PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23391659-0	2013	Steroid derivatives as inhibitors of steroid sulfatase.	Steroids	0-7	steroid sulfatase	Homo sapiens	37-54
23391659-2	2013	The sulfated steroids themselves are biologically inactive and only become active in vivo when they are converted into their desulfated (unconjugated) form by the enzyme steroid sulfatase (STS).	Steroids	13-21	steroid sulfatase	Homo sapiens	170-187
23637932-4	2013	In a steroid-reduced condition, Cdc25C protein was greatly decreased in AS C-33 cells but not AI C-81 or PC-3 cells.	Steroids	5-12	steroid sulfatase	Homo sapiens	72-76
23589292-5	2013	The ROS-dependent activation, mediated by Nox4, of widely expressed redox-regulated transcription factors, such as c-Jun, is fundamental to this process.	Reactive Oxygen Species	4-7	steroid sulfatase	Homo sapiens	112-116
23466819-1	2013	Steroid sulfatase (STS) is an enzyme that hydrolyzes steroid sulfates such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate.	steroid sulfates	53-69	steroid sulfatase	Homo sapiens	0-17
23466819-1	2013	Steroid sulfatase (STS) is an enzyme that hydrolyzes steroid sulfates such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate.	Dehydroepiandrosterone Sulfate	78-108	steroid sulfatase	Homo sapiens	0-17
23466819-1	2013	Steroid sulfatase (STS) is an enzyme that hydrolyzes steroid sulfates such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate.	estrone sulfate	122-137	steroid sulfatase	Homo sapiens	0-17
23797179-0	2013	A phase I dose escalation study to determine the optimal biological dose of irosustat, an oral steroid sulfatase inhibitor, in postmenopausal women with estrogen receptor-positive breast cancer.	irosustat	76-85	steroid sulfatase	Homo sapiens	95-112
23531699-1	2013	BACKGROUND: Steroid sulphatase (STS) is one of the steroid-metabolising enzymes involved in desulphating inactive steroid sulphates and oestrogen sulphotransferase (EST) sulphates active oestrogen.	Steroids	51-58	steroid sulfatase	Homo sapiens	12-30
23531699-1	2013	BACKGROUND: Steroid sulphatase (STS) is one of the steroid-metabolising enzymes involved in desulphating inactive steroid sulphates and oestrogen sulphotransferase (EST) sulphates active oestrogen.	steroid sulphates	114-131	steroid sulfatase	Homo sapiens	12-30
23531699-1	2013	BACKGROUND: Steroid sulphatase (STS) is one of the steroid-metabolising enzymes involved in desulphating inactive steroid sulphates and oestrogen sulphotransferase (EST) sulphates active oestrogen.	Sulfates	122-131	steroid sulfatase	Homo sapiens	12-30
22455789-0	2012	Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors.	estrone-3-O-sulfamate	41-62	steroid sulfatase	Homo sapiens	73-90
23238642-7	2013	Arsenate reductase activity was found to be conferred by arsC gene, which in many strains was coupled with arsenite efflux gene arsB as well.	arsenite	107-115	steroid sulfatase	Homo sapiens	57-61
22542502-0	2012	Synthesis of 2-[11C]methoxy-3,17beta-O,O-bis(sulfamoyl)estradiol as a new potential PET agent for imaging of steroid sulfatase (STS) in cancers.	2-[11c]methoxy-3,17beta-o,o-bis(sulfamoyl)estradiol	13-64	steroid sulfatase	Homo sapiens	109-126
22542502-1	2012	Steroid sulfatase (STS) catalyzes the hydrolysis of steroid sulfates to estrones, the main source of estrogens in tumors.	steroid sulfates	52-68	steroid sulfatase	Homo sapiens	0-17
22542502-1	2012	Steroid sulfatase (STS) catalyzes the hydrolysis of steroid sulfates to estrones, the main source of estrogens in tumors.	Estrone	72-80	steroid sulfatase	Homo sapiens	0-17
24009850-1	2012	Steroid sulfatase (STS) is responsiblefor the conversion of estrone sulfate to estrone that can stimulate growth in endocrine-dependent tumors such as prostate cancer.	estrone sulfate	60-75	steroid sulfatase	Homo sapiens	0-17
24009850-1	2012	Steroid sulfatase (STS) is responsiblefor the conversion of estrone sulfate to estrone that can stimulate growth in endocrine-dependent tumors such as prostate cancer.	Estrone	60-67	steroid sulfatase	Homo sapiens	0-17
22455789-1	2012	Estrone sulfamate (EMATE) is a potent irreversible inhibitor of steroid sulfatase (STS).	estrone-3-O-sulfamate	0-17	steroid sulfatase	Homo sapiens	64-81
22358110-1	2012	Based on an ab initio evolutionary algorithm, a novel carbon polymorph with an orthorhombic Cmcm symmetry is predicted, named as C carbon, which has the lowest enthalpy among the previously proposed cold-compressed graphite phases.	Carbon	54-60	steroid sulfatase	Homo sapiens	126-130
22358110-1	2012	Based on an ab initio evolutionary algorithm, a novel carbon polymorph with an orthorhombic Cmcm symmetry is predicted, named as C carbon, which has the lowest enthalpy among the previously proposed cold-compressed graphite phases.	Carbon	131-137	steroid sulfatase	Homo sapiens	126-130
22358110-1	2012	Based on an ab initio evolutionary algorithm, a novel carbon polymorph with an orthorhombic Cmcm symmetry is predicted, named as C carbon, which has the lowest enthalpy among the previously proposed cold-compressed graphite phases.	Graphite	215-223	steroid sulfatase	Homo sapiens	126-130
22295880-9	2012	In contrast, the abundance of arsenate reducers (carrying the arsC gene) was increased by OM amendment; however, significant enhancement of activity of arsenate reducers was observed only in CT. Our results demonstrate that OM addition significantly increased As methylation and volatilization from the investigated paddy soil.	arsenic acid	30-38	steroid sulfatase	Homo sapiens	62-66
22264754-0	2012	17beta-Arylsulfonamides of 17beta-aminoestra-1,3,5(10)-trien-3-ol as highly potent inhibitors of steroid sulfatase.	17beta-arylsulfonamides	0-23	steroid sulfatase	Homo sapiens	97-114
21859802-3	2012	One such enzyme, steroid sulfatase (STS), hydrolyses estrone sulfate, and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone respectively.	estrone sulfate	53-68	steroid sulfatase	Homo sapiens	17-34
21859802-3	2012	One such enzyme, steroid sulfatase (STS), hydrolyses estrone sulfate, and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone respectively.	Dehydroepiandrosterone Sulfate	74-104	steroid sulfatase	Homo sapiens	17-34
21859802-3	2012	One such enzyme, steroid sulfatase (STS), hydrolyses estrone sulfate, and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone respectively.	Estrone	53-60	steroid sulfatase	Homo sapiens	17-34
21859802-3	2012	One such enzyme, steroid sulfatase (STS), hydrolyses estrone sulfate, and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone respectively.	Dehydroepiandrosterone	74-96	steroid sulfatase	Homo sapiens	17-34
21782294-0	2011	Chemical synthesis and evaluation of 17alpha-alkylated derivatives of estradiol as inhibitors of steroid sulfatase.	17alpha	37-44	steroid sulfatase	Homo sapiens	97-114
22264754-0	2012	17beta-Arylsulfonamides of 17beta-aminoestra-1,3,5(10)-trien-3-ol as highly potent inhibitors of steroid sulfatase.	UNII-566D62CJB8	27-65	steroid sulfatase	Homo sapiens	97-114
22264754-1	2012	Steroid sulfatase (STS) catalyzes the desulfation of biologically inactive sulfated steroids to yield biologically active desulfated steroids and is currently being examined as a target for therapeutic intervention for the treatment of breast and other steroid-dependent cancers.	Steroids	84-92	steroid sulfatase	Homo sapiens	0-17
22264754-1	2012	Steroid sulfatase (STS) catalyzes the desulfation of biologically inactive sulfated steroids to yield biologically active desulfated steroids and is currently being examined as a target for therapeutic intervention for the treatment of breast and other steroid-dependent cancers.	Steroids	133-141	steroid sulfatase	Homo sapiens	0-17
22264754-1	2012	Steroid sulfatase (STS) catalyzes the desulfation of biologically inactive sulfated steroids to yield biologically active desulfated steroids and is currently being examined as a target for therapeutic intervention for the treatment of breast and other steroid-dependent cancers.	Steroids	84-91	steroid sulfatase	Homo sapiens	0-17
21523537-4	2012	Pyrimidine-2,4-diamine was selected as A-ring, and naphthalene and benzene were chosen as C/D-ring.	naphthalene	51-62	steroid sulfatase	Homo sapiens	87-91
21523537-4	2012	Pyrimidine-2,4-diamine was selected as A-ring, and naphthalene and benzene were chosen as C/D-ring.	Benzene	67-74	steroid sulfatase	Homo sapiens	87-91
21458474-1	2011	The steroid sulfatase (STS) plays a major role in the regulation of steroid hormone concentrations in several human tissues and target organs and therefore, represents an interesting target to regulate estrogen and androgen levels implicated in different diseases.	Steroids	68-83	steroid sulfatase	Homo sapiens	4-21
21593448-4	2011	Cell death was induced by H(2)O(2) (1,000 muM) or staurosporine (StSp, 5 muM), and it was shown that cold shock and RBM3 transfection were associated with attenuation of morphological changes and an increase in cell viability compared with normal temperature or empty vector, respectively.	Staurosporine	50-63	steroid sulfatase	Homo sapiens	65-69
21608133-0	2011	Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates.	Letrozole	67-76	steroid sulfatase	Homo sapiens	29-46
21608133-0	2011	Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates.	vorozole	81-89	steroid sulfatase	Homo sapiens	29-46
22975513-1	2012	Steroid sulfatase (STS) plays an important role in steroid metabolism in which estrogens and dehydroepiandrosterone (DHEA) are produced from their sulfates.	Steroids	51-58	steroid sulfatase	Homo sapiens	0-17
22975513-1	2012	Steroid sulfatase (STS) plays an important role in steroid metabolism in which estrogens and dehydroepiandrosterone (DHEA) are produced from their sulfates.	Dehydroepiandrosterone	93-115	steroid sulfatase	Homo sapiens	0-17
22975513-1	2012	Steroid sulfatase (STS) plays an important role in steroid metabolism in which estrogens and dehydroepiandrosterone (DHEA) are produced from their sulfates.	Dehydroepiandrosterone	117-121	steroid sulfatase	Homo sapiens	0-17
25961347-0	2011	Effect of tibolone and its principal metabolites (3alpha- and 3beta-hydroxy, 3alpha-sulfate, and 4-ene derivatives) on estrone sulfatase activity in normal and cancerous human breast tissue.	tibolone	10-18	steroid sulfatase	Homo sapiens	119-136
25961347-3	2011	We compared the dose response of tibolone and its metabolites on estrone sulfatase activity [conversion of estrone sulfate (E1S) to estrone (E1)] in normal and cancerous human breast tissues.	tibolone	33-41	steroid sulfatase	Homo sapiens	65-82
25961347-3	2011	We compared the dose response of tibolone and its metabolites on estrone sulfatase activity [conversion of estrone sulfate (E1S) to estrone (E1)] in normal and cancerous human breast tissues.	estrone sulfate	107-122	steroid sulfatase	Homo sapiens	65-82
21904110-1	2011	Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and has a pivotal role in regulating the formation of biologically active estrogens.	aryl	61-65	steroid sulfatase	Homo sapiens	0-17
21904110-1	2011	Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and has a pivotal role in regulating the formation of biologically active estrogens.	steroid sulfates	76-92	steroid sulfatase	Homo sapiens	0-17
21990014-0	2011	Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495).	irosustat	92-101	steroid sulfatase	Homo sapiens	64-81
21990014-0	2011	Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495).	irosustat	103-108	steroid sulfatase	Homo sapiens	64-81
21990014-0	2011	Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495).	irosustat	110-117	steroid sulfatase	Homo sapiens	64-81
21925885-0	2011	Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives.	4-substituted estrone	37-58	steroid sulfatase	Homo sapiens	14-31
21925885-0	2011	Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives.	Estradiol	63-72	steroid sulfatase	Homo sapiens	14-31
21925885-1	2011	Steroid sulfatase (STS) catalyzes the desulfation of biologically inactive sulfated steroids to yield biologically active desulfated steroids and is currently being examined as a target for therapeutic intervention for the treatment of breast cancer.	Steroids	84-92	steroid sulfatase	Homo sapiens	0-17
21925885-1	2011	Steroid sulfatase (STS) catalyzes the desulfation of biologically inactive sulfated steroids to yield biologically active desulfated steroids and is currently being examined as a target for therapeutic intervention for the treatment of breast cancer.	Steroids	133-141	steroid sulfatase	Homo sapiens	0-17
21782294-0	2011	Chemical synthesis and evaluation of 17alpha-alkylated derivatives of estradiol as inhibitors of steroid sulfatase.	Estradiol	70-79	steroid sulfatase	Homo sapiens	97-114
21782294-1	2011	Steroid sulfatase (STS) controls the levels of 3-hydroxysteroids available from circulating steroid sulfates in several normal and malignant tissues.	3-hydroxysteroids	47-64	steroid sulfatase	Homo sapiens	0-17
21782294-1	2011	Steroid sulfatase (STS) controls the levels of 3-hydroxysteroids available from circulating steroid sulfates in several normal and malignant tissues.	steroid sulfates	92-108	steroid sulfatase	Homo sapiens	0-17
20888390-1	2011	Aromatase, estrone sulfatase, and 17beta-hydroxysteroid dehydrogenase type 1 are involved in the key steps of 17beta-estradiol biosynthesis.	Estradiol	110-126	steroid sulfatase	Homo sapiens	11-28
21073915-2	2011	Estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase (STS), while estrone is inversely inactivated into estrone sulfate by estrogen sulfotransferase (EST).	Estrone	0-7	steroid sulfatase	Homo sapiens	73-90
21238537-1	2011	Hydrolysis of biologically inactive steroid sulfates to unconjugated steroids by steroid sulfatase (STS) is strongly implicated in rendering estrogenic stimulation to hormone-dependent cancers such as those of the breast.	steroid sulfates	36-52	steroid sulfatase	Homo sapiens	81-98
21238537-1	2011	Hydrolysis of biologically inactive steroid sulfates to unconjugated steroids by steroid sulfatase (STS) is strongly implicated in rendering estrogenic stimulation to hormone-dependent cancers such as those of the breast.	Steroids	69-77	steroid sulfatase	Homo sapiens	81-98
20297840-2	2010	Steroidal sulfamate esters, inhibitors of the cancer drug target steroid sulfatase (STS), are sequestered in vivo by CA II in red blood cells, which may be the origin of their excellent drug properties.	sulfamate esters	10-26	steroid sulfatase	Homo sapiens	65-82
21508387-0	2011	Effect of tamoxifen or anastrozole on steroid sulfatase activity and serum androgen concentrations in postmenopausal women with breast cancer.	Anastrozole	23-34	steroid sulfatase	Homo sapiens	38-55
21508387-1	2011	BACKGROUND: In postmenopausal women estrogens can be formed by the aromatase pathway, which gives rise to estrone, and the steroid sulfatase (STS) route which can result in the formation of estrogens and androstenediol, a steroid with potent estrogenic properties.	Androstenediol	204-218	steroid sulfatase	Homo sapiens	123-140
21356310-4	2011	One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively.	steroid sulfates	80-96	steroid sulfatase	Homo sapiens	41-58
21356310-4	2011	One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively.	estrone sulfate	102-117	steroid sulfatase	Homo sapiens	41-58
21356310-4	2011	One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively.	Estrone	119-122	steroid sulfatase	Homo sapiens	41-58
21356310-4	2011	One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively.	Dehydroepiandrosterone Sulfate	128-158	steroid sulfatase	Homo sapiens	41-58
21356310-4	2011	One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively.	Dehydroepiandrosterone Sulfate	160-165	steroid sulfatase	Homo sapiens	41-58
21356310-4	2011	One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively.	Estrone	102-109	steroid sulfatase	Homo sapiens	41-58
21356310-4	2011	One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively.	Estrone	119-121	steroid sulfatase	Homo sapiens	41-58
21356310-4	2011	One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively.	Dehydroepiandrosterone	128-150	steroid sulfatase	Homo sapiens	41-58
21356310-4	2011	One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively.	Dehydroepiandrosterone	160-164	steroid sulfatase	Homo sapiens	41-58
21123062-0	2011	Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors.	2,4-diaminopyrimidine	30-51	steroid sulfatase	Homo sapiens	52-56
25961215-4	2010	Estrone sulfatase activity is also inhibited by norelgestromin, a norgestimate metabolite.	norelgestromin	48-62	steroid sulfatase	Homo sapiens	0-17
25961215-4	2010	Estrone sulfatase activity is also inhibited by norelgestromin, a norgestimate metabolite.	norgestimate	66-78	steroid sulfatase	Homo sapiens	0-17
20632362-0	2010	Bicyclic derivatives of the potent dual aromatase-steroid sulfatase inhibitor 2-bromo-4-{[(4-cyanophenyl)(4h-1,2,4-triazol-4-yl)amino]methyl}phenylsulfamate: synthesis, SAR, crystal structure, and in vitro and in vivo activities.	2-bromo-4-{[(4-cyanophenyl)(4h-1,2,4-triazol-4-yl)amino]methyl}phenylsulfamate	78-156	steroid sulfatase	Homo sapiens	50-67
20482580-1	2010	Nitrogen (N) effects on ecosystem carbon (C) budgets are critical to understand as C sequestration is considered as a mechanism to offset anthropogenic CO(2) emissions.	Nitrogen	0-8	steroid sulfatase	Homo sapiens	80-84
20482580-1	2010	Nitrogen (N) effects on ecosystem carbon (C) budgets are critical to understand as C sequestration is considered as a mechanism to offset anthropogenic CO(2) emissions.	Carbon	34-40	steroid sulfatase	Homo sapiens	80-84
20482580-1	2010	Nitrogen (N) effects on ecosystem carbon (C) budgets are critical to understand as C sequestration is considered as a mechanism to offset anthropogenic CO(2) emissions.	co(2)	152-157	steroid sulfatase	Homo sapiens	80-84
20441141-9	2010	Flow-through experiments with RO concentrate yielded surface area normalized first-order rate constants for NDMA (40.6 +/- 3.7 L/m(2) h) and DOC (as C) (38.3 +/- 2.2 L/m(2) h) removal that were mass transfer limited at a 2 mA/cm(2) current density.	ro	30-32	steroid sulfatase	Homo sapiens	146-150
19795339-0	2010	Testicular steroid hormone secretion in the boar and expression of testicular and epididymal steroid sulphatase and estrogen sulphotransferase activity.	Steroids	11-26	steroid sulfatase	Homo sapiens	101-111
20007855-10	2010	LC-induced reduction in CVC was smaller (P < 0.05) at L-NAME + Asc sites (-23 +/- 8%) than at L-NAME sites (-43 +/- 7%).	NG-Nitroarginine Methyl Ester	57-63	steroid sulfatase	Homo sapiens	66-69
19833350-1	2010	A homologue of carboxylate gemini surfactants with an azobenzene spacer and different lengths of the alkyl tails, referred to as C(m)(azo)C(m), has been synthesized.	carboxylate	15-26	steroid sulfatase	Homo sapiens	126-130
20814163-1	2010	Steroid sulfatase (STS) is a microsomal enzyme responsible for the formation of 3beta-hydroxysteroid from the corresponding sulfate conjugates.	3beta-Hydroxysteroid	80-100	steroid sulfatase	Homo sapiens	0-17
20814163-1	2010	Steroid sulfatase (STS) is a microsomal enzyme responsible for the formation of 3beta-hydroxysteroid from the corresponding sulfate conjugates.	Sulfates	124-131	steroid sulfatase	Homo sapiens	0-17
20001046-10	2009	The value of the arsenic quadrupole coupling constant (eqQ=-202 MHz) suggests that the As-C bond has a mixture of covalent and ionic characters, consistent with theoretical predictions that both pi backbonding and electron transfer play a role in creating a linear, as opposed to a cyclic, structure for certain heteroatom dicarbides.	Arsenic	17-24	steroid sulfatase	Homo sapiens	87-91
20134249-14	2010	While many isolates were genetically diverse, others were clonal in nature Additionally, the arsenic-resistant isolates were examined for the presence of arsenic resistance (ars) genes by using PCR, and 30% of the isolates were found to carry an arsenate reductase encoded by the arsC gene.	Arsenic	93-100	steroid sulfatase	Homo sapiens	280-284
20001046-10	2009	The value of the arsenic quadrupole coupling constant (eqQ=-202 MHz) suggests that the As-C bond has a mixture of covalent and ionic characters, consistent with theoretical predictions that both pi backbonding and electron transfer play a role in creating a linear, as opposed to a cyclic, structure for certain heteroatom dicarbides.	dicarbides	323-333	steroid sulfatase	Homo sapiens	87-91
20049111-6	2009	Further, arylsulfatase C, which reactivates endogenous sulfated estrogens, develops early in life and so may deconjugate BPA sulfate in newborns.	bpa sulfate	121-132	steroid sulfatase	Homo sapiens	9-24
18440760-3	2008	In estrogen-sensitive tissues, e.g. the female breast, estrone sulfate (E1S), present at high concentrations in the circulation, is converted into the biologically active estrone (E1) by steroid sulfatase (STS) and again reverted into E1S by estrogen sulfotransferase (SULT1E1) providing a local estrogen storage.	estrone sulfate	55-70	steroid sulfatase	Homo sapiens	187-204
19429462-1	2009	Steroid sulfatase (STS) is a membrane-bound microsomal enzyme that hydrolyzes various alkyl and aryl steroid sulfates, leading to the in situ formation of biologically active hormones.	alkyl and aryl steroid sulfates	86-117	steroid sulfatase	Homo sapiens	0-17
19250194-1	2009	Steroid sulfatase (STS) hydrolyses biologically inactive estrogen sulfates to active estrogens, while estrogen sulfotransferase (EST) sulfonates estrogens to estrogen sulfates.	estrogen sulfates	57-74	steroid sulfatase	Homo sapiens	0-17
19250194-1	2009	Steroid sulfatase (STS) hydrolyses biologically inactive estrogen sulfates to active estrogens, while estrogen sulfotransferase (EST) sulfonates estrogens to estrogen sulfates.	estrogen sulfates	158-175	steroid sulfatase	Homo sapiens	0-17
19250195-1	2009	Steroid sulfatase (STS) regulates the hydrolysis of steroid sulfates to their unconjugated forms.	steroid sulfates	52-68	steroid sulfatase	Homo sapiens	0-17
18855575-1	2008	The steroid sulfatase (STS) enzyme plays a pivotal role in the formation of biologically active steroid hormones.	Steroids	96-112	steroid sulfatase	Homo sapiens	4-21
18288656-1	2008	Pseudomonas aeruginosa arylsulfatase catalyses the cleavage of aryl sulfates and is an excellent model for human estrone sulfatase, which is implicated in hormone-dependent breast cancer.	phenylsulfate	63-76	steroid sulfatase	Homo sapiens	113-130
18590272-0	2008	Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.	Letrozole	74-83	steroid sulfatase	Homo sapiens	36-53
18590272-1	2008	To explore aromatase inhibition and to broaden the structural diversity of dual aromatase-sulfatase inhibitors (DASIs), we introduced the steroid sulfatase (STS) inhibitory pharmacophore to letrozole.	Letrozole	190-199	steroid sulfatase	Homo sapiens	138-155
18288656-3	2008	We studied the inactivation of Pseudomonas aeruginosa arylsulfatase A by a range of aryl sulfamates, including the clinical agent 667COUMATE (STX64) used to inactivate estrone sulfatase.	irosustat	130-140	steroid sulfatase	Homo sapiens	168-185
18249534-1	2008	Neuroactive steroids (dehydroepiandrosterone, pregnenolone) and their sulfates act as modulators of glutamate and gamma-aminobutyrate type A receptors in the brain The physiological ratio of these neuromodulators is maintained by two enzymes present in the brain, namely, steroid sulfatase (STS) and steroid sulfuryl transferase (SULT).	Steroids	12-20	steroid sulfatase	Homo sapiens	272-289
18249534-1	2008	Neuroactive steroids (dehydroepiandrosterone, pregnenolone) and their sulfates act as modulators of glutamate and gamma-aminobutyrate type A receptors in the brain The physiological ratio of these neuromodulators is maintained by two enzymes present in the brain, namely, steroid sulfatase (STS) and steroid sulfuryl transferase (SULT).	Dehydroepiandrosterone	22-44	steroid sulfatase	Homo sapiens	272-289
18249534-1	2008	Neuroactive steroids (dehydroepiandrosterone, pregnenolone) and their sulfates act as modulators of glutamate and gamma-aminobutyrate type A receptors in the brain The physiological ratio of these neuromodulators is maintained by two enzymes present in the brain, namely, steroid sulfatase (STS) and steroid sulfuryl transferase (SULT).	Pregnenolone	46-58	steroid sulfatase	Homo sapiens	272-289
18261865-5	2008	Steroid sulfatase (STS) activity was evaluated by incubating homogenized breast tissue with [3H]-estrone sulfate.	Tritium	93-95	steroid sulfatase	Homo sapiens	0-17
18261865-5	2008	Steroid sulfatase (STS) activity was evaluated by incubating homogenized breast tissue with [3H]-estrone sulfate.	estrone sulfate	97-112	steroid sulfatase	Homo sapiens	0-17
18180093-1	2008	Steroid sulphatase (STS) catalyses the formation of active steroids from inactive steroid sulphates.	Steroids	59-67	steroid sulfatase	Homo sapiens	0-18
18180093-1	2008	Steroid sulphatase (STS) catalyses the formation of active steroids from inactive steroid sulphates.	steroid sulphates	82-99	steroid sulfatase	Homo sapiens	0-18
17945483-1	2008	Steroid sulfatase (STS) catalyses the hydrolysis of the sulfate esters of 3-hydroxy steroids, which are inactive transport or precursor forms of the active 3-hydroxy steroids.	sulfate esters	56-70	steroid sulfatase	Homo sapiens	0-17
18056119-0	2008	Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy.	4-methylcoumarin 7-O-sulfamate	75-82	steroid sulfatase	Homo sapiens	14-32
18056119-2	2008	In addition to the formation of estrogen via the aromatase pathway, steroid sulphatase (STS), which is responsible for the hydrolysis of estrogen sulphates, may be an important source of estrogens in endometriosis.	estrogen sulphates	137-155	steroid sulfatase	Homo sapiens	68-86
18249534-1	2008	Neuroactive steroids (dehydroepiandrosterone, pregnenolone) and their sulfates act as modulators of glutamate and gamma-aminobutyrate type A receptors in the brain The physiological ratio of these neuromodulators is maintained by two enzymes present in the brain, namely, steroid sulfatase (STS) and steroid sulfuryl transferase (SULT).	Glutamic Acid	100-109	steroid sulfatase	Homo sapiens	272-289
17945483-1	2008	Steroid sulfatase (STS) catalyses the hydrolysis of the sulfate esters of 3-hydroxy steroids, which are inactive transport or precursor forms of the active 3-hydroxy steroids.	3-hydroxy steroids	74-92	steroid sulfatase	Homo sapiens	0-17
17945483-1	2008	Steroid sulfatase (STS) catalyses the hydrolysis of the sulfate esters of 3-hydroxy steroids, which are inactive transport or precursor forms of the active 3-hydroxy steroids.	3-hydroxy steroids	156-174	steroid sulfatase	Homo sapiens	0-17
17696419-1	2007	Estradiol-3,17-O,O-bis-sulfamates inhibit steroid sulfatase (STS), carbonic anhydrase (CA), and, when substituted at C-2, cancer cell proliferation and angiogenesis.	estradiol-3,17-o,o-bis-sulfamates	0-33	steroid sulfatase	Homo sapiens	42-59
17662596-0	2007	Interactions of the human cytosolic sulfotransferases and steroid sulfatase in the metabolism of tibolone and raloxifene.	tibolone	97-105	steroid sulfatase	Homo sapiens	58-75
17662596-0	2007	Interactions of the human cytosolic sulfotransferases and steroid sulfatase in the metabolism of tibolone and raloxifene.	Raloxifene Hydrochloride	110-120	steroid sulfatase	Homo sapiens	58-75
17268815-0	2007	A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models.	KW 2581	56-63	steroid sulfatase	Homo sapiens	28-45
17268815-1	2007	We screened a series of 17beta-(N-alkylcarbamoyl)-estra-1,3,5(10)trine-3-O-sulfamate derivatives, and describe here a potent and selective steroid sulfatase (STS) inhibitor with antitumor effects in breast cancer models in vitro and in vivo.	17beta-(n-alkylcarbamoyl)-estra-1,3,5(10)trine-3-o-sulfamate	24-84	steroid sulfatase	Homo sapiens	139-156
17268816-3	2007	Steroid sulfatase (STS) plays a crucial role in formation of compounds with estrogenic properties, converting inactive sulfate-conjugated steroids to active non-conjugated forms.	Sulfates	119-126	steroid sulfatase	Homo sapiens	0-17
17268816-3	2007	Steroid sulfatase (STS) plays a crucial role in formation of compounds with estrogenic properties, converting inactive sulfate-conjugated steroids to active non-conjugated forms.	Steroids	138-146	steroid sulfatase	Homo sapiens	0-17
17870531-0	2007	Synthesis of novel anilinoquinolines as c-fms inhibitors.	anilinoquinolines	19-36	steroid sulfatase	Homo sapiens	37-41
17870531-1	2007	A novel series of potent substituted anilinoquinolines were discovered as c-fms inhibitors.	anilinoquinolines	37-54	steroid sulfatase	Homo sapiens	71-75
17580843-0	2007	Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase.	Thiosemicarbazones	0-18	steroid sulfatase	Homo sapiens	73-90
17061037-1	2007	In the present study, we found that two hormone receptor-positive human breast cancer cell lines, ZR-75-1 and BT-474, naturally expressed steroid sulfatase (STS) protein and had catalytic activity to produce estrone from estrone sulfate (E1S) with a comparable level to those in human breast cancer tissues.	Estrone	208-215	steroid sulfatase	Homo sapiens	138-155
17580843-0	2007	Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase.	formyl benzoic acids	22-42	steroid sulfatase	Homo sapiens	73-90
17580843-1	2007	Thiosemicarbazones of the microbial metabolite madurahydroxylactone, a polysubstituted benzo[a]naphthacenequinone, have been previously reported by us as potent nonsteroidal inhibitors of the enzyme estrone sulfatase (cyclohexylthiosemicarbazone 1, IC50 0.46 microM).	Thiosemicarbazones	0-18	steroid sulfatase	Homo sapiens	199-216
17580843-1	2007	Thiosemicarbazones of the microbial metabolite madurahydroxylactone, a polysubstituted benzo[a]naphthacenequinone, have been previously reported by us as potent nonsteroidal inhibitors of the enzyme estrone sulfatase (cyclohexylthiosemicarbazone 1, IC50 0.46 microM).	madurahydroxylactone	47-67	steroid sulfatase	Homo sapiens	199-216
17580843-1	2007	Thiosemicarbazones of the microbial metabolite madurahydroxylactone, a polysubstituted benzo[a]naphthacenequinone, have been previously reported by us as potent nonsteroidal inhibitors of the enzyme estrone sulfatase (cyclohexylthiosemicarbazone 1, IC50 0.46 microM).	benzo[a]naphthacenequinone	87-113	steroid sulfatase	Homo sapiens	199-216
17580843-1	2007	Thiosemicarbazones of the microbial metabolite madurahydroxylactone, a polysubstituted benzo[a]naphthacenequinone, have been previously reported by us as potent nonsteroidal inhibitors of the enzyme estrone sulfatase (cyclohexylthiosemicarbazone 1, IC50 0.46 microM).	cyclohexylthiosemicarbazone	218-245	steroid sulfatase	Homo sapiens	199-216
17214375-1	2006	BACKGROUND: Steroid sulfatase (STS) is the enzyme responsible for hydrolysing biologically inactive estrogen sulfates to active estrogens.	estrogen sulfates	100-117	steroid sulfatase	Homo sapiens	12-29
17426092-2	2007	Dehydroepiandrosterone (DHEA) sulfonation is controlled by the enzymes DHEA sulfotransferase (SULT2A1) and steroid sulfatase (STS).	Dehydroepiandrosterone	0-22	steroid sulfatase	Homo sapiens	107-124
17426092-2	2007	Dehydroepiandrosterone (DHEA) sulfonation is controlled by the enzymes DHEA sulfotransferase (SULT2A1) and steroid sulfatase (STS).	Dehydroepiandrosterone	24-28	steroid sulfatase	Homo sapiens	107-124
17467267-3	2007	Tibolone and some of its metabolites act in a tissue-selective manner to inhibit steroid sulphatase (STS) and 17beta-hydroxysteroid dehydrogenase Type 1 (17beta-HSD1) activities but also stimulate steroid sulphotransferase and 17beta-HSD2 activities.	tibolone	0-8	steroid sulfatase	Homo sapiens	46-99
16978906-4	2007	Addition of arginine-glycine-aspartic acid-serine promoted Activator protein-1 binding to its cognate sequence within the Transforming growth factor-beta1 promoter as well as c-jun and c-fos protein abundance.	aspartic acid-serine	29-49	steroid sulfatase	Homo sapiens	172-176
16710859-4	2006	Some steroid sulfatase (STS) and protein tyrosine phosphatase inhibitors belonging to the sulfamide class of derivatives have also been reported.	fusarubin	90-99	steroid sulfatase	Homo sapiens	5-22
17061037-1	2007	In the present study, we found that two hormone receptor-positive human breast cancer cell lines, ZR-75-1 and BT-474, naturally expressed steroid sulfatase (STS) protein and had catalytic activity to produce estrone from estrone sulfate (E1S) with a comparable level to those in human breast cancer tissues.	estrone sulfate	221-236	steroid sulfatase	Homo sapiens	138-155
17221238-4	2007	This means that the As-C bond to the longer carbon chain was cleaved during the hydride-generation process.	Carbon	44-50	steroid sulfatase	Homo sapiens	20-24
17221238-5	2007	Theoretical calculations at the RHF/6-31G(d,p) ab initio level confirm that this As-C bond is much weaker than the As-CH(3) bonds.	rhf	32-35	steroid sulfatase	Homo sapiens	81-85
17596930-1	2007	Steroid sulfatase (STS) increases the pool of precursors of biologically active steroids, thereby playing an important role in breast cancer development.	Steroids	80-88	steroid sulfatase	Homo sapiens	0-17
17481887-0	2007	Estradiol inhibits the estrone sulfatase activity in normal and cancerous human breast tissues.	Estradiol	0-9	steroid sulfatase	Homo sapiens	23-40
21901078-3	2007	Imatinib mesylate inhibits the activation of PDGF receptor as well as c-Abl, Bcr-Abl and c-Kit tyrosine kinases.	Imatinib Mesylate	0-17	steroid sulfatase	Homo sapiens	67-71
16978906-4	2007	Addition of arginine-glycine-aspartic acid-serine promoted Activator protein-1 binding to its cognate sequence within the Transforming growth factor-beta1 promoter as well as c-jun and c-fos protein abundance.	arginine-glycine	12-28	steroid sulfatase	Homo sapiens	172-176
17049229-3	2007	Steroid sulfatase (STS) catalyses the hydrolysis of these steroids into their unconjugated counterparts.	Steroids	58-66	steroid sulfatase	Homo sapiens	0-17
16973364-0	2006	Boronic acids as inhibitors of steroid sulfatase.	Boronic Acids	0-13	steroid sulfatase	Homo sapiens	31-48
16973364-1	2006	Steroid sulfatase (STS) catalyzes the hydrolysis of steroidal sulfates such as estrone sulfate (ES1) to the corresponding steroids and inorganic sulfate.	Sulfates	62-70	steroid sulfatase	Homo sapiens	0-17
16973364-1	2006	Steroid sulfatase (STS) catalyzes the hydrolysis of steroidal sulfates such as estrone sulfate (ES1) to the corresponding steroids and inorganic sulfate.	estrone sulfate	79-94	steroid sulfatase	Homo sapiens	0-17
16973364-1	2006	Steroid sulfatase (STS) catalyzes the hydrolysis of steroidal sulfates such as estrone sulfate (ES1) to the corresponding steroids and inorganic sulfate.	Steroids	122-130	steroid sulfatase	Homo sapiens	0-17
16973364-1	2006	Steroid sulfatase (STS) catalyzes the hydrolysis of steroidal sulfates such as estrone sulfate (ES1) to the corresponding steroids and inorganic sulfate.	Sulfates	135-152	steroid sulfatase	Homo sapiens	0-17
16931338-4	2006	BPA is a substrate for estrogen sulfotransferase, and bisphenol A sulfate (BPAS) and disulfate are substrates for estrone sulfatase.	Bisphenol A monosulfate	54-73	steroid sulfatase	Homo sapiens	114-131
16931338-4	2006	BPA is a substrate for estrogen sulfotransferase, and bisphenol A sulfate (BPAS) and disulfate are substrates for estrone sulfatase.	BPAS	75-79	steroid sulfatase	Homo sapiens	114-131
16931338-4	2006	BPA is a substrate for estrogen sulfotransferase, and bisphenol A sulfate (BPAS) and disulfate are substrates for estrone sulfatase.	Disulfate ion	85-94	steroid sulfatase	Homo sapiens	114-131
16931338-8	2006	These findings suggest a mechanism for the selective uptake of BPA into cells expressing estrone sulfatase.	bisphenol A	63-66	steroid sulfatase	Homo sapiens	89-106
16533785-1	2006	PURPOSE: Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer.	steroid sulfates	93-109	steroid sulfatase	Homo sapiens	23-40
16837617-0	2006	Tissue-specific transcriptional initiation and activity of steroid sulfatase complementing dehydroepiandrosterone sulfate uptake and intracrine steroid activations in human adipose tissue.	Dehydroepiandrosterone Sulfate	91-121	steroid sulfatase	Homo sapiens	59-76
16837617-4	2006	While sulfotransferase expression was not found, the occurrence of steroid sulfatase (STS), converting DHEA-S to DHEA, was established at the mRNA, protein and catalytic activity levels.	Dehydroepiandrosterone	103-107	steroid sulfatase	Homo sapiens	67-84
16476457-1	2006	Our rationale is based on the finding that estrone 3-sulfamate (EMATE, 2d), a typical estrone sulfatase (ES) inhibitor, can be hydrolyzed and the pharmacological effect of the free estrogen contributes to the bioactivity of the sulfamate.	estrone 3-sulfamate	43-62	steroid sulfatase	Homo sapiens	86-103
16476457-1	2006	Our rationale is based on the finding that estrone 3-sulfamate (EMATE, 2d), a typical estrone sulfatase (ES) inhibitor, can be hydrolyzed and the pharmacological effect of the free estrogen contributes to the bioactivity of the sulfamate.	sulfamic acid	53-62	steroid sulfatase	Homo sapiens	86-103
17150821-6	2006	Thus, "bisulfite genomic sequencing" involves treatment of a given DNA sample with bisulfite followed by PCR amplification and sequencing, through which C residues in the original DNA are found as T and mC as C.	hydrogen sulfite	7-16	steroid sulfatase	Homo sapiens	206-210
20141508-3	2006	Some steroid sulfatase (STS) and protein tyrosine phosphatase inhibitors belonging to the sulfamide class of derivatives have also been reported.	fusarubin	90-99	steroid sulfatase	Homo sapiens	5-22
16178776-1	2005	Steroid sulfatase (STS) is the only well characterized enzyme in human cells that is capable to desulfate estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) as a first step in the conversion of these precursors to active hormones.	estrone sulfate	106-123	steroid sulfatase	Homo sapiens	0-17
16132094-0	2005	Synthesis of a non-hydrolyzable estrone sulfate analogue bearing the difluoromethanesulfonamide group and its evaluation as a steroid sulfatase inhibitor.	estrone sulfate	32-47	steroid sulfatase	Homo sapiens	126-143
16132094-0	2005	Synthesis of a non-hydrolyzable estrone sulfate analogue bearing the difluoromethanesulfonamide group and its evaluation as a steroid sulfatase inhibitor.	DIFLUOROMETHANESULFONAMIDE	69-95	steroid sulfatase	Homo sapiens	126-143
16132094-1	2005	Steroid sulfatase (STS) catalyzes the hydrolyis of steroidal sulfates such as estrone sulfate (ES1) and is considered to be an attractive target in the treatment of steroid dependent cancers.	Sulfates	61-69	steroid sulfatase	Homo sapiens	0-17
16132094-1	2005	Steroid sulfatase (STS) catalyzes the hydrolyis of steroidal sulfates such as estrone sulfate (ES1) and is considered to be an attractive target in the treatment of steroid dependent cancers.	estrone sulfate	78-93	steroid sulfatase	Homo sapiens	0-17
16132094-1	2005	Steroid sulfatase (STS) catalyzes the hydrolyis of steroidal sulfates such as estrone sulfate (ES1) and is considered to be an attractive target in the treatment of steroid dependent cancers.	cyclo(cysteinyl-tyrosyl-norleucyl-glycyl-tryptophyl-cysteinyl)-aspartyl-phenylalaninamide	95-98	steroid sulfatase	Homo sapiens	0-17
16132094-1	2005	Steroid sulfatase (STS) catalyzes the hydrolyis of steroidal sulfates such as estrone sulfate (ES1) and is considered to be an attractive target in the treatment of steroid dependent cancers.	Steroids	51-58	steroid sulfatase	Homo sapiens	0-17
16178776-1	2005	Steroid sulfatase (STS) is the only well characterized enzyme in human cells that is capable to desulfate estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) as a first step in the conversion of these precursors to active hormones.	Estrone	125-128	steroid sulfatase	Homo sapiens	0-17
16178776-1	2005	Steroid sulfatase (STS) is the only well characterized enzyme in human cells that is capable to desulfate estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) as a first step in the conversion of these precursors to active hormones.	Dehydroepiandrosterone Sulfate	134-164	steroid sulfatase	Homo sapiens	0-17
16178776-1	2005	Steroid sulfatase (STS) is the only well characterized enzyme in human cells that is capable to desulfate estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) as a first step in the conversion of these precursors to active hormones.	Dehydroepiandrosterone Sulfate	166-171	steroid sulfatase	Homo sapiens	0-17
16022506-8	2005	Formation of the Sp lesion in the Cr(VI)/Asc oxidation reaction with DNA was confirmed by LC-ESI-MS detection.	spiroiminodihydantoin	17-19	steroid sulfatase	Homo sapiens	41-44
16022506-10	2005	Concentrations of Cr(VI) (3.1-50 microM) with a corresponding 1:10 ratio of Asc oxidized between 0.3% and 1.5% of all guanines within the duplex DNA strand to Sp.	chromium hexavalent ion	18-24	steroid sulfatase	Homo sapiens	76-79
16022506-10	2005	Concentrations of Cr(VI) (3.1-50 microM) with a corresponding 1:10 ratio of Asc oxidized between 0.3% and 1.5% of all guanines within the duplex DNA strand to Sp.	Guanine	118-126	steroid sulfatase	Homo sapiens	76-79
16022506-10	2005	Concentrations of Cr(VI) (3.1-50 microM) with a corresponding 1:10 ratio of Asc oxidized between 0.3% and 1.5% of all guanines within the duplex DNA strand to Sp.	spiroiminodihydantoin	159-161	steroid sulfatase	Homo sapiens	76-79
16399357-1	2005	Human steroid sulfatase (STS) is an enzyme that hydrolyzes several sulfated steroids, such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate, and results in the production of active substances.	Steroids	76-84	steroid sulfatase	Homo sapiens	6-23
15823201-1	2005	BACKGROUND: The purpose of this study was to localize the expression of steroid sulfatase (STS) in cumulus cells and to determine the relationship between STS mRNA expression and the serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol and progesterone.	Estradiol	261-270	steroid sulfatase	Homo sapiens	72-89
15561802-1	2005	Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and therefore has a pivotal role in regulating the formation of biologically active steroids.	aryl and alkyl steroid sulfates	61-92	steroid sulfatase	Homo sapiens	0-17
15561802-1	2005	Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and therefore has a pivotal role in regulating the formation of biologically active steroids.	Steroids	177-185	steroid sulfatase	Homo sapiens	0-17
15686949-0	2005	N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase.	n-acyl arylsulfonamides	0-23	steroid sulfatase	Homo sapiens	65-82
15860269-5	2005	Estrone sulfate (E1S) is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS).	estrone sulfate	0-15	steroid sulfatase	Homo sapiens	134-151
15862969-1	2005	2-Methoxyoestrogen sulphamates are a new class of compounds, which inhibit breast cancer cell proliferation and are also potent inhibitors of steroid sulphatase (STS) activity.	2-methoxyoestrogen sulphamates	0-30	steroid sulfatase	Homo sapiens	142-160
15862970-0	2005	The nature of inhibition of steroid sulphatase activity by tibolone and its metabolites.	tibolone	59-67	steroid sulfatase	Homo sapiens	28-46
15862971-1	2005	Sulfamoylated derivatives of the endogenous estrogen metabolite 2-methoxyestradiol (2-MeOE2 (7)), such as 2-methoxy-3-O-sulfamoyl estrone (2-MeOEMATE (1)), display greatly enhanced activity against the proliferation of human cancer cells and inhibit steroid sulphatase (STS), another current oncology target.	2-Methoxyestradiol	64-82	steroid sulfatase	Homo sapiens	250-268
15862971-1	2005	Sulfamoylated derivatives of the endogenous estrogen metabolite 2-methoxyestradiol (2-MeOE2 (7)), such as 2-methoxy-3-O-sulfamoyl estrone (2-MeOEMATE (1)), display greatly enhanced activity against the proliferation of human cancer cells and inhibit steroid sulphatase (STS), another current oncology target.	2-Methoxyestradiol	84-91	steroid sulfatase	Homo sapiens	250-268
15862971-1	2005	Sulfamoylated derivatives of the endogenous estrogen metabolite 2-methoxyestradiol (2-MeOE2 (7)), such as 2-methoxy-3-O-sulfamoyl estrone (2-MeOEMATE (1)), display greatly enhanced activity against the proliferation of human cancer cells and inhibit steroid sulphatase (STS), another current oncology target.	2-methoxy-3-o-sulfamoyl estrone	106-137	steroid sulfatase	Homo sapiens	250-268
15862971-1	2005	Sulfamoylated derivatives of the endogenous estrogen metabolite 2-methoxyestradiol (2-MeOE2 (7)), such as 2-methoxy-3-O-sulfamoyl estrone (2-MeOEMATE (1)), display greatly enhanced activity against the proliferation of human cancer cells and inhibit steroid sulphatase (STS), another current oncology target.	2-methoxyoestrone-3-O-sulphamate	139-149	steroid sulfatase	Homo sapiens	250-268
15862971-2	2005	We explore here the effects of steroidal D-ring modification on the activity of such 2-substituted estrogen-3-O-sulfamates in respect of inhibition of tumour cell proliferation and steroid sulphatase.	2-substituted estrogen-3-o-sulfamates	85-122	steroid sulfatase	Homo sapiens	181-199
16399357-1	2005	Human steroid sulfatase (STS) is an enzyme that hydrolyzes several sulfated steroids, such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate, and results in the production of active substances.	estrone sulfate	94-109	steroid sulfatase	Homo sapiens	6-23
16399357-1	2005	Human steroid sulfatase (STS) is an enzyme that hydrolyzes several sulfated steroids, such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate, and results in the production of active substances.	Dehydroepiandrosterone Sulfate	111-141	steroid sulfatase	Homo sapiens	6-23
16399357-1	2005	Human steroid sulfatase (STS) is an enzyme that hydrolyzes several sulfated steroids, such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate, and results in the production of active substances.	cholesteryl sulfate	147-166	steroid sulfatase	Homo sapiens	6-23
15293998-0	2004	2-(1-adamantyl)-4-(thio)chromenone-6-carboxylic acids: potent reversible inhibitors of human steroid sulfatase.	2-(1-adamantyl)-4-(thio)chromenone-6-carboxylic acids	0-53	steroid sulfatase	Homo sapiens	93-110
15544928-0	2004	6-[2-(adamantylidene)-hydroxybenzoxazole]-O-sulfamate, a steroid sulfatase inhibitor for the treatment of androgen- and estrogen-dependent diseases.	6-(2-(adamantylidene)-hydroxybenzoxazole)-O-sulfamate	0-53	steroid sulfatase	Homo sapiens	57-74
15544928-1	2004	Steroid sulfatase (STS) offers a new target for the treatment of steroid hormone-dependent diseases, such as breast and prostate cancer and androgen-dependent skin diseases.	Steroids	65-80	steroid sulfatase	Homo sapiens	0-17
14737345-1	2004	A number of lithium bonding systems (X-LiY) have been found in which the X-Li bond is shortened due to the lithium bond formation.	Lithium	12-19	steroid sulfatase	Homo sapiens	37-41
14969586-3	2004	STS (steroid sulphatase), which is present ubiquitously in mammalian tissues, including the placenta, adrenal gland, testis and ovary, desulphates a number of 3beta-hydroxysteroid sulphates, including cholesterol sulphate.	desulphates	135-146	steroid sulfatase	Homo sapiens	5-23
14969586-3	2004	STS (steroid sulphatase), which is present ubiquitously in mammalian tissues, including the placenta, adrenal gland, testis and ovary, desulphates a number of 3beta-hydroxysteroid sulphates, including cholesterol sulphate.	3beta-hydroxysteroid sulphates	159-189	steroid sulfatase	Homo sapiens	5-23
14969586-3	2004	STS (steroid sulphatase), which is present ubiquitously in mammalian tissues, including the placenta, adrenal gland, testis and ovary, desulphates a number of 3beta-hydroxysteroid sulphates, including cholesterol sulphate.	cholesteryl sulfate	201-221	steroid sulfatase	Homo sapiens	5-23
14684318-0	2004	The difluoromethylene group as a replacement for the labile oxygen in steroid sulfates: a new approach to steroid sulfatase inhibitors.	CID 6432238	4-21	steroid sulfatase	Homo sapiens	106-123
14684318-0	2004	The difluoromethylene group as a replacement for the labile oxygen in steroid sulfates: a new approach to steroid sulfatase inhibitors.	Oxygen	60-66	steroid sulfatase	Homo sapiens	106-123
14684318-0	2004	The difluoromethylene group as a replacement for the labile oxygen in steroid sulfates: a new approach to steroid sulfatase inhibitors.	steroid sulfates	70-86	steroid sulfatase	Homo sapiens	106-123
15110857-0	2004	Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors of steroid sulfatase.	benzophenone	44-56	steroid sulfatase	Homo sapiens	77-94
15056284-2	2004	We investigated steroid sulfatase (STS) in human temporal lobe biopsies in the context of possible cerebral DHEA(S) de novo biosynthesis.	Dehydroepiandrosterone	108-112	steroid sulfatase	Homo sapiens	16-33
15145451-1	2004	A number of 2-phenylindole sulfamates with lipophilic side chains in 1- or 5-position of the indole were synthesized and evaluated as steroid sulfatase (estrone sulfatase) inhibitors.	2-phenylindole	12-26	steroid sulfatase	Homo sapiens	153-170
15145451-1	2004	A number of 2-phenylindole sulfamates with lipophilic side chains in 1- or 5-position of the indole were synthesized and evaluated as steroid sulfatase (estrone sulfatase) inhibitors.	indole	20-26	steroid sulfatase	Homo sapiens	153-170
14741252-0	2004	Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.	alkyl and cycloalkyl ester	40-66	steroid sulfatase	Homo sapiens	14-31
14741252-0	2004	Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.	alkyl and cycloalkyl ester	40-66	steroid sulfatase	Homo sapiens	33-35
14741252-0	2004	Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.	4-[(aminosulfonyl)oxy] benzoic acid	82-117	steroid sulfatase	Homo sapiens	14-31
14741252-0	2004	Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.	4-[(aminosulfonyl)oxy] benzoic acid	82-117	steroid sulfatase	Homo sapiens	33-35
14737345-1	2004	A number of lithium bonding systems (X-LiY) have been found in which the X-Li bond is shortened due to the lithium bond formation.	Lithium	107-114	steroid sulfatase	Homo sapiens	37-41
14643316-0	2003	6-(2-adamantan-2-ylidene-hydroxybenzoxazole)-O-sulfamate: a potent non-steroidal irreversible inhibitor of human steroid sulfatase.	6-(2-adamantan-2-ylidene-hydroxybenzoxazole)-O-sulfamate	0-56	steroid sulfatase	Homo sapiens	113-130
14643316-1	2003	We report the synthesis and results from the in vitro evaluation of 6-(adamantan-2-ylidene-hydroxybenzoxazole)-O-sulfamate 1 as an irreversible inhibitor of human steroid sulfatase (STS).	6-(adamantan-2-ylidene-hydroxybenzoxazole)-o-sulfamate	68-122	steroid sulfatase	Homo sapiens	163-180
14552755-0	2003	Nortropinyl-arylsulfonylureas as novel, reversible inhibitors of human steroid sulfatase.	nortropinyl-arylsulfonylureas	0-29	steroid sulfatase	Homo sapiens	71-88
14741252-1	2004	In our search for potent inhibitors of the enzyme estrone sulfatase (ES), we have undertaken the synthesis and biochemical evaluation of a range of esters of 4-[(aminosulfonyl)oxy] benzoic acid.	Esters	148-154	steroid sulfatase	Homo sapiens	50-67
14741252-1	2004	In our search for potent inhibitors of the enzyme estrone sulfatase (ES), we have undertaken the synthesis and biochemical evaluation of a range of esters of 4-[(aminosulfonyl)oxy] benzoic acid.	Esters	148-154	steroid sulfatase	Homo sapiens	69-71
14741252-1	2004	In our search for potent inhibitors of the enzyme estrone sulfatase (ES), we have undertaken the synthesis and biochemical evaluation of a range of esters of 4-[(aminosulfonyl)oxy] benzoic acid.	4-[(aminosulfonyl)oxy] benzoic acid	158-193	steroid sulfatase	Homo sapiens	50-67
14741252-1	2004	In our search for potent inhibitors of the enzyme estrone sulfatase (ES), we have undertaken the synthesis and biochemical evaluation of a range of esters of 4-[(aminosulfonyl)oxy] benzoic acid.	4-[(aminosulfonyl)oxy] benzoic acid	158-193	steroid sulfatase	Homo sapiens	69-71
14623543-1	2003	Steroid sulfatase (STS) hydrolyzes inactive estrone sulfate (E1-S) to estrone (E1), while estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to estrogen sulfates.	estrone sulfate	44-59	steroid sulfatase	Homo sapiens	0-17
14507642-5	2003	Estrone sulfate (E1S) is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS).	estrone sulfate	0-15	steroid sulfatase	Homo sapiens	134-151
14584960-0	2003	Estrogenic potential of 2-alkyl-4-(thio)chromenone 6-O-sulfamates: potent inhibitors of human steroid sulfatase.	2-alkyl-4-(thio)chromenone 6-o-sulfamates	24-65	steroid sulfatase	Homo sapiens	94-111
14623543-1	2003	Steroid sulfatase (STS) hydrolyzes inactive estrone sulfate (E1-S) to estrone (E1), while estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to estrogen sulfates.	Estrone	44-51	steroid sulfatase	Homo sapiens	0-17
14623543-1	2003	Steroid sulfatase (STS) hydrolyzes inactive estrone sulfate (E1-S) to estrone (E1), while estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to estrogen sulfates.	estrogen sulfates	168-185	steroid sulfatase	Homo sapiens	0-17
12878177-0	2003	The design, synthesis, and in vitro biochemical evaluation of a series of esters of 4-[(aminosulfonyl)oxy]benzoate as novel and highly potent inhibitors of estrone sulfatase.	Esters	74-80	steroid sulfatase	Homo sapiens	156-173
12878177-0	2003	The design, synthesis, and in vitro biochemical evaluation of a series of esters of 4-[(aminosulfonyl)oxy]benzoate as novel and highly potent inhibitors of estrone sulfatase.	4-[(aminosulfonyl)oxy]benzoate	84-114	steroid sulfatase	Homo sapiens	156-173
12878177-1	2003	We report the initial results of our study into the use of a potential transition-state (TS) of the reaction catalysed by the enzyme estrone sulfatase (ES) in the design of a series of cyclic esters of 4-[(aminosulfonyl)oxy]benzoate as novel inhibitors of ES.	cyclic esters	185-198	steroid sulfatase	Homo sapiens	133-150
12878177-1	2003	We report the initial results of our study into the use of a potential transition-state (TS) of the reaction catalysed by the enzyme estrone sulfatase (ES) in the design of a series of cyclic esters of 4-[(aminosulfonyl)oxy]benzoate as novel inhibitors of ES.	4-[(aminosulfonyl)oxy]benzoate	202-232	steroid sulfatase	Homo sapiens	133-150
12900520-5	2003	Treatment of GM-MPhi with a moderate amount of AS-C/EBPbeta not only inhibits the expression of the small isoform of C/EBPbeta preferentially, but also stimulates the induction of Hck and stimulates the virus production at a high rate.	ebpbeta	52-59	steroid sulfatase	Homo sapiens	47-51
12782580-1	2003	Estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to inactive estrogen sulfates, whereas steroid sulfatase (STS) hydrolyzes estrone sulfate to estrone.	estrone sulfate	149-164	steroid sulfatase	Homo sapiens	114-131
12900520-5	2003	Treatment of GM-MPhi with a moderate amount of AS-C/EBPbeta not only inhibits the expression of the small isoform of C/EBPbeta preferentially, but also stimulates the induction of Hck and stimulates the virus production at a high rate.	gm-mphi	13-20	steroid sulfatase	Homo sapiens	47-51
12877744-2	2003	The arsC gene, which codes for an arsenate reductase is essential for arsenate resistance and transforms arsenate into arsenite, which is extruded from the cell.	arsenic acid	34-42	steroid sulfatase	Homo sapiens	4-8
12877744-2	2003	The arsC gene, which codes for an arsenate reductase is essential for arsenate resistance and transforms arsenate into arsenite, which is extruded from the cell.	arsenic acid	70-78	steroid sulfatase	Homo sapiens	4-8
12877744-2	2003	The arsC gene, which codes for an arsenate reductase is essential for arsenate resistance and transforms arsenate into arsenite, which is extruded from the cell.	arsenite	119-127	steroid sulfatase	Homo sapiens	4-8
12877744-3	2003	A survey of GenBank shows that arsC appears to be phylogenetically widespread both in organisms with known arsenic resistance and those organisms that have been sequenced as part of whole genome projects.	Arsenic	107-114	steroid sulfatase	Homo sapiens	31-35
12782580-1	2003	Estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to inactive estrogen sulfates, whereas steroid sulfatase (STS) hydrolyzes estrone sulfate to estrone.	Estrone	149-156	steroid sulfatase	Homo sapiens	114-131
12659755-1	2003	A series of novel D-ring modified derivatives of estrone was synthesized and tested as inhibitors of steroid sulfatase (STS).	Estrone	49-56	steroid sulfatase	Homo sapiens	101-118
12487320-6	2002	Approximately 4.9 x 10(8) t of refuse was disposed in NYC during the 20th century (including commercial and residential refuse), representing a total pool of about 8.0 x 10(7) t of organic carbon (as C) that has entered city landfills and incinerators.	Carbon	189-195	steroid sulfatase	Homo sapiens	197-201
12679736-9	2003	As c-KIT was expressed in 78% of the pancreatic IDCs, it suggests that STI571 may be a beneficial agent for chemotherapy against human pancreatic IDCs.	Imatinib Mesylate	71-77	steroid sulfatase	Homo sapiens	0-4
12475228-0	2002	Estrone 3-sulfate mimics, inhibitors of estrone sulfatase activity: homology model construction and docking studies.	estrone sulfate	0-17	steroid sulfatase	Homo sapiens	40-57
12475228-4	2002	From structure-activity studies, we show that chirality at the phosphorus atom, hydrophobicity, basicity, size, and charge all influence the ability of a compound to inhibit estrone sulfatase activity.	Phosphorus	63-73	steroid sulfatase	Homo sapiens	174-191
12413846-1	2002	Estrone sulfate (E1S) is an endogenous prodrug that delivers estrone and, subsequently, estradiol to the target cells following the hydrolysis by the enzyme estrone sulfatase which is active in various tissues including hormone dependent breast cancer cells.	estrone sulfate	0-15	steroid sulfatase	Homo sapiens	157-174
12413846-1	2002	Estrone sulfate (E1S) is an endogenous prodrug that delivers estrone and, subsequently, estradiol to the target cells following the hydrolysis by the enzyme estrone sulfatase which is active in various tissues including hormone dependent breast cancer cells.	Estrone	61-68	steroid sulfatase	Homo sapiens	157-174
12413846-1	2002	Estrone sulfate (E1S) is an endogenous prodrug that delivers estrone and, subsequently, estradiol to the target cells following the hydrolysis by the enzyme estrone sulfatase which is active in various tissues including hormone dependent breast cancer cells.	Estradiol	88-97	steroid sulfatase	Homo sapiens	157-174
12413846-3	2002	Sulfamates of a variety of phenolic compounds have been shown to be inhibitors of estrone sulfatase.	sulfamic acid	0-10	steroid sulfatase	Homo sapiens	82-99
12466383-3	2002	Estrone sulfate (E1S) is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1), by steroid sulfatase (STS).	estrone sulfate	0-15	steroid sulfatase	Homo sapiens	135-152
12711022-5	2003	Oestrogen sulphamates are potent inhibitors of steroid sulphatase (STS) activity.	oestrogen sulphamates	0-21	steroid sulfatase	Homo sapiens	47-65
12475726-0	2003	Steroidal oxathiazine inhibitors of estrone sulfatase.	1,2,3-Oxathiazine	10-21	steroid sulfatase	Homo sapiens	36-53
12475726-1	2003	The presence of estrone sulfatase in breast tumors and the high levels of circulating estrone sulfate may contribute the major portion of estrogen synthesized locally in breast tissues through conversion of estrone sulfate to estrone by the enzyme.	estrone sulfate	207-222	steroid sulfatase	Homo sapiens	16-33
12475726-3	2003	Therefore, we designed and synthesized several steroidal 2",3"-oxathiazines that inhibit estrone sulfatase and have greatly reduced estrogenic side effects.	2",3"-oxathiazines	57-75	steroid sulfatase	Homo sapiens	89-106
12475726-4	2003	Our in vitro studies indicate that the oxathiazine compounds have inhibitory activity on estrone sulfatase in MCF-7 human breast cancer cells.	1,2,3-Oxathiazine	39-50	steroid sulfatase	Homo sapiens	89-106
12475726-5	2003	These estrone sulfatase inhibitors (ESIs) also inhibit the growth of MCF-7 cells induced by estrone sulfate.	estrone sulfate	92-107	steroid sulfatase	Homo sapiens	6-23
12589950-1	2002	We report the results of our study into a series of 4"-O-sulfamoyl-4-biphenyl based compounds as novel inhibitors of the enzyme estrone sulfatase (ES).	4"-o-sulfamoyl-4-biphenyl based	52-83	steroid sulfatase	Homo sapiens	128-145
12384050-8	2002	The most advantageous configuration tested, where nitrate assimilation (as well as that of ammonium) continued at a high rate in darkness as long as C-reserves remained, is not actually used in migratory species but in non-migratory diatoms.	Nitrates	50-57	steroid sulfatase	Homo sapiens	146-150
12377037-6	2002	Arsenic and selenium extended X-ray absorption fine structure spectroscopy (EXAFS) of the purified species revealed two As-C interactions at 1.943 A and two As-Se interactions at 2.279 A.	Selenium	12-20	steroid sulfatase	Homo sapiens	120-124
12213072-0	2002	2-Substituted 4-(thio)chromenone 6-O-sulfamates: potent inhibitors of human steroid sulfatase.	2-substituted 4-(thio)chromenone 6-o-sulfamates	0-47	steroid sulfatase	Homo sapiens	76-93
12231117-1	2002	The enzyme steryl sulfatase may help support the growth of hormone-dependent tumors, including prostate cancers, by facilitating the conversion of circulating precursor steroids to active hormones.	Steroids	169-177	steroid sulfatase	Homo sapiens	11-27
12161140-0	2002	Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.	4-[(aminosulfonyl)oxy] benzoic acid	55-90	steroid sulfatase	Homo sapiens	14-31
12161140-1	2002	In our search for potent inhibitors of the enzyme estrone sulfatase (ES), we have undertaken the synthesis and biochemical evaluation of a range of straight chain alkyl esters of 4-[(aminosulfonyl)oxy] benzoic acid.	straight chain alkyl esters	148-175	steroid sulfatase	Homo sapiens	50-67
12161140-1	2002	In our search for potent inhibitors of the enzyme estrone sulfatase (ES), we have undertaken the synthesis and biochemical evaluation of a range of straight chain alkyl esters of 4-[(aminosulfonyl)oxy] benzoic acid.	4-[(aminosulfonyl)oxy] benzoic acid	179-214	steroid sulfatase	Homo sapiens	50-67
12231117-3	2002	Intact LNCaP cultures had steryl sulfatase activity, as determined by conversion of [3H]estrone sulfate (E(1)S) to unconjugated steroids.	[6,7-3H] E1S	84-103	steroid sulfatase	Homo sapiens	26-42
12231117-3	2002	Intact LNCaP cultures had steryl sulfatase activity, as determined by conversion of [3H]estrone sulfate (E(1)S) to unconjugated steroids.	Steroids	128-136	steroid sulfatase	Homo sapiens	26-42
12231117-5	2002	The observed activity in both cell lines was blocked by addition of 1 microM estrone sulfamate (EMATE), an active-site-directed, steroidal inhibitor of steryl sulfatase.	estrone-3-O-sulfamate	77-94	steroid sulfatase	Homo sapiens	152-168
12231117-6	2002	Steryl sulfatase activity was also inhibited by Danazol, and by (p-O-sulfamoyl)-tetradecanoyl tyramine (C2-14), a non-steroidal inhibitor.	Danazol	48-55	steroid sulfatase	Homo sapiens	0-16
12231117-6	2002	Steryl sulfatase activity was also inhibited by Danazol, and by (p-O-sulfamoyl)-tetradecanoyl tyramine (C2-14), a non-steroidal inhibitor.	(p-o-sulfamoyl)-tetradecanoyl tyramine	64-102	steroid sulfatase	Homo sapiens	0-16
12231117-6	2002	Steryl sulfatase activity was also inhibited by Danazol, and by (p-O-sulfamoyl)-tetradecanoyl tyramine (C2-14), a non-steroidal inhibitor.	4-O-(sulfamoyl)-N-tetradecanoyltyramine	104-109	steroid sulfatase	Homo sapiens	0-16
12231117-7	2002	Microsomes prepared from LNCaP cultures also showed steryl sulfatase activity, as determined by hydrolysis of [3H]E(1)S and [3H]dehydroepiandrosterone sulfate (DHEAS) to unconjugated forms.	[3h]e(1)s	110-119	steroid sulfatase	Homo sapiens	52-68
12231117-7	2002	Microsomes prepared from LNCaP cultures also showed steryl sulfatase activity, as determined by hydrolysis of [3H]E(1)S and [3H]dehydroepiandrosterone sulfate (DHEAS) to unconjugated forms.	CCG-204473	124-158	steroid sulfatase	Homo sapiens	52-68
12231117-7	2002	Microsomes prepared from LNCaP cultures also showed steryl sulfatase activity, as determined by hydrolysis of [3H]E(1)S and [3H]dehydroepiandrosterone sulfate (DHEAS) to unconjugated forms.	Dehydroepiandrosterone Sulfate	160-165	steroid sulfatase	Homo sapiens	52-68
12231117-9	2002	Hydrolysis of E(1)S in LNCaP and MDA-MB-231 microsomes was blocked by steryl sulfatase inhibitors with the following relative potencies: EMATE>C2-14>Danazol.	Danazol	155-162	steroid sulfatase	Homo sapiens	70-86
11861502-3	2002	Therefore, we investigated the hydrolysis of iodothyronine sulfates by homogenates of V79 cells expressing the human arylsulfatases A (ARSA), B (ARSB), or C (ARSC; steroid sulfatase), as well as tissue fractions of human and rat liver and placenta.	iodothyronine sulfates	45-67	steroid sulfatase	Homo sapiens	158-162
12127511-0	2002	4,4"-Benzophenone-O,O"-disulfamate: a potent inhibitor of steroid sulfatase.	4,4'-Benzophenone-O,O'-disulfamate	0-34	steroid sulfatase	Homo sapiens	58-75
12127511-1	2002	We investigated whether the benzophenone moiety can be used as core element of steroid sulfatase (STS) inhibitors.	benzophenone	28-40	steroid sulfatase	Homo sapiens	79-96
12140258-5	2002	The electrical-field-evoked Ca(2+) response as well as c-Fos activation and growth stimulation of tumor spheroids were inhibited by pretreatment with the anion channel blockers NPPB, niflumic acid and tamoxifen.	5-nitro-2-(3-phenylpropylamino)benzoic acid	177-181	steroid sulfatase	Homo sapiens	52-56
12140258-5	2002	The electrical-field-evoked Ca(2+) response as well as c-Fos activation and growth stimulation of tumor spheroids were inhibited by pretreatment with the anion channel blockers NPPB, niflumic acid and tamoxifen.	Tamoxifen	201-210	steroid sulfatase	Homo sapiens	52-56
12163135-3	2002	Tibolone and its metabolites Org 4094, Org 30126 and Org OM38 have been reported to inhibit estrone sulfatase activity in MCF-7 and T47D breast cancer cell lines, which suggest beneficial effects on hormone dependent breast cancer by reducing local production of free estrogens.	tibolone	0-8	steroid sulfatase	Homo sapiens	92-109
12163135-8	2002	ASC had high sulfatase activity, which was inhibited by 10(-6)M of tibolone, Org 4094 and Org 30126, but not by Org OM38 or Org 2058.	tibolone	67-75	steroid sulfatase	Homo sapiens	0-3
12099869-4	2002	The chiral trisphenol, which contains a stereogenic center (indicated as C in the shorthand notation used above), coordinates titanium in an analogous fashion to produce only one diastereomer (out of four possible); therefore, the configuration of the stereogenic center controls the conformation adopted by the bound ligand.	trisphenol	11-21	steroid sulfatase	Homo sapiens	70-74
12099869-4	2002	The chiral trisphenol, which contains a stereogenic center (indicated as C in the shorthand notation used above), coordinates titanium in an analogous fashion to produce only one diastereomer (out of four possible); therefore, the configuration of the stereogenic center controls the conformation adopted by the bound ligand.	Titanium	126-134	steroid sulfatase	Homo sapiens	70-74
12163135-0	2002	Effect of tibolone (Org OD14) and its metabolites on aromatase and estrone sulfatase activity in human breast adipose stromal cells and in MCF-7 and T47D breast cancer cells.	tibolone	10-18	steroid sulfatase	Homo sapiens	67-84
12054760-0	2002	The design, synthesis, and biochemical evaluation of derivatives of biphenyl sulfamate-based compounds as novel inhibitors of estrone sulfatase.	biphenyl sulfamate	68-86	steroid sulfatase	Homo sapiens	126-143
11965370-0	2002	The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds.	Methane	111-118	steroid sulfatase	Homo sapiens	48-65
11965370-0	2002	The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds.	Methane	111-118	steroid sulfatase	Homo sapiens	67-69
11965370-0	2002	The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds.	and amino-sulfonate	120-139	steroid sulfatase	Homo sapiens	48-65
11965370-0	2002	The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds.	and amino-sulfonate	120-139	steroid sulfatase	Homo sapiens	67-69
11965370-1	2002	We report the results of our study into a series of simple phenyl and alkyl sulfamates and alkyl methanesulfonates as potential inhibitors of the enzyme estrone sulfatase (ES).	simple	52-58	steroid sulfatase	Homo sapiens	153-170
11965370-1	2002	We report the results of our study into a series of simple phenyl and alkyl sulfamates and alkyl methanesulfonates as potential inhibitors of the enzyme estrone sulfatase (ES).	simple	52-58	steroid sulfatase	Homo sapiens	172-174
11965370-1	2002	We report the results of our study into a series of simple phenyl and alkyl sulfamates and alkyl methanesulfonates as potential inhibitors of the enzyme estrone sulfatase (ES).	phenyl and alkyl sulfamates	59-86	steroid sulfatase	Homo sapiens	153-170
11965370-1	2002	We report the results of our study into a series of simple phenyl and alkyl sulfamates and alkyl methanesulfonates as potential inhibitors of the enzyme estrone sulfatase (ES).	phenyl and alkyl sulfamates	59-86	steroid sulfatase	Homo sapiens	172-174
11965370-1	2002	We report the results of our study into a series of simple phenyl and alkyl sulfamates and alkyl methanesulfonates as potential inhibitors of the enzyme estrone sulfatase (ES).	alkyl methanesulfonates	91-114	steroid sulfatase	Homo sapiens	153-170
11965370-1	2002	We report the results of our study into a series of simple phenyl and alkyl sulfamates and alkyl methanesulfonates as potential inhibitors of the enzyme estrone sulfatase (ES).	alkyl methanesulfonates	91-114	steroid sulfatase	Homo sapiens	172-174
11965370-3	2002	Using the results of the inhibition study, we postulate the probable mechanism for ES and suggest that an attack by the gem-diol is a major requirement prior to the hydrolysis of the sulfamate group, following which, attack on the active site C=O occurs and which therefore leads to the production of an imine type functionality, resulting in irreversible inhibition.	gem-diol	120-128	steroid sulfatase	Homo sapiens	83-85
11965370-3	2002	Using the results of the inhibition study, we postulate the probable mechanism for ES and suggest that an attack by the gem-diol is a major requirement prior to the hydrolysis of the sulfamate group, following which, attack on the active site C=O occurs and which therefore leads to the production of an imine type functionality, resulting in irreversible inhibition.	sulfamic acid	183-192	steroid sulfatase	Homo sapiens	83-85
11965370-3	2002	Using the results of the inhibition study, we postulate the probable mechanism for ES and suggest that an attack by the gem-diol is a major requirement prior to the hydrolysis of the sulfamate group, following which, attack on the active site C=O occurs and which therefore leads to the production of an imine type functionality, resulting in irreversible inhibition.	Imines	304-309	steroid sulfatase	Homo sapiens	83-85
11861502-5	2002	Among the recombinant enzymes only the endoplasmic reticulum-associated ARSC showed activity toward iodothyronine sulfates; the soluble lysosomal ARSA and ARSB were inactive.	iodothyronine sulfates	100-122	steroid sulfatase	Homo sapiens	72-76
11549461-1	2001	We report the initial structure-activity relationship study (SAR) (in particular logP) of a series of compounds based upon 4-sulfamated phenyl ketones as potent inhibitors of the enzyme estrone sulfatase (ES).	benzophenone	136-150	steroid sulfatase	Homo sapiens	186-203
11870235-1	2002	The aim of this study was to characterize the mechanism of the chemical interaction between L-ascorbic acid (ASC) and tetrahydrobiopterin (BH(4)) in vitro and to examine its effect on the activity of endothelial nitric oxide synthase (eNOS) in first trimester human placentae.	Ascorbic Acid	92-107	steroid sulfatase	Homo sapiens	109-112
11870235-1	2002	The aim of this study was to characterize the mechanism of the chemical interaction between L-ascorbic acid (ASC) and tetrahydrobiopterin (BH(4)) in vitro and to examine its effect on the activity of endothelial nitric oxide synthase (eNOS) in first trimester human placentae.	sapropterin	118-137	steroid sulfatase	Homo sapiens	109-112
11870235-2	2002	At room temperature, in Tris-HCl buffer (pH 7.4), both ASC and BH(4) were readily oxidized by dissolved O(2) or H(2)O(2).	Tris hydrochloride	24-32	steroid sulfatase	Homo sapiens	55-58
11870235-2	2002	At room temperature, in Tris-HCl buffer (pH 7.4), both ASC and BH(4) were readily oxidized by dissolved O(2) or H(2)O(2).	o(2)	104-108	steroid sulfatase	Homo sapiens	55-58
11870235-2	2002	At room temperature, in Tris-HCl buffer (pH 7.4), both ASC and BH(4) were readily oxidized by dissolved O(2) or H(2)O(2).	Water	112-117	steroid sulfatase	Homo sapiens	55-58
11870235-4	2002	Addition of 36 micromol/l BH(4) to 143 micromol/l ASC increased the initial rate of ASC oxidation 3.2-fold in a catalase-sensitive manner, indicating that enhanced ASC oxidation is partly due to the formation of H(2)O(2).	Water	212-217	steroid sulfatase	Homo sapiens	50-53
11870235-4	2002	Addition of 36 micromol/l BH(4) to 143 micromol/l ASC increased the initial rate of ASC oxidation 3.2-fold in a catalase-sensitive manner, indicating that enhanced ASC oxidation is partly due to the formation of H(2)O(2).	Water	212-217	steroid sulfatase	Homo sapiens	84-87
11870235-4	2002	Addition of 36 micromol/l BH(4) to 143 micromol/l ASC increased the initial rate of ASC oxidation 3.2-fold in a catalase-sensitive manner, indicating that enhanced ASC oxidation is partly due to the formation of H(2)O(2).	Water	212-217	steroid sulfatase	Homo sapiens	84-87
11870235-9	2002	Moreover, we demonstrated that concentrations of ASC present in the placenta as a common vitamin C supply are sufficient to protect cellular free BH(4) and may contribute to the stimulation of placental eNOS activity.	Ascorbic Acid	89-98	steroid sulfatase	Homo sapiens	49-52
11520136-1	2001	OBJECTIVE: Steroid sulfatase (STS) is an important enzyme that converts biological inactive steroid sulfate to active free steroid.	steroid sulfate	92-107	steroid sulfatase	Homo sapiens	11-28
11520136-1	2001	OBJECTIVE: Steroid sulfatase (STS) is an important enzyme that converts biological inactive steroid sulfate to active free steroid.	Steroids	92-99	steroid sulfatase	Homo sapiens	11-28
11277533-1	2001	We report the initial results of our study into a series of simple 4-sulfamated phenyl alkyl ketones as potential inhibitors of the enzyme estrone sulfatase.	phenyl alkyl ketones	80-100	steroid sulfatase	Homo sapiens	139-156
11389190-5	2001	In progenitors the activation of p42/44-mitogen-activated protein kinase (MAPK) and cAMP-response element binding protein (CREB) as well as c-fos mRNA expression were blocked by the M3 relatively selective antagonist, 4-DAMP, and its irreversible analogue, 4-DAMP-mustard.	4-diphenylacetoxy-1,1-dimethylpiperidinium	218-224	steroid sulfatase	Homo sapiens	137-141
11393448-7	2001	By comparing the noise level of the observed image and the gray scale of single atoms such as C, Si, S, Cu, and Au, we verified that the Si and S atoms have almost twice as large contrast as the noise (peak-to-peak), and C atoms have almost the same contrast as the noise level.	Silicon	137-139	steroid sulfatase	Homo sapiens	91-95
11580336-4	2001	As c increases from the bct ground state, the local field initially decreases rapidly towards the isotropic value at the body-centered cubic lattice, decreases further, reaching a minimum value and increases, passing through the isotropic value again at an intermediate lattice, reaches a maximum value and finally decreases to the fcc value.	Bicarbonates	24-27	steroid sulfatase	Homo sapiens	0-4
11070351-0	2000	Stimulation of MCF-7 breast cancer cell proliferation by estrone sulfate and dehydroepiandrosterone sulfate: inhibition by novel non-steroidal steroid sulfatase inhibitors.	estrone sulfate	57-72	steroid sulfatase	Homo sapiens	143-160
11282280-1	2000	Steroid sulphatase (STS) catalyzes the conversion of oestrone sulphate (E1S) to oestrone (E1) and its action in breast tumours makes a major contribution to in situ oestrogen production in this tissue.	estrone sulfate	53-70	steroid sulfatase	Homo sapiens	0-18
11282280-1	2000	Steroid sulphatase (STS) catalyzes the conversion of oestrone sulphate (E1S) to oestrone (E1) and its action in breast tumours makes a major contribution to in situ oestrogen production in this tissue.	Estrone	72-75	steroid sulfatase	Homo sapiens	0-18
11282280-1	2000	Steroid sulphatase (STS) catalyzes the conversion of oestrone sulphate (E1S) to oestrone (E1) and its action in breast tumours makes a major contribution to in situ oestrogen production in this tissue.	Estrone	53-61	steroid sulfatase	Homo sapiens	0-18
11087571-1	2000	The steroid sulfatase or steryl sulfatase is a microsomal enzyme widely distributed in human tissues that catalyzes the hydrolysis of sulfated 3-hydroxy steroids to the corresponding free active 3-hydroxy steroids.	3-hydroxy steroids	143-161	steroid sulfatase	Homo sapiens	25-41
11087571-1	2000	The steroid sulfatase or steryl sulfatase is a microsomal enzyme widely distributed in human tissues that catalyzes the hydrolysis of sulfated 3-hydroxy steroids to the corresponding free active 3-hydroxy steroids.	3-hydroxy steroids	195-213	steroid sulfatase	Homo sapiens	25-41
11072818-7	2000	HCl adds readily to one of its As-C bonds without opening it.	Hydrochloric Acid	0-3	steroid sulfatase	Homo sapiens	31-35
11070351-0	2000	Stimulation of MCF-7 breast cancer cell proliferation by estrone sulfate and dehydroepiandrosterone sulfate: inhibition by novel non-steroidal steroid sulfatase inhibitors.	Dehydroepiandrosterone Sulfate	77-107	steroid sulfatase	Homo sapiens	143-160
11070351-1	2000	Steroid sulfatase (STS) regulates the formation of active steroids from systemic precursors, such as estrone sulfate and dehydroepiandrosterone sulfate (DHEAS).	Steroids	58-66	steroid sulfatase	Homo sapiens	0-17
11070351-1	2000	Steroid sulfatase (STS) regulates the formation of active steroids from systemic precursors, such as estrone sulfate and dehydroepiandrosterone sulfate (DHEAS).	estrone sulfate	101-116	steroid sulfatase	Homo sapiens	0-17
11070351-1	2000	Steroid sulfatase (STS) regulates the formation of active steroids from systemic precursors, such as estrone sulfate and dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	121-151	steroid sulfatase	Homo sapiens	0-17
11070351-1	2000	Steroid sulfatase (STS) regulates the formation of active steroids from systemic precursors, such as estrone sulfate and dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	153-158	steroid sulfatase	Homo sapiens	0-17
10833455-0	2000	First report of the investigation into the importance of pK(a) in the inhibition of estrone sulfatase by sulfamate containing compounds.	sulfamic acid	105-114	steroid sulfatase	Homo sapiens	84-101
11060442-1	2000	Steroid sulfatase (STS, EC 3.1.6.2) catalyzes the hydrolysis of the sulfate ester bonds of a variety of sulfated steroids, such as cholesterol, dehydroepiandrosterone, and estrone sulfate, a reaction influencing fertility and breast cancer in mammals.	sulfate ester	68-81	steroid sulfatase	Homo sapiens	0-17
10794276-8	2000	Half-normal probability plots show that the largest geometric differences, within the metal complex, are in the bond and torsion angles around the As-C bonds.	Metals	86-91	steroid sulfatase	Homo sapiens	147-151
10711632-1	2000	The effect of monovalent cation on the activity of the XL-I and XL-III forms of xenobiotic/medium-chain fatty acid:CoA ligase (XM-ligase) was investigated using a variety of different carboxylic acid substrates.	medium-chain fatty acid	91-114	steroid sulfatase	Homo sapiens	55-59
10711632-1	2000	The effect of monovalent cation on the activity of the XL-I and XL-III forms of xenobiotic/medium-chain fatty acid:CoA ligase (XM-ligase) was investigated using a variety of different carboxylic acid substrates.	Carboxylic Acids	184-199	steroid sulfatase	Homo sapiens	55-59
10711632-2	2000	With benzoate or p-hydroxybenzoate as substrate, the XL-I ligase was essentially inactive in the absence of monovalent cation.	Benzoates	5-13	steroid sulfatase	Homo sapiens	53-57
10711632-2	2000	With benzoate or p-hydroxybenzoate as substrate, the XL-I ligase was essentially inactive in the absence of monovalent cation.	4-hydroxybenzoic acid	17-34	steroid sulfatase	Homo sapiens	53-57
10731640-3	2000	Estrone sulfate (E(1)-S) is the predominant estrogen of conjugated equiline estrogens, which is commonly used in hormone replacement therapy, but it should be hydrolyzed by steroid sulfatase (STS) to enter the cells of target tissues.	estrone sulfate	0-15	steroid sulfatase	Homo sapiens	173-190
10731640-3	2000	Estrone sulfate (E(1)-S) is the predominant estrogen of conjugated equiline estrogens, which is commonly used in hormone replacement therapy, but it should be hydrolyzed by steroid sulfatase (STS) to enter the cells of target tissues.	Estrone	17-23	steroid sulfatase	Homo sapiens	173-190
10731640-3	2000	Estrone sulfate (E(1)-S) is the predominant estrogen of conjugated equiline estrogens, which is commonly used in hormone replacement therapy, but it should be hydrolyzed by steroid sulfatase (STS) to enter the cells of target tissues.	EQUILINE	67-75	steroid sulfatase	Homo sapiens	173-190
10593884-0	1999	Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction.	Hydrogen	103-111	steroid sulfatase	Homo sapiens	121-125
10593884-0	1999	Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction.	arsenic acid	136-144	steroid sulfatase	Homo sapiens	121-125
10593884-1	1999	In Escherichia coli ArsC catalyzes the reduction of arsenate to arsenite using GSH with glutaredoxin as electron donors.	arsenic acid	52-60	steroid sulfatase	Homo sapiens	20-24
10593884-1	1999	In Escherichia coli ArsC catalyzes the reduction of arsenate to arsenite using GSH with glutaredoxin as electron donors.	arsenite	64-72	steroid sulfatase	Homo sapiens	20-24
10593884-1	1999	In Escherichia coli ArsC catalyzes the reduction of arsenate to arsenite using GSH with glutaredoxin as electron donors.	Glutathione	79-82	steroid sulfatase	Homo sapiens	20-24
10593884-4	1999	In this report glutaredoxin 2 is shown to be the most effective hydrogen donor for the reduction of arsenate by ArsC.	Hydrogen	64-72	steroid sulfatase	Homo sapiens	112-116
10593884-4	1999	In this report glutaredoxin 2 is shown to be the most effective hydrogen donor for the reduction of arsenate by ArsC.	arsenic acid	100-108	steroid sulfatase	Homo sapiens	112-116
10593884-6	1999	This suggests that, during the catalytic cycle, ArsC forms a mixed disulfide with GSH before being reduced by glutaredoxin to regenerate the active ArsC reductase.	Disulfides	67-76	steroid sulfatase	Homo sapiens	48-52
10593884-6	1999	This suggests that, during the catalytic cycle, ArsC forms a mixed disulfide with GSH before being reduced by glutaredoxin to regenerate the active ArsC reductase.	Disulfides	67-76	steroid sulfatase	Homo sapiens	148-152
10593884-6	1999	This suggests that, during the catalytic cycle, ArsC forms a mixed disulfide with GSH before being reduced by glutaredoxin to regenerate the active ArsC reductase.	Glutathione	82-85	steroid sulfatase	Homo sapiens	48-52
10593884-6	1999	This suggests that, during the catalytic cycle, ArsC forms a mixed disulfide with GSH before being reduced by glutaredoxin to regenerate the active ArsC reductase.	Glutathione	82-85	steroid sulfatase	Homo sapiens	148-152
10736251-2	2000	16alpha-hydroxy dehydroepiandrosterone sulphate (16alpha-OH-DHEAS) is formed in the fetal liver by hydroxylation of dehydroepiandrosterone sulphate (DHEAS) and transported to the placenta where it undergoes desulphation by steroid sulphatase (STS) and aromatization to oestriol.	16-hydroxydehydroepiandrosterone sulfate	0-47	steroid sulfatase	Homo sapiens	223-241
10736251-2	2000	16alpha-hydroxy dehydroepiandrosterone sulphate (16alpha-OH-DHEAS) is formed in the fetal liver by hydroxylation of dehydroepiandrosterone sulphate (DHEAS) and transported to the placenta where it undergoes desulphation by steroid sulphatase (STS) and aromatization to oestriol.	Dehydroepiandrosterone Sulfate	16-47	steroid sulfatase	Homo sapiens	223-241
11060442-1	2000	Steroid sulfatase (STS, EC 3.1.6.2) catalyzes the hydrolysis of the sulfate ester bonds of a variety of sulfated steroids, such as cholesterol, dehydroepiandrosterone, and estrone sulfate, a reaction influencing fertility and breast cancer in mammals.	Steroids	113-121	steroid sulfatase	Homo sapiens	0-17
11060442-1	2000	Steroid sulfatase (STS, EC 3.1.6.2) catalyzes the hydrolysis of the sulfate ester bonds of a variety of sulfated steroids, such as cholesterol, dehydroepiandrosterone, and estrone sulfate, a reaction influencing fertility and breast cancer in mammals.	Cholesterol	131-142	steroid sulfatase	Homo sapiens	0-17
11060442-1	2000	Steroid sulfatase (STS, EC 3.1.6.2) catalyzes the hydrolysis of the sulfate ester bonds of a variety of sulfated steroids, such as cholesterol, dehydroepiandrosterone, and estrone sulfate, a reaction influencing fertility and breast cancer in mammals.	Dehydroepiandrosterone	144-166	steroid sulfatase	Homo sapiens	0-17
11060442-1	2000	Steroid sulfatase (STS, EC 3.1.6.2) catalyzes the hydrolysis of the sulfate ester bonds of a variety of sulfated steroids, such as cholesterol, dehydroepiandrosterone, and estrone sulfate, a reaction influencing fertility and breast cancer in mammals.	estrone sulfate	172-187	steroid sulfatase	Homo sapiens	0-17
9873454-0	1998	17 alpha-alkyl- or 17 alpha-substituted benzyl-17 beta-estradiols: a new family of estrone-sulfatase inhibitors.	17 alpha-alkyl- or 17 alpha-substituted benzyl-17 beta-estradiols	0-65	steroid sulfatase	Homo sapiens	83-100
10447965-7	1999	OMATE potently inhibited estrone sulfatase (E1-STS) activity and was similar to EMATE (>99% inhibition at 0.1 microM in MCF-7 breast cancer cells).	OMATE	0-5	steroid sulfatase	Homo sapiens	25-42
10215035-0	1999	Development of (p-O-sulfamoyl)-N-alkanoyl-phenylalkyl amines as non-steroidal estrone sulfatase inhibitors.	(p-o-sulfamoyl)-n-alkanoyl-phenylalkyl amines	15-60	steroid sulfatase	Homo sapiens	78-95
10215035-2	1999	The major source of estrogen in breast cancer cells may be conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.	estrone sulfate	73-88	steroid sulfatase	Homo sapiens	114-131
10215035-2	1999	The major source of estrogen in breast cancer cells may be conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.	Estrone	73-80	steroid sulfatase	Homo sapiens	114-131
10215035-4	1999	Several steroidal compounds have been developed that are potent estrone sulfatase inhibitors, most notably estrone-3-O-sulfamate.	estrone-3-O-sulfamate	107-128	steroid sulfatase	Homo sapiens	64-81
10215035-6	1999	To avoid the problems associated with a potentially active steroid nucleus, we designed and synthesized a series of nonsteroidal estrone sulfatase inhibitors, the (p-O-sulfamoyl)-N-alkanoyl phenylalkyl amines.	Steroids	59-66	steroid sulfatase	Homo sapiens	129-146
10215035-6	1999	To avoid the problems associated with a potentially active steroid nucleus, we designed and synthesized a series of nonsteroidal estrone sulfatase inhibitors, the (p-O-sulfamoyl)-N-alkanoyl phenylalkyl amines.	(p-o-sulfamoyl)-n-alkanoyl phenylalkyl amines	163-208	steroid sulfatase	Homo sapiens	129-146
10215035-16	1999	Our data indicate the utility of (p-O-sulfamoyl)-N-alkanoyl phenyl alkylamines for inhibition of estrone sulfatase activity.	(p-o-sulfamoyl)-n-alkanoyl phenyl alkylamines	33-78	steroid sulfatase	Homo sapiens	97-114
9920822-1	1999	We report the initial results of a series of molecular modelling studies to investigate the structural properties of non-steroidal inhibitors required for inhibitory activity against the enzyme estrone sulfatase (ES) [the enzyme responsible for the conversion of nonactive (sulfated) estrone to the active (nonsulfated) estrone].	Estrone	284-291	steroid sulfatase	Homo sapiens	194-211
9927050-1	1999	Steroid sulfatase (STS) hydrolyzes several sulfated steroids such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate.	Steroids	52-60	steroid sulfatase	Homo sapiens	0-17
9927050-1	1999	Steroid sulfatase (STS) hydrolyzes several sulfated steroids such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate.	estrone sulfate	69-84	steroid sulfatase	Homo sapiens	0-17
9927050-1	1999	Steroid sulfatase (STS) hydrolyzes several sulfated steroids such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate.	Dehydroepiandrosterone Sulfate	86-116	steroid sulfatase	Homo sapiens	0-17
9927050-1	1999	Steroid sulfatase (STS) hydrolyzes several sulfated steroids such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate.	cholesteryl sulfate	122-141	steroid sulfatase	Homo sapiens	0-17
10092953-1	1999	The enzyme steroid sulfatase (STS) hydrolyses 3-beta-hydroxysteroid sulfates.	3-beta-hydroxysteroid sulfates	46-76	steroid sulfatase	Homo sapiens	11-28
9873454-1	1998	A series of 17 alpha-derivatives of 17 beta-estradiol was synthesized and tested for their ability to inhibit the estrone-sulfatase activity transforming estrone sulfate to estrone.	Estradiol	36-53	steroid sulfatase	Homo sapiens	114-131
9873454-1	1998	A series of 17 alpha-derivatives of 17 beta-estradiol was synthesized and tested for their ability to inhibit the estrone-sulfatase activity transforming estrone sulfate to estrone.	estrone sulfate	154-169	steroid sulfatase	Homo sapiens	114-131
9873454-3	1998	The 17 alpha-(3"-bromobenzyl)-estradiol (26) and 17 alpha-(4"-t-butylbenzyl)-estradiol (30) were the most potent estrone-sulfatase inhibitors obtained in our study with IC50 values of 24 and 28 nM, respectively.	17 alpha-(3"-bromobenzyl)-estradiol	4-39	steroid sulfatase	Homo sapiens	113-130
9873454-3	1998	The 17 alpha-(3"-bromobenzyl)-estradiol (26) and 17 alpha-(4"-t-butylbenzyl)-estradiol (30) were the most potent estrone-sulfatase inhibitors obtained in our study with IC50 values of 24 and 28 nM, respectively.	17 alpha-(4"-t-butylbenzyl)-estradiol	49-86	steroid sulfatase	Homo sapiens	113-130
9635147-4	1998	These findings indicate that relatively minor modifications in the chemical structure of classical steroid sulfamates can preserve or enhance their estrone sulfatase inhibiting properties and, simultaneously, amplify their antioxidant capacity to a great extent.	Steroids	99-106	steroid sulfatase	Homo sapiens	148-165
9654650-2	1998	The major source of estrogen in breast cancer cells may be conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.	estrone sulfate	73-88	steroid sulfatase	Homo sapiens	114-131
9654650-2	1998	The major source of estrogen in breast cancer cells may be conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.	Estrone	73-80	steroid sulfatase	Homo sapiens	114-131
9654650-4	1998	Several steroidal agents have been developed that are potent estrone sulfatase inhibitors, most notably estrone-3-O-sulfamate.	estrone-3-O-sulfamate	104-125	steroid sulfatase	Homo sapiens	61-78
9654650-6	1998	Recently, non-steroidal estrone sulfatase inhibitors have been designed that avoid the problems associated with an active steroid nucleus; however, these have not achieved the potency of estrone-3-O sulfamate.	Steroids	14-21	steroid sulfatase	Homo sapiens	24-41
9635147-5	1998	Taken together, our data suggest that scavestrogen sulfamates such as J 1025, J 1051, or J 1054 (17 beta-dihydroequilenin sulfamate) may serve as a very promising basis for the development of steroid-derived estrone sulfate-sulfatase inhibitors characterized by promising estrone sulfatase inhibiting activities in combination with a "good" antioxidant potency.	scavestrogen sulfamates	38-61	steroid sulfatase	Homo sapiens	272-289
9635147-5	1998	Taken together, our data suggest that scavestrogen sulfamates such as J 1025, J 1051, or J 1054 (17 beta-dihydroequilenin sulfamate) may serve as a very promising basis for the development of steroid-derived estrone sulfate-sulfatase inhibitors characterized by promising estrone sulfatase inhibiting activities in combination with a "good" antioxidant potency.	dihydroequilenin sulfamate	105-131	steroid sulfatase	Homo sapiens	272-289
11666872-4	1996	For the series (CH(3))(3)As, (CH(3))(2)AsF, CH(3)AsF(2), and AsF(3), both As-C and As-F bond lengths are shortened with increasing numbers of F atoms, but the angles CAsF and FAsF are almost invariant.	Arsenic	25-27	steroid sulfatase	Homo sapiens	74-78
9271073-4	1997	ArsA, ArsB, and ArsC form a protein pump system that extrudes antimonite, arsenite, and arsenate once these anions reach the cytoplasm of the bacterium.	arsenite	74-82	steroid sulfatase	Homo sapiens	16-20
9271073-4	1997	ArsA, ArsB, and ArsC form a protein pump system that extrudes antimonite, arsenite, and arsenate once these anions reach the cytoplasm of the bacterium.	arsenic acid	88-96	steroid sulfatase	Homo sapiens	16-20
9090794-0	1997	Estrone sulfonates as inhibitors of estrone sulfatase.	estrone sulfonates	0-18	steroid sulfatase	Homo sapiens	36-53
9090794-1	1997	In our continuing quest to design efficient inhibitors of estrone sulfatase activity and to assess the recognition of estrone sulfate surrogates by estrone sulfatase, we synthesized and evaluated several sulfonate derivatives of 5,6,7,8-tetrahydronaphth-2-ol and estrone.	estrone sulfate	118-133	steroid sulfatase	Homo sapiens	148-165
9044848-0	1997	Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines.	(p-o-sulfamoyl)-n-alkanoyl tyramines	95-131	steroid sulfatase	Homo sapiens	14-31
9044848-2	1997	The major source of estrogen in breast cancer cells may be the conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.	estrone sulfate	77-92	steroid sulfatase	Homo sapiens	118-135
9044848-2	1997	The major source of estrogen in breast cancer cells may be the conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.	Estrone	77-84	steroid sulfatase	Homo sapiens	118-135
9044848-4	1997	Several steroidal agents have been developed that are potent estrone sulfatase inhibitors, most notably estrone-3-O-sulfamate.	estrone-3-O-sulfamate	104-125	steroid sulfatase	Homo sapiens	61-78
9044848-6	1997	To avoid the problems associated with a potentially active steroid nucleus, we designed and synthesized a series of (p-O-sulfamoyl)-N-alkanoyl tyramines as nonsteroidal estrone sulfatase inhibitors.	Steroids	59-66	steroid sulfatase	Homo sapiens	169-186
9044848-6	1997	To avoid the problems associated with a potentially active steroid nucleus, we designed and synthesized a series of (p-O-sulfamoyl)-N-alkanoyl tyramines as nonsteroidal estrone sulfatase inhibitors.	(p-o-sulfamoyl)-n-alkanoyl tyramines	116-152	steroid sulfatase	Homo sapiens	169-186
9044848-8	1997	We tested the ability of the (p-O-sulfamoyl)-N-alkanoyl tyramines to inhibit: (a) estrone sulfatase activity in intact cultures of human breast cancer cells (MDA-MB-231); and (b) the growth of estrogen-dependent human breast cancer cells (MCF-7).	(p-o-sulfamoyl)-n-alkanoyl tyramines	29-65	steroid sulfatase	Homo sapiens	82-99
9044848-9	1997	All of the test compounds (1 microM) inhibited the estrone sulfatase activity of intact MDA-MB-231 cells; however, compounds with a longer alkanoyl chain were more effective than those with a shorter chain.	alkanoyl	139-147	steroid sulfatase	Homo sapiens	51-68
9044848-10	1997	Dose-response analysis indicated an IC50 of 350 nM for (p-O-sulfamoyl)-N-tetradecanoyl tyramine for the inhibition of MDA-MB-231 estrone sulfatase activity.	(p-o-sulfamoyl)-n-tetradecanoyl tyramine	55-95	steroid sulfatase	Homo sapiens	129-146
9044848-15	1997	Our data indicate the utility of (p-O-sulfamoyl)-N-alkanoyl tyramines for the inhibition of breast cancer cell estrone sulfatase activity.	(p-o-sulfamoyl)-n-alkanoyl tyramines	33-69	steroid sulfatase	Homo sapiens	111-128
9389570-7	1997	Dex-induced AS-c-myc RNA resulted in 50% growth inhibition during the first 48 hr, which declined to 25% at 72 hr.	Dextromethorphan	0-3	steroid sulfatase	Homo sapiens	12-16
9449200-0	1997	Inhibition of estrone sulfatase in human liver microsomes by quercetin and other flavonoids.	Quercetin	61-70	steroid sulfatase	Homo sapiens	14-31
9449200-0	1997	Inhibition of estrone sulfatase in human liver microsomes by quercetin and other flavonoids.	Flavonoids	81-91	steroid sulfatase	Homo sapiens	14-31
9449200-4	1997	The natural flavonoids, quercetin, kaempferol, and naringenin, significantly inhibited estrone sulfatase activity with I50 < 10 microM for the most potent, quercetin.	Flavonoids	12-22	steroid sulfatase	Homo sapiens	87-104
9449200-4	1997	The natural flavonoids, quercetin, kaempferol, and naringenin, significantly inhibited estrone sulfatase activity with I50 < 10 microM for the most potent, quercetin.	Quercetin	24-33	steroid sulfatase	Homo sapiens	87-104
9449200-4	1997	The natural flavonoids, quercetin, kaempferol, and naringenin, significantly inhibited estrone sulfatase activity with I50 < 10 microM for the most potent, quercetin.	kaempferol	35-45	steroid sulfatase	Homo sapiens	87-104
9449200-4	1997	The natural flavonoids, quercetin, kaempferol, and naringenin, significantly inhibited estrone sulfatase activity with I50 < 10 microM for the most potent, quercetin.	naringenin	51-61	steroid sulfatase	Homo sapiens	87-104
9449200-4	1997	The natural flavonoids, quercetin, kaempferol, and naringenin, significantly inhibited estrone sulfatase activity with I50 < 10 microM for the most potent, quercetin.	Quercetin	159-168	steroid sulfatase	Homo sapiens	87-104
9449200-7	1997	Quercetin, a natural dietary constituent, is a potent inhibitor of estrone sulfatase in vitro, and thus has the potential to express antiestrogenic activity in vivo.	Quercetin	0-9	steroid sulfatase	Homo sapiens	67-84
8991852-8	1996	The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As(V)] to arsenite [As(III)], the substrate of the efflux system.	Arsenic	22-29	steroid sulfatase	Homo sapiens	49-53
8991852-8	1996	The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As(V)] to arsenite [As(III)], the substrate of the efflux system.	arsenic acid	101-109	steroid sulfatase	Homo sapiens	49-53
8991852-8	1996	The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As(V)] to arsenite [As(III)], the substrate of the efflux system.	asunaprevir	111-116	steroid sulfatase	Homo sapiens	49-53
8991852-8	1996	The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As(V)] to arsenite [As(III)], the substrate of the efflux system.	arsenite	121-129	steroid sulfatase	Homo sapiens	49-53
8991852-8	1996	The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As(V)] to arsenite [As(III)], the substrate of the efflux system.	as(iii)	131-138	steroid sulfatase	Homo sapiens	49-53
8918978-3	1996	In the present study we explored the effect of the progestin, nomegestrol acetate, on the estrone sulfatase and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activities of MCF-7 and T-47D human breast cancer cells.	nomegestrol acetate	62-81	steroid sulfatase	Homo sapiens	90-107
8918978-10	1996	It is concluded that nomegestrol acetate in the hormone-dependent MCF-7 and T-47D breast cancer cells significantly inhibits the estrone sulfatase and 17beta-HSD activities which converts E1S to the biologically active estrogen estradiol.	nomegestrol acetate	21-40	steroid sulfatase	Homo sapiens	129-146
9009241-2	1996	Several lines of evidence indicate that the major source of estrogen in breast cancer cells may be from conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.	estrone sulfate	118-133	steroid sulfatase	Homo sapiens	159-176
9009241-2	1996	Several lines of evidence indicate that the major source of estrogen in breast cancer cells may be from conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.	Estrone	118-125	steroid sulfatase	Homo sapiens	159-176
8918978-10	1996	It is concluded that nomegestrol acetate in the hormone-dependent MCF-7 and T-47D breast cancer cells significantly inhibits the estrone sulfatase and 17beta-HSD activities which converts E1S to the biologically active estrogen estradiol.	Estradiol	228-237	steroid sulfatase	Homo sapiens	129-146
8900573-6	1995	Arsenate (AsV) is converted to arsenite by a soluble reductase (ArsC).	arsenic acid	0-8	steroid sulfatase	Homo sapiens	64-68
8712728-10	1996	The effect of AS c-myc pretreatment on cDDP resistance was not mediated by changes in cell cycle distribution.	Cisplatin	39-43	steroid sulfatase	Homo sapiens	14-18
8905098-11	1996	The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As (V)] to arsenite [As (III)], the substrate of the efflux system.	Arsenic	22-29	steroid sulfatase	Homo sapiens	49-53
8905098-11	1996	The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As (V)] to arsenite [As (III)], the substrate of the efflux system.	arsenic acid	101-109	steroid sulfatase	Homo sapiens	49-53
8905098-11	1996	The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As (V)] to arsenite [As (III)], the substrate of the efflux system.	asunaprevir	111-117	steroid sulfatase	Homo sapiens	49-53
8905098-11	1996	The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As (V)] to arsenite [As (III)], the substrate of the efflux system.	arsenite	122-130	steroid sulfatase	Homo sapiens	49-53
8905098-11	1996	The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As (V)] to arsenite [As (III)], the substrate of the efflux system.	as (iii)	132-140	steroid sulfatase	Homo sapiens	49-53
8691463-0	1996	Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates.	coumarin	69-77	steroid sulfatase	Homo sapiens	35-52
8900573-6	1995	Arsenate (AsV) is converted to arsenite by a soluble reductase (ArsC).	asunaprevir	10-13	steroid sulfatase	Homo sapiens	64-68
8900573-6	1995	Arsenate (AsV) is converted to arsenite by a soluble reductase (ArsC).	arsenite	31-39	steroid sulfatase	Homo sapiens	64-68
8070131-1	1994	Steroid sulfatase (STS) desulfates a number of 3 beta-hydroxysteroid sulfates, converting inactive steroid hormone to the active form.	beta-hydroxysteroid sulfates	49-77	steroid sulfatase	Homo sapiens	0-17
7629056-4	1995	The ArsC protein is an arsenate reductase that reduces arsenate to arsenite, which is subsequently pumped out of the cell.	arsenic acid	23-31	steroid sulfatase	Homo sapiens	4-8
7629056-4	1995	The ArsC protein is an arsenate reductase that reduces arsenate to arsenite, which is subsequently pumped out of the cell.	arsenite	67-75	steroid sulfatase	Homo sapiens	4-8
8777435-2	1995	UV susceptibility was appreciably reduced by the reactive oxygen species (ROS)-scavenger L-ascorbic acid-2-phosphate (Asc2P) endowed with long-lasting functions but not by L-ascorbic acid (Asc) for each cell type.	Reactive Oxygen Species	49-72	steroid sulfatase	Homo sapiens	118-121
8777435-2	1995	UV susceptibility was appreciably reduced by the reactive oxygen species (ROS)-scavenger L-ascorbic acid-2-phosphate (Asc2P) endowed with long-lasting functions but not by L-ascorbic acid (Asc) for each cell type.	Reactive Oxygen Species	74-77	steroid sulfatase	Homo sapiens	118-121
8777435-2	1995	UV susceptibility was appreciably reduced by the reactive oxygen species (ROS)-scavenger L-ascorbic acid-2-phosphate (Asc2P) endowed with long-lasting functions but not by L-ascorbic acid (Asc) for each cell type.	ascorbate-2-phosphate	89-116	steroid sulfatase	Homo sapiens	118-121
8777435-2	1995	UV susceptibility was appreciably reduced by the reactive oxygen species (ROS)-scavenger L-ascorbic acid-2-phosphate (Asc2P) endowed with long-lasting functions but not by L-ascorbic acid (Asc) for each cell type.	Ascorbic Acid	89-104	steroid sulfatase	Homo sapiens	118-121
8777435-5	1995	Thus, the three cell types differed in UV susceptibility partly because of their different ROS-scavenging abilities, which may be potently promoted by Asc2P or dehydroAsc but not Asc.	Reactive Oxygen Species	91-94	steroid sulfatase	Homo sapiens	151-154
8031713-2	1994	We tested these normal and transformed placental cells for expression of the enzyme sterylsulfatase which is necessary for the production of free steroids from sulfoconjugated precursors in the placenta as well as in other human tissues, and compared the results with respective data obtained from term placental tissue.	Steroids	146-154	steroid sulfatase	Homo sapiens	84-99
8039255-4	1994	Palmitate availability is calculated as C/p, when C is the concentration of bound palmitate.	Palmitates	0-9	steroid sulfatase	Homo sapiens	37-41
7696150-0	1995	Estrogenicity, antiestrogenicity and estrone sulfatase inhibition of estrone-3-amine and estrone-3-thiol.	3-Aminoestra-1,3,5(10)-trien-17-one	69-84	steroid sulfatase	Homo sapiens	37-54
7696150-0	1995	Estrogenicity, antiestrogenicity and estrone sulfatase inhibition of estrone-3-amine and estrone-3-thiol.	CHEMBL3971601	89-104	steroid sulfatase	Homo sapiens	37-54
7696150-2	1995	The high level of estrogen in these tumors is postulated to be due to in situ formation of estrogen, possibly through conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.	estrone sulfate	132-147	steroid sulfatase	Homo sapiens	173-190
7696150-2	1995	The high level of estrogen in these tumors is postulated to be due to in situ formation of estrogen, possibly through conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.	Estrone	132-139	steroid sulfatase	Homo sapiens	173-190
7792836-0	1995	Estrone sulfate analogs as estrone sulfatase inhibitors.	estrone sulfate	0-15	steroid sulfatase	Homo sapiens	27-44
8532709-10	1995	Like the phorbol esters, peroxides and hydroperoxides lead to a genetic reprogramming manifest by the induction of immediate early response genes such as c-jun and late response genes such as ornithine decarboxylase, suggesting convergence in the molecular signalling processes among different classes of promoters.	Phorbol Esters	9-23	steroid sulfatase	Homo sapiens	151-155
8532709-10	1995	Like the phorbol esters, peroxides and hydroperoxides lead to a genetic reprogramming manifest by the induction of immediate early response genes such as c-jun and late response genes such as ornithine decarboxylase, suggesting convergence in the molecular signalling processes among different classes of promoters.	Peroxides	25-34	steroid sulfatase	Homo sapiens	151-155
8532709-10	1995	Like the phorbol esters, peroxides and hydroperoxides lead to a genetic reprogramming manifest by the induction of immediate early response genes such as c-jun and late response genes such as ornithine decarboxylase, suggesting convergence in the molecular signalling processes among different classes of promoters.	Hydrogen Peroxide	39-53	steroid sulfatase	Homo sapiens	151-155
8070131-1	1994	Steroid sulfatase (STS) desulfates a number of 3 beta-hydroxysteroid sulfates, converting inactive steroid hormone to the active form.	Steroids	99-114	steroid sulfatase	Homo sapiens	0-17
8417823-0	1993	Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer.	estrone-3-methylthiophosphonate	44-75	steroid sulfatase	Homo sapiens	14-31
8180120-4	1994	Only vitamin D3 sulfate and 1 alpha 25-dihydroxyvitamin D inhibited the estrone sulfatase activity in human placental microsomes, albeit at high concentration (32 and 37% inhibition, respectively with 50 microns each inhibitor).	vitamin D3 sulfoconjugate	5-23	steroid sulfatase	Homo sapiens	72-89
8180120-4	1994	Only vitamin D3 sulfate and 1 alpha 25-dihydroxyvitamin D inhibited the estrone sulfatase activity in human placental microsomes, albeit at high concentration (32 and 37% inhibition, respectively with 50 microns each inhibitor).	1,25-dihydroxyvitamin D	28-57	steroid sulfatase	Homo sapiens	72-89
8664167-1	1993	Steroid sulfatase (STS) is a single enzyme with a range of substrate specificities, including estrone sulfate.	estrone sulfate	94-109	steroid sulfatase	Homo sapiens	0-17
8664170-1	1993	Estrone sulfatase is an important enzyme which catalyzes the production of estrone from estrone sulfate in a variety of human and animal tissues.	Estrone	75-82	steroid sulfatase	Homo sapiens	0-17
8664170-1	1993	Estrone sulfatase is an important enzyme which catalyzes the production of estrone from estrone sulfate in a variety of human and animal tissues.	estrone sulfate	88-103	steroid sulfatase	Homo sapiens	0-17
8417823-1	1993	Many breast tumors are hormone dependent, and there is evidence that hydrolysis of estrone sulfate (E1S) to estrone, by estrone sulfatase, is an important source of the estrogen which is found in tumors.	estrone sulfate	83-98	steroid sulfatase	Homo sapiens	120-137
8417823-2	1993	In this study, we have developed a novel pathway for the synthesis of estrone-3-methylthiophosphonate (E1-3-MTP) and examined its ability to inhibit estrone sulfatase activity in MCF-7 breast cancer cells and human placental and breast tumor preparations.	estrone-3-methylthiophosphonate	70-101	steroid sulfatase	Homo sapiens	149-166
8417823-2	1993	In this study, we have developed a novel pathway for the synthesis of estrone-3-methylthiophosphonate (E1-3-MTP) and examined its ability to inhibit estrone sulfatase activity in MCF-7 breast cancer cells and human placental and breast tumor preparations.	estrone-3-methylthiophosphonate	103-111	steroid sulfatase	Homo sapiens	149-166
1873987-11	1991	The human hepatic ASC was separable from SS by electrophoresis and was partially resolved from SS by DEAE-Sephacel chromatography.	2-diethylaminoethanol	101-105	steroid sulfatase	Homo sapiens	18-21
8487498-8	1993	Residual activity of steroid sulphatase was also not found after prolonged incubation of this fibroblast extract with the natural substrate oestrone sulphate.	estrone sulfate	140-157	steroid sulfatase	Homo sapiens	21-39
1446715-1	1992	Immediate-early genes such as c-fos and NGFI-A are rapidly and transiently expressed in the striatum following amphetamine administration in vivo.	Amphetamine	111-122	steroid sulfatase	Homo sapiens	27-31
1580921-10	1992	The estrone sulfatase activity can be inhibited by progesterone, the progestagen R-5020, and testosterone.	Progesterone	51-63	steroid sulfatase	Homo sapiens	4-21
1751397-6	1991	A comparison was made between the effects of demegestone, medroxyprogesterone acetate and danazol on estrone sulfatase activity measured with or without Triton X-100 in the incubation medium.	Medroxyprogesterone Acetate	58-85	steroid sulfatase	Homo sapiens	101-118
1751397-6	1991	A comparison was made between the effects of demegestone, medroxyprogesterone acetate and danazol on estrone sulfatase activity measured with or without Triton X-100 in the incubation medium.	Danazol	90-97	steroid sulfatase	Homo sapiens	101-118
1751397-10	1991	Progestogens such as demegestone and chlormadinone acetate which inhibited estrone sulfatase activity in intact preparations, can reduce the intracellular production of biological active estrogen via the sulfatase pathway.	demegestone	21-32	steroid sulfatase	Homo sapiens	75-92
1751397-10	1991	Progestogens such as demegestone and chlormadinone acetate which inhibited estrone sulfatase activity in intact preparations, can reduce the intracellular production of biological active estrogen via the sulfatase pathway.	Chlormadinone Acetate	37-58	steroid sulfatase	Homo sapiens	75-92
1911438-4	1991	Danazol produced a significant inhibition of estrone sulfatase (20% with 50 microM danazol).	Danazol	0-7	steroid sulfatase	Homo sapiens	45-62
1911438-4	1991	Danazol produced a significant inhibition of estrone sulfatase (20% with 50 microM danazol).	Danazol	83-90	steroid sulfatase	Homo sapiens	45-62
2212823-10	1990	These results suggest that estrone sulfate is hydrolyzed mainly by estrone sulfatase in the endometrium and myometrium surrounding leiomyoma nodes and the estrone formed may affect the growth of leiomyoma.	estrone sulfate	27-42	steroid sulfatase	Homo sapiens	67-84
2212823-10	1990	These results suggest that estrone sulfate is hydrolyzed mainly by estrone sulfatase in the endometrium and myometrium surrounding leiomyoma nodes and the estrone formed may affect the growth of leiomyoma.	Estrone	27-34	steroid sulfatase	Homo sapiens	67-84
2347893-1	1990	Steroid sulfatase (STS), an important enzyme in the pathway of estrogen synthesis from sulfated steroid precursors, was localized to the syncytial trophoblast of human placentas during different periods of pregnancy by using a mouse monoclonal antibody and immunocytochemical techniques.	Steroids	96-103	steroid sulfatase	Homo sapiens	0-17
34785054-3	2022	Here, binary heterogeneous nanocomplexes constructed from silver nanoparticles and carbon nanomaterials (termed as C-Ag NPs) were reported.	Silver	58-64	steroid sulfatase	Homo sapiens	112-116
2101801-2	1990	Placental ASC hydrolyzed sterol sulfates at the same active site, whereas the major hepatic ASC did not.	sterol sulfates	25-40	steroid sulfatase	Homo sapiens	10-13
34785054-3	2022	Here, binary heterogeneous nanocomplexes constructed from silver nanoparticles and carbon nanomaterials (termed as C-Ag NPs) were reported.	Carbon	83-89	steroid sulfatase	Homo sapiens	112-116
34737124-5	2022	Tetracycline also increased the abundances of As-reducing genes (arsC and arrA) and the relative abundances of As-reducing bacteria Streptomyces, Bacillus, Burkholderia, Clostridium and Rhodococcus, all of which have been found resistant to tetracycline.	Tetracycline	0-12	steroid sulfatase	Homo sapiens	65-69
33322953-0	2021	New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives.	6-(1-phenyl-1h-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate	50-110	steroid sulfatase	Homo sapiens	11-29
33322953-1	2021	In the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives.	6-(1-phenyl-1h-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate	98-158	steroid sulfatase	Homo sapiens	53-71
33765496-2	2021	It was later discovered that by cleavage of the sulfate residue by steroid sulfatase (STS), they can be (re-)converted into active forms or into precursors for the local production of active steroids.	Sulfates	48-55	steroid sulfatase	Homo sapiens	67-84
33765496-2	2021	It was later discovered that by cleavage of the sulfate residue by steroid sulfatase (STS), they can be (re-)converted into active forms or into precursors for the local production of active steroids.	Steroids	191-199	steroid sulfatase	Homo sapiens	67-84
34742179-4	2021	Furthermore, GBs easily form vacancies with deep defect electronic states and are also preferential segregation sites for various impurity species, such as C, N, and O.	gbs	13-16	steroid sulfatase	Homo sapiens	153-157
34688910-5	2021	Twelve congeners of PCB sulfates were substrates for the microsomal sulfatase with catalytic rates exceeding that of dehydroepiandrosterone sulfate as a comparison substrate for steroid sulfatase (STS).	Dehydroepiandrosterone Sulfate	117-147	steroid sulfatase	Homo sapiens	178-195
34500864-1	2021	Additions of andalusite aggregates (19 wt%) were shown in previous literature to enhance the antioxidation of Al2O3-SiC-C (ASC) castables.	andalusite	13-23	steroid sulfatase	Homo sapiens	110-121
34675221-1	2021	Human steroid sulfatase (STS) is an enzyme that catalyzes the hydrolysis of dehydroepiandrosterone sulfate (DHEAS), estrone sulfate (E1S), and cholesterol sulfate.	Dehydroepiandrosterone Sulfate	76-106	steroid sulfatase	Homo sapiens	6-23
34675221-1	2021	Human steroid sulfatase (STS) is an enzyme that catalyzes the hydrolysis of dehydroepiandrosterone sulfate (DHEAS), estrone sulfate (E1S), and cholesterol sulfate.	Dehydroepiandrosterone Sulfate	108-113	steroid sulfatase	Homo sapiens	6-23
34675221-1	2021	Human steroid sulfatase (STS) is an enzyme that catalyzes the hydrolysis of dehydroepiandrosterone sulfate (DHEAS), estrone sulfate (E1S), and cholesterol sulfate.	estrone sulfate	116-131	steroid sulfatase	Homo sapiens	6-23
34675221-1	2021	Human steroid sulfatase (STS) is an enzyme that catalyzes the hydrolysis of dehydroepiandrosterone sulfate (DHEAS), estrone sulfate (E1S), and cholesterol sulfate.	N~2~-{3-[4-(5-Methylthiophen-2-Yl)phenyl]propanoyl}-L-Alpha-Glutamine	133-136	steroid sulfatase	Homo sapiens	6-23
34675221-1	2021	Human steroid sulfatase (STS) is an enzyme that catalyzes the hydrolysis of dehydroepiandrosterone sulfate (DHEAS), estrone sulfate (E1S), and cholesterol sulfate.	cholesteryl sulfate	143-162	steroid sulfatase	Homo sapiens	6-23
34554397-8	2022	By studying 22 MLD patients, 18 different variations of the ARSA gene were found, one of which was new including, named as c.472 T > G p. (Cys158Gly).	cys158gly	139-148	steroid sulfatase	Homo sapiens	120-124
34500864-1	2021	Additions of andalusite aggregates (19 wt%) were shown in previous literature to enhance the antioxidation of Al2O3-SiC-C (ASC) castables.	andalusite	13-23	steroid sulfatase	Homo sapiens	123-126
34500864-3	2021	Various low contents (5 wt% and below) of micronized andalusite (<=5 mum) were introduced as a substitute for brown fused alumina in the matrix of ASC castables.	Aluminum Oxide	122-129	steroid sulfatase	Homo sapiens	147-150
2796962-4	1989	Aromatase activity was measured by 3H2O release assay using (1 beta-3H) androstenedione as the substrate, while estrone sulfatase activity was estimated from the conversion rate of (6,7-3H)estrone-3-sulfate to estrone.	(6,7-3h)estrone-3-sulfate	181-206	steroid sulfatase	Homo sapiens	112-129
34395085-5	2021	Characteristic patterns of ancient DNA damage, namely DNA fragmentation and cytosine deamination (observed as C-to-T transitions) are typically used to authenticate ancient samples and sequences, but existing tools for inspecting and filtering aDNA damage either compute it at the read level, which leads to high data loss and lower quality when used in combination with de novo assembly, or require manual inspection, which is impractical for ancient assemblies that typically contain tens to hundreds of thousands of contigs.	Cytosine	76-84	steroid sulfatase	Homo sapiens	107-111
34064842-1	2021	Steroid sulphatase (STS), involved in the hydrolysis of steroid sulphates, plays an important role in the formation of both active oestrogens and androgens.	Steroids	56-63	steroid sulfatase	Homo sapiens	0-18
2610928-9	1989	This localisation of sterylsulfatase may have functional implications in the placental uptake of circulating steroid sulfates.	steroid sulfates	109-125	steroid sulfatase	Homo sapiens	21-36
34235920-1	2021	The carbon-coated LiMn0.5Fe0.5PO4@Li0.33La0.56TiO3 nanorod composites (denoted as C/LMFP@LLTO) have been successfully obtained according to a common hydrothermal synthesis following a post-calcination treatment.	Carbon	4-10	steroid sulfatase	Homo sapiens	79-83
35235747-0	2022	Development of Sulfamoylated 4-(1-Phenyl-1H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer.	4-(1-phenyl-1h-1,2,3-triazol-4-yl)phenol	29-69	steroid sulfatase	Homo sapiens	92-109
35235747-1	2022	We present here the advances achieved in the development of new sulfamoylated 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives as potent steroid sulfatase (STS) inhibitors for the treatment of breast cancer.	4-(1-phenyl-1h-1,2,3-triazol-4-yl)phenol	78-118	steroid sulfatase	Homo sapiens	141-158
3471087-1	1987	Steroid sulfatase (STS; E.C.3.1.6.2), which acts on 3-hydroxysteroid sulfates, and arylsulfatase-C (ARC; E.C.3.1.6.1), assayed with aromatic artificial substrates, are both membrane-bound, microsomal enzymes with alkaline pH optima.	3-hydroxysteroid sulfates	52-77	steroid sulfatase	Homo sapiens	0-17
2884621-1	1987	Deficiency of steroid sulphatase (STS) is associated with ichthyosis, with failure of the placental production of oestriol in late pregnancy and with difficulties in childbirth.	Estriol	114-122	steroid sulfatase	Homo sapiens	14-32
2533306-1	1989	Arylsulphatase C (ASC) activity in leukocytes and fibroblasts measured with 4-methylumbelliferylsulphate, is caused by at least two genetically different sulphatases.	4-methylumbelliferylsulphate	76-104	steroid sulfatase	Homo sapiens	0-16
2533306-1	1989	Arylsulphatase C (ASC) activity in leukocytes and fibroblasts measured with 4-methylumbelliferylsulphate, is caused by at least two genetically different sulphatases.	4-methylumbelliferylsulphate	76-104	steroid sulfatase	Homo sapiens	18-21
2533306-4	1989	Steroid sulphatase can be measured specifically with 4-methylumbelliferylsulphate as the fraction of total ASC activity which is inhibitable by dehydroepiandrosterone sulphate.	4-methylumbelliferylsulphate	53-81	steroid sulfatase	Homo sapiens	0-18
2533306-4	1989	Steroid sulphatase can be measured specifically with 4-methylumbelliferylsulphate as the fraction of total ASC activity which is inhibitable by dehydroepiandrosterone sulphate.	4-methylumbelliferylsulphate	53-81	steroid sulfatase	Homo sapiens	107-110
2533306-4	1989	Steroid sulphatase can be measured specifically with 4-methylumbelliferylsulphate as the fraction of total ASC activity which is inhibitable by dehydroepiandrosterone sulphate.	Dehydroepiandrosterone Sulfate	144-175	steroid sulfatase	Homo sapiens	0-18
2533306-4	1989	Steroid sulphatase can be measured specifically with 4-methylumbelliferylsulphate as the fraction of total ASC activity which is inhibitable by dehydroepiandrosterone sulphate.	Dehydroepiandrosterone Sulfate	144-175	steroid sulfatase	Homo sapiens	107-110
3480692-5	1987	This band contained most of the estrone sulfatase (estrone sulfate to estrone) activity.	estrone sulfate	51-66	steroid sulfatase	Homo sapiens	32-49
3480692-14	1987	Partial separation of estrone sulfatase from 3 beta-hydroxysteroid dehydrogenase and prostaglandin F2 alpha metabolizing activities has been demonstrated, which raises the possibility of paracrine interactions in vivo.	Dinoprost	85-101	steroid sulfatase	Homo sapiens	22-39
3316977-4	1987	Treatment of HeLa cells with arsenite or heavy metals also resulted in increased levels of hsp 70, as well as c-fos mRNA.	arsenite	29-37	steroid sulfatase	Homo sapiens	107-111
2448986-3	1987	In human hair follicles, however, hydrolytic activity for 4-methylumbelliferone sulfate, the substrate for arylsulfatase C, is found, while dehydroepiandrosterone sulfate is not hydrolyzed at all.	4-methylumbelliferyl sulfate	58-87	steroid sulfatase	Homo sapiens	107-122
3106720-1	1987	In Triton X-100 solubilized leukocytes of 17 patients and 8 obligate carriers of X-linked recessive ichthyosis (XLI) the activity of arylsulphatase C (ASC) was determined and expressed as the ratio to beta-galactosidase activity.	Octoxynol	3-15	steroid sulfatase	Homo sapiens	133-149
3106720-4	1987	These results indicate that the determination of the enzyme ratio of ASC/beta-gal in Triton X-100 solubilized leukocytes is a sensitive test for biochemical identification of patients and probably of carriers of XLI.	beta-D-galactose	73-81	steroid sulfatase	Homo sapiens	69-72
3106720-4	1987	These results indicate that the determination of the enzyme ratio of ASC/beta-gal in Triton X-100 solubilized leukocytes is a sensitive test for biochemical identification of patients and probably of carriers of XLI.	Octoxynol	85-97	steroid sulfatase	Homo sapiens	69-72
3464600-1	1986	When arylsulfatase C, a microsomal membrane-bound enzyme, is assayed with its natural substrates, the 3-beta-hydroxysteroid sulfates, it is also known as steroid sulfatase.	3-beta-hydroxysteroid sulfates	102-132	steroid sulfatase	Homo sapiens	5-20
2424236-1	1986	Steroid sulphatase (STS) activity was measured with tritiated dehydroepiandrosterone sulphate (DHEAS) and oestrone sulphate (OES) in leucocytes as well as in skin fibroblasts from 31 women who were presumed to be carriers of STS deficiency and recessive X-linked ichthyosis.	Dehydroepiandrosterone Sulfate	62-93	steroid sulfatase	Homo sapiens	0-18
3083810-1	1986	Pulse labeling followed by SDS-PAGE electrophoresis of immunoprecipitated [35S]methionine-labeled steroid sulfatase (STS) gave a single band of molecular weight 65,000 daltons.	Sodium Dodecyl Sulfate	27-30	steroid sulfatase	Homo sapiens	98-115
3083810-1	1986	Pulse labeling followed by SDS-PAGE electrophoresis of immunoprecipitated [35S]methionine-labeled steroid sulfatase (STS) gave a single band of molecular weight 65,000 daltons.	Sulfur-35	75-78	steroid sulfatase	Homo sapiens	98-115
3083810-1	1986	Pulse labeling followed by SDS-PAGE electrophoresis of immunoprecipitated [35S]methionine-labeled steroid sulfatase (STS) gave a single band of molecular weight 65,000 daltons.	Methionine	79-89	steroid sulfatase	Homo sapiens	98-115
2424236-1	1986	Steroid sulphatase (STS) activity was measured with tritiated dehydroepiandrosterone sulphate (DHEAS) and oestrone sulphate (OES) in leucocytes as well as in skin fibroblasts from 31 women who were presumed to be carriers of STS deficiency and recessive X-linked ichthyosis.	estrone sulfate	106-123	steroid sulfatase	Homo sapiens	0-18
2424236-1	1986	Steroid sulphatase (STS) activity was measured with tritiated dehydroepiandrosterone sulphate (DHEAS) and oestrone sulphate (OES) in leucocytes as well as in skin fibroblasts from 31 women who were presumed to be carriers of STS deficiency and recessive X-linked ichthyosis.	estrone sulfate	125-128	steroid sulfatase	Homo sapiens	0-18
6581863-6	1984	Estrone sulfate, the substrate of estrone sulfatase, has been measured in plasma of postmenopausal women.	estrone sulfate	0-15	steroid sulfatase	Homo sapiens	34-51
3857872-7	1985	With Triton X-100 and Miranol representing the two groups of detergents, significant release occurred only when the detergent concentrations exceeded their respective critical micelle concentrations, thus indicating that arylsulfatase-C is an integral membrane protein.	Octoxynol	5-17	steroid sulfatase	Homo sapiens	221-236
3857872-7	1985	With Triton X-100 and Miranol representing the two groups of detergents, significant release occurred only when the detergent concentrations exceeded their respective critical micelle concentrations, thus indicating that arylsulfatase-C is an integral membrane protein.	Sodium Fluoride	22-29	steroid sulfatase	Homo sapiens	221-236
3857872-10	1985	Therefore, the amphoteric detergent, Miranol, appears to fulfill the requirements for further characterization of the membrane-bound arylsulfatase-C in human cultured fibroblasts.	Sodium Fluoride	37-44	steroid sulfatase	Homo sapiens	133-148
6582028-1	1984	Steroid sulphatase (STS) activity was measured with two different steroid substrates in leucocytes from normal human males and females, from females heterozygous for STS deficiency and recessive X-linked ichthyosis, and from individuals with numerical X chromosome aberrations.	Steroids	66-73	steroid sulfatase	Homo sapiens	0-18
33945801-1	2021	17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) and steroid sulfatase (STS) are involved in the synthesis of the most potent estrogen in the human body, estradiol (E2).	Estradiol	173-175	steroid sulfatase	Homo sapiens	61-78
6957717-2	1982	The X-locus for steroid sulphatase (STS; EC 3.1.6.2), the microsomal enzyme that catalyses the hydrolysis of various 3 beta-hydroxysteroid sulphates, is exceptional because it seems to escape inactivation.	beta-hydroxysteroid sulphates	119-148	steroid sulfatase	Homo sapiens	16-34
437987-0	1979	Epoxytrichothecene mycotoxins as c-mitotic agents in Allium.	epoxytrichothecene mycotoxins	0-29	steroid sulfatase	Homo sapiens	30-34
34030306-6	2021	Microcosm experiments confirmed that with the increase of the As(III) content (0% to 50%, of 200 mg/kg total arsenic) in the soil, inoculation of lysogenic phages with both arsC and arsM resulted in more transduction of arsM (0.06 +- 0.007 to 0.23 +- 0.024 per 16S rRNA) among soil microorganisms.	arsm	220-224	steroid sulfatase	Homo sapiens	173-177
33945801-0	2021	Synthesis of 16beta-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17beta-ol as inhibitors of 17beta-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseases.	16beta	13-19	steroid sulfatase	Homo sapiens	120-137
6930360-1	1980	Steroid sulfatase (STS) activities in female fibroblast strains are significantly higher than in male strains, as determined by cleavage of dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	140-170	steroid sulfatase	Homo sapiens	0-17
33783002-1	2021	Imatinib (IM) is a pharmaceutical drug that inhibits tyrosine kinase enzymes that are responsible for the activation of many proteins by signal transduction cascades as c-Abl, c-Kit and the platelet-derived growth factor (PDGF) receptor.	Imatinib Mesylate	0-8	steroid sulfatase	Homo sapiens	166-170
33783002-1	2021	Imatinib (IM) is a pharmaceutical drug that inhibits tyrosine kinase enzymes that are responsible for the activation of many proteins by signal transduction cascades as c-Abl, c-Kit and the platelet-derived growth factor (PDGF) receptor.	Imatinib Mesylate	10-12	steroid sulfatase	Homo sapiens	166-170
33783295-1	2021	INTRODUCTION: Steroid sulfatase (STS) enzyme is responsible for transforming the inactive sulfate metabolites of steroid sex hormones into the active free steroids.	Sulfates	90-97	steroid sulfatase	Homo sapiens	14-31
33783295-1	2021	INTRODUCTION: Steroid sulfatase (STS) enzyme is responsible for transforming the inactive sulfate metabolites of steroid sex hormones into the active free steroids.	Steroids	113-120	steroid sulfatase	Homo sapiens	14-31
33783295-1	2021	INTRODUCTION: Steroid sulfatase (STS) enzyme is responsible for transforming the inactive sulfate metabolites of steroid sex hormones into the active free steroids.	Steroids	155-163	steroid sulfatase	Homo sapiens	14-31
34028269-2	2021	We present a low-temperature scanning tunneling microscopy and spectroscopy (LT-STM/STS) study of a two-dimensional (2D) monolayer CTC of tetrathiafulvalene (TTF) and fluorinated tetracyanoquinodimethane (F4TCNQ), self-assembled on the surface of oxygen-intercalated epitaxial graphene on Ir(111) (G/O/Ir(111)).	tetrathiafulvalene	138-156	steroid sulfatase	Homo sapiens	77-87
34028269-2	2021	We present a low-temperature scanning tunneling microscopy and spectroscopy (LT-STM/STS) study of a two-dimensional (2D) monolayer CTC of tetrathiafulvalene (TTF) and fluorinated tetracyanoquinodimethane (F4TCNQ), self-assembled on the surface of oxygen-intercalated epitaxial graphene on Ir(111) (G/O/Ir(111)).	tetrathiafulvalene	158-161	steroid sulfatase	Homo sapiens	77-87
33945801-0	2021	Synthesis of 16beta-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17beta-ol as inhibitors of 17beta-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseases.	3-(2-bromoethyl)-estra-1,3,5(10)-trien-17beta-ol	35-83	steroid sulfatase	Homo sapiens	120-137
33945801-1	2021	17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) and steroid sulfatase (STS) are involved in the synthesis of the most potent estrogen in the human body, estradiol (E2).	Estradiol	162-171	steroid sulfatase	Homo sapiens	61-78
33865142-3	2021	The bacterium has both the arsC gene for intracellular arsenate reduction and an EET pathway for transferring electrons to an electrode or Fe(III).	arsenic acid	55-63	steroid sulfatase	Homo sapiens	27-31
33314517-2	2021	After treating at high temperature, the organosiloxane changed to form a cross-linked polysiloxane (called as c-FSi-BCB).	organosiloxane	40-54	steroid sulfatase	Homo sapiens	107-111
32705921-0	2021	Lead optimization of 4-(thio)-chromenone 6-O-sulfamate analogs using QSAR, molecular docking and DFT - a combined approach as steroidal sulfatase inhibitors.	4-(thio)-chromenone 6-o-sulfamate	21-54	steroid sulfatase	Homo sapiens	126-145
33314517-2	2021	After treating at high temperature, the organosiloxane changed to form a cross-linked polysiloxane (called as c-FSi-BCB).	Siloxanes	86-98	steroid sulfatase	Homo sapiens	107-111
32120093-2	2020	Two arsenate reducing genes, arsC and arrA, were both amplified in an indigenous bacterium Bacillus XZM isolated from high arsenic aquifer sediments.	arsenic acid	4-12	steroid sulfatase	Homo sapiens	29-33
32930176-1	2020	In this paper, a novel high flexibility all-solid contact ion selective electrode (ASC-ISE) based on reduced graphene sheets (RGSs) as the ion-to-electron transducer was developed for rapid detection of sulfide.	Graphite	109-117	steroid sulfatase	Homo sapiens	83-86
32930176-1	2020	In this paper, a novel high flexibility all-solid contact ion selective electrode (ASC-ISE) based on reduced graphene sheets (RGSs) as the ion-to-electron transducer was developed for rapid detection of sulfide.	Sulfides	203-210	steroid sulfatase	Homo sapiens	83-86
32930176-4	2020	The evaluation of the analytical performances, such as the linear range, selectivity, stability, and practical application, of the proposed ASC-ISEs for the rapid detection of sulfide was performed.	Sulfides	176-183	steroid sulfatase	Homo sapiens	140-143
32930176-5	2020	The results showed that, the ASC-ISEs exhibited a linear relationship between the obtained potential signal and sulfide concentration in the range of 0.50 muM to 1.0 mM, with a detection limit of 0.18 muM.	Sulfides	112-119	steroid sulfatase	Homo sapiens	29-32
32930176-6	2020	Moreover, the ASC-ISEs showed good selectivity towards sulfide over other common interfering ions, and maintained a stable electrochemical response over 7 days.	Sulfides	55-62	steroid sulfatase	Homo sapiens	14-17
32930176-7	2020	These results demonstrated that graphene was a promising material as the ion-to-electron transducer layer in the development of ASC-ISEs for sulfide detection, and the results of practical applications in tap water and seawater samples showed that the ASC-ISEs held significant promise in a broad range of applications.	Graphite	32-40	steroid sulfatase	Homo sapiens	128-131
32930176-7	2020	These results demonstrated that graphene was a promising material as the ion-to-electron transducer layer in the development of ASC-ISEs for sulfide detection, and the results of practical applications in tap water and seawater samples showed that the ASC-ISEs held significant promise in a broad range of applications.	Graphite	32-40	steroid sulfatase	Homo sapiens	252-255
32930176-7	2020	These results demonstrated that graphene was a promising material as the ion-to-electron transducer layer in the development of ASC-ISEs for sulfide detection, and the results of practical applications in tap water and seawater samples showed that the ASC-ISEs held significant promise in a broad range of applications.	Sulfides	141-148	steroid sulfatase	Homo sapiens	128-131
32930176-7	2020	These results demonstrated that graphene was a promising material as the ion-to-electron transducer layer in the development of ASC-ISEs for sulfide detection, and the results of practical applications in tap water and seawater samples showed that the ASC-ISEs held significant promise in a broad range of applications.	Sulfides	141-148	steroid sulfatase	Homo sapiens	252-255
32930176-7	2020	These results demonstrated that graphene was a promising material as the ion-to-electron transducer layer in the development of ASC-ISEs for sulfide detection, and the results of practical applications in tap water and seawater samples showed that the ASC-ISEs held significant promise in a broad range of applications.	Water	209-214	steroid sulfatase	Homo sapiens	252-255
33238540-4	2020	In this study we show that the proto-oncogene tyrosine-protein kinase Src, also known as c-src, plays a crucial role in the anticancer effect of EGCG.	epigallocatechin gallate	145-149	steroid sulfatase	Homo sapiens	86-90
33196984-8	2021	Based on the arsC gene analysis, the indigenous arsenate-reducing bacterial communities were mainly affiliated with Omnitrophica (88%) and Deltaproteobacteria (11%, dominated by Geobacter and Syntrophobacterales).	arsenic acid	48-56	steroid sulfatase	Homo sapiens	13-17
32928794-3	2020	The conversion of DHEAS into DHEA by steroid sulfatase (STS) may contribute to sustained intracrine androgen synthesis.	Dehydroepiandrosterone Sulfate	18-23	steroid sulfatase	Homo sapiens	37-54
32928794-3	2020	The conversion of DHEAS into DHEA by steroid sulfatase (STS) may contribute to sustained intracrine androgen synthesis.	Dehydroepiandrosterone	18-22	steroid sulfatase	Homo sapiens	37-54
31773975-1	2020	A series of fluorinated analogs based on the frameworks of 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamates have been synthesized as steroid sulfatase (STS) inhibitors.	4-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate	59-112	steroid sulfatase	Homo sapiens	138-155
32120093-2	2020	Two arsenate reducing genes, arsC and arrA, were both amplified in an indigenous bacterium Bacillus XZM isolated from high arsenic aquifer sediments.	Arsenic	123-130	steroid sulfatase	Homo sapiens	29-33
32120093-6	2020	The data of real-time quantitative PCR (qPCR) indicated arsenate was involved in the expressions of two arsenate reductase genes (arsC and arrA genes) in indigenous bacterium Bacillus XZM.	arsenic acid	56-64	steroid sulfatase	Homo sapiens	130-134
32435230-3	2020	Approximately 74% of DHEAS is hydrolyzed to DHEA by the steroid sulfatase (STS).	Dehydroepiandrosterone Sulfate	21-26	steroid sulfatase	Homo sapiens	56-73
32435230-3	2020	Approximately 74% of DHEAS is hydrolyzed to DHEA by the steroid sulfatase (STS).	Dehydroepiandrosterone	21-25	steroid sulfatase	Homo sapiens	56-73
32059152-0	2020	Design and synthesis of 3-benzylaminocoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors.	3-benzylaminocoumarin-7-o-sulfamate	24-59	steroid sulfatase	Homo sapiens	75-92
32200199-0	2020	Structure-based discovery of novel 4-(2-fluorophenoxy)quinoline derivatives as c-Met inhibitors using isocyanide-involved multicomponent reactions.	4-(2-fluorophenoxy)quinoline	35-63	steroid sulfatase	Homo sapiens	76-80
32200199-0	2020	Structure-based discovery of novel 4-(2-fluorophenoxy)quinoline derivatives as c-Met inhibitors using isocyanide-involved multicomponent reactions.	Cyanides	102-112	steroid sulfatase	Homo sapiens	76-80
32122754-1	2020	Steroid sulfatase (STS) is an important enzyme regulating the conversion of sulfated steroids into their active hydroxylated forms.	Steroids	85-93	steroid sulfatase	Homo sapiens	0-17
32843861-8	2020	ASCUS was present in 4.9% (N-544), LSIL in 3.04% (N-337), HSIL in 0.74% (N-84), ASC-H in 0.27% (N-30) and AGC in 0.49% (N-55) of cases.	agc	106-109	steroid sulfatase	Homo sapiens	0-3
32059152-1	2020	Steroid sulfatase (STS) is a sulfatase enzyme that catalyzes the conversion of sulfated steroid precursors to free steroid.	Steroids	88-95	steroid sulfatase	Homo sapiens	0-17
32059152-1	2020	Steroid sulfatase (STS) is a sulfatase enzyme that catalyzes the conversion of sulfated steroid precursors to free steroid.	Steroids	115-122	steroid sulfatase	Homo sapiens	0-17
31422224-0	2019	Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors.	piperazinyl-ureido sulfamates	37-66	steroid sulfatase	Homo sapiens	70-87
31957981-2	2020	Yet, the energy density of ASC is severely limited by the low capacitance of the anode side, which commonly uses the carbon-based nanomaterials.	Carbon	117-123	steroid sulfatase	Homo sapiens	27-30
31957981-3	2020	Here, the demonstration of sulfur-doped MoO3- x nanobelts (denoted as S-MoO3- x ) as the anode for high-performance fiber-shaped ASC are reported.	Sulfur	27-33	steroid sulfatase	Homo sapiens	129-132
31957981-3	2020	Here, the demonstration of sulfur-doped MoO3- x nanobelts (denoted as S-MoO3- x ) as the anode for high-performance fiber-shaped ASC are reported.	molybdenum trioxide	40-44	steroid sulfatase	Homo sapiens	129-132
31957981-3	2020	Here, the demonstration of sulfur-doped MoO3- x nanobelts (denoted as S-MoO3- x ) as the anode for high-performance fiber-shaped ASC are reported.	molybdenum disulfide	70-79	steroid sulfatase	Homo sapiens	129-132
31957981-7	2020	More impressively, the fiber-shaped ASC based on S-MoO3- x anode delivers extremely high volumetric capacitance of 6.19 F cm-3 at 0.5 mA cm-1 , which makes it promising as one of the most attractive candidates of anode materials for high-performance fiber-shaped ASCs.	molybdenum disulfide	49-55	steroid sulfatase	Homo sapiens	36-39
31904042-1	2020	Herein, a novel two-photon ratiometric fluorescence assay was proposed for monitoring endogenous steroid sulfatase (STS) activity, which could be applied for the ratiometric imaging of STS activity in the endoplasmic reticulum of living cells and tissues and also could be used to distinguish estrogen-dependent tumor cells from other types of cells.	Estrogens	293-301	steroid sulfatase	Homo sapiens	97-114
31422224-1	2019	Two new piperazinyl-ureido single ring aryl sulfamate-based inhibitor series were designed against the emerging oncology drug target steroid sulfatase (STS), for which there are existing potent steroidal and non-steroidal agents in clinical trials.	piperazinyl-ureido	8-26	steroid sulfatase	Homo sapiens	133-150
31422224-1	2019	Two new piperazinyl-ureido single ring aryl sulfamate-based inhibitor series were designed against the emerging oncology drug target steroid sulfatase (STS), for which there are existing potent steroidal and non-steroidal agents in clinical trials.	aryl sulfamate	39-53	steroid sulfatase	Homo sapiens	133-150
31301181-0	2019	Novel steroid sulfatase inhibitors based on N-thiophosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates.	3-(4-aminophenyl)-coumarin-7-o-sulfamates	65-106	steroid sulfatase	Homo sapiens	6-23
31414521-0	2019	Design, synthesis and biological evaluation of 6-substituted quinolines derived from cabozantinib as c-Met inhibitors.	6-substituted quinolines	47-71	steroid sulfatase	Homo sapiens	98-102
31414521-0	2019	Design, synthesis and biological evaluation of 6-substituted quinolines derived from cabozantinib as c-Met inhibitors.	cabozantinib	85-97	steroid sulfatase	Homo sapiens	98-102
31301181-1	2019	In the present work, we described convenient methods for the synthesis of N-thiophosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates as steroid sulfatase (STS) inhibitors.	Nitrogen	74-75	steroid sulfatase	Homo sapiens	140-157
31301181-1	2019	In the present work, we described convenient methods for the synthesis of N-thiophosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates as steroid sulfatase (STS) inhibitors.	3-(4-aminophenyl)-coumarin-7-o	95-125	steroid sulfatase	Homo sapiens	140-157
30986666-6	2019	Results showed that the consortia PsGo and StSp were able to decolorize 54 and 34 percent of RB-5 (50 mg/L) during 7 days.	rb-5	93-97	steroid sulfatase	Homo sapiens	43-47
31481945-4	2019	We found that arsC and ereA genes coding for resistance mechanisms to arsenic and to macrolides, respectively, are the most abundant MRG and ARG in the study area.	Arsenic	70-77	steroid sulfatase	Homo sapiens	14-18
31481945-4	2019	We found that arsC and ereA genes coding for resistance mechanisms to arsenic and to macrolides, respectively, are the most abundant MRG and ARG in the study area.	Macrolides	85-95	steroid sulfatase	Homo sapiens	14-18
31481945-4	2019	We found that arsC and ereA genes coding for resistance mechanisms to arsenic and to macrolides, respectively, are the most abundant MRG and ARG in the study area.	mrg	133-136	steroid sulfatase	Homo sapiens	14-18
31481945-4	2019	We found that arsC and ereA genes coding for resistance mechanisms to arsenic and to macrolides, respectively, are the most abundant MRG and ARG in the study area.	Arginine	141-144	steroid sulfatase	Homo sapiens	14-18
30986666-8	2019	Over longer periods, StSp consortium managed to completely decolorize RB-5 (50 mg/L) at optimized conditions of 25-30  C, pH 9, and using glucose and NH4H2PO4 as carbon and nitrogen source respectively, whereas PsGo consortium decolorized RB-5 (50 mg/mL) completely at 37  C, pH 11, and with lactose and NH4H2PO4 used as carbon and nitrogen sources.	rb-5	70-74	steroid sulfatase	Homo sapiens	21-25
30986666-8	2019	Over longer periods, StSp consortium managed to completely decolorize RB-5 (50 mg/L) at optimized conditions of 25-30  C, pH 9, and using glucose and NH4H2PO4 as carbon and nitrogen source respectively, whereas PsGo consortium decolorized RB-5 (50 mg/mL) completely at 37  C, pH 11, and with lactose and NH4H2PO4 used as carbon and nitrogen sources.	Glucose	138-145	steroid sulfatase	Homo sapiens	21-25
30986666-8	2019	Over longer periods, StSp consortium managed to completely decolorize RB-5 (50 mg/L) at optimized conditions of 25-30  C, pH 9, and using glucose and NH4H2PO4 as carbon and nitrogen source respectively, whereas PsGo consortium decolorized RB-5 (50 mg/mL) completely at 37  C, pH 11, and with lactose and NH4H2PO4 used as carbon and nitrogen sources.	Ammonium dihydrogen phosphate	150-158	steroid sulfatase	Homo sapiens	21-25
30986666-8	2019	Over longer periods, StSp consortium managed to completely decolorize RB-5 (50 mg/L) at optimized conditions of 25-30  C, pH 9, and using glucose and NH4H2PO4 as carbon and nitrogen source respectively, whereas PsGo consortium decolorized RB-5 (50 mg/mL) completely at 37  C, pH 11, and with lactose and NH4H2PO4 used as carbon and nitrogen sources.	Carbon	162-168	steroid sulfatase	Homo sapiens	21-25
30986666-8	2019	Over longer periods, StSp consortium managed to completely decolorize RB-5 (50 mg/L) at optimized conditions of 25-30  C, pH 9, and using glucose and NH4H2PO4 as carbon and nitrogen source respectively, whereas PsGo consortium decolorized RB-5 (50 mg/mL) completely at 37  C, pH 11, and with lactose and NH4H2PO4 used as carbon and nitrogen sources.	Nitrogen	173-181	steroid sulfatase	Homo sapiens	21-25
30986666-8	2019	Over longer periods, StSp consortium managed to completely decolorize RB-5 (50 mg/L) at optimized conditions of 25-30  C, pH 9, and using glucose and NH4H2PO4 as carbon and nitrogen source respectively, whereas PsGo consortium decolorized RB-5 (50 mg/mL) completely at 37  C, pH 11, and with lactose and NH4H2PO4 used as carbon and nitrogen sources.	rb-5	239-243	steroid sulfatase	Homo sapiens	21-25
30986666-8	2019	Over longer periods, StSp consortium managed to completely decolorize RB-5 (50 mg/L) at optimized conditions of 25-30  C, pH 9, and using glucose and NH4H2PO4 as carbon and nitrogen source respectively, whereas PsGo consortium decolorized RB-5 (50 mg/mL) completely at 37  C, pH 11, and with lactose and NH4H2PO4 used as carbon and nitrogen sources.	Lactose	292-299	steroid sulfatase	Homo sapiens	21-25
30986666-8	2019	Over longer periods, StSp consortium managed to completely decolorize RB-5 (50 mg/L) at optimized conditions of 25-30  C, pH 9, and using glucose and NH4H2PO4 as carbon and nitrogen source respectively, whereas PsGo consortium decolorized RB-5 (50 mg/mL) completely at 37  C, pH 11, and with lactose and NH4H2PO4 used as carbon and nitrogen sources.	Ammonium dihydrogen phosphate	304-312	steroid sulfatase	Homo sapiens	21-25
30986666-8	2019	Over longer periods, StSp consortium managed to completely decolorize RB-5 (50 mg/L) at optimized conditions of 25-30  C, pH 9, and using glucose and NH4H2PO4 as carbon and nitrogen source respectively, whereas PsGo consortium decolorized RB-5 (50 mg/mL) completely at 37  C, pH 11, and with lactose and NH4H2PO4 used as carbon and nitrogen sources.	Carbon	321-327	steroid sulfatase	Homo sapiens	21-25
30986666-8	2019	Over longer periods, StSp consortium managed to completely decolorize RB-5 (50 mg/L) at optimized conditions of 25-30  C, pH 9, and using glucose and NH4H2PO4 as carbon and nitrogen source respectively, whereas PsGo consortium decolorized RB-5 (50 mg/mL) completely at 37  C, pH 11, and with lactose and NH4H2PO4 used as carbon and nitrogen sources.	Nitrogen	332-340	steroid sulfatase	Homo sapiens	21-25
30882839-1	2019	An interesting stereo- and chemoselective cyclization reaction of several N-sulfonyl ketimines as C/N-donors with a variety of alpha,beta-unsaturated sulfonyl fluorides promoted by DBU is reported.	n-sulfonyl ketimines	74-94	steroid sulfatase	Homo sapiens	95-99
30882839-1	2019	An interesting stereo- and chemoselective cyclization reaction of several N-sulfonyl ketimines as C/N-donors with a variety of alpha,beta-unsaturated sulfonyl fluorides promoted by DBU is reported.	alpha,beta-unsaturated sulfonyl fluorides	127-168	steroid sulfatase	Homo sapiens	95-99
30882839-1	2019	An interesting stereo- and chemoselective cyclization reaction of several N-sulfonyl ketimines as C/N-donors with a variety of alpha,beta-unsaturated sulfonyl fluorides promoted by DBU is reported.	1,8-diazabicyclo(5.4.0)undec-7-ene	181-184	steroid sulfatase	Homo sapiens	95-99
30542396-2	2018	Steroid sulfatase (STS) is a steroid sulfate activation enzyme, considered to be one of the key enzymes in the androgen signaling pathway.	steroid sulfate	29-44	steroid sulfatase	Homo sapiens	0-17
30262428-3	2018	We already reported a large family of pyrazolo[3,4-d]pyrimidines active as c-Src inhibitors.	pyrazolo(3,4-d)pyrimidine	38-64	steroid sulfatase	Homo sapiens	72-76
29331754-0	2018	Synthesis and bioevaluation and doking study of 1H-pyrrolo[2,3-b]pyridine derivatives bearing aromatic hydrazone moiety as c-Met inhibitors.	pyrrolo(2, 3-b)pyridine	48-73	steroid sulfatase	Homo sapiens	120-124
29440314-1	2018	Steroid hormones can exist in functionally dissociable sulfated and non-sulfated (free) forms and can exert profound effects on numerous aspects of mammalian physiology; the ratio of free-to-sulfated steroids is governed by the antagonistic actions of steroid sulfatase (STS) and sulfotransferase (SULT) enzymes.	Steroids	0-16	steroid sulfatase	Homo sapiens	252-269
29715297-4	2018	Strains resistant to arsenic concentrations varying from 0.5 to 100 mM arsenite or arsenate were isolated and the presence of genes coding for enzymes involved in arsenic oxidation (aio) or reduction (arsC) investigated.	Arsenic	163-170	steroid sulfatase	Homo sapiens	201-205
30119233-4	2018	The UALVopt formulation containing anethole as terpene (1% as A), ethanol (2.6% as B) and phospholipid90 G (8.8 mg as C) showed low PDI (0.212), vesicle size (115.56 nm) and high entrapment efficiency (76.42%).	anethole	35-43	steroid sulfatase	Homo sapiens	115-119
30119233-4	2018	The UALVopt formulation containing anethole as terpene (1% as A), ethanol (2.6% as B) and phospholipid90 G (8.8 mg as C) showed low PDI (0.212), vesicle size (115.56 nm) and high entrapment efficiency (76.42%).	phospholipid90	90-104	steroid sulfatase	Homo sapiens	115-119
30320251-1	2018	Synthetic routes to potent bicyclic nonsteroidal sulfamate-based active-site-directed inhibitors of the enzyme steroid sulfatase (STS), an emerging target in the treatment of postmenopausal hormone-dependent diseases, including breast cancer, are described.	sulfamic acid	49-58	steroid sulfatase	Homo sapiens	111-128
29421713-0	2018	Discovery of thinopyrimidine-triazole conjugates as c-Met targeting and apoptosis inducing agents.	thinopyrimidine-triazole	13-37	steroid sulfatase	Homo sapiens	49-53
29331754-0	2018	Synthesis and bioevaluation and doking study of 1H-pyrrolo[2,3-b]pyridine derivatives bearing aromatic hydrazone moiety as c-Met inhibitors.	aromatic hydrazone	94-112	steroid sulfatase	Homo sapiens	120-124
28795252-0	2017	IPET study: an FLT-PET window study to assess the activity of the steroid sulfatase inhibitor irosustat in early breast cancer.	ipet	0-4	steroid sulfatase	Homo sapiens	66-83
29227648-1	2018	Quinazolinone-based anticancer agents were designed, decorated with functional groups from a 2-methoxyestradiol-based microtubule disruptor series, incorporating the aryl sulfamate motif of steroid sulfatase (STS) inhibitors.	Quinazolinones	0-13	steroid sulfatase	Homo sapiens	190-207
29227648-1	2018	Quinazolinone-based anticancer agents were designed, decorated with functional groups from a 2-methoxyestradiol-based microtubule disruptor series, incorporating the aryl sulfamate motif of steroid sulfatase (STS) inhibitors.	2-Methoxyestradiol	93-111	steroid sulfatase	Homo sapiens	190-207
29227648-1	2018	Quinazolinone-based anticancer agents were designed, decorated with functional groups from a 2-methoxyestradiol-based microtubule disruptor series, incorporating the aryl sulfamate motif of steroid sulfatase (STS) inhibitors.	aryl sulfamate	166-180	steroid sulfatase	Homo sapiens	190-207
29054710-1	2017	The female hormone 17 beta-estradiol (E2) is synthesized from estrone by steroid sulfatase (STS), and metabolized into 2-methoxyestradiol (2-ME), whereby the biological activity of the latter is substantially different from that of E2.	Estradiol	19-36	steroid sulfatase	Homo sapiens	73-90
29211769-9	2017	We then performed quantification by qPCR of two arsenic resistant genes (ArsB, ArsC).	Arsenic	48-55	steroid sulfatase	Homo sapiens	79-83
28795252-0	2017	IPET study: an FLT-PET window study to assess the activity of the steroid sulfatase inhibitor irosustat in early breast cancer.	irosustat	94-103	steroid sulfatase	Homo sapiens	66-83
27531568-0	2016	Role of steroid sulfatase in steroid homeostasis and characterization of the sulfated steroid pathway: Evidence from steroid sulfatase deficiency.	Steroids	29-36	steroid sulfatase	Homo sapiens	8-25
28558969-1	2017	Pyrazolo[3,4-d]pyrimidine derivatives 1-5, active as c-Src inhibitors, have been selected to be formulated as drug-loaded human serum albumin (HSA) nanoparticles, with the aim of improving their solubility and pharmacokinetic properties.	pyrazolo(3,4-d)pyrimidine	0-25	steroid sulfatase	Homo sapiens	50-54
28429243-2	2017	Two major reactions contribute to E1 plasma concentrations, aromatase (CYP19A1) catalyzed E1 synthesis from androstenedione and steroid sulfatase (STS) catalyzed hydrolysis of estrone conjugates (E1Cs).	Estrone	176-183	steroid sulfatase	Homo sapiens	128-145
28032462-0	2017	Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors.	Nitrogen	39-40	steroid sulfatase	Homo sapiens	94-111
28032462-0	2017	Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors.	acylated tyramine sulfamates	41-69	steroid sulfatase	Homo sapiens	94-111
28032462-1	2017	Steroid sulfatase (STS) is responsible for the hydrolysis of biologically inactive sulfated steroids into their active un-sulfated forms and promotes the growth of various hormone-dependent cancers (e.g., breast cancer).	Steroids	92-100	steroid sulfatase	Homo sapiens	0-17
28482050-6	2017	The levels of mRNA encoding key enzymes of bisphenol biotransformation were investigated by quantitative PCR: UGT2B15 UDP (glucuronosyltransferase two family, polypeptide B15), GUSB (glucuronidase beta), SULT1A1 and 3 (sulfotransferase family 1 A member 1 and 3) and STS (steroid sulfatase).	bis(4-hydroxyphenyl)sulfone	43-52	steroid sulfatase	Homo sapiens	272-289
28977889-1	2017	Steroid sulfatase (STS) catalyzes the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate (DHEAS) to their unconjugated biologically active forms.	estrone sulfate	52-67	steroid sulfatase	Homo sapiens	0-17
28977889-1	2017	Steroid sulfatase (STS) catalyzes the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate (DHEAS) to their unconjugated biologically active forms.	Dehydroepiandrosterone Sulfate	72-102	steroid sulfatase	Homo sapiens	0-17
28977889-1	2017	Steroid sulfatase (STS) catalyzes the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate (DHEAS) to their unconjugated biologically active forms.	Dehydroepiandrosterone Sulfate	104-109	steroid sulfatase	Homo sapiens	0-17
27956712-1	2017	Steroid sulfatase (STS) is an enzyme responsible for the hydrolysis of aryl and alkyl sulfates.	aryl and alkyl sulfates	71-94	steroid sulfatase	Homo sapiens	0-17
28152429-0	2017	Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors.	n-benzoyl	51-60	steroid sulfatase	Homo sapiens	140-157
28152429-0	2017	Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors.	n-phenylacetoyl	65-80	steroid sulfatase	Homo sapiens	140-157
28152429-0	2017	Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors.	3-(4-aminophenyl)-coumarin-7-o-sulfamate	96-136	steroid sulfatase	Homo sapiens	140-157
28152429-1	2017	In the present work, we report convenient methods for the synthesis of 3-(4-aminophenyl)-coumarin-7-O-sulfamate derivatives N-acylated with fluorinated analogues of benzoic or phenylacetic acid as steroid sulfatase (STS) inhibitors.	3-(4-aminophenyl)-coumarin-7-o-sulfamate	71-111	steroid sulfatase	Homo sapiens	197-214
28293481-1	2017	INTRODUCTION: The enzyme steroid sulfatase (STS) converts sulfated steroids to their non-sulfated forms.	Steroids	67-75	steroid sulfatase	Homo sapiens	25-42
27531568-1	2016	The impact of steroid sulfatase (STS) activity in the circulating levels of both sulfated and unconjugated steroids is only partially known.	Steroids	107-115	steroid sulfatase	Homo sapiens	14-31
27155470-0	2016	Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties.	sulfamic acid	15-24	steroid sulfatase	Homo sapiens	31-48
27396929-0	2016	Synthesis and biological evaluation of Oblongifolin C derivatives as c-Met inhibitors.	oblongifolin C	39-53	steroid sulfatase	Homo sapiens	66-70
27155470-1	2016	Steroid sulfatase (STS), the enzyme which converts inactive sulfated steroid precursors into active hormones, is a promising therapeutic target for the treatment of estrogen-sensitive breast cancer.	Steroids	69-76	steroid sulfatase	Homo sapiens	0-17
26964675-0	2016	Synthesis, and docking studies of phenylpyrimidine-carboxamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.	phenylpyrimidine-carboxamide	34-62	steroid sulfatase	Homo sapiens	116-120
27143133-0	2016	Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors.	arylamide	52-61	steroid sulfatase	Homo sapiens	120-137
27143133-0	2016	Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors.	sulfonate	85-94	steroid sulfatase	Homo sapiens	120-137
27143133-0	2016	Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors.	sulfamic acid	98-107	steroid sulfatase	Homo sapiens	120-137
27003302-1	2016	CONTEXT: Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including dehydroepiandrosterone (DHEA) sulfate (DHEAS), the inactive sulfate ester of the adrenal androgen precursor DHEA.	Sulfates	45-52	steroid sulfatase	Homo sapiens	9-26
27003302-1	2016	CONTEXT: Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including dehydroepiandrosterone (DHEA) sulfate (DHEAS), the inactive sulfate ester of the adrenal androgen precursor DHEA.	steroid sulfates	64-80	steroid sulfatase	Homo sapiens	9-26
27003302-1	2016	CONTEXT: Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including dehydroepiandrosterone (DHEA) sulfate (DHEAS), the inactive sulfate ester of the adrenal androgen precursor DHEA.	Dehydroepiandrosterone	92-114	steroid sulfatase	Homo sapiens	9-26
27003302-1	2016	CONTEXT: Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including dehydroepiandrosterone (DHEA) sulfate (DHEAS), the inactive sulfate ester of the adrenal androgen precursor DHEA.	Dehydroepiandrosterone Sulfate	116-129	steroid sulfatase	Homo sapiens	9-26
27003302-1	2016	CONTEXT: Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including dehydroepiandrosterone (DHEA) sulfate (DHEAS), the inactive sulfate ester of the adrenal androgen precursor DHEA.	sulfate ester	152-165	steroid sulfatase	Homo sapiens	9-26
27003302-1	2016	CONTEXT: Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including dehydroepiandrosterone (DHEA) sulfate (DHEAS), the inactive sulfate ester of the adrenal androgen precursor DHEA.	Dehydroepiandrosterone	116-120	steroid sulfatase	Homo sapiens	9-26
26950400-0	2016	Design, synthesis and biological evaluation of 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as c-Met inhibitors.	pyrrolo(2, 3-b)pyridine	47-72	steroid sulfatase	Homo sapiens	116-120
26950400-0	2016	Design, synthesis and biological evaluation of 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as c-Met inhibitors.	1H-pyrazolo(3,4-b)pyridine	77-103	steroid sulfatase	Homo sapiens	116-120
26897090-0	2016	Design, synthesis and biological evaluation of novel 4-phenoxy-6,7-disubstituted quinolines possessing (thio)semicarbazones as c-Met kinase inhibitors.	4-phenoxy-6,7-disubstituted quinolines	53-91	steroid sulfatase	Homo sapiens	124-128
26897090-0	2016	Design, synthesis and biological evaluation of novel 4-phenoxy-6,7-disubstituted quinolines possessing (thio)semicarbazones as c-Met kinase inhibitors.	Thiosemicarbazones	103-123	steroid sulfatase	Homo sapiens	124-128
26810712-0	2016	Design, synthesis, and docking studies of phenylpicolinamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.	phenylpicolinamide	42-60	steroid sulfatase	Homo sapiens	114-118
26810712-0	2016	Design, synthesis, and docking studies of phenylpicolinamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.	pyrrolo(2, 3-b)pyridine	81-106	steroid sulfatase	Homo sapiens	114-118
26974384-1	2016	Steroid sulfatase (STS) plays a momentous role in the conversion of sulfated steroids, which are biologically inactive, into biologically active un-sulfated steroid hormones, which support the development and growth of a number of hormone-dependent cancers, including breast cancer.	Steroids	77-85	steroid sulfatase	Homo sapiens	0-17
26974384-1	2016	Steroid sulfatase (STS) plays a momentous role in the conversion of sulfated steroids, which are biologically inactive, into biologically active un-sulfated steroid hormones, which support the development and growth of a number of hormone-dependent cancers, including breast cancer.	Steroids	157-173	steroid sulfatase	Homo sapiens	0-17
26964675-0	2016	Synthesis, and docking studies of phenylpyrimidine-carboxamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.	pyrrolo(2, 3-b)pyridine	83-108	steroid sulfatase	Homo sapiens	116-120
26631368-1	2016	Steroid sulfatase (STS) converts sulfated steroids into active forms in cells.	Steroids	42-50	steroid sulfatase	Homo sapiens	0-17
26526982-6	2016	In conclusion, factors such as c-fos may play a crucial role in the down-regulation of CYP17 and up-regulation of CYP19 in granulosa cells, thereby suppressing androstenedione synthesis.	Androstenedione	160-175	steroid sulfatase	Homo sapiens	28-32
26742884-5	2016	Protein spots of interest were subjected to protein identification by mass spectrometry.In total, 670 protein spots were detected by 2DE, 28 of which showed more than 1.5-fold different intensity (P &lt; 0.05) between the AS-C and AS-N samples.	Nitrogen	234-235	steroid sulfatase	Homo sapiens	222-226
26220752-2	2016	The goal of this study is to determine whether the inflammatory induction of steroid sulfatase (STS), which converts inactive estrogen sulfates to active estrogens, may have contributed to the estrogen excess in chronic liver disease.	estrogen sulfates	126-143	steroid sulfatase	Homo sapiens	77-94
25992880-1	2015	In 1994, following work from this laboratory, it was reported that estrone-3-O-sulfamate irreversibly inhibits a new potential hormone-dependent cancer target steroid sulfatase (STS).	estrone-3-O-sulfamate	67-88	steroid sulfatase	Homo sapiens	159-176
26666359-2	2016	The enzyme steroid sulfatase (STS) cleaves the sulfate group of DHEAS and E1S leading to biosynthesis of endogenous hormones such as testosterone and estrone.	Sulfates	47-54	steroid sulfatase	Homo sapiens	11-28
26666359-2	2016	The enzyme steroid sulfatase (STS) cleaves the sulfate group of DHEAS and E1S leading to biosynthesis of endogenous hormones such as testosterone and estrone.	Estrone	74-77	steroid sulfatase	Homo sapiens	11-28
26666359-2	2016	The enzyme steroid sulfatase (STS) cleaves the sulfate group of DHEAS and E1S leading to biosynthesis of endogenous hormones such as testosterone and estrone.	Testosterone	133-145	steroid sulfatase	Homo sapiens	11-28
26666359-2	2016	The enzyme steroid sulfatase (STS) cleaves the sulfate group of DHEAS and E1S leading to biosynthesis of endogenous hormones such as testosterone and estrone.	Estrone	150-157	steroid sulfatase	Homo sapiens	11-28
26415657-0	2015	Steroid Sulfatase Inhibitors Based on Phosphate and Thiophosphate Flavone Analogs.	Phosphates	38-47	steroid sulfatase	Homo sapiens	0-17
26415657-0	2015	Steroid Sulfatase Inhibitors Based on Phosphate and Thiophosphate Flavone Analogs.	thiophosphate flavone	52-73	steroid sulfatase	Homo sapiens	0-17
26415657-1	2015	A series of phosphate and thiophosphate flavone derivatives were synthesized and biologically evaluated in vitro for inhibition of steroid sulfatase (STS) activity.	thiophosphate flavone	26-47	steroid sulfatase	Homo sapiens	131-148
26435010-6	2015	A tensile strain would induce a p-type-to-n-type Schottky barrier transition for the As-C hetero-sheet, while a compressive strain can cause a Schottky-to-ohmic contact transition in the Sb-C one.	sb-c	187-191	steroid sulfatase	Homo sapiens	85-89
25737303-1	2015	Dasatinib-based therapy is often used as a second-line therapeutic strategy for imatinib-resistance gastrointestinal stromal tumors (GISTs); however, acquired aberrant activation of dasatinib target proteins, such as c-KIT and PDGFRbeta, attenuates the therapeutic efficiency of dasatinib.	Dasatinib	0-9	steroid sulfatase	Homo sapiens	214-218
25843211-1	2015	Estrogen sulfamate derivatives were the first irreversible active-site-directed inhibitors of steroid sulfatase (STS), an emerging drug target for endocrine therapy of hormone dependent diseases that catalyzes inter alia the hydrolysis of estrone sulfate to estrone.	estrogen sulfamate	0-18	steroid sulfatase	Homo sapiens	94-111
25843211-1	2015	Estrogen sulfamate derivatives were the first irreversible active-site-directed inhibitors of steroid sulfatase (STS), an emerging drug target for endocrine therapy of hormone dependent diseases that catalyzes inter alia the hydrolysis of estrone sulfate to estrone.	estrone sulfate	239-254	steroid sulfatase	Homo sapiens	94-111
25843211-1	2015	Estrogen sulfamate derivatives were the first irreversible active-site-directed inhibitors of steroid sulfatase (STS), an emerging drug target for endocrine therapy of hormone dependent diseases that catalyzes inter alia the hydrolysis of estrone sulfate to estrone.	Estrone	239-246	steroid sulfatase	Homo sapiens	94-111
26211459-0	2015	A-ring substituted 17beta-arylsulfonamides of 17beta-aminoestra-1,3,5(10)-trien-3-ol as highly potent reversible inhibitors of steroid sulfatase.	17beta-arylsulfonamides	19-42	steroid sulfatase	Homo sapiens	127-144
26211459-0	2015	A-ring substituted 17beta-arylsulfonamides of 17beta-aminoestra-1,3,5(10)-trien-3-ol as highly potent reversible inhibitors of steroid sulfatase.	UNII-566D62CJB8	46-84	steroid sulfatase	Homo sapiens	127-144
26211459-1	2015	Steroid sulfatase (STS) catalyzes the hydrolysis of the sulfate ester group in biologically inactive sulfated steroids to give biologically active steroids.	sulfate ester	56-69	steroid sulfatase	Homo sapiens	0-17
26211459-1	2015	Steroid sulfatase (STS) catalyzes the hydrolysis of the sulfate ester group in biologically inactive sulfated steroids to give biologically active steroids.	Steroids	110-118	steroid sulfatase	Homo sapiens	0-17
26211459-1	2015	Steroid sulfatase (STS) catalyzes the hydrolysis of the sulfate ester group in biologically inactive sulfated steroids to give biologically active steroids.	Steroids	147-155	steroid sulfatase	Homo sapiens	0-17
26018080-5	2015	Interestingly, only selected members of the Fos family of proteins such as c-Fos and Fra1 were found to cooperate with TAp73 in a c-Jun-dependent manner to transactivate AP-1 target promoters.	tap73	119-124	steroid sulfatase	Homo sapiens	72-76
25827399-0	2015	Enhancing the cellular anti-proliferation activity of pyridazinones as c-met inhibitors using docking analysis.	pyridazinones	54-67	steroid sulfatase	Homo sapiens	68-72
25737303-1	2015	Dasatinib-based therapy is often used as a second-line therapeutic strategy for imatinib-resistance gastrointestinal stromal tumors (GISTs); however, acquired aberrant activation of dasatinib target proteins, such as c-KIT and PDGFRbeta, attenuates the therapeutic efficiency of dasatinib.	Dasatinib	182-191	steroid sulfatase	Homo sapiens	214-218
25737303-1	2015	Dasatinib-based therapy is often used as a second-line therapeutic strategy for imatinib-resistance gastrointestinal stromal tumors (GISTs); however, acquired aberrant activation of dasatinib target proteins, such as c-KIT and PDGFRbeta, attenuates the therapeutic efficiency of dasatinib.	Dasatinib	279-288	steroid sulfatase	Homo sapiens	214-218
25845343-0	2015	Phosphate and thiophosphate biphenyl analogs as steroid sulfatase inhibitors.	Phosphates	0-9	steroid sulfatase	Homo sapiens	48-65
25845343-0	2015	Phosphate and thiophosphate biphenyl analogs as steroid sulfatase inhibitors.	thiophosphoric acid	14-27	steroid sulfatase	Homo sapiens	48-65
25845343-1	2015	In the present work, we report convenient methods for the synthesis and biological evaluation of phosphate and thiophosphate biphenyl derivatives exhibiting steroid sulfatase (STS) activity.	Phosphates	97-106	steroid sulfatase	Homo sapiens	157-174
25845343-1	2015	In the present work, we report convenient methods for the synthesis and biological evaluation of phosphate and thiophosphate biphenyl derivatives exhibiting steroid sulfatase (STS) activity.	thiophosphoric acid	111-124	steroid sulfatase	Homo sapiens	157-174
25845343-1	2015	In the present work, we report convenient methods for the synthesis and biological evaluation of phosphate and thiophosphate biphenyl derivatives exhibiting steroid sulfatase (STS) activity.	derivatives	134-145	steroid sulfatase	Homo sapiens	157-174
25410727-0	2015	In vitro evaluation of a tetrahydroisoquinoline derivative as a steroid sulfatase inhibitor and a selective estrogen receptor modulator.	1,2,3,4-tetrahydroisoquinoline	25-47	steroid sulfatase	Homo sapiens	64-81
25410727-2	2015	In that respect, a new hormone-related approach is the therapeutical inhibition of steroid sulfatase (STS), which converts inactive, sulfated steroids into active hormones.	Steroids	142-150	steroid sulfatase	Homo sapiens	83-100
25068645-5	2014	Treatment with valproic acid, a histone deacetylase inhibitor (HDACi), attenuated mutant ataxin-3-induced cell toxicity and suppression of acetyl histone H3, phosphorylated cAMP-responsive element binding protein (p-CREB) as well as c-Fos expression.	Valproic Acid	15-28	steroid sulfatase	Homo sapiens	230-234
25090961-4	2014	For multiple As adatoms adsorption in close vicinity, ionicity of the As-C bonds are found to decrease to support As-As cohesion; the net result of which is manifested as better binding of dioxygen molecule with them and additional weakening of the O-O bond in the adsorbed state.	Oxygen	189-197	steroid sulfatase	Homo sapiens	70-74
24604234-0	2014	Synergistic effects of E2MATE and norethindrone acetate on steroid sulfatase inhibition: a randomized phase I proof-of-principle clinical study in women of reproductive age.	Estradiol 3-sulfamate	23-29	steroid sulfatase	Homo sapiens	59-76
24604234-0	2014	Synergistic effects of E2MATE and norethindrone acetate on steroid sulfatase inhibition: a randomized phase I proof-of-principle clinical study in women of reproductive age.	Norethindrone Acetate	34-55	steroid sulfatase	Homo sapiens	59-76
25042472-4	2014	The enzyme steroid sulfatase (STS) converts sulfated steroids into active forms in peripheral tissues.	Steroids	53-61	steroid sulfatase	Homo sapiens	11-28
24096484-6	2014	Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.	Arginine	70-73	steroid sulfatase	Homo sapiens	174-178
24096484-6	2014	Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.	Arginine	183-186	steroid sulfatase	Homo sapiens	174-178
26269086-0	2015	Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors.	thiophosphoric acid	39-52	steroid sulfatase	Homo sapiens	87-104
26269086-0	2015	Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors.	coumarin	63-71	steroid sulfatase	Homo sapiens	87-104
25299175-5	2014	The distribution, diversity and abundance of functional genes (including arsC, arrA, aioA, arsB and ACR3) were much higher for the samples containing higher As and Sb concentrations.	Arsenic	157-159	steroid sulfatase	Homo sapiens	73-77
25299175-5	2014	The distribution, diversity and abundance of functional genes (including arsC, arrA, aioA, arsB and ACR3) were much higher for the samples containing higher As and Sb concentrations.	Antimony	164-166	steroid sulfatase	Homo sapiens	73-77
24873414-3	2014	In this work, binary heterogeneous nanocomplexes (termed as C-dots-AuNC) constructed from gold clusters and carbon dots were reported.	Carbon	108-114	steroid sulfatase	Homo sapiens	57-61
24849787-0	2014	Olive phenolics as c-Met inhibitors: (-)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models.	oleocanthal	37-52	steroid sulfatase	Homo sapiens	16-20
24776788-1	2014	We have synthesized and evaluated two self-immobilizing, turn-on fluorescent probes carrying a coumarin molecular framework for imaging intracellular human steroid sulfatase (STS) activity.	coumarin	95-103	steroid sulfatase	Homo sapiens	156-173
24659434-7	2014	The results of high-performance liquid chromatography-hydride generation-atomic fluorescence spectrometry (HPLC-HG-AFS) and gas chromatography-mass spectrometry (GC/MS) analyses proved the cleavage of the As-C bond during the photocatalytic decomposition process by TiO2 and the intermediates of the decomposition.	titanium dioxide	266-270	steroid sulfatase	Homo sapiens	205-209
25494643-6	2014	Results showed that arsC was expressed in HepG2 cells and the expression was upregulated by 3 folds upon arsenate induction.	arsenic acid	105-113	steroid sulfatase	Homo sapiens	20-24
25494643-8	2014	The results indicated that arsC increased the viability of HepG2 cells by 25% in arsenate, but not in arsenite.	arsenic acid	81-89	steroid sulfatase	Homo sapiens	27-31
25494643-9	2014	And the test of reducing ability of stably transfected cells revealed that the concentration of accumulated trivalent arsenic increased by 25% in HepG2-pCI-ArsC cells.	Arsenic	118-125	steroid sulfatase	Homo sapiens	156-160
25494643-12	2014	Taken together, these results demonstrated that prokaryotic arsenic resistant gene arsC integrated successfully into HepG2 genome and enhanced arsenate resistance of HepG2, which brought new insights of arsenic detoxification in mammalian cells.	Arsenic	60-67	steroid sulfatase	Homo sapiens	83-87
25494643-12	2014	Taken together, these results demonstrated that prokaryotic arsenic resistant gene arsC integrated successfully into HepG2 genome and enhanced arsenate resistance of HepG2, which brought new insights of arsenic detoxification in mammalian cells.	arsenic acid	143-151	steroid sulfatase	Homo sapiens	83-87
25494643-12	2014	Taken together, these results demonstrated that prokaryotic arsenic resistant gene arsC integrated successfully into HepG2 genome and enhanced arsenate resistance of HepG2, which brought new insights of arsenic detoxification in mammalian cells.	Arsenic	203-210	steroid sulfatase	Homo sapiens	83-87
24100027-3	2013	ArsB and ArsC, which share a high sequence identity (71%), produce alkylresorcinols and alkylpyrones through aldol condensation and lactonization of the same polyketomethylene intermediate, respectively.	alkylresorcinols and alkylpyrones	67-100	steroid sulfatase	Homo sapiens	9-13
24100027-3	2013	ArsB and ArsC, which share a high sequence identity (71%), produce alkylresorcinols and alkylpyrones through aldol condensation and lactonization of the same polyketomethylene intermediate, respectively.	polyketomethylene	158-175	steroid sulfatase	Homo sapiens	9-13
24100027-5	2013	Trp-281 of ArsB corresponded to Gly-284 of ArsC in the amino acid sequence alignment.	Tryptophan	0-3	steroid sulfatase	Homo sapiens	43-47
24100027-5	2013	Trp-281 of ArsB corresponded to Gly-284 of ArsC in the amino acid sequence alignment.	Glycine	32-35	steroid sulfatase	Homo sapiens	43-47
24100027-7	2013	In contrast, the ArsC G284W mutant synthesized alkylresorcinol with a small amount of alkylpyrone.	alkylresorcinol	47-62	steroid sulfatase	Homo sapiens	17-21
24100027-7	2013	In contrast, the ArsC G284W mutant synthesized alkylresorcinol with a small amount of alkylpyrone.	alkylpyrone	86-97	steroid sulfatase	Homo sapiens	17-21
24100027-8	2013	These results indicate that this amino acid residue (Trp-281 of ArsB or Gly-284 of ArsC) should occupy a critical position for the cyclization specificity of each enzyme.	Tryptophan	53-56	steroid sulfatase	Homo sapiens	83-87
24100027-8	2013	These results indicate that this amino acid residue (Trp-281 of ArsB or Gly-284 of ArsC) should occupy a critical position for the cyclization specificity of each enzyme.	Glycine	72-75	steroid sulfatase	Homo sapiens	83-87
24100027-11	2013	We postulate that the polyketomethylene intermediate can be folded to a suitable form for aldol condensation only in such a relatively narrow cavity of ArsC G284W (and presumably ArsB).	polyketomethylene	22-39	steroid sulfatase	Homo sapiens	152-156
24205341-1	2013	The presence of the arsenic oxidation, reduction, and extrusion genes arsC, arrA, aioA, and acr3 was explored in a range of natural environments in northern Chile, with arsenic concentrations spanning six orders of magnitude.	Arsenic	20-27	steroid sulfatase	Homo sapiens	70-74
24205341-3	2013	Enterobacterial related arsC genes appeared only in the environments with the lowest As concentration, while Firmicutes-like genes were present throughout the range of As concentrations.	Arsenic	85-87	steroid sulfatase	Homo sapiens	24-28
24205341-8	2013	Overall, the environmental distribution of arsenic related genes suggests that the occurrence of different ArsC families provides different degrees of protection against arsenic as previously described in laboratory strains, and that the glutaredoxin (Grx)-linked arsenate reductases related to Enterobacteria do not confer enough arsenic resistance to live above certain levels of As concentrations.	Arsenic	43-50	steroid sulfatase	Homo sapiens	107-111
24205341-8	2013	Overall, the environmental distribution of arsenic related genes suggests that the occurrence of different ArsC families provides different degrees of protection against arsenic as previously described in laboratory strains, and that the glutaredoxin (Grx)-linked arsenate reductases related to Enterobacteria do not confer enough arsenic resistance to live above certain levels of As concentrations.	Arsenic	170-177	steroid sulfatase	Homo sapiens	107-111
24205341-8	2013	Overall, the environmental distribution of arsenic related genes suggests that the occurrence of different ArsC families provides different degrees of protection against arsenic as previously described in laboratory strains, and that the glutaredoxin (Grx)-linked arsenate reductases related to Enterobacteria do not confer enough arsenic resistance to live above certain levels of As concentrations.	Arsenic	170-177	steroid sulfatase	Homo sapiens	107-111