PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
26559461-2	2016	FGF10 specifically activates FGFR2b in a paracrine manner with heparan sulfate as a co-factor.	Heparitin Sulfate	63-78	fibroblast growth factor 10	Mus musculus	0-5
28387977-3	2017	Fibroblast growth factor 10-positive (FGF10+ ) cells, originally residing in the submesothelial mesenchyme, contribute to ASMC formation in the distal lung.	asmc	122-126	fibroblast growth factor 10	Mus musculus	0-27
28387977-3	2017	Fibroblast growth factor 10-positive (FGF10+ ) cells, originally residing in the submesothelial mesenchyme, contribute to ASMC formation in the distal lung.	asmc	122-126	fibroblast growth factor 10	Mus musculus	38-43
27771497-6	2016	We demonstrated that exogenous RA had negative effects on incisor SCs and that this was accompanied by downregulation of Fgf10, a mesenchymally expressed SC survival factor in the mouse incisor.	Tretinoin	31-33	fibroblast growth factor 10	Mus musculus	121-126
27771497-7	2016	Supplement of Fgf10 in incisor cultures completely blocked RA effects by antagonizing apoptosis and increasing proliferation in LaCL epithelial SCs.	Tretinoin	59-61	fibroblast growth factor 10	Mus musculus	14-19
27771497-8	2016	In addition, Fgf10 obviously antagonized RA-induced downregulation of the SC marker Sox2 in incisor epithelial SCs.	Tretinoin	41-43	fibroblast growth factor 10	Mus musculus	13-18
27771497-9	2016	Our findings suggest that the negative effects of RA on incisor SCs result from inhibition of mesenchymal Fgf10.	Tretinoin	50-52	fibroblast growth factor 10	Mus musculus	106-111
32896382-11	2020	Furthermore, luciferase reporter assay confirmed that FGF10 is the direct target gene of miR-130.	mir-130	89-96	fibroblast growth factor 10	Mus musculus	54-59
33195211-4	2020	We used transgenic mice allowing to transiently inhibit endogenous fibroblast growth factor 10 (Fgf10) activity in mutant embryos at E9, E9.5, and E11 upon intraperitoneal exposure to doxycycline and examined the resulting lung phenotype at later developmental stages.	Doxycycline	184-195	fibroblast growth factor 10	Mus musculus	67-94
33195211-4	2020	We used transgenic mice allowing to transiently inhibit endogenous fibroblast growth factor 10 (Fgf10) activity in mutant embryos at E9, E9.5, and E11 upon intraperitoneal exposure to doxycycline and examined the resulting lung phenotype at later developmental stages.	Doxycycline	184-195	fibroblast growth factor 10	Mus musculus	96-101
33440393-5	2020	Secondly, FGF10 levels were elevated in mice after TBI, whereas intraventricular injection of Ad-FGF10 decreased mNSS score and brain water content, indicating the remittance of neurological deficit and cerebral edema in TBI mice.	Water	134-139	fibroblast growth factor 10	Mus musculus	97-102
30515795-8	2019	Inhibition of miR-129-5p is able to increase the antioxidant capacity, EGFR-positive rate and the expressions of EGFR, B-cell lymphoma-2, zonula occluden-1, occludin, and keratinocyte growth factor-2, but decrease the expression of vascular endothelial growth factor, BCL2-associated X protein, interleukin (IL)-1beta, and IL-4.	mir-129-5p	14-24	fibroblast growth factor 10	Mus musculus	171-199
30728831-1	2018	This study demonstrates that FGF10/FGFR2b signaling on distal epithelial progenitor cells, via ss-catenin/EP300, controls, through a comprehensive set of developmental genes, morphogenesis, and differentiation.	ss-catenin	95-105	fibroblast growth factor 10	Mus musculus	29-34
30728831-4	2018	Through the use of a dominant negative transgenic mouse model (Rosa26rtTA; tet(o)sFgfr2b), we conditionally inhibited FGF10 signaling in vivo in E12.5 embryonic lungs via doxycycline IP injection to pregnant females, and in vitro by culturing control and experimental lungs with doxycycline.	tetramethylenedisulfotetramine	75-78	fibroblast growth factor 10	Mus musculus	118-123
30728831-4	2018	Through the use of a dominant negative transgenic mouse model (Rosa26rtTA; tet(o)sFgfr2b), we conditionally inhibited FGF10 signaling in vivo in E12.5 embryonic lungs via doxycycline IP injection to pregnant females, and in vitro by culturing control and experimental lungs with doxycycline.	Doxycycline	171-182	fibroblast growth factor 10	Mus musculus	118-123
30728831-4	2018	Through the use of a dominant negative transgenic mouse model (Rosa26rtTA; tet(o)sFgfr2b), we conditionally inhibited FGF10 signaling in vivo in E12.5 embryonic lungs via doxycycline IP injection to pregnant females, and in vitro by culturing control and experimental lungs with doxycycline.	Doxycycline	279-290	fibroblast growth factor 10	Mus musculus	118-123
30728831-7	2018	The relationship between FGF10 and ss-catenin signaling was also analyzed through in vitro experiments using IQ1, a pharmacological inhibitor of ss-catenin/EP300 transcriptional activity.	ss-catenin	35-45	fibroblast growth factor 10	Mus musculus	25-30
30728831-13	2018	This study demonstrates that FGF10/FGFR2b signaling on distal epithelial progenitor cells via ss-catenin/EP300 controls, through a comprehensive set of developmental genes, cell adhesion, and differentiation.	ss-catenin	94-104	fibroblast growth factor 10	Mus musculus	29-34
30425728-5	2018	FGF10 is a typical paracrine FGF and chiefly mediates biological responses by activating FGFR2b with heparin/heparan sulfate (HS) as cofactor.	Heparin	101-108	fibroblast growth factor 10	Mus musculus	0-5
30425728-5	2018	FGF10 is a typical paracrine FGF and chiefly mediates biological responses by activating FGFR2b with heparin/heparan sulfate (HS) as cofactor.	Heparin	101-108	fibroblast growth factor 10	Mus musculus	0-3
30425728-5	2018	FGF10 is a typical paracrine FGF and chiefly mediates biological responses by activating FGFR2b with heparin/heparan sulfate (HS) as cofactor.	Heparitin Sulfate	109-124	fibroblast growth factor 10	Mus musculus	0-5
30425728-5	2018	FGF10 is a typical paracrine FGF and chiefly mediates biological responses by activating FGFR2b with heparin/heparan sulfate (HS) as cofactor.	Heparitin Sulfate	109-124	fibroblast growth factor 10	Mus musculus	0-3
30425728-5	2018	FGF10 is a typical paracrine FGF and chiefly mediates biological responses by activating FGFR2b with heparin/heparan sulfate (HS) as cofactor.	hassio	126-128	fibroblast growth factor 10	Mus musculus	0-5
30425728-5	2018	FGF10 is a typical paracrine FGF and chiefly mediates biological responses by activating FGFR2b with heparin/heparan sulfate (HS) as cofactor.	hassio	126-128	fibroblast growth factor 10	Mus musculus	0-3
28396518-7	2017	Mechanistic studies showed that rapamycin inhibits Wnt/beta-catenin and Notch signaling but promotes the expression of fibroblast growth factor (Fgf8), Fgf10, and Nodal at early stage, and bone morphogenetic protein 2 (Bmp 2) at later stages.	Sirolimus	32-41	fibroblast growth factor 10	Mus musculus	152-157
25446127-3	2015	Here, we investigated the potential effect of FGF10, a member of FGFs, on neuron survival in oxygen-glucose deprivation (OGD) model.	oxygen-glucose	93-107	fibroblast growth factor 10	Mus musculus	46-51
26813160-2	2016	We previously showed that FGF10 protects neuron against oxygen-glucose deprivation injury in vitro; however, the effect of FGF10 in ischemic stroke in vivo is unknown.	Oxygen	56-62	fibroblast growth factor 10	Mus musculus	26-31
26813160-8	2016	Blockade of PI3K/Akt signaling pathway by wortmannin and Akt1/2-kinase inhibitor, partly compromised the neuroprotection of FGF10.	Wortmannin	42-52	fibroblast growth factor 10	Mus musculus	124-129
25820524-2	2015	Lung epithelial cell overexpression of Fgf10 postbleomycin injury is both protective and therapeutic, characterized by increased survival and attenuated fibrosis.	postbleomycin	45-58	fibroblast growth factor 10	Mus musculus	39-44
23468377-7	2016	These were implanted into the omentum of NOD/SCID gamma-chain-deficient mice and induced with doxycycline in the case of tet(o)Fgf10/(-).	Doxycycline	94-105	fibroblast growth factor 10	Mus musculus	127-132
24832898-6	2014	In the presence of heparin, a well-known activator of FGF signaling, cystic morphology with lumen expansion was observed in cultures containing FGF1, FGF7, or FGF10, but growth arrest was observed in cultures containing FGF2 or FGF9.	Heparin	19-26	fibroblast growth factor 10	Mus musculus	159-164
24730525-2	2014	Fgf10 mediates biological responses by activating Fgf receptor 2b (Fgfr2b) with heparin/heparan sulfate in a paracrine manner.	Heparin	80-87	fibroblast growth factor 10	Mus musculus	0-5
24730525-2	2014	Fgf10 mediates biological responses by activating Fgf receptor 2b (Fgfr2b) with heparin/heparan sulfate in a paracrine manner.	Heparitin Sulfate	88-103	fibroblast growth factor 10	Mus musculus	0-5
22972683-6	2012	In cultured MLE-12 lung epithelial cells, blebbistatin increased cell velocity, but left the migratory response to FGF-10 unchanged.	blebbistatin	42-54	fibroblast growth factor 10	Mus musculus	115-121
24011590-4	2013	By combining mass-spectrometry-based quantitative proteomics with fluorescence microscopy and biochemical methods, we find that FGF-10 specifically induces the rapid phosphorylation of tyrosine (Y) 734 on FGFR2b, which leads to PI3K and SH3BP4 recruitment.	Tyrosine	185-193	fibroblast growth factor 10	Mus musculus	128-134
23967208-3	2013	After naphthalene, ozone or bleomycin-induced airway epithelial injury, surviving epithelial cells secrete Wnt7b which then activates the PSMC niche to induce Fgf10 expression.	Bleomycin	28-37	fibroblast growth factor 10	Mus musculus	159-164
23967208-6	2013	However, in the adult lung we show that after naphthalene-mediated airway epithelial injury c-Myc is important for the activation of the PSMC niche and as such induces proliferation and Fgf10 expression in PSMCs.	naphthalene	46-57	fibroblast growth factor 10	Mus musculus	186-191
23259863-7	2012	Recently we have further shown that FGF10 signaling, a process that is necessary for distal lung morphogenesis, can also antagonize bleomycin-induced lung fibrosis in adult mice by a mechanism involving inhibition of active TGF beta ligand bioavailability.	Bleomycin	132-141	fibroblast growth factor 10	Mus musculus	36-41
20717994-6	2011	Molecular analysis revealed corticosterone-induced increase in expression of stromal growth factor Fgf10 which, together with prominent stromal GR expression, suggest that glucocorticoid modify stromal-to-epithelial signaling in the mouse prostate.	Corticosterone	28-42	fibroblast growth factor 10	Mus musculus	99-104
22719891-6	2012	However, administration of tamoxifen to Fgf10(iCre); Tomato(flox) double transgenic embryos or adult mice results in specific labeling of Fgf10-positive cells, which can be lineage-traced temporally and spatially.	Tamoxifen	27-36	fibroblast growth factor 10	Mus musculus	40-45
22719891-6	2012	However, administration of tamoxifen to Fgf10(iCre); Tomato(flox) double transgenic embryos or adult mice results in specific labeling of Fgf10-positive cells, which can be lineage-traced temporally and spatially.	Tamoxifen	27-36	fibroblast growth factor 10	Mus musculus	138-143
21492869-4	2012	This suggests that the retinoic acid (RA) signaling pathway interacts with the Fgf10-Fgfr2IIIb signaling pathway during duodenal development.	Tretinoin	23-36	fibroblast growth factor 10	Mus musculus	79-84
21492869-4	2012	This suggests that the retinoic acid (RA) signaling pathway interacts with the Fgf10-Fgfr2IIIb signaling pathway during duodenal development.	Tretinoin	38-40	fibroblast growth factor 10	Mus musculus	79-84
21696361-3	2011	FGF10 mediates biological responses by activating FGF receptor 2b (FGFR2b) with heparin/heparan sulfate in a paracrine manner.	Heparin	80-87	fibroblast growth factor 10	Mus musculus	0-5
21696361-3	2011	FGF10 mediates biological responses by activating FGF receptor 2b (FGFR2b) with heparin/heparan sulfate in a paracrine manner.	Heparitin Sulfate	88-103	fibroblast growth factor 10	Mus musculus	0-5
21985786-3	2011	Here, we report that this Wnt/Fgf10 embryonic signaling cascade is reactivated in mature PSMCs after naphthalene-induced injury to airway epithelium.	psmcs	89-94	fibroblast growth factor 10	Mus musculus	30-35
21985786-3	2011	Here, we report that this Wnt/Fgf10 embryonic signaling cascade is reactivated in mature PSMCs after naphthalene-induced injury to airway epithelium.	naphthalene	101-112	fibroblast growth factor 10	Mus musculus	30-35
21985786-5	2011	After naphthalene injury, PSMCs secreted Fgf10 to activate Notch signaling and induce Snai1 expression in surviving variant Clara cells, which subsequently underwent a transient epithelial to mesenchymal transition to initiate the repair process.	psmcs	26-31	fibroblast growth factor 10	Mus musculus	41-46
21427903-5	2011	RESULTS: (1) Gene-chip analysis showed that in RA-induced cleft palate group wnt8a and fgf9 were down-regulated, wnt3 and fgf10 were up-regulated in conversely.	Tretinoin	47-49	fibroblast growth factor 10	Mus musculus	122-127
21179697-0	2010	[Effects of dexamethasone and vitamin B12 on expression of fibroblast growth factor 10 and fibroblast growth factor receptor 2b during early palatogenesis].	Dexamethasone	12-25	fibroblast growth factor 10	Mus musculus	59-86
21203390-8	2010	FGF-10 also increased mouse iPS cell differentiation into cardiomyocyte lineage, and this effect was abolished by FGF-10 neutralizing antibody or PD173074.	PD 173074	146-154	fibroblast growth factor 10	Mus musculus	0-6
21179697-0	2010	[Effects of dexamethasone and vitamin B12 on expression of fibroblast growth factor 10 and fibroblast growth factor receptor 2b during early palatogenesis].	Vitamin B 12	30-41	fibroblast growth factor 10	Mus musculus	59-86
21179697-1	2010	OBJECTIVE: To observe the alteration of fibroblast growth factor 10 (Fgf10) and fibroblast growth factor receptor 2 (Fgfr2b) signal in mouse embryonic palate after dexamethasone and vitamin B12 exposure.	Dexamethasone	164-177	fibroblast growth factor 10	Mus musculus	40-67
21179697-1	2010	OBJECTIVE: To observe the alteration of fibroblast growth factor 10 (Fgf10) and fibroblast growth factor receptor 2 (Fgfr2b) signal in mouse embryonic palate after dexamethasone and vitamin B12 exposure.	Dexamethasone	164-177	fibroblast growth factor 10	Mus musculus	69-74
21179697-1	2010	OBJECTIVE: To observe the alteration of fibroblast growth factor 10 (Fgf10) and fibroblast growth factor receptor 2 (Fgfr2b) signal in mouse embryonic palate after dexamethasone and vitamin B12 exposure.	Vitamin B 12	182-193	fibroblast growth factor 10	Mus musculus	40-67
21179697-1	2010	OBJECTIVE: To observe the alteration of fibroblast growth factor 10 (Fgf10) and fibroblast growth factor receptor 2 (Fgfr2b) signal in mouse embryonic palate after dexamethasone and vitamin B12 exposure.	Vitamin B 12	182-193	fibroblast growth factor 10	Mus musculus	69-74
21179697-5	2010	RESULTS: Fgf10 and Fgfr2b expression was down-regulated and mesenchymal cells proliferation was inhibited significantly after dexamethasone exposure.	Dexamethasone	126-139	fibroblast growth factor 10	Mus musculus	9-14
21179697-6	2010	After vitamin B12 treatment, Fgf10 and Fgfr2b expression did not restore, but cells proliferation was recovered.	Vitamin B 12	6-17	fibroblast growth factor 10	Mus musculus	29-34
21179697-7	2010	CONCLUSION: Dexamethasone and vitamin B12 affected the expression of Fgf10 and Fgfr2b of mouse embryonic palate and mesenchyme cells proliferation, but the change was disaccord.	Dexamethasone	12-25	fibroblast growth factor 10	Mus musculus	69-74
21179697-7	2010	CONCLUSION: Dexamethasone and vitamin B12 affected the expression of Fgf10 and Fgfr2b of mouse embryonic palate and mesenchyme cells proliferation, but the change was disaccord.	Vitamin B 12	30-41	fibroblast growth factor 10	Mus musculus	69-74
20920724-0	2010	Perturbation of Fgf10 signal pathway in mouse embryonic palate by dexamethasone and vitamin B12 in vivo.	Dexamethasone	66-79	fibroblast growth factor 10	Mus musculus	16-21
19551815-12	2009	Moreover, the activation level of pERK1 was dramatically increased by exogenous FGF10 alone and by combined treatment with FGF10 and U0126.	U 0126	133-138	fibroblast growth factor 10	Mus musculus	80-85
19805408-0	2010	2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits fibroblast growth factor 10-induced prostatic bud formation in mouse urogenital sinus.	Polychlorinated Dibenzodioxins	0-35	fibroblast growth factor 10	Mus musculus	45-72
19805408-3	2010	The purpose of this study was to determine whether inhibition of fibroblast growth factor 10 (FGF10) signaling is mechanistically linked to mouse prostatic budding impairment by TCDD.	Polychlorinated Dibenzodioxins	178-182	fibroblast growth factor 10	Mus musculus	65-92
19805408-3	2010	The purpose of this study was to determine whether inhibition of fibroblast growth factor 10 (FGF10) signaling is mechanistically linked to mouse prostatic budding impairment by TCDD.	Polychlorinated Dibenzodioxins	178-182	fibroblast growth factor 10	Mus musculus	94-99
19805408-4	2010	In utero TCDD exposure induced aryl hydrocarbon receptor-responsive cytochrome P450 1b1 messenger RNA (mRNA) in ventral UGS regions where Fgf10 and fibroblast growth factor receptor 2 (Fgfr2) mRNA were expressed and where budding was most severely inhibited by TCDD.	Polychlorinated Dibenzodioxins	9-13	fibroblast growth factor 10	Mus musculus	138-143
19805408-7	2010	FGF10 also increased the number of 5-bromo-2"-deoxyuridine (BrdU)-labeled UGS epithelial cells and increased the number of prostatic buds formed per UGS.	Bromodeoxyuridine	35-58	fibroblast growth factor 10	Mus musculus	0-5
19805408-7	2010	FGF10 also increased the number of 5-bromo-2"-deoxyuridine (BrdU)-labeled UGS epithelial cells and increased the number of prostatic buds formed per UGS.	Bromodeoxyuridine	60-64	fibroblast growth factor 10	Mus musculus	0-5
19805408-8	2010	Addition of TCDD to UGS organ culture media did not alter FGF10-induced ERK activation in UGS basal epithelium but prevented FGF10-induced BrdU incorporation and blocked FGF10-induced prostatic bud formation.	Polychlorinated Dibenzodioxins	12-16	fibroblast growth factor 10	Mus musculus	125-130
19805408-8	2010	Addition of TCDD to UGS organ culture media did not alter FGF10-induced ERK activation in UGS basal epithelium but prevented FGF10-induced BrdU incorporation and blocked FGF10-induced prostatic bud formation.	Polychlorinated Dibenzodioxins	12-16	fibroblast growth factor 10	Mus musculus	125-130
19805408-8	2010	Addition of TCDD to UGS organ culture media did not alter FGF10-induced ERK activation in UGS basal epithelium but prevented FGF10-induced BrdU incorporation and blocked FGF10-induced prostatic bud formation.	Bromodeoxyuridine	139-143	fibroblast growth factor 10	Mus musculus	125-130
19805408-8	2010	Addition of TCDD to UGS organ culture media did not alter FGF10-induced ERK activation in UGS basal epithelium but prevented FGF10-induced BrdU incorporation and blocked FGF10-induced prostatic bud formation.	Bromodeoxyuridine	139-143	fibroblast growth factor 10	Mus musculus	125-130
20920724-0	2010	Perturbation of Fgf10 signal pathway in mouse embryonic palate by dexamethasone and vitamin B12 in vivo.	Vitamin B 12	84-95	fibroblast growth factor 10	Mus musculus	16-21
20920724-2	2010	The objective of this study was to assess whether dexamethasone and vitamin B(12) affected the Fgf10 signal pathway of mouse embryonic palate.	Dexamethasone	50-63	fibroblast growth factor 10	Mus musculus	95-100
20920724-2	2010	The objective of this study was to assess whether dexamethasone and vitamin B(12) affected the Fgf10 signal pathway of mouse embryonic palate.	Niacinamide	68-77	fibroblast growth factor 10	Mus musculus	95-100
20920724-4	2010	RESULTS: The expression of Fgf10, Fgfr2b, and sonic hedgehog was changed in mouse embryonic palate after dexamethasone and vitamin B(12) treatment, resulting in reduced and restored proliferation of mesenchymal cells.	Dexamethasone	105-118	fibroblast growth factor 10	Mus musculus	27-32
20920724-4	2010	RESULTS: The expression of Fgf10, Fgfr2b, and sonic hedgehog was changed in mouse embryonic palate after dexamethasone and vitamin B(12) treatment, resulting in reduced and restored proliferation of mesenchymal cells.	Niacinamide	123-132	fibroblast growth factor 10	Mus musculus	27-32
20920724-5	2010	CONCLUSIONS: Dexamethasone and vitamin B(12) affected the Fgf10 signaling pathway and cell proliferation of mouse embryonic palate.	Dexamethasone	13-26	fibroblast growth factor 10	Mus musculus	58-63
20920724-5	2010	CONCLUSIONS: Dexamethasone and vitamin B(12) affected the Fgf10 signaling pathway and cell proliferation of mouse embryonic palate.	Niacinamide	31-40	fibroblast growth factor 10	Mus musculus	58-63
20484817-4	2010	Here, we present evidence that endogenous RA acts as a major regulatory signal integrating Wnt and Tgfbeta pathways in the control of Fgf10 expression during induction of the mouse primordial lung.	Tretinoin	42-44	fibroblast growth factor 10	Mus musculus	134-139
19855977-0	2010	Fgf10 gene expression is delayed in the embryonic lung mesenchyme in the adriamycin mouse model.	Doxorubicin	73-83	fibroblast growth factor 10	Mus musculus	0-5
19855977-5	2010	The aim of this study was to investigate the temporo-spatial expression of Fgf10 during the critical period of separation of the trachea and esophagus in normal and adriamycin-treated embryos using OPT.	Doxorubicin	165-175	fibroblast growth factor 10	Mus musculus	75-80
19855977-13	2010	However, Fgf10 gene expression in adriamycin-treated embryos was first only observed at TS18 in 67% of the specimens.	Doxorubicin	34-44	fibroblast growth factor 10	Mus musculus	9-14
19855977-14	2010	CONCLUSION: Delayed Fgf10 gene expression during the critical period of separation of the trachea and esophagus may affect lung bud formation in the adriamycin model leading to tracheoesophageal malformations.	Doxorubicin	149-159	fibroblast growth factor 10	Mus musculus	20-25
19498056-0	2009	Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice.	Bleomycin	102-111	fibroblast growth factor 10	Mus musculus	18-45
19498056-2	2009	OBJECTIVES: To test for the protective and regenerative effect of Fgf10 overexpression in a bleomycin-induced mouse model of pulmonary inflammation and fibrosis.	Bleomycin	92-101	fibroblast growth factor 10	Mus musculus	66-71
19498056-3	2009	METHODS: In SP-C-rtTA; tet(O)Fgf10 double-transgenic mice, lung fibrosis was induced in 2-month-old transgenic mice by subcutaneous delivery of bleomycin (BLM), using an osmotic minipump for 1 week.	Bleomycin	144-153	fibroblast growth factor 10	Mus musculus	29-34
19498056-3	2009	METHODS: In SP-C-rtTA; tet(O)Fgf10 double-transgenic mice, lung fibrosis was induced in 2-month-old transgenic mice by subcutaneous delivery of bleomycin (BLM), using an osmotic minipump for 1 week.	sp-c-rtta	12-21	fibroblast growth factor 10	Mus musculus	29-34
19498056-4	2009	Exogenous Fgf10 expression in the alveolar epithelium was induced for 7 days with doxycycline during the first, second, and third weeks after bleomycin pump implantation, and lungs were examined at 28 days.	Doxycycline	82-93	fibroblast growth factor 10	Mus musculus	10-15
19498056-4	2009	Exogenous Fgf10 expression in the alveolar epithelium was induced for 7 days with doxycycline during the first, second, and third weeks after bleomycin pump implantation, and lungs were examined at 28 days.	Bleomycin	142-151	fibroblast growth factor 10	Mus musculus	10-15
19498056-9	2009	CONCLUSIONS: In the bleomycin model of lung inflammation and fibrosis, Fgf10 overexpression during both the inflammatory and fibrotic phases results in a greatly reduced extent of lung fibrosis, suggesting that FGF10 may be useful as a novel approach to the treatment of pulmonary fibrosis.	Bleomycin	20-29	fibroblast growth factor 10	Mus musculus	71-76
19498056-9	2009	CONCLUSIONS: In the bleomycin model of lung inflammation and fibrosis, Fgf10 overexpression during both the inflammatory and fibrotic phases results in a greatly reduced extent of lung fibrosis, suggesting that FGF10 may be useful as a novel approach to the treatment of pulmonary fibrosis.	Bleomycin	20-29	fibroblast growth factor 10	Mus musculus	211-216
18230614-0	2008	Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation.	Heparitin Sulfate	9-24	fibroblast growth factor 10	Mus musculus	45-50
18985730-3	2009	In mesenchyme-free, Matrigel-embedded cultures, EGF + lysophosphatidic acid (LPA) induced branching in E13 epithelium, whereas E12 epithelium remained spherical and no branching occurred under the same culture conditions; however, both E12 and E13 epithelia elongated in response to FGF10.	lysophosphatidic acid	54-75	fibroblast growth factor 10	Mus musculus	283-288
18985730-3	2009	In mesenchyme-free, Matrigel-embedded cultures, EGF + lysophosphatidic acid (LPA) induced branching in E13 epithelium, whereas E12 epithelium remained spherical and no branching occurred under the same culture conditions; however, both E12 and E13 epithelia elongated in response to FGF10.	lysophosphatidic acid	77-80	fibroblast growth factor 10	Mus musculus	283-288
18535112-5	2008	The ERalpha agonist, propylpyrazoletriol, did not induce regrowth by itself, but exposure to propylpyrazoletriol on d 3-5 of testosterone replacement resulted in cyclin D1-positive cells in the ductal epithelium, invasion of FGF10-positive immune cells in the regrowing prostate, and budding 14 d later.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	93-112	fibroblast growth factor 10	Mus musculus	225-230
19407009-5	2009	RESULTS: Within an ongoing ethyl-nitrosourea mutagenesis screen with C3HeB/FeJ mice, the authors identified a new mutant (referred to as Aey17) showing a slit-eye phenotype in heterozygotes; homozygous mutants are not viable because of major developmental defects.	Ethylnitrosourea	27-44	fibroblast growth factor 10	Mus musculus	137-142
19115389-8	2009	We propose that distal SP-C expressing lung epithelial cells provide essential signals for the downregulation of Fgf-10 expression in the distal mesenchyme during lung development.	sp-c	23-27	fibroblast growth factor 10	Mus musculus	113-119
19238727-6	2008	In mesenchyme-free SMG epithelium cultured with EGF, FGF7 and FGF10, U0126 (MEK inhibitor) completely blocked cleft formation, whereas U73122 (PLCgamma1 inhibitor) suppressed stalk elongation.	U 0126	69-74	fibroblast growth factor 10	Mus musculus	62-67
18677599-4	2008	17 beta-estradiol increased the expression of FGF10; progesterone and prolactin reduced the expression of FGF10 significantly in virgin; prolactin significantly increased the expression of FGF10 in pregnancy.	Estradiol	3-17	fibroblast growth factor 10	Mus musculus	46-51
18230614-1	2008	FGF10, a heparan sulfate (HS)-binding growth factor, is required for branching morphogenesis of mouse submandibular glands (SMGs).	Heparitin Sulfate	9-24	fibroblast growth factor 10	Mus musculus	0-5
18230614-1	2008	FGF10, a heparan sulfate (HS)-binding growth factor, is required for branching morphogenesis of mouse submandibular glands (SMGs).	Heparitin Sulfate	26-28	fibroblast growth factor 10	Mus musculus	0-5
18230614-10	2008	Collectively, these findings show that the size and sulfate patterns of HS modulate specific FGF10-mediated events, such as proliferation, duct elongation, end bud expansion, and differentiation, and provide mechanistic insight as to how the developmental localization of specific HS structures in tissues influences FGF10-mediated morphogenesis and differentiation.	Sulfates	52-59	fibroblast growth factor 10	Mus musculus	93-98
18412219-0	2008	Retinoic acid-induced inner ear teratogenesis caused by defective Fgf3/Fgf10-dependent Dlx5 signaling.	Tretinoin	0-13	fibroblast growth factor 10	Mus musculus	71-76
18412219-9	2008	Before Dlx5 downregulation, Fgf3 and Fgf10 expression is modified in the inner ear by excess RA, with the ability of exogenous Fgf3 and Fgf10 to rescue chondrogenesis and Dlx5 expression in RA-treated cultures of periotic mesenchyme containing otic epithelium supporting these fibroblast growth factors (FGFs) as intermediary genes by which RA mediates its effects.	Tretinoin	93-95	fibroblast growth factor 10	Mus musculus	37-42
18412219-9	2008	Before Dlx5 downregulation, Fgf3 and Fgf10 expression is modified in the inner ear by excess RA, with the ability of exogenous Fgf3 and Fgf10 to rescue chondrogenesis and Dlx5 expression in RA-treated cultures of periotic mesenchyme containing otic epithelium supporting these fibroblast growth factors (FGFs) as intermediary genes by which RA mediates its effects.	Tretinoin	190-192	fibroblast growth factor 10	Mus musculus	136-141
18412219-9	2008	Before Dlx5 downregulation, Fgf3 and Fgf10 expression is modified in the inner ear by excess RA, with the ability of exogenous Fgf3 and Fgf10 to rescue chondrogenesis and Dlx5 expression in RA-treated cultures of periotic mesenchyme containing otic epithelium supporting these fibroblast growth factors (FGFs) as intermediary genes by which RA mediates its effects.	Tretinoin	190-192	fibroblast growth factor 10	Mus musculus	136-141
17244022-7	2007	We also demonstrate that addition of fibroblast growth factor (FGF)-10 is able to partially prevent apoptosis and rescue exocrine differentiation and branching morphogenesis in atRA-treated cultures but not in mice lacking the FGF receptor 2-IIIb, suggesting the effects of FGF-10 are mediated through this receptor.	Tretinoin	177-181	fibroblast growth factor 10	Mus musculus	37-70
18077586-4	2008	Consistent with this, Fgf10-induced ectopic lacrimal gland budding in explant cultures is dependent upon Ndst gene dose, and epithelial deletion of Fgfr2 abolishes lacrimal gland budding, its specific modification of heparan sulfate and its phosphorylation of Shp2 (Ptpn11 - Mouse Genome Informatics).	Heparitin Sulfate	217-232	fibroblast growth factor 10	Mus musculus	22-27
17634193-9	2007	Our data support a novel mechanism of RA-Tgfbeta-Fgf10 interactions in the developing foregut, in which endogenous RA controls Tgfbeta activity in the prospective lung field to allow local expression of Fgf10 and induction of lung buds.	Tretinoin	38-40	fibroblast growth factor 10	Mus musculus	49-54
17634193-9	2007	Our data support a novel mechanism of RA-Tgfbeta-Fgf10 interactions in the developing foregut, in which endogenous RA controls Tgfbeta activity in the prospective lung field to allow local expression of Fgf10 and induction of lung buds.	Tretinoin	38-40	fibroblast growth factor 10	Mus musculus	203-208
17959718-0	2007	Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis.	Heparitin Sulfate	32-47	fibroblast growth factor 10	Mus musculus	58-63
17959718-2	2007	Heparan sulfate (HS) regulates the activity of FGFs by acting as a coreceptor at the cell surface, enhancing FGF-FGFR affinity, and being a storage reservoir for FGFs in the extracellular matrix (ECM).	Heparitin Sulfate	0-15	fibroblast growth factor 10	Mus musculus	47-50
17959718-2	2007	Heparan sulfate (HS) regulates the activity of FGFs by acting as a coreceptor at the cell surface, enhancing FGF-FGFR affinity, and being a storage reservoir for FGFs in the extracellular matrix (ECM).	Heparitin Sulfate	17-19	fibroblast growth factor 10	Mus musculus	47-50
17244022-7	2007	We also demonstrate that addition of fibroblast growth factor (FGF)-10 is able to partially prevent apoptosis and rescue exocrine differentiation and branching morphogenesis in atRA-treated cultures but not in mice lacking the FGF receptor 2-IIIb, suggesting the effects of FGF-10 are mediated through this receptor.	Tretinoin	177-181	fibroblast growth factor 10	Mus musculus	274-280
16806149-9	2006	Explant culture of RALDH2-deficient foreguts show a capacity to undergo lung budding and early branching in the presence of RA or FGF10.	Tretinoin	19-21	fibroblast growth factor 10	Mus musculus	130-135
11404268-0	2001	Novel mechanisms in murine nitrofen-induced pulmonary hypoplasia: FGF-10 rescue in culture.	nitrofen	27-35	fibroblast growth factor 10	Mus musculus	66-72
12508227-3	2003	By using antisense oligonucleotides (AS ODNs) and in vitro culture of embryonic lungs, we demonstrate that the transcription factors Tbx4 and Tbx5 are critical for the expression of mesenchymal FGF10.	Oligonucleotides	19-35	fibroblast growth factor 10	Mus musculus	194-199
12225946-4	2002	Herein, we demonstrate that FGF10 stimulation of mouse lung epithelial cells (MLE15) overexpressing mSpry2 results in both mSpry2 tyrosine phosphorylation and differential binding of mSpry2 to several key upstream target proteins in the MAP kinase-activating pathway.	Tyrosine	130-138	fibroblast growth factor 10	Mus musculus	28-33
11404268-1	2001	We evaluated the role of the key pulmonary morphogenetic gene fibroblast growth factor-10 (Fgf10) in murine nitrofen-induced primary lung hypoplasia, which is evident before the time of diaphragm closure.	nitrofen	108-116	fibroblast growth factor 10	Mus musculus	62-89
11404268-1	2001	We evaluated the role of the key pulmonary morphogenetic gene fibroblast growth factor-10 (Fgf10) in murine nitrofen-induced primary lung hypoplasia, which is evident before the time of diaphragm closure.	nitrofen	108-116	fibroblast growth factor 10	Mus musculus	91-96
11404268-2	2001	In situ hybridization and competitive RT-PCR revealed a profound disturbance in the temporospatial pattern as well as a 10-fold decrease in mRNA expression level of Fgf10 but not of the inducible inhibitor murine Sprouty2 (mSpry2) after nitrofen treatment.	nitrofen	237-245	fibroblast growth factor 10	Mus musculus	165-170
11404268-3	2001	Exogenous FGF-10 increased branching not only of control lungs [13% (right) and 27% (left); P < 0.01] but also of nitrofen-exposed lungs [23% (right) and 77% (left); P < 0.01].	nitrofen	117-125	fibroblast growth factor 10	Mus musculus	10-16
11404268-5	2001	We conclude that nitrofen inhibits Fgf10 expression, which is essential for lung growth and branching.	nitrofen	17-25	fibroblast growth factor 10	Mus musculus	35-40
11404268-6	2001	Exogenous FGF-10 not only stimulates FGF signaling, marked by increased mSpry2 expression, in both nitrofen-treated and control lungs but also substantially rescues nitrofen-induced lung hypoplasia in culture.	nitrofen	99-107	fibroblast growth factor 10	Mus musculus	10-16
11404268-6	2001	Exogenous FGF-10 not only stimulates FGF signaling, marked by increased mSpry2 expression, in both nitrofen-treated and control lungs but also substantially rescues nitrofen-induced lung hypoplasia in culture.	nitrofen	99-107	fibroblast growth factor 10	Mus musculus	10-13
11404268-6	2001	Exogenous FGF-10 not only stimulates FGF signaling, marked by increased mSpry2 expression, in both nitrofen-treated and control lungs but also substantially rescues nitrofen-induced lung hypoplasia in culture.	nitrofen	165-173	fibroblast growth factor 10	Mus musculus	10-16
11404268-6	2001	Exogenous FGF-10 not only stimulates FGF signaling, marked by increased mSpry2 expression, in both nitrofen-treated and control lungs but also substantially rescues nitrofen-induced lung hypoplasia in culture.	nitrofen	165-173	fibroblast growth factor 10	Mus musculus	10-13
11287183-9	2001	Conversely, Fgf10 antisense oligonucleotides reduced branching and decreased mSpry2 mRNA levels.	Oligonucleotides	28-44	fibroblast growth factor 10	Mus musculus	12-17
11238011-1	2001	Transgenic mice in which fibroblast growth factor (FGF)-10 was expressed in the lungs of fetal and postnatal mice were generated with a doxycycline-inducible system controlled by surfactant protein (SP) C or Clara cell secretory protein (CCSP) promoter elements.	Doxycycline	136-147	fibroblast growth factor 10	Mus musculus	25-58
9393979-6	1997	Upon addition of heparin, mFGF-10 protein was released into the media.	Heparin	17-24	fibroblast growth factor 10	Mus musculus	26-33
10381813-0	1999	Efficacy of keratinocyte growth factor-2 in dextran sulfate sodium-induced murine colitis.	Dextran Sulfate	44-66	fibroblast growth factor 10	Mus musculus	12-40
10381813-2	1999	Initial evaluation of KGF-2 was based on its ability to reduce weight loss, stool score, and histological score in mice exposed to DSS for 7 days.	Dextran Sulfate	131-134	fibroblast growth factor 10	Mus musculus	22-27
10381813-5	1999	When KGF-2 was given therapeutically, starting 4 days after initiation of the 7-day DSS treatment, the 3- but not the 0.5-mg/kg dose significantly enhanced weight recovery after discontinuation of DSS treatment.	Dextran Sulfate	84-87	fibroblast growth factor 10	Mus musculus	5-10
10381813-5	1999	When KGF-2 was given therapeutically, starting 4 days after initiation of the 7-day DSS treatment, the 3- but not the 0.5-mg/kg dose significantly enhanced weight recovery after discontinuation of DSS treatment.	Dextran Sulfate	197-200	fibroblast growth factor 10	Mus musculus	5-10
33626352-3	2021	Here, we use a doxycycline-inducible tetracycline (Tet)-on mice model to control fibroblast growth factor 10 (FGF10) expression, which regulates branching and tubule formation.	Doxycycline	15-26	fibroblast growth factor 10	Mus musculus	81-108
32808060-0	2021	Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice.	Betaine	0-7	fibroblast growth factor 10	Mus musculus	64-69
32808060-9	2021	Betaine treatment significantly upregulated AMP-activated protein kinase (AMPK), fibroblast growth factor 10 (FGF10), and adipose triglyceride lipase (ATGL) protein levels both in vivo and in vitro and suppressed lipid metabolism-related genes.	Betaine	0-7	fibroblast growth factor 10	Mus musculus	81-108
32808060-9	2021	Betaine treatment significantly upregulated AMP-activated protein kinase (AMPK), fibroblast growth factor 10 (FGF10), and adipose triglyceride lipase (ATGL) protein levels both in vivo and in vitro and suppressed lipid metabolism-related genes.	Betaine	0-7	fibroblast growth factor 10	Mus musculus	110-115
32808060-11	2021	CONCLUSION: Taken together, the data strongly suggest that betaine significantly prevents high-fat diet-induced NAFLD through the FGF10/AMPK signaling pathway in ApoE-/- mice.	Betaine	59-66	fibroblast growth factor 10	Mus musculus	130-135
35417692-2	2022	Using a single-cell RNA sequencing (RNA-seq) atlas of salivary gland (SG) and a tamoxifen inducible Fgf10CreERT2:R26-tdTomato mouse, we show that FGF10pos cells are exclusively mesenchymal until postnatal day 5 (P5) but, after P7, there is a switch in expression and only epithelial FGF10pos cells are observed after P15.	Tamoxifen	80-89	fibroblast growth factor 10	Mus musculus	146-151
33626352-3	2021	Here, we use a doxycycline-inducible tetracycline (Tet)-on mice model to control fibroblast growth factor 10 (FGF10) expression, which regulates branching and tubule formation.	Doxycycline	15-26	fibroblast growth factor 10	Mus musculus	110-115
33626352-3	2021	Here, we use a doxycycline-inducible tetracycline (Tet)-on mice model to control fibroblast growth factor 10 (FGF10) expression, which regulates branching and tubule formation.	Tetracycline	37-49	fibroblast growth factor 10	Mus musculus	81-108
33626352-3	2021	Here, we use a doxycycline-inducible tetracycline (Tet)-on mice model to control fibroblast growth factor 10 (FGF10) expression, which regulates branching and tubule formation.	Tetracycline	37-49	fibroblast growth factor 10	Mus musculus	110-115
33626352-3	2021	Here, we use a doxycycline-inducible tetracycline (Tet)-on mice model to control fibroblast growth factor 10 (FGF10) expression, which regulates branching and tubule formation.	Tetracycline	51-54	fibroblast growth factor 10	Mus musculus	81-108
33626352-3	2021	Here, we use a doxycycline-inducible tetracycline (Tet)-on mice model to control fibroblast growth factor 10 (FGF10) expression, which regulates branching and tubule formation.	Tetracycline	51-54	fibroblast growth factor 10	Mus musculus	110-115
33353178-7	2020	The transcriptome analysis of skin from the dorsal side of a mouse treated with tocopherol acetate or L-menthol versus vehicle revealed key changes in keratin, keratin-associated protein, forkhead box, sonic hedgehog, fibroblast growth factor 10, desmoglein 4, deoxyribonuclease 1-like 2, and cadherin 3, known to play roles in promoting hair growth.	alpha-Tocopherol	80-98	fibroblast growth factor 10	Mus musculus	218-245
33353178-7	2020	The transcriptome analysis of skin from the dorsal side of a mouse treated with tocopherol acetate or L-menthol versus vehicle revealed key changes in keratin, keratin-associated protein, forkhead box, sonic hedgehog, fibroblast growth factor 10, desmoglein 4, deoxyribonuclease 1-like 2, and cadherin 3, known to play roles in promoting hair growth.	Menthol	102-111	fibroblast growth factor 10	Mus musculus	218-245
33336117-0	2021	Myocardial protection by heparin-based coacervate of FGF10.	Heparin	25-32	fibroblast growth factor 10	Mus musculus	53-58
33336117-0	2021	Myocardial protection by heparin-based coacervate of FGF10.	coacervate	39-49	fibroblast growth factor 10	Mus musculus	53-58
33336117-10	2021	The downstream signaling of the FGF10 was also investigated, with the western blot results showing that FGF10 coacervate activated the p-FGFR, PI3K/Akt and ERK1/2 pathways to a more proper level than free FGF10 or heparin+FGF10.	Heparin	214-221	fibroblast growth factor 10	Mus musculus	32-37
33336117-10	2021	The downstream signaling of the FGF10 was also investigated, with the western blot results showing that FGF10 coacervate activated the p-FGFR, PI3K/Akt and ERK1/2 pathways to a more proper level than free FGF10 or heparin+FGF10.	Heparin	214-221	fibroblast growth factor 10	Mus musculus	104-109
33336117-10	2021	The downstream signaling of the FGF10 was also investigated, with the western blot results showing that FGF10 coacervate activated the p-FGFR, PI3K/Akt and ERK1/2 pathways to a more proper level than free FGF10 or heparin+FGF10.	Heparin	214-221	fibroblast growth factor 10	Mus musculus	104-109
33336117-10	2021	The downstream signaling of the FGF10 was also investigated, with the western blot results showing that FGF10 coacervate activated the p-FGFR, PI3K/Akt and ERK1/2 pathways to a more proper level than free FGF10 or heparin+FGF10.	Heparin	214-221	fibroblast growth factor 10	Mus musculus	104-109