PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23593136-6	2013	The effects of METH administration on locomotor hyperactivity and the impairment of prepulse inhibition were lower in Pdlim5 hetero KO mice than in wild-type mice.	Methamphetamine	15-19	PDZ and LIM domain 5	Mus musculus	118-124
23593136-7	2013	The transient inhibition of PDLIM5 (achieved by blocking the translocation of protein kinase C epsilon before the METH challenge) had a similar effect on behavior.	Methamphetamine	114-118	PDZ and LIM domain 5	Mus musculus	28-34
23593136-8	2013	Pdlim5 hetero KO mice showed increased immobility time in the forced swimming test, which was diminished after the chronic administration of imipramine.	Imipramine	141-151	PDZ and LIM domain 5	Mus musculus	0-6
23593136-9	2013	Chronic METH treatment increased, whereas chronic haloperidol treatment decreased, Pdlim5 mRNA levels in the prefrontal cortex.	Methamphetamine	8-12	PDZ and LIM domain 5	Mus musculus	83-89
23593136-9	2013	Chronic METH treatment increased, whereas chronic haloperidol treatment decreased, Pdlim5 mRNA levels in the prefrontal cortex.	Haloperidol	50-61	PDZ and LIM domain 5	Mus musculus	83-89
23593136-10	2013	Imipramine increased Pdlim5 mRNA levels in the hippocampus.	Imipramine	0-10	PDZ and LIM domain 5	Mus musculus	21-27
16291758-6	2006	We isolated the murine LIM protein HIC-5 (hydrogen peroxide-induced clone 5; also termed ARA-55 (androgen receptor activator of 55 kDa)) and cloned the highly conserved Xenopus homolog.	Hydrogen Peroxide	42-59	PDZ and LIM domain 5	Mus musculus	23-26
20026769-2	2010	LIM and cysteine-rich domains 1 (Lmcd1) is a novel protein that contain 2 LIM domains with regular spacing in the carboxy-terminal region.	Cysteine	8-16	PDZ and LIM domain 5	Mus musculus	74-77
14602809-3	2003	Here we show that the Lim class homeobox gene Lmx1b is required for proper formation of the entire 5-HT system in the hindbrain, as indicated by the loss of expression of genes necessary for serotonin synthesis and transport in Lmx1b null mice.	Serotonin	191-200	PDZ and LIM domain 5	Mus musculus	22-25
15870270-0	2005	The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha.	Phosphatidylinositol 4,5-Diphosphate	32-69	PDZ and LIM domain 5	Mus musculus	4-7
15870270-3	2005	Here we show that the LIM protein Ajuba contributes to the cellular regulation of PI(4,5)P2 levels by interacting with and activating the enzymatic activity of the PI(4)P 5-kinase (PIPKIalpha), the predominant enzyme in the synthesis of PI(4,5)P2, in a migration stimulus-regulated manner.	pi(4,5)p2	82-91	PDZ and LIM domain 5	Mus musculus	22-25
15870270-3	2005	Here we show that the LIM protein Ajuba contributes to the cellular regulation of PI(4,5)P2 levels by interacting with and activating the enzymatic activity of the PI(4)P 5-kinase (PIPKIalpha), the predominant enzyme in the synthesis of PI(4,5)P2, in a migration stimulus-regulated manner.	pi(4,5)p2	237-246	PDZ and LIM domain 5	Mus musculus	22-25
28673718-2	2017	The aim of this study was to complex LIM in beta-cyclodextrin (LIM-betaCD) and then evaluate its antihyperalgesic effect in an animal model of chronic musculoskeletal pain.	betadex	44-61	PDZ and LIM domain 5	Mus musculus	37-40
8665490-1	1996	Previous work by others shows that d-limonene (LIM) inhibits carcinogen-induced lung tumorigenesis in mice and strongly suggests that LIM can inhibit the metabolic activation of nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).	Nitrosamines	178-190	PDZ and LIM domain 5	Mus musculus	47-50
8665490-1	1996	Previous work by others shows that d-limonene (LIM) inhibits carcinogen-induced lung tumorigenesis in mice and strongly suggests that LIM can inhibit the metabolic activation of nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).	Nitrosamines	178-190	PDZ and LIM domain 5	Mus musculus	134-137
8665490-1	1996	Previous work by others shows that d-limonene (LIM) inhibits carcinogen-induced lung tumorigenesis in mice and strongly suggests that LIM can inhibit the metabolic activation of nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	199-245	PDZ and LIM domain 5	Mus musculus	47-50
8665490-1	1996	Previous work by others shows that d-limonene (LIM) inhibits carcinogen-induced lung tumorigenesis in mice and strongly suggests that LIM can inhibit the metabolic activation of nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	199-245	PDZ and LIM domain 5	Mus musculus	134-137
8665490-1	1996	Previous work by others shows that d-limonene (LIM) inhibits carcinogen-induced lung tumorigenesis in mice and strongly suggests that LIM can inhibit the metabolic activation of nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	247-250	PDZ and LIM domain 5	Mus musculus	47-50
8665490-1	1996	Previous work by others shows that d-limonene (LIM) inhibits carcinogen-induced lung tumorigenesis in mice and strongly suggests that LIM can inhibit the metabolic activation of nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	247-250	PDZ and LIM domain 5	Mus musculus	134-137
8665490-5	1996	After administration of LIM, limonene 1,2-oxide, or perillyl alcohol in vivo, significant inhibition of cytochrome P450-mediated metabolites (NNK N-oxide and HPB) was found at 1 and 4 h after administration of monoterpene.	Limonene	29-37	PDZ and LIM domain 5	Mus musculus	24-27
8665490-5	1996	After administration of LIM, limonene 1,2-oxide, or perillyl alcohol in vivo, significant inhibition of cytochrome P450-mediated metabolites (NNK N-oxide and HPB) was found at 1 and 4 h after administration of monoterpene.	7-Oxabicyclo[4.1.0]hept-3-ene	38-47	PDZ and LIM domain 5	Mus musculus	24-27
8665490-5	1996	After administration of LIM, limonene 1,2-oxide, or perillyl alcohol in vivo, significant inhibition of cytochrome P450-mediated metabolites (NNK N-oxide and HPB) was found at 1 and 4 h after administration of monoterpene.	perillyl alcohol	52-68	PDZ and LIM domain 5	Mus musculus	24-27
8665490-5	1996	After administration of LIM, limonene 1,2-oxide, or perillyl alcohol in vivo, significant inhibition of cytochrome P450-mediated metabolites (NNK N-oxide and HPB) was found at 1 and 4 h after administration of monoterpene.	n-oxide	146-153	PDZ and LIM domain 5	Mus musculus	24-27
8665490-5	1996	After administration of LIM, limonene 1,2-oxide, or perillyl alcohol in vivo, significant inhibition of cytochrome P450-mediated metabolites (NNK N-oxide and HPB) was found at 1 and 4 h after administration of monoterpene.	4-hydoxy-1-(3-pyridyl)-1-butanone	158-161	PDZ and LIM domain 5	Mus musculus	24-27
8665490-5	1996	After administration of LIM, limonene 1,2-oxide, or perillyl alcohol in vivo, significant inhibition of cytochrome P450-mediated metabolites (NNK N-oxide and HPB) was found at 1 and 4 h after administration of monoterpene.	Monoterpenes	210-221	PDZ and LIM domain 5	Mus musculus	24-27
1347750-1	1992	A novel cysteine-rich motif, named LIM, has been identified in the homeo box genes lin-11, Isl-1, and mec-3; the mec-3 and lin-11 genes determine cell lineages in Caenorhabditis elegans.	Cysteine	8-16	PDZ and LIM domain 5	Mus musculus	35-38
34368251-0	2021	Metformin Suppresses the Progress of Diabetes-Accelerated Atherosclerosis by Inhibition of Vascular Smooth Muscle Cell Migration Through AMPK-Pdlim5 Pathway.	Metformin	0-9	PDZ and LIM domain 5	Mus musculus	142-148
34368251-4	2021	In order to investigate whether the AMPK-Pdlim5 pathway is involved in the protective function of metformin against atherosclerosis, we utilized ApoE-/- male mice to investigate whether metformin could suppress diabetes-accelerated atherosclerosis by inhibition of VSMC migration via the AMPK-Pdlim5 pathway.	Metformin	98-107	PDZ and LIM domain 5	Mus musculus	41-47
34368251-8	2021	Results: It was found that metformin could induce the phosphorylation of Pdlim5 and inhibit cell migration as a result.	Metformin	27-36	PDZ and LIM domain 5	Mus musculus	73-79
34368251-11	2021	The data of ApoE-/- mice showed that increased plasma lipids and aggravated vascular smooth muscle cell infiltration into the atherosclerotic lesion in diabetic mice were observed Metformin alleviated diabetes-induced metabolic disorders and atherosclerosis and also reduced VSMC infiltration in atherosclerotic plaques, while the Pdlim5 phospho-abolished mutant that carried adenovirus S177A-Pdlim5 undermines the protective function of metformin.	Metformin	180-189	PDZ and LIM domain 5	Mus musculus	331-337
34368251-11	2021	The data of ApoE-/- mice showed that increased plasma lipids and aggravated vascular smooth muscle cell infiltration into the atherosclerotic lesion in diabetic mice were observed Metformin alleviated diabetes-induced metabolic disorders and atherosclerosis and also reduced VSMC infiltration in atherosclerotic plaques, while the Pdlim5 phospho-abolished mutant that carried adenovirus S177A-Pdlim5 undermines the protective function of metformin.	Metformin	438-447	PDZ and LIM domain 5	Mus musculus	331-337
34368251-11	2021	The data of ApoE-/- mice showed that increased plasma lipids and aggravated vascular smooth muscle cell infiltration into the atherosclerotic lesion in diabetic mice were observed Metformin alleviated diabetes-induced metabolic disorders and atherosclerosis and also reduced VSMC infiltration in atherosclerotic plaques, while the Pdlim5 phospho-abolished mutant that carried adenovirus S177A-Pdlim5 undermines the protective function of metformin.	Metformin	438-447	PDZ and LIM domain 5	Mus musculus	393-399
34368251-12	2021	Conclusions: The activation of the AMPK-Pdlim5 pathway by metformin could interrupt the migratory machine of VSMCs and inhibit cell migration in vitro and in vivo.	Metformin	58-67	PDZ and LIM domain 5	Mus musculus	40-46
30642915-6	2019	SDS-PAGE analysis demonstrated that the expression of beta-myosin heavy chain is increased in ENH -/- mouse myocardium, which could partially, but not completely, account for the depression in tension redevelopment kinetics.	Sodium Dodecyl Sulfate	0-3	PDZ and LIM domain 5	Mus musculus	94-97
29228678-3	2017	ONCOMINE microarray data mining showed that PDLIM5 was closely correlated with the prognosis of PCa in terms of Gleason score, tumor metastasis and biochemical recurrence.	oncomine	0-8	PDZ and LIM domain 5	Mus musculus	44-50
2513327-6	1989	Purification was achieved via DNA-affinity chromatography on a multimerized oligonucleotide representing the Enh2 region from the LTR of the mouse genomic IAP element, MIA14.	Oligonucleotides	76-91	PDZ and LIM domain 5	Mus musculus	109-113
31666122-0	2019	LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force.	Calcium	79-86	PDZ and LIM domain 5	Mus musculus	0-3
30547280-1	2019	The purpose of this study was to examine the protective effects of intracellular homogeneous melanin produced by Lachnum YM156 (LIM) against ultraviolet B (UVB) induced damage in mice.	Melanins	93-100	PDZ and LIM domain 5	Mus musculus	128-131
30547280-3	2019	The LIM was modified by arginine to improve its water solubility and biological activities.	Arginine	24-32	PDZ and LIM domain 5	Mus musculus	4-7
30547280-3	2019	The LIM was modified by arginine to improve its water solubility and biological activities.	Water	48-53	PDZ and LIM domain 5	Mus musculus	4-7
28673718-2	2017	The aim of this study was to complex LIM in beta-cyclodextrin (LIM-betaCD) and then evaluate its antihyperalgesic effect in an animal model of chronic musculoskeletal pain.	betadex	44-61	PDZ and LIM domain 5	Mus musculus	63-66
28673718-7	2017	After induction of hyperalgesia, the oral administration of LIM-betaCD (50mg/kg) significantly increased the paw withdrawal threshold compared to uncomplexed limonene.	Limonene	158-166	PDZ and LIM domain 5	Mus musculus	60-63
28673718-10	2017	After intraplantar administration of capsaicin, LIM was able to significantly decrease time to lick.	Capsaicin	37-46	PDZ and LIM domain 5	Mus musculus	48-51
28673718-12	2017	These results suggest the possible applicability of LIM, uncomplexed or complexed with betaCD, in conditions such as FM and neuropathic pain, for which there are currently only limited pharmacological options.	betadex	87-93	PDZ and LIM domain 5	Mus musculus	52-55
30108807-1	2017	This study aimed to elucidate the therapeutic effects of oral administration of intracellular melanin from Lachnum YM156 (LIM) on chronic renal failure (CRF) in mice.	Melanins	94-101	PDZ and LIM domain 5	Mus musculus	122-125
30108807-1	2017	This study aimed to elucidate the therapeutic effects of oral administration of intracellular melanin from Lachnum YM156 (LIM) on chronic renal failure (CRF) in mice.	lachnum ym156	107-120	PDZ and LIM domain 5	Mus musculus	122-125
30108807-2	2017	The cytotoxicity of LIM was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.	thiazolyl blue	48-108	PDZ and LIM domain 5	Mus musculus	20-23
30108807-2	2017	The cytotoxicity of LIM was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.	monooxyethylene trimethylolpropane tristearate	110-113	PDZ and LIM domain 5	Mus musculus	20-23
30108807-7	2017	The mechanism of the reported salutary effects of LIM in adenine-induced CRF is associated with amelioration of the adenine induced inflammation and oxidative stress.	Adenine	57-64	PDZ and LIM domain 5	Mus musculus	50-53
30108807-7	2017	The mechanism of the reported salutary effects of LIM in adenine-induced CRF is associated with amelioration of the adenine induced inflammation and oxidative stress.	Adenine	116-123	PDZ and LIM domain 5	Mus musculus	50-53
26965372-7	2016	Furthermore, Ssdp1/2 recruit histone-modifying enzymes to the motor neuron-specifying LIM complex and trigger acetylation and lysine 4 trimethylation of histone H3, which are well-established chromatin marks for active transcription.	Lysine	126-132	PDZ and LIM domain 5	Mus musculus	86-89