PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 2474457-2 1989 Desmin, GFAP, vimentin, peripherin and the lightest neurofilament protein (NF-L) were cleaved into carboxy- and amino-terminal halves by N-chlorosuccinimide at their unique trytophan residue. N-chlorosuccinimide 137-156 neurofilament light chain Homo sapiens 52-73 2478022-10 1989 However, NF-H, NF-M, and NF-L were expressed throughout the cell cycle in dual parameter studies of D283 cells labeled with an antibody and propidium iodide. Propidium 140-156 neurofilament light chain Homo sapiens 25-29 2474457-2 1989 Desmin, GFAP, vimentin, peripherin and the lightest neurofilament protein (NF-L) were cleaved into carboxy- and amino-terminal halves by N-chlorosuccinimide at their unique trytophan residue. Tryptophan 173-182 neurofilament light chain Homo sapiens 52-73 2474457-2 1989 Desmin, GFAP, vimentin, peripherin and the lightest neurofilament protein (NF-L) were cleaved into carboxy- and amino-terminal halves by N-chlorosuccinimide at their unique trytophan residue. Tryptophan 173-182 neurofilament light chain Homo sapiens 75-79 2474457-2 1989 Desmin, GFAP, vimentin, peripherin and the lightest neurofilament protein (NF-L) were cleaved into carboxy- and amino-terminal halves by N-chlorosuccinimide at their unique trytophan residue. N-chlorosuccinimide 137-156 neurofilament light chain Homo sapiens 75-79 2925792-3 1989 The core component, NF-L, was stoichiometrically labeled at cysteine 321 with fluorescein, coumarin, or biotin-maleimide to produce assembly-competent fluorescent or biotinylated derivatives, respectively. Cysteine 60-68 neurofilament light chain Homo sapiens 20-24 2925792-3 1989 The core component, NF-L, was stoichiometrically labeled at cysteine 321 with fluorescein, coumarin, or biotin-maleimide to produce assembly-competent fluorescent or biotinylated derivatives, respectively. Fluorescein 78-89 neurofilament light chain Homo sapiens 20-24 2925792-3 1989 The core component, NF-L, was stoichiometrically labeled at cysteine 321 with fluorescein, coumarin, or biotin-maleimide to produce assembly-competent fluorescent or biotinylated derivatives, respectively. coumarin 91-99 neurofilament light chain Homo sapiens 20-24 2925792-3 1989 The core component, NF-L, was stoichiometrically labeled at cysteine 321 with fluorescein, coumarin, or biotin-maleimide to produce assembly-competent fluorescent or biotinylated derivatives, respectively. maleimide-biotin 104-120 neurofilament light chain Homo sapiens 20-24 2925792-4 1989 Using coumarin-labeled NF-L as fluorescence donor and fluorescein-labeled NF-L as the fluorescence acceptor, assembly of NF filaments was induced by rapidly raising the NaCl concentration to 170 mM, and the kinetics was followed by the decrease in the donor fluorescence. coumarin 6-14 neurofilament light chain Homo sapiens 23-27 2925792-4 1989 Using coumarin-labeled NF-L as fluorescence donor and fluorescein-labeled NF-L as the fluorescence acceptor, assembly of NF filaments was induced by rapidly raising the NaCl concentration to 170 mM, and the kinetics was followed by the decrease in the donor fluorescence. Fluorescein 54-65 neurofilament light chain Homo sapiens 74-78 2925792-4 1989 Using coumarin-labeled NF-L as fluorescence donor and fluorescein-labeled NF-L as the fluorescence acceptor, assembly of NF filaments was induced by rapidly raising the NaCl concentration to 170 mM, and the kinetics was followed by the decrease in the donor fluorescence. Sodium Chloride 169-173 neurofilament light chain Homo sapiens 23-27 2925792-4 1989 Using coumarin-labeled NF-L as fluorescence donor and fluorescein-labeled NF-L as the fluorescence acceptor, assembly of NF filaments was induced by rapidly raising the NaCl concentration to 170 mM, and the kinetics was followed by the decrease in the donor fluorescence. Sodium Chloride 169-173 neurofilament light chain Homo sapiens 74-78 2845017-6 1988 NFL and, to a much greater degree, NFM became labeled following incubation of intact neurons with 32P-PO4. 32p-po4 98-105 neurofilament light chain Homo sapiens 0-3 2493000-6 1989 As judged by immunofluorescence localization and by the alteration in the solubility of the endogenous vimentin filaments, filaments containing NF-L appeared to be copolymers with vimentin. copolymers 164-174 neurofilament light chain Homo sapiens 144-148 2445939-2 1987 Electrophoretically purified NF-H (200 kDa), NF-M (160 kDa), and NF-L (68 kDa) of human origin contained 24, 18, and 4 mol phosphate/mol protein, whereas bovine NF contained 53, 23, and 5 mol phosphate/mol protein, respectively. Phosphates 123-132 neurofilament light chain Homo sapiens 65-69 3734790-4 1986 Chemical phosphate analysis showed that as isolated NF-H, NF-M, and NF-L contained about 22, 11, and 3 mol phosphate/mol polypeptide, respectively. Phosphates 9-18 neurofilament light chain Homo sapiens 68-72 3734790-4 1986 Chemical phosphate analysis showed that as isolated NF-H, NF-M, and NF-L contained about 22, 11, and 3 mol phosphate/mol polypeptide, respectively. Phosphates 107-116 neurofilament light chain Homo sapiens 68-72 34020161-5 2021 Glutamate (Glu) levels were lower in the cART naive patients than in healthy controls and were inversely correlated with plasma levels of NfL. Glutamic Acid 0-9 neurofilament light chain Homo sapiens 138-141 3461781-4 1986 The amount of phosphate incorporated per molecule was higher for NF 200 than for NF 145 and NF 68. Phosphates 14-23 neurofilament light chain Homo sapiens 92-97 3513600-3 1986 When alcohol-fixed paraffin-embedded material was used, neurofilament staining was weaker and the fixation procedure appeared to destroy the epitopes recognized by the NF-L antibodies preferentially. Alcohols 5-12 neurofilament light chain Homo sapiens 168-172 3513600-3 1986 When alcohol-fixed paraffin-embedded material was used, neurofilament staining was weaker and the fixation procedure appeared to destroy the epitopes recognized by the NF-L antibodies preferentially. Paraffin 19-27 neurofilament light chain Homo sapiens 168-172 2416873-3 1986 The silver binding sites in NF-L are located in a carboxy-terminal 12-Kd chymotrypsin fragment, a highly charged, unique domain of NF. Silver 4-10 neurofilament light chain Homo sapiens 28-32 34020161-5 2021 Glutamate (Glu) levels were lower in the cART naive patients than in healthy controls and were inversely correlated with plasma levels of NfL. Glutamic Acid 0-3 neurofilament light chain Homo sapiens 138-141 33783299-7 2021 RESULTS: Ketamine-dependent patients had significantly higher NFL levels compared to controls (p<.001). Ketamine 9-17 neurofilament light chain Homo sapiens 62-65 33783299-9 2021 Subsequent group comparisons showed that specifically ketamine-dependent patients with a lifetime history of MDD had significantly increased NFL levels than those without (p<.05). Ketamine 54-62 neurofilament light chain Homo sapiens 141-144 33783299-11 2021 The pronounced increase of NFL levels in the MDD subgroup warrants further investigation of a potential neuroaxonal vulnerability of depressed patients to ketamine. Ketamine 155-163 neurofilament light chain Homo sapiens 27-30 33889121-7 2021 The numbers of lobar CMBs significantly increased the CSF levels of NFL in the total AD patients, additionally, among AD subtypes, the CSF levels of NFL in lvPPA predominantly were higher by increasing number of lobar CMBs. cmbs 21-25 neurofilament light chain Homo sapiens 68-71 33870790-8 2022 In univariable analysis, having >=2 iron rims (vs 0) was associated with increased CSF CHI3L1 levels (beta = 1.41; 95% confidence interval (CI) = 1.10-1.79; p < 0.01) and serum NfL levels (beta = 2.30; 95% CI = 1.47-3.60; p < 0.01). Iron 36-40 neurofilament light chain Homo sapiens 177-180 33889121-7 2021 The numbers of lobar CMBs significantly increased the CSF levels of NFL in the total AD patients, additionally, among AD subtypes, the CSF levels of NFL in lvPPA predominantly were higher by increasing number of lobar CMBs. cmbs 218-222 neurofilament light chain Homo sapiens 68-71 33889121-7 2021 The numbers of lobar CMBs significantly increased the CSF levels of NFL in the total AD patients, additionally, among AD subtypes, the CSF levels of NFL in lvPPA predominantly were higher by increasing number of lobar CMBs. cmbs 218-222 neurofilament light chain Homo sapiens 149-152 32810755-4 2020 We found that the concentration of NfL in CSF, but not in plasma, was increased in response to Abeta pathology in CU subjects. UNII-042A8N37WH 95-100 neurofilament light chain Homo sapiens 35-38 33639572-3 2021 To determine whether serum NFL at baseline in de novo PD predicts motor decline, differentially impacts specific motor features, predicts cognitive decline, and predicts loss of dopamine terminals, here we evaluated 376 de novo PD patients from the PPMI database and analyzed the effect of baseline serum NFL levels on progression over eight years of motor impairment measured with the UPDRS, cognitive function measured with the MoCA, and putamen dopamine transporter (DAT) binding ratio measured with DaTscan. Dopamine 178-186 neurofilament light chain Homo sapiens 27-30 33639572-4 2021 In longitudinal mixed effects models that controlled for age, gender, disease duration, and levodopa equivalent drug dose, higher levels of serum NFL at baseline were associated with greater increases of UPDRS-III and total UPDRS scores, with greater worsening of postural instability and gait disorder (PIGD) scores but not tremor scores over time. Levodopa 92-100 neurofilament light chain Homo sapiens 146-149 33706250-10 2021 There was also a significant association between lower cortical R2*, suggestive of reduced myelin or iron, and higher CSF NfL in the frontal lobe and the parieto-occipital cortices. Iron 101-105 neurofilament light chain Homo sapiens 122-125 33635141-3 2021 OBJECTIVE: To evaluate whether ibudilast 100 mg/day alters serum and cerebrospinal fluid (CSF) levels of NfL in progressive MS. METHODS: In a protocol-defined exploratory analysis from a 2-year, phase 2 clinical trial of ibudilast in progressive MS (NCT01982942), serum samples were collected from 239 subjects and a subset contributed CSF and assayed using single-molecule assay (SIMOA) immunoassay. ibudilast 31-40 neurofilament light chain Homo sapiens 105-108 33550636-14 2021 ABC and CSF NEFL correlate with UBDRS seizure score, reflecting the role of seizures in the neurodegenerative process. ubdrs 32-37 neurofilament light chain Homo sapiens 12-16 32896023-7 2021 Significant correlations between NFL and insulin, TC, HDL-C, TG, VLDL-C, and BMI were found. Thioguanine 61-63 neurofilament light chain Homo sapiens 33-36 32932412-9 2020 Among PWH, higher CSF neopterin was most closely associated with higher NFL. Neopterin 22-31 neurofilament light chain Homo sapiens 72-75 33492760-12 2021 Baseline NfL was associated with number of intravenous steroid infusions (mean = 0.2; SD = 3.0, P = 0.013), whereas the average of baseline and 12 months NfL values related to inpatient stays at 12 months (mean = 0.2; SD = 3.0 P = 0.053). Steroids 55-62 neurofilament light chain Homo sapiens 9-12 33593918-5 2021 Assembled IFs revealed spectra overlapping with those observed for beta-strand-enriched polymers formed from the isolated NFL and desmin head domains. Polymers 88-96 neurofilament light chain Homo sapiens 122-125 33070094-6 2021 We found increases of between 20% and 41% in WMH volume per 1SD increase in NFL in significant memory concern, early mild cognitive impairment, late mild cognitive impairment, and Alzheimer"s disease groups (p < 0.02). CHEMBL569412 60-63 neurofilament light chain Homo sapiens 76-79 32333051-4 2020 Since increasing clinical evidence supports the potential use of neurofilament light chain (NfL) as a biomarker of axonal injury, in this study we measured serum NfL levels in animals chronically treated with cisplatin (CDDP) and paclitaxel (PTX), two antineoplastic drugs with different neuronal targets. Cisplatin 209-218 neurofilament light chain Homo sapiens 162-165 32868793-8 2020 Moreover, multiple comparison analysis showed highly significant levels of beta-III tubulin (P = 0.0002), Nf-L (P = 0.0403) and GFAP (P < 0.015) in the subgroup of CSZ clozapine-treated. csz 164-167 neurofilament light chain Homo sapiens 106-110 32868793-8 2020 Moreover, multiple comparison analysis showed highly significant levels of beta-III tubulin (P = 0.0002), Nf-L (P = 0.0403) and GFAP (P < 0.015) in the subgroup of CSZ clozapine-treated. Clozapine 168-177 neurofilament light chain Homo sapiens 106-110 33055205-8 2020 Higher 8-oxo-dG correlated with markers of AD-related neurodegeneration including lower CSF Abeta-42 (r = -0.34; p = 0.012) and higher CSF NFL (r = 0.39; p = 0.0091) and total tau (r = 0.6696; p < 0.0001). 8-ohdg 7-15 neurofilament light chain Homo sapiens 139-142 32982935-3 2020 Results: The median NFL levels in the CSF of the sALS, OCNSD, IMPN, NIMPN, and HC groups were 6510, 5372, 4320, 1477, and 756 pg/mL, respectively. nimpn 68-73 neurofilament light chain Homo sapiens 20-23 32425877-3 2020 Objectives: To examine the association between physiological variations in serum 25(OH)D and NfL levels in RRMS patients before and during disease modifying therapy (DMT). 25(oh)d 81-88 neurofilament light chain Homo sapiens 93-96 32300060-9 2020 Associations with NfL concentrations at year 11 corroborated these findings-a 50-nmol/L higher mean 25(OH)D in the first 2 years was associated with 20% lower NfL (95% CI: -36% to 0%), whereas smokers had 20% higher NfL levels than nonsmokers (95% CI: 2%-40%). 25(oh)d 100-107 neurofilament light chain Homo sapiens 18-21 32300060-9 2020 Associations with NfL concentrations at year 11 corroborated these findings-a 50-nmol/L higher mean 25(OH)D in the first 2 years was associated with 20% lower NfL (95% CI: -36% to 0%), whereas smokers had 20% higher NfL levels than nonsmokers (95% CI: 2%-40%). 25(oh)d 100-107 neurofilament light chain Homo sapiens 159-162 32300060-9 2020 Associations with NfL concentrations at year 11 corroborated these findings-a 50-nmol/L higher mean 25(OH)D in the first 2 years was associated with 20% lower NfL (95% CI: -36% to 0%), whereas smokers had 20% higher NfL levels than nonsmokers (95% CI: 2%-40%). 25(oh)d 100-107 neurofilament light chain Homo sapiens 159-162 32425877-7 2020 Associations between 25(OH)D and NfL levels were analyzed with linear regression models for the whole study period and the periods before and during IFN-beta treatment. 25(oh)d 21-28 neurofilament light chain Homo sapiens 33-36 32290514-7 2020 Our aim was to assess whether there is an association of the neurodegenerative biomarker NFL with the markers of neuroinflammation, e.g., kynurenine metabolites and neopterin, in the cerebrospinal fluid (CSF). Kynurenine 138-148 neurofilament light chain Homo sapiens 89-92 32290514-7 2020 Our aim was to assess whether there is an association of the neurodegenerative biomarker NFL with the markers of neuroinflammation, e.g., kynurenine metabolites and neopterin, in the cerebrospinal fluid (CSF). Neopterin 165-174 neurofilament light chain Homo sapiens 89-92 32290514-10 2020 Significant correlations were found between NFL, neopterin, and QUIN, and between kynurenine and neopterin. Quinolinic Acid 64-68 neurofilament light chain Homo sapiens 44-47 31657006-4 2020 We explored whether 48-week high-dose vitamin D3 supplements were associated with lower circulating NfL levels. Cholecalciferol 38-48 neurofilament light chain Homo sapiens 100-103 31967119-8 2020 Together with the complexation results by titration, the crystal structures of an endocyclic mercury(ii) perchlorate complex and an exocyclic mercury(ii) iodide complex revealed that the anion-controlled mercury(ii) sensing by L2 arises from the endo- and exo-coordination modes depending on the anion coordinating ability, which induces either metal-receptor/fluorophore binding (Hg-Ntert and Hg-Nfl) or no binding. Iodides 154-160 neurofilament light chain Homo sapiens 397-400 31394988-1 2020 OBJECTIVE: The primary objective of this preliminary study was to examine the impact of NFL play on interregional functional connectivity between two brain regions, the supramarginal gyrus (SMG) and the thalamus, identified as having higher binding of [11C]DPA-713 in NFL players. Carbon-11 253-256 neurofilament light chain Homo sapiens 88-91 31394988-1 2020 OBJECTIVE: The primary objective of this preliminary study was to examine the impact of NFL play on interregional functional connectivity between two brain regions, the supramarginal gyrus (SMG) and the thalamus, identified as having higher binding of [11C]DPA-713 in NFL players. dpa 257-260 neurofilament light chain Homo sapiens 88-91 31350854-2 2020 Primary aim was to measure NFL in plasma samples of untreated patients with primary (PP) and secondary (SP) progressive MS and to correlate them with disability, disease severity, and prior/subsequent disability progression. TFF2 protein, human 104-106 neurofilament light chain Homo sapiens 27-30 32310173-5 2020 Plasma NFL concentration had a moderately strong correlation with WMH at baseline (r = 0.17, p < 0.001). 1-methyl-1H-1,2,3-triazole 66-69 neurofilament light chain Homo sapiens 7-10 32538843-8 2020 7-KC modulated the association between AxD and NfL in the corpus callosum splenium (B = 39.39, p = 0.017), genu (B = 68.64, p = 0.000), and fornix (B = 10.97, p = 0.000). AXD 39-42 neurofilament light chain Homo sapiens 47-50 31611264-7 2019 After 12 months of DMF treatment, NFL concentration decreased by 73%, 69% and 55% in the CSF, serum and plasma (p<0.0001, respectively). Dimethyl Fumarate 19-22 neurofilament light chain Homo sapiens 34-37 31552549-2 2020 METHODS: We measured serum NfL in 46 SMA patients at baseline and over 14 months of treatment with the antisense-oligonucleotide (ASO) nusinersen using the ultrasensitive single molecule array (Simoa) technology. Oligonucleotides 113-128 neurofilament light chain Homo sapiens 27-30 31123861-0 2019 NFL is a marker of treatment response in children with SMA treated with nusinersen. nusinersen 72-82 neurofilament light chain Homo sapiens 0-3 31072225-9 2019 After adjusting for acknowledged TBI outcome predictors, GFAP and NF-L added most independent information to predict favorable/unfavorable GOS, improving the model from 0.38 to 0.51 pseudo-R2. D-Glucitol-1,6-bisphosphate 139-142 neurofilament light chain Homo sapiens 66-70 31601232-5 2019 RESULTS: A positive correlation between NFL and the kynurenine to tryptophan ratio (K/T) reflecting indoleamine 2,3-dioxygenase activity was observed (r = .451, p < .0001). Kynurenine 52-62 neurofilament light chain Homo sapiens 40-43 31601232-5 2019 RESULTS: A positive correlation between NFL and the kynurenine to tryptophan ratio (K/T) reflecting indoleamine 2,3-dioxygenase activity was observed (r = .451, p < .0001). Tryptophan 66-76 neurofilament light chain Homo sapiens 40-43 31601232-5 2019 RESULTS: A positive correlation between NFL and the kynurenine to tryptophan ratio (K/T) reflecting indoleamine 2,3-dioxygenase activity was observed (r = .451, p < .0001). 1H-indol-2-amine 100-111 neurofilament light chain Homo sapiens 40-43 31601232-6 2019 Positive correlations were also observed between NFL and kynurenine (r = .364, p < .0005), kynurenic acid (r = .384, p < .0001), 3-hydroxykynurenine (r = .246, p = .014), anthranilic acid (r = .311, p = .002), and quinolinic acid (r = .296, p = .003). Kynurenine 57-67 neurofilament light chain Homo sapiens 49-52 31601232-6 2019 Positive correlations were also observed between NFL and kynurenine (r = .364, p < .0005), kynurenic acid (r = .384, p < .0001), 3-hydroxykynurenine (r = .246, p = .014), anthranilic acid (r = .311, p = .002), and quinolinic acid (r = .296, p = .003). anthranilic acid 171-187 neurofilament light chain Homo sapiens 49-52 31601232-6 2019 Positive correlations were also observed between NFL and kynurenine (r = .364, p < .0005), kynurenic acid (r = .384, p < .0001), 3-hydroxykynurenine (r = .246, p = .014), anthranilic acid (r = .311, p = .002), and quinolinic acid (r = .296, p = .003). Quinolinic Acid 214-229 neurofilament light chain Homo sapiens 49-52 31673598-4 2019 Methods: Voxelwise regression models tested the cross-sectional association between [18F]fluorodeoxyglucose ([18F]FDG) and both plasma and cerebrospinal fluid NfL in cognitively impaired and unimpaired subjects. Fluorodeoxyglucose F18 84-107 neurofilament light chain Homo sapiens 159-162 31673598-4 2019 Methods: Voxelwise regression models tested the cross-sectional association between [18F]fluorodeoxyglucose ([18F]FDG) and both plasma and cerebrospinal fluid NfL in cognitively impaired and unimpaired subjects. Fluorodeoxyglucose F18 109-117 neurofilament light chain Homo sapiens 159-162 31673598-5 2019 Linear mixed models were also used to test the longitudinal association between NfL and [18F]FDG in amyloid positive (Abeta+) and negative (Abeta-) subjects. Fluorodeoxyglucose F18 88-96 neurofilament light chain Homo sapiens 80-83 31673598-6 2019 Results: Higher concentrations of plasma and cerebrospinal fluid NfL were associated with reduced [18F]FDG uptake in correspondent brain regions. Fluorodeoxyglucose F18 98-106 neurofilament light chain Homo sapiens 65-68 31673598-8 2019 Longitudinal changes in the association [18F]FDG-NfL were confined to cognitively impaired Abeta+ individuals. Fluorodeoxyglucose F18 40-48 neurofilament light chain Homo sapiens 49-52 31608004-7 2019 In RRMS and SPMS patients, increased NFL levels were associated with clinical relapse, and gadolinium-enhanced lesions in MRI (p < 0.001), while high CHI3L1 levels were characteristic of progressive disease (p = 0.01). Gadolinium 91-101 neurofilament light chain Homo sapiens 37-40 29737904-7 2019 RSSIs which cavitated had lower lesional ADC values and were associated with higher baseline NfL levels compared to those without cavitation, but did not differ regarding lesion size. rssis 0-5 neurofilament light chain Homo sapiens 93-96 31516913-8 2019 Baseline NfL levels were associated with worse pretreatment disease measures (Expanded Disability Status Scale [EDSS], relapses, MRI lesions, and MR spectroscopy (MRS) N-acetylaspartate/creatine). N-acetylaspartate 168-185 neurofilament light chain Homo sapiens 9-12 31145586-9 2019 We demonstrated that plasma Abeta40, Abeta42, t-tau, and NFL may be useful to identify aMCI and correlate with cognitive decline and brain atrophy. amci 87-91 neurofilament light chain Homo sapiens 57-60 31145586-10 2019 Among these plasma indicators, Abeta42 and NFL are more valuable as key members of a peripheral biomarker panel to detect aMCI. amci 122-126 neurofilament light chain Homo sapiens 43-46 31516913-8 2019 Baseline NfL levels were associated with worse pretreatment disease measures (Expanded Disability Status Scale [EDSS], relapses, MRI lesions, and MR spectroscopy (MRS) N-acetylaspartate/creatine). Creatine 186-194 neurofilament light chain Homo sapiens 9-12 30737333-3 2019 RESULTS: At baseline, NfL levels (pg/mL) were higher in patients than in healthy controls (30.5 and 27.0 vs 16.9, p = 0.0001) and correlated with T2 lesion load and number of gadolinium-enhancing T1 lesions (p < 0.0001, both). Gadolinium 175-185 neurofilament light chain Homo sapiens 22-25 30771578-9 2019 The NFL levels of CSF in the CIS, MS and NMOSD groups were correlated with the expanded disability status scale score and enhancement in gadolinium-magnetic resonance imaging (all P < 0.05). Gadolinium 137-147 neurofilament light chain Homo sapiens 4-7 29337583-3 2018 First, we provide evidence for SDA and its cost to decision makers by tabulating how often NFL teams send games into overtime by kicking an extra point rather than going for the 2-point conversion (Study 1) and how often NBA teams attempt potentially game-tying 2-point shots rather than potentially game-winning 3-pointers (Study 2). sda 31-34 neurofilament light chain Homo sapiens 91-94 30635483-5 2019 Serum NfL (median 22.0, interquartile range 11.6-40.4 pg/mL) was noticeably increased in patients with a recent relapse, with a high number of T2 and gadolinium-enhancing lesions at baseline MRI. Gadolinium 150-160 neurofilament light chain Homo sapiens 6-9 31252287-8 2019 Using the cut-off values derived from the ROCs to define N positivity, there was weak concordance between NfL and all three MRI-derived metrics of N in the subsample of 285 individuals (Cohen"s Kappas <=0.429). Nitrogen 57-58 neurofilament light chain Homo sapiens 106-109 30317548-3 2019 The aim of this study was to establish whether high-dose vitamin D supplementation reduces serum levels of NFL. Vitamin D 57-66 neurofilament light chain Homo sapiens 107-110 30317548-8 2019 In the subgroup of patients not receiving disease-modifying therapy, NFL decreased by 30.9% to week 48% and 32.6% to week 96 from baseline in the vitamin D group as compared to the placebo group (P = 0.06 for both time points). Vitamin D 146-155 neurofilament light chain Homo sapiens 69-72 28627962-8 2018 In patients starting fingolimod ( n = 243), mean NFL pg/mL ( SD) in plasma was reduced between baseline (20.4 (10.7)) and at 12 months (13.5 (7.3), p < 3 x 10-6), and levels remained stable at 24 months (13.2 (6.2)). Fingolimod Hydrochloride 21-31 neurofilament light chain Homo sapiens 49-52 29860198-5 2018 METHODS: We report on two pwPMS, who were treated with subcutaneous cladribine undergoing CSF NfL testing, alongside MRI and clinical follow-up, before and after treatment. Cladribine 68-78 neurofilament light chain Homo sapiens 94-97 29876485-2 2018 Following treatment of the HDAC inhibitors, such as MS-275, NaB, TSA, or VPA, the phenotypes of NI-hADSCs exhibit neuron-like features and the neurofilament-L (NFL)-positive cells were increased. entinostat 52-58 neurofilament light chain Homo sapiens 143-158 29142020-0 2018 Time out: NFL conflicts of interest with public health efforts to prevent TBI. Thioacetazone 74-77 neurofilament light chain Homo sapiens 10-13 29876485-2 2018 Following treatment of the HDAC inhibitors, such as MS-275, NaB, TSA, or VPA, the phenotypes of NI-hADSCs exhibit neuron-like features and the neurofilament-L (NFL)-positive cells were increased. entinostat 52-58 neurofilament light chain Homo sapiens 160-163 29876485-2 2018 Following treatment of the HDAC inhibitors, such as MS-275, NaB, TSA, or VPA, the phenotypes of NI-hADSCs exhibit neuron-like features and the neurofilament-L (NFL)-positive cells were increased. nab 60-63 neurofilament light chain Homo sapiens 143-158 29876485-2 2018 Following treatment of the HDAC inhibitors, such as MS-275, NaB, TSA, or VPA, the phenotypes of NI-hADSCs exhibit neuron-like features and the neurofilament-L (NFL)-positive cells were increased. nab 60-63 neurofilament light chain Homo sapiens 160-163 29876485-2 2018 Following treatment of the HDAC inhibitors, such as MS-275, NaB, TSA, or VPA, the phenotypes of NI-hADSCs exhibit neuron-like features and the neurofilament-L (NFL)-positive cells were increased. trichostatin A 65-68 neurofilament light chain Homo sapiens 143-158 29876485-2 2018 Following treatment of the HDAC inhibitors, such as MS-275, NaB, TSA, or VPA, the phenotypes of NI-hADSCs exhibit neuron-like features and the neurofilament-L (NFL)-positive cells were increased. trichostatin A 65-68 neurofilament light chain Homo sapiens 160-163 29876485-2 2018 Following treatment of the HDAC inhibitors, such as MS-275, NaB, TSA, or VPA, the phenotypes of NI-hADSCs exhibit neuron-like features and the neurofilament-L (NFL)-positive cells were increased. Valproic Acid 73-76 neurofilament light chain Homo sapiens 143-158 29876485-2 2018 Following treatment of the HDAC inhibitors, such as MS-275, NaB, TSA, or VPA, the phenotypes of NI-hADSCs exhibit neuron-like features and the neurofilament-L (NFL)-positive cells were increased. Valproic Acid 73-76 neurofilament light chain Homo sapiens 160-163 29079686-8 2017 Treatment with DMT reduced median serum NFL levels from 18.6 (interquartile range [IQR] 12.6-32.7) ng/L to 15.7 (IQR 9.6-22.7) ng/L (p < 0.001). dmt 15-18 neurofilament light chain Homo sapiens 40-43 28428015-5 2017 Our results showed significantly increased plasma NFL levels in both AD (50.9pg/ml) and aMCI (43.0pg/ml) groups compared to CN (34.7pg/ml) group (both p<0.001), but with substantial overlap between the groups. amci 88-92 neurofilament light chain Homo sapiens 50-53 28592540-2 2017 Previously, we coupled well-ordered cleavage-independent NFL trimers via their C-terminal polyhistidine tails to nickel lipids integrated into the lipid bilayer. polyhistidine 90-103 neurofilament light chain Homo sapiens 57-60 28592540-2 2017 Previously, we coupled well-ordered cleavage-independent NFL trimers via their C-terminal polyhistidine tails to nickel lipids integrated into the lipid bilayer. Nickel 113-119 neurofilament light chain Homo sapiens 57-60 28592540-5 2017 Both cobalt and cysteine coupling resulted in a high-density array of NFL trimers that was stable in both 20% mouse serum and 100 mM EDTA, whereas the nickel-conjugated trimers were not stable under these conditions. Cobalt 5-11 neurofilament light chain Homo sapiens 70-73 28592540-5 2017 Both cobalt and cysteine coupling resulted in a high-density array of NFL trimers that was stable in both 20% mouse serum and 100 mM EDTA, whereas the nickel-conjugated trimers were not stable under these conditions. Cysteine 16-24 neurofilament light chain Homo sapiens 70-73 28592540-5 2017 Both cobalt and cysteine coupling resulted in a high-density array of NFL trimers that was stable in both 20% mouse serum and 100 mM EDTA, whereas the nickel-conjugated trimers were not stable under these conditions. Edetic Acid 133-137 neurofilament light chain Homo sapiens 70-73 29209636-8 2018 NF-L levels were associated with the presence of T1 gadolinium-enhanced lesions up to 2 months before (p < 0.001) and 1 month after (p = 0.009) the time of biomarker measurement. Gadolinium 52-62 neurofilament light chain Homo sapiens 0-4 29046363-4 2017 RESULTS: Patients with an RSSI had higher NfL baseline levels compared to controls (73.45 vs 34.59 pg/mL, p < 0.0001), and they were increasingly higher with the time from stroke symptom onset to blood sampling (median 4 days, range 1-11 days, rs = 0.51, p < 0.0001). rssi 26-30 neurofilament light chain Homo sapiens 42-45 29046363-6 2017 NfL levels were associated with RSSI size and baseline WMH severity and were especially high in patients with new, clinically silent cerebral small vessel disease (CSVD)-related lesions at follow-up. rssi 32-36 neurofilament light chain Homo sapiens 0-3 29046363-7 2017 CONCLUSIONS: Serum NfL is increased in patients with an RSSI and the occurrence of new CSVD-related MRI lesions, even when clinically silent. rssi 56-60 neurofilament light chain Homo sapiens 19-22 28692534-5 2017 NDE were enriched for the neuronal markers neurofilament light (NF-L) and synaptophysin (SYP). NDE 0-3 neurofilament light chain Homo sapiens 64-68 28692534-7 2017 NDE from neuropsychologically impaired study participants had significantly higher levels of high-mobility group box 1 (HMGB1), NF-L, and amyloid beta proteins compared with neuropsychologically normal individuals. NDE 0-3 neurofilament light chain Homo sapiens 128-132 28148632-9 2017 Higher and increasing NfL predicted higher number of gadolinium-enhancing lesions (p < 0.001 for both). Gadolinium 53-63 neurofilament light chain Homo sapiens 22-25 27003946-5 2017 RESULTS: The levels of NFL, CXCL13, and CHI3L1 decreased ( p < 0.05) after fingolimod treatment. Fingolimod Hydrochloride 78-88 neurofilament light chain Homo sapiens 23-26 27003946-8 2017 CONCLUSION: We found reduced inflammatory activity (CXCL13, CHI3L1, and CHIT1) and reduced axonal damage (NFL) in patients switching from first-line DMTs to fingolimod. Fingolimod Hydrochloride 157-167 neurofilament light chain Homo sapiens 106-109 27503460-0 2016 Novel antibodies to phosphorylated alpha-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes. Serine 70-76 neurofilament light chain Homo sapiens 66-69 27521440-11 2016 In the replication phase, more NfL-positive patients, according to the cutoff, evolved to MS. Every 100-ng/L increase in NfL predicted CDMS (hazard ratio [HR] = 1.009, 95% CI 1.005-1.014) and McDonald MS (HR = 1.009, 95% CI 1.005-1.013), remaining significant for CDMS in the multivariate analysis (adjusted HR = 1.005, 95% CI 1.000-1.011). cdms 135-139 neurofilament light chain Homo sapiens 31-34 27521440-11 2016 In the replication phase, more NfL-positive patients, according to the cutoff, evolved to MS. Every 100-ng/L increase in NfL predicted CDMS (hazard ratio [HR] = 1.009, 95% CI 1.005-1.014) and McDonald MS (HR = 1.009, 95% CI 1.005-1.013), remaining significant for CDMS in the multivariate analysis (adjusted HR = 1.005, 95% CI 1.000-1.011). cdms 135-139 neurofilament light chain Homo sapiens 121-124 27521440-11 2016 In the replication phase, more NfL-positive patients, according to the cutoff, evolved to MS. Every 100-ng/L increase in NfL predicted CDMS (hazard ratio [HR] = 1.009, 95% CI 1.005-1.014) and McDonald MS (HR = 1.009, 95% CI 1.005-1.013), remaining significant for CDMS in the multivariate analysis (adjusted HR = 1.005, 95% CI 1.000-1.011). cdms 264-268 neurofilament light chain Homo sapiens 31-34 27521440-11 2016 In the replication phase, more NfL-positive patients, according to the cutoff, evolved to MS. Every 100-ng/L increase in NfL predicted CDMS (hazard ratio [HR] = 1.009, 95% CI 1.005-1.014) and McDonald MS (HR = 1.009, 95% CI 1.005-1.013), remaining significant for CDMS in the multivariate analysis (adjusted HR = 1.005, 95% CI 1.000-1.011). cdms 264-268 neurofilament light chain Homo sapiens 121-124 27503460-9 2016 Antibody 4F8, generated to the pSer473 NFL epitope, was relatively specific for phosphorylated NFL, however it could uniquely cross-react with pSer129 alphaS when highly phosphorylated, further showing the structural similarity between these phospho-epitopes. pser473 31-38 neurofilament light chain Homo sapiens 39-42 27503460-9 2016 Antibody 4F8, generated to the pSer473 NFL epitope, was relatively specific for phosphorylated NFL, however it could uniquely cross-react with pSer129 alphaS when highly phosphorylated, further showing the structural similarity between these phospho-epitopes. pser473 31-38 neurofilament light chain Homo sapiens 95-98 26765633-4 2016 This study examined the effect of differing doses of DHA on serum NFL over the course of a season of American football. Docosahexaenoic Acids 53-56 neurofilament light chain Homo sapiens 66-69 27295036-9 2016 CONCLUSIONS: Mild HAND was associated with increased intrathecal immune activation, and the correlation between neopterin and NFL found in NCI subjects indicates an association between neurocognitive impairment, CNS inflammation and neuronal damage. Neopterin 112-121 neurofilament light chain Homo sapiens 126-129 26765633-10 2016 Irrespective of dose, supplemental DHA likely attenuated serum NFL coincident with increases in serum NFL by likely small and moderate magnitude (effect size = 0.4-0.7). Docosahexaenoic Acids 35-38 neurofilament light chain Homo sapiens 63-66 26765633-10 2016 Irrespective of dose, supplemental DHA likely attenuated serum NFL coincident with increases in serum NFL by likely small and moderate magnitude (effect size = 0.4-0.7). Docosahexaenoic Acids 35-38 neurofilament light chain Homo sapiens 102-105 26283696-8 2016 RESULTS: CSF NF-L levels at onset predicted inter-ocular differences in follow-up LCVA (beta=13.8, p=0.0008), RNFL (beta=5.6, p=0.0004) and GC-IPL (beta=4.0, p=0.0008). lcva 82-86 neurofilament light chain Homo sapiens 13-17 27322482-0 2016 Corrigendum to: "Plasma concentration of the neurofilament light protein (NFL) is a biomarker of CNS injury in HIV infection: A cross-sectional study" [EBioMedicine 3 (216) 135-140]. ebiomedicine 152-164 neurofilament light chain Homo sapiens 45-72 27322482-0 2016 Corrigendum to: "Plasma concentration of the neurofilament light protein (NFL) is a biomarker of CNS injury in HIV infection: A cross-sectional study" [EBioMedicine 3 (216) 135-140]. ebiomedicine 152-164 neurofilament light chain Homo sapiens 74-77 26283696-8 2016 RESULTS: CSF NF-L levels at onset predicted inter-ocular differences in follow-up LCVA (beta=13.8, p=0.0008), RNFL (beta=5.6, p=0.0004) and GC-IPL (beta=4.0, p=0.0008). gc-ipl 140-146 neurofilament light chain Homo sapiens 13-17 26801564-6 2016 In addition, bisulfite sequence PCR assay demonstrated that NEFL downregulation was associated with promoter methylation, and NEFL expression was restored after treatment with 5-Aza-dC. hydrogen sulfite 13-22 neurofilament light chain Homo sapiens 60-64 26801564-6 2016 In addition, bisulfite sequence PCR assay demonstrated that NEFL downregulation was associated with promoter methylation, and NEFL expression was restored after treatment with 5-Aza-dC. Decitabine 176-184 neurofilament light chain Homo sapiens 60-64 26801564-6 2016 In addition, bisulfite sequence PCR assay demonstrated that NEFL downregulation was associated with promoter methylation, and NEFL expression was restored after treatment with 5-Aza-dC. Decitabine 176-184 neurofilament light chain Homo sapiens 126-130 26109717-11 2015 The study of the nodal/paranodal architecture demonstrated that sodium channels and Caspr were correctly localized in patients with CMT2E. Sodium 64-70 neurofilament light chain Homo sapiens 132-137 25716934-5 2016 When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR = 2.36; 95% CI 1.21 to 4.59; p = 0.011), gadolinium-enhancing lesions (OR = 2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR = 2.54; 95% CI 1.21 to 5.31; p = 0.013) at CIS diagnosis. Gadolinium 179-189 neurofilament light chain Homo sapiens 41-44 26799209-4 2016 We showed 1326 differentially expressed Caco-2 transcripts after treatment with iodine-biofortified (BFL) and non-fortified (NFL) lettuce extracts. Iodine 80-86 neurofilament light chain Homo sapiens 125-128 26799209-6 2016 Iodine, which was expected to act as a free ion (KI-NFL) or at least in part to be incorporated into lettuce macromolecules (BFL), differently regulated pathways of numerous transcription factors leading to different cellular effects. Iodine 0-6 neurofilament light chain Homo sapiens 52-55 26014362-7 2015 p-Tie-2 expression dramatically decreased after treatment with a Tie-2 kinase inhibitor (S157701), which consequently decreased the level of NF68. s157701 89-96 neurofilament light chain Homo sapiens 141-145 24078718-7 2014 There was no difference in anti-NF plasma antibodies between ALS individuals treated with riluzole and untreated patients; although riluzole-treated ALS cases with an earlier age of onset and with a shorter diagnostic delay displayed higher anti-NFL antibody levels compared to untreated ALS patients with similar features. Riluzole 132-140 neurofilament light chain Homo sapiens 246-249 25778866-7 2015 Key genes relevant to cell neurogenesis, e.g., neurofilament light chain (NFL), were also upregulated on graphene. Graphite 105-113 neurofilament light chain Homo sapiens 74-77 25732842-3 2015 RESULTS: High levels of NFL were associated with early conversion from CIS to CDMS (hazard ratio (HR) with 95% confidence interval (CI): 2.69 (1.75 - 4.15); p < 0.0001). cdms 78-82 neurofilament light chain Homo sapiens 24-27 25732842-6 2015 CONCLUSIONS: CSF levels of NFL in CIS patients are an independent prognostic marker for conversion to CDMS. cdms 102-106 neurofilament light chain Homo sapiens 27-30 24750431-5 2015 CONCLUSIONS: This study shows that in sporadic ALS NFL, a marker of neurodegeneration, is correlated with TTG, a clinical intermediate parameter of survivorship. Hydrotopotecan 106-109 neurofilament light chain Homo sapiens 51-54 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Nitrogen Dioxide 97-100 neurofilament light chain Homo sapiens 238-241 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Polycyclic Aromatic Hydrocarbons 118-150 neurofilament light chain Homo sapiens 238-241 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Polycyclic Aromatic Hydrocarbons 152-156 neurofilament light chain Homo sapiens 238-241 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. nitro 208-213 neurofilament light chain Homo sapiens 238-241 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Polycyclic Aromatic Hydrocarbons 152-155 neurofilament light chain Homo sapiens 238-241 24694925-8 2014 We also identified positive associations between NF-L and treatment with atypical antipsychotics, MBP and lamotrigine, and H-FABP and lithium. Lamotrigine 106-117 neurofilament light chain Homo sapiens 49-53 25835709-3 2015 We here determined levels of neurofilament-light (NFL), a marker for ongoing nerve injury, C3 and activity of the two main ACh hydrolyzing enzymes, acetylcholinesterase (AChE) and BuChE, in cerebrospinal fluid (CSF) from patients with MS (n = 48) and non-inflammatory controls (n = 18). Acetylcholine 123-126 neurofilament light chain Homo sapiens 50-53 24935984-8 2015 Minocycline treatment showed decreased NfL levels in the subgroup of cSCI patients. Minocycline 0-11 neurofilament light chain Homo sapiens 39-42 25605243-2 2015 In this study, we employed two-dimensional fluorescence differential gel electrophoresis (2-D DIGE) and MALDI-TOF/TOF-MS/MS to identify 27 differentially expressed proteins, including the significantly upregulated neurofilament light polypeptide (NEFL), in glioblastoma cells in which miR-381 expression was inhibited. dige 94-98 neurofilament light chain Homo sapiens 214-245 25605243-5 2015 Either suppressing miR-381 or enforcing NEFL expression dramatically sensitized glioblastoma cells to temozolomide (TMZ), a promising chemotherapeutic agent for treating GBMs. Temozolomide 102-114 neurofilament light chain Homo sapiens 40-44 25605243-5 2015 Either suppressing miR-381 or enforcing NEFL expression dramatically sensitized glioblastoma cells to temozolomide (TMZ), a promising chemotherapeutic agent for treating GBMs. Temozolomide 116-119 neurofilament light chain Homo sapiens 40-44 25605243-7 2015 Our results further demonstrated that miR-381 overexpression reversed the viability of U251 cells exhibiting NEFL-mediated TMZ sensitivity. Temozolomide 123-126 neurofilament light chain Homo sapiens 109-113 25329713-1 2014 Atmospheric 2-nitrofluoranthene (2-NFL) and 2-nitropyrene (2-NPY) were two important nitro-polycyclic aromatic hydrocarbons (NPAHs). 2-nitrofluoranthene 12-31 neurofilament light chain Homo sapiens 35-38 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. nitrogen pentoxide 88-92 neurofilament light chain Homo sapiens 238-241 24571714-5 2014 RESULTS: Patients in clinical relapse and patients with nonsymptomatic gadolinium enhancing lesions had high levels of MBP and NFL, indicating ongoing damage to oligodendrocytes and axons. Gadolinium 71-81 neurofilament light chain Homo sapiens 127-130 22835604-0 2013 Rho guanine nucleotide exchange factor is an NFL mRNA destabilizing factor that forms cytoplasmic inclusions in amyotrophic lateral sclerosis. Guanine Nucleotides 4-22 neurofilament light chain Homo sapiens 45-48 24523921-9 2014 Neopterin correlated with NFL levels in untreated groups while the albumin ratio correlated with NFL in both untreated and treated groups. Neopterin 0-9 neurofilament light chain Homo sapiens 26-29 24523921-12 2014 NFL correlates with neopterin and albumin ratio, suggesting an association between axonal injury, neuroinflammation and blood-brain barrier permeability. Neopterin 20-29 neurofilament light chain Homo sapiens 0-3 24242746-8 2014 CSF NfL, but not other CSF measures, correlated with CDRsb and neuropsychological measures in FTD, but not in other diagnostic groups. cdrsb 53-58 neurofilament light chain Homo sapiens 4-7 23743148-6 2013 Pretreatment cells with 3-methyladenine (3-MA), an autophagy inhibitor, not only inhibited the TOCP-induced autophagy, but also reversed the inhibition of neurite outgrowth and the degradation of NF-H, NF-L, and beta-tubulin by TOCP. 3-methyladenine 24-39 neurofilament light chain Homo sapiens 202-206 23743148-6 2013 Pretreatment cells with 3-methyladenine (3-MA), an autophagy inhibitor, not only inhibited the TOCP-induced autophagy, but also reversed the inhibition of neurite outgrowth and the degradation of NF-H, NF-L, and beta-tubulin by TOCP. 3-methyladenine 41-45 neurofilament light chain Homo sapiens 202-206 23228886-0 2013 Oxidative modification of neurofilament-L and neuronal cell death induced by the catechol neurotoxin, tetrahydropapaveroline. catechol 81-89 neurofilament light chain Homo sapiens 26-41 23228886-0 2013 Oxidative modification of neurofilament-L and neuronal cell death induced by the catechol neurotoxin, tetrahydropapaveroline. Tetrahydropapaveroline 102-124 neurofilament light chain Homo sapiens 26-41 23228886-3 2013 When disassembled NF-L was incubated with THP, protein aggregation was increased in a time- and THP dose-dependent manner. Tetrahydropapaveroline 42-45 neurofilament light chain Homo sapiens 18-22 23228886-3 2013 When disassembled NF-L was incubated with THP, protein aggregation was increased in a time- and THP dose-dependent manner. Tetrahydropapaveroline 96-99 neurofilament light chain Homo sapiens 18-22 23228886-4 2013 The formation of carbonyl compounds and dityrosine were observed in the THP-mediated NF-L aggregates. dityrosine 40-50 neurofilament light chain Homo sapiens 85-89 23228886-4 2013 The formation of carbonyl compounds and dityrosine were observed in the THP-mediated NF-L aggregates. Tetrahydropapaveroline 72-75 neurofilament light chain Homo sapiens 85-89 23228886-5 2013 Radical scavengers reduced THP-mediated NF-L modification. Tetrahydropapaveroline 27-30 neurofilament light chain Homo sapiens 40-44 23228886-6 2013 These results suggest that the modification of NF-L by THP may be due to oxidative damage resulting from the generation of reactive oxygen species (ROS). Tetrahydropapaveroline 55-58 neurofilament light chain Homo sapiens 47-51 23228886-6 2013 These results suggest that the modification of NF-L by THP may be due to oxidative damage resulting from the generation of reactive oxygen species (ROS). Reactive Oxygen Species 123-146 neurofilament light chain Homo sapiens 47-51 23228886-6 2013 These results suggest that the modification of NF-L by THP may be due to oxidative damage resulting from the generation of reactive oxygen species (ROS). Reactive Oxygen Species 148-151 neurofilament light chain Homo sapiens 47-51 23228886-7 2013 When THP exposed NF-L was subjected to amino acid analysis, glutamate, proline and lysine residues were found to be particularly sensitive. Tetrahydropapaveroline 5-8 neurofilament light chain Homo sapiens 17-21 23228886-7 2013 When THP exposed NF-L was subjected to amino acid analysis, glutamate, proline and lysine residues were found to be particularly sensitive. Glutamic Acid 60-69 neurofilament light chain Homo sapiens 17-21 23228886-7 2013 When THP exposed NF-L was subjected to amino acid analysis, glutamate, proline and lysine residues were found to be particularly sensitive. Proline 71-78 neurofilament light chain Homo sapiens 17-21 23228886-7 2013 When THP exposed NF-L was subjected to amino acid analysis, glutamate, proline and lysine residues were found to be particularly sensitive. Lysine 83-89 neurofilament light chain Homo sapiens 17-21 23228886-8 2013 We also investigated the effects of copper ions on THP-mediated NF-L modification. Tetrahydropapaveroline 51-54 neurofilament light chain Homo sapiens 64-68 23228886-9 2013 At a low concentration of THP, copper ions enhanced the modification of NF-L. Tetrahydropapaveroline 26-29 neurofilament light chain Homo sapiens 72-76 23228886-9 2013 At a low concentration of THP, copper ions enhanced the modification of NF-L. Copper 31-37 neurofilament light chain Homo sapiens 72-76 23228886-12 2013 Furthermore, treatment of cells with THP increased NF-L aggregate formation, suggesting the involvement of NF-L modification in THP-induced cell damage. Tetrahydropapaveroline 37-40 neurofilament light chain Homo sapiens 51-55 23228886-12 2013 Furthermore, treatment of cells with THP increased NF-L aggregate formation, suggesting the involvement of NF-L modification in THP-induced cell damage. Tetrahydropapaveroline 37-40 neurofilament light chain Homo sapiens 107-111 23228886-12 2013 Furthermore, treatment of cells with THP increased NF-L aggregate formation, suggesting the involvement of NF-L modification in THP-induced cell damage. Tetrahydropapaveroline 128-131 neurofilament light chain Homo sapiens 107-111 23230147-5 2013 Investigation of mutations of phospho-serine sites at the head domain of NF-L revealed that several phosphorylation sites, particularly Ser43 and Ser55, were important for 14-3-3 binding. Serine 38-44 neurofilament light chain Homo sapiens 73-77 22115181-5 2012 The results showed that the preinduced cells were immunoreactive for nestin and NF-68; among the mentioned protocols, the immunoreactivity yielded by following the DMSO-RA protocol was significantly higher than the others. dmso-ra 164-171 neurofilament light chain Homo sapiens 80-85 19286384-0 2009 The neurofilament light chain gene (NEFL) mutation Pro22Ser can be associated with mixed axonal and demyelinating neuropathy. pro22ser 51-59 neurofilament light chain Homo sapiens 36-40 23272063-9 2012 We also pointed out 9 proteins that changed in both the amygdala and the cortex, and from these, GFAP, INA, NEFL, NEFM and TUBA1 are interacting cytoskeletal proteins that have a functional connection to glutamate, GABA, and serotonin receptors. Glutamic Acid 204-213 neurofilament light chain Homo sapiens 108-112 23272063-9 2012 We also pointed out 9 proteins that changed in both the amygdala and the cortex, and from these, GFAP, INA, NEFL, NEFM and TUBA1 are interacting cytoskeletal proteins that have a functional connection to glutamate, GABA, and serotonin receptors. gamma-Aminobutyric Acid 215-219 neurofilament light chain Homo sapiens 108-112 22246235-3 2012 In this study, we identified neurofilament light polypeptide (NEFL) as a novel hypermethylated gene associated with resistance to cisplatin-based chemotherapy in HNC. Cisplatin 130-139 neurofilament light chain Homo sapiens 29-60 22246235-3 2012 In this study, we identified neurofilament light polypeptide (NEFL) as a novel hypermethylated gene associated with resistance to cisplatin-based chemotherapy in HNC. Cisplatin 130-139 neurofilament light chain Homo sapiens 62-66 22246235-4 2012 Analysis of 14 HNC cell lines revealed that downregulation of NEFL expression significantly correlated with increased resistance to cisplatin. Cisplatin 132-141 neurofilament light chain Homo sapiens 62-66 22246235-6 2012 Furthermore, in patient samples with HNC (n = 51) analyzed by quantitative MSP, NEFL promoter hypermethylation was associated with resistance to cisplatin-based chemotherapy [relative risk (RR), 3.045; 95% confidence interval (CI), 1.459-6.355; P = 0.007] and predicted diminished overall and disease-free survival for patients treated with cisplatin-based chemotherapy. Cisplatin 145-154 neurofilament light chain Homo sapiens 80-84 22246235-6 2012 Furthermore, in patient samples with HNC (n = 51) analyzed by quantitative MSP, NEFL promoter hypermethylation was associated with resistance to cisplatin-based chemotherapy [relative risk (RR), 3.045; 95% confidence interval (CI), 1.459-6.355; P = 0.007] and predicted diminished overall and disease-free survival for patients treated with cisplatin-based chemotherapy. Cisplatin 341-350 neurofilament light chain Homo sapiens 80-84 22246235-7 2012 Knockdown of NEFL by siRNA in the highly cisplatin-sensitive cell line PCI13 increased (P < 0.01) resistance to cisplatin. Cisplatin 41-50 neurofilament light chain Homo sapiens 13-17 22246235-7 2012 Knockdown of NEFL by siRNA in the highly cisplatin-sensitive cell line PCI13 increased (P < 0.01) resistance to cisplatin. Cisplatin 115-124 neurofilament light chain Homo sapiens 13-17 22246235-8 2012 In cisplatin-resistant O11 and SCC25cp cells, restored expression of NEFL significantly increased sensitivity to the drug. Cisplatin 3-12 neurofilament light chain Homo sapiens 69-73 22246235-9 2012 Furthermore, NEFL physically associated with tuberous sclerosis complex 1 (TSC1), a known inhibitor of the mTOR pathway, and NEFL downregulation led to functional activation of mTOR pathway and consequentially conferred cisplatin resistance. Cisplatin 220-229 neurofilament light chain Homo sapiens 13-17 22246235-9 2012 Furthermore, NEFL physically associated with tuberous sclerosis complex 1 (TSC1), a known inhibitor of the mTOR pathway, and NEFL downregulation led to functional activation of mTOR pathway and consequentially conferred cisplatin resistance. Cisplatin 220-229 neurofilament light chain Homo sapiens 125-129 22360890-0 2012 Salsolinol, a tetrahydroisoquinoline-derived neurotoxin, induces oxidative modification of neurofilament-L protection by histidyl dipeptides. salsolinol 0-10 neurofilament light chain Homo sapiens 91-106 22360890-0 2012 Salsolinol, a tetrahydroisoquinoline-derived neurotoxin, induces oxidative modification of neurofilament-L protection by histidyl dipeptides. 1,2,3,4-tetrahydroisoquinoline 14-36 neurofilament light chain Homo sapiens 91-106 22360890-0 2012 Salsolinol, a tetrahydroisoquinoline-derived neurotoxin, induces oxidative modification of neurofilament-L protection by histidyl dipeptides. histidyl dipeptides 121-140 neurofilament light chain Homo sapiens 91-106 22360890-3 2012 In this study, oxidative modification of neurofilament-L (NF-L) by salsolinol and the inhibitory effects of histidyl dipeptides on NF-L modification were investigated. salsolinol 67-77 neurofilament light chain Homo sapiens 41-56 22360890-3 2012 In this study, oxidative modification of neurofilament-L (NF-L) by salsolinol and the inhibitory effects of histidyl dipeptides on NF-L modification were investigated. salsolinol 67-77 neurofilament light chain Homo sapiens 58-62 22360890-3 2012 In this study, oxidative modification of neurofilament-L (NF-L) by salsolinol and the inhibitory effects of histidyl dipeptides on NF-L modification were investigated. Dipeptides 117-127 neurofilament light chain Homo sapiens 131-135 22360890-4 2012 When NF-L was incubated with 0.5 mM salsolinol, the aggregation of protein was increased in a time-dependent manner. salsolinol 36-46 neurofilament light chain Homo sapiens 5-9 22360890-6 2012 NF-L exposure to salsolinol produced losses of glutamate, lysine and proline residues. salsolinol 17-27 neurofilament light chain Homo sapiens 0-4 22360890-6 2012 NF-L exposure to salsolinol produced losses of glutamate, lysine and proline residues. Glutamic Acid 47-56 neurofilament light chain Homo sapiens 0-4 22360890-6 2012 NF-L exposure to salsolinol produced losses of glutamate, lysine and proline residues. Lysine 58-64 neurofilament light chain Homo sapiens 0-4 22360890-6 2012 NF-L exposure to salsolinol produced losses of glutamate, lysine and proline residues. Proline 69-76 neurofilament light chain Homo sapiens 0-4 22360890-7 2012 These results suggest that the aggregation of NF-L by salsolinol may be due to oxidative damage resulting from free radicals. salsolinol 54-64 neurofilament light chain Homo sapiens 46-50 22360890-7 2012 These results suggest that the aggregation of NF-L by salsolinol may be due to oxidative damage resulting from free radicals. free 111-115 neurofilament light chain Homo sapiens 46-50 22360890-9 2012 Carnosine, and anserine were shown to significantly prevent salsolinol- mediated NF-L aggregation. Anserine 15-23 neurofilament light chain Homo sapiens 81-85 22360890-9 2012 Carnosine, and anserine were shown to significantly prevent salsolinol- mediated NF-L aggregation. salsolinol 60-70 neurofilament light chain Homo sapiens 81-85 22360890-11 2012 The results indicated that carnosine and related compounds may prevent salsolinol-mediated NF-L modification via free radical scavenging. salsolinol 71-81 neurofilament light chain Homo sapiens 91-95 20571038-3 2011 We hypothesised that patients with aSAH would have elevated cerebrospinal fluid (CSF) NF-L levels and sought to explore the clinical correlates of CSF NF-L dynamics. asah 35-39 neurofilament light chain Homo sapiens 86-90 20571038-7 2011 RESULTS: vCSF NF-L concentrations were elevated in all patients with aSAH. asah 69-73 neurofilament light chain Homo sapiens 14-18 22395135-12 2011 The results of neural differentiation showed the highest percentage of nestin and NF-68 positive cells at 10(-9) mM concentration of selegiline (exposed for 24 h). Selegiline 133-143 neurofilament light chain Homo sapiens 82-87 20557103-6 2010 Further, we find cross-correlations between neurofilament side-arms within the brush, even for the NF-L polymers. Polymers 104-112 neurofilament light chain Homo sapiens 99-103 20039262-7 2009 All four affected children were homozygous for a nonsense mutation at glutamate 210 (E210X) in the NEFL gene; both parents were heterozygous carriers. Glutamic Acid 70-79 neurofilament light chain Homo sapiens 99-103 19286384-2 2009 DNA sequencing of the coding sequences of the neurofilament light chain polypeptide (NEFL) gene revealed a c.64C>T heterozygous, missense mutation resulting in a Pro22Ser amino acid substitution. pro22ser 162-170 neurofilament light chain Homo sapiens 85-89 18823586-0 2008 Acrolein, the toxic endogenous aldehyde, induces neurofilament-L aggregation. Acrolein 0-8 neurofilament light chain Homo sapiens 49-64 19123978-8 2008 These results suggest that alanine at position 148 is essentially required for NF-L self-assembly leading to subsequent filament formation in neuronal cells. Alanine 27-34 neurofilament light chain Homo sapiens 79-83 18823586-0 2008 Acrolein, the toxic endogenous aldehyde, induces neurofilament-L aggregation. Aldehydes 31-39 neurofilament light chain Homo sapiens 49-64 18823586-2 2008 In the present study, we examined the pattern of neurofilament-L (NF-L) modification elicited by acrolein. Acrolein 97-105 neurofilament light chain Homo sapiens 49-64 18823586-2 2008 In the present study, we examined the pattern of neurofilament-L (NF-L) modification elicited by acrolein. Acrolein 97-105 neurofilament light chain Homo sapiens 66-70 18823586-3 2008 When NF-L was incubated with acrolein, protein aggregation occurred in a acrolein concentration-dependent manner. Acrolein 29-37 neurofilament light chain Homo sapiens 5-9 18823586-3 2008 When NF-L was incubated with acrolein, protein aggregation occurred in a acrolein concentration-dependent manner. Acrolein 73-81 neurofilament light chain Homo sapiens 5-9 18823586-4 2008 Exposure of NF-L to acrolein also led to the generation of protein carbonyl compounds. Acrolein 20-28 neurofilament light chain Homo sapiens 12-16 18823586-5 2008 Through the addition of free radical scavengers we observed a significant decrease in acrolein-mediated NF-L aggregation. Free Radicals 24-36 neurofilament light chain Homo sapiens 104-108 18823586-5 2008 Through the addition of free radical scavengers we observed a significant decrease in acrolein-mediated NF-L aggregation. Acrolein 86-94 neurofilament light chain Homo sapiens 104-108 18823586-6 2008 These results indicate that free radicals may be involved in the modification of NF-L by acrolein. Acrolein 89-97 neurofilament light chain Homo sapiens 81-85 18823586-7 2008 In addition, dityrosine crosslink formation was observed in acrolein-mediated NF-L aggregates and these aggregates displayed thioflavin T reactivity, reminiscent of amyloid. dityrosine 13-23 neurofilament light chain Homo sapiens 78-82 18823586-7 2008 In addition, dityrosine crosslink formation was observed in acrolein-mediated NF-L aggregates and these aggregates displayed thioflavin T reactivity, reminiscent of amyloid. Acrolein 60-68 neurofilament light chain Homo sapiens 78-82 18823586-7 2008 In addition, dityrosine crosslink formation was observed in acrolein-mediated NF-L aggregates and these aggregates displayed thioflavin T reactivity, reminiscent of amyloid. thioflavin T 125-137 neurofilament light chain Homo sapiens 78-82 18823586-8 2008 This study suggests that acrolein-mediated NF-L aggregation might be closely related to oxidative reactions, thus these reactions may play a critical role in neurodegenerative diseases. Acrolein 25-33 neurofilament light chain Homo sapiens 43-47 16678934-3 2007 RESULTS: CSF levels of NFL, NFHp35, and tau were significantly increased in MSA-P (all p<0.0001), whereas, MHPG levels were significantly decreased in MSA-P (p<0.0001). msa-p 76-81 neurofilament light chain Homo sapiens 23-26 17923616-7 2007 These effects on CSF NFL were seen in association with clinical improvement in ADC patients, decreases in plasma and CSF HIV-1 RNA and CSF neopterin, and increases in blood CD4 T cell counts. Neopterin 139-148 neurofilament light chain Homo sapiens 21-24 17955054-8 2008 When FLX treatment was withdrawn for 90 days in those LH-FLX animals in which reversion of despair had been observed at day 25, recurrence of despaired behavior was found accompanied by decreased SYN, PSD-95, and NFL labelings. Fluoxetine 5-8 neurofilament light chain Homo sapiens 213-216 17683840-2 2007 We investigated the efficacy of valproic acid (VPA) for reversing a depressive-like behaviour and a cytoskeletal alteration in the hippocampus, the loss of the light neurofilament subunit (NF-L). Valproic Acid 32-45 neurofilament light chain Homo sapiens 166-193 17683840-2 2007 We investigated the efficacy of valproic acid (VPA) for reversing a depressive-like behaviour and a cytoskeletal alteration in the hippocampus, the loss of the light neurofilament subunit (NF-L). Valproic Acid 47-50 neurofilament light chain Homo sapiens 166-193 17553662-7 2007 On the other hand, MMA(V) and DMA(V) cause significant changes in expression levels of NEF3 and NEFL genes, while the expression level of the NEFH gene is significantly increased in both cell lines. N-myristoyl-alaninol 30-33 neurofilament light chain Homo sapiens 96-100 17475803-2 2007 Doxycycline treatment caused the rapid disappearance of human NF-L (hNF-L) mRNA in tTA;hNF-L mice, but the hNF-L proteins remained with a half-life of 3 weeks in the brain. Doxycycline 0-11 neurofilament light chain Homo sapiens 62-66 17475803-2 2007 Doxycycline treatment caused the rapid disappearance of human NF-L (hNF-L) mRNA in tTA;hNF-L mice, but the hNF-L proteins remained with a half-life of 3 weeks in the brain. Doxycycline 0-11 neurofilament light chain Homo sapiens 68-73 17475803-2 2007 Doxycycline treatment caused the rapid disappearance of human NF-L (hNF-L) mRNA in tTA;hNF-L mice, but the hNF-L proteins remained with a half-life of 3 weeks in the brain. Doxycycline 0-11 neurofilament light chain Homo sapiens 87-92 17475803-2 2007 Doxycycline treatment caused the rapid disappearance of human NF-L (hNF-L) mRNA in tTA;hNF-L mice, but the hNF-L proteins remained with a half-life of 3 weeks in the brain. Doxycycline 0-11 neurofilament light chain Homo sapiens 87-92 17475803-3 2007 In the sciatic nerve, the disappearance of hNF-L proteins after doxycycline treatment occurred in synchrony along the sciatic nerve, suggesting a proteolysis of NF proteins along the entire axon. Doxycycline 64-75 neurofilament light chain Homo sapiens 43-48 17475803-7 2007 We estimated the hNF-L transport rate to be of approximately 10 mm/d in axons devoid of NF structures based on the use of an adenovirus encoding tet-responsive transcriptional activator to transactivate the hNF-L transgene in hypoglossal motor neurons. tetramethylenedisulfotetramine 145-148 neurofilament light chain Homo sapiens 17-22 17475803-7 2007 We estimated the hNF-L transport rate to be of approximately 10 mm/d in axons devoid of NF structures based on the use of an adenovirus encoding tet-responsive transcriptional activator to transactivate the hNF-L transgene in hypoglossal motor neurons. tetramethylenedisulfotetramine 145-148 neurofilament light chain Homo sapiens 207-212 16678934-5 2007 Multivariate logistic regression resulted in the combination of NFL and tau as independent contributors in differentiating between MSA-P and IPD. msa-p 131-136 neurofilament light chain Homo sapiens 64-67 16702973-7 2006 In addition, we studied expression of the NMDA-interacting PSD molecules NF-L, SAP102, PSD-95 and PSD-93 in ACC and DLPFC at both transcriptional and translational levels. N-Methylaspartate 42-46 neurofilament light chain Homo sapiens 73-77 17244493-0 2007 Protective effects of histidine dipeptides on the modification of neurofilament-L by the cytochrome c/hydrogen peroxide system. Histidine 22-31 neurofilament light chain Homo sapiens 66-81 17244493-0 2007 Protective effects of histidine dipeptides on the modification of neurofilament-L by the cytochrome c/hydrogen peroxide system. Dipeptides 32-42 neurofilament light chain Homo sapiens 66-81 17244493-0 2007 Protective effects of histidine dipeptides on the modification of neurofilament-L by the cytochrome c/hydrogen peroxide system. Hydrogen Peroxide 102-119 neurofilament light chain Homo sapiens 66-81 17244493-4 2007 In the present study, we investigated whether histidine dipeptides, carnosine, homocarnosine, or anserine protect NF-L against oxidative modification during reaction between cytochrome c and H(2)O(2). Histidine 46-55 neurofilament light chain Homo sapiens 114-118 17244493-4 2007 In the present study, we investigated whether histidine dipeptides, carnosine, homocarnosine, or anserine protect NF-L against oxidative modification during reaction between cytochrome c and H(2)O(2). Dipeptides 56-66 neurofilament light chain Homo sapiens 114-118 17244493-4 2007 In the present study, we investigated whether histidine dipeptides, carnosine, homocarnosine, or anserine protect NF-L against oxidative modification during reaction between cytochrome c and H(2)O(2). Anserine 97-105 neurofilament light chain Homo sapiens 114-118 17244493-5 2007 Carnosine, homocarnosine and anserine all prevented cytochrome c/H(2)O(2)-mediated NF-L aggregation. Anserine 29-37 neurofilament light chain Homo sapiens 83-87 17244493-5 2007 Carnosine, homocarnosine and anserine all prevented cytochrome c/H(2)O(2)-mediated NF-L aggregation. (2)o(2) 66-73 neurofilament light chain Homo sapiens 83-87 16473419-8 2006 After 10 h of treatment with 10 microg/ml safrole oxide, some HUVECs became neuron-like cells in morphology, and intensively displayed positive NSE and NF-L. safrole oxide 42-55 neurofilament light chain Homo sapiens 152-156 16307021-0 2006 Nfl gene inactivation in acute myeloid leukemia cells confers cytarabine resistance through MAPK and mTOR pathways. Cytarabine 62-72 neurofilament light chain Homo sapiens 0-3 15033415-8 2004 With NMDA stimulation, aggregate-bearing hNFL+/+ motor neurons demonstrated significant increases in intracellular calcium, whereas only a minimal alteration in intracellular calcium was observed in C57 Bl/6 neurons. N-Methylaspartate 5-9 neurofilament light chain Homo sapiens 41-45 15308290-5 2004 Treatment of SSCs with GDNF, PACAP, and dbcAMP increased the production of neurofilament light protein (NF-L) and a cytoskeleton protein-alpha-tubulin. Bucladesine 40-46 neurofilament light chain Homo sapiens 75-102 15308290-5 2004 Treatment of SSCs with GDNF, PACAP, and dbcAMP increased the production of neurofilament light protein (NF-L) and a cytoskeleton protein-alpha-tubulin. Bucladesine 40-46 neurofilament light chain Homo sapiens 104-108 15388232-0 2004 Oxidative modification of neurofilament-L by the Cu,Zn-superoxide dismutase and hydrogen peroxide system. Hydrogen Peroxide 80-97 neurofilament light chain Homo sapiens 26-41 15388232-3 2004 When disassembled NF-L was incubated with Cu,Zn-SOD and H2O2, the aggregation of protein was proportional to the concentration of hydrogen peroxide. Hydrogen Peroxide 56-60 neurofilament light chain Homo sapiens 18-22 15388232-3 2004 When disassembled NF-L was incubated with Cu,Zn-SOD and H2O2, the aggregation of protein was proportional to the concentration of hydrogen peroxide. Hydrogen Peroxide 130-147 neurofilament light chain Homo sapiens 18-22 15388232-4 2004 Cu,Zn-SOD/H2O2-mediated modification of NF-L was significantly inhibited by radical scavenger, spin trap agents and copper chelators. Copper 0-2 neurofilament light chain Homo sapiens 40-44 15388232-4 2004 Cu,Zn-SOD/H2O2-mediated modification of NF-L was significantly inhibited by radical scavenger, spin trap agents and copper chelators. Hydrogen Peroxide 10-14 neurofilament light chain Homo sapiens 40-44 15388232-4 2004 Cu,Zn-SOD/H2O2-mediated modification of NF-L was significantly inhibited by radical scavenger, spin trap agents and copper chelators. Copper 116-122 neurofilament light chain Homo sapiens 40-44 15388232-5 2004 Dityrosine crosslink formation was obtained in Cu,Zn-SOD/H2O2-mediated NF-L aggregates. dityrosine 0-10 neurofilament light chain Homo sapiens 71-75 15388232-5 2004 Dityrosine crosslink formation was obtained in Cu,Zn-SOD/H2O2-mediated NF-L aggregates. Copper 47-49 neurofilament light chain Homo sapiens 71-75 15388232-5 2004 Dityrosine crosslink formation was obtained in Cu,Zn-SOD/H2O2-mediated NF-L aggregates. Hydrogen Peroxide 57-61 neurofilament light chain Homo sapiens 71-75 15388232-6 2004 Antioxidant molecules, carnosine and anserine significantly inhibited the aggregation of NF-L and the formation of dityrosine. Anserine 37-45 neurofilament light chain Homo sapiens 89-93 15388232-7 2004 This study suggests that copper-mediated NF-L modification may be closely related to oxidative reactions which play a critical role in neurodegenerative diseases. Copper 25-31 neurofilament light chain Homo sapiens 41-45 15033415-8 2004 With NMDA stimulation, aggregate-bearing hNFL+/+ motor neurons demonstrated significant increases in intracellular calcium, whereas only a minimal alteration in intracellular calcium was observed in C57 Bl/6 neurons. Calcium 115-122 neurofilament light chain Homo sapiens 41-45 15033415-9 2004 Following stimulation with 100 microM NMDA, 75.5+/-5.5% of hNFL+/+ neurons became apoptotic, whereas only 16.3+/-5.3% of C57 Bl/6 were. N-Methylaspartate 38-42 neurofilament light chain Homo sapiens 59-63 14967049-7 2004 Ser(66) was previously not known to be phosphorylated in NFL of other species, while two sites (Ser(55) and Ser(472)) are consistent with the phosphorylations observed in other mammalian NFLs. Serine 0-3 neurofilament light chain Homo sapiens 57-60 15361639-0 2003 Phase II clinical trial of 5-fluorouracil, trimetrexate, and leucovorin (NFL) in patients with advanced pancreatic cancer. Fluorouracil 27-41 neurofilament light chain Homo sapiens 73-76 14969737-8 2004 In this study, we investigated dopamine-glutamate interactions by measuring the expression of transcripts encoding the subunits for the ionotropic glutamate receptors (NMDA, AMPA and kainate) and five NMDAR-associated intracellular proteins, PSD-93, PSD-95, SAP102, NF-L and yotiao in the dopaminergic neurons in the substantia nigra pars compacta (SNc) of subjects with schizophrenia and a comparison group. Dopamine 31-39 neurofilament light chain Homo sapiens 266-270 14536032-0 2003 Oxidative modification of neurofilament-L by copper-catalyzed reaction. Copper 45-51 neurofilament light chain Homo sapiens 26-41 14536032-2 2003 Since oxidative stress might play a critical role in the pathogenesis of neurodegenerative diseases, we investigated the role of copper and peroxide in the modification of NF-L. Copper 129-135 neurofilament light chain Homo sapiens 172-176 14536032-2 2003 Since oxidative stress might play a critical role in the pathogenesis of neurodegenerative diseases, we investigated the role of copper and peroxide in the modification of NF-L. Peroxides 140-148 neurofilament light chain Homo sapiens 172-176 14536032-3 2003 When disassembled NF-L was incubated with copper ion and hydrogen peroxide, then the aggregation of protein was proportional to copper and hydrogen peroxide concentrations. Copper 42-48 neurofilament light chain Homo sapiens 18-22 14536032-3 2003 When disassembled NF-L was incubated with copper ion and hydrogen peroxide, then the aggregation of protein was proportional to copper and hydrogen peroxide concentrations. Hydrogen Peroxide 57-74 neurofilament light chain Homo sapiens 18-22 14536032-3 2003 When disassembled NF-L was incubated with copper ion and hydrogen peroxide, then the aggregation of protein was proportional to copper and hydrogen peroxide concentrations. Copper 128-134 neurofilament light chain Homo sapiens 18-22 14536032-3 2003 When disassembled NF-L was incubated with copper ion and hydrogen peroxide, then the aggregation of protein was proportional to copper and hydrogen peroxide concentrations. Hydrogen Peroxide 139-156 neurofilament light chain Homo sapiens 18-22 14536032-4 2003 Dityrosine crosslink formation was obtained in copper-mediated NF-L aggregates. dityrosine 0-10 neurofilament light chain Homo sapiens 63-67 14536032-4 2003 Dityrosine crosslink formation was obtained in copper-mediated NF-L aggregates. Copper 47-53 neurofilament light chain Homo sapiens 63-67 14536032-5 2003 The copper-mediated modification of NF-L was significantly inhibited by thiol antioxidants, Nacetylcysteine, glutathione, and thiourea. Copper 4-10 neurofilament light chain Homo sapiens 36-40 14536032-5 2003 The copper-mediated modification of NF-L was significantly inhibited by thiol antioxidants, Nacetylcysteine, glutathione, and thiourea. Sulfhydryl Compounds 72-77 neurofilament light chain Homo sapiens 36-40 14536032-5 2003 The copper-mediated modification of NF-L was significantly inhibited by thiol antioxidants, Nacetylcysteine, glutathione, and thiourea. Acetylcysteine 92-107 neurofilament light chain Homo sapiens 36-40 14536032-5 2003 The copper-mediated modification of NF-L was significantly inhibited by thiol antioxidants, Nacetylcysteine, glutathione, and thiourea. Glutathione 109-120 neurofilament light chain Homo sapiens 36-40 14536032-5 2003 The copper-mediated modification of NF-L was significantly inhibited by thiol antioxidants, Nacetylcysteine, glutathione, and thiourea. Thiourea 126-134 neurofilament light chain Homo sapiens 36-40 14536032-6 2003 A thioflavin-T binding assay was performed to determine whether the copper/H2O2 system-induced in vitro aggregation of NF-L displays amyloid-like characteristics. thioflavin T 2-14 neurofilament light chain Homo sapiens 119-123 14536032-6 2003 A thioflavin-T binding assay was performed to determine whether the copper/H2O2 system-induced in vitro aggregation of NF-L displays amyloid-like characteristics. Copper 68-74 neurofilament light chain Homo sapiens 119-123 14536032-6 2003 A thioflavin-T binding assay was performed to determine whether the copper/H2O2 system-induced in vitro aggregation of NF-L displays amyloid-like characteristics. Hydrogen Peroxide 75-79 neurofilament light chain Homo sapiens 119-123 14536032-7 2003 The aggregate of NF-L displayed thioflavin T reactivity, which was reminiscent of amyloid. thioflavin T 32-42 neurofilament light chain Homo sapiens 17-21 14536032-8 2003 This study suggests that copper-mediated NF-L modification might be closely related to oxidative reactions which may play a critical role in neurodegenerative diseases. Copper 25-31 neurofilament light chain Homo sapiens 41-45 15361639-0 2003 Phase II clinical trial of 5-fluorouracil, trimetrexate, and leucovorin (NFL) in patients with advanced pancreatic cancer. Leucovorin 61-71 neurofilament light chain Homo sapiens 73-76 15361639-3 2003 Preclinical studies suggest synergism between trimetrexate (TMTX),5-FU, and leucovorin (NFL). Leucovorin 76-86 neurofilament light chain Homo sapiens 88-91 12477167-2 2002 A new method, which can detect basepair mismatches with RNase cleavage on agarose gel electrophoresis, coupled with DNA sequencing, identified 8 novel sequence variations in the NF-L gene. Sepharose 74-81 neurofilament light chain Homo sapiens 178-182 12216110-6 2002 8-Cl-adenosine treatment up-regulated genes involved in differentiation and development (LIM protein, connexin 26, neogenin, neurofilament triplet L protein and p21(WAF1/CIP1)) and immune response such as natural killer cells protein 4, and down-regulated ones involved in proliferation and transformation (transforming growth factor-beta, DYRK2, urokinase-type plasminogen activator and proteins involved in transcription and translation) which were in close parallel with those by 8-Cl-cAMP. 8-chloroadenosine 0-14 neurofilament light chain Homo sapiens 125-156 12217642-7 2002 Lysine-rich neurofilament protein subunits NF-H and NF-M are more susceptible than lysine-poor NF-L and beta-tubulin to 1,2-DAB. Lysine 83-89 neurofilament light chain Homo sapiens 95-99 11137063-6 2000 The amount of NF-H and NF-L remaining after proteolysis was determined by SDS-PAGE and quantitative immunoblotting. Sodium Dodecyl Sulfate 74-77 neurofilament light chain Homo sapiens 23-27 12027829-6 2002 CSF sulphatide correlated positively with the amount of DWMH (P < 0.05) while NFL was correlated to both PVH and DWMH (P < 0.05). dwmh 116-120 neurofilament light chain Homo sapiens 81-84 10393846-4 1999 BrdU labeling was decreased in cells expressing presenilin-1 (PS1), presenilin-2 (PS2), an Alzheimer"s disease-associated missense mutation PS2(N141I), and the carboxyl-terminally deleted PS2 construct PS2(166aa), compared with mock and neurofilament-light (NF-L) transfected cells. Bromodeoxyuridine 0-4 neurofilament light chain Homo sapiens 258-262 9826787-7 1998 Transcription from RNAP II and the neuron-specific NFL gene in the presence of aluminum was found to be particularly affected. Aluminum 79-87 neurofilament light chain Homo sapiens 51-54 9702182-7 1998 The sugar-dependent incorporation of N alpha-formyl-[U-14C]-L-lysine ([U-14C]Nfl) into proteins, gave values of 1.5 nMol mg-1 protein after 3 weeks with 100 mM glucose compared to 11 nMol mg-1 protein with 10 mM ascorbate. Sugars 4-9 neurofilament light chain Homo sapiens 77-80 9675103-2 1998 Of the three NF subunits, only NFL demonstrated consistent nitrotyrosine immunoreactivity on immunoblots against mouse monoclonal anti-nitrotyrosine antibodies. 3-nitrotyrosine 59-72 neurofilament light chain Homo sapiens 31-34 9675103-2 1998 Of the three NF subunits, only NFL demonstrated consistent nitrotyrosine immunoreactivity on immunoblots against mouse monoclonal anti-nitrotyrosine antibodies. 3-nitrotyrosine 135-148 neurofilament light chain Homo sapiens 31-34 9702182-7 1998 The sugar-dependent incorporation of N alpha-formyl-[U-14C]-L-lysine ([U-14C]Nfl) into proteins, gave values of 1.5 nMol mg-1 protein after 3 weeks with 100 mM glucose compared to 11 nMol mg-1 protein with 10 mM ascorbate. u-14c 53-58 neurofilament light chain Homo sapiens 77-80 9702182-7 1998 The sugar-dependent incorporation of N alpha-formyl-[U-14C]-L-lysine ([U-14C]Nfl) into proteins, gave values of 1.5 nMol mg-1 protein after 3 weeks with 100 mM glucose compared to 11 nMol mg-1 protein with 10 mM ascorbate. Lysine 60-68 neurofilament light chain Homo sapiens 77-80 9702182-7 1998 The sugar-dependent incorporation of N alpha-formyl-[U-14C]-L-lysine ([U-14C]Nfl) into proteins, gave values of 1.5 nMol mg-1 protein after 3 weeks with 100 mM glucose compared to 11 nMol mg-1 protein with 10 mM ascorbate. -formyl- 44-52 neurofilament light chain Homo sapiens 77-80 9702182-7 1998 The sugar-dependent incorporation of N alpha-formyl-[U-14C]-L-lysine ([U-14C]Nfl) into proteins, gave values of 1.5 nMol mg-1 protein after 3 weeks with 100 mM glucose compared to 11 nMol mg-1 protein with 10 mM ascorbate. u-14c 71-76 neurofilament light chain Homo sapiens 77-80 9702182-7 1998 The sugar-dependent incorporation of N alpha-formyl-[U-14C]-L-lysine ([U-14C]Nfl) into proteins, gave values of 1.5 nMol mg-1 protein after 3 weeks with 100 mM glucose compared to 11 nMol mg-1 protein with 10 mM ascorbate. Glucose 160-167 neurofilament light chain Homo sapiens 77-80 9702182-7 1998 The sugar-dependent incorporation of N alpha-formyl-[U-14C]-L-lysine ([U-14C]Nfl) into proteins, gave values of 1.5 nMol mg-1 protein after 3 weeks with 100 mM glucose compared to 11 nMol mg-1 protein with 10 mM ascorbate. Ascorbic Acid 212-221 neurofilament light chain Homo sapiens 77-80 9349538-4 1997 Neurofilament-L (NF-L), one of the most abundant proteins in motor neurons, bound multiple zinc atoms with sufficient affinity to potentially remove zinc from both wild-type and mutant SOD while having a lower affinity for copper. Copper 223-229 neurofilament light chain Homo sapiens 0-15 9702182-9 1998 N alpha-formyl-N epsilon-fructosyllysine (1.0 mM) dissociated to cause the incorporation of 1.2 nMol of [U-14C]NfL, but 1.0 mM 3-deoxyglucosone, the putative active dissociation product of fructosyl-lysine, produced only 1.5 nMol mg-1 protein of crosslinks. alpha-N-formyl-(epsilon-N-1-deoxy-1-fructosyl)-L-lysine 0-40 neurofilament light chain Homo sapiens 111-114 9702182-9 1998 N alpha-formyl-N epsilon-fructosyllysine (1.0 mM) dissociated to cause the incorporation of 1.2 nMol of [U-14C]NfL, but 1.0 mM 3-deoxyglucosone, the putative active dissociation product of fructosyl-lysine, produced only 1.5 nMol mg-1 protein of crosslinks. u-14c 105-110 neurofilament light chain Homo sapiens 111-114 9388258-5 1997 Combining this method with Western blot analysis, disulfide cross-linking, and SDS-polyacrylamide gel electrophoresis in the second dimension showed that NFL readily forms significant amounts of heterodimer with NFH, NFM, alpha-internexin, or peripherin in the presence of 2 M urea. Disulfides 50-59 neurofilament light chain Homo sapiens 154-157 9388258-5 1997 Combining this method with Western blot analysis, disulfide cross-linking, and SDS-polyacrylamide gel electrophoresis in the second dimension showed that NFL readily forms significant amounts of heterodimer with NFH, NFM, alpha-internexin, or peripherin in the presence of 2 M urea. Sodium Dodecyl Sulfate 79-82 neurofilament light chain Homo sapiens 154-157 9388258-5 1997 Combining this method with Western blot analysis, disulfide cross-linking, and SDS-polyacrylamide gel electrophoresis in the second dimension showed that NFL readily forms significant amounts of heterodimer with NFH, NFM, alpha-internexin, or peripherin in the presence of 2 M urea. polyacrylamide 83-97 neurofilament light chain Homo sapiens 154-157 9388258-5 1997 Combining this method with Western blot analysis, disulfide cross-linking, and SDS-polyacrylamide gel electrophoresis in the second dimension showed that NFL readily forms significant amounts of heterodimer with NFH, NFM, alpha-internexin, or peripherin in the presence of 2 M urea. Urea 277-281 neurofilament light chain Homo sapiens 154-157 9460335-1 1997 New clinical strategies and innovative approaches to the use of mitoxantrone include high-dose treatment, new combinations such as 5-fluorouracil with leucovorin (NFL), and neoadjuvant therapy for metastatic and primary breast cancer. Mitoxantrone 64-76 neurofilament light chain Homo sapiens 163-166 9460336-0 1997 Mitoxantrone, 5-fluorouracil and high-dose leucovorin (NFL) in the treatment of metastatic breast cancer: randomized comparison to cyclophosphamide, methotrexate and 5-fluorouracil (CMF) and attempts to improve efficacy by adding paclitaxel. Leucovorin 43-53 neurofilament light chain Homo sapiens 55-58 9349538-4 1997 Neurofilament-L (NF-L), one of the most abundant proteins in motor neurons, bound multiple zinc atoms with sufficient affinity to potentially remove zinc from both wild-type and mutant SOD while having a lower affinity for copper. Copper 223-229 neurofilament light chain Homo sapiens 17-21 9189892-1 1997 NEUROFILAMENT (NF) proteins, the major components of the neuronal cytoskeleton, have been shown to represent previously unknown targets for the chronic effects of morphine in rats. Morphine 163-171 neurofilament light chain Homo sapiens 0-13 9148897-9 1997 Serine 55 in NF-L was not found to be phosphorylated, which confirms the possible role of phosphorylation and dephosphorylation of this site in early neurofilament assembly. Serine 0-6 neurofilament light chain Homo sapiens 13-17 9387884-5 1997 When RA-treated aggregates of P19 cells were cultured under conditions permissive for neurite outgrowth, we observed a significant increase in the amount of detectable NF-L protein localized within morphologically distinct neurons. Tretinoin 5-7 neurofilament light chain Homo sapiens 168-172 9189892-2 1997 This study was designed to evaluate the abundance of immunoreactive NF-L (68 kDa) proteins in post-mortem brains of chronic opiate addicts who had died of a heroin or methadone overdose. Methadone 167-176 neurofilament light chain Homo sapiens 68-72 8702840-2 1996 NF-M and NF-L are known to be modified by O-linked N-acetylglucosamine (O-GlcNAc) (Dong, D. o-linked n-acetylglucosamine 42-70 neurofilament light chain Homo sapiens 9-13 9037314-3 1997 Ewing"s sarcoma cells also exhibited the potential for neural differentiation at the mRNA level; neuron-specific medium- and low-sized filament (NF-M and NF-L) expression was induced by dibutyryladenosine cyclic monophosphate. Bucladesine 186-225 neurofilament light chain Homo sapiens 154-158 8863506-5 1996 Treatment of cells containing neurofilament accumulations with bisindolylmaleimide, a specific protein kinase C inhibitor, resulted in regeneration of the filamentous network; this effect was not due to a change in the level of transfected NF-L expression. bisindolylmaleimide 63-82 neurofilament light chain Homo sapiens 240-244 9024712-0 1997 Mitoxantrone, 5-fluorouracil, and high dose leucovorin (NFL) versus intravenous cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) in first-line chemotherapy for patients with metastatic breast carcinoma: a randomized phase II trial. Leucovorin 44-54 neurofilament light chain Homo sapiens 56-59 9024712-1 1997 BACKGROUND: Previous Phase II studies using the combination of mitoxantrone, 5-fluorouracil, and high dose leucovorin (NFL) in the treatment of metastatic breast carcinoma have shown this regimen to be active and well tolerated. Leucovorin 107-117 neurofilament light chain Homo sapiens 119-122 8899653-7 1996 This strongly supports the notion that peroxynitrite deranges NF phosphorylation and assembly, by nitrating tyrosine residues in NF-L. Peroxynitrous Acid 39-52 neurofilament light chain Homo sapiens 129-133 8899653-7 1996 This strongly supports the notion that peroxynitrite deranges NF phosphorylation and assembly, by nitrating tyrosine residues in NF-L. Tyrosine 108-116 neurofilament light chain Homo sapiens 129-133 7929561-7 1994 Immunoelectron microscopy investigations of the incorporation sites of NF-H labeled with biotin compounds also revealed the lateral insertion of NF-H subunits into the preexisting NF array, taking after the pattern seen in the case of NF-L. Biotin 89-95 neurofilament light chain Homo sapiens 235-239 8670258-0 1996 cAMP-dependent phosphorylation of neurofilament proteins NF-L and NF-M inhibits their coassembly into filaments in vitro. Cyclic AMP 0-4 neurofilament light chain Homo sapiens 57-61 8670258-1 1996 The effects of cAMP-dependent phosphorylation of neurofilament proteins NF-L and NF-M on the coassembly of the two proteins into filaments in vitro was examined. Cyclic AMP 15-19 neurofilament light chain Homo sapiens 72-76 8381895-2 1993 This morphological change was accompanied by a 5-fold increase in the neurofilament (NF)-L and a 10-fold increase in the NF-M mRNA levels after 24 h. The addition of a protein kinase inhibitor, H-7 (1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride) also induced the extension of neurite-like processes; however, it did not increase the NF mRNA levels. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 194-197 neurofilament light chain Homo sapiens 70-90 7991216-0 1994 Dimethylhexanedione impairs the movement of neurofilament protein subunits, NFM and NFL, in the optic system. dimethylhexanedione 0-19 neurofilament light chain Homo sapiens 84-87 7991216-8 1994 In contrast, in DMHD-treated animals, the radiolabeled NFL and NFM remained near their position at the start of intoxication, retaining a peak of radiolabeled protein. 3,4-dimethyl-2,5-hexanedione 16-20 neurofilament light chain Homo sapiens 55-58 8294936-0 1994 Changes in neurofilament protein NF-L and NF-H immunoreactivity following kainic acid-induced seizures. Kainic Acid 74-85 neurofilament light chain Homo sapiens 33-37 8294936-5 1994 Decreases in NF-L and phosphorylated NF-H contents in the limbic structure at 3 days were correlated with the increasing kainic acid doses from 2.5 to 10 mg/kg. Kainic Acid 121-132 neurofilament light chain Homo sapiens 13-17 8294936-6 1994 The degradation pattern in immunoblots with antibodies against NF-L indicated that the decrease in NF-L was probably due to calcium-activated proteolysis. Calcium 124-131 neurofilament light chain Homo sapiens 63-67 8294936-6 1994 The degradation pattern in immunoblots with antibodies against NF-L indicated that the decrease in NF-L was probably due to calcium-activated proteolysis. Calcium 124-131 neurofilament light chain Homo sapiens 99-103 8019002-1 1994 Phosphorylation of neurofilament-L protein (NF-L) by the catalytic subunit of cAMP-dependent protein kinase (A-kinase) inhibits the reassembly of NF-L and disassembles filamentous NF-L. Cyclic AMP 78-82 neurofilament light chain Homo sapiens 19-42 8019002-1 1994 Phosphorylation of neurofilament-L protein (NF-L) by the catalytic subunit of cAMP-dependent protein kinase (A-kinase) inhibits the reassembly of NF-L and disassembles filamentous NF-L. Cyclic AMP 78-82 neurofilament light chain Homo sapiens 44-48 8019002-1 1994 Phosphorylation of neurofilament-L protein (NF-L) by the catalytic subunit of cAMP-dependent protein kinase (A-kinase) inhibits the reassembly of NF-L and disassembles filamentous NF-L. Cyclic AMP 78-82 neurofilament light chain Homo sapiens 146-150 8019002-1 1994 Phosphorylation of neurofilament-L protein (NF-L) by the catalytic subunit of cAMP-dependent protein kinase (A-kinase) inhibits the reassembly of NF-L and disassembles filamentous NF-L. Cyclic AMP 78-82 neurofilament light chain Homo sapiens 146-150 8344946-4 1993 In purified neurofilament proteins, the O-GlcNAc modifications occur at a stoichiometry of approximately 0.1 and 0.15 mol of GlcNAc/mol of NF-L and NF-M, respectively. Acetylglucosamine 42-48 neurofilament light chain Homo sapiens 139-143 8344946-5 1993 The predominant sites of O-GlcNAc attachment on NF-L and NF-M are identified using proteolysis, purification of the glycopeptides, and subsequent analysis by automated gas-phase sequencing, manual Edman degradation, and laser desorption mass spectrometry. Glycopeptides 116-129 neurofilament light chain Homo sapiens 48-52 8381895-2 1993 This morphological change was accompanied by a 5-fold increase in the neurofilament (NF)-L and a 10-fold increase in the NF-M mRNA levels after 24 h. The addition of a protein kinase inhibitor, H-7 (1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride) also induced the extension of neurite-like processes; however, it did not increase the NF mRNA levels. H-7 dihydrochloride 199-260 neurofilament light chain Homo sapiens 70-90 2121904-2 1990 Calpain-mediated proteolysis of NF-L, tubulin, and glial fibrillary acidic protein (GFAP), three substrates that displayed constant digestion rates in vitro, was inhibited by AlCl3 (IC50 = 200 microM) and by aluminum lactate (IC50 = 400 microM). Aluminum Chloride 175-180 neurofilament light chain Homo sapiens 32-36 1724469-4 1991 35S-labeled cDNA probes for the low molecular weight neurofilament protein (NF-L) mRNA and an alpha-tubulin mRNA species (M alpha 1) were used for in situ hybridizations of sections of the sensorimotor cortex obtained 2, 7, and 14 days after unilateral axotomy of the corticospinal tract in the caudal medulla. Sulfur-35 0-3 neurofilament light chain Homo sapiens 53-74 1724469-4 1991 35S-labeled cDNA probes for the low molecular weight neurofilament protein (NF-L) mRNA and an alpha-tubulin mRNA species (M alpha 1) were used for in situ hybridizations of sections of the sensorimotor cortex obtained 2, 7, and 14 days after unilateral axotomy of the corticospinal tract in the caudal medulla. Sulfur-35 0-3 neurofilament light chain Homo sapiens 76-80 1958811-4 1991 We report here that RB amino acids 307-435 shows similarity to the rod domain of the neurofilament L-type subunit (NF-L). rb amino acids 20-34 neurofilament light chain Homo sapiens 85-113 1958811-4 1991 We report here that RB amino acids 307-435 shows similarity to the rod domain of the neurofilament L-type subunit (NF-L). rb amino acids 20-34 neurofilament light chain Homo sapiens 115-119 2121904-2 1990 Calpain-mediated proteolysis of NF-L, tubulin, and glial fibrillary acidic protein (GFAP), three substrates that displayed constant digestion rates in vitro, was inhibited by AlCl3 (IC50 = 200 microM) and by aluminum lactate (IC50 = 400 microM). aluminum lactate 208-224 neurofilament light chain Homo sapiens 32-36 2108674-1 1990 Protein kinase C phosphorylated the major mammalian neurofilament protein (NF-L) with approximately 3 mol phosphate per mol protein. Phosphates 106-115 neurofilament light chain Homo sapiens 75-79 2357230-2 1990 Phosphorylation of unassembled NF-L in a low ionic strength buffer by cyclic AMP dependent protein kinase led to the incorporation of 1-2 phosphate groups/mole protein. Phosphates 138-147 neurofilament light chain Homo sapiens 31-35 24202576-14 1990 (6) Aluminum experimentally applied to rabbit CNS induces a marked reduction in NF-L mRNA in anterior horn cells (Mumaet al., 1988). Aluminum 4-12 neurofilament light chain Homo sapiens 80-84 2313698-8 1990 NF-L assembled into short intermediate-sized filaments upon dialysis against a low-salt solution containing 1 to 2 mM-MgCl2 at 4 degrees C. The majority of these short filaments possessed four or five-beaded segments, suggesting that the pair of rods were arranged in a half-staggered fashion in neurofilaments. Salts 83-87 neurofilament light chain Homo sapiens 0-4 2313698-8 1990 NF-L assembled into short intermediate-sized filaments upon dialysis against a low-salt solution containing 1 to 2 mM-MgCl2 at 4 degrees C. The majority of these short filaments possessed four or five-beaded segments, suggesting that the pair of rods were arranged in a half-staggered fashion in neurofilaments. Magnesium Chloride 118-123 neurofilament light chain Homo sapiens 0-4 2313699-5 1990 NF-L in 6 M-urea took the form of spherical particles with a diameter of about 12 nm. Urea 12-16 neurofilament light chain Homo sapiens 0-4 2313699-6 1990 NF-L aggregated into rodlets of 70 to 80 nm long in a low-salt solution at alkaline pH. Salts 58-62 neurofilament light chain Homo sapiens 0-4 2313699-13 1990 By dialyzing NF-L against a buffer containing 50 mM-NaCl in the absence of Mg2+, unraveled filaments were formed. Sodium Chloride 52-56 neurofilament light chain Homo sapiens 13-17 34964348-8 2021 A 10 mug/m3 increase in PM2.5 concentration was associated with 2.09% (95% CI, 39.3-76.5%), 100% (95% CI, 1.73-198%), and 122% (95% CI, 20.7-222%) increments in BDNF, NfL, and PGP9.5, respectively. pm2.5 24-29 neurofilament light chain Homo sapiens 167-170 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Tin 45-47 neurofilament light chain Homo sapiens 130-133 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Copper 29-31 neurofilament light chain Homo sapiens 130-133 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Vanadium 49-50 neurofilament light chain Homo sapiens 130-133 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Zinc 33-35 neurofilament light chain Homo sapiens 130-133 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Rubidium 52-54 neurofilament light chain Homo sapiens 130-133 34992970-3 2021 CSF NfL levels were 1.26 SDs higher in the APS group compared to the PD group (g = 1.26 (95% confidence interval 0.99-1.53)), and circulating NfL levels were 1.53 SDs higher in the APS group compared to the PD group (g = 1.53 (95% confidence interval 1.15-1.91)); 4 studies, 307 patients with PD, 197 patients with APS. Sodium Dodecyl Sulfate 25-28 neurofilament light chain Homo sapiens 4-7 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Lead 56-58 neurofilament light chain Homo sapiens 130-133 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Aluminum 60-62 neurofilament light chain Homo sapiens 130-133 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Beryllium 64-66 neurofilament light chain Homo sapiens 130-133 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Cesium 68-70 neurofilament light chain Homo sapiens 130-133 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Cobalt 72-74 neurofilament light chain Homo sapiens 130-133 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Thorium 76-78 neurofilament light chain Homo sapiens 130-133 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Uranium 80-81 neurofilament light chain Homo sapiens 130-133 34964348-9 2021 Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl-, and F- were significantly associated with NfL. Fluorine 92-94 neurofilament light chain Homo sapiens 130-133 34874540-10 2022 In multivariable regression analysis, higher CSF NfL Z-score was statistically significantly associated with older age and higher CSF protein, and higher plasma NfL Z-score with older age, higher serum creatinine and lower bodyweight. Creatinine 202-212 neurofilament light chain Homo sapiens 49-52 34924923-2 2021 We assessed whether NfL and other biomarker levels in the CSF are correlated to the loss of presynaptic dopamine transporters in neurons as detected with dopamine transporter SPECT (DaTscan). Dopamine 104-112 neurofilament light chain Homo sapiens 20-23 34786556-10 2021 Patients receiving DMTs showed decreased levels of anti-NfL (p=0.008), high-avidity antibodies (p=0.017) and immune-complexes compared with untreated CIS/RRMS. Dimethyl trisulfide 19-23 neurofilament light chain Homo sapiens 56-59 34866692-6 2021 Supplementary citicoline treatment provided significant reductions of the levels of GFAP (33%, P = 0.034), NF-L (27%, P = 0.019), and MBP (32%, P = 0.018), as compared to the initial values, while there were no marked changes in the studied parameters in the control group. Cytidine Diphosphate Choline 14-24 neurofilament light chain Homo sapiens 107-111 34800169-9 2022 RESULTS: Age-adjusted linear regression analyses revealed increased plasma NfL concentrations with increasing creatinine (beta = 0.01, p < 0.001) and Q-albumin (beta = 0.07, p = 0.008). Creatinine 110-120 neurofilament light chain Homo sapiens 75-78 34800169-13 2022 However, plasma NfL was also influenced by other factors, such as damage accrual, creatinine, and Q-albumin, thereby obscuring the interpretation of how plasma NfL reflects CNS involvement. Creatinine 82-92 neurofilament light chain Homo sapiens 16-19 34718678-6 2022 High sensitivity C-reactive protein (hsCRP), serum total cholesterol, and resting heart rate at v1 were linked with faster plasma NfL over-time increase overall, while being uncorrelated with NfLv1 (e.g. hsCRPxTIME, full model: gamma11 = +0.004+-0.002, P = 0.015). Cholesterol 57-68 neurofilament light chain Homo sapiens 130-133 34858161-3 2021 Different types of potassium salts of EDTA and different centrifugation temperatures during plasma preparation may affect the results of alpha-synuclein and NFL measurements. potassium salts 19-34 neurofilament light chain Homo sapiens 157-160 34858161-3 2021 Different types of potassium salts of EDTA and different centrifugation temperatures during plasma preparation may affect the results of alpha-synuclein and NFL measurements. Edetic Acid 38-42 neurofilament light chain Homo sapiens 157-160 34877240-9 2021 There was a significant positive correlation between NfL and globotriaosylosphingosine (lyso-Gb3) concentration in women with FD (R = 0,69, p = 0.01). globotriaosylosphingosine 61-86 neurofilament light chain Homo sapiens 53-56 34877240-9 2021 There was a significant positive correlation between NfL and globotriaosylosphingosine (lyso-Gb3) concentration in women with FD (R = 0,69, p = 0.01). globotriaosyl lysosphingolipid 88-96 neurofilament light chain Homo sapiens 53-56 34523725-5 2021 For this secondary data analysis, we proposed a conceptual model linking alcohol consumption, the pro-inflammatory cytokine IL-6, brain structure and NfL in heavy-drinking participants. Alcohols 73-80 neurofilament light chain Homo sapiens 150-153 34488043-9 2021 CONCLUSIONS: Serum NFL may complement established clinical and imaging predictors of treatment response and functional outcome in stroke patients undergoing EVT for acLVO. EVT 157-160 neurofilament light chain Homo sapiens 19-22 34511123-7 2021 RESULTS: Of the 180 blood samples from the 60 patients who received EVT, the plasma NfL, GFAP, and UCHL1 levels at T1 were significantly higher than those of the controls, and the levels of all four biomarkers were significantly higher at T3. EVT 68-71 neurofilament light chain Homo sapiens 84-87 34611039-5 2021 RESULTS: Nf-L was detected in all CSF samples (median (range) = 575 (791.8-2,349) pg/mL) and positively correlated with markers of inflammation (CXCL10 (r = 0.733), neopterin (r = 0.499), cell count (r = 0.403), and protein levels (r = 0.693) in CSF; p < 0.0015). Neopterin 165-174 neurofilament light chain Homo sapiens 9-13 34611039-9 2021 Nf-L in plasma correlated with concentration of Nf-L, neopterin, CXCL10, and protein in CSF. Neopterin 54-63 neurofilament light chain Homo sapiens 0-4 35585374-7 2022 Informed by Pre-fALS and the tofersen clinical development program, the ATLAS study (NCT04856982) is designed to evaluate the impact of initiating tofersen in presymptomatic carriers of SOD1 variants associated with high or complete penetrance and rapid disease progression who also have biomarker evidence of disease activity (elevated plasma NfL). tofersen 147-155 neurofilament light chain Homo sapiens 344-347 34392718-5 2022 RESULTS: RRMS with relapse had 4.4 times higher median cNFL concentration (1134 (interquartile range (IQR) 499-2744) ng/L) than those without relapse (264 (125-537) ng/L, p < 0.001) and patients with gadolinium-enhancing lesions had 3.3 times higher median NFL (1414 (606.8-3210) ng/L) than those without (426 (IQR 221-851) ng/L, p < 0.001). Gadolinium 200-210 neurofilament light chain Homo sapiens 257-260 34188109-7 2021 Among the AD SCA patients, there was a positive correlation between the serum NfL level and the trinucleotide repeat number (r = 0.47, p-value = 0.001), disease duration (r = 0.35, p-value = 0.019), disease duration/age x trinucleotide repeat number (r = 0.330, p-value = 0.021), and SARA score (n = 33; r = 0.37, p-value = 0.033). trinucleotide 96-109 neurofilament light chain Homo sapiens 78-81 34188109-7 2021 Among the AD SCA patients, there was a positive correlation between the serum NfL level and the trinucleotide repeat number (r = 0.47, p-value = 0.001), disease duration (r = 0.35, p-value = 0.019), disease duration/age x trinucleotide repeat number (r = 0.330, p-value = 0.021), and SARA score (n = 33; r = 0.37, p-value = 0.033). trinucleotide 222-235 neurofilament light chain Homo sapiens 78-81 35533500-3 2022 We undertook an exploratory observational study to determine the association between plasma NfL and delirium in the critically ill. METHODS: MoDUS was a randomised placebo-controlled delirium trial of simvastatin done in an UK adult general ICU. Simvastatin 201-212 neurofilament light chain Homo sapiens 92-95 34429340-1 2021 BACKGROUND AND OBJECTIVE: To study whether dimethyl fumarate is superior to placebo in decreasing CSF concentrations of neurofilament light chain (NFL) in patients with primary progressive MS (PPMS). Dimethyl Fumarate 43-60 neurofilament light chain Homo sapiens 147-150 34131052-6 2021 In one hundred hospitalized patients with COVID-19 treated with remdesivir, a trend toward lower NFL serum concentrations was observed. remdesivir 64-74 neurofilament light chain Homo sapiens 97-100 35420371-2 2022 Cytoskeletal structures such as neurofilament light chain (NfL) are promising markers of drug-induced brain toxicity and may be involved in MDMA neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 140-144 neurofilament light chain Homo sapiens 59-62 35420371-4 2022 However, the role of BDNF pre-treatment in preventing MDMA neurotoxicity and the potential effects of MDMA on NfL are still elusive. N-Methyl-3,4-methylenedioxyamphetamine 102-106 neurofilament light chain Homo sapiens 110-113 35420371-6 2022 Cell viability (measured by MTT) and intracellular NfL levels (immunocytochemistry assay) were reduced by MDMA, but partially rescued by BDNF co-treatment. N-Methyl-3,4-methylenedioxyamphetamine 106-110 neurofilament light chain Homo sapiens 51-54 35420371-8 2022 We also provide evidence on the sensitivity of NfL to MDMA neurotoxicity, with potential implications for in-vivo monitoring of drug-induced neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 54-58 neurofilament light chain Homo sapiens 47-50 35256615-5 2022 NfL also discriminated the smcTBI group from IC (AUC:77.5%, p < 0.001) and mTBI (AUC:76.1%, p < 0.001) groups. smctbi 27-33 neurofilament light chain Homo sapiens 0-3 35466956-7 2022 RESULTS: Baseline plasma NfL was a significant predictor of psychotic symptoms longitudinally across the study adjusted for age, Hoehn and Yahr stage, duration of follow up, duration of disease, baseline levodopa and dopamine agonist medication, and baseline cognition: (OR 8.15 (95% CI 1.40-47.4), p = 0.020). Levodopa 204-212 neurofilament light chain Homo sapiens 25-28 35466956-7 2022 RESULTS: Baseline plasma NfL was a significant predictor of psychotic symptoms longitudinally across the study adjusted for age, Hoehn and Yahr stage, duration of follow up, duration of disease, baseline levodopa and dopamine agonist medication, and baseline cognition: (OR 8.15 (95% CI 1.40-47.4), p = 0.020). Dopamine 217-225 neurofilament light chain Homo sapiens 25-28 35131644-6 2022 Finally, two general linear models were used to examine the predictive values of neurofilament light-chain (NfL) serum levels on (1) total lesion burden or (2) PVC (18F)DPA-714 VT of lesions showing elevated inflammation. dpa 169-172 neurofilament light chain Homo sapiens 108-111 35242574-7 2022 Levels of the axonal damage marker Neurofilament light (NF-L) were highly elevated in both GM2 and GM1 gangliosidosis patient plasma samples, with no overlap with controls. gm2 91-94 neurofilament light chain Homo sapiens 56-60 35197833-0 2022 Neurofilament Light Chain as a Biomarker for Monitoring the Efficacy of Transcranial Magnetic Stimulation on Alcohol Use Disorder. Alcohols 109-116 neurofilament light chain Homo sapiens 0-25 35197833-10 2022 Serum NfL levels may be useful as an early serological indicator of alcohol-induced brain injury. Alcohols 68-75 neurofilament light chain Homo sapiens 6-9 35242574-9 2022 In GM2 gangliosidosis patient plasma NF-L, Tau, GFAP and lysoGM2 were all most highly elevated in infantile onset patients, indicating a relationship to severity and phenotype. gm2 3-6 neurofilament light chain Homo sapiens 37-41 35242574-11 2022 These results indicate that lysosphingolipids and NF-L/GFAP have potential to monitor pharmacodynamics and pathogenic processes respectively in GM2 and GM1 gangliosidoses patients. gm2 144-147 neurofilament light chain Homo sapiens 50-54 35242574-11 2022 These results indicate that lysosphingolipids and NF-L/GFAP have potential to monitor pharmacodynamics and pathogenic processes respectively in GM2 and GM1 gangliosidoses patients. G(M1) Ganglioside 152-155 neurofilament light chain Homo sapiens 50-54 35603281-5 2022 Here, we leveraged a set of features using GFT that quantified the coupling between blood oxygen level dependent signals and structural connectome to investigate their associations with serum NfL levels collected from healthy subjects and former athletes with history of concussions. Oxygen 90-96 neurofilament light chain Homo sapiens 192-195 35126292-12 2021 The age by CTG interaction predicted NF-L: patients with higher estimated progenitor allelege length (ePAL) had higher NF-L at a younger age, relative to patients with lower CTG repeat; however, the latter exhibited faster age-related change (Estimate = -0.0021, 95% CI -0.0042: -0.0001, P = 0.045). ctg 11-14 neurofilament light chain Homo sapiens 37-41 35126292-12 2021 The age by CTG interaction predicted NF-L: patients with higher estimated progenitor allelege length (ePAL) had higher NF-L at a younger age, relative to patients with lower CTG repeat; however, the latter exhibited faster age-related change (Estimate = -0.0021, 95% CI -0.0042: -0.0001, P = 0.045). ctg 11-14 neurofilament light chain Homo sapiens 119-123 34996525-7 2022 RESULTS: The Kaplan-Meier analysis showed association between the serum NFL tertiles and risk of cognitive stage transition in MCI (P = 0.002) and CU (P = 0.028) participants, analyzed separately. Copper 147-149 neurofilament light chain Homo sapiens 72-75 35014217-9 2022 Patients showed GDC-0134 exposure-dependent plasma NFL elevations; DLK cKO mice also exhibited plasma NFL compared to wild-type littermates. UNII-4N6KQ7D685 16-24 neurofilament light chain Homo sapiens 51-54 35014217-11 2022 NFL elevations in GDC-0134-treated patients and DLK cKO mice raised questions about interpretation of biomarkers affected by both disease and on-target drug effects. UNII-4N6KQ7D685 18-26 neurofilament light chain Homo sapiens 0-3