PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23978451-4	2013	Prostaglandin E2 (PGE2) is the most pro-inflammatory ecoisanoid and one of the downstream products of two isoforms of cyclooxygenase (COX) enzymes: COX-1 and COX-2.	Dinoprostone	0-16	COX1	Gallus gallus	148-153
23707669-4	2013	Prostaglandin E2 (PGE2) is the most pro-inflammatory ecoisanoid and one of the downstream products of two isoforms of cyclooxygenase (COX) enzymes: COX-1 and COX-2.	Dinoprostone	0-16	COX1	Gallus gallus	148-153
23707669-4	2013	Prostaglandin E2 (PGE2) is the most pro-inflammatory ecoisanoid and one of the downstream products of two isoforms of cyclooxygenase (COX) enzymes: COX-1 and COX-2.	Dinoprostone	18-22	COX1	Gallus gallus	148-153
23978451-4	2013	Prostaglandin E2 (PGE2) is the most pro-inflammatory ecoisanoid and one of the downstream products of two isoforms of cyclooxygenase (COX) enzymes: COX-1 and COX-2.	Dinoprostone	18-22	COX1	Gallus gallus	148-153
17499748-6	2007	The specific prostaglandin synthase inhibitors SC560 (for COX-1) and NS398 (for COX-2) suppressed EGF-stimulated increase of the granulosa cell number.	Prostaglandins	13-26	COX1	Gallus gallus	58-63
23089186-2	2012	Prostaglandin E2 (PGE2) is the most pro-inflammatory lipid and one of the downstream products of 2 isoforms of cyclooxygenase (COX) enzymes: COX-1 and COX-2.	Dinoprostone	0-16	COX1	Gallus gallus	141-146
23089186-2	2012	Prostaglandin E2 (PGE2) is the most pro-inflammatory lipid and one of the downstream products of 2 isoforms of cyclooxygenase (COX) enzymes: COX-1 and COX-2.	Dinoprostone	18-22	COX1	Gallus gallus	141-146
21839805-2	2011	In the present study we show that amounts of two of its protein subunits (cytochrome c oxidase subunit I [CO-I] and II [CO-II]) are influenced by both learning-independent and learning-dependent factors.	nadide	106-110	COX1	Gallus gallus	74-104
21839805-2	2011	In the present study we show that amounts of two of its protein subunits (cytochrome c oxidase subunit I [CO-I] and II [CO-II]) are influenced by both learning-independent and learning-dependent factors.	co-ii	120-125	COX1	Gallus gallus	74-104
18498063-13	2008	The results confirm previous findings of the high expression of COX-1 in ovarian tumors further supporting the laying hen as a model for ovarian cancer, and demonstrate for the first time the high expression of COX-1 in POF-1 which is the source of prostaglandins needed for oviposition.	Prostaglandins	249-263	COX1	Gallus gallus	64-69
18498063-13	2008	The results confirm previous findings of the high expression of COX-1 in ovarian tumors further supporting the laying hen as a model for ovarian cancer, and demonstrate for the first time the high expression of COX-1 in POF-1 which is the source of prostaglandins needed for oviposition.	Prostaglandins	249-263	COX1	Gallus gallus	211-216
17499748-6	2007	The specific prostaglandin synthase inhibitors SC560 (for COX-1) and NS398 (for COX-2) suppressed EGF-stimulated increase of the granulosa cell number.	SC 560	47-52	COX1	Gallus gallus	58-63
17499748-8	2007	Though EGF promoted the expression of both COX-1 and COX-2, the rescue experiment indicated that combined treatment of PGE(1) showed better rescuing effect on NS398 inhibition than SC560 at 10(-6)M, which implies COX-2 plays the predominant role in mediating EGF action.	Prostaglandins E	119-122	COX1	Gallus gallus	43-48
16797680-4	2006	Quantitative real-time PCR with Sybr Green was used to quantify the mRNA expression of COX-1 and COX-2, using 18S expression as an internal control for COX normalization.	sybr green	32-42	COX1	Gallus gallus	87-92
14513718-9	2003	Considering that the induction of COX 1 and COX2 are inhibited by ketoprofen, and that these enzymes are located in the stromal compartment of the CAM, we propose that its antiangiogenic effect may occur via inhibition of the two COX isoforms.	Ketoprofen	66-76	COX1	Gallus gallus	34-39
10229670-1	1999	In mammals, the increased generation of prostaglandins (PG) during the onset of inflammatory responses and activation of immune cell types has been attributed to the induction of a novel cyclo-oxygenase (COX) isoform, termed COX-2, which is distinct from the well-characterized constitutive activity (COX-1).	Prostaglandins	40-54	COX1	Gallus gallus	301-306
10229670-1	1999	In mammals, the increased generation of prostaglandins (PG) during the onset of inflammatory responses and activation of immune cell types has been attributed to the induction of a novel cyclo-oxygenase (COX) isoform, termed COX-2, which is distinct from the well-characterized constitutive activity (COX-1).	Prostaglandins	56-58	COX1	Gallus gallus	301-306
34732778-4	2021	As compared to control, Fluticasone resulted in a significant decrease in the mRNA expression of COX-1 and pro-and anti-inflammatory cytokines, and increase in COX-2 mRNA expression and heterophil to lymphocyte ratio (P < 0.001).	Fluticasone	24-35	COX1	Gallus gallus	97-102
33440267-8	2021	The expressions of metabolic and stress response genes (CYP450, GST, COX1, COX2, HSP70 and MT) in hepatopancreas of crayfish were significantly up-regulated by maduramicin (7.0 mgL-1) treatment for 8 h to 7 d, and returned to normal levels after the removal of maduramicin for 3-7 days.	maduramicin	160-171	COX1	Gallus gallus	69-73
32110995-5	2020	Quercetin relieved LPS-induced jejunal mitochondria damage and upregulated mitochondrial DNA copy number-related gene expression, including cytochrome c oxidase subunit 1 (COX1), ATP synthase F0 subunit 6 (ATP6), and NADH dehydrogenase subunit 1 (ND1).	Quercetin	0-9	COX1	Gallus gallus	172-176
33454433-5	2021	The compensatory increase in the activity of COX-1 observed in the etoricoxib-treated group helped to maintain the levels of PGD2, PGF2alpha, and TXB2.	Etoricoxib	67-77	COX1	Gallus gallus	45-50
33454433-5	2021	The compensatory increase in the activity of COX-1 observed in the etoricoxib-treated group helped to maintain the levels of PGD2, PGF2alpha, and TXB2.	Dinoprost	131-140	COX1	Gallus gallus	45-50