PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28195469-4	2017	Analysis of urinary contents from rats administered with EC, A-type procyanidin dimer (A-2), and A-type procyanidin trimer (A-3) showed distinct native and metabolite profiles for each rat.	procyanidin	104-115	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	124-127
30104323-9	2018	Together, our results demonstrate that increased levels of succinate in settings of metabolic stress (e.g., the metabolic syndrome) may lead to impaired mirabegron and beta3-AR interaction, inhibition of cAMP production, and ultimately requiring mirabegron dose adjustment for its treatment of OAB related to these conditions.	Succinic Acid	59-68	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	168-173
30009768-0	2018	Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation.	Resveratrol	0-11	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	75-81
30009768-4	2018	UDP-glucuronosyltransferase 1A8 (UGT1A8) is an important phase II drug-metabolizing enzymes which involved in the metabolism of catechol estrogens.	catechol	128-136	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-31
30009768-4	2018	UDP-glucuronosyltransferase 1A8 (UGT1A8) is an important phase II drug-metabolizing enzymes which involved in the metabolism of catechol estrogens.	catechol	128-136	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	33-39
30009768-5	2018	Here we found that the mammary nuclear factor erythroid 2-related factor 2 (NRF2) - UGT1A8 signaling was down-regulated in breast cancer rats, whereas treatment with resveratrol could upregulate the expression of NRF2 and UGT1A8, accelerate metabolic elimination of catechol estrogens, inhibit estrogen-induced DNA damage and suppress the pathological development of breast cancer.	Resveratrol	166-177	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	84-90
30009768-5	2018	Here we found that the mammary nuclear factor erythroid 2-related factor 2 (NRF2) - UGT1A8 signaling was down-regulated in breast cancer rats, whereas treatment with resveratrol could upregulate the expression of NRF2 and UGT1A8, accelerate metabolic elimination of catechol estrogens, inhibit estrogen-induced DNA damage and suppress the pathological development of breast cancer.	Resveratrol	166-177	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	222-228
30009768-5	2018	Here we found that the mammary nuclear factor erythroid 2-related factor 2 (NRF2) - UGT1A8 signaling was down-regulated in breast cancer rats, whereas treatment with resveratrol could upregulate the expression of NRF2 and UGT1A8, accelerate metabolic elimination of catechol estrogens, inhibit estrogen-induced DNA damage and suppress the pathological development of breast cancer.	catechol	266-274	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	84-90
30009768-6	2018	In addition, luciferase reporter assay suggested that resveratrol activated the expression of UGT1A8 by up-regulating the transcriptional activity of NRF2.	Resveratrol	54-65	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	94-100
30009768-7	2018	Small-interfering RNA-mediated silencing of NRF2 abolished resveratrol-mediated preventive effects indicated that the antitumor effect of resveratrol is based on NRF2-UGT1A8-estrogen metabolism axis.	Resveratrol	59-70	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	167-173
30009768-7	2018	Small-interfering RNA-mediated silencing of NRF2 abolished resveratrol-mediated preventive effects indicated that the antitumor effect of resveratrol is based on NRF2-UGT1A8-estrogen metabolism axis.	Resveratrol	138-149	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	167-173
30009768-8	2018	Taken together, we established the resveratrol regulating potential on estrogen homeostasis based on NRF2-UGT1A8 signaling pathway, and also provided a novel link between estrogen glucuronidation metabolism and breast cancer pathological development.	Resveratrol	35-46	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	106-112
28633128-6	2017	KEY FINDINGS: One monoglucuronide was detected in reactions catalyzed by rUGT1A6, rUGT1A8, rUGT1A9, also human and dog liver microsomes.	monoglucuronide	18-33	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	82-89
28195469-5	2017	Rats fed with A-2 and A-3 presented significantly higher levels of shikimic acid and less amount of m(p)-coumaric acid metabolites in vivo and provide insight into the quantitative structure-activity relationship of procyanidin oligomers during metabolism, indicating that procyanidins with A-type linkage could induce an altered metabolic pathway of oligomers in the gastrointestinal system.	Shikimic Acid	67-80	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	22-25
28195469-5	2017	Rats fed with A-2 and A-3 presented significantly higher levels of shikimic acid and less amount of m(p)-coumaric acid metabolites in vivo and provide insight into the quantitative structure-activity relationship of procyanidin oligomers during metabolism, indicating that procyanidins with A-type linkage could induce an altered metabolic pathway of oligomers in the gastrointestinal system.	Coumaric Acids	105-118	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	22-25
28195469-5	2017	Rats fed with A-2 and A-3 presented significantly higher levels of shikimic acid and less amount of m(p)-coumaric acid metabolites in vivo and provide insight into the quantitative structure-activity relationship of procyanidin oligomers during metabolism, indicating that procyanidins with A-type linkage could induce an altered metabolic pathway of oligomers in the gastrointestinal system.	procyanidin	216-227	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	22-25
28195469-5	2017	Rats fed with A-2 and A-3 presented significantly higher levels of shikimic acid and less amount of m(p)-coumaric acid metabolites in vivo and provide insight into the quantitative structure-activity relationship of procyanidin oligomers during metabolism, indicating that procyanidins with A-type linkage could induce an altered metabolic pathway of oligomers in the gastrointestinal system.	Proanthocyanidins	273-285	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	22-25
27002404-11	2016	Multiple UGTs, including UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10, were involved in forming WEL glucuronides and O-methylated WEL glucuronides.	wel glucuronides	111-127	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	57-63
23523942-11	2013	The mRNA levels from UGT1A8 and UGT1A2 were decreased by stilbene glucoside treatment.	2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside	57-75	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	21-27
25766133-8	2015	The protein expression of beta3-ARs was notably upregulated, but 5-HT4 receptors were significantly decreased in the colonic muscularis externa of 6-OHDA rats.	Oxidopamine	147-153	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	26-31
25766133-9	2015	We conclude that enhanced DA and beta3-ARs and decreased 5-HT4 receptors may be contributed to the colonic dysmotility and constipation observed in 6-OHDA rats.	Oxidopamine	148-154	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	33-38
24261979-8	2013	GA was identified to be the active component of the aqueous extract of licorice responsible for induction of UGT1A8 in the rat liver.	18alpha-glycyrrhetinic acid	0-2	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	109-115
23562886-2	2013	Previous studies have indicated that danshensu (beta-3,4-dihydroxyphenyl-lactic acid), a main hydrophilic component of the Chinese materia medica Radix Salviae Miltiorrhizae (Danshen, Pharmacopoeia of PR China), has ROS scavenging and antioxidant activities, however its mechanism of action was not clear.	Reactive Oxygen Species	216-219	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	48-56
23523942-13	2013	CONCLUSIONS: The influence of stilbene glucoside on the pharmacokinetics of emodin may be attributed to the inhibition of UGT1A8 mRNA expression.	2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside	30-48	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	122-128
15955596-5	2005	The alpha4, alpha7, beta2 and beta3 subunits and related calcium channel responses were found in these cells, whereas neither alpha2 nor alpha3 could be detected.	Calcium	57-64	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	30-35
15502008-7	2005	UGT1A8 was most active toward the 1-OH, 4-OH, 5-OH, 6-OH, 7-OH, 10-OH, 11-OH, and 12-OH derivatives of benzo[a]pyrene.	2-nitrophenol	34-38	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-6
15502008-7	2005	UGT1A8 was most active toward the 1-OH, 4-OH, 5-OH, 6-OH, 7-OH, 10-OH, 11-OH, and 12-OH derivatives of benzo[a]pyrene.	4-oh	40-44	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-6
15502008-7	2005	UGT1A8 was most active toward the 1-OH, 4-OH, 5-OH, 6-OH, 7-OH, 10-OH, 11-OH, and 12-OH derivatives of benzo[a]pyrene.	5-oh	46-50	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-6
15502008-7	2005	UGT1A8 was most active toward the 1-OH, 4-OH, 5-OH, 6-OH, 7-OH, 10-OH, 11-OH, and 12-OH derivatives of benzo[a]pyrene.	6-oh	52-56	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-6
15502008-7	2005	UGT1A8 was most active toward the 1-OH, 4-OH, 5-OH, 6-OH, 7-OH, 10-OH, 11-OH, and 12-OH derivatives of benzo[a]pyrene.	7-oh	58-62	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-6
15502008-7	2005	UGT1A8 was most active toward the 1-OH, 4-OH, 5-OH, 6-OH, 7-OH, 10-OH, 11-OH, and 12-OH derivatives of benzo[a]pyrene.	10-oh	64-69	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-6
15502008-7	2005	UGT1A8 was most active toward the 1-OH, 4-OH, 5-OH, 6-OH, 7-OH, 10-OH, 11-OH, and 12-OH derivatives of benzo[a]pyrene.	11-oh	71-76	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-6
15502008-7	2005	UGT1A8 was most active toward the 1-OH, 4-OH, 5-OH, 6-OH, 7-OH, 10-OH, 11-OH, and 12-OH derivatives of benzo[a]pyrene.	12-oh	82-87	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-6
15502008-7	2005	UGT1A8 was most active toward the 1-OH, 4-OH, 5-OH, 6-OH, 7-OH, 10-OH, 11-OH, and 12-OH derivatives of benzo[a]pyrene.	Benzo(a)pyrene	103-117	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-6
15502008-8	2005	Other effective UGT1A8 substrates (>0.1 nmol/mg/min) included 9-OH-benzo[a]pyrene, 1-naphthol, 4-methylumbelliferone, 7-hydroxycoumarin, chrysin, quercetin, 4-nitrophenol, and estriol.	chrysin	140-147	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	16-22
15502008-8	2005	Other effective UGT1A8 substrates (>0.1 nmol/mg/min) included 9-OH-benzo[a]pyrene, 1-naphthol, 4-methylumbelliferone, 7-hydroxycoumarin, chrysin, quercetin, 4-nitrophenol, and estriol.	Quercetin	149-158	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	16-22
15502008-8	2005	Other effective UGT1A8 substrates (>0.1 nmol/mg/min) included 9-OH-benzo[a]pyrene, 1-naphthol, 4-methylumbelliferone, 7-hydroxycoumarin, chrysin, quercetin, 4-nitrophenol, and estriol.	4-nitrophenol	160-173	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	16-22
15502008-8	2005	Other effective UGT1A8 substrates (>0.1 nmol/mg/min) included 9-OH-benzo[a]pyrene, 1-naphthol, 4-methylumbelliferone, 7-hydroxycoumarin, chrysin, quercetin, 4-nitrophenol, and estriol.	Estriol	179-186	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	16-22
15502008-9	2005	In general, substrates preferred by UGT1A8 were polyaromatic planar structures with nonbulky substituents and a superimposable 1-naphtho ring structure.	1-naphtho	127-136	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	36-42
12816318-1	2003	Halofantrine hydrochloride (halfan) was administered via oral route to matured female wistar rats weighing 180-200 g. The Wistar rats were randomly selected and divided into six groups of four rats each, making a total of twenty four rats and coded A1, A2, A3, B1, B2 and B3.	halofantrine	0-26	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	257-274
33506492-10	2021	The beta3 -AR antagonist L748,337 (1 muM) inhibited vasodilation caused by beta3 -AR agonists (in the presence of beta1/2 -AR blockade), but L748,337 had no effect on isoprenaline-induced vasodilation.	1-(4-Methyl-3-nitrophenyl)ethanone	25-29	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	4-9
11746374-5	2001	Significant reductions in [(125)I]alpha-bungarotoxin binding site, protein level for the alpha3 and alpha7 subunits, and mRNA level for the alpha7 subunit were observed in PC12 cells treated by FeSO(4) at the concentrations without inducing cell death compared to control.	feso(4)	194-201	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	89-106
32865327-0	2021	Increased energy expenditure and activated beta3-AR-cAMP-PKA signaling pathway in the interscapular brown adipose tissue of 6-OHDA-induced Parkinson"s disease model rats.	Cyclic AMP	52-56	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	43-48
32865327-0	2021	Increased energy expenditure and activated beta3-AR-cAMP-PKA signaling pathway in the interscapular brown adipose tissue of 6-OHDA-induced Parkinson"s disease model rats.	Oxidopamine	124-130	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	43-48
32865327-9	2021	CONCLUSION: The present study suggested an increased energy expenditure and activation of beta3-AR-cAMP-PKA signaling pathway in the IBAT after the destruction of dopamine system in the SN of rat.	Cyclic AMP	99-103	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	90-95
32865327-9	2021	CONCLUSION: The present study suggested an increased energy expenditure and activation of beta3-AR-cAMP-PKA signaling pathway in the IBAT after the destruction of dopamine system in the SN of rat.	Dopamine	163-171	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	90-95
11992647-0	2002	Induction of UDP-glucuronosyltransferase 1A8 mRNA by 3-methylcholanthene in rat hepatoma cells.	3-methylcholanthene	53-72	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	13-44
11992647-5	2002	The induction effect of 3-MC led to the expression of UGT1A8 which has not been reported before.	Methylcholanthrene	24-28	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	54-60
11992647-7	2002	Northern blot analysis showed a 4-fold increase in UGT1A8 transcription after treatment with 3-MC.	Methylcholanthrene	93-97	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	51-57
11992647-10	2002	Transcriptional activation of the UGT1A8 by 3-MC does not appear to require de novo protein synthesis.	Methylcholanthrene	44-48	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	34-40
33773180-6	2021	The macromolecule DEHP-BSA cannot pass through the cell membrane to interact with nuclear receptors but upregulated the c-fos gene expression when administered at concentrations comparable to DEHP concentrations; molecular docking demonstrated that DEHP has affinity for the membrane receptor integrin alphavbeta3; DEHP at 2 mumol/L upregulated the beta3 gene expression in GH3 cells; after the addition of integrin alphavbeta3-inhibiting RGD peptide, DEHP-induced c-fos gene upregulation decreased.	Diethylhexyl Phthalate	18-22	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	308-313
34157371-2	2021	Recently, SR58611A, a brain-penetrant beta3-AR agonist, exhibits anxiolytic- and antidepressant-like effects.	amibegron	10-18	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	38-43
33506492-10	2021	The beta3 -AR antagonist L748,337 (1 muM) inhibited vasodilation caused by beta3 -AR agonists (in the presence of beta1/2 -AR blockade), but L748,337 had no effect on isoprenaline-induced vasodilation.	1-(4-Methyl-3-nitrophenyl)ethanone	25-29	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	75-80
33506492-10	2021	The beta3 -AR antagonist L748,337 (1 muM) inhibited vasodilation caused by beta3 -AR agonists (in the presence of beta1/2 -AR blockade), but L748,337 had no effect on isoprenaline-induced vasodilation.	Isoproterenol	167-179	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	4-9
32503411-17	2020	CONCLUSION: The beta3-AR agonist BRL37344 is beneficial for reducing liver fat accumulation and for ameliorating liver steatosis and inflammation in NAFLD.	BRL 37344	33-41	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	16-21
33380469-0	2021	alpha3* Nicotinic acetylcholine receptors in the habenula-interpeduncular nucleus circuit regulate nicotine intake.	Acetylcholine	18-31	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-7
33380469-0	2021	alpha3* Nicotinic acetylcholine receptors in the habenula-interpeduncular nucleus circuit regulate nicotine intake.	Nicotine	99-107	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-7
33314348-12	2021	beta3 -AR mRNA increase was partly limited by nebivolol.	Nebivolol	46-55	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	0-5
32034680-7	2020	Chromium-induced myometrial relaxation was also significantly (P < 0.05) reduced in the presence of ICI 118,551 (a selective beta2-antagonist) and SR 59230A (a selective beta3-antagonist).	Chromium	0-8	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	173-178
32034680-7	2020	Chromium-induced myometrial relaxation was also significantly (P < 0.05) reduced in the presence of ICI 118,551 (a selective beta2-antagonist) and SR 59230A (a selective beta3-antagonist).	3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate	150-159	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	173-178
33288547-7	2021	Either alpha3 or gamma1 subunit silencing by siRNA transfection changed the GABA-response characteristics in oligodendrocyte precursor cells, indicating their participation in the endogenous receptor conformation.	gamma-Aminobutyric Acid	76-80	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	7-13
32228862-3	2020	Here, we used a Forster Resonance Energy Transfer (FRET)-based cGMP biosensor combined with scanning ion conductance microscopy (SICM) to show that functional beta3-ARs are mostly confined to the T-tubules of healthy rat cardiomyocytes.	Cyclic GMP	63-67	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	159-164
31820090-6	2020	Using an isolated cardiomyocyte model, we found inotropic and chronotropic effects, and increased calcium transient [Ca2+]i in cells treated with ADO receptor A1 or A3 antagonists compared to control groups.	Calcium	98-105	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	150-167
31820090-6	2020	Using an isolated cardiomyocyte model, we found inotropic and chronotropic effects, and increased calcium transient [Ca2+]i in cells treated with ADO receptor A1 or A3 antagonists compared to control groups.	Calcium	117-121	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	150-167
31820090-6	2020	Using an isolated cardiomyocyte model, we found inotropic and chronotropic effects, and increased calcium transient [Ca2+]i in cells treated with ADO receptor A1 or A3 antagonists compared to control groups.	Adenosine	146-149	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	150-167
31820090-7	2020	Upon co-treatment with MRAs, EPL and SPI fully and partially reverted the effects of receptor A1 or A3 antagonism, respectively.	epl	29-32	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	85-102
31820090-7	2020	Upon co-treatment with MRAs, EPL and SPI fully and partially reverted the effects of receptor A1 or A3 antagonism, respectively.	Spironolactone	37-40	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	85-102
32030913-5	2020	Rats were pretreated with either a combination of the muscarinic antagonist tolterodine and beta3 -selective adrenoceptor agonist mirabegron or saline for 10 days.	mirabegron	130-140	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	92-97
31325431-12	2019	Both females and males displayed an increase in beta3 and beta4 during nicotine withdrawal.	Nicotine	71-79	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	48-53
31596949-1	2020	BACKGROUND AND PURPOSE: Adenosine is a local mediator that regulates physiological and pathological processes via activation of four G protein-coupled receptors (A1 , A2A , A2B , A3 ).	Adenosine	24-33	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	173-181
30613975-2	2019	Therefore, we examined the molecular mechanism of beta3 -AR activation in depressed myocardial contractility using a specific agonist CL316243 or using beta3 -AR overexpressed cardiomyocytes.	disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate	134-142	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	50-55
30613975-4	2019	Furthermore, the increased [Zn2+ ]i induced a significant increase in messenger RNA (mRNA) level of beta3 -AR in cardiomyocytes.	Zinc	28-32	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	100-105
30613975-5	2019	Either beta3 -AR activation or its overexpression could increase cellular reactive oxygen species (ROS) and reactive nitrogen species (RNS) levels, in line with significant changes in nitric oxide (NO)-pathway, including increases in the ratios of pNOS3/NOS3 and pGSK-3beta/GSK-3beta, and PKG expression level in cardiomyocytes.	Reactive Oxygen Species	74-97	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	7-12
30613975-5	2019	Either beta3 -AR activation or its overexpression could increase cellular reactive oxygen species (ROS) and reactive nitrogen species (RNS) levels, in line with significant changes in nitric oxide (NO)-pathway, including increases in the ratios of pNOS3/NOS3 and pGSK-3beta/GSK-3beta, and PKG expression level in cardiomyocytes.	Reactive Oxygen Species	99-102	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	7-12
30613975-5	2019	Either beta3 -AR activation or its overexpression could increase cellular reactive oxygen species (ROS) and reactive nitrogen species (RNS) levels, in line with significant changes in nitric oxide (NO)-pathway, including increases in the ratios of pNOS3/NOS3 and pGSK-3beta/GSK-3beta, and PKG expression level in cardiomyocytes.	Nitrogen	117-125	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	7-12
30613975-5	2019	Either beta3 -AR activation or its overexpression could increase cellular reactive oxygen species (ROS) and reactive nitrogen species (RNS) levels, in line with significant changes in nitric oxide (NO)-pathway, including increases in the ratios of pNOS3/NOS3 and pGSK-3beta/GSK-3beta, and PKG expression level in cardiomyocytes.	Reactive Nitrogen Species	135-138	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	7-12
30613975-5	2019	Either beta3 -AR activation or its overexpression could increase cellular reactive oxygen species (ROS) and reactive nitrogen species (RNS) levels, in line with significant changes in nitric oxide (NO)-pathway, including increases in the ratios of pNOS3/NOS3 and pGSK-3beta/GSK-3beta, and PKG expression level in cardiomyocytes.	Nitric Oxide	184-196	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	7-12
30613975-9	2019	Overall, our present data can emphasize the important deleterious effect of beta3 -AR activation in cardiac remodeling under pathological condition, at least, through a cross-link between beta3 -AR activation, NO-signaling, and [Zn2+ ]i pathways.	Zinc	229-233	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	76-81
31150459-2	2019	Adenosine can activate four subtypes of adenosine receptors (A1, A2A, A2B and A3) and has been implicated in diabetic nephropathy.	Adenosine	0-9	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	70-80
31150459-2	2019	Adenosine can activate four subtypes of adenosine receptors (A1, A2A, A2B and A3) and has been implicated in diabetic nephropathy.	Adenosine	40-49	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	70-80
32149269-9	2019	Next, exposing NRK cells to different concentrations of peroxynitrite provided evidence that the higher levels of peroxynitrite exposure decreased the key subunits (beta5 and alpha3) of the proteasome in NRK cells.	Peroxynitrous Acid	56-69	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	175-181
32149269-9	2019	Next, exposing NRK cells to different concentrations of peroxynitrite provided evidence that the higher levels of peroxynitrite exposure decreased the key subunits (beta5 and alpha3) of the proteasome in NRK cells.	Peroxynitrous Acid	114-127	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	175-181