PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33336891-5	2021	Here, we found that PBM attenuated Abeta-induced synaptic dysfunction and neuronal death through MKP7-dependent suppression of JNK3, a brain-specific JNK isoform related to neurodegeneration.	pbm	20-23	dual specificity phosphatase 16	Mus musculus	97-101
34088892-0	2021	NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic beta cells for surviving.	Reactive Oxygen Species	69-72	dual specificity phosphatase 16	Mus musculus	15-19
34088892-6	2021	We further found that knocking down the expression of MKP7 increased the p-JNK level in pancreatic beta cells upon treatment with TG or H2O2.	Hydrogen Peroxide	136-140	dual specificity phosphatase 16	Mus musculus	54-58
34088892-8	2021	In sum, NR4A1 attenuates JNK phosphorylation incurred by ER-stress or ROS partially via enhancing MKP7 expression, potentially decreases pancreatic beta cell apoptosis induced by ROS or ER-stress.	Reactive Oxygen Species	70-73	dual specificity phosphatase 16	Mus musculus	98-102
33336891-9	2021	Furthermore, activation of ERK/MKP7 signaling by PBM increased the level of AMPA receptor subunit GluR 1 phosphorylation and attenuated AMPA receptor endocytosis in an AD pathological model.	pbm	49-52	dual specificity phosphatase 16	Mus musculus	31-35
31614510-7	2019	According to the molecular docking prediction, flumequine targeted dual-specificity MAPK phosphatase 16 (DUSP16), which is a major negative regulator of p38 MAPK and JNK.	flumequine	47-57	dual specificity phosphatase 16	Mus musculus	67-103
31982140-3	2020	Dual-specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, has been reported to negatively modulate the mitogen-activated protein kinases (MAPKs) signaling, and it has never been investigated in NAFLD progression.	Nitrogen	50-51	dual specificity phosphatase 16	Mus musculus	0-31
31982140-3	2020	Dual-specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, has been reported to negatively modulate the mitogen-activated protein kinases (MAPKs) signaling, and it has never been investigated in NAFLD progression.	Nitrogen	50-51	dual specificity phosphatase 16	Mus musculus	33-39
31614510-7	2019	According to the molecular docking prediction, flumequine targeted dual-specificity MAPK phosphatase 16 (DUSP16), which is a major negative regulator of p38 MAPK and JNK.	flumequine	47-57	dual specificity phosphatase 16	Mus musculus	105-111
27771463-0	2016	Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK.	Rosiglitazone	37-50	dual specificity phosphatase 16	Mus musculus	16-21
27771463-5	2016	The rosiglitazone-mediated increase in SIRT1 stability is accompanied by upregulation of mitogen-activated protein kinase phosphatase (MKP)-7, a JNK-specific phosphatase.	Rosiglitazone	4-17	dual specificity phosphatase 16	Mus musculus	89-141
27771463-7	2016	Furthermore, gain of MKP-7 function mimicked the effect of rosiglitazone on LPS-induced destabilization and ubiquitination of SIRT1.	Rosiglitazone	59-72	dual specificity phosphatase 16	Mus musculus	21-26
23639976-7	2013	Finally, in HR-1 hairless mice exposed to UVB, administration of GW501516 significantly reduced wrinkle formation and skin thickness, downregulated MMP-1 and JNK phosphorylation, and restored the levels of MKP-7, types I and III collagen.	GW 501516	65-73	dual specificity phosphatase 16	Mus musculus	206-211
12511574-0	2003	Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages.	Cyclic AMP	38-42	dual specificity phosphatase 16	Mus musculus	115-120
12511574-8	2003	Consistent with this, a histone deacetylase inhibitor, trichostatin A, increased endogenous mkp-M gene transcription.	trichostatin A	55-69	dual specificity phosphatase 16	Mus musculus	92-97