PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28347724-8	2017	2h-intermittent access to sucralose did not result in significant changes in body composition, but caused a stronger expression of CART in the hypothalamus.	Deuterium	0-2	CART prepropeptide	Mus musculus	131-135
28347724-8	2017	2h-intermittent access to sucralose did not result in significant changes in body composition, but caused a stronger expression of CART in the hypothalamus.	trichlorosucrose	26-35	CART prepropeptide	Mus musculus	131-135
27338624-11	2016	Furthermore, CART increased beta cell exocytosis, altered the glucose-induced Ca(2+) signalling pattern in mouse islets from fast to slow oscillations and improved synchronisation of the oscillations between different islet regions.	Glucose	62-69	CART prepropeptide	Mus musculus	13-17
27080622-11	2016	Interestingly, the respiratory exchange ratio for CART-/- mice, which shifted from lower at RT to higher at TN with respect to WT controls, indicates a transition of relative fuel source preference from fat to carbohydrate in the absence of CART signaling.	Carbohydrates	210-222	CART prepropeptide	Mus musculus	50-54
22823101-0	2014	Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice.	Ethanol	8-15	CART prepropeptide	Mus musculus	46-91
27273815-8	2016	Collectively, our main findings indicate that high-fat diet induced-hypertension and autonomic imbalance are associated to an upregulation of CART levels in the DMH of mice.	1,2-Dimethylhydrazine	161-164	CART prepropeptide	Mus musculus	142-146
26780979-13	2016	Plasma levels for CARTp were significantly elevated in TB but not PF mice whereas levels of TSH were unaffected.	Terbium	55-57	CART prepropeptide	Mus musculus	18-23
25959573-8	2015	CART treatment of APP/PS1 mice also reduced reactive oxygen species and 4-hydroxynonenal, and mitigated oxidative DNA damage.	4-hydroxy-2-nonenal	72-88	CART prepropeptide	Mus musculus	0-4
25655433-4	2015	RESULTS: Our data showed that both CB1 null models display a marked decrease in proopiomelanocortin (POMC) and cocaine-amphetamine-regulated transcript (CART) expression in the arcuate nucleus of the hypothalamus (ARC).	Cocaine	111-118	CART prepropeptide	Mus musculus	153-157
25655433-4	2015	RESULTS: Our data showed that both CB1 null models display a marked decrease in proopiomelanocortin (POMC) and cocaine-amphetamine-regulated transcript (CART) expression in the arcuate nucleus of the hypothalamus (ARC).	Amphetamine	119-130	CART prepropeptide	Mus musculus	153-157
25010400-0	2014	Cocaine- and amphetamine-regulated transcript facilitates the neurite outgrowth in cortical neurons after oxygen and glucose deprivation through PTN-dependent pathway.	Oxygen	106-112	CART prepropeptide	Mus musculus	0-45
25010400-1	2014	Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide that plays neuroprotective roles in cerebral ischemia and reperfusion (I/R) injury in animal models or oxygen and glucose deprivation (OGD) in cultured neurons.	Oxygen	174-180	CART prepropeptide	Mus musculus	0-45
25010400-1	2014	Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide that plays neuroprotective roles in cerebral ischemia and reperfusion (I/R) injury in animal models or oxygen and glucose deprivation (OGD) in cultured neurons.	Oxygen	174-180	CART prepropeptide	Mus musculus	47-51
24748481-6	2014	These results suggest common and distinct regulation of CART by desipramine and citalopram treatments in the FST and raise the possibility that CART in the AcbSh, dBNST, and CeA may be involved in antidepressant-like effect in the FST.	Desipramine	64-75	CART prepropeptide	Mus musculus	56-60
24748481-6	2014	These results suggest common and distinct regulation of CART by desipramine and citalopram treatments in the FST and raise the possibility that CART in the AcbSh, dBNST, and CeA may be involved in antidepressant-like effect in the FST.	Citalopram	80-90	CART prepropeptide	Mus musculus	56-60
25959573-7	2015	Exogenous CART treatment in APP/PS1 mice prevented depolarization of the mitochondrial membrane and stimulated mitochondrial complex I and II activities, resulting in an increase in ATP levels.	Adenosine Triphosphate	182-185	CART prepropeptide	Mus musculus	10-14
25959573-8	2015	CART treatment of APP/PS1 mice also reduced reactive oxygen species and 4-hydroxynonenal, and mitigated oxidative DNA damage.	Reactive Oxygen Species	44-67	CART prepropeptide	Mus musculus	0-4
25820086-0	2015	Increase in cocaine- and amphetamine-regulated transcript (CART) in specific areas of the mouse brain by acute caffeine administration.	Caffeine	111-119	CART prepropeptide	Mus musculus	12-57
25820086-0	2015	Increase in cocaine- and amphetamine-regulated transcript (CART) in specific areas of the mouse brain by acute caffeine administration.	Caffeine	111-119	CART prepropeptide	Mus musculus	59-63
25820086-2	2015	Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine.	Caffeine	32-40	CART prepropeptide	Mus musculus	199-203
25820086-2	2015	Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine.	Caffeine	240-248	CART prepropeptide	Mus musculus	152-197
25820086-2	2015	Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine.	Caffeine	240-248	CART prepropeptide	Mus musculus	199-203
25820086-3	2015	Indeed, a recent study demonstrated that repeated caffeine administration increases CART in the mouse striatum.	Caffeine	50-58	CART prepropeptide	Mus musculus	84-88
25820086-5	2015	To explore this possibility, we investigated the dose- and time-dependent changes in CART immunoreactivity (CART-IR) after a single dose of caffeine in mice.	Caffeine	140-148	CART prepropeptide	Mus musculus	85-89
25820086-5	2015	To explore this possibility, we investigated the dose- and time-dependent changes in CART immunoreactivity (CART-IR) after a single dose of caffeine in mice.	Caffeine	140-148	CART prepropeptide	Mus musculus	108-112
25820086-6	2015	We found that a high dose of caffeine (100 mg/kg) significantly increased CART-IR 2 h after administration in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), central nucleus of the amygdala (CeA), paraventricular hypothalamic nucleus (PVN), arcuate hypothalamic nucleus (Arc), and locus coeruleus (LC), and returned to control levels after 8 h. But this increase was not observed in other brain areas.	Caffeine	29-37	CART prepropeptide	Mus musculus	74-78
25820086-7	2015	In addition, caffeine administration at doses of 25 and 50 mg/kg appears to produce dose-dependent increases in CART-IR in these brain areas; however, the magnitude of increase in CART-IR observed at a dose of 50 mg/kg was similar or greater than that observed at a dose of 100 mg/kg.	Caffeine	13-21	CART prepropeptide	Mus musculus	112-116
25820086-7	2015	In addition, caffeine administration at doses of 25 and 50 mg/kg appears to produce dose-dependent increases in CART-IR in these brain areas; however, the magnitude of increase in CART-IR observed at a dose of 50 mg/kg was similar or greater than that observed at a dose of 100 mg/kg.	Caffeine	13-21	CART prepropeptide	Mus musculus	180-184
25820086-8	2015	This result suggests that CART-IR in AcbSh, dBNST, CeA, PVN, Arc, and LC is selectively affected by caffeine administration.	Caffeine	100-108	CART prepropeptide	Mus musculus	26-30
25729269-0	2015	Predominant D1 Receptors Involvement in the Over-expression of CART Peptides after Repeated Cocaine Administration.	Cocaine	92-99	CART prepropeptide	Mus musculus	63-67
25729269-1	2015	The aim of this study was to investigate the involvement of dopaminergic receptors (DR) in behavioral sensitization, as measured by locomotor activity, and the over-expression of cocaine- and amphetamine-regulated transcript (CART) peptides after repeated administration of cocaine in mice.	Cocaine	179-186	CART prepropeptide	Mus musculus	226-230
25729269-2	2015	Repeated administrations of cocaine induced behavioral sensitization and CART over-expression in mice.	Cocaine	28-35	CART prepropeptide	Mus musculus	73-77
25729269-6	2015	The concomitant administration of both D1R and D2R antagonists, SCH 23390 (D1R selective) and raclopride (D2R selective), blocked cocaine induced-behavioral sensitization, CART over-expression, and cyclic adenosine 5"-monophosphate (cAMP)/protein kinase A (PKA)/phospho-cAMP response element-binding protein (pCREB) signal pathways.	SCH 23390	64-73	CART prepropeptide	Mus musculus	172-176
25729269-6	2015	The concomitant administration of both D1R and D2R antagonists, SCH 23390 (D1R selective) and raclopride (D2R selective), blocked cocaine induced-behavioral sensitization, CART over-expression, and cyclic adenosine 5"-monophosphate (cAMP)/protein kinase A (PKA)/phospho-cAMP response element-binding protein (pCREB) signal pathways.	Raclopride	94-104	CART prepropeptide	Mus musculus	172-176
25729269-10	2015	It is suggested that behavioral sensitization, CART over-expression and activated cAMP/PKA/pCREB signal pathways induced by repeated administration of cocaine could be more predominantly mediated by D1R.	Cocaine	151-158	CART prepropeptide	Mus musculus	47-51
24748481-0	2014	Effect of desipramine and citalopram treatment on forced swimming test-induced changes in cocaine- and amphetamine-regulated transcript (CART) immunoreactivity in mice.	Desipramine	10-21	CART prepropeptide	Mus musculus	90-135
24748481-0	2014	Effect of desipramine and citalopram treatment on forced swimming test-induced changes in cocaine- and amphetamine-regulated transcript (CART) immunoreactivity in mice.	Desipramine	10-21	CART prepropeptide	Mus musculus	137-141
24748481-0	2014	Effect of desipramine and citalopram treatment on forced swimming test-induced changes in cocaine- and amphetamine-regulated transcript (CART) immunoreactivity in mice.	Citalopram	26-36	CART prepropeptide	Mus musculus	90-135
24748481-0	2014	Effect of desipramine and citalopram treatment on forced swimming test-induced changes in cocaine- and amphetamine-regulated transcript (CART) immunoreactivity in mice.	Citalopram	26-36	CART prepropeptide	Mus musculus	137-141
24748481-2	2014	To explore this possibility, we assessed the treatment effects of desipramine and citalopram, which inhibit the reuptake of norepinephrine and serotonin into the presynaptic terminals, respectively, on changes in levels of CART-IR before and after the test swim in mouse brain.	Desipramine	66-77	CART prepropeptide	Mus musculus	223-227
24748481-2	2014	To explore this possibility, we assessed the treatment effects of desipramine and citalopram, which inhibit the reuptake of norepinephrine and serotonin into the presynaptic terminals, respectively, on changes in levels of CART-IR before and after the test swim in mouse brain.	Citalopram	82-92	CART prepropeptide	Mus musculus	223-227
24748481-2	2014	To explore this possibility, we assessed the treatment effects of desipramine and citalopram, which inhibit the reuptake of norepinephrine and serotonin into the presynaptic terminals, respectively, on changes in levels of CART-IR before and after the test swim in mouse brain.	Norepinephrine	124-138	CART prepropeptide	Mus musculus	223-227
24748481-2	2014	To explore this possibility, we assessed the treatment effects of desipramine and citalopram, which inhibit the reuptake of norepinephrine and serotonin into the presynaptic terminals, respectively, on changes in levels of CART-IR before and after the test swim in mouse brain.	Serotonin	143-152	CART prepropeptide	Mus musculus	223-227
24748481-4	2014	This increase in CART-IR in the AcbSh, dBNST, and PVN before the test swim remained elevated by desipramine treatment after the test swim, but this increase in these brain areas returned to near control levels after test swim by citalopram treatment.	Desipramine	96-107	CART prepropeptide	Mus musculus	17-21
24748481-4	2014	This increase in CART-IR in the AcbSh, dBNST, and PVN before the test swim remained elevated by desipramine treatment after the test swim, but this increase in these brain areas returned to near control levels after test swim by citalopram treatment.	Citalopram	229-239	CART prepropeptide	Mus musculus	17-21
24748481-5	2014	Citalopram, but not desipramine, treatment increased levels of CART-IR in the central nucleus of the amygdala (CeA) and the locus ceruleus (LC) before the test swim, and this increase was returned to control levels after the test swim in the CeA, but not in the LC.	Citalopram	0-10	CART prepropeptide	Mus musculus	63-67
22823101-0	2014	Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice.	Ethanol	8-15	CART prepropeptide	Mus musculus	93-97
22823101-3	2014	The current study utilized a CART knockout (KO) mouse model to investigate the role of CART in ethanol appetitive behaviors.	Ethanol	95-102	CART prepropeptide	Mus musculus	87-91
22823101-8	2014	CART KO mice consumed and preferred ethanol less than their WT counterparts in both sexes.	Ethanol	36-43	CART prepropeptide	Mus musculus	0-4
22823101-10	2014	There was also no difference in ethanol sensitivity in male mice; however, CART KO female mice showed a greater ethanol sensitivity than the WT females.	Ethanol	112-119	CART prepropeptide	Mus musculus	75-79
22823101-11	2014	Taken together, these data demonstrate a role for CART in ethanol appetitive behaviors and as a possible therapeutic drug target for alcoholism and abstinence enhancement.	Ethanol	58-65	CART prepropeptide	Mus musculus	50-54
24366314-0	2014	Caffeine induces behavioural sensitization and overexpression of cocaine-regulated and amphetamine-regulated transcript peptides in mice.	Caffeine	0-8	CART prepropeptide	Mus musculus	65-119
24366314-1	2014	This study examined whether repeated administration of caffeine would induce behavioural sensitization and overexpression of cocaine-regulated and amphetamine-regulated transcript (CART) peptides in mice.	Caffeine	55-63	CART prepropeptide	Mus musculus	125-179
24366314-1	2014	This study examined whether repeated administration of caffeine would induce behavioural sensitization and overexpression of cocaine-regulated and amphetamine-regulated transcript (CART) peptides in mice.	Caffeine	55-63	CART prepropeptide	Mus musculus	181-185
24366314-5	2014	Significant increases in CART mRNA levels were observed on day 3 and peaked at day 5 of caffeine administration, and then decreased gradually.	Caffeine	88-96	CART prepropeptide	Mus musculus	25-29
24366314-10	2014	Caffeine-induced overexpression of CART peptides was associated with the inhibition of A1R and A(2A)R, and the activation of cAMP/PKA/pCREB signalling.	Caffeine	0-8	CART prepropeptide	Mus musculus	35-39
24366314-10	2014	Caffeine-induced overexpression of CART peptides was associated with the inhibition of A1R and A(2A)R, and the activation of cAMP/PKA/pCREB signalling.	Cyclic AMP	125-129	CART prepropeptide	Mus musculus	35-39
24366314-11	2014	Moreover, the A(2A)R-D2R heterodimer might be involved in the overexpression of CART peptides induced by caffeine.	Caffeine	105-113	CART prepropeptide	Mus musculus	80-84
21544003-0	2011	Single-chain variable fragments antibody of CART inhibits the expression of cocaine-induced behavioral sensitization.	Cocaine	76-83	CART prepropeptide	Mus musculus	44-48
24048859-8	2013	Importantly, we also demonstrated that DMH NPY neurons coexpress cocaine amphetamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked earlier in the progression of DIO.	1,2-Dimethylhydrazine	39-42	CART prepropeptide	Mus musculus	65-105
24048859-8	2013	Importantly, we also demonstrated that DMH NPY neurons coexpress cocaine amphetamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked earlier in the progression of DIO.	1,2-Dimethylhydrazine	39-42	CART prepropeptide	Mus musculus	107-111
24048859-8	2013	Importantly, we also demonstrated that DMH NPY neurons coexpress cocaine amphetamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked earlier in the progression of DIO.	1,2-Dimethylhydrazine	151-154	CART prepropeptide	Mus musculus	123-127
24048859-10	2013	First, NPY and CART are coexpressed in the same neurons within the DMH, and second, leptin stimulates DMH NPY neurons.	1,2-Dimethylhydrazine	67-70	CART prepropeptide	Mus musculus	15-19
23585179-4	2013	We observed for the first time a difference in the gene expression pattern of cocaine and amphetamine related transcript (CART) in the (lateral hypothalamic area (LHA) resulting from the deletion of the kinin B1 receptor gene.	Amphetamine	90-101	CART prepropeptide	Mus musculus	122-126
23543038-5	2013	Neuropeptide CART (cocaine-amphetamine-regulated transcript), a hypothalamus and midbrain enriched neurotransmitter with an antioxidant property, can be found in mitochondria, which is the main source of reactive oxygen species.	Reactive Oxygen Species	204-227	CART prepropeptide	Mus musculus	13-17
23543038-5	2013	Neuropeptide CART (cocaine-amphetamine-regulated transcript), a hypothalamus and midbrain enriched neurotransmitter with an antioxidant property, can be found in mitochondria, which is the main source of reactive oxygen species.	Reactive Oxygen Species	204-227	CART prepropeptide	Mus musculus	19-59
22235287-1	2012	The multifunctional neuropeptide Cocaine and Amphetamine Regulated Transcript (CART) is secreted from hypothalamus, pituitary, adrenal gland and pancreas.	Cocaine	33-40	CART prepropeptide	Mus musculus	79-83
22235287-1	2012	The multifunctional neuropeptide Cocaine and Amphetamine Regulated Transcript (CART) is secreted from hypothalamus, pituitary, adrenal gland and pancreas.	Amphetamine	45-56	CART prepropeptide	Mus musculus	79-83
22235287-4	2012	In the present study, we demonstrate that CART protects mitochondrial DNA (mtDNA), cellular proteins and lipids against the oxidative action of hydrogen peroxide, a widely used oxidant.	Hydrogen Peroxide	144-161	CART prepropeptide	Mus musculus	42-46
22235287-5	2012	Using cis-parinaric acid as a sensitive reporting probe for peroxidation in membranes, and a lipid-soluble azo initiator of peroxyl radicals, 2,2"-azobis(2,4-dimethylvaleronitrile) we found that CART is an antioxidant.	2,4-dimethylpentanenitrile	154-179	CART prepropeptide	Mus musculus	195-199
21544003-5	2011	Single administration of CART scFv (intraperitoneal 0.04, 0.2, and 1 mg/kg) reduced the increasing locomotor activity induced by chronic cocaine intake in mice (P<0.05-0.01), but failed to affect the locomotor activity of naive mice.	Cocaine	137-144	CART prepropeptide	Mus musculus	25-29
21738744-7	2011	Furthermore, Western blot analysis and quantitative real-time reverse transcription polymerase chain reaction demonstrated that ICER overexpression abolished the METH-induced increase in CREB expression and repressed cocaine- and amphetamine-regulated transcript (CART) and prodynorphin (Pdyn) expression in mice.	Methamphetamine	162-166	CART prepropeptide	Mus musculus	264-268
21738744-8	2011	The decreased CART and Pdyn mRNA expression levels in vivo may underlie the inhibitory role of ICER in METH-induced locomotor sensitization.	Methamphetamine	103-107	CART prepropeptide	Mus musculus	14-18
19093718-0	2009	Anorexigenic effect of cholecystokinin is lost but that of CART (Cocaine and Amphetamine Regulated Transcript) peptide is preserved in monosodium glutamate obese mice.	Cocaine	65-72	CART prepropeptide	Mus musculus	59-63
19093718-0	2009	Anorexigenic effect of cholecystokinin is lost but that of CART (Cocaine and Amphetamine Regulated Transcript) peptide is preserved in monosodium glutamate obese mice.	Amphetamine	77-88	CART prepropeptide	Mus musculus	59-63
19093718-0	2009	Anorexigenic effect of cholecystokinin is lost but that of CART (Cocaine and Amphetamine Regulated Transcript) peptide is preserved in monosodium glutamate obese mice.	Sodium Glutamate	135-155	CART prepropeptide	Mus musculus	59-63
18644622-3	2008	Consequently, CART knockdown exacerbated neuronal cell death induced by oxygen and glucose deprivation (OGD).	Oxygen	72-78	CART prepropeptide	Mus musculus	14-18
18818282-2	2008	Although CART is not expressed in mouse ovaries, we have previously established CART as a novel intracellular regulator of estradiol production in bovine granulosa cells.	Estradiol	123-132	CART prepropeptide	Mus musculus	9-13
18818282-2	2008	Although CART is not expressed in mouse ovaries, we have previously established CART as a novel intracellular regulator of estradiol production in bovine granulosa cells.	Estradiol	123-132	CART prepropeptide	Mus musculus	80-84
18939974-3	2008	RESULTS: In fasted C57BL/6 mice, the anorexigenic effect of CART(61-102) in the doses of 0.1 or 0.5 microg/mouse was significantly enhanced by low doses of CCK-8 of 0.4 or 4 microg/kg, while 1 mg/kg dose of CCK-A receptor antagonist devazepide blocked the effect of CART(61-102) on food intake.	Devazepide	233-243	CART prepropeptide	Mus musculus	60-64
18939974-4	2008	After simultaneous administration of 0.1 microg/mouse CART(61-102) and of 4 microg/kg of CCK-8, the number of Fos-positive neurons in NTS, PVN, and DMH was significantly higher than after administration of each particular peptide.	Dimenhydrinate	148-151	CART prepropeptide	Mus musculus	54-58
18644622-6	2008	Furthermore, neuroprotection of CART is abolished by CART knockdown and by pretreatment with ERK antagonist PD98059 and U0126, but not with p38 or JNK antagonists SB203580 or SP600125.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	108-115	CART prepropeptide	Mus musculus	32-36
18644622-6	2008	Furthermore, neuroprotection of CART is abolished by CART knockdown and by pretreatment with ERK antagonist PD98059 and U0126, but not with p38 or JNK antagonists SB203580 or SP600125.	U 0126	120-125	CART prepropeptide	Mus musculus	32-36
16713658-3	2006	The first evidence of CART signaling properties came from a study demonstrating that CART 55-102 inhibited voltage-dependent intracellular calcium signaling.	Calcium	139-146	CART prepropeptide	Mus musculus	22-26
16959056-4	2007	Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT1B receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression.	CP 94253	10-18	CART prepropeptide	Mus musculus	180-225
16959056-4	2007	Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT1B receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression.	CP 94253	10-18	CART prepropeptide	Mus musculus	227-231
17634068-1	2007	We previously demonstrated that the neuropeptide cocaine- and amphetamine-regulated transcript (CART) is protective against focal cerebral ischemia in vivo and against neuronal cell death in culture induced by oxygen-glucose deprivation (OGD).	Cocaine	49-56	CART prepropeptide	Mus musculus	96-100
17634068-1	2007	We previously demonstrated that the neuropeptide cocaine- and amphetamine-regulated transcript (CART) is protective against focal cerebral ischemia in vivo and against neuronal cell death in culture induced by oxygen-glucose deprivation (OGD).	Amphetamine	62-73	CART prepropeptide	Mus musculus	96-100
17634068-5	2007	At concentrations between 0.2 and 4 nM, CART significantly increased SDH function, CII activity and ATP generation in purified mitochondria and intact neurons under baseline conditions.	Adenosine Triphosphate	100-103	CART prepropeptide	Mus musculus	40-44
17634068-6	2007	Furthermore, pretreatment with CART enhanced mitochondrial mechanisms of neuronal survival and prevented the decline in SDH and CII activities and ATP production after OGD.	Adenosine Triphosphate	147-150	CART prepropeptide	Mus musculus	31-35
17625001-12	2007	The adrenal medulla harboured numerous CART IR endocrine cells, most of which were adrenaline producing.	Epinephrine	83-93	CART prepropeptide	Mus musculus	39-43
17625001-18	2007	CONCLUSION: CART is a major neuropeptide in intrinsic neurons of the porcine GI-tract and pancreas, a major constituent of adrenaline producing adrenomedullary cells, and a novel peptide of the thyroid C-cells.	Epinephrine	123-133	CART prepropeptide	Mus musculus	12-16
17218444-5	2007	Moreover, milnacipran significantly increased hypothalamic proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) mRNA levels, while having no effect on hypothalamic neuropeptide Y, ghrelin, corticotropin-releasing hormone (CRH), and suppressor of cytokine signaling-3 mRNA levels.	Milnacipran	10-21	CART prepropeptide	Mus musculus	90-135
17218444-5	2007	Moreover, milnacipran significantly increased hypothalamic proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) mRNA levels, while having no effect on hypothalamic neuropeptide Y, ghrelin, corticotropin-releasing hormone (CRH), and suppressor of cytokine signaling-3 mRNA levels.	Milnacipran	10-21	CART prepropeptide	Mus musculus	137-141
17913892-4	2007	We show here that direct stimulation of serotonin (5-hydroxytryptamine, 5-HT) 4 receptors (5-HT(4)R) in the NAc reduces the physiological drive to eat and increases CART (cocaine- and amphetamine-regulated transcript) mRNA levels in fed and food-deprived mice.	Serotonin	40-49	CART prepropeptide	Mus musculus	165-169
17913892-4	2007	We show here that direct stimulation of serotonin (5-hydroxytryptamine, 5-HT) 4 receptors (5-HT(4)R) in the NAc reduces the physiological drive to eat and increases CART (cocaine- and amphetamine-regulated transcript) mRNA levels in fed and food-deprived mice.	Serotonin	40-49	CART prepropeptide	Mus musculus	171-216
17913892-4	2007	We show here that direct stimulation of serotonin (5-hydroxytryptamine, 5-HT) 4 receptors (5-HT(4)R) in the NAc reduces the physiological drive to eat and increases CART (cocaine- and amphetamine-regulated transcript) mRNA levels in fed and food-deprived mice.	Serotonin	51-70	CART prepropeptide	Mus musculus	165-169
17913892-4	2007	We show here that direct stimulation of serotonin (5-hydroxytryptamine, 5-HT) 4 receptors (5-HT(4)R) in the NAc reduces the physiological drive to eat and increases CART (cocaine- and amphetamine-regulated transcript) mRNA levels in fed and food-deprived mice.	Serotonin	51-70	CART prepropeptide	Mus musculus	171-216
17913892-7	2007	Results include that 5-HT(4)R control CART mRNA expression into the NAc via a cAMP/PKA signaling pathway.	Cyclic AMP	78-82	CART prepropeptide	Mus musculus	38-42
17913892-10	2007	Finally, stimulating 5-HT(4)R- and MDMA-induced anorexia were both reduced by injecting CART siRNA into the NAc.	N-Methyl-3,4-methylenedioxyamphetamine	35-39	CART prepropeptide	Mus musculus	88-92
16713658-3	2006	The first evidence of CART signaling properties came from a study demonstrating that CART 55-102 inhibited voltage-dependent intracellular calcium signaling.	Calcium	139-146	CART prepropeptide	Mus musculus	85-89
16621045-4	2006	In this report, we demonstrate that knockout mice lacking a functional CART gene show similar cocaine-induced locomotor sensitization and cocaine self-administration to their wild type siblings.	Cocaine	94-101	CART prepropeptide	Mus musculus	71-75
16621045-4	2006	In this report, we demonstrate that knockout mice lacking a functional CART gene show similar cocaine-induced locomotor sensitization and cocaine self-administration to their wild type siblings.	Cocaine	138-145	CART prepropeptide	Mus musculus	71-75
16131814-0	2005	Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide.	anandamide	95-105	CART prepropeptide	Mus musculus	0-43
16099925-7	2005	Amphetamine elicited conditioned place preference in both genotypes, but amphetamine"s potency was reduced in the Cart KO mice.	Amphetamine	73-84	CART prepropeptide	Mus musculus	114-118
16099925-8	2005	Intravenous cocaine self-administration was observed in both genotypes, but Cart KO mice consumed less cocaine and responded less for cocaine than WT mice.	Cocaine	103-110	CART prepropeptide	Mus musculus	76-80
16099925-8	2005	Intravenous cocaine self-administration was observed in both genotypes, but Cart KO mice consumed less cocaine and responded less for cocaine than WT mice.	Cocaine	103-110	CART prepropeptide	Mus musculus	76-80
16099925-11	2005	The attenuated effects of amphetamine and cocaine in Cart KO mice suggest a positive neuromodulatory role for CART peptides in the locomotor and motivational properties of psychostimulants and implicate CART peptides in psychostimulant addiction.	Amphetamine	26-37	CART prepropeptide	Mus musculus	53-57
16099925-11	2005	The attenuated effects of amphetamine and cocaine in Cart KO mice suggest a positive neuromodulatory role for CART peptides in the locomotor and motivational properties of psychostimulants and implicate CART peptides in psychostimulant addiction.	Amphetamine	26-37	CART prepropeptide	Mus musculus	110-114
16099925-11	2005	The attenuated effects of amphetamine and cocaine in Cart KO mice suggest a positive neuromodulatory role for CART peptides in the locomotor and motivational properties of psychostimulants and implicate CART peptides in psychostimulant addiction.	Cocaine	42-49	CART prepropeptide	Mus musculus	53-57
16099925-11	2005	The attenuated effects of amphetamine and cocaine in Cart KO mice suggest a positive neuromodulatory role for CART peptides in the locomotor and motivational properties of psychostimulants and implicate CART peptides in psychostimulant addiction.	Cocaine	42-49	CART prepropeptide	Mus musculus	110-114
15908120-5	2005	U0126, an inhibitor of the MEK kinases, blocked the CART-stimulated activation of ERKs.	U 0126	0-5	CART prepropeptide	Mus musculus	52-56
15927717-9	2005	Consistent with this, CART KO mice displayed impaired glucose-stimulated insulin secretion both in vivo after an intravenous glucose challenge and in vitro following incubation of isolated islets in the presence of glucose.	Glucose	54-61	CART prepropeptide	Mus musculus	22-26
15927717-9	2005	Consistent with this, CART KO mice displayed impaired glucose-stimulated insulin secretion both in vivo after an intravenous glucose challenge and in vitro following incubation of isolated islets in the presence of glucose.	Glucose	125-132	CART prepropeptide	Mus musculus	22-26
15927717-9	2005	Consistent with this, CART KO mice displayed impaired glucose-stimulated insulin secretion both in vivo after an intravenous glucose challenge and in vitro following incubation of isolated islets in the presence of glucose.	Glucose	125-132	CART prepropeptide	Mus musculus	22-26
15724149-6	2005	This discrepancy is explained, in part, by the fact that CART ("cocaine amphetamine regulated transcript"), a neuropeptide whose expression is controlled by leptin and nearly abolished in ob/ob mice, inhibits bone resorption by modulating Rankl expression.	cocaine amphetamine	64-83	CART prepropeptide	Mus musculus	57-61
16131814-6	2005	Acute treatment of wild-type mice with the cannabinoid agonist HU-210 resulted in elevated CART levels in the dorsomedial nucleus and the shell portion of the nucleus accumbens.	Cannabinoids	43-54	CART prepropeptide	Mus musculus	91-95
16131814-6	2005	Acute treatment of wild-type mice with the cannabinoid agonist HU-210 resulted in elevated CART levels in the dorsomedial nucleus and the shell portion of the nucleus accumbens.	HU 211	63-69	CART prepropeptide	Mus musculus	91-95
16131814-7	2005	These observations are compatible with CART being a downstream mediator of the CB1-mediated orexigenic effect of endogenous anandamide.	anandamide	124-134	CART prepropeptide	Mus musculus	39-43
15207912-1	2004	Changes in Cocaine- and Amphetamine-Regulated Transcript (CART) mRNA levels have been observed in brain as a result of various physiologic stimuli including feeding, drugs of abuse, stress and glucocorticoids, and activators of the cyclic AMP (cAMP) and protein kinase A (PKA) pathway.	Cyclic AMP	232-242	CART prepropeptide	Mus musculus	11-56
15451376-0	2004	Intrathecal CART (55-102) enhances the spinal analgesic actions of morphine in mice.	Morphine	67-75	CART prepropeptide	Mus musculus	12-16
15451376-6	2004	administration of CART (55-102) significantly enhanced the antinociceptive effect of morphine in the tail-flick test.	Morphine	85-93	CART prepropeptide	Mus musculus	18-22
15207912-1	2004	Changes in Cocaine- and Amphetamine-Regulated Transcript (CART) mRNA levels have been observed in brain as a result of various physiologic stimuli including feeding, drugs of abuse, stress and glucocorticoids, and activators of the cyclic AMP (cAMP) and protein kinase A (PKA) pathway.	Cyclic AMP	232-242	CART prepropeptide	Mus musculus	58-62
15207912-1	2004	Changes in Cocaine- and Amphetamine-Regulated Transcript (CART) mRNA levels have been observed in brain as a result of various physiologic stimuli including feeding, drugs of abuse, stress and glucocorticoids, and activators of the cyclic AMP (cAMP) and protein kinase A (PKA) pathway.	Cyclic AMP	244-248	CART prepropeptide	Mus musculus	11-56
15207912-1	2004	Changes in Cocaine- and Amphetamine-Regulated Transcript (CART) mRNA levels have been observed in brain as a result of various physiologic stimuli including feeding, drugs of abuse, stress and glucocorticoids, and activators of the cyclic AMP (cAMP) and protein kinase A (PKA) pathway.	Cyclic AMP	244-248	CART prepropeptide	Mus musculus	58-62
15207912-5	2004	cAMP regulation was detected in the construct containing 641 bp of CART promoter sequence which contains a consensus CRE site.	Cyclic AMP	0-4	CART prepropeptide	Mus musculus	67-71
15207912-9	2004	This study provides evidence that the CRE site in the CART proximal promoter is involved in cAMP/PKA/CREB regulation in cells having a neuronal phenotype.	Cyclic AMP	92-96	CART prepropeptide	Mus musculus	54-58
12600694-4	2003	CART-(55-102)-induced anxiogenic-like behavior in this task was attenuated by widely prescribed anxiolytics such as diazepam and buspirone.	Diazepam	116-124	CART prepropeptide	Mus musculus	0-4
12600694-4	2003	CART-(55-102)-induced anxiogenic-like behavior in this task was attenuated by widely prescribed anxiolytics such as diazepam and buspirone.	Buspirone	129-138	CART prepropeptide	Mus musculus	0-4
12600694-6	2003	Both diazepam and buspirone significantly reversed CART-(55-102)-induced anxiogenic-like behavior in social interaction tests.	Diazepam	5-13	CART prepropeptide	Mus musculus	51-55
12600694-6	2003	Both diazepam and buspirone significantly reversed CART-(55-102)-induced anxiogenic-like behavior in social interaction tests.	Buspirone	18-27	CART prepropeptide	Mus musculus	51-55
12421341-1	2002	In the hypothalamic arcuate nucleus, neurones that coexpress cocaine-amphetamine-regulated transcript (CART) and alpha-melanocyte-stimulating hormone [alpha-MSH; pro-opiomelanocortin (POMC) derived] peptides exert catabolic actions and are stimulated by leptin.	Cocaine	61-68	CART prepropeptide	Mus musculus	103-107
12421341-1	2002	In the hypothalamic arcuate nucleus, neurones that coexpress cocaine-amphetamine-regulated transcript (CART) and alpha-melanocyte-stimulating hormone [alpha-MSH; pro-opiomelanocortin (POMC) derived] peptides exert catabolic actions and are stimulated by leptin.	Amphetamine	69-80	CART prepropeptide	Mus musculus	103-107
12213131-6	2002	CART mRNA abundance in the arcuate nucleus of goldthioglucose-treated mice was decreased by 71% compared to levels in the control mice, but CART expression was unaffected in the dorsolateral hypothalamus.	Aurothioglucose	46-61	CART prepropeptide	Mus musculus	0-4
9654146-0	1998	Purification and characterisation of a new hypothalamic satiety peptide, cocaine and amphetamine regulated transcript (CART), produced in yeast.	Amphetamine	85-96	CART prepropeptide	Mus musculus	119-123
11564703-1	2001	Cart (cocaine- and amphetamine-regulated transcript) was first identified to be a major brain mRNA up-regulated by cocaine and amphetamine.	Cocaine	6-13	CART prepropeptide	Mus musculus	0-4
11564703-1	2001	Cart (cocaine- and amphetamine-regulated transcript) was first identified to be a major brain mRNA up-regulated by cocaine and amphetamine.	Amphetamine	19-30	CART prepropeptide	Mus musculus	0-4
11561216-1	2001	This study was designed to investigate the effects of cocaine-amphetamine-regulated transcript (CART), a recently discovered hypothalamic neuropeptide, on food intake, anxiety, oxygen consumption and gastric emptying in mice.	Oxygen	177-183	CART prepropeptide	Mus musculus	96-100
11561216-5	2001	Furthermore, the i. c. v. injection of CART significantly reduced oxygen consumption and gastric emptying rate.	Oxygen	66-72	CART prepropeptide	Mus musculus	39-43
10612702-6	1999	Lastly, in a study of mice treated with the neurotoxin, monosodium glutamate, which targets the arcuate nucleus, a near-total ablation of CART peptide immunoreactive cell bodies in this nucleus was accompanied by decreased terminal staining for CART peptide in the paraventricular hypothalamic nucleus, the arcuate nucleus itself and in the dorsomedial hypothalamic nucleus.	Glutamic Acid	67-76	CART prepropeptide	Mus musculus	138-142
10612702-6	1999	Lastly, in a study of mice treated with the neurotoxin, monosodium glutamate, which targets the arcuate nucleus, a near-total ablation of CART peptide immunoreactive cell bodies in this nucleus was accompanied by decreased terminal staining for CART peptide in the paraventricular hypothalamic nucleus, the arcuate nucleus itself and in the dorsomedial hypothalamic nucleus.	Glutamic Acid	67-76	CART prepropeptide	Mus musculus	245-249
9654146-1	1998	Cocaine and amphetamine regulated transcript (CART) is a newly discovered hypothalamic peptide with a potent appetite suppressing activity following intracerebroventricular administration.	Cocaine	0-7	CART prepropeptide	Mus musculus	46-50
9654146-1	1998	Cocaine and amphetamine regulated transcript (CART) is a newly discovered hypothalamic peptide with a potent appetite suppressing activity following intracerebroventricular administration.	Amphetamine	12-23	CART prepropeptide	Mus musculus	46-50
9654146-4	1998	In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1.	Glutamic Acid	46-49	CART prepropeptide	Mus musculus	19-23
9654146-4	1998	In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1.	Glutamic Acid	46-49	CART prepropeptide	Mus musculus	62-66
9654146-4	1998	In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1.	Glutamic Acid	46-49	CART prepropeptide	Mus musculus	62-66
9654146-4	1998	In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1.	Glutamic Acid	50-53	CART prepropeptide	Mus musculus	19-23
9654146-4	1998	In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1.	Glutamic Acid	50-53	CART prepropeptide	Mus musculus	62-66
9654146-4	1998	In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1.	Glutamic Acid	50-53	CART prepropeptide	Mus musculus	62-66
9654146-4	1998	In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1.	Aspartic Acid	58-61	CART prepropeptide	Mus musculus	19-23
9654146-4	1998	In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1.	Aspartic Acid	58-61	CART prepropeptide	Mus musculus	62-66
9654146-4	1998	In order to obtain CART(55-102) the precursor Glu-Glu-Ile-Asp-CART(55-102) has been produced and CART(55-102) was generated by digestion of the precursor with dipeptidylaminopeptidase-1.	Aspartic Acid	58-61	CART prepropeptide	Mus musculus	62-66
9654146-6	1998	The CART peptides contain six cysteine residues and using the yeast expressed CART(62-102) the disulphide bond configuration was found to be I-III, II-V and IV-VI.	Cysteine	30-38	CART prepropeptide	Mus musculus	4-8
9654146-6	1998	The CART peptides contain six cysteine residues and using the yeast expressed CART(62-102) the disulphide bond configuration was found to be I-III, II-V and IV-VI.	disulphide	95-105	CART prepropeptide	Mus musculus	4-8
9654146-6	1998	The CART peptides contain six cysteine residues and using the yeast expressed CART(62-102) the disulphide bond configuration was found to be I-III, II-V and IV-VI.	disulphide	95-105	CART prepropeptide	Mus musculus	78-82
33604684-3	2021	Previous studies have reported that cocaine amphetamine regulated transcript (CART) treatment improves memory and synaptic structure in APP/PS1 mice.	cocaine amphetamine	36-55	CART prepropeptide	Mus musculus	78-82
34380043-6	2021	Excitingly, both adoptive CAR-T and anti-PD1 immune checkpoint blockade mouse models demonstrate that NAD+ supplementation enhanced the tumor-killing efficacy of T cells.	NAD	102-106	CART prepropeptide	Mus musculus	26-31
35447308-7	2022	Of note, it was the first time that the existence of neurons expressing the calcium binding protein calbindin, the neuropeptide Y (NPY) and the cocain and amphetamine regulated transcript (CART) peptide, was described in the mouse.	Amphetamine	155-166	CART prepropeptide	Mus musculus	189-193
34489705-14	2021	Compared with untreated group and 5-FU group, CHB-II-F also enhanced the expression of OX1R, GHSR, NPY, and AgRP protein and gene and decreased the expression of Ob-R, POMC, and CART protein and gene in hypothalamus of mice, and the gene expression was consistent with the protein expression.	Fluorouracil	34-38	CART prepropeptide	Mus musculus	178-182
31150057-7	2019	Moreover, the CART promoter has depleted 5-methylcytosine (5mC) and enriched 5-hydroxymethylcytosine (5hmC) levels.	5-Methylcytosine	41-57	CART prepropeptide	Mus musculus	14-18
32855216-0	2020	Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose.	Glucose	71-78	CART prepropeptide	Mus musculus	21-25
31742872-7	2020	However, irisin injection increased CART, POMC, NPY, and BDNF mRNA levels, without affecting the mRNA expression of AgRP, orexin, PMCH, and UCP2.	irisin	9-15	CART prepropeptide	Mus musculus	36-40
31980629-4	2020	Cocaine activated the transcription factor, Nr4a1, and its target gene, Cartpt, a key molecule involved in dopamine metabolism.	Cocaine	0-7	CART prepropeptide	Mus musculus	72-78
31980629-4	2020	Cocaine activated the transcription factor, Nr4a1, and its target gene, Cartpt, a key molecule involved in dopamine metabolism.	Dopamine	107-115	CART prepropeptide	Mus musculus	72-78
31980629-5	2020	Sustained activation of Cartpt at late abstinence was coupled with depletion of the repressive histone modification, H3K27me3, and enrichment of activating marks, H3K27ac and H3K4me3.	H-2K(K) antigen	175-182	CART prepropeptide	Mus musculus	24-30
31150057-7	2019	Moreover, the CART promoter has depleted 5-methylcytosine (5mC) and enriched 5-hydroxymethylcytosine (5hmC) levels.	5-Methylcytosine	59-62	CART prepropeptide	Mus musculus	14-18
31150057-7	2019	Moreover, the CART promoter has depleted 5-methylcytosine (5mC) and enriched 5-hydroxymethylcytosine (5hmC) levels.	5-hydroxymethylcytosine	77-100	CART prepropeptide	Mus musculus	14-18
31150057-7	2019	Moreover, the CART promoter has depleted 5-methylcytosine (5mC) and enriched 5-hydroxymethylcytosine (5hmC) levels.	5-hydroxymethylcytosine	102-106	CART prepropeptide	Mus musculus	14-18
29193459-0	2019	Neuropeptide CART prevents memory loss attributed to withdrawal of nicotine following chronic treatment in mice.	Nicotine	67-75	CART prepropeptide	Mus musculus	13-17
31058074-8	2019	In addition, poly I:C decreased myeloid-derived suppressor cells (MDSC) number in peripheral blood and spleen, and attenuated the immunosuppressive activity of MDSC on proliferation and cytolytic function of CAR-T.	Poly I-C	13-21	CART prepropeptide	Mus musculus	208-213
29193459-13	2019	CART circuit dynamics in the hippocampus seems to modulate short-term memory associated with nicotine withdrawal.	Nicotine	93-101	CART prepropeptide	Mus musculus	0-4
28314964-11	2018	In the arcuate, CART was increased in HFD-fed UN mice and in CD-fed CPD mice, while HFD intake suppressed CART increase in defeated animals.	Cadmium	61-63	CART prepropeptide	Mus musculus	16-20
29627317-5	2018	CART expression was increased by fatty acids and GIP, but unaffected by glucose in GLUTag and STC-1 cells.	Fatty Acids	33-44	CART prepropeptide	Mus musculus	0-4
29627317-7	2018	Furthermore, acute intravenous administration of CART increased GIP and GLP-1 secretion during an oral glucose-tolerance test in mice.	Glucose	103-110	CART prepropeptide	Mus musculus	49-53
30066844-0	2018	Cocaine- and amphetamine-regulated transcript (CART) is associated with dopamine and is protective against ischemic stroke.	Cocaine	0-7	CART prepropeptide	Mus musculus	47-51
30066844-0	2018	Cocaine- and amphetamine-regulated transcript (CART) is associated with dopamine and is protective against ischemic stroke.	Amphetamine	13-24	CART prepropeptide	Mus musculus	47-51
30066844-0	2018	Cocaine- and amphetamine-regulated transcript (CART) is associated with dopamine and is protective against ischemic stroke.	Dopamine	72-80	CART prepropeptide	Mus musculus	47-51
30066844-8	2018	Treatment with exogenous CART promoted the survival of ex vivo neurons following oxygen-glucose deprivation (OGD), while exogenous DA induced CART mRNA expression in a dose-dependent manner, which suggested an association between CART and DA.	oxygen-glucose	81-95	CART prepropeptide	Mus musculus	25-29
28802898-0	2017	Neurochemical evidence that cocaine- and amphetamine-regulated transcript (CART) 55-102 peptide modulates the dopaminergic reward system by decreasing the dopamine release in the mouse nucleus accumbens.	Dopamine	110-118	CART prepropeptide	Mus musculus	28-73
28802898-0	2017	Neurochemical evidence that cocaine- and amphetamine-regulated transcript (CART) 55-102 peptide modulates the dopaminergic reward system by decreasing the dopamine release in the mouse nucleus accumbens.	Dopamine	110-118	CART prepropeptide	Mus musculus	75-79
28802898-2	2017	In the nucleus accumbens, known for its significant role in motivation, pleasure, reward and reinforcement learning, CART peptide inhibits cocaine and amphetamine-induced dopamine-mediated increases in locomotor activity and behavior, suggesting a CART peptide interaction with the dopaminergic system.	Cocaine	139-146	CART prepropeptide	Mus musculus	117-121
28802898-2	2017	In the nucleus accumbens, known for its significant role in motivation, pleasure, reward and reinforcement learning, CART peptide inhibits cocaine and amphetamine-induced dopamine-mediated increases in locomotor activity and behavior, suggesting a CART peptide interaction with the dopaminergic system.	Amphetamine	151-162	CART prepropeptide	Mus musculus	117-121
28802898-2	2017	In the nucleus accumbens, known for its significant role in motivation, pleasure, reward and reinforcement learning, CART peptide inhibits cocaine and amphetamine-induced dopamine-mediated increases in locomotor activity and behavior, suggesting a CART peptide interaction with the dopaminergic system.	Amphetamine	151-162	CART prepropeptide	Mus musculus	248-252
28802898-2	2017	In the nucleus accumbens, known for its significant role in motivation, pleasure, reward and reinforcement learning, CART peptide inhibits cocaine and amphetamine-induced dopamine-mediated increases in locomotor activity and behavior, suggesting a CART peptide interaction with the dopaminergic system.	Dopamine	171-179	CART prepropeptide	Mus musculus	117-121
28802898-4	2017	We further extended our study to assess the effect of CART (55-102) peptide on basal cocaine-induced release of dopamine and its metabolites DOPAL, DOPAC, HVA, DOPET and 3-MT as well as on NE and Daq.	Cocaine	85-92	CART prepropeptide	Mus musculus	54-58
28802898-4	2017	We further extended our study to assess the effect of CART (55-102) peptide on basal cocaine-induced release of dopamine and its metabolites DOPAL, DOPAC, HVA, DOPET and 3-MT as well as on NE and Daq.	Dopamine	112-120	CART prepropeptide	Mus musculus	54-58
28802898-4	2017	We further extended our study to assess the effect of CART (55-102) peptide on basal cocaine-induced release of dopamine and its metabolites DOPAL, DOPAC, HVA, DOPET and 3-MT as well as on NE and Daq.	3,4-dihydroxyphenylacetaldehyde	141-146	CART prepropeptide	Mus musculus	54-58
28802898-6	2017	CART (55-102) peptide, 0.1muM, added alone, exerted: (i) a significant decrease in the basal and EFS-evoked levels of extracellular dopamine (ii) a significant increase in the EFS-evoked and returning basal levels of the dopamine metabolites DOPAC and HVA, major products of dopamine degradation and (iii) a significant decrease in the returning basal levels of DOPET.	Dopamine	132-140	CART prepropeptide	Mus musculus	0-4
28802898-6	2017	CART (55-102) peptide, 0.1muM, added alone, exerted: (i) a significant decrease in the basal and EFS-evoked levels of extracellular dopamine (ii) a significant increase in the EFS-evoked and returning basal levels of the dopamine metabolites DOPAC and HVA, major products of dopamine degradation and (iii) a significant decrease in the returning basal levels of DOPET.	Dopamine	221-229	CART prepropeptide	Mus musculus	0-4
28802898-6	2017	CART (55-102) peptide, 0.1muM, added alone, exerted: (i) a significant decrease in the basal and EFS-evoked levels of extracellular dopamine (ii) a significant increase in the EFS-evoked and returning basal levels of the dopamine metabolites DOPAC and HVA, major products of dopamine degradation and (iii) a significant decrease in the returning basal levels of DOPET.	3,4-Dihydroxyphenylacetic Acid	242-247	CART prepropeptide	Mus musculus	0-4
28802898-6	2017	CART (55-102) peptide, 0.1muM, added alone, exerted: (i) a significant decrease in the basal and EFS-evoked levels of extracellular dopamine (ii) a significant increase in the EFS-evoked and returning basal levels of the dopamine metabolites DOPAC and HVA, major products of dopamine degradation and (iii) a significant decrease in the returning basal levels of DOPET.	Homovanillic Acid	252-255	CART prepropeptide	Mus musculus	0-4
28802898-6	2017	CART (55-102) peptide, 0.1muM, added alone, exerted: (i) a significant decrease in the basal and EFS-evoked levels of extracellular dopamine (ii) a significant increase in the EFS-evoked and returning basal levels of the dopamine metabolites DOPAC and HVA, major products of dopamine degradation and (iii) a significant decrease in the returning basal levels of DOPET.	Dopamine	221-229	CART prepropeptide	Mus musculus	0-4
28802898-6	2017	CART (55-102) peptide, 0.1muM, added alone, exerted: (i) a significant decrease in the basal and EFS-evoked levels of extracellular dopamine (ii) a significant increase in the EFS-evoked and returning basal levels of the dopamine metabolites DOPAC and HVA, major products of dopamine degradation and (iii) a significant decrease in the returning basal levels of DOPET.	3,4-dihydroxyphenylethanol	362-367	CART prepropeptide	Mus musculus	0-4
28802898-8	2017	In the presence of CART (55-102) peptide, 0.1muM, the effect of cocaine, 30muM, on the basal dopamine release was inhibited and the effect on the basal DOPAC release substantially increased.	Cocaine	64-71	CART prepropeptide	Mus musculus	19-23
28802898-8	2017	In the presence of CART (55-102) peptide, 0.1muM, the effect of cocaine, 30muM, on the basal dopamine release was inhibited and the effect on the basal DOPAC release substantially increased.	Dopamine	93-101	CART prepropeptide	Mus musculus	19-23
28802898-8	2017	In the presence of CART (55-102) peptide, 0.1muM, the effect of cocaine, 30muM, on the basal dopamine release was inhibited and the effect on the basal DOPAC release substantially increased.	3,4-Dihydroxyphenylacetic Acid	152-157	CART prepropeptide	Mus musculus	19-23
28802898-9	2017	To our knowledge, our findings are the first to show direct neurochemical evidence that CART (55-102) peptide plays a neuromodulatory role on the dopaminergic reward system by decreasing dopamine in the mouse nucleus accumbens and by attenuating cocaine-induced effects on dopamine release.	Dopamine	146-154	CART prepropeptide	Mus musculus	88-92
28802898-9	2017	To our knowledge, our findings are the first to show direct neurochemical evidence that CART (55-102) peptide plays a neuromodulatory role on the dopaminergic reward system by decreasing dopamine in the mouse nucleus accumbens and by attenuating cocaine-induced effects on dopamine release.	Cocaine	246-253	CART prepropeptide	Mus musculus	88-92
28802898-9	2017	To our knowledge, our findings are the first to show direct neurochemical evidence that CART (55-102) peptide plays a neuromodulatory role on the dopaminergic reward system by decreasing dopamine in the mouse nucleus accumbens and by attenuating cocaine-induced effects on dopamine release.	Dopamine	187-195	CART prepropeptide	Mus musculus	88-92