PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
3112407-1	1987	Sodium-calcium exchange has been suggested to play a pivotal role in the regulation of cytosolic free calcium (Caf) by epithelial cells.	Sodium	0-6	lysine acetyltransferase 2B	Homo sapiens	111-114
3667022-8	1987	The plasma free fatty acid (FFA) level was higher in Caf than in Con.	Fatty Acids, Nonesterified	11-26	lysine acetyltransferase 2B	Homo sapiens	53-56
3667022-8	1987	The plasma free fatty acid (FFA) level was higher in Caf than in Con.	Fatty Acids, Nonesterified	28-31	lysine acetyltransferase 2B	Homo sapiens	53-56
3667022-9	1987	The plasma glucose and lactic acid concentrations were highest in Su + Caf while the plasma FFA level was the same as in Con.	Glucose	11-18	lysine acetyltransferase 2B	Homo sapiens	71-74
3667022-9	1987	The plasma glucose and lactic acid concentrations were highest in Su + Caf while the plasma FFA level was the same as in Con.	Lactic Acid	23-34	lysine acetyltransferase 2B	Homo sapiens	71-74
2464358-5	1988	The DBCG trial 80-R2 is the largest randomized trial of CAF (cyclophosphamide, doxorubicin, 5-fluorouracil) versus CMF (cyclophosphamide, methotrexate, 5-fluorouracil) in recurrent breast cancer.	dbcg	4-8	lysine acetyltransferase 2B	Homo sapiens	56-59
2464358-5	1988	The DBCG trial 80-R2 is the largest randomized trial of CAF (cyclophosphamide, doxorubicin, 5-fluorouracil) versus CMF (cyclophosphamide, methotrexate, 5-fluorouracil) in recurrent breast cancer.	Cyclophosphamide	61-77	lysine acetyltransferase 2B	Homo sapiens	56-59
3431374-4	1987	Blood free fatty acids rose (P less than 0.05) further for CON (1,336), CAF (1,126), and FRU (1,034) over CFG (737) and GLU (714 mumol.l-1).	Fatty Acids, Nonesterified	6-22	lysine acetyltransferase 2B	Homo sapiens	72-75
3431374-5	1987	Muscle glycogen utilization was greater (P less than 0.05) for CON (91) vs CAF (63) and GLU (62 mumol/g-1 wet muscle weight).	Glycogen	7-15	lysine acetyltransferase 2B	Homo sapiens	75-78
3431374-6	1987	It was concluded that GLU and CAF decrease muscle glycogen utilization, FRU is likely to cause gastric upset, and ingestion of multiple substances produces the greatest variability in muscle glycogen utilization and may provide added endurance benefits in some individuals.	Glycogen	50-58	lysine acetyltransferase 2B	Homo sapiens	30-33
3496921-2	1987	Explicit properties are first assigned to all relatively rapidly equilibrating calcium binding sites in the myoplasm so that the calcium content (CaF) in this pool of "fast" calcium can be calculated from the calcium transient.	Calcium	79-86	lysine acetyltransferase 2B	Homo sapiens	146-149
3496921-2	1987	Explicit properties are first assigned to all relatively rapidly equilibrating calcium binding sites in the myoplasm so that the calcium content (CaF) in this pool of "fast" calcium can be calculated from the calcium transient.	Calcium	129-136	lysine acetyltransferase 2B	Homo sapiens	146-149
3496921-2	1987	Explicit properties are first assigned to all relatively rapidly equilibrating calcium binding sites in the myoplasm so that the calcium content (CaF) in this pool of "fast" calcium can be calculated from the calcium transient.	Calcium	129-136	lysine acetyltransferase 2B	Homo sapiens	146-149
3496921-2	1987	Explicit properties are first assigned to all relatively rapidly equilibrating calcium binding sites in the myoplasm so that the calcium content (CaF) in this pool of "fast" calcium can be calculated from the calcium transient.	Calcium	129-136	lysine acetyltransferase 2B	Homo sapiens	146-149
3496921-3	1987	The overall properties of the transport systems and relatively slowly equilibrating binding sites that remove calcium from CaF are then characterized experimentally from the decay of CaF following fiber repolarization.	Calcium	110-117	lysine acetyltransferase 2B	Homo sapiens	123-126
3496921-4	1987	The rate of calcium release can then be calculated as dCaF/dt plus the rate of removal of calcium from CaF.	Calcium	12-19	lysine acetyltransferase 2B	Homo sapiens	55-58
3496921-9	1987	The calculated release wave form will be accurate provided that the properties assumed for CaF are correct, that release turns off within a relatively short time after fiber repolarization, that the properties of the slow removal system are the same during and after fiber depolarization, and that possible spatial nonuniformities of free or bound calcium do not introduce major errors.	Calcium	348-355	lysine acetyltransferase 2B	Homo sapiens	91-94
3112407-1	1987	Sodium-calcium exchange has been suggested to play a pivotal role in the regulation of cytosolic free calcium (Caf) by epithelial cells.	Calcium	7-14	lysine acetyltransferase 2B	Homo sapiens	111-114
3112407-1	1987	Sodium-calcium exchange has been suggested to play a pivotal role in the regulation of cytosolic free calcium (Caf) by epithelial cells.	Calcium	102-109	lysine acetyltransferase 2B	Homo sapiens	111-114
3112407-2	1987	Using isolated epithelial cells from the toad urinary bladder, Caf has been measured using the intracellular Ca-sensitive fluorescent dyes Fura 2 and Quin 2.	Fura-2	139-145	lysine acetyltransferase 2B	Homo sapiens	63-66
3112407-2	1987	Using isolated epithelial cells from the toad urinary bladder, Caf has been measured using the intracellular Ca-sensitive fluorescent dyes Fura 2 and Quin 2.	Quin2	150-156	lysine acetyltransferase 2B	Homo sapiens	63-66
3112407-7	1987	While medium sodium substitution increased Caf, prolonged treatment with ouabain had no effect on Caf despite a clear increase in cell sodium content.	Sodium	13-19	lysine acetyltransferase 2B	Homo sapiens	43-46
3112407-9	1987	However, exchange-mediated Ca efflux may play a role in Caf regulation when cytosolic calcium is elevated.	Calcium	86-93	lysine acetyltransferase 2B	Homo sapiens	56-59
3887510-0	1985	[Flush induced by chlorpropamide-alcohol (CAF): a genetic marker of diabetes mellitus or an undesirable effect of the drug?	chlorpropamide-alcohol	18-40	lysine acetyltransferase 2B	Homo sapiens	42-45
2942544-7	1986	The slow ATP hydrolysis on Ca-F-actin causes a lag in the increase in fluorescence associated with the elongation of actin labeled with the fluorophore N-pyrene iodoacetamide (pyrenyl-labeled actin), even though there is no lag in the elongation rate, because pyrenyl-labeled ATP-F-actin subunits have a lower fluorescence intensity than pyrenyl-labeled ADP-F-actin subunits.	Adenosine Triphosphate	9-12	lysine acetyltransferase 2B	Homo sapiens	27-31
2942544-7	1986	The slow ATP hydrolysis on Ca-F-actin causes a lag in the increase in fluorescence associated with the elongation of actin labeled with the fluorophore N-pyrene iodoacetamide (pyrenyl-labeled actin), even though there is no lag in the elongation rate, because pyrenyl-labeled ATP-F-actin subunits have a lower fluorescence intensity than pyrenyl-labeled ADP-F-actin subunits.	n-pyrene iodoacetamide	152-174	lysine acetyltransferase 2B	Homo sapiens	27-31
3894587-7	1985	Other investigators who have compared CAF to CMF-containing regimens have reported a large advantage in CAF therapy among patients with "good risk" sites of metastases (local-regional recurrence, bone, lung nodules).	CMF regimen	45-48	lysine acetyltransferase 2B	Homo sapiens	104-107
5882024-0	1965	[On clinical experimentation with a new therapeutic combination, Caf-lysozyme-dimethylaminoisopyrazolone (Balmycin)].	balmycin	106-114	lysine acetyltransferase 2B	Homo sapiens	65-68
6683184-7	1983	Clinical trials previously performed by our group comparing cyclophosphamide alone, either vs cis-platinum, adriamycin and hexamethylmelamine or vs Hexa-CAF, showed a better remission rate with the use of moderate-dose cyclophosphamide alone.	Cyclophosphamide	219-235	lysine acetyltransferase 2B	Homo sapiens	153-156
6794922-9	1981	Nevertheless, considering the rate of CR in patients with gross disease (20.6%), HEXA-CAF combination seems a useful but not yet a hopeful treatment for patients with advanced ovarian carcinoma.	Chromium	38-40	lysine acetyltransferase 2B	Homo sapiens	86-89
6773656-0	1980	Treatment of advanced ovarian carcinoma with a combination of hexmethylmelamine, cyclophosphamide, methotrexate, and 5-fluorourcil (hexa-CAF) in patients with and without previous treatment.	5-fluorourcil	117-130	lysine acetyltransferase 2B	Homo sapiens	137-140
1276130-11	1976	Purified CAF migrated as a single band during polyacrylamide gel electrophoresis in pH 7.5 Tris-HC1 buffer but migrated as two bands with molecular weights of 80 000 and 30 000 during polyacrylamide gel electrophoresis in sodium dodecyl sulfate.	polyacrylamide	46-60	lysine acetyltransferase 2B	Homo sapiens	9-12
1276130-11	1976	Purified CAF migrated as a single band during polyacrylamide gel electrophoresis in pH 7.5 Tris-HC1 buffer but migrated as two bands with molecular weights of 80 000 and 30 000 during polyacrylamide gel electrophoresis in sodium dodecyl sulfate.	tris-hc1	91-99	lysine acetyltransferase 2B	Homo sapiens	9-12
1276130-11	1976	Purified CAF migrated as a single band during polyacrylamide gel electrophoresis in pH 7.5 Tris-HC1 buffer but migrated as two bands with molecular weights of 80 000 and 30 000 during polyacrylamide gel electrophoresis in sodium dodecyl sulfate.	polyacrylamide	184-198	lysine acetyltransferase 2B	Homo sapiens	9-12
1276130-11	1976	Purified CAF migrated as a single band during polyacrylamide gel electrophoresis in pH 7.5 Tris-HC1 buffer but migrated as two bands with molecular weights of 80 000 and 30 000 during polyacrylamide gel electrophoresis in sodium dodecyl sulfate.	Sodium Dodecyl Sulfate	222-244	lysine acetyltransferase 2B	Homo sapiens	9-12
1276130-12	1976	Densitometric scans of sodium dodecyl sulfate-polyacrylamide gels show that the 80 000- and 30 000-dalton subunits make up 85 to 90% of the protein in purified CAF preparations and that these subunits are present in equimolar ratios.	Sodium Dodecyl Sulfate	23-45	lysine acetyltransferase 2B	Homo sapiens	160-163
33705881-3	2021	Therefore, CAFs and CAF-related mechanisms have emerged as promising targets for PDAC therapy.	pdac	81-85	lysine acetyltransferase 2B	Homo sapiens	11-14
33938030-9	2021	Our results pinpoint the function of GPR30 in prostate CAFs on regulating the CAF-TAM interaction in the TME and provide new insights into PCa therapies via regulating TME.	tam	82-85	lysine acetyltransferase 2B	Homo sapiens	55-58
33999859-3	2021	OBJECTIVE: In this study, we explored the function and mechanisms of exosomal miR-103a-3p derived from cancer-associated fibroblast (CAF) in cisplatin resistance in NSCLC.	Cisplatin	141-150	lysine acetyltransferase 2B	Homo sapiens	133-136
33999859-9	2021	In vivo tumorigenesis assay showed CAF-derived exosomal miR-103a-3p enhanced cisplatin resistance and inhibited cell apoptosis in NSCLC.	mir-103a-3p	56-67	lysine acetyltransferase 2B	Homo sapiens	35-38
33999859-9	2021	In vivo tumorigenesis assay showed CAF-derived exosomal miR-103a-3p enhanced cisplatin resistance and inhibited cell apoptosis in NSCLC.	Cisplatin	77-86	lysine acetyltransferase 2B	Homo sapiens	35-38
34055630-5	2021	We show that, while carnosol does not affect HDACs, it promotes a ROS-dependent proteasome degradation of p300 and PCAF histone acetyl transferases (HATs) without affecting other HATs such as GCN5 and hMOF.	carnosol	20-28	lysine acetyltransferase 2B	Homo sapiens	115-119
34055630-5	2021	We show that, while carnosol does not affect HDACs, it promotes a ROS-dependent proteasome degradation of p300 and PCAF histone acetyl transferases (HATs) without affecting other HATs such as GCN5 and hMOF.	ros	66-69	lysine acetyltransferase 2B	Homo sapiens	115-119
34055630-6	2021	Carnosol-induced histone hypoacetylation remains persistent even when p300 and PCAF protein levels were rescued from degradation by (i) the inhibition of the proteasome activity by the proteasome inhibitors MG-132 and bortezomib, and (ii) the inhibition of ROS accumulation by the ROS scavenger, N-acetylcysteine.	carnosol	0-8	lysine acetyltransferase 2B	Homo sapiens	79-83
33720323-5	2021	In this study, we aimed to investigate the role and mechanisms of CAF-derived exosomal LINC00355 in BC cell resistance to cisplatin.	Cisplatin	122-131	lysine acetyltransferase 2B	Homo sapiens	66-69
33248168-7	2021	P300/CBP-associated factor (PCAF)-mediated acetylation of LDHB K82 was found to significantly decreased LDHB activity and impaired hepatic lactate clearance, resulting in lactate accumulation in NAFLD progression.	1-(3-Chloro-4-Propoxyphenyl)methanamine	63-66	lysine acetyltransferase 2B	Homo sapiens	0-26
33248168-7	2021	P300/CBP-associated factor (PCAF)-mediated acetylation of LDHB K82 was found to significantly decreased LDHB activity and impaired hepatic lactate clearance, resulting in lactate accumulation in NAFLD progression.	1-(3-Chloro-4-Propoxyphenyl)methanamine	63-66	lysine acetyltransferase 2B	Homo sapiens	28-32
33248168-7	2021	P300/CBP-associated factor (PCAF)-mediated acetylation of LDHB K82 was found to significantly decreased LDHB activity and impaired hepatic lactate clearance, resulting in lactate accumulation in NAFLD progression.	Lactic Acid	139-146	lysine acetyltransferase 2B	Homo sapiens	0-26
33248168-7	2021	P300/CBP-associated factor (PCAF)-mediated acetylation of LDHB K82 was found to significantly decreased LDHB activity and impaired hepatic lactate clearance, resulting in lactate accumulation in NAFLD progression.	Lactic Acid	139-146	lysine acetyltransferase 2B	Homo sapiens	28-32
33248168-7	2021	P300/CBP-associated factor (PCAF)-mediated acetylation of LDHB K82 was found to significantly decreased LDHB activity and impaired hepatic lactate clearance, resulting in lactate accumulation in NAFLD progression.	Lactic Acid	171-178	lysine acetyltransferase 2B	Homo sapiens	0-26
33248168-7	2021	P300/CBP-associated factor (PCAF)-mediated acetylation of LDHB K82 was found to significantly decreased LDHB activity and impaired hepatic lactate clearance, resulting in lactate accumulation in NAFLD progression.	Lactic Acid	171-178	lysine acetyltransferase 2B	Homo sapiens	28-32
33248168-9	2021	The administration of embelin, the inhibitor of the PCAF and the generation of an acetylation-deficient mutant of LDHB ameliorated NASH.	embelin	22-29	lysine acetyltransferase 2B	Homo sapiens	52-56
33248168-10	2021	CONCLUSION: PCAF-dependent LDHB acetylation plays a key role in the development of hepatic lipid accumulation and inflammatory responses by imparing lactate clearance; and might be a potential therapeutic target for treatment of NASH.	Lactic Acid	149-156	lysine acetyltransferase 2B	Homo sapiens	12-16
33720323-9	2021	MTT proliferation assay and flow cytometric analysis showed that CAF-Exo promoted BC cell resistance to cisplatin and upregulated ABCB1 expression in BC cells by transferring LINC00355 to BC cells.	monooxyethylene trimethylolpropane tristearate	0-3	lysine acetyltransferase 2B	Homo sapiens	65-68
33720323-9	2021	MTT proliferation assay and flow cytometric analysis showed that CAF-Exo promoted BC cell resistance to cisplatin and upregulated ABCB1 expression in BC cells by transferring LINC00355 to BC cells.	Cisplatin	104-113	lysine acetyltransferase 2B	Homo sapiens	65-68
33670717-4	2021	Under CAF-inducing conditions, like hypoxia or cancer cell co-cultures, p62 ablation or autophagy inhibition with hydroxychloroquine (HCQ) impaired CAF activation and reduced transforming growth factor beta (TGFbeta) production, which impeded tumor growth.	Hydroxychloroquine	114-132	lysine acetyltransferase 2B	Homo sapiens	148-151
33621387-5	2021	Similarly, JSI-124 inhibited the capacity of CAF cells in promoting tumor growth, EMT, stemness as well as angiogenesis in orthotopic humanized breast cancer tumors.	cucurbitacin I	11-18	lysine acetyltransferase 2B	Homo sapiens	45-48
33621951-7	2021	Subsequently, we observed that the treatment of capmatinib resulted in the re-sensitization of CAF-co-cultured H1975 and HCC827 to osimertinib, in association with reduced EMT and self-renewal ability.	capmatinib	48-58	lysine acetyltransferase 2B	Homo sapiens	95-98
33621951-7	2021	Subsequently, we observed that the treatment of capmatinib resulted in the re-sensitization of CAF-co-cultured H1975 and HCC827 to osimertinib, in association with reduced EMT and self-renewal ability.	osimertinib	131-142	lysine acetyltransferase 2B	Homo sapiens	95-98
33670717-4	2021	Under CAF-inducing conditions, like hypoxia or cancer cell co-cultures, p62 ablation or autophagy inhibition with hydroxychloroquine (HCQ) impaired CAF activation and reduced transforming growth factor beta (TGFbeta) production, which impeded tumor growth.	Hydroxychloroquine	134-137	lysine acetyltransferase 2B	Homo sapiens	6-9
33670717-4	2021	Under CAF-inducing conditions, like hypoxia or cancer cell co-cultures, p62 ablation or autophagy inhibition with hydroxychloroquine (HCQ) impaired CAF activation and reduced transforming growth factor beta (TGFbeta) production, which impeded tumor growth.	Hydroxychloroquine	134-137	lysine acetyltransferase 2B	Homo sapiens	148-151
33462372-11	2021	Finally, CAF elimination by CAFs-PIT in vivo demonstrated that the combination of 5-FU and NIR-PIT succeeded in producing 70.9% tumor reduction, while 5-FU alone achieved only 13.3% reduction, suggesting the recovery of 5-FU sensitivity in CAF-rich tumors.	Fluorouracil	82-86	lysine acetyltransferase 2B	Homo sapiens	9-12
32060973-6	2020	In conclusion, our data suggest that curcumin reverses cell phenotype from CAF to PTF-like cells, and suppresses the CAF-mediated proliferation and tumorigenicity of Cal27 by inhibiting TSCC CAFs.	Curcumin	37-45	lysine acetyltransferase 2B	Homo sapiens	75-78
32812305-7	2021	RESULTS: Our data indicated that CAF enhanced CDDP resistance of VSCC cells in vitro.	Cisplatin	46-50	lysine acetyltransferase 2B	Homo sapiens	33-36
32812305-9	2021	Exosomal UCA1 derived from CAF conferred VSCC cell resistance to CDDP.	Cisplatin	65-69	lysine acetyltransferase 2B	Homo sapiens	27-30
32812305-12	2021	WEE1 was a direct target of miR-103a, and exosomal miR-103a from CAF weakened CDDP resistance of VSCC cells by WEE1.	Cisplatin	78-82	lysine acetyltransferase 2B	Homo sapiens	65-68
32812305-15	2021	CONCLUSION: Our findings suggested exosomal UCA1 derived from CAF conferred VSCC cell resistance to CDDP in vitro and in vivo at least partly through the miR-103a/WEE1 axis, highlighting a novel therapeutic method for improving the clinical benefits of CDDP chemotherapy in VSCC patients.	Cisplatin	100-104	lysine acetyltransferase 2B	Homo sapiens	62-65
32812305-15	2021	CONCLUSION: Our findings suggested exosomal UCA1 derived from CAF conferred VSCC cell resistance to CDDP in vitro and in vivo at least partly through the miR-103a/WEE1 axis, highlighting a novel therapeutic method for improving the clinical benefits of CDDP chemotherapy in VSCC patients.	Cisplatin	253-257	lysine acetyltransferase 2B	Homo sapiens	62-65
32434426-7	2020	The GM containing transforming growth factor-beta1 (TGF-beta1) were prepared to incorporate into 3D CAF (3D CAF-GM-TGF-beta1).	gm	4-6	lysine acetyltransferase 2B	Homo sapiens	100-103
32434426-7	2020	The GM containing transforming growth factor-beta1 (TGF-beta1) were prepared to incorporate into 3D CAF (3D CAF-GM-TGF-beta1).	gm	112-114	lysine acetyltransferase 2B	Homo sapiens	100-103
33187446-1	2020	The electronic structure parameter (WM) of the nuclear magnetic quadrupole moment (MQM) interaction in numerous open-shell metal monofluorides (viz., MgF, CaF, SrF, BaF, RaF, and PbF) is computed in the fully relativistic coupled-cluster framework.	metal monofluorides	123-142	lysine acetyltransferase 2B	Homo sapiens	155-158
32931156-3	2020	However, it is not clear how CAF subpopulations are formed in PDAC.	pdac	62-66	lysine acetyltransferase 2B	Homo sapiens	29-32
33165335-9	2020	Further immunohistochemical assay revealed that tumor tissues of the MKN-45 + CAF group displayed the most obvious vasculature formation, which facilitates tumor progression and metastasis.	mkn-45	69-75	lysine acetyltransferase 2B	Homo sapiens	78-81
32966758-6	2020	Furthermore, PCAF activity is tightly regulated by ATR (ataxia telangiectasia and Rad3-related), which phosphorylates PCAF on serine 264 (S264) to limit its association and activity at stalled forks.	Serine	126-132	lysine acetyltransferase 2B	Homo sapiens	13-17
32966758-6	2020	Furthermore, PCAF activity is tightly regulated by ATR (ataxia telangiectasia and Rad3-related), which phosphorylates PCAF on serine 264 (S264) to limit its association and activity at stalled forks.	Serine	126-132	lysine acetyltransferase 2B	Homo sapiens	118-122
32060973-6	2020	In conclusion, our data suggest that curcumin reverses cell phenotype from CAF to PTF-like cells, and suppresses the CAF-mediated proliferation and tumorigenicity of Cal27 by inhibiting TSCC CAFs.	Curcumin	37-45	lysine acetyltransferase 2B	Homo sapiens	117-120
32899119-8	2020	Thus, surface modified nanocarriers with a cyclic peptide binding to the PDGFRbeta or with mannose-6-phosphate binding to the IGFRII, effectively directed drug delivery to activated HSC/CAF in vivo.	Peptides, Cyclic	43-57	lysine acetyltransferase 2B	Homo sapiens	186-189
32967737-8	2021	Garcinol upregulated hepatic gluconeogenic enzymes expression and decreased PCAF activity.	garcinol	0-8	lysine acetyltransferase 2B	Homo sapiens	76-80
32967737-12	2021	Garcinol improves hepatic gluconeogenic enzyme expression in late pregnant sows, and this may be due to the mechanism of downregulating the acetylation of PGC-1alpha and FOXO1 induced by PCAF in isolated hepatocytes.	garcinol	0-8	lysine acetyltransferase 2B	Homo sapiens	187-191
32917154-5	2020	Importantly, we determined for the first time that circulating CAF levels correlate with worse prognosis and a lower probability of survival in Met-pa. Based on the CTC release induced by chemotherapy, we evaluated the efficacy of our previously developed cancer immunotherapy to eradicate CTCs from Met-pa blood using an ex vivo approach and demonstrate this could kill over 60% of CTCs.	met-pa	144-150	lysine acetyltransferase 2B	Homo sapiens	63-66
32917154-6	2020	CONCLUSION: Collectively, we found that CAF levels in Met-pa serve as a predictive biomarker for cancer prognosis.	met-pa	54-60	lysine acetyltransferase 2B	Homo sapiens	40-43
32899119-8	2020	Thus, surface modified nanocarriers with a cyclic peptide binding to the PDGFRbeta or with mannose-6-phosphate binding to the IGFRII, effectively directed drug delivery to activated HSC/CAF in vivo.	mannose-6-phosphate	91-110	lysine acetyltransferase 2B	Homo sapiens	186-189
32239298-5	2020	The effect of the AXL inhibitor, BGB324, on the CAF-induced aggressive phenotype of GC cells was also investigated.	bemcentinib	33-39	lysine acetyltransferase 2B	Homo sapiens	48-51
32239298-10	2020	BGB324, a small molecule inhibitor of AXL, suppressed the effects of CAF on GC cell lines.	bemcentinib	0-6	lysine acetyltransferase 2B	Homo sapiens	69-72
32119988-4	2020	Expression levels of the chromatin modifying enzymes EHMT2, ESCO1, HAT1, KAT2B, PRMT6 and SETD8 were upregulated by 50 muM of zearalenone exposure using PCR arrays, consistent with the results of global histone modifications.	Zearalenone	126-137	lysine acetyltransferase 2B	Homo sapiens	73-78
32843583-0	2020	Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype.	Y 27632	25-32	lysine acetyltransferase 2B	Homo sapiens	162-165
32615465-0	2020	Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects.	1,2,4-triazolophthalazine	70-95	lysine acetyltransferase 2B	Homo sapiens	130-134
32638026-4	2020	Various studies highlighted the ability of targeting CAF with pirfenidone (PFD), leading to increased efficacy of chemotherapy.	pirfenidone	62-73	lysine acetyltransferase 2B	Homo sapiens	53-56
32638026-4	2020	Various studies highlighted the ability of targeting CAF with pirfenidone (PFD), leading to increased efficacy of chemotherapy.	pirfenidone	75-78	lysine acetyltransferase 2B	Homo sapiens	53-56
32454390-0	2020	Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies.	triazolophthalazine	6-25	lysine acetyltransferase 2B	Homo sapiens	57-61
32454390-0	2020	Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies.	Hydrazones	26-35	lysine acetyltransferase 2B	Homo sapiens	57-61
32454390-8	2020	A follow up enzymatic assay indicated that these two compounds have comparable activities with that of bromosporine as PCAF inhibitors with IC50 values of 8.13 and 5.31 microM respectively.	Bromosporine	103-115	lysine acetyltransferase 2B	Homo sapiens	119-123
32531376-0	2020	The Ras-ERK1/2 signaling pathway regulates H3K9ac through PCAF to promote the development of pancreatic cancer.	h3k9ac	43-49	lysine acetyltransferase 2B	Homo sapiens	58-62
32843583-3	2020	The senescent HDFs induced by Y-27632 acquired a cancer-associated-fibroblast (CAF)-like phenotype to promote squamous cell carcinoma (SCC) cell growth in vitro.	Y 27632	30-37	lysine acetyltransferase 2B	Homo sapiens	79-82
32843583-7	2020	In summary, these results demonstrate for the first time that Y-27632 promotes cellular senescence in primary HDFs by inducing the expression of IGFBP-5 and that prolonged treatment with Y-27632 potentially transforms primary HDFs into CAF-like cells.	Y 27632	187-194	lysine acetyltransferase 2B	Homo sapiens	236-239
32371002-3	2020	Paclitaxel (PTX) and acriflavine (ACF) were identified as the most promising molecules to inhibit CAF development.	Paclitaxel	0-10	lysine acetyltransferase 2B	Homo sapiens	98-101
32371002-3	2020	Paclitaxel (PTX) and acriflavine (ACF) were identified as the most promising molecules to inhibit CAF development.	Paclitaxel	12-15	lysine acetyltransferase 2B	Homo sapiens	98-101
32371002-3	2020	Paclitaxel (PTX) and acriflavine (ACF) were identified as the most promising molecules to inhibit CAF development.	Acriflavine	21-32	lysine acetyltransferase 2B	Homo sapiens	98-101
32371002-3	2020	Paclitaxel (PTX) and acriflavine (ACF) were identified as the most promising molecules to inhibit CAF development.	Acriflavine	34-37	lysine acetyltransferase 2B	Homo sapiens	98-101
31629361-1	2020	Elevated circulating C-terminal agrin fragment (CAF) is a marker of neuromuscular junction degradation and sarcopenia.	Carbon	21-22	lysine acetyltransferase 2B	Homo sapiens	48-51
32075803-7	2020	We further demonstrated that inhibiting IDO1 and NADPH oxidases, NOX2 and NOX4, restored CD8+ T-cell proliferation by reducing reactive oxygen species (ROS) generation in CAF-induced MDSCs.	NADP	49-54	lysine acetyltransferase 2B	Homo sapiens	171-174
32075803-7	2020	We further demonstrated that inhibiting IDO1 and NADPH oxidases, NOX2 and NOX4, restored CD8+ T-cell proliferation by reducing reactive oxygen species (ROS) generation in CAF-induced MDSCs.	Oxygen	136-142	lysine acetyltransferase 2B	Homo sapiens	171-174
31908141-3	2020	Mechanistically, PCAF acetylation of ISX at lysine 69 promotes the interaction with acetylated bromodomain-containing protein 4 (BRD4) at lysine 332 in tumor cells, and the translocation of the resulting complex into the nucleus.	tyrosyl-lysine	44-50	lysine acetyltransferase 2B	Homo sapiens	17-21
31908141-3	2020	Mechanistically, PCAF acetylation of ISX at lysine 69 promotes the interaction with acetylated bromodomain-containing protein 4 (BRD4) at lysine 332 in tumor cells, and the translocation of the resulting complex into the nucleus.	tyrosyl-lysine	138-144	lysine acetyltransferase 2B	Homo sapiens	17-21
32122909-5	2020	We then examined the potential for CAF targeting, focusing on the ROS-producing enzyme NOX4, which is upregulated by CAF in many human cancers, and compared this with TGFbeta1 inhibition, a key regulator of the CAF phenotype.	ros	66-69	lysine acetyltransferase 2B	Homo sapiens	117-120
32122909-5	2020	We then examined the potential for CAF targeting, focusing on the ROS-producing enzyme NOX4, which is upregulated by CAF in many human cancers, and compared this with TGFbeta1 inhibition, a key regulator of the CAF phenotype.	ros	66-69	lysine acetyltransferase 2B	Homo sapiens	117-120
32239175-8	2020	We analyzed the heterozygous variants within the CDS region of the KAT2B genes and found that rs3021408 and rs17006625 were associated with the risk of CHD.	Cadmium	49-52	lysine acetyltransferase 2B	Homo sapiens	67-72
32104089-1	2020	Purpose: The present study aimed to examine the effects of nicotinamide (NAM) on cervical cancer-associated fibroblasts (CAF) for its in vitro efficacy, gross inhibition, and mechanism of inhibition.	Niacinamide	59-71	lysine acetyltransferase 2B	Homo sapiens	121-124
31234539-9	2019	Notably, CAPE was able to directly inhibit the activity of several HATs including p300, CREP-binding protein (CBP), and p300/CBP-associated factor (PCAF), further confirming that CAPE can function as an epigenetic modulator.	caffeic acid phenethyl ester	9-13	lysine acetyltransferase 2B	Homo sapiens	120-146
31611973-11	2019	CM from CAF (CM-CAF) increased cancer invasion and FITC-gelatin matrix degradation.	Fluorescein-5-isothiocyanate	51-55	lysine acetyltransferase 2B	Homo sapiens	8-11
31611973-11	2019	CM from CAF (CM-CAF) increased cancer invasion and FITC-gelatin matrix degradation.	Fluorescein-5-isothiocyanate	51-55	lysine acetyltransferase 2B	Homo sapiens	16-19
31140524-3	2019	The as-prepared CAs were synthesized via a polymeric sol-gel reaction and were labeled as CA-O, CA-Q, CA-F, CA-C, and CA-G.	cas	16-19	lysine acetyltransferase 2B	Homo sapiens	102-106
31781344-8	2019	After administration of a caffeine and/or melatonin supplement, there was a significant increase in progressive motility in the CAF (p = 0.005) and CM (p = 0.048) groups, as well as mitochondrial activity in the CM group (p < 0.05).	Caffeine	26-34	lysine acetyltransferase 2B	Homo sapiens	128-131
31781344-8	2019	After administration of a caffeine and/or melatonin supplement, there was a significant increase in progressive motility in the CAF (p = 0.005) and CM (p = 0.048) groups, as well as mitochondrial activity in the CM group (p < 0.05).	Melatonin	42-51	lysine acetyltransferase 2B	Homo sapiens	128-131
31417869-11	2019	We summarize various promising and novel approaches in mitigating the stimulatory effect of CAFs or MSCs on CSCs that have shown efficacies in preclinical models of desmoplastic tumors and highlight the unique advantages of CAF- or MSC-targeted therapies.	cafs	92-96	lysine acetyltransferase 2B	Homo sapiens	224-228
31234539-9	2019	Notably, CAPE was able to directly inhibit the activity of several HATs including p300, CREP-binding protein (CBP), and p300/CBP-associated factor (PCAF), further confirming that CAPE can function as an epigenetic modulator.	caffeic acid phenethyl ester	9-13	lysine acetyltransferase 2B	Homo sapiens	148-152
31234539-9	2019	Notably, CAPE was able to directly inhibit the activity of several HATs including p300, CREP-binding protein (CBP), and p300/CBP-associated factor (PCAF), further confirming that CAPE can function as an epigenetic modulator.	caffeic acid phenethyl ester	179-183	lysine acetyltransferase 2B	Homo sapiens	120-146
31234539-9	2019	Notably, CAPE was able to directly inhibit the activity of several HATs including p300, CREP-binding protein (CBP), and p300/CBP-associated factor (PCAF), further confirming that CAPE can function as an epigenetic modulator.	caffeic acid phenethyl ester	179-183	lysine acetyltransferase 2B	Homo sapiens	148-152
31042625-3	2019	Unlike other acetyltransferases and deacetylases, we found that the expression of acetyltransferase P300/CBP-associated factor (PCAF) is consistently decreased in three 5-FU resistant CRC cell lines.	Fluorouracil	169-173	lysine acetyltransferase 2B	Homo sapiens	128-132
30044210-0	2019	Deciphering the binding mode and mechanistic insights of pentadecylidenemalonate (1b) as activator of histone acetyltransferase PCAF.	pentadecylidenemalonate	57-80	lysine acetyltransferase 2B	Homo sapiens	128-132
30044210-3	2019	Pentadecylidenemalonate, a simplified analog of anacardic acid, was reported as first mixed inhibitor/activator of HATs which inhibits p300/CBP and activates PCAF.	pentadecylidenemalonate	0-23	lysine acetyltransferase 2B	Homo sapiens	158-162
30044210-3	2019	Pentadecylidenemalonate, a simplified analog of anacardic acid, was reported as first mixed inhibitor/activator of HATs which inhibits p300/CBP and activates PCAF.	anacardic acid	48-62	lysine acetyltransferase 2B	Homo sapiens	158-162
30044210-5	2019	In this study, pentadecylidenemalonate was taken for deciphering the binding mode, key interacting residues as well as mechanistic insights on PCAF and CBP as activator and inhibitor, respectively.	pentadecylidenemalonate	15-38	lysine acetyltransferase 2B	Homo sapiens	143-147
31042625-8	2019	However, knockdown of p21 abolishes the beneficial effects of PCAF overexpression on increasing the sensitivity of HCT116/5-FU cells to 5-FU.	Fluorouracil	136-140	lysine acetyltransferase 2B	Homo sapiens	62-66
31042625-10	2019	Our data suggest that PCAF-mediated p53 acetylation is an essential regulatory mechanism for increasing the susceptibility of CRC to 5-FU.	Fluorouracil	133-137	lysine acetyltransferase 2B	Homo sapiens	22-26
31042625-4	2019	Similarly, knockdown of PCAF in HCT116 CRC parental cell line also increases the resistance to 5-FU and attenuates 5-FU-induced apoptosis.	Fluorouracil	95-99	lysine acetyltransferase 2B	Homo sapiens	24-28
31042625-4	2019	Similarly, knockdown of PCAF in HCT116 CRC parental cell line also increases the resistance to 5-FU and attenuates 5-FU-induced apoptosis.	Fluorouracil	115-119	lysine acetyltransferase 2B	Homo sapiens	24-28
31042625-5	2019	Mechanistically, we demonstrated that increased binding of trimethylated histone H3K27 in the promoter region of PCAF attenuated its transcription in 5-FU resistant HCT116/5-FU cells.	Fluorouracil	150-154	lysine acetyltransferase 2B	Homo sapiens	113-117
31042625-5	2019	Mechanistically, we demonstrated that increased binding of trimethylated histone H3K27 in the promoter region of PCAF attenuated its transcription in 5-FU resistant HCT116/5-FU cells.	Fluorouracil	172-176	lysine acetyltransferase 2B	Homo sapiens	113-117
31042625-7	2019	Conversely, overexpression of PCAF in CRC cell lines increases p21 and their susceptibility to 5-FU in vitro and in vivo.	Fluorouracil	95-99	lysine acetyltransferase 2B	Homo sapiens	30-34
31042625-8	2019	However, knockdown of p21 abolishes the beneficial effects of PCAF overexpression on increasing the sensitivity of HCT116/5-FU cells to 5-FU.	Fluorouracil	122-126	lysine acetyltransferase 2B	Homo sapiens	62-66
30998845-0	2019	Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.	pyrrolo[3,2- d]pyrimidin-4-one	13-43	lysine acetyltransferase 2B	Homo sapiens	111-137
30868675-10	2019	Conversely, suppression of JNK activation by specific inhibitor retarded the effect of CAF-CM and ANXA3 on cisplatin sensitivity.	Cisplatin	107-116	lysine acetyltransferase 2B	Homo sapiens	87-93
29768408-4	2018	In one of the families with additional cardiomyopathy and steroid-resistant nephrotic syndrome (SRNS), we found a homozygous variant in KAT2B, encoding the lysine acetyltransferase 2B, with impact on KAT2B protein levels in patient fibroblasts, suggesting that this second mutation might contribute to the increased disease spectrum.	Steroids	58-65	lysine acetyltransferase 2B	Homo sapiens	136-141
30868675-5	2019	In this study, we investigated the role of CAF in cisplatin resistance of lung cancer cells.	Cisplatin	50-59	lysine acetyltransferase 2B	Homo sapiens	43-46
30868675-6	2019	By using conditioned medium from CAF (CAF-CM), we found that CAF decreased the sensitivity of lung cancer cells to cisplatin.	Cisplatin	115-124	lysine acetyltransferase 2B	Homo sapiens	33-36
30868675-6	2019	By using conditioned medium from CAF (CAF-CM), we found that CAF decreased the sensitivity of lung cancer cells to cisplatin.	Cisplatin	115-124	lysine acetyltransferase 2B	Homo sapiens	38-44
30868675-6	2019	By using conditioned medium from CAF (CAF-CM), we found that CAF decreased the sensitivity of lung cancer cells to cisplatin.	Cisplatin	115-124	lysine acetyltransferase 2B	Homo sapiens	38-41
30868675-9	2019	Further study showed that CAF-CM enhanced cisplatin resistance by inhibiting cisplatin-induced apoptosis, determined by repression of caspase-3 and caspase-8, through activation of the ANXA3/JNK pathway.	Cisplatin	42-51	lysine acetyltransferase 2B	Homo sapiens	26-32
30868675-9	2019	Further study showed that CAF-CM enhanced cisplatin resistance by inhibiting cisplatin-induced apoptosis, determined by repression of caspase-3 and caspase-8, through activation of the ANXA3/JNK pathway.	Cisplatin	77-86	lysine acetyltransferase 2B	Homo sapiens	26-32
31105691-5	2019	DAPT also inhibited the contact-dependent induction of CXCL8, but not of CCL5, in TNFalpha- and IL-1beta-stimulated TNBC:MSC/CAF co-cultures; some level of heterogeneity between the responses of different TNBC cell lines was noted, with MDA-MB-231:MSC/CAF co-cultures being the most sensitive to DAPT.	dapt	0-4	lysine acetyltransferase 2B	Homo sapiens	125-128
31105691-5	2019	DAPT also inhibited the contact-dependent induction of CXCL8, but not of CCL5, in TNFalpha- and IL-1beta-stimulated TNBC:MSC/CAF co-cultures; some level of heterogeneity between the responses of different TNBC cell lines was noted, with MDA-MB-231:MSC/CAF co-cultures being the most sensitive to DAPT.	dapt	0-4	lysine acetyltransferase 2B	Homo sapiens	252-255
30833716-7	2019	Deletions or point mutations identified several lysine residues in different delta-catenin domains involved in PCAF-mediated delta-catenin downregulation.	Lysine	48-54	lysine acetyltransferase 2B	Homo sapiens	111-115
29671337-0	2019	Nonhistone targets of KAT2A and KAT2B implicated in cancer biology 1.	nonhistone	0-10	lysine acetyltransferase 2B	Homo sapiens	32-37
30305648-4	2018	Here, we show that the accessibility of beta-catenin to the promoter region of its target genes is regulated by developmental stage-specific histone acetyltransferases (HATs), lysine acetyltransferase 2B (KAT2B), and cAMP-response element-binding protein (CREB)-binding protein (CBP).	Cyclic AMP	217-221	lysine acetyltransferase 2B	Homo sapiens	205-210
30047926-4	2018	We identified a Ras inhibitor, RASAL3, as epigenetically silenced in human prostatic CAF, leading to oncogenic Ras activity driving macropinocytosis-mediated glutamine synthesis.	Glutamine	158-167	lysine acetyltransferase 2B	Homo sapiens	85-88
30047926-10	2018	Identification of epigenetic regulation of Ras activity in prostatic CAF revealed RASAL3 as a sensor for metabolic and neuroendocrine reprogramming in prostate cancer patients failing ADT.	adt	184-187	lysine acetyltransferase 2B	Homo sapiens	69-72
30937935-5	2019	CAF investigates if AF patients randomized to dabigatran etexilate will have long-term higher cognition scores and lower rates of dementia compared in the long term to dose-adjusted warfarin (International Normalized Ratio [INR]: 2.0-3.0).	Dabigatran	46-66	lysine acetyltransferase 2B	Homo sapiens	0-3
30937935-5	2019	CAF investigates if AF patients randomized to dabigatran etexilate will have long-term higher cognition scores and lower rates of dementia compared in the long term to dose-adjusted warfarin (International Normalized Ratio [INR]: 2.0-3.0).	Warfarin	182-190	lysine acetyltransferase 2B	Homo sapiens	0-3
30678426-6	2019	The top ten hub genes (CDC20, H2AFX, ENO1, ACTB, ISG15,KAT2B, HNRNPD, YWHAE, GJA1 and CAV1) were identified, which play important roles in critical signalingpathways that regulate the process of oxidation-reduction reaction and carboxylic acid metabolism.	Carboxylic Acids	228-243	lysine acetyltransferase 2B	Homo sapiens	55-60
30409902-10	2019	Silencing of p300/CBP-associated factor (PCAF), which acetylates HIF-1alpha, blocked PGE2-mediated increases in acetyl-HIF-1alpha, HIF-1alpha, and aromatase.	Dinoprostone	85-89	lysine acetyltransferase 2B	Homo sapiens	13-39
30409902-10	2019	Silencing of p300/CBP-associated factor (PCAF), which acetylates HIF-1alpha, blocked PGE2-mediated increases in acetyl-HIF-1alpha, HIF-1alpha, and aromatase.	Dinoprostone	85-89	lysine acetyltransferase 2B	Homo sapiens	41-45
30482390-6	2019	Thus, the P/CAF-MDM2-p53-p21 axis enables the escape from mitotic cell death and confers resistance to nocodazole in HCT116(p53+/+) cells with SIRT2 suppression.	Nocodazole	103-113	lysine acetyltransferase 2B	Homo sapiens	10-15
30426593-2	2019	We have previously reported that CAF isolated from lymphoma samples increase anaerobic glycolysis and decrease intracellular production of reactive oxygen species, promoting the survival of tumor cells.	Reactive Oxygen Species	139-162	lysine acetyltransferase 2B	Homo sapiens	33-36
30426593-4	2019	As direct contact between lymphoma cells and CAF was not indispensable to survival support, we identified that the humoral factor pyruvate was significantly secreted by CAF.	Pyruvic Acid	130-138	lysine acetyltransferase 2B	Homo sapiens	45-48
30426593-4	2019	As direct contact between lymphoma cells and CAF was not indispensable to survival support, we identified that the humoral factor pyruvate was significantly secreted by CAF.	Pyruvic Acid	130-138	lysine acetyltransferase 2B	Homo sapiens	169-172
30426593-6	2019	Metabolome analysis of lymphoma cells in coculture with CAF demonstrated that intermediates in the citric acid cycle were significantly increased, indicating that tumor cells produced energy by aerobic metabolism.	Citric Acid	99-110	lysine acetyltransferase 2B	Homo sapiens	56-59
30426593-7	2019	These findings indicate that energy production in lymphoma cells is regulated in coordination not only with anaerobic glycolysis, but also with aerobic metabolism termed the reverse-Warburg effect, involving the secretion of pyruvate from CAF resulting in increased use of the citric acid cycle in lymphoma cells.	Pyruvic Acid	225-233	lysine acetyltransferase 2B	Homo sapiens	239-242
30426593-7	2019	These findings indicate that energy production in lymphoma cells is regulated in coordination not only with anaerobic glycolysis, but also with aerobic metabolism termed the reverse-Warburg effect, involving the secretion of pyruvate from CAF resulting in increased use of the citric acid cycle in lymphoma cells.	Citric Acid	277-288	lysine acetyltransferase 2B	Homo sapiens	239-242
29228881-0	2018	Unravelling novel congeners from acetyllysine mimicking ligand targeting a lysine acetyltransferase PCAF bromodomain.	N-epsilon-Acetyl-L-lysine	33-45	lysine acetyltransferase 2B	Homo sapiens	100-104
29228881-2	2018	In this study, a three featured E-Pharmacophore (ARR) was generated based on acetyllysine mimicking inhibitor of PCAF BRD which is available as co-crystal structure (PDB ID: 5FDZ).	N-epsilon-Acetyl-L-lysine	77-89	lysine acetyltransferase 2B	Homo sapiens	113-117
29968042-1	2018	In this study, the formation of caffeine/dapsone (CAF/DAP) cocrystals by scalable production methods, such as liquid-assisted grinding (LAG) and spray drying, was investigated in the context of the potential use of processed cocrystal powder for pulmonary delivery.	Caffeine	32-40	lysine acetyltransferase 2B	Homo sapiens	50-57
29968042-1	2018	In this study, the formation of caffeine/dapsone (CAF/DAP) cocrystals by scalable production methods, such as liquid-assisted grinding (LAG) and spray drying, was investigated in the context of the potential use of processed cocrystal powder for pulmonary delivery.	Dapsone	41-48	lysine acetyltransferase 2B	Homo sapiens	50-57
29968042-2	2018	A CAF/DAP cocrystal (1:1 M ratio) was successfully prepared by slow evaporation from both acetone and ethyl acetate.	Acetone	90-97	lysine acetyltransferase 2B	Homo sapiens	2-9
29968042-2	2018	A CAF/DAP cocrystal (1:1 M ratio) was successfully prepared by slow evaporation from both acetone and ethyl acetate.	ethyl acetate	102-115	lysine acetyltransferase 2B	Homo sapiens	2-9
29902349-6	2018	Nab-PTX treatment was carried out during the coculture system or during preparation of CAF conditioned medium.	nab-ptx	0-7	lysine acetyltransferase 2B	Homo sapiens	87-90
29902349-11	2018	Moreover, nab-PTX increased CXCL10 expression of cancer cells which blocked CAF IL-6 expression and secretion.	nab	10-13	lysine acetyltransferase 2B	Homo sapiens	76-79
29902349-11	2018	Moreover, nab-PTX increased CXCL10 expression of cancer cells which blocked CAF IL-6 expression and secretion.	ptx	14-17	lysine acetyltransferase 2B	Homo sapiens	76-79
29769197-4	2018	Here, we demonstrate that CAF-secreted HGF increases extracellular lactate levels in HNSCC via upregulation of glycolysis.	Lactic Acid	67-74	lysine acetyltransferase 2B	Homo sapiens	26-29
29768408-4	2018	In one of the families with additional cardiomyopathy and steroid-resistant nephrotic syndrome (SRNS), we found a homozygous variant in KAT2B, encoding the lysine acetyltransferase 2B, with impact on KAT2B protein levels in patient fibroblasts, suggesting that this second mutation might contribute to the increased disease spectrum.	Steroids	58-65	lysine acetyltransferase 2B	Homo sapiens	156-183
29768408-4	2018	In one of the families with additional cardiomyopathy and steroid-resistant nephrotic syndrome (SRNS), we found a homozygous variant in KAT2B, encoding the lysine acetyltransferase 2B, with impact on KAT2B protein levels in patient fibroblasts, suggesting that this second mutation might contribute to the increased disease spectrum.	Steroids	58-65	lysine acetyltransferase 2B	Homo sapiens	200-205
29346528-5	2018	We uncovered an uncharacterized lncRNA, FLJ22447, which was remarkably up-regulated in CAFs, referred to LncRNA-CAF (Lnc-CAF) hereafter.	cafs	87-91	lysine acetyltransferase 2B	Homo sapiens	112-115
29472718-7	2018	Furthermore, AC-4-130 synergistically increased the cytotoxicity of the JAK1/2 inhibitor Ruxolitinib and the p300/pCAF inhibitor Garcinol.	AC-4-130	13-21	lysine acetyltransferase 2B	Homo sapiens	114-118
29472718-7	2018	Furthermore, AC-4-130 synergistically increased the cytotoxicity of the JAK1/2 inhibitor Ruxolitinib and the p300/pCAF inhibitor Garcinol.	garcinol	129-137	lysine acetyltransferase 2B	Homo sapiens	114-118
29363544-2	2018	Preclinical mouse models suggest that near-depletion of cancer-associated fibroblasts (CAF) carries a risk of accelerating PDAC progression, underscoring the need to concurrently target key signaling mechanisms that drive the malignant attributes of both CAF and PDAC cells.	pdac	123-127	lysine acetyltransferase 2B	Homo sapiens	87-90
29440709-6	2018	We demonstrated that lysine 830 of BRCA1 is a preferential acetylation site by pCAF and tested its function in embryonic stem (ES) cells by changing lysine 830 to arginine using a transcription activator-like effector nuclease (TALEN) system.	Lysine	21-27	lysine acetyltransferase 2B	Homo sapiens	79-83
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	57-63	lysine acetyltransferase 2B	Homo sapiens	92-96
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	57-63	lysine acetyltransferase 2B	Homo sapiens	263-267
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	227-230	lysine acetyltransferase 2B	Homo sapiens	92-96
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	227-230	lysine acetyltransferase 2B	Homo sapiens	263-267
29555684-7	2018	A series of biochemical analyses disclosed that the host lysine acetyltransferases GCN5 and PCAF acetylate NP in vitro MS experiments identified three lysine residues as acetylation targets in the host cells and suggested that Lys-31 and Lys-90 are acetylated by PCAF and GCN5, respectively.	Lysine	238-241	lysine acetyltransferase 2B	Homo sapiens	92-96
28950424-2	2018	Testosterone administration improves physical function in some studies; however, its effects on serum circulating CAF concentrations remain unknown.	Testosterone	0-12	lysine acetyltransferase 2B	Homo sapiens	114-117
29568385-3	2018	There is a growing body of evidence suggesting that a pro-inflammatory microenvironment (e.g. ROS and cytokines) promotes CAF formation during tumorigenesis, although the exact mechanisms involved remain unclear.	ros	94-97	lysine acetyltransferase 2B	Homo sapiens	122-125
29568385-5	2018	Based on the phenotype of in vitro-generated CAFs, we demonstrate that midostaurin, a clinically relevant compound, selectively eliminates CAF-like cells deficient in base excision repair and prevents their stimulatory role in cancer cell growth and migration.	midostaurin	71-82	lysine acetyltransferase 2B	Homo sapiens	45-48
28892046-12	2018	Importantly, guided by the NR profile of CAFs, retinoic acid receptor beta and androgen receptor antagonists were identified for concurrent therapy with cisplatin, resulting in the inhibition of chemoresistance in recurred SCC:CAF xenografts.	Cisplatin	153-162	lysine acetyltransferase 2B	Homo sapiens	41-44
28950424-3	2018	Here we evaluate the effects of testosterone administration on circulating CAF levels in mobility-limited men with low testosterone aged 65 or older participating in the Testosterone in Older Men with Mobility Limitations (TOM) Trial.	Testosterone	32-44	lysine acetyltransferase 2B	Homo sapiens	75-78
28950424-4	2018	We analyzed the difference in change in serum CAF levels between testosterone and placebo groups, as well as its association with muscle strength and physical function.	Testosterone	65-77	lysine acetyltransferase 2B	Homo sapiens	46-49
28950424-5	2018	Association of change in serum CAF levels with serum total (TT) and free testosterone (FT) was also evaluated.	Testosterone	73-85	lysine acetyltransferase 2B	Homo sapiens	31-34
28950424-11	2018	These findings suggest that improvement in physical function with testosterone replacement in older men with mobility limitations and elevated CAF levels is mediated by mechanisms other than stabilization of the NMJ.	Testosterone	66-78	lysine acetyltransferase 2B	Homo sapiens	143-146
27457910-3	2017	Here we report that caffeine, at concentrations representing moderate to high levels of consumption in humans, induces an NMDA receptor-independent form of LTP (CAF LTP) in the CA1 region of the hippocampus by promoting calcium-dependent secretion of BDNF, which subsequently activates TrkB-mediated signaling required for the expression of CAF LTP.	Caffeine	20-28	lysine acetyltransferase 2B	Homo sapiens	161-164
29267519-11	2018	We concluded that the use of dexamethasone as a preemptive and postoperative medication was more suitable as a drug therapeutic protocol for CAF + CTG.	Dexamethasone	29-42	lysine acetyltransferase 2B	Homo sapiens	141-144
29166553-3	2018	Topical nitrates (TN) heal CAF effectively but recurrences are common.	Nitrates	8-16	lysine acetyltransferase 2B	Homo sapiens	27-30
27457910-3	2017	Here we report that caffeine, at concentrations representing moderate to high levels of consumption in humans, induces an NMDA receptor-independent form of LTP (CAF LTP) in the CA1 region of the hippocampus by promoting calcium-dependent secretion of BDNF, which subsequently activates TrkB-mediated signaling required for the expression of CAF LTP.	Caffeine	20-28	lysine acetyltransferase 2B	Homo sapiens	341-344
27457910-3	2017	Here we report that caffeine, at concentrations representing moderate to high levels of consumption in humans, induces an NMDA receptor-independent form of LTP (CAF LTP) in the CA1 region of the hippocampus by promoting calcium-dependent secretion of BDNF, which subsequently activates TrkB-mediated signaling required for the expression of CAF LTP.	Calcium	220-227	lysine acetyltransferase 2B	Homo sapiens	161-164
27457910-3	2017	Here we report that caffeine, at concentrations representing moderate to high levels of consumption in humans, induces an NMDA receptor-independent form of LTP (CAF LTP) in the CA1 region of the hippocampus by promoting calcium-dependent secretion of BDNF, which subsequently activates TrkB-mediated signaling required for the expression of CAF LTP.	Calcium	220-227	lysine acetyltransferase 2B	Homo sapiens	341-344
28518141-0	2017	CAF-secreted CXCL1 conferred radioresistance by regulating DNA damage response in a ROS-dependent manner in esophageal squamous cell carcinoma.	Reactive Oxygen Species	84-87	lysine acetyltransferase 2B	Homo sapiens	0-3
28759294-6	2017	The p300/PCAF inhibitor garcinol also destabilized the ADA3 protein in a proteasome-dependent manner and an ADA3 mutant with K R mutations exhibited a marked increase in half-life, consistent with opposite role of acetylation and ubiquitination of ADA3 on shared lysine residues.	garcinol	24-32	lysine acetyltransferase 2B	Homo sapiens	9-13
29051480-4	2017	We provide evidence that NOX4-derived reactive oxygen species (ROS) inhibits P300/CBP-associated factor (PCAF)-dependent acetylation and lysosomal degradation of the pyruvate kinase-M2 isoform (PKM2).	Reactive Oxygen Species	38-61	lysine acetyltransferase 2B	Homo sapiens	77-103
29051480-4	2017	We provide evidence that NOX4-derived reactive oxygen species (ROS) inhibits P300/CBP-associated factor (PCAF)-dependent acetylation and lysosomal degradation of the pyruvate kinase-M2 isoform (PKM2).	Reactive Oxygen Species	38-61	lysine acetyltransferase 2B	Homo sapiens	105-109
29051480-4	2017	We provide evidence that NOX4-derived reactive oxygen species (ROS) inhibits P300/CBP-associated factor (PCAF)-dependent acetylation and lysosomal degradation of the pyruvate kinase-M2 isoform (PKM2).	Reactive Oxygen Species	63-66	lysine acetyltransferase 2B	Homo sapiens	77-103
29051480-4	2017	We provide evidence that NOX4-derived reactive oxygen species (ROS) inhibits P300/CBP-associated factor (PCAF)-dependent acetylation and lysosomal degradation of the pyruvate kinase-M2 isoform (PKM2).	Reactive Oxygen Species	63-66	lysine acetyltransferase 2B	Homo sapiens	105-109
28277613-0	2017	Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF).	Resveratrol	43-54	lysine acetyltransferase 2B	Homo sapiens	104-107
28277613-6	2017	We have investigated here for the first time the effects of RES on the physiology of PCa CAF in the context of TME.	Resveratrol	60-63	lysine acetyltransferase 2B	Homo sapiens	89-92
28717171-6	2017	In vitro KAT assays confirmed that salicylate directly inhibited PCAF/Kat2b, Tip60/Kat5 and hMOF/Kat8, and this inhibition was likely involved in the reversal of EMT in the metastatic prostate cancer cell line PC-3.	Salicylates	35-45	lysine acetyltransferase 2B	Homo sapiens	65-69
28717171-6	2017	In vitro KAT assays confirmed that salicylate directly inhibited PCAF/Kat2b, Tip60/Kat5 and hMOF/Kat8, and this inhibition was likely involved in the reversal of EMT in the metastatic prostate cancer cell line PC-3.	Salicylates	35-45	lysine acetyltransferase 2B	Homo sapiens	70-75
28518141-5	2017	CAF-secreted CXCL1 inhibited the expression of reactive oxygen species (ROS)-scavenging enzyme superoxide dismutase 1, leading to increased ROS accumulation following radiation, by which DNA damage repair was enhanced and the radioresistance was mediated.	Reactive Oxygen Species	47-70	lysine acetyltransferase 2B	Homo sapiens	0-3
28518141-5	2017	CAF-secreted CXCL1 inhibited the expression of reactive oxygen species (ROS)-scavenging enzyme superoxide dismutase 1, leading to increased ROS accumulation following radiation, by which DNA damage repair was enhanced and the radioresistance was mediated.	Reactive Oxygen Species	72-75	lysine acetyltransferase 2B	Homo sapiens	0-3
28518141-5	2017	CAF-secreted CXCL1 inhibited the expression of reactive oxygen species (ROS)-scavenging enzyme superoxide dismutase 1, leading to increased ROS accumulation following radiation, by which DNA damage repair was enhanced and the radioresistance was mediated.	Reactive Oxygen Species	140-143	lysine acetyltransferase 2B	Homo sapiens	0-3
28258248-6	2017	Moreover, HGF in CAF matrix attenuated paclitaxel (PAC)-caused inhibition of cell proliferation and increase in cell apoptosis through activating c-Met/PI3K/Akt and GRP78 pathways in SKOV3 and HO-8910 cells.	Paclitaxel	39-49	lysine acetyltransferase 2B	Homo sapiens	17-20
28515832-1	2017	Dietary supplements are widely used to enhance sport performance and the combination of carbohydrate and caffeine (CHO+CAF) has yielded particularly high performance gains.	Carbohydrates	88-100	lysine acetyltransferase 2B	Homo sapiens	119-122
28515832-1	2017	Dietary supplements are widely used to enhance sport performance and the combination of carbohydrate and caffeine (CHO+CAF) has yielded particularly high performance gains.	Caffeine	105-113	lysine acetyltransferase 2B	Homo sapiens	119-122
27638235-9	2017	Serum CAF correlated positively with serum creatinine, cystatin C and negatively with eGFR on day 1, day 2 and at 6 months after kidney transplantation.	Creatinine	43-53	lysine acetyltransferase 2B	Homo sapiens	6-9
28258248-6	2017	Moreover, HGF in CAF matrix attenuated paclitaxel (PAC)-caused inhibition of cell proliferation and increase in cell apoptosis through activating c-Met/PI3K/Akt and GRP78 pathways in SKOV3 and HO-8910 cells.	Paclitaxel	51-54	lysine acetyltransferase 2B	Homo sapiens	17-20
28287402-8	2017	Fatty acids (FAs) prevented CIDEC deacetylation by promoting the dissociation of CIDEC from HDAC6, which resulted in increased association of CIDEC with PCAF on the endoplasmic reticulum.	Fatty Acids	0-11	lysine acetyltransferase 2B	Homo sapiens	153-157
28287402-8	2017	Fatty acids (FAs) prevented CIDEC deacetylation by promoting the dissociation of CIDEC from HDAC6, which resulted in increased association of CIDEC with PCAF on the endoplasmic reticulum.	Fatty Acids	13-16	lysine acetyltransferase 2B	Homo sapiens	153-157
27702820-5	2017	RNA sequencing was used to develop a high-confidence gene signature that predicts for disease recurrence in tamoxifen-treated patients with ER+ breast cancer.Results: We demonstrate that ER+ breast cancers contain two CAF subtypes defined by CD146 expression.	Tamoxifen	108-117	lysine acetyltransferase 2B	Homo sapiens	218-221
28237867-12	2017	CONCLUSION: The lenvatinib PFS benefit was maintained regardless of baseline CAF or BRAF/RAS status.	lenvatinib	16-26	lysine acetyltransferase 2B	Homo sapiens	77-80
27702820-9	2017	Gene expression profiles of patient breast tumors with predominantly CD146neg CAFs correlate with inferior clinical response to tamoxifen and worse patient outcomes.Conclusions: Our data suggest that CAF composition contributes to treatment response and patient outcomes in ER+ breast cancer and should be considered a target for drug development.	Tamoxifen	128-137	lysine acetyltransferase 2B	Homo sapiens	78-81
28053092-0	2017	Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells.	2-octenal	97-103	lysine acetyltransferase 2B	Homo sapiens	71-75
28107962-2	2017	The designed polymer film (polymer CAF) could be used as a new support matrix for fabrication of a label-free electrochemical immunosensor with high sensitivity, good stability and repeatability.	Polymers	13-20	lysine acetyltransferase 2B	Homo sapiens	35-38
28053092-0	2017	Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells.	Tretinoin	103-116	lysine acetyltransferase 2B	Homo sapiens	71-75
28053092-3	2017	Herein, we show that p300/CREB-binding protein-associated factor (PCAF), a histone acetyltransferase (HAT), is a prerequisite for ATRA-induced granulocytic differentiation in leukemia cells.	Tretinoin	130-134	lysine acetyltransferase 2B	Homo sapiens	66-70
28053092-4	2017	We found that PCAF expression was markedly increased in leukemia cell lines (NB4 and HL-60) and primary APL cells during ATRA-induced granulocytic differentiation.	Tretinoin	121-125	lysine acetyltransferase 2B	Homo sapiens	14-18
28053092-5	2017	Consistent with these results, the expression of PCAF was markedly up-regulated in the bone marrow cells of APL patients who received ATRA-containing chemotherapy.	Tretinoin	134-138	lysine acetyltransferase 2B	Homo sapiens	49-53
28053092-6	2017	The knockdown of PCAF inhibited ATRA-induced granulocytic differentiation in leukemia cell lines and primary APL cells.	Tretinoin	32-36	lysine acetyltransferase 2B	Homo sapiens	17-21
28053092-8	2017	Acetylome analysis identified the acetylated proteins after ATRA treatment, and we found that histone H3, a known PCAF acetylation substrate, was preferentially acetylated by the ATRA treatment.	Tretinoin	179-183	lysine acetyltransferase 2B	Homo sapiens	114-118
28053092-10	2017	These results strongly support our hypothesis that PCAF is induced and activated by ATRA, and the subsequent acetylation of PCAF substrates promotes granulocytic differentiation in leukemia cells.	Tretinoin	84-88	lysine acetyltransferase 2B	Homo sapiens	51-55
27774669-5	2017	And we further characterized P300/cyclic adenosine monophosphate response element binding protein-binding protein-associated factor (PCAF) and Sirtuin 7 as the enzymes regulating K323 acetylation from both directions in liver cancer cells.	P-300	29-33	lysine acetyltransferase 2B	Homo sapiens	133-137
27774669-5	2017	And we further characterized P300/cyclic adenosine monophosphate response element binding protein-binding protein-associated factor (PCAF) and Sirtuin 7 as the enzymes regulating K323 acetylation from both directions in liver cancer cells.	Cyclic AMP	34-64	lysine acetyltransferase 2B	Homo sapiens	133-137
27922075-4	2016	Meanwhile, Interleukin-11(IL-11) was significantly up-regulated in the CAF stimulated by cisplatin.	Cisplatin	89-98	lysine acetyltransferase 2B	Homo sapiens	71-74
28002667-3	2017	Herein, we report GSK4027 as a chemical probe for the PCAF/GCN5 bromodomain, together with GSK4028 as an enantiomeric negative control.	GSK4027	18-25	lysine acetyltransferase 2B	Homo sapiens	54-58
28002667-4	2017	The probe was optimized from a weakly potent, nonselective pyridazinone hit to deliver high potency for the PCAF/GCN5 bromodomain, high solubility, cellular target engagement, and >=18000-fold selectivity over the BET family, together with >=70-fold selectivity over the wider bromodomain families.	2-phenyl-3(2H)-pyridazinone	59-71	lysine acetyltransferase 2B	Homo sapiens	108-112
28123853-6	2017	In this study, we show that the CAF-mediated enhancement of pancreatic cancer cell migration and metastasis was blocked by curcumin.	Curcumin	123-131	lysine acetyltransferase 2B	Homo sapiens	32-35
27966810-2	2017	Iterative cycles of rational inhibitor design and biophysical characterization led to the discovery of the triazolopthalazine-based L-45 (dubbed L-Moses) as the first potent, selective, and cell-active PCAF bromodomain (Brd) inhibitor.	triazolopthalazine	107-125	lysine acetyltransferase 2B	Homo sapiens	202-206
27966810-2	2017	Iterative cycles of rational inhibitor design and biophysical characterization led to the discovery of the triazolopthalazine-based L-45 (dubbed L-Moses) as the first potent, selective, and cell-active PCAF bromodomain (Brd) inhibitor.	L-Moses	132-136	lysine acetyltransferase 2B	Homo sapiens	202-206
27774655-12	2017	Propolis, Caf and Caf + Cin stimulated H2 O2 production, whereas propolis, Cin, Cou, and Caf + Cin + Cou induced a higher fungicidal activity.	Hydrogen Peroxide	39-44	lysine acetyltransferase 2B	Homo sapiens	10-13
27774655-12	2017	Propolis, Caf and Caf + Cin stimulated H2 O2 production, whereas propolis, Cin, Cou, and Caf + Cin + Cou induced a higher fungicidal activity.	Hydrogen Peroxide	39-44	lysine acetyltransferase 2B	Homo sapiens	18-21
27774655-12	2017	Propolis, Caf and Caf + Cin stimulated H2 O2 production, whereas propolis, Cin, Cou, and Caf + Cin + Cou induced a higher fungicidal activity.	Hydrogen Peroxide	39-44	lysine acetyltransferase 2B	Homo sapiens	18-21
27283621-2	2016	Fluorine was determined at CaF wavelength, 606.440nm in a graphite tube applying a pyrolysis temperature of 1000 C and a molecule forming temperature of 2200 C. The limit of detection and characteristic mass of the method were 0.20ng and 0.17ng of fluorine, respectively.	Fluorine	0-8	lysine acetyltransferase 2B	Homo sapiens	27-30
27760942-2	2016	Pathological findings showed invasive ductal carcinoma that was ER and PgR positive and HER2 negative.5 -FU and tamoxifen were administered for 2 years as adjuvant therapy.Bone metastasis was found in 2002, and endocrine therapy was started, using anastrozole, exemestane, letrozole, medroxyprogesterone acetate, and fulvestrant.However, liver, lung, pleural, penetiral, and lymph-node metastases were observed, and the following chemotherapy regimen was administered: CAF, capecitabine, paclitaxel, vinorelbine, gemcitabine, methotrexate plus mitomycin C, and eribulin.Then, estrogen therapy with ethinylestradiol( EE2)was started in December 2013.T he pleural effusion disappeared and the liver metastases were reduced.After 11 months of progression-free survival(PFS), regrowth of the liver metastases was seen.Thus, everolimus plus exemestane was administered, and approximately 8 months of PFS was obtained.Therefore, both EE2 and everolimus are effective therapy even for heavily pretreated metastatic breast cancer.	Fluorouracil	102-107	lysine acetyltransferase 2B	Homo sapiens	469-472
26202629-9	2016	KAT2B encodes a transcriptional regulator in the cyclic adenosine monophosphate and dopamine signaling pathways, and rs9829896-C was associated with expression of genes in these pathways: reduced CREBBP expression (P = 0.011) and increased OPRM1 expression (P = 0.016), both in AAs only.	Cyclic AMP	49-79	lysine acetyltransferase 2B	Homo sapiens	0-5
26202629-9	2016	KAT2B encodes a transcriptional regulator in the cyclic adenosine monophosphate and dopamine signaling pathways, and rs9829896-C was associated with expression of genes in these pathways: reduced CREBBP expression (P = 0.011) and increased OPRM1 expression (P = 0.016), both in AAs only.	Dopamine	84-92	lysine acetyltransferase 2B	Homo sapiens	0-5
27509880-7	2016	Furthermore, our global analysis of gene expression, which was focused on genes involved in the molecular regulation of MHC class II genes, showed enhancement of pro-apoptotic PCAF and CIITA after the combination of 5-FU and depsipeptide.	Fluorouracil	216-220	lysine acetyltransferase 2B	Homo sapiens	176-180
27496707-7	2016	The ability of patient-derived CAF with SOCS1 methylation to promote PDAC growth was more robust than CAF without SOCS1 methylation.	pdac	69-73	lysine acetyltransferase 2B	Homo sapiens	31-34
26988768-5	2016	Pre-exercise, at the end of exercise, and 5-min postexercise blood pH, base excess, and bicarbonate ion concentration ([HCO3(-)]) were significantly elevated for BIC and BIC-CAF compared with CAF and PLA.	Bicarbonates	88-99	lysine acetyltransferase 2B	Homo sapiens	174-177
27563925-5	2016	HSP90 inhibitors radicicol and 17-DMAG inhibited contractility and reduced the migration of CAF in scratch assays.	monorden	17-26	lysine acetyltransferase 2B	Homo sapiens	92-95
27563925-5	2016	HSP90 inhibitors radicicol and 17-DMAG inhibited contractility and reduced the migration of CAF in scratch assays.	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	31-38	lysine acetyltransferase 2B	Homo sapiens	92-95
27177087-3	2016	CAF targeting remains a promising challenge for PDA, a devastating disease where treatments focusing on cancer cells have failed.	2,3-piperidinedicarboxylic acid	48-51	lysine acetyltransferase 2B	Homo sapiens	0-3
26802082-7	2016	Pharmacological inhibition of KAT2B by anacardic acid in NCM460 cells reduced the levels of histone H4 lysine 5 acetylation [H4K5ac] and interleukin-10 [IL-10] in a dose-dependent manner.	Lysine	103-109	lysine acetyltransferase 2B	Homo sapiens	30-35
26980707-2	2016	In our screening study to identify natural compounds with lysine acetyltransferase inhibitor (KATi) activity, oridonin was found to possess acetyltransferase-inhibitory effects on multiple acetyltransferases including P300, GCN5, Tip60, and pCAF.	oridonin	110-118	lysine acetyltransferase 2B	Homo sapiens	241-245
26988768-5	2016	Pre-exercise, at the end of exercise, and 5-min postexercise blood pH, base excess, and bicarbonate ion concentration ([HCO3(-)]) were significantly elevated for BIC and BIC-CAF compared with CAF and PLA.	Bicarbonates	120-124	lysine acetyltransferase 2B	Homo sapiens	174-177
26988768-6	2016	TLIM (median; interquartile range) was significantly greater for CAF (399; 350-415 s; P = 0.039; r = 0.6) and BIC-CAF (367; 333-402 s; P = 0.028; r = 0.6) compared with BIC (313: 284-448 s) although not compared with PLA (358; 290-433 s; P = 0.249, r = 0.3 and P = 0.099 and r = 0.5, respectively).	Bicarbonates	110-113	lysine acetyltransferase 2B	Homo sapiens	114-117
26484667-2	2015	In such context we report the role of polygalacturonic acid (PGA) on the reducing activity of caffeic acid (CAF) towards V(V).	polygalacturonic acid	38-59	lysine acetyltransferase 2B	Homo sapiens	108-111
26870991-2	2016	In this study, we evaluated the efficacy of the thiazole derivative 3-methylcyclopentylidene-[4-(4"-chlorophenyl)thiazol-2-yl]hydrazone (CPTH6), a novel pCAF and Gcn5 histone acetyltransferase inhibitor, as a small molecule that preferentially targets lung cancer stem-like cells (LCSCs) derived from non-small cell lung cancer (NSCLC) patients.	Thiazoles	48-56	lysine acetyltransferase 2B	Homo sapiens	153-157
26870991-2	2016	In this study, we evaluated the efficacy of the thiazole derivative 3-methylcyclopentylidene-[4-(4"-chlorophenyl)thiazol-2-yl]hydrazone (CPTH6), a novel pCAF and Gcn5 histone acetyltransferase inhibitor, as a small molecule that preferentially targets lung cancer stem-like cells (LCSCs) derived from non-small cell lung cancer (NSCLC) patients.	3-methylcyclopentylidene-(4-(4'-chlorophenyl)thiazol-2-yl)hydrazone	68-135	lysine acetyltransferase 2B	Homo sapiens	153-157
26870991-2	2016	In this study, we evaluated the efficacy of the thiazole derivative 3-methylcyclopentylidene-[4-(4"-chlorophenyl)thiazol-2-yl]hydrazone (CPTH6), a novel pCAF and Gcn5 histone acetyltransferase inhibitor, as a small molecule that preferentially targets lung cancer stem-like cells (LCSCs) derived from non-small cell lung cancer (NSCLC) patients.	4-(4-chlorophenyl)-N-[(Z)-(3-methylcyclopentylidene)amino]-1,3-thiazol-2-amine	137-142	lysine acetyltransferase 2B	Homo sapiens	153-157
26469812-10	2016	CAL change from 6 months to 5 years was greater for CTG + CAF (0.26 mm) than CMX + CAF (-0.21 mm).	ctg	52-55	lysine acetyltransferase 2B	Homo sapiens	58-61
26630274-4	2015	METHODS: Serum CAF levels were measured in 71 elderly patients with diabetic nephropathy using a newly developed commercial ELISA kit (Neurotune ).	neurotune	135-144	lysine acetyltransferase 2B	Homo sapiens	15-18
26449626-8	2015	Using receiver operating characteristics (ROC), we calculated the optimal CAF value to identify patients with muscle wasting as >87.5 pmol/L, which had a sensitivity of 78.9% and a specificity of 43.7%.	Aminoglutethimide	125-131	lysine acetyltransferase 2B	Homo sapiens	74-77
26336878-6	2015	Significant correlations between CAF-TEM1-positivity or CAF-TEM1-intensity and RFS, OS, or COS were observed (P < 0.001, Kaplan-Meier curves); however, no significant correlation between vessel-TEM1-intensity and RFS, OS, or COS was observed.	Osmium	84-86	lysine acetyltransferase 2B	Homo sapiens	33-36
26336878-6	2015	Significant correlations between CAF-TEM1-positivity or CAF-TEM1-intensity and RFS, OS, or COS were observed (P < 0.001, Kaplan-Meier curves); however, no significant correlation between vessel-TEM1-intensity and RFS, OS, or COS was observed.	carbonyl sulfide	91-94	lysine acetyltransferase 2B	Homo sapiens	33-36
26336878-6	2015	Significant correlations between CAF-TEM1-positivity or CAF-TEM1-intensity and RFS, OS, or COS were observed (P < 0.001, Kaplan-Meier curves); however, no significant correlation between vessel-TEM1-intensity and RFS, OS, or COS was observed.	carbonyl sulfide	91-94	lysine acetyltransferase 2B	Homo sapiens	56-59
26484667-2	2015	In such context we report the role of polygalacturonic acid (PGA) on the reducing activity of caffeic acid (CAF) towards V(V).	polygalacturonic acid	61-64	lysine acetyltransferase 2B	Homo sapiens	108-111
26484667-2	2015	In such context we report the role of polygalacturonic acid (PGA) on the reducing activity of caffeic acid (CAF) towards V(V).	caffeic acid	94-106	lysine acetyltransferase 2B	Homo sapiens	108-111
26484667-4	2015	An o-quinone was identified as the first product of the reaction which is further involved in the formation of CAF dimers.	2-benzoquinone	3-12	lysine acetyltransferase 2B	Homo sapiens	111-114
26484667-7	2015	The redox reaction was faster in the presence of PGA and a higher yield of V(IV) was found in the 4.0-6.0 pH range with respect to the CAF-V(V) binary system.	polygalacturonic acid	49-52	lysine acetyltransferase 2B	Homo sapiens	135-138
26484667-10	2015	Results showed that PGA reduced significantly the phytotoxic effects of the V(V)-CAF system.	polygalacturonic acid	20-23	lysine acetyltransferase 2B	Homo sapiens	81-84
25800736-4	2015	We identified that PCAF interacts with and acetylates EZH2 mainly at lysine 348 (K348).	Lysine	69-75	lysine acetyltransferase 2B	Homo sapiens	19-23
25755069-5	2015	In human cell lines, siRNA mediated knockdown of GCN5 or PCAF, or chemical inhibition of GCN5 enzymatic activity, increases the sensitivity to CG-1521 and SAHA.	cysteinylglycine	143-145	lysine acetyltransferase 2B	Homo sapiens	57-61
25755069-5	2015	In human cell lines, siRNA mediated knockdown of GCN5 or PCAF, or chemical inhibition of GCN5 enzymatic activity, increases the sensitivity to CG-1521 and SAHA.	Vorinostat	155-159	lysine acetyltransferase 2B	Homo sapiens	57-61
26115510-8	2015	Moreover, treatment with the CAF matrix inhibited spontaneous and medium or high dose of paclitaxel-induced A549 cell apoptosis.	Paclitaxel	89-99	lysine acetyltransferase 2B	Homo sapiens	29-32
26115510-9	2015	Inhibition of PI3K or GRP78 attenuated the CAF matrix-mediated inhibition on paclitaxel-induced A549 cell apoptosis.	Paclitaxel	77-87	lysine acetyltransferase 2B	Homo sapiens	43-46
26115510-10	2015	Our data indicated that HGF in the CAF matrix activated the Met/PI3K/AKT and up-regulated GRP78 expression, promoting chemoresistance to paclitaxel-mediated apoptosis in A549 cells.	Paclitaxel	137-147	lysine acetyltransferase 2B	Homo sapiens	35-38
25834145-3	2015	Our results demonstrate that CAF secretome-triggered chemoresistance is abolished upon inhibition of the protein synthesis mTOR/4E-BP1 regulatory pathway which we found highly activated in primary cultures of alpha-SMA-positive CAFs, isolated from human PDAC resections.	pdac	254-258	lysine acetyltransferase 2B	Homo sapiens	29-32
25884315-1	2015	This study aimed to investigate whether isolated or combined carbohydrate (CHO) and caffeine (CAF) supplementation have beneficial effects on performance during soccer-related tests performed after a previous training session.	Caffeine	84-92	lysine acetyltransferase 2B	Homo sapiens	94-97
25800736-4	2015	We identified that PCAF interacts with and acetylates EZH2 mainly at lysine 348 (K348).	1-(2-bromoethyl)adamantane	81-85	lysine acetyltransferase 2B	Homo sapiens	19-23
25960846-9	2015	Also our study showed that controlled CINV episodes in patients who received CMF regimen were better than the regimen including adriamycin (CAF, CHOP) into both granisetron (p=0.06) and metoclopramid (p=0.04).	Doxorubicin	128-138	lysine acetyltransferase 2B	Homo sapiens	140-143
25855960-3	2015	Here, we show that PCAF can directly acetylate cytoplasmic GLI1 protein at lysine 518, preventing its nuclear translocation and promoter occupancy, and consequently suppressing Hedgehog (Hh) signaling in HCC.	Lysine	75-81	lysine acetyltransferase 2B	Homo sapiens	19-23
25855960-7	2015	PCAF was also found to sensitize HCC cells to 5-fluorouracil (5-FU) treatment by regulating GLI1/Bcl-2/BAX axis-dependent apoptosis.	Fluorouracil	46-60	lysine acetyltransferase 2B	Homo sapiens	0-4
25855960-7	2015	PCAF was also found to sensitize HCC cells to 5-fluorouracil (5-FU) treatment by regulating GLI1/Bcl-2/BAX axis-dependent apoptosis.	Fluorouracil	62-66	lysine acetyltransferase 2B	Homo sapiens	0-4
25855960-8	2015	In vivo experiments also confirmed the regulatory effect of PCAF on the GLI1/Bcl-2/BAX axis and its synergistic antitumor effects with 5-FU.	Fluorouracil	135-139	lysine acetyltransferase 2B	Homo sapiens	60-64
25855960-10	2015	Together, these results show that PCAF can induce cell apoptosis by modulating a GLI1/Bcl-2/BAX axis that in turn suppresses HCC progression, and suggest that 5-FU may exert a stronger anti-tumor effect in patients with PCAF expression in HCC tumors.	Fluorouracil	159-163	lysine acetyltransferase 2B	Homo sapiens	34-38
25855960-10	2015	Together, these results show that PCAF can induce cell apoptosis by modulating a GLI1/Bcl-2/BAX axis that in turn suppresses HCC progression, and suggest that 5-FU may exert a stronger anti-tumor effect in patients with PCAF expression in HCC tumors.	Fluorouracil	159-163	lysine acetyltransferase 2B	Homo sapiens	220-224
25738345-12	2015	Adjunctive application of a CTG under a CAF increased the probability of achieving complete root coverage in maxillary Miller Class I and II defects (61.5% versus 83.3%; P = .38).	ctg	28-31	lysine acetyltransferase 2B	Homo sapiens	40-43
25186664-5	2015	RESULTS: A significant inverse correlation for men was observed between CAF and PWCFT (r = -0.602; P = 0.05), but not for women (r = 0.208; P = 0.54).	pwcft	80-85	lysine acetyltransferase 2B	Homo sapiens	72-75
25352149-7	2015	RESULTS: Serum CAF concentrations were highly correlated with serum concentrations of creatinine (r = 0.806, p = 0.002), BUN (r = 0.727, p = 0.007), cystatin c (r = 0.839, p = 0.001) and inversely to 24-h urinary output (r = -0.669, p = 0.017).	Creatinine	86-96	lysine acetyltransferase 2B	Homo sapiens	15-18
25352149-8	2015	RRF was inversely correlated with serum concentrations of CAF, cystatin c and creatinine being highest for CAF (r = -0.734, p = 0.007) followed by cystatin c (r = -0.65, p = 0.022) and creatinine (r = -0.606, p = 0.037).	Creatinine	78-88	lysine acetyltransferase 2B	Homo sapiens	107-110
25203060-4	2015	We show that p300/CBP associated factor (PCAF)/GCN5 activity depends on the presence of a distal arginine residue of its histone H3 substrate.	Arginine	97-105	lysine acetyltransferase 2B	Homo sapiens	41-45
25203060-5	2015	Modifications to H3 Arg8 decrease PCAF acetylation of H3 Lys14, and kinetic data indicate that arginine citrullination has the strongest effect in decreasing acetylation.	Arginine	95-103	lysine acetyltransferase 2B	Homo sapiens	34-38
25501279-6	2015	Mechanistically, PCAF-mediated Akt1 acetylation enhanced Akt1 phosphorylation at both sites of Thr(308) and Ser(473) and further promoted the proliferation of glioblastoma cells.	Threonine	95-98	lysine acetyltransferase 2B	Homo sapiens	17-21
25501279-6	2015	Mechanistically, PCAF-mediated Akt1 acetylation enhanced Akt1 phosphorylation at both sites of Thr(308) and Ser(473) and further promoted the proliferation of glioblastoma cells.	Serine	108-111	lysine acetyltransferase 2B	Homo sapiens	17-21
25333655-0	2015	Identification of structural features of 2-alkylidene-1,3-dicarbonyl derivatives that induce inhibition and/or activation of histone acetyltransferases KAT3B/p300 and KAT2B/PCAF.	2-alkylidene-1,3-dicarbonyl	41-68	lysine acetyltransferase 2B	Homo sapiens	167-172
25333655-0	2015	Identification of structural features of 2-alkylidene-1,3-dicarbonyl derivatives that induce inhibition and/or activation of histone acetyltransferases KAT3B/p300 and KAT2B/PCAF.	2-alkylidene-1,3-dicarbonyl	41-68	lysine acetyltransferase 2B	Homo sapiens	173-177
25333655-4	2015	Herein, we report that manipulation of the carbonyl functions of a series of analogues of SPV106 yielded different activity profiles against KAT2B and KAT3B (pure KAT2B activator, pan-inhibitor, or mixed KAT2B activator/KAT3B inhibitor).	pentadecylidenemalonate 1b	90-96	lysine acetyltransferase 2B	Homo sapiens	141-146
25333655-4	2015	Herein, we report that manipulation of the carbonyl functions of a series of analogues of SPV106 yielded different activity profiles against KAT2B and KAT3B (pure KAT2B activator, pan-inhibitor, or mixed KAT2B activator/KAT3B inhibitor).	pentadecylidenemalonate 1b	90-96	lysine acetyltransferase 2B	Homo sapiens	163-168
25333655-4	2015	Herein, we report that manipulation of the carbonyl functions of a series of analogues of SPV106 yielded different activity profiles against KAT2B and KAT3B (pure KAT2B activator, pan-inhibitor, or mixed KAT2B activator/KAT3B inhibitor).	pentadecylidenemalonate 1b	90-96	lysine acetyltransferase 2B	Homo sapiens	163-168
25807640-9	2015	Serum levels of CAF significantly correlated with creatinine (r = 0.623, p < 0.001) and cystatin C (r = 0.578, p < 0.001).	Creatinine	50-60	lysine acetyltransferase 2B	Homo sapiens	16-19
25807640-10	2015	Multiple linear regression analyses adjusting CAF for inflammatory parameters (i.e., WBC, CRP, interleukin 6, PCT), age, and gender showed a strong correlation between CAF and creatinine (r = 0.643, p < 0.001).	Creatinine	176-186	lysine acetyltransferase 2B	Homo sapiens	46-49
25807640-10	2015	Multiple linear regression analyses adjusting CAF for inflammatory parameters (i.e., WBC, CRP, interleukin 6, PCT), age, and gender showed a strong correlation between CAF and creatinine (r = 0.643, p < 0.001).	Creatinine	176-186	lysine acetyltransferase 2B	Homo sapiens	168-171
25404235-4	2015	A four-point pharmacophore with two hydrogen bond acceptor, one aromatic ring and one hydrophobic feature, was generated for six highly active isothiazolone derivatives as PCAF inhibitors in order to elucidate their anticancer activity.	Hydrogen	36-44	lysine acetyltransferase 2B	Homo sapiens	172-176
25404235-4	2015	A four-point pharmacophore with two hydrogen bond acceptor, one aromatic ring and one hydrophobic feature, was generated for six highly active isothiazolone derivatives as PCAF inhibitors in order to elucidate their anticancer activity.	isothiazolone	143-156	lysine acetyltransferase 2B	Homo sapiens	172-176
24933521-3	2014	With the same dose of NHS-AA, the cross-linking degree for CAF was lower than those for CSF and CBF.	nhs-aa	22-28	lysine acetyltransferase 2B	Homo sapiens	59-62
24800886-7	2014	Belinostat induced a dose-dependent reduction in the expression of EZH2 and SUZ12, HDAC-1, HDAC-2, and histone acetyltransferase PCAF (p300/CBP-associated factor).	belinostat	0-10	lysine acetyltransferase 2B	Homo sapiens	103-133
24800886-7	2014	Belinostat induced a dose-dependent reduction in the expression of EZH2 and SUZ12, HDAC-1, HDAC-2, and histone acetyltransferase PCAF (p300/CBP-associated factor).	belinostat	0-10	lysine acetyltransferase 2B	Homo sapiens	135-161
24933521-5	2014	When the dose of NHS-AA increased from 0.1 to 1.5, the water contents of CSF and CBF increased while that of CAF had no obvious change.	nhs-aa	17-23	lysine acetyltransferase 2B	Homo sapiens	109-112
24933521-6	2014	With lower dose of NHS-AA (0.1), CAF possessed higher value of G" (87.3Pa) and the best thermal stability (47.6 C).	nhs-aa	19-25	lysine acetyltransferase 2B	Homo sapiens	33-36
24732800-6	2014	Here we found that activation was dependent on the histone H3 lysine 9 (H3K9) demethylase activity of LSD1, which removes repressive methyl marks from dimethylated H3K9 (H3K9Me2), to facilitate subsequent H3K9 acetylation by the NeuroD1-associated histone acetyltransferase, P300/CBP-associated factor (PCAF).	Lysine	62-68	lysine acetyltransferase 2B	Homo sapiens	275-301
24710408-0	2014	Cancer-associated fibroblasts expressing CXCL14 rely upon NOS1-derived nitric oxide signaling for their tumor-supporting properties.	Nitric Oxide	71-83	lysine acetyltransferase 2B	Homo sapiens	0-29
24803643-5	2014	Importantly, it was demonstrated that CAFs secrete elevated quantities of insulin-like growth factor-binding proteins (IGFBPs) that are both necessary for CAF-mediated anoikis inhibition and sufficient to block anoikis in the absence of CAFs.	cafs	237-241	lysine acetyltransferase 2B	Homo sapiens	38-41
24732800-6	2014	Here we found that activation was dependent on the histone H3 lysine 9 (H3K9) demethylase activity of LSD1, which removes repressive methyl marks from dimethylated H3K9 (H3K9Me2), to facilitate subsequent H3K9 acetylation by the NeuroD1-associated histone acetyltransferase, P300/CBP-associated factor (PCAF).	Lysine	62-68	lysine acetyltransferase 2B	Homo sapiens	303-307
24423233-1	2014	BACKGROUND: p300/CBP associating factor (PCAF, also known as KAT2B for lysine acetyltransferase 2B) is a catalytic subunit of megadalton metazoan complex ATAC (Ada-Two-A containing complex) for acetylation of histones.	ada-two-a	160-169	lysine acetyltransferase 2B	Homo sapiens	12-39
24406210-5	2014	The molecular characteristics of a CAF remain in evolution since CAFs show operational flexibility.	cafs	65-69	lysine acetyltransferase 2B	Homo sapiens	35-38
24474698-3	2014	Some of the novel compounds, 2-(3-aminopropylamino) pyridine 1-oxide derivatives, could be effective inhibitors of PCAF bromodomain/Tat-AcK50 association.	2-(3-aminopropylamino) pyridine 1-oxide	29-68	lysine acetyltransferase 2B	Homo sapiens	115-119
24474698-4	2014	Specifically, 2-(3-aminopropylamino)-5-(hydroxymethyl)pyridine 1-oxide hydrochloride (15) and the 5-((3-aminopropylamino)methyl) derivative (20) were found to be effective ligands for the PCAF BRD pocket.	2-(3-aminopropylamino)-5-(hydroxymethyl)pyridine 1-oxide hydrochloride	14-84	lysine acetyltransferase 2B	Homo sapiens	188-192
24686445-4	2014	Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury.	Lysine	154-157	lysine acetyltransferase 2B	Homo sapiens	114-118
24481325-7	2014	Furthermore, TAM, E2, and G1 promoted CAF proliferation and cell-cycle progression, both of which were blocked by GPER interference, the selective GPER antagonist G15, the epidermal growth factor receptor (EGFR) inhibitor AG1478, and the ERK1/2 inhibitor U0126.	RTKI cpd	222-228	lysine acetyltransferase 2B	Homo sapiens	38-41
24481325-7	2014	Furthermore, TAM, E2, and G1 promoted CAF proliferation and cell-cycle progression, both of which were blocked by GPER interference, the selective GPER antagonist G15, the epidermal growth factor receptor (EGFR) inhibitor AG1478, and the ERK1/2 inhibitor U0126.	U 0126	255-260	lysine acetyltransferase 2B	Homo sapiens	38-41
24481325-10	2014	Accordingly, GPER-mediated CAF-dependent estrogenic effects on the tumor-associated stroma are conceivable, and CAF is likely to contribute to breast cancer progression, especially TAM resistance, via a positive feedback loop involving GPER/EGFR/ERK signaling and E2 production.	Tamoxifen	181-184	lysine acetyltransferase 2B	Homo sapiens	112-115
24423233-1	2014	BACKGROUND: p300/CBP associating factor (PCAF, also known as KAT2B for lysine acetyltransferase 2B) is a catalytic subunit of megadalton metazoan complex ATAC (Ada-Two-A containing complex) for acetylation of histones.	ada-two-a	160-169	lysine acetyltransferase 2B	Homo sapiens	41-45
24423233-1	2014	BACKGROUND: p300/CBP associating factor (PCAF, also known as KAT2B for lysine acetyltransferase 2B) is a catalytic subunit of megadalton metazoan complex ATAC (Ada-Two-A containing complex) for acetylation of histones.	ada-two-a	160-169	lysine acetyltransferase 2B	Homo sapiens	61-66
24423233-1	2014	BACKGROUND: p300/CBP associating factor (PCAF, also known as KAT2B for lysine acetyltransferase 2B) is a catalytic subunit of megadalton metazoan complex ATAC (Ada-Two-A containing complex) for acetylation of histones.	ada-two-a	160-169	lysine acetyltransferase 2B	Homo sapiens	71-98
23932781-4	2013	Acetylation at these three lysine residues is stimulated by P300/calcium-binding protein (CBP)-associated factor (PCAF) acetyltransferase under high glucose and increases ACLY stability by blocking its ubiquitylation and degradation.	Lysine	27-33	lysine acetyltransferase 2B	Homo sapiens	114-118
23956145-11	2014	CONCLUSIONS: The combination of mTOR inhibitor and vinblastine given over an extended continuous schedule is safe, associated with a reduction in circulating angiogenic factor (CAF) VEGFR2 and resulted in clinical responses.	Vinblastine	51-62	lysine acetyltransferase 2B	Homo sapiens	177-180
23661605-0	2013	Phenethyl isothiocyanate inhibits androgen receptor-regulated transcriptional activity in prostate cancer cells through suppressing PCAF.	phenethyl isothiocyanate	0-24	lysine acetyltransferase 2B	Homo sapiens	132-136
23661605-4	2013	Here, we assessed the effects of PEITC on PCAF expression and AR-regulated transcriptional activity in PCa cells.	phenethyl isothiocyanate	33-38	lysine acetyltransferase 2B	Homo sapiens	42-46
23661605-6	2013	Interestingly, overexpression of PCAF attenuated the inhibitory effects of PEITC on dihydrotestosterone-stimulated AR transcriptional activity.	phenethyl isothiocyanate	75-80	lysine acetyltransferase 2B	Homo sapiens	33-37
23661605-6	2013	Interestingly, overexpression of PCAF attenuated the inhibitory effects of PEITC on dihydrotestosterone-stimulated AR transcriptional activity.	Dihydrotestosterone	84-103	lysine acetyltransferase 2B	Homo sapiens	33-37
23661605-8	2013	PEITC treatment significantly decreased PCAF expression and promoted transcription of miR-17 in LNCaP cells.	phenethyl isothiocyanate	0-5	lysine acetyltransferase 2B	Homo sapiens	40-44
23661605-9	2013	Functional inhibition of miR-17 attenuated the suppression of PCAF in cells treated by PEITC.	phenethyl isothiocyanate	87-92	lysine acetyltransferase 2B	Homo sapiens	62-66
23661605-10	2013	CONCLUSION: Our results indicate that PEITC inhibits AR-regulated transcriptional activity and cell growth of PCa cells through miR-17-mediated suppression of PCAF, suggesting a new mechanism by which PEITC modulates PCa cell growth.	phenethyl isothiocyanate	38-43	lysine acetyltransferase 2B	Homo sapiens	159-163
23661605-10	2013	CONCLUSION: Our results indicate that PEITC inhibits AR-regulated transcriptional activity and cell growth of PCa cells through miR-17-mediated suppression of PCAF, suggesting a new mechanism by which PEITC modulates PCa cell growth.	phenethyl isothiocyanate	201-206	lysine acetyltransferase 2B	Homo sapiens	159-163
23907428-14	2013	CONCLUSION: These data suggest that nab-paclitaxel and gemcitabine decreases CAF content inducing a marked alteration in cancer stroma that results in tumour softening.	nab	36-39	lysine acetyltransferase 2B	Homo sapiens	77-80
23907428-14	2013	CONCLUSION: These data suggest that nab-paclitaxel and gemcitabine decreases CAF content inducing a marked alteration in cancer stroma that results in tumour softening.	Paclitaxel	40-50	lysine acetyltransferase 2B	Homo sapiens	77-80
23907428-14	2013	CONCLUSION: These data suggest that nab-paclitaxel and gemcitabine decreases CAF content inducing a marked alteration in cancer stroma that results in tumour softening.	gemcitabine	55-66	lysine acetyltransferase 2B	Homo sapiens	77-80
24345448-0	2014	Azide-alkyne cycloaddition affording enzymatically tunable bisubstrate based inhibitors of histone acetyltransferase PCAF.	Azides	0-5	lysine acetyltransferase 2B	Homo sapiens	117-121
24345448-0	2014	Azide-alkyne cycloaddition affording enzymatically tunable bisubstrate based inhibitors of histone acetyltransferase PCAF.	Alkynes	6-12	lysine acetyltransferase 2B	Homo sapiens	117-121
24345448-0	2014	Azide-alkyne cycloaddition affording enzymatically tunable bisubstrate based inhibitors of histone acetyltransferase PCAF.	bisubstrate	59-70	lysine acetyltransferase 2B	Homo sapiens	117-121
24037888-10	2013	CONCLUSIONS: These observations demonstrate that 1) HOXA10 associates with and is acetylated by PCAF at lysines K338 and K339 in Ishikawa cells and 2) HOXA10-PCAF association impairs embryo implantation by inhibiting ITGB3 protein expression in endometrial epithelial cells.	Lysine	104-111	lysine acetyltransferase 2B	Homo sapiens	96-100
24037888-10	2013	CONCLUSIONS: These observations demonstrate that 1) HOXA10 associates with and is acetylated by PCAF at lysines K338 and K339 in Ishikawa cells and 2) HOXA10-PCAF association impairs embryo implantation by inhibiting ITGB3 protein expression in endometrial epithelial cells.	Lysine	104-111	lysine acetyltransferase 2B	Homo sapiens	158-162
23932781-4	2013	Acetylation at these three lysine residues is stimulated by P300/calcium-binding protein (CBP)-associated factor (PCAF) acetyltransferase under high glucose and increases ACLY stability by blocking its ubiquitylation and degradation.	Glucose	149-156	lysine acetyltransferase 2B	Homo sapiens	114-118
23157591-0	2013	Inhibition of PCAF by anacardic acid derivative leads to apoptosis and breaks resistance to DNA damage in BCR-ABL-expressing cells.	anacardic acid	22-36	lysine acetyltransferase 2B	Homo sapiens	14-18
23760262-1	2013	PCAF and GCN5 acetylate cyclin A at specific lysine residues targeting it for degradation at mitosis.	Lysine	45-51	lysine acetyltransferase 2B	Homo sapiens	0-4
23591450-10	2013	Transcriptional assays endorsed the notion that PCAF may be involved in the determination of the SCO2 and TIGAR cellular levels, thereby, regulating cellular energy metabolism, a view supported by assays measuring lactic acid production and oxygen consumption in cells ectopically expressing PCAF.	Lactic Acid	214-225	lysine acetyltransferase 2B	Homo sapiens	48-52
23157591-4	2013	Our previous data showed that a derivative of anacardic acid - small molecule MG153, which has been designed and synthesized to optimize the HAT inhibitory potency of anacardic acid, is a potent inhibitor of p300/CBP associated factor (PCAF) acetyltransferase.	anacardic acid	46-60	lysine acetyltransferase 2B	Homo sapiens	236-240
23157591-4	2013	Our previous data showed that a derivative of anacardic acid - small molecule MG153, which has been designed and synthesized to optimize the HAT inhibitory potency of anacardic acid, is a potent inhibitor of p300/CBP associated factor (PCAF) acetyltransferase.	mg153	78-83	lysine acetyltransferase 2B	Homo sapiens	236-240
23157591-4	2013	Our previous data showed that a derivative of anacardic acid - small molecule MG153, which has been designed and synthesized to optimize the HAT inhibitory potency of anacardic acid, is a potent inhibitor of p300/CBP associated factor (PCAF) acetyltransferase.	anacardic acid	167-181	lysine acetyltransferase 2B	Homo sapiens	236-240
23591450-10	2013	Transcriptional assays endorsed the notion that PCAF may be involved in the determination of the SCO2 and TIGAR cellular levels, thereby, regulating cellular energy metabolism, a view supported by assays measuring lactic acid production and oxygen consumption in cells ectopically expressing PCAF.	Oxygen	241-247	lysine acetyltransferase 2B	Homo sapiens	48-52
23696899-8	2013	Significantly, down-regulation of HMGA2 or p300, PCAF and GCN5 HATs sensitizes the cells to gemcitabine in three-dimensional collagen.	gemcitabine	92-103	lysine acetyltransferase 2B	Homo sapiens	49-53
23305175-2	2013	The aims of the present study were to examine the relationship between Treg and patient outcome and to investigate whether Treg induction is influenced by the characteristics of cancer-associated fibroblasts (CAF) in lung adenocarcinoma.	treg	123-127	lysine acetyltransferase 2B	Homo sapiens	209-212
23583737-1	2013	The results of quantum mechanical calculations, including binding energies and results of the population analysis show that the GC and AT base pair complexes are more stable than the CAF-X ones (where CAF is caffeine and X=adenine (A), thymine (T), cytosine (C) and guanine (G)).	Caffeine	208-216	lysine acetyltransferase 2B	Homo sapiens	183-186
23583737-1	2013	The results of quantum mechanical calculations, including binding energies and results of the population analysis show that the GC and AT base pair complexes are more stable than the CAF-X ones (where CAF is caffeine and X=adenine (A), thymine (T), cytosine (C) and guanine (G)).	Caffeine	208-216	lysine acetyltransferase 2B	Homo sapiens	201-204
23583737-1	2013	The results of quantum mechanical calculations, including binding energies and results of the population analysis show that the GC and AT base pair complexes are more stable than the CAF-X ones (where CAF is caffeine and X=adenine (A), thymine (T), cytosine (C) and guanine (G)).	Adenine	223-230	lysine acetyltransferase 2B	Homo sapiens	183-186
23583737-1	2013	The results of quantum mechanical calculations, including binding energies and results of the population analysis show that the GC and AT base pair complexes are more stable than the CAF-X ones (where CAF is caffeine and X=adenine (A), thymine (T), cytosine (C) and guanine (G)).	Cytosine	249-257	lysine acetyltransferase 2B	Homo sapiens	183-186
23583737-1	2013	The results of quantum mechanical calculations, including binding energies and results of the population analysis show that the GC and AT base pair complexes are more stable than the CAF-X ones (where CAF is caffeine and X=adenine (A), thymine (T), cytosine (C) and guanine (G)).	Cytosine	249-257	lysine acetyltransferase 2B	Homo sapiens	201-204
23583737-1	2013	The results of quantum mechanical calculations, including binding energies and results of the population analysis show that the GC and AT base pair complexes are more stable than the CAF-X ones (where CAF is caffeine and X=adenine (A), thymine (T), cytosine (C) and guanine (G)).	Guanine	266-273	lysine acetyltransferase 2B	Homo sapiens	183-186
23583737-1	2013	The results of quantum mechanical calculations, including binding energies and results of the population analysis show that the GC and AT base pair complexes are more stable than the CAF-X ones (where CAF is caffeine and X=adenine (A), thymine (T), cytosine (C) and guanine (G)).	Guanine	266-273	lysine acetyltransferase 2B	Homo sapiens	201-204
23583737-2	2013	Structural similarity between the CAF molecule and purine bases (G and A) provides the possibility of incorporation of the CAF molecule into the DNA macromolecule.	purine	51-57	lysine acetyltransferase 2B	Homo sapiens	123-126
23305175-7	2013	Compared with the CAF from low Treg adenocarcinoma, culture supernatant of the CAF from high Treg adenocarcinoma induced more Treg (P = 0.01).	treg	31-35	lysine acetyltransferase 2B	Homo sapiens	79-82
22834763-0	2012	CAF@ZIF-8: one-step encapsulation of caffeine in MOF.	Caffeine	37-45	lysine acetyltransferase 2B	Homo sapiens	0-9
24356308-7	2013	RESULTS: CAF concentrations strongly correlated with creatinine (r = 0.86 (cWP), r = 0.74 (cBP)) and eGFR (MDRD) (r = 0.86 (cWP), r = 0.77 (cBP)).	Creatinine	53-63	lysine acetyltransferase 2B	Homo sapiens	9-12
24356308-10	2013	Stable concentrations were reached 1-3 months after transplantation for CAF and creatinine (CAF 145.1 (6.7-851.0) pM; creatinine 1.6 (0.7-8.0) mg/dl).	Creatinine	80-90	lysine acetyltransferase 2B	Homo sapiens	92-95
24356308-11	2013	CAF concentrations at POD 1-3 were significantly associated with DGF and outperformed creatinine in early detection of DGF (area under the curve (AUC) CAF 80.7% (95% CI 72.3-89.1%) vs. AUC creatinine 71.3% (95% CI 61.8-81.1%), p = 0.061).	Creatinine	189-199	lysine acetyltransferase 2B	Homo sapiens	0-3
22683512-7	2013	It also explores how CAF concentration is influenced by vitamin D supplementation and physical exercise.	Vitamin D	56-65	lysine acetyltransferase 2B	Homo sapiens	21-24
22683512-15	2013	Vitamin D supplementation and physical exercise were significantly associated with a reduction in CAF concentration, especially in participants with initially high CAF concentrations.	Vitamin D	0-9	lysine acetyltransferase 2B	Homo sapiens	98-101
22683512-15	2013	Vitamin D supplementation and physical exercise were significantly associated with a reduction in CAF concentration, especially in participants with initially high CAF concentrations.	Vitamin D	0-9	lysine acetyltransferase 2B	Homo sapiens	164-167
22683512-18	2013	CAF concentration is reduced by vitamin D supplementation and physical exercise and therefore suggests a potentially positive effect on NMJs.	Vitamin D	32-41	lysine acetyltransferase 2B	Homo sapiens	0-3
22985858-5	2012	Pretreatment with histone acetyltransferase (HAT) inhibitor (garcinol and 2-methylene y-butylactone), that inhibits p300, p300/CREB binding protein (CBP) associated factor (PCAF), and GCN 5, prevented the senktide-induced increase in expression of most, but not all, of the genes upregulated in response to 1 nM and 10nM senktide.	garcinol	61-69	lysine acetyltransferase 2B	Homo sapiens	173-177
22985858-5	2012	Pretreatment with histone acetyltransferase (HAT) inhibitor (garcinol and 2-methylene y-butylactone), that inhibits p300, p300/CREB binding protein (CBP) associated factor (PCAF), and GCN 5, prevented the senktide-induced increase in expression of most, but not all, of the genes upregulated in response to 1 nM and 10nM senktide.	2-methylene y-butylactone	74-99	lysine acetyltransferase 2B	Homo sapiens	173-177
22709982-6	2012	Sequencing methods were used to determine the genotype at the Ile997Val and Asn386Ser on EP300 and PCAF.	ile997val	62-71	lysine acetyltransferase 2B	Homo sapiens	99-103
22709982-9	2012	The PCAF Ser/Ser genotype at codon 386 was more frequent in HCC cases than in control group (P=0.03).	Serine	9-12	lysine acetyltransferase 2B	Homo sapiens	4-8
22709982-9	2012	The PCAF Ser/Ser genotype at codon 386 was more frequent in HCC cases than in control group (P=0.03).	Serine	13-16	lysine acetyltransferase 2B	Homo sapiens	4-8
23221385-4	2013	Navitoclax induced apoptosis in CAF and in myofibroblastic human hepatic stellate cells but lacked similar effects in quiescent fibroblasts or cholangiocarcinoma cells.	navitoclax	0-10	lysine acetyltransferase 2B	Homo sapiens	32-35
23128090-0	2012	Inhibition of PCAF histone acetyltransferase, cytotoxicity and cell permeability of 2-acylamino-1-(3- or 4-carboxy-phenyl)benzamides.	2-acylamino-1-(3- or 4-carboxy-phenyl)benzamides	84-132	lysine acetyltransferase 2B	Homo sapiens	14-18
22150271-7	2012	Acetylation assays show that HMGN3a stimulates the ability of PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] to acetylate nucleosomal H3 in vitro, whereas HMGN3b does not.	Cyclic AMP	79-83	lysine acetyltransferase 2B	Homo sapiens	62-66
22547391-5	2012	PCAF associates with p27 through its catalytic domain and acetylates p27 at lysine 100.	Lysine	76-82	lysine acetyltransferase 2B	Homo sapiens	0-4
22547391-7	2012	A p27 mutant in which K100 was substituted by arginine (p27-K100R) cannot be acetylated by PCAF and has a half-life much higher than that of p27WT.	Arginine	46-54	lysine acetyltransferase 2B	Homo sapiens	91-95
22207202-7	2012	Here, we use mutagenesis to show that a lysine residue at position 34 within AD1 of E12/E47 is acetylated by CBP/p300 and PCAF.	Lysine	40-46	lysine acetyltransferase 2B	Homo sapiens	122-126
24832227-8	2012	This improved characterization of Tat.PCAF bromodomain binding may help in defining the structural determinants of other protein interactions involving lysine acetylation.	Lysine	152-158	lysine acetyltransferase 2B	Homo sapiens	38-42
22758906-5	2012	(2) The single-electron reduction potential of CAF(+) is much more negative than that of BNA(+) [E(red) = -1.419 V], which means that CAF(+) is not a good electron acceptor.	2-Naphthylamine	89-92	lysine acetyltransferase 2B	Homo sapiens	134-140
22100137-4	2012	Biochemical assays revealed novel anacardic acid analogs that inhibited the human recombinant enzyme Tip60 selectively compared to PCAF and p300.	anacardic acid	34-48	lysine acetyltransferase 2B	Homo sapiens	131-135
21774670-4	2012	In this report we investigated the role of the additional HAT proteins CREB binding protein (CBP), p300/CBP-associated factor (PCAF), and general control of amino-acid synthesis 5 (GCN5) in regulation of glucose-stimulated insulin gene transcription.	Glucose	204-211	lysine acetyltransferase 2B	Homo sapiens	99-125
21774670-5	2012	Utilizing quantitative chromatin immunoprecipitation analysis, we demonstrate that glucose regulates the binding of p300, CBP, PCAF, and GCN5 to the proximal insulin promoter.	Glucose	83-90	lysine acetyltransferase 2B	Homo sapiens	127-131
21774670-7	2012	These data suggest that high glucose mediates the recruitment of p300, CBP, PCAF, and GCN5 to the insulin promoter and that all four HATs are important for insulin gene expression.	Glucose	29-36	lysine acetyltransferase 2B	Homo sapiens	76-80
21464158-0	2012	A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma.	Sorafenib	75-84	lysine acetyltransferase 2B	Homo sapiens	34-37
21836046-7	2011	Plasma free fatty acids (FFA) were higher (P < 0.05) in CAF than PLA at rest and remained higher (P < 0.05) during exercise.	Fatty Acids, Nonesterified	7-23	lysine acetyltransferase 2B	Homo sapiens	59-62
21881678-3	2011	Varying the position of the fluorine group in the phenylalanine ring confers different effects on the ability of PCAF to acetylate target histone H3 as well as non-histone p53.	Fluorine	28-36	lysine acetyltransferase 2B	Homo sapiens	113-117
21881678-3	2011	Varying the position of the fluorine group in the phenylalanine ring confers different effects on the ability of PCAF to acetylate target histone H3 as well as non-histone p53.	Phenylalanine	50-63	lysine acetyltransferase 2B	Homo sapiens	113-117
21353783-3	2011	Employing the recombinant HAT p300/CBP-associated factor (PCAF) and two different histone substrates for screening, pyridoisothiazolones were identified as inhibitors of human PCAF.	pyridoisothiazolones	116-136	lysine acetyltransferase 2B	Homo sapiens	30-56
21962702-1	2011	High-resolution continuum source molecular absorption of the calcium mono-fluoride molecule CaF in a graphite furnace has been used to determine fluorine in tea after acid digestion, alkaline solubilization and preparation of a conventional aqueous infusion.	Fluorine	145-153	lysine acetyltransferase 2B	Homo sapiens	92-95
21207054-8	2011	Heart rates, plasma lactate, and glucose increased significantly with CRE + CAF during most sprints.	Lactic Acid	20-27	lysine acetyltransferase 2B	Homo sapiens	76-79
21207054-8	2011	Heart rates, plasma lactate, and glucose increased significantly with CRE + CAF during most sprints.	Glucose	33-40	lysine acetyltransferase 2B	Homo sapiens	76-79
21962702-0	2011	Determination of fluorine in tea using high-resolution molecular absorption spectrometry with electrothermal vaporization of the calcium mono-fluoride CaF.	Fluorine	17-25	lysine acetyltransferase 2B	Homo sapiens	151-154
21962702-0	2011	Determination of fluorine in tea using high-resolution molecular absorption spectrometry with electrothermal vaporization of the calcium mono-fluoride CaF.	calcium mono-fluoride	129-150	lysine acetyltransferase 2B	Homo sapiens	151-154
21962702-1	2011	High-resolution continuum source molecular absorption of the calcium mono-fluoride molecule CaF in a graphite furnace has been used to determine fluorine in tea after acid digestion, alkaline solubilization and preparation of a conventional aqueous infusion.	calcium mono-fluoride	61-82	lysine acetyltransferase 2B	Homo sapiens	92-95
21962702-1	2011	High-resolution continuum source molecular absorption of the calcium mono-fluoride molecule CaF in a graphite furnace has been used to determine fluorine in tea after acid digestion, alkaline solubilization and preparation of a conventional aqueous infusion.	Graphite	101-109	lysine acetyltransferase 2B	Homo sapiens	92-95
21962702-2	2011	The strongest absorption "line" of the CaF molecule is at 606.440 nm, which is part of the rotational fine structure of the X(2)Sigma(+)-A(2)Pi electronic transition; it has a bond dissociation energy of 529 kJ mol(-1), which is comparable with other molecules used for fluorine determination.	Fluorine	270-278	lysine acetyltransferase 2B	Homo sapiens	39-42
21618425-3	2011	METHODS AND RESULTS: This study reports by Western-Blot analysis, that peptide lunasin is mainly an in vitro inhibitor of histone H4 acetylation by P300/cAMP-response element-binding protein (CBP)-associated factor (PCAF), with IC50 values dependent on the lysine position sensitive to be acetylated (0.83 muM (H4-Lys 8), 1.27 muM (H4-Lys 12) and 0.40 muM (H4-Lys 5, 8, 12, 16)).	P-300	148-152	lysine acetyltransferase 2B	Homo sapiens	216-220
21353783-3	2011	Employing the recombinant HAT p300/CBP-associated factor (PCAF) and two different histone substrates for screening, pyridoisothiazolones were identified as inhibitors of human PCAF.	pyridoisothiazolones	116-136	lysine acetyltransferase 2B	Homo sapiens	58-62
21353783-3	2011	Employing the recombinant HAT p300/CBP-associated factor (PCAF) and two different histone substrates for screening, pyridoisothiazolones were identified as inhibitors of human PCAF.	pyridoisothiazolones	116-136	lysine acetyltransferase 2B	Homo sapiens	176-180
21416054-1	2011	KLF8 regulates target genes by recruiting the p300 and PCAF co-activators via glutamines (Q) 118 and 248, the CtBP co-repressor to 86PVDLS90 or SUMO to lysine (K) 67.	Glutamine	78-88	lysine acetyltransferase 2B	Homo sapiens	55-59
21282301-6	2011	Garcinol and anacardic acid, inhibitors of the histone acetyl transferases CBP/p300 and PCAF, reduced basal and HDAC inhibitor-induced t-PA expression, whereas curcumin, an inhibitor of CBP/p300 only, had no effect.	garcinol	0-8	lysine acetyltransferase 2B	Homo sapiens	88-92
21282301-6	2011	Garcinol and anacardic acid, inhibitors of the histone acetyl transferases CBP/p300 and PCAF, reduced basal and HDAC inhibitor-induced t-PA expression, whereas curcumin, an inhibitor of CBP/p300 only, had no effect.	anacardic acid	13-27	lysine acetyltransferase 2B	Homo sapiens	88-92
21447625-7	2011	Cooperation of ATP-dependent remodeling, histone methylation, and kinase activation, followed by H1 displacement, is a prerequisite for the subsequent displacement of histone H2A/H2B catalyzed by PCAF and BAF.	Adenosine Triphosphate	15-18	lysine acetyltransferase 2B	Homo sapiens	196-200
21177250-2	2011	We previously demonstrated that a class II histone deacetylase (HDAC), HDAC4, and a histone acetyltransferase, PCAF, associate with cardiac sarcomeres, and a class I and II HDAC inhibitor, trichostatin A, enhances contractile activity of myofilaments.	trichostatin A	189-203	lysine acetyltransferase 2B	Homo sapiens	111-115
21413932-4	2011	RANKL stimulates NFATc1 acetylation via HATs (histone acetyltransferases), such as p300 and PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor], thereby stabilizing NFATc1 proteins.	Cyclic AMP	109-113	lysine acetyltransferase 2B	Homo sapiens	92-96
21267493-2	2011	They show selectivity for inhibition of the thiol-dependent cysteine protease cathepsin B and the histone acetyltransferase p300/CBP associated factor (PCAF) based on their substitution pattern.	Sulfhydryl Compounds	44-49	lysine acetyltransferase 2B	Homo sapiens	152-156
21416054-3	2011	Mass spectrometry and immunoprecipitations determined that p300 and/or PCAF promoted KLF8 acetylation at K67, K93, and K95 and this acetylation was abolished in lysine-to-arginine (R) mutants.	Lysine	161-167	lysine acetyltransferase 2B	Homo sapiens	71-75
21416054-3	2011	Mass spectrometry and immunoprecipitations determined that p300 and/or PCAF promoted KLF8 acetylation at K67, K93, and K95 and this acetylation was abolished in lysine-to-arginine (R) mutants.	Arginine	171-179	lysine acetyltransferase 2B	Homo sapiens	71-75
21416054-7	2011	Promoter reporter assays showed that CtBP inhibited KLF8 transactivity which was rescued by PCAF or p300 expresson.	ctbp	37-41	lysine acetyltransferase 2B	Homo sapiens	92-96
20601085-8	2010	By spot mapping analysis we first identified Lys 117 and 251 as the putative GAPDH residues that could be acetylated by PCAF.	Lysine	45-48	lysine acetyltransferase 2B	Homo sapiens	120-124
21411838-1	2011	CONTEXT: Carbohydrate (CHO) and caffeine (CAF) both improve endurance performance.	Caffeine	32-40	lysine acetyltransferase 2B	Homo sapiens	42-45
21411838-2	2011	PURPOSE: To determine by systematic literature review coupled with meta-analysis whether CAF ingested with CHO (CHO+CAF) improves endurance performance more than CHO alone.	CAV protocol	107-110	lysine acetyltransferase 2B	Homo sapiens	89-92
21411838-2	2011	PURPOSE: To determine by systematic literature review coupled with meta-analysis whether CAF ingested with CHO (CHO+CAF) improves endurance performance more than CHO alone.	CAV protocol	107-110	lysine acetyltransferase 2B	Homo sapiens	112-119
21411838-2	2011	PURPOSE: To determine by systematic literature review coupled with meta-analysis whether CAF ingested with CHO (CHO+CAF) improves endurance performance more than CHO alone.	CAV protocol	112-115	lysine acetyltransferase 2B	Homo sapiens	89-92
21411838-10	2011	To determine whether ES of CHO+CAF vs. CHO was different than CAF compared with water (placebo), a subgroup meta-analysis compared 36 CAF vs. placebo studies against the 21 CHO+CAF vs. CHO studies.	Einsteinium	21-23	lysine acetyltransferase 2B	Homo sapiens	27-34
21411838-13	2011	However, the magnitude of the performance benefit that CAF provides is less when added to CHO than when added to placebo.	CAV protocol	90-93	lysine acetyltransferase 2B	Homo sapiens	55-58
21062767-8	2011	Functional analysis showed that nuclear factors interact in vitro with the oligonucleotides encompassing the -2481G/C polymorphism and that this interaction might be influenced by this polymorphism in the PCAF promoter.	Oligonucleotides	75-91	lysine acetyltransferase 2B	Homo sapiens	205-209
20484412-5	2010	Two switch/sucrose nonfermentable-like complexes, Brahma-related gene 1-associated factor (BAF) and polybromo-BAF are present in breast cancer cells, but only BAF is recruited to the MMTV promoter and cooperates with PCAF during activation of hormone-responsive promoters.	Sucrose	11-18	lysine acetyltransferase 2B	Homo sapiens	217-221
19773423-6	2009	The inhibition is neither competitive with ATP, nor with the substrate histone H1 suggesting that somehow PCAF disturbs cyclin/cdk2 complexes.	Adenosine Triphosphate	43-46	lysine acetyltransferase 2B	Homo sapiens	106-110
20631054-5	2010	Dioxin induced the recruitment of AHR and the transcriptional coactivators p300 and p300/cAMP response element-binding protein binding protein-associated factor (PCAF) to the CYP1B1 enhancer in HepG2 cells but failed to induce recruitment of RNA polymerase II (polII) or the TATA binding protein (TBP) and acetylations of histones 3 and 4 or methylation of histone 3 at the promoter.	Dioxins	0-6	lysine acetyltransferase 2B	Homo sapiens	162-166
20631054-5	2010	Dioxin induced the recruitment of AHR and the transcriptional coactivators p300 and p300/cAMP response element-binding protein binding protein-associated factor (PCAF) to the CYP1B1 enhancer in HepG2 cells but failed to induce recruitment of RNA polymerase II (polII) or the TATA binding protein (TBP) and acetylations of histones 3 and 4 or methylation of histone 3 at the promoter.	Cyclic AMP	89-93	lysine acetyltransferase 2B	Homo sapiens	162-166
20655754-0	2010	Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative.	anacardic acid	64-78	lysine acetyltransferase 2B	Homo sapiens	27-57
20655754-2	2010	The natural product anacardic acid is a starting point for development of small molecule inhibitors of the histone acetyltransferase (HAT) p300/CBP associated factor (PCAF).	anacardic acid	20-34	lysine acetyltransferase 2B	Homo sapiens	167-171
20655754-3	2010	In order to optimize the inhibitory potency, a binding model for PCAF inhibition by anacardic acid was proposed and new anacardic acid derivatives were designed.	anacardic acid	84-98	lysine acetyltransferase 2B	Homo sapiens	65-69
20655754-3	2010	In order to optimize the inhibitory potency, a binding model for PCAF inhibition by anacardic acid was proposed and new anacardic acid derivatives were designed.	anacardic acid	120-134	lysine acetyltransferase 2B	Homo sapiens	65-69
20491776-7	2010	As a result, the cell growth and invasive ability of KK47 cells was retarded by PCAF knockdown, and PCAF knockdown rendered KK47 cells sensitive to cisplatin and doxorubicin, but not to 5-fluorouracil.	Cisplatin	148-157	lysine acetyltransferase 2B	Homo sapiens	100-104
20491776-7	2010	As a result, the cell growth and invasive ability of KK47 cells was retarded by PCAF knockdown, and PCAF knockdown rendered KK47 cells sensitive to cisplatin and doxorubicin, but not to 5-fluorouracil.	Doxorubicin	162-173	lysine acetyltransferase 2B	Homo sapiens	100-104
20144149-7	2010	Histone acetyltransferases such as p300 and P/CAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] increased induction of the MMP28 promoter by Sp1.	Cyclic AMP	62-66	lysine acetyltransferase 2B	Homo sapiens	44-49
19683843-0	2009	Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase.	isothiazolones	14-28	lysine acetyltransferase 2B	Homo sapiens	81-85
19683843-0	2009	Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase.	isothiazolone-1-oxides	33-55	lysine acetyltransferase 2B	Homo sapiens	81-85
19683843-2	2009	The inhibition of the enzyme PCAF and proliferation of the cancer cell line HEP G2 by a series of 5-chloroisothiazolones was compared to a series of 5-chloroisothiazolone-1-oxides.	5-chloroisothiazolones	98-120	lysine acetyltransferase 2B	Homo sapiens	29-33
19683843-3	2009	The PCAF inhibitory potency of 5-chloroisothiazolones and 5-chloroisothiazolone-1-oxides is influenced by substitution in the 4-position.	5-chloroisothiazolones	31-53	lysine acetyltransferase 2B	Homo sapiens	4-8
19683843-3	2009	The PCAF inhibitory potency of 5-chloroisothiazolones and 5-chloroisothiazolone-1-oxides is influenced by substitution in the 4-position.	5-chloroisothiazolone-1-oxides	58-88	lysine acetyltransferase 2B	Homo sapiens	4-8
20491776-3	2010	We found that PCAF, Twist1, and Y-box binding protein-1 (YB-1) expressions were elevated in cisplatin- and doxorubicin-resistant cancer cells.	Cisplatin	92-101	lysine acetyltransferase 2B	Homo sapiens	14-18
20491776-3	2010	We found that PCAF, Twist1, and Y-box binding protein-1 (YB-1) expressions were elevated in cisplatin- and doxorubicin-resistant cancer cells.	Doxorubicin	107-118	lysine acetyltransferase 2B	Homo sapiens	14-18
20821592-6	2010	Two factors--the anionic accumulation factor (AAF) and the cellular affinity factor (CAF)--determine the effective concentration of an SA.	Sulfonamides	135-137	lysine acetyltransferase 2B	Homo sapiens	59-91
20821592-8	2010	The CAF subsumes relevant cellular and enzyme properties, and is directly proportional to the DHPS affinity constant for an SA.	Sulfonamides	124-126	lysine acetyltransferase 2B	Homo sapiens	4-7
20821592-10	2010	The derived dose-response relationship explains the pH and pKa dependency of mean effective concentration values (EC50) of eight SA and two soil bacteria based on AAF and CAF values.	Sulfonamides	129-131	lysine acetyltransferase 2B	Homo sapiens	171-174
20821592-11	2010	The mathematical model can be used to extrapolate sulfonamide effects to other pH values and to calculate the CAF as a pH-independent measure for the SA effects on microbial growth.	Sulfonamides	150-152	lysine acetyltransferase 2B	Homo sapiens	110-113
20363750-9	2010	Thus, acetylation of EVI1 at Lys(564) by P/CAF enhances the DNA binding capacity of EVI1 and thereby contributes to the activation of GATA2.	Lysine	29-32	lysine acetyltransferase 2B	Homo sapiens	41-46
20213728-0	2010	CARM1 activates myogenin gene via PCAF in the early differentiation of TPA-induced rhabdomyosarcoma-derived cells.	Tetradecanoylphorbol Acetate	71-74	lysine acetyltransferase 2B	Homo sapiens	34-38
20213728-3	2010	Here, we show that CARM1 can be recruited to the promoter of myogenin gene to enhance its transcriptional activation via PCAF at the early stage of TPA-induced RD cell differentiation.	Tetradecanoylphorbol Acetate	148-151	lysine acetyltransferase 2B	Homo sapiens	121-125
20213728-4	2010	By adding adenosine dialdehyde, AdOx, to inhibit the PRMT in RD cells, the TPA-induced recruiting of p300, PCAF and the Brg1 at the myogenin promoter is abolished and myogenic differentiation is blocked.	periodate-oxidized adenosine	10-30	lysine acetyltransferase 2B	Homo sapiens	107-111
20213728-4	2010	By adding adenosine dialdehyde, AdOx, to inhibit the PRMT in RD cells, the TPA-induced recruiting of p300, PCAF and the Brg1 at the myogenin promoter is abolished and myogenic differentiation is blocked.	periodate-oxidized adenosine	32-36	lysine acetyltransferase 2B	Homo sapiens	107-111
20213728-4	2010	By adding adenosine dialdehyde, AdOx, to inhibit the PRMT in RD cells, the TPA-induced recruiting of p300, PCAF and the Brg1 at the myogenin promoter is abolished and myogenic differentiation is blocked.	Tetradecanoylphorbol Acetate	75-78	lysine acetyltransferase 2B	Homo sapiens	107-111
20213728-6	2010	We suggest that the physical interaction of CARM1 and PCAF is likely pivotal for the activation of PCAF in the downstream of CARM1 pathway for inducing myogenin under TPA-induced differentiation.	Tetradecanoylphorbol Acetate	167-170	lysine acetyltransferase 2B	Homo sapiens	54-58
20213728-6	2010	We suggest that the physical interaction of CARM1 and PCAF is likely pivotal for the activation of PCAF in the downstream of CARM1 pathway for inducing myogenin under TPA-induced differentiation.	Tetradecanoylphorbol Acetate	167-170	lysine acetyltransferase 2B	Homo sapiens	99-103
20352046-10	2010	Of note, cAMP recruited pCREB, CBP/p300, and PCAF to the promoter whereas T(3) caused dissociation of NCoR/SMRT and HDAC3.	Cyclic AMP	9-13	lysine acetyltransferase 2B	Homo sapiens	45-49
19773423-9	2009	Moreover, we also observed that PCAF acetylates cdk2 at lysine 33.	Lysine	56-62	lysine acetyltransferase 2B	Homo sapiens	32-36
19146394-4	2009	Methoxycoumarin (Mca) is conjugated to HAT substrate analogues to function as fluorescent donors, namely, H3CoA20Mca for interacting with PCAF and LysCoAMca for p300.	3-methoxychromen-2-one	0-15	lysine acetyltransferase 2B	Homo sapiens	138-142
20087429-8	2009	The acetyltransferase PCAF is also required for induction of progesterone target genes and acetylates histone H3 at K14, an epigenetic mark, which interacts with Brg1 and Brm, anchoring the BAF complex to chromatin.	Progesterone	61-73	lysine acetyltransferase 2B	Homo sapiens	22-26
19483727-2	2009	Here, we report that the acetyltransferase P/CAF directly interacts with cyclin A that as a consequence becomes acetylated at lysines 54, 68, 95 and 112.	Lysine	126-133	lysine acetyltransferase 2B	Homo sapiens	25-48
19351588-0	2009	Multiple lysine methylation of PCAF by Set9 methyltransferase.	Lysine	9-15	lysine acetyltransferase 2B	Homo sapiens	31-35
19351588-6	2009	Further methyltransferase assays focusing on the six lysine residues showed that K78 and K89 are preferentially methylated in full-length PCAF in vitro.	Lysine	53-59	lysine acetyltransferase 2B	Homo sapiens	138-142
19522704-5	2009	Furthermore, we found that this repression could be relieved by P/CAF (p300/CBP-associated factor) in a dose-dependent manner, but not by CBP [CREB (cAMP-response-element-binding protein)-binding protein].	Cyclic AMP	149-153	lysine acetyltransferase 2B	Homo sapiens	64-69
19522704-5	2009	Furthermore, we found that this repression could be relieved by P/CAF (p300/CBP-associated factor) in a dose-dependent manner, but not by CBP [CREB (cAMP-response-element-binding protein)-binding protein].	Cyclic AMP	149-153	lysine acetyltransferase 2B	Homo sapiens	71-97
18709356-2	2009	We found that the ethanol extract from wild fruiting bodies of Antrodia camphorata (EEAC) could induce HL 60 cells apoptosis via histone hypoacetylation, up-regulation of histone deacetyltransferase 1 (HDAC 1), and down-regulation of histone acetyltransferase activities including GCN 5, CBP and PCAF in dose-dependent manner.	Ethanol	18-25	lysine acetyltransferase 2B	Homo sapiens	296-300
18709356-2	2009	We found that the ethanol extract from wild fruiting bodies of Antrodia camphorata (EEAC) could induce HL 60 cells apoptosis via histone hypoacetylation, up-regulation of histone deacetyltransferase 1 (HDAC 1), and down-regulation of histone acetyltransferase activities including GCN 5, CBP and PCAF in dose-dependent manner.	eeac	84-88	lysine acetyltransferase 2B	Homo sapiens	296-300
19146394-4	2009	Methoxycoumarin (Mca) is conjugated to HAT substrate analogues to function as fluorescent donors, namely, H3CoA20Mca for interacting with PCAF and LysCoAMca for p300.	mca	17-20	lysine acetyltransferase 2B	Homo sapiens	138-142
19146394-4	2009	Methoxycoumarin (Mca) is conjugated to HAT substrate analogues to function as fluorescent donors, namely, H3CoA20Mca for interacting with PCAF and LysCoAMca for p300.	h3coa20mca	106-116	lysine acetyltransferase 2B	Homo sapiens	138-142
19015268-4	2009	Intramolecular acetylation targets five lysines within the nuclear localization signal at the P/CAF C terminus.	Lysine	40-47	lysine acetyltransferase 2B	Homo sapiens	94-99
18574470-6	2008	As the K320 p53 acetylation is the site predominantly affected in hypoxia, the PCAF histone acetyltransferase activity is the key regulator of the cellular fate modulated by p53 under these conditions.	5-Bromo-2-fluoropyridine	7-11	lysine acetyltransferase 2B	Homo sapiens	79-83
19111471-0	2009	Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones.	isothiazolones	76-90	lysine acetyltransferase 2B	Homo sapiens	18-22
19111471-2	2009	We present a systematic investigation of the inhibition of the HAT p300/CBP Associated Factor (PCAF) by isothiazolones with different substitutions.	isothiazolones	104-118	lysine acetyltransferase 2B	Homo sapiens	67-93
19111471-2	2009	We present a systematic investigation of the inhibition of the HAT p300/CBP Associated Factor (PCAF) by isothiazolones with different substitutions.	isothiazolones	104-118	lysine acetyltransferase 2B	Homo sapiens	95-99
19111471-3	2009	5-chloroisothiazolones proved to be the most potent inhibitors of PCAF.	5-chloroisothiazolones	0-22	lysine acetyltransferase 2B	Homo sapiens	66-70
19111471-5	2009	Furthermore, the 5-chloroisothiazolone preservative Kathon CG that is used in cosmetics inhibited PCAF and the growth of cell lines A2780 and HEK 293, which indicates that this preservative should be applied with care.	5-chloroisothiazolone	17-38	lysine acetyltransferase 2B	Homo sapiens	98-102
19111471-5	2009	Furthermore, the 5-chloroisothiazolone preservative Kathon CG that is used in cosmetics inhibited PCAF and the growth of cell lines A2780 and HEK 293, which indicates that this preservative should be applied with care.	2-n-octyl-4-isothiazolin-3-one	52-58	lysine acetyltransferase 2B	Homo sapiens	98-102
18458534-6	2008	The CAF gene signature is also predictive of poor clinical outcome in breast cancer patients that were treated with tamoxifen mono-therapy, indicating that CAFs may be useful for predicting the response to hormonal therapy.	Tamoxifen	116-125	lysine acetyltransferase 2B	Homo sapiens	4-7
18710935-7	2008	Finally, disruption of the actin-hnRNP U interaction repressed bromouridine triphosphate incorporation in living cells, suggesting that actin and hnRNP U cooperate with PCAF in the regulation of pol II transcription elongation.	bromouridine triphosphate	63-88	lysine acetyltransferase 2B	Homo sapiens	169-173
18400184-4	2008	Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4.	Lysine	247-254	lysine acetyltransferase 2B	Homo sapiens	153-179
18425496-2	2008	Normally, these factors are transiently activated by specific external signals which induce their dissociation from inhibitors of kappaB (IkappaB) and subsequent translocation to the nucleus where p65 links to the cyclic adenosine monophosphate response element binding protein (CBP)-p300 and P/CAF coactivators that are essential for its transcriptional activity.	Cyclic AMP	214-244	lysine acetyltransferase 2B	Homo sapiens	293-298
18443043-5	2008	CREB binding protein (CBP) and p300/CBP-associated factor (PCAF) were displaced from transcription factor binding sites on the MMP-9 promoter within minutes of RA treatment.	Tretinoin	160-162	lysine acetyltransferase 2B	Homo sapiens	31-57
18443043-5	2008	CREB binding protein (CBP) and p300/CBP-associated factor (PCAF) were displaced from transcription factor binding sites on the MMP-9 promoter within minutes of RA treatment.	Tretinoin	160-162	lysine acetyltransferase 2B	Homo sapiens	59-63
18250157-3	2008	Here we show that cellular GCN5 and P/CAF, members of the GCN5-related N-acetyltransferase family of histone acetyltransferases, regulate CDK9 function by specifically acetylating the catalytic core of the enzyme and, in particular, a lysine that is essential for ATP coordination and the phosphotransfer reaction.	Adenosine Triphosphate	264-267	lysine acetyltransferase 2B	Homo sapiens	36-41
18377363-7	2008	Several subunits of the P/CAF {p300/CBP [CREB (cAMP-response-element-binding protein)-binding protein]-associated factor} complex, including ADA3, ADA2alpha/beta and P/CAF, showed co-localization with ANCO-1 nuclear dots, indicating an in vivo association of ANCO-1 with the P/CAF complex.	Cyclic AMP	47-51	lysine acetyltransferase 2B	Homo sapiens	24-29
18533195-2	2008	In this paper, the optimal controller represents the optimal drug dosage of CAF (Cyclophosphamide, Adriamycin and Fluorouracil) regimen in adjuvant chemotherapy after surgery for these patients.	Cyclophosphamide	81-97	lysine acetyltransferase 2B	Homo sapiens	76-79
18533195-2	2008	In this paper, the optimal controller represents the optimal drug dosage of CAF (Cyclophosphamide, Adriamycin and Fluorouracil) regimen in adjuvant chemotherapy after surgery for these patients.	Doxorubicin	99-109	lysine acetyltransferase 2B	Homo sapiens	76-79
18533195-2	2008	In this paper, the optimal controller represents the optimal drug dosage of CAF (Cyclophosphamide, Adriamycin and Fluorouracil) regimen in adjuvant chemotherapy after surgery for these patients.	Fluorouracil	114-126	lysine acetyltransferase 2B	Homo sapiens	76-79
18250157-3	2008	Here we show that cellular GCN5 and P/CAF, members of the GCN5-related N-acetyltransferase family of histone acetyltransferases, regulate CDK9 function by specifically acetylating the catalytic core of the enzyme and, in particular, a lysine that is essential for ATP coordination and the phosphotransfer reaction.	Lysine	235-241	lysine acetyltransferase 2B	Homo sapiens	36-41
18400184-4	2008	Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4.	Lysine	247-254	lysine acetyltransferase 2B	Homo sapiens	181-185
18400184-4	2008	Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4.	Lysine	247-253	lysine acetyltransferase 2B	Homo sapiens	153-179
18400184-4	2008	Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4.	Lysine	247-253	lysine acetyltransferase 2B	Homo sapiens	181-185
18089905-3	2007	Each participant received the caffeinated (5 mg/kg) drink (CAF) and placebo (PL) twice each on 4 separate days.	caffeinated	30-41	lysine acetyltransferase 2B	Homo sapiens	59-62
18266548-4	2008	This study compared the effects of a caffeine-containing (200 mg) supplement (CAF) or placebo in capsule form after prolonged wakefulness, in participants who varied in their level of habitual caffeine use.	Caffeine	37-45	lysine acetyltransferase 2B	Homo sapiens	78-81
18306618-0	2007	[Relationship between Ca, P and F concentration of plaque residues in the primary teeth and caries status, sugar exposure frequency].	Sugars	107-112	lysine acetyltransferase 2B	Homo sapiens	22-33
18306618-1	2007	OBJECTIVE: To analyze the relationship between inorganic ingredients (Ca, P and F) concentration of plaque residues in the primary teeth and caries status, sugar exposure frequency.	Sugars	156-161	lysine acetyltransferase 2B	Homo sapiens	70-81
18306618-5	2007	Ca, P and F concentration of plaque residues was measured by atomic absorption spectroscopy, spectrophotometer and fluoride electrode respectively.	Fluorides	115-123	lysine acetyltransferase 2B	Homo sapiens	0-11
17999329-6	2008	A three-way mixed effects linear model with ensemble by metabolic rate category interactions demonstrated that the CAF did not change with metabolic rate, so CAFs can be used over a wide range of metabolic rates.	cafs	158-162	lysine acetyltransferase 2B	Homo sapiens	115-118
17884818-5	2007	An in vivo acetylation assay using 293T cells revealed that Fli1 is mainly acetylated by the histone acetyltransferase activity of p300/CBP-associated factor (PCAF) at lysine 380.	Lysine	168-174	lysine acetyltransferase 2B	Homo sapiens	131-157
17884818-5	2007	An in vivo acetylation assay using 293T cells revealed that Fli1 is mainly acetylated by the histone acetyltransferase activity of p300/CBP-associated factor (PCAF) at lysine 380.	Lysine	168-174	lysine acetyltransferase 2B	Homo sapiens	159-163
17884818-11	2007	These results indicate that PCAF-dependent acetylation of lysine 380 abrogates repressor function of Fli1 with respect to collagen gene expression.	Lysine	58-64	lysine acetyltransferase 2B	Homo sapiens	28-32
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	24-30	lysine acetyltransferase 2B	Homo sapiens	138-142
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	57-60	lysine acetyltransferase 2B	Homo sapiens	138-142
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	lysine acetyltransferase 2B	Homo sapiens	138-142
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	lysine acetyltransferase 2B	Homo sapiens	138-142
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	lysine acetyltransferase 2B	Homo sapiens	138-142
17627840-3	2007	It turned out that five lysine residues in HMGA1a, i.e., Lys-14, Lys-64, Lys-66, Lys-70, and Lys-73, could be acetylated by both p300 and PCAF.	Lysine	65-68	lysine acetyltransferase 2B	Homo sapiens	138-142
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	166-169	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	166-169	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	266-270
17627840-5	2007	Quantification results revealed that p300 and PCAF exhibited different site preferences for the acetylation; the preference of p300 acetylation followed the order of Lys-64 approximately Lys-70 > Lys-66 > Lys-14 approximately Lys73, whereas the selectivity of PCAF acetylation followed the sequence of Lys-70 approximately Lys-73 > Lys-64 approximately Lys-66 > Lys-14.	Lysine	187-190	lysine acetyltransferase 2B	Homo sapiens	46-50
17667922-8	2007	Trichostatin A treatment did not modify MBD1 binding to the ABCB1 promoter and similarly increased PCAF binding in both H69 cell lines.	trichostatin A	0-14	lysine acetyltransferase 2B	Homo sapiens	99-103
17805088-3	2007	Sixty minutes before exercise, participants ingested 6 mg.kg(-1) body mass of caffeine (CAF) or placebo (PLA), then during exercise they consumed a 6% CHO or placebo (PLA) drink, providing CAF/CHO, PLA/CHO, CAF/PLA, and PLA/PLA conditions.	Caffeine	78-86	lysine acetyltransferase 2B	Homo sapiens	88-91
17805088-7	2007	Coingestion of CAF/CHO significantly attenuated epinephrine (P<0.05) and IL-6 (P<0.05) responses that occurred after ingestion of CAF alone (CAF/PLA) and significantly attenuated the transient alterations in circulating leukocyte (P<0.05) and neutrophil (P<0.01) counts.	cho	19-22	lysine acetyltransferase 2B	Homo sapiens	136-139
17805088-7	2007	Coingestion of CAF/CHO significantly attenuated epinephrine (P<0.05) and IL-6 (P<0.05) responses that occurred after ingestion of CAF alone (CAF/PLA) and significantly attenuated the transient alterations in circulating leukocyte (P<0.05) and neutrophil (P<0.01) counts.	cho	19-22	lysine acetyltransferase 2B	Homo sapiens	147-154
17805088-7	2007	Coingestion of CAF/CHO significantly attenuated epinephrine (P<0.05) and IL-6 (P<0.05) responses that occurred after ingestion of CAF alone (CAF/PLA) and significantly attenuated the transient alterations in circulating leukocyte (P<0.05) and neutrophil (P<0.01) counts.	Epinephrine	48-59	lysine acetyltransferase 2B	Homo sapiens	15-18
17805088-8	2007	Plasma cortisol concentration was significantly lower on PLA/CHO than CAF/PLA and PLA/PLA after exercise (P<0.05).	Hydrocortisone	7-15	lysine acetyltransferase 2B	Homo sapiens	70-77
17569822-4	2007	In comparison with K562 cells, the imatinib-resistant variants showed up-regulation of HDAC1, -2, and -3 (class I HDACs) and class III SIRT1 and down-regulation of CBP/p300 and PCAF with HAT activity, and thereby p53 and cytoplasmic Ku70 were aberrantly acetylated.	Imatinib Mesylate	35-43	lysine acetyltransferase 2B	Homo sapiens	177-181
17342336-3	2007	Neoadjuvant chemotherapy comprised two to four cycles of adriamycin-based CAF regimen.	Doxorubicin	57-67	lysine acetyltransferase 2B	Homo sapiens	74-77
17064785-6	2007	Incidences of well- and non-developed PM were significantly less and more in CAF group, respectively.	pipermethystine	38-40	lysine acetyltransferase 2B	Homo sapiens	77-80
17468105-0	2007	Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells.	Tetradecanoylphorbol Acetate	78-114	lysine acetyltransferase 2B	Homo sapiens	26-30
17468105-8	2007	We propose that there are two distinct activation steps for the induction of myogenin in TPA-induced early differentiation of RD cells: 1) an early step that requires PCAF activity to acetylate core histones and MyoD to initiate myogenin gene expression, and 2) a later step that requires p38-dependent activity of the SWI/SNF remodeling complex to provide an open conformation for the induction of myogenin.	Tetradecanoylphorbol Acetate	89-92	lysine acetyltransferase 2B	Homo sapiens	167-171
17496784-3	2007	The NF-kappaB activation appears to result from the enhancer formation including NF-kappaB and lysine acetyl transferases such as p300, CREB (cyclic AMP-responsive element binding protein)-binding protein (CBP), and/or p300/CBP associating factor (PCAF).	Cyclic AMP	142-152	lysine acetyltransferase 2B	Homo sapiens	219-246
17496784-3	2007	The NF-kappaB activation appears to result from the enhancer formation including NF-kappaB and lysine acetyl transferases such as p300, CREB (cyclic AMP-responsive element binding protein)-binding protein (CBP), and/or p300/CBP associating factor (PCAF).	Cyclic AMP	142-152	lysine acetyltransferase 2B	Homo sapiens	248-252
17261755-8	2006	Msk1 phosphorylates H3 at serine 10, which is followed by acetylation at lysine 14, displacement of HP1gamma, and recruitment of Brg1, PCAF, and RNA polymerase II.	Serine	26-32	lysine acetyltransferase 2B	Homo sapiens	135-139
17628895-7	2007	Such modifications can be triggered by steroid hormones in cooperation with coactivators(p160 family proteins, CBP, p300, p/CAF) and/or corepressors (N-Cor, SMRT, TZF).	Steroids	39-46	lysine acetyltransferase 2B	Homo sapiens	122-127
17389641-6	2007	RA induces the recruitment of histone acetyl transferase-containing/GRIP1/p300/CBP-associated factor (PCAF) complex to the TR2 promoter in undifferentiated cells, whereas it triggers recruitment of histone deacetylase-containing/GRIP1/receptor-interacting protein 140 (RIP140) complex in differentiated cells.	Tretinoin	0-2	lysine acetyltransferase 2B	Homo sapiens	74-100
17389641-6	2007	RA induces the recruitment of histone acetyl transferase-containing/GRIP1/p300/CBP-associated factor (PCAF) complex to the TR2 promoter in undifferentiated cells, whereas it triggers recruitment of histone deacetylase-containing/GRIP1/receptor-interacting protein 140 (RIP140) complex in differentiated cells.	Tretinoin	0-2	lysine acetyltransferase 2B	Homo sapiens	102-106
17301242-4	2007	Here, we show that C/EBPbeta is acetylated by GCN5 and PCAF within a cluster of lysine residues between amino acids 98-102 and that this acetylation is strongly induced by glucocorticoid treatment.	Lysine	80-86	lysine acetyltransferase 2B	Homo sapiens	55-59
17033231-1	2006	We performed a controlled study to compare the response to cyclophosphamide (CPA), adriamycin (ADM), and fluorouracil (5-FU) (CAF therapy) with that to uracil-tegafur (UFT) plus tamoxifen (TAM) (UFT+TAM therapy), when given as postoperative adjuvant therapy to women with breast cancer.	Fluorouracil	105-117	lysine acetyltransferase 2B	Homo sapiens	126-129
16887930-8	2006	Dephosphorylation of its AF-1 made TR4 an activator due to its selective recruitment of coactivator, P300/cyclic AMP-responsive element binding protein-binding protein-associated factor (PCAF).	Cyclic AMP	106-116	lysine acetyltransferase 2B	Homo sapiens	187-191
17033231-1	2006	We performed a controlled study to compare the response to cyclophosphamide (CPA), adriamycin (ADM), and fluorouracil (5-FU) (CAF therapy) with that to uracil-tegafur (UFT) plus tamoxifen (TAM) (UFT+TAM therapy), when given as postoperative adjuvant therapy to women with breast cancer.	Fluorouracil	119-123	lysine acetyltransferase 2B	Homo sapiens	126-129
17033231-5	2006	CAF therapy consisted of CPA (100 mg/day) on days 1 to 14, followed by 2 weeks of rest, plus ADM (20 mg/m(2)/day) on days 1 and 8 and 5-FU (300 mg/m(2)/day) on days 1 and 8.	Cyclophosphamide	25-28	lysine acetyltransferase 2B	Homo sapiens	0-3
16362936-4	2006	In particular, tyrosines 760 and 761 of P/CAF, two residues that are highly conserved in most known bromodomains, play an essential role for the binding.	Tyrosine	15-24	lysine acetyltransferase 2B	Homo sapiens	40-45
16759123-3	2006	The Ca* + CH3F --> CaF + CH3 reaction was photoinduced in 1:1 Ca...CH3F complexes formed in a supersonic expansion.	fluoromethane	10-14	lysine acetyltransferase 2B	Homo sapiens	22-25
16547255-3	2006	Strikingly, we show that this repression is due to a tryptophan at residue 32 of Tat E and is secondary to interference with recruitment of the histone acetyltransferase P/CAF to the TNF promoter and with chromatin remodeling of the TNF locus.	Tryptophan	53-63	lysine acetyltransferase 2B	Homo sapiens	170-175
16362936-5	2006	Fluorescence resonance energy transfer (FRET) experiments performed in this work demonstrate that P/CAF proteins in which these tyrosines are mutated into hydrophilic residues neither bind to Tat inside the cells nor mediate Tat transactivation.	Tyrosine	128-137	lysine acetyltransferase 2B	Homo sapiens	98-103
16317770-4	2006	Ser-185 was required for DNA binding, whereas both Ser-170 and Ser-185 were necessary for receptor interaction with P/CAF.	Serine	51-54	lysine acetyltransferase 2B	Homo sapiens	116-121
16317770-4	2006	Ser-185 was required for DNA binding, whereas both Ser-170 and Ser-185 were necessary for receptor interaction with P/CAF.	Serine	51-54	lysine acetyltransferase 2B	Homo sapiens	116-121
16191117-2	2005	In this study, we introduce a novel concept of map, based on the analysis of the wave morphology, which gives a direct evidence in the human right atrium on the spatiotemporal distribution of fibrillatory wave complexity in paroxysmal (PAF) and chronic (CAF) atrial fibrillation.	Platelet Activating Factor	236-239	lysine acetyltransferase 2B	Homo sapiens	254-257
16050810-12	2005	CBP and PCAF occupancy of the proximal ERK1 promoter was dramatically decreased by RA treatment.	Tretinoin	83-85	lysine acetyltransferase 2B	Homo sapiens	8-12
16332025-1	2005	A variety of theoretical procedures, including the high-level ab initio methods G3, G3[CC](dir,full), and W2C//ACQ, have been used to predict the structures and heats of formation of several small calcium-containing molecules (CaH, CaH2, CaO, CaOH, Ca(OH)2, CaF, CaF2, CaS, CaCl, and CaCl2).	Calcium	197-204	lysine acetyltransferase 2B	Homo sapiens	258-261
15919754-11	2005	Stimulation of NIS promoter activity was also obtained by overexpressing histone acetylating proteins pCAF and p300 in HeLa cells.	Nickel	15-18	lysine acetyltransferase 2B	Homo sapiens	102-106
16227401-0	2005	Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity.	isothiazolones	0-14	lysine acetyltransferase 2B	Homo sapiens	32-36
16227401-6	2005	Thirty-five N-substituted analogues inhibited both p300/cyclic AMP-responsive element binding protein-binding protein-associated factor (PCAF) and p300 (1 to >50 micromol/L, respectively) and the growth of a panel of human tumor cell lines (50% growth inhibition, 0.8 to >50 micromol/L).	Nitrogen	12-13	lysine acetyltransferase 2B	Homo sapiens	137-141
16227401-6	2005	Thirty-five N-substituted analogues inhibited both p300/cyclic AMP-responsive element binding protein-binding protein-associated factor (PCAF) and p300 (1 to >50 micromol/L, respectively) and the growth of a panel of human tumor cell lines (50% growth inhibition, 0.8 to >50 micromol/L).	Cyclic AMP	56-66	lysine acetyltransferase 2B	Homo sapiens	137-141
16060659-3	2005	Here, the conformation and dynamics of this PCAF/GCN5 alpha5-beta6 loop was investigated in solution using tryptophan fluorescence.	Tryptophan	107-117	lysine acetyltransferase 2B	Homo sapiens	44-48
16135803-6	2005	Association of p73 with Tat prevented the acetylation of Tat on lysine 28 by PCAF.	Lysine	64-70	lysine acetyltransferase 2B	Homo sapiens	77-81
16060659-4	2005	A mutant human PCAF HAT domain (PCAF(Wloop)) was created in which the natural tryptophan (Trp-514) remote from the alpha5-beta6 loop was replaced with tyrosine and a glutamate within the loop (Glu-641) was substituted with tryptophan.	Tryptophan	78-88	lysine acetyltransferase 2B	Homo sapiens	15-19
16060659-4	2005	A mutant human PCAF HAT domain (PCAF(Wloop)) was created in which the natural tryptophan (Trp-514) remote from the alpha5-beta6 loop was replaced with tyrosine and a glutamate within the loop (Glu-641) was substituted with tryptophan.	Tryptophan	78-88	lysine acetyltransferase 2B	Homo sapiens	32-36
16060659-4	2005	A mutant human PCAF HAT domain (PCAF(Wloop)) was created in which the natural tryptophan (Trp-514) remote from the alpha5-beta6 loop was replaced with tyrosine and a glutamate within the loop (Glu-641) was substituted with tryptophan.	Tryptophan	90-93	lysine acetyltransferase 2B	Homo sapiens	15-19
16060659-4	2005	A mutant human PCAF HAT domain (PCAF(Wloop)) was created in which the natural tryptophan (Trp-514) remote from the alpha5-beta6 loop was replaced with tyrosine and a glutamate within the loop (Glu-641) was substituted with tryptophan.	Tryptophan	90-93	lysine acetyltransferase 2B	Homo sapiens	32-36
16060659-4	2005	A mutant human PCAF HAT domain (PCAF(Wloop)) was created in which the natural tryptophan (Trp-514) remote from the alpha5-beta6 loop was replaced with tyrosine and a glutamate within the loop (Glu-641) was substituted with tryptophan.	Tyrosine	151-159	lysine acetyltransferase 2B	Homo sapiens	15-19
16060659-4	2005	A mutant human PCAF HAT domain (PCAF(Wloop)) was created in which the natural tryptophan (Trp-514) remote from the alpha5-beta6 loop was replaced with tyrosine and a glutamate within the loop (Glu-641) was substituted with tryptophan.	Tyrosine	151-159	lysine acetyltransferase 2B	Homo sapiens	32-36
16060659-4	2005	A mutant human PCAF HAT domain (PCAF(Wloop)) was created in which the natural tryptophan (Trp-514) remote from the alpha5-beta6 loop was replaced with tyrosine and a glutamate within the loop (Glu-641) was substituted with tryptophan.	Glutamic Acid	166-175	lysine acetyltransferase 2B	Homo sapiens	15-19
16060659-4	2005	A mutant human PCAF HAT domain (PCAF(Wloop)) was created in which the natural tryptophan (Trp-514) remote from the alpha5-beta6 loop was replaced with tyrosine and a glutamate within the loop (Glu-641) was substituted with tryptophan.	Glutamic Acid	166-175	lysine acetyltransferase 2B	Homo sapiens	32-36
16060659-4	2005	A mutant human PCAF HAT domain (PCAF(Wloop)) was created in which the natural tryptophan (Trp-514) remote from the alpha5-beta6 loop was replaced with tyrosine and a glutamate within the loop (Glu-641) was substituted with tryptophan.	Glutamic Acid	193-196	lysine acetyltransferase 2B	Homo sapiens	15-19
16060659-4	2005	A mutant human PCAF HAT domain (PCAF(Wloop)) was created in which the natural tryptophan (Trp-514) remote from the alpha5-beta6 loop was replaced with tyrosine and a glutamate within the loop (Glu-641) was substituted with tryptophan.	Glutamic Acid	193-196	lysine acetyltransferase 2B	Homo sapiens	32-36
16060659-4	2005	A mutant human PCAF HAT domain (PCAF(Wloop)) was created in which the natural tryptophan (Trp-514) remote from the alpha5-beta6 loop was replaced with tyrosine and a glutamate within the loop (Glu-641) was substituted with tryptophan.	Tryptophan	223-233	lysine acetyltransferase 2B	Homo sapiens	15-19
16060659-4	2005	A mutant human PCAF HAT domain (PCAF(Wloop)) was created in which the natural tryptophan (Trp-514) remote from the alpha5-beta6 loop was replaced with tyrosine and a glutamate within the loop (Glu-641) was substituted with tryptophan.	Tryptophan	223-233	lysine acetyltransferase 2B	Homo sapiens	32-36
16060659-6	2005	While saturating CoASH induced a 30% quenching of Trp fluorescence in PCAF(Wloop), binding of the high-affinity bisubstrate analogue H3-CoA-20 led to a 2-fold fluorescence increase.	Tryptophan	50-53	lysine acetyltransferase 2B	Homo sapiens	70-74
16153448-11	2005	RESULTS: SAHA-activated NF-kappaB (P <or= .05) and gemcitabine inhibited these effects (P <or= .01).	gemcitabine	54-65	lysine acetyltransferase 2B	Homo sapiens	91-92
15914944-7	2005	The Kaplan-Meier curve for the time to occurrence of CAF showed a lower incidence of CAF in the ACEI group and demonstrated that the 5-year probability for persistence of PAF without progression to CAF was 88.3%, but 47.5% in the non-ACEI group.	Platelet Activating Factor	171-174	lysine acetyltransferase 2B	Homo sapiens	53-56
15918711-0	2005	Quantum defect theory of dipole and vibronic mixing in Rydberg states of CaF.	dipole	25-31	lysine acetyltransferase 2B	Homo sapiens	73-76
15918711-1	2005	The Rydberg spectra of CaF combine the simplicity of a single electron outside a doubly closed-shell Ca2+F- ion core with the exceptional polarity of the ion core.	ca2+f	101-106	lysine acetyltransferase 2B	Homo sapiens	23-26
15647279-0	2005	Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex.	trichostatin A	0-14	lysine acetyltransferase 2B	Homo sapiens	131-135
15918571-5	2005	Generally, 3 cycles of CAF (CEF) therapy induced severe alopecia (grade 3).	cef	28-31	lysine acetyltransferase 2B	Homo sapiens	23-26
15903915-0	2005	Zeeman relaxation of CaF in low-temperature collisions with helium.	Helium	60-66	lysine acetyltransferase 2B	Homo sapiens	21-24
15647279-4	2005	Treatment of cells with TSA activates the TbetaRII promoter in a time-dependent manner through the recruitment of p300 and PCAF into a Sp1.NF-Y.HDAC complex that binds this DNA element.	trichostatin A	24-27	lysine acetyltransferase 2B	Homo sapiens	123-127
15647279-6	2005	Transient overexpression of p300 or PCAF potentiated TSA-induced TbetaRII promoter activity.	trichostatin A	53-56	lysine acetyltransferase 2B	Homo sapiens	36-40
15647279-9	2005	Taken together, these results showed that TSA treatment of pancreatic cancer cells leads to transcriptional activation of the TbetaRII promoter through modulation of the components of a Sp1.NF-Y.p300.PCAF.HDAC-1 multiprotein complex.	trichostatin A	42-45	lysine acetyltransferase 2B	Homo sapiens	200-204
15724976-3	2005	We report here the development of a novel class of N1-aryl-propane-1,3-diamine compounds using a structure-based approach that selectively inhibit the activity of the bromodomain of the human transcriptional co-activator PCAF, of which association with the HIV trans-activator Tat is essential for transcription and replication of the integrated HIV provirus.	n1-aryl-propane-1,3-diamine	51-78	lysine acetyltransferase 2B	Homo sapiens	221-225
15611041-5	2005	Purified recombinant Tat or Tat-derived synthetic peptides, spanning p300- and PCAF-binding sequences, inhibit histone H3/H4 acetylation in vitro.	Peptides	50-58	lysine acetyltransferase 2B	Homo sapiens	79-83
15578203-5	2005	Plasma epinephrine concentrations were significantly higher in CAF compared with PLA at pre-exercise [0.28 (0.05) nmol l(-1) versus 0.08 (0.03) nmol l(-1), P<0.01; mean (SE)] and immediately post-exercise [1.02 (0.16) nmol l(-1) versuss 0.60 (0.13) nmol l(-1), P<0.01].	Epinephrine	7-18	lysine acetyltransferase 2B	Homo sapiens	63-66
15496412-3	2004	Here we report that nerve growth factor receptor signaling induces nuclear translocation of PCAF and hGCN5 dependent upon the phosphorylation of Ser and Thr residues within their histone acetyltransferase domains, which requires activation of PI3K, Rsk2(pp90), and MSK-1.	Serine	145-148	lysine acetyltransferase 2B	Homo sapiens	92-96
15496412-3	2004	Here we report that nerve growth factor receptor signaling induces nuclear translocation of PCAF and hGCN5 dependent upon the phosphorylation of Ser and Thr residues within their histone acetyltransferase domains, which requires activation of PI3K, Rsk2(pp90), and MSK-1.	Threonine	153-156	lysine acetyltransferase 2B	Homo sapiens	92-96
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	2,2,4-trimethylpentane	256-265	lysine acetyltransferase 2B	Homo sapiens	51-54
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	Dioctyl Sulfosuccinic Acid	266-269	lysine acetyltransferase 2B	Homo sapiens	51-54
15549791-3	2004	The reduction of three aromatic ketones, acetophenone (AF), 4-methoxyacetophenone (MAF), and 3-chloroacetophenone (CAF), by NaBH(4) was followed by UV-vis spectroscopy in reverse micellar systems of water/AOT/isooctane at 25.0 degrees C (AOT is sodium 1,4-bis-2-ethylhexylsulfosuccinate).	omega-Chloroacetophenone	93-113	lysine acetyltransferase 2B	Homo sapiens	115-118
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	Water	217-222	lysine acetyltransferase 2B	Homo sapiens	51-54
15549791-3	2004	The reduction of three aromatic ketones, acetophenone (AF), 4-methoxyacetophenone (MAF), and 3-chloroacetophenone (CAF), by NaBH(4) was followed by UV-vis spectroscopy in reverse micellar systems of water/AOT/isooctane at 25.0 degrees C (AOT is sodium 1,4-bis-2-ethylhexylsulfosuccinate).	sodium borohydride	124-128	lysine acetyltransferase 2B	Homo sapiens	115-118
15549791-3	2004	The reduction of three aromatic ketones, acetophenone (AF), 4-methoxyacetophenone (MAF), and 3-chloroacetophenone (CAF), by NaBH(4) was followed by UV-vis spectroscopy in reverse micellar systems of water/AOT/isooctane at 25.0 degrees C (AOT is sodium 1,4-bis-2-ethylhexylsulfosuccinate).	Water	199-204	lysine acetyltransferase 2B	Homo sapiens	115-118
15155757-5	2004	Here we report that garcinol, a polyisoprenylated benzophenone derivative from Garcinia indica fruit rind, is a potent inhibitor of histone acetyltransferases p300 (IC50 approximately 7 microm) and PCAF (IC50 approximately 5 microm) both in vitro and in vivo.	garcinol	20-28	lysine acetyltransferase 2B	Homo sapiens	198-202
15549791-3	2004	The reduction of three aromatic ketones, acetophenone (AF), 4-methoxyacetophenone (MAF), and 3-chloroacetophenone (CAF), by NaBH(4) was followed by UV-vis spectroscopy in reverse micellar systems of water/AOT/isooctane at 25.0 degrees C (AOT is sodium 1,4-bis-2-ethylhexylsulfosuccinate).	Dioctyl Sulfosuccinic Acid	205-208	lysine acetyltransferase 2B	Homo sapiens	115-118
15549791-3	2004	The reduction of three aromatic ketones, acetophenone (AF), 4-methoxyacetophenone (MAF), and 3-chloroacetophenone (CAF), by NaBH(4) was followed by UV-vis spectroscopy in reverse micellar systems of water/AOT/isooctane at 25.0 degrees C (AOT is sodium 1,4-bis-2-ethylhexylsulfosuccinate).	2,2,4-trimethylpentane	209-218	lysine acetyltransferase 2B	Homo sapiens	115-118
15549791-3	2004	The reduction of three aromatic ketones, acetophenone (AF), 4-methoxyacetophenone (MAF), and 3-chloroacetophenone (CAF), by NaBH(4) was followed by UV-vis spectroscopy in reverse micellar systems of water/AOT/isooctane at 25.0 degrees C (AOT is sodium 1,4-bis-2-ethylhexylsulfosuccinate).	Dioctyl Sulfosuccinic Acid	238-241	lysine acetyltransferase 2B	Homo sapiens	115-118
15549791-3	2004	The reduction of three aromatic ketones, acetophenone (AF), 4-methoxyacetophenone (MAF), and 3-chloroacetophenone (CAF), by NaBH(4) was followed by UV-vis spectroscopy in reverse micellar systems of water/AOT/isooctane at 25.0 degrees C (AOT is sodium 1,4-bis-2-ethylhexylsulfosuccinate).	1,4-bis-2-ethylhexylsulfosuccinic acid	245-286	lysine acetyltransferase 2B	Homo sapiens	115-118
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	omega-Chloroacetophenone	29-49	lysine acetyltransferase 2B	Homo sapiens	51-54
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	sodium borohydride	61-79	lysine acetyltransferase 2B	Homo sapiens	51-54
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	sodium borohydride	81-85	lysine acetyltransferase 2B	Homo sapiens	51-54
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	Toluene	182-189	lysine acetyltransferase 2B	Homo sapiens	51-54
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	bhdc	190-194	lysine acetyltransferase 2B	Homo sapiens	51-54
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	Water	195-200	lysine acetyltransferase 2B	Homo sapiens	51-54
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	Toluene	205-212	lysine acetyltransferase 2B	Homo sapiens	51-54
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	Dioctyl Sulfosuccinic Acid	213-216	lysine acetyltransferase 2B	Homo sapiens	51-54
15549792-3	2004	Kinetics of the reduction of 3-chloroacetophenone (CAF) with sodium borohydride (NaBH(4)) were followed by UV-vis spectroscopy at 27.0 degrees C in different reverse micellar media, toluene/BHDC/water and toluene/AOT/water, and compared with results in an isooctane/AOT/water reverse micellar system.	Water	217-222	lysine acetyltransferase 2B	Homo sapiens	51-54
15382140-5	2004	For example, bromodomains of Gcn5, PCAF, TAF1 and CBP are able to recognize acetyllysine residues in histones, HIV Tat, p53, c-Myb or MyoD.	N-epsilon-Acetyl-L-lysine	76-88	lysine acetyltransferase 2B	Homo sapiens	35-39
15352032-7	2004	The mean number of colonies in soft agar was 120.5 for CAF vs. 18.2 for NHPF (p < 0.05).	Agar	36-40	lysine acetyltransferase 2B	Homo sapiens	55-58
15283601-10	2004	The Alexa Fluor 350 tag yielded a significantly higher signal relative to that for the CAF tag, likely due to the increased hydrophobicity of the coumarin structure.	coumarin	146-154	lysine acetyltransferase 2B	Homo sapiens	87-90
15153330-7	2004	PCAF induction by p53 activity was further demonstrated in wild-type p53 MCF10A cells when PCAF expression was induced following activation of endogenous wild-type p53 with doxorubicin in a dose- and time-dependent manner.	Doxorubicin	173-184	lysine acetyltransferase 2B	Homo sapiens	91-95
15025563-15	2004	RA and calcium signalling induced exchange of CBP and P/CAF occupancy at the AP-1 sites of the involucrin promoter.	Calcium	7-14	lysine acetyltransferase 2B	Homo sapiens	54-59
15123636-6	2004	Finally, we report that the formation of E2F1-p300/CREB-binding protein-associated factor (P/CAF) complexes is preferentially induced in doxorubicin-treated cells, and that P/CAF acetyltransferase (HAT), but not p300 HAT activity, is required for a significant E2F1 stabilization and accumulation.	Doxorubicin	137-148	lysine acetyltransferase 2B	Homo sapiens	91-96
15123636-6	2004	Finally, we report that the formation of E2F1-p300/CREB-binding protein-associated factor (P/CAF) complexes is preferentially induced in doxorubicin-treated cells, and that P/CAF acetyltransferase (HAT), but not p300 HAT activity, is required for a significant E2F1 stabilization and accumulation.	Doxorubicin	137-148	lysine acetyltransferase 2B	Homo sapiens	173-178
15025563-5	2004	Recently, a dominant-negative construct of the transcriptional co-activator P/CAF [p300/CBP-associated factor, where CBP stands for CREB (cAMP-response-element-binding protein)-binding protein] was shown to inhibit involucrin expression in immortalized keratinocytes [Kawabata, Kawahara, Kanekura, Araya, Daitoku, Hata, Miura, Fukamizu, Kanzaki, Maruyama and Nakajima (2002) J. Biol.	Cyclic AMP	138-142	lysine acetyltransferase 2B	Homo sapiens	76-81
15025563-5	2004	Recently, a dominant-negative construct of the transcriptional co-activator P/CAF [p300/CBP-associated factor, where CBP stands for CREB (cAMP-response-element-binding protein)-binding protein] was shown to inhibit involucrin expression in immortalized keratinocytes [Kawabata, Kawahara, Kanekura, Araya, Daitoku, Hata, Miura, Fukamizu, Kanzaki, Maruyama and Nakajima (2002) J. Biol.	Cyclic AMP	138-142	lysine acetyltransferase 2B	Homo sapiens	83-109
15153330-7	2004	PCAF induction by p53 activity was further demonstrated in wild-type p53 MCF10A cells when PCAF expression was induced following activation of endogenous wild-type p53 with doxorubicin in a dose- and time-dependent manner.	Doxorubicin	173-184	lysine acetyltransferase 2B	Homo sapiens	0-4
15153330-8	2004	Furthermore, the doxorubicin-induced increase in PCAF expression was blocked by pretreatment of the MCF10A cells with siRNA (small interfering RNA) targeted against p53 mRNA.	Doxorubicin	17-28	lysine acetyltransferase 2B	Homo sapiens	49-53
14661947-6	2003	In contrast, while the histone H3 complex shows extensive interactions with tGcn5 and peptide residues N-terminal to the target lysine, the corresponding residues in histone H4 and p53 are disordered, suggesting that the N-terminal substrate region plays an important role in the enhanced affinity of the Gcn5/PCAF HAT proteins for histone H3.	Lysine	128-134	lysine acetyltransferase 2B	Homo sapiens	310-314
14661947-0	2003	Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates.	nonhistone	84-94	lysine acetyltransferase 2B	Homo sapiens	25-29
15023334-6	2004	We show that CBP and PCAF efficiently acetylate K542 in vitro and associate with Ku70 in vivo.	methylprednisolone aceponate	48-52	lysine acetyltransferase 2B	Homo sapiens	21-25
12726776-1	2003	Coactivators such as cyclic AMP-response-element binding protein (CREB)-binding protein (CBP) and p300/CBP associated factor (P/CAF) play a crucial role in coordinating and cointegrating eukaryotic transcription.	Cyclic AMP	21-31	lysine acetyltransferase 2B	Homo sapiens	126-131
12917345-3	2003	Whereas p300 acetylates two lysine residues (K33 and K116) within the ER81 N-terminal transactivation domain, P/CAF targets only K116.	cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate	129-133	lysine acetyltransferase 2B	Homo sapiens	110-115
14661947-3	2003	Interestingly, the Gcn5/PCAF HAT family has a remarkable ability to acetylate lysine residues within diverse cognate sites such as those found around lysines 14, 8, and 320 of histones H3, H4, and p53, respectively.	Lysine	78-84	lysine acetyltransferase 2B	Homo sapiens	24-28
14661947-3	2003	Interestingly, the Gcn5/PCAF HAT family has a remarkable ability to acetylate lysine residues within diverse cognate sites such as those found around lysines 14, 8, and 320 of histones H3, H4, and p53, respectively.	Lysine	150-157	lysine acetyltransferase 2B	Homo sapiens	24-28
14661947-5	2003	A comparison of these structures with tGcn5 bound to histone H3 reveals that the Gcn5/PCAF HATs can accommodate divergent substrates by utilizing analogous interactions with the lysine target and two C-terminal residues with a related chemical nature, suggesting that these interactions play a general role in Gcn5/PCAF substrate binding selectivity.	Lysine	178-184	lysine acetyltransferase 2B	Homo sapiens	86-90
14622953-7	2003	p300 and its associated factor PCAF levels but not Srb7, Med7, or TFII(B) were increased by phorbol ester or tumor necrosis factor alpha stimulation.	Phorbol Esters	92-105	lysine acetyltransferase 2B	Homo sapiens	31-35
12878208-7	2003	Both P/CAF and GCN5 efficiently acetylate AME in vivo in the central region.	acetylate	32-41	lysine acetyltransferase 2B	Homo sapiens	5-10
12878208-7	2003	Both P/CAF and GCN5 efficiently acetylate AME in vivo in the central region.	ame	42-45	lysine acetyltransferase 2B	Homo sapiens	5-10
12720548-0	2003	p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene.	Uridine Diphosphate N-Acetylgalactosamine	95-129	lysine acetyltransferase 2B	Homo sapiens	0-26
12720548-0	2003	p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene.	Uridine Diphosphate N-Acetylgalactosamine	95-129	lysine acetyltransferase 2B	Homo sapiens	28-33
12720548-11	2003	These results indicate a correlation between acetylation of NRF-1 by P/CAF and the butyrate-induced expression of the GalNAc-T3 gene.	Butyrates	83-91	lysine acetyltransferase 2B	Homo sapiens	69-74
12888487-6	2003	The intramolecular acetylation targets five lysines (416-442) at the P/CAF C-terminus, which are in the nuclear localisation signal (NLS).	Lysine	44-51	lysine acetyltransferase 2B	Homo sapiens	69-74
12726776-1	2003	Coactivators such as cyclic AMP-response-element binding protein (CREB)-binding protein (CBP) and p300/CBP associated factor (P/CAF) play a crucial role in coordinating and cointegrating eukaryotic transcription.	Cyclic AMP	21-31	lysine acetyltransferase 2B	Homo sapiens	98-124
12758070-4	2003	We found that CBP and PCAF acetylated KLF13 at specific lysine residues in the zinc finger domain of KLF13.	Lysine	56-62	lysine acetyltransferase 2B	Homo sapiens	22-26
12374802-7	2002	However, a mutant that cannot be acetylated by PCAF due to a change in the surrounding amino acid context of lysine 92 showed increased DNA binding and activity compared with wild type IRF7.	Lysine	109-115	lysine acetyltransferase 2B	Homo sapiens	47-51
12649201-6	2003	Finally, these triterpenoids induce expression of the transcriptional coactivator p300-CBP-associated factor and synergize with TGF-beta in this regard.	triterpenoids	15-28	lysine acetyltransferase 2B	Homo sapiens	82-108
12419806-3	2003	Here, we show that the p65 subunit of NF-kappaB is acetylated by both p300 and PCAF on lysines 122 and 123.	Lysine	87-94	lysine acetyltransferase 2B	Homo sapiens	79-83
12624186-3	2003	In attempts to identify CAF, we discovered that certain protease inhibitors, particularly leupeptin, can block, by up to 95%, the anti-HIV activity in CD8+ cell culture fluids as well as inhibit CNAR.	leupeptin	90-99	lysine acetyltransferase 2B	Homo sapiens	24-27
11741939-6	2002	Although the up-regulation of ap70 and ap78 was not influenced by GF109203X, a specific inhibitor of protein kinase C (PKC), the calcium-induced accumulation of ap97 and the induction of P/CAF HAT activity were similarly attenuated by GF109203X.	Calcium	129-136	lysine acetyltransferase 2B	Homo sapiens	187-192
12500987-6	2002	Plasma (caffeine) was significantly higher during Caf (0.43 +/- 0.56 and 1.11 +/- 1.78 mM pre vs. post Pl; and 47.32 +/- 12.01 and 72.43 +/- 29.08 mM pre vs. post Caf).	Caffeine	8-16	lysine acetyltransferase 2B	Homo sapiens	50-53
12500987-6	2002	Plasma (caffeine) was significantly higher during Caf (0.43 +/- 0.56 and 1.11 +/- 1.78 mM pre vs. post Pl; and 47.32 +/- 12.01 and 72.43 +/- 29.08 mM pre vs. post Caf).	Caffeine	8-16	lysine acetyltransferase 2B	Homo sapiens	163-166
12486002-4	2002	It has recently been shown that acetylation at a single lysine, residue 50, regulated the association of Tat with PCAF.	Lysine	56-62	lysine acetyltransferase 2B	Homo sapiens	114-118
12486002-8	2002	Thus, differential lysine acetylation of Tat coordinates the interactions with its co-activators, cyclin T1 and PCAF.	Lysine	19-25	lysine acetyltransferase 2B	Homo sapiens	112-116
12465396-3	2002	The metastases partially responded to 10 cycles of CAF (cyclophosphamide, adriamycin, 5-fluorouracil).	Cyclophosphamide	56-72	lysine acetyltransferase 2B	Homo sapiens	51-54
12465396-3	2002	The metastases partially responded to 10 cycles of CAF (cyclophosphamide, adriamycin, 5-fluorouracil).	Doxorubicin	74-84	lysine acetyltransferase 2B	Homo sapiens	51-54
12465396-3	2002	The metastases partially responded to 10 cycles of CAF (cyclophosphamide, adriamycin, 5-fluorouracil).	Fluorouracil	86-100	lysine acetyltransferase 2B	Homo sapiens	51-54
11741939-8	2002	Our results suggest that P/CAF HAT activity and induction of ap97 are involved in calcium-dependent keratinocyte differentiation.	Calcium	82-89	lysine acetyltransferase 2B	Homo sapiens	25-30
11812172-10	2002	CAF chemotherapy (cyclophosphamide, adriamycin, and 5-fluorouracil) is predicted to be more effective than CMF (cyclophosphamide, methotrexate, and 5-fluorouracil).	Cyclophosphamide	18-34	lysine acetyltransferase 2B	Homo sapiens	0-3
11931765-0	2002	Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.	Lysine	20-26	lysine acetyltransferase 2B	Homo sapiens	63-67
11931765-2	2002	Tat transactivation activity is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF).	Lysine	45-51	lysine acetyltransferase 2B	Homo sapiens	160-186
11931765-2	2002	Tat transactivation activity is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF).	Lysine	45-51	lysine acetyltransferase 2B	Homo sapiens	188-192
11931765-3	2002	Here, we show that the bromodomain of PCAF binds specifically to HIV-1 Tat acetylated at lysine 50 and that this interaction competes effectively against HIV-1 TAR RNA binding to the lysine-acetylated Tat.	Lysine	89-95	lysine acetyltransferase 2B	Homo sapiens	38-42
11931765-3	2002	Here, we show that the bromodomain of PCAF binds specifically to HIV-1 Tat acetylated at lysine 50 and that this interaction competes effectively against HIV-1 TAR RNA binding to the lysine-acetylated Tat.	Lysine	183-189	lysine acetyltransferase 2B	Homo sapiens	38-42
11931765-4	2002	The three-dimensional solution structure of the PCAF bromodomain in complex with a lysine 50-acetylated Tat peptide together with biochemical analyses provides the structural basis for the specificity of this molecular recognition and reveals insights into the differences in ligand selectivity of bromodomains.	Lysine	83-89	lysine acetyltransferase 2B	Homo sapiens	48-52
11812172-10	2002	CAF chemotherapy (cyclophosphamide, adriamycin, and 5-fluorouracil) is predicted to be more effective than CMF (cyclophosphamide, methotrexate, and 5-fluorouracil).	Doxorubicin	36-46	lysine acetyltransferase 2B	Homo sapiens	0-3
11812172-10	2002	CAF chemotherapy (cyclophosphamide, adriamycin, and 5-fluorouracil) is predicted to be more effective than CMF (cyclophosphamide, methotrexate, and 5-fluorouracil).	Fluorouracil	52-66	lysine acetyltransferase 2B	Homo sapiens	0-3
11812172-10	2002	CAF chemotherapy (cyclophosphamide, adriamycin, and 5-fluorouracil) is predicted to be more effective than CMF (cyclophosphamide, methotrexate, and 5-fluorouracil).	Cyclophosphamide	112-128	lysine acetyltransferase 2B	Homo sapiens	0-3
11812172-10	2002	CAF chemotherapy (cyclophosphamide, adriamycin, and 5-fluorouracil) is predicted to be more effective than CMF (cyclophosphamide, methotrexate, and 5-fluorouracil).	Methotrexate	130-142	lysine acetyltransferase 2B	Homo sapiens	0-3
11812172-10	2002	CAF chemotherapy (cyclophosphamide, adriamycin, and 5-fluorouracil) is predicted to be more effective than CMF (cyclophosphamide, methotrexate, and 5-fluorouracil).	Fluorouracil	148-162	lysine acetyltransferase 2B	Homo sapiens	0-3
11791385-3	2001	Because CAF therapy was not effective, we tried to treat the patient with systemic and intra-arterial chemotherapy using paclitaxel.	Paclitaxel	121-131	lysine acetyltransferase 2B	Homo sapiens	8-11
11741482-1	2001	Caffeine (CAF), a methyl-substituted xanthine, interacts with polyaromatic DNA intercalators and has been hypothesized to interfere with their intercalation into DNA.	Caffeine	0-8	lysine acetyltransferase 2B	Homo sapiens	10-13
11741482-1	2001	Caffeine (CAF), a methyl-substituted xanthine, interacts with polyaromatic DNA intercalators and has been hypothesized to interfere with their intercalation into DNA.	methyl-substituted xanthine	18-45	lysine acetyltransferase 2B	Homo sapiens	10-13
11514574-9	2001	Consistent with a recent report, we show that nuclear localization of CIITA is enhanced by lysine 144, an in vitro target of pCAF-mediated HAT.	Lysine	91-97	lysine acetyltransferase 2B	Homo sapiens	125-129
11911296-10	2001	In the CAF and CEF group, the HDRA sensitivity to CDDP was significantly lower in recurrent disease (p<0.005) than that of primary breast cancer suggesting that one agent can induce resistance to another.	Cisplatin	50-54	lysine acetyltransferase 2B	Homo sapiens	7-10
11736870-5	2001	CONCLUSIONS: The variability over time of the PAX/CAF ratio is not influenced by age.	pax	46-49	lysine acetyltransferase 2B	Homo sapiens	50-53
11509661-3	2001	We previously showed that the CtBP-binding motif in E1A is flanked by a Lys residue and suggested that acetylation of this residue by the p300/CBP-associated factor P/CAF disrupts the CtBP interaction.	ctbp	30-34	lysine acetyltransferase 2B	Homo sapiens	138-170
11602348-9	2001	Moreover, PCAF and the Brahma/SWI2-related protein BRG-1, which is a key factor of the human ATP-dependent chromatin remodelling complex SWI/SNF, synergistically up-regulate the enhancer A. Synergistic activation requires the HAT domain of PCAF.	Adenosine Triphosphate	93-96	lysine acetyltransferase 2B	Homo sapiens	10-14
11602348-9	2001	Moreover, PCAF and the Brahma/SWI2-related protein BRG-1, which is a key factor of the human ATP-dependent chromatin remodelling complex SWI/SNF, synergistically up-regulate the enhancer A. Synergistic activation requires the HAT domain of PCAF.	Adenosine Triphosphate	93-96	lysine acetyltransferase 2B	Homo sapiens	240-244
11486036-5	2001	YY1 was acetylated in two regions: both p300 and PCAF acetylated the central glycine-lysine-rich domain of residues 170 to 200, and PCAF also acetylated YY1 at the C-terminal DNA-binding zinc finger domain.	Glycine	77-84	lysine acetyltransferase 2B	Homo sapiens	49-53
11486036-5	2001	YY1 was acetylated in two regions: both p300 and PCAF acetylated the central glycine-lysine-rich domain of residues 170 to 200, and PCAF also acetylated YY1 at the C-terminal DNA-binding zinc finger domain.	Glycine	77-84	lysine acetyltransferase 2B	Homo sapiens	132-136
11486036-5	2001	YY1 was acetylated in two regions: both p300 and PCAF acetylated the central glycine-lysine-rich domain of residues 170 to 200, and PCAF also acetylated YY1 at the C-terminal DNA-binding zinc finger domain.	Lysine	85-91	lysine acetyltransferase 2B	Homo sapiens	49-53
11486036-5	2001	YY1 was acetylated in two regions: both p300 and PCAF acetylated the central glycine-lysine-rich domain of residues 170 to 200, and PCAF also acetylated YY1 at the C-terminal DNA-binding zinc finger domain.	Lysine	85-91	lysine acetyltransferase 2B	Homo sapiens	132-136
11509661-3	2001	We previously showed that the CtBP-binding motif in E1A is flanked by a Lys residue and suggested that acetylation of this residue by the p300/CBP-associated factor P/CAF disrupts the CtBP interaction.	Lysine	72-75	lysine acetyltransferase 2B	Homo sapiens	138-170
11509661-3	2001	We previously showed that the CtBP-binding motif in E1A is flanked by a Lys residue and suggested that acetylation of this residue by the p300/CBP-associated factor P/CAF disrupts the CtBP interaction.	ctbp	184-188	lysine acetyltransferase 2B	Homo sapiens	138-170
11304541-3	2001	U937 cells are shown to respond to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce expression of histone acetylases p300 and p300/CBP-associated factor (PCAF).	Phorbol Esters	35-48	lysine acetyltransferase 2B	Homo sapiens	144-170
11487463-2	2001	The bromodomain of p/CAF, the only solution structure of a bromodomain that has been solved to date, reveals that the motif binds N-acetyl-lysine groups, presumably to anchor enzymatic functions to histones and by extension to chromatin.	N(alpha)-acetyllysine	130-145	lysine acetyltransferase 2B	Homo sapiens	19-24
21047472-1	2001	BACKGROUND: To investigate the enhancing effect of caffeine(CAF) on the anticancer activity of cisplatin on human lung cancer SPC-A-1 cells in vitro and study whether this enhancing effect of caffeine could be inhibited by phenobarbital(PBT).	Caffeine	51-59	lysine acetyltransferase 2B	Homo sapiens	60-63
21047472-1	2001	BACKGROUND: To investigate the enhancing effect of caffeine(CAF) on the anticancer activity of cisplatin on human lung cancer SPC-A-1 cells in vitro and study whether this enhancing effect of caffeine could be inhibited by phenobarbital(PBT).	Cisplatin	95-104	lysine acetyltransferase 2B	Homo sapiens	60-63
11560082-9	2001	CAF did lead to a higher plasma lactate concentration during exercise (P < 0.05).	Lactic Acid	32-39	lysine acetyltransferase 2B	Homo sapiens	0-3
11560082-11	2001	However, CAF did lead to elevated plasma lactate concentrations.	Lactic Acid	41-48	lysine acetyltransferase 2B	Homo sapiens	9-12
11304541-3	2001	U937 cells are shown to respond to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce expression of histone acetylases p300 and p300/CBP-associated factor (PCAF).	Phorbol Esters	35-48	lysine acetyltransferase 2B	Homo sapiens	172-176
11304541-3	2001	U937 cells are shown to respond to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce expression of histone acetylases p300 and p300/CBP-associated factor (PCAF).	Tetradecanoylphorbol Acetate	49-85	lysine acetyltransferase 2B	Homo sapiens	144-170
11304541-3	2001	U937 cells are shown to respond to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce expression of histone acetylases p300 and p300/CBP-associated factor (PCAF).	Tetradecanoylphorbol Acetate	49-85	lysine acetyltransferase 2B	Homo sapiens	172-176
11304541-3	2001	U937 cells are shown to respond to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce expression of histone acetylases p300 and p300/CBP-associated factor (PCAF).	Tetradecanoylphorbol Acetate	87-90	lysine acetyltransferase 2B	Homo sapiens	144-170
11304541-3	2001	U937 cells are shown to respond to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce expression of histone acetylases p300 and p300/CBP-associated factor (PCAF).	Tetradecanoylphorbol Acetate	87-90	lysine acetyltransferase 2B	Homo sapiens	172-176
11304541-5	2001	Interestingly, full-length IRF-2 in TPA-treated U937 cells occurred as a complex with p300 as well as PCAF and was itself acetylated.	Tetradecanoylphorbol Acetate	36-39	lysine acetyltransferase 2B	Homo sapiens	102-106
11329786-1	2001	A 73-year-old woman underwent docetaxel therapy for lung metastasis from breast cancer after having received CAF therapy.	Docetaxel	30-39	lysine acetyltransferase 2B	Homo sapiens	109-112
11429627-5	2001	The rate of carbohydrate oxidation was higher (micromol kg-1 min-1: CHO, 243 +/- 39 and CHO + CAF, 239 +/- 30 vs.	Carbohydrates	12-24	lysine acetyltransferase 2B	Homo sapiens	94-97
11429627-8	2001	FAT, 35 +/- 19 and FAT + CAF, 37 +/- 17; P < 0.05) with carbohydrate than fat ingestion.	Carbohydrates	59-71	lysine acetyltransferase 2B	Homo sapiens	25-28
11046145-4	2000	Interestingly, CBP and PCAF acetylate CIITA at lysine residues within a nuclear localization signal.	Lysine	47-53	lysine acetyltransferase 2B	Homo sapiens	23-27
11118214-4	2000	P/CAF-mediated acetylation, which mapped to a lysine-rich motif in the loop region, increased TAL1 binding to DNA while selectively inhibiting its interaction with the transcriptional co-repressor mSin3A.	Lysine	46-52	lysine acetyltransferase 2B	Homo sapiens	0-5
11142168-0	2000	[A case of breast cancer with multiple organ metastases responding remarkably to combination therapy of CAF (cyclophosphamide, adriamycin and 5-FU), 5"-DFUR and MPA (medroxyprogesterone acetate)].	Cyclophosphamide	109-125	lysine acetyltransferase 2B	Homo sapiens	104-107
11142168-0	2000	[A case of breast cancer with multiple organ metastases responding remarkably to combination therapy of CAF (cyclophosphamide, adriamycin and 5-FU), 5"-DFUR and MPA (medroxyprogesterone acetate)].	Doxorubicin	127-137	lysine acetyltransferase 2B	Homo sapiens	104-107
11142168-0	2000	[A case of breast cancer with multiple organ metastases responding remarkably to combination therapy of CAF (cyclophosphamide, adriamycin and 5-FU), 5"-DFUR and MPA (medroxyprogesterone acetate)].	Fluorouracil	142-146	lysine acetyltransferase 2B	Homo sapiens	104-107
10944526-4	2000	In vitro, MyoD is acetylated both by CBP/p300 and by PCAF on two lysines located at the boundary of the DNA binding domain.	Lysine	65-72	lysine acetyltransferase 2B	Homo sapiens	53-57
11046145-6	2000	The shuttling behavior and activity of the protein are regulated by acetylation: overexpression of PCAF or inhibition of cellular deacetylases by trichostatin A increases the nuclear accumulation of CIITA in a manner determined by the presence of the acetylation target lysines.	Lysine	270-277	lysine acetyltransferase 2B	Homo sapiens	99-103
11016005-3	2000	After three courses of CAF therapy (cyclophosphamide, doxorubicin (DXR), 5-FU), the primary tumor was decreased by 56% and the liver metastases had disappeared.	Cyclophosphamide	36-52	lysine acetyltransferase 2B	Homo sapiens	23-26
11016005-3	2000	After three courses of CAF therapy (cyclophosphamide, doxorubicin (DXR), 5-FU), the primary tumor was decreased by 56% and the liver metastases had disappeared.	Doxorubicin	54-65	lysine acetyltransferase 2B	Homo sapiens	23-26
11016005-3	2000	After three courses of CAF therapy (cyclophosphamide, doxorubicin (DXR), 5-FU), the primary tumor was decreased by 56% and the liver metastases had disappeared.	Doxorubicin	67-70	lysine acetyltransferase 2B	Homo sapiens	23-26
11016005-3	2000	After three courses of CAF therapy (cyclophosphamide, doxorubicin (DXR), 5-FU), the primary tumor was decreased by 56% and the liver metastases had disappeared.	Fluorouracil	73-77	lysine acetyltransferase 2B	Homo sapiens	23-26
10777508-6	2000	PCAF-catalyzed acetylation of the substrate H3-20 was shown to be specific for Lys-14, analogous to its behavior with the full-length histone H3 protein.	Lysine	79-82	lysine acetyltransferase 2B	Homo sapiens	0-4
10891493-6	2000	PCAF binds to the E1B 55-kDa protein and to a region near the C terminus of p53 encompassing Lys-320, the specific PCAF acetylation site.	Lysine	93-96	lysine acetyltransferase 2B	Homo sapiens	0-4
10891493-6	2000	PCAF binds to the E1B 55-kDa protein and to a region near the C terminus of p53 encompassing Lys-320, the specific PCAF acetylation site.	Lysine	93-96	lysine acetyltransferase 2B	Homo sapiens	115-119
10777508-11	2000	Taken together, these inhibition patterns support an ordered BiBi kinetic mechanism for PCAF in which acetyl-CoA binding precedes H3-20 binding.	Acetyl Coenzyme A	102-112	lysine acetyltransferase 2B	Homo sapiens	88-92
10852958-7	2000	Acetylation of CDP/cut by PCAF is directed at conserved lysine residues near the homeodomain region and regulates CDP/cut function.	Lysine	56-62	lysine acetyltransferase 2B	Homo sapiens	26-30
10841572-3	2000	In the present study, we tested whether ET-743 could block activation of the MDR1 promoter by agents that mediate their effect through the NF-Y/PCAF complex.	Trabectedin	40-46	lysine acetyltransferase 2B	Homo sapiens	144-148
10619020-4	1999	Here, we provide a molecular explanation of this phenomenon and report that MyoD is directly acetylated by PCAF at evolutionarily conserved lysines.	Lysine	140-147	lysine acetyltransferase 2B	Homo sapiens	107-111
10567539-6	1999	Point mutations at Tax amino acid 318 (TaxS318A) or 319 to 320 (Tax M47), which have decreased or no activity on the HTLV-1 promoter, are defective for PCAF binding.	taxs318a	39-47	lysine acetyltransferase 2B	Homo sapiens	152-156
10723546-8	2000	The data indicate that CAF forms stacking complexes with DAPI and EB, thus effectively lowering the concentration of the free ligands in the solution, and therefore, CAF can be used to modulate aromatic compound activity.	DAPI	57-61	lysine acetyltransferase 2B	Homo sapiens	23-26
10723546-8	2000	The data indicate that CAF forms stacking complexes with DAPI and EB, thus effectively lowering the concentration of the free ligands in the solution, and therefore, CAF can be used to modulate aromatic compound activity.	DAPI	57-61	lysine acetyltransferase 2B	Homo sapiens	166-169
10723546-8	2000	The data indicate that CAF forms stacking complexes with DAPI and EB, thus effectively lowering the concentration of the free ligands in the solution, and therefore, CAF can be used to modulate aromatic compound activity.	Ethidium	66-68	lysine acetyltransferase 2B	Homo sapiens	23-26
10723546-8	2000	The data indicate that CAF forms stacking complexes with DAPI and EB, thus effectively lowering the concentration of the free ligands in the solution, and therefore, CAF can be used to modulate aromatic compound activity.	Ethidium	66-68	lysine acetyltransferase 2B	Homo sapiens	166-169
10644769-3	2000	We have previously shown that the CCAAT box-binding protein, NF-Y, mediates MDR1 activation by the histone deacetylase inhibitors, trichostatin A and sodium butyrate, through the recruitment of the co-activator, P/CAF.	trichostatin A	131-145	lysine acetyltransferase 2B	Homo sapiens	212-217
10644769-3	2000	We have previously shown that the CCAAT box-binding protein, NF-Y, mediates MDR1 activation by the histone deacetylase inhibitors, trichostatin A and sodium butyrate, through the recruitment of the co-activator, P/CAF.	Butyric Acid	150-165	lysine acetyltransferase 2B	Homo sapiens	212-217
10393169-4	1999	A correlation of the structure with the extensive mutagenesis data for PCAF and the homologous yeast GCN5 protein implicates the cleft and the N- and C-terminal protein segments as playing an important role in histone substrate binding, and a glutamate residue in the protein core as playing an essential catalytic role.	Glutamic Acid	243-252	lysine acetyltransferase 2B	Homo sapiens	71-75
10365964-7	1999	The nature of the recognition of acetyl-lysine by the P/CAF bromodomain is similar to that of acetyl-CoA by histone acetyltransferase.	N(alpha)-acetyllysine	33-46	lysine acetyltransferase 2B	Homo sapiens	54-59
10481282-0	1999	1H, 15N and 13C resonance assignments for the bromodomain of the histone acetyltransferase P/CAF.	Hydrogen	0-2	lysine acetyltransferase 2B	Homo sapiens	65-96
10481282-0	1999	1H, 15N and 13C resonance assignments for the bromodomain of the histone acetyltransferase P/CAF.	15n	4-7	lysine acetyltransferase 2B	Homo sapiens	65-96
10481282-0	1999	1H, 15N and 13C resonance assignments for the bromodomain of the histone acetyltransferase P/CAF.	13c	12-15	lysine acetyltransferase 2B	Homo sapiens	65-96
10373431-2	1999	Here we demonstrate that TFTC, similar to other TBP-free TAFII complexes (yeast SAGA, hSTAGA, and hPCAF) contains the acetyltransferase hGCN5 and is able to acetylate histones in both a free and a nucleosomal context.	tftc	25-29	lysine acetyltransferase 2B	Homo sapiens	98-103
10365964-7	1999	The nature of the recognition of acetyl-lysine by the P/CAF bromodomain is similar to that of acetyl-CoA by histone acetyltransferase.	Acetyl Coenzyme A	94-104	lysine acetyltransferase 2B	Homo sapiens	54-59
9891054-5	1999	In this study, we demonstrate that PCAF also acetylates p53 in vitro at a lysine residue distinct from that acetylated by p300 and thereby increases p53"s ability to bind to its cognate DNA site.	Lysine	74-80	lysine acetyltransferase 2B	Homo sapiens	35-39
10022868-9	1999	These results demonstrate that PCAF is a phorbol ester-inducible coactivator of the IRF proteins which contributes to the establishment of type I IFN responsiveness.	Phorbol Esters	41-54	lysine acetyltransferase 2B	Homo sapiens	31-35
10207070-3	1999	Using mass spectrum sequence analysis, we identified the lysine at position 2 as the predominant site acetylated by PCAF.	Lysine	57-63	lysine acetyltransferase 2B	Homo sapiens	116-120
10207070-4	1999	Lysine 2 is a prominent acetylation site in vivo, suggesting that this PCAF-mediated acetylation is physiologically relevant.	Lysine	0-6	lysine acetyltransferase 2B	Homo sapiens	71-75
10022868-0	1999	The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness.	Phorbol Esters	32-45	lysine acetyltransferase 2B	Homo sapiens	22-26
10022868-6	1999	Further studies showed that expression of PCAF and other histone acetylases was markedly induced in U937 cells upon phorbol ester treatment, which led to increased recruitment of PCAF to the IRF-ISRE complexes.	Phorbol Esters	116-129	lysine acetyltransferase 2B	Homo sapiens	42-46
10022868-6	1999	Further studies showed that expression of PCAF and other histone acetylases was markedly induced in U937 cells upon phorbol ester treatment, which led to increased recruitment of PCAF to the IRF-ISRE complexes.	Phorbol Esters	116-129	lysine acetyltransferase 2B	Homo sapiens	179-183
9891054-6	1999	We have generated antibodies to acetylated p53 peptides at either of the two lysine residues that are targeted by PCAF or p300 and have demonstrated that these antibodies are highly specific for both acetylation and the particular site.	Lysine	77-83	lysine acetyltransferase 2B	Homo sapiens	114-118
9880483-4	1999	PCAF primarily acetylates lysine 14 of H3 but also less efficiently acetylates lysine 8 of H4.	Lysine	26-32	lysine acetyltransferase 2B	Homo sapiens	0-4
9880483-4	1999	PCAF primarily acetylates lysine 14 of H3 but also less efficiently acetylates lysine 8 of H4.	Lysine	79-85	lysine acetyltransferase 2B	Homo sapiens	0-4
9809067-2	1998	We show that CBP and P/CAF acetylate HMG I(Y), the essential architectural component required for enhanceosome assembly, at distinct lysine residues, causing distinct effects on transcription.	Lysine	133-139	lysine acetyltransferase 2B	Homo sapiens	21-26
10211086-3	1999	They received tamoxifen 30 mg daily orally and by randomisation either 400 mg/m2, cyclophosphamide, 25 mg/m2 doxorubicin and 500 mg/m2 5-fluorouracil (CAF) or 40 mg/m2 methotrexate instead of Dox (CMF) intravenously (i.v.)	Fluorouracil	135-149	lysine acetyltransferase 2B	Homo sapiens	151-154
10211086-6	1999	Among 341 eligible patients the response rate and median time to progression was significantly in favour of CAF: 53% CAF versus 36% CMF (P = 0.002) and 11.8 months CAF versus 6.5 months CMF (P = 0.001).	CMF regimen	132-135	lysine acetyltransferase 2B	Homo sapiens	108-111
9751061-4	1998	Furthermore, the histone acetyltransferase functions of CBP or p/CAF are required for Pit-1 function that is stimulated by cyclic AMP or growth factors, respectively.	Cyclic AMP	123-133	lysine acetyltransferase 2B	Homo sapiens	63-68
9725052-0	1998	[The in vitro combination-effect of toremifene with CAF (cyclophosphamide, adriamycin, 5-fluorouracil) on growth of various human mammary carcinomas].	Cyclophosphamide	57-73	lysine acetyltransferase 2B	Homo sapiens	52-55
9744860-4	1998	p300 acetylates Lys-382 in the carboxy-terminal region of p53, whereas PCAF acetylates Lys-320 in the nuclear localization signal.	Lysine	87-90	lysine acetyltransferase 2B	Homo sapiens	71-75
9687513-6	1998	Binding of E1A to P/CAF is direct, independent of CBP and requires residues within E1A conserved region 1.	Phosphorus	18-19	lysine acetyltransferase 2B	Homo sapiens	20-23
9725052-0	1998	[The in vitro combination-effect of toremifene with CAF (cyclophosphamide, adriamycin, 5-fluorouracil) on growth of various human mammary carcinomas].	Doxorubicin	75-85	lysine acetyltransferase 2B	Homo sapiens	52-55
9725052-0	1998	[The in vitro combination-effect of toremifene with CAF (cyclophosphamide, adriamycin, 5-fluorouracil) on growth of various human mammary carcinomas].	Fluorouracil	87-101	lysine acetyltransferase 2B	Homo sapiens	52-55
9725052-9	1998	In conclusion, the addition of high-dose TOR to CAF therapy might be useful for advanced/recurrent breast cancer.	Toremifene	41-44	lysine acetyltransferase 2B	Homo sapiens	48-51
9620851-3	1998	First, we demonstrate that the RXR/RAR heterodimer directly recruits PCAF from mammalian cell extracts in a ligand-dependent manner and that increased expression of PCAF leads to enhanced retinoid-responsive transcription.	Retinoids	188-196	lysine acetyltransferase 2B	Homo sapiens	165-169
9492821-7	1998	Patients with rapidly progressing and/or endocrine-resistant tumor should be treated with anthracycline containing regimen such as CAF (cyclophosphamide, adriamycin, 5-fluorouracil).	Anthracyclines	90-103	lysine acetyltransferase 2B	Homo sapiens	131-134
9586579-3	1998	The active fraction containing CAF partially purified with PEG and ammonium sulfate results in marked activation of the complement system via the alternative pathway when interacted with CAF-depleted serum, whereas the active fraction or CAF-depleted serum alone does not activate the complement.	Polyethylene Glycols	59-62	lysine acetyltransferase 2B	Homo sapiens	31-34
9586579-3	1998	The active fraction containing CAF partially purified with PEG and ammonium sulfate results in marked activation of the complement system via the alternative pathway when interacted with CAF-depleted serum, whereas the active fraction or CAF-depleted serum alone does not activate the complement.	Ammonium Sulfate	67-83	lysine acetyltransferase 2B	Homo sapiens	31-34
9586579-3	1998	The active fraction containing CAF partially purified with PEG and ammonium sulfate results in marked activation of the complement system via the alternative pathway when interacted with CAF-depleted serum, whereas the active fraction or CAF-depleted serum alone does not activate the complement.	Ammonium Sulfate	67-83	lysine acetyltransferase 2B	Homo sapiens	187-190
9586579-3	1998	The active fraction containing CAF partially purified with PEG and ammonium sulfate results in marked activation of the complement system via the alternative pathway when interacted with CAF-depleted serum, whereas the active fraction or CAF-depleted serum alone does not activate the complement.	Ammonium Sulfate	67-83	lysine acetyltransferase 2B	Homo sapiens	187-190
9586579-8	1998	The relative activity of CAF is dramatically inhibited after reduction with 2-mercaptoethanol (2-ME), clearly demonstrating that CAF is sensitive to reduction with 2-ME and confirming a sulhydryl-dependent protein.	Mercaptoethanol	76-93	lysine acetyltransferase 2B	Homo sapiens	25-28
9586579-8	1998	The relative activity of CAF is dramatically inhibited after reduction with 2-mercaptoethanol (2-ME), clearly demonstrating that CAF is sensitive to reduction with 2-ME and confirming a sulhydryl-dependent protein.	Mercaptoethanol	76-93	lysine acetyltransferase 2B	Homo sapiens	129-132
9586579-8	1998	The relative activity of CAF is dramatically inhibited after reduction with 2-mercaptoethanol (2-ME), clearly demonstrating that CAF is sensitive to reduction with 2-ME and confirming a sulhydryl-dependent protein.	Mercaptoethanol	95-99	lysine acetyltransferase 2B	Homo sapiens	25-28
9586579-8	1998	The relative activity of CAF is dramatically inhibited after reduction with 2-mercaptoethanol (2-ME), clearly demonstrating that CAF is sensitive to reduction with 2-ME and confirming a sulhydryl-dependent protein.	Mercaptoethanol	95-99	lysine acetyltransferase 2B	Homo sapiens	129-132
9586579-8	1998	The relative activity of CAF is dramatically inhibited after reduction with 2-mercaptoethanol (2-ME), clearly demonstrating that CAF is sensitive to reduction with 2-ME and confirming a sulhydryl-dependent protein.	Mercaptoethanol	164-168	lysine acetyltransferase 2B	Homo sapiens	25-28
9586579-8	1998	The relative activity of CAF is dramatically inhibited after reduction with 2-mercaptoethanol (2-ME), clearly demonstrating that CAF is sensitive to reduction with 2-ME and confirming a sulhydryl-dependent protein.	Mercaptoethanol	164-168	lysine acetyltransferase 2B	Homo sapiens	129-132
9586579-9	1998	The optimal activity of CAF is observed in the range of 35-45 degrees C and its half-life at 37 degrees C is about 105 h. Furthermore, the relative activity of CAF increases and gradually approaches a plateau level with the increase of Mg2+ concentration.	magnesium ion	236-240	lysine acetyltransferase 2B	Homo sapiens	24-27
9586579-9	1998	The optimal activity of CAF is observed in the range of 35-45 degrees C and its half-life at 37 degrees C is about 105 h. Furthermore, the relative activity of CAF increases and gradually approaches a plateau level with the increase of Mg2+ concentration.	magnesium ion	236-240	lysine acetyltransferase 2B	Homo sapiens	160-163
9586579-10	1998	Obviously, complement activation induced by CAF depends on adequate Mg2+ concentration, confirming that this dependence is characteristic of the alternative pathway.	magnesium ion	68-72	lysine acetyltransferase 2B	Homo sapiens	44-47
9657010-14	1998	CONCLUSIONS: Based on these results, we consider the addition of high-dose toremifene to the CAF therapy to be useful in the treatment of advanced and recurrent breast cancer.	Toremifene	75-85	lysine acetyltransferase 2B	Homo sapiens	93-96
9492821-7	1998	Patients with rapidly progressing and/or endocrine-resistant tumor should be treated with anthracycline containing regimen such as CAF (cyclophosphamide, adriamycin, 5-fluorouracil).	Cyclophosphamide	136-152	lysine acetyltransferase 2B	Homo sapiens	131-134
9492821-7	1998	Patients with rapidly progressing and/or endocrine-resistant tumor should be treated with anthracycline containing regimen such as CAF (cyclophosphamide, adriamycin, 5-fluorouracil).	Doxorubicin	154-164	lysine acetyltransferase 2B	Homo sapiens	131-134
9492821-7	1998	Patients with rapidly progressing and/or endocrine-resistant tumor should be treated with anthracycline containing regimen such as CAF (cyclophosphamide, adriamycin, 5-fluorouracil).	Fluorouracil	166-180	lysine acetyltransferase 2B	Homo sapiens	131-134
9300134-10	1997	Meanwhile, under the condition of heating and dialysis experiments, it is obvious that the CAF is susceptible to heat and the dialysed serum sustains biological activity to destabilize liposome following dialysis against a buffer with Ca2+ and Mg2+, indicating that the CAF is not a type of low-molecular weight material but a serum protein.	magnesium ion	244-248	lysine acetyltransferase 2B	Homo sapiens	91-94
9341171-3	1997	Using either histone H1 or histone H3 as substrates, we find that preincubation with either acetyl-CoA or CoA stabilizes the acetyltransferase activities of PCAF, human GCN5 and an enzymatically active PCAF deletion mutant containing the C-terminal half of the protein.	Acetyl Coenzyme A	92-102	lysine acetyltransferase 2B	Homo sapiens	157-161
9341171-3	1997	Using either histone H1 or histone H3 as substrates, we find that preincubation with either acetyl-CoA or CoA stabilizes the acetyltransferase activities of PCAF, human GCN5 and an enzymatically active PCAF deletion mutant containing the C-terminal half of the protein.	Acetyl Coenzyme A	92-102	lysine acetyltransferase 2B	Homo sapiens	202-206
9341171-5	1997	Human GCN5 and the N-terminal deletion mutant of PCAF are stabilized equally well by preincubation with either CoA or acetyl-CoA, while intact PCAF is better stabilized by acetyl-CoA than by CoA.	Acetyl Coenzyme A	118-128	lysine acetyltransferase 2B	Homo sapiens	49-53
9341171-5	1997	Human GCN5 and the N-terminal deletion mutant of PCAF are stabilized equally well by preincubation with either CoA or acetyl-CoA, while intact PCAF is better stabilized by acetyl-CoA than by CoA.	Acetyl Coenzyme A	172-182	lysine acetyltransferase 2B	Homo sapiens	143-147
9163323-8	1997	This suggests that, in the context of the X2 element, CREB requires a close interaction with CAF to achieve both basal and cAMP-dependent transcriptional activation.	Cyclic AMP	123-127	lysine acetyltransferase 2B	Homo sapiens	93-96
9239420-1	1997	Previous studies have shown that cytosolic-free Ca2+ (Caf) increases to at least low micromolar concentrations during ATP depletion of isolated kidney proximal tubules.	Adenosine Triphosphate	118-121	lysine acetyltransferase 2B	Homo sapiens	54-57
9239420-3	1997	Now, we have used two low affinity Ca2+ fluorophores, mag-fura-2 (furaptra) and fura-2FF, to quantitate the full magnitude of Caf increase.	2-(2-(5-carboxy)oxazole)-5-hydroxy-6-aminobenzofuran-N,N,O-triacetic acid	54-64	lysine acetyltransferase 2B	Homo sapiens	126-129
9239420-3	1997	Now, we have used two low affinity Ca2+ fluorophores, mag-fura-2 (furaptra) and fura-2FF, to quantitate the full magnitude of Caf increase.	2-(2-(5-carboxy)oxazole)-5-hydroxy-6-aminobenzofuran-N,N,O-triacetic acid	66-74	lysine acetyltransferase 2B	Homo sapiens	126-129
9239420-3	1997	Now, we have used two low affinity Ca2+ fluorophores, mag-fura-2 (furaptra) and fura-2FF, to quantitate the full magnitude of Caf increase.	Fura F	80-88	lysine acetyltransferase 2B	Homo sapiens	126-129
9239420-7	1997	Considered in the context of the high degree of structural preservation of glycine-treated tubule cells during ATP depletion and the commonly assumed Ca2+ requirements for phospholipid hydrolysis, actin disassembly, and Ca2+-mediated structural damage, the remarkable elevations of Caf demonstrated here suggest an unexpected resistance to the deleterious effects of increased Caf during energy deprivation in the presence of glycine.	Glycine	75-82	lysine acetyltransferase 2B	Homo sapiens	282-285
9239420-7	1997	Considered in the context of the high degree of structural preservation of glycine-treated tubule cells during ATP depletion and the commonly assumed Ca2+ requirements for phospholipid hydrolysis, actin disassembly, and Ca2+-mediated structural damage, the remarkable elevations of Caf demonstrated here suggest an unexpected resistance to the deleterious effects of increased Caf during energy deprivation in the presence of glycine.	Glycine	75-82	lysine acetyltransferase 2B	Homo sapiens	377-380
11091585-1	1997	Thirty-two patients with advanced breast cancer refractory to combination chemotherapy with cyclophosphamide (CPA), doxorubicin (ADR) and 5-fluorouracil (5-EU) (CAF) were treated with the combination of mitomycin C, etoposide, doxifluridine and medroxyprogesterone acetate as second line therapy.	Fluorouracil	138-152	lysine acetyltransferase 2B	Homo sapiens	161-164
8625076-6	1995	In the early group, cyclophosphamide/methotrexate/5-fluorouracil (CMF) was administered to 32 patients, doxorubicin, cyclophosphamide or cyclophosphamide, doxorubicin, 5-fluorouracil (AC or CAF) to 6 patients, and other regimens to 4 patients; in the delayed group, CMF was given to 29 patients, CAF to 12 patients, and L-PAM/5-fluorouracil to 1 patient.	Cyclophosphamide	20-36	lysine acetyltransferase 2B	Homo sapiens	190-193
9087290-0	1997	[Antiemetic efficacy of granisetron in repeated CAF chemotherapy after breast cancer operation].	Granisetron	24-35	lysine acetyltransferase 2B	Homo sapiens	48-51
9087290-1	1997	The antiemetic efficacy of granisetron in repeated CAF chemotherapy after breast cancer operation was investigated.	Granisetron	27-38	lysine acetyltransferase 2B	Homo sapiens	51-54
9087290-8	1997	The antiemetic efficacy of granisetron decreased significantly by repeated CAF chemotherapy.	Granisetron	27-38	lysine acetyltransferase 2B	Homo sapiens	75-78
8625076-6	1995	In the early group, cyclophosphamide/methotrexate/5-fluorouracil (CMF) was administered to 32 patients, doxorubicin, cyclophosphamide or cyclophosphamide, doxorubicin, 5-fluorouracil (AC or CAF) to 6 patients, and other regimens to 4 patients; in the delayed group, CMF was given to 29 patients, CAF to 12 patients, and L-PAM/5-fluorouracil to 1 patient.	Cyclophosphamide	20-36	lysine acetyltransferase 2B	Homo sapiens	296-299
8625076-6	1995	In the early group, cyclophosphamide/methotrexate/5-fluorouracil (CMF) was administered to 32 patients, doxorubicin, cyclophosphamide or cyclophosphamide, doxorubicin, 5-fluorouracil (AC or CAF) to 6 patients, and other regimens to 4 patients; in the delayed group, CMF was given to 29 patients, CAF to 12 patients, and L-PAM/5-fluorouracil to 1 patient.	CMF regimen	66-69	lysine acetyltransferase 2B	Homo sapiens	190-193
8625076-6	1995	In the early group, cyclophosphamide/methotrexate/5-fluorouracil (CMF) was administered to 32 patients, doxorubicin, cyclophosphamide or cyclophosphamide, doxorubicin, 5-fluorouracil (AC or CAF) to 6 patients, and other regimens to 4 patients; in the delayed group, CMF was given to 29 patients, CAF to 12 patients, and L-PAM/5-fluorouracil to 1 patient.	CMF regimen	66-69	lysine acetyltransferase 2B	Homo sapiens	296-299
7955822-3	1994	In two studies, comprising 911 patients, the caffeine-containing analgesic consisted of a combination of 1000 mg acetaminophen and 130 mg caffeine (APAP/CAF).	Caffeine	45-53	lysine acetyltransferase 2B	Homo sapiens	153-156
8163567-10	1994	Transforming growth factor-beta (TGF-beta) and synovial cytokines (CAF) also increased lactate production.	Lactic Acid	87-94	lysine acetyltransferase 2B	Homo sapiens	67-70
8085859-0	1994	[Feasibility of adjuvant high-dose CAF (cyclophosphamide, adriamycin, 5-FU) therapy for primary breast cancer patients].	Cyclophosphamide	40-56	lysine acetyltransferase 2B	Homo sapiens	35-38
8085859-0	1994	[Feasibility of adjuvant high-dose CAF (cyclophosphamide, adriamycin, 5-FU) therapy for primary breast cancer patients].	Doxorubicin	58-68	lysine acetyltransferase 2B	Homo sapiens	35-38
8085859-0	1994	[Feasibility of adjuvant high-dose CAF (cyclophosphamide, adriamycin, 5-FU) therapy for primary breast cancer patients].	Fluorouracil	70-74	lysine acetyltransferase 2B	Homo sapiens	35-38
8107545-5	1993	Caffeine ingestion 1 h before the test (Bz-Caf) corrected the decrease in La max (La maxBz-Caf: 11.5 +/- 1.4 mmol.l-1) and E (EBz-Caf: 573 +/- 190 ng.l-1) but was unable to prevent the impairment of performance (PPBz-Caf: 625 +/- 68 W vs PPPla).	Caffeine	0-8	lysine acetyltransferase 2B	Homo sapiens	43-46
7513156-5	1994	S-nitrosylacetylpenicillamine (SNAP), an organic donor of NO, reversibly mimicked the effect of IL-1 and CAF on 35SO4(2-) incorporation.	S-Nitroso-N-Acetylpenicillamine	0-29	lysine acetyltransferase 2B	Homo sapiens	105-108
7513156-5	1994	S-nitrosylacetylpenicillamine (SNAP), an organic donor of NO, reversibly mimicked the effect of IL-1 and CAF on 35SO4(2-) incorporation.	S-Nitroso-N-Acetylpenicillamine	31-35	lysine acetyltransferase 2B	Homo sapiens	105-108
7513156-5	1994	S-nitrosylacetylpenicillamine (SNAP), an organic donor of NO, reversibly mimicked the effect of IL-1 and CAF on 35SO4(2-) incorporation.	35so4	112-117	lysine acetyltransferase 2B	Homo sapiens	105-108
7946592-1	1994	The usefulness of CAF [cyclophosphamide (CPA)/doxorubicin (ADR)/5-fluorouracil (5-FU)] + medroxyprogesterone acetate (MPA) therapy for advanced/recurrent breast cancer was studied in a randomised trial at 56 institutions.	Cyclophosphamide	23-39	lysine acetyltransferase 2B	Homo sapiens	18-21
8238541-1	1993	Increases of intracellular free Ca2+ (Caf) may mediate phospholipid hydrolysis and disintegration in energy-compromised cells; on the other hand, glycine and related amino acids preserve structure.	Phospholipids	55-67	lysine acetyltransferase 2B	Homo sapiens	38-41
8238541-3	1993	Incubation of isolated proximal tubules with antimycin A led to ATP depletion, delayed increases of Caf to micromolar levels, polyphosphoinositide (PPI) hydrolysis by phospholipase C, and generalized disintegration of cell structure.	Antimycin A	45-56	lysine acetyltransferase 2B	Homo sapiens	100-103
8238541-11	1993	Although damage by either factor occurs by distinct mechanisms, glycine also appears to have effects that suppress the deleterious effects of Ca2+ so long as Caf increases are not overwhelming.	Glycine	64-71	lysine acetyltransferase 2B	Homo sapiens	158-161
8238541-12	1993	Our results also suggest that the PPI have a major structural role, which may be compromised by Caf increase during ATP depletion.	Adenosine Triphosphate	116-119	lysine acetyltransferase 2B	Homo sapiens	96-99
7513156-1	1994	Slices of rabbit articular cartilage synthesized large quantities of nitric oxide (NO) following exposure to human recombinant interleukin-1 beta (hrIL-1 beta) or rabbit synovial cytokines (CAF).	Nitric Oxide	69-81	lysine acetyltransferase 2B	Homo sapiens	190-193
8107545-5	1993	Caffeine ingestion 1 h before the test (Bz-Caf) corrected the decrease in La max (La maxBz-Caf: 11.5 +/- 1.4 mmol.l-1) and E (EBz-Caf: 573 +/- 190 ng.l-1) but was unable to prevent the impairment of performance (PPBz-Caf: 625 +/- 68 W vs PPPla).	Caffeine	0-8	lysine acetyltransferase 2B	Homo sapiens	43-46
8107545-5	1993	Caffeine ingestion 1 h before the test (Bz-Caf) corrected the decrease in La max (La maxBz-Caf: 11.5 +/- 1.4 mmol.l-1) and E (EBz-Caf: 573 +/- 190 ng.l-1) but was unable to prevent the impairment of performance (PPBz-Caf: 625 +/- 68 W vs PPPla).	Caffeine	0-8	lysine acetyltransferase 2B	Homo sapiens	43-46
8339255-2	1993	Preclinical evidence suggests a similar potential role for IFN-alpha combined with cyclophosphamide, doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH), and 5-fluorouracil (CAF) in advanced adenocarcinoma of the breast.	Fluorouracil	165-179	lysine acetyltransferase 2B	Homo sapiens	181-184
8402636-1	1993	Caffeine (3,7-dihydro-1,3,7,-trimethyl-1H-purine-6,6-dione; CAF) is known to potentiate the cytotoxic effects of DNA damaging agents such as ionizing radiation and alkylating agents.	Caffeine	0-8	lysine acetyltransferase 2B	Homo sapiens	60-63
8402636-1	1993	Caffeine (3,7-dihydro-1,3,7,-trimethyl-1H-purine-6,6-dione; CAF) is known to potentiate the cytotoxic effects of DNA damaging agents such as ionizing radiation and alkylating agents.	3,7-dihydro-1,3,7,-trimethyl-1h-purine-6,6-dione	10-58	lysine acetyltransferase 2B	Homo sapiens	60-63
8402636-2	1993	In contrast, however, the cytotoxic and cytostatic activity of aromatic, DNA-intercalating, DNA topoisomerase II inhibitors such as Adriamycin, ellipticine, or mitoxantrone are diminished in the presence of CAF.	Doxorubicin	132-142	lysine acetyltransferase 2B	Homo sapiens	207-210
8402636-2	1993	In contrast, however, the cytotoxic and cytostatic activity of aromatic, DNA-intercalating, DNA topoisomerase II inhibitors such as Adriamycin, ellipticine, or mitoxantrone are diminished in the presence of CAF.	ellipticine	144-155	lysine acetyltransferase 2B	Homo sapiens	207-210
8402636-2	1993	In contrast, however, the cytotoxic and cytostatic activity of aromatic, DNA-intercalating, DNA topoisomerase II inhibitors such as Adriamycin, ellipticine, or mitoxantrone are diminished in the presence of CAF.	Mitoxantrone	160-172	lysine acetyltransferase 2B	Homo sapiens	207-210
8402636-6	1993	When added simultaneously with CAM or TPT, CAF prevented both effects.	Camptothecin	31-34	lysine acetyltransferase 2B	Homo sapiens	43-46
8402636-6	1993	When added simultaneously with CAM or TPT, CAF prevented both effects.	Topotecan	38-41	lysine acetyltransferase 2B	Homo sapiens	43-46
8402636-8	1993	The bathochromic and hypochromic shift in the absorption spectrum of the water soluble compound TPT upon addition of CAF indicated that CAF and TPT interact (stack) in a fashion similar to that previously observed for CAF and DNA intercalators.	Water	73-78	lysine acetyltransferase 2B	Homo sapiens	117-120
8402636-8	1993	The bathochromic and hypochromic shift in the absorption spectrum of the water soluble compound TPT upon addition of CAF indicated that CAF and TPT interact (stack) in a fashion similar to that previously observed for CAF and DNA intercalators.	Water	73-78	lysine acetyltransferase 2B	Homo sapiens	136-139
8402636-8	1993	The bathochromic and hypochromic shift in the absorption spectrum of the water soluble compound TPT upon addition of CAF indicated that CAF and TPT interact (stack) in a fashion similar to that previously observed for CAF and DNA intercalators.	Water	73-78	lysine acetyltransferase 2B	Homo sapiens	136-139
8402636-8	1993	The bathochromic and hypochromic shift in the absorption spectrum of the water soluble compound TPT upon addition of CAF indicated that CAF and TPT interact (stack) in a fashion similar to that previously observed for CAF and DNA intercalators.	Topotecan	96-99	lysine acetyltransferase 2B	Homo sapiens	117-120
8402636-8	1993	The bathochromic and hypochromic shift in the absorption spectrum of the water soluble compound TPT upon addition of CAF indicated that CAF and TPT interact (stack) in a fashion similar to that previously observed for CAF and DNA intercalators.	Topotecan	96-99	lysine acetyltransferase 2B	Homo sapiens	136-139
8402636-8	1993	The bathochromic and hypochromic shift in the absorption spectrum of the water soluble compound TPT upon addition of CAF indicated that CAF and TPT interact (stack) in a fashion similar to that previously observed for CAF and DNA intercalators.	Topotecan	96-99	lysine acetyltransferase 2B	Homo sapiens	136-139
8402636-8	1993	The bathochromic and hypochromic shift in the absorption spectrum of the water soluble compound TPT upon addition of CAF indicated that CAF and TPT interact (stack) in a fashion similar to that previously observed for CAF and DNA intercalators.	Topotecan	144-147	lysine acetyltransferase 2B	Homo sapiens	117-120
8402636-9	1993	Microcalorimetric measurements of TPT titration with CAF indicate an exothermic reaction between these compounds (the enthalpy change was delta H degree = -4.2 kcal/mol), which is consistent with a stacking model of CAF-TPT interaction.	Topotecan	34-37	lysine acetyltransferase 2B	Homo sapiens	53-56
8402636-9	1993	Microcalorimetric measurements of TPT titration with CAF indicate an exothermic reaction between these compounds (the enthalpy change was delta H degree = -4.2 kcal/mol), which is consistent with a stacking model of CAF-TPT interaction.	Topotecan	34-37	lysine acetyltransferase 2B	Homo sapiens	216-219
8402636-10	1993	Thus, the ability of CAF to protect HL-60 cells against the cell kinetic effects of CAM or TPT, as in the case of DNA intercalating topoisomerase II inhibitors, is most likely due to formation of complexes between CAF and these aromatic molecules, which result in reducing the effective concentration of the free form of these drugs available to the cells.	Camptothecin	84-87	lysine acetyltransferase 2B	Homo sapiens	21-24
8402636-10	1993	Thus, the ability of CAF to protect HL-60 cells against the cell kinetic effects of CAM or TPT, as in the case of DNA intercalating topoisomerase II inhibitors, is most likely due to formation of complexes between CAF and these aromatic molecules, which result in reducing the effective concentration of the free form of these drugs available to the cells.	Topotecan	91-94	lysine acetyltransferase 2B	Homo sapiens	21-24
8402636-10	1993	Thus, the ability of CAF to protect HL-60 cells against the cell kinetic effects of CAM or TPT, as in the case of DNA intercalating topoisomerase II inhibitors, is most likely due to formation of complexes between CAF and these aromatic molecules, which result in reducing the effective concentration of the free form of these drugs available to the cells.	Topotecan	91-94	lysine acetyltransferase 2B	Homo sapiens	214-217
1835850-7	1991	Among the 10-year survivors treated with Hexa-CAF, 50% had experienced progressive disease but were alive as a result of retreatment with a cisplatin regimen.	Cisplatin	140-149	lysine acetyltransferase 2B	Homo sapiens	46-49
1835850-13	1991	Combination chemotherapy with cisplatin can enhance survival by more than 10% at 5 and 10 years compared with the best treatment of the precisplatin era: Hexa-CAF.	Cisplatin	30-39	lysine acetyltransferase 2B	Homo sapiens	159-162
2102478-3	1990	The levels of serum calcium corrected by serum albumin (CaC), ionized calcium (CaF) and serum alkaline phosphatase (ALP) were significantly higher in the positive group than in the negative one.	Calcium	20-27	lysine acetyltransferase 2B	Homo sapiens	79-82
34791825-5	2022	By fate-mapping study, RNA velocity, and pseudotime analysis, existence of novel macrophage-lineage-derived CAF subset in the TME of Lewis lung carcinoma (LLC) model is confirmed, which is directly transited via MMT from M2-TAM in vivo and bone-marrow-derived macrophages (BMDM) in vitro.	tam	224-227	lysine acetyltransferase 2B	Homo sapiens	108-111
33766799-2	2021	Herein, an interpenetrating network (IPN) of collagen and alginate 3D culture system with tunable extracellular microstructure and mechanics is exploited as a tumor stroma proxy to study phenotypic plasticity of colorectal cancer-associated fibroblasts (CAF).	Alginates	58-66	lysine acetyltransferase 2B	Homo sapiens	223-252
33766799-2	2021	Herein, an interpenetrating network (IPN) of collagen and alginate 3D culture system with tunable extracellular microstructure and mechanics is exploited as a tumor stroma proxy to study phenotypic plasticity of colorectal cancer-associated fibroblasts (CAF).	Alginates	58-66	lysine acetyltransferase 2B	Homo sapiens	254-257
33766799-3	2021	In combination with Next Generation Sequencing (NGS) data analysis, we demonstrated that tuning the storage modulus of the IPN hydrogel between 49 and 419 Pa can trigger a reversible switch between an inflammatory (i-state, alpha-SMAlowIL-6high) and myofibroblastic (m-state, alpha-SMAhighIL-6low) state in CAF that is dependent on the polymer network confinement effect and ROS-HIF1-alpha mechanotransduction signaling axis.	ipn	123-126	lysine acetyltransferase 2B	Homo sapiens	307-310
34838998-6	2022	To identify potential therapeutic targets, we simulate enzyme knockouts and find that CAF-treated CRC cells are especially sensitive to inhibitions of hexokinase and glucose-6-phosphate, the rate limiting steps of glycolysis and oxidative PPP.	Glucose	166-173	lysine acetyltransferase 2B	Homo sapiens	86-89
34087002-1	2021	Retraction: "K-Ras-PI3K regulates H3K56ac through PCAF to elevate the occurrence and growth of liver cancer," by Xianrui Gao, Zhaoling Cheng, Haifeng Yuan, Haiwang Zhao, J Cell Physiol.	h3k56ac	34-41	lysine acetyltransferase 2B	Homo sapiens	50-54
34820002-11	2022	The ROCK1 inhibitor Y-27632 attenuated the motility of tumor cells in ECC-1 and CAF co-cultures.	Y 27632	20-27	lysine acetyltransferase 2B	Homo sapiens	80-83
34555274-0	2021	P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer.	Lysine	68-74	lysine acetyltransferase 2B	Homo sapiens	0-26
34555274-0	2021	P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer.	Lysine	68-74	lysine acetyltransferase 2B	Homo sapiens	28-32
34555274-10	2021	RESULTS: Fascin directly interacted and colocalized with PCAF in the cytoplasm and was acetylated at lysine 471 (K471) by PCAF.	Lysine	101-107	lysine acetyltransferase 2B	Homo sapiens	122-126
34583978-5	2021	Interestingly, GPC1 was expressed on CAF in PDAC.	pdac	44-48	lysine acetyltransferase 2B	Homo sapiens	37-40
34583978-6	2021	We generated a GPC1 antibody-drug conjugate conjugated with monomethyl auristatin E (GPC1-ADC(MMAE)) and evaluated its preclinical antitumor activity by targeting GPC1-positive CAF and cancer cells in PDAC.	monomethyl auristatin E	60-83	lysine acetyltransferase 2B	Homo sapiens	177-180
34318362-3	2021	The aim of the present study was to evaluate outcomes of VAAFT for a series of CAF.	vaaft	57-62	lysine acetyltransferase 2B	Homo sapiens	79-82
34709252-6	2021	Calculations for the dissociation process of CaF(H2O)6+ show a dramatic energy increase going from SSIP to free Ca2+ and F-, ascribed to the surprisingly long-range electrostatic attraction between Ca2+ and F- rather than to special F H interactions.	Water	49-52	lysine acetyltransferase 2B	Homo sapiens	45-48
34709252-7	2021	The energy increase results in the estimated association constant of CaF+ being larger than that previously measured using fluoride ion selective electrodes.	Fluorides	123-131	lysine acetyltransferase 2B	Homo sapiens	69-72
34139285-8	2021	Functionally, CAF-induced M-MDSCs promoted drug resistance of tumor cells upon cisplatin treatment.	Cisplatin	79-88	lysine acetyltransferase 2B	Homo sapiens	14-17
34692770-14	2021	GSEA revealed that epithelial-mesenchymal transition (EMT), TGF-beta signaling, hypoxia, and angiogenesis gene sets were significantly enriched in high-CAF-risk group patients.	gsea	0-4	lysine acetyltransferase 2B	Homo sapiens	152-155
34126285-0	2021	From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity.	triazolophthalazines	5-25	lysine acetyltransferase 2B	Homo sapiens	118-122
34543976-3	2021	The elimination of two model PPCPs, primidone (PRM) and caffeine (CAF), by the co-exposure of UV and free chlorine was investigated to elucidate the impact of EfOM.	Caffeine	56-64	lysine acetyltransferase 2B	Homo sapiens	66-69
34543976-3	2021	The elimination of two model PPCPs, primidone (PRM) and caffeine (CAF), by the co-exposure of UV and free chlorine was investigated to elucidate the impact of EfOM.	Chlorine	106-114	lysine acetyltransferase 2B	Homo sapiens	66-69
34543976-5	2021	The decay of CAF was dominated by ClO  under all conditions.	Hypochlorous Acid	34-37	lysine acetyltransferase 2B	Homo sapiens	13-16
34543976-7	2021	Presence of EfOM isolate remarkably inhibited the decay of PRM and CAF by preferentially scavenging RCS and particularly ClO .	efom	12-16	lysine acetyltransferase 2B	Homo sapiens	67-70
34543976-7	2021	Presence of EfOM isolate remarkably inhibited the decay of PRM and CAF by preferentially scavenging RCS and particularly ClO .	Hypochlorous Acid	121-124	lysine acetyltransferase 2B	Homo sapiens	67-70
34565388-1	2021	BACKGROUND: Carbohydrate (CHO) and caffeine (CAF) mouth rinsing have been shown to enhance endurance and sprint performance.	Caffeine	35-43	lysine acetyltransferase 2B	Homo sapiens	45-48
34126285-2	2021	In this study, we report the bioisosteric modification of the first reported potent PCAF bromodomain inhibitor, L-45 to its triazoloquinazoline bioisosteres.	L-Moses	112-116	lysine acetyltransferase 2B	Homo sapiens	84-88
34099638-0	2021	Reduced hyaluronan cross-linking induces breast cancer malignancy in a CAF-dependent manner.	Hyaluronic Acid	8-18	lysine acetyltransferase 2B	Homo sapiens	71-74
34208665-6	2021	Functional changes in HMF3S-CAF calcium signalling pathways were assessed using a fluorescent indicator, gene expression, gene-silencing and pharmacological approaches.	Calcium	32-39	lysine acetyltransferase 2B	Homo sapiens	28-31
34208665-7	2021	HMF3S-CAF cells demonstrated functionally altered calcium influx pathways with reduced store-operated calcium entry.	Calcium	50-57	lysine acetyltransferase 2B	Homo sapiens	6-9
34208665-7	2021	HMF3S-CAF cells demonstrated functionally altered calcium influx pathways with reduced store-operated calcium entry.	Calcium	102-109	lysine acetyltransferase 2B	Homo sapiens	6-9
35621145-9	2022	It is suggested that curcumin may be a suitable natural product which may be used to overcome chemoresistance by inhibiting the CAF-induced activation of the JAK/STAT3 signaling pathway in GC.	Curcumin	21-29	lysine acetyltransferase 2B	Homo sapiens	128-131
34094963-5	2021	The regulation of CAF/TAM communication and/or their differentiation could be of high impact for improving the future targeted treatment strategies.	tam	22-25	lysine acetyltransferase 2B	Homo sapiens	18-21
35621145-6	2022	The experimental models revealed that curcumin abrogated the CAF-mediated activation of the JAK/STAT3 signaling pathway in GC cells.	Curcumin	38-46	lysine acetyltransferase 2B	Homo sapiens	61-64
34079223-12	2021	Docking results revealed that among the selected oncotargets, Chk1, CD73, Nrf2, PCAF and AT tip60 were more vulnerable to wedelolactone than their respective standard inhibitors.	wedelolactone	122-135	lysine acetyltransferase 2B	Homo sapiens	80-84
34124543-9	2021	According to CFD analysis based on CCTA, low wall shear stress and a high focal oscillatory shear index were observed at the ostial sites of aneurysmal sacs in the CAF.	ccta	35-39	lysine acetyltransferase 2B	Homo sapiens	164-167
35607950-4	2022	Here, we introduce the novel non-canonical amino acid (ncAA) p-cyanoacetylene-L-Phe (pCAF), which facilitates spontaneous, co-translational cyclization through Michael addition with cysteine under physiological conditions.	(ncaa) p-cyanoacetylene-l-phe	54-83	lysine acetyltransferase 2B	Homo sapiens	85-89
35607950-4	2022	Here, we introduce the novel non-canonical amino acid (ncAA) p-cyanoacetylene-L-Phe (pCAF), which facilitates spontaneous, co-translational cyclization through Michael addition with cysteine under physiological conditions.	Cysteine	182-190	lysine acetyltransferase 2B	Homo sapiens	85-89
35545049-6	2022	PARP inhibitors, such as olaparib, mimick lactate in the reduction of stromal p62 levels, as well as the subsequent stromal activation both in vitro and in vivo, which suggests that therapies using olaparib would benefit from strategies aimed at inhibiting CAF activity.	olaparib	25-33	lysine acetyltransferase 2B	Homo sapiens	257-260
35507695-7	2022	Caffeine (38 wt %) was incorporated in CAF@MIL-53(Al) microcapsules, as analyzed by TGA and corroborated by GC/MS and UV-vis after additive extraction.	Caffeine	0-8	lysine acetyltransferase 2B	Homo sapiens	39-49
35507695-8	2022	CAF@MIL-53(Al) microcapsules showed a controlled release of caffeine during 6 days at 25  C (up to 22% of the initial caffeine).	Aluminum	11-13	lysine acetyltransferase 2B	Homo sapiens	0-10
35507695-8	2022	CAF@MIL-53(Al) microcapsules showed a controlled release of caffeine during 6 days at 25  C (up to 22% of the initial caffeine).	Caffeine	60-68	lysine acetyltransferase 2B	Homo sapiens	0-10
35507695-8	2022	CAF@MIL-53(Al) microcapsules showed a controlled release of caffeine during 6 days at 25  C (up to 22% of the initial caffeine).	Caffeine	118-126	lysine acetyltransferase 2B	Homo sapiens	0-10
35545049-6	2022	PARP inhibitors, such as olaparib, mimick lactate in the reduction of stromal p62 levels, as well as the subsequent stromal activation both in vitro and in vivo, which suggests that therapies using olaparib would benefit from strategies aimed at inhibiting CAF activity.	Lactic Acid	42-49	lysine acetyltransferase 2B	Homo sapiens	257-260
35545049-6	2022	PARP inhibitors, such as olaparib, mimick lactate in the reduction of stromal p62 levels, as well as the subsequent stromal activation both in vitro and in vivo, which suggests that therapies using olaparib would benefit from strategies aimed at inhibiting CAF activity.	olaparib	198-206	lysine acetyltransferase 2B	Homo sapiens	257-260
35436422-5	2022	The increase in plasma lactate concentration was more pronounced in NaHCO3 + CAF than in NaHCO3 and placebo (P < .05).	Lactic Acid	23-30	lysine acetyltransferase 2B	Homo sapiens	77-80
35565206-5	2022	The cancer cell-CAF interaction in the CIPCO promoted epithelial-mesenchymal transition of cancer cells, which was reversed by CAF inhibition using all-trans retinoic acid.	Tretinoin	158-171	lysine acetyltransferase 2B	Homo sapiens	16-19
35565206-5	2022	The cancer cell-CAF interaction in the CIPCO promoted epithelial-mesenchymal transition of cancer cells, which was reversed by CAF inhibition using all-trans retinoic acid.	Tretinoin	158-171	lysine acetyltransferase 2B	Homo sapiens	127-130
35436422-5	2022	The increase in plasma lactate concentration was more pronounced in NaHCO3 + CAF than in NaHCO3 and placebo (P < .05).	Sodium Bicarbonate	68-74	lysine acetyltransferase 2B	Homo sapiens	77-80
35436422-6	2022	Mean ventilation and carbon dioxide production were higher in NaHCO3 + CAF compared to NaHCO3 and placebo (P < .05).	Carbon Dioxide	21-35	lysine acetyltransferase 2B	Homo sapiens	71-74
35436422-7	2022	The PO and anaerobic power output were increased at the beginning of the 4-km TT (P < .05) in NaHCO3 + CAF compared to the other two conditions, resulting in an improved overall performance (P < .05).	Sodium Bicarbonate	94-100	lysine acetyltransferase 2B	Homo sapiens	103-106
35436422-8	2022	Conclusion: NaHCO3 + CAF results in a higher PO and increased anaerobic contribution and respiratory parameters during a 4-km cycling TT.	6-thiotheophylline	134-136	lysine acetyltransferase 2B	Homo sapiens	21-24
35105690-2	2022	Here we show that the tumor-promoting lipid mediator prostaglandin E2 (PGE2) plays a paradoxical role in CAF activation and tumor progression.	Dinoprostone	53-69	lysine acetyltransferase 2B	Homo sapiens	105-108
35403781-5	2022	Gene expression of HDAC1, HDAC2, SIRT1, MTA1, KAT2B, KAT6A, KAT6B, and BRD4 indicated the cisplatin activates the epigenetic machinery.	Cisplatin	90-99	lysine acetyltransferase 2B	Homo sapiens	46-51
35105690-2	2022	Here we show that the tumor-promoting lipid mediator prostaglandin E2 (PGE2) plays a paradoxical role in CAF activation and tumor progression.	Dinoprostone	71-75	lysine acetyltransferase 2B	Homo sapiens	105-108
35105690-3	2022	Restricting PGE2 signaling via knockout of microsomal prostaglandin E synthase-1 (mPGES-1) in PyMT mice or of the prostanoid E receptor 3 (EP3) in CAFs stunted mammary carcinoma growth associated with strong CAF proliferation.	Dinoprostone	12-16	lysine acetyltransferase 2B	Homo sapiens	208-211
35326670-0	2022	Bete Noire of Chemotherapy and Targeted Therapy: CAF-Mediated Resistance.	bete noire	0-10	lysine acetyltransferase 2B	Homo sapiens	49-52
35371970-4	2022	MiR-138 mimics and inhibitors were used to functionally investigate the role of miR-138 on CAF phenotype and the resulting change in their ability to support OSCC invasion.	mir-138	0-7	lysine acetyltransferase 2B	Homo sapiens	91-94
35371970-4	2022	MiR-138 mimics and inhibitors were used to functionally investigate the role of miR-138 on CAF phenotype and the resulting change in their ability to support OSCC invasion.	mir-138	80-87	lysine acetyltransferase 2B	Homo sapiens	91-94
35045883-3	2022	Here, we explored the role of circRNAs in CAF-induced GEM resistance in PDAC.	gemcitabine	54-57	lysine acetyltransferase 2B	Homo sapiens	42-45
35045883-13	2022	CONCLUSIONS: The circFARP1/CAV1/miR-660-3p/LIF axis is critical for CAF-induced GEM resistance in PDAC.	gemcitabine	80-83	lysine acetyltransferase 2B	Homo sapiens	68-71