sapiens	20-48
16885195-6	2007	Mutagenicity induced by the B[a]P 7,8-dihydrodiols was also dose-dependent, and was reduced 2- to 5-fold by hGSTP1.	7,8-dihydrodiols	34-50	glutathione S-transferase pi 1	Homo sapiens	108-114
16885195-8	2007	Nevertheless, (32)P-post-labeling analysis demonstrated nearly total prevention of the known B[a]P-DNA adduct, N2-guanine-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), in cells co-expressing hGSTP1.	n2-guanine-benzo[a]pyrene-7,8-diol-9,10-epoxide	111-158	glutathione S-transferase pi 1	Homo sapiens	190-196
17365145-5	2007	GSTP1 exon 5 genotype frequencies were Ile105Ile: 58.7%, Ile105Val: 35.3%, Val105Val: 6.0% and GSTP1 exon 6 genotype frequencies were Ala114Ala: 85.0%, Ala114Val: 14.3%, Val114Val: 0.7%.	ala114ala	134-143	glutathione S-transferase pi 1	Homo sapiens	0-5
17643058-8	2007	The association between the Ile105Val polymorphism in the GSTP1 gene and childhood asthma was significant in both groups (p = 0.047 in group 1, and p = 0.021 in group 2).	ile105val	28-37	glutathione S-transferase pi 1	Homo sapiens	58-63
17365145-5	2007	GSTP1 exon 5 genotype frequencies were Ile105Ile: 58.7%, Ile105Val: 35.3%, Val105Val: 6.0% and GSTP1 exon 6 genotype frequencies were Ala114Ala: 85.0%, Ala114Val: 14.3%, Val114Val: 0.7%.	ala114ala	134-143	glutathione S-transferase pi 1	Homo sapiens	95-100
17424838-0	2007	[Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].	Benzene	93-100	glutathione S-transferase pi 1	Homo sapiens	37-42
16921492-0	2007	Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer.	isothiocyanic acid	58-72	glutathione S-transferase pi 1	Homo sapiens	82-87
18067039-9	2007	The genotypic distribution of GSTP1 was Ile(105)/Ile(105) in 47.3%, Ile(105)/Val(105) in 30.97% and Val(105)/Val(105) in 21.74% of ESRD patients.	Isoleucine	40-43	glutathione S-transferase pi 1	Homo sapiens	30-35
18067039-9	2007	The genotypic distribution of GSTP1 was Ile(105)/Ile(105) in 47.3%, Ile(105)/Val(105) in 30.97% and Val(105)/Val(105) in 21.74% of ESRD patients.	Isoleucine	49-52	glutathione S-transferase pi 1	Homo sapiens	30-35
18067039-9	2007	The genotypic distribution of GSTP1 was Ile(105)/Ile(105) in 47.3%, Ile(105)/Val(105) in 30.97% and Val(105)/Val(105) in 21.74% of ESRD patients.	Isoleucine	49-52	glutathione S-transferase pi 1	Homo sapiens	30-35
17424838-1	2007	OBJECTIVE: To explore the relationship between genetic polymorphisms in MPO, NQO1, GSTP1, UGT1A6 and susceptibility to chronic benzene poisoning (BP).	Benzene	127-134	glutathione S-transferase pi 1	Homo sapiens	83-88
17108810-15	2006	The GSTP1 A1578G (Ile105Val) status might be a susceptibility factor for arsenic-related skin lesions.	Arsenic	73-80	glutathione S-transferase pi 1	Homo sapiens	4-9
17131458-0	2006	Intervention with polyphenol-rich fruit juices results in an elevation of glutathione S-transferase P1 (hGSTP1) protein expression in human leucocytes of healthy volunteers.	Polyphenols	18-28	glutathione S-transferase pi 1	Homo sapiens	74-102
17131458-0	2006	Intervention with polyphenol-rich fruit juices results in an elevation of glutathione S-transferase P1 (hGSTP1) protein expression in human leucocytes of healthy volunteers.	Polyphenols	18-28	glutathione S-transferase pi 1	Homo sapiens	104-110
17131458-0	2006	Intervention with polyphenol-rich fruit juices results in an elevation of glutathione S-transferase P1 (hGSTP1) protein expression in human leucocytes of healthy volunteers.	juices	40-46	glutathione S-transferase pi 1	Homo sapiens	74-102
17131458-0	2006	Intervention with polyphenol-rich fruit juices results in an elevation of glutathione S-transferase P1 (hGSTP1) protein expression in human leucocytes of healthy volunteers.	juices	40-46	glutathione S-transferase pi 1	Homo sapiens	104-110
17131458-14	2006	In vivo, however, we observed a delayed enhancement of hGSTP1, which could be associated with an initial repression of oxidative DNA damage in leucocytes from human subjects, consuming juices with high levels of polyphenols.	Polyphenols	212-223	glutathione S-transferase pi 1	Homo sapiens	55-61
17181111-2	2006	The glutathione S-transferases (GSTs) protect cells against the effects of ROS.	Reactive Oxygen Species	75-78	glutathione S-transferase pi 1	Homo sapiens	32-36
17159790-7	2006	CONCLUSIONS: Our results suggest that GSTP1*105Val allele and low EPHX1 activity genotype may be protective for people occupationally exposed to asbestos.	Asbestos	145-153	glutathione S-transferase pi 1	Homo sapiens	38-43
16894565-12	2006	This small retrospective study suggests that gene expression levels of EGFR, ERCC1 and GST-P1 may be useful in predicting the clinical outcome of patients with metastatic CRC treated with first-line CPT-11 based chemotherapy.	Irinotecan	199-205	glutathione S-transferase pi 1	Homo sapiens	87-93
17016661-7	2006	The herbal treatments also increased glutathione S-transferase-pi (GSTP1) expression, albeit to a lesser extent than MGMT.	Glutathione	37-48	glutathione S-transferase pi 1	Homo sapiens	67-72
16791478-1	2006	Glutathione S-transferase P1 (GSTP1) belongs to a family of phase II metabolic enzymes that can detoxify the carcinogens and cytotoxic drugs by conjugating them with glutathione.	Glutathione	166-177	glutathione S-transferase pi 1	Homo sapiens	0-28
16791478-1	2006	Glutathione S-transferase P1 (GSTP1) belongs to a family of phase II metabolic enzymes that can detoxify the carcinogens and cytotoxic drugs by conjugating them with glutathione.	Glutathione	166-177	glutathione S-transferase pi 1	Homo sapiens	30-35
17088135-9	2006	Children with asthma with GSTP1 val/val genotype had higher malondialdehyde and lower glutathione levels compared with other genotypes (P = .023 and P = .014, respectively).	Malondialdehyde	60-75	glutathione S-transferase pi 1	Homo sapiens	26-31
17088135-9	2006	Children with asthma with GSTP1 val/val genotype had higher malondialdehyde and lower glutathione levels compared with other genotypes (P = .023 and P = .014, respectively).	Glutathione	86-97	glutathione S-transferase pi 1	Homo sapiens	26-31
16977512-8	2006	Thus we suggest that the Val allele of GSTP1 may have a protective effect for development of COPD.	Valine	25-28	glutathione S-transferase pi 1	Homo sapiens	39-44
16338071-11	2006	However, interaction of smoking or alcohol with GSTM1 null or GSTP1 ile/ile moderately increases the risk for esophageal cancer in North Indian population.	Alcohols	35-42	glutathione S-transferase pi 1	Homo sapiens	62-67
16733740-0	2006	Role of GSTP1-1 in mediating the effect of As2O3 in the Acute Promyelocytic Leukemia cell line NB4.	Arsenic Trioxide	43-48	glutathione S-transferase pi 1	Homo sapiens	8-15
16733740-8	2006	Our results suggest that APL sensitivity to As2O3 might be, at least in part, mediated by the balance between association and dissociation of JNK from GSTP1-1, depending on the redox status of the cell.	Arsenic Trioxide	44-49	glutathione S-transferase pi 1	Homo sapiens	151-158
16933328-2	2006	The polymorphic GSTP1 gene encodes glutathione S-transferase pi, which is an enzyme that detoxifies cigarette carcinogens, such as benzo-[a]-pyrene.	Benzo(a)pyrene	131-147	glutathione S-transferase pi 1	Homo sapiens	16-21
17194031-4	2006	GSTs A1, P1 and M1 were inhibited by O6-benzylguanine (IC50s around 30 microM), GST P1-1 by sulphinpyrazone (IC50 = 66 microM), GST Al-1 by sulphasalazine, and camptothecin (34 and 74 microM respectively), and GST M1-1 by sulphasalazine, camptothecin and indomethacin (0.3, 29 and 30 microM respectively) using CDNB as a substrate.	Sulfinpyrazone	92-107	glutathione S-transferase pi 1	Homo sapiens	80-88
17194031-6	2006	However, progesterone was a potent inhibitor of GST P1-1 (IC50 = 1.4 microM) with ethacrynic acid as substrate.	Progesterone	9-21	glutathione S-transferase pi 1	Homo sapiens	48-56
17194031-6	2006	However, progesterone was a potent inhibitor of GST P1-1 (IC50 = 1.4 microM) with ethacrynic acid as substrate.	Ethacrynic Acid	82-97	glutathione S-transferase pi 1	Homo sapiens	48-56
17409936-1	2006	BACKGROUND: Polymorphisms within the P1 isoenzyme of GST (GSTP1) are associated with alterations in enzyme activity and may change sensitivity to platinum-based chemotherapy.	Platinum	146-154	glutathione S-transferase pi 1	Homo sapiens	58-63
16636664-9	2006	Moreover, the glutathione-conjugating activity of GSTP1-1 was not involved in the regulation of TRAF2 signaling.	Glutathione	14-25	glutathione S-transferase pi 1	Homo sapiens	50-57
17409936-9	2006	CONCLUSIONS: GSTP1 haplotype can be used to stratify hematological toxicity after platinum-based chemotherapy, but the lack of significant associations with response or survival suggests that GSTP1 polymorphisms may not be strong pharmacogenomic markers in this population.	Platinum	82-90	glutathione S-transferase pi 1	Homo sapiens	13-18
16814760-0	2006	Acridine Orange based platinum(II) complexes inducing cytotoxicity and cell cycle perturbation in spite of GSTP1 up-regulation.	Acridine Orange	0-15	glutathione S-transferase pi 1	Homo sapiens	107-112
16910707-8	2006	Furthermore, glutathione S-transferase P 1 and cytoskeleton-8, -18, and -19 revealed a down-regulation in a dose-dependent manner in exposure of Caco-2 cells to monacolin K.	Lovastatin	161-172	glutathione S-transferase pi 1	Homo sapiens	13-42
16675217-5	2006	Bivalent analogs of the non-selective GST inhibitor ethacrynic acid were prepared, and selectivity for the GST A1-1 isozyme over GST P1-1 (IC50 values of 13.7 vs 1022 nM, respectively) was achieved through the optimization of the spacer length between the ethacrynic acid ligand domains.	Ethacrynic Acid	52-67	glutathione S-transferase pi 1	Homo sapiens	129-137
16814760-0	2006	Acridine Orange based platinum(II) complexes inducing cytotoxicity and cell cycle perturbation in spite of GSTP1 up-regulation.	platinum(ii)	22-34	glutathione S-transferase pi 1	Homo sapiens	107-112
16814760-6	2006	The lack of resistance of the new Pt(II)-AO complexes and their cytotoxicity, cell growth and cell cycle recovery in melanoma cells provide the basis for the development of new platinum anticancer compounds, directed to those tumors that over express GSTs enzymes.	pt(ii)-ao	34-43	glutathione S-transferase pi 1	Homo sapiens	251-255
16802828-4	2006	A combinatorial library with dipeptide linkers emanating symmetrically from a central scaffold (bis-3,5-aminomethyl benzoic acid, AMAB) to connect two ethacrynic acid moieties was prepared and decoded via iterative deconvolution, against the isoforms GSTA1-1 and GSTP1-1.	Dipeptides	29-38	glutathione S-transferase pi 1	Homo sapiens	263-270
16802828-4	2006	A combinatorial library with dipeptide linkers emanating symmetrically from a central scaffold (bis-3,5-aminomethyl benzoic acid, AMAB) to connect two ethacrynic acid moieties was prepared and decoded via iterative deconvolution, against the isoforms GSTA1-1 and GSTP1-1.	bis-3,5-aminomethyl benzoic acid	96-128	glutathione S-transferase pi 1	Homo sapiens	263-270
16819303-3	2006	Over-expression of GSTP1 in HEK293 cells inhibited both DMEKK1- and etoposide-induced apoptosis, and inhibited pro-caspase-3 activation and PARP cleavage.	Etoposide	68-77	glutathione S-transferase pi 1	Homo sapiens	19-24
16819303-6	2006	GSTP1 inhibition of etoposide-induced cell apoptosis was mainly due to its ability to suppress MEKK1 kinase activity.	Etoposide	20-29	glutathione S-transferase pi 1	Homo sapiens	0-5
16819303-7	2006	The glutathione-conjugating activity of GSTP1 was essential for the above effects.	Glutathione	4-15	glutathione S-transferase pi 1	Homo sapiens	40-45
16998606-3	2006	In our study we analysed the distribution of single and combined CYP1A1, GSTM1, GSTT1 and GSTP1 genotypes contributing to inter-individual differences in metabolism of xenobiotics and ROS in 125 Slovenian healthy individuals and in 140 patients with sporadic malignant melanoma.	Reactive Oxygen Species	184-187	glutathione S-transferase pi 1	Homo sapiens	90-95
16778223-10	2006	After culture and in vitro exposure to sulforaphane, BITC, or EGCG, the elevated GSTP1 mRNA expression of PBMCs from HAP3 individuals decreased to common expression levels.	sulforaphane	39-51	glutathione S-transferase pi 1	Homo sapiens	81-86
16778223-10	2006	After culture and in vitro exposure to sulforaphane, BITC, or EGCG, the elevated GSTP1 mRNA expression of PBMCs from HAP3 individuals decreased to common expression levels.	benzyl isothiocyanate	53-57	glutathione S-transferase pi 1	Homo sapiens	81-86
16778223-10	2006	After culture and in vitro exposure to sulforaphane, BITC, or EGCG, the elevated GSTP1 mRNA expression of PBMCs from HAP3 individuals decreased to common expression levels.	epigallocatechin gallate	62-66	glutathione S-transferase pi 1	Homo sapiens	81-86
16341694-3	2006	In this study we first examined the effect of PBL extract on the activity of Glutathione S-transferase (GST) isoforms, and found that it inhibited total GST and the alpha class of GST (GSTA), but not the pi class of GST (GSTP), and the mu class of GST (GSTM), activity in Hep G2 cells.	Pentane-2,2,4,4-Tetrol	46-49	glutathione S-transferase pi 1	Homo sapiens	221-225
16707601-0	2006	Glutathione S-transferase P1 polymorphism (Ile105Val) predicts cumulative neuropathy in patients receiving oxaliplatin-based chemotherapy.	Oxaliplatin	107-118	glutathione S-transferase pi 1	Homo sapiens	0-28
16501997-12	2006	The activity promoted by 1-chloro-2,4-dinitrobenzene is significantly correlated to the GSTP1 mRNA expression level (R2=0.77, P<0.001).	Dinitrochlorobenzene	25-52	glutathione S-transferase pi 1	Homo sapiens	88-93
16707601-9	2006	The oxaliplatin-related cumulative neuropathy scored grade 3 was significantly more frequent in patients homozygous for the GSTP1 105Ile allele than in patients homozygous or heterozygous for the GSTP1 105Val allele (odds ratio, 5.75; 95% confidence interval, 1.08-30.74; P = 0.02).	Oxaliplatin	4-15	glutathione S-transferase pi 1	Homo sapiens	124-129
16707601-9	2006	The oxaliplatin-related cumulative neuropathy scored grade 3 was significantly more frequent in patients homozygous for the GSTP1 105Ile allele than in patients homozygous or heterozygous for the GSTP1 105Val allele (odds ratio, 5.75; 95% confidence interval, 1.08-30.74; P = 0.02).	Oxaliplatin	4-15	glutathione S-transferase pi 1	Homo sapiens	196-201
16707601-11	2006	CONCLUSIONS: The results of the current study suggest that the 105Val allele variant of the GSTP1 gene at exon 5 confers a significantly decreased risk of developing severe oxaliplatin-related cumulative neuropathy.	Oxaliplatin	173-184	glutathione S-transferase pi 1	Homo sapiens	92-97
16627975-0	2006	Chemosensitizing multiple drug resistance of human carcinoma by Bicyclol involves attenuated p-glycoprotein, GST-P and Bcl-2.	bicyclol	64-72	glutathione S-transferase pi 1	Homo sapiens	109-114
16213016-0	2006	Transcriptional and post-transcriptional regulation of glutathione S-transferase P1 expression during butyric acid-induced differentiation of K562 cells.	Butyric Acid	102-114	glutathione S-transferase pi 1	Homo sapiens	55-83
16488119-9	2006	The mean erythrocyte GST enzyme activity for GSTP1*-Ile/Val genotype group (3.53 +/- 0.63U/gHb) was significantly lower than that for subjects with GSTP1-Ile/Ile genotype (4.25 +/- 1.07U/gHb, P = 0.004), while subjects with the GSTP1-Val/Val genotype had the lowest enzyme activity (2.44 +/- 0.67U/gHb).	4-hydroxybutyric acid	91-94	glutathione S-transferase pi 1	Homo sapiens	45-50
16488119-9	2006	The mean erythrocyte GST enzyme activity for GSTP1*-Ile/Val genotype group (3.53 +/- 0.63U/gHb) was significantly lower than that for subjects with GSTP1-Ile/Ile genotype (4.25 +/- 1.07U/gHb, P = 0.004), while subjects with the GSTP1-Val/Val genotype had the lowest enzyme activity (2.44 +/- 0.67U/gHb).	4-hydroxybutyric acid	187-190	glutathione S-transferase pi 1	Homo sapiens	45-50
16488119-9	2006	The mean erythrocyte GST enzyme activity for GSTP1*-Ile/Val genotype group (3.53 +/- 0.63U/gHb) was significantly lower than that for subjects with GSTP1-Ile/Ile genotype (4.25 +/- 1.07U/gHb, P = 0.004), while subjects with the GSTP1-Val/Val genotype had the lowest enzyme activity (2.44 +/- 0.67U/gHb).	4-hydroxybutyric acid	187-190	glutathione S-transferase pi 1	Homo sapiens	45-50
16213016-2	2006	In opposition to previously described differentiating inducers which enhance the GST-resistance phenotype, time- and concentration-dependent activation of both erythroid and megakaryocytic differentiation pathways by butyric acid progressively diminished GSTP1 mRNA expression.	Butyric Acid	217-229	glutathione S-transferase pi 1	Homo sapiens	255-260
16213016-3	2006	GSTP1 mRNA expression decreased by 25% (p<0.01) and 64% (p<0.01) in 1mM and 2mM butyric acid-differentiated K562 cells, respectively.	Butyric Acid	86-98	glutathione S-transferase pi 1	Homo sapiens	0-5
16597834-3	2006	We have determined the crystal structure of GSNO bound to dimeric human glutathione transferase P1-1 (hGSTP1-1) at 1.4 A resolution.	S-Nitrosoglutathione	44-48	glutathione S-transferase pi 1	Homo sapiens	102-110
16597834-6	2006	The binding of GSNO to wild-type hGSTP1-1 induces a negative cooperativity with a kinetic process concomitant to the binding process occurring at more physiological temperatures.	S-Nitrosoglutathione	15-19	glutathione S-transferase pi 1	Homo sapiens	33-41
16613325-7	2006	CpG methylation of the p16INK4a, RASSF1A, E cadherin, and GSTP1 genes was correlated to the reduction of mRNA levels in the cell lines, and mRNA expression of these 4 genes were indeed restored by low concentrations (2-6 micromol/L) of As2O3 through demethylation, as well as 1 micromol/L of 5-aza-2"-deoxycytidine.	Arsenic Trioxide	236-241	glutathione S-transferase pi 1	Homo sapiens	58-63
16839232-7	2006	The GSTP1 allelic frequency was 0.78 for the Ile allele and 0.22 for the Val allele and the genotype frequency was 58.4% for Ile/Ile, 38.4% for Ile/Val, and 3.1% for Val/Val.	Valine	73-76	glutathione S-transferase pi 1	Homo sapiens	4-9
16537716-12	2006	A statistically significant effect was seen for SULT1A2 genotype on a 24DNT Hb-adduct; GSTP1 genotype on a 2,4,6-trinitrotoluene Hb-adduct; and SULT1A1, SULT1A2, NAT1, GSTT1, and GSTP1 genotypes on chromosomal aberrations in the exposed workers.	Trinitrotoluene	107-128	glutathione S-transferase pi 1	Homo sapiens	87-92
16613325-7	2006	CpG methylation of the p16INK4a, RASSF1A, E cadherin, and GSTP1 genes was correlated to the reduction of mRNA levels in the cell lines, and mRNA expression of these 4 genes were indeed restored by low concentrations (2-6 micromol/L) of As2O3 through demethylation, as well as 1 micromol/L of 5-aza-2"-deoxycytidine.	Decitabine	292-314	glutathione S-transferase pi 1	Homo sapiens	58-63
16342067-4	2006	In this study, the authors hypothesized that variant GSTP1 genotype would result in reduced inactivation of chemotherapy agents and improved survival in patients with advanced-stage nonsmall cell lung carcinoma (NSCLC), a population that is likely to receive platinum-based chemotherapy.	Platinum	259-267	glutathione S-transferase pi 1	Homo sapiens	53-58
16424821-5	2006	The possible influence of genetic polymorphisms of xenobiotic-metabolizing enzymes involved in styrene biotransformation (EPHX1, GSTT1, GSTM1, GSTP1) and NAT2 on the cytogenetic endpoints was investigated.	Styrene	95-102	glutathione S-transferase pi 1	Homo sapiens	143-148
18225754-0	2007	Expression of genes for redox-dependent glutathione S-transferase isoforms GSTP1-1 and GSTA4-4 in tumor cell during the development doxorubicin resistance.	Doxorubicin	132-143	glutathione S-transferase pi 1	Homo sapiens	75-82
16317430-7	2006	Patients possessing the glutathione S-transferase P1-105 Valine/Valine (GSTP1-105VV) genotype showed a response rate of 67% compared to 21% in patients harbouring at least one GSTP1-105 Isoleucine (GSTP1-105I) allele (P=0.038).	Glutathione	24-35	glutathione S-transferase pi 1	Homo sapiens	72-77
16317430-7	2006	Patients possessing the glutathione S-transferase P1-105 Valine/Valine (GSTP1-105VV) genotype showed a response rate of 67% compared to 21% in patients harbouring at least one GSTP1-105 Isoleucine (GSTP1-105I) allele (P=0.038).	Valine	57-63	glutathione S-transferase pi 1	Homo sapiens	72-77
16317430-11	2006	Testing for TS and GSTP1 polymorphisms may allow identification of gastric cancer patients who will benefit from 5-FU/cisplatin chemotherapy, sparing others the side effects of this chemotherapy.	Fluorouracil	113-117	glutathione S-transferase pi 1	Homo sapiens	19-24
16317430-11	2006	Testing for TS and GSTP1 polymorphisms may allow identification of gastric cancer patients who will benefit from 5-FU/cisplatin chemotherapy, sparing others the side effects of this chemotherapy.	Cisplatin	118-127	glutathione S-transferase pi 1	Homo sapiens	19-24
17067754-0	2006	Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphism.	Polycyclic Aromatic Hydrocarbons	51-83	glutathione S-transferase pi 1	Homo sapiens	105-110
17067754-1	2006	BACKGROUND: Variation in the glutathione S-transferase (GSTP1) gene and occupational polycyclic aromatic hydrocarbons (PAH) exposure are putative prostate cancer risk factors.	Polycyclic Aromatic Hydrocarbons	85-117	glutathione S-transferase pi 1	Homo sapiens	56-61
17067754-1	2006	BACKGROUND: Variation in the glutathione S-transferase (GSTP1) gene and occupational polycyclic aromatic hydrocarbons (PAH) exposure are putative prostate cancer risk factors.	Polycyclic Aromatic Hydrocarbons	119-122	glutathione S-transferase pi 1	Homo sapiens	56-61
17067754-2	2006	An Ile/Val polymorphism in codon 105 of GSTP1 affects its enzymatic activity toward PAH detoxification, a possible mechanism in prostate carcinogenesis.	Polycyclic Aromatic Hydrocarbons	84-87	glutathione S-transferase pi 1	Homo sapiens	40-45
17067754-5	2006	The association of occupational PAH exposure and GSTP1 Ile105Val polymorphism with prostate cancer was tested in multiple logistic regression models adjusting for potential confounders.	Polycyclic Aromatic Hydrocarbons	32-35	glutathione S-transferase pi 1	Homo sapiens	49-54
17067754-8	2006	However, case-only analyses revealed that carriage of the GSTP1 Val(105) variant allele was associated with increasing levels of occupational respiratory PAH exposures from any source and from petroleum (trend test p=0.01 for both).	Polycyclic Aromatic Hydrocarbons	154-157	glutathione S-transferase pi 1	Homo sapiens	58-63
17067754-9	2006	The GSTP1 Val(105) allele was observed most frequently in cases in the highest quartile of occupational respiratory PAH exposures from petroleum (OR=1.74; 95% CI=1.11-2.72) or from any source (OR=1.85; 95% CI=1.19-2.89).	Polycyclic Aromatic Hydrocarbons	116-119	glutathione S-transferase pi 1	Homo sapiens	4-9
17067754-11	2006	CONCLUSIONS: Our results suggest men who carry the GSTP1 Val(105) variant and are exposed at high levels to occupational PAH have increased risk for prostate cancer.	Polycyclic Aromatic Hydrocarbons	121-124	glutathione S-transferase pi 1	Homo sapiens	51-56
16125881-4	2005	The subjects" genetic polymorphisms in the genes that encode the styrene-metabolizing enzymes CYP2E1, CYP2B6, EPHX1, GSTM1, GSTT1 and GSTP1 were determined.	Styrene	65-72	glutathione S-transferase pi 1	Homo sapiens	134-139
16195232-1	2005	We have recently shown that dinitrosyl diglutathionyl iron complex, a possible in vivo nitric oxide (NO) donor, binds with extraordinary affinity to one of the active sites of human glutathione transferase (GST) P1-1 and triggers negative cooperativity in the neighboring subunit of the dimer.	dinitrosyl diglutathionyl	28-53	glutathione S-transferase pi 1	Homo sapiens	182-216
16195232-1	2005	We have recently shown that dinitrosyl diglutathionyl iron complex, a possible in vivo nitric oxide (NO) donor, binds with extraordinary affinity to one of the active sites of human glutathione transferase (GST) P1-1 and triggers negative cooperativity in the neighboring subunit of the dimer.	Iron	54-58	glutathione S-transferase pi 1	Homo sapiens	182-216
16195232-1	2005	We have recently shown that dinitrosyl diglutathionyl iron complex, a possible in vivo nitric oxide (NO) donor, binds with extraordinary affinity to one of the active sites of human glutathione transferase (GST) P1-1 and triggers negative cooperativity in the neighboring subunit of the dimer.	Nitric Oxide	87-99	glutathione S-transferase pi 1	Homo sapiens	182-216
16195232-3	2005	We present here the crystal structure of GST P1-1 in complex with the dinitrosyl diglutathionyl iron ligand at high resolution.	dinitrosyl diglutathionyl iron	70-100	glutathione S-transferase pi 1	Homo sapiens	41-49
16195232-7	2005	Electron paramagnetic resonance spectroscopy studies on intact Escherichia coli cells expressing the recombinant GST P1-1 enzyme indicate that bacterial cells, in response to NO treatment, are able to form the dinitrosyl diglutathionyl iron complex using intracellular iron and GSH.	dinitrosyl diglutathionyl iron	210-240	glutathione S-transferase pi 1	Homo sapiens	113-121
16195232-7	2005	Electron paramagnetic resonance spectroscopy studies on intact Escherichia coli cells expressing the recombinant GST P1-1 enzyme indicate that bacterial cells, in response to NO treatment, are able to form the dinitrosyl diglutathionyl iron complex using intracellular iron and GSH.	Iron	236-240	glutathione S-transferase pi 1	Homo sapiens	113-121
16195232-7	2005	Electron paramagnetic resonance spectroscopy studies on intact Escherichia coli cells expressing the recombinant GST P1-1 enzyme indicate that bacterial cells, in response to NO treatment, are able to form the dinitrosyl diglutathionyl iron complex using intracellular iron and GSH.	Glutathione	278-281	glutathione S-transferase pi 1	Homo sapiens	113-121
15981203-6	2005	The activities of cutaneous gamma-glutamyl transpeptidase (GGT) and glutathione-S-transferase P (GST-P), marker enzymes of tumorigenesis, were found to exhibit higher expression in AO or isolated sanguinarine/TPA treated groups when compared to control.	sanguinarine	196-208	glutathione S-transferase pi 1	Homo sapiens	68-95
16099480-2	2005	The protective effects were attributed to induction of glutathione-S-transferases (GSTs) and aim of the present human study was to find out if coffee causes induction of GSTs and protects against DNA-damage caused by (+/-)-anti-B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE), the DNA-reactive metabolite of benzo(a)pyrene.	p-7,8-dihydrodiol-9,10-epoxide	232-262	glutathione S-transferase pi 1	Homo sapiens	170-174
16099480-2	2005	The protective effects were attributed to induction of glutathione-S-transferases (GSTs) and aim of the present human study was to find out if coffee causes induction of GSTs and protects against DNA-damage caused by (+/-)-anti-B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE), the DNA-reactive metabolite of benzo(a)pyrene.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	264-268	glutathione S-transferase pi 1	Homo sapiens	170-174
16099480-2	2005	The protective effects were attributed to induction of glutathione-S-transferases (GSTs) and aim of the present human study was to find out if coffee causes induction of GSTs and protects against DNA-damage caused by (+/-)-anti-B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE), the DNA-reactive metabolite of benzo(a)pyrene.	Benzo(a)pyrene	302-316	glutathione S-transferase pi 1	Homo sapiens	170-174
15981203-6	2005	The activities of cutaneous gamma-glutamyl transpeptidase (GGT) and glutathione-S-transferase P (GST-P), marker enzymes of tumorigenesis, were found to exhibit higher expression in AO or isolated sanguinarine/TPA treated groups when compared to control.	sanguinarine	196-208	glutathione S-transferase pi 1	Homo sapiens	97-102
15981203-6	2005	The activities of cutaneous gamma-glutamyl transpeptidase (GGT) and glutathione-S-transferase P (GST-P), marker enzymes of tumorigenesis, were found to exhibit higher expression in AO or isolated sanguinarine/TPA treated groups when compared to control.	Tetradecanoylphorbol Acetate	209-212	glutathione S-transferase pi 1	Homo sapiens	68-95
15981203-6	2005	The activities of cutaneous gamma-glutamyl transpeptidase (GGT) and glutathione-S-transferase P (GST-P), marker enzymes of tumorigenesis, were found to exhibit higher expression in AO or isolated sanguinarine/TPA treated groups when compared to control.	Tetradecanoylphorbol Acetate	209-212	glutathione S-transferase pi 1	Homo sapiens	97-102
16220971-1	2005	Human glutathione (GSH) transferase (hGSTP1-1) catalyzes the conversion of antitumor 2-crotonyloxymethyl-2-cycloalkenones (COMCs) to highly reactive exocyclic enone alkylating agents.	Glutathione	19-22	glutathione S-transferase pi 1	Homo sapiens	37-45
16039055-9	2005	In the present study, the relationship between TD and a functional polymorphism of the gene coding for human glutathione S-transferase P1 (GSTP1), an important antioxidant enzyme involved in the detoxification of ROS, was studied in 225 chronic treatment-refractory patients with schizophrenia.	Reactive Oxygen Species	213-216	glutathione S-transferase pi 1	Homo sapiens	109-137
16039055-9	2005	In the present study, the relationship between TD and a functional polymorphism of the gene coding for human glutathione S-transferase P1 (GSTP1), an important antioxidant enzyme involved in the detoxification of ROS, was studied in 225 chronic treatment-refractory patients with schizophrenia.	Reactive Oxygen Species	213-216	glutathione S-transferase pi 1	Homo sapiens	139-144
16039055-10	2005	An isoleucine (Ile) to valine (Val) substitution at codon 105 (Ile105Val) in the GSTP1 gene was genotyped.	Isoleucine	3-13	glutathione S-transferase pi 1	Homo sapiens	81-86
16039055-10	2005	An isoleucine (Ile) to valine (Val) substitution at codon 105 (Ile105Val) in the GSTP1 gene was genotyped.	Isoleucine	15-18	glutathione S-transferase pi 1	Homo sapiens	81-86
16039055-10	2005	An isoleucine (Ile) to valine (Val) substitution at codon 105 (Ile105Val) in the GSTP1 gene was genotyped.	Valine	23-29	glutathione S-transferase pi 1	Homo sapiens	81-86
16039055-10	2005	An isoleucine (Ile) to valine (Val) substitution at codon 105 (Ile105Val) in the GSTP1 gene was genotyped.	Valine	31-34	glutathione S-transferase pi 1	Homo sapiens	81-86
16282887-1	2005	The aim of this study was to evaluate the impact of GSTM1, GSTT1, and GSTP1 gene polymorphism on urinary excretion of unchanged ifosfamide, 2-dechloroethylifosfamide (2DCIF), and 3-dechloroethylifosfamide (3DCIF) with regard to the incidence of ifosfamide-related nephrotoxicity and neurotoxicity in children.	Ifosfamide	128-138	glutathione S-transferase pi 1	Homo sapiens	70-75
16282887-5	2005	In children with polymorphic locus of the GSTP1 gene compared with children with homozygous wild alleles, increased urinary excretion of 3DCIF (P=0.029) and decreased creatinine clearance was found (Mann-Whitney P=0.03; median 81.1 mL/min/1.73 m vs. 105.0 mL/min/1.73 m, respectively).	Creatinine	167-177	glutathione S-transferase pi 1	Homo sapiens	42-47
16282887-9	2005	The results of this analysis indicate that individual reactions to ifosfamide can depend on inherited genetic polymorphisms, especially associated with the GSTP1 gene coding detoxifying enzyme.	Ifosfamide	67-77	glutathione S-transferase pi 1	Homo sapiens	156-161
15880531-9	2005	The prostate has potential for GSTP1-dependent detoxification of ATP-activated N-hydroxy-PhIP but little potential for detoxification of N-acetoxy-PhIP by GSTA1.	Adenosine Triphosphate	65-68	glutathione S-transferase pi 1	Homo sapiens	31-36
15880531-9	2005	The prostate has potential for GSTP1-dependent detoxification of ATP-activated N-hydroxy-PhIP but little potential for detoxification of N-acetoxy-PhIP by GSTA1.	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	79-93	glutathione S-transferase pi 1	Homo sapiens	31-36
16220971-1	2005	Human glutathione (GSH) transferase (hGSTP1-1) catalyzes the conversion of antitumor 2-crotonyloxymethyl-2-cycloalkenones (COMCs) to highly reactive exocyclic enone alkylating agents.	2-crotonyloxymethyl-2-cycloalkenones	85-121	glutathione S-transferase pi 1	Homo sapiens	37-45
16220971-1	2005	Human glutathione (GSH) transferase (hGSTP1-1) catalyzes the conversion of antitumor 2-crotonyloxymethyl-2-cycloalkenones (COMCs) to highly reactive exocyclic enone alkylating agents.	exocyclic enone	149-164	glutathione S-transferase pi 1	Homo sapiens	37-45
16220971-2	2005	In vitro efficacy studies show that the cytotoxicities of the COMCs directly correlate with the level of expression of GSTP1-1 in MCF-7(piGST) versus MCF-7wt breast tumors, indicating that the exocyclic enones are the actual cytotoxic species.	enones	203-209	glutathione S-transferase pi 1	Homo sapiens	119-126
16853517-9	2005	Most importantly, while there is significant singlet oxygen generation from hypericin bound to GST A1-1, binding to GST P1-1 suppresses singlet oxygen generation to almost negligible levels.	Singlet Oxygen	136-150	glutathione S-transferase pi 1	Homo sapiens	116-124
16162701-8	2005	RESULTS: All of the participants were homozygous at the GSTP1 Ala-114 locus.	Alanine	62-65	glutathione S-transferase pi 1	Homo sapiens	56-61
16230413-1	2005	GSTP1 is a member of the glutathione S-transferase enzyme superfamily, which catalyzes the conjugation of electrophiles with glutathione in the process of detoxification.	Glutathione	25-36	glutathione S-transferase pi 1	Homo sapiens	0-5
16162701-9	2005	After controlling for age, sex, and atopic eczema, compared with participants carrying any Val-105 allele, children who were homozygotic for GSTP1 Ile-105 had a significantly increased risk of physician-diagnosed asthma (adjusted odds ratio [adjOR], 1.94; 95% confidence interval [CI], 1.08 to 3.59).	Valine	91-94	glutathione S-transferase pi 1	Homo sapiens	141-146
15800905-4	2005	In PC cells, 5-aza-dC treatment increased expression of GSTP1 mRNA transcripts.	Azacitidine	13-18	glutathione S-transferase pi 1	Homo sapiens	56-61
16295782-6	2005	However, minor G allele frequency of the GSTP1 Ilel105Val polymorphism in AIA group (16.5%) tended to be lower than in the NC group (20.6%).	ilel105val	47-57	glutathione S-transferase pi 1	Homo sapiens	41-46
16295782-6	2005	However, minor G allele frequency of the GSTP1 Ilel105Val polymorphism in AIA group (16.5%) tended to be lower than in the NC group (20.6%).	aia	74-77	glutathione S-transferase pi 1	Homo sapiens	41-46
15999103-2	2005	To investigate the involvement of these detoxifying enzymes in the drug resistance of melanoma, an inducible (Tet-On system) antisense (AS) RNA strategy was used to specifically inhibit GSTP1 expression in A375 cells, a human melanoma cell line expressing high levels of GSTP1 and MRP1.	tetramethylenedisulfotetramine	110-113	glutathione S-transferase pi 1	Homo sapiens	186-191
16091627-6	2005	We have applied Headloop PCR to DNA that had been bisulphite-treated for the selective amplification of methylated sequences of the human GSTP1 gene in the presence of up to a 10(5)-fold excess of unmethylated sequences.	hydrogen sulfite	50-60	glutathione S-transferase pi 1	Homo sapiens	138-143
15888444-2	2005	Spectroscopic and rapid kinetic experiments were performed to detail the interaction of human glutathione S-transferases GSTA1-1, GSTM2-2, and GSTP1-1 with 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX).	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	156-203	glutathione S-transferase pi 1	Homo sapiens	143-150
15888444-2	2005	Spectroscopic and rapid kinetic experiments were performed to detail the interaction of human glutathione S-transferases GSTA1-1, GSTM2-2, and GSTP1-1 with 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX).	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	205-211	glutathione S-transferase pi 1	Homo sapiens	143-150
15888444-8	2005	This complex was tightly stabilized in the active site of GSTP1-1 and GSTM2-2, whereas in GSTA1-1 the release of the 6-mercapto-1-hexanol from the sigma complex was the favored event.	6-mercapto-1-hexanol	117-137	glutathione S-transferase pi 1	Homo sapiens	58-65
15999103-5	2005	Lowering the GSTP1 level significantly increased (about 3.3-fold) the sensitivity of A375-ASPi1 cells to etoposide.	Etoposide	105-114	glutathione S-transferase pi 1	Homo sapiens	13-18
15999103-6	2005	Inhibitors of glutathione synthesis (BSO), GSTs (curcumin, ethacrynic acid), and also of MRPs (MK571, sulphinpyrazone) improved the sensitising effect of GSTP1 AS RNA.	Glutathione	14-25	glutathione S-transferase pi 1	Homo sapiens	154-159
15999103-6	2005	Inhibitors of glutathione synthesis (BSO), GSTs (curcumin, ethacrynic acid), and also of MRPs (MK571, sulphinpyrazone) improved the sensitising effect of GSTP1 AS RNA.	Curcumin	49-57	glutathione S-transferase pi 1	Homo sapiens	154-159
15999103-6	2005	Inhibitors of glutathione synthesis (BSO), GSTs (curcumin, ethacrynic acid), and also of MRPs (MK571, sulphinpyrazone) improved the sensitising effect of GSTP1 AS RNA.	Ethacrynic Acid	59-74	glutathione S-transferase pi 1	Homo sapiens	154-159
15999103-6	2005	Inhibitors of glutathione synthesis (BSO), GSTs (curcumin, ethacrynic acid), and also of MRPs (MK571, sulphinpyrazone) improved the sensitising effect of GSTP1 AS RNA.	verlukast	95-100	glutathione S-transferase pi 1	Homo sapiens	154-159
15999103-6	2005	Inhibitors of glutathione synthesis (BSO), GSTs (curcumin, ethacrynic acid), and also of MRPs (MK571, sulphinpyrazone) improved the sensitising effect of GSTP1 AS RNA.	Sulfinpyrazone	102-117	glutathione S-transferase pi 1	Homo sapiens	154-159
15999103-8	2005	In conclusion, GSTP1 can act in a combined fashion with MRP1 to protect melanoma cells from toxic effects of etoposide.	Etoposide	109-118	glutathione S-transferase pi 1	Homo sapiens	15-20
15863507-5	2005	Down-regulation of the proteasome by antisense oligonucleotides or RNA interference indeed resulted in significant up-regulation of GST P1, suggesting that a decline in the proteasome activity could be directly or indirectly linked to the induction of GST P1.	Oligonucleotides	47-63	glutathione S-transferase pi 1	Homo sapiens	132-138
16000570-9	2005	The more the patients carried GSTP1 variant Val alleles, the poorer the survival rate (adjusted hazard ratio, 1.36; 95% confidence interval, 1.01-1.84; Ptrend = 0.045).	Valine	44-47	glutathione S-transferase pi 1	Homo sapiens	30-35
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Isoleucine	37-40	glutathione S-transferase pi 1	Homo sapiens	30-35
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Isoleucine	51-54	glutathione S-transferase pi 1	Homo sapiens	30-35
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Isoleucine	51-54	glutathione S-transferase pi 1	Homo sapiens	30-35
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Valine	41-44	glutathione S-transferase pi 1	Homo sapiens	30-35
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	30-35
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	30-35
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Isoleucine	51-54	glutathione S-transferase pi 1	Homo sapiens	30-35
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	30-35
15863507-5	2005	Down-regulation of the proteasome by antisense oligonucleotides or RNA interference indeed resulted in significant up-regulation of GST P1, suggesting that a decline in the proteasome activity could be directly or indirectly linked to the induction of GST P1.	Oligonucleotides	47-63	glutathione S-transferase pi 1	Homo sapiens	252-258
16245244-5	2005	RESULTS: Median urinary GSTP1-1 concentrations were significantly (p<0.001) higher in women with preeclampsia [62.2 (4.3-291.2) ng/10 mmol Cr] compared to non-pregnant women with a history of preeclampsia [22.3 (0-142.6) ng/10 mmol Cr]).	Creatinine	142-144	glutathione S-transferase pi 1	Homo sapiens	24-31
16245244-5	2005	RESULTS: Median urinary GSTP1-1 concentrations were significantly (p<0.001) higher in women with preeclampsia [62.2 (4.3-291.2) ng/10 mmol Cr] compared to non-pregnant women with a history of preeclampsia [22.3 (0-142.6) ng/10 mmol Cr]).	Creatinine	235-237	glutathione S-transferase pi 1	Homo sapiens	24-31
16245244-6	2005	In addition, in normotensive pregnant women, urinary GSTP1-1 concentrations were significantly (p<0.01) higher [82.6 (8.3-206.7) ng/10 mmol Cr]) compared to non-pregnant controls [5.1 (0-66.7) ng/10 mmol Cr].	Creatinine	143-145	glutathione S-transferase pi 1	Homo sapiens	53-60
16245244-6	2005	In addition, in normotensive pregnant women, urinary GSTP1-1 concentrations were significantly (p<0.01) higher [82.6 (8.3-206.7) ng/10 mmol Cr]) compared to non-pregnant controls [5.1 (0-66.7) ng/10 mmol Cr].	Creatinine	207-209	glutathione S-transferase pi 1	Homo sapiens	53-60
15829614-3	2005	This resistance was attributed to the induction of certain glutathione S-transferases (hGSTP1-1, hGSTM2-2, and hGSTA1-1) and also for the tripeptide glutathione (GSH) synthesizing enzymes.	Glutathione	59-70	glutathione S-transferase pi 1	Homo sapiens	87-95
15890268-8	2005	Other appear determinant for drug response, such as the common SNPs found in glutathione S-transferase P1 or xereoderma pigmentosum group D enzyme for the activity of oxaliplatin.	Oxaliplatin	167-178	glutathione S-transferase pi 1	Homo sapiens	77-105
15911318-1	2005	Ethacrynic acid (EA) is a glutathione-s-transferase pi (GSTP1-1) inhibitor.	Ethacrynic Acid	0-15	glutathione S-transferase pi 1	Homo sapiens	56-63
15911318-1	2005	Ethacrynic acid (EA) is a glutathione-s-transferase pi (GSTP1-1) inhibitor.	Ethacrynic Acid	17-19	glutathione S-transferase pi 1	Homo sapiens	56-63
15911318-4	2005	Structure-activity analysis indicates that replacements of chlorides of EA by methyl, bromide, and fluoride at 3" position remain the GSTP1-1 inhibitory effect.	Chlorides	59-68	glutathione S-transferase pi 1	Homo sapiens	134-141
15911318-4	2005	Structure-activity analysis indicates that replacements of chlorides of EA by methyl, bromide, and fluoride at 3" position remain the GSTP1-1 inhibitory effect.	Ethacrynic Acid	72-74	glutathione S-transferase pi 1	Homo sapiens	134-141
15911318-4	2005	Structure-activity analysis indicates that replacements of chlorides of EA by methyl, bromide, and fluoride at 3" position remain the GSTP1-1 inhibitory effect.	methyl radical	78-84	glutathione S-transferase pi 1	Homo sapiens	134-141
15911318-4	2005	Structure-activity analysis indicates that replacements of chlorides of EA by methyl, bromide, and fluoride at 3" position remain the GSTP1-1 inhibitory effect.	Bromides	86-93	glutathione S-transferase pi 1	Homo sapiens	134-141
15911318-4	2005	Structure-activity analysis indicates that replacements of chlorides of EA by methyl, bromide, and fluoride at 3" position remain the GSTP1-1 inhibitory effect.	Fluorides	99-107	glutathione S-transferase pi 1	Homo sapiens	134-141
15911318-6	2005	These data suggest that the substitution of 3" position of EA is necessary for inhibiting GSTP1-1 activity.	Ethacrynic Acid	59-61	glutathione S-transferase pi 1	Homo sapiens	90-97
15746163-10	2005	Butyrate induced GSTP1, GSTM2, and GSTA4 in HT29 as previously confirmed by other methods (northern blot/qPCR).	Butyrates	0-8	glutathione S-transferase pi 1	Homo sapiens	17-22
15729709-0	2005	A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population.	Methamphetamine	79-94	glutathione S-transferase pi 1	Homo sapiens	13-41
15900216-5	2005	The GSTP1 gene displays a polymorphism at codon 105 resulting in an Ile to Val substitution, which alters the enzymatic activity of the protein, and this has been suggested as a putative high-risk genotype in various cancers.	Isoleucine	68-71	glutathione S-transferase pi 1	Homo sapiens	4-9
15900216-5	2005	The GSTP1 gene displays a polymorphism at codon 105 resulting in an Ile to Val substitution, which alters the enzymatic activity of the protein, and this has been suggested as a putative high-risk genotype in various cancers.	Valine	75-78	glutathione S-transferase pi 1	Homo sapiens	4-9
15949677-2	2005	We have recently purified, identified and characterized a pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye which specifically and saturably binds to the two forms of zeaxanthin endogenously found in the foveal region.	Zeaxanthins	111-121	glutathione S-transferase pi 1	Homo sapiens	99-104
15949677-3	2005	In this report, we studied the synergistic antioxidant role of zeaxanthin and GSTP1 in egg yolk phosphatidylcholine (EYPC) liposomes using hydrophilic 2,2"-azobis(2-methyl-propionamidine) dihydrochloride (AAPH) and lipophilic 2,2"-azobis(2,4-dimethylvaleronitrile) (AMVN) as lipid peroxyl radical generators.	Phosphatidylcholines	96-115	glutathione S-transferase pi 1	Homo sapiens	78-83
15949677-3	2005	In this report, we studied the synergistic antioxidant role of zeaxanthin and GSTP1 in egg yolk phosphatidylcholine (EYPC) liposomes using hydrophilic 2,2"-azobis(2-methyl-propionamidine) dihydrochloride (AAPH) and lipophilic 2,2"-azobis(2,4-dimethylvaleronitrile) (AMVN) as lipid peroxyl radical generators.	eypc	117-121	glutathione S-transferase pi 1	Homo sapiens	78-83
15949677-4	2005	The two zeaxanthin diastereomers displayed synergistic antioxidant effects against both azo lipid peroxyl radical generators when bound to GSTP1.	Zeaxanthins	8-18	glutathione S-transferase pi 1	Homo sapiens	139-144
15949677-4	2005	The two zeaxanthin diastereomers displayed synergistic antioxidant effects against both azo lipid peroxyl radical generators when bound to GSTP1.	azo lipid peroxyl radical	88-113	glutathione S-transferase pi 1	Homo sapiens	139-144
15949677-5	2005	In the presence of GSTP1, nondietary (3R,3"S-meso)-zeaxanthin was observed to be a better antioxidant than dietary (3R,3"R)-zeaxanthin.	nondietary	26-36	glutathione S-transferase pi 1	Homo sapiens	19-24
15949677-5	2005	In the presence of GSTP1, nondietary (3R,3"S-meso)-zeaxanthin was observed to be a better antioxidant than dietary (3R,3"R)-zeaxanthin.	(3r,3"s-meso)-zeaxanthin	37-61	glutathione S-transferase pi 1	Homo sapiens	19-24
15949677-7	2005	Carotenoid degradation profiles indicated that the zeaxanthin diastereomers in association with GSTP1 were more resistant to degradation which may account for the synergistic antioxidant effects.	Carotenoids	0-10	glutathione S-transferase pi 1	Homo sapiens	96-101
15949677-7	2005	Carotenoid degradation profiles indicated that the zeaxanthin diastereomers in association with GSTP1 were more resistant to degradation which may account for the synergistic antioxidant effects.	Zeaxanthins	51-61	glutathione S-transferase pi 1	Homo sapiens	96-101
15867371-1	2005	Selected 7-nitro-2,1,3-benzoxadiazole derivatives have been recently found very efficient inhibitors of glutathione S-transferase (GST) P1-1, an enzyme which displays antiapoptotic activity and is also involved in the cellular resistance to anticancer drugs.	7-nitro-2,1,3-benzoxadiazole	9-37	glutathione S-transferase pi 1	Homo sapiens	104-140
15867371-5	2005	The cytotoxic mechanism of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, the most effective GSTP1-1 inhibitor, has been carefully investigated in leukemic CCRF-CEM and K562 cell lines.	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	27-74	glutathione S-transferase pi 1	Homo sapiens	95-102
15867371-6	2005	Western blot and immunoprecipitation analyzes have shown that 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol promotes in both cell lines the dissociation of the GSTP1-1 in a complex with c-jun NH2-terminal kinase (JNK).	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	62-109	glutathione S-transferase pi 1	Homo sapiens	162-169
15932063-12	2005	The risk of colorectal cancer increased as putative high-risk genotypes increased for the combined genotypes of GSTM1 null, GSTT1 null, and either GSTP1 valine heterozygosity or GSTP1 valine homozygosity (OR = 2.69, 95% CI: 1.02-7.11).	Valine	153-159	glutathione S-transferase pi 1	Homo sapiens	147-152
15932063-12	2005	The risk of colorectal cancer increased as putative high-risk genotypes increased for the combined genotypes of GSTM1 null, GSTT1 null, and either GSTP1 valine heterozygosity or GSTP1 valine homozygosity (OR = 2.69, 95% CI: 1.02-7.11).	Valine	184-190	glutathione S-transferase pi 1	Homo sapiens	178-183
15638917-0	2005	Genetic polymorphism of glutathione S-transferase genes (GSTM1, GSTT1 and GSTP1) and susceptibility to prostate cancer in Northern India.	Glutathione	24-35	glutathione S-transferase pi 1	Homo sapiens	74-79
15471539-7	2005	One post-translational modification, phosphorylation of a serine residue in the C-terminal portion of GSTP1 where JNK binds, was identified in GSTP1 purified from Kato III cells, but not in GSTP1 purified from human erythrocytes.	Serine	58-64	glutathione S-transferase pi 1	Homo sapiens	102-107
15471539-7	2005	One post-translational modification, phosphorylation of a serine residue in the C-terminal portion of GSTP1 where JNK binds, was identified in GSTP1 purified from Kato III cells, but not in GSTP1 purified from human erythrocytes.	Serine	58-64	glutathione S-transferase pi 1	Homo sapiens	143-148
15471539-7	2005	One post-translational modification, phosphorylation of a serine residue in the C-terminal portion of GSTP1 where JNK binds, was identified in GSTP1 purified from Kato III cells, but not in GSTP1 purified from human erythrocytes.	Serine	58-64	glutathione S-transferase pi 1	Homo sapiens	143-148
16787314-4	2005	Earlier we reported haloenol lactone 1 as a site-directed GSTP1 inactivator.	haloenol lactone	20-36	glutathione S-transferase pi 1	Homo sapiens	58-63
16787314-5	2005	We proposed that enzymatic hydrolysis of the haloenol lactone may be the initial step of GSTP1 chemical modification, resulting in the inactivation of the enzyme.	haloenol lactone	45-61	glutathione S-transferase pi 1	Homo sapiens	89-94
16787314-12	2005	To probe the role of Cys-47 in the inactivation of GSTP1 by compound 1, we prepared mutant C47A GSTP1.	Cysteine	21-24	glutathione S-transferase pi 1	Homo sapiens	51-56
16787314-13	2005	The mutant GSTP1 still showed good activity toward CDNB, but it lost susceptibility to the inactivation by compound 1.	Dinitrochlorobenzene	51-55	glutathione S-transferase pi 1	Homo sapiens	11-16
15231573-4	2005	Stable transfection of GSTP1 into Raji cells decreased the amount of As(2)O(3)-induced apoptosis.	Arsenic Trioxide	69-78	glutathione S-transferase pi 1	Homo sapiens	23-28
15231573-6	2005	Forced expression of GSTP1 by transfection of Raji cells significantly decreased the basal amount of H(2)O(2) and its levels after therapeutic concentration of As(2)O(3) treatment.	Water	101-106	glutathione S-transferase pi 1	Homo sapiens	21-26
15231573-6	2005	Forced expression of GSTP1 by transfection of Raji cells significantly decreased the basal amount of H(2)O(2) and its levels after therapeutic concentration of As(2)O(3) treatment.	as(2)o	160-166	glutathione S-transferase pi 1	Homo sapiens	21-26
15231573-7	2005	Added exogenous H(2)O(2) was removed more rapidly, which correlated with a greater decrease in reduced glutathione level in Raji clones expressing GSTP1 than in those clones without GSTP1 expression.	Hydrogen Peroxide	16-24	glutathione S-transferase pi 1	Homo sapiens	147-152
15231573-7	2005	Added exogenous H(2)O(2) was removed more rapidly, which correlated with a greater decrease in reduced glutathione level in Raji clones expressing GSTP1 than in those clones without GSTP1 expression.	Hydrogen Peroxide	16-24	glutathione S-transferase pi 1	Homo sapiens	182-187
15231573-7	2005	Added exogenous H(2)O(2) was removed more rapidly, which correlated with a greater decrease in reduced glutathione level in Raji clones expressing GSTP1 than in those clones without GSTP1 expression.	Glutathione	103-114	glutathione S-transferase pi 1	Homo sapiens	147-152
15231573-9	2005	These data suggest that GSTP1 blocks As(2)O(3)-induced apoptosis in lymphoma cells by decreasing intracellular amounts of H(2)O(2) by catabolism and H(2)O(2) production by decreasing the intracellular retention of As(2)O(3).	(2)o(3)	39-46	glutathione S-transferase pi 1	Homo sapiens	24-29
15231573-9	2005	These data suggest that GSTP1 blocks As(2)O(3)-induced apoptosis in lymphoma cells by decreasing intracellular amounts of H(2)O(2) by catabolism and H(2)O(2) production by decreasing the intracellular retention of As(2)O(3).	Hydrogen Peroxide	122-130	glutathione S-transferase pi 1	Homo sapiens	24-29
15231573-9	2005	These data suggest that GSTP1 blocks As(2)O(3)-induced apoptosis in lymphoma cells by decreasing intracellular amounts of H(2)O(2) by catabolism and H(2)O(2) production by decreasing the intracellular retention of As(2)O(3).	Hydrogen Peroxide	149-157	glutathione S-transferase pi 1	Homo sapiens	24-29
15231573-9	2005	These data suggest that GSTP1 blocks As(2)O(3)-induced apoptosis in lymphoma cells by decreasing intracellular amounts of H(2)O(2) by catabolism and H(2)O(2) production by decreasing the intracellular retention of As(2)O(3).	as(2)o	37-43	glutathione S-transferase pi 1	Homo sapiens	24-29
15934438-2	2005	Glutathione S-transferase (GST) is involved in the detoxification of ROS and genetic polymorphisms of GSTM1, GSTT1 and GSTP1 are associated with altered enzyme activity.	Reactive Oxygen Species	69-72	glutathione S-transferase pi 1	Homo sapiens	119-124
15565566-3	2005	RESULTS: After adjusting for age, tumor stage, and the use of radiotherapy and tamoxifen, women who were homozygous for the variant GSTP1 105Val allele had a 60% reduction in mortality risk compared with women who were homozygous for the Ile allele (hazard ratio, 0.4; 95% confidence interval, 0.2-0.8).	Tamoxifen	79-88	glutathione S-transferase pi 1	Homo sapiens	132-137
15533597-6	2004	Electrophoretic mobility shift assays show that DNA binding activity is exclusively observed in GSTP1-1-expressing cells and is increased after stimulation with hydrogen peroxide, TPA, tert-butylhydroquinone and doxorubicin.	Hydrogen Peroxide	161-178	glutathione S-transferase pi 1	Homo sapiens	96-103
15533597-6	2004	Electrophoretic mobility shift assays show that DNA binding activity is exclusively observed in GSTP1-1-expressing cells and is increased after stimulation with hydrogen peroxide, TPA, tert-butylhydroquinone and doxorubicin.	2-tert-butylhydroquinone	185-207	glutathione S-transferase pi 1	Homo sapiens	96-103
15533597-6	2004	Electrophoretic mobility shift assays show that DNA binding activity is exclusively observed in GSTP1-1-expressing cells and is increased after stimulation with hydrogen peroxide, TPA, tert-butylhydroquinone and doxorubicin.	Doxorubicin	212-223	glutathione S-transferase pi 1	Homo sapiens	96-103
15500952-0	2004	GSTP1 affects chemoresistance against camptothecin in human lung adenocarcinoma cells.	Camptothecin	38-50	glutathione S-transferase pi 1	Homo sapiens	0-5
15500952-1	2004	Glutathione S-transferase P1 (GSTP1) is known as a xenobiotic enzyme through conjugation of glutathione and also as an inhibitor of Jun N-terminal kinase (JNK).	Glutathione	92-103	glutathione S-transferase pi 1	Homo sapiens	0-28
15500952-6	2004	These results suggest that GSTP1 has protective effects against camptothecin-induced necrosis in subset of human lung adenocarcinoma through glutathione conjugation.	Camptothecin	64-76	glutathione S-transferase pi 1	Homo sapiens	27-32
15500952-6	2004	These results suggest that GSTP1 has protective effects against camptothecin-induced necrosis in subset of human lung adenocarcinoma through glutathione conjugation.	Glutathione	141-152	glutathione S-transferase pi 1	Homo sapiens	27-32
15500952-1	2004	Glutathione S-transferase P1 (GSTP1) is known as a xenobiotic enzyme through conjugation of glutathione and also as an inhibitor of Jun N-terminal kinase (JNK).	Glutathione	92-103	glutathione S-transferase pi 1	Homo sapiens	30-35
15500952-2	2004	We intended to investigate whether GSTP1 affects chemoresistance against camptothecin in human lung adenocarcinoma cells.	Camptothecin	73-85	glutathione S-transferase pi 1	Homo sapiens	35-40
15500952-3	2004	Camptothecin induced GSTP1 expression.	Camptothecin	0-12	glutathione S-transferase pi 1	Homo sapiens	21-26
15500952-4	2004	Downregulation of GSTP1 increased necrosis induced by camptothecin in A549 cells but not in PC-14 and RERF-LC-KJ cells.	Camptothecin	54-66	glutathione S-transferase pi 1	Homo sapiens	18-23
16599007-8	2004	These findings indicate that GCLC polymorphisms that affect GSH production also affect methylmercury retention, and that GSTP1 may play a role in conjugating methylmercury with GSH.	Glutathione	177-180	glutathione S-transferase pi 1	Homo sapiens	121-126
15585627-6	2004	RESULTS: There was a significant stepwise increment of plasma GSTP1-1 concentration from CS I to CS IV (P < 0.05).	Cesium	89-91	glutathione S-transferase pi 1	Homo sapiens	62-69
15585627-6	2004	RESULTS: There was a significant stepwise increment of plasma GSTP1-1 concentration from CS I to CS IV (P < 0.05).	Cesium	97-99	glutathione S-transferase pi 1	Homo sapiens	62-69
15585627-7	2004	Of the 54 patients with CS III or IV treated with CHOP, 28 (52%) had elevated plasma GSTP1-1 levels.	Cesium	24-26	glutathione S-transferase pi 1	Homo sapiens	85-92
15585627-9	2004	The CR rates in patients at CS III and CS IV treated by CHOP, 55.2% (14 of 26) and 16.0% (5 of 28) for the low and high plasma GSTP1-1 groups, respectively, were significantly different (P < 0.01).	Chromium	4-6	glutathione S-transferase pi 1	Homo sapiens	127-134
15557397-5	2004	In fibroblasts expressing the wild-type GSTP1, TEGDMA both inhibited and potentiated GSTP1 activity at high (IC50 = 1.1 mM) and low concentrations, respectively.	triethylene glycol dimethacrylate	47-53	glutathione S-transferase pi 1	Homo sapiens	40-45
15557397-5	2004	In fibroblasts expressing the wild-type GSTP1, TEGDMA both inhibited and potentiated GSTP1 activity at high (IC50 = 1.1 mM) and low concentrations, respectively.	triethylene glycol dimethacrylate	47-53	glutathione S-transferase pi 1	Homo sapiens	85-90
15557397-7	2004	Biochemical analysis of GSTP1 inhibition revealed that TEGDMA is a non-competitive antagonist with respect to GSH and substrate.	triethylene glycol dimethacrylate	55-61	glutathione S-transferase pi 1	Homo sapiens	24-29
15604283-2	2004	GSTP1 phosphorylation by PKA was glutathione (GSH)-dependent, whereas phosphorylation by PKC did not require but was significantly enhanced by GSH.	Glutathione	33-44	glutathione S-transferase pi 1	Homo sapiens	0-5
15604283-2	2004	GSTP1 phosphorylation by PKA was glutathione (GSH)-dependent, whereas phosphorylation by PKC did not require but was significantly enhanced by GSH.	Glutathione	46-49	glutathione S-transferase pi 1	Homo sapiens	0-5
15604283-3	2004	In the presence of GSH, the stoichiometry of phosphorylation was 0.4 +/- 0.03 and 0.53 +/- 0.02 mol incorporated phosphate per mole of dimeric GSTP1 protein.	Glutathione	19-22	glutathione S-transferase pi 1	Homo sapiens	143-148
15604283-3	2004	In the presence of GSH, the stoichiometry of phosphorylation was 0.4 +/- 0.03 and 0.53 +/- 0.02 mol incorporated phosphate per mole of dimeric GSTP1 protein.	Phosphates	113-122	glutathione S-transferase pi 1	Homo sapiens	143-148
15604283-4	2004	The GSTP1 protein was phosphorylated, in the presence of GSH, by eight different PKC isoforms (alpha, betaIota, betaIotaIota, delta, epsilon, gamma, eta, and zeta), belonging to the three major PKC subclasses, albeit with various efficiencies.	Glutathione	57-60	glutathione S-transferase pi 1	Homo sapiens	4-9
15604283-7	2004	Peptide phosphorylation analyses and both phosphorylation and enzyme kinetic studies with GSTP1 proteins mutated at candidate amino acid residues established Ser-42 and Ser-184 as putative phospho-acceptor residues for both kinases in the GSTP1 protein.	Serine	158-161	glutathione S-transferase pi 1	Homo sapiens	90-95
15604283-7	2004	Peptide phosphorylation analyses and both phosphorylation and enzyme kinetic studies with GSTP1 proteins mutated at candidate amino acid residues established Ser-42 and Ser-184 as putative phospho-acceptor residues for both kinases in the GSTP1 protein.	Serine	169-172	glutathione S-transferase pi 1	Homo sapiens	90-95
15604283-9	2004	The GSH-dependence of the phosphorylation suggests that under high intracellular GSH conditions, such as is present in most drug-resistant tumors, the GSTP1 protein will exist in a hyper-phosphorylated and enzymatically more active state.	Glutathione	4-7	glutathione S-transferase pi 1	Homo sapiens	151-156
15604283-9	2004	The GSH-dependence of the phosphorylation suggests that under high intracellular GSH conditions, such as is present in most drug-resistant tumors, the GSTP1 protein will exist in a hyper-phosphorylated and enzymatically more active state.	Glutathione	81-84	glutathione S-transferase pi 1	Homo sapiens	151-156
15355982-9	2004	Like-wise, dietary (3R,3"R)-zeaxanthin displayed alterations in its CD spectrum in association with GSTP1 and XBP.	Cadmium	68-70	glutathione S-transferase pi 1	Homo sapiens	100-105
15355982-12	2004	These results indicate that GSTP1 is a specific XBP in human macula that interacts with (3R,3"S-meso)-zeaxanthin and dietary (3R,3"R)-zeaxanthin in contrast to apparently weaker interactions with (3R,3"R,6"R)-lutein.	(3r,3"s-meso)-zeaxanthin	88-112	glutathione S-transferase pi 1	Homo sapiens	28-33
15355982-12	2004	These results indicate that GSTP1 is a specific XBP in human macula that interacts with (3R,3"S-meso)-zeaxanthin and dietary (3R,3"R)-zeaxanthin in contrast to apparently weaker interactions with (3R,3"R,6"R)-lutein.	Zeaxanthins	125-144	glutathione S-transferase pi 1	Homo sapiens	28-33
15355982-12	2004	These results indicate that GSTP1 is a specific XBP in human macula that interacts with (3R,3"S-meso)-zeaxanthin and dietary (3R,3"R)-zeaxanthin in contrast to apparently weaker interactions with (3R,3"R,6"R)-lutein.	Lutein	196-215	glutathione S-transferase pi 1	Homo sapiens	28-33
15256483-5	2004	Therefore, we hypothesized that individuals possessing the low activity genotypes of GSTM1, GSTT1 and/or GSTP1 (i.e. the GSTM1 null, GSTT1 null and GSTP1 AB/BB genotypes, respectively) may exhibit a stronger marine n-3 fatty acid-breast cancer association than their high activity counterparts.	Fatty Acids, Omega-3	215-229	glutathione S-transferase pi 1	Homo sapiens	105-110
15466980-8	2004	These results indicate that the mEH, GSTP1, and GSTM1 polymorphisms may play a role in sensitivity or genetic susceptibility to the genotoxic effects of PAH exposure in the coke-oven workers.	Polycyclic Aromatic Hydrocarbons	153-156	glutathione S-transferase pi 1	Homo sapiens	37-42
15336536-4	2004	The fusion protein GST.P0 as well as GST.P1/GST.P2 was phosphorylated in cells as detected by incorporation of (32)P and reactivity with monoclonal anti-phosphoserine antibody.	Phosphorus-32	111-116	glutathione S-transferase pi 1	Homo sapiens	37-43
15336536-4	2004	The fusion protein GST.P0 as well as GST.P1/GST.P2 was phosphorylated in cells as detected by incorporation of (32)P and reactivity with monoclonal anti-phosphoserine antibody.	Phosphoserine	153-166	glutathione S-transferase pi 1	Homo sapiens	37-43
15313406-3	2004	In the present study we examined the inhibitory effect of several chemopreventive agents on the tumor necrosis factor (TNF) alpha- or 12-O-tetradecanoylphorbol 13 acetate (TPA)-induced promoter activity of GSTP1-1, as demonstrated by transient transfection experiments in K562 and U937 leukemia cells.	alpha- or	124-133	glutathione S-transferase pi 1	Homo sapiens	206-213
15479622-5	2004	A significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); compared with never-drinking women with Ile/Ile genotype, ever-drinking women with the GSTP1 Val allele had almost a three-fold risk of breast cancer (OR = 2.9, 95 % CI = 1.05-7.85), whereas never-drinking women with Val allele had half this risk (OR = 0.5, 95 % CI = 0.27-0.93).	Alcohols	70-77	glutathione S-transferase pi 1	Homo sapiens	51-56
15479622-5	2004	A significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); compared with never-drinking women with Ile/Ile genotype, ever-drinking women with the GSTP1 Val allele had almost a three-fold risk of breast cancer (OR = 2.9, 95 % CI = 1.05-7.85), whereas never-drinking women with Val allele had half this risk (OR = 0.5, 95 % CI = 0.27-0.93).	Alcohols	70-77	glutathione S-transferase pi 1	Homo sapiens	205-210
15479622-5	2004	A significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); compared with never-drinking women with Ile/Ile genotype, ever-drinking women with the GSTP1 Val allele had almost a three-fold risk of breast cancer (OR = 2.9, 95 % CI = 1.05-7.85), whereas never-drinking women with Val allele had half this risk (OR = 0.5, 95 % CI = 0.27-0.93).	Valine	211-214	glutathione S-transferase pi 1	Homo sapiens	51-56
15479622-5	2004	A significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); compared with never-drinking women with Ile/Ile genotype, ever-drinking women with the GSTP1 Val allele had almost a three-fold risk of breast cancer (OR = 2.9, 95 % CI = 1.05-7.85), whereas never-drinking women with Val allele had half this risk (OR = 0.5, 95 % CI = 0.27-0.93).	Valine	211-214	glutathione S-transferase pi 1	Homo sapiens	205-210
15479622-6	2004	Our findings suggest that the GSTP1 polymorphism influences individual susceptibility to breast cancer in the Korean women and this effect may be modified by alcohol consumption.	Alcohols	158-165	glutathione S-transferase pi 1	Homo sapiens	30-35
15313406-3	2004	In the present study we examined the inhibitory effect of several chemopreventive agents on the tumor necrosis factor (TNF) alpha- or 12-O-tetradecanoylphorbol 13 acetate (TPA)-induced promoter activity of GSTP1-1, as demonstrated by transient transfection experiments in K562 and U937 leukemia cells.	Tetradecanoylphorbol Acetate	134-170	glutathione S-transferase pi 1	Homo sapiens	206-213
15161912-8	2004	Immunoblot analysis of H69AR vesicles revealed the unexpected membrane association of GSH S-transferase P1-1 (GSTP1-1).	Glutathione	86-89	glutathione S-transferase pi 1	Homo sapiens	110-117
15313406-3	2004	In the present study we examined the inhibitory effect of several chemopreventive agents on the tumor necrosis factor (TNF) alpha- or 12-O-tetradecanoylphorbol 13 acetate (TPA)-induced promoter activity of GSTP1-1, as demonstrated by transient transfection experiments in K562 and U937 leukemia cells.	Tetradecanoylphorbol Acetate	172-175	glutathione S-transferase pi 1	Homo sapiens	206-213
15313406-5	2004	Our results demonstrate the ability of selected chemopreventive agents to decrease GSTP1-1 gene expression mechanisms and could thus contribute to reduce the incidence of glutathione related drug resistance in human leukemia.	Glutathione	171-182	glutathione S-transferase pi 1	Homo sapiens	83-90
15313425-1	2004	GSTP1-1 gene expression mechanisms were investigated in hemin-induced erythroid differentiation of K562 cells.	Hemin	56-61	glutathione S-transferase pi 1	Homo sapiens	0-7
15313425-6	2004	GSTP1-1 mRNA stability analysis using actinomycin D as an inhibitor of mRNA neosynthesis showed that mRNA half-life was doubled in hemin-induced erythroid differentiation of K562 cells.	Dactinomycin	38-51	glutathione S-transferase pi 1	Homo sapiens	0-7
15313175-5	2004	Using the FLAG-ATM recombinant protein, GST-p53 serine 15 phosphorylation increased in the presence of damaged DNA.	Serine	48-54	glutathione S-transferase pi 1	Homo sapiens	40-45
15147239-11	2004	This site, located near Trp-20, may be related to the buffer-binding site observed in GSTP1-1.	Tryptophan	24-27	glutathione S-transferase pi 1	Homo sapiens	86-93
15234070-2	2004	In this study we investigated the inhibitory effects of thonningianin A (Th A), a novel antioxidant isolated from the medicinal herb, Thonningia sanguinea on uncharacterized rat liver GST and human GST P1-1.	thonningianin A	56-71	glutathione S-transferase pi 1	Homo sapiens	198-206
15234070-8	2004	While Th A showed competitive inhibition towards CDNB it exhibited non-competitive inhibition towards GSH of the human GST P1-1.	Glutathione	102-105	glutathione S-transferase pi 1	Homo sapiens	119-127
15279901-0	2004	A methylated oligonucleotide induced methylation of GSTP1 promoter and suppressed its expression in A549 lung adenocarcinoma cells.	Oligonucleotides	13-28	glutathione S-transferase pi 1	Homo sapiens	52-57
15279901-2	2004	Though it was reported that GSTP1 gene is suppressed by cytosine-guanine (CpG) island methylation of its promoter, this promoter is not strongly methylated and GSTP1 protein is highly expressed in lung cancer.	cytosine-guanine	56-72	glutathione S-transferase pi 1	Homo sapiens	28-33
15279901-3	2004	We intended to induce methylation of GSTP1 CpG island by using a methylated sense oligonucleotide complementary to this region.	Oligonucleotides	82-97	glutathione S-transferase pi 1	Homo sapiens	37-42
15279901-4	2004	When we transduced the methylated oligonucleotides to A549 lung adenocarcinoma cells, methylation of the GSTP1 promoter and reduction of GSTP1 expression was induced, cell viability was reduced; however, chemoresistance against cisplatin has not clearly changed.	Oligonucleotides	34-50	glutathione S-transferase pi 1	Homo sapiens	105-110
15279901-4	2004	When we transduced the methylated oligonucleotides to A549 lung adenocarcinoma cells, methylation of the GSTP1 promoter and reduction of GSTP1 expression was induced, cell viability was reduced; however, chemoresistance against cisplatin has not clearly changed.	Oligonucleotides	34-50	glutathione S-transferase pi 1	Homo sapiens	137-142
15279901-4	2004	When we transduced the methylated oligonucleotides to A549 lung adenocarcinoma cells, methylation of the GSTP1 promoter and reduction of GSTP1 expression was induced, cell viability was reduced; however, chemoresistance against cisplatin has not clearly changed.	Cisplatin	228-237	glutathione S-transferase pi 1	Homo sapiens	105-110
15298956-0	2004	Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-26	glutathione S-transferase pi 1	Homo sapiens	123-128
15298956-8	2004	In conclusion, CYP1A1, GSTM1, and GSTP1 genotyping seems to be a risk predictor of BPDE-DNA adduct formation in leukocytes.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	83-87	glutathione S-transferase pi 1	Homo sapiens	34-39
15115887-5	2004	Using recombinant alpha, mu, pi and theta class human GSTs, we demonstrated that only hGSTP1-1 displays significant activity toward atrazine (7.1 nmol/min/mg protein).	Atrazine	132-140	glutathione S-transferase pi 1	Homo sapiens	86-94
15115887-8	2004	Docking studies of the atrazine-GST conjugate in the hGSTP1-1 substrate-binding site were used to elucidate a basis for the dramatic difference in activity between mouse GSTP1-1 and GSTP2-2 (7.14 versus 0.02 nmol/min/mg protein, respectively).	Atrazine	23-31	glutathione S-transferase pi 1	Homo sapiens	53-59
15377160-2	2004	To determine how the parent hormone, 17 beta-estradiol (E(2)), is metabolized, we used recombinant, purified phase I enzymes, cytochrome P450 (CYP) 1A1 and 1B1, with the phase II enzymes catechol-O-methyltransferase (COMT) and glutathione S-transferase P1 (GSTP1), all of which are expressed in breast tissue.	Estradiol	37-54	glutathione S-transferase pi 1	Homo sapiens	227-255
15377160-2	2004	To determine how the parent hormone, 17 beta-estradiol (E(2)), is metabolized, we used recombinant, purified phase I enzymes, cytochrome P450 (CYP) 1A1 and 1B1, with the phase II enzymes catechol-O-methyltransferase (COMT) and glutathione S-transferase P1 (GSTP1), all of which are expressed in breast tissue.	Estradiol	37-54	glutathione S-transferase pi 1	Homo sapiens	257-262
15377160-4	2004	The oxidation of E(2) to 2-OHE(2) and 4-OHE(2) was exclusively regulated by CYP1A1 and 1B1, regardless of the presence or concentration of COMT and GSTP1.	Estradiol	17-21	glutathione S-transferase pi 1	Homo sapiens	148-153
15377160-6	2004	Similarly, GSTP1 yielded two conjugates, 2-OHE(2)-1-SG and 2-OHE(2)-4-SG, from the corresponding quinone 2-hydroxyestradiol-quinone and one conjugate, 4-OHE(2)-2-SG, from 4-hydroxyestradiol-quinone.	2-ohe	41-46	glutathione S-transferase pi 1	Homo sapiens	11-16
15377160-6	2004	Similarly, GSTP1 yielded two conjugates, 2-OHE(2)-1-SG and 2-OHE(2)-4-SG, from the corresponding quinone 2-hydroxyestradiol-quinone and one conjugate, 4-OHE(2)-2-SG, from 4-hydroxyestradiol-quinone.	2-ohe	59-64	glutathione S-transferase pi 1	Homo sapiens	11-16
15377160-6	2004	Similarly, GSTP1 yielded two conjugates, 2-OHE(2)-1-SG and 2-OHE(2)-4-SG, from the corresponding quinone 2-hydroxyestradiol-quinone and one conjugate, 4-OHE(2)-2-SG, from 4-hydroxyestradiol-quinone.	quinone	97-104	glutathione S-transferase pi 1	Homo sapiens	11-16
15377160-6	2004	Similarly, GSTP1 yielded two conjugates, 2-OHE(2)-1-SG and 2-OHE(2)-4-SG, from the corresponding quinone 2-hydroxyestradiol-quinone and one conjugate, 4-OHE(2)-2-SG, from 4-hydroxyestradiol-quinone.	2-hydroxyestradiol-quinone	105-131	glutathione S-transferase pi 1	Homo sapiens	11-16
15377160-6	2004	Similarly, GSTP1 yielded two conjugates, 2-OHE(2)-1-SG and 2-OHE(2)-4-SG, from the corresponding quinone 2-hydroxyestradiol-quinone and one conjugate, 4-OHE(2)-2-SG, from 4-hydroxyestradiol-quinone.	4-ohe	151-156	glutathione S-transferase pi 1	Homo sapiens	11-16
15377160-6	2004	Similarly, GSTP1 yielded two conjugates, 2-OHE(2)-1-SG and 2-OHE(2)-4-SG, from the corresponding quinone 2-hydroxyestradiol-quinone and one conjugate, 4-OHE(2)-2-SG, from 4-hydroxyestradiol-quinone.	4-hydroxyestradiol-quinone	171-197	glutathione S-transferase pi 1	Homo sapiens	11-16
15328171-2	2004	EXPERIMENTAL DESIGN: Genomic DNA sodium bisulfate converted from benign and malignant tissues was used as template in methyl-specific PCR for BRCA1, p16, ESR1, GSTP1, TRbeta1, RARbeta2, HIC1, APC, CCND2, and CDH1 genes.	sodium sulfate	33-49	glutathione S-transferase pi 1	Homo sapiens	160-165
15254763-1	2004	GSTP1, which encodes GSTPi, has a polymorphic site at codon 105 (exon 5), where an adenosine-to-guanine (A-G) transition causes an isoleucine-to-valine substitution (I105V).	adenosine-to-guanine	83-103	glutathione S-transferase pi 1	Homo sapiens	0-5
15254763-1	2004	GSTP1, which encodes GSTPi, has a polymorphic site at codon 105 (exon 5), where an adenosine-to-guanine (A-G) transition causes an isoleucine-to-valine substitution (I105V).	Isoleucine	131-141	glutathione S-transferase pi 1	Homo sapiens	0-5
15254763-1	2004	GSTP1, which encodes GSTPi, has a polymorphic site at codon 105 (exon 5), where an adenosine-to-guanine (A-G) transition causes an isoleucine-to-valine substitution (I105V).	Valine	145-151	glutathione S-transferase pi 1	Homo sapiens	0-5
15254763-3	2004	We hypothesized that head and neck squamous cell carcinoma (HNSCC) might respond differently to chemotherapeutic agents, especially cisplatin (CDDP) because of the presence of GSTP1 I105V polymorphism.	Cisplatin	132-141	glutathione S-transferase pi 1	Homo sapiens	176-181
15254763-3	2004	We hypothesized that head and neck squamous cell carcinoma (HNSCC) might respond differently to chemotherapeutic agents, especially cisplatin (CDDP) because of the presence of GSTP1 I105V polymorphism.	Cisplatin	143-147	glutathione S-transferase pi 1	Homo sapiens	176-181
15161912-10	2004	The addition of exogenous GSTP1-1 to HeLa-MRP1 vesicles resulted in GSH-dependent As(III) transport.	Glutathione	68-71	glutathione S-transferase pi 1	Homo sapiens	26-33
15213713-2	2004	Functional polymorphisms in DNA-repair genes XPD, ERCC1, XRCC1, XPA, and metabolising genes glutathione S-transferase GSTP1, GSTT1, GSTM1, and thymidylate synthase (TS) were assessed retrospectively in 106 patients with refractory stage IV disease who received 5-FU/oxaliplatin combination chemotherapy, using a polymerase chain reaction-based RFLP technique.	Fluorouracil	261-265	glutathione S-transferase pi 1	Homo sapiens	118-123
15213713-2	2004	Functional polymorphisms in DNA-repair genes XPD, ERCC1, XRCC1, XPA, and metabolising genes glutathione S-transferase GSTP1, GSTT1, GSTM1, and thymidylate synthase (TS) were assessed retrospectively in 106 patients with refractory stage IV disease who received 5-FU/oxaliplatin combination chemotherapy, using a polymerase chain reaction-based RFLP technique.	Oxaliplatin	266-277	glutathione S-transferase pi 1	Homo sapiens	118-123
15347473-0	2004	[Killing effect of adenovirus mediated fusion gene cytosine and deaminase uracil phosphoribosyl transferase directed by glutathione S-transferase P1 promoter on cisplatin-resistant ovarian cancer cells in vitro].	Cisplatin	161-170	glutathione S-transferase pi 1	Homo sapiens	120-148
15215328-0	2004	Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics.	Glutathione	17-28	glutathione S-transferase pi 1	Homo sapiens	61-66
15347473-1	2004	OBJECTIVE: To construct an adenoviral vector in which the fusion gene cytosine and uracil phosphoribosyl (UPP) transferase was directed by glutathione S-transferase P1 (GSTP1) promoter, and to investigate specific killing effect of the suicide gene system on cisplatin-resistant ovarian cancer cells.	Cisplatin	259-268	glutathione S-transferase pi 1	Homo sapiens	169-174
15347473-8	2004	CONCLUSION: Recombinant adenovirus carrying CD-UPP gene driven by GSTP1 promoter has a specific killing effect on cisplatin-resistant ovarian cancer cells.	Cisplatin	114-123	glutathione S-transferase pi 1	Homo sapiens	66-71
15126784-2	2004	The quantitative GSTP1 methylation assay, a recently developed methylation specific and polymerase chain reaction based technique, allows the accurate discrimination of benign prostate tissue and prostate cancer even in small, formalin fixed prostate needle biopsies.	Formaldehyde	227-235	glutathione S-transferase pi 1	Homo sapiens	17-22
15218992-7	2004	During combined analysis of genetic polymorphisms for mEPHX, GSTM1 and GSTP1, it was found that there are strong indicators for susceptibility to COPD (genotype combination with at least one mutant mEPHX exon-3 allele (histidine 113), GSTM1 null and homozygous for the GSTPI isoleucine 105 allele).	Histidine	219-228	glutathione S-transferase pi 1	Homo sapiens	71-76
14735473-4	2004	In contrast, frequencies of ile/ile genotype at codon 105 and variant val-ala haplotype of GSTP1 was significantly higher (OR = 1.5; 95% CI = 1.0-2.0) and lower (OR = 1.4; 95% CI = 1.0-1.9) in oral cancer patients compare to controls, respectively.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	91-96
15323418-0	2004	[The effects of cysteines on the function of human glutathion S-transferase pi(GSTp) under cell oxidative stress].	Cysteine	16-25	glutathione S-transferase pi 1	Homo sapiens	79-83
15323418-1	2004	Site-directed mutagenesis was used to generate three cysteine mutants of GSTp, C(47/101), C(14/47/101) and C(14/47/101/169).	Cysteine	53-61	glutathione S-transferase pi 1	Homo sapiens	73-77
15323418-3	2004	Data showed that each cysteine mutant inhibited endogenous GST catalyzatic activity and had remarkable dominant negative effect.	Cysteine	22-30	glutathione S-transferase pi 1	Homo sapiens	59-62
15323418-6	2004	These results suggest that cysteine residues of GSTp play an important role in protecting cells against oxitative stress.	Cysteine	27-35	glutathione S-transferase pi 1	Homo sapiens	48-52
15163523-0	2004	Assessment of DHPLC usefulness in the genotyping of GSTP1 exon 5 SNP: comparison to the PCR-RFLP method.	dhplc	14-19	glutathione S-transferase pi 1	Homo sapiens	52-57
15163523-3	2004	GSTP1 exon 5 gene presents a single-nucleotide polymorphism (a to g) that results into an amino-acid substitution (Ile to Val).	Isoleucine	115-118	glutathione S-transferase pi 1	Homo sapiens	0-5
15163523-3	2004	GSTP1 exon 5 gene presents a single-nucleotide polymorphism (a to g) that results into an amino-acid substitution (Ile to Val).	Valine	122-125	glutathione S-transferase pi 1	Homo sapiens	0-5
15041478-15	2004	Altogether, the present study reveals that a major site for flavonoid interaction with GSH-dependent toxicokinetics is the GS-X pump MRP1 rather than the conjugating GSTP1-1 activity itself.	Flavonoids	60-69	glutathione S-transferase pi 1	Homo sapiens	166-173
15041478-15	2004	Altogether, the present study reveals that a major site for flavonoid interaction with GSH-dependent toxicokinetics is the GS-X pump MRP1 rather than the conjugating GSTP1-1 activity itself.	Glutathione	87-90	glutathione S-transferase pi 1	Homo sapiens	166-173
15063315-1	2004	The purification and characterization of the buffalo liver microsomal transacetylase (TAase) catalyzing the transfer of acetyl groups from a model acetoxy drug: 7,8-diacetoxy-4-methylcoumarin (DAMC) to GST3-3 has been described here.	7,8-diacetoxy-4-methylcoumarin	161-191	glutathione S-transferase pi 1	Homo sapiens	202-208
15063315-8	2004	The subunit of control and modified GST3-3 were separated by SDS-polyacrylamide gel electrophoresis (PAGE) and digested with trypsin.	Sodium Dodecyl Sulfate	61-64	glutathione S-transferase pi 1	Homo sapiens	36-42
15063315-8	2004	The subunit of control and modified GST3-3 were separated by SDS-polyacrylamide gel electrophoresis (PAGE) and digested with trypsin.	polyacrylamide	65-79	glutathione S-transferase pi 1	Homo sapiens	36-42
15063315-13	2004	The mass value of each of them was 42 Da higher than the theoretical mass of a non-modified GST3-3 tryptic peptide, strongly suggesting acetylation.	Peptides	107-114	glutathione S-transferase pi 1	Homo sapiens	92-98
15013838-1	2004	Glutathione S-transferases (GSTs) play an important role in the protection of cells against xenobiotics and lipid hydroperoxides generated by oxidative stress.	Lipid Peroxides	108-128	glutathione S-transferase pi 1	Homo sapiens	28-32
15013838-3	2004	Reactive oxygen species are released at inflammation sites and oxidative stress conditions enhance the expression of genes encoding antioxidant enzymes such as GSTs.	Reactive Oxygen Species	0-23	glutathione S-transferase pi 1	Homo sapiens	160-164
14701855-7	2004	LA was 40 times less active than GSH in the inhibition of ONOOH-induced DHR-123 oxidation, whereas LA was 20 times more active than GSH in preventing the inhibition of GST-P1-1 by ONOOH.	Glutathione	132-135	glutathione S-transferase pi 1	Homo sapiens	168-176
14701855-7	2004	LA was 40 times less active than GSH in the inhibition of ONOOH-induced DHR-123 oxidation, whereas LA was 20 times more active than GSH in preventing the inhibition of GST-P1-1 by ONOOH.	onooh	180-185	glutathione S-transferase pi 1	Homo sapiens	168-176
14701855-8	2004	This points to different molecular mechanisms of ONOOH damage to DHR-123 compared with ONOOH damage to GST-P1-1.	onooh	87-92	glutathione S-transferase pi 1	Homo sapiens	103-111
14701855-10	2004	In the form of ONOOH toxicity involved in GST-P1-1 inhibition, LA is the most potent sulfur-containing antioxidant in our series.	onooh	15-20	glutathione S-transferase pi 1	Homo sapiens	42-50
14701855-10	2004	In the form of ONOOH toxicity involved in GST-P1-1 inhibition, LA is the most potent sulfur-containing antioxidant in our series.	Sulfur	85-91	glutathione S-transferase pi 1	Homo sapiens	42-50
14701855-12	2004	The high potency of LA to protect GST-P1-1 against ONOOH might be of therapeutic interest.	onooh	51-56	glutathione S-transferase pi 1	Homo sapiens	34-42
14676193-4	2004	The key residue, which is either Phe or Tyr (Tyr(50) in human GSTP1-1) in one subunit, is wedged into a hydrophobic pocket of the other subunit.	Phenylalanine	33-36	glutathione S-transferase pi 1	Homo sapiens	62-69
14676193-4	2004	The key residue, which is either Phe or Tyr (Tyr(50) in human GSTP1-1) in one subunit, is wedged into a hydrophobic pocket of the other subunit.	Tyrosine	40-43	glutathione S-transferase pi 1	Homo sapiens	62-69
14676193-4	2004	The key residue, which is either Phe or Tyr (Tyr(50) in human GSTP1-1) in one subunit, is wedged into a hydrophobic pocket of the other subunit.	Tyrosine	45-48	glutathione S-transferase pi 1	Homo sapiens	62-69
14676193-9	2004	A network of hydrogen-bonded water molecules, found in crystal structures of GSTP1-1, connects the two active sites and the main chain carbonyl group of Tyr(50), thereby offering a mechanism for communication between the two active sites.	Hydrogen	13-21	glutathione S-transferase pi 1	Homo sapiens	77-84
14676193-9	2004	A network of hydrogen-bonded water molecules, found in crystal structures of GSTP1-1, connects the two active sites and the main chain carbonyl group of Tyr(50), thereby offering a mechanism for communication between the two active sites.	Water	29-34	glutathione S-transferase pi 1	Homo sapiens	77-84
14676193-9	2004	A network of hydrogen-bonded water molecules, found in crystal structures of GSTP1-1, connects the two active sites and the main chain carbonyl group of Tyr(50), thereby offering a mechanism for communication between the two active sites.	Tyrosine	153-156	glutathione S-transferase pi 1	Homo sapiens	77-84
15041478-1	2004	The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5).	Flavonoids	207-217	glutathione S-transferase pi 1	Homo sapiens	135-142
15041478-1	2004	The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5).	Flavonoids	207-217	glutathione S-transferase pi 1	Homo sapiens	222-229
15041478-2	2004	The results reveal that GSTP1-1 activity in MCF7 pMTG5 cells can be inhibited by some flavonoids.	Flavonoids	86-96	glutathione S-transferase pi 1	Homo sapiens	24-31
15041478-4	2004	Other flavonoids like kaempferol, eriodictyol and quercetin showed a moderate GSTP1-1 inhibitory potential.	Flavonoids	6-16	glutathione S-transferase pi 1	Homo sapiens	78-85
15041478-4	2004	Other flavonoids like kaempferol, eriodictyol and quercetin showed a moderate GSTP1-1 inhibitory potential.	kaempferol	22-32	glutathione S-transferase pi 1	Homo sapiens	78-85
15041478-4	2004	Other flavonoids like kaempferol, eriodictyol and quercetin showed a moderate GSTP1-1 inhibitory potential.	eriodictyol	34-45	glutathione S-transferase pi 1	Homo sapiens	78-85
15041478-4	2004	Other flavonoids like kaempferol, eriodictyol and quercetin showed a moderate GSTP1-1 inhibitory potential.	Quercetin	50-59	glutathione S-transferase pi 1	Homo sapiens	78-85
14735473-4	2004	In contrast, frequencies of ile/ile genotype at codon 105 and variant val-ala haplotype of GSTP1 was significantly higher (OR = 1.5; 95% CI = 1.0-2.0) and lower (OR = 1.4; 95% CI = 1.0-1.9) in oral cancer patients compare to controls, respectively.	Alanine	74-77	glutathione S-transferase pi 1	Homo sapiens	91-96
14726165-9	2004	The I105 GSTP1 genotype was associated with an increase in IgE (120.3 U/mL [6.7-510.5] vs 27.7 U/mL [-1.5-60.6], p=0.03) and histamine (13.8 nmol/L [3.1-24.7] vs 5.2 nmol/L [-0.2-19.6], p=0.01) after challenge with diesel exhaust particles and allergens.	Histamine	125-134	glutathione S-transferase pi 1	Homo sapiens	9-14
14732228-0	2004	Glutathione S-transferase P1 has protective effects on cell viability against camptothecin.	Camptothecin	78-90	glutathione S-transferase pi 1	Homo sapiens	0-28
14732228-3	2004	We carried out transfection of GSTP1 sense and antisense vectors to examine effects of GSTP1 on cell cycle arrest and apoptosis induced by camptothecin in HeLa cells.	Camptothecin	139-151	glutathione S-transferase pi 1	Homo sapiens	87-92
14732228-5	2004	Camptothecin-induced S- or G2/M arrest was intensified by transfection of GSTP1 antisense vector, and subsequent apoptosis was attenuated by transfection of GSTP1 sense vector.	Camptothecin	0-12	glutathione S-transferase pi 1	Homo sapiens	74-79
14732228-5	2004	Camptothecin-induced S- or G2/M arrest was intensified by transfection of GSTP1 antisense vector, and subsequent apoptosis was attenuated by transfection of GSTP1 sense vector.	Camptothecin	0-12	glutathione S-transferase pi 1	Homo sapiens	157-162
14732228-6	2004	These results suggest that GSTP1 has protective effects against camptothecin-induced cytotoxicity.	Camptothecin	64-76	glutathione S-transferase pi 1	Homo sapiens	27-32
14751678-0	2004	Occupational exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1.	Styrene	25-32	glutathione S-transferase pi 1	Homo sapiens	170-175
15003890-12	2004	Inactivation of GSTP1 in gastric MALT lymphoma represents an additional mechanism favoring accumulation of reactive oxygen species and lymphomagenesis.	Reactive Oxygen Species	107-130	glutathione S-transferase pi 1	Homo sapiens	16-21
15141365-6	2004	In the present study, we have evaluated the effect of GSTM1, GSTT1, and GSTP1 polymorphisms on the frequency of MN and SCE induced by hydroquinone in human lymphocytes.	hydroquinone	134-146	glutathione S-transferase pi 1	Homo sapiens	72-77
14679015-6	2003	When CYP1B1 and GSTP1 were added together, the rate of conjugation was accelerated with a hyperbolic pattern of product formation in the order 4-OHE(2)-2-SG > 2-OHE(2)-4-SG >> 2-OHE(2)-1-SG.	4-ohe	143-148	glutathione S-transferase pi 1	Homo sapiens	16-21
14653739-4	2003	This mechanism is supported by the observation of multiphasic kinetics in the presence of high concentrations of hGSTP1-1 and the ability to trap kinetically competent exocyclic enones in aqueous acid using COMC-6 and COMC-7 as substrates.	exocyclic	168-177	glutathione S-transferase pi 1	Homo sapiens	113-121
14653739-4	2003	This mechanism is supported by the observation of multiphasic kinetics in the presence of high concentrations of hGSTP1-1 and the ability to trap kinetically competent exocyclic enones in aqueous acid using COMC-6 and COMC-7 as substrates.	enones	178-184	glutathione S-transferase pi 1	Homo sapiens	113-121
14653739-4	2003	This mechanism is supported by the observation of multiphasic kinetics in the presence of high concentrations of hGSTP1-1 and the ability to trap kinetically competent exocyclic enones in aqueous acid using COMC-6 and COMC-7 as substrates.	2-crotonyloxymethyl-2-cyclohexenone	207-213	glutathione S-transferase pi 1	Homo sapiens	113-121
14653739-4	2003	This mechanism is supported by the observation of multiphasic kinetics in the presence of high concentrations of hGSTP1-1 and the ability to trap kinetically competent exocyclic enones in aqueous acid using COMC-6 and COMC-7 as substrates.	comc-7	218-224	glutathione S-transferase pi 1	Homo sapiens	113-121
14653739-6	2003	The isozymes hGSTP1-1, hGSTA1-1, hGSTA4-4, and hGSTM2-2 catalyze the conversion of COMC-6 to final product with similar efficiencies (K(m) = 0.08-0.34 mM, k(cat) = 1.5-6.1 s(-)(1)); no activity was detected with the rat rGSTT2-2 isozyme.	2-crotonyloxymethyl-2-cyclohexenone	83-89	glutathione S-transferase pi 1	Homo sapiens	13-21
14679015-2	2003	The potential of the quinones to induce mutagenic DNA lesions is expected to be decreased by their conjugation with glutathione (GSH) either nonenzymatically or catalyzed by glutathione S-transferase P1 (GSTP1), a Phase II enzyme.	Quinones	21-29	glutathione S-transferase pi 1	Homo sapiens	174-202
14679015-2	2003	The potential of the quinones to induce mutagenic DNA lesions is expected to be decreased by their conjugation with glutathione (GSH) either nonenzymatically or catalyzed by glutathione S-transferase P1 (GSTP1), a Phase II enzyme.	Quinones	21-29	glutathione S-transferase pi 1	Homo sapiens	204-209
14679015-2	2003	The potential of the quinones to induce mutagenic DNA lesions is expected to be decreased by their conjugation with glutathione (GSH) either nonenzymatically or catalyzed by glutathione S-transferase P1 (GSTP1), a Phase II enzyme.	Glutathione	116-127	glutathione S-transferase pi 1	Homo sapiens	174-202
14679015-2	2003	The potential of the quinones to induce mutagenic DNA lesions is expected to be decreased by their conjugation with glutathione (GSH) either nonenzymatically or catalyzed by glutathione S-transferase P1 (GSTP1), a Phase II enzyme.	Glutathione	116-127	glutathione S-transferase pi 1	Homo sapiens	204-209
14679015-6	2003	When CYP1B1 and GSTP1 were added together, the rate of conjugation was accelerated with a hyperbolic pattern of product formation in the order 4-OHE(2)-2-SG > 2-OHE(2)-4-SG >> 2-OHE(2)-1-SG.	2-ohe	162-167	glutathione S-transferase pi 1	Homo sapiens	16-21
14679015-2	2003	The potential of the quinones to induce mutagenic DNA lesions is expected to be decreased by their conjugation with glutathione (GSH) either nonenzymatically or catalyzed by glutathione S-transferase P1 (GSTP1), a Phase II enzyme.	Glutathione	129-132	glutathione S-transferase pi 1	Homo sapiens	174-202
14679015-2	2003	The potential of the quinones to induce mutagenic DNA lesions is expected to be decreased by their conjugation with glutathione (GSH) either nonenzymatically or catalyzed by glutathione S-transferase P1 (GSTP1), a Phase II enzyme.	Glutathione	129-132	glutathione S-transferase pi 1	Homo sapiens	204-209
14679015-6	2003	When CYP1B1 and GSTP1 were added together, the rate of conjugation was accelerated with a hyperbolic pattern of product formation in the order 4-OHE(2)-2-SG > 2-OHE(2)-4-SG >> 2-OHE(2)-1-SG.	2-ohe	185-190	glutathione S-transferase pi 1	Homo sapiens	16-21
14679015-7	2003	Incubation of E(2) with CYP1B1 and GSTP1 resulted in the formation of 4-OHE(2), 2-OHE(2), 4-OHE(2)-2-SG, 2-OHE(2)-4-SG, and 2-OHE(2)-1-SG.	4-ohe	70-75	glutathione S-transferase pi 1	Homo sapiens	35-40
14679015-7	2003	Incubation of E(2) with CYP1B1 and GSTP1 resulted in the formation of 4-OHE(2), 2-OHE(2), 4-OHE(2)-2-SG, 2-OHE(2)-4-SG, and 2-OHE(2)-1-SG.	2-ohe	80-85	glutathione S-transferase pi 1	Homo sapiens	35-40
14679015-7	2003	Incubation of E(2) with CYP1B1 and GSTP1 resulted in the formation of 4-OHE(2), 2-OHE(2), 4-OHE(2)-2-SG, 2-OHE(2)-4-SG, and 2-OHE(2)-1-SG.	4-ohe	90-95	glutathione S-transferase pi 1	Homo sapiens	35-40
14679015-7	2003	Incubation of E(2) with CYP1B1 and GSTP1 resulted in the formation of 4-OHE(2), 2-OHE(2), 4-OHE(2)-2-SG, 2-OHE(2)-4-SG, and 2-OHE(2)-1-SG.	2-ohe	105-110	glutathione S-transferase pi 1	Homo sapiens	35-40
14679015-7	2003	Incubation of E(2) with CYP1B1 and GSTP1 resulted in the formation of 4-OHE(2), 2-OHE(2), 4-OHE(2)-2-SG, 2-OHE(2)-4-SG, and 2-OHE(2)-1-SG.	2-ohe	105-110	glutathione S-transferase pi 1	Homo sapiens	35-40
14679015-8	2003	The production of GSH-estrogen conjugates was dependent on the concentrations of E(2) and GSTP1 but overall yielded only one-tenth of the catechol estrogen production.	Glutathione	18-21	glutathione S-transferase pi 1	Homo sapiens	90-95
14679015-9	2003	The concentration gap between catechol estrogens and GSH-estrogen conjugates may result from nonenzymatic reaction of the labile quinones with other nucleophiles besides GSH or may reflect the lower efficiency of GSTP1 compared with CYP1B1.	catechol	30-38	glutathione S-transferase pi 1	Homo sapiens	213-218
14679015-9	2003	The concentration gap between catechol estrogens and GSH-estrogen conjugates may result from nonenzymatic reaction of the labile quinones with other nucleophiles besides GSH or may reflect the lower efficiency of GSTP1 compared with CYP1B1.	Glutathione	53-56	glutathione S-transferase pi 1	Homo sapiens	213-218
14623254-1	2003	Glutathione S-transferase P1-1 (GSTP1-1) conjugates glutathione to electrophilic compounds and its expression is correlated to chemotherapeutic drug resistance.	Glutathione	52-63	glutathione S-transferase pi 1	Homo sapiens	32-39
14623254-2	2003	Results show that GSTP1-1 mRNA as well as protein expressions are increased during Aclarubicin (Acla)- and Doxorubicin (Dox)-induced erythroid differentiation of human K562 cells.	Aclarubicin	83-94	glutathione S-transferase pi 1	Homo sapiens	18-25
14623254-2	2003	Results show that GSTP1-1 mRNA as well as protein expressions are increased during Aclarubicin (Acla)- and Doxorubicin (Dox)-induced erythroid differentiation of human K562 cells.	Aclarubicin	83-87	glutathione S-transferase pi 1	Homo sapiens	18-25
14623254-2	2003	Results show that GSTP1-1 mRNA as well as protein expressions are increased during Aclarubicin (Acla)- and Doxorubicin (Dox)-induced erythroid differentiation of human K562 cells.	Doxorubicin	107-118	glutathione S-transferase pi 1	Homo sapiens	18-25
14623254-2	2003	Results show that GSTP1-1 mRNA as well as protein expressions are increased during Aclarubicin (Acla)- and Doxorubicin (Dox)-induced erythroid differentiation of human K562 cells.	Doxorubicin	107-110	glutathione S-transferase pi 1	Homo sapiens	18-25
14623254-3	2003	In contrast, during megakaryocytic differentiation by 12-O-tetradecanoyl phorbol 13-acetate (TPA), GSTP1-1 expression decreased at both mRNA and protein levels.	Tetradecanoylphorbol Acetate	54-91	glutathione S-transferase pi 1	Homo sapiens	99-106
14623254-3	2003	In contrast, during megakaryocytic differentiation by 12-O-tetradecanoyl phorbol 13-acetate (TPA), GSTP1-1 expression decreased at both mRNA and protein levels.	Tetradecanoylphorbol Acetate	93-96	glutathione S-transferase pi 1	Homo sapiens	99-106
14556662-8	2003	Mitogen-activated protein kinase (MAPK) kinase (MEK) 1, extracellular signal-regulated kinase (ERK) 1 and GST P1-1 were increased in cells treated with 25-75 microM EA, while c-Jun N-terminal kinase (JNK) 1 and p38 MAPK were markedly decreased by 100 microM EA.	Ethacrynic Acid	165-167	glutathione S-transferase pi 1	Homo sapiens	106-112
12937169-1	2003	The thermodynamics of binding of both the substrate glutathione (GSH) and the competitive inhibitor S-hexylglutathione to the mutant Y49F of human glutathione S-transferase (hGST P1-1), a key residue at the dimer interface, has been investigated by isothermal titration calorimetry and fluorescence spectroscopy.	Glutathione	52-63	glutathione S-transferase pi 1	Homo sapiens	174-183
12937169-1	2003	The thermodynamics of binding of both the substrate glutathione (GSH) and the competitive inhibitor S-hexylglutathione to the mutant Y49F of human glutathione S-transferase (hGST P1-1), a key residue at the dimer interface, has been investigated by isothermal titration calorimetry and fluorescence spectroscopy.	Glutathione	65-68	glutathione S-transferase pi 1	Homo sapiens	174-183
12937169-1	2003	The thermodynamics of binding of both the substrate glutathione (GSH) and the competitive inhibitor S-hexylglutathione to the mutant Y49F of human glutathione S-transferase (hGST P1-1), a key residue at the dimer interface, has been investigated by isothermal titration calorimetry and fluorescence spectroscopy.	hexylglutathione	100-118	glutathione S-transferase pi 1	Homo sapiens	174-183
12871945-1	2003	The interaction of dinitrosyl-diglutathionyl-iron complex (DNDGIC), a natural carrier of nitric oxide, with representative members of the human glutathione transferase (GST) superfamily, i.e. GSTA1-1, GSTM2-2, GSTP1-1, and GSTT2-2, has been investigated by means of pre-steady and steady state kinetics, fluorometry, electron paramagnetic resonance, and radiometric experiments.	dinitrosyl diglutathionyl iron	19-49	glutathione S-transferase pi 1	Homo sapiens	210-217
14555224-3	2003	In the present study, we examined the inhibitory effect of curcumin on the expression of GSTP1-1 mRNA as well as protein, and we correlated this inhibition with the apoptotic effect of curcumin on K562 leukemia cells.	Curcumin	59-67	glutathione S-transferase pi 1	Homo sapiens	89-96
14555224-3	2003	In the present study, we examined the inhibitory effect of curcumin on the expression of GSTP1-1 mRNA as well as protein, and we correlated this inhibition with the apoptotic effect of curcumin on K562 leukemia cells.	Curcumin	185-193	glutathione S-transferase pi 1	Homo sapiens	89-96
14555224-4	2003	Curcumin efficiently inhibited the tumour necrosis factor alpha- and phorbol ester-induced binding of AP-1 and NF-kappaB transcription factors to sites located on the GSTP1-1 gene promoter.	Curcumin	0-8	glutathione S-transferase pi 1	Homo sapiens	167-174
14555224-4	2003	Curcumin efficiently inhibited the tumour necrosis factor alpha- and phorbol ester-induced binding of AP-1 and NF-kappaB transcription factors to sites located on the GSTP1-1 gene promoter.	Phorbol Esters	69-82	glutathione S-transferase pi 1	Homo sapiens	167-174
14555224-5	2003	TNFalpha-induced GSTP1-1 promoter activity was also inhibited by curcumin as shown by reporter gene assay.	Curcumin	65-73	glutathione S-transferase pi 1	Homo sapiens	17-24
14555224-7	2003	Our results overall add a novel role for curcumin as this chemoprotective compound could contribute to induce apoptosis by its ability to inhibit the GSTP1-1 expression at the level of transcription.	Curcumin	41-49	glutathione S-transferase pi 1	Homo sapiens	150-157
12896903-3	2003	Of these, butyrate induces GSTP1 protein expression and GST activity in the human colon tumor cell line HT29.	Butyrates	10-18	glutathione S-transferase pi 1	Homo sapiens	27-32
12896903-9	2003	In HT29, butyrate significantly enhanced GSTA1/2 (3.5-fold), GSTM2 (not detectable in controls), GSTP1 (1.5-fold) and GST activity (1.4-fold), but not GSTM1 or GSTT1.	Butyrates	9-17	glutathione S-transferase pi 1	Homo sapiens	97-102
12805482-2	2003	This study examines whether glutathione S-transferase-pi (GSTP1-1) is involved in resistance to anticancer drugs in cholangiocarcinoma and whether GSTP1-1-specific inhibitors can overcome this resistance.	Glutathione	28-39	glutathione S-transferase pi 1	Homo sapiens	58-65
12950168-5	2003	Moreover, within the bis-glutathionyl series, a 10-fold increase in selectivity was achieved for GST P1-1 over the A1-1 isoform.	bis-glutathionyl	21-37	glutathione S-transferase pi 1	Homo sapiens	97-105
12937133-1	2003	Somatic inactivation of the glutathione S-transferase-pi gene (GSTP1) via CpG island hypermethylation occurs early during prostate carcinogenesis, present in approximately 70% of high-grade prostatic intraepithelial neoplasia (high-grade PIN) lesions and more than 90% of adenocarcinomas.	Glutathione	28-39	glutathione S-transferase pi 1	Homo sapiens	63-68
13679171-3	2003	In order to further investigate the effect of the isosteric substitution on the binding abilities of the new GSH analogues 4, 5 and 9, the previously reported cysteinyl-containing analogue H-Glo(-Cys-Gly-OH)-OH has been also evaluated as a co-substrate for hGSTP1-1.	Glutathione	109-112	glutathione S-transferase pi 1	Homo sapiens	257-265
13679171-3	2003	In order to further investigate the effect of the isosteric substitution on the binding abilities of the new GSH analogues 4, 5 and 9, the previously reported cysteinyl-containing analogue H-Glo(-Cys-Gly-OH)-OH has been also evaluated as a co-substrate for hGSTP1-1.	h-glo(-cys-gly-oh)-oh	189-210	glutathione S-transferase pi 1	Homo sapiens	257-265
12805482-4	2003	Transfection of the GSTP1-1 antisense expression vector into a human cholangiocarcinoma cell line (HuCCT1) apparently decreased its intracellular GSTP1-1 concentration, and the sensitivity of transfectants to adriamycin (ADR), cisplatin, and alkylating agents such as melphalan and 4-hydroxyperoxycyclophosphamide (4-HC) was increased significantly, compared with that of mock transfectants.	Doxorubicin	209-219	glutathione S-transferase pi 1	Homo sapiens	20-27
12805482-4	2003	Transfection of the GSTP1-1 antisense expression vector into a human cholangiocarcinoma cell line (HuCCT1) apparently decreased its intracellular GSTP1-1 concentration, and the sensitivity of transfectants to adriamycin (ADR), cisplatin, and alkylating agents such as melphalan and 4-hydroxyperoxycyclophosphamide (4-HC) was increased significantly, compared with that of mock transfectants.	Cisplatin	227-236	glutathione S-transferase pi 1	Homo sapiens	20-27
12805482-4	2003	Transfection of the GSTP1-1 antisense expression vector into a human cholangiocarcinoma cell line (HuCCT1) apparently decreased its intracellular GSTP1-1 concentration, and the sensitivity of transfectants to adriamycin (ADR), cisplatin, and alkylating agents such as melphalan and 4-hydroxyperoxycyclophosphamide (4-HC) was increased significantly, compared with that of mock transfectants.	Melphalan	268-277	glutathione S-transferase pi 1	Homo sapiens	20-27
12805482-4	2003	Transfection of the GSTP1-1 antisense expression vector into a human cholangiocarcinoma cell line (HuCCT1) apparently decreased its intracellular GSTP1-1 concentration, and the sensitivity of transfectants to adriamycin (ADR), cisplatin, and alkylating agents such as melphalan and 4-hydroxyperoxycyclophosphamide (4-HC) was increased significantly, compared with that of mock transfectants.	4-hydroxyperoxycyclophosphamide	282-313	glutathione S-transferase pi 1	Homo sapiens	20-27
12805482-4	2003	Transfection of the GSTP1-1 antisense expression vector into a human cholangiocarcinoma cell line (HuCCT1) apparently decreased its intracellular GSTP1-1 concentration, and the sensitivity of transfectants to adriamycin (ADR), cisplatin, and alkylating agents such as melphalan and 4-hydroxyperoxycyclophosphamide (4-HC) was increased significantly, compared with that of mock transfectants.	4-hydroxyperoxycyclophosphamide	315-319	glutathione S-transferase pi 1	Homo sapiens	20-27
12805482-5	2003	We next synthesized GSTP1-1-specific inhibitors by elongating the carbon chain of the ethylester at the N-terminal of gamma-glutamyl-S-benzylcysteinyl-phenylglycyl diethylester and performed a pharmacokinetic study on them.	Carbon	66-72	glutathione S-transferase pi 1	Homo sapiens	20-27
12805482-5	2003	We next synthesized GSTP1-1-specific inhibitors by elongating the carbon chain of the ethylester at the N-terminal of gamma-glutamyl-S-benzylcysteinyl-phenylglycyl diethylester and performed a pharmacokinetic study on them.	gamma-glutamyl-s	118-134	glutathione S-transferase pi 1	Homo sapiens	20-27
12805482-5	2003	We next synthesized GSTP1-1-specific inhibitors by elongating the carbon chain of the ethylester at the N-terminal of gamma-glutamyl-S-benzylcysteinyl-phenylglycyl diethylester and performed a pharmacokinetic study on them.	benzylcysteinyl	135-150	glutathione S-transferase pi 1	Homo sapiens	20-27
12805482-6	2003	Of six GSTP1-1 inhibitors tested, O1-hexadecyl-gamma-glutamyl-S-benzylcysteinyl-d-phenylglycine ethylester (C16C2) showed the smallest volume of central compartment and smallest volume of distribution at steady state and the second smallest clearance, being the most effective inhibitor in vivo.	o1-hexadecyl-gamma-glutamyl-s-benzylcysteinyl-d-phenylglycine ethylester	34-106	glutathione S-transferase pi 1	Homo sapiens	7-14
12960130-5	2003	Sodium bisulfite-modified DNA was amplified by methyl-specific PCR (MSP) for CDH1, GSTP1, BRCA1, and RARbeta to detect gene promoter CpG island methylation.	sodium bisulfite	0-16	glutathione S-transferase pi 1	Homo sapiens	83-88
12914384-6	2003	XRCC1 (X-ray cross-complementing group 1), ERCC1 (excision cross-complementing gene) and GSTP1 (glutathione S-transferase) have a role in the development of pharmacoresistance to platinum derivatives.	Platinum	179-187	glutathione S-transferase pi 1	Homo sapiens	89-94
12781783-6	2003	The hydrolysis of the thiol ester of E-SG was studied further with GSTA1-1 and GSTP1-1, as a model pro-drug with several possible fates for the hydrolysis products: competitive inhibition, covalent enzyme adduction, and sequential metabolism.	thiol ester	22-33	glutathione S-transferase pi 1	Homo sapiens	79-86
12835616-0	2003	GSTP1 A1578G (Ile105Val) polymorphism in benzidine-exposed workers: an association with cytological grading of exfoliated urothelial cells.	ile105val	14-23	glutathione S-transferase pi 1	Homo sapiens	0-5
12835616-0	2003	GSTP1 A1578G (Ile105Val) polymorphism in benzidine-exposed workers: an association with cytological grading of exfoliated urothelial cells.	benzidine	41-50	glutathione S-transferase pi 1	Homo sapiens	0-5
12835616-6	2003	These findings show for the first time an association between the GSTP1 AG or GG genotype and higher cytological gradings of exfoliated urothelial cells from formerly benzidine-exposed workers.	benzidine	167-176	glutathione S-transferase pi 1	Homo sapiens	66-71
12781202-2	2003	It is for instance known that RRR-alpha-tocopherol inhibits GST P1-1 [Haaften van R.I.M.	alpha-Tocopherol	34-50	glutathione S-transferase pi 1	Homo sapiens	60-68
12814998-5	2003	Genotype at the GSTP1 Ile(105)Val substitution was determined by PCR and oligonucleotide ligation assay.	Oligonucleotides	73-88	glutathione S-transferase pi 1	Homo sapiens	16-21
12781202-9	2003	It also appeared that the purified GST P1-1 isoenzyme is non-competitively inhibited by RRR-alpha-tocopherol.	alpha-Tocopherol	92-108	glutathione S-transferase pi 1	Homo sapiens	35-43
12781202-12	2003	However, the inhibition of GSTs by RRR-alpha-tocopherol can still be of physiological relevance, because due to dermal application of cosmetic products very high concentrations vitamin E can be reached in the skin, where GST P1-1 is present.	alpha-Tocopherol	39-55	glutathione S-transferase pi 1	Homo sapiens	27-31
12781202-12	2003	However, the inhibition of GSTs by RRR-alpha-tocopherol can still be of physiological relevance, because due to dermal application of cosmetic products very high concentrations vitamin E can be reached in the skin, where GST P1-1 is present.	alpha-Tocopherol	39-55	glutathione S-transferase pi 1	Homo sapiens	221-229
12781202-12	2003	However, the inhibition of GSTs by RRR-alpha-tocopherol can still be of physiological relevance, because due to dermal application of cosmetic products very high concentrations vitamin E can be reached in the skin, where GST P1-1 is present.	Vitamin E	177-186	glutathione S-transferase pi 1	Homo sapiens	27-31
12781202-12	2003	However, the inhibition of GSTs by RRR-alpha-tocopherol can still be of physiological relevance, because due to dermal application of cosmetic products very high concentrations vitamin E can be reached in the skin, where GST P1-1 is present.	Vitamin E	177-186	glutathione S-transferase pi 1	Homo sapiens	221-229
12686490-2	2003	The results show a time- and concentration-dependent inhibition of GSTP1-1 by quercetin.	Quercetin	78-87	glutathione S-transferase pi 1	Homo sapiens	67-74
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	77-86	glutathione S-transferase pi 1	Homo sapiens	0-7
12686490-1	2003	In the present study, the inhibition of human glutathione S-transferase P1-1 (GSTP1-1) by the flavonoid quercetin has been investigated.	Flavonoids	94-103	glutathione S-transferase pi 1	Homo sapiens	78-85
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	120-129	glutathione S-transferase pi 1	Homo sapiens	0-7
12686490-1	2003	In the present study, the inhibition of human glutathione S-transferase P1-1 (GSTP1-1) by the flavonoid quercetin has been investigated.	Quercetin	104-113	glutathione S-transferase pi 1	Homo sapiens	78-85
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	120-129	glutathione S-transferase pi 1	Homo sapiens	173-180
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	120-129	glutathione S-transferase pi 1	Homo sapiens	0-7
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	120-129	glutathione S-transferase pi 1	Homo sapiens	173-180
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Ascorbic Acid	382-395	glutathione S-transferase pi 1	Homo sapiens	0-7
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Glutathione	399-410	glutathione S-transferase pi 1	Homo sapiens	0-7
12686490-4	2003	Addition of glutathione upon complete inactivation of GSTP1-1 partially restores the activity.	Glutathione	12-23	glutathione S-transferase pi 1	Homo sapiens	54-61
12686490-5	2003	Inhibition studies with the GSTP1-1 mutants C47S, C101S and the double mutant C47S/C101S showed that cysteine 47 is the key residue in the interaction between quercetin and GSTP1-1.	Cysteine	101-109	glutathione S-transferase pi 1	Homo sapiens	28-35
12686490-5	2003	Inhibition studies with the GSTP1-1 mutants C47S, C101S and the double mutant C47S/C101S showed that cysteine 47 is the key residue in the interaction between quercetin and GSTP1-1.	Cysteine	101-109	glutathione S-transferase pi 1	Homo sapiens	173-180
12686490-5	2003	Inhibition studies with the GSTP1-1 mutants C47S, C101S and the double mutant C47S/C101S showed that cysteine 47 is the key residue in the interaction between quercetin and GSTP1-1.	Quercetin	159-168	glutathione S-transferase pi 1	Homo sapiens	28-35
12686490-5	2003	Inhibition studies with the GSTP1-1 mutants C47S, C101S and the double mutant C47S/C101S showed that cysteine 47 is the key residue in the interaction between quercetin and GSTP1-1.	Quercetin	159-168	glutathione S-transferase pi 1	Homo sapiens	173-180
12686490-6	2003	HPLC and LC-MS analysis of trypsin digested GSTP1-1 inhibited by quercetin did not show formation of a covalent bond between Cys 47 residue of the peptide fragment 45-54 and quercetin.	Quercetin	65-74	glutathione S-transferase pi 1	Homo sapiens	44-51
12686490-8	2003	Nevertheless, the results of the present study indicate that quinone-type oxidation products of quercetin likely act as specific active site inhibitors of GSTP1-1 by binding to cysteine 47.	quinone	61-68	glutathione S-transferase pi 1	Homo sapiens	155-162
12686490-8	2003	Nevertheless, the results of the present study indicate that quinone-type oxidation products of quercetin likely act as specific active site inhibitors of GSTP1-1 by binding to cysteine 47.	Quercetin	96-105	glutathione S-transferase pi 1	Homo sapiens	155-162
12686490-8	2003	Nevertheless, the results of the present study indicate that quinone-type oxidation products of quercetin likely act as specific active site inhibitors of GSTP1-1 by binding to cysteine 47.	Cysteine	177-185	glutathione S-transferase pi 1	Homo sapiens	155-162
12868187-1	2003	The aim of the study was an assessment of various risk factors for nephrotoxicity of ifosfamide (IF) in children taking into account the importance of the concentrations of toxic metabolites of the drug excreted with urine and the polymorphism of genes encoding S-glutathione transferases of mi, pi, and theta classes (GSTM1, GSTP1 and GSTT1).	Ifosfamide	85-95	glutathione S-transferase pi 1	Homo sapiens	326-331
12680784-7	2003	Thus, we conclude that an electrophilic quinone oxidation product that reacts with intracellular nucleophiles including protein thiol or GSH plays a major role in the GSTP1 gene expression.	Sulfhydryl Compounds	128-133	glutathione S-transferase pi 1	Homo sapiens	167-172
12680784-7	2003	Thus, we conclude that an electrophilic quinone oxidation product that reacts with intracellular nucleophiles including protein thiol or GSH plays a major role in the GSTP1 gene expression.	Glutathione	137-140	glutathione S-transferase pi 1	Homo sapiens	167-172
12660004-1	2003	Glutathione transferases (GSTs), a multiple gene family of phase II enzymes, catalyze detoxifying endogenous reactions with glutathione and protect cellular macromolecules from damage caused by cytotoxic and carcinogenic agents.	Glutathione	124-135	glutathione S-transferase pi 1	Homo sapiens	26-30
12660004-2	2003	Glutathione S-transferase p1 (GSTP1), the most abundant GST isoform in the lung, metabolizes numerous carcinogenic compounds including benzo[a]pyrene, a tobacco carcinogen.	Benzo(a)pyrene	135-149	glutathione S-transferase pi 1	Homo sapiens	30-35
12680784-5	2003	The data were consistent with the observation that tBHQ more potently induced the GSTP1 gene expression in RL34 cells than DtBHQ did.	2-tert-butylhydroquinone	51-55	glutathione S-transferase pi 1	Homo sapiens	82-87
12680784-7	2003	Thus, we conclude that an electrophilic quinone oxidation product that reacts with intracellular nucleophiles including protein thiol or GSH plays a major role in the GSTP1 gene expression.	quinone	40-47	glutathione S-transferase pi 1	Homo sapiens	167-172
12604177-5	2003	The results obtained suggest that CYP1A1 m1, m2 and m4, CYP2E1 Dra I and GSTP1 (exons 5 and 6) polymorphisms may affect styrene induction of DNA damage in human leukocytes.	Styrene	120-127	glutathione S-transferase pi 1	Homo sapiens	73-78
12868187-6	2003	The analysis performed demonstrated that in children with GSTP1 gene A-G codon 105 transition, a statistically significantly (p = 0.01) higher urinary excretion of toxic ifosfamide metabolites occurred, that increased with the cumulative drug dose.	Ifosfamide	170-180	glutathione S-transferase pi 1	Homo sapiens	58-63
12868187-8	2003	The results of the studies demonstrate that GSTP1 gene mutations are the genetic risk factor for nephrotoxic complications of ifosfamide use.	Ifosfamide	126-136	glutathione S-transferase pi 1	Homo sapiens	44-49
12414796-1	2003	In human glutathione transferase P1-1 (hGSTP1-1) position 146 is occupied by a glycine residue, which is located in a bend of a long loop that together with the alpha6-helix forms a substructure (GST motif II) maintained in all soluble GSTs.	Glycine	79-86	glutathione S-transferase pi 1	Homo sapiens	39-47
12775499-4	2003	Genotypes of glutathione S-transferase M1 and P1 (GSTM1 and GSTP1), enzymes involved in the detoxification of PAH metabolites, were determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism, respectively.	Polycyclic Aromatic Hydrocarbons	110-113	glutathione S-transferase pi 1	Homo sapiens	60-65
12543808-2	2003	We report here thathypermethylation of CpG dinucleotides at the 5" transcriptional regulatory region was sufficient to inhibit GSTP1 transcription in MCF-7 breast cancer cells and that repression of GSTP1 transcription was mediated in part by the methyl-CpG-binding domain (MBD) protein MBD2.	cytidylyl-3'-5'-guanosine	39-56	glutathione S-transferase pi 1	Homo sapiens	127-132
12543808-2	2003	We report here thathypermethylation of CpG dinucleotides at the 5" transcriptional regulatory region was sufficient to inhibit GSTP1 transcription in MCF-7 breast cancer cells and that repression of GSTP1 transcription was mediated in part by the methyl-CpG-binding domain (MBD) protein MBD2.	cytidylyl-3'-5'-guanosine	39-56	glutathione S-transferase pi 1	Homo sapiens	199-204
12563680-2	2003	The glutathione S-transferase (GST) genes GSTM1, GSTT1, and GSTP1 catalyze metabolic pathways for the excretion of reactive oxygen species that may be generated by cellular oxidative stress induced by ultraviolet radiation in sunlight.	Reactive Oxygen Species	115-138	glutathione S-transferase pi 1	Homo sapiens	60-65
12540498-6	2003	The GSTP1 105 Val/Val genotype was associated with increased glioma incidence [odds ratio (OR), 1.8; 95% confidence limits (CLs), 1.2, 2.7], with the estimated effect following a trend of increasing magnitude by number of variant alleles (Ile/Ile: OR, 1.0; Ile/Val: OR, 1.3; Val/Val: OR, 2.1).	calusterone	124-127	glutathione S-transferase pi 1	Homo sapiens	4-9
12500666-8	2002	An overrepresentation of GSTP1 AG or GG genotype corresponding a less stable and less effective isozyme protein was detected in patients with benzidine related occupational bladder cancer, compared with that in the normal population though a statistical significance was not yet reached (P = 0.09, OR = 1.96, 95% CI 0.89-4.32).	benzidine	142-151	glutathione S-transferase pi 1	Homo sapiens	25-30
12448005-5	2002	Bisulfite-modified DNA was examined for gene promoter hypermethylation in DAP-kinase, E-cadherin, GSTP1, p14, p15, p16, RASSF1A and hMLH1 by methylation-specific-PCR.	hydrogen sulfite	0-9	glutathione S-transferase pi 1	Homo sapiens	98-103
12387881-2	2002	We have discovered a membrane-bound enzyme catalyzing the transfer of acetyl groups from the acetyl donor 7,8-diacetoxy-4-methyl coumarin (DAMC) to glutathione S-transferase 3-3 (GST3-3), termed DAMC:protein transacetylase (TAase).	7,8-diacetoxy-4-methylcoumarin	106-137	glutathione S-transferase pi 1	Homo sapiens	148-185
12500666-11	2002	GSTP1 AG or GG genotype has a higher frequency in the patients with benzidine related occupational bladder cancer, and further work is needed to confirm if GSTP1 AG or GG genotype plays a role in the development of occupational bladder cancer.	benzidine	68-77	glutathione S-transferase pi 1	Homo sapiens	0-5
12440523-3	2002	Previously, we found that tocopherols and diverse tocopherol derivatives can inhibit the activity of human glutathione S-transferase P1-1 (GST P1-1).	Tocopherols	26-37	glutathione S-transferase pi 1	Homo sapiens	139-147
12440523-3	2002	Previously, we found that tocopherols and diverse tocopherol derivatives can inhibit the activity of human glutathione S-transferase P1-1 (GST P1-1).	Tocopherols	26-36	glutathione S-transferase pi 1	Homo sapiens	139-147
12440523-4	2002	In this study we found that GST P1-1 is also inhibited, in a concentration-dependent manner, by alpha- and gamma-tocotrienol.	alpha- and gamma-tocotrienol	96-124	glutathione S-transferase pi 1	Homo sapiens	28-36
12440523-5	2002	The concentration giving 50% inhibition of GST P1-1 is 1.8 +/- 0.1 microM for alpha-tocotrienol and 0.7 +/- 0.1 microM for gamma-tocotrienol.	tocotrienol, alpha	78-95	glutathione S-transferase pi 1	Homo sapiens	43-51
12440523-5	2002	The concentration giving 50% inhibition of GST P1-1 is 1.8 +/- 0.1 microM for alpha-tocotrienol and 0.7 +/- 0.1 microM for gamma-tocotrienol.	plastochromanol 8	123-140	glutathione S-transferase pi 1	Homo sapiens	43-51
12440523-6	2002	This inhibition of GST P1-1 is noncompetitive with respect to both substrates CDNB and GSH.	Dinitrochlorobenzene	78-82	glutathione S-transferase pi 1	Homo sapiens	19-27
12440523-6	2002	This inhibition of GST P1-1 is noncompetitive with respect to both substrates CDNB and GSH.	Glutathione	87-90	glutathione S-transferase pi 1	Homo sapiens	19-27
12440523-7	2002	We also examined the 3D structure of GST P1-1 for a possible tocopherol/tocotrienol binding site.	Tocopherols	61-71	glutathione S-transferase pi 1	Homo sapiens	37-45
12440523-7	2002	We also examined the 3D structure of GST P1-1 for a possible tocopherol/tocotrienol binding site.	Tocotrienols	72-83	glutathione S-transferase pi 1	Homo sapiens	37-45
12119004-1	2002	Glutathione S-transferases (GSTs) are a family of detoxification isozymes that protect cells by conjugating GSH to a variety of toxic compounds, and they may also play a role in the regulation of both cellular proliferation and apoptosis.	Glutathione	108-111	glutathione S-transferase pi 1	Homo sapiens	28-32
12119004-2	2002	We have previously shown that human GST P1-1, which is the most widely distributed extrahepatic isozyme, could be inactivated by the catechol estrogen metabolite 4-hydroxyequilenin (4-OHEN) in vitro [Chang, M., Shin, Y. G., van Breemen, R. B., Blond, S. Y., and Bolton, J. L. (2001) Biochemistry 40, 4811-4820].	catechol	133-141	glutathione S-transferase pi 1	Homo sapiens	36-44
12119004-2	2002	We have previously shown that human GST P1-1, which is the most widely distributed extrahepatic isozyme, could be inactivated by the catechol estrogen metabolite 4-hydroxyequilenin (4-OHEN) in vitro [Chang, M., Shin, Y. G., van Breemen, R. B., Blond, S. Y., and Bolton, J. L. (2001) Biochemistry 40, 4811-4820].	4-hydroxy-equilenin	162-180	glutathione S-transferase pi 1	Homo sapiens	36-44
12119004-2	2002	We have previously shown that human GST P1-1, which is the most widely distributed extrahepatic isozyme, could be inactivated by the catechol estrogen metabolite 4-hydroxyequilenin (4-OHEN) in vitro [Chang, M., Shin, Y. G., van Breemen, R. B., Blond, S. Y., and Bolton, J. L. (2001) Biochemistry 40, 4811-4820].	4-ohen	182-188	glutathione S-transferase pi 1	Homo sapiens	36-44
12119004-4	2002	In addition, 4-OHEN caused significant decreases in GST activity in nontransformed human breast epithelial cells (MCF-10A) but not in the human hepatoma HepG2 cells, which lack GST P1-1.	4-ohen	13-19	glutathione S-transferase pi 1	Homo sapiens	177-185
12119004-5	2002	We also showed that GSH partially protected the inactivation of GST P1-1 by 4-OHEN in vitro, and depletion of cellular GSH enhanced the 4-OHEN-induced inhibition of GST activity.	Glutathione	20-23	glutathione S-transferase pi 1	Homo sapiens	64-70
12119004-5	2002	We also showed that GSH partially protected the inactivation of GST P1-1 by 4-OHEN in vitro, and depletion of cellular GSH enhanced the 4-OHEN-induced inhibition of GST activity.	4-ohen	76-82	glutathione S-transferase pi 1	Homo sapiens	64-70
12119004-6	2002	In addition, 4-OHEN GSH conjugates contributed about 27% of the inactivation of GST P1-1 by 4-OEHN in vitro.	4-ohen gsh	13-23	glutathione S-transferase pi 1	Homo sapiens	80-86
12119004-6	2002	In addition, 4-OHEN GSH conjugates contributed about 27% of the inactivation of GST P1-1 by 4-OEHN in vitro.	4-oehn	92-98	glutathione S-transferase pi 1	Homo sapiens	80-86
12119004-9	2002	These data suggest that GST P1-1 may be a preferred protein target for equine catechol estrogens in vivo.	catechol	78-86	glutathione S-transferase pi 1	Homo sapiens	24-30
12072547-4	2002	In a retrospective study, we investigated associations between common polymorphisms in genes for several GST subclasses (GSTP1, GSTT1, GSTM1) and survival of patients with metastatic colorectal cancer receiving 5-fluorouracil (5-FU)/oxaliplatin chemotherapy.	Fluorouracil	211-225	glutathione S-transferase pi 1	Homo sapiens	121-126
11960994-4	2002	Treatment of Hep3B cells with 5-azadeoxycytidine (5-aza-dC), a methyltransferase inhibitor, activated GSTP1 expression, whereas treatment with trichostatin A, a histone deacetylase inhibitor, had little effect.	Decitabine	30-48	glutathione S-transferase pi 1	Homo sapiens	102-107
11960994-4	2002	Treatment of Hep3B cells with 5-azadeoxycytidine (5-aza-dC), a methyltransferase inhibitor, activated GSTP1 expression, whereas treatment with trichostatin A, a histone deacetylase inhibitor, had little effect.	Decitabine	50-58	glutathione S-transferase pi 1	Homo sapiens	102-107
11960994-4	2002	Treatment of Hep3B cells with 5-azadeoxycytidine (5-aza-dC), a methyltransferase inhibitor, activated GSTP1 expression, whereas treatment with trichostatin A, a histone deacetylase inhibitor, had little effect.	trichostatin A	143-157	glutathione S-transferase pi 1	Homo sapiens	102-107
11960994-6	2002	Bisulfite sequencing was used to map the methylation patterns of the GSTP1 promoter region in GSTP1-expressing and -non-expressing clones.	hydrogen sulfite	0-9	glutathione S-transferase pi 1	Homo sapiens	69-74
11960994-6	2002	Bisulfite sequencing was used to map the methylation patterns of the GSTP1 promoter region in GSTP1-expressing and -non-expressing clones.	hydrogen sulfite	0-9	glutathione S-transferase pi 1	Homo sapiens	94-99
12072547-13	2002	CONCLUSIONS: The GSTP1 Ile(105)Val polymorphism is associated in a dose-dependent fashion with increased survival of patients with advanced colorectal cancer receiving 5-FU/oxaliplatin chemotherapy.	Fluorouracil	168-172	glutathione S-transferase pi 1	Homo sapiens	17-22
12072547-13	2002	CONCLUSIONS: The GSTP1 Ile(105)Val polymorphism is associated in a dose-dependent fashion with increased survival of patients with advanced colorectal cancer receiving 5-FU/oxaliplatin chemotherapy.	Oxaliplatin	173-184	glutathione S-transferase pi 1	Homo sapiens	17-22
26680864-6	2002	When the data were stratified, by the known risk factors of breast cancer, a significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); women with GSTP1 Val allele, that drank regularly, had a 3.0-fold increased risk of breast cancer (95% CI=1.1~7.9), whereas women with GSTP1 Val allele, that never drink, had protective effects (OR=0.4, 95% CI=0.2~0.8).	Alcohols	145-152	glutathione S-transferase pi 1	Homo sapiens	126-131
11960994-9	2002	In contrast, Sp1 was detected at the GSTP1 promoter in a GSTP1-expressing Hep3B 5-aza-dC subclone.	5-aza-dc subclone	80-97	glutathione S-transferase pi 1	Homo sapiens	37-42
11960994-9	2002	In contrast, Sp1 was detected at the GSTP1 promoter in a GSTP1-expressing Hep3B 5-aza-dC subclone.	5-aza-dc subclone	80-97	glutathione S-transferase pi 1	Homo sapiens	57-62
26680864-6	2002	When the data were stratified, by the known risk factors of breast cancer, a significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); women with GSTP1 Val allele, that drank regularly, had a 3.0-fold increased risk of breast cancer (95% CI=1.1~7.9), whereas women with GSTP1 Val allele, that never drink, had protective effects (OR=0.4, 95% CI=0.2~0.8).	Alcohols	145-152	glutathione S-transferase pi 1	Homo sapiens	204-209
26680864-6	2002	When the data were stratified, by the known risk factors of breast cancer, a significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); women with GSTP1 Val allele, that drank regularly, had a 3.0-fold increased risk of breast cancer (95% CI=1.1~7.9), whereas women with GSTP1 Val allele, that never drink, had protective effects (OR=0.4, 95% CI=0.2~0.8).	Alcohols	145-152	glutathione S-transferase pi 1	Homo sapiens	204-209
26680864-7	2002	CONCLUSION: Our findings suggest that GSTP1 Ile105Val polymorphism influences the individual susceptibility to breast cancer, and that this effect may be modified by alcohol consumption.	Alcohols	166-173	glutathione S-transferase pi 1	Homo sapiens	38-43
11987150-6	2002	Re-expression of GSTP1 was determined by RT-PCR following treatment with 5-azacytidine, a DNA methyltransferase inhibitor, and/or the histone deacetylase inhibitor trichostatin A (TSA).	Azacitidine	73-86	glutathione S-transferase pi 1	Homo sapiens	17-22
12034316-1	2002	The aim of this study was to use DNA adducts levels, detected by 32P-postlabelling, as a biomarker to assess human exposure to polycyclic aromatic hydrocarbons (PAHs) from a coke oven plant and explore the possible association between CYP1A1 MspI, GSTP1, GSTM1 and GSTT1 genotypes, and smoking status on bulky DNA adduct formation.	Polycyclic Aromatic Hydrocarbons	161-165	glutathione S-transferase pi 1	Homo sapiens	248-253
11987150-6	2002	Re-expression of GSTP1 was determined by RT-PCR following treatment with 5-azacytidine, a DNA methyltransferase inhibitor, and/or the histone deacetylase inhibitor trichostatin A (TSA).	trichostatin A	164-178	glutathione S-transferase pi 1	Homo sapiens	17-22
11987150-6	2002	Re-expression of GSTP1 was determined by RT-PCR following treatment with 5-azacytidine, a DNA methyltransferase inhibitor, and/or the histone deacetylase inhibitor trichostatin A (TSA).	trichostatin A	180-183	glutathione S-transferase pi 1	Homo sapiens	17-22
11987150-9	2002	Treatment with the methyltransferase inhibitor 5-azacytidine resulted in re-expression of GSTP1.	Azacitidine	47-60	glutathione S-transferase pi 1	Homo sapiens	90-95
11994713-2	2002	OBJECTIVE: We sought to determine whether GSTP1 polymorphism influences susceptibility to asthma induced by toluene diisocyanate (TDI).	Toluene 2,4-Diisocyanate	108-128	glutathione S-transferase pi 1	Homo sapiens	42-47
11948486-6	2002	Diol epoxides are also substrates for phase II detoxifying enzymes, including GSTM and GSTP.	diol epoxides	0-13	glutathione S-transferase pi 1	Homo sapiens	87-91
11994713-2	2002	OBJECTIVE: We sought to determine whether GSTP1 polymorphism influences susceptibility to asthma induced by toluene diisocyanate (TDI).	Toluene 2,4-Diisocyanate	130-133	glutathione S-transferase pi 1	Homo sapiens	42-47
11994713-8	2002	CONCLUSION: These data suggest that homozygosity for the GSTP1*Val allele confers protection against TDI-induced asthma and airway hyperresponsiveness.	Toluene 2,4-Diisocyanate	101-104	glutathione S-transferase pi 1	Homo sapiens	57-62
12033460-5	2002	In the present study, the potency of several sulfur-containing compounds to protect acetylcholinesterase, glutathione S-transferase P1-1 (GST P1-1) and alpha1-antiproteinease against inactivation by HOCl was determined.	Sulfur	45-51	glutathione S-transferase pi 1	Homo sapiens	138-146
11948118-8	2002	Treatment of the cell lines with the DNA methyltransferase inhibitor 5-aza-deoxycytidine reversed the hypermethylation, and restored GSTP1 mRNA and polypeptide expression.	Decitabine	69-88	glutathione S-transferase pi 1	Homo sapiens	133-138
11927838-2	2002	Here, we extended the study to examine the possible role of N-acetyltransferase (NAT) genotypes in the development of diisocyanate-induced ill effects, both separately and in combination with the previously examined GSTM1, GSTM3, GSTP1 and GSTT1 genotypes.	4,4'-diphenylmethane diisocyanate	118-130	glutathione S-transferase pi 1	Homo sapiens	230-235
12033460-5	2002	In the present study, the potency of several sulfur-containing compounds to protect acetylcholinesterase, glutathione S-transferase P1-1 (GST P1-1) and alpha1-antiproteinease against inactivation by HOCl was determined.	Hypochlorous Acid	199-203	glutathione S-transferase pi 1	Homo sapiens	138-146
11849043-4	2002	Relative to control cells, those expressing GSTA1-1 showed the highest rate (about 50-fold increase) to perform GSH-conjugation of (-)-anti-DBPDE (R-absolute configuration at the benzylic oxirane carbon in the fjord-region) followed by GSTM1-1 (25-fold increase) and GSTP1-1 (10-fold increase).	Glutathione	112-115	glutathione S-transferase pi 1	Homo sapiens	267-274
11849043-9	2002	With (+)-anti-BPDE, GSTP1-1-expressing cells demonstrated a substantially higher rate of GSH-conjugate formation than cells with GSTA1-1 and GSTM1-1 cells (33- and 10-fold increase, respectively).	(+)-anti-bpde	5-18	glutathione S-transferase pi 1	Homo sapiens	20-27
11849043-9	2002	With (+)-anti-BPDE, GSTP1-1-expressing cells demonstrated a substantially higher rate of GSH-conjugate formation than cells with GSTA1-1 and GSTM1-1 cells (33- and 10-fold increase, respectively).	Glutathione	89-92	glutathione S-transferase pi 1	Homo sapiens	20-27
12112003-0	2002	Role of GST P1-1 in mediating the effect of etoposide on human neuroblastoma cell line Sh-Sy5y.	Etoposide	44-53	glutathione S-transferase pi 1	Homo sapiens	8-16
12210727-0	2002	Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation.	Cyclic AMP	0-10	glutathione S-transferase pi 1	Homo sapiens	20-25
12210727-0	2002	Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation.	Cyclic AMP	0-10	glutathione S-transferase pi 1	Homo sapiens	111-116
12210727-0	2002	Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation.	Cyclic AMP	0-10	glutathione S-transferase pi 1	Homo sapiens	111-116
12210727-4	2002	In this study, we report that the GSTP1 gene is an early cAMP response gene.	Cyclic AMP	57-61	glutathione S-transferase pi 1	Homo sapiens	34-39
12210727-6	2002	Western blot analysis showed a rapid, fivefold increase, in GSTP1 protein levels after treatment with 25 microM forskolin, with a peak at 2 h post-treatment.	Colforsin	112-121	glutathione S-transferase pi 1	Homo sapiens	60-65
12210727-11	2002	Finally, transfection studies using luciferase plasmid constructs showed the GSTP1 CRE to be required for the cAMP-activated gene expression.	Cyclic AMP	110-114	glutathione S-transferase pi 1	Homo sapiens	77-82
12210727-12	2002	Together, these findings describe a novel cAMP- and CREB-1-mediated mechanism of transcriptional regulation of the GSTP1 gene and suggest that this may be an important mechanism underlying the increased GSTP1 expression observed in tumors with an aberrant cAMP signaling pathway and in normal cells under conditions of stress, associated with increased intracellular cAMP.	Cyclic AMP	42-46	glutathione S-transferase pi 1	Homo sapiens	115-120
12210727-12	2002	Together, these findings describe a novel cAMP- and CREB-1-mediated mechanism of transcriptional regulation of the GSTP1 gene and suggest that this may be an important mechanism underlying the increased GSTP1 expression observed in tumors with an aberrant cAMP signaling pathway and in normal cells under conditions of stress, associated with increased intracellular cAMP.	Cyclic AMP	42-46	glutathione S-transferase pi 1	Homo sapiens	203-208
12210727-12	2002	Together, these findings describe a novel cAMP- and CREB-1-mediated mechanism of transcriptional regulation of the GSTP1 gene and suggest that this may be an important mechanism underlying the increased GSTP1 expression observed in tumors with an aberrant cAMP signaling pathway and in normal cells under conditions of stress, associated with increased intracellular cAMP.	Cyclic AMP	256-260	glutathione S-transferase pi 1	Homo sapiens	115-120
12210727-12	2002	Together, these findings describe a novel cAMP- and CREB-1-mediated mechanism of transcriptional regulation of the GSTP1 gene and suggest that this may be an important mechanism underlying the increased GSTP1 expression observed in tumors with an aberrant cAMP signaling pathway and in normal cells under conditions of stress, associated with increased intracellular cAMP.	Cyclic AMP	256-260	glutathione S-transferase pi 1	Homo sapiens	203-208
12210727-12	2002	Together, these findings describe a novel cAMP- and CREB-1-mediated mechanism of transcriptional regulation of the GSTP1 gene and suggest that this may be an important mechanism underlying the increased GSTP1 expression observed in tumors with an aberrant cAMP signaling pathway and in normal cells under conditions of stress, associated with increased intracellular cAMP.	Cyclic AMP	256-260	glutathione S-transferase pi 1	Homo sapiens	115-120
12210727-12	2002	Together, these findings describe a novel cAMP- and CREB-1-mediated mechanism of transcriptional regulation of the GSTP1 gene and suggest that this may be an important mechanism underlying the increased GSTP1 expression observed in tumors with an aberrant cAMP signaling pathway and in normal cells under conditions of stress, associated with increased intracellular cAMP.	Cyclic AMP	256-260	glutathione S-transferase pi 1	Homo sapiens	203-208
12112003-4	2002	Etoposide treatment was able to induce GST P1-1 polymerization and activation of apoptosis.	Etoposide	0-9	glutathione S-transferase pi 1	Homo sapiens	39-47
12112003-5	2002	The data obtained from our etoposide-resistant clone and the possibility to reverse the sensitive phenotype to a resistant one by means of hexyl-glutathione preincubation, seem to suggest that cellular levels of glutathione have a key role in protecting GST P1-1 by oxidation and consequently the cell"s decision between life and death.	Etoposide	27-36	glutathione S-transferase pi 1	Homo sapiens	254-262
12112003-5	2002	The data obtained from our etoposide-resistant clone and the possibility to reverse the sensitive phenotype to a resistant one by means of hexyl-glutathione preincubation, seem to suggest that cellular levels of glutathione have a key role in protecting GST P1-1 by oxidation and consequently the cell"s decision between life and death.	dipicrylamine	139-144	glutathione S-transferase pi 1	Homo sapiens	254-262
12112003-5	2002	The data obtained from our etoposide-resistant clone and the possibility to reverse the sensitive phenotype to a resistant one by means of hexyl-glutathione preincubation, seem to suggest that cellular levels of glutathione have a key role in protecting GST P1-1 by oxidation and consequently the cell"s decision between life and death.	Glutathione	212-223	glutathione S-transferase pi 1	Homo sapiens	254-262
11597790-7	2001	The polymorphic site within the exon 5 of GSTP1 results in a Ile-->Val substitution, and the isoleucine GSTpi isoform has been found in vitro to be less active than the valine isoform towards the conjugation of BPDE.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	42-47
11796315-1	2002	OBJECTIVES: Expression of glutathione S-transferase pi (GSTP1), a detoxification enzyme that also binds steroid hormones, is diminished or absent in human prostate tumors possibly because of promoter hypermethylation.	Steroids	104-120	glutathione S-transferase pi 1	Homo sapiens	56-61
11751372-0	2001	Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide.	Procainamide	169-181	glutathione S-transferase pi 1	Homo sapiens	12-17
11751372-0	2001	Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide.	Procainamide	169-181	glutathione S-transferase pi 1	Homo sapiens	102-107
11751372-9	2001	We report here that the drug procainamide, a nonnucleoside inhibitor of DNA methyltransferases, reversed GSTP1 CpG island hypermethylation and restored GSTP1 expression in LNCaP human PCA cells propagated in vitro or in vivo as xenograft tumors in athymic nude mice.	Procainamide	29-41	glutathione S-transferase pi 1	Homo sapiens	105-110
11751372-9	2001	We report here that the drug procainamide, a nonnucleoside inhibitor of DNA methyltransferases, reversed GSTP1 CpG island hypermethylation and restored GSTP1 expression in LNCaP human PCA cells propagated in vitro or in vivo as xenograft tumors in athymic nude mice.	Procainamide	29-41	glutathione S-transferase pi 1	Homo sapiens	152-157
11597790-7	2001	The polymorphic site within the exon 5 of GSTP1 results in a Ile-->Val substitution, and the isoleucine GSTpi isoform has been found in vitro to be less active than the valine isoform towards the conjugation of BPDE.	Valine	172-178	glutathione S-transferase pi 1	Homo sapiens	42-47
11597790-7	2001	The polymorphic site within the exon 5 of GSTP1 results in a Ile-->Val substitution, and the isoleucine GSTpi isoform has been found in vitro to be less active than the valine isoform towards the conjugation of BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	214-218	glutathione S-transferase pi 1	Homo sapiens	42-47
11640916-0	2001	Hypochlorous acid is a potent inhibitor of GST P1-1.	Hypochlorous Acid	0-17	glutathione S-transferase pi 1	Homo sapiens	43-51
11533048-4	2001	Ion spray ionization-mass spectrometry ruled out the possibility of S-glutathionylation and confirms the occurrence of a poly-S-nitrosylation in GST P1-1.	poly-s	121-127	glutathione S-transferase pi 1	Homo sapiens	145-153
11696442-7	2001	GSTP1 CpG island DNA hypermethylation was responsible for lack of GSTP1 expression by LNCaP PCA cells: treatment of the cells with 5-azacytidine (5-aza-C), an inhibitor of DNA methyltransferases, reversed the GSTP1 promoter DNA hypermethylation, activated GSTP1 transcription, and restored GSTP1 expression.	Azacitidine	131-144	glutathione S-transferase pi 1	Homo sapiens	0-5
11696442-7	2001	GSTP1 CpG island DNA hypermethylation was responsible for lack of GSTP1 expression by LNCaP PCA cells: treatment of the cells with 5-azacytidine (5-aza-C), an inhibitor of DNA methyltransferases, reversed the GSTP1 promoter DNA hypermethylation, activated GSTP1 transcription, and restored GSTP1 expression.	Azacitidine	146-153	glutathione S-transferase pi 1	Homo sapiens	0-5
11696442-8	2001	GSTP1 promoter activity, assessed via transfection of GSTP1 promoter-CAT reporter constructs in LNCaP cells, was inhibited by SssI-catalyzed CpG dinucleotide methylation.	cytidylyl-3'-5'-guanosine	141-157	glutathione S-transferase pi 1	Homo sapiens	0-5
11696442-8	2001	GSTP1 promoter activity, assessed via transfection of GSTP1 promoter-CAT reporter constructs in LNCaP cells, was inhibited by SssI-catalyzed CpG dinucleotide methylation.	cytidylyl-3'-5'-guanosine	141-157	glutathione S-transferase pi 1	Homo sapiens	54-59
11600727-10	2001	There was less association between the concentrations of 1-OHP and the GSTM1, GSTP1, or GSTT1 polymorphism.	Oxaliplatin	57-62	glutathione S-transferase pi 1	Homo sapiens	78-83
11717336-3	2001	METHODS: We used a fluorogenic real-time methylation-specific polymerase chain reaction (MSP) assay to analyze cytidine methylation in the GSTP1 promoter in prostate tissue samples from 69 patients with early-stage prostatic adenocarcinoma (28 of whom also had prostatic intraepithelial neoplasia lesions) and 31 patients with benign prostatic hyperplasia.	Cytidine	111-119	glutathione S-transferase pi 1	Homo sapiens	139-144
11640916-4	2001	We studied the influence of HOCl on the activity of GST P1-1.	Hypochlorous Acid	28-32	glutathione S-transferase pi 1	Homo sapiens	52-60
11640916-7	2001	Our results show that HOCl is a potent, non-competitive inhibitor of GST P1-1.	Hypochlorous Acid	22-26	glutathione S-transferase pi 1	Homo sapiens	69-77
11606500-1	2001	BACKGROUND & AIMS: In colorectal adenoma and carcinoma, glutathione S-transferase-pi (GSTP1-1) is highly expressed.	Adenosine Monophosphate	12-15	glutathione S-transferase pi 1	Homo sapiens	90-97
11757669-0	2001	Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population.	Glutathione	17-28	glutathione S-transferase pi 1	Homo sapiens	57-62
11553769-9	2001	These data suggest that inheritance of at least one Val allele at GSTP1 codon 105 confers a significantly increased risk of developing t-AML after cytotoxic chemotherapy, but not after radiotherapy.	Valine	52-55	glutathione S-transferase pi 1	Homo sapiens	66-71
11535247-6	2001	The data, therefore, point to a possible influence of a human enzyme polymorphism of the GSTP1 gene at codon 104 on the detoxication of acrylonitrile which calls for experimental toxicological investigation.	Acrylonitrile	136-149	glutathione S-transferase pi 1	Homo sapiens	89-94
11535248-6	2001	Using multifactorial statistical analysis we found significant associations between smoking, GSTP1 genotype, plasma Vitamin C, and purine base damage in lymphocyte DNA.	purine	131-137	glutathione S-transferase pi 1	Homo sapiens	93-98
11535248-7	2001	The difference in Vitamin C plasma levels between smokers and non-smokers was seen only with the GSTP1 b/b genotype.	Ascorbic Acid	18-27	glutathione S-transferase pi 1	Homo sapiens	97-102
11535249-6	2001	Our results suggest interactions between GSTM1 and GSTP1 alleles in modulation of urinary 1-OHPY levels and white blood cell DNA adduct levels in the PAH-exposed workers.	1-ohpy	90-96	glutathione S-transferase pi 1	Homo sapiens	51-56
11535249-6	2001	Our results suggest interactions between GSTM1 and GSTP1 alleles in modulation of urinary 1-OHPY levels and white blood cell DNA adduct levels in the PAH-exposed workers.	p-Aminohippuric Acid	150-153	glutathione S-transferase pi 1	Homo sapiens	51-56
11351295-8	2001	Stable transfection of HEp2 cells with human GSTP1 increases doxorubicin resistance 3-fold over control cells.	Doxorubicin	61-72	glutathione S-transferase pi 1	Homo sapiens	45-50
11601682-5	2001	In fact, several antineoplastic drugs used in the neuroblastoma high-risk chemotherapeutic protocol are potential substrates of GSTP1-1 (etoposide, adriamycin and carboplatin).	Etoposide	137-146	glutathione S-transferase pi 1	Homo sapiens	128-135
11601682-5	2001	In fact, several antineoplastic drugs used in the neuroblastoma high-risk chemotherapeutic protocol are potential substrates of GSTP1-1 (etoposide, adriamycin and carboplatin).	Doxorubicin	148-158	glutathione S-transferase pi 1	Homo sapiens	128-135
11601682-5	2001	In fact, several antineoplastic drugs used in the neuroblastoma high-risk chemotherapeutic protocol are potential substrates of GSTP1-1 (etoposide, adriamycin and carboplatin).	Carboplatin	163-174	glutathione S-transferase pi 1	Homo sapiens	128-135
11451434-1	2001	alpha-Tocopherol inhibits glutathione S-transferase P1-1 (GST P1-1) (R.I.M.	alpha-Tocopherol	0-16	glutathione S-transferase pi 1	Homo sapiens	58-66
11451434-10	2001	Therefore we have studied the effect of various tocopherol derivatives on GST P1-1 activity.	Tocopherols	48-58	glutathione S-transferase pi 1	Homo sapiens	74-82
11451434-15	2001	This indicates that the GST P1-1 enzyme is non-competitively inhibited by RRR-alpha-tocopherol acetate.	alpha-Tocopherol	78-102	glutathione S-transferase pi 1	Homo sapiens	24-32
11451434-16	2001	The potential implications of GST P1-1 inhibition by tocopherol and alpha-tocopherol derivatives are discussed.	Tocopherols	53-63	glutathione S-transferase pi 1	Homo sapiens	30-38
11451434-16	2001	The potential implications of GST P1-1 inhibition by tocopherol and alpha-tocopherol derivatives are discussed.	alpha-Tocopherol	68-84	glutathione S-transferase pi 1	Homo sapiens	30-38
11433346-3	2001	Here we show that glutathione S-transferase P1-1 (GSTP1) interacts with FANCC, and that overexpression of both proteins in a myeloid progenitor cell line prevents apoptosis following factor deprivation.	Glutathione	18-29	glutathione S-transferase pi 1	Homo sapiens	50-55
11433346-6	2001	Although FANCC lacks homology with conventional disulfide reductases, it functions by preventing the formation of inactivating disulfide bonds within GSTP1 during apoptosis.	Disulfides	48-57	glutathione S-transferase pi 1	Homo sapiens	150-155
11466305-6	2001	In permeabilized Jurkat T cells, GST-p59(fyn), but not GST-p56(lck), GST-Grb2, or GST alone, significantly and concentration-dependently enhanced Ca(2+) release by cyclic ADP-ribose.	Cyclic ADP-Ribose	164-181	glutathione S-transferase pi 1	Homo sapiens	33-38
11549474-3	2001	METHODS: Bisulfite treatment followed by methylation-specific polymerase chain reaction was used to detect GSTP1 promoter hypermethylation in DNA isolated from urine sediments obtained after prostatic massage of men with and without prostate cancer.	hydrogen sulfite	9-18	glutathione S-transferase pi 1	Homo sapiens	107-112
11351295-0	2001	Role of glutathione S-transferase P1, P-glycoprotein and multidrug resistance-associated protein 1 in acquired doxorubicin resistance.	Doxorubicin	111-122	glutathione S-transferase pi 1	Homo sapiens	8-36
11351295-9	2001	Our study indicates involvement of GSTP enzymes as well as efflux mechanisms in the acquired doxorubicin-resistance phenotype.	Doxorubicin	93-104	glutathione S-transferase pi 1	Homo sapiens	35-39
11434510-6	2001	The GSTP1 gene has a polymorphism at codon 105 resulting in an Ile to Val substitution which consequently alters the enzymatic activity of the protein and this has been suggested as a putative high-risk genotype in various cancers.	Isoleucine	63-66	glutathione S-transferase pi 1	Homo sapiens	4-9
11406558-5	2001	In a transient transfection assay using LNCaP cells, methylation of the GSTP1 promoter-driven luciferase reporter vector (GSTP1-pGL3) resulted in a >20-fold inhibition of transcription, and this repression was not relieved by the presence of a histone deacetylase inhibitor, trichostatin A (TSA).	trichostatin A	278-292	glutathione S-transferase pi 1	Homo sapiens	72-77
11406558-5	2001	In a transient transfection assay using LNCaP cells, methylation of the GSTP1 promoter-driven luciferase reporter vector (GSTP1-pGL3) resulted in a >20-fold inhibition of transcription, and this repression was not relieved by the presence of a histone deacetylase inhibitor, trichostatin A (TSA).	trichostatin A	278-292	glutathione S-transferase pi 1	Homo sapiens	122-127
11406558-5	2001	In a transient transfection assay using LNCaP cells, methylation of the GSTP1 promoter-driven luciferase reporter vector (GSTP1-pGL3) resulted in a >20-fold inhibition of transcription, and this repression was not relieved by the presence of a histone deacetylase inhibitor, trichostatin A (TSA).	trichostatin A	294-297	glutathione S-transferase pi 1	Homo sapiens	72-77
11406558-5	2001	In a transient transfection assay using LNCaP cells, methylation of the GSTP1 promoter-driven luciferase reporter vector (GSTP1-pGL3) resulted in a >20-fold inhibition of transcription, and this repression was not relieved by the presence of a histone deacetylase inhibitor, trichostatin A (TSA).	trichostatin A	294-297	glutathione S-transferase pi 1	Homo sapiens	122-127
11406558-6	2001	Treatment of LNCaP cells with a DNA methyltransferase inhibitor, 5-Aza-2"-deoxycytidine, resulted in demethylation and activation of the GSTP1 gene.	Decitabine	65-87	glutathione S-transferase pi 1	Homo sapiens	137-142
11406558-9	2001	These data demonstrate that cytosine methylation can repress GSTP1 gene expression in LNCaP prostate cancer cells and that this effect is possibly mediated by a methyl cytosine-binding protein complex 1-like complex.	Cytosine	28-36	glutathione S-transferase pi 1	Homo sapiens	61-66
11434510-6	2001	The GSTP1 gene has a polymorphism at codon 105 resulting in an Ile to Val substitution which consequently alters the enzymatic activity of the protein and this has been suggested as a putative high-risk genotype in various cancers.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	4-9
11307147-5	2001	Both polymorphic GSTP1 alleles have an A-to-G transition in exon 5, causing an isoleucine-to-valine change.	Isoleucine	79-89	glutathione S-transferase pi 1	Homo sapiens	17-22
11307147-5	2001	Both polymorphic GSTP1 alleles have an A-to-G transition in exon 5, causing an isoleucine-to-valine change.	Valine	93-99	glutathione S-transferase pi 1	Homo sapiens	17-22
11874074-8	2001	In the subgroup of patients that received cisplatin-based chemotherapy (n = 14) significantly higher GSTP1-1 (p = 0.01) concentrations were found in patients with recurrence compared with patients without recurrence.	Cisplatin	42-51	glutathione S-transferase pi 1	Homo sapiens	101-108
11368548-6	2001	The kinetic data show that 2-phenylpropenal is a substrate for all three isoforms tested, with a k(cat)/K(m) of 0.275 +/- 0.035 microM(-1) s(-1) for GSTM1-1, 0.164 +/- 0.005 microM(-1) s(-1) for GSTP1-1, and 0.042 +/- 0.005 microM(-1) s(-1) for GSTA1-1.	hydratropic aldehyde	27-43	glutathione S-transferase pi 1	Homo sapiens	195-202
11368548-7	2001	Given that electrophilic substrates such as 2-propenal have been shown to inhibit GSTs, we also examined the inhibition of GSTM1-1, GSTP1-1 and GSTA1-1 by 2-phenylpropenal.	hydratropic aldehyde	155-171	glutathione S-transferase pi 1	Homo sapiens	132-139
11368548-8	2001	The enzyme inhibition studies demonstrate that 2-phenylpropenal inhibits GSTP1-1 and GSTM1-1.	hydratropic aldehyde	47-63	glutathione S-transferase pi 1	Homo sapiens	73-80
11368548-9	2001	The inhibition of GSTP1-1 was completely reversible upon filtration and reconstitution in buffer containing 10 mM GSH.	Glutathione	114-117	glutathione S-transferase pi 1	Homo sapiens	18-25
11295612-8	2001	GSTP1 is an enzyme that helps catalyze the conjugation reaction between potentially damaging electrophiles and glutathione.	Glutathione	111-122	glutathione S-transferase pi 1	Homo sapiens	0-5
11226521-0	2001	Phorbol ester responsiveness of the glutathione S-transferase P1 gene promoter involves an inducible c-jun binding in human K562 leukemia cells.	Phorbol Esters	0-13	glutathione S-transferase pi 1	Homo sapiens	36-64
11226521-4	2001	Promoter deletion analyses revealed that the activator protein-1 (AP-1) transcription factor site was crucial for 12-O-tetradecanoyl phorbol 13-acetate (TPA)-mediated GSTP1 gene transcription.	Tetradecanoylphorbol Acetate	114-151	glutathione S-transferase pi 1	Homo sapiens	167-172
11226521-4	2001	Promoter deletion analyses revealed that the activator protein-1 (AP-1) transcription factor site was crucial for 12-O-tetradecanoyl phorbol 13-acetate (TPA)-mediated GSTP1 gene transcription.	Tetradecanoylphorbol Acetate	153-156	glutathione S-transferase pi 1	Homo sapiens	167-172
11226521-7	2001	These results show for the first time that the phorbol ester TPA is involved in the molecular mechanism(s) mediating the activation of the GSTP1 promoter in a human leukemia model.	Phorbol Esters	47-60	glutathione S-transferase pi 1	Homo sapiens	139-144
11226521-7	2001	These results show for the first time that the phorbol ester TPA is involved in the molecular mechanism(s) mediating the activation of the GSTP1 promoter in a human leukemia model.	Tetradecanoylphorbol Acetate	61-64	glutathione S-transferase pi 1	Homo sapiens	139-144
12718659-2	2001	However, the species of glutathione S-transferases (GSTP1-1) linked to neoplasia of rat and human were recently shown to be selective for hydrophilic carcinogens such as acrolein and hydroxyalkenals (Satoh, 1998; Satoh et al., 1999) in accord with the finding of a water-network in the active site of the human GSTP1-1 by X-ray analysis (Hu et al.	hydroxyalkenals	183-198	glutathione S-transferase pi 1	Homo sapiens	311-318
12718659-2	2001	However, the species of glutathione S-transferases (GSTP1-1) linked to neoplasia of rat and human were recently shown to be selective for hydrophilic carcinogens such as acrolein and hydroxyalkenals (Satoh, 1998; Satoh et al., 1999) in accord with the finding of a water-network in the active site of the human GSTP1-1 by X-ray analysis (Hu et al.	Water	265-270	glutathione S-transferase pi 1	Homo sapiens	311-318
23889309-0	2001	Benzo(a)pyrene diolepoxide adducts to albumin in workers exposed to polycyclic aromatic hydrocarbons: association with specific CYP1A1, GSTM1, GSTP1 and EHPX genotypes.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-26	glutathione S-transferase pi 1	Homo sapiens	143-148
11196146-0	2001	Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1.	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	19-73	glutathione S-transferase pi 1	Homo sapiens	133-161
11196146-7	2001	Both LNCaP and LNCaP-GSTP1 cells exposed to N-OH-PhIP, but not parent PhIP, for 24 h showed a dose-dependent decrease in cell viability.	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	44-53	glutathione S-transferase pi 1	Homo sapiens	21-26
11196146-11	2001	Bioactivation assays using LNCaP cytosols showed that enzymatic activation of N-OH-PhIP to a DNA binding species was dependent on ATP and could be inhibited by recombinant human GSTP1 in the presence of glutathione.	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	78-87	glutathione S-transferase pi 1	Homo sapiens	178-183
11196146-11	2001	Bioactivation assays using LNCaP cytosols showed that enzymatic activation of N-OH-PhIP to a DNA binding species was dependent on ATP and could be inhibited by recombinant human GSTP1 in the presence of glutathione.	Adenosine Triphosphate	130-133	glutathione S-transferase pi 1	Homo sapiens	178-183
11196146-11	2001	Bioactivation assays using LNCaP cytosols showed that enzymatic activation of N-OH-PhIP to a DNA binding species was dependent on ATP and could be inhibited by recombinant human GSTP1 in the presence of glutathione.	Glutathione	203-214	glutathione S-transferase pi 1	Homo sapiens	178-183
11196146-14	2001	Loss of GSTP1 expression in human prostate may, therefore, enhance its susceptibility to carcinogenic insult by compounds such as N-OH-PhIP.	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	130-139	glutathione S-transferase pi 1	Homo sapiens	8-13
11294649-9	2001	These results demonstrate that hGST P1-1 is inactivated by 4-OHEN through two possible mechanisms: (1) covalent modification of cysteine residues and (2) oxidative damage leading to proteins inactivated by disulfide bond formation.	4-ohen	59-65	glutathione S-transferase pi 1	Homo sapiens	31-40
11294649-9	2001	These results demonstrate that hGST P1-1 is inactivated by 4-OHEN through two possible mechanisms: (1) covalent modification of cysteine residues and (2) oxidative damage leading to proteins inactivated by disulfide bond formation.	Cysteine	128-136	glutathione S-transferase pi 1	Homo sapiens	31-40
11294649-9	2001	These results demonstrate that hGST P1-1 is inactivated by 4-OHEN through two possible mechanisms: (1) covalent modification of cysteine residues and (2) oxidative damage leading to proteins inactivated by disulfide bond formation.	Disulfides	206-215	glutathione S-transferase pi 1	Homo sapiens	31-40
12718659-2	2001	However, the species of glutathione S-transferases (GSTP1-1) linked to neoplasia of rat and human were recently shown to be selective for hydrophilic carcinogens such as acrolein and hydroxyalkenals (Satoh, 1998; Satoh et al., 1999) in accord with the finding of a water-network in the active site of the human GSTP1-1 by X-ray analysis (Hu et al.	Acrolein	170-178	glutathione S-transferase pi 1	Homo sapiens	311-318
23889309-6	2001	Exposed workers with GSTM1 null/GSTP1 variant alleles had fewer detectable adducts than those with the GSTM1 null/GSTP1*A wild-type allele, supporting for the first time the recent in vitro finding that GSTP1 variants may be more effective in the detoxification of BPDE than the wild-type allele.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	265-269	glutathione S-transferase pi 1	Homo sapiens	32-37
11159743-1	2001	The phase II glutathione S-transferases (GSTs) GSTT1, GSTM1 and GSTP1 catalyse glutathione-mediated reduction of exogenous and endogenous electrophiles.	Glutathione	13-24	glutathione S-transferase pi 1	Homo sapiens	64-69
12094619-6	2001	Our results show that GSTP1 mRNA, GSTP1 protein, GST activity, and total protein were increased (1.2- to 2.5-fold) and glutathione levels were maintained after 24-72 h of incubation with 4 mM butyrate.	Butyrates	192-200	glutathione S-transferase pi 1	Homo sapiens	22-27
11108808-10	2000	Indeed, their synthetic C(7)-aglycon-GSH conjugates exerted a strong inhibitory effect on GST P1-1, with K(i) at 25 degrees in the 1-2 microM range, scarcely dependent on their stereochemistry at C(7).	Glutathione	37-40	glutathione S-transferase pi 1	Homo sapiens	90-98
11108808-4	2000	Adriamycin-resistant human breast cancer MCF-7/DOX cells, presenting a comparable GSH concentration, but a 14-fold increase of the GST P1-1 activity relative to the sensitive MCF-7 cells, have been treated with adriamycin in the presence of verapamil, an inhibitor of the 170 P-glycoprotein (P-gp) drug transport protein, and scrutinized for any production of GSH-adriamycin conjugates.	Doxorubicin	0-10	glutathione S-transferase pi 1	Homo sapiens	131-137
11113459-2	2000	The Pi class human glutathione (GSH) transferase (hGSTP1-1), which is polymorphic in humans with respect to amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), plays an important role in the detoxification of PAH-diol epoxides.	Glutathione	19-30	glutathione S-transferase pi 1	Homo sapiens	50-58
11108808-4	2000	Adriamycin-resistant human breast cancer MCF-7/DOX cells, presenting a comparable GSH concentration, but a 14-fold increase of the GST P1-1 activity relative to the sensitive MCF-7 cells, have been treated with adriamycin in the presence of verapamil, an inhibitor of the 170 P-glycoprotein (P-gp) drug transport protein, and scrutinized for any production of GSH-adriamycin conjugates.	Doxorubicin	211-221	glutathione S-transferase pi 1	Homo sapiens	131-137
11113459-6	2000	The results of the present study clearly indicate that the location of the epoxide function determines specificity of the allelic variants of hGSTP1-1 in the GSH conjugation of activated diol epoxide isomers of B[c]C.	Epoxy Compounds	75-82	glutathione S-transferase pi 1	Homo sapiens	142-150
11113459-6	2000	The results of the present study clearly indicate that the location of the epoxide function determines specificity of the allelic variants of hGSTP1-1 in the GSH conjugation of activated diol epoxide isomers of B[c]C.	Glutathione	158-161	glutathione S-transferase pi 1	Homo sapiens	142-150
11113459-6	2000	The results of the present study clearly indicate that the location of the epoxide function determines specificity of the allelic variants of hGSTP1-1 in the GSH conjugation of activated diol epoxide isomers of B[c]C.	diol epoxide	187-199	glutathione S-transferase pi 1	Homo sapiens	142-150
11113459-2	2000	The Pi class human glutathione (GSH) transferase (hGSTP1-1), which is polymorphic in humans with respect to amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), plays an important role in the detoxification of PAH-diol epoxides.	Glutathione	32-35	glutathione S-transferase pi 1	Homo sapiens	50-58
11113459-2	2000	The Pi class human glutathione (GSH) transferase (hGSTP1-1), which is polymorphic in humans with respect to amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), plays an important role in the detoxification of PAH-diol epoxides.	Isoleucine	146-156	glutathione S-transferase pi 1	Homo sapiens	50-58
11113459-2	2000	The Pi class human glutathione (GSH) transferase (hGSTP1-1), which is polymorphic in humans with respect to amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), plays an important role in the detoxification of PAH-diol epoxides.	Valine	160-166	glutathione S-transferase pi 1	Homo sapiens	50-58
11113459-2	2000	The Pi class human glutathione (GSH) transferase (hGSTP1-1), which is polymorphic in humans with respect to amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), plays an important role in the detoxification of PAH-diol epoxides.	Alanine	180-187	glutathione S-transferase pi 1	Homo sapiens	50-58
11113459-2	2000	The Pi class human glutathione (GSH) transferase (hGSTP1-1), which is polymorphic in humans with respect to amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), plays an important role in the detoxification of PAH-diol epoxides.	Valine	191-197	glutathione S-transferase pi 1	Homo sapiens	50-58
11113459-2	2000	The Pi class human glutathione (GSH) transferase (hGSTP1-1), which is polymorphic in humans with respect to amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), plays an important role in the detoxification of PAH-diol epoxides.	pah-diol epoxides	249-266	glutathione S-transferase pi 1	Homo sapiens	50-58
11113459-3	2000	Here, we report that the location of the epoxide function determines specificity of allelic variants of hGSTP1-1 toward racemic anti-diol epoxide isomers of benzo[c]chrysene (B[c]C).	Epoxy Compounds	41-48	glutathione S-transferase pi 1	Homo sapiens	104-110
11113459-3	2000	Here, we report that the location of the epoxide function determines specificity of allelic variants of hGSTP1-1 toward racemic anti-diol epoxide isomers of benzo[c]chrysene (B[c]C).	diol epoxide	133-145	glutathione S-transferase pi 1	Homo sapiens	104-110
11113459-3	2000	Here, we report that the location of the epoxide function determines specificity of allelic variants of hGSTP1-1 toward racemic anti-diol epoxide isomers of benzo[c]chrysene (B[c]C).	chrysene	165-173	glutathione S-transferase pi 1	Homo sapiens	104-110
11113459-4	2000	The catalytic efficiency (k(cat)/K(m)) of V104,A113 (VA) and V104,V113 (VV) variants of hGSTP1-1 was approximately 2.3- and 1.7-fold higher, respectively, than that of the I104,A113 (IA) isoform toward bay region isomer (+/-)-anti-B[c]C-1,2-diol-3,4-epoxide.	Carbon	235-236	glutathione S-transferase pi 1	Homo sapiens	88-96
11113459-4	2000	The catalytic efficiency (k(cat)/K(m)) of V104,A113 (VA) and V104,V113 (VV) variants of hGSTP1-1 was approximately 2.3- and 1.7-fold higher, respectively, than that of the I104,A113 (IA) isoform toward bay region isomer (+/-)-anti-B[c]C-1,2-diol-3,4-epoxide.	1,2-diol-3,4-epoxide	237-257	glutathione S-transferase pi 1	Homo sapiens	88-96
11071881-4	2000	Here, we report that the allelic variants of hGSTP1-1 significantly differ in their efficiency in catalyzing the GSH conjugation of chlorambucil.	Chlorambucil	132-144	glutathione S-transferase pi 1	Homo sapiens	45-51
11071881-2	2000	Increased glutathione (GSH) conjugation (inactivation) of alkylating anticancer drugs or their activated metabolites due to overexpression of the Pi class GSH S-transferase (hGSTP1-1) is believed to be an important mechanism in tumor cell resistance to alkylating agents.	Glutathione	10-21	glutathione S-transferase pi 1	Homo sapiens	174-182
11071881-5	2000	Catalytic efficiency of the hGSTP1-1(I104,A113) isoform toward chlorambucil was approximately 2.5-, 7.5- and 15-fold higher compared with I104,V113, V104,A113 and V104,V113 variants of hGSTP1-1, respectively.	Chlorambucil	63-75	glutathione S-transferase pi 1	Homo sapiens	28-34
11071881-2	2000	Increased glutathione (GSH) conjugation (inactivation) of alkylating anticancer drugs or their activated metabolites due to overexpression of the Pi class GSH S-transferase (hGSTP1-1) is believed to be an important mechanism in tumor cell resistance to alkylating agents.	Glutathione	23-26	glutathione S-transferase pi 1	Homo sapiens	174-182
11071881-5	2000	Catalytic efficiency of the hGSTP1-1(I104,A113) isoform toward chlorambucil was approximately 2.5-, 7.5- and 15-fold higher compared with I104,V113, V104,A113 and V104,V113 variants of hGSTP1-1, respectively.	Chlorambucil	63-75	glutathione S-transferase pi 1	Homo sapiens	28-36
11071881-3	2000	Interestingly, the hGSTP1 locus is polymorphic in human populations and involves amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine).	Isoleucine	119-129	glutathione S-transferase pi 1	Homo sapiens	19-25
11108662-3	2000	Expression of GSTP1-1 was associated with a fourfold to tenfold protection from 4NQO-induced cytotoxicity.	4-Nitroquinoline-1-oxide	80-84	glutathione S-transferase pi 1	Homo sapiens	14-21
11071881-3	2000	Interestingly, the hGSTP1 locus is polymorphic in human populations and involves amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine).	Valine	133-139	glutathione S-transferase pi 1	Homo sapiens	19-25
11071881-3	2000	Interestingly, the hGSTP1 locus is polymorphic in human populations and involves amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine).	Alanine	153-160	glutathione S-transferase pi 1	Homo sapiens	19-25
11071881-3	2000	Interestingly, the hGSTP1 locus is polymorphic in human populations and involves amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine).	Valine	164-170	glutathione S-transferase pi 1	Homo sapiens	19-25
11071881-4	2000	Here, we report that the allelic variants of hGSTP1-1 significantly differ in their efficiency in catalyzing the GSH conjugation of chlorambucil.	Glutathione	113-116	glutathione S-transferase pi 1	Homo sapiens	45-51
11108662-4	2000	Inhibition of MRP2-mediated efflux activity by sulfinpyrazone or cyclosporin A completely reversed GSTP1-1-associated resistance-a result indicating that GSTP1-1-mediated cytoprotection is absolutely dependent on MRP2 efflux activity.	Sulfinpyrazone	47-61	glutathione S-transferase pi 1	Homo sapiens	99-106
11108662-4	2000	Inhibition of MRP2-mediated efflux activity by sulfinpyrazone or cyclosporin A completely reversed GSTP1-1-associated resistance-a result indicating that GSTP1-1-mediated cytoprotection is absolutely dependent on MRP2 efflux activity.	Sulfinpyrazone	47-61	glutathione S-transferase pi 1	Homo sapiens	154-161
11108662-4	2000	Inhibition of MRP2-mediated efflux activity by sulfinpyrazone or cyclosporin A completely reversed GSTP1-1-associated resistance-a result indicating that GSTP1-1-mediated cytoprotection is absolutely dependent on MRP2 efflux activity.	Cyclosporine	65-78	glutathione S-transferase pi 1	Homo sapiens	99-106
11108662-4	2000	Inhibition of MRP2-mediated efflux activity by sulfinpyrazone or cyclosporin A completely reversed GSTP1-1-associated resistance-a result indicating that GSTP1-1-mediated cytoprotection is absolutely dependent on MRP2 efflux activity.	Cyclosporine	65-78	glutathione S-transferase pi 1	Homo sapiens	154-161
11108662-5	2000	Moreover, MRP2 efflux activity also augmented GSTP1-1-mediated protection from 4NQO-induced nucleic-acid adduct formation.	4-Nitroquinoline-1-oxide	79-83	glutathione S-transferase pi 1	Homo sapiens	46-53
11108662-6	2000	We conclude that MRP2-mediated efflux of the glutathione conjugate of 4NQO and/or another toxic derivative of 4NQO is required to support GSTP1-1-associated protection from 4NQO toxicities in HepG2 cells.	Glutathione	45-56	glutathione S-transferase pi 1	Homo sapiens	138-145
11108662-6	2000	We conclude that MRP2-mediated efflux of the glutathione conjugate of 4NQO and/or another toxic derivative of 4NQO is required to support GSTP1-1-associated protection from 4NQO toxicities in HepG2 cells.	4-Nitroquinoline-1-oxide	70-74	glutathione S-transferase pi 1	Homo sapiens	138-145
11108662-6	2000	We conclude that MRP2-mediated efflux of the glutathione conjugate of 4NQO and/or another toxic derivative of 4NQO is required to support GSTP1-1-associated protection from 4NQO toxicities in HepG2 cells.	4-Nitroquinoline-1-oxide	110-114	glutathione S-transferase pi 1	Homo sapiens	138-145
11059750-1	2000	A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents.	ile105val	89-98	glutathione S-transferase pi 1	Homo sapiens	2-36
11059750-1	2000	A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents.	Valine	95-98	glutathione S-transferase pi 1	Homo sapiens	2-36
10996298-5	2000	The presence of GSTP1-1 significantly accelerated the initial rate of GSH-mediated consumption of curcumin in 10 mM potassium phosphate, pH 7.0, and 1 mM GSH.	Curcumin	98-106	glutathione S-transferase pi 1	Homo sapiens	16-23
11027134-17	2000	The lack of mobility of helix alpha9 and/or the lack of electrostatic assistance from R216 may be responsible for the relatively lower activity of hGSTA1-1, mGSTA4-4, and hGSTP1-1 toward (+)-anti-BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	196-200	glutathione S-transferase pi 1	Homo sapiens	171-179
11008209-6	2000	Among alcohol drinkers, borderline significance was also found for GSTP1 Ile/Ile genotype (OR 2.0, 95% CI 0.9-4.4).	Alcohols	6-13	glutathione S-transferase pi 1	Homo sapiens	67-72
10970734-4	2000	In the present work, variants of human GSTP1-1 (S150A and D153A), in which the capping residues have been substituted by alanine, have been generated and purified for structural analysis.	Alanine	121-128	glutathione S-transferase pi 1	Homo sapiens	39-46
10996298-5	2000	The presence of GSTP1-1 significantly accelerated the initial rate of GSH-mediated consumption of curcumin in 10 mM potassium phosphate, pH 7.0, and 1 mM GSH.	Glutathione	70-73	glutathione S-transferase pi 1	Homo sapiens	16-23
10996298-5	2000	The presence of GSTP1-1 significantly accelerated the initial rate of GSH-mediated consumption of curcumin in 10 mM potassium phosphate, pH 7.0, and 1 mM GSH.	potassium phosphate	116-135	glutathione S-transferase pi 1	Homo sapiens	16-23
10996298-5	2000	The presence of GSTP1-1 significantly accelerated the initial rate of GSH-mediated consumption of curcumin in 10 mM potassium phosphate, pH 7.0, and 1 mM GSH.	Glutathione	154-157	glutathione S-transferase pi 1	Homo sapiens	16-23
10996298-6	2000	GSTP1-1 kinetics determined using HPLC indicated substrate inhibition (apparent K(m) for curcumin of 25+/-11 microM, and apparent K(i) for curcumin of 8+/-3 microM).	Curcumin	89-97	glutathione S-transferase pi 1	Homo sapiens	0-7
10996298-6	2000	GSTP1-1 kinetics determined using HPLC indicated substrate inhibition (apparent K(m) for curcumin of 25+/-11 microM, and apparent K(i) for curcumin of 8+/-3 microM).	Curcumin	139-147	glutathione S-transferase pi 1	Homo sapiens	0-7
10996298-7	2000	GSTP1-1 was also shown to catalyze the reverse reaction leading to the formation of curcumin from GSH adducts of FMK and FAL.	Curcumin	84-92	glutathione S-transferase pi 1	Homo sapiens	0-7
10996298-7	2000	GSTP1-1 was also shown to catalyze the reverse reaction leading to the formation of curcumin from GSH adducts of FMK and FAL.	Glutathione	98-101	glutathione S-transferase pi 1	Homo sapiens	0-7
10880766-0	2000	Expression of hGSTP1 alleles in human lung and catalytic activity of the native protein variants towards 1-chloro-2,4-dinitrobenzene, 4-vinylpyridine and (+)-anti benzo[a]pyrene-7,8-diol-9,10-oxide.	Dinitrochlorobenzene	105-132	glutathione S-transferase pi 1	Homo sapiens	14-20
10880766-0	2000	Expression of hGSTP1 alleles in human lung and catalytic activity of the native protein variants towards 1-chloro-2,4-dinitrobenzene, 4-vinylpyridine and (+)-anti benzo[a]pyrene-7,8-diol-9,10-oxide.	4-vinylpyridine	134-149	glutathione S-transferase pi 1	Homo sapiens	14-20
10880766-0	2000	Expression of hGSTP1 alleles in human lung and catalytic activity of the native protein variants towards 1-chloro-2,4-dinitrobenzene, 4-vinylpyridine and (+)-anti benzo[a]pyrene-7,8-diol-9,10-oxide.	pyrene-7,8-diol-9,10-oxide	171-197	glutathione S-transferase pi 1	Homo sapiens	14-20
10880766-1	2000	The human glutathione S-transferase (GST) P1 alleles coding for Val(105) (hGSTP1*B and/or P1*C) are over- represented in lung cancer patients.	Valine	64-67	glutathione S-transferase pi 1	Homo sapiens	10-44
10880766-1	2000	The human glutathione S-transferase (GST) P1 alleles coding for Val(105) (hGSTP1*B and/or P1*C) are over- represented in lung cancer patients.	Valine	64-67	glutathione S-transferase pi 1	Homo sapiens	74-80
10860939-4	2000	Cross-resistance to melphalan occurred, but not to doxorubicin (Adriamycin), taxol, and gamma-glutamyl-S-(benzyl)cysteinyl-R(-)-phenyl glycine diethyl ester, a GSTP1-1 inhibitor.	Melphalan	20-29	glutathione S-transferase pi 1	Homo sapiens	160-167
10814878-8	2000	The expression of QR and GSTP1-1 proteins were increased by 3 to 4-fold and 3 to 5-fold, respectively, for MCF-10F cells treated with sulforaphane (0.5-2.0 microM).	sulforaphane	134-146	glutathione S-transferase pi 1	Homo sapiens	25-32
10909855-0	2000	Extended structural variation of a pentanucleotide repeat in the GSTP1 gene: characterisation in a normal population and in thyroid and gastric tumours.	pentanucleotide	35-50	glutathione S-transferase pi 1	Homo sapiens	65-70
10860939-11	2000	These results are consistent with responses in the TER286-resistant cells indicative of GSTP1-1-mediated mechanism of activation.	TER 286	51-57	glutathione S-transferase pi 1	Homo sapiens	88-95
10799737-1	2000	The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined.	Glutathione	60-71	glutathione S-transferase pi 1	Homo sapiens	96-104
10799737-1	2000	The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined.	Glutathione	73-76	glutathione S-transferase pi 1	Homo sapiens	96-104
10799737-1	2000	The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined.	Isoleucine	185-195	glutathione S-transferase pi 1	Homo sapiens	96-104
10799737-1	2000	The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined.	Valine	199-205	glutathione S-transferase pi 1	Homo sapiens	96-104
10799737-1	2000	The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined.	Alanine	219-226	glutathione S-transferase pi 1	Homo sapiens	96-104
10799737-1	2000	The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined.	Valine	230-236	glutathione S-transferase pi 1	Homo sapiens	96-104
10799737-1	2000	The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined.	Glutathione	246-249	glutathione S-transferase pi 1	Homo sapiens	96-104
10799737-1	2000	The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined.	Acrolein	282-290	glutathione S-transferase pi 1	Homo sapiens	96-104
10799737-1	2000	The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined.	2-butenal	295-309	glutathione S-transferase pi 1	Homo sapiens	96-104
10799737-2	2000	The k(cat)/K(m) values for hGSTP1-1 isoforms I104,A113 (IA), I104, V113 (IV), V104,A113 (VA) and V104,V113 (VV) toward acrolein were 129+/-3, 116+/-3, 128+/-4 and 92+/-3 mM(-1) s(-1), respectively.	Acrolein	119-127	glutathione S-transferase pi 1	Homo sapiens	27-35
10799737-3	2000	The catalytic efficiencies of the hGSTP1-1 variants IA, IV, and VA in the GSH conjugation of acrolein were statistically significantly higher (at P=0.05) compared with the VV isoform.	Glutathione	74-77	glutathione S-transferase pi 1	Homo sapiens	34-42
10799737-3	2000	The catalytic efficiencies of the hGSTP1-1 variants IA, IV, and VA in the GSH conjugation of acrolein were statistically significantly higher (at P=0.05) compared with the VV isoform.	Acrolein	93-101	glutathione S-transferase pi 1	Homo sapiens	34-42
10799737-4	2000	On the other hand, the catalytic efficiencies of the hGSTP1-1 isoforms IA, IV, VA and VV toward crotonaldehyde (16+/-2, 12+/-1, 17+/-2, and 12+/-2 mM(-1)s(-1), respectively) were not statistically significantly different from each other.	2-butenal	96-110	glutathione S-transferase pi 1	Homo sapiens	53-61
10799737-5	2000	Our results suggest that hGSTP1-1 polymorphism may be an important factor in differential susceptibility of individuals to the toxic effects of acrolein, which is a widely spread environmental pollutant and generated endogenously during metabolic activation of anticancer drug cyclophosphamide.	Acrolein	144-152	glutathione S-transferase pi 1	Homo sapiens	25-33
10799737-5	2000	Our results suggest that hGSTP1-1 polymorphism may be an important factor in differential susceptibility of individuals to the toxic effects of acrolein, which is a widely spread environmental pollutant and generated endogenously during metabolic activation of anticancer drug cyclophosphamide.	Cyclophosphamide	277-293	glutathione S-transferase pi 1	Homo sapiens	25-33
10692562-3	2000	Thus, we have developed glutathione phosphono analogs [(S)-gamma-glutamyl-(2RS)-(+/-)-2-amino-(dialkoxyphosphinyl)-ac etylgl ycines], which were previously shown to be inhibitors of GSTP1-1.	glutathione phosphono	24-45	glutathione S-transferase pi 1	Homo sapiens	182-189
10870112-10	2000	RESULTS: GSTP1 expression was higher than other GSTs in 13/14 cell lines and paralleled CDNB conjugation activity.	Dinitrochlorobenzene	88-92	glutathione S-transferase pi 1	Homo sapiens	9-14
10744731-7	2000	In P(i) class GSTs, Tyr(154) appears to be of particular structural importance, since it interacts with conserved residues Leu(21), Asp(24), and Gln(25) of the adjacent alpha1-helix which contributes to the active site.	Tyrosine	20-23	glutathione S-transferase pi 1	Homo sapiens	14-18
10744731-7	2000	In P(i) class GSTs, Tyr(154) appears to be of particular structural importance, since it interacts with conserved residues Leu(21), Asp(24), and Gln(25) of the adjacent alpha1-helix which contributes to the active site.	Leucine	123-126	glutathione S-transferase pi 1	Homo sapiens	14-18
10744731-7	2000	In P(i) class GSTs, Tyr(154) appears to be of particular structural importance, since it interacts with conserved residues Leu(21), Asp(24), and Gln(25) of the adjacent alpha1-helix which contributes to the active site.	Aspartic Acid	132-135	glutathione S-transferase pi 1	Homo sapiens	14-18
10744731-7	2000	In P(i) class GSTs, Tyr(154) appears to be of particular structural importance, since it interacts with conserved residues Leu(21), Asp(24), and Gln(25) of the adjacent alpha1-helix which contributes to the active site.	Glutamine	145-148	glutathione S-transferase pi 1	Homo sapiens	14-18
10692562-3	2000	Thus, we have developed glutathione phosphono analogs [(S)-gamma-glutamyl-(2RS)-(+/-)-2-amino-(dialkoxyphosphinyl)-ac etylgl ycines], which were previously shown to be inhibitors of GSTP1-1.	(s)-gamma-glutamyl-(2rs)-(+/-)-2-amino-(dialkoxyphosphinyl)-ac etylgl ycines	55-131	glutathione S-transferase pi 1	Homo sapiens	182-189
10692562-5	2000	The inhibition of class alpha GSTs was competitive towards GSH.	Glutathione	59-62	glutathione S-transferase pi 1	Homo sapiens	30-34
10766427-0	2000	Increased formation of oxidative DNA damage, 8-hydroxy-2"-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes.	8-ohdg	45-72	glutathione S-transferase pi 1	Homo sapiens	128-133
10666194-0	2000	Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study.	Glutathione	21-32	glutathione S-transferase pi 1	Homo sapiens	68-73
10766427-10	2000	Furthermore, patients with genotype of high GSTP1 activity had lower level of 8-OHdG in DNA of breast cancer tissues than others.	8-ohdg	78-84	glutathione S-transferase pi 1	Homo sapiens	44-49
10717233-2	2000	We report here that the pathogenesis of hepatocellular carcinoma (HCC), one of the most common cancers in the world, frequently involves an accumulation of somatic <CpG island> DNA methylation changes at GSTP1, the gene encoding the pi-class glutathione S-transferase.	Glutathione	248-259	glutathione S-transferase pi 1	Homo sapiens	210-215
10717233-8	2000	Treatment of Hep3B HCC cells in vitro with the DNA methyltransferase inhibitor 5-aza-deoxycytidine both reversed GSTP1 <CpG island> DNA hypermethylation and restored GSTP1 expression.	Decitabine	79-98	glutathione S-transferase pi 1	Homo sapiens	113-118
10717233-8	2000	Treatment of Hep3B HCC cells in vitro with the DNA methyltransferase inhibitor 5-aza-deoxycytidine both reversed GSTP1 <CpG island> DNA hypermethylation and restored GSTP1 expression.	Decitabine	79-98	glutathione S-transferase pi 1	Homo sapiens	172-177
10760946-2	2000	The effects of the changes in MTase levels on global genomic DNA methylation and on the methylation status of CpG dinucleotides in the GSTP1 gene were determined in a glioma cell line that overexpresses the GSTP1 gene.	Dinucleoside Phosphates	114-127	glutathione S-transferase pi 1	Homo sapiens	135-140
10692504-1	2000	gamma-L-Glutamyl-S-(benzyl)-L-cysteinyl-R-(-)-phenylglycine (TER 117) has previously been developed for selective inhibition of human glutathione S-transferase P1-1 (GST P1-1) based on the postulated contribution of this isoenzyme to the development of drug resistance in cancer cells.	gamma-l-glutamyl-s-(benzyl)-l-cysteinyl-r-(-)-phenylglycine	0-59	glutathione S-transferase pi 1	Homo sapiens	166-174
10692504-1	2000	gamma-L-Glutamyl-S-(benzyl)-L-cysteinyl-R-(-)-phenylglycine (TER 117) has previously been developed for selective inhibition of human glutathione S-transferase P1-1 (GST P1-1) based on the postulated contribution of this isoenzyme to the development of drug resistance in cancer cells.	Glutathione	134-145	glutathione S-transferase pi 1	Homo sapiens	166-174
10717233-10	2000	Genomic sequencing analyses, undertaken to map 5-methyldeoxycytidine nucleotides located at the GSTP1 transcriptional regulatory region, frequently detected somatic DNA hypermethylation near the gene promoter in HCC DNA.	5-methyldeoxycytidine nucleotides	47-80	glutathione S-transferase pi 1	Homo sapiens	96-101
10536361-1	1999	The ability of retinoic acid to modulate glutathione S-transferase P1-1 (GSTP1-1) activity has important implications both for cancer prevention and for anticancer therapy.	Tretinoin	15-28	glutathione S-transferase pi 1	Homo sapiens	73-80
10698483-0	2000	Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms.	Polycyclic Aromatic Hydrocarbons	20-51	glutathione S-transferase pi 1	Homo sapiens	116-144
10698483-5	2000	GSTP1 catalyzes the detoxification of PAH; the val allele has greater catalytic efficiency toward PAH diol epoxides.	Valine	47-50	glutathione S-transferase pi 1	Homo sapiens	0-5
10712743-2	2000	GSTP1 and GSTM1 are mainly involved in detoxification reactions of PAH carcinogenic intermediates produced by cytochrome P450 (CYP).	p-Aminohippuric Acid	67-70	glutathione S-transferase pi 1	Homo sapiens	0-5
10712743-4	2000	In this study, we examined the effect of common polymorphism in exon 5 (105Ile --> Val) of the GSTP1 gene, alone and in combination with GSTM1-deletion polymorphism, on the level of PAH-DNA adducts measured by (32)P-postlabeling assay in mononuclear white blood cells collected in winter and in summer from a total of 170 healthy volunteers.	p-Aminohippuric Acid	185-188	glutathione S-transferase pi 1	Homo sapiens	98-103
10712743-10	2000	Our data show that the combined GSTM1 and GSTP1 genetic polymorphisms may modulate PAH-DNA adduct levels in mononuclear WBCs from individuals exposed to specific carcinogenic compounds, e.g., tobacco smoke, in relatively lower-exposure environmental conditions (i.e., in summer).	p-Aminohippuric Acid	83-86	glutathione S-transferase pi 1	Homo sapiens	42-47
10789228-2	2000	The report discusses data on a relationship between progesterone (PS) inhibition of GST P1-1 and proliferation of human erythroleukemia K562 cells.	Progesterone	52-64	glutathione S-transferase pi 1	Homo sapiens	84-92
10789228-3	2000	Unlike such steroids as estrone, dexamethasone, testosterone and hydrocortisone, PS showed significant inhibitory effect (I50 = 32.5(M) and noncompetitively (Ki = 25(M) inhibited GST P1-1 isolated from human placenta.	Progesterone	81-83	glutathione S-transferase pi 1	Homo sapiens	179-187
10789228-4	2000	Pronounced inhibition of K562 cell proliferation by PS was in inverse correlation with the intracellular activity of GST P1-1.	Progesterone	52-54	glutathione S-transferase pi 1	Homo sapiens	117-125
10789228-5	2000	Also, PS injected into culture suppressed GST P1-1 expression in leukemia cells.	Progesterone	6-8	glutathione S-transferase pi 1	Homo sapiens	42-50
10789228-7	2000	The correlation between PS antiproliferative effect on GST P1-1 activity and expression in K562 cells is discussed in terms of its possible role played in malignant growth regulation.	Progesterone	24-26	glutathione S-transferase pi 1	Homo sapiens	55-63
10919500-8	2000	The implication of specific polymorphisms at the GSTP1 locus in airway inflammation is entirely novel: however, GST are recognized as a supergene family of enzymes critical in 1) cell protection from the toxic products of ROS-mediated reactions, 2) modulation of eicosanoid synthesis.	Reactive Oxygen Species	222-225	glutathione S-transferase pi 1	Homo sapiens	49-54
10919500-8	2000	The implication of specific polymorphisms at the GSTP1 locus in airway inflammation is entirely novel: however, GST are recognized as a supergene family of enzymes critical in 1) cell protection from the toxic products of ROS-mediated reactions, 2) modulation of eicosanoid synthesis.	Eicosanoids	263-273	glutathione S-transferase pi 1	Homo sapiens	49-54
10536361-2	1999	We investigated GSTP1-1 expression and activity in the human neuroblastoma cell line SK-N-BE(2) (genotype A*/B*) under basal conditions and during 48-h incubation with 0.1 microM all-trans-retinoic acid.	sk-n-be	85-92	glutathione S-transferase pi 1	Homo sapiens	16-23
10536361-2	1999	We investigated GSTP1-1 expression and activity in the human neuroblastoma cell line SK-N-BE(2) (genotype A*/B*) under basal conditions and during 48-h incubation with 0.1 microM all-trans-retinoic acid.	Tretinoin	179-202	glutathione S-transferase pi 1	Homo sapiens	16-23
10536361-4	1999	This reduction in enzymatic activity could not be ascribed to a differential action of retinoic acid on the gene variants A* and B*; indeed, the two GSTP1-1 isoforms have different affinities toward 1-chloro-2,4-dinitrobenzene (CDNB), while we found a substantial invariance of the K(m) (CDNB) in the cytosol during retinoid treatment.	Tretinoin	87-100	glutathione S-transferase pi 1	Homo sapiens	149-156
10536361-4	1999	This reduction in enzymatic activity could not be ascribed to a differential action of retinoic acid on the gene variants A* and B*; indeed, the two GSTP1-1 isoforms have different affinities toward 1-chloro-2,4-dinitrobenzene (CDNB), while we found a substantial invariance of the K(m) (CDNB) in the cytosol during retinoid treatment.	Dinitrochlorobenzene	199-226	glutathione S-transferase pi 1	Homo sapiens	149-156
10536361-4	1999	This reduction in enzymatic activity could not be ascribed to a differential action of retinoic acid on the gene variants A* and B*; indeed, the two GSTP1-1 isoforms have different affinities toward 1-chloro-2,4-dinitrobenzene (CDNB), while we found a substantial invariance of the K(m) (CDNB) in the cytosol during retinoid treatment.	Dinitrochlorobenzene	228-232	glutathione S-transferase pi 1	Homo sapiens	149-156
10536361-4	1999	This reduction in enzymatic activity could not be ascribed to a differential action of retinoic acid on the gene variants A* and B*; indeed, the two GSTP1-1 isoforms have different affinities toward 1-chloro-2,4-dinitrobenzene (CDNB), while we found a substantial invariance of the K(m) (CDNB) in the cytosol during retinoid treatment.	Dinitrochlorobenzene	288-292	glutathione S-transferase pi 1	Homo sapiens	149-156
10536361-4	1999	This reduction in enzymatic activity could not be ascribed to a differential action of retinoic acid on the gene variants A* and B*; indeed, the two GSTP1-1 isoforms have different affinities toward 1-chloro-2,4-dinitrobenzene (CDNB), while we found a substantial invariance of the K(m) (CDNB) in the cytosol during retinoid treatment.	Retinoids	316-324	glutathione S-transferase pi 1	Homo sapiens	149-156
10536361-5	1999	A modulatory effect of retinoic acid on other enzymes involved in glutathione transferase P1-1 metabolism, such as the retinoic acid-induced tissue trans-glutaminase, might be hypothesized, as well as a direct inactivation of GSTP1-1 by the oxidative stress that characterizes the early phases of apoptosis.	Tretinoin	23-36	glutathione S-transferase pi 1	Homo sapiens	226-233
10536361-5	1999	A modulatory effect of retinoic acid on other enzymes involved in glutathione transferase P1-1 metabolism, such as the retinoic acid-induced tissue trans-glutaminase, might be hypothesized, as well as a direct inactivation of GSTP1-1 by the oxidative stress that characterizes the early phases of apoptosis.	Tretinoin	119-132	glutathione S-transferase pi 1	Homo sapiens	226-233
10434361-4	1999	From statistical evaluation on various combinations of genotypes, we observed that the cancer risk of those who have both GSTM1 present genotype and GSTP1 Adenine/Adenine homozygous genotype was significantly less than those who have other combinations of genotypes for two genes.	Adenine	155-162	glutathione S-transferase pi 1	Homo sapiens	149-154
10441116-1	1999	Two variants of human class pi glutathione (GSH) S-transferase 1-1 with either isoleucine or valine in position 104 (hGSTP1-1[I104] and hGSTP1-1[V104]) have distinct activity toward (+)-anti-7, 8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-anti-BPDE].	Glutathione	44-47	glutathione S-transferase pi 1	Homo sapiens	117-123
10441116-4	1999	First, the distance between the hydroxyl group of Y7 and the sulfur atom of GSBpd is 5.9 A in the hGSTP1-1[I104].GSBpd complex versus 3.2 A in the V104 variant.	Sulfur	61-67	glutathione S-transferase pi 1	Homo sapiens	98-104
10441116-5	1999	Second, one of the hydroxyl groups of GSBpd forms a direct hydrogen bond with R13 in hGSTP1-1[V104].GSBpd; in contrast, this hydrogen bond is not observed in the I104 complex.	Hydrogen	59-67	glutathione S-transferase pi 1	Homo sapiens	85-91
10383436-4	1999	In fact, above 35 degrees C, glutathione (GSH) binding to GST P1-1 displays positive cooperativity, whereas negative cooperativity occurs below 25 degrees C. This binding mechanism minimizes changes of GSH affinity for GST P1-1 because of temperature fluctuation.	Glutathione	29-40	glutathione S-transferase pi 1	Homo sapiens	58-66
10383436-4	1999	In fact, above 35 degrees C, glutathione (GSH) binding to GST P1-1 displays positive cooperativity, whereas negative cooperativity occurs below 25 degrees C. This binding mechanism minimizes changes of GSH affinity for GST P1-1 because of temperature fluctuation.	Glutathione	29-40	glutathione S-transferase pi 1	Homo sapiens	219-227
10383436-4	1999	In fact, above 35 degrees C, glutathione (GSH) binding to GST P1-1 displays positive cooperativity, whereas negative cooperativity occurs below 25 degrees C. This binding mechanism minimizes changes of GSH affinity for GST P1-1 because of temperature fluctuation.	Glutathione	42-45	glutathione S-transferase pi 1	Homo sapiens	58-66
10383436-4	1999	In fact, above 35 degrees C, glutathione (GSH) binding to GST P1-1 displays positive cooperativity, whereas negative cooperativity occurs below 25 degrees C. This binding mechanism minimizes changes of GSH affinity for GST P1-1 because of temperature fluctuation.	Glutathione	42-45	glutathione S-transferase pi 1	Homo sapiens	219-227
10383436-4	1999	In fact, above 35 degrees C, glutathione (GSH) binding to GST P1-1 displays positive cooperativity, whereas negative cooperativity occurs below 25 degrees C. This binding mechanism minimizes changes of GSH affinity for GST P1-1 because of temperature fluctuation.	Glutathione	202-205	glutathione S-transferase pi 1	Homo sapiens	58-66
10383436-4	1999	In fact, above 35 degrees C, glutathione (GSH) binding to GST P1-1 displays positive cooperativity, whereas negative cooperativity occurs below 25 degrees C. This binding mechanism minimizes changes of GSH affinity for GST P1-1 because of temperature fluctuation.	Glutathione	202-205	glutathione S-transferase pi 1	Homo sapiens	219-227
10383436-6	1999	As a whole, GST P1-1 represents the first enzyme which displays a temperature-dependent homotropic regulation of substrate (e.g. GSH) binding.	Glutathione	129-132	glutathione S-transferase pi 1	Homo sapiens	12-20
10353259-2	1999	The glutathione-related metabolism of PGA2 was therefore investigated both with purified glutathione S-transferase P1-1 (GSTP1-1) and with IGR-39 human melanoma cells.	Glutathione	4-15	glutathione S-transferase pi 1	Homo sapiens	121-128
10353259-2	1999	The glutathione-related metabolism of PGA2 was therefore investigated both with purified glutathione S-transferase P1-1 (GSTP1-1) and with IGR-39 human melanoma cells.	prostaglandin A2	38-42	glutathione S-transferase pi 1	Homo sapiens	121-128
10353259-4	1999	PGA2 appeared to inhibit GSTP1-1 mainly by binding to the cysteine 47 moiety of the enzyme.	prostaglandin A2	0-4	glutathione S-transferase pi 1	Homo sapiens	25-32
10353259-4	1999	PGA2 appeared to inhibit GSTP1-1 mainly by binding to the cysteine 47 moiety of the enzyme.	Cysteine	58-66	glutathione S-transferase pi 1	Homo sapiens	25-32
10353259-6	1999	Secondly, after exposing IGR-39 human melanoma cells to PGA2, both diastereoisomers of the PGA2-glutathione conjugate are excreted into the medium, although with a clear excess of the S-form, due to its preferential formation by the GSTP1-1 present in the cells.	prostaglandin A2	56-60	glutathione S-transferase pi 1	Homo sapiens	233-240
10353259-6	1999	Secondly, after exposing IGR-39 human melanoma cells to PGA2, both diastereoisomers of the PGA2-glutathione conjugate are excreted into the medium, although with a clear excess of the S-form, due to its preferential formation by the GSTP1-1 present in the cells.	pga2-glutathione	91-107	glutathione S-transferase pi 1	Homo sapiens	233-240
10353259-10	1999	In conclusion, PGA2 modulates all three aspects of the glutathione-mediated biotransformation system, i.e. GSH levels, GSTP1-1 activity, and transport of GSH conjugates.	prostaglandin A2	15-19	glutathione S-transferase pi 1	Homo sapiens	119-126
10353259-10	1999	In conclusion, PGA2 modulates all three aspects of the glutathione-mediated biotransformation system, i.e. GSH levels, GSTP1-1 activity, and transport of GSH conjugates.	Glutathione	55-66	glutathione S-transferase pi 1	Homo sapiens	119-126
10600464-1	1999	The bacterial expression and purification of human pi class glutathione S-transferase (hGST P1-1) as a hexahistidine-tagged polypeptide was performed.	His-His-His-His-His-His	103-116	glutathione S-transferase pi 1	Homo sapiens	87-96
10600464-6	1999	It showed that the real molecular weight of the hexahistidine-tagged hGST P1-1 polypeptide chain agreed with the calculated value and that the purified protein eluted as an apparent homodimer on the gel filtration column.	His-His-His-His-His-His	48-61	glutathione S-transferase pi 1	Homo sapiens	69-78
10600464-7	1999	Our expression system allows the expression and purification of active hexahistidine-tagged hGST P1-1 in high yield with no need of removal of the hexahistidine tag and gives pure protein in one purification step allowing further study of this enzyme.	His-His-His-His-His-His	71-84	glutathione S-transferase pi 1	Homo sapiens	92-101
10600464-7	1999	Our expression system allows the expression and purification of active hexahistidine-tagged hGST P1-1 in high yield with no need of removal of the hexahistidine tag and gives pure protein in one purification step allowing further study of this enzyme.	His-His-His-His-His-His	147-160	glutathione S-transferase pi 1	Homo sapiens	92-101
10334868-3	1999	Increased glutathione (GSH) conjugation through catalysis by GSH S-transferases (GSTs) is believed to be an important mechanism in tumor cell resistance to alkylating agents.	Glutathione	10-21	glutathione S-transferase pi 1	Homo sapiens	81-85
10334868-3	1999	Increased glutathione (GSH) conjugation through catalysis by GSH S-transferases (GSTs) is believed to be an important mechanism in tumor cell resistance to alkylating agents.	Glutathione	23-26	glutathione S-transferase pi 1	Homo sapiens	81-85
10334868-4	1999	In the present study, we report that the allelic variants of human Pi class GST (hGSTP1-1), which differ in their primary structures at amino acids in positions 104 and/or 113, exhibit significant differences in their activity in the GSH conjugation of alkylating anticancer drug thiotepa.	Glutathione	234-237	glutathione S-transferase pi 1	Homo sapiens	81-89
10334868-4	1999	In the present study, we report that the allelic variants of human Pi class GST (hGSTP1-1), which differ in their primary structures at amino acids in positions 104 and/or 113, exhibit significant differences in their activity in the GSH conjugation of alkylating anticancer drug thiotepa.	Thiotepa	280-288	glutathione S-transferase pi 1	Homo sapiens	81-89
10334868-6	1999	While nonenzymatic formation of monoglutathionyl-thiotepa was negligible, the formation of this conjugate was increased significantly in the presence of hGSTP1-1 protein.	monoglutathionyl-thiotepa	32-57	glutathione S-transferase pi 1	Homo sapiens	153-161
10334868-7	1999	The hGSTP1-1-catalyzed GSH conjugation of thiotepa was time and protein dependent and followed Michaelis-Menten kinetics.	Glutathione	23-26	glutathione S-transferase pi 1	Homo sapiens	4-10
10334868-7	1999	The hGSTP1-1-catalyzed GSH conjugation of thiotepa was time and protein dependent and followed Michaelis-Menten kinetics.	Thiotepa	42-50	glutathione S-transferase pi 1	Homo sapiens	4-10
10334868-9	1999	The results of the present study indicate that the hGSTP1-1 polymorphism may be an important factor in GST-mediated tumor cell resistance to thiotepa, and that subjects homozygous for the hGSTP1-1(I104,A113) allele, which is most frequent in human populations, are likely to be at a greater risk for developing GST-mediated resistance to thiotepa than heterozygotes or homozygotes with valine 104 background.	Thiotepa	141-149	glutathione S-transferase pi 1	Homo sapiens	51-59
10434361-4	1999	From statistical evaluation on various combinations of genotypes, we observed that the cancer risk of those who have both GSTM1 present genotype and GSTP1 Adenine/Adenine homozygous genotype was significantly less than those who have other combinations of genotypes for two genes.	Adenine	163-170	glutathione S-transferase pi 1	Homo sapiens	149-154
10366541-7	1999	Combined expression of GST P1-1 and MRP1 increased the rates of DNP-SG formation when cells were exposed to 10 microM CDNB.	2,4-Dinitrophenol	64-67	glutathione S-transferase pi 1	Homo sapiens	23-31
10366541-1	1999	We examined the roles of glutathione S-transferase (GST) P1-1 and the glutathione S-conjugate (GS-X) transporter, multidrug resistance protein 1 (MRP1), singly or in combination, in the detoxification of 1-chloro-2,4-dinitrobenzene (CDNB).	Dinitrochlorobenzene	204-231	glutathione S-transferase pi 1	Homo sapiens	25-61
10366541-4	1999	MRP1 expression in the absence of GST P1-1 confers a three- to fourfold resistance to CDNB, which is associated with a >10-fold increase in the maximum rate of DNP-SG efflux.	Dinitrochlorobenzene	86-90	glutathione S-transferase pi 1	Homo sapiens	34-40
10366541-7	1999	Combined expression of GST P1-1 and MRP1 increased the rates of DNP-SG formation when cells were exposed to 10 microM CDNB.	Dinitrochlorobenzene	118-122	glutathione S-transferase pi 1	Homo sapiens	23-31
10366541-8	1999	Moreover, combined expression of GSTP1-1 with MRP1 moderately augmented MRP1-mediated resistance to CDNB but only during short term (10 min) exposures to CDNB where IC50 values were in the 8-10 microM range.	Dinitrochlorobenzene	100-104	glutathione S-transferase pi 1	Homo sapiens	33-40
10366541-8	1999	Moreover, combined expression of GSTP1-1 with MRP1 moderately augmented MRP1-mediated resistance to CDNB but only during short term (10 min) exposures to CDNB where IC50 values were in the 8-10 microM range.	Dinitrochlorobenzene	154-158	glutathione S-transferase pi 1	Homo sapiens	33-40
10366541-9	1999	In contrast, expression of GST P1-1 in the absence of MRP1 slightly sensitized cells to the toxicity of CDNB (10 min exposures), despite increasing rates of DNP-SG formation.	Dinitrochlorobenzene	104-108	glutathione S-transferase pi 1	Homo sapiens	27-35
10366541-9	1999	In contrast, expression of GST P1-1 in the absence of MRP1 slightly sensitized cells to the toxicity of CDNB (10 min exposures), despite increasing rates of DNP-SG formation.	2,4-Dinitrophenol	157-160	glutathione S-transferase pi 1	Homo sapiens	27-35
10366541-10	1999	The sensitization to CDNB in cells expressing GST P1-1 alone was associated with increased intracellular accumulation of DNP-SG, indicating that DNP-SG may contribute to CDNB toxicity.	Dinitrochlorobenzene	21-25	glutathione S-transferase pi 1	Homo sapiens	46-54
10366541-10	1999	The sensitization to CDNB in cells expressing GST P1-1 alone was associated with increased intracellular accumulation of DNP-SG, indicating that DNP-SG may contribute to CDNB toxicity.	2,4-Dinitrophenol	121-124	glutathione S-transferase pi 1	Homo sapiens	46-54
10366541-10	1999	The sensitization to CDNB in cells expressing GST P1-1 alone was associated with increased intracellular accumulation of DNP-SG, indicating that DNP-SG may contribute to CDNB toxicity.	2,4-Dinitrophenol	145-148	glutathione S-transferase pi 1	Homo sapiens	46-54
10366541-10	1999	The sensitization to CDNB in cells expressing GST P1-1 alone was associated with increased intracellular accumulation of DNP-SG, indicating that DNP-SG may contribute to CDNB toxicity.	Dinitrochlorobenzene	170-174	glutathione S-transferase pi 1	Homo sapiens	46-54
10344744-1	1999	The pi class glutathione S-transferase (GSTP1-1), which is polymorphic in human populations, is believed to play an important role in detoxification of the ultimate carcinogen of widespread environmental pollutant benzo[a]pyrene [(+)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide [(+)-anti-BPDE]].	(+)-anti-bpde	284-297	glutathione S-transferase pi 1	Homo sapiens	40-47
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Isoleucine	113-123	glutathione S-transferase pi 1	Homo sapiens	30-37
10344744-1	1999	The pi class glutathione S-transferase (GSTP1-1), which is polymorphic in human populations, is believed to play an important role in detoxification of the ultimate carcinogen of widespread environmental pollutant benzo[a]pyrene [(+)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide [(+)-anti-BPDE]].	pyrene	222-228	glutathione S-transferase pi 1	Homo sapiens	40-47
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Isoleucine	113-123	glutathione S-transferase pi 1	Homo sapiens	39-47
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Valine	127-133	glutathione S-transferase pi 1	Homo sapiens	30-37
10344744-1	1999	The pi class glutathione S-transferase (GSTP1-1), which is polymorphic in human populations, is believed to play an important role in detoxification of the ultimate carcinogen of widespread environmental pollutant benzo[a]pyrene [(+)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide [(+)-anti-BPDE]].	(+)-anti-benzo[	230-245	glutathione S-transferase pi 1	Homo sapiens	40-47
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Valine	127-133	glutathione S-transferase pi 1	Homo sapiens	39-47
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Valine	147-153	glutathione S-transferase pi 1	Homo sapiens	30-37
10344744-1	1999	The pi class glutathione S-transferase (GSTP1-1), which is polymorphic in human populations, is believed to play an important role in detoxification of the ultimate carcinogen of widespread environmental pollutant benzo[a]pyrene [(+)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide [(+)-anti-BPDE]].	pyrene-7,8-dihydrodiol-9,10-epoxide	247-282	glutathione S-transferase pi 1	Homo sapiens	40-47
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Valine	147-153	glutathione S-transferase pi 1	Homo sapiens	39-47
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Alanine	157-164	glutathione S-transferase pi 1	Homo sapiens	30-37
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Alanine	157-164	glutathione S-transferase pi 1	Homo sapiens	39-47
10350652-11	1999	GSH homeostasis thus appears to be maintained by an interaction between GSTP1 and GCS in human hepatic cells resistant to the GSH poison.	Glutathione	0-3	glutathione S-transferase pi 1	Homo sapiens	72-77
10344744-3	1999	Here, we have determined the protective effect of overexpression of allelic variants of hGSTP1-1, through stable transfection in HepG2 cells, against (+)-anti-BPDE-induced DNA modification.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	159-163	glutathione S-transferase pi 1	Homo sapiens	88-96
10350652-11	1999	GSH homeostasis thus appears to be maintained by an interaction between GSTP1 and GCS in human hepatic cells resistant to the GSH poison.	Glutathione	126-129	glutathione S-transferase pi 1	Homo sapiens	72-77
10344744-5	1999	The glutathione S-transferase activity toward (+)-anti-BPDE was significantly higher (approximately 3.0-3.6-fold) in cells transfected with hGSTP1(VA) [HepG2(VA)] and hGSTP1(VV) [HepG2(VV)] compared with hGSTP1(IA) transfectant [HepG2(IA)].	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	55-59	glutathione S-transferase pi 1	Homo sapiens	140-146
10344744-5	1999	The glutathione S-transferase activity toward (+)-anti-BPDE was significantly higher (approximately 3.0-3.6-fold) in cells transfected with hGSTP1(VA) [HepG2(VA)] and hGSTP1(VV) [HepG2(VV)] compared with hGSTP1(IA) transfectant [HepG2(IA)].	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	55-59	glutathione S-transferase pi 1	Homo sapiens	167-173
10344744-5	1999	The glutathione S-transferase activity toward (+)-anti-BPDE was significantly higher (approximately 3.0-3.6-fold) in cells transfected with hGSTP1(VA) [HepG2(VA)] and hGSTP1(VV) [HepG2(VV)] compared with hGSTP1(IA) transfectant [HepG2(IA)].	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	55-59	glutathione S-transferase pi 1	Homo sapiens	167-173
10344744-7	1999	Maximum protection against (+)-anti-BPDE-induced DNA damage was afforded by the hGSTP1(VV) isoform.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	36-40	glutathione S-transferase pi 1	Homo sapiens	80-86
10344744-8	1999	The results of this study indicate that the allelic variants of hGSTP1-1 significantly differ in their ability to provide protection against (+)-anti-BPDE-induced DNA damage.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	150-154	glutathione S-transferase pi 1	Homo sapiens	64-72
10344744-9	1999	Thus, hGSTP1-1 polymorphism may be an important factor in differential susceptibility of individuals to tumorigenesis induced by benzo[a]pyrene.	Benzo(a)pyrene	129-143	glutathione S-transferase pi 1	Homo sapiens	6-14
10022813-1	1999	Glutathione-S-Transferases (GSTs) comprise a family of isoenzymes that provide protection to mammalian cells against electrophilic metabolites of carcinogens and reactive oxygen species.	Reactive Oxygen Species	162-185	glutathione S-transferase pi 1	Homo sapiens	28-32
10334644-1	1999	OBJECTIVES: The human GSTTP1 gene is polymorphic with an A-->G transition in exon 5 causing a replacement 105 Ile-->Val in the GSTP1 protein.	Isoleucine	113-116	glutathione S-transferase pi 1	Homo sapiens	133-138
10334644-2	1999	The two isoforms, encoded by the alleles GSTP1*A and GSTP1*B, respectively, show different catalytic efficiencies towards some carcinogenic epoxides.	Epoxy Compounds	140-148	glutathione S-transferase pi 1	Homo sapiens	41-46
10334644-2	1999	The two isoforms, encoded by the alleles GSTP1*A and GSTP1*B, respectively, show different catalytic efficiencies towards some carcinogenic epoxides.	Epoxy Compounds	140-148	glutathione S-transferase pi 1	Homo sapiens	53-58
9973324-7	1999	The tTG-catalyzed polymerization of GST P1-1 leads to its functional inactivation and is competitively inhibited by GSH.	Glutathione	116-119	glutathione S-transferase pi 1	Homo sapiens	36-44
9882456-0	1999	Quantitative differences in the active-site hydrophobicity of five human glutathione S-transferase isoenzymes: water-soluble carcinogen-selective properties of the neoplastic GSTP1-1 species.	Glutathione	73-84	glutathione S-transferase pi 1	Homo sapiens	175-182
9882456-0	1999	Quantitative differences in the active-site hydrophobicity of five human glutathione S-transferase isoenzymes: water-soluble carcinogen-selective properties of the neoplastic GSTP1-1 species.	Water	111-116	glutathione S-transferase pi 1	Homo sapiens	175-182
9882456-1	1999	The active-site (the H-site) hydrophobicity of five human glutathione S-transferases (GSTs) was analyzed by application of linear free energy relationships (LFERs) with a series of S-alkylated glutathione inhibitors, GS(CH2)n - 1CH3 (n = 1-14).	Glutathione	58-69	glutathione S-transferase pi 1	Homo sapiens	86-90
9850062-1	1998	Four allelic variants of glutathione (GSH) S-transferase P1-1 (hGSTP1-1) that differ in their structures at amino acid(s) in position(s) 104 and/or 113 are known to exist in human populations.	Glutathione	25-36	glutathione S-transferase pi 1	Homo sapiens	63-71
9877184-0	1998	GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid.	Glutathione	37-48	glutathione S-transferase pi 1	Homo sapiens	0-7
9877184-0	1998	GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid.	Ethacrynic Acid	64-79	glutathione S-transferase pi 1	Homo sapiens	0-7
9877184-6	1998	When human melanoma cells, expressing GSTP1-1, were exposed to ethacrynic acid, diastereoisomer A was the principal conjugate formed, indicating that even at physiological pH the enzyme catalyzed reaction dominates over the chemical conjugation.	Ethacrynic Acid	63-78	glutathione S-transferase pi 1	Homo sapiens	38-45
9850062-1	1998	Four allelic variants of glutathione (GSH) S-transferase P1-1 (hGSTP1-1) that differ in their structures at amino acid(s) in position(s) 104 and/or 113 are known to exist in human populations.	Glutathione	38-41	glutathione S-transferase pi 1	Homo sapiens	63-71
9850062-3	1998	In this communication, we report that the I104,A113 allele of hGSTP1-1, which is most frequent in human populations, is also most efficient in the GSH conjugation of carcinogenic anti-diol epoxides of benzo[g]chrysene and benzo[c]phenanthrene (anti-BGCDE and anti-BCPDE, respectively).	Glutathione	147-150	glutathione S-transferase pi 1	Homo sapiens	62-70
9850062-3	1998	In this communication, we report that the I104,A113 allele of hGSTP1-1, which is most frequent in human populations, is also most efficient in the GSH conjugation of carcinogenic anti-diol epoxides of benzo[g]chrysene and benzo[c]phenanthrene (anti-BGCDE and anti-BCPDE, respectively).	chrysene	209-217	glutathione S-transferase pi 1	Homo sapiens	62-70
9850062-3	1998	In this communication, we report that the I104,A113 allele of hGSTP1-1, which is most frequent in human populations, is also most efficient in the GSH conjugation of carcinogenic anti-diol epoxides of benzo[g]chrysene and benzo[c]phenanthrene (anti-BGCDE and anti-BCPDE, respectively).	phenanthrene	230-242	glutathione S-transferase pi 1	Homo sapiens	62-70
9850062-3	1998	In this communication, we report that the I104,A113 allele of hGSTP1-1, which is most frequent in human populations, is also most efficient in the GSH conjugation of carcinogenic anti-diol epoxides of benzo[g]chrysene and benzo[c]phenanthrene (anti-BGCDE and anti-BCPDE, respectively).	bgcde	249-254	glutathione S-transferase pi 1	Homo sapiens	62-70
9850062-3	1998	In this communication, we report that the I104,A113 allele of hGSTP1-1, which is most frequent in human populations, is also most efficient in the GSH conjugation of carcinogenic anti-diol epoxides of benzo[g]chrysene and benzo[c]phenanthrene (anti-BGCDE and anti-BCPDE, respectively).	bcpde	264-269	glutathione S-transferase pi 1	Homo sapiens	62-70
9850062-4	1998	The catalytic efficiency of hGSTP1-1(I104,A113) isoform toward anti-BGCDE, 0.36 mM(-1) x s(-1), was approximately 1.7-fold higher (P < 0.05) compared with hGSTP1-1(V104,V113).	bgcde	68-73	glutathione S-transferase pi 1	Homo sapiens	28-34
9850062-4	1998	The catalytic efficiency of hGSTP1-1(I104,A113) isoform toward anti-BGCDE, 0.36 mM(-1) x s(-1), was approximately 1.7-fold higher (P < 0.05) compared with hGSTP1-1(V104,V113).	bgcde	68-73	glutathione S-transferase pi 1	Homo sapiens	158-164
9850062-11	1998	In conclusion, our results suggest that hGSTP1-1 polymorphism may be an important factor in differential susceptibility of humans to cancers where polycyclic aromatic hydrocarbons are etiological factors and that I104,A113 variant may play a major role in the detoxification of nonplanar, sterically hindered fjord-region diol epoxides (e.g., anti-BGCDE).	Polycyclic Aromatic Hydrocarbons	147-179	glutathione S-transferase pi 1	Homo sapiens	40-48
9850062-11	1998	In conclusion, our results suggest that hGSTP1-1 polymorphism may be an important factor in differential susceptibility of humans to cancers where polycyclic aromatic hydrocarbons are etiological factors and that I104,A113 variant may play a major role in the detoxification of nonplanar, sterically hindered fjord-region diol epoxides (e.g., anti-BGCDE).	diol epoxides	322-335	glutathione S-transferase pi 1	Homo sapiens	40-48
9850062-11	1998	In conclusion, our results suggest that hGSTP1-1 polymorphism may be an important factor in differential susceptibility of humans to cancers where polycyclic aromatic hydrocarbons are etiological factors and that I104,A113 variant may play a major role in the detoxification of nonplanar, sterically hindered fjord-region diol epoxides (e.g., anti-BGCDE).	bgcde	348-353	glutathione S-transferase pi 1	Homo sapiens	40-48
9806904-12	1998	Under the same reaction conditions, GSTP1-1 was much less effective in catalysing the steric conversion of 9-cis-retinoic acid to t-RA, indicating that the enzyme was stereospecific for the conversion of 13-cRA to t-RA.	Tretinoin	214-218	glutathione S-transferase pi 1	Homo sapiens	36-43
9817389-11	1998	Normal basal cells express GSTP1, an enzyme that inactivates reactive electrophiles and organic hydroperoxides, and that may protect cells from deoxyribonucleic acid damaging agents.	Hydrogen Peroxide	96-110	glutathione S-transferase pi 1	Homo sapiens	27-32
9806904-13	1998	These observations suggest that enzymic catalysis was the primary mechanism for the GSTP1-1-dependent conversion of 13-cRA to t-RA.	Tretinoin	126-130	glutathione S-transferase pi 1	Homo sapiens	84-91
9806904-10	1998	Additions of polyclonal rabbit antiserum for human GSTP1-1 to the reaction resulted in a significant decrease in generation of t-RA (70-80%).	Tretinoin	127-131	glutathione S-transferase pi 1	Homo sapiens	51-58
9806904-11	1998	In addition, ethacrynic acid, a selective substrate for Pi isoforms of GST, also inhibited the isomerization of 13-cRA to t-RA catalysed by GSTP1-1.	Ethacrynic Acid	13-28	glutathione S-transferase pi 1	Homo sapiens	140-147
9806904-11	1998	In addition, ethacrynic acid, a selective substrate for Pi isoforms of GST, also inhibited the isomerization of 13-cRA to t-RA catalysed by GSTP1-1.	Tretinoin	122-126	glutathione S-transferase pi 1	Homo sapiens	140-147
9806904-12	1998	Under the same reaction conditions, GSTP1-1 was much less effective in catalysing the steric conversion of 9-cis-retinoic acid to t-RA, indicating that the enzyme was stereospecific for the conversion of 13-cRA to t-RA.	Alitretinoin	107-126	glutathione S-transferase pi 1	Homo sapiens	36-43
9806904-12	1998	Under the same reaction conditions, GSTP1-1 was much less effective in catalysing the steric conversion of 9-cis-retinoic acid to t-RA, indicating that the enzyme was stereospecific for the conversion of 13-cRA to t-RA.	Tretinoin	130-134	glutathione S-transferase pi 1	Homo sapiens	36-43
9776312-0	1998	Combined expression of multidrug resistance protein (MRP) and glutathione S-transferase P1-1 (GSTP1-1) in MCF7 cells and high level resistance to the cytotoxicities of ethacrynic acid but not oxazaphosphorines or cisplatin.	Ethacrynic Acid	168-183	glutathione S-transferase pi 1	Homo sapiens	94-101
9855012-3	1998	Glutathione tranferases (GSTs) have been demonstrated to catalyze the detoxification of DEs.	desacetyluvaricin	88-91	glutathione S-transferase pi 1	Homo sapiens	25-29
9855012-5	1998	Here we determined to which extent heterologously expressed human GSTP1-1, a major GST isoform in lung, affects the mutagenicity of stereoisomeric bay-region DEs of benzo[a]pyrene in Chinese hamster V79 cells.	Benzo(a)pyrene	165-179	glutathione S-transferase pi 1	Homo sapiens	66-73
9855012-10	1998	This study demonstrates that differences in the caalytic activity seen for purified GST towards individual mutagens do not necessarily reflect the detoxification of DEs by the same enzyme in a living cell and provides further evidence that specific human GSTs play a role in the detoxification of DEs of PAHs.	desacetyluvaricin	165-168	glutathione S-transferase pi 1	Homo sapiens	255-259
9855012-10	1998	This study demonstrates that differences in the caalytic activity seen for purified GST towards individual mutagens do not necessarily reflect the detoxification of DEs by the same enzyme in a living cell and provides further evidence that specific human GSTs play a role in the detoxification of DEs of PAHs.	desacetyluvaricin	297-300	glutathione S-transferase pi 1	Homo sapiens	255-259
9855012-10	1998	This study demonstrates that differences in the caalytic activity seen for purified GST towards individual mutagens do not necessarily reflect the detoxification of DEs by the same enzyme in a living cell and provides further evidence that specific human GSTs play a role in the detoxification of DEs of PAHs.	Polycyclic Aromatic Hydrocarbons	304-308	glutathione S-transferase pi 1	Homo sapiens	255-259
9827546-2	1998	This study reports the catalytic efficiencies (k(cat)/Km) of two naturally occurring variants, GSTP1-1/I-105 and GSTP1-1/ V-105, towards a series of fjord-region diol epoxides representing potent biologically active PAH metabolites, and two GSTP1-1 mutants with Ala105 and Trp105 in the active site.	diol epoxides	162-175	glutathione S-transferase pi 1	Homo sapiens	95-102
9827546-2	1998	This study reports the catalytic efficiencies (k(cat)/Km) of two naturally occurring variants, GSTP1-1/I-105 and GSTP1-1/ V-105, towards a series of fjord-region diol epoxides representing potent biologically active PAH metabolites, and two GSTP1-1 mutants with Ala105 and Trp105 in the active site.	diol epoxides	162-175	glutathione S-transferase pi 1	Homo sapiens	113-120
9827546-2	1998	This study reports the catalytic efficiencies (k(cat)/Km) of two naturally occurring variants, GSTP1-1/I-105 and GSTP1-1/ V-105, towards a series of fjord-region diol epoxides representing potent biologically active PAH metabolites, and two GSTP1-1 mutants with Ala105 and Trp105 in the active site.	diol epoxides	162-175	glutathione S-transferase pi 1	Homo sapiens	113-120
9827546-2	1998	This study reports the catalytic efficiencies (k(cat)/Km) of two naturally occurring variants, GSTP1-1/I-105 and GSTP1-1/ V-105, towards a series of fjord-region diol epoxides representing potent biologically active PAH metabolites, and two GSTP1-1 mutants with Ala105 and Trp105 in the active site.	Polycyclic Aromatic Hydrocarbons	216-219	glutathione S-transferase pi 1	Homo sapiens	95-102
9827546-2	1998	This study reports the catalytic efficiencies (k(cat)/Km) of two naturally occurring variants, GSTP1-1/I-105 and GSTP1-1/ V-105, towards a series of fjord-region diol epoxides representing potent biologically active PAH metabolites, and two GSTP1-1 mutants with Ala105 and Trp105 in the active site.	Polycyclic Aromatic Hydrocarbons	216-219	glutathione S-transferase pi 1	Homo sapiens	113-120
9827546-2	1998	This study reports the catalytic efficiencies (k(cat)/Km) of two naturally occurring variants, GSTP1-1/I-105 and GSTP1-1/ V-105, towards a series of fjord-region diol epoxides representing potent biologically active PAH metabolites, and two GSTP1-1 mutants with Ala105 and Trp105 in the active site.	Polycyclic Aromatic Hydrocarbons	216-219	glutathione S-transferase pi 1	Homo sapiens	113-120
9827546-3	1998	The results indicate that individuals who are homozygous for the allele encoding GSTP1-1/V-105 might be more susceptible to PAH carcinogenesis due to other reasons than a reduced capacity for detoxifying diol epoxides.	Polycyclic Aromatic Hydrocarbons	124-127	glutathione S-transferase pi 1	Homo sapiens	81-88
9827546-3	1998	The results indicate that individuals who are homozygous for the allele encoding GSTP1-1/V-105 might be more susceptible to PAH carcinogenesis due to other reasons than a reduced capacity for detoxifying diol epoxides.	diol epoxides	204-217	glutathione S-transferase pi 1	Homo sapiens	81-88
9776312-0	1998	Combined expression of multidrug resistance protein (MRP) and glutathione S-transferase P1-1 (GSTP1-1) in MCF7 cells and high level resistance to the cytotoxicities of ethacrynic acid but not oxazaphosphorines or cisplatin.	Cisplatin	213-222	glutathione S-transferase pi 1	Homo sapiens	94-101
9776312-1	1998	We tested the hypothesis that combined increased expression of human glutathione S-transferase P1-1 (GSTP1-1), an enzyme that catalyzes the conjugation with glutathione of several toxic electrophiles, and the glutathione-conjugate efflux pump, multidrug resistance protein (MRP), confers high level resistance to the cytotoxicities of anticancer and other drugs.	Glutathione	69-80	glutathione S-transferase pi 1	Homo sapiens	101-108
9776312-1	1998	We tested the hypothesis that combined increased expression of human glutathione S-transferase P1-1 (GSTP1-1), an enzyme that catalyzes the conjugation with glutathione of several toxic electrophiles, and the glutathione-conjugate efflux pump, multidrug resistance protein (MRP), confers high level resistance to the cytotoxicities of anticancer and other drugs.	Glutathione	157-168	glutathione S-transferase pi 1	Homo sapiens	101-108
9776312-4	1998	We found that either MRP or GSTP1-1 alone conferred significant resistance to ethacrynic acid cytotoxicity.	Ethacrynic Acid	78-93	glutathione S-transferase pi 1	Homo sapiens	28-35
9776312-5	1998	Moreover, combined expression of GSTP1-1 and MRP conferred a high level of resistance to ethacrynic acid that was greater than resistance conferred by either protein alone.	Ethacrynic Acid	89-104	glutathione S-transferase pi 1	Homo sapiens	33-40
9776312-9	1998	These results establish that coordinated expression of MRP and GSTP1-1 can confer high level resistance to the cytotoxicities of some drugs, including ethacrynic acid, but that such resistance is variable and does not apply to all toxic drugs that can potentially form glutathione conjugates in either spontaneous or GSTP1-1-catalyzed reactions.	Ethacrynic Acid	151-166	glutathione S-transferase pi 1	Homo sapiens	63-70
9776312-9	1998	These results establish that coordinated expression of MRP and GSTP1-1 can confer high level resistance to the cytotoxicities of some drugs, including ethacrynic acid, but that such resistance is variable and does not apply to all toxic drugs that can potentially form glutathione conjugates in either spontaneous or GSTP1-1-catalyzed reactions.	Glutathione	269-280	glutathione S-transferase pi 1	Homo sapiens	63-70
9771942-3	1998	All three variants of hGSTP1-1 were significantly more efficient than either hGSTA1-1 or hGSTM1-1 in GSH conjugation of (+)-anti-5-MeCDE.	Glutathione	101-104	glutathione S-transferase pi 1	Homo sapiens	22-30
9788613-4	1998	The GST activity, cellular GSH level, and/or ATP-dependent efflux of monoglutathionylthiotepa were modulated using ethacrynic acid, D,L-buthionine-S,R-sulfoximine, probenecid, and verapamil to understand the interplay between GSTs, glutathione conjugation, and efflux of glutathione conjugates in more detail.	Adenosine Triphosphate	45-48	glutathione S-transferase pi 1	Homo sapiens	226-230
9788613-4	1998	The GST activity, cellular GSH level, and/or ATP-dependent efflux of monoglutathionylthiotepa were modulated using ethacrynic acid, D,L-buthionine-S,R-sulfoximine, probenecid, and verapamil to understand the interplay between GSTs, glutathione conjugation, and efflux of glutathione conjugates in more detail.	Monoglutathionylthiotepa	69-93	glutathione S-transferase pi 1	Homo sapiens	226-230
9788613-4	1998	The GST activity, cellular GSH level, and/or ATP-dependent efflux of monoglutathionylthiotepa were modulated using ethacrynic acid, D,L-buthionine-S,R-sulfoximine, probenecid, and verapamil to understand the interplay between GSTs, glutathione conjugation, and efflux of glutathione conjugates in more detail.	Ethacrynic Acid	115-130	glutathione S-transferase pi 1	Homo sapiens	226-230
9788613-6	1998	Pretreatment of cells with ethacrynic acid resulted in decreased formation of monoglutathionylthiotepa as a result of inhibition of GST in the GST-P1-1 transfectant.	Ethacrynic Acid	27-42	glutathione S-transferase pi 1	Homo sapiens	143-151
9788613-6	1998	Pretreatment of cells with ethacrynic acid resulted in decreased formation of monoglutathionylthiotepa as a result of inhibition of GST in the GST-P1-1 transfectant.	Monoglutathionylthiotepa	78-102	glutathione S-transferase pi 1	Homo sapiens	143-151
9788613-10	1998	Only enhanced biotransformation and subsequent transport of the glutathione conjugate into the medium (which occurs with the GST-P1-1 transfectant) results in enhanced viability.	Glutathione	64-75	glutathione S-transferase pi 1	Homo sapiens	125-133
9788613-1	1998	In this study, the role of glutathione S-transferase (GST) P1-1, the cellular reduced glutathione (GSH) status, and ATP-dependent efflux pumps in the cellular glutathione-dependent biotransformation of thiotepa and transport of the main metabolite monoglutathionylthiotepa in relation to cytotoxicity was studied in control and GST-P1-1-transfected MCF-7 cell lines.	Glutathione	27-38	glutathione S-transferase pi 1	Homo sapiens	328-334
9788613-1	1998	In this study, the role of glutathione S-transferase (GST) P1-1, the cellular reduced glutathione (GSH) status, and ATP-dependent efflux pumps in the cellular glutathione-dependent biotransformation of thiotepa and transport of the main metabolite monoglutathionylthiotepa in relation to cytotoxicity was studied in control and GST-P1-1-transfected MCF-7 cell lines.	Glutathione	99-102	glutathione S-transferase pi 1	Homo sapiens	328-334
9788613-1	1998	In this study, the role of glutathione S-transferase (GST) P1-1, the cellular reduced glutathione (GSH) status, and ATP-dependent efflux pumps in the cellular glutathione-dependent biotransformation of thiotepa and transport of the main metabolite monoglutathionylthiotepa in relation to cytotoxicity was studied in control and GST-P1-1-transfected MCF-7 cell lines.	Adenosine Triphosphate	116-119	glutathione S-transferase pi 1	Homo sapiens	328-334
9788613-1	1998	In this study, the role of glutathione S-transferase (GST) P1-1, the cellular reduced glutathione (GSH) status, and ATP-dependent efflux pumps in the cellular glutathione-dependent biotransformation of thiotepa and transport of the main metabolite monoglutathionylthiotepa in relation to cytotoxicity was studied in control and GST-P1-1-transfected MCF-7 cell lines.	Thiotepa	202-210	glutathione S-transferase pi 1	Homo sapiens	27-63
9788613-1	1998	In this study, the role of glutathione S-transferase (GST) P1-1, the cellular reduced glutathione (GSH) status, and ATP-dependent efflux pumps in the cellular glutathione-dependent biotransformation of thiotepa and transport of the main metabolite monoglutathionylthiotepa in relation to cytotoxicity was studied in control and GST-P1-1-transfected MCF-7 cell lines.	Thiotepa	202-210	glutathione S-transferase pi 1	Homo sapiens	328-334
9788613-2	1998	It was demonstrated that an enhanced cellular level of GST-P1-1 leads to an enhanced formation of monoglutathionylthiotepa, which is transported out of the cell into the medium.	Monoglutathionylthiotepa	98-122	glutathione S-transferase pi 1	Homo sapiens	55-63
9788613-3	1998	Monoglutathionylthiotepa was able to reversibly inhibit the activity of purified GST-P1-1, but only at nonphysiological concentrations, indicating that feedback inhibition of GST by its metabolites is not a relevant process in vivo.	Monoglutathionylthiotepa	0-24	glutathione S-transferase pi 1	Homo sapiens	81-89
9771942-3	1998	All three variants of hGSTP1-1 were significantly more efficient than either hGSTA1-1 or hGSTM1-1 in GSH conjugation of (+)-anti-5-MeCDE.	(+)-anti-5-mecde	120-136	glutathione S-transferase pi 1	Homo sapiens	22-30
9800384-1	1998	The objective of this study was to analyze the effect of the GSTM1 and GSTP1 genotypes on urinary 1-hydroxypyrene, a biomarker for exposure to polycyclic aromatic hydrocarbon.	1-hydroxypyrene	98-113	glutathione S-transferase pi 1	Homo sapiens	71-76
9800384-1	1998	The objective of this study was to analyze the effect of the GSTM1 and GSTP1 genotypes on urinary 1-hydroxypyrene, a biomarker for exposure to polycyclic aromatic hydrocarbon.	Polycyclic Aromatic Hydrocarbons	143-174	glutathione S-transferase pi 1	Homo sapiens	71-76
9771942-4	1998	The catalytic efficiencies of hGSTP1-1 variants toward (+)-anti-5-MeCDE were in the order hGSTP1-1(I104,A113) > hGSTP1-1(V104,V113) > hGSTP1-1(V104,A113).	(+)-anti-5-mecde	55-71	glutathione S-transferase pi 1	Homo sapiens	30-38
9771942-4	1998	The catalytic efficiencies of hGSTP1-1 variants toward (+)-anti-5-MeCDE were in the order hGSTP1-1(I104,A113) > hGSTP1-1(V104,V113) > hGSTP1-1(V104,A113).	(+)-anti-5-mecde	55-71	glutathione S-transferase pi 1	Homo sapiens	90-109
9771942-4	1998	The catalytic efficiencies of hGSTP1-1 variants toward (+)-anti-5-MeCDE were in the order hGSTP1-1(I104,A113) > hGSTP1-1(V104,V113) > hGSTP1-1(V104,A113).	(+)-anti-5-mecde	55-71	glutathione S-transferase pi 1	Homo sapiens	30-36
9771942-4	1998	The catalytic efficiencies of hGSTP1-1 variants toward (+)-anti-5-MeCDE were in the order hGSTP1-1(I104,A113) > hGSTP1-1(V104,V113) > hGSTP1-1(V104,A113).	(+)-anti-5-mecde	55-71	glutathione S-transferase pi 1	Homo sapiens	90-96
9771942-7	1998	Even though the mechanism of the differences in the activities of hGSTP1-1 variants toward anti-5-MeCDE versus anti-BPDE remains to be elucidated, it seems that the molecular configuration of the diol epoxide is an important determinant of the activity of hGSTP1-1 isoforms toward polycyclic aromatic hydrocarbon diol epoxides.	1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene	96-103	glutathione S-transferase pi 1	Homo sapiens	66-74
9771942-7	1998	Even though the mechanism of the differences in the activities of hGSTP1-1 variants toward anti-5-MeCDE versus anti-BPDE remains to be elucidated, it seems that the molecular configuration of the diol epoxide is an important determinant of the activity of hGSTP1-1 isoforms toward polycyclic aromatic hydrocarbon diol epoxides.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	116-120	glutathione S-transferase pi 1	Homo sapiens	66-74
9771942-7	1998	Even though the mechanism of the differences in the activities of hGSTP1-1 variants toward anti-5-MeCDE versus anti-BPDE remains to be elucidated, it seems that the molecular configuration of the diol epoxide is an important determinant of the activity of hGSTP1-1 isoforms toward polycyclic aromatic hydrocarbon diol epoxides.	diol epoxide	196-208	glutathione S-transferase pi 1	Homo sapiens	66-74
9771942-7	1998	Even though the mechanism of the differences in the activities of hGSTP1-1 variants toward anti-5-MeCDE versus anti-BPDE remains to be elucidated, it seems that the molecular configuration of the diol epoxide is an important determinant of the activity of hGSTP1-1 isoforms toward polycyclic aromatic hydrocarbon diol epoxides.	diol epoxide	196-208	glutathione S-transferase pi 1	Homo sapiens	256-264
9771942-7	1998	Even though the mechanism of the differences in the activities of hGSTP1-1 variants toward anti-5-MeCDE versus anti-BPDE remains to be elucidated, it seems that the molecular configuration of the diol epoxide is an important determinant of the activity of hGSTP1-1 isoforms toward polycyclic aromatic hydrocarbon diol epoxides.	polycyclic aromatic hydrocarbon diol epoxides	281-326	glutathione S-transferase pi 1	Homo sapiens	66-74
9635537-4	1998	METHODS: GSTP1-1 levels were measured in EDTA plasma combined with ethylenediaminetetraacetic acid using a recently developed sensitive and specific sandwich enzyme-linked immunoadsorbent assay.	Edetic Acid	41-45	glutathione S-transferase pi 1	Homo sapiens	9-16
9687571-2	1998	The chemopreventive role of glutathione S-transferases (GSTs) in protecting against covalent modification of DNA and other cellular macromolecules by BPDE was modeled in human T47D and MCF-7 cell lines previously stably transfected with human GSTpi1 (hGSTP1).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	150-154	glutathione S-transferase pi 1	Homo sapiens	56-60
9687571-4	1998	Dose-response experiments indicated that the high level of expression of hGSTP1-1 in the T47Dpi cell line (4411 +/- 183 milliunits/mg of cytosolic protein, using 1-Cl-2,4-dinitrobenzene as substrate), resulted in 70-90% reduction in the covalent 3H-adduct formation in DNA or RNA isolated from the GSTP1-transfected T47Dpi cell line.	1-cl-2,4-dinitrobenzene	162-185	glutathione S-transferase pi 1	Homo sapiens	73-81
9687571-4	1998	Dose-response experiments indicated that the high level of expression of hGSTP1-1 in the T47Dpi cell line (4411 +/- 183 milliunits/mg of cytosolic protein, using 1-Cl-2,4-dinitrobenzene as substrate), resulted in 70-90% reduction in the covalent 3H-adduct formation in DNA or RNA isolated from the GSTP1-transfected T47Dpi cell line.	1-cl-2,4-dinitrobenzene	162-185	glutathione S-transferase pi 1	Homo sapiens	74-79
9687571-4	1998	Dose-response experiments indicated that the high level of expression of hGSTP1-1 in the T47Dpi cell line (4411 +/- 183 milliunits/mg of cytosolic protein, using 1-Cl-2,4-dinitrobenzene as substrate), resulted in 70-90% reduction in the covalent 3H-adduct formation in DNA or RNA isolated from the GSTP1-transfected T47Dpi cell line.	Tritium	246-248	glutathione S-transferase pi 1	Homo sapiens	73-81
9687571-4	1998	Dose-response experiments indicated that the high level of expression of hGSTP1-1 in the T47Dpi cell line (4411 +/- 183 milliunits/mg of cytosolic protein, using 1-Cl-2,4-dinitrobenzene as substrate), resulted in 70-90% reduction in the covalent 3H-adduct formation in DNA or RNA isolated from the GSTP1-transfected T47Dpi cell line.	Tritium	246-248	glutathione S-transferase pi 1	Homo sapiens	74-79
9687571-5	1998	The lower level of hGSTP1-1 expression in the transfected MCF-7 cell line (91 milliunits/mg) provided only marginal protection against [3H]BPDE adduct formation and did not affect sensitivity to BPDE-induced cytotoxicity.	3h]bpde	136-143	glutathione S-transferase pi 1	Homo sapiens	19-25
9687571-5	1998	The lower level of hGSTP1-1 expression in the transfected MCF-7 cell line (91 milliunits/mg) provided only marginal protection against [3H]BPDE adduct formation and did not affect sensitivity to BPDE-induced cytotoxicity.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	139-143	glutathione S-transferase pi 1	Homo sapiens	19-25
9687571-8	1998	These results indicate that hGSTP1-1 protects effectively against DNA and RNA modification by BPDE, but moderate to high level expression may be required for strong protection against BPDE-induced genotoxicity and cytotoxicity.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	94-98	glutathione S-transferase pi 1	Homo sapiens	28-36
9635580-2	1998	M7609 human colon carcinoma, selected for resistance to doxorubicin, and MCF-7 human breast carcinoma, selected for resistance to cyclophosphamide, both showed increased sensitivity to TER286 over their parental lines in parallel with increased expression of GST P1-1.	TER 286	185-191	glutathione S-transferase pi 1	Homo sapiens	259-267
9539246-7	1998	For GSTP1, the data were suggestive of a trend of increasing risk with higher numbers of codon 105 valine alleles (compared with isoleucine alleles); a 1.97-fold increased risk of breast cancer (95% CI = 0.77-5.02) was associated with valine/valine homozygosity.	Valine	99-105	glutathione S-transferase pi 1	Homo sapiens	4-9
9679562-5	1998	AS-ONs directed to the A-->G and C-->T transitions, unique to hGSTP1*C, were more RNAse H-dependent than AS-ONs directed against the translation initiation site, indicating a greater involvement of RNAse H-dependent mRNA cleavage in the mechanism of translational inhibition by AS-ON at the polymorphic site.	Arsenic	0-2	glutathione S-transferase pi 1	Homo sapiens	68-74
9679562-5	1998	AS-ONs directed to the A-->G and C-->T transitions, unique to hGSTP1*C, were more RNAse H-dependent than AS-ONs directed against the translation initiation site, indicating a greater involvement of RNAse H-dependent mRNA cleavage in the mechanism of translational inhibition by AS-ON at the polymorphic site.	as-on	0-5	glutathione S-transferase pi 1	Homo sapiens	68-74
9679569-1	1998	The authors have shown that expression of mGSTM1-1 or hGSTP1-1 in MCF-7 cells protects against DNA alkylation by 4-nitroquinoline-1-oxide (NQO) in an isozyme-specific manner and is commensurate with relative specific activity.	4-Nitroquinoline-1-oxide	113-137	glutathione S-transferase pi 1	Homo sapiens	54-62
9576856-4	1998	Two human class Pi (P) enzymes (GST P1-1 with Ile or Val at position 105) displayed no activity towards the phospholipid hydroperoxide.	Isoleucine	46-49	glutathione S-transferase pi 1	Homo sapiens	32-38
9576856-4	1998	Two human class Pi (P) enzymes (GST P1-1 with Ile or Val at position 105) displayed no activity towards the phospholipid hydroperoxide.	Valine	53-56	glutathione S-transferase pi 1	Homo sapiens	32-38
9679546-4	1998	Seven repeat retinoic acid response element (RARE) consensus half sites, A(G)GG(T)TC(G)A at +1521 to +1644 were identified in the cloned hGSTP1*C. Five of the RARE half-sites had the minimal spacer nucleotide requirement for functionality and DNA mobility shift analysis with different pairs of the RARE half-sites and supershift studies using antibodies against RAR-beta showed significant binding of nuclear protein complexes from RA-treated cells to these RAREs.	Tretinoin	13-26	glutathione S-transferase pi 1	Homo sapiens	137-143
9679546-4	1998	Seven repeat retinoic acid response element (RARE) consensus half sites, A(G)GG(T)TC(G)A at +1521 to +1644 were identified in the cloned hGSTP1*C. Five of the RARE half-sites had the minimal spacer nucleotide requirement for functionality and DNA mobility shift analysis with different pairs of the RARE half-sites and supershift studies using antibodies against RAR-beta showed significant binding of nuclear protein complexes from RA-treated cells to these RAREs.	Radium	45-47	glutathione S-transferase pi 1	Homo sapiens	137-143
9539246-7	1998	For GSTP1, the data were suggestive of a trend of increasing risk with higher numbers of codon 105 valine alleles (compared with isoleucine alleles); a 1.97-fold increased risk of breast cancer (95% CI = 0.77-5.02) was associated with valine/valine homozygosity.	Valine	235-241	glutathione S-transferase pi 1	Homo sapiens	4-9
9539246-7	1998	For GSTP1, the data were suggestive of a trend of increasing risk with higher numbers of codon 105 valine alleles (compared with isoleucine alleles); a 1.97-fold increased risk of breast cancer (95% CI = 0.77-5.02) was associated with valine/valine homozygosity.	Valine	235-241	glutathione S-transferase pi 1	Homo sapiens	4-9
9525277-1	1998	Previous studies have identified allelic variants of the human glutathione transferase (GST) Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) or valine (GSTP1-1/V-105) at position 105, respectively, differ significantly in their catalytic activities with model substrates.	Glutathione	63-74	glutathione S-transferase pi 1	Homo sapiens	169-176
9524203-7	1998	Moreover, partial demethylation of the GSTP1 CpG island by treatment with 5-aza-2"-deoxycytidine resulted in de novo gene expression in ER+ cell lines, as detected by RT-PCR, Northern blot and Western blot analyses.	Decitabine	74-96	glutathione S-transferase pi 1	Homo sapiens	39-44
9525277-1	1998	Previous studies have identified allelic variants of the human glutathione transferase (GST) Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) or valine (GSTP1-1/V-105) at position 105, respectively, differ significantly in their catalytic activities with model substrates.	Glutathione	63-74	glutathione S-transferase pi 1	Homo sapiens	195-202
9525277-11	1998	In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH.	diol epoxides	292-305	glutathione S-transferase pi 1	Homo sapiens	115-122
9525277-11	1998	In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH.	diol epoxides	292-305	glutathione S-transferase pi 1	Homo sapiens	242-249
9525277-11	1998	In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH.	Benzo(a)pyrene	309-323	glutathione S-transferase pi 1	Homo sapiens	94-99
9525277-11	1998	In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH.	Benzo(a)pyrene	309-323	glutathione S-transferase pi 1	Homo sapiens	115-122
9525277-11	1998	In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH.	Benzo(a)pyrene	309-323	glutathione S-transferase pi 1	Homo sapiens	242-249
9525277-11	1998	In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH.	Polycyclic Aromatic Hydrocarbons	348-351	glutathione S-transferase pi 1	Homo sapiens	94-99
9525277-11	1998	In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH.	Polycyclic Aromatic Hydrocarbons	348-351	glutathione S-transferase pi 1	Homo sapiens	115-122
9525277-11	1998	In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH.	Polycyclic Aromatic Hydrocarbons	348-351	glutathione S-transferase pi 1	Homo sapiens	242-249
9525277-1	1998	Previous studies have identified allelic variants of the human glutathione transferase (GST) Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) or valine (GSTP1-1/V-105) at position 105, respectively, differ significantly in their catalytic activities with model substrates.	Isoleucine	157-167	glutathione S-transferase pi 1	Homo sapiens	169-176
9525277-1	1998	Previous studies have identified allelic variants of the human glutathione transferase (GST) Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) or valine (GSTP1-1/V-105) at position 105, respectively, differ significantly in their catalytic activities with model substrates.	Valine	187-193	glutathione S-transferase pi 1	Homo sapiens	195-202
9525277-3	1998	In the present study the catalytic efficiencies (kcat/Km) of these GSTP1-1 variants were determined with a number of stereoisomeric bay-region diol epoxides, known as the ultimate mutagenic and carcinogenic metabolites of PAH, including those from chrysene, benzo[a]pyrene and dibenz[a,h]anthracene.	diol epoxides	143-156	glutathione S-transferase pi 1	Homo sapiens	67-74
9525277-3	1998	In the present study the catalytic efficiencies (kcat/Km) of these GSTP1-1 variants were determined with a number of stereoisomeric bay-region diol epoxides, known as the ultimate mutagenic and carcinogenic metabolites of PAH, including those from chrysene, benzo[a]pyrene and dibenz[a,h]anthracene.	Polycyclic Aromatic Hydrocarbons	222-225	glutathione S-transferase pi 1	Homo sapiens	67-74
9525277-3	1998	In the present study the catalytic efficiencies (kcat/Km) of these GSTP1-1 variants were determined with a number of stereoisomeric bay-region diol epoxides, known as the ultimate mutagenic and carcinogenic metabolites of PAH, including those from chrysene, benzo[a]pyrene and dibenz[a,h]anthracene.	chrysene	248-256	glutathione S-transferase pi 1	Homo sapiens	67-74
9525277-3	1998	In the present study the catalytic efficiencies (kcat/Km) of these GSTP1-1 variants were determined with a number of stereoisomeric bay-region diol epoxides, known as the ultimate mutagenic and carcinogenic metabolites of PAH, including those from chrysene, benzo[a]pyrene and dibenz[a,h]anthracene.	Benzo(a)pyrene	258-272	glutathione S-transferase pi 1	Homo sapiens	67-74
9525277-3	1998	In the present study the catalytic efficiencies (kcat/Km) of these GSTP1-1 variants were determined with a number of stereoisomeric bay-region diol epoxides, known as the ultimate mutagenic and carcinogenic metabolites of PAH, including those from chrysene, benzo[a]pyrene and dibenz[a,h]anthracene.	1,2,5,6-dibenzanthracene	277-298	glutathione S-transferase pi 1	Homo sapiens	67-74
9525277-4	1998	In addition, GSTP1-1 mutants in which amino residue 105 is alanine (GSTP1-1/A-105) or tryptophan (GSTP1-1/W-105) have been constructed and characterized.	amino	38-43	glutathione S-transferase pi 1	Homo sapiens	13-20
9525277-4	1998	In addition, GSTP1-1 mutants in which amino residue 105 is alanine (GSTP1-1/A-105) or tryptophan (GSTP1-1/W-105) have been constructed and characterized.	amino	38-43	glutathione S-transferase pi 1	Homo sapiens	68-75
9525277-4	1998	In addition, GSTP1-1 mutants in which amino residue 105 is alanine (GSTP1-1/A-105) or tryptophan (GSTP1-1/W-105) have been constructed and characterized.	amino	38-43	glutathione S-transferase pi 1	Homo sapiens	68-75
9525277-4	1998	In addition, GSTP1-1 mutants in which amino residue 105 is alanine (GSTP1-1/A-105) or tryptophan (GSTP1-1/W-105) have been constructed and characterized.	Alanine	59-66	glutathione S-transferase pi 1	Homo sapiens	13-20
9525277-4	1998	In addition, GSTP1-1 mutants in which amino residue 105 is alanine (GSTP1-1/A-105) or tryptophan (GSTP1-1/W-105) have been constructed and characterized.	Alanine	59-66	glutathione S-transferase pi 1	Homo sapiens	68-75
9525277-4	1998	In addition, GSTP1-1 mutants in which amino residue 105 is alanine (GSTP1-1/A-105) or tryptophan (GSTP1-1/W-105) have been constructed and characterized.	Alanine	59-66	glutathione S-transferase pi 1	Homo sapiens	68-75
9525277-4	1998	In addition, GSTP1-1 mutants in which amino residue 105 is alanine (GSTP1-1/A-105) or tryptophan (GSTP1-1/W-105) have been constructed and characterized.	Tryptophan	86-96	glutathione S-transferase pi 1	Homo sapiens	13-20
9525277-5	1998	GSTP1-1/V-105 was found to be more active than GSTP1-1/I-105 in conjugation reactions with the bulky diol epoxides of PAH, being up to 3-fold as active towards the anti- and syn-diol epoxide enantiomers with R-absolute configuration at the benzylic oxiranyl carbon.	diol epoxides	101-114	glutathione S-transferase pi 1	Homo sapiens	0-7
9525277-5	1998	GSTP1-1/V-105 was found to be more active than GSTP1-1/I-105 in conjugation reactions with the bulky diol epoxides of PAH, being up to 3-fold as active towards the anti- and syn-diol epoxide enantiomers with R-absolute configuration at the benzylic oxiranyl carbon.	diol epoxides	101-114	glutathione S-transferase pi 1	Homo sapiens	47-54
9525277-5	1998	GSTP1-1/V-105 was found to be more active than GSTP1-1/I-105 in conjugation reactions with the bulky diol epoxides of PAH, being up to 3-fold as active towards the anti- and syn-diol epoxide enantiomers with R-absolute configuration at the benzylic oxiranyl carbon.	Polycyclic Aromatic Hydrocarbons	118-121	glutathione S-transferase pi 1	Homo sapiens	0-7
9525277-5	1998	GSTP1-1/V-105 was found to be more active than GSTP1-1/I-105 in conjugation reactions with the bulky diol epoxides of PAH, being up to 3-fold as active towards the anti- and syn-diol epoxide enantiomers with R-absolute configuration at the benzylic oxiranyl carbon.	Polycyclic Aromatic Hydrocarbons	118-121	glutathione S-transferase pi 1	Homo sapiens	47-54
9525277-5	1998	GSTP1-1/V-105 was found to be more active than GSTP1-1/I-105 in conjugation reactions with the bulky diol epoxides of PAH, being up to 3-fold as active towards the anti- and syn-diol epoxide enantiomers with R-absolute configuration at the benzylic oxiranyl carbon.	diol epoxide	101-113	glutathione S-transferase pi 1	Homo sapiens	0-7
9525277-5	1998	GSTP1-1/V-105 was found to be more active than GSTP1-1/I-105 in conjugation reactions with the bulky diol epoxides of PAH, being up to 3-fold as active towards the anti- and syn-diol epoxide enantiomers with R-absolute configuration at the benzylic oxiranyl carbon.	diol epoxide	101-113	glutathione S-transferase pi 1	Homo sapiens	47-54
9525277-5	1998	GSTP1-1/V-105 was found to be more active than GSTP1-1/I-105 in conjugation reactions with the bulky diol epoxides of PAH, being up to 3-fold as active towards the anti- and syn-diol epoxide enantiomers with R-absolute configuration at the benzylic oxiranyl carbon.	Carbon	258-264	glutathione S-transferase pi 1	Homo sapiens	0-7
9525277-6	1998	Comparing the four enzyme variants, GSTP1-1/A-105 generally demonstrated the highest kcat/Km value and GSTP1-1/W-105 the lowest with the anti-diol epoxides.	Pregnanediol	142-146	glutathione S-transferase pi 1	Homo sapiens	36-43
9525277-6	1998	Comparing the four enzyme variants, GSTP1-1/A-105 generally demonstrated the highest kcat/Km value and GSTP1-1/W-105 the lowest with the anti-diol epoxides.	Pregnanediol	142-146	glutathione S-transferase pi 1	Homo sapiens	103-110
9525277-6	1998	Comparing the four enzyme variants, GSTP1-1/A-105 generally demonstrated the highest kcat/Km value and GSTP1-1/W-105 the lowest with the anti-diol epoxides.	Epoxy Compounds	147-155	glutathione S-transferase pi 1	Homo sapiens	36-43
9525277-6	1998	Comparing the four enzyme variants, GSTP1-1/A-105 generally demonstrated the highest kcat/Km value and GSTP1-1/W-105 the lowest with the anti-diol epoxides.	Epoxy Compounds	147-155	glutathione S-transferase pi 1	Homo sapiens	103-110
9525277-11	1998	In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH.	diol epoxides	292-305	glutathione S-transferase pi 1	Homo sapiens	94-99
9568063-1	1998	BACKGROUND: The aim of the present study was to establish the risk of squamous cell carcinoma (SCC) of the larynx associated with the congenital absence of glutathione S-transferase M1 (GSTM1), and to describe the expression of the isoenzymes GSTA1/2, GSTP1-1, and GSTM1 and glutathione (GSH) content in healthy and tumoral larynx tissue.	Glutathione	156-167	glutathione S-transferase pi 1	Homo sapiens	252-259
9546637-1	1998	Fatty acid ethyl ester synthase-III metabolizes both ethanol and carcinogens.	Ethanol	53-60	glutathione S-transferase pi 1	Homo sapiens	0-35
9299520-2	1997	The four possible isoforms of hGSTP1-1 with isoleucine or valine in position 104 and with alanine or valine in position 113 were produced by site-directed mutagenesis of the cDNA followed by bacterial expression and purification of the proteins.	Isoleucine	44-54	glutathione S-transferase pi 1	Homo sapiens	30-38
9472701-4	1998	This synergistic resistance to 4NQO toxicities (both nucleic acid adduct formation and cytotoxicity) is associated with a GSTP1-1-dependent increase in 4NQO-glutathione (QO-SG) conjugate formation and a MRP-dependent increase in QO-SG efflux.	4-Nitroquinoline-1-oxide	31-35	glutathione S-transferase pi 1	Homo sapiens	122-129
9472701-4	1998	This synergistic resistance to 4NQO toxicities (both nucleic acid adduct formation and cytotoxicity) is associated with a GSTP1-1-dependent increase in 4NQO-glutathione (QO-SG) conjugate formation and a MRP-dependent increase in QO-SG efflux.	4nqo-glutathione	152-168	glutathione S-transferase pi 1	Homo sapiens	122-129
9472701-6	1998	Moreover, this MRP-dependent efflux activity is necessary to achieve the full protection from 4NQO toxicity-protection that is potentiated by GSTP1-1-mediated QO-SG formation.	4-Nitroquinoline-1-oxide	94-98	glutathione S-transferase pi 1	Homo sapiens	142-149
9463521-1	1997	In the present study the irreversible inhibition of human glutathione S-transferase P1-1 (GSTP1-1) by alpha, beta-unsaturated aldehydes and ketones was studied.	alpha, beta-unsaturated aldehydes	102-135	glutathione S-transferase pi 1	Homo sapiens	90-97
9463521-1	1997	In the present study the irreversible inhibition of human glutathione S-transferase P1-1 (GSTP1-1) by alpha, beta-unsaturated aldehydes and ketones was studied.	Ketones	140-147	glutathione S-transferase pi 1	Homo sapiens	90-97
9463521-2	1997	When GSTP1-1 was incubated with a 50-fold molar excess of the aldehydes acrolein (ACR) and 4-hydroxy-2-nonenal (HNE) and the ketones curcumin (CUR) and ethacrynic acid (EA) at 22 degrees C, all of them inactivated GSTP1-1.	Aldehydes	62-71	glutathione S-transferase pi 1	Homo sapiens	5-12
9463521-2	1997	When GSTP1-1 was incubated with a 50-fold molar excess of the aldehydes acrolein (ACR) and 4-hydroxy-2-nonenal (HNE) and the ketones curcumin (CUR) and ethacrynic acid (EA) at 22 degrees C, all of them inactivated GSTP1-1.	Acrolein	82-85	glutathione S-transferase pi 1	Homo sapiens	5-12
9463521-2	1997	When GSTP1-1 was incubated with a 50-fold molar excess of the aldehydes acrolein (ACR) and 4-hydroxy-2-nonenal (HNE) and the ketones curcumin (CUR) and ethacrynic acid (EA) at 22 degrees C, all of them inactivated GSTP1-1.	4-hydroxy-2-nonenal	91-110	glutathione S-transferase pi 1	Homo sapiens	5-12
9463521-2	1997	When GSTP1-1 was incubated with a 50-fold molar excess of the aldehydes acrolein (ACR) and 4-hydroxy-2-nonenal (HNE) and the ketones curcumin (CUR) and ethacrynic acid (EA) at 22 degrees C, all of them inactivated GSTP1-1.	Ketones	125-132	glutathione S-transferase pi 1	Homo sapiens	5-12
9463521-2	1997	When GSTP1-1 was incubated with a 50-fold molar excess of the aldehydes acrolein (ACR) and 4-hydroxy-2-nonenal (HNE) and the ketones curcumin (CUR) and ethacrynic acid (EA) at 22 degrees C, all of them inactivated GSTP1-1.	Curcumin	133-141	glutathione S-transferase pi 1	Homo sapiens	5-12
9463521-2	1997	When GSTP1-1 was incubated with a 50-fold molar excess of the aldehydes acrolein (ACR) and 4-hydroxy-2-nonenal (HNE) and the ketones curcumin (CUR) and ethacrynic acid (EA) at 22 degrees C, all of them inactivated GSTP1-1.	Ethacrynic Acid	152-167	glutathione S-transferase pi 1	Homo sapiens	5-12
9463521-2	1997	When GSTP1-1 was incubated with a 50-fold molar excess of the aldehydes acrolein (ACR) and 4-hydroxy-2-nonenal (HNE) and the ketones curcumin (CUR) and ethacrynic acid (EA) at 22 degrees C, all of them inactivated GSTP1-1.	Ethacrynic Acid	169-171	glutathione S-transferase pi 1	Homo sapiens	5-12
9463521-4	1997	The aldehydes crotonaldehyde (CRA), cinnamaldehyde (CA) and trans-2-hexenal were found to inhibit GSTP1-1 only at a 5000-fold molar excess and even then, for example, for CA a higher remaining activity of 17% was observed.	2-butenal	30-33	glutathione S-transferase pi 1	Homo sapiens	98-105
9403173-6	1997	With GSTP1-1, the enzyme demonstrated appreciable activity toward both bay- and fjord-region diol epoxides and, in most cases, a preference for the anti-diastereomers.	diol epoxides	93-106	glutathione S-transferase pi 1	Homo sapiens	5-12
9403173-7	1997	In contrast to GSTM1-1 and as previously shown for GSTA1-1, GSTP1-1 showed an exclusive preference for conjugation of the enantiomers with R-configuration at the benzylic oxirane carbon.	benzylic oxirane	162-178	glutathione S-transferase pi 1	Homo sapiens	60-67
9403173-7	1997	In contrast to GSTM1-1 and as previously shown for GSTA1-1, GSTP1-1 showed an exclusive preference for conjugation of the enantiomers with R-configuration at the benzylic oxirane carbon.	Carbon	179-185	glutathione S-transferase pi 1	Homo sapiens	60-67
9403173-8	1997	With both GSTM1-1 and GSTP1-1, the chemically most reactive diol epoxide, the (+)-syn-enantiomer of trans-7,8-dihydroxy-9,10-epoxy-7,8,9,-10-tetrahydrobenzo[a]pyrene (BPDE), was the best substrate.	diol epoxide	60-72	glutathione S-transferase pi 1	Homo sapiens	22-29
9403173-8	1997	With both GSTM1-1 and GSTP1-1, the chemically most reactive diol epoxide, the (+)-syn-enantiomer of trans-7,8-dihydroxy-9,10-epoxy-7,8,9,-10-tetrahydrobenzo[a]pyrene (BPDE), was the best substrate.	trans-7,8-dihydroxy-9,10-epoxy-7,8,9,-10-tetrahydrobenzo[a]pyrene	100-165	glutathione S-transferase pi 1	Homo sapiens	22-29
9403173-10	1997	Molecular modeling of diol epoxides in the active sites of GSTP1-1 and -A1-1 is in agreement with the assumption, based on functional studies, that the H-site of GSTA1-1 [Jernstrom et al.	diol epoxides	22-35	glutathione S-transferase pi 1	Homo sapiens	59-66
9403173-12	1997	Further, modeling of the enantiomers of anti- and syn-BPDE in the active site of GSTP1-1 provides an explanation for the exclusive preference for the enantiomers with R-configuration at the benzylic oxirane carbon.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	54-58	glutathione S-transferase pi 1	Homo sapiens	81-88
9403173-12	1997	Further, modeling of the enantiomers of anti- and syn-BPDE in the active site of GSTP1-1 provides an explanation for the exclusive preference for the enantiomers with R-configuration at the benzylic oxirane carbon.	benzylic oxirane	190-206	glutathione S-transferase pi 1	Homo sapiens	81-88
9403173-12	1997	Further, modeling of the enantiomers of anti- and syn-BPDE in the active site of GSTP1-1 provides an explanation for the exclusive preference for the enantiomers with R-configuration at the benzylic oxirane carbon.	Carbon	207-213	glutathione S-transferase pi 1	Homo sapiens	81-88
10026993-13	1998	A polymorphic site of GSTP1 (valine to isoleucine at codon 104) decreases activity to several carcinogenic diol epoxides and was associated with testicular, bladder and lung cancer.	diol epoxides	107-120	glutathione S-transferase pi 1	Homo sapiens	22-27
9463521-4	1997	The aldehydes crotonaldehyde (CRA), cinnamaldehyde (CA) and trans-2-hexenal were found to inhibit GSTP1-1 only at a 5000-fold molar excess and even then, for example, for CA a higher remaining activity of 17% was observed.	cinnamaldehyde	36-50	glutathione S-transferase pi 1	Homo sapiens	98-105
9463521-4	1997	The aldehydes crotonaldehyde (CRA), cinnamaldehyde (CA) and trans-2-hexenal were found to inhibit GSTP1-1 only at a 5000-fold molar excess and even then, for example, for CA a higher remaining activity of 17% was observed.	2-hexenal	60-75	glutathione S-transferase pi 1	Homo sapiens	98-105
9463521-10	1997	When [14C]EA was incubated with the GSTP1-1, modified by the alpha, beta-unsaturated carbonyl compounds, no [14C]EA was incorporated in the enzyme, indicating that in all cases this cysteine residue was one of the major targets.	Carbon-14	6-9	glutathione S-transferase pi 1	Homo sapiens	36-43
9463521-10	1997	When [14C]EA was incubated with the GSTP1-1, modified by the alpha, beta-unsaturated carbonyl compounds, no [14C]EA was incorporated in the enzyme, indicating that in all cases this cysteine residue was one of the major targets.	alpha, beta-unsaturated carbonyl compounds	61-103	glutathione S-transferase pi 1	Homo sapiens	36-43
9463521-10	1997	When [14C]EA was incubated with the GSTP1-1, modified by the alpha, beta-unsaturated carbonyl compounds, no [14C]EA was incorporated in the enzyme, indicating that in all cases this cysteine residue was one of the major targets.	Carbon-14	109-112	glutathione S-transferase pi 1	Homo sapiens	36-43
9463521-10	1997	When [14C]EA was incubated with the GSTP1-1, modified by the alpha, beta-unsaturated carbonyl compounds, no [14C]EA was incorporated in the enzyme, indicating that in all cases this cysteine residue was one of the major targets.	Cysteine	182-190	glutathione S-transferase pi 1	Homo sapiens	36-43
9463521-13	1997	The results indicate that alpha, beta-unsaturated carbonyl derivatives inhibit GSTP1-1 irreversibly mainly by binding to cysteine residues of GSTP1-1, especially Cys-47, This means that some of these compounds (e.g. CUR) might modify GST activity in vivo when GSH concentrations are low by covalent binding to the enzyme.	alpha, beta-unsaturated carbonyl	26-58	glutathione S-transferase pi 1	Homo sapiens	79-86
9463521-13	1997	The results indicate that alpha, beta-unsaturated carbonyl derivatives inhibit GSTP1-1 irreversibly mainly by binding to cysteine residues of GSTP1-1, especially Cys-47, This means that some of these compounds (e.g. CUR) might modify GST activity in vivo when GSH concentrations are low by covalent binding to the enzyme.	alpha, beta-unsaturated carbonyl	26-58	glutathione S-transferase pi 1	Homo sapiens	142-149
9463521-13	1997	The results indicate that alpha, beta-unsaturated carbonyl derivatives inhibit GSTP1-1 irreversibly mainly by binding to cysteine residues of GSTP1-1, especially Cys-47, This means that some of these compounds (e.g. CUR) might modify GST activity in vivo when GSH concentrations are low by covalent binding to the enzyme.	Cysteine	121-129	glutathione S-transferase pi 1	Homo sapiens	79-86
9463521-13	1997	The results indicate that alpha, beta-unsaturated carbonyl derivatives inhibit GSTP1-1 irreversibly mainly by binding to cysteine residues of GSTP1-1, especially Cys-47, This means that some of these compounds (e.g. CUR) might modify GST activity in vivo when GSH concentrations are low by covalent binding to the enzyme.	Cysteine	121-129	glutathione S-transferase pi 1	Homo sapiens	142-149
9463521-13	1997	The results indicate that alpha, beta-unsaturated carbonyl derivatives inhibit GSTP1-1 irreversibly mainly by binding to cysteine residues of GSTP1-1, especially Cys-47, This means that some of these compounds (e.g. CUR) might modify GST activity in vivo when GSH concentrations are low by covalent binding to the enzyme.	Cysteine	162-165	glutathione S-transferase pi 1	Homo sapiens	79-86
9325266-2	1997	The second domain of cytosolic glutathione S-transferases (GSTs) contains a strictly conserved N-capping box motif (Ser/Thr-Xaa-Xaa-Asp) at the beginning of alpha6-helix in the hydrophobic core of the molecule.	Nitrogen	95-96	glutathione S-transferase pi 1	Homo sapiens	59-63
9325266-2	1997	The second domain of cytosolic glutathione S-transferases (GSTs) contains a strictly conserved N-capping box motif (Ser/Thr-Xaa-Xaa-Asp) at the beginning of alpha6-helix in the hydrophobic core of the molecule.	Serine	116-119	glutathione S-transferase pi 1	Homo sapiens	59-63
9325266-2	1997	The second domain of cytosolic glutathione S-transferases (GSTs) contains a strictly conserved N-capping box motif (Ser/Thr-Xaa-Xaa-Asp) at the beginning of alpha6-helix in the hydrophobic core of the molecule.	Threonine	120-123	glutathione S-transferase pi 1	Homo sapiens	59-63
9325266-2	1997	The second domain of cytosolic glutathione S-transferases (GSTs) contains a strictly conserved N-capping box motif (Ser/Thr-Xaa-Xaa-Asp) at the beginning of alpha6-helix in the hydrophobic core of the molecule.	Aspartic Acid	132-135	glutathione S-transferase pi 1	Homo sapiens	59-63
9299520-2	1997	The four possible isoforms of hGSTP1-1 with isoleucine or valine in position 104 and with alanine or valine in position 113 were produced by site-directed mutagenesis of the cDNA followed by bacterial expression and purification of the proteins.	Valine	58-64	glutathione S-transferase pi 1	Homo sapiens	30-38
9299520-2	1997	The four possible isoforms of hGSTP1-1 with isoleucine or valine in position 104 and with alanine or valine in position 113 were produced by site-directed mutagenesis of the cDNA followed by bacterial expression and purification of the proteins.	Alanine	90-97	glutathione S-transferase pi 1	Homo sapiens	30-38
9299520-2	1997	The four possible isoforms of hGSTP1-1 with isoleucine or valine in position 104 and with alanine or valine in position 113 were produced by site-directed mutagenesis of the cDNA followed by bacterial expression and purification of the proteins.	Valine	101-107	glutathione S-transferase pi 1	Homo sapiens	30-38
9299520-6	1997	It is proposed that amino acid 113 functions as part of a clamp that lines the mouth of the water channel leading to the active sites of the hGSTP1-1 dimer and controls the access to substrates.	Water	92-97	glutathione S-transferase pi 1	Homo sapiens	141-147
9299520-8	1997	The widely different activities of the allelic isoforms toward carcinogenic diol epoxides of polycyclic aromatic hydrocarbons may help to explain the correlation between cancer susceptibility and genotype at the hGSTP1 locus that has been found by others.	diol epoxides	76-89	glutathione S-transferase pi 1	Homo sapiens	212-218
9299520-8	1997	The widely different activities of the allelic isoforms toward carcinogenic diol epoxides of polycyclic aromatic hydrocarbons may help to explain the correlation between cancer susceptibility and genotype at the hGSTP1 locus that has been found by others.	Polycyclic Aromatic Hydrocarbons	93-125	glutathione S-transferase pi 1	Homo sapiens	212-218
9307186-5	1997	RESULTS: GSTP1-1 levels in serum samples from 10 healthy controls were significantly (P < 0.0001) higher than in corresponding ethylenediaminetetraacetic acid (EDTA) plasma and varied with the type of blood collection tube used.	Edetic Acid	130-161	glutathione S-transferase pi 1	Homo sapiens	9-16
9281308-7	1997	These studies revealed that the enantioselectivity of hGSTP1-1 for (+)-anti-CDE and the differential catalytic efficiencies of the V104 and I104 forms of hGSTP1-1 in the GSH conjugation of (+)-anti-CDE were due to the differences in the active-site architecture of the two proteins.	Glutathione	170-173	glutathione S-transferase pi 1	Homo sapiens	154-162
9281308-1	1997	The kinetics of the conjugation of glutathione (GSH) with anti-1, 2-dihydroxy-3,4-oxy-1,2,3,4-tetrahydrochrysene (anti-CDE), the activated form of the widespread environmental pollutant chrysene, catalyzed by two naturally occurring polymorphic forms of the pi class human GSH S-transferase (hGSTP1-1), has been investigated.	Glutathione	35-46	glutathione S-transferase pi 1	Homo sapiens	292-300
9281308-1	1997	The kinetics of the conjugation of glutathione (GSH) with anti-1, 2-dihydroxy-3,4-oxy-1,2,3,4-tetrahydrochrysene (anti-CDE), the activated form of the widespread environmental pollutant chrysene, catalyzed by two naturally occurring polymorphic forms of the pi class human GSH S-transferase (hGSTP1-1), has been investigated.	Glutathione	48-51	glutathione S-transferase pi 1	Homo sapiens	292-300
9281308-1	1997	The kinetics of the conjugation of glutathione (GSH) with anti-1, 2-dihydroxy-3,4-oxy-1,2,3,4-tetrahydrochrysene (anti-CDE), the activated form of the widespread environmental pollutant chrysene, catalyzed by two naturally occurring polymorphic forms of the pi class human GSH S-transferase (hGSTP1-1), has been investigated.	1, 2-dihydroxy-3,4-oxy-1,2,3,4-tetrahydrochrysene	63-112	glutathione S-transferase pi 1	Homo sapiens	292-300
9281308-2	1997	The polymorphic forms of hGSTP1-1, which differ in their primary structure by a single amino acid in position 104, exhibited preference for the GSH conjugation of (+)-anti-CDE, which is a far more potent carcinogen than (-)-anti-CDE.	Glutathione	144-147	glutathione S-transferase pi 1	Homo sapiens	25-33
9281308-3	1997	When concentration of anti-CDE was varied (5-200 microM and the GSH concentration was kept constant at 2 mM, both hGSTP1-1(I104) and hGSTP1-1(V104) obeyed Michaelis-Menten kinetics.	Glutathione	64-67	glutathione S-transferase pi 1	Homo sapiens	114-120
9281308-6	1997	The mechanism of the differences in the kinetic properties of hGSTP1-1 isoforms toward anti-CDE was investigated by molecular modeling of the two proteins with GSH conjugation products in their active sites.	Glutathione	160-163	glutathione S-transferase pi 1	Homo sapiens	62-68
9307186-5	1997	RESULTS: GSTP1-1 levels in serum samples from 10 healthy controls were significantly (P < 0.0001) higher than in corresponding ethylenediaminetetraacetic acid (EDTA) plasma and varied with the type of blood collection tube used.	Edetic Acid	163-167	glutathione S-transferase pi 1	Homo sapiens	9-16
9307186-6	1997	Refrigeration or delayed centrifugation of blood collected in plain EDTA tubes resulted in spuriously high plasma GSTP1-1 levels.	Edetic Acid	68-72	glutathione S-transferase pi 1	Homo sapiens	114-121
9245401-1	1997	Complex structures of a naturally occurring variant of human class pi glutathione S-transferase 1-1 (hGSTP1-1) with either S-hexylglutathione or (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9, 10-dihydrophenanthrene [(9R,10R)-GSPhen] have been determined at resolutions of 1.8 and 1.9 A, respectively.	(9r,10r)-9-(s-glutathionyl)-10-hydroxy-9, 10-dihydrophenanthrene	145-209	glutathione S-transferase pi 1	Homo sapiens	101-109
9245401-1	1997	Complex structures of a naturally occurring variant of human class pi glutathione S-transferase 1-1 (hGSTP1-1) with either S-hexylglutathione or (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9, 10-dihydrophenanthrene [(9R,10R)-GSPhen] have been determined at resolutions of 1.8 and 1.9 A, respectively.	hexylglutathione	123-141	glutathione S-transferase pi 1	Homo sapiens	101-109
9245401-1	1997	Complex structures of a naturally occurring variant of human class pi glutathione S-transferase 1-1 (hGSTP1-1) with either S-hexylglutathione or (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9, 10-dihydrophenanthrene [(9R,10R)-GSPhen] have been determined at resolutions of 1.8 and 1.9 A, respectively.	(9r,10r)-gsphen	211-226	glutathione S-transferase pi 1	Homo sapiens	101-109
9245401-4	1997	In hGSTP1-1, the cavity is approximately half hydrophobic and half hydrophilic and is defined by the side chains of Y7, F8, V10, R13, V104, Y108, N204, and G205 and five water molecules.	Water	170-175	glutathione S-transferase pi 1	Homo sapiens	3-11
9199210-1	1997	In this study, we demonstrate that the active site architecture of the human glutathione (GSH) S-transferase Pi (GSTP1-1) accounts for its enantioselectivity in the GSH conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9, 10-tetrahydrobenzo(a) pyrene (anti-BPDE), the ultimate carcinogen of benzo(a)pyrene.	Glutathione	77-88	glutathione S-transferase pi 1	Homo sapiens	113-120
9199210-1	1997	In this study, we demonstrate that the active site architecture of the human glutathione (GSH) S-transferase Pi (GSTP1-1) accounts for its enantioselectivity in the GSH conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9, 10-tetrahydrobenzo(a) pyrene (anti-BPDE), the ultimate carcinogen of benzo(a)pyrene.	Glutathione	90-93	glutathione S-transferase pi 1	Homo sapiens	113-120
9199210-1	1997	In this study, we demonstrate that the active site architecture of the human glutathione (GSH) S-transferase Pi (GSTP1-1) accounts for its enantioselectivity in the GSH conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9, 10-tetrahydrobenzo(a) pyrene (anti-BPDE), the ultimate carcinogen of benzo(a)pyrene.	Glutathione	165-168	glutathione S-transferase pi 1	Homo sapiens	113-120
9199210-1	1997	In this study, we demonstrate that the active site architecture of the human glutathione (GSH) S-transferase Pi (GSTP1-1) accounts for its enantioselectivity in the GSH conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9, 10-tetrahydrobenzo(a) pyrene (anti-BPDE), the ultimate carcinogen of benzo(a)pyrene.	7beta,8alpha-dihydroxy-9alpha	184-213	glutathione S-transferase pi 1	Homo sapiens	113-120
9199210-1	1997	In this study, we demonstrate that the active site architecture of the human glutathione (GSH) S-transferase Pi (GSTP1-1) accounts for its enantioselectivity in the GSH conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9, 10-tetrahydrobenzo(a) pyrene (anti-BPDE), the ultimate carcinogen of benzo(a)pyrene.	10alpha-oxy-7,8,9, 10-tetrahydrobenzo(a) pyrene	214-261	glutathione S-transferase pi 1	Homo sapiens	113-120
9199210-1	1997	In this study, we demonstrate that the active site architecture of the human glutathione (GSH) S-transferase Pi (GSTP1-1) accounts for its enantioselectivity in the GSH conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9, 10-tetrahydrobenzo(a) pyrene (anti-BPDE), the ultimate carcinogen of benzo(a)pyrene.	anti-	263-268	glutathione S-transferase pi 1	Homo sapiens	113-120
9199210-1	1997	In this study, we demonstrate that the active site architecture of the human glutathione (GSH) S-transferase Pi (GSTP1-1) accounts for its enantioselectivity in the GSH conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9, 10-tetrahydrobenzo(a) pyrene (anti-BPDE), the ultimate carcinogen of benzo(a)pyrene.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	268-272	glutathione S-transferase pi 1	Homo sapiens	113-120
9199210-1	1997	In this study, we demonstrate that the active site architecture of the human glutathione (GSH) S-transferase Pi (GSTP1-1) accounts for its enantioselectivity in the GSH conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9, 10-tetrahydrobenzo(a) pyrene (anti-BPDE), the ultimate carcinogen of benzo(a)pyrene.	Benzo(a)pyrene	302-316	glutathione S-transferase pi 1	Homo sapiens	113-120
9199210-2	1997	Furthermore, we report that the two polymorphic forms of human GSTP1-1, differing in their primary structure by a single amino acid in position 104, have disparate activity toward (+)-anti-BPDE, which can also be rationalized in terms of their active site structures.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	189-193	glutathione S-transferase pi 1	Homo sapiens	63-70
9199210-3	1997	When concentration of (+)-anti-BPDE, which among four BPDE isomers is the most potent carcinogen, was varied and GSH concentration was kept constant at 2 mM (saturating concentration), both forms of hGSTP1-1 [hGSTP1-1(V104) and hGSTP1-1(I104)] obeyed Michaelis-Menten kinetics.	(+)-anti-bpde	22-35	glutathione S-transferase pi 1	Homo sapiens	199-207
9199210-3	1997	When concentration of (+)-anti-BPDE, which among four BPDE isomers is the most potent carcinogen, was varied and GSH concentration was kept constant at 2 mM (saturating concentration), both forms of hGSTP1-1 [hGSTP1-1(V104) and hGSTP1-1(I104)] obeyed Michaelis-Menten kinetics.	(+)-anti-bpde	22-35	glutathione S-transferase pi 1	Homo sapiens	209-222
9199210-3	1997	When concentration of (+)-anti-BPDE, which among four BPDE isomers is the most potent carcinogen, was varied and GSH concentration was kept constant at 2 mM (saturating concentration), both forms of hGSTP1-1 [hGSTP1-1(V104) and hGSTP1-1(I104)] obeyed Michaelis-Menten kinetics.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	31-35	glutathione S-transferase pi 1	Homo sapiens	199-207
9199210-3	1997	When concentration of (+)-anti-BPDE, which among four BPDE isomers is the most potent carcinogen, was varied and GSH concentration was kept constant at 2 mM (saturating concentration), both forms of hGSTP1-1 [hGSTP1-1(V104) and hGSTP1-1(I104)] obeyed Michaelis-Menten kinetics.	Glutathione	113-116	glutathione S-transferase pi 1	Homo sapiens	199-207
9199210-4	1997	The V(max) of GSH conjugation of (+)-anti-BPDE was approximately 3.4-fold higher for hGSTP1-1(V104) than for hGSTP1-1(I104).	Glutathione	14-17	glutathione S-transferase pi 1	Homo sapiens	85-98
9199210-4	1997	The V(max) of GSH conjugation of (+)-anti-BPDE was approximately 3.4-fold higher for hGSTP1-1(V104) than for hGSTP1-1(I104).	Glutathione	14-17	glutathione S-transferase pi 1	Homo sapiens	109-122
9199210-4	1997	The V(max) of GSH conjugation of (+)-anti-BPDE was approximately 3.4-fold higher for hGSTP1-1(V104) than for hGSTP1-1(I104).	(+)-anti-	33-42	glutathione S-transferase pi 1	Homo sapiens	85-98
9199210-4	1997	The V(max) of GSH conjugation of (+)-anti-BPDE was approximately 3.4-fold higher for hGSTP1-1(V104) than for hGSTP1-1(I104).	(+)-anti-	33-42	glutathione S-transferase pi 1	Homo sapiens	109-122
9199210-4	1997	The V(max) of GSH conjugation of (+)-anti-BPDE was approximately 3.4-fold higher for hGSTP1-1(V104) than for hGSTP1-1(I104).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	42-46	glutathione S-transferase pi 1	Homo sapiens	85-98
9199210-4	1997	The V(max) of GSH conjugation of (+)-anti-BPDE was approximately 3.4-fold higher for hGSTP1-1(V104) than for hGSTP1-1(I104).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	42-46	glutathione S-transferase pi 1	Homo sapiens	109-122
9199210-8	1997	The mechanism of differences in kinetic properties and enantioselectivity of hGSTP1-1 variants toward anti-BPDE was investigated by modeling of the two proteins with conjugation product molecules in their active sites.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	107-111	glutathione S-transferase pi 1	Homo sapiens	77-85
9199210-9	1997	Molecular modeling studies revealed that the differences in catalytic properties of hGSTP1-1 variants as well as the enantioselectivity of hGSTP1-1 in the GSH conjugation of anti-BPDE can be rationalized in terms of the architecture of their active sites.	Glutathione	155-158	glutathione S-transferase pi 1	Homo sapiens	139-147
9199210-9	1997	Molecular modeling studies revealed that the differences in catalytic properties of hGSTP1-1 variants as well as the enantioselectivity of hGSTP1-1 in the GSH conjugation of anti-BPDE can be rationalized in terms of the architecture of their active sites.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	179-183	glutathione S-transferase pi 1	Homo sapiens	84-92
9199210-9	1997	Molecular modeling studies revealed that the differences in catalytic properties of hGSTP1-1 variants as well as the enantioselectivity of hGSTP1-1 in the GSH conjugation of anti-BPDE can be rationalized in terms of the architecture of their active sites.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	179-183	glutathione S-transferase pi 1	Homo sapiens	139-147
9199210-10	1997	Our results suggest that the population polymorphism of hGSTP1-1 variants with disparate enzyme activities may, at least in part, account for the differential susceptibility of individuals to carcinogens such as anti-BPDE and possibly other similar carcinogens.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	217-221	glutathione S-transferase pi 1	Homo sapiens	56-64
9164845-10	1997	Interestingly, experiments utilizing actinomycin D to inhibit transcription demonstrated significantly greater stability of GSTP1 mRNA in EJ cells than in VCREMS cells.	Dactinomycin	37-50	glutathione S-transferase pi 1	Homo sapiens	124-129
9184779-3	1997	Using the PCR to amplify a GSTP1 promoter sequence fragment containing 12 recognition sites for HpaII and MspI, 52 of 57 (91%) prostatic carcinoma DNA specimens demonstrated extensive somatic increases in deoxycytidine methylation, detected as amplification of target GSTP1 promoter sequences following HpaII digestion, but not following MspI treatment.	1-Methyl-S-(3-methylthiophosphoryl)imidazolium	106-110	glutathione S-transferase pi 1	Homo sapiens	27-32
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	69-72	glutathione S-transferase pi 1	Homo sapiens	52-58
9183003-1	1997	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST) P1-1 by calvatic acid and the reaction intermediates, i.e. the diazocyanide analogue of calvatic acid, has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different molar ratios of inhibitor/GST P1-1 indicate that 1 mol calvatic acid inactivates 1 mol GST P1-1, containing two catalytically equivalent active sites.	calvatic acid	93-106	glutathione S-transferase pi 1	Homo sapiens	80-87
9183003-1	1997	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST) P1-1 by calvatic acid and the reaction intermediates, i.e. the diazocyanide analogue of calvatic acid, has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different molar ratios of inhibitor/GST P1-1 indicate that 1 mol calvatic acid inactivates 1 mol GST P1-1, containing two catalytically equivalent active sites.	calvatic acid	93-106	glutathione S-transferase pi 1	Homo sapiens	301-309
9183003-1	1997	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST) P1-1 by calvatic acid and the reaction intermediates, i.e. the diazocyanide analogue of calvatic acid, has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different molar ratios of inhibitor/GST P1-1 indicate that 1 mol calvatic acid inactivates 1 mol GST P1-1, containing two catalytically equivalent active sites.	calvatic acid	93-106	glutathione S-transferase pi 1	Homo sapiens	362-370
9183003-1	1997	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST) P1-1 by calvatic acid and the reaction intermediates, i.e. the diazocyanide analogue of calvatic acid, has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different molar ratios of inhibitor/GST P1-1 indicate that 1 mol calvatic acid inactivates 1 mol GST P1-1, containing two catalytically equivalent active sites.	Diazocyanide	148-160	glutathione S-transferase pi 1	Homo sapiens	80-87
9183003-1	1997	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST) P1-1 by calvatic acid and the reaction intermediates, i.e. the diazocyanide analogue of calvatic acid, has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different molar ratios of inhibitor/GST P1-1 indicate that 1 mol calvatic acid inactivates 1 mol GST P1-1, containing two catalytically equivalent active sites.	calvatic acid	173-186	glutathione S-transferase pi 1	Homo sapiens	80-87
9183003-1	1997	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST) P1-1 by calvatic acid and the reaction intermediates, i.e. the diazocyanide analogue of calvatic acid, has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different molar ratios of inhibitor/GST P1-1 indicate that 1 mol calvatic acid inactivates 1 mol GST P1-1, containing two catalytically equivalent active sites.	calvatic acid	173-186	glutathione S-transferase pi 1	Homo sapiens	80-87
9183003-2	1997	However, 2 mol of the diazocyanide analogue of calvatic acid inactivate 1 mol GST P1-1.	Diazocyanide	22-34	glutathione S-transferase pi 1	Homo sapiens	78-86
9183003-2	1997	However, 2 mol of the diazocyanide analogue of calvatic acid inactivate 1 mol GST P1-1.	calvatic acid	47-60	glutathione S-transferase pi 1	Homo sapiens	78-86
9183003-3	1997	Two disulfide bridges/dimer, probably between Cys47 and Cys101, have been formed during the reaction of GST P1-1 with calvatic acid and its diazocyanide analogue.	Disulfides	4-13	glutathione S-transferase pi 1	Homo sapiens	104-110
9183003-3	1997	Two disulfide bridges/dimer, probably between Cys47 and Cys101, have been formed during the reaction of GST P1-1 with calvatic acid and its diazocyanide analogue.	calvatic acid	118-131	glutathione S-transferase pi 1	Homo sapiens	104-110
9183003-3	1997	Two disulfide bridges/dimer, probably between Cys47 and Cys101, have been formed during the reaction of GST P1-1 with calvatic acid and its diazocyanide analogue.	Diazocyanide	140-152	glutathione S-transferase pi 1	Homo sapiens	104-110
9183003-4	1997	The apparent second-order rate constants for GST P1-1 inactivation by calvatic acid and its diazocyanide analogue are 2.4+/-0.3 M(-1) s(-1) and (8.5+/-0.7) x 10(3) M(-1) s(-1), respectively.	calvatic acid	70-83	glutathione S-transferase pi 1	Homo sapiens	45-53
9183003-4	1997	The apparent second-order rate constants for GST P1-1 inactivation by calvatic acid and its diazocyanide analogue are 2.4+/-0.3 M(-1) s(-1) and (8.5+/-0.7) x 10(3) M(-1) s(-1), respectively.	Diazocyanide	92-104	glutathione S-transferase pi 1	Homo sapiens	45-53
21533477-5	1997	The GSTP1 cDNA transfectant KB/BSO3-pi established from KB/BSO3, and also HLE/BSO1-pi and HLE/BSO2-pi established from HLE/BSO1 and HLE/BSO2, restored cellular sensitivities to cisplatin and alkylating agents to similar levels as KB and HLE cells.	Cisplatin	177-186	glutathione S-transferase pi 1	Homo sapiens	4-9
21533477-6	1997	Our present results indicate that GSTP1 levels apparently limit cellular sensitivities to cisplatin and alkylating agents, suggesting that GSTP1 is a useful diagnostic marker for drug sensitivities to these agents in human cancer cells.	Cisplatin	90-99	glutathione S-transferase pi 1	Homo sapiens	34-39
21533477-6	1997	Our present results indicate that GSTP1 levels apparently limit cellular sensitivities to cisplatin and alkylating agents, suggesting that GSTP1 is a useful diagnostic marker for drug sensitivities to these agents in human cancer cells.	Cisplatin	90-99	glutathione S-transferase pi 1	Homo sapiens	139-144
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	69-72	glutathione S-transferase pi 1	Homo sapiens	77-83
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	69-72	glutathione S-transferase pi 1	Homo sapiens	77-83
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	69-72	glutathione S-transferase pi 1	Homo sapiens	77-83
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	gallocatechin gallate	126-129	glutathione S-transferase pi 1	Homo sapiens	52-58
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	gallocatechin gallate	126-129	glutathione S-transferase pi 1	Homo sapiens	77-83
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	gallocatechin gallate	126-129	glutathione S-transferase pi 1	Homo sapiens	77-83
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	gallocatechin gallate	126-129	glutathione S-transferase pi 1	Homo sapiens	77-83
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Alanine	131-134	glutathione S-transferase pi 1	Homo sapiens	52-58
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Alanine	131-134	glutathione S-transferase pi 1	Homo sapiens	77-83
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Alanine	131-134	glutathione S-transferase pi 1	Homo sapiens	77-83
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Alanine	131-134	glutathione S-transferase pi 1	Homo sapiens	77-83
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	144-147	glutathione S-transferase pi 1	Homo sapiens	52-58
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	144-147	glutathione S-transferase pi 1	Homo sapiens	77-83
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	144-147	glutathione S-transferase pi 1	Homo sapiens	77-83
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	144-147	glutathione S-transferase pi 1	Homo sapiens	77-83
9092542-6	1997	The encoded proteins expressed in Escherichia coli and purified by GSH affinity chromatography showed a 3-fold lower Km (CDNB) and a 3-4-fold higher Kcat/Km for the hGSTP1*A encoded protein than the proteins encoded by hGSTP1*B and hGSTP1*C. Analysis of 75 cases showed the relative frequency of hGSTP1*C to be 4-fold higher in malignant gliomas than in normal tissues.	Glutathione	67-70	glutathione S-transferase pi 1	Homo sapiens	165-171
9092542-6	1997	The encoded proteins expressed in Escherichia coli and purified by GSH affinity chromatography showed a 3-fold lower Km (CDNB) and a 3-4-fold higher Kcat/Km for the hGSTP1*A encoded protein than the proteins encoded by hGSTP1*B and hGSTP1*C. Analysis of 75 cases showed the relative frequency of hGSTP1*C to be 4-fold higher in malignant gliomas than in normal tissues.	Glutathione	67-70	glutathione S-transferase pi 1	Homo sapiens	219-225
9092542-6	1997	The encoded proteins expressed in Escherichia coli and purified by GSH affinity chromatography showed a 3-fold lower Km (CDNB) and a 3-4-fold higher Kcat/Km for the hGSTP1*A encoded protein than the proteins encoded by hGSTP1*B and hGSTP1*C. Analysis of 75 cases showed the relative frequency of hGSTP1*C to be 4-fold higher in malignant gliomas than in normal tissues.	Glutathione	67-70	glutathione S-transferase pi 1	Homo sapiens	219-225
9092542-6	1997	The encoded proteins expressed in Escherichia coli and purified by GSH affinity chromatography showed a 3-fold lower Km (CDNB) and a 3-4-fold higher Kcat/Km for the hGSTP1*A encoded protein than the proteins encoded by hGSTP1*B and hGSTP1*C. Analysis of 75 cases showed the relative frequency of hGSTP1*C to be 4-fold higher in malignant gliomas than in normal tissues.	Glutathione	67-70	glutathione S-transferase pi 1	Homo sapiens	219-225
9084911-3	1997	In the present study, the role of the major human GSTs in the conjugation of PGA2 and PGJ2 with GSH was investigated with purified enzymes, i.e., the Alpha-class enzymes GST A1-1 and GST A2-2, the Mu-class enzyme GST M1a-1a, and the Pi-class enzyme GST P1-1.	9-deoxy-delta-9-prostaglandin D2	86-90	glutathione S-transferase pi 1	Homo sapiens	249-257
9084911-3	1997	In the present study, the role of the major human GSTs in the conjugation of PGA2 and PGJ2 with GSH was investigated with purified enzymes, i.e., the Alpha-class enzymes GST A1-1 and GST A2-2, the Mu-class enzyme GST M1a-1a, and the Pi-class enzyme GST P1-1.	Glutathione	96-99	glutathione S-transferase pi 1	Homo sapiens	249-257
9084911-7	1997	Compared to the chemical reaction, enzyme activities towards PGA2 were up to 5.4 times as high (GSTA1-1) at the lowest concentration (70 microM), while at the highest concentration (600 microM) enzyme activities were up to 3.0 times as high (GST P1-1).	prostaglandin A2	61-65	glutathione S-transferase pi 1	Homo sapiens	242-250
8973647-4	1996	Structural differences appear to be prominent in domain 1 of oxidised GSTP1-1, in that the exposure of both tryptophan residues is increased, while the electric potential about one of them is altered.	Tryptophan	108-118	glutathione S-transferase pi 1	Homo sapiens	70-77
9084911-12	1997	GST P1-1 showed a clear selectivity with regard to the formation of the S-GSH conjugate of PGA2.	Glutathione	74-77	glutathione S-transferase pi 1	Homo sapiens	0-8
9084911-12	1997	GST P1-1 showed a clear selectivity with regard to the formation of the S-GSH conjugate of PGA2.	prostaglandin A2	91-95	glutathione S-transferase pi 1	Homo sapiens	0-8
9126875-8	1997	hGSTP 1-1 was not inhibited by Crystal Violet or by Ethyl Violet but was strongly inhibited by Malachite Green (Ki = 0.3 microM).	Gentian Violet	31-45	glutathione S-transferase pi 1	Homo sapiens	0-9
8955099-8	1996	The catalytic efficiency of GST 9.5 was approximately 4.5-fold higher than that of pi class human isoenzyme (hGSTP1-1), which among human GSTs is reported to be most efficient in the detoxification of (+)-anti-BPDE.	(+)-anti-bpde	201-214	glutathione S-transferase pi 1	Homo sapiens	109-117
9020891-1	1997	Although the three-dimensional structure of human glutathione transferase (GST) P1-1 crystallized with a GSH analogue has been reported, its structure in the non-complexed form has not been determined.	Glutathione	105-108	glutathione S-transferase pi 1	Homo sapiens	50-82
9020891-5	1997	When GST P1-1 and the antibody were incubated in the presence of 60 microM GSH, no inhibition of activity was found, whereas 1-chloro-2,4-dinitrobenzene had no effect at concentrations up to 10 microM.	Glutathione	75-78	glutathione S-transferase pi 1	Homo sapiens	5-13
9020891-6	1997	The binding of GST P1-1 to antibody adsorbed to Protein A-Sepharose was also prevented by both 0.1 mM GSH and N-ethylmaleimide treatment.	Sepharose	58-67	glutathione S-transferase pi 1	Homo sapiens	15-23
9020891-6	1997	The binding of GST P1-1 to antibody adsorbed to Protein A-Sepharose was also prevented by both 0.1 mM GSH and N-ethylmaleimide treatment.	Glutathione	102-105	glutathione S-transferase pi 1	Homo sapiens	15-23
9020891-6	1997	The binding of GST P1-1 to antibody adsorbed to Protein A-Sepharose was also prevented by both 0.1 mM GSH and N-ethylmaleimide treatment.	Ethylmaleimide	110-126	glutathione S-transferase pi 1	Homo sapiens	15-23
8973647-7	1996	The dithiothreitol-treated oxidised GSTP1-1 is able to regain its overall hydrodynamic volume; however, both its secondary-structural and tertiary-structural elements remain modified with respect to the native protein, as do both tryptophanyl environments.	Dithiothreitol	4-18	glutathione S-transferase pi 1	Homo sapiens	36-43
8886613-2	1996	We have characterized the busulfan-conjugating activity of purified human liver GSTA1-1, GSTA1-2, GSTA2-2, GSTM1-1, and placental GSTP1-1.	Busulfan	26-34	glutathione S-transferase pi 1	Homo sapiens	130-137
8950226-9	1996	Reversible inhibition of GST was the major mechanism of inhibition of DNPSG-excretion in melanoma cells, except in the cases of curcumin and ethacrynic acid, which compounds also inactivated GSTP1-1 by covalent modification.	Ethacrynic Acid	141-156	glutathione S-transferase pi 1	Homo sapiens	191-198
8678907-3	1996	Time-course inactivation of GSTP1-1 by two pesticides was prevented by 3 microM of hexyl-glutathione, but not by methylglutathione.	hexylglutathione	83-100	glutathione S-transferase pi 1	Homo sapiens	28-35
8678907-5	1996	That the inactivation of GSTP1-1 by captan and captafol involves the formation of disulfide bonds between the four cysteinil groups of the enzymes was confirmed by the SDS-PAGE experiments on nondenaturant conditions.	Captan	36-42	glutathione S-transferase pi 1	Homo sapiens	25-32
8678907-5	1996	That the inactivation of GSTP1-1 by captan and captafol involves the formation of disulfide bonds between the four cysteinil groups of the enzymes was confirmed by the SDS-PAGE experiments on nondenaturant conditions.	captafol	47-55	glutathione S-transferase pi 1	Homo sapiens	25-32
8678907-5	1996	That the inactivation of GSTP1-1 by captan and captafol involves the formation of disulfide bonds between the four cysteinil groups of the enzymes was confirmed by the SDS-PAGE experiments on nondenaturant conditions.	Disulfides	82-91	glutathione S-transferase pi 1	Homo sapiens	25-32
8678907-5	1996	That the inactivation of GSTP1-1 by captan and captafol involves the formation of disulfide bonds between the four cysteinil groups of the enzymes was confirmed by the SDS-PAGE experiments on nondenaturant conditions.	cysteinil	115-124	glutathione S-transferase pi 1	Homo sapiens	25-32
8678907-5	1996	That the inactivation of GSTP1-1 by captan and captafol involves the formation of disulfide bonds between the four cysteinil groups of the enzymes was confirmed by the SDS-PAGE experiments on nondenaturant conditions.	Sodium Dodecyl Sulfate	168-171	glutathione S-transferase pi 1	Homo sapiens	25-32
8678907-6	1996	In fact, on SDS-PAGE, GSTP1-1 as well as the cys47ala, cys101ala, and cys47ala/cys101ala GSTP1-1 mutants treated with captan and captafol showed several extra bands, with apparent molecular masses higher and lower than the molecular mass of native GSTP1-1 (23.5 kDa), indicating that both intra- and inter-subunit disulfide bonds were formed.	cys101ala	79-88	glutathione S-transferase pi 1	Homo sapiens	89-96
8678907-6	1996	In fact, on SDS-PAGE, GSTP1-1 as well as the cys47ala, cys101ala, and cys47ala/cys101ala GSTP1-1 mutants treated with captan and captafol showed several extra bands, with apparent molecular masses higher and lower than the molecular mass of native GSTP1-1 (23.5 kDa), indicating that both intra- and inter-subunit disulfide bonds were formed.	cys101ala	79-88	glutathione S-transferase pi 1	Homo sapiens	89-96
8678907-6	1996	In fact, on SDS-PAGE, GSTP1-1 as well as the cys47ala, cys101ala, and cys47ala/cys101ala GSTP1-1 mutants treated with captan and captafol showed several extra bands, with apparent molecular masses higher and lower than the molecular mass of native GSTP1-1 (23.5 kDa), indicating that both intra- and inter-subunit disulfide bonds were formed.	Captan	118-124	glutathione S-transferase pi 1	Homo sapiens	89-96
8678907-6	1996	In fact, on SDS-PAGE, GSTP1-1 as well as the cys47ala, cys101ala, and cys47ala/cys101ala GSTP1-1 mutants treated with captan and captafol showed several extra bands, with apparent molecular masses higher and lower than the molecular mass of native GSTP1-1 (23.5 kDa), indicating that both intra- and inter-subunit disulfide bonds were formed.	Captan	118-124	glutathione S-transferase pi 1	Homo sapiens	89-96
8678907-6	1996	In fact, on SDS-PAGE, GSTP1-1 as well as the cys47ala, cys101ala, and cys47ala/cys101ala GSTP1-1 mutants treated with captan and captafol showed several extra bands, with apparent molecular masses higher and lower than the molecular mass of native GSTP1-1 (23.5 kDa), indicating that both intra- and inter-subunit disulfide bonds were formed.	captafol	129-137	glutathione S-transferase pi 1	Homo sapiens	89-96
8678907-6	1996	In fact, on SDS-PAGE, GSTP1-1 as well as the cys47ala, cys101ala, and cys47ala/cys101ala GSTP1-1 mutants treated with captan and captafol showed several extra bands, with apparent molecular masses higher and lower than the molecular mass of native GSTP1-1 (23.5 kDa), indicating that both intra- and inter-subunit disulfide bonds were formed.	captafol	129-137	glutathione S-transferase pi 1	Homo sapiens	89-96
8678907-6	1996	In fact, on SDS-PAGE, GSTP1-1 as well as the cys47ala, cys101ala, and cys47ala/cys101ala GSTP1-1 mutants treated with captan and captafol showed several extra bands, with apparent molecular masses higher and lower than the molecular mass of native GSTP1-1 (23.5 kDa), indicating that both intra- and inter-subunit disulfide bonds were formed.	Disulfides	314-323	glutathione S-transferase pi 1	Homo sapiens	22-29
8546677-0	1996	The organization of the human GSTP1-1 gene promoter and its response to retinoic acid and cellular redox status.	Tretinoin	72-85	glutathione S-transferase pi 1	Homo sapiens	30-37
8620581-9	1996	Indications were found that human GST P1-1 may be inhibited via three mechanisms: in addition to the well documentated nucleophilic addition of quinones and oxidation of cysteine residues, a covalent subunit cross-linking was also observed.	Quinones	144-152	glutathione S-transferase pi 1	Homo sapiens	34-42
8620581-9	1996	Indications were found that human GST P1-1 may be inhibited via three mechanisms: in addition to the well documentated nucleophilic addition of quinones and oxidation of cysteine residues, a covalent subunit cross-linking was also observed.	Cysteine	170-178	glutathione S-transferase pi 1	Homo sapiens	34-42
9011239-4	1996	Statistically significant increasing in the concentration of fatty acids with C = 18 bound to GST P1-1 in tumour tissues, was demonstrated.	Fatty Acids	61-72	glutathione S-transferase pi 1	Homo sapiens	94-102
9011239-5	1996	The possibility of regulation of GST P1-1 activity, as well as the level of its phosphorylation on serine and threonine, under the influence of the epidermal growth factor, is shown.	Serine	99-105	glutathione S-transferase pi 1	Homo sapiens	33-41
8546677-3	1996	We have previously shown that the expression of GSTP1 is suppressed by retinoic acid (RA) in the presence of the retinoic acid receptor (RAR) as a result of decreased transcription from its promoter.	Tretinoin	71-84	glutathione S-transferase pi 1	Homo sapiens	48-53
8546677-3	1996	We have previously shown that the expression of GSTP1 is suppressed by retinoic acid (RA) in the presence of the retinoic acid receptor (RAR) as a result of decreased transcription from its promoter.	Tretinoin	86-88	glutathione S-transferase pi 1	Homo sapiens	48-53
8546677-15	1996	Interestingly, NAC is also an inducer for GSTP1.	Acetylcysteine	15-18	glutathione S-transferase pi 1	Homo sapiens	42-47
7728969-2	1995	GSTP1-1 showed a broad substrate specificity with both low and high GSH (10 mM) concentrations at pH 7.0, and the inhibitor insensitivity was then prominent.	Glutathione	68-71	glutathione S-transferase pi 1	Homo sapiens	0-7
8555414-11	1995	When 2 mM ifosfamide mustard was incubated with 1 mM GSH in the presence of 40 microM GST P1-1, the formation of monoglutathionyl ifosfamide mustard was 2.3-fold increased above the spontaneous level.	isophosphamide mustard	10-28	glutathione S-transferase pi 1	Homo sapiens	86-94
8555414-11	1995	When 2 mM ifosfamide mustard was incubated with 1 mM GSH in the presence of 40 microM GST P1-1, the formation of monoglutathionyl ifosfamide mustard was 2.3-fold increased above the spontaneous level.	Glutathione	53-56	glutathione S-transferase pi 1	Homo sapiens	86-94
8555414-11	1995	When 2 mM ifosfamide mustard was incubated with 1 mM GSH in the presence of 40 microM GST P1-1, the formation of monoglutathionyl ifosfamide mustard was 2.3-fold increased above the spontaneous level.	monoglutathionyl ifosfamide mustard	113-148	glutathione S-transferase pi 1	Homo sapiens	86-94
8555414-13	1995	The results of these studies demonstrate that increased levels of GST P1-1 can contribute to an enhanced detoxification of ifosfamide.	Ifosfamide	123-133	glutathione S-transferase pi 1	Homo sapiens	66-74
7712478-12	1995	At all pHs tested (range, 5.5-8.5), a marked catalytic effect of both GST P1-1 and A1-1 on the formation of monoglutathionyl conjugates was noted.	monoglutathionyl	108-124	glutathione S-transferase pi 1	Homo sapiens	70-87
7623066-6	1995	Total glutathione S-transferase (GST) and GST-p activities were similar in CPT-11-sensitive and -resistant cells.	Irinotecan	75-81	glutathione S-transferase pi 1	Homo sapiens	42-47
7864646-4	1995	In addition, the 34-kDa GSTP1-1 binds a number of hydrophobic compounds such as 1-chloro-2,4-dinitrobenzene, hemin, and bilirubin with the same affinity of the native enzyme.	Dinitrochlorobenzene	80-107	glutathione S-transferase pi 1	Homo sapiens	24-31
7864646-4	1995	In addition, the 34-kDa GSTP1-1 binds a number of hydrophobic compounds such as 1-chloro-2,4-dinitrobenzene, hemin, and bilirubin with the same affinity of the native enzyme.	Hemin	109-114	glutathione S-transferase pi 1	Homo sapiens	24-31
7864646-4	1995	In addition, the 34-kDa GSTP1-1 binds a number of hydrophobic compounds such as 1-chloro-2,4-dinitrobenzene, hemin, and bilirubin with the same affinity of the native enzyme.	Bilirubin	120-129	glutathione S-transferase pi 1	Homo sapiens	24-31
7887912-3	1995	GSTs A1-1, A2-2, M1a-1a and P1-1 catalysed both the forward and reverse reactions with specific activities (mumol/min per mg at 30 microM isothiocyanate or GSH conjugate) ranging from 23.1 for the GSH conjugation of BITC by GST P1-1 to 0.03 for the dissociation of BITC-SG by GST A1-1.	Glutathione	156-159	glutathione S-transferase pi 1	Homo sapiens	224-230
8020149-2	1994	While most anticancer agents are poor GST substrates, the model alkylating carcinogen 4-nitroquinoline-1-oxide (NQO) is a good substrate for human pi class GST (hGSTP1-1) and murine GST mu-1 (mGSTM1-1), but not human GST alpha-2 (hGSTA2-2).	4-Nitroquinoline-1-oxide	86-110	glutathione S-transferase pi 1	Homo sapiens	161-169
7972132-5	1994	Methylation of cytidine nucleotides in GSTP1 regulatory sequences constitutes the most common genomic alteration yet described for human prostate cancer.	cytidine nucleotides	15-35	glutathione S-transferase pi 1	Homo sapiens	39-44
7929235-9	1994	The Trp39-->Cys mutant was totally devoid of GST activity, while the activity of the Gln52-->Glu mutant was reduced to 6% of wild-type GSTP1-1.	Glutamic Acid	99-102	glutathione S-transferase pi 1	Homo sapiens	141-146
8020149-4	1994	Compared to parental MCF-7 or pSV2neotransfected control cell lines, covalent labeling of total cellular macromolecules by [3H]NQO (0.1-1.0 mM) was reduced by 70% and 92% in hGSTP1-1- and mGSTM1-1-transfected cell lines, respectively, but was not affected in the hGSTA2-2 expressing line.	3h]nqo	124-130	glutathione S-transferase pi 1	Homo sapiens	174-182
8185596-2	1994	Steady state kinetics measurements performed on human placenta glutathione transferase (GST P 1-1), utilizing 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) as co-substrate, show that the kcat value (approximately equal to 1.2 s-1) is pH-independent between pH 4.0 and 7.0 and is scarcely affected by the nature of the leaving group.	4-Chloro-7-nitrobenzofurazan	110-149	glutathione S-transferase pi 1	Homo sapiens	88-97
8185596-2	1994	Steady state kinetics measurements performed on human placenta glutathione transferase (GST P 1-1), utilizing 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) as co-substrate, show that the kcat value (approximately equal to 1.2 s-1) is pH-independent between pH 4.0 and 7.0 and is scarcely affected by the nature of the leaving group.	4-Chloro-7-nitrobenzofurazan	151-157	glutathione S-transferase pi 1	Homo sapiens	88-97
8069231-1	1994	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST P1-1) by the antibiotic p-carboxyphenylazoxycyanide (calvatic acid) has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different calvatic acid/GST P1-1 molar ratios indicate that one mole of calvatic acid inactivates one mole of the homodimeric enzyme molecule, containing two catalytically equivalent active sites.	Phosphorus	46-47	glutathione S-transferase pi 1	Homo sapiens	80-88
8069231-1	1994	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST P1-1) by the antibiotic p-carboxyphenylazoxycyanide (calvatic acid) has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different calvatic acid/GST P1-1 molar ratios indicate that one mole of calvatic acid inactivates one mole of the homodimeric enzyme molecule, containing two catalytically equivalent active sites.	Phosphorus	46-47	glutathione S-transferase pi 1	Homo sapiens	253-261
8069231-1	1994	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST P1-1) by the antibiotic p-carboxyphenylazoxycyanide (calvatic acid) has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different calvatic acid/GST P1-1 molar ratios indicate that one mole of calvatic acid inactivates one mole of the homodimeric enzyme molecule, containing two catalytically equivalent active sites.	carboxyphenylazoxycyanide	110-135	glutathione S-transferase pi 1	Homo sapiens	80-88
8069231-1	1994	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST P1-1) by the antibiotic p-carboxyphenylazoxycyanide (calvatic acid) has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different calvatic acid/GST P1-1 molar ratios indicate that one mole of calvatic acid inactivates one mole of the homodimeric enzyme molecule, containing two catalytically equivalent active sites.	calvatic acid	137-150	glutathione S-transferase pi 1	Homo sapiens	80-88
8069231-1	1994	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST P1-1) by the antibiotic p-carboxyphenylazoxycyanide (calvatic acid) has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different calvatic acid/GST P1-1 molar ratios indicate that one mole of calvatic acid inactivates one mole of the homodimeric enzyme molecule, containing two catalytically equivalent active sites.	calvatic acid	137-150	glutathione S-transferase pi 1	Homo sapiens	253-261
8069231-1	1994	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST P1-1) by the antibiotic p-carboxyphenylazoxycyanide (calvatic acid) has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different calvatic acid/GST P1-1 molar ratios indicate that one mole of calvatic acid inactivates one mole of the homodimeric enzyme molecule, containing two catalytically equivalent active sites.	calvatic acid	239-252	glutathione S-transferase pi 1	Homo sapiens	80-88
8069231-1	1994	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST P1-1) by the antibiotic p-carboxyphenylazoxycyanide (calvatic acid) has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different calvatic acid/GST P1-1 molar ratios indicate that one mole of calvatic acid inactivates one mole of the homodimeric enzyme molecule, containing two catalytically equivalent active sites.	calvatic acid	239-252	glutathione S-transferase pi 1	Homo sapiens	80-88
8069231-3	1994	The recovery of all the 5,5"-dithio-bis(2-nitro-benzoic acid)-titratable thiol groups as well as the original catalytic activity of GST P1-1 after treatment of the inhibited enzyme with dithiothreitol indicates that two disulfide bridges per dimer, likely between Cys47 and Cys101, have been formed during the reaction with calvatic acid.	Dithiothreitol	186-200	glutathione S-transferase pi 1	Homo sapiens	132-140
8069231-3	1994	The recovery of all the 5,5"-dithio-bis(2-nitro-benzoic acid)-titratable thiol groups as well as the original catalytic activity of GST P1-1 after treatment of the inhibited enzyme with dithiothreitol indicates that two disulfide bridges per dimer, likely between Cys47 and Cys101, have been formed during the reaction with calvatic acid.	Disulfides	220-229	glutathione S-transferase pi 1	Homo sapiens	132-140
8069231-3	1994	The recovery of all the 5,5"-dithio-bis(2-nitro-benzoic acid)-titratable thiol groups as well as the original catalytic activity of GST P1-1 after treatment of the inhibited enzyme with dithiothreitol indicates that two disulfide bridges per dimer, likely between Cys47 and Cys101, have been formed during the reaction with calvatic acid.	calvatic acid	324-337	glutathione S-transferase pi 1	Homo sapiens	132-140
8207617-1	1994	To investigate the possible role of glutathione S-transferase P (GSTP) in carcinogenesis and cell proliferation, ethacrynic acid (EA) was used to inhibit GSTP in the human Jurkat T cell line.	Ethacrynic Acid	113-128	glutathione S-transferase pi 1	Homo sapiens	36-63
8207617-1	1994	To investigate the possible role of glutathione S-transferase P (GSTP) in carcinogenesis and cell proliferation, ethacrynic acid (EA) was used to inhibit GSTP in the human Jurkat T cell line.	Ethacrynic Acid	113-128	glutathione S-transferase pi 1	Homo sapiens	154-158
8207617-1	1994	To investigate the possible role of glutathione S-transferase P (GSTP) in carcinogenesis and cell proliferation, ethacrynic acid (EA) was used to inhibit GSTP in the human Jurkat T cell line.	Ethacrynic Acid	130-132	glutathione S-transferase pi 1	Homo sapiens	154-158
8108434-3	1994	GST P1-1 was particularly active in catalyzing the reactions with the propenal derivatives, and adenine propenal was the substrate giving the highest activity.	Acrolein	70-78	glutathione S-transferase pi 1	Homo sapiens	0-8
8108434-3	1994	GST P1-1 was particularly active in catalyzing the reactions with the propenal derivatives, and adenine propenal was the substrate giving the highest activity.	9-(3-oxoprop-1-enyl)adenine	96-112	glutathione S-transferase pi 1	Homo sapiens	0-8
8108434-4	1994	The catalytic efficiency of GST P1-1 with adenine propenal (kcat/Km = 7.7 x 10(5) M-1.s-1) is the highest so far reported with any substrate for this enzyme.	9-(3-oxoprop-1-enyl)adenine	42-58	glutathione S-transferase pi 1	Homo sapiens	28-36
8108434-7	1994	At the cellular level, GST P1-1 was shown to provide protection against alpha, beta-unsaturated aldehydes.	alpha, beta-unsaturated aldehydes	72-105	glutathione S-transferase pi 1	Homo sapiens	23-31
8313381-1	1994	The reversibility of the conjugation reaction of the diuretic drug ethacrynic acid (EA), an alpha,beta-unsaturated ketone, with glutathione and glutathione S-transferase P1-1 (GST P1-1) has been studied.	Ethacrynic Acid	67-82	glutathione S-transferase pi 1	Homo sapiens	176-184
8108434-8	1994	GST P1-1 added to the culture medium of HeLa cells augmented the protective effect of glutathione against the toxicity of adenine propenal and thymine propenal.	Glutathione	86-97	glutathione S-transferase pi 1	Homo sapiens	0-8
8313381-1	1994	The reversibility of the conjugation reaction of the diuretic drug ethacrynic acid (EA), an alpha,beta-unsaturated ketone, with glutathione and glutathione S-transferase P1-1 (GST P1-1) has been studied.	Ethacrynic Acid	84-86	glutathione S-transferase pi 1	Homo sapiens	176-184
8108434-8	1994	GST P1-1 added to the culture medium of HeLa cells augmented the protective effect of glutathione against the toxicity of adenine propenal and thymine propenal.	9-(3-oxoprop-1-enyl)adenine	122-138	glutathione S-transferase pi 1	Homo sapiens	0-8
8108434-8	1994	GST P1-1 added to the culture medium of HeLa cells augmented the protective effect of glutathione against the toxicity of adenine propenal and thymine propenal.	3-(thymin-1'-yl)-2-propenal	143-159	glutathione S-transferase pi 1	Homo sapiens	0-8
8313381-1	1994	The reversibility of the conjugation reaction of the diuretic drug ethacrynic acid (EA), an alpha,beta-unsaturated ketone, with glutathione and glutathione S-transferase P1-1 (GST P1-1) has been studied.	alpha,beta-unsaturated ketone	92-121	glutathione S-transferase pi 1	Homo sapiens	176-184
8313381-2	1994	When the glutathione conjugate of EA was incubated with a 5-fold molar excess of N-acetyl-L-cysteine or GST P1-1, a time-dependent transfer of EA to N-acetyl-L-cysteine or GST P1-1 was observed.	Glutathione	9-20	glutathione S-transferase pi 1	Homo sapiens	104-112
8313381-2	1994	When the glutathione conjugate of EA was incubated with a 5-fold molar excess of N-acetyl-L-cysteine or GST P1-1, a time-dependent transfer of EA to N-acetyl-L-cysteine or GST P1-1 was observed.	Glutathione	9-20	glutathione S-transferase pi 1	Homo sapiens	172-180
8313381-2	1994	When the glutathione conjugate of EA was incubated with a 5-fold molar excess of N-acetyl-L-cysteine or GST P1-1, a time-dependent transfer of EA to N-acetyl-L-cysteine or GST P1-1 was observed.	Acetylcysteine	81-100	glutathione S-transferase pi 1	Homo sapiens	172-180
8313381-2	1994	When the glutathione conjugate of EA was incubated with a 5-fold molar excess of N-acetyl-L-cysteine or GST P1-1, a time-dependent transfer of EA to N-acetyl-L-cysteine or GST P1-1 was observed.	Ethacrynic Acid	34-36	glutathione S-transferase pi 1	Homo sapiens	104-112
8313381-2	1994	When the glutathione conjugate of EA was incubated with a 5-fold molar excess of N-acetyl-L-cysteine or GST P1-1, a time-dependent transfer of EA to N-acetyl-L-cysteine or GST P1-1 was observed.	Ethacrynic Acid	34-36	glutathione S-transferase pi 1	Homo sapiens	172-180
8313381-2	1994	When the glutathione conjugate of EA was incubated with a 5-fold molar excess of N-acetyl-L-cysteine or GST P1-1, a time-dependent transfer of EA to N-acetyl-L-cysteine or GST P1-1 was observed.	Acetylcysteine	149-168	glutathione S-transferase pi 1	Homo sapiens	104-112
8313381-4	1994	From the fact that preincubation of GST P1-1 with 1-chloro-2,4-dinitrobenzene reduced the incorporation of [14C]EA from 0.94 +/- 0.21 (SD) to 0.16 +/- 0.02 mol EA/mol subunit and from automated Edman degradation of the major radioactive peptide isolated after pepsin digestion of the [14C]EA-labeled enzyme, it was concluded that the reaction of EA takes place with cysteine 47 of GST P1-1.	Dinitrochlorobenzene	50-77	glutathione S-transferase pi 1	Homo sapiens	36-44
8313381-4	1994	From the fact that preincubation of GST P1-1 with 1-chloro-2,4-dinitrobenzene reduced the incorporation of [14C]EA from 0.94 +/- 0.21 (SD) to 0.16 +/- 0.02 mol EA/mol subunit and from automated Edman degradation of the major radioactive peptide isolated after pepsin digestion of the [14C]EA-labeled enzyme, it was concluded that the reaction of EA takes place with cysteine 47 of GST P1-1.	Dinitrochlorobenzene	50-77	glutathione S-transferase pi 1	Homo sapiens	381-389
8313381-4	1994	From the fact that preincubation of GST P1-1 with 1-chloro-2,4-dinitrobenzene reduced the incorporation of [14C]EA from 0.94 +/- 0.21 (SD) to 0.16 +/- 0.02 mol EA/mol subunit and from automated Edman degradation of the major radioactive peptide isolated after pepsin digestion of the [14C]EA-labeled enzyme, it was concluded that the reaction of EA takes place with cysteine 47 of GST P1-1.	Carbon-14	108-111	glutathione S-transferase pi 1	Homo sapiens	36-44
8313381-4	1994	From the fact that preincubation of GST P1-1 with 1-chloro-2,4-dinitrobenzene reduced the incorporation of [14C]EA from 0.94 +/- 0.21 (SD) to 0.16 +/- 0.02 mol EA/mol subunit and from automated Edman degradation of the major radioactive peptide isolated after pepsin digestion of the [14C]EA-labeled enzyme, it was concluded that the reaction of EA takes place with cysteine 47 of GST P1-1.	Carbon-14	285-288	glutathione S-transferase pi 1	Homo sapiens	36-44
8313381-4	1994	From the fact that preincubation of GST P1-1 with 1-chloro-2,4-dinitrobenzene reduced the incorporation of [14C]EA from 0.94 +/- 0.21 (SD) to 0.16 +/- 0.02 mol EA/mol subunit and from automated Edman degradation of the major radioactive peptide isolated after pepsin digestion of the [14C]EA-labeled enzyme, it was concluded that the reaction of EA takes place with cysteine 47 of GST P1-1.	Cysteine	366-374	glutathione S-transferase pi 1	Homo sapiens	36-44
8108434-10	1994	GST P1-1 introduced into Hep G2 cells by electroporation was similarly found to increase their resistance to acrolein.	Acrolein	109-117	glutathione S-transferase pi 1	Homo sapiens	0-8
8313381-5	1994	When GST P1-1 was inactivated with a 5-fold molar excess of EA, adding an excess of glutathione resulted in full restoration of the catalytic activity in about 120 h. These findings may have several implications.	Glutathione	84-95	glutathione S-transferase pi 1	Homo sapiens	5-13
8313381-6	1994	Under normal physiological conditions the inhibition of GST P1-1 by covalent binding of EA would be reversed by glutathione, leaving reversible inhibition by the glutathione conjugate of EA and by EA itself as the main mechanism of inhibition; however, when glutathione levels are low the covalent inhibition might be predominant, resulting in a completely different time course for the inhibition.	Glutathione	112-123	glutathione S-transferase pi 1	Homo sapiens	56-64
8340390-8	1993	The recombinant FAEES-III protein does not bind to a glutathione agarose affinity matrix, presumably because two of the substituted amino acids, Trp-39-->Cys and Gln-52-->Glu, are thought to contribute to the GST glutathione binding site.	Tryptophan	145-148	glutathione S-transferase pi 1	Homo sapiens	16-25
8313381-6	1994	Under normal physiological conditions the inhibition of GST P1-1 by covalent binding of EA would be reversed by glutathione, leaving reversible inhibition by the glutathione conjugate of EA and by EA itself as the main mechanism of inhibition; however, when glutathione levels are low the covalent inhibition might be predominant, resulting in a completely different time course for the inhibition.	Glutathione	162-173	glutathione S-transferase pi 1	Homo sapiens	56-64
8313381-6	1994	Under normal physiological conditions the inhibition of GST P1-1 by covalent binding of EA would be reversed by glutathione, leaving reversible inhibition by the glutathione conjugate of EA and by EA itself as the main mechanism of inhibition; however, when glutathione levels are low the covalent inhibition might be predominant, resulting in a completely different time course for the inhibition.	Glutathione	162-173	glutathione S-transferase pi 1	Homo sapiens	56-64
7857716-1	1994	Class pi-glutathione S-transferase (GSTP-1) is one of several factors proposed to affect drug sensitivity to cisdiamminedichloroplatinum (II) (CDDP).	Cisplatin	109-136	glutathione S-transferase pi 1	Homo sapiens	36-42
7857716-1	1994	Class pi-glutathione S-transferase (GSTP-1) is one of several factors proposed to affect drug sensitivity to cisdiamminedichloroplatinum (II) (CDDP).	Cisplatin	143-147	glutathione S-transferase pi 1	Homo sapiens	36-42
8242859-1	1993	We have expressed human glutathione S-transferases GSTA1-1 and GSTP1-1 in Salmonella typhimurium TA100 in order to assess the ability of these enzymes to modulate the mutagenicity of 1,2-dibromo-3-chloropropane (DBCP) and tris(2,3-dibromopropyl)phosphate (Tris-BP).	1,2-dibromo-3-chloropropane	183-210	glutathione S-transferase pi 1	Homo sapiens	63-70
8242859-1	1993	We have expressed human glutathione S-transferases GSTA1-1 and GSTP1-1 in Salmonella typhimurium TA100 in order to assess the ability of these enzymes to modulate the mutagenicity of 1,2-dibromo-3-chloropropane (DBCP) and tris(2,3-dibromopropyl)phosphate (Tris-BP).	1,2-dibromo-3-chloropropane	212-216	glutathione S-transferase pi 1	Homo sapiens	63-70
8242859-1	1993	We have expressed human glutathione S-transferases GSTA1-1 and GSTP1-1 in Salmonella typhimurium TA100 in order to assess the ability of these enzymes to modulate the mutagenicity of 1,2-dibromo-3-chloropropane (DBCP) and tris(2,3-dibromopropyl)phosphate (Tris-BP).	tris(2,3-dibromopropyl)phosphate	222-226	glutathione S-transferase pi 1	Homo sapiens	63-70
8242859-1	1993	We have expressed human glutathione S-transferases GSTA1-1 and GSTP1-1 in Salmonella typhimurium TA100 in order to assess the ability of these enzymes to modulate the mutagenicity of 1,2-dibromo-3-chloropropane (DBCP) and tris(2,3-dibromopropyl)phosphate (Tris-BP).	2,3-dibromopropylphosphate	227-254	glutathione S-transferase pi 1	Homo sapiens	63-70
8242859-1	1993	We have expressed human glutathione S-transferases GSTA1-1 and GSTP1-1 in Salmonella typhimurium TA100 in order to assess the ability of these enzymes to modulate the mutagenicity of 1,2-dibromo-3-chloropropane (DBCP) and tris(2,3-dibromopropyl)phosphate (Tris-BP).	tris(2,3-dibromopropyl)phosphate	256-263	glutathione S-transferase pi 1	Homo sapiens	63-70
8242859-6	1993	In the case of Tris-BP, GSTP1-1 was much more active in potentiating the mutagenicity.	tris(2,3-dibromopropyl)phosphate	15-22	glutathione S-transferase pi 1	Homo sapiens	24-31
8352805-1	1993	The pH-Vmax/KmGSH plot of glutathione S-transferase P (GST-P) showed a bell-shaped profile, indicating bifunctional catalysis for glutathione (GSH) conjugation.	Glutathione	26-37	glutathione S-transferase pi 1	Homo sapiens	55-60
8352805-1	1993	The pH-Vmax/KmGSH plot of glutathione S-transferase P (GST-P) showed a bell-shaped profile, indicating bifunctional catalysis for glutathione (GSH) conjugation.	Glutathione	14-17	glutathione S-transferase pi 1	Homo sapiens	26-53
8352805-1	1993	The pH-Vmax/KmGSH plot of glutathione S-transferase P (GST-P) showed a bell-shaped profile, indicating bifunctional catalysis for glutathione (GSH) conjugation.	Glutathione	14-17	glutathione S-transferase pi 1	Homo sapiens	55-60
8131222-9	1994	GST P1-1 is also the only isoenzyme susceptible to irreversible inhibition by 5-GSDA (33% inhibition), while no significant inhibition was observed with 5-GSMDOPA.	5-S-glutathionyldopamine	78-84	glutathione S-transferase pi 1	Homo sapiens	0-8
8131222-11	1994	This suggests that GST P1-1 is inhibited by disulfide formation in the case of 5-GSDA, while this oxidative pathway also substantially contributes to the inactivation by dopamine.	Disulfides	44-53	glutathione S-transferase pi 1	Homo sapiens	19-27
8131222-11	1994	This suggests that GST P1-1 is inhibited by disulfide formation in the case of 5-GSDA, while this oxidative pathway also substantially contributes to the inactivation by dopamine.	5-S-glutathionyldopamine	79-85	glutathione S-transferase pi 1	Homo sapiens	19-27
8131222-11	1994	This suggests that GST P1-1 is inhibited by disulfide formation in the case of 5-GSDA, while this oxidative pathway also substantially contributes to the inactivation by dopamine.	Dopamine	170-178	glutathione S-transferase pi 1	Homo sapiens	19-27
8131222-12	1994	This was supported by the HPLC-profile of the GST P1-1 subunit which was strongly affected by dopamine, while for 5-GSDA after reduction with dithiotreitol the original elution profile of the subunit returned.	Dopamine	94-102	glutathione S-transferase pi 1	Homo sapiens	46-54
8395980-7	1993	Studies with purified human GST A1-1, GST M1-1, GST M3-3, and GST P1-1 demonstrated that GST M3-3, but not the other isoenzymes, catalyzed the denitrosation of BCNU.	Carmustine	160-164	glutathione S-transferase pi 1	Homo sapiens	62-70
8364903-13	1993	Almost all GST-P+ foci identifiable in H&E stained sections were larger than ten cells, consisted of clear cells (in both groups) or mixed (clear-eosinophilic) cells in PB-exposed rats, and appeared to be evenly distributed throughout the three zones of the liver.	Adenosine Monophosphate	41-44	glutathione S-transferase pi 1	Homo sapiens	11-16
8364903-13	1993	Almost all GST-P+ foci identifiable in H&E stained sections were larger than ten cells, consisted of clear cells (in both groups) or mixed (clear-eosinophilic) cells in PB-exposed rats, and appeared to be evenly distributed throughout the three zones of the liver.	Phenobarbital	173-175	glutathione S-transferase pi 1	Homo sapiens	11-16
8343114-1	1993	Reaction of human GSH transferase P1-1 (GSTP1-1) with diethylpyrocarbonate (DEPC) at pH 7.0 and 4 degrees C resulted in covalent modification of an equivalent of one histidine and one tyrosine residue per subunit, with loss of activity.	Diethyl Pyrocarbonate	54-74	glutathione S-transferase pi 1	Homo sapiens	40-47
8343114-1	1993	Reaction of human GSH transferase P1-1 (GSTP1-1) with diethylpyrocarbonate (DEPC) at pH 7.0 and 4 degrees C resulted in covalent modification of an equivalent of one histidine and one tyrosine residue per subunit, with loss of activity.	Diethyl Pyrocarbonate	76-80	glutathione S-transferase pi 1	Homo sapiens	40-47
8343114-1	1993	Reaction of human GSH transferase P1-1 (GSTP1-1) with diethylpyrocarbonate (DEPC) at pH 7.0 and 4 degrees C resulted in covalent modification of an equivalent of one histidine and one tyrosine residue per subunit, with loss of activity.	Histidine	166-175	glutathione S-transferase pi 1	Homo sapiens	40-47
8343114-1	1993	Reaction of human GSH transferase P1-1 (GSTP1-1) with diethylpyrocarbonate (DEPC) at pH 7.0 and 4 degrees C resulted in covalent modification of an equivalent of one histidine and one tyrosine residue per subunit, with loss of activity.	Tyrosine	184-192	glutathione S-transferase pi 1	Homo sapiens	40-47
8343114-6	1993	Kinetic analysis of the DEPC modification of Tyr-7 in GSTP1-1 gave a k2 approx.	Tyrosine	45-48	glutathione S-transferase pi 1	Homo sapiens	54-61
8343114-8	1993	The reaction of Tyr-7 of GSTP1-1 with DEPC was poorly inhibited by 1 mM GSH (14%) or 10 microM S-hexylglutathione (18%).	Tyrosine	16-19	glutathione S-transferase pi 1	Homo sapiens	25-32
8343114-8	1993	The reaction of Tyr-7 of GSTP1-1 with DEPC was poorly inhibited by 1 mM GSH (14%) or 10 microM S-hexylglutathione (18%).	Glutathione	72-75	glutathione S-transferase pi 1	Homo sapiens	25-32
8343114-8	1993	The reaction of Tyr-7 of GSTP1-1 with DEPC was poorly inhibited by 1 mM GSH (14%) or 10 microM S-hexylglutathione (18%).	hexylglutathione	95-113	glutathione S-transferase pi 1	Homo sapiens	25-32
8343115-2	1993	Kinetic experiments demonstrated that inactivation of GSTP1-1 occurred upon reaction of one arginine residue per subunit with diacetyl, one lysine residue per subunit with 2,4,6-trinitrobenzene sulphonate, or one carboxylate group per subunit with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.	Arginine	92-100	glutathione S-transferase pi 1	Homo sapiens	54-61
8343115-2	1993	Kinetic experiments demonstrated that inactivation of GSTP1-1 occurred upon reaction of one arginine residue per subunit with diacetyl, one lysine residue per subunit with 2,4,6-trinitrobenzene sulphonate, or one carboxylate group per subunit with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.	Lysine	140-146	glutathione S-transferase pi 1	Homo sapiens	54-61
8343115-2	1993	Kinetic experiments demonstrated that inactivation of GSTP1-1 occurred upon reaction of one arginine residue per subunit with diacetyl, one lysine residue per subunit with 2,4,6-trinitrobenzene sulphonate, or one carboxylate group per subunit with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.	2,4,6-Trinitrobenzene Sulfonate	172-204	glutathione S-transferase pi 1	Homo sapiens	54-61
8343115-2	1993	Kinetic experiments demonstrated that inactivation of GSTP1-1 occurred upon reaction of one arginine residue per subunit with diacetyl, one lysine residue per subunit with 2,4,6-trinitrobenzene sulphonate, or one carboxylate group per subunit with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.	carboxylate	213-224	glutathione S-transferase pi 1	Homo sapiens	54-61
8343115-2	1993	Kinetic experiments demonstrated that inactivation of GSTP1-1 occurred upon reaction of one arginine residue per subunit with diacetyl, one lysine residue per subunit with 2,4,6-trinitrobenzene sulphonate, or one carboxylate group per subunit with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.	Ethyldimethylaminopropyl Carbodiimide	248-293	glutathione S-transferase pi 1	Homo sapiens	54-61
8343115-11	1993	The GSH-binding determinants of GSTP1-1 are compared using sequence similarity with those of GSTs of Alpha, Mu and Theta classes.	Glutathione	4-7	glutathione S-transferase pi 1	Homo sapiens	32-39
8343115-11	1993	The GSH-binding determinants of GSTP1-1 are compared using sequence similarity with those of GSTs of Alpha, Mu and Theta classes.	Glutathione	4-7	glutathione S-transferase pi 1	Homo sapiens	93-97
8340390-8	1993	The recombinant FAEES-III protein does not bind to a glutathione agarose affinity matrix, presumably because two of the substituted amino acids, Trp-39-->Cys and Gln-52-->Glu, are thought to contribute to the GST glutathione binding site.	Cysteine	157-160	glutathione S-transferase pi 1	Homo sapiens	16-25
8340390-8	1993	The recombinant FAEES-III protein does not bind to a glutathione agarose affinity matrix, presumably because two of the substituted amino acids, Trp-39-->Cys and Gln-52-->Glu, are thought to contribute to the GST glutathione binding site.	Glutamine	165-168	glutathione S-transferase pi 1	Homo sapiens	16-25
8340390-8	1993	The recombinant FAEES-III protein does not bind to a glutathione agarose affinity matrix, presumably because two of the substituted amino acids, Trp-39-->Cys and Gln-52-->Glu, are thought to contribute to the GST glutathione binding site.	Glutamic Acid	177-180	glutathione S-transferase pi 1	Homo sapiens	16-25
8340390-8	1993	The recombinant FAEES-III protein does not bind to a glutathione agarose affinity matrix, presumably because two of the substituted amino acids, Trp-39-->Cys and Gln-52-->Glu, are thought to contribute to the GST glutathione binding site.	Glutathione	219-230	glutathione S-transferase pi 1	Homo sapiens	16-25
8330352-8	1993	The mutagenicity of aflatoxin B1 (AFB1) was marginally decreased in strains expressing GSTP1-1.	Aflatoxin B1	20-32	glutathione S-transferase pi 1	Homo sapiens	87-94
8330357-11	1993	When the peak of DNA methylation produced by NMBzA in the perivenous cells coincided with a peak of cell division in that region, an increased number of GST-P+ hepatocytes was induced.	nitrosobenzylmethylamine	45-50	glutathione S-transferase pi 1	Homo sapiens	153-158
8391258-2	1993	It is shown that the expression of human glutathione S-transferase P1-1 (GSTP1-1) is suppressed by retinoic acid (RA) as the result of decreased transcription from its gene, GSTP1.	Tretinoin	114-116	glutathione S-transferase pi 1	Homo sapiens	73-78
8391258-2	1993	It is shown that the expression of human glutathione S-transferase P1-1 (GSTP1-1) is suppressed by retinoic acid (RA) as the result of decreased transcription from its gene, GSTP1.	Tretinoin	99-112	glutathione S-transferase pi 1	Homo sapiens	73-80
8391258-3	1993	Chloramphenicol acetyltransferase (CAT) assays indicate that the effect of RA on the transcription of a GSTP1 promoter-CAT fusion gene is mediated by the region -99 to +72 of GSTP1.	Tretinoin	75-77	glutathione S-transferase pi 1	Homo sapiens	104-109
8391258-2	1993	It is shown that the expression of human glutathione S-transferase P1-1 (GSTP1-1) is suppressed by retinoic acid (RA) as the result of decreased transcription from its gene, GSTP1.	Tretinoin	99-112	glutathione S-transferase pi 1	Homo sapiens	73-78
8391258-3	1993	Chloramphenicol acetyltransferase (CAT) assays indicate that the effect of RA on the transcription of a GSTP1 promoter-CAT fusion gene is mediated by the region -99 to +72 of GSTP1.	Tretinoin	75-77	glutathione S-transferase pi 1	Homo sapiens	175-180
8391258-2	1993	It is shown that the expression of human glutathione S-transferase P1-1 (GSTP1-1) is suppressed by retinoic acid (RA) as the result of decreased transcription from its gene, GSTP1.	Tretinoin	114-116	glutathione S-transferase pi 1	Homo sapiens	73-80
8391258-4	1993	A consensus activator protein 1-binding site, located at nucleotide position -59 to -65 of GSTP1, is suggested to be responsible for RA repression.	Tretinoin	133-135	glutathione S-transferase pi 1	Homo sapiens	91-96
8391258-5	1993	This effect of RA on GSTP1 expression is mediated by the human beta-type RA receptor, hRAR beta, but not the chicken retinoid X receptor, cRXR.	Tretinoin	15-17	glutathione S-transferase pi 1	Homo sapiens	21-26
8442764-6	1993	Protection of GST P1-1 against inhibition by ethacrynic acid by the substrate analog S-hexylglutathione, indicates an active site-directed modification.	Ethacrynic Acid	45-60	glutathione S-transferase pi 1	Homo sapiens	14-22
8470890-4	1993	On the other hand, there existed another hydrophobic ligand-binding region in GST-P, to which 1-amino-8-naphthalenesulfonic acid and bilirubin would bind with relatively lower affinity than the endogenously bound fatty acid.	peri Acid	94-128	glutathione S-transferase pi 1	Homo sapiens	78-83
8470890-4	1993	On the other hand, there existed another hydrophobic ligand-binding region in GST-P, to which 1-amino-8-naphthalenesulfonic acid and bilirubin would bind with relatively lower affinity than the endogenously bound fatty acid.	Bilirubin	133-142	glutathione S-transferase pi 1	Homo sapiens	78-83
8470890-4	1993	On the other hand, there existed another hydrophobic ligand-binding region in GST-P, to which 1-amino-8-naphthalenesulfonic acid and bilirubin would bind with relatively lower affinity than the endogenously bound fatty acid.	Fatty Acids	213-223	glutathione S-transferase pi 1	Homo sapiens	78-83
8470890-7	1993	In addition, the hydrophobic ligand binding caused a significant fluorescence quenching of tryptophan 38, which was assumed to be located at the active center of GST-P.	Tryptophan	91-101	glutathione S-transferase pi 1	Homo sapiens	162-167
8439332-0	1993	Identification of the fatty acid binding site on glutathione S-transferase P by immobilization to fatty acid-linked sepharose.	Fatty Acids	22-32	glutathione S-transferase pi 1	Homo sapiens	49-76
8439332-0	1993	Identification of the fatty acid binding site on glutathione S-transferase P by immobilization to fatty acid-linked sepharose.	Fatty Acids	98-108	glutathione S-transferase pi 1	Homo sapiens	49-76
8439332-0	1993	Identification of the fatty acid binding site on glutathione S-transferase P by immobilization to fatty acid-linked sepharose.	Sepharose	116-125	glutathione S-transferase pi 1	Homo sapiens	49-76
8439332-1	1993	The association of glutathione S-transferase P (GST-P) with various fatty acids was confirmed by gas-liquid chromatography and mass-spectrometry.	Fatty Acids	68-79	glutathione S-transferase pi 1	Homo sapiens	19-46
8439332-1	1993	The association of glutathione S-transferase P (GST-P) with various fatty acids was confirmed by gas-liquid chromatography and mass-spectrometry.	Fatty Acids	68-79	glutathione S-transferase pi 1	Homo sapiens	48-53
8439332-2	1993	Palmitic and stearic acids were the major fatty acids bound to the enzyme in which the molar ratio was 1:0.8 (GST-P:fatty acid).	Stearic Acids	13-26	glutathione S-transferase pi 1	Homo sapiens	110-115
8439332-2	1993	Palmitic and stearic acids were the major fatty acids bound to the enzyme in which the molar ratio was 1:0.8 (GST-P:fatty acid).	Fatty Acids	42-53	glutathione S-transferase pi 1	Homo sapiens	110-115
8439332-2	1993	Palmitic and stearic acids were the major fatty acids bound to the enzyme in which the molar ratio was 1:0.8 (GST-P:fatty acid).	Fatty Acids	42-52	glutathione S-transferase pi 1	Homo sapiens	110-115
8439332-4	1993	GST-P tightly bound the fatty acid-linked Sepharoses (CH3(CH2)nCOOH, n = 4 approximately 16), and the site was determined to be residues 121-156 from the amino terminus by tryptic digestion of GST-P bound to a fatty acid-linked Sepharose.	Fatty Acids	24-34	glutathione S-transferase pi 1	Homo sapiens	0-5
8439332-4	1993	GST-P tightly bound the fatty acid-linked Sepharoses (CH3(CH2)nCOOH, n = 4 approximately 16), and the site was determined to be residues 121-156 from the amino terminus by tryptic digestion of GST-P bound to a fatty acid-linked Sepharose.	Fatty Acids	24-34	glutathione S-transferase pi 1	Homo sapiens	193-198
8439332-4	1993	GST-P tightly bound the fatty acid-linked Sepharoses (CH3(CH2)nCOOH, n = 4 approximately 16), and the site was determined to be residues 121-156 from the amino terminus by tryptic digestion of GST-P bound to a fatty acid-linked Sepharose.	Sepharose	42-52	glutathione S-transferase pi 1	Homo sapiens	0-5
8439332-4	1993	GST-P tightly bound the fatty acid-linked Sepharoses (CH3(CH2)nCOOH, n = 4 approximately 16), and the site was determined to be residues 121-156 from the amino terminus by tryptic digestion of GST-P bound to a fatty acid-linked Sepharose.	Sepharose	42-52	glutathione S-transferase pi 1	Homo sapiens	193-198
8439332-4	1993	GST-P tightly bound the fatty acid-linked Sepharoses (CH3(CH2)nCOOH, n = 4 approximately 16), and the site was determined to be residues 121-156 from the amino terminus by tryptic digestion of GST-P bound to a fatty acid-linked Sepharose.	Fatty Acids	210-220	glutathione S-transferase pi 1	Homo sapiens	0-5
8439332-4	1993	GST-P tightly bound the fatty acid-linked Sepharoses (CH3(CH2)nCOOH, n = 4 approximately 16), and the site was determined to be residues 121-156 from the amino terminus by tryptic digestion of GST-P bound to a fatty acid-linked Sepharose.	Fatty Acids	210-220	glutathione S-transferase pi 1	Homo sapiens	193-198
8439332-4	1993	GST-P tightly bound the fatty acid-linked Sepharoses (CH3(CH2)nCOOH, n = 4 approximately 16), and the site was determined to be residues 121-156 from the amino terminus by tryptic digestion of GST-P bound to a fatty acid-linked Sepharose.	Sepharose	42-51	glutathione S-transferase pi 1	Homo sapiens	0-5
8439332-4	1993	GST-P tightly bound the fatty acid-linked Sepharoses (CH3(CH2)nCOOH, n = 4 approximately 16), and the site was determined to be residues 121-156 from the amino terminus by tryptic digestion of GST-P bound to a fatty acid-linked Sepharose.	Sepharose	42-51	glutathione S-transferase pi 1	Homo sapiens	193-198
8442764-6	1993	Protection of GST P1-1 against inhibition by ethacrynic acid by the substrate analog S-hexylglutathione, indicates an active site-directed modification.	hexylglutathione	85-103	glutathione S-transferase pi 1	Homo sapiens	14-22
8444404-2	1993	Fatty acid analysis by gas-liquid chromatography-mass spectrometry (GC-MS) revealed that GST-P forms 1:1 complex with fatty acids, mostly palmitic acid or stearic acid, which were hardly isolated from the complex even through Lipidex 1,000 column chromatography at 37 degrees C. Temperature dependent analysis of 1H-NMR on the association between GST-P and fatty acids indicated that molecular motion of fatty acids were strongly restrained in a hydrophobic "pocket" below the temperature of protein denaturation.	Fatty Acids	0-10	glutathione S-transferase pi 1	Homo sapiens	89-94
8444404-2	1993	Fatty acid analysis by gas-liquid chromatography-mass spectrometry (GC-MS) revealed that GST-P forms 1:1 complex with fatty acids, mostly palmitic acid or stearic acid, which were hardly isolated from the complex even through Lipidex 1,000 column chromatography at 37 degrees C. Temperature dependent analysis of 1H-NMR on the association between GST-P and fatty acids indicated that molecular motion of fatty acids were strongly restrained in a hydrophobic "pocket" below the temperature of protein denaturation.	lipidex	226-233	glutathione S-transferase pi 1	Homo sapiens	89-94
8444404-2	1993	Fatty acid analysis by gas-liquid chromatography-mass spectrometry (GC-MS) revealed that GST-P forms 1:1 complex with fatty acids, mostly palmitic acid or stearic acid, which were hardly isolated from the complex even through Lipidex 1,000 column chromatography at 37 degrees C. Temperature dependent analysis of 1H-NMR on the association between GST-P and fatty acids indicated that molecular motion of fatty acids were strongly restrained in a hydrophobic "pocket" below the temperature of protein denaturation.	Hydrogen	313-315	glutathione S-transferase pi 1	Homo sapiens	89-94
8444404-2	1993	Fatty acid analysis by gas-liquid chromatography-mass spectrometry (GC-MS) revealed that GST-P forms 1:1 complex with fatty acids, mostly palmitic acid or stearic acid, which were hardly isolated from the complex even through Lipidex 1,000 column chromatography at 37 degrees C. Temperature dependent analysis of 1H-NMR on the association between GST-P and fatty acids indicated that molecular motion of fatty acids were strongly restrained in a hydrophobic "pocket" below the temperature of protein denaturation.	Fatty Acids	357-368	glutathione S-transferase pi 1	Homo sapiens	89-94
8444404-2	1993	Fatty acid analysis by gas-liquid chromatography-mass spectrometry (GC-MS) revealed that GST-P forms 1:1 complex with fatty acids, mostly palmitic acid or stearic acid, which were hardly isolated from the complex even through Lipidex 1,000 column chromatography at 37 degrees C. Temperature dependent analysis of 1H-NMR on the association between GST-P and fatty acids indicated that molecular motion of fatty acids were strongly restrained in a hydrophobic "pocket" below the temperature of protein denaturation.	Fatty Acids	357-368	glutathione S-transferase pi 1	Homo sapiens	89-94
8444404-4	1993	The binding region was determined to be at around 142-157 residues from amino terminus by the studies of GST-P binding to fatty acid-linked Sepharose and affinity labelings with either fluorescent fatty acid or bilirubin.	Fatty Acids	122-132	glutathione S-transferase pi 1	Homo sapiens	105-110
8444404-4	1993	The binding region was determined to be at around 142-157 residues from amino terminus by the studies of GST-P binding to fatty acid-linked Sepharose and affinity labelings with either fluorescent fatty acid or bilirubin.	Sepharose	140-149	glutathione S-transferase pi 1	Homo sapiens	105-110
8444404-4	1993	The binding region was determined to be at around 142-157 residues from amino terminus by the studies of GST-P binding to fatty acid-linked Sepharose and affinity labelings with either fluorescent fatty acid or bilirubin.	Fatty Acids	197-207	glutathione S-transferase pi 1	Homo sapiens	105-110
8444404-4	1993	The binding region was determined to be at around 142-157 residues from amino terminus by the studies of GST-P binding to fatty acid-linked Sepharose and affinity labelings with either fluorescent fatty acid or bilirubin.	Bilirubin	211-220	glutathione S-transferase pi 1	Homo sapiens	105-110
8444404-2	1993	Fatty acid analysis by gas-liquid chromatography-mass spectrometry (GC-MS) revealed that GST-P forms 1:1 complex with fatty acids, mostly palmitic acid or stearic acid, which were hardly isolated from the complex even through Lipidex 1,000 column chromatography at 37 degrees C. Temperature dependent analysis of 1H-NMR on the association between GST-P and fatty acids indicated that molecular motion of fatty acids were strongly restrained in a hydrophobic "pocket" below the temperature of protein denaturation.	Fatty Acids	0-10	glutathione S-transferase pi 1	Homo sapiens	347-352
8444404-2	1993	Fatty acid analysis by gas-liquid chromatography-mass spectrometry (GC-MS) revealed that GST-P forms 1:1 complex with fatty acids, mostly palmitic acid or stearic acid, which were hardly isolated from the complex even through Lipidex 1,000 column chromatography at 37 degrees C. Temperature dependent analysis of 1H-NMR on the association between GST-P and fatty acids indicated that molecular motion of fatty acids were strongly restrained in a hydrophobic "pocket" below the temperature of protein denaturation.	Fatty Acids	118-129	glutathione S-transferase pi 1	Homo sapiens	89-94
8444404-2	1993	Fatty acid analysis by gas-liquid chromatography-mass spectrometry (GC-MS) revealed that GST-P forms 1:1 complex with fatty acids, mostly palmitic acid or stearic acid, which were hardly isolated from the complex even through Lipidex 1,000 column chromatography at 37 degrees C. Temperature dependent analysis of 1H-NMR on the association between GST-P and fatty acids indicated that molecular motion of fatty acids were strongly restrained in a hydrophobic "pocket" below the temperature of protein denaturation.	Palmitic Acid	138-151	glutathione S-transferase pi 1	Homo sapiens	89-94
8444404-2	1993	Fatty acid analysis by gas-liquid chromatography-mass spectrometry (GC-MS) revealed that GST-P forms 1:1 complex with fatty acids, mostly palmitic acid or stearic acid, which were hardly isolated from the complex even through Lipidex 1,000 column chromatography at 37 degrees C. Temperature dependent analysis of 1H-NMR on the association between GST-P and fatty acids indicated that molecular motion of fatty acids were strongly restrained in a hydrophobic "pocket" below the temperature of protein denaturation.	stearic acid	155-167	glutathione S-transferase pi 1	Homo sapiens	89-94
1472032-1	1992	1-Anilinonaphthalene-8-sulfonic acid (ANS) noncompetitively inhibited enzyme activity of glutathione S-transferase P for both glutathione and 1-chloro-2,4-dinitrobenzene (Ki = 30 microM).	1-anilino-8-naphthalenesulfonate	0-36	glutathione S-transferase pi 1	Homo sapiens	89-116
1472032-1	1992	1-Anilinonaphthalene-8-sulfonic acid (ANS) noncompetitively inhibited enzyme activity of glutathione S-transferase P for both glutathione and 1-chloro-2,4-dinitrobenzene (Ki = 30 microM).	1-anilino-8-naphthalenesulfonate	38-41	glutathione S-transferase pi 1	Homo sapiens	89-116
1472032-1	1992	1-Anilinonaphthalene-8-sulfonic acid (ANS) noncompetitively inhibited enzyme activity of glutathione S-transferase P for both glutathione and 1-chloro-2,4-dinitrobenzene (Ki = 30 microM).	Dinitrochlorobenzene	142-169	glutathione S-transferase pi 1	Homo sapiens	89-116
1417864-0	1992	Characterization of cysteine residues of glutathione S-transferase P: evidence for steric hindrance of substrate binding by a bulky adduct to cysteine 47.	Cysteine	20-28	glutathione S-transferase pi 1	Homo sapiens	41-68
1449474-0	1992	Identification of the fatty acid binding site on glutathione S-transferase P.	Fatty Acids	22-32	glutathione S-transferase pi 1	Homo sapiens	49-76
1449474-1	1992	Glutathione S-transferase P (GST-P) bound a series of endogenous fatty acids (C12-C18).	Fatty Acids	65-76	glutathione S-transferase pi 1	Homo sapiens	0-27
1449474-1	1992	Glutathione S-transferase P (GST-P) bound a series of endogenous fatty acids (C12-C18).	Fatty Acids	65-76	glutathione S-transferase pi 1	Homo sapiens	29-34
1449474-2	1992	To clarify the function and the binding site of the fatty acids, interaction between fatty acids and GST-P was investigated by using 12-(9-anthroyloxy) stearic acid conjugated with Woodward"s reagent K. The fluorescence-conjugated fatty acid noncompetitively inhibited GST activity.	Fatty Acids	52-63	glutathione S-transferase pi 1	Homo sapiens	101-106
1449474-2	1992	To clarify the function and the binding site of the fatty acids, interaction between fatty acids and GST-P was investigated by using 12-(9-anthroyloxy) stearic acid conjugated with Woodward"s reagent K. The fluorescence-conjugated fatty acid noncompetitively inhibited GST activity.	Fatty Acids	85-96	glutathione S-transferase pi 1	Homo sapiens	101-106
1449474-2	1992	To clarify the function and the binding site of the fatty acids, interaction between fatty acids and GST-P was investigated by using 12-(9-anthroyloxy) stearic acid conjugated with Woodward"s reagent K. The fluorescence-conjugated fatty acid noncompetitively inhibited GST activity.	12-(9-anthroyloxy)stearic acid	133-164	glutathione S-transferase pi 1	Homo sapiens	101-106
1449474-2	1992	To clarify the function and the binding site of the fatty acids, interaction between fatty acids and GST-P was investigated by using 12-(9-anthroyloxy) stearic acid conjugated with Woodward"s reagent K. The fluorescence-conjugated fatty acid noncompetitively inhibited GST activity.	Fatty Acids	52-62	glutathione S-transferase pi 1	Homo sapiens	101-106
1449474-3	1992	After GST-P was covalently labeled with the fatty acid, the enzyme was digested with Lysyl Endopeptidase.	Fatty Acids	44-54	glutathione S-transferase pi 1	Homo sapiens	6-11
1417864-0	1992	Characterization of cysteine residues of glutathione S-transferase P: evidence for steric hindrance of substrate binding by a bulky adduct to cysteine 47.	Cysteine	142-150	glutathione S-transferase pi 1	Homo sapiens	41-68
1417864-1	1992	Glutathione S-transferase P (GST-P) lost the enzymatic activity by 7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole (ABD-F), a thiol-group chemical modifier, but did not by methylmethanethiol-sulfonate.	7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole	67-108	glutathione S-transferase pi 1	Homo sapiens	0-27
1417864-1	1992	Glutathione S-transferase P (GST-P) lost the enzymatic activity by 7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole (ABD-F), a thiol-group chemical modifier, but did not by methylmethanethiol-sulfonate.	7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole	67-108	glutathione S-transferase pi 1	Homo sapiens	29-34
1417864-1	1992	Glutathione S-transferase P (GST-P) lost the enzymatic activity by 7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole (ABD-F), a thiol-group chemical modifier, but did not by methylmethanethiol-sulfonate.	4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole	110-115	glutathione S-transferase pi 1	Homo sapiens	0-27
1417864-1	1992	Glutathione S-transferase P (GST-P) lost the enzymatic activity by 7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole (ABD-F), a thiol-group chemical modifier, but did not by methylmethanethiol-sulfonate.	4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole	110-115	glutathione S-transferase pi 1	Homo sapiens	29-34
1417864-1	1992	Glutathione S-transferase P (GST-P) lost the enzymatic activity by 7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole (ABD-F), a thiol-group chemical modifier, but did not by methylmethanethiol-sulfonate.	Sulfhydryl Compounds	120-125	glutathione S-transferase pi 1	Homo sapiens	0-27
1408831-1	1992	Glutathione Transferase P (GST-P) gene expression is dominantly regulated by an upstream enhancer (GPEI) consisting of a dyad of palindromically oriented imperfect TPA (12-O-tetradecanoyl-phorbol-13-acetate)-responsive elements (TRE).	Tetradecanoylphorbol Acetate	164-167	glutathione S-transferase pi 1	Homo sapiens	27-32
1417864-1	1992	Glutathione S-transferase P (GST-P) lost the enzymatic activity by 7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole (ABD-F), a thiol-group chemical modifier, but did not by methylmethanethiol-sulfonate.	Sulfhydryl Compounds	120-125	glutathione S-transferase pi 1	Homo sapiens	29-34
1408831-1	1992	Glutathione Transferase P (GST-P) gene expression is dominantly regulated by an upstream enhancer (GPEI) consisting of a dyad of palindromically oriented imperfect TPA (12-O-tetradecanoyl-phorbol-13-acetate)-responsive elements (TRE).	Tetradecanoylphorbol Acetate	169-206	glutathione S-transferase pi 1	Homo sapiens	27-32
1417864-1	1992	Glutathione S-transferase P (GST-P) lost the enzymatic activity by 7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole (ABD-F), a thiol-group chemical modifier, but did not by methylmethanethiol-sulfonate.	methyl methanethiosulfonate	166-194	glutathione S-transferase pi 1	Homo sapiens	0-27
1417864-1	1992	Glutathione S-transferase P (GST-P) lost the enzymatic activity by 7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole (ABD-F), a thiol-group chemical modifier, but did not by methylmethanethiol-sulfonate.	methyl methanethiosulfonate	166-194	glutathione S-transferase pi 1	Homo sapiens	29-34
1627130-0	1992	Evidence for the involvement of tryptophan 38 in the active site of glutathione S-transferase P.	Tryptophan	32-42	glutathione S-transferase pi 1	Homo sapiens	68-95
1394838-6	1992	In accordance with previous observations with the diolepoxides of B[a]P, GST P1-1 was highly selective towards the BPhDE isomer with 4R,3S-diol 2S,1R-epoxide absolute configuration, i.e. (-)-anti-BPhDE, whereas GST A1-1 and M1-1 preferentially catalyzed the conjugation of (+)-syn-BPhDE (4R,3S-diol 2R,1S-epoxide absolute configuration).	diolepoxides	50-62	glutathione S-transferase pi 1	Homo sapiens	73-81
1394838-6	1992	In accordance with previous observations with the diolepoxides of B[a]P, GST P1-1 was highly selective towards the BPhDE isomer with 4R,3S-diol 2S,1R-epoxide absolute configuration, i.e. (-)-anti-BPhDE, whereas GST A1-1 and M1-1 preferentially catalyzed the conjugation of (+)-syn-BPhDE (4R,3S-diol 2R,1S-epoxide absolute configuration).	bphde	115-120	glutathione S-transferase pi 1	Homo sapiens	73-81
1394838-6	1992	In accordance with previous observations with the diolepoxides of B[a]P, GST P1-1 was highly selective towards the BPhDE isomer with 4R,3S-diol 2S,1R-epoxide absolute configuration, i.e. (-)-anti-BPhDE, whereas GST A1-1 and M1-1 preferentially catalyzed the conjugation of (+)-syn-BPhDE (4R,3S-diol 2R,1S-epoxide absolute configuration).	4r,3s-diol 2s,1r-epoxide	133-157	glutathione S-transferase pi 1	Homo sapiens	73-81
1394838-6	1992	In accordance with previous observations with the diolepoxides of B[a]P, GST P1-1 was highly selective towards the BPhDE isomer with 4R,3S-diol 2S,1R-epoxide absolute configuration, i.e. (-)-anti-BPhDE, whereas GST A1-1 and M1-1 preferentially catalyzed the conjugation of (+)-syn-BPhDE (4R,3S-diol 2R,1S-epoxide absolute configuration).	CCRIS 7367	187-201	glutathione S-transferase pi 1	Homo sapiens	73-81
1394838-6	1992	In accordance with previous observations with the diolepoxides of B[a]P, GST P1-1 was highly selective towards the BPhDE isomer with 4R,3S-diol 2S,1R-epoxide absolute configuration, i.e. (-)-anti-BPhDE, whereas GST A1-1 and M1-1 preferentially catalyzed the conjugation of (+)-syn-BPhDE (4R,3S-diol 2R,1S-epoxide absolute configuration).	B(c)PH diol epoxide-1	273-286	glutathione S-transferase pi 1	Homo sapiens	73-81
1394838-6	1992	In accordance with previous observations with the diolepoxides of B[a]P, GST P1-1 was highly selective towards the BPhDE isomer with 4R,3S-diol 2S,1R-epoxide absolute configuration, i.e. (-)-anti-BPhDE, whereas GST A1-1 and M1-1 preferentially catalyzed the conjugation of (+)-syn-BPhDE (4R,3S-diol 2R,1S-epoxide absolute configuration).	4r,3s-diol 2r,1s-epoxide	288-312	glutathione S-transferase pi 1	Homo sapiens	73-81
1502982-1	1992	Glutathione-S-Transferase (GST) isozymes in human lenses were investigated by the immunoenzymatic method using antibody against human liver GST2 and GST3 after polyacrylamide gel isoelectric focusing (western blotting method).	polyacrylamide	160-174	glutathione S-transferase pi 1	Homo sapiens	149-153
1627130-1	1992	Glutathione S-transferase P (GST-P) exists as a homodimeric form and has two tryptophan residues, Trp28 and Trp38, in each subunit.	Tryptophan	77-87	glutathione S-transferase pi 1	Homo sapiens	0-27
1627130-1	1992	Glutathione S-transferase P (GST-P) exists as a homodimeric form and has two tryptophan residues, Trp28 and Trp38, in each subunit.	Tryptophan	77-87	glutathione S-transferase pi 1	Homo sapiens	29-34
1627145-0	1992	Nonoxidative ethanol metabolism: expression of fatty acid ethyl ester synthase-III in cultured neural cells.	Ethanol	13-20	glutathione S-transferase pi 1	Homo sapiens	47-82
2310397-2	1990	Inactivated GST P lost its S-hexyl-GSH-Sepharose column affinity.	dipicrylamine	29-34	glutathione S-transferase pi 1	Homo sapiens	12-17
1885604-1	1991	Fatty acid ethyl ester synthase-III (FAEES-III), previously purified to homogeneity from human heart, metabolizes ethanol nonoxidatively.	Ethanol	114-121	glutathione S-transferase pi 1	Homo sapiens	0-35
1885604-1	1991	Fatty acid ethyl ester synthase-III (FAEES-III), previously purified to homogeneity from human heart, metabolizes ethanol nonoxidatively.	Ethanol	114-121	glutathione S-transferase pi 1	Homo sapiens	37-46
1885604-13	1991	Thus, we have obtained the first cDNA and amino acid sequence for a human FAEES-III which also has significant GST activity, and we have identified 4 residues potentially responsible for conferring ethanol recognition to GSTs.	Ethanol	198-205	glutathione S-transferase pi 1	Homo sapiens	74-83
1883342-9	1991	The inhibited enzyme could be re-activated by addition of 10 mM-2-mercaptoethanol: 60 min after this thiol was added, the inhibited GST-3- activity was bacxk to the control level.	Mercaptoethanol	64-81	glutathione S-transferase pi 1	Homo sapiens	132-137
1883342-9	1991	The inhibited enzyme could be re-activated by addition of 10 mM-2-mercaptoethanol: 60 min after this thiol was added, the inhibited GST-3- activity was bacxk to the control level.	Sulfhydryl Compounds	101-106	glutathione S-transferase pi 1	Homo sapiens	132-137
2310397-2	1990	Inactivated GST P lost its S-hexyl-GSH-Sepharose column affinity.	Glutathione	35-38	glutathione S-transferase pi 1	Homo sapiens	12-17
2310397-2	1990	Inactivated GST P lost its S-hexyl-GSH-Sepharose column affinity.	Sepharose	39-48	glutathione S-transferase pi 1	Homo sapiens	12-17
2310397-3	1990	About 0.8 mol of [14C]NEM was found to be covalently bound to 1 mol of GST P subunit when 80% of the activity was lost.	Carbon-14	18-21	glutathione S-transferase pi 1	Homo sapiens	71-76
2310397-4	1990	Similar treatment with N-dimethyl-amino-3,5-dinitrophenyl maleimide, a colored analogue of NEM, followed by trypsin digestion, HPLC and amino acid sequence analysis revealed that one cysteine residue at the 47th position from the N-terminal of the GST P subunit was preferentially modified.	n-dimethyl-amino-3,5-dinitrophenyl maleimide	23-67	glutathione S-transferase pi 1	Homo sapiens	248-253
2310397-4	1990	Similar treatment with N-dimethyl-amino-3,5-dinitrophenyl maleimide, a colored analogue of NEM, followed by trypsin digestion, HPLC and amino acid sequence analysis revealed that one cysteine residue at the 47th position from the N-terminal of the GST P subunit was preferentially modified.	Cysteine	183-191	glutathione S-transferase pi 1	Homo sapiens	248-253
2310397-5	1990	Subunits of GST P and GST pi are known to have 4 cysteine residues at the same corresponding positions.	Cysteine	49-57	glutathione S-transferase pi 1	Homo sapiens	12-17
25264565-2	2015	The influence of genetic polymorphisms of NAT2, UGT1A1 and GSTP1 on generation of the terminal mercapturic acid derivatives and analgesic effects was evaluated to identify potential genetic risk factors for hepatotoxicity of flupirtine.	Acetylcysteine	95-111	glutathione S-transferase pi 1	Homo sapiens	59-64
2134681-11	1990	In addition, combined treatment with five heterocyclic amines yielded additive or synergistic effects in the development of glutathione S-transferase placental form (GST-P) positive foci.	Amines	55-61	glutathione S-transferase pi 1	Homo sapiens	124-171
26151571-0	2015	Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides.	diselenides	90-101	glutathione S-transferase pi 1	Homo sapiens	0-28
25264565-8	2015	Carriers of variant GSTP1 alleles showed lower bioavailability but increased intestinal secretion of flupirtine and increased efficiency in experimental pain.	flupirtine	101-111	glutathione S-transferase pi 1	Homo sapiens	20-25
34453679-9	2022	The susceptibility analysis using 10 mug dL-1 as blood Pb cutoff level showed a high risk of Pb toxicity (OR = 2.54; 95% CI: 1.02-6.32, p = 0.04) for children carrying the GSTP1 Ile/Val genotype.	Lead	93-95	glutathione S-transferase pi 1	Homo sapiens	172-177
26151571-1	2015	Glutathione S-transferase pi (GSTP), a phase II gene downstream of the nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant-responsive element (ARE)/electrophile response element (EpRE) transcription pathway, plays a key role in both the signaling and detoxification response to Se-organic compounds with thiol peroxidase activity.	Selenium	289-291	glutathione S-transferase pi 1	Homo sapiens	0-28
26151571-1	2015	Glutathione S-transferase pi (GSTP), a phase II gene downstream of the nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant-responsive element (ARE)/electrophile response element (EpRE) transcription pathway, plays a key role in both the signaling and detoxification response to Se-organic compounds with thiol peroxidase activity.	Selenium	289-291	glutathione S-transferase pi 1	Homo sapiens	30-34
26151571-2	2015	We here investigated the role of GSTP on the Nrf2 activation response of cells challenged with a new class of diselenides derived from the basic structure of diphenyl diselenide [(PhSe)2].	diselenides	110-121	glutathione S-transferase pi 1	Homo sapiens	33-37
26151571-4	2015	Used in murine embryonic fibroblasts (MEFs) and HepG2 human hepatocarcinoma cells to produce submaximal conditions of stress, the diselenide compounds stimulated Nrf2 nuclear translocation and then the transcription of the same Nrf2 gene as well as of GSTP and other phase II genes.	diselenium	130-140	glutathione S-transferase pi 1	Homo sapiens	252-256
26151571-6	2015	Diselenide toxicity increased in GSTP knockout MEFs by a higher generation of NOx and stress activated protein kinase (SAPK)/JNK activation.	diselenium	0-10	glutathione S-transferase pi 1	Homo sapiens	33-37
26151571-6	2015	Diselenide toxicity increased in GSTP knockout MEFs by a higher generation of NOx and stress activated protein kinase (SAPK)/JNK activation.	nicotine 1-N-oxide	78-81	glutathione S-transferase pi 1	Homo sapiens	33-37
26151571-9	2015	Covalent oligomers of GSTP subunits were observed in DSBA-treated HepG2 cells.	DSBA	53-57	glutathione S-transferase pi 1	Homo sapiens	22-26
26151571-10	2015	In conclusion, GSTP gene expression influences the Nrf2-dependent response to hormetic diselenides.	diselenides	87-98	glutathione S-transferase pi 1	Homo sapiens	15-19
34689350-1	2022	Over 50% prescribed drugs are metabolized by cytochrome P450 3A (CYP3A) and glutathione S-transferase pi (GSTP1) adds a glutathione to the oxidative products by CYP3A, which increases the hydrophilic property of metabolites and facilitates the excretion.	Glutathione	76-87	glutathione S-transferase pi 1	Homo sapiens	106-111
34689350-1	2022	Over 50% prescribed drugs are metabolized by cytochrome P450 3A (CYP3A) and glutathione S-transferase pi (GSTP1) adds a glutathione to the oxidative products by CYP3A, which increases the hydrophilic property of metabolites and facilitates the excretion.	Glutathione	120-131	glutathione S-transferase pi 1	Homo sapiens	106-111
25063807-4	2014	The acquisition of vemurafenib resistance was associated with significantly increased NRAS levels in A375rVem and D443rVem, increased activation of the prosurvival protein, AKT, and the MAPKs, ERK, JNK, and P38, which correlated with decreased levels of the MAPK inhibitor protein, GSTP1.	Vemurafenib	19-30	glutathione S-transferase pi 1	Homo sapiens	282-287
34453679-10	2022	Further, the combined effect of GSTP1 Ile/Val with GSTT1 null genotype was more pronounced and showed an increased risk of susceptibility to Pb toxicity (OR = 11.7; 95% CI: 1.36-102.1, p = 0.02).	Lead	141-143	glutathione S-transferase pi 1	Homo sapiens	32-37
34453679-11	2022	In summary, this study suggests that GSTT1 null and GSTP1 Ile/Val genotypes are the main genetic factors, and individual and specific combinations of GSTP1 Ile/Val with GSTM1 and GSTT1 GST polymorphisms are associated with susceptibility to Pb toxicity.	Lead	241-243	glutathione S-transferase pi 1	Homo sapiens	52-57
34347217-2	2022	In addition, glutathione S transferase (GST) P1 is involved in the metabolism of platinum agents.	Platinum	81-89	glutathione S-transferase pi 1	Homo sapiens	13-47
34453679-11	2022	In summary, this study suggests that GSTT1 null and GSTP1 Ile/Val genotypes are the main genetic factors, and individual and specific combinations of GSTP1 Ile/Val with GSTM1 and GSTT1 GST polymorphisms are associated with susceptibility to Pb toxicity.	Lead	241-243	glutathione S-transferase pi 1	Homo sapiens	150-155
34988113-2	2021	The distribution of polymorphisms in cytosolic glutathione S-transferases GSTA1, GSTM1, GSTM3, GSTP1 (rs1695 and rs1138272), and GSTT1 were assessed in 207 COVID-19 patients and 252 matched healthy individuals, emphasizing their individual and cumulative effect in disease development and severity.	Glutathione	47-58	glutathione S-transferase pi 1	Homo sapiens	95-100
34951099-3	2022	Our results showed markedly diminished levels of GSTP1 and HSPB1 proteins in ALKBH4-depleted cells, which emanate from an augmented expression level of DNA (cytosine-5)-methyltransferase 1 (DNMT1) and the ensuing elevated cytosine methylation in the promoter regions of GSTP1 and HSPB1 genes.	Cytosine	222-230	glutathione S-transferase pi 1	Homo sapiens	49-54
34951099-3	2022	Our results showed markedly diminished levels of GSTP1 and HSPB1 proteins in ALKBH4-depleted cells, which emanate from an augmented expression level of DNA (cytosine-5)-methyltransferase 1 (DNMT1) and the ensuing elevated cytosine methylation in the promoter regions of GSTP1 and HSPB1 genes.	Cytosine	222-230	glutathione S-transferase pi 1	Homo sapiens	270-275
34623802-3	2021	Here, we have studied, for the first time, the proteome reactivity of cyclopropenones in live cells and discovered that the cyclopropenone warhead can specifically and efficiently modify a triple-negative breast cancer driver, glutathione S-transferase pi-1 (GSTP1), by covalently binding at the catalytic active site.	cyclopropenone	70-85	glutathione S-transferase pi 1	Homo sapiens	227-257
34965566-14	2021	One of the leading mechanisms, due to which there is a realization of hereditary predisposition tobronchial asthma in children living under constant intake of radionuclides with a long half-life, is the polymorphismof certain glutathione-S-transferase genes, namely, GSTT1, GSTM1 and A313G gene deletion polymorphism and GSTP1gene polymorphism.	Radioisotopes	159-172	glutathione S-transferase pi 1	Homo sapiens	321-326
34780261-1	2021	BACKGROUND: Genetic polymorphism within the P1 isoenzyme of the Glutathione-S-Transferase (GST) family is found to modulate and alter the enzyme activity of GSTP1 protein and thus may result in a change of sensitivity to platinum-based chemotherapy.	Platinum	221-229	glutathione S-transferase pi 1	Homo sapiens	157-162
34780261-8	2021	CONCLUSIONS: Our results suggest that GSTP1 Ile105Val polymorphism could be a predictive biomarker for hematological toxicity, like leukopenia and anemia, but not thrombocytopenia or neutropenia.	ile105val	44-53	glutathione S-transferase pi 1	Homo sapiens	38-43
34623802-3	2021	Here, we have studied, for the first time, the proteome reactivity of cyclopropenones in live cells and discovered that the cyclopropenone warhead can specifically and efficiently modify a triple-negative breast cancer driver, glutathione S-transferase pi-1 (GSTP1), by covalently binding at the catalytic active site.	cyclopropenone	70-85	glutathione S-transferase pi 1	Homo sapiens	259-264
34623802-3	2021	Here, we have studied, for the first time, the proteome reactivity of cyclopropenones in live cells and discovered that the cyclopropenone warhead can specifically and efficiently modify a triple-negative breast cancer driver, glutathione S-transferase pi-1 (GSTP1), by covalently binding at the catalytic active site.	cyclopropenone	124-138	glutathione S-transferase pi 1	Homo sapiens	227-257
34623802-3	2021	Here, we have studied, for the first time, the proteome reactivity of cyclopropenones in live cells and discovered that the cyclopropenone warhead can specifically and efficiently modify a triple-negative breast cancer driver, glutathione S-transferase pi-1 (GSTP1), by covalently binding at the catalytic active site.	cyclopropenone	124-138	glutathione S-transferase pi 1	Homo sapiens	259-264
34509058-0	2021	Corrigendum to "Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1" (Biochem.	Paclitaxel	40-50	glutathione S-transferase pi 1	Homo sapiens	95-100
34754622-18	2021	At a concentration of 20 muM curcumin cultured for 48 h, the expression of TGFB1 and GSTP1 in Hep3B cells was reduced significantly in qPCR analysis, and reduced TGFB1 protein expression was also found in Hep3B cells.	Curcumin	29-37	glutathione S-transferase pi 1	Homo sapiens	85-90
34834443-9	2021	There was an association (not statistically significant) between the level of BPA in the blood and the presence of the G allele of the GSTP1 gene (rs1695) and the C allele in the GSTP1 gene (rs1138272).	bisphenol A	78-81	glutathione S-transferase pi 1	Homo sapiens	135-140
34641326-4	2021	Our laboratory has previously examined this hypothesis in tumor cells and has demonstrated that dinitrosyl-dithiol-iron-complexes are transported and stored by multi-drug resistance-related protein 1 and glutathione-S-transferase P1.	dinitrosyl-dithiol	96-114	glutathione S-transferase pi 1	Homo sapiens	204-232
34834443-9	2021	There was an association (not statistically significant) between the level of BPA in the blood and the presence of the G allele of the GSTP1 gene (rs1695) and the C allele in the GSTP1 gene (rs1138272).	bisphenol A	78-81	glutathione S-transferase pi 1	Homo sapiens	179-184
34623592-1	2022	BACKGROUND: Glutathione S-transferase Pi (GSTP1) enzyme has a major antioxidant effect on the central nervous system (CNS), where it acts against oxidative damage, an established risk factor for amyotrophic lateral sclerosis (ALS).	Glutathione	12-23	glutathione S-transferase pi 1	Homo sapiens	42-47
34676202-11	2021	In metformin-treated samples, the CEBPA, TP53 and USF1 transcription factors appeared to be involved in the regulation of several factors (SOD1, SOD2, CAT, GLRX, GSTP1) blocking ROS.	Metformin	3-12	glutathione S-transferase pi 1	Homo sapiens	162-167
34676202-11	2021	In metformin-treated samples, the CEBPA, TP53 and USF1 transcription factors appeared to be involved in the regulation of several factors (SOD1, SOD2, CAT, GLRX, GSTP1) blocking ROS.	Reactive Oxygen Species	178-181	glutathione S-transferase pi 1	Homo sapiens	162-167
34641326-4	2021	Our laboratory has previously examined this hypothesis in tumor cells and has demonstrated that dinitrosyl-dithiol-iron-complexes are transported and stored by multi-drug resistance-related protein 1 and glutathione-S-transferase P1.	Iron	115-119	glutathione S-transferase pi 1	Homo sapiens	204-232
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	dinitrosyl-dithiol	25-43	glutathione S-transferase pi 1	Homo sapiens	62-90
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	dinitrosyl-dithiol	25-43	glutathione S-transferase pi 1	Homo sapiens	152-180
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	Iron	44-48	glutathione S-transferase pi 1	Homo sapiens	62-90
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	Iron	44-48	glutathione S-transferase pi 1	Homo sapiens	152-180
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	Tyrosine	132-140	glutathione S-transferase pi 1	Homo sapiens	62-90
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	Tyrosine	132-140	glutathione S-transferase pi 1	Homo sapiens	152-180
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	dinitrosyl-dithiol	208-226	glutathione S-transferase pi 1	Homo sapiens	62-90
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	dinitrosyl-dithiol	208-226	glutathione S-transferase pi 1	Homo sapiens	152-180
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	Iron	227-231	glutathione S-transferase pi 1	Homo sapiens	62-90
34641326-5	2021	A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes.	Iron	227-231	glutathione S-transferase pi 1	Homo sapiens	152-180
34120541-7	2022	The combinations of XAN with PEITC and RES with PEITC increased mostly the expression of SOD, GSTP, CAT, and GPx.	phenethyl isothiocyanate	29-34	glutathione S-transferase pi 1	Homo sapiens	94-98
34164774-5	2021	circ-CHI3L1.2 knockdown decreased the half-maximal inhibitory concentration (IC50) of cisplatin and the expression levels of P-glycoprotein (P-gp), multidrug-resistance protein 1 (MRP1), and glutathione-S-transferase Pi1 (GSTP1), and promoted apoptosis of cisplatin-resistant osteosarcoma cells.	Cisplatin	86-95	glutathione S-transferase pi 1	Homo sapiens	191-220
34292981-0	2021	Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis.	ile105val	21-30	glutathione S-transferase pi 1	Homo sapiens	15-20
34292981-1	2021	BACKGROUND: Numerous case-control studies have investigated the association between GSTP1 Ile105Val polymorphism and CHD risk, but the results from published studies were inconclusive.	ile105val	90-99	glutathione S-transferase pi 1	Homo sapiens	84-89
34893156-7	2021	The polymorphism rs1695 of the GSTP1 gene has been associated with the effectiveness and toxicity of fluorouracil, cyclophosphamide and epirubicin therapy.	Fluorouracil	101-113	glutathione S-transferase pi 1	Homo sapiens	31-36
34893156-7	2021	The polymorphism rs1695 of the GSTP1 gene has been associated with the effectiveness and toxicity of fluorouracil, cyclophosphamide and epirubicin therapy.	Cyclophosphamide	115-131	glutathione S-transferase pi 1	Homo sapiens	31-36
34893156-7	2021	The polymorphism rs1695 of the GSTP1 gene has been associated with the effectiveness and toxicity of fluorouracil, cyclophosphamide and epirubicin therapy.	Epirubicin	136-146	glutathione S-transferase pi 1	Homo sapiens	31-36
34803013-0	2021	Correlation of GSTP1 rs1695 and CAT rs769217 with elevated AST induced by valproate sodium in Chinese children with epilepsy.	Valproic Acid	74-90	glutathione S-transferase pi 1	Homo sapiens	15-20
34803013-6	2021	During VPA monotherapy, the maximum AST in patients of GSTP1 rs1695 with AA genotype was significantly higher than carrying G alleles (36.50 +-14.89 vs 32.88+-10.69, P=0.003).	Valproic Acid	7-10	glutathione S-transferase pi 1	Homo sapiens	55-60
34430738-1	2021	RAPTA-EA1 is a promising glutathione transferase (GSTP-1) inhibitor that has previously been shown to inhibit the growth of various breast cancer cells.	rapta-ea1	0-9	glutathione S-transferase pi 1	Homo sapiens	50-56
34430738-1	2021	RAPTA-EA1 is a promising glutathione transferase (GSTP-1) inhibitor that has previously been shown to inhibit the growth of various breast cancer cells.	Glutathione	25-36	glutathione S-transferase pi 1	Homo sapiens	50-56
34395436-4	2021	Results: A total of 3,963 differentially expressed genes (DEGs) related to doxorubicin resistance were identified, including dramatically up-regulated MT1E, GSTP1, LDHB, significantly down-regulated TFF1, UBB, DSCAM-AS1, and histone-modifying enzyme coding genes HDAC2, EZH2, PRMT5, etc.	Doxorubicin	75-86	glutathione S-transferase pi 1	Homo sapiens	157-162
34191807-1	2021	GSTP1 is a member of the Glutathione-S-transferase (GST) family silenced by CpG island DNA hypermethylation in 90-95% of prostate cancers.	Glutathione	25-36	glutathione S-transferase pi 1	Homo sapiens	0-5
34191807-4	2021	GSTP1 protein was positive in at least one TMA core in 7.7% of cases and in all TMA cores in 4.4% of cases.	tma	43-46	glutathione S-transferase pi 1	Homo sapiens	0-5
34191807-6	2021	Further, the percentages of tumors from Black patients who had all TMA spots positive for GSTP1 (9.5%) was 3-fold higher than the percentage from White patients (3.2%; P<0.001).	tma	67-70	glutathione S-transferase pi 1	Homo sapiens	90-95
34120541-7	2022	The combinations of XAN with PEITC and RES with PEITC increased mostly the expression of SOD, GSTP, CAT, and GPx.	phenethyl isothiocyanate	48-53	glutathione S-transferase pi 1	Homo sapiens	94-98
35344726-4	2022	To explore a possible link between these enzymes and bitter taste perception, we demonstrate that salivary glutathione transferases (GSTA1 and GSTP1) can metabolize bitter molecules.	Glutathione	107-118	glutathione S-transferase pi 1	Homo sapiens	143-148
34121709-4	2021	Glutathione S-transferase P1 (GSTP1) is an enzyme involved in the detoxification process that reduces oxidative stress by reducing the number of free oxygen radicals.	free oxygen radicals	145-165	glutathione S-transferase pi 1	Homo sapiens	0-28
34121709-4	2021	Glutathione S-transferase P1 (GSTP1) is an enzyme involved in the detoxification process that reduces oxidative stress by reducing the number of free oxygen radicals.	free oxygen radicals	145-165	glutathione S-transferase pi 1	Homo sapiens	30-35
34121709-5	2021	Aim: This study aimed to investigate the relationship between GSTP1 polymorphism and early complications of allo-HSCT, iron parameters, overall survival (OS), and transplantation-related mortality (TRM).	Iron	119-123	glutathione S-transferase pi 1	Homo sapiens	62-67
35527244-9	2022	Whereas, homozygous GSTP1 and GSTT1 null genotype is significantly higher only among nilotinib non-responders.	nilotinib	85-94	glutathione S-transferase pi 1	Homo sapiens	20-25
34749598-5	2021	METHODS: Induction of oxidative stress via H2O2 treatment produced cell cytotoxicity in a dose dependent manner and also led to the over expression of GSTP-1 and PRX-2.	Hydrogen Peroxide	43-47	glutathione S-transferase pi 1	Homo sapiens	151-157
35527244-10	2022	CONCLUSION: Hence, it can be concluded that wild type CYP1A1, GSTP1 and null GSTM1 may be frequently linked to favorable outcome in patients treated with nilotinib as depicted by sustained deep molecular response in most CML patients.	nilotinib	154-163	glutathione S-transferase pi 1	Homo sapiens	62-67
35524288-3	2022	Cd toxicity in SCs resulted in impaired viability and function, abnormal H2 O2 generation and efflux, and induction of reductive stress by the upregulation of Nrf2 expression and activity, of cystine uptake and use in cellular glutathione biosynthesis, and glutathione-S-transferase P (GSTP) expression, whereas protein glutathionylation was reduced.	Cadmium	0-2	glutathione S-transferase pi 1	Homo sapiens	257-284
35524288-3	2022	Cd toxicity in SCs resulted in impaired viability and function, abnormal H2 O2 generation and efflux, and induction of reductive stress by the upregulation of Nrf2 expression and activity, of cystine uptake and use in cellular glutathione biosynthesis, and glutathione-S-transferase P (GSTP) expression, whereas protein glutathionylation was reduced.	Cadmium	0-2	glutathione S-transferase pi 1	Homo sapiens	286-290
35524288-6	2022	Mechanistically, these effects of MLT were associated with a significant reduction of Cd-induced Nrf2 activation and GSTP expression at all Cd concentrations.	Cadmium	86-88	glutathione S-transferase pi 1	Homo sapiens	117-121
35501422-12	2022	CONCLUSION: Docetaxel effectiveness was influenced by SNPs in GSTP1, CYP3A, and SLCO1B1 in premenopausal women with non-distant metastatic breast cancer, likely related to altered docetaxel pharmacokinetics.	Docetaxel	12-21	glutathione S-transferase pi 1	Homo sapiens	62-67
35501422-12	2022	CONCLUSION: Docetaxel effectiveness was influenced by SNPs in GSTP1, CYP3A, and SLCO1B1 in premenopausal women with non-distant metastatic breast cancer, likely related to altered docetaxel pharmacokinetics.	Docetaxel	180-189	glutathione S-transferase pi 1	Homo sapiens	62-67
35215476-9	2022	These carotenoids are concentrated by the action of specific binding proteins such as StARD3, which binds lutein, and GSTP1, which binds zeaxanthin and its dietary metabolite, mesozeaxanthin.	Carotenoids	6-17	glutathione S-transferase pi 1	Homo sapiens	118-123
35465297-1	2022	Objective: To determine the efficacy and safety of intermittent docetaxel chemotherapy guided by circulating methylated glutathione S-transferase Pi-1 (mGSTP1) in men with metastatic castration-resistant prostate cancer (CRPC).	Docetaxel	64-73	glutathione S-transferase pi 1	Homo sapiens	120-150
35459441-0	2022	MiR-513a-3p promotes radiation-induced apoptosis of human lung cells by inhibiting glutathione S-transferase P1.	mir-513a-3p	0-11	glutathione S-transferase pi 1	Homo sapiens	83-111
35455437-0	2022	Association between Genetic Polymorphism of GSTP1 and Toxicities in Patients Receiving Platinum-Based Chemotherapy: A Systematic Review and Meta-Analysis.	Platinum	87-95	glutathione S-transferase pi 1	Homo sapiens	44-49
35455437-3	2022	Polymorphisms within the glutathione S-transferase pi 1 (GSTP1) gene may especially alter enzyme activity and, consequently, various toxicities in patients receiving platinum-based chemotherapy.	Platinum	166-174	glutathione S-transferase pi 1	Homo sapiens	25-55
35455437-3	2022	Polymorphisms within the glutathione S-transferase pi 1 (GSTP1) gene may especially alter enzyme activity and, consequently, various toxicities in patients receiving platinum-based chemotherapy.	Platinum	166-174	glutathione S-transferase pi 1	Homo sapiens	57-62
35455437-4	2022	Due to a lack of consistency in the degree of elevated complication risk, we performed a systematic literature review and meta-analysis to determine the level of platinum-associated toxicity in patients with the GSTP1 rs1695 polymorphism.	Platinum	162-170	glutathione S-transferase pi 1	Homo sapiens	212-217
35455437-10	2022	Our study found that the GSTP1 rs1695 polymorphism was significantly correlated with platinum-induced toxicities.	Platinum	85-93	glutathione S-transferase pi 1	Homo sapiens	25-30
35193440-0	2022	Alterations of DNA methylation and mRNA levels of CYP1A1, GSTP1, and GSTM1 in human bronchial epithelial cells induced by benzo(a)pyrene.	Benzo(a)pyrene	122-136	glutathione S-transferase pi 1	Homo sapiens	58-63
35193440-6	2022	The mRNA levels of CYP1A1, GSTP1, and GSTM1 were significantly decreased in 16HBEs following B(a)P treatment at all three doses.	Benzo(a)pyrene	93-98	glutathione S-transferase pi 1	Homo sapiens	27-32
35215476-9	2022	These carotenoids are concentrated by the action of specific binding proteins such as StARD3, which binds lutein, and GSTP1, which binds zeaxanthin and its dietary metabolite, mesozeaxanthin.	Zeaxanthins	137-147	glutathione S-transferase pi 1	Homo sapiens	118-123
35215476-9	2022	These carotenoids are concentrated by the action of specific binding proteins such as StARD3, which binds lutein, and GSTP1, which binds zeaxanthin and its dietary metabolite, mesozeaxanthin.	meso-zeaxanthin	176-190	glutathione S-transferase pi 1	Homo sapiens	118-123
6743340-5	1984	It is suggested that GST3 isoenzyme activity depends on vitamin A.	Vitamin A	56-65	glutathione S-transferase pi 1	Homo sapiens	21-25
3570286-7	1987	The apparent Km values with 1-chloro-2,4-dinitrobenzene (CDNB) as substrate for the isozymes at the GST1, GST2, GST3, and GST4 loci were 604, 1345, 776, and 591 microM, respectively.	Dinitrochlorobenzene	28-55	glutathione S-transferase pi 1	Homo sapiens	112-116
3570286-7	1987	The apparent Km values with 1-chloro-2,4-dinitrobenzene (CDNB) as substrate for the isozymes at the GST1, GST2, GST3, and GST4 loci were 604, 1345, 776, and 591 microM, respectively.	Dinitrochlorobenzene	57-61	glutathione S-transferase pi 1	Homo sapiens	112-116
35124341-0	2022	Impact of glutathione S transferases P1 (Ile105Val) variants on the risk of GSTp, phosphorylated c-Jun kinase, and P53 phenotypic expression and their implications on overall survival outcomes in non-small cell lung cancer patients treated with chemotherapy.	Glutathione	10-21	glutathione S-transferase pi 1	Homo sapiens	76-80
2699723-3	1989	GST-P+ hepatocytes proliferate after selection for resistance to 2-acetylaminofluorene, and persist in the absence of selection for 6 weeks.	2-Acetylaminofluorene	65-86	glutathione S-transferase pi 1	Homo sapiens	0-5
3200831-10	1988	Phorbol 12-O-tetradecanoate 13-acetate enhanced the expression of the transfected GST-P gene to a much higher degree in HeLa cells than in the hepatoma cells, which constitutively expressed the endogenous GST-P.	phorbol 12-o-tetradecanoate 13-acetate	0-38	glutathione S-transferase pi 1	Homo sapiens	82-87
3200831-10	1988	Phorbol 12-O-tetradecanoate 13-acetate enhanced the expression of the transfected GST-P gene to a much higher degree in HeLa cells than in the hepatoma cells, which constitutively expressed the endogenous GST-P.	phorbol 12-o-tetradecanoate 13-acetate	0-38	glutathione S-transferase pi 1	Homo sapiens	205-210
3130353-1	1988	Development of glutathione S-transferase placental form (GST-P)-positive focal populations was investigated subsequent to single injections of the hepatocarcinogens aflatoxin B1 (AfB1), dimethylnitrosamine (DMN) and diethylnitrosamine (DEN).	Dimethylnitrosamine	186-205	glutathione S-transferase pi 1	Homo sapiens	15-62
3130353-1	1988	Development of glutathione S-transferase placental form (GST-P)-positive focal populations was investigated subsequent to single injections of the hepatocarcinogens aflatoxin B1 (AfB1), dimethylnitrosamine (DMN) and diethylnitrosamine (DEN).	Dimethylnitrosamine	207-210	glutathione S-transferase pi 1	Homo sapiens	15-62
3130353-1	1988	Development of glutathione S-transferase placental form (GST-P)-positive focal populations was investigated subsequent to single injections of the hepatocarcinogens aflatoxin B1 (AfB1), dimethylnitrosamine (DMN) and diethylnitrosamine (DEN).	Diethylnitrosamine	216-234	glutathione S-transferase pi 1	Homo sapiens	15-62
3130353-1	1988	Development of glutathione S-transferase placental form (GST-P)-positive focal populations was investigated subsequent to single injections of the hepatocarcinogens aflatoxin B1 (AfB1), dimethylnitrosamine (DMN) and diethylnitrosamine (DEN).	Diethylnitrosamine	236-239	glutathione S-transferase pi 1	Homo sapiens	15-62
3815743-1	1987	Immunohistochemical investigation of liver tissue 48 h after single doses of the hepatocarcinogens diethylnitrosamine (DEN), dimethylnitrosamine, aflatoxin B1 and methylazoxymethanol acetate revealed the generation of a population of single glutathione S-transferase placental form (GST-P) positive hepatocytes.	Aflatoxin B1	146-158	glutathione S-transferase pi 1	Homo sapiens	241-288
3815743-1	1987	Immunohistochemical investigation of liver tissue 48 h after single doses of the hepatocarcinogens diethylnitrosamine (DEN), dimethylnitrosamine, aflatoxin B1 and methylazoxymethanol acetate revealed the generation of a population of single glutathione S-transferase placental form (GST-P) positive hepatocytes.	Methylazoxymethanol Acetate	163-190	glutathione S-transferase pi 1	Homo sapiens	241-288
3815743-5	1987	The results gained from investigation of the effects of 3-aminobenzamide administration and partial hepatectomy carried out at different times after carcinogen treatment also pointed to an "initiated" character for the lesions and suggest that GST-P may be a useful marker for analyzing factors relevant to the initiation stage of hepatocarcinogenesis.	3-aminobenzamide	56-72	glutathione S-transferase pi 1	Homo sapiens	244-249
4084207-1	1985	The expression of the GST1, GST2, and GST3 loci in fetal, neonatal, and infant tissues has been studied using starch gel electrophoresis and chromatofocusing.	Starch	110-116	glutathione S-transferase pi 1	Homo sapiens	38-42
34052967-3	2021	The aim of this study is to investigate whether individual or combined modifying effects of LOX G/A, GSTM1 active/null, GSTT1 active/null and GSTP1 Ile/Val polymorphisms are related to the risk of lung cancer in relation to smoking in the Egyptian population.	Valine	152-155	glutathione S-transferase pi 1	Homo sapiens	142-147
34052967-3	2021	The aim of this study is to investigate whether individual or combined modifying effects of LOX G/A, GSTM1 active/null, GSTT1 active/null and GSTP1 Ile/Val polymorphisms are related to the risk of lung cancer in relation to smoking in the Egyptian population.	Isoleucine	148-151	glutathione S-transferase pi 1	Homo sapiens	142-147
34059446-9	2021	CONCLUSION: The GSTP1 SNP may be a predictive marker for small bowel bleeding among patients taking LDA.	lda	100-103	glutathione S-transferase pi 1	Homo sapiens	16-21
33635505-4	2021	Consequently, (+)-usnic acid enhanced the transcription and translation of Nrf2 target genes: NQO1, SOD, and to a lesser extent, GSTP.	usnic acid	18-28	glutathione S-transferase pi 1	Homo sapiens	129-133
34050450-6	2021	The hypomethylation of GSTP1 and MGMT was accompanied by an increase in gene expression levels in the group treated with doxorubicin only.	Doxorubicin	121-132	glutathione S-transferase pi 1	Homo sapiens	23-28
33539969-6	2021	GSTP1-1, which produces regioisomers in order 1,2-trans-DCVG > 2,2-cis-DCVG > 1,2-cis-DCVG, is likely to contribute to extrahepatic GSH-conjugation of TCE.	1,2-trans-dcvg	46-60	glutathione S-transferase pi 1	Homo sapiens	0-7
33640700-7	2021	Critical cellular proteins such as the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the detoxification enzyme glutathione S-transferase P (GSTP1) appeared as top hits, and N3-AZA adduct formation significantly reduced their enzymatic activities only under hypoxia.	n3-aza	198-204	glutathione S-transferase pi 1	Homo sapiens	165-170
33640700-8	2021	Therefore, GAPDH, GSTP1 and other proteins reported here may represent candidate targets to further enhance the potential for nitroimidazole-based cancer therapeutics.	Nitroimidazoles	126-140	glutathione S-transferase pi 1	Homo sapiens	18-23
33960160-5	2021	We obtained genomic DNA from blood leukocytes and studied the gene polymorphisms of glutathione-S-transferase GSTP1 (Ile/Val) (A313G; rs1695) in real time.	Valine	121-124	glutathione S-transferase pi 1	Homo sapiens	110-115
33960160-8	2021	For GSTP1 (Ile/Val) polymorphism (A313G, rs1695), significant differences in the distribution of genotype frequencies in the subgroup of men with teratospermia (2=7.00; p=0.03) were revealed.	Valine	15-18	glutathione S-transferase pi 1	Homo sapiens	4-9
33960160-11	2021	DISCUSSION: Glutathione-S-transferase (GSTP1) is a multifunctional protein that protects sperm cells from the damaging effects of reactive oxygen species and xenobiotics.	Reactive Oxygen Species	130-153	glutathione S-transferase pi 1	Homo sapiens	39-44
33539969-6	2021	GSTP1-1, which produces regioisomers in order 1,2-trans-DCVG > 2,2-cis-DCVG > 1,2-cis-DCVG, is likely to contribute to extrahepatic GSH-conjugation of TCE.	2,2-cis-dcvg	63-75	glutathione S-transferase pi 1	Homo sapiens	0-7
33539969-6	2021	GSTP1-1, which produces regioisomers in order 1,2-trans-DCVG > 2,2-cis-DCVG > 1,2-cis-DCVG, is likely to contribute to extrahepatic GSH-conjugation of TCE.	1,2-cis-dcvg	78-90	glutathione S-transferase pi 1	Homo sapiens	0-7
33539969-6	2021	GSTP1-1, which produces regioisomers in order 1,2-trans-DCVG > 2,2-cis-DCVG > 1,2-cis-DCVG, is likely to contribute to extrahepatic GSH-conjugation of TCE.	Glutathione	132-135	glutathione S-transferase pi 1	Homo sapiens	0-7
33539969-6	2021	GSTP1-1, which produces regioisomers in order 1,2-trans-DCVG > 2,2-cis-DCVG > 1,2-cis-DCVG, is likely to contribute to extrahepatic GSH-conjugation of TCE.	Trichloroethylene	151-154	glutathione S-transferase pi 1	Homo sapiens	0-7
33143897-6	2021	Moreover, metal exposure did not impact GSH, GPX, and GST; however, negative associations were observed between %CH3-CpG-GPX1 and %CH3-CpG-GSTP1, and the activities of GPX and GST, respectively.	Metals	10-15	glutathione S-transferase pi 1	Homo sapiens	139-144
33922540-4	2021	The results suggest that polymorphisms detected in the GSTP1, ITGA4, NQO1, AKT1, and GP6 genes, for treatment with natalizumab, ZMIZ1, for fingolimod and dimethyl fumarate, ADA, for cladribine, and NOX3, for dimethyl fumarate, may be used in the future as predictive markers of treatment response to new therapies in MS patients.	Fingolimod Hydrochloride	139-149	glutathione S-transferase pi 1	Homo sapiens	55-60
33922540-4	2021	The results suggest that polymorphisms detected in the GSTP1, ITGA4, NQO1, AKT1, and GP6 genes, for treatment with natalizumab, ZMIZ1, for fingolimod and dimethyl fumarate, ADA, for cladribine, and NOX3, for dimethyl fumarate, may be used in the future as predictive markers of treatment response to new therapies in MS patients.	Dimethyl Fumarate	154-171	glutathione S-transferase pi 1	Homo sapiens	55-60
33922540-4	2021	The results suggest that polymorphisms detected in the GSTP1, ITGA4, NQO1, AKT1, and GP6 genes, for treatment with natalizumab, ZMIZ1, for fingolimod and dimethyl fumarate, ADA, for cladribine, and NOX3, for dimethyl fumarate, may be used in the future as predictive markers of treatment response to new therapies in MS patients.	Cladribine	182-192	glutathione S-transferase pi 1	Homo sapiens	55-60
33922540-4	2021	The results suggest that polymorphisms detected in the GSTP1, ITGA4, NQO1, AKT1, and GP6 genes, for treatment with natalizumab, ZMIZ1, for fingolimod and dimethyl fumarate, ADA, for cladribine, and NOX3, for dimethyl fumarate, may be used in the future as predictive markers of treatment response to new therapies in MS patients.	Dimethyl Fumarate	208-225	glutathione S-transferase pi 1	Homo sapiens	55-60
33392841-4	2021	PCR-RFLP was employed to genotype the mono-nucleotide variation in CYP1A1, NQO1, and GST-P1, and allele-specific PCR was used to detect the deletion polymorphism in GST-T1 and GST-M1 genes.	mono-nucleotide	38-53	glutathione S-transferase pi 1	Homo sapiens	85-91
33443393-0	2021	The Relationship Between GSTT1, GSTM1, GSTO1, GSTP1 and MTHFR Gene Polymorphisms and DNA Damage of BRCA1 and BRCA2 Genes in Arsenic-Exposed Workers.	Arsenic	124-131	glutathione S-transferase pi 1	Homo sapiens	46-51
32791162-8	2021	There were weak associations of variants in co-trimoxazole-related metabolizing enzymes (CYP2D6, GSTP1, GCLC, NAT2, and CYP2C8).	Trimethoprim, Sulfamethoxazole Drug Combination	44-58	glutathione S-transferase pi 1	Homo sapiens	97-102
33522144-4	2021	In this work, it is uncovered that metal-protein nanoparticles designated GSTP1-MT3(Fe2+ ) (MPNP) can polarize macrophages toward the M1 phenotype and activate immune responses to induce Interferon-beta (IFN-beta) production in vesicular stomatitis virus (VSV)-infected macrophages.	Metals	35-40	glutathione S-transferase pi 1	Homo sapiens	74-79
33326171-0	2021	GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer.	Carboplatin	79-90	glutathione S-transferase pi 1	Homo sapiens	0-5
33725933-0	2021	Evaluating the role of GSTP1 genetic polymorphism (rs1695, 313A>G) as a predictor in cyclophosphamide-induced toxicities.	Cyclophosphamide	85-101	glutathione S-transferase pi 1	Homo sapiens	23-28
33725933-1	2021	ABSTRACT: The association between Glutathione S-transferase Pi 1(GSTP1) genetic polymorphism (rs1695, 313A>G) and cyclophosphamide-induced toxicities has been widely investigated in previous studies, however, the results were inconsistent.	Cyclophosphamide	114-130	glutathione S-transferase pi 1	Homo sapiens	34-64
33725933-1	2021	ABSTRACT: The association between Glutathione S-transferase Pi 1(GSTP1) genetic polymorphism (rs1695, 313A>G) and cyclophosphamide-induced toxicities has been widely investigated in previous studies, however, the results were inconsistent.	Cyclophosphamide	114-130	glutathione S-transferase pi 1	Homo sapiens	65-70
33725933-3	2021	Risk ratios (RRs) and 95% confidence intervals (95% CIs) were used to estimate the association between GSTP1 rs1695 polymorphism and cyclophosphamide-induced hemotoxicity, gastrointestinal toxicity, infection, and neurotoxicity.A total of 13 studies were eventually included.	Cyclophosphamide	133-149	glutathione S-transferase pi 1	Homo sapiens	103-108
33725933-4	2021	Compared with the GSTP1 rs1695 AA genotype carriers, patients with AG and GG genotypes had an increased risk of cyclophosphamide-induced gastrointestinal toxicity (RR, 1.61; 95% CI, 1.18-2.19; P = .003) and infection (RR, 1.57; 95% CI, 1.00-2.48; P = .05) in the overall population.	Cyclophosphamide	112-128	glutathione S-transferase pi 1	Homo sapiens	18-23
33725933-5	2021	In the subgroup analyses, there were significant associations between GSTP1 rs1695 polymorphism and the risk of cyclophosphamide-induced myelosuppression (RR, 2.10; 95% CI, 1.60-2.76; P < .00001), gastrointestinal toxicity (RR, 1.77; 95%CI, 1.25-2.53; P = .001), and infection (RR, 2.01; 95% CI, 1.14-3.54; P = .02) in systemic lupus erythematosus (SLE) or lupus nephritis syndrome patients, but not in cancer patients.Our results confirmed an essential role for the GSTP1 rs1695 polymorphism in the prediction of cyclophosphamide-induced myelosuppression, gastrointestinal toxicity, and infection in SLE or lupus nephritis syndrome patients.	Cyclophosphamide	112-128	glutathione S-transferase pi 1	Homo sapiens	70-75
33725933-5	2021	In the subgroup analyses, there were significant associations between GSTP1 rs1695 polymorphism and the risk of cyclophosphamide-induced myelosuppression (RR, 2.10; 95% CI, 1.60-2.76; P < .00001), gastrointestinal toxicity (RR, 1.77; 95%CI, 1.25-2.53; P = .001), and infection (RR, 2.01; 95% CI, 1.14-3.54; P = .02) in systemic lupus erythematosus (SLE) or lupus nephritis syndrome patients, but not in cancer patients.Our results confirmed an essential role for the GSTP1 rs1695 polymorphism in the prediction of cyclophosphamide-induced myelosuppression, gastrointestinal toxicity, and infection in SLE or lupus nephritis syndrome patients.	Cyclophosphamide	112-128	glutathione S-transferase pi 1	Homo sapiens	467-472
33388378-0	2021	TET-mediated DNA demethylation plays an important role in arsenic-induced HBE cells oxidative stress via regulating promoter methylation of OGG1 and GSTP1.	tetramethylenedisulfotetramine	0-3	glutathione S-transferase pi 1	Homo sapiens	149-154
33388378-0	2021	TET-mediated DNA demethylation plays an important role in arsenic-induced HBE cells oxidative stress via regulating promoter methylation of OGG1 and GSTP1.	Arsenic	58-65	glutathione S-transferase pi 1	Homo sapiens	149-154
33388378-9	2021	Additionally, the TETs positively regulated the promoter methylation of the antioxidant genes 8-oxoguanine DNA glycosylase (OGG1) and glutathione S-transferase Pi 1 (GSTP1).	tetramethylenedisulfotetramine	18-22	glutathione S-transferase pi 1	Homo sapiens	134-164
33388378-9	2021	Additionally, the TETs positively regulated the promoter methylation of the antioxidant genes 8-oxoguanine DNA glycosylase (OGG1) and glutathione S-transferase Pi 1 (GSTP1).	tetramethylenedisulfotetramine	18-22	glutathione S-transferase pi 1	Homo sapiens	166-171
33388378-10	2021	Taken together, the results indicate that arsenic induced the inhibition of TET-mediated DNA demethylation, which induced promoter hypermethylation, inhibiting the expression of the OGG1 and GSTP1, and increasing oxidative stress in lung cells in vitro.	Arsenic	42-49	glutathione S-transferase pi 1	Homo sapiens	191-196
33388378-10	2021	Taken together, the results indicate that arsenic induced the inhibition of TET-mediated DNA demethylation, which induced promoter hypermethylation, inhibiting the expression of the OGG1 and GSTP1, and increasing oxidative stress in lung cells in vitro.	tetramethylenedisulfotetramine	76-79	glutathione S-transferase pi 1	Homo sapiens	191-196
33326171-0	2021	GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer.	Paclitaxel	95-105	glutathione S-transferase pi 1	Homo sapiens	0-5
33599104-10	2021	Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated the down-regulated expression of glutathione S-transferase P (GSTP1) in the glutathione metabolism signalling pathway in the POAG combined with cataract group.	Glutathione	99-110	glutathione S-transferase pi 1	Homo sapiens	128-133
33672092-6	2021	We summarize the association findings between drug hypersensitivity reactions and variants in the genes that encode the enzymes related to the redox system such as enzymes related to glutathione: Glutathione S-transferase (GSTM1, GSTP, GSTT1) and glutathione peroxidase (GPX1), thioredoxin reductase (TXNRD1 and TXNRD2), superoxide dismutase (SOD1, SOD2, and SOD3), catalase (CAT), aldo-keto reductase (AKR), and the peroxiredoxin system (PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, PRDX6).	Glutathione	183-194	glutathione S-transferase pi 1	Homo sapiens	230-234
33709282-3	2021	This study reports, the influence of GSTP1*B and GSTT1/GSTM1null polymorphisms in response to imatinib in CML patients in a Brazilian population.	Imatinib Mesylate	94-102	glutathione S-transferase pi 1	Homo sapiens	37-42
33709282-11	2021	The "G allele" of GSTP1*B, is associated with later cytogenetic response in imatinib therapy.	Imatinib Mesylate	76-84	glutathione S-transferase pi 1	Homo sapiens	18-23
33529017-2	2021	In this work, a series of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) derivatives as GST P1-1 inhibitors were designed, synthesized, and evaluated for their biological activity.	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	26-73	glutathione S-transferase pi 1	Homo sapiens	98-106
33529017-2	2021	In this work, a series of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) derivatives as GST P1-1 inhibitors were designed, synthesized, and evaluated for their biological activity.	6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol	75-81	glutathione S-transferase pi 1	Homo sapiens	98-106
33546147-0	2021	Associations of Metabolic Genes (GSTT1, GSTP1, GSTM1) and Blood Mercury Concentrations Differ in Jamaican Children with and without Autism Spectrum Disorder.	Mercury	64-71	glutathione S-transferase pi 1	Homo sapiens	40-45
33544514-10	2021	This study also revealed a protective effect of the interaction between GSTP1 rs1695 polymorphism and asbestos exposure on MM risk.	Asbestos	102-110	glutathione S-transferase pi 1	Homo sapiens	72-77
32964640-5	2021	The GSH-Lac-alkyne selectively probes the glutathione S-transferase P responsible for multidrug resistance.	gsh-lac-alkyne	4-18	glutathione S-transferase pi 1	Homo sapiens	42-69
33064289-0	2021	R-sulforaphane modulates the expression profile of AhR, ERalpha, Nrf2, NQO1, and GSTP in human breast cell lines.	sulforaphane	0-14	glutathione S-transferase pi 1	Homo sapiens	81-85
33264651-0	2021	Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes SOD2 and GSTP1 genes and SLE risk and severity in an Egyptian pediatric population.	single-nucleotide	0-17	glutathione S-transferase pi 1	Homo sapiens	71-76
33280607-0	2020	Predictive value of clinical toxicities of chemotherapy with fluoropyrimidines and oxaliplatin in colorectal cancer by DPYD and GSTP1 gene polymorphisms.	fluoropyrimidines	61-78	glutathione S-transferase pi 1	Homo sapiens	128-133
32767141-0	2021	Development of Telintra as an Inhibitor of Glutathione S-Transferase P.	gamma-Glu-S-BzCys-PhGly diethyl ester	15-23	glutathione S-transferase pi 1	Homo sapiens	43-70
32767141-4	2021	Preclinical and clinical testing of a nanomolar inhibitor of GSTP, TLK199 (Telintra; Ezatiostat) has indicated a role for the enzyme in hematopoiesis and utility for the drug in the treatment of patients with myelodysplastic syndrome.	gamma-Glu-S-BzCys-PhGly diethyl ester	67-73	glutathione S-transferase pi 1	Homo sapiens	61-65
33280607-0	2020	Predictive value of clinical toxicities of chemotherapy with fluoropyrimidines and oxaliplatin in colorectal cancer by DPYD and GSTP1 gene polymorphisms.	Oxaliplatin	83-94	glutathione S-transferase pi 1	Homo sapiens	128-133
32289338-9	2020	Increased acetaminophen use was associated with asthma at 18 years for children with GSTP1 Ile/Ile (OR=1 66, 1 07, 2 57), but not other GSTP1 genotypes.	Acetaminophen	10-23	glutathione S-transferase pi 1	Homo sapiens	85-90
32937189-9	2020	Preventing S-glutathionylation in MM cells with a GSTP specific inhibitor restored BiP activities and reversed resistance to Btz.	Bortezomib	125-128	glutathione S-transferase pi 1	Homo sapiens	50-54
32937189-11	2020	We conclude that altered GSTP expression leads to S-glutathionylation of BiP, and contributes to acquired resistance to Btz in MM.	Bortezomib	120-123	glutathione S-transferase pi 1	Homo sapiens	25-29
33215267-2	2020	Glutathione S-transferase Pi (GSTP1-1) catalyzes the conjugation of glutathione with anticancer drugs and therefore reduces their efficacy.	Glutathione	0-11	glutathione S-transferase pi 1	Homo sapiens	30-37
33215267-2	2020	Glutathione S-transferase Pi (GSTP1-1) catalyzes the conjugation of glutathione with anticancer drugs and therefore reduces their efficacy.	Glutathione	68-79	glutathione S-transferase pi 1	Homo sapiens	30-37
33215267-7	2020	The n-butanol fraction was the most effective in inhibiting eGST, hGSTP1-1, and pGST with IC50 values of 3.0 +- 0.7, 4.85 +- 0.35, and 6.6 +- 1.2 mug/ml, respectively.	1-Butanol	4-13	glutathione S-transferase pi 1	Homo sapiens	66-74
33196414-8	2021	The plasma concentration of TBARS was associated with GSTP1 303AG/GG, GSTP1 -16CT/TT, and SOD2 47CT/TT genotypes.	Thiobarbituric Acid Reactive Substances	28-33	glutathione S-transferase pi 1	Homo sapiens	54-59
33196414-8	2021	The plasma concentration of TBARS was associated with GSTP1 303AG/GG, GSTP1 -16CT/TT, and SOD2 47CT/TT genotypes.	Thiobarbituric Acid Reactive Substances	28-33	glutathione S-transferase pi 1	Homo sapiens	70-75
33196414-12	2021	We observed an association between elevated TBARS levels and the presence of GSTP1 and SOD2 variants in stored RBC.	Thiobarbituric Acid Reactive Substances	44-49	glutathione S-transferase pi 1	Homo sapiens	77-82
33080187-3	2020	Although GSTP1 exists in TAMs, whether GSTP1 in TAMs promotes drug resistance is still unclear.	tams	25-29	glutathione S-transferase pi 1	Homo sapiens	9-14
33080187-3	2020	Although GSTP1 exists in TAMs, whether GSTP1 in TAMs promotes drug resistance is still unclear.	tams	48-52	glutathione S-transferase pi 1	Homo sapiens	39-44
33080187-5	2020	GSTP1 is aberrantly expressed in TAMs from breast cancer tissues of patients after chemotherapy than that without chemotherapy.	tams	33-37	glutathione S-transferase pi 1	Homo sapiens	0-5
33080187-6	2020	Adriamycin (ADR) time-dependently induced the expression of GSTP1 in TAMs in vitro.	Doxorubicin	0-10	glutathione S-transferase pi 1	Homo sapiens	60-65
33080187-8	2020	Meanwhile, overexpression of GSTP1 in TAMs promoted the expression and release of interleukin-6 (IL-6) associated with reduced ADR-induced breast cell death, which was reversed by IL-6 antibody.	tams	38-42	glutathione S-transferase pi 1	Homo sapiens	29-34
33035787-7	2020	In the oxaliplatin group, rs1045642 TT genotype was associated with the need to adjust treatment (OR = 0.32; p = 0.02), ERCC1 rs11615 GG genotype with asthenia (OR = 3.01; p = 0.01) and rs1615 GSTP1 GG genotype with respiratory toxicity (OR = 5.07; p = 0.009).	Oxaliplatin	7-18	glutathione S-transferase pi 1	Homo sapiens	193-198
32524749-7	2020	We also showed that ethanol, LPS and DEN synergistically induced liver structural disarrangement, steatosis and inflammatory infiltration accompanied by increased levels of proliferation (Ki67), ethanol metabolism (CYP2E1), hepatocarcinogenesis (GSTP1), and LPS-inducible (MYD88 and TLR4) markers.	Ethanol	20-27	glutathione S-transferase pi 1	Homo sapiens	246-251
32524749-7	2020	We also showed that ethanol, LPS and DEN synergistically induced liver structural disarrangement, steatosis and inflammatory infiltration accompanied by increased levels of proliferation (Ki67), ethanol metabolism (CYP2E1), hepatocarcinogenesis (GSTP1), and LPS-inducible (MYD88 and TLR4) markers.	Diethylnitrosamine	37-40	glutathione S-transferase pi 1	Homo sapiens	246-251
33006026-2	2020	Glutathione S-transferase Pi (GSTP1) is reported to detoxify the xenobiotic substrates by catalyzing their conjugation to reduced glutathione (GSH) and its over-expression was demonstrated in the early stages of HCC, while loss of GSTP1 has been suggested to increase the risk of deoxyribonucleic acid (DNA) damage and mutation.	Glutathione	0-11	glutathione S-transferase pi 1	Homo sapiens	30-35
33193808-0	2020	Interaction between a Mixture of Heavy Metals (Lead, Mercury, Arsenic, Cadmium, Manganese, Aluminum) and GSTP1, GSTT1, and GSTM1 in Relation to Autism Spectrum Disorder.	Mercury	53-60	glutathione S-transferase pi 1	Homo sapiens	105-110
33193808-5	2020	In an unadjusted negative gWQS model, we found a marginally significant interaction between GSTP1 and a mixture of three metals (Pb, Hg, and Mn) (P = 0.07) while the association was no longer significant after adjustment for the same covariates (P = 0.24).	Lead	129-131	glutathione S-transferase pi 1	Homo sapiens	92-97
33193808-5	2020	In an unadjusted negative gWQS model, we found a marginally significant interaction between GSTP1 and a mixture of three metals (Pb, Hg, and Mn) (P = 0.07) while the association was no longer significant after adjustment for the same covariates (P = 0.24).	Mercury	133-135	glutathione S-transferase pi 1	Homo sapiens	92-97
33036340-8	2020	As the result of iTRAQ proteomic analysis, calmodulin-like protein 3, glutathione S-transferase P, and keratin type I cytoskeletal 13 increased characteristically in patient taking calcium blocker, and the expression in calmodulin-like protein 3 was significantly larger (p < 0.01).	Calcium	181-188	glutathione S-transferase pi 1	Homo sapiens	70-133
33087132-3	2020	NQO1 and GSTP1 decrease the formation of reactive oxygen species (ROS), which mediates the oxidative stress and promotes GBM cell proliferation.	Reactive Oxygen Species	41-64	glutathione S-transferase pi 1	Homo sapiens	9-14
33087132-3	2020	NQO1 and GSTP1 decrease the formation of reactive oxygen species (ROS), which mediates the oxidative stress and promotes GBM cell proliferation.	Reactive Oxygen Species	66-69	glutathione S-transferase pi 1	Homo sapiens	9-14
33006026-2	2020	Glutathione S-transferase Pi (GSTP1) is reported to detoxify the xenobiotic substrates by catalyzing their conjugation to reduced glutathione (GSH) and its over-expression was demonstrated in the early stages of HCC, while loss of GSTP1 has been suggested to increase the risk of deoxyribonucleic acid (DNA) damage and mutation.	Glutathione	0-11	glutathione S-transferase pi 1	Homo sapiens	231-236
33006026-2	2020	Glutathione S-transferase Pi (GSTP1) is reported to detoxify the xenobiotic substrates by catalyzing their conjugation to reduced glutathione (GSH) and its over-expression was demonstrated in the early stages of HCC, while loss of GSTP1 has been suggested to increase the risk of deoxyribonucleic acid (DNA) damage and mutation.	Glutathione	130-141	glutathione S-transferase pi 1	Homo sapiens	30-35
33006026-2	2020	Glutathione S-transferase Pi (GSTP1) is reported to detoxify the xenobiotic substrates by catalyzing their conjugation to reduced glutathione (GSH) and its over-expression was demonstrated in the early stages of HCC, while loss of GSTP1 has been suggested to increase the risk of deoxyribonucleic acid (DNA) damage and mutation.	Glutathione	130-141	glutathione S-transferase pi 1	Homo sapiens	231-236
33006026-2	2020	Glutathione S-transferase Pi (GSTP1) is reported to detoxify the xenobiotic substrates by catalyzing their conjugation to reduced glutathione (GSH) and its over-expression was demonstrated in the early stages of HCC, while loss of GSTP1 has been suggested to increase the risk of deoxyribonucleic acid (DNA) damage and mutation.	Glutathione	143-146	glutathione S-transferase pi 1	Homo sapiens	30-35
33006026-2	2020	Glutathione S-transferase Pi (GSTP1) is reported to detoxify the xenobiotic substrates by catalyzing their conjugation to reduced glutathione (GSH) and its over-expression was demonstrated in the early stages of HCC, while loss of GSTP1 has been suggested to increase the risk of deoxyribonucleic acid (DNA) damage and mutation.	Glutathione	143-146	glutathione S-transferase pi 1	Homo sapiens	231-236
32918123-9	2020	To our knowledge, the current study is the first to investigate the relationship between CYP2D6*4 and GSTP1 Ile105Val polymorphisms and the risk of developing MPNs in the Turkish population.	ile105val	108-117	glutathione S-transferase pi 1	Homo sapiens	102-107
32488710-3	2020	Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure.	Polycyclic Aromatic Hydrocarbons	40-43	glutathione S-transferase pi 1	Homo sapiens	105-110
32787104-2	2020	Unlike monofunctional CDDO-Me, the bifunctional analog, CDDO-Im, has a second reactive site (imidazolide) and can covalently bind to amino acids other than cysteine on target proteins such as glutathione S-transferase pi (GSTP), serum albumin, or Keap1.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	56-63	glutathione S-transferase pi 1	Homo sapiens	192-220
32787104-2	2020	Unlike monofunctional CDDO-Me, the bifunctional analog, CDDO-Im, has a second reactive site (imidazolide) and can covalently bind to amino acids other than cysteine on target proteins such as glutathione S-transferase pi (GSTP), serum albumin, or Keap1.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	56-63	glutathione S-transferase pi 1	Homo sapiens	222-226
32787104-3	2020	Here we show for the first time that bifunctional CDDO-Im (in contrast to CDDO-Me), as low as 50 nM, can covalently transacylate arginine and serine residues in GSTP and cross link them to adjacent cysteine residues.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	50-57	glutathione S-transferase pi 1	Homo sapiens	161-165
32787104-3	2020	Here we show for the first time that bifunctional CDDO-Im (in contrast to CDDO-Me), as low as 50 nM, can covalently transacylate arginine and serine residues in GSTP and cross link them to adjacent cysteine residues.	Arginine	129-137	glutathione S-transferase pi 1	Homo sapiens	161-165
32787104-3	2020	Here we show for the first time that bifunctional CDDO-Im (in contrast to CDDO-Me), as low as 50 nM, can covalently transacylate arginine and serine residues in GSTP and cross link them to adjacent cysteine residues.	Serine	142-148	glutathione S-transferase pi 1	Homo sapiens	161-165
32488710-3	2020	Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure.	Glutathione	70-81	glutathione S-transferase pi 1	Homo sapiens	105-110
32488710-3	2020	Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure.	Glutathione	135-146	glutathione S-transferase pi 1	Homo sapiens	105-110
32488710-3	2020	Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure.	Polycyclic Aromatic Hydrocarbons	150-153	glutathione S-transferase pi 1	Homo sapiens	105-110
32897019-3	2020	AIM: to establish the association of two polymorphic loci Ile105Val, Ala114Val of the GSTP1 gene (glutathione transferase class pi-1) with the parameters of oxidative stress in men with infertility.	ile105val	58-67	glutathione S-transferase pi 1	Homo sapiens	86-91
32880833-0	2020	Genetic polymorphisms of GSTP1, XRCC1, XPC and ERCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer patients of Bangladesh.	Platinum	88-96	glutathione S-transferase pi 1	Homo sapiens	25-30
32880833-6	2020	Although GSTP1 (rs1695) polymorphism might serve as prognostic factor regarding grade 3 or 4 neutropenia, a significant (p = 0.044) improvement in response to platinum-based chemotherapy was observed.	Platinum	159-167	glutathione S-transferase pi 1	Homo sapiens	9-14
32880833-8	2020	XRCC1 (rs2228001) and GSTP1 (rs1695) polymorphisms might explain platinum-induced clinical outcomes in terms of both toxicity and therapeutic response variations among Bangladeshi advanced NSCLC patients.	Platinum	65-73	glutathione S-transferase pi 1	Homo sapiens	22-27
32535103-0	2020	0FF0DTargeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.	Paclitaxel	29-39	glutathione S-transferase pi 1	Homo sapiens	84-89
32473836-0	2020	Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment.	Water	20-25	glutathione S-transferase pi 1	Homo sapiens	70-77
32473836-0	2020	Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment.	Esters	34-40	glutathione S-transferase pi 1	Homo sapiens	70-77
32473836-0	2020	Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment.	nitrobenzoxadiazole	44-63	glutathione S-transferase pi 1	Homo sapiens	70-77
32473836-6	2020	Interestingly, esters 3-5 displayed high inhibitory activity towards the glutathione transferase (GST) isoform GSTP1-1 and showed a reactivity towards reduced glutathione comparable to that of the respective parent compound.	Esters	15-21	glutathione S-transferase pi 1	Homo sapiens	111-118
32535103-8	2020	We further identified that G6PD promotes paclitaxel resistance by regulating the expression of glutathione S-transferase P1 (GSTP1), which confers resistance to chemotherapy by detoxifying several anticancer drugs.	Paclitaxel	41-51	glutathione S-transferase pi 1	Homo sapiens	95-123
32535103-8	2020	We further identified that G6PD promotes paclitaxel resistance by regulating the expression of glutathione S-transferase P1 (GSTP1), which confers resistance to chemotherapy by detoxifying several anticancer drugs.	Paclitaxel	41-51	glutathione S-transferase pi 1	Homo sapiens	125-130
32711417-0	2020	ERCC1, XRCC1, and GSTP1 Polymorphisms and Treatment Outcomes of Advanced Epithelial Ovarian Cancer Patients Treated with Platinum-based Chemotherapy.	Platinum	121-129	glutathione S-transferase pi 1	Homo sapiens	18-23
32650499-13	2020	Interactions between polymorphic variants As3MT*GSTM1 and GSTO2*GSTP1 could be potential modifiers of urinary excretion of arsenic and covariates as age, LADD, and alcohol consumption contribute to largely vary the arsenic individual metabolic capacity in exposed people.	Alcohols	164-171	glutathione S-transferase pi 1	Homo sapiens	64-69
32650499-13	2020	Interactions between polymorphic variants As3MT*GSTM1 and GSTO2*GSTP1 could be potential modifiers of urinary excretion of arsenic and covariates as age, LADD, and alcohol consumption contribute to largely vary the arsenic individual metabolic capacity in exposed people.	Arsenic	215-222	glutathione S-transferase pi 1	Homo sapiens	64-69
32751086-5	2020	Moreover, serum vitamin C level also is dependent on genetic factors, such as SLC23A1 and SLC23A2 genes, encoding sodium-dependent vitamin C transporters and GSTM1, GSTP1 and GSTT1 genes which encode glutathione S-transferases.	Ascorbic Acid	16-25	glutathione S-transferase pi 1	Homo sapiens	165-170
32650499-10	2020	Besides, DMA concentrations were lower in heterozygous and/or homozygous genotypes of GSTP1 compared to the wild-type genotype.	Cacodylic Acid	9-12	glutathione S-transferase pi 1	Homo sapiens	86-91
32650499-13	2020	Interactions between polymorphic variants As3MT*GSTM1 and GSTO2*GSTP1 could be potential modifiers of urinary excretion of arsenic and covariates as age, LADD, and alcohol consumption contribute to largely vary the arsenic individual metabolic capacity in exposed people.	Arsenic	123-130	glutathione S-transferase pi 1	Homo sapiens	64-69
32711417-3	2020	Methods: We conducted the study to investigate the association between polymorphisms of ERCC1, XRCC1 and GSTP1, which responsible for platinum"s metabolisms in Thai epithelial ovarian cancer patients.	Platinum	134-142	glutathione S-transferase pi 1	Homo sapiens	105-110
32711417-9	2020	CONCLUSIONS: Genetic polymorphisms of ERCC1, and GSTP1 might be useful biomarkers for prediction of clinical benefit and toxicities of platinum-based chemotherapy in Thai epithelial ovarian cancer patients.<br />.	Platinum	135-143	glutathione S-transferase pi 1	Homo sapiens	49-54
32070777-5	2020	The combination of XAN and PEITC also enhanced the activation and expression of Nrf2 and subsequently the expression of GSTP, NQO1, and SOD genes which are controlled by this transcription factor.	xanthohumol	19-22	glutathione S-transferase pi 1	Homo sapiens	120-124
32128658-6	2020	However, inhibition of autophagy by 3-methyladenine or chloroquine significantly reduced the anti-inflammatory effect of GSTP1.	3-methyladenine	36-51	glutathione S-transferase pi 1	Homo sapiens	121-126
32128658-6	2020	However, inhibition of autophagy by 3-methyladenine or chloroquine significantly reduced the anti-inflammatory effect of GSTP1.	Chloroquine	55-66	glutathione S-transferase pi 1	Homo sapiens	121-126
32526700-3	2020	Here we show that C/EBPbeta, a ROS responsive transcription factor, regulates the transcription of NQO1 and GSTP1, two antioxidative reductases, which neutralize ROS in the GBM and mediates their proliferation.	ros	31-34	glutathione S-transferase pi 1	Homo sapiens	108-113
32526700-3	2020	Here we show that C/EBPbeta, a ROS responsive transcription factor, regulates the transcription of NQO1 and GSTP1, two antioxidative reductases, which neutralize ROS in the GBM and mediates their proliferation.	ros	162-165	glutathione S-transferase pi 1	Homo sapiens	108-113
32543462-10	2020	However, heterozygote genotypes (Gln-Arg and Ile-Val) in XRCC1 and GSTP1 genes, respectively, were associated with LINE-1 hypermethylation among UE compared with other corresponding genotypes.	Glutamine	33-36	glutathione S-transferase pi 1	Homo sapiens	67-72
32543462-10	2020	However, heterozygote genotypes (Gln-Arg and Ile-Val) in XRCC1 and GSTP1 genes, respectively, were associated with LINE-1 hypermethylation among UE compared with other corresponding genotypes.	Arginine	37-40	glutathione S-transferase pi 1	Homo sapiens	67-72
32070777-5	2020	The combination of XAN and PEITC also enhanced the activation and expression of Nrf2 and subsequently the expression of GSTP, NQO1, and SOD genes which are controlled by this transcription factor.	phenethyl isothiocyanate	27-32	glutathione S-transferase pi 1	Homo sapiens	120-124
32176468-5	2020	Method performance was evaluated by trapping acetaminophen reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) with human glutathione S-transferase pi (hGSTP), human serum albumin (HSA), and bovine serum albumin (BSA) as model target proteins.	Acetaminophen	45-58	glutathione S-transferase pi 1	Homo sapiens	157-162
32176468-5	2020	Method performance was evaluated by trapping acetaminophen reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) with human glutathione S-transferase pi (hGSTP), human serum albumin (HSA), and bovine serum albumin (BSA) as model target proteins.	N-acetyl-4-benzoquinoneimine	79-107	glutathione S-transferase pi 1	Homo sapiens	157-162
32176468-5	2020	Method performance was evaluated by trapping acetaminophen reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) with human glutathione S-transferase pi (hGSTP), human serum albumin (HSA), and bovine serum albumin (BSA) as model target proteins.	N-acetyl-4-benzoquinoneimine	109-114	glutathione S-transferase pi 1	Homo sapiens	157-162
32176468-7	2020	Human liver microsomes and CYP1A2 supersomes showed the highest bioactivation rate for adduct formation, in which all four cysteines of hGSTP reacted with NAPQI.	Cysteine	123-132	glutathione S-transferase pi 1	Homo sapiens	136-141
32231024-0	2020	Genetic Polymorphism of GSTP-1 Affects Cyclophosphamide Treatment of Autoimmune Diseases.	Cyclophosphamide	39-55	glutathione S-transferase pi 1	Homo sapiens	24-30
32231024-6	2020	It was found that the GSTP1 I105V allelic variation significantly associated with the cyclophosphamide treatment-dependent disease-remissions.	Cyclophosphamide	86-102	glutathione S-transferase pi 1	Homo sapiens	22-27
32231024-9	2020	Since this variant of GSTP1 can be characterized by lower conjugation capacity that results in an elongated and higher therapeutic dose of cyclophosphamide, our data suggest that the decreased activity of this variant of GSTP1 can be in the background of the more effective disease treatment.	Cyclophosphamide	139-155	glutathione S-transferase pi 1	Homo sapiens	22-27
32231024-9	2020	Since this variant of GSTP1 can be characterized by lower conjugation capacity that results in an elongated and higher therapeutic dose of cyclophosphamide, our data suggest that the decreased activity of this variant of GSTP1 can be in the background of the more effective disease treatment.	Cyclophosphamide	139-155	glutathione S-transferase pi 1	Homo sapiens	221-226
31834435-1	2020	PURPOSE: This study aimed to develop a population pharmacokinetic (PPK) model to investigate the impact of GSTA1, GSTP1, and GSTM1 genotypes on busulfan pharmacokinetic (PK) variability in Chinese adult patients.	Busulfan	144-152	glutathione S-transferase pi 1	Homo sapiens	114-119
32183092-1	2020	Background and Objectives: One of the most frequent genetic alterations reported to date in prostate cancer (PC) is aberrant methylation of glutathione transferase P1 (GSTP1).	Glutathione	140-151	glutathione S-transferase pi 1	Homo sapiens	168-173
32183092-7	2020	Conclusion: Prostate cancer may be influenced by multiple glutathione transferase (GST) polymorphic genes, especially GSTP1, highlighting the role of gene-gene interactions in human susceptibility to this cancer.	Glutathione	58-69	glutathione S-transferase pi 1	Homo sapiens	118-123
32363837-9	2020	The GSTP1 heterozygote genotype, which could affect the metabolism of benzene detoxification, was found in both groups but was more frequent in those occupationally exposed.	Benzene	70-77	glutathione S-transferase pi 1	Homo sapiens	4-9
32034669-6	2020	Expression of antioxidant genes such as glutathione S-transferase P1 and superoxide dismutase-2 were found to be upregulated with plumbagin treatment in A549 cells.	plumbagin	130-139	glutathione S-transferase pi 1	Homo sapiens	40-68
32713331-4	2020	METHODS: In the present work, the interaction of COL and its derivative 2,3-didemethylcolchicine (2,3-DDCOL) with human glutathione transferases (hGSTA1-1, hGSTP1-1, GSTM1-1) was investigated by inhibition analysis, molecular modelling and molecular dynamics simulations.	2,3-didemethylcolchicine	72-96	glutathione S-transferase pi 1	Homo sapiens	156-164
31886888-5	2020	The main aim of the current study was to compare the frequency of SNP polymorphisms in XRCC1 (rs7997782) and GSTP1 (rs1695) genes involved in DNA repair of single strand breaks (SSB) and xenobiotic detoxification between alcohol addicts and a control group comprised of non-drinkers.	Alcohols	221-228	glutathione S-transferase pi 1	Homo sapiens	109-114
31736447-9	2020	Altered expressions of nine proteins (ACTG, PROF1, PPIA, PDIA3, COF1, GSTP1, ALDOA, TBA1C and TBB5) were considered for combined drug actions of oxaliplatin with patulin.	oxaliplatin	145-156	glutathione S-transferase pi 1	Homo sapiens	70-75
32713331-4	2020	METHODS: In the present work, the interaction of COL and its derivative 2,3-didemethylcolchicine (2,3-DDCOL) with human glutathione transferases (hGSTA1-1, hGSTP1-1, GSTM1-1) was investigated by inhibition analysis, molecular modelling and molecular dynamics simulations.	2,3-didemethylcolchicine	98-107	glutathione S-transferase pi 1	Homo sapiens	156-164
32713331-4	2020	METHODS: In the present work, the interaction of COL and its derivative 2,3-didemethylcolchicine (2,3-DDCOL) with human glutathione transferases (hGSTA1-1, hGSTP1-1, GSTM1-1) was investigated by inhibition analysis, molecular modelling and molecular dynamics simulations.	Glutathione	120-131	glutathione S-transferase pi 1	Homo sapiens	156-164
31731000-7	2020	Moreover, the effects of OCPs exposure on HCC risk are more pronounced amongst GSTP1 (Ile/Val + Val/Val) and GSTP1 promoter methylation subjects than those who were GSTP1 (Ile/Ile) and unmethylated subjects.	valsartan	90-93	glutathione S-transferase pi 1	Homo sapiens	79-84
31905195-9	2020	The distribution of Val/Val genotype of the GSTP1 rs1695 gene polymorphism had a higher incidence in healthy workers compared with patients with toxic liver damage (p=0.036).	Valine	20-23	glutathione S-transferase pi 1	Homo sapiens	44-49
32071492-0	2020	Glutathione S-Transferase P1 313 (A > G) Ile105Val Polymorphism Contributes to Cancer Susceptibility in Indian Population: A Meta-analysis of 39 Case-Control Studies.	ile105val	41-50	glutathione S-transferase pi 1	Homo sapiens	0-28
32337014-9	2020	The result of qRT-PCR indicated that 5-Aza-CdR decreased DNMT1, DNMT3a, DNMT3b and increased GSTP1and SOCS1 genes expression and SAHA decreased HDAC1 and increased GSTP1 and SOCS1 genes expression significantly.	Decitabine	37-46	glutathione S-transferase pi 1	Homo sapiens	93-98
32337014-9	2020	The result of qRT-PCR indicated that 5-Aza-CdR decreased DNMT1, DNMT3a, DNMT3b and increased GSTP1and SOCS1 genes expression and SAHA decreased HDAC1 and increased GSTP1 and SOCS1 genes expression significantly.	Decitabine	37-46	glutathione S-transferase pi 1	Homo sapiens	164-169
32337014-11	2020	Conclusion: 5-AZA-CdR and SAHA down-regulated DNMT1, DNMT3a, DNMT3b, and HDAC1 and up-regulated GSTP1 and SOCS1 gene expression by which inhibited cell viability and induced apoptosis, suggesting that they could be used in the treatment of HCC.	Vorinostat	26-30	glutathione S-transferase pi 1	Homo sapiens	96-101
31905195-9	2020	The distribution of Val/Val genotype of the GSTP1 rs1695 gene polymorphism had a higher incidence in healthy workers compared with patients with toxic liver damage (p=0.036).	Valine	24-27	glutathione S-transferase pi 1	Homo sapiens	44-49
31243599-1	2019	Piperlongumine (PL) is an alkaloid that inhibits glutathione S-transferase pi 1 (GSTP1) activity, resulting in elevated reactive oxygen species (ROS) levels and cancer-selective cell death.	piperlonguminine	0-14	glutathione S-transferase pi 1	Homo sapiens	49-79
31169043-0	2019	Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis.	benzamide	40-49	glutathione S-transferase pi 1	Homo sapiens	86-93
31169043-0	2019	Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis.	nitrobenzoxadiazole	61-80	glutathione S-transferase pi 1	Homo sapiens	86-93
31169043-1	2019	The antitumor agent 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (1) is a potent inhibitor of GSTP1-1, a glutathione S-transferase capable of inhibiting apoptosis by binding to JNK1 and TRAF2.	6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio	20-65	glutathione S-transferase pi 1	Homo sapiens	106-113
31169043-1	2019	The antitumor agent 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (1) is a potent inhibitor of GSTP1-1, a glutathione S-transferase capable of inhibiting apoptosis by binding to JNK1 and TRAF2.	1-hexanol	66-76	glutathione S-transferase pi 1	Homo sapiens	106-113
31169043-2	2019	We recently demonstrated that, unlike its parent compound, the benzoyl ester of 1 (compound 3) exhibits negligible reactivity towards GSH, and has a different mode of interaction with GSTP1-1.	benzoyl ester	63-76	glutathione S-transferase pi 1	Homo sapiens	184-191
31611630-2	2019	In this study, we propose a promising strategy for cancer treatment using modulation of oxidative stress by suppression of glutathione S-transferases (GSTs), a typical antioxidant enzyme.	Glutathione	123-134	glutathione S-transferase pi 1	Homo sapiens	151-155
31611630-2	2019	In this study, we propose a promising strategy for cancer treatment using modulation of oxidative stress by suppression of glutathione S-transferases (GSTs), a typical antioxidant enzyme.	Sulfur	135-136	glutathione S-transferase pi 1	Homo sapiens	151-155
31637859-10	2019	Carriers of the GSTP1 Val variant allele had a greater than 2-fold increase in SSc risk (OR = 2.41; P = .0006).	Valine	22-25	glutathione S-transferase pi 1	Homo sapiens	16-21
31454540-7	2019	The pooling results indicated that GSTP1 gene 313 A/G (rs1695) polymorphism was obviously related to BCa (GG vs AA: OR = 1.33, 95%CI = 1.04-1.69).	alpha-bromocinnamaldehyde	101-104	glutathione S-transferase pi 1	Homo sapiens	35-40
31454540-11	2019	CONCLUSION: This study indicated that GSTP1 gene 313 A/G (rs1695) polymorphism increased the susceptibility to BCa, particularly to TCC.	alpha-bromocinnamaldehyde	111-114	glutathione S-transferase pi 1	Homo sapiens	38-43
31668063-6	2019	Flazin increased the expressions of Nrf2-dependent phase II enzyme genes and their products (NQO1, GSTP, and GSH proteins).	flazin	0-6	glutathione S-transferase pi 1	Homo sapiens	99-103
31243599-1	2019	Piperlongumine (PL) is an alkaloid that inhibits glutathione S-transferase pi 1 (GSTP1) activity, resulting in elevated reactive oxygen species (ROS) levels and cancer-selective cell death.	piperlonguminine	0-14	glutathione S-transferase pi 1	Homo sapiens	81-86
31243599-1	2019	Piperlongumine (PL) is an alkaloid that inhibits glutathione S-transferase pi 1 (GSTP1) activity, resulting in elevated reactive oxygen species (ROS) levels and cancer-selective cell death.	piperlonguminine	16-18	glutathione S-transferase pi 1	Homo sapiens	49-79
31243599-1	2019	Piperlongumine (PL) is an alkaloid that inhibits glutathione S-transferase pi 1 (GSTP1) activity, resulting in elevated reactive oxygen species (ROS) levels and cancer-selective cell death.	piperlonguminine	16-18	glutathione S-transferase pi 1	Homo sapiens	81-86
31243599-1	2019	Piperlongumine (PL) is an alkaloid that inhibits glutathione S-transferase pi 1 (GSTP1) activity, resulting in elevated reactive oxygen species (ROS) levels and cancer-selective cell death.	Reactive Oxygen Species	120-143	glutathione S-transferase pi 1	Homo sapiens	49-79
31243599-1	2019	Piperlongumine (PL) is an alkaloid that inhibits glutathione S-transferase pi 1 (GSTP1) activity, resulting in elevated reactive oxygen species (ROS) levels and cancer-selective cell death.	Reactive Oxygen Species	120-143	glutathione S-transferase pi 1	Homo sapiens	81-86
31243599-5	2019	Our results show PL causes dissociation of GSTP1 from JNK; robust JNK, c-Jun, and early ERK activation followed by suppression; increased expression of cleaved caspase-3 and cleaved PARP; and nuclear translocation of Nrf2 and c-Myc in PDAC cells.	piperlonguminine	17-19	glutathione S-transferase pi 1	Homo sapiens	43-48
30683915-3	2019	In the current study, we found a novel mechanism by which GSTP1 protects human breast cancer cells from adriamycin (ADR)-induced cell death and contributes to the drug resistance.	Doxorubicin	104-114	glutathione S-transferase pi 1	Homo sapiens	58-63
31653159-0	2019	Influence of DPYD*9A, DPYD*6 and GSTP1 ile105val Genetic Polymorphisms on Capecitabine and Oxaliplatin (CAPOX) Associated Toxicities in Colorectal Cancer (CRC) Patients.	capecitabine	74-86	glutathione S-transferase pi 1	Homo sapiens	33-38
30683915-9	2019	Proline123, leucine160, and glutamine163, which located in C terminal of GSTP1, are essential for GSTP1 to interact with p110alpha, and the following autophagy and drug resistance regulation.	proline123	0-10	glutathione S-transferase pi 1	Homo sapiens	73-78
30683915-9	2019	Proline123, leucine160, and glutamine163, which located in C terminal of GSTP1, are essential for GSTP1 to interact with p110alpha, and the following autophagy and drug resistance regulation.	proline123	0-10	glutathione S-transferase pi 1	Homo sapiens	98-103
30683915-9	2019	Proline123, leucine160, and glutamine163, which located in C terminal of GSTP1, are essential for GSTP1 to interact with p110alpha, and the following autophagy and drug resistance regulation.	leucine160	12-22	glutathione S-transferase pi 1	Homo sapiens	73-78
30683915-9	2019	Proline123, leucine160, and glutamine163, which located in C terminal of GSTP1, are essential for GSTP1 to interact with p110alpha, and the following autophagy and drug resistance regulation.	leucine160	12-22	glutathione S-transferase pi 1	Homo sapiens	98-103
30683915-9	2019	Proline123, leucine160, and glutamine163, which located in C terminal of GSTP1, are essential for GSTP1 to interact with p110alpha, and the following autophagy and drug resistance regulation.	glutamine163	28-40	glutathione S-transferase pi 1	Homo sapiens	73-78
30683915-9	2019	Proline123, leucine160, and glutamine163, which located in C terminal of GSTP1, are essential for GSTP1 to interact with p110alpha, and the following autophagy and drug resistance regulation.	glutamine163	28-40	glutathione S-transferase pi 1	Homo sapiens	98-103
31575956-7	2019	Antioxidant enzymes transcriptionally regulated by Nrf2 and involved in GSH, NADPH, and NADH generation were significantly lower including PRX1 and PRX3, GPX4, GSTP1, GCLC, and MTHFD2.	NAD	88-92	glutathione S-transferase pi 1	Homo sapiens	160-165
31575956-7	2019	Antioxidant enzymes transcriptionally regulated by Nrf2 and involved in GSH, NADPH, and NADH generation were significantly lower including PRX1 and PRX3, GPX4, GSTP1, GCLC, and MTHFD2.	Glutathione	72-75	glutathione S-transferase pi 1	Homo sapiens	160-165
31564855-8	2019	More important, the genotypes, AG, GG of GSTP1 exon5 and L/M*S, L/L of HO-1 (GT)n associated with increased 8-iso-prostaglandin F (2 alpha) (8-iso-PGF2) and malondialdehyde (MDA) concentration and decreased catalase (CAT) activity.	8-isoprostaglandin A2	108-129	glutathione S-transferase pi 1	Homo sapiens	41-46
31564855-8	2019	More important, the genotypes, AG, GG of GSTP1 exon5 and L/M*S, L/L of HO-1 (GT)n associated with increased 8-iso-prostaglandin F (2 alpha) (8-iso-PGF2) and malondialdehyde (MDA) concentration and decreased catalase (CAT) activity.	8-epi-prostaglandin F2alpha	141-151	glutathione S-transferase pi 1	Homo sapiens	41-46
30466891-2	2019	Detection of serum free methylated GSTP1 (mGSTP1) DNA is associated with overall survival (OS) and response to docetaxel in metastatic castration-resistant prostate cancer (mCRPC) in test and internal validation cohorts.	Docetaxel	111-120	glutathione S-transferase pi 1	Homo sapiens	35-40
31085226-10	2019	T. chamaedrys methanol extract inhibits mRNA expression of CYP1A1, CYP1B1, GSTP1, MRP1 and MRP2 in SW480 cells.	Methanol	14-22	glutathione S-transferase pi 1	Homo sapiens	75-80
31602266-4	2019	24%, 46%, 40%, 5%, and 44% GC had a potentially platinum sensitive phenotype by SNP analyses of GSTP1, ERCC1 rs11615, ERCC1 rs3212986, ERCC2, and XRCC1, respectively.	Platinum	48-56	glutathione S-transferase pi 1	Homo sapiens	96-101
31457004-9	2019	Seven modified cysteine sites were confirmed, including Cys112 in GSTA1, Cys78 in GSTM1, Cys115 and 174 in GSTM2, as well as Cys15, 48, and 170 in GSTP1.	Cysteine	15-23	glutathione S-transferase pi 1	Homo sapiens	147-152
30973677-0	2019	Association of GSTP1 and ERCC1 polymorphisms with toxicity in locally advanced head and neck cancer platinum-based chemoradiotherapy treatment.	Platinum	100-108	glutathione S-transferase pi 1	Homo sapiens	15-20
31237279-2	2019	Herein, we report the first highly selective fluorogenic GSTP1 substrate, Ps-TG, and its membrane-permeable derivative Ps-TAc, for specific visualization of intracellular GSTP1 activity in cancer cells or epigenetically regulated GSTP1 expression.	Teniposide	74-79	glutathione S-transferase pi 1	Homo sapiens	57-62
31237279-2	2019	Herein, we report the first highly selective fluorogenic GSTP1 substrate, Ps-TG, and its membrane-permeable derivative Ps-TAc, for specific visualization of intracellular GSTP1 activity in cancer cells or epigenetically regulated GSTP1 expression.	Teniposide	74-79	glutathione S-transferase pi 1	Homo sapiens	171-176
31221747-5	2019	Instead, GST P1-1 sequesters and inactivates cisplatin with the aid of 2 solvent-accessible cysteines, resulting in protein subunits cross-linking, while maintaining its GSH-conjugation activity.	Cisplatin	45-54	glutathione S-transferase pi 1	Homo sapiens	9-17
31237279-2	2019	Herein, we report the first highly selective fluorogenic GSTP1 substrate, Ps-TG, and its membrane-permeable derivative Ps-TAc, for specific visualization of intracellular GSTP1 activity in cancer cells or epigenetically regulated GSTP1 expression.	Teniposide	74-79	glutathione S-transferase pi 1	Homo sapiens	171-176
31221747-5	2019	Instead, GST P1-1 sequesters and inactivates cisplatin with the aid of 2 solvent-accessible cysteines, resulting in protein subunits cross-linking, while maintaining its GSH-conjugation activity.	Cysteine	92-101	glutathione S-transferase pi 1	Homo sapiens	9-17
30488289-9	2019	GSTP1-methyl patients showed a higher prevalence of diabetes mellitus (p = 0.01), colonic polyps (p = 0.05), and were more resistant to SSA (p = 0.02) as compared to GSTP1 unmethylated patients (GSTP1-unmethyl).	SerSA	136-139	glutathione S-transferase pi 1	Homo sapiens	0-5
31221747-5	2019	Instead, GST P1-1 sequesters and inactivates cisplatin with the aid of 2 solvent-accessible cysteines, resulting in protein subunits cross-linking, while maintaining its GSH-conjugation activity.	Glutathione	170-173	glutathione S-transferase pi 1	Homo sapiens	9-17
31058353-9	2019	We demonstrate application of the proposed method to real data from the Epidemiological Research on Autism Spectrum Disorder (ASD) in Jamaica (ERAJ) by examining interactions between exposure to manganese and glutathione S-transferase family gene, GSTP1 in relation to ASD.	Manganese	195-204	glutathione S-transferase pi 1	Homo sapiens	248-253
31389389-0	2019	Promoter methylation and Ile105val polymorphism of GSTP1 gene in the modulation of colorectal cancer risk in ethnic Kashmiri population.	ile105val	25-34	glutathione S-transferase pi 1	Homo sapiens	51-56
30488289-10	2019	Patients GSTP1-unmethyl and AHR wild-type were the most sensitive to SSA treatment, while those with both GSTP1-methyl and AHR rs2066853 variant were all resistant to SSA (p = 0.01).	SerSA	69-72	glutathione S-transferase pi 1	Homo sapiens	9-14
30488289-11	2019	CONCLUSIONS: In acromegaly, GSTP1 gene methylation associates with resistance to SSA treatment, especially in patients carrying also the AHR rs2066853 variant, and with increased prevalence of colonic polyps and diabetes mellitus.	SerSA	81-84	glutathione S-transferase pi 1	Homo sapiens	28-33
31019568-0	2019	Overexpression of long noncoding RNA LINC01419 in esophageal squamous cell carcinoma and its relation to the sensitivity to 5-fluorouracil by mediating GSTP1 methylation.	Fluorouracil	124-138	glutathione S-transferase pi 1	Homo sapiens	152-157
31249357-0	2019	GSTM1, GSTT1 and GSTP1 Ile105Val polymorphisms in outcomes of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation.	ile105val	23-32	glutathione S-transferase pi 1	Homo sapiens	17-22
31249357-0	2019	GSTM1, GSTT1 and GSTP1 Ile105Val polymorphisms in outcomes of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation.	Cisplatin	122-131	glutathione S-transferase pi 1	Homo sapiens	17-22
31249357-2	2019	Glutathione S-transferases (GSTs) participate in CDDP excretion from cells, and genes encoding GSTs, GSTM1, GSTT1and GSTP1, are polymorphic in humans.	Cisplatin	49-53	glutathione S-transferase pi 1	Homo sapiens	117-122
31249357-10	2019	Our findings provide preliminary evidence that inherited abnormalities in CDDP metabolism, related to GSTT1 and GSTP1 Ile105Val polymorphisms, alter outcomes of HNSCC patients treated with CDDP and RT.	ile105val	118-127	glutathione S-transferase pi 1	Homo sapiens	112-117
31249357-10	2019	Our findings provide preliminary evidence that inherited abnormalities in CDDP metabolism, related to GSTT1 and GSTP1 Ile105Val polymorphisms, alter outcomes of HNSCC patients treated with CDDP and RT.	Cisplatin	74-78	glutathione S-transferase pi 1	Homo sapiens	112-117
31263672-0	2019	Transcriptional Activation of Gstp1 by MEK/ERK Signaling Confers Chemo-Resistance to Cisplatin in Lung Cancer Stem Cells.	Cisplatin	85-94	glutathione S-transferase pi 1	Homo sapiens	30-35
31263672-8	2019	Further, transcriptional activation of Gstp1 expression by MEK/ERK signaling underlies cisplatin resistance in lung CSC cells.	Cisplatin	87-96	glutathione S-transferase pi 1	Homo sapiens	39-44
30361796-11	2019	CONCLUSION: The GSTP1 c.313A&gt;G variant may increase the risk of low-frequency HL in pediatric oncology patients treated with cisplatin or carboplatin chemotherapy.	Cisplatin	128-137	glutathione S-transferase pi 1	Homo sapiens	16-21
30361796-11	2019	CONCLUSION: The GSTP1 c.313A&gt;G variant may increase the risk of low-frequency HL in pediatric oncology patients treated with cisplatin or carboplatin chemotherapy.	Carboplatin	141-152	glutathione S-transferase pi 1	Homo sapiens	16-21
31019568-2	2019	Herein, this study elucidates the role and mechanism by which LINC01419 regulates the DNA methylation of glutathione S-transferase pi 1 (GSTP1) in relation to ESCC progression and the sensitivity of ESCC cells to 5-fluorouracil (5-FU).	Fluorouracil	213-227	glutathione S-transferase pi 1	Homo sapiens	105-135
31019568-2	2019	Herein, this study elucidates the role and mechanism by which LINC01419 regulates the DNA methylation of glutathione S-transferase pi 1 (GSTP1) in relation to ESCC progression and the sensitivity of ESCC cells to 5-fluorouracil (5-FU).	Fluorouracil	213-227	glutathione S-transferase pi 1	Homo sapiens	137-142
31019568-2	2019	Herein, this study elucidates the role and mechanism by which LINC01419 regulates the DNA methylation of glutathione S-transferase pi 1 (GSTP1) in relation to ESCC progression and the sensitivity of ESCC cells to 5-fluorouracil (5-FU).	Fluorouracil	229-233	glutathione S-transferase pi 1	Homo sapiens	105-135
31019568-2	2019	Herein, this study elucidates the role and mechanism by which LINC01419 regulates the DNA methylation of glutathione S-transferase pi 1 (GSTP1) in relation to ESCC progression and the sensitivity of ESCC cells to 5-fluorouracil (5-FU).	Fluorouracil	229-233	glutathione S-transferase pi 1	Homo sapiens	137-142
31019568-7	2019	Notably, LINC01419 could bind to the promoter region of the GSTP1 gene, resulting in elevated GSTP1 methylation and reduced GSTP1 levels via the recruitment of DNA methyltransferase among ESCC cells, whereby ESCC progression was stimulated accompanied by reduced ESCC cell sensitivity to 5-FU.	Fluorouracil	288-292	glutathione S-transferase pi 1	Homo sapiens	60-65
31019568-8	2019	GSTP1 demethylation by 5-Aza-CdR was observed to reverse the effects of LINC01419 overexpression in ESCC cells and the response to 5-FU.	Fluorouracil	131-135	glutathione S-transferase pi 1	Homo sapiens	0-5
31019568-9	2019	Conclusion: Highly expressed LINC01419 in ESCC promotes GSTP1 methylation, which ultimately acts to promote the event of ESCC and diminish the sensitivity of ESCC cells to 5-FU, highlighting a novel potential strategy to improve 5-FU-based chemotherapy in ESCC.	Fluorouracil	172-176	glutathione S-transferase pi 1	Homo sapiens	56-61
31019568-9	2019	Conclusion: Highly expressed LINC01419 in ESCC promotes GSTP1 methylation, which ultimately acts to promote the event of ESCC and diminish the sensitivity of ESCC cells to 5-FU, highlighting a novel potential strategy to improve 5-FU-based chemotherapy in ESCC.	Fluorouracil	229-233	glutathione S-transferase pi 1	Homo sapiens	56-61
30870506-3	2019	GSTP1 c.313A>G genotype was recently described as a predictor of vomiting related to high-dose cisplatin.	Cisplatin	95-104	glutathione S-transferase pi 1	Homo sapiens	0-5
30121884-0	2019	Association Between GSTP1 Ile105Val Genetic Polymorphism and Dependency to Heroin and Opium.	Heroin	75-81	glutathione S-transferase pi 1	Homo sapiens	20-25
30121884-3	2019	There are several polymorphisms in the GSTP1, including Ile105Val (rs1695).	ile105val	56-65	glutathione S-transferase pi 1	Homo sapiens	39-44
30121884-4	2019	This polymorphism leads to an Ile105Val amino acid change and may alter the GSTP1 enzyme activity.	ile105val	30-39	glutathione S-transferase pi 1	Homo sapiens	76-81
30153423-7	2019	Our results revealed a novel potential mechanism of HDV-induced liver injury and hepatocarcinogenesis: s-HDAg can inhibit GSTP1 expression by directly binding to GSTP1 mRNA, which leads to accumulation of cellular ROS, resulting in high cellular apoptotic ratios and increased selective pressure for malignant transformation.	Reactive Oxygen Species	214-217	glutathione S-transferase pi 1	Homo sapiens	122-127
30153423-7	2019	Our results revealed a novel potential mechanism of HDV-induced liver injury and hepatocarcinogenesis: s-HDAg can inhibit GSTP1 expression by directly binding to GSTP1 mRNA, which leads to accumulation of cellular ROS, resulting in high cellular apoptotic ratios and increased selective pressure for malignant transformation.	Reactive Oxygen Species	214-217	glutathione S-transferase pi 1	Homo sapiens	162-167
30890751-6	2019	These various outcomes could also be attenuated by silencing of glutathione S-transferase P1 (GSTP1), a mediator of metabolic alterations and drug resistance in various cancers, and a regulator of cysteine oxidation.	Cysteine	197-205	glutathione S-transferase pi 1	Homo sapiens	64-92
30890751-6	2019	These various outcomes could also be attenuated by silencing of glutathione S-transferase P1 (GSTP1), a mediator of metabolic alterations and drug resistance in various cancers, and a regulator of cysteine oxidation.	Cysteine	197-205	glutathione S-transferase pi 1	Homo sapiens	94-99
30890751-7	2019	Collectively, our findings indicate DUOX1 deficiency in lung cancers promotes dysregulated EGFR signaling and enhanced GSTP1-mediated turnover of EGFR cysteine oxidation, which result in enhanced nuclear EGFR localization and tumorigenic properties.	Cysteine	151-159	glutathione S-transferase pi 1	Homo sapiens	119-124
30548113-0	2019	A Covalent Inhibitor for Glutathione S-Transferase Pi (GSTP1-1 ) in Human Cells.	Glutathione	25-36	glutathione S-transferase pi 1	Homo sapiens	55-62
30633885-6	2019	The cellular ROS increase was at least partially due to the suppression of glutathione-S-transferase P1 (GSTP1) by A-macB.	Reactive Oxygen Species	13-16	glutathione S-transferase pi 1	Homo sapiens	75-103
30623722-7	2019	In patients with tubular dysfunction, enhanced urinary iron and transferrin excretion were associated with distal tubular injury as indicated by increased urinary glutathione S-transferase pi 1-1 (GSTP1-1) excretion.	Iron	55-59	glutathione S-transferase pi 1	Homo sapiens	163-195
30623722-7	2019	In patients with tubular dysfunction, enhanced urinary iron and transferrin excretion were associated with distal tubular injury as indicated by increased urinary glutathione S-transferase pi 1-1 (GSTP1-1) excretion.	Iron	55-59	glutathione S-transferase pi 1	Homo sapiens	197-204
30854066-0	2019	GSTP1 as a potential predictive factor for adverse events associated with platinum-based antitumor agent-induced peripheral neuropathy.	Platinum	74-82	glutathione S-transferase pi 1	Homo sapiens	0-5
30854066-3	2019	In the present study, it was determined whether GSTP1 can predict adverse events associated with platinum-based antitumor agent-induced peripheral neuropathy among Japanese patients.	Platinum	97-105	glutathione S-transferase pi 1	Homo sapiens	48-53
30854066-11	2019	The aforementioned indicated that GSTP1 genetic polymorphism is associated with peripheral neuropathy induced by oxaliplatin treatment for colorectal cancer, and therefore serves as a predictive marker.	Oxaliplatin	113-124	glutathione S-transferase pi 1	Homo sapiens	34-39
30633885-6	2019	The cellular ROS increase was at least partially due to the suppression of glutathione-S-transferase P1 (GSTP1) by A-macB.	Reactive Oxygen Species	13-16	glutathione S-transferase pi 1	Homo sapiens	105-110
32542099-0	2020	Sulodexide up-regulates glutathione S-transferase P1 by enhancing Nrf2 expression and translocation in human umbilical vein endothelial cells injured by oxygen glucose deprivation.	glucuronyl glucosamine glycan sulfate	0-10	glutathione S-transferase pi 1	Homo sapiens	24-52
32542099-4	2020	We postulate that up-regulation of glutathione-S-transferase P1 (GSTP1) mediated by the transcription factor Nrf2 could be associated with the antioxidant effect of SDX on vascular endothelial cells.	glucuronyl glucosamine glycan sulfate	165-168	glutathione S-transferase pi 1	Homo sapiens	35-63
32542099-4	2020	We postulate that up-regulation of glutathione-S-transferase P1 (GSTP1) mediated by the transcription factor Nrf2 could be associated with the antioxidant effect of SDX on vascular endothelial cells.	glucuronyl glucosamine glycan sulfate	165-168	glutathione S-transferase pi 1	Homo sapiens	65-70
32542099-8	2020	Conclusions: SDX induces a rapid onset of the antioxidant response by up-regulating the expression of GSTP1 and Nrf2 in endothelial cells subjected to in vitro simulated ischemia.	glucuronyl glucosamine glycan sulfate	13-16	glutathione S-transferase pi 1	Homo sapiens	102-107
30499150-10	2019	Viability of GSTP1 knockdown cells treated with cisplatin was lower than that of control cells (P &lt; .01).	Cisplatin	48-57	glutathione S-transferase pi 1	Homo sapiens	13-18
30499150-11	2019	Moreover, the frequency of early and late apoptosis in GSTP1 knockdown cells was markedly increased over that of control cells by cisplatin exposure (P &lt; .01).	Cisplatin	130-139	glutathione S-transferase pi 1	Homo sapiens	55-60