PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
35163707-0	2022	miR-196a Upregulation Contributes to Gefitinib Resistance through Inhibiting GLTP Expression.	mir-196a	0-8	glycolipid transfer protein	Homo sapiens	77-81
35163707-0	2022	miR-196a Upregulation Contributes to Gefitinib Resistance through Inhibiting GLTP Expression.	Gefitinib	37-46	glycolipid transfer protein	Homo sapiens	77-81
35163707-7	2022	We also found that glycolipid transfer protein (GLTP) was a functional direct target of miR-196a, and downregulation of GLTP by miR-196a was responsible for gefitinib resistance.	Gefitinib	157-166	glycolipid transfer protein	Homo sapiens	19-46
35163707-7	2022	We also found that glycolipid transfer protein (GLTP) was a functional direct target of miR-196a, and downregulation of GLTP by miR-196a was responsible for gefitinib resistance.	Gefitinib	157-166	glycolipid transfer protein	Homo sapiens	48-52
35163707-7	2022	We also found that glycolipid transfer protein (GLTP) was a functional direct target of miR-196a, and downregulation of GLTP by miR-196a was responsible for gefitinib resistance.	Gefitinib	157-166	glycolipid transfer protein	Homo sapiens	120-124
35163707-8	2022	GLTP overexpression alone was sufficient to increase the sensitivity of lung cancer cells to gefitinib treatment.	Gefitinib	93-102	glycolipid transfer protein	Homo sapiens	0-4
2790046-2	1989	GLTP treated with N-ethylmaleimide (NEM) and Na2S4O6 had a transfer activity of about 70% and 55%, respectively, of the control GLTP.	Ethylmaleimide	36-39	glycolipid transfer protein	Homo sapiens	128-132
2790046-2	1989	GLTP treated with N-ethylmaleimide (NEM) and Na2S4O6 had a transfer activity of about 70% and 55%, respectively, of the control GLTP.	na2s4o6	45-52	glycolipid transfer protein	Homo sapiens	0-4
2790046-2	1989	GLTP treated with N-ethylmaleimide (NEM) and Na2S4O6 had a transfer activity of about 70% and 55%, respectively, of the control GLTP.	na2s4o6	45-52	glycolipid transfer protein	Homo sapiens	128-132
2790046-0	1989	Formation of an intramolecular disulfide bond of glycolipid transfer protein.	Disulfides	31-40	glycolipid transfer protein	Homo sapiens	49-76
31203808-12	2020	GLTP had higher affinity for tocotrienols than tocopherols.	Tocotrienols	29-41	glycolipid transfer protein	Homo sapiens	0-4
2790046-2	1989	GLTP treated with N-ethylmaleimide (NEM) and Na2S4O6 had a transfer activity of about 70% and 55%, respectively, of the control GLTP.	Ethylmaleimide	18-34	glycolipid transfer protein	Homo sapiens	0-4
2790046-2	1989	GLTP treated with N-ethylmaleimide (NEM) and Na2S4O6 had a transfer activity of about 70% and 55%, respectively, of the control GLTP.	Ethylmaleimide	18-34	glycolipid transfer protein	Homo sapiens	128-132
2790046-2	1989	GLTP treated with N-ethylmaleimide (NEM) and Na2S4O6 had a transfer activity of about 70% and 55%, respectively, of the control GLTP.	Ethylmaleimide	36-39	glycolipid transfer protein	Homo sapiens	0-4
32339554-2	2020	Upon discovery that GLTPs use a unique, all-alpha-helical, two-layer "sandwich" architecture (GLTP-fold) to bind glycosphingolipids (GSLs), a new protein superfamily was born.	Glycosphingolipids	113-131	glycolipid transfer protein	Homo sapiens	20-24
32339554-2	2020	Upon discovery that GLTPs use a unique, all-alpha-helical, two-layer "sandwich" architecture (GLTP-fold) to bind glycosphingolipids (GSLs), a new protein superfamily was born.	Glycosphingolipids	133-137	glycolipid transfer protein	Homo sapiens	20-24
32339554-4	2020	In humans, evolutionarily-modified GLTP-folds have been identified with altered sphingolipid specificity, e. g. ceramide-1-phosphate transfer protein (CPTP), phosphatidylinositol 4-phosphate adaptor protein-2 (FAPP2) which harbors a GLTP-domain and GLTPD2.	Sphingolipids	80-92	glycolipid transfer protein	Homo sapiens	35-39
32339554-4	2020	In humans, evolutionarily-modified GLTP-folds have been identified with altered sphingolipid specificity, e. g. ceramide-1-phosphate transfer protein (CPTP), phosphatidylinositol 4-phosphate adaptor protein-2 (FAPP2) which harbors a GLTP-domain and GLTPD2.	Sphingolipids	80-92	glycolipid transfer protein	Homo sapiens	233-237
32339554-4	2020	In humans, evolutionarily-modified GLTP-folds have been identified with altered sphingolipid specificity, e. g. ceramide-1-phosphate transfer protein (CPTP), phosphatidylinositol 4-phosphate adaptor protein-2 (FAPP2) which harbors a GLTP-domain and GLTPD2.	phosphatidylinositol 4-phosphate	158-190	glycolipid transfer protein	Homo sapiens	35-39
32339554-6	2020	In this review, recent advances are presented and discussed implicating human GLTP superfamily members as important regulators of: i) pro-inflammatory eicosanoid production associated with Group-IV cytoplasmic phospholipase A2; ii) autophagy and inflammasome assembly that drive surveillance cell release of interleukin-1beta and interleukin-18 inflammatory cytokines; iii) cell cycle arrest and necroptosis induction in certain colon cancer cell lines.	Eicosanoids	151-161	glycolipid transfer protein	Homo sapiens	78-82
32339554-9	2020	Such avenues include targeted regulation of specific GLTP superfamily members to alter sphingolipid levels as a therapeutic means for combating viral infection, neurodegenerative conditions and circumventing chemo-resistance during cancer treatment.	Sphingolipids	87-99	glycolipid transfer protein	Homo sapiens	53-57
2790046-3	1989	No significant decrease was found in the binding affinity of NEM-treated GLTP to pyrene-labeled galactosylceramide (PyrGalCer).	Ethylmaleimide	61-64	glycolipid transfer protein	Homo sapiens	73-77
2790046-4	1989	A small decrease in the binding affinity was found in the Na2S4O6-treated GLTP.	na2s4o6	58-65	glycolipid transfer protein	Homo sapiens	74-78
2790046-5	1989	Oxidation of NEM-treated and Na2S4O6-treated GLTP catalyzed by CuSO4 resulted in a stoichiometric conversion of the slower component to the faster component.	Ethylmaleimide	13-16	glycolipid transfer protein	Homo sapiens	45-49
2790046-5	1989	Oxidation of NEM-treated and Na2S4O6-treated GLTP catalyzed by CuSO4 resulted in a stoichiometric conversion of the slower component to the faster component.	na2s4o6	29-36	glycolipid transfer protein	Homo sapiens	45-49
2790046-5	1989	Oxidation of NEM-treated and Na2S4O6-treated GLTP catalyzed by CuSO4 resulted in a stoichiometric conversion of the slower component to the faster component.	Copper Sulfate	63-68	glycolipid transfer protein	Homo sapiens	45-49
2790046-9	1989	The transfer activity of the Na2S4O6-treated and oxidized GLTP was 2-fold higher than that of the original GLTP and 3.6-fold higher than that of the Na2S4O6-treated GLTP.	na2s4o6	29-36	glycolipid transfer protein	Homo sapiens	58-62
2790046-9	1989	The transfer activity of the Na2S4O6-treated and oxidized GLTP was 2-fold higher than that of the original GLTP and 3.6-fold higher than that of the Na2S4O6-treated GLTP.	na2s4o6	29-36	glycolipid transfer protein	Homo sapiens	107-111
2790046-9	1989	The transfer activity of the Na2S4O6-treated and oxidized GLTP was 2-fold higher than that of the original GLTP and 3.6-fold higher than that of the Na2S4O6-treated GLTP.	na2s4o6	29-36	glycolipid transfer protein	Homo sapiens	107-111
2790046-9	1989	The transfer activity of the Na2S4O6-treated and oxidized GLTP was 2-fold higher than that of the original GLTP and 3.6-fold higher than that of the Na2S4O6-treated GLTP.	na2s4o6	149-156	glycolipid transfer protein	Homo sapiens	58-62
2790046-10	1989	The binding affinity of the faster components, produced from both the NEM-treated GLTP and the Na2S4O6-treated GLTP, to PyrGalCer was found to be twice that of the respective modified GLTPs before oxidation.	na2s4o6	95-102	glycolipid transfer protein	Homo sapiens	111-115
2790046-12	1989	The results suggest that the formation of an intramolecular disulfide bond results in only a small change in the secondary and tertiary structure of GLTP.	Disulfides	60-69	glycolipid transfer protein	Homo sapiens	149-153
32640984-10	2020	We observed four interactions of interest: GLTP - Nilotinib, PTPRN - Venetoclax, VEGFA - Venetoclax and FABP6 - Abemaciclib.	nilotinib	50-59	glycolipid transfer protein	Homo sapiens	43-47
31203808-12	2020	GLTP had higher affinity for tocotrienols than tocopherols.	Tocopherols	47-58	glycolipid transfer protein	Homo sapiens	0-4
29305831-0	2018	Functional evaluation of tryptophans in glycolipid binding and membrane interaction by HET-C2, a fungal glycolipid transfer protein.	Tryptophan	25-36	glycolipid transfer protein	Homo sapiens	104-131
30472325-1	2019	Human GLTP on chromosome 12 (locus 12q24.11) encodes a 24 kD amphitropic lipid transfer protein (GLTP) that mediates glycosphingolipid (GSL) intermembrane trafficking and regulates GSL homeostatic levels within cells.	Glycosphingolipids	117-134	glycolipid transfer protein	Homo sapiens	6-10
30472325-1	2019	Human GLTP on chromosome 12 (locus 12q24.11) encodes a 24 kD amphitropic lipid transfer protein (GLTP) that mediates glycosphingolipid (GSL) intermembrane trafficking and regulates GSL homeostatic levels within cells.	Glycosphingolipids	117-134	glycolipid transfer protein	Homo sapiens	97-101
30472325-1	2019	Human GLTP on chromosome 12 (locus 12q24.11) encodes a 24 kD amphitropic lipid transfer protein (GLTP) that mediates glycosphingolipid (GSL) intermembrane trafficking and regulates GSL homeostatic levels within cells.	Glycosphingolipids	136-139	glycolipid transfer protein	Homo sapiens	6-10
30472325-1	2019	Human GLTP on chromosome 12 (locus 12q24.11) encodes a 24 kD amphitropic lipid transfer protein (GLTP) that mediates glycosphingolipid (GSL) intermembrane trafficking and regulates GSL homeostatic levels within cells.	Glycosphingolipids	136-139	glycolipid transfer protein	Homo sapiens	97-101
30472325-1	2019	Human GLTP on chromosome 12 (locus 12q24.11) encodes a 24 kD amphitropic lipid transfer protein (GLTP) that mediates glycosphingolipid (GSL) intermembrane trafficking and regulates GSL homeostatic levels within cells.	Glycosphingolipids	181-184	glycolipid transfer protein	Homo sapiens	6-10
30472325-1	2019	Human GLTP on chromosome 12 (locus 12q24.11) encodes a 24 kD amphitropic lipid transfer protein (GLTP) that mediates glycosphingolipid (GSL) intermembrane trafficking and regulates GSL homeostatic levels within cells.	Glycosphingolipids	181-184	glycolipid transfer protein	Homo sapiens	97-101
30472325-5	2019	However, HT-29 cells overexpressing GLTP underwent cell death by necroptosis as revealed by phosphorylation of human mixed lineage kinase domain-like protein (pMLKL) via receptor-interacting protein kinase-3 (RIPK-3), elevated cytosolic calcium, and plasma membrane permeabilization by pMLKL oligomerization.	Calcium	237-244	glycolipid transfer protein	Homo sapiens	36-40
30472325-6	2019	Overexpression of W96A-GLTP, an ablated GSL binding site mutant, failed to arrest the cell cycle or induce necroptosis.	Glycosphingolipids	40-43	glycolipid transfer protein	Homo sapiens	23-27
30790260-0	2019	In Vitro Measurement of Sphingolipid Intermembrane Transport Illustrated by GLTP Superfamily Members.	Sphingolipids	24-36	glycolipid transfer protein	Homo sapiens	76-80
30206120-0	2018	Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family.	4-phosphate	23-34	glycolipid transfer protein	Homo sapiens	117-144
30206120-0	2018	Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family.	Sphingolipids	85-97	glycolipid transfer protein	Homo sapiens	117-144
30206120-1	2018	The glycolipid transfer protein (GLTP) fold defines a superfamily of eukaryotic proteins that selectively transport sphingolipids (SLs) between membranes.	Sphingolipids	116-129	glycolipid transfer protein	Homo sapiens	4-31
30206120-1	2018	The glycolipid transfer protein (GLTP) fold defines a superfamily of eukaryotic proteins that selectively transport sphingolipids (SLs) between membranes.	Sphingolipids	116-129	glycolipid transfer protein	Homo sapiens	33-37
30206120-3	2018	Here, we report the crystal structure of the GLTP homology (GLTPH) domain of human 4-phosphate adaptor protein 2 (FAPP2) bound with N-oleoyl-galactosylceramide.	n-oleoyl-galactosylceramide	132-159	glycolipid transfer protein	Homo sapiens	45-49
30206120-12	2018	In summary, our study provides mechanistic insights into sphingolipid recognition by the GLTP fold and uncovers the elements involved in this recognition.	Sphingolipids	57-69	glycolipid transfer protein	Homo sapiens	89-93
30550553-1	2018	The glycolipid transfer protein, GLTP, can be found in the cytoplasm, and it has a FFAT-like motif (two phenylalanines in an acidic tract) that targets it to the endoplasmic reticulum (ER).	Phenylalanine	104-118	glycolipid transfer protein	Homo sapiens	33-37
30550553-3	2018	We have addressed the mechanisms that might regulate the association between GLTP and the VAP proteins by studying the capacity of GLTP to recognize different N-linked acyl chain species of glucosylceramide.	Nitrogen	159-160	glycolipid transfer protein	Homo sapiens	131-135
30550553-3	2018	We have addressed the mechanisms that might regulate the association between GLTP and the VAP proteins by studying the capacity of GLTP to recognize different N-linked acyl chain species of glucosylceramide.	Glucosylceramides	190-206	glycolipid transfer protein	Homo sapiens	131-135
30550553-4	2018	We used surface plasmon resonance and a lipid transfer competition assay to show that GLTP prefers shorter N-linked fully saturated acyl chain glucosylceramides, such as C8, C12, and C16, whereas long C18, C20, and C24-glucosylceramides are all bound more weakly and transported more slowly than their shorter counterparts.	Nitrogen	107-108	glycolipid transfer protein	Homo sapiens	86-90
30550553-4	2018	We used surface plasmon resonance and a lipid transfer competition assay to show that GLTP prefers shorter N-linked fully saturated acyl chain glucosylceramides, such as C8, C12, and C16, whereas long C18, C20, and C24-glucosylceramides are all bound more weakly and transported more slowly than their shorter counterparts.	chain glucosylceramides	137-160	glycolipid transfer protein	Homo sapiens	86-90
30550553-5	2018	Changes in the intrinsic GLTP tryptophan fluorescence blueshifts, also indicate a break-point between C16- and C18-glucosylceramide in the GLTP sensing ability.	Tryptophan	30-40	glycolipid transfer protein	Homo sapiens	25-29
30550553-5	2018	Changes in the intrinsic GLTP tryptophan fluorescence blueshifts, also indicate a break-point between C16- and C18-glucosylceramide in the GLTP sensing ability.	Tryptophan	30-40	glycolipid transfer protein	Homo sapiens	139-143
30550553-6	2018	It has long been postulated that GLTP would be a sensor in the sphingolipid synthesis machinery, but how this mechanistically occurs has not been addressed before.	Sphingolipids	63-75	glycolipid transfer protein	Homo sapiens	33-37
30550553-9	2018	We have also used a formula for identifying putative FFAT-domains, and we identified several potential VAP-interactors within the ceramide and sphingolipid synthesis pathways that could be candidates for regulation by GLTP.	Ceramides	130-138	glycolipid transfer protein	Homo sapiens	218-222
30550553-9	2018	We have also used a formula for identifying putative FFAT-domains, and we identified several potential VAP-interactors within the ceramide and sphingolipid synthesis pathways that could be candidates for regulation by GLTP.	Sphingolipids	143-155	glycolipid transfer protein	Homo sapiens	218-222
29305831-0	2018	Functional evaluation of tryptophans in glycolipid binding and membrane interaction by HET-C2, a fungal glycolipid transfer protein.	Glycolipids	40-50	glycolipid transfer protein	Homo sapiens	104-131
29305831-1	2018	HET-C2 is a fungal glycolipid transfer protein (GLTP) that uses an evolutionarily-modified GLTP-fold to achieve more focused transfer specificity for simple neutral glycosphingolipids than mammalian GLTPs.	Glycosphingolipids	165-183	glycolipid transfer protein	Homo sapiens	19-46
29305831-1	2018	HET-C2 is a fungal glycolipid transfer protein (GLTP) that uses an evolutionarily-modified GLTP-fold to achieve more focused transfer specificity for simple neutral glycosphingolipids than mammalian GLTPs.	Glycosphingolipids	165-183	glycolipid transfer protein	Homo sapiens	48-52
29305831-1	2018	HET-C2 is a fungal glycolipid transfer protein (GLTP) that uses an evolutionarily-modified GLTP-fold to achieve more focused transfer specificity for simple neutral glycosphingolipids than mammalian GLTPs.	Glycosphingolipids	165-183	glycolipid transfer protein	Homo sapiens	91-95
29305831-2	2018	Only one of HET-C2"s two Trp residues is topologically identical to the three Trp residues of mammalian GLTP.	Tryptophan	78-81	glycolipid transfer protein	Homo sapiens	104-108
28025687-0	2017	Characterisation of the DAACS Family Escherichia coli Glutamate/Aspartate-Proton Symporter GltP Using Computational, Chemical, Biochemical and Biophysical Methods.	daacs	24-29	glycolipid transfer protein	Homo sapiens	91-95
28025687-1	2017	Escherichia coli glutamate/aspartate-proton symporter GltP is a member of the Dicarboxylate/Amino Acid:Cation Symporter family of secondary active transport proteins.	Glutamic Acid	17-26	glycolipid transfer protein	Homo sapiens	54-58
28025687-1	2017	Escherichia coli glutamate/aspartate-proton symporter GltP is a member of the Dicarboxylate/Amino Acid:Cation Symporter family of secondary active transport proteins.	Aspartic Acid	27-36	glycolipid transfer protein	Homo sapiens	54-58
28025687-1	2017	Escherichia coli glutamate/aspartate-proton symporter GltP is a member of the Dicarboxylate/Amino Acid:Cation Symporter family of secondary active transport proteins.	malonic acid	78-91	glycolipid transfer protein	Homo sapiens	54-58
28025687-7	2017	A homology model of GltP docked with L-glutamate identified a putative binding site and residues predicted to interact with substrate.	Glutamic Acid	37-48	glycolipid transfer protein	Homo sapiens	20-24
28025687-9	2017	Residues were investigated by measuring transport activities, kinetics and response to thiol-specific reagents in 42 site-specific mutants compared with cysteine-less GltP (C256A) having an apparent affinity of initial rate transport (K m) for 3H-L-glutamate of 22.6 +- 5.5 muM in energised E. coli cells.	Sulfhydryl Compounds	87-92	glycolipid transfer protein	Homo sapiens	167-171
28025687-9	2017	Residues were investigated by measuring transport activities, kinetics and response to thiol-specific reagents in 42 site-specific mutants compared with cysteine-less GltP (C256A) having an apparent affinity of initial rate transport (K m) for 3H-L-glutamate of 22.6 +- 5.5 muM in energised E. coli cells.	Cysteine	153-161	glycolipid transfer protein	Homo sapiens	167-171
28025687-9	2017	Residues were investigated by measuring transport activities, kinetics and response to thiol-specific reagents in 42 site-specific mutants compared with cysteine-less GltP (C256A) having an apparent affinity of initial rate transport (K m) for 3H-L-glutamate of 22.6 +- 5.5 muM in energised E. coli cells.	3h-l-glutamate	244-258	glycolipid transfer protein	Homo sapiens	167-171
27412675-6	2016	GlcCer inhibited GLTP cross-linking.	Glucosylceramides	0-6	glycolipid transfer protein	Homo sapiens	17-21
28011644-7	2017	Also, none of the anionic phosphoglycerides affected transfer action by human glycolipid lipid transfer protein (GLTP), which is glycolipid-specific and has few cationic residues near its glycolipid binding site.	Glycolipids	78-88	glycolipid transfer protein	Homo sapiens	113-117
28011644-7	2017	Also, none of the anionic phosphoglycerides affected transfer action by human glycolipid lipid transfer protein (GLTP), which is glycolipid-specific and has few cationic residues near its glycolipid binding site.	Glycolipids	129-139	glycolipid transfer protein	Homo sapiens	113-117
28011644-8	2017	These findings provide the first evidence for a potential phosphoglyceride headgroup-specific regulatory interaction site(s) existing on the surface of any GLTP-fold and delineate new differences between GLTP superfamily members that are specific for C1P versus glycolipid.	Glycerophospholipids	58-74	glycolipid transfer protein	Homo sapiens	156-160
28011644-8	2017	These findings provide the first evidence for a potential phosphoglyceride headgroup-specific regulatory interaction site(s) existing on the surface of any GLTP-fold and delineate new differences between GLTP superfamily members that are specific for C1P versus glycolipid.	Glycerophospholipids	58-74	glycolipid transfer protein	Homo sapiens	204-208
28011644-8	2017	These findings provide the first evidence for a potential phosphoglyceride headgroup-specific regulatory interaction site(s) existing on the surface of any GLTP-fold and delineate new differences between GLTP superfamily members that are specific for C1P versus glycolipid.	Glycolipids	262-272	glycolipid transfer protein	Homo sapiens	156-160
28011644-8	2017	These findings provide the first evidence for a potential phosphoglyceride headgroup-specific regulatory interaction site(s) existing on the surface of any GLTP-fold and delineate new differences between GLTP superfamily members that are specific for C1P versus glycolipid.	Glycolipids	262-272	glycolipid transfer protein	Homo sapiens	204-208
27412675-8	2016	GLTP showed marked, ATP-dependent enhancement of cell-free intact microsomal LacCer synthesis from endogenous or exogenous liposomal GlcCer, supporting a role in the transport/membrane translocation of cytosolic and extra-Golgi GlcCer.	Adenosine Triphosphate	20-23	glycolipid transfer protein	Homo sapiens	0-4
24824606-1	2014	The glycolipid transfer protein (GLTP) catalyzes the binding and transport of glycolipids, but not phospholipids or neutral lipids.	Glycolipids	78-89	glycolipid transfer protein	Homo sapiens	33-37
26234207-1	2016	Structurally the glycolipid transfer protein (GLTP) fold differs from other proteins that recognize glycolipids, such as non-specific lipid transfer proteins and lysosomal lipid degradation assisting proteins, even though they act on the same class of lipids.	Glycolipids	100-111	glycolipid transfer protein	Homo sapiens	17-44
26234207-1	2016	Structurally the glycolipid transfer protein (GLTP) fold differs from other proteins that recognize glycolipids, such as non-specific lipid transfer proteins and lysosomal lipid degradation assisting proteins, even though they act on the same class of lipids.	Glycolipids	100-111	glycolipid transfer protein	Homo sapiens	46-50
25797198-0	2015	Sphingolipid transfer proteins defined by the GLTP-fold.	Sphingolipids	0-12	glycolipid transfer protein	Homo sapiens	46-50
25797198-5	2015	Human GLTP-motifs have evolved to function not only as glucosylceramide binding/transferring domains for phosphoinositol 4-phosphate adaptor protein-2 during glycosphingolipid biosynthesis but also as selective binding/transfer proteins for ceramide-1-phosphate.	Glucosylceramides	55-71	glycolipid transfer protein	Homo sapiens	6-10
25797198-5	2015	Human GLTP-motifs have evolved to function not only as glucosylceramide binding/transferring domains for phosphoinositol 4-phosphate adaptor protein-2 during glycosphingolipid biosynthesis but also as selective binding/transfer proteins for ceramide-1-phosphate.	phosphoinositol 4-phosphate	105-132	glycolipid transfer protein	Homo sapiens	6-10
25797198-5	2015	Human GLTP-motifs have evolved to function not only as glucosylceramide binding/transferring domains for phosphoinositol 4-phosphate adaptor protein-2 during glycosphingolipid biosynthesis but also as selective binding/transfer proteins for ceramide-1-phosphate.	Glycosphingolipids	158-175	glycolipid transfer protein	Homo sapiens	6-10
25797198-5	2015	Human GLTP-motifs have evolved to function not only as glucosylceramide binding/transferring domains for phosphoinositol 4-phosphate adaptor protein-2 during glycosphingolipid biosynthesis but also as selective binding/transfer proteins for ceramide-1-phosphate.	ceramide 1-phosphate	241-261	glycolipid transfer protein	Homo sapiens	6-10
25797198-6	2015	The latter, known as ceramide-1-phosphate transfer protein, recently has been shown to form GLTP-fold while critically regulating Group-IV cytoplasmic phospholipase A2 activity and pro-inflammatory eicosanoid production.	Eicosanoids	198-208	glycolipid transfer protein	Homo sapiens	92-96
25434996-4	2015	Synteny analysis confirms that TRPV4 has coevolved with two enzymes involved in sterol biosynthesis, namely MVK and GLTP.	Sterols	80-86	glycolipid transfer protein	Homo sapiens	116-120
24824606-1	2014	The glycolipid transfer protein (GLTP) catalyzes the binding and transport of glycolipids, but not phospholipids or neutral lipids.	Phospholipids	99-112	glycolipid transfer protein	Homo sapiens	33-37
24824606-6	2014	We identified eight different lipid classes that changed as a result of the GLTP down- or up-regulation treatments; glucosylceramide, lactosylceramide, globotriaosylceramide, ceramide, sphingomyelin, cholesterol-esters, diacylglycerol and phosphatidylserine.	Cholesterol Esters	200-218	glycolipid transfer protein	Homo sapiens	76-80
24824606-6	2014	We identified eight different lipid classes that changed as a result of the GLTP down- or up-regulation treatments; glucosylceramide, lactosylceramide, globotriaosylceramide, ceramide, sphingomyelin, cholesterol-esters, diacylglycerol and phosphatidylserine.	Diglycerides	220-234	glycolipid transfer protein	Homo sapiens	76-80
24824606-6	2014	We identified eight different lipid classes that changed as a result of the GLTP down- or up-regulation treatments; glucosylceramide, lactosylceramide, globotriaosylceramide, ceramide, sphingomyelin, cholesterol-esters, diacylglycerol and phosphatidylserine.	Phosphatidylserines	239-257	glycolipid transfer protein	Homo sapiens	76-80
24824606-8	2014	Further, an up-regulation of GLTP caused a substantial increase in both the Gb3 and glucosylceramide levels compared to the controls.	Glucosylceramides	84-100	glycolipid transfer protein	Homo sapiens	29-33
24824606-11	2014	The cholesterol-esters and diacylglycerol masses increased in cells that had upregulated GLTP protein levels, wheras down-regulation did not affect their amounts.	Cholesterol Esters	4-22	glycolipid transfer protein	Homo sapiens	89-93
24824606-11	2014	The cholesterol-esters and diacylglycerol masses increased in cells that had upregulated GLTP protein levels, wheras down-regulation did not affect their amounts.	Diglycerides	27-41	glycolipid transfer protein	Homo sapiens	89-93
24824606-12	2014	For the glycerophospholipids, phosphatidylserine was the only species that was lower in GLTP overexpressing cells.	Glycerophospholipids	8-28	glycolipid transfer protein	Homo sapiens	88-92
24824606-12	2014	For the glycerophospholipids, phosphatidylserine was the only species that was lower in GLTP overexpressing cells.	Phosphatidylserines	30-48	glycolipid transfer protein	Homo sapiens	88-92
24824606-17	2014	We suggest, that GLTP not only could be a significant player in cellular sphingolipid metabolism, but also could have a much broader role in the overall lipid metabolism.	Sphingolipids	73-85	glycolipid transfer protein	Homo sapiens	17-21
23519669-1	2013	Human glycolipid transfer protein (hsGLTP) forms the prototypical GLTP fold and is characterized by a broad transfer selectivity for glycosphingolipids (GSLs).	Glycosphingolipids	133-151	glycolipid transfer protein	Homo sapiens	37-41
23727546-8	2013	We then review our data on the contribution of calcium to gLTP as an approach to elucidate the mechanisms of gLTP.	Calcium	47-54	glycolipid transfer protein	Homo sapiens	58-62
23727546-8	2013	We then review our data on the contribution of calcium to gLTP as an approach to elucidate the mechanisms of gLTP.	Calcium	47-54	glycolipid transfer protein	Homo sapiens	109-113
23727546-9	2013	Data on the contribution of calcium to gLTP and on prolonged high-frequency stimulus-dependent fading of LTP have led us to support the trans-synaptic process as responsible for gLTP.	Calcium	28-35	glycolipid transfer protein	Homo sapiens	178-182
23519669-1	2013	Human glycolipid transfer protein (hsGLTP) forms the prototypical GLTP fold and is characterized by a broad transfer selectivity for glycosphingolipids (GSLs).	Glycosphingolipids	153-157	glycolipid transfer protein	Homo sapiens	37-41
23519669-2	2013	The GLTP mutation D48V near the `portal entrance" of the glycolipid binding site has recently been shown to enhance selectivity for sulfatides (SFs) containing a long acyl chain.	Glycolipids	57-67	glycolipid transfer protein	Homo sapiens	4-8
23519669-2	2013	The GLTP mutation D48V near the `portal entrance" of the glycolipid binding site has recently been shown to enhance selectivity for sulfatides (SFs) containing a long acyl chain.	Sulfoglycosphingolipids	132-142	glycolipid transfer protein	Homo sapiens	4-8
23519669-2	2013	The GLTP mutation D48V near the `portal entrance" of the glycolipid binding site has recently been shown to enhance selectivity for sulfatides (SFs) containing a long acyl chain.	SFS	144-147	glycolipid transfer protein	Homo sapiens	4-8
23369752-0	2013	GLTP-fold interaction with planar phosphatidylcholine surfaces is synergistically stimulated by phosphatidic acid and phosphatidylethanolamine.	Phosphatidylcholines	34-53	glycolipid transfer protein	Homo sapiens	0-4
23369752-0	2013	GLTP-fold interaction with planar phosphatidylcholine surfaces is synergistically stimulated by phosphatidic acid and phosphatidylethanolamine.	Phosphatidic Acids	96-113	glycolipid transfer protein	Homo sapiens	0-4
23369752-5	2013	In contrast, 1-palmitoyl-2-oleoyl-phosphatidylethanolamine (POPE) matrices supported robust BODIPY-glycolipid uptake by GLTP at both high and low surface pressures.	bodipy-glycolipid	92-109	glycolipid transfer protein	Homo sapiens	120-124
23369752-0	2013	GLTP-fold interaction with planar phosphatidylcholine surfaces is synergistically stimulated by phosphatidic acid and phosphatidylethanolamine.	phosphatidylethanolamine	118-142	glycolipid transfer protein	Homo sapiens	0-4
23369752-6	2013	Unexpectedly, negatively-charged cytosol-facing lipids, i.e., phosphatidic acid and phosphatidylserine, also supported BODIPY-glycolipid uptake by GLTP at high surface pressure.	Phosphatidic Acids	62-79	glycolipid transfer protein	Homo sapiens	147-151
23369752-1	2013	Among amphitropic proteins, human glycolipid transfer protein (GLTP) forms a structurally-unique fold that translocates on/off membranes to specifically transfer glycolipids.	Glycolipids	162-173	glycolipid transfer protein	Homo sapiens	34-61
23369752-1	2013	Among amphitropic proteins, human glycolipid transfer protein (GLTP) forms a structurally-unique fold that translocates on/off membranes to specifically transfer glycolipids.	Glycolipids	162-173	glycolipid transfer protein	Homo sapiens	63-67
23369752-6	2013	Unexpectedly, negatively-charged cytosol-facing lipids, i.e., phosphatidic acid and phosphatidylserine, also supported BODIPY-glycolipid uptake by GLTP at high surface pressure.	Phosphatidylserines	84-102	glycolipid transfer protein	Homo sapiens	147-151
23369752-2	2013	Phosphatidylcholine (PC) bilayers with curvature-induced packing stress stimulate much faster glycolipid intervesicular transfer than nonstressed PC bilayers raising questions about planar cytosol-facing biomembranes being viable sites for GLTP interaction.	Phosphatidylcholines	0-19	glycolipid transfer protein	Homo sapiens	240-244
23369752-2	2013	Phosphatidylcholine (PC) bilayers with curvature-induced packing stress stimulate much faster glycolipid intervesicular transfer than nonstressed PC bilayers raising questions about planar cytosol-facing biomembranes being viable sites for GLTP interaction.	Phosphatidylcholines	21-23	glycolipid transfer protein	Homo sapiens	240-244
23369752-6	2013	Unexpectedly, negatively-charged cytosol-facing lipids, i.e., phosphatidic acid and phosphatidylserine, also supported BODIPY-glycolipid uptake by GLTP at high surface pressure.	4,4-difluoro-4-bora-3a,4a-diaza-s-indacene	119-125	glycolipid transfer protein	Homo sapiens	147-151
23369752-3	2013	Herein, GLTP-mediated desorption kinetics of fluorescent glycolipid (tetramethyl-boron dipyrromethene (BODIPY)-label) from lipid monolayers are assessed using a novel microfluidics-based surface balance that monitors lipid lateral packing while simultaneously acquiring surface fluorescence data.	Glycolipids	57-67	glycolipid transfer protein	Homo sapiens	8-12
23369752-6	2013	Unexpectedly, negatively-charged cytosol-facing lipids, i.e., phosphatidic acid and phosphatidylserine, also supported BODIPY-glycolipid uptake by GLTP at high surface pressure.	Glycolipids	126-136	glycolipid transfer protein	Homo sapiens	147-151
23369752-3	2013	Herein, GLTP-mediated desorption kinetics of fluorescent glycolipid (tetramethyl-boron dipyrromethene (BODIPY)-label) from lipid monolayers are assessed using a novel microfluidics-based surface balance that monitors lipid lateral packing while simultaneously acquiring surface fluorescence data.	tetramethyl-boron dipyrromethene	69-101	glycolipid transfer protein	Homo sapiens	8-12
23369752-7	2013	Remarkably, including both 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate (5 mol%) and POPE (15 mol%) in POPC synergistically activated GLTP at high surface pressure.	1-palmitoyl-2-oleoyl-glycero-3-phosphatidic acid	27-70	glycolipid transfer protein	Homo sapiens	133-137
23369752-3	2013	Herein, GLTP-mediated desorption kinetics of fluorescent glycolipid (tetramethyl-boron dipyrromethene (BODIPY)-label) from lipid monolayers are assessed using a novel microfluidics-based surface balance that monitors lipid lateral packing while simultaneously acquiring surface fluorescence data.	4,4-difluoro-4-bora-3a,4a-diaza-s-indacene	103-109	glycolipid transfer protein	Homo sapiens	8-12
23369752-4	2013	At biomembrane-like packing (30-35 mN/m), GLTP uptake of BODIPY-glycolipid from POPC monolayers was nearly nonexistent but could be induced by reducing surface pressure to mirror packing in curvature-stressed bilayers.	bodipy-glycolipid	57-74	glycolipid transfer protein	Homo sapiens	42-46
23369752-5	2013	In contrast, 1-palmitoyl-2-oleoyl-phosphatidylethanolamine (POPE) matrices supported robust BODIPY-glycolipid uptake by GLTP at both high and low surface pressures.	1-palmitoyl-2-oleoylphosphatidylethanolamine	13-58	glycolipid transfer protein	Homo sapiens	120-124
23369752-5	2013	In contrast, 1-palmitoyl-2-oleoyl-phosphatidylethanolamine (POPE) matrices supported robust BODIPY-glycolipid uptake by GLTP at both high and low surface pressures.	1-palmitoyl-2-oleoylphosphatidylethanolamine	60-64	glycolipid transfer protein	Homo sapiens	120-124
23159414-0	2013	The glycolipid transfer protein (GLTP) domain of phosphoinositol 4-phosphate adaptor protein-2 (FAPP2): structure drives preference for simple neutral glycosphingolipids.	Glycosphingolipids	151-169	glycolipid transfer protein	Homo sapiens	4-31
23159414-5	2013	A structurally-based preference for other simple uncharged GSLs, in addition to glucosylceramide, makes human FAPP2-GLTP more similar to fungal HET-C2 than to plant AtGLTP1 (glucosylceramide-specific) or to broadly GSL-selective human GLTP.	Glycosphingolipids	59-62	glycolipid transfer protein	Homo sapiens	116-120
23159414-0	2013	The glycolipid transfer protein (GLTP) domain of phosphoinositol 4-phosphate adaptor protein-2 (FAPP2): structure drives preference for simple neutral glycosphingolipids.	Glycosphingolipids	151-169	glycolipid transfer protein	Homo sapiens	33-37
23555818-0	2013	GLTP mediated non-vesicular GM1 transport between native membranes.	G(M1) Ganglioside	28-31	glycolipid transfer protein	Homo sapiens	0-4
23555818-3	2013	Using the soluble LTP glycolipid transfer protein (GLTP), we examined GM1 (monosialotetrahexosyl-ganglioside) transfer to native membrane surfaces.	G(M1) Ganglioside	70-73	glycolipid transfer protein	Homo sapiens	51-55
23555818-4	2013	With artificial GM1 donor liposomes, GLTP can be used to increase glycolipid levels over natural levels in either side of the membrane leaflet, i.e., external or cytosolic.	G(M1) Ganglioside	16-19	glycolipid transfer protein	Homo sapiens	37-41
23555818-4	2013	With artificial GM1 donor liposomes, GLTP can be used to increase glycolipid levels over natural levels in either side of the membrane leaflet, i.e., external or cytosolic.	Glycolipids	66-76	glycolipid transfer protein	Homo sapiens	37-41
23555818-5	2013	In a system with native donor- and acceptor-membranes, we find that GLTP balances highly variable GM1 concentrations in a population of membranes from one cell type, and in addition, transfers lipids between membranes from different cell types.	G(M1) Ganglioside	98-101	glycolipid transfer protein	Homo sapiens	68-72
23555818-8	2013	Furthermore, the data demonstrates the suitability of GLTP as a tool for artificially increasing glycolipid levels in cellular membranes.	Glycolipids	97-107	glycolipid transfer protein	Homo sapiens	54-58
21910967-1	2011	The glycolipid transfer protein (GLTP) is capable of transporting glycolipids from a donor membrane, through the aqueous environment, to an acceptor membrane.	Glycolipids	66-77	glycolipid transfer protein	Homo sapiens	4-31
21910967-1	2011	The glycolipid transfer protein (GLTP) is capable of transporting glycolipids from a donor membrane, through the aqueous environment, to an acceptor membrane.	Glycolipids	66-77	glycolipid transfer protein	Homo sapiens	33-37
21910967-2	2011	The GLTP mediated glycolipid transfer from sphingomyelin membranes is very slow.	Sphingomyelins	43-56	glycolipid transfer protein	Homo sapiens	4-8
21910967-5	2011	Consequently, the properties of the membrane lipids surrounding the glycolipids play an important role in the ability of GLTP to bind and transfer its substrates.	Glycolipids	68-79	glycolipid transfer protein	Homo sapiens	121-125
21910967-6	2011	Since GLTP transfer of glycolipids is almost nonexistent from sphingomyelin membranes, we have used this exceptionality to investigate if membrane intercalators can alter the membrane packing and induce glycolipid transfer.	Glycolipids	23-34	glycolipid transfer protein	Homo sapiens	6-10
21910967-6	2011	Since GLTP transfer of glycolipids is almost nonexistent from sphingomyelin membranes, we have used this exceptionality to investigate if membrane intercalators can alter the membrane packing and induce glycolipid transfer.	Glycolipids	23-33	glycolipid transfer protein	Homo sapiens	6-10
21910967-7	2011	We found that the bile salts cholate, deoxycholate, taurocholate and taurodeoxycholate, cause glucosylceramide to become transferrable by GLTP.	Bile Acids and Salts	18-28	glycolipid transfer protein	Homo sapiens	138-142
21910967-7	2011	We found that the bile salts cholate, deoxycholate, taurocholate and taurodeoxycholate, cause glucosylceramide to become transferrable by GLTP.	Cholates	29-36	glycolipid transfer protein	Homo sapiens	138-142
21910967-7	2011	We found that the bile salts cholate, deoxycholate, taurocholate and taurodeoxycholate, cause glucosylceramide to become transferrable by GLTP.	Deoxycholic Acid	38-50	glycolipid transfer protein	Homo sapiens	138-142
21910967-7	2011	We found that the bile salts cholate, deoxycholate, taurocholate and taurodeoxycholate, cause glucosylceramide to become transferrable by GLTP.	Taurocholic Acid	52-64	glycolipid transfer protein	Homo sapiens	138-142
21910967-7	2011	We found that the bile salts cholate, deoxycholate, taurocholate and taurodeoxycholate, cause glucosylceramide to become transferrable by GLTP.	Taurodeoxycholic Acid	69-86	glycolipid transfer protein	Homo sapiens	138-142
21910967-7	2011	We found that the bile salts cholate, deoxycholate, taurocholate and taurodeoxycholate, cause glucosylceramide to become transferrable by GLTP.	Glucosylceramides	94-110	glycolipid transfer protein	Homo sapiens	138-142
20974858-9	2011	Among tested sphingolipid analogs of glucosylceramide, sulfatide, ganglioside GM1, ceramide 1-phosphate, sphingosine 1-phosphate, dihydroceramide, sphingosine, only ceramide, a nonglycosylated precursor metabolite unable to bind to GLTP protein, induced GLTP promoter activity and raised transcript levels in vivo.	Sphingolipids	13-25	glycolipid transfer protein	Homo sapiens	232-236
20974858-0	2011	Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: involvement of the bioactive sphingolipid ceramide.	sphingolipid ceramide	115-136	glycolipid transfer protein	Homo sapiens	6-33
20974858-0	2011	Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: involvement of the bioactive sphingolipid ceramide.	sphingolipid ceramide	115-136	glycolipid transfer protein	Homo sapiens	40-44
20974858-3	2011	Herein, the ability of glycosphingolipids (and their sphingolipid metabolites) to regulate the transcriptional expression of GLTP via its promoter has been evaluated.	Glycosphingolipids	23-41	glycolipid transfer protein	Homo sapiens	125-129
20974858-3	2011	Herein, the ability of glycosphingolipids (and their sphingolipid metabolites) to regulate the transcriptional expression of GLTP via its promoter has been evaluated.	Sphingolipids	28-40	glycolipid transfer protein	Homo sapiens	125-129
22078563-4	2011	New crystal structures of wild-type GLTP and two mutants (D48V and A47D  D48V), each containing bound N-nervonoyl-sulfatide, reveal the molecular basis for selective anchoring of sulfatide (3-O-sulfo-galactosylceramide) by D48V-GLTP.	n-nervonoyl-sulfatide	102-123	glycolipid transfer protein	Homo sapiens	36-40
22078563-4	2011	New crystal structures of wild-type GLTP and two mutants (D48V and A47D  D48V), each containing bound N-nervonoyl-sulfatide, reveal the molecular basis for selective anchoring of sulfatide (3-O-sulfo-galactosylceramide) by D48V-GLTP.	n-nervonoyl-sulfatide	102-123	glycolipid transfer protein	Homo sapiens	228-232
22078563-4	2011	New crystal structures of wild-type GLTP and two mutants (D48V and A47D  D48V), each containing bound N-nervonoyl-sulfatide, reveal the molecular basis for selective anchoring of sulfatide (3-O-sulfo-galactosylceramide) by D48V-GLTP.	Sulfoglycosphingolipids	114-123	glycolipid transfer protein	Homo sapiens	36-40
22078563-4	2011	New crystal structures of wild-type GLTP and two mutants (D48V and A47D  D48V), each containing bound N-nervonoyl-sulfatide, reveal the molecular basis for selective anchoring of sulfatide (3-O-sulfo-galactosylceramide) by D48V-GLTP.	3-o-sulfo-galactosylceramide	190-218	glycolipid transfer protein	Homo sapiens	36-40
22078563-6	2011	"Door-opening" conformational changes by phenylalanines within the hydrophobic pocket are revealed during lipid encapsulation by new crystal structures of bona fide apo-GLTP and GLTP complexed with N-oleoyl-glucosylceramide.	Phenylalanine	41-55	glycolipid transfer protein	Homo sapiens	169-173
22078563-6	2011	"Door-opening" conformational changes by phenylalanines within the hydrophobic pocket are revealed during lipid encapsulation by new crystal structures of bona fide apo-GLTP and GLTP complexed with N-oleoyl-glucosylceramide.	Phenylalanine	41-55	glycolipid transfer protein	Homo sapiens	178-182
22078563-6	2011	"Door-opening" conformational changes by phenylalanines within the hydrophobic pocket are revealed during lipid encapsulation by new crystal structures of bona fide apo-GLTP and GLTP complexed with N-oleoyl-glucosylceramide.	n-oleoyl-glucosylceramide	198-223	glycolipid transfer protein	Homo sapiens	169-173
22078563-6	2011	"Door-opening" conformational changes by phenylalanines within the hydrophobic pocket are revealed during lipid encapsulation by new crystal structures of bona fide apo-GLTP and GLTP complexed with N-oleoyl-glucosylceramide.	n-oleoyl-glucosylceramide	198-223	glycolipid transfer protein	Homo sapiens	178-182
21553912-4	2011	To gain such insights into the disulfide-less GLTP fold, we investigated the effect of a change in pH on the fungal HET-C2 GLTP fold by taking advantage of its two tryptophans and four tyrosines (compared to three tryptophans and 10 tyrosines in human GLTP).	Disulfides	31-40	glycolipid transfer protein	Homo sapiens	46-50
21553912-4	2011	To gain such insights into the disulfide-less GLTP fold, we investigated the effect of a change in pH on the fungal HET-C2 GLTP fold by taking advantage of its two tryptophans and four tyrosines (compared to three tryptophans and 10 tyrosines in human GLTP).	Disulfides	31-40	glycolipid transfer protein	Homo sapiens	123-127
21553912-4	2011	To gain such insights into the disulfide-less GLTP fold, we investigated the effect of a change in pH on the fungal HET-C2 GLTP fold by taking advantage of its two tryptophans and four tyrosines (compared to three tryptophans and 10 tyrosines in human GLTP).	Disulfides	31-40	glycolipid transfer protein	Homo sapiens	123-127
20974858-8	2011	Sp1/Sp3 RNA silencing and mithramycin A treatment significantly inhibited GLTP promoter activity.	mithramycin A	26-39	glycolipid transfer protein	Homo sapiens	74-78
20974858-9	2011	Among tested sphingolipid analogs of glucosylceramide, sulfatide, ganglioside GM1, ceramide 1-phosphate, sphingosine 1-phosphate, dihydroceramide, sphingosine, only ceramide, a nonglycosylated precursor metabolite unable to bind to GLTP protein, induced GLTP promoter activity and raised transcript levels in vivo.	Sphingolipids	13-25	glycolipid transfer protein	Homo sapiens	254-258
20974858-11	2011	Ceramide treatment also altered the in vivo binding affinity of Sp1 and Sp3 for the GLTP promoter and decreased Sp3 acetylation.	Ceramides	0-8	glycolipid transfer protein	Homo sapiens	84-88
20974858-12	2011	This study represents the first characterization of any Gltp gene promoter and links human GLTP expression to sphingolipid homeostasis through ceramide.	Sphingolipids	110-122	glycolipid transfer protein	Homo sapiens	56-60
20974858-12	2011	This study represents the first characterization of any Gltp gene promoter and links human GLTP expression to sphingolipid homeostasis through ceramide.	Sphingolipids	110-122	glycolipid transfer protein	Homo sapiens	91-95
20974858-12	2011	This study represents the first characterization of any Gltp gene promoter and links human GLTP expression to sphingolipid homeostasis through ceramide.	Ceramides	143-151	glycolipid transfer protein	Homo sapiens	56-60
20974858-12	2011	This study represents the first characterization of any Gltp gene promoter and links human GLTP expression to sphingolipid homeostasis through ceramide.	Ceramides	143-151	glycolipid transfer protein	Homo sapiens	91-95
18657186-3	2008	Surprisingly, a GLTP mutant form impaired in glycolipid transfer activity also complemented the acd11 mutants.	Glycolipids	45-55	glycolipid transfer protein	Homo sapiens	16-20
21044592-0	2010	Dynamic modulation of the glycosphingolipid content in supported lipid bilayers by glycolipid transfer protein.	Glycosphingolipids	26-43	glycolipid transfer protein	Homo sapiens	83-110
21044592-3	2010	Glycolipid transfer protein (GLTP) can selectively transfer GSLs between membrane compartments.	Glycosphingolipids	60-64	glycolipid transfer protein	Homo sapiens	0-27
21044592-3	2010	Glycolipid transfer protein (GLTP) can selectively transfer GSLs between membrane compartments.	Glycosphingolipids	60-64	glycolipid transfer protein	Homo sapiens	29-33
21044592-4	2010	Using the ganglioside GM1 as a model GSL, and two mass-sensitive and label-free characterization techniques-quartz crystal microbalance with dissipation monitoring and ellipsometry-we demonstrate that GLTP is an efficient and robust biochemical tool to dynamically modulate the GSL content of SLBs up to 10 mol % GM1, and to quantitatively control the GSL content in the bulk-facing SLB leaflet.	Gangliosides	10-21	glycolipid transfer protein	Homo sapiens	201-205
21044592-4	2010	Using the ganglioside GM1 as a model GSL, and two mass-sensitive and label-free characterization techniques-quartz crystal microbalance with dissipation monitoring and ellipsometry-we demonstrate that GLTP is an efficient and robust biochemical tool to dynamically modulate the GSL content of SLBs up to 10 mol % GM1, and to quantitatively control the GSL content in the bulk-facing SLB leaflet.	G(M1) Ganglioside	22-25	glycolipid transfer protein	Homo sapiens	201-205
21044592-4	2010	Using the ganglioside GM1 as a model GSL, and two mass-sensitive and label-free characterization techniques-quartz crystal microbalance with dissipation monitoring and ellipsometry-we demonstrate that GLTP is an efficient and robust biochemical tool to dynamically modulate the GSL content of SLBs up to 10 mol % GM1, and to quantitatively control the GSL content in the bulk-facing SLB leaflet.	slbs	293-297	glycolipid transfer protein	Homo sapiens	201-205
21044592-4	2010	Using the ganglioside GM1 as a model GSL, and two mass-sensitive and label-free characterization techniques-quartz crystal microbalance with dissipation monitoring and ellipsometry-we demonstrate that GLTP is an efficient and robust biochemical tool to dynamically modulate the GSL content of SLBs up to 10 mol % GM1, and to quantitatively control the GSL content in the bulk-facing SLB leaflet.	G(M1) Ganglioside	313-316	glycolipid transfer protein	Homo sapiens	201-205
21044592-7	2010	Furthermore, we quantify the liganding affinity of GLTP for GM1 in an SLB context to be 1.5 muM.	G(M1) Ganglioside	60-63	glycolipid transfer protein	Homo sapiens	51-55
20164530-0	2010	Structural determination and tryptophan fluorescence of heterokaryon incompatibility C2 protein (HET-C2), a fungal glycolipid transfer protein (GLTP), provide novel insights into glycolipid specificity and membrane interaction by the GLTP fold.	Tryptophan	29-39	glycolipid transfer protein	Homo sapiens	115-142
20164530-0	2010	Structural determination and tryptophan fluorescence of heterokaryon incompatibility C2 protein (HET-C2), a fungal glycolipid transfer protein (GLTP), provide novel insights into glycolipid specificity and membrane interaction by the GLTP fold.	Tryptophan	29-39	glycolipid transfer protein	Homo sapiens	144-148
20164530-0	2010	Structural determination and tryptophan fluorescence of heterokaryon incompatibility C2 protein (HET-C2), a fungal glycolipid transfer protein (GLTP), provide novel insights into glycolipid specificity and membrane interaction by the GLTP fold.	Glycolipids	115-125	glycolipid transfer protein	Homo sapiens	144-148
20164530-0	2010	Structural determination and tryptophan fluorescence of heterokaryon incompatibility C2 protein (HET-C2), a fungal glycolipid transfer protein (GLTP), provide novel insights into glycolipid specificity and membrane interaction by the GLTP fold.	Glycolipids	115-125	glycolipid transfer protein	Homo sapiens	234-238
20164530-4	2010	X-ray diffraction (1.9 A) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp(66), Asn(70), Lys(73), Trp(109), and His(147)) conserved and properly oriented for glycolipid binding.	Sugars	60-65	glycolipid transfer protein	Homo sapiens	37-41
20164530-4	2010	X-ray diffraction (1.9 A) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp(66), Asn(70), Lys(73), Trp(109), and His(147)) conserved and properly oriented for glycolipid binding.	Aspartic Acid	98-101	glycolipid transfer protein	Homo sapiens	37-41
20164530-4	2010	X-ray diffraction (1.9 A) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp(66), Asn(70), Lys(73), Trp(109), and His(147)) conserved and properly oriented for glycolipid binding.	Asparagine	107-110	glycolipid transfer protein	Homo sapiens	37-41
20164530-4	2010	X-ray diffraction (1.9 A) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp(66), Asn(70), Lys(73), Trp(109), and His(147)) conserved and properly oriented for glycolipid binding.	Lysine	116-119	glycolipid transfer protein	Homo sapiens	37-41
20164530-4	2010	X-ray diffraction (1.9 A) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp(66), Asn(70), Lys(73), Trp(109), and His(147)) conserved and properly oriented for glycolipid binding.	Tryptophan	125-128	glycolipid transfer protein	Homo sapiens	37-41
20164530-4	2010	X-ray diffraction (1.9 A) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp(66), Asn(70), Lys(73), Trp(109), and His(147)) conserved and properly oriented for glycolipid binding.	Histidine	139-142	glycolipid transfer protein	Homo sapiens	37-41
20164530-4	2010	X-ray diffraction (1.9 A) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp(66), Asn(70), Lys(73), Trp(109), and His(147)) conserved and properly oriented for glycolipid binding.	Glycolipids	185-195	glycolipid transfer protein	Homo sapiens	37-41
20164530-5	2010	Far-UV CD showed secondary structure dominated by alpha-helices and a cooperative thermal unfolding transition of 49 degrees C, features consistent with a GLTP fold.	Cadmium	7-9	glycolipid transfer protein	Homo sapiens	155-159
20804726-1	2011	The glycolipid transfer protein (GLTP) is a protein capable of binding and transferring glycolipids.	Glycolipids	88-99	glycolipid transfer protein	Homo sapiens	4-31
20804726-1	2011	The glycolipid transfer protein (GLTP) is a protein capable of binding and transferring glycolipids.	Glycolipids	88-99	glycolipid transfer protein	Homo sapiens	33-37
20804726-2	2011	GLTP is cytosolic and it can interact through its FFAT-like (two phenylalanines in an acidic tract) motif with proteins localized on the surface of the endoplasmic reticulum.	Phenylalanine	65-79	glycolipid transfer protein	Homo sapiens	0-4
20804726-3	2011	Previous in vitro work with GLTP has focused mainly on the complete transfer reaction of the protein, that is, binding and subsequent removal of the glycolipid from the donor membrane, transfer through the aqueous environment, and the final release of the glycolipid to an acceptor membrane.	Glycolipids	149-159	glycolipid transfer protein	Homo sapiens	28-32
20804726-3	2011	Previous in vitro work with GLTP has focused mainly on the complete transfer reaction of the protein, that is, binding and subsequent removal of the glycolipid from the donor membrane, transfer through the aqueous environment, and the final release of the glycolipid to an acceptor membrane.	Glycolipids	256-266	glycolipid transfer protein	Homo sapiens	28-32
20804726-6	2011	We used the new approach for detailed structure-function studies of GLTP by examining the glycolipid transfer capacity of specific GLTP tryptophan mutants.	Glycolipids	90-100	glycolipid transfer protein	Homo sapiens	68-72
20804726-6	2011	We used the new approach for detailed structure-function studies of GLTP by examining the glycolipid transfer capacity of specific GLTP tryptophan mutants.	Glycolipids	90-100	glycolipid transfer protein	Homo sapiens	131-135
20804726-6	2011	We used the new approach for detailed structure-function studies of GLTP by examining the glycolipid transfer capacity of specific GLTP tryptophan mutants.	Tryptophan	136-146	glycolipid transfer protein	Homo sapiens	68-72
20804726-6	2011	We used the new approach for detailed structure-function studies of GLTP by examining the glycolipid transfer capacity of specific GLTP tryptophan mutants.	Tryptophan	136-146	glycolipid transfer protein	Homo sapiens	131-135
21625605-1	2011	Glycolipid transfer protein (GLTP) accelerates glycosphingolipid (GSL) intermembrane transfer via a unique lipid transfer/binding fold (GLTP-fold) that defines the GLTP superfamily and is the prototype for GLTP-like domains in larger proteins, i.e. phosphoinositol 4-phosphate adaptor protein-2 (FAPP2).	Glycosphingolipids	47-64	glycolipid transfer protein	Homo sapiens	0-27
21625605-1	2011	Glycolipid transfer protein (GLTP) accelerates glycosphingolipid (GSL) intermembrane transfer via a unique lipid transfer/binding fold (GLTP-fold) that defines the GLTP superfamily and is the prototype for GLTP-like domains in larger proteins, i.e. phosphoinositol 4-phosphate adaptor protein-2 (FAPP2).	Glycosphingolipids	47-64	glycolipid transfer protein	Homo sapiens	29-33
21625605-1	2011	Glycolipid transfer protein (GLTP) accelerates glycosphingolipid (GSL) intermembrane transfer via a unique lipid transfer/binding fold (GLTP-fold) that defines the GLTP superfamily and is the prototype for GLTP-like domains in larger proteins, i.e. phosphoinositol 4-phosphate adaptor protein-2 (FAPP2).	Glycosphingolipids	47-64	glycolipid transfer protein	Homo sapiens	136-140
21625605-1	2011	Glycolipid transfer protein (GLTP) accelerates glycosphingolipid (GSL) intermembrane transfer via a unique lipid transfer/binding fold (GLTP-fold) that defines the GLTP superfamily and is the prototype for GLTP-like domains in larger proteins, i.e. phosphoinositol 4-phosphate adaptor protein-2 (FAPP2).	Glycosphingolipids	47-64	glycolipid transfer protein	Homo sapiens	136-140
21625605-1	2011	Glycolipid transfer protein (GLTP) accelerates glycosphingolipid (GSL) intermembrane transfer via a unique lipid transfer/binding fold (GLTP-fold) that defines the GLTP superfamily and is the prototype for GLTP-like domains in larger proteins, i.e. phosphoinositol 4-phosphate adaptor protein-2 (FAPP2).	Glycosphingolipids	47-64	glycolipid transfer protein	Homo sapiens	136-140
21625605-1	2011	Glycolipid transfer protein (GLTP) accelerates glycosphingolipid (GSL) intermembrane transfer via a unique lipid transfer/binding fold (GLTP-fold) that defines the GLTP superfamily and is the prototype for GLTP-like domains in larger proteins, i.e. phosphoinositol 4-phosphate adaptor protein-2 (FAPP2).	phosphoinositol 4-phosphate	249-276	glycolipid transfer protein	Homo sapiens	0-27
21625605-1	2011	Glycolipid transfer protein (GLTP) accelerates glycosphingolipid (GSL) intermembrane transfer via a unique lipid transfer/binding fold (GLTP-fold) that defines the GLTP superfamily and is the prototype for GLTP-like domains in larger proteins, i.e. phosphoinositol 4-phosphate adaptor protein-2 (FAPP2).	phosphoinositol 4-phosphate	249-276	glycolipid transfer protein	Homo sapiens	29-33
21625605-1	2011	Glycolipid transfer protein (GLTP) accelerates glycosphingolipid (GSL) intermembrane transfer via a unique lipid transfer/binding fold (GLTP-fold) that defines the GLTP superfamily and is the prototype for GLTP-like domains in larger proteins, i.e. phosphoinositol 4-phosphate adaptor protein-2 (FAPP2).	phosphoinositol 4-phosphate	249-276	glycolipid transfer protein	Homo sapiens	136-140
21625605-1	2011	Glycolipid transfer protein (GLTP) accelerates glycosphingolipid (GSL) intermembrane transfer via a unique lipid transfer/binding fold (GLTP-fold) that defines the GLTP superfamily and is the prototype for GLTP-like domains in larger proteins, i.e. phosphoinositol 4-phosphate adaptor protein-2 (FAPP2).	phosphoinositol 4-phosphate	249-276	glycolipid transfer protein	Homo sapiens	136-140
21625605-1	2011	Glycolipid transfer protein (GLTP) accelerates glycosphingolipid (GSL) intermembrane transfer via a unique lipid transfer/binding fold (GLTP-fold) that defines the GLTP superfamily and is the prototype for GLTP-like domains in larger proteins, i.e. phosphoinositol 4-phosphate adaptor protein-2 (FAPP2).	phosphoinositol 4-phosphate	249-276	glycolipid transfer protein	Homo sapiens	136-140
21625605-2	2011	Although GLTP-folds are known to play roles in the nonvesicular intracellular trafficking of glycolipids, their ability to alter cell phenotype remains unexplored.	Glycolipids	93-104	glycolipid transfer protein	Homo sapiens	9-13
21625605-5	2011	In contrast, overexpression of W96A-GLTP, a liganding-site point mutant with abrogated ability to transfer glycolipid, did not alter cell shape.	Glycolipids	107-117	glycolipid transfer protein	Homo sapiens	31-40
20959104-0	2010	Human GLTP: Three distinct functions for the three tryptophans in a novel peripheral amphitropic fold.	Tryptophan	51-62	glycolipid transfer protein	Homo sapiens	6-10
20959104-4	2010	Far-ultraviolet and near-ultraviolet circular dichroism spectroscopic analyses showed that W96F-W142Y-GLTP and W96Y-GLTP retain their native conformation and stability, whereas W85Y-W96F-GLTP is slightly altered, in agreement with relative glycolipid transfer activities of >90%, ~85%, and ~45%, respectively.	Glycolipids	240-250	glycolipid transfer protein	Homo sapiens	102-106
20959104-4	2010	Far-ultraviolet and near-ultraviolet circular dichroism spectroscopic analyses showed that W96F-W142Y-GLTP and W96Y-GLTP retain their native conformation and stability, whereas W85Y-W96F-GLTP is slightly altered, in agreement with relative glycolipid transfer activities of >90%, ~85%, and ~45%, respectively.	Glycolipids	240-250	glycolipid transfer protein	Homo sapiens	101-106
20959104-8	2010	The findings illustrate remarkable versatility for Trp, providing three distinct intramolecular functions in the novel amphitropic GLTP fold.	Tryptophan	51-54	glycolipid transfer protein	Homo sapiens	131-135
19665998-1	2009	The glycolipid transfer protein (GLTP) is a cytoplasmic protein with an ability to bind glycolipids and catalyze their in vitro transfer.	Glycolipids	88-99	glycolipid transfer protein	Homo sapiens	33-37
19665998-4	2009	Here we used glutathione S-transferase pull-down experiments to confirm that GLTP and VAP-A interact.	Glutathione	13-24	glycolipid transfer protein	Homo sapiens	77-81
19270338-3	2009	In the present study, changes in human GLTP tryptophan fluorescence, induced by membrane vesicles containing glycolipid, are shown to reflect glycolipid binding when vesicle concentrations are low.	Tryptophan	44-54	glycolipid transfer protein	Homo sapiens	39-43
19270338-3	2009	In the present study, changes in human GLTP tryptophan fluorescence, induced by membrane vesicles containing glycolipid, are shown to reflect glycolipid binding when vesicle concentrations are low.	Glycolipids	109-119	glycolipid transfer protein	Homo sapiens	39-43
19270338-3	2009	In the present study, changes in human GLTP tryptophan fluorescence, induced by membrane vesicles containing glycolipid, are shown to reflect glycolipid binding when vesicle concentrations are low.	Glycolipids	142-152	glycolipid transfer protein	Homo sapiens	39-43
19270338-6	2009	Instead, glycolipid binding alters the local environment of Trp-96, which accounts for approximately 70% of total emission intensity of three Trp residues in GLTP and provides a stacking platform that aids formation of a hydrogen bond network with the ceramide-linked sugar of the glycolipid headgroup.	Glycolipids	9-19	glycolipid transfer protein	Homo sapiens	158-162
19270338-6	2009	Instead, glycolipid binding alters the local environment of Trp-96, which accounts for approximately 70% of total emission intensity of three Trp residues in GLTP and provides a stacking platform that aids formation of a hydrogen bond network with the ceramide-linked sugar of the glycolipid headgroup.	Tryptophan	60-63	glycolipid transfer protein	Homo sapiens	158-162
19270338-6	2009	Instead, glycolipid binding alters the local environment of Trp-96, which accounts for approximately 70% of total emission intensity of three Trp residues in GLTP and provides a stacking platform that aids formation of a hydrogen bond network with the ceramide-linked sugar of the glycolipid headgroup.	Tryptophan	142-145	glycolipid transfer protein	Homo sapiens	158-162
19270338-6	2009	Instead, glycolipid binding alters the local environment of Trp-96, which accounts for approximately 70% of total emission intensity of three Trp residues in GLTP and provides a stacking platform that aids formation of a hydrogen bond network with the ceramide-linked sugar of the glycolipid headgroup.	Sugars	268-273	glycolipid transfer protein	Homo sapiens	158-162
19270338-7	2009	The changes in Trp signal were used to quantitatively assess human GLTP binding affinity for various lipids including glycolipids containing different sugar headgroups and homogenous acyl chains.	Tryptophan	15-18	glycolipid transfer protein	Homo sapiens	67-71
19270338-7	2009	The changes in Trp signal were used to quantitatively assess human GLTP binding affinity for various lipids including glycolipids containing different sugar headgroups and homogenous acyl chains.	Glycolipids	118-129	glycolipid transfer protein	Homo sapiens	67-71
19270338-7	2009	The changes in Trp signal were used to quantitatively assess human GLTP binding affinity for various lipids including glycolipids containing different sugar headgroups and homogenous acyl chains.	Sugars	151-156	glycolipid transfer protein	Homo sapiens	67-71
18537822-1	2008	Arabidopsis thaliana At2g33470 encodes a glycolipid transfer protein (GLTP) that enhances the intervesicular trafficking of glycosphingolipids in vitro.	Glycosphingolipids	124-142	glycolipid transfer protein	Homo sapiens	41-68
18537822-1	2008	Arabidopsis thaliana At2g33470 encodes a glycolipid transfer protein (GLTP) that enhances the intervesicular trafficking of glycosphingolipids in vitro.	Glycosphingolipids	124-142	glycolipid transfer protein	Homo sapiens	70-74
18537822-6	2008	The human GLTP transfers BODIPY-glucosylceramide, BODIPY-galactosylceramide and BODIPY-lactosylceramide with rates greater than 0.8 pmol.s(-1).	bodipy-glucosylceramide	25-48	glycolipid transfer protein	Homo sapiens	10-14
18537822-6	2008	The human GLTP transfers BODIPY-glucosylceramide, BODIPY-galactosylceramide and BODIPY-lactosylceramide with rates greater than 0.8 pmol.s(-1).	bodipy-galactosylceramide	50-75	glycolipid transfer protein	Homo sapiens	10-14
18537822-6	2008	The human GLTP transfers BODIPY-glucosylceramide, BODIPY-galactosylceramide and BODIPY-lactosylceramide with rates greater than 0.8 pmol.s(-1).	BODIPY lactosylceramide	80-103	glycolipid transfer protein	Homo sapiens	10-14
18537822-7	2008	Structural models showed that the residues that are most critical for glycosphingolipid binding in human GLTP are conserved in AtGLTP1, but some of the sugar-binding residues are unique, and this provides an explanation for the distinctly different transfer preferences of AtGLTP1 and human GLTP.	Glycosphingolipids	70-87	glycolipid transfer protein	Homo sapiens	105-109
16777057-2	2006	GLTP can catalyze the transfer of a fluorescently labeled GSL, anthrylvinyl-galactosylceramide (AV-GalCer), from vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and dipalmitoylphosphatidylcholine matrices, but not from vesicles prepared from N-palmitoylsphingomyelin, regardless of the cholesterol content of the vesicles.	palmitoylsphingomyelin	264-288	glycolipid transfer protein	Homo sapiens	0-4
17980653-6	2007	We have also used a fluorescence resonance energy transfer assay to detect transfer of fluorescently labeled BODIPY-glucosylceramide in the cytosolic fraction from both wild-type and GLTP-overexpressing HeLa cells.	bodipy-glucosylceramide	109-132	glycolipid transfer protein	Homo sapiens	183-187
17980653-7	2007	Furthermore, we have studied de novo sphingolipid changes in cells overexpressing GLTP using sphinganine metabolic labeling.	Sphingolipids	37-49	glycolipid transfer protein	Homo sapiens	82-86
17980653-7	2007	Furthermore, we have studied de novo sphingolipid changes in cells overexpressing GLTP using sphinganine metabolic labeling.	safingol	93-104	glycolipid transfer protein	Homo sapiens	82-86
17980653-10	2007	We propose that GLTP is not likely involved in the de novo synthesis of glycosphingolipids, but could rather have a role as a glycolipid sensor for the cellular levels of glucosylceramide.	Glycosphingolipids	72-90	glycolipid transfer protein	Homo sapiens	16-20
17980653-10	2007	We propose that GLTP is not likely involved in the de novo synthesis of glycosphingolipids, but could rather have a role as a glycolipid sensor for the cellular levels of glucosylceramide.	Glycolipids	126-136	glycolipid transfer protein	Homo sapiens	16-20
17980653-10	2007	We propose that GLTP is not likely involved in the de novo synthesis of glycosphingolipids, but could rather have a role as a glycolipid sensor for the cellular levels of glucosylceramide.	Glucosylceramides	171-187	glycolipid transfer protein	Homo sapiens	16-20
16908009-1	2006	In this study we have addressed the ability of the glycolipid transfer protein (GLTP) to transfer anthrylvinyl-galactosylceramide at different pH and sodium chloride concentrations, and the ability of three different mutants to transfer the fluorescently labeled galactosylceramide between donor and acceptor model membranes.	anthrylvinyl-galactosylceramide	98-129	glycolipid transfer protein	Homo sapiens	80-84
16908009-1	2006	In this study we have addressed the ability of the glycolipid transfer protein (GLTP) to transfer anthrylvinyl-galactosylceramide at different pH and sodium chloride concentrations, and the ability of three different mutants to transfer the fluorescently labeled galactosylceramide between donor and acceptor model membranes.	Sodium Chloride	150-165	glycolipid transfer protein	Homo sapiens	80-84
16908009-1	2006	In this study we have addressed the ability of the glycolipid transfer protein (GLTP) to transfer anthrylvinyl-galactosylceramide at different pH and sodium chloride concentrations, and the ability of three different mutants to transfer the fluorescently labeled galactosylceramide between donor and acceptor model membranes.	Galactosylceramides	111-129	glycolipid transfer protein	Homo sapiens	51-78
16908009-1	2006	In this study we have addressed the ability of the glycolipid transfer protein (GLTP) to transfer anthrylvinyl-galactosylceramide at different pH and sodium chloride concentrations, and the ability of three different mutants to transfer the fluorescently labeled galactosylceramide between donor and acceptor model membranes.	Galactosylceramides	111-129	glycolipid transfer protein	Homo sapiens	80-84
16908009-3	2006	Wild-type GLTP and W96 GLTP were both able to transfer anthrylvinyl-galactosylceramide, but the two variants W85 GLTP and W142 GLTP did not show any glycolipid transfer activity, indicating that the tryptophan in position 96 is crucial for transfer activity.	anthrylvinyl-galactosylceramide	55-86	glycolipid transfer protein	Homo sapiens	10-14
16908009-3	2006	Wild-type GLTP and W96 GLTP were both able to transfer anthrylvinyl-galactosylceramide, but the two variants W85 GLTP and W142 GLTP did not show any glycolipid transfer activity, indicating that the tryptophan in position 96 is crucial for transfer activity.	anthrylvinyl-galactosylceramide	55-86	glycolipid transfer protein	Homo sapiens	23-27
16908009-3	2006	Wild-type GLTP and W96 GLTP were both able to transfer anthrylvinyl-galactosylceramide, but the two variants W85 GLTP and W142 GLTP did not show any glycolipid transfer activity, indicating that the tryptophan in position 96 is crucial for transfer activity.	anthrylvinyl-galactosylceramide	55-86	glycolipid transfer protein	Homo sapiens	23-27
16908009-4	2006	Tryptophan fluorescence emission showed a blue shift of the maximal emission wavelength upon interaction of glycolipid containing vesicle with wild-type GLTP and W96 GLTP, while no blue shift was recorded for the protein variants W85 GLTP and W142 GLTP.	Tryptophan	0-10	glycolipid transfer protein	Homo sapiens	153-157
16908009-4	2006	Tryptophan fluorescence emission showed a blue shift of the maximal emission wavelength upon interaction of glycolipid containing vesicle with wild-type GLTP and W96 GLTP, while no blue shift was recorded for the protein variants W85 GLTP and W142 GLTP.	Tryptophan	0-10	glycolipid transfer protein	Homo sapiens	166-170
16908009-4	2006	Tryptophan fluorescence emission showed a blue shift of the maximal emission wavelength upon interaction of glycolipid containing vesicle with wild-type GLTP and W96 GLTP, while no blue shift was recorded for the protein variants W85 GLTP and W142 GLTP.	Tryptophan	0-10	glycolipid transfer protein	Homo sapiens	166-170
16908009-4	2006	Tryptophan fluorescence emission showed a blue shift of the maximal emission wavelength upon interaction of glycolipid containing vesicle with wild-type GLTP and W96 GLTP, while no blue shift was recorded for the protein variants W85 GLTP and W142 GLTP.	Glycolipids	108-118	glycolipid transfer protein	Homo sapiens	153-157
16908009-4	2006	Tryptophan fluorescence emission showed a blue shift of the maximal emission wavelength upon interaction of glycolipid containing vesicle with wild-type GLTP and W96 GLTP, while no blue shift was recorded for the protein variants W85 GLTP and W142 GLTP.	Glycolipids	108-118	glycolipid transfer protein	Homo sapiens	166-170
16908009-4	2006	Tryptophan fluorescence emission showed a blue shift of the maximal emission wavelength upon interaction of glycolipid containing vesicle with wild-type GLTP and W96 GLTP, while no blue shift was recorded for the protein variants W85 GLTP and W142 GLTP.	Glycolipids	108-118	glycolipid transfer protein	Homo sapiens	166-170
16908009-5	2006	The quantum yield of tryptophan emission was highest for the W96 GLTP protein whereas W85 GLTP, W142 GLTP and wild-type GLTP showed a lower and almost similar quantum yield.	Tryptophan	21-31	glycolipid transfer protein	Homo sapiens	65-69
16908009-7	2006	Again wild-type GLTP and W96 GLTP showed similar behavior in the presence of vesicles containing glycolipids.	Glycolipids	97-108	glycolipid transfer protein	Homo sapiens	16-20
16908009-7	2006	Again wild-type GLTP and W96 GLTP showed similar behavior in the presence of vesicles containing glycolipids.	Glycolipids	97-108	glycolipid transfer protein	Homo sapiens	29-33
16777057-1	2006	The glycolipid transfer protein (GLTP)-mediated movement of galactosylceramide from model membrane donor vesicles to acceptor vesicles is sensitive to the membrane environment surrounding the glycolipid.	Galactosylceramides	60-78	glycolipid transfer protein	Homo sapiens	33-37
16777057-1	2006	The glycolipid transfer protein (GLTP)-mediated movement of galactosylceramide from model membrane donor vesicles to acceptor vesicles is sensitive to the membrane environment surrounding the glycolipid.	Glycolipids	4-14	glycolipid transfer protein	Homo sapiens	33-37
16777057-2	2006	GLTP can catalyze the transfer of a fluorescently labeled GSL, anthrylvinyl-galactosylceramide (AV-GalCer), from vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and dipalmitoylphosphatidylcholine matrices, but not from vesicles prepared from N-palmitoylsphingomyelin, regardless of the cholesterol content of the vesicles.	anthrylvinyl-galactosylceramide	63-94	glycolipid transfer protein	Homo sapiens	0-4
16777057-2	2006	GLTP can catalyze the transfer of a fluorescently labeled GSL, anthrylvinyl-galactosylceramide (AV-GalCer), from vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and dipalmitoylphosphatidylcholine matrices, but not from vesicles prepared from N-palmitoylsphingomyelin, regardless of the cholesterol content of the vesicles.	av-galcer	96-105	glycolipid transfer protein	Homo sapiens	0-4
16777057-2	2006	GLTP can catalyze the transfer of a fluorescently labeled GSL, anthrylvinyl-galactosylceramide (AV-GalCer), from vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and dipalmitoylphosphatidylcholine matrices, but not from vesicles prepared from N-palmitoylsphingomyelin, regardless of the cholesterol content of the vesicles.	1-palmitoyl-2-oleoylphosphatidylcholine	134-182	glycolipid transfer protein	Homo sapiens	0-4
16777057-2	2006	GLTP can catalyze the transfer of a fluorescently labeled GSL, anthrylvinyl-galactosylceramide (AV-GalCer), from vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and dipalmitoylphosphatidylcholine matrices, but not from vesicles prepared from N-palmitoylsphingomyelin, regardless of the cholesterol content of the vesicles.	1,2-Dipalmitoylphosphatidylcholine	187-217	glycolipid transfer protein	Homo sapiens	0-4
18261224-1	2008	BACKGROUND: Glycolipid transfer protein is the prototypical and founding member of the new GLTP superfamily distinguished by a novel conformational fold and glycolipid binding motif.	Glycolipids	157-167	glycolipid transfer protein	Homo sapiens	12-39
18261224-1	2008	BACKGROUND: Glycolipid transfer protein is the prototypical and founding member of the new GLTP superfamily distinguished by a novel conformational fold and glycolipid binding motif.	Glycolipids	157-167	glycolipid transfer protein	Homo sapiens	91-95
17915897-1	2007	The glycolipid transfer protein (GLTP) is monomeric in aqueous solutions, and it binds weakly to membrane interfaces with or without glycolipids.	Glycolipids	133-144	glycolipid transfer protein	Homo sapiens	33-37
17915897-6	2007	If GLTP is injected under a palmitoyl-galactosylceramide monolayer above 30 mN/m, the presence of GLTP leads to a decrease in the surface pressure as a function of time.	palmitoyl-galactosylceramide	28-56	glycolipid transfer protein	Homo sapiens	3-7
17915897-6	2007	If GLTP is injected under a palmitoyl-galactosylceramide monolayer above 30 mN/m, the presence of GLTP leads to a decrease in the surface pressure as a function of time.	palmitoyl-galactosylceramide	28-56	glycolipid transfer protein	Homo sapiens	98-102
17915897-7	2007	This suggests that GLTP is able to remove glycolipids from the monolayer without penetrating the monolayer.	Glycolipids	42-53	glycolipid transfer protein	Homo sapiens	19-23
17320476-2	2007	GLTP specificity encompasses both sphingoid- and glycerol-based glycolipids, but with a strict requirement that the initial sugar residue be beta-linked to the hydrophobic lipid backbone.	Sphingosine	34-43	glycolipid transfer protein	Homo sapiens	0-4
17320476-2	2007	GLTP specificity encompasses both sphingoid- and glycerol-based glycolipids, but with a strict requirement that the initial sugar residue be beta-linked to the hydrophobic lipid backbone.	Glycerol	49-57	glycolipid transfer protein	Homo sapiens	0-4
17320476-2	2007	GLTP specificity encompasses both sphingoid- and glycerol-based glycolipids, but with a strict requirement that the initial sugar residue be beta-linked to the hydrophobic lipid backbone.	Glycolipids	64-75	glycolipid transfer protein	Homo sapiens	0-4
17320476-2	2007	GLTP specificity encompasses both sphingoid- and glycerol-based glycolipids, but with a strict requirement that the initial sugar residue be beta-linked to the hydrophobic lipid backbone.	Sugars	124-129	glycolipid transfer protein	Homo sapiens	0-4
17320476-6	2007	Based on the unique conformational architecture that targets GLTP to membranes and enables glycolipid binding, GLTP is now considered the prototypical and founding member of a new protein superfamily in eukaryotes.	Glycolipids	91-101	glycolipid transfer protein	Homo sapiens	111-115
17105344-4	2006	Here we report crystal structures of human GLTP bound to GSLs of diverse acyl chain length, unsaturation, and sugar composition.	Glycosphingolipids	57-61	glycolipid transfer protein	Homo sapiens	43-47
17105344-4	2006	Here we report crystal structures of human GLTP bound to GSLs of diverse acyl chain length, unsaturation, and sugar composition.	Sugars	110-115	glycolipid transfer protein	Homo sapiens	43-47
17105344-5	2006	Structural comparisons show a highly conserved anchoring of galactosyl- and lactosyl-amide headgroups by the GLTP recognition center.	galactosyl- and lactosyl-amide	60-90	glycolipid transfer protein	Homo sapiens	109-113
16777057-2	2006	GLTP can catalyze the transfer of a fluorescently labeled GSL, anthrylvinyl-galactosylceramide (AV-GalCer), from vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and dipalmitoylphosphatidylcholine matrices, but not from vesicles prepared from N-palmitoylsphingomyelin, regardless of the cholesterol content of the vesicles.	Cholesterol	308-319	glycolipid transfer protein	Homo sapiens	0-4
16777057-3	2006	In this study, we have examined the structural features of sphingomyelin (SM) that are responsible for its inhibition of the rate of GLTP-catalyzed transfer of AV-GalCer.	Sphingomyelins	59-72	glycolipid transfer protein	Homo sapiens	133-137
16777057-3	2006	In this study, we have examined the structural features of sphingomyelin (SM) that are responsible for its inhibition of the rate of GLTP-catalyzed transfer of AV-GalCer.	Sphingomyelins	74-76	glycolipid transfer protein	Homo sapiens	133-137
15901739-3	2005	Recent structural determinations of the apo- and glycolipid-liganded forms of human GLTP have provided the first insights into the molecular architecture of the protein and its glycolipid binding site (Malinina, L., Malakhova, M. L., Brown, R. E., and Patel, D. J.	Glycolipids	49-59	glycolipid transfer protein	Homo sapiens	84-88
16169991-3	2005	Glycolipid transfer protein (GLTP) catalyzes selective intermembrane transfer of GSLs.	Glycosphingolipids	81-85	glycolipid transfer protein	Homo sapiens	0-27
16169991-3	2005	Glycolipid transfer protein (GLTP) catalyzes selective intermembrane transfer of GSLs.	Glycosphingolipids	81-85	glycolipid transfer protein	Homo sapiens	29-33
16169991-4	2005	To enable effective use of GLTP as a tool to modify the glycolipid content of membranes, it is imperative to understand how the membrane regulates GLTP action.	Glycolipids	56-66	glycolipid transfer protein	Homo sapiens	27-31
16169991-5	2005	In this study, GLTP partitioning to membranes was analyzed by monitoring the fluorescence resonance energy transfer from tryptophans and tyrosines of GLTP to N-(5-dimethyl-aminonaphthalene-1-sulfonyl)-1,2-dihexadecanoyl-sn-glycero-3-phospho-ethanolamine present in bilayer vesicles.	Tryptophan	121-132	glycolipid transfer protein	Homo sapiens	15-19
16169991-5	2005	In this study, GLTP partitioning to membranes was analyzed by monitoring the fluorescence resonance energy transfer from tryptophans and tyrosines of GLTP to N-(5-dimethyl-aminonaphthalene-1-sulfonyl)-1,2-dihexadecanoyl-sn-glycero-3-phospho-ethanolamine present in bilayer vesicles.	Tryptophan	121-132	glycolipid transfer protein	Homo sapiens	150-154
16169991-5	2005	In this study, GLTP partitioning to membranes was analyzed by monitoring the fluorescence resonance energy transfer from tryptophans and tyrosines of GLTP to N-(5-dimethyl-aminonaphthalene-1-sulfonyl)-1,2-dihexadecanoyl-sn-glycero-3-phospho-ethanolamine present in bilayer vesicles.	Tyrosine	137-146	glycolipid transfer protein	Homo sapiens	15-19
16169991-5	2005	In this study, GLTP partitioning to membranes was analyzed by monitoring the fluorescence resonance energy transfer from tryptophans and tyrosines of GLTP to N-(5-dimethyl-aminonaphthalene-1-sulfonyl)-1,2-dihexadecanoyl-sn-glycero-3-phospho-ethanolamine present in bilayer vesicles.	Tyrosine	137-146	glycolipid transfer protein	Homo sapiens	150-154
16169991-5	2005	In this study, GLTP partitioning to membranes was analyzed by monitoring the fluorescence resonance energy transfer from tryptophans and tyrosines of GLTP to N-(5-dimethyl-aminonaphthalene-1-sulfonyl)-1,2-dihexadecanoyl-sn-glycero-3-phospho-ethanolamine present in bilayer vesicles.	n-(5-dimethyl-aminonaphthalene-1-sulfonyl)-1,2-dihexadecanoyl-sn-glycero-3-phospho-ethanolamine	158-253	glycolipid transfer protein	Homo sapiens	15-19
16169991-5	2005	In this study, GLTP partitioning to membranes was analyzed by monitoring the fluorescence resonance energy transfer from tryptophans and tyrosines of GLTP to N-(5-dimethyl-aminonaphthalene-1-sulfonyl)-1,2-dihexadecanoyl-sn-glycero-3-phospho-ethanolamine present in bilayer vesicles.	n-(5-dimethyl-aminonaphthalene-1-sulfonyl)-1,2-dihexadecanoyl-sn-glycero-3-phospho-ethanolamine	158-253	glycolipid transfer protein	Homo sapiens	150-154
16169991-7	2005	GLTP interaction with model membranes was nonpenetrating, as assessed by protein-induced changes in lipid monolayer surface pressure, and nonperturbing in that neither membrane fluidity nor order were affected, as monitored by anisotropy of 1,6-diphenyl-1,3,5-hexatriene and 6-dodecanoyl-N,N-dimethyl-2-naphthylamine, even though the tryptophan anisotropy of GLTP increased in the presence of vesicles.	Diphenylhexatriene	241-270	glycolipid transfer protein	Homo sapiens	0-4
16169991-7	2005	GLTP interaction with model membranes was nonpenetrating, as assessed by protein-induced changes in lipid monolayer surface pressure, and nonperturbing in that neither membrane fluidity nor order were affected, as monitored by anisotropy of 1,6-diphenyl-1,3,5-hexatriene and 6-dodecanoyl-N,N-dimethyl-2-naphthylamine, even though the tryptophan anisotropy of GLTP increased in the presence of vesicles.	laurdan	275-316	glycolipid transfer protein	Homo sapiens	0-4
16169991-7	2005	GLTP interaction with model membranes was nonpenetrating, as assessed by protein-induced changes in lipid monolayer surface pressure, and nonperturbing in that neither membrane fluidity nor order were affected, as monitored by anisotropy of 1,6-diphenyl-1,3,5-hexatriene and 6-dodecanoyl-N,N-dimethyl-2-naphthylamine, even though the tryptophan anisotropy of GLTP increased in the presence of vesicles.	Tryptophan	334-344	glycolipid transfer protein	Homo sapiens	0-4
15901739-9	2005	Two manifestations of point mutation within the liganding site were apparent: (i) impaired formation of the GLTP/glycolipid complex; (ii) impaired acquisition and release of bound glycolipid by GLTP.	Glycolipids	113-123	glycolipid transfer protein	Homo sapiens	108-112
15901739-9	2005	Two manifestations of point mutation within the liganding site were apparent: (i) impaired formation of the GLTP/glycolipid complex; (ii) impaired acquisition and release of bound glycolipid by GLTP.	Glycolipids	113-123	glycolipid transfer protein	Homo sapiens	194-198
15901739-9	2005	Two manifestations of point mutation within the liganding site were apparent: (i) impaired formation of the GLTP/glycolipid complex; (ii) impaired acquisition and release of bound glycolipid by GLTP.	Glycolipids	180-190	glycolipid transfer protein	Homo sapiens	194-198
15901739-10	2005	The results are consistent with a carrier-based mode of GLTP action to accomplish the intermembrane transfer of glycolipid.	Glycolipids	112-122	glycolipid transfer protein	Homo sapiens	56-60
16309699-3	2006	The 1.4 angstroms structure resembles the recently characterized apo-form of the human GLTP but the other two structures represent an intermediate conformation of the apo-GLTPs and the human lactosylceramide-bound GLTP structure.	CDw17 antigen	191-207	glycolipid transfer protein	Homo sapiens	87-91
15901739-6	2005	Different approaches were developed to rapidly and efficiently assess the uptake and release of glycolipid by GLTP.	Glycolipids	96-106	glycolipid transfer protein	Homo sapiens	110-114
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	beta-linked	99-110	glycolipid transfer protein	Homo sapiens	0-27
15893510-1	2005	The mammalian glycolipid transfer protein, GLTP, catalyzes the transfer in vitro of glycolipids between membranes.	Glycolipids	84-95	glycolipid transfer protein	Homo sapiens	43-47
15893510-2	2005	In this study we have examined on one hand the effect of the variations in the donor vesicle composition and on the other hand the effects of variations in the acceptor vesicle composition on the GLTP-catalyzed transfer kinetics of galactosylceramide between bilayer vesicles.	Galactosylceramides	232-250	glycolipid transfer protein	Homo sapiens	196-200
15893510-8	2005	Based on these experiments we conclude that the GLTP mediated transfer of anthrylvinyl-galactosylceramide is sensitive to the matrix lipid composition and membrane bending.	anthrylvinyl-galactosylceramide	74-105	glycolipid transfer protein	Homo sapiens	48-52
15893510-10	2005	On the other hand GLTP can more easily transfer glycolipids to "lipid raft" like membranes, suggesting that the protein could be involved in raft assembly.	Glycolipids	48-59	glycolipid transfer protein	Homo sapiens	18-22
15504043-0	2004	Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses.	Glycosphingolipids	49-67	glycolipid transfer protein	Homo sapiens	0-27
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	beta-linked	99-110	glycolipid transfer protein	Homo sapiens	29-33
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Sugars	92-98	glycolipid transfer protein	Homo sapiens	0-27
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Sugars	92-98	glycolipid transfer protein	Homo sapiens	29-33
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Diglycerides	121-135	glycolipid transfer protein	Homo sapiens	0-27
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Diglycerides	121-135	glycolipid transfer protein	Homo sapiens	29-33
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Ceramides	139-147	glycolipid transfer protein	Homo sapiens	0-27
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Ceramides	139-147	glycolipid transfer protein	Homo sapiens	29-33
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Glycosphingolipids	176-194	glycolipid transfer protein	Homo sapiens	0-27
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Glycosphingolipids	176-194	glycolipid transfer protein	Homo sapiens	29-33
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Glycosphingolipids	196-200	glycolipid transfer protein	Homo sapiens	0-27
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Glycosphingolipids	196-200	glycolipid transfer protein	Homo sapiens	29-33
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Gangliosides	206-218	glycolipid transfer protein	Homo sapiens	0-27
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Gangliosides	206-218	glycolipid transfer protein	Homo sapiens	29-33
15329726-3	2004	Here we report crystal structures of apo-GLTP (1.65 A resolution) and lactosylceramide-bound (1.95 A) GLTP, in which the bound glycosphingolipid is sandwiched, after adaptive recognition, within a previously unknown two-layer all-alpha-helical topology.	CDw17 antigen	70-86	glycolipid transfer protein	Homo sapiens	102-106
15329726-3	2004	Here we report crystal structures of apo-GLTP (1.65 A resolution) and lactosylceramide-bound (1.95 A) GLTP, in which the bound glycosphingolipid is sandwiched, after adaptive recognition, within a previously unknown two-layer all-alpha-helical topology.	Glycosphingolipids	127-144	glycolipid transfer protein	Homo sapiens	41-45
15329726-3	2004	Here we report crystal structures of apo-GLTP (1.65 A resolution) and lactosylceramide-bound (1.95 A) GLTP, in which the bound glycosphingolipid is sandwiched, after adaptive recognition, within a previously unknown two-layer all-alpha-helical topology.	Glycosphingolipids	127-144	glycolipid transfer protein	Homo sapiens	102-106
15329726-4	2004	Glycosphingolipid binding specificity is achieved through recognition and anchoring of the sugar-amide headgroup to the GLTP recognition centre by hydrogen bond networks and hydrophobic contacts, and encapsulation of both lipid chains, in a precisely oriented manner within a "moulded-to-fit" hydrophobic tunnel.	Glycosphingolipids	0-17	glycolipid transfer protein	Homo sapiens	120-124
15329726-4	2004	Glycosphingolipid binding specificity is achieved through recognition and anchoring of the sugar-amide headgroup to the GLTP recognition centre by hydrogen bond networks and hydrophobic contacts, and encapsulation of both lipid chains, in a precisely oriented manner within a "moulded-to-fit" hydrophobic tunnel.	sugar-amide	91-102	glycolipid transfer protein	Homo sapiens	120-124
15329726-4	2004	Glycosphingolipid binding specificity is achieved through recognition and anchoring of the sugar-amide headgroup to the GLTP recognition centre by hydrogen bond networks and hydrophobic contacts, and encapsulation of both lipid chains, in a precisely oriented manner within a "moulded-to-fit" hydrophobic tunnel.	Hydrogen	147-155	glycolipid transfer protein	Homo sapiens	120-124
15329726-5	2004	A cleft-like conformational gating mechanism, involving two interhelical loops and one alpha-helix of GLTP, could enable the glycolipid chains to enter and leave the tunnel in the membrane-associated state.	Glycolipids	125-135	glycolipid transfer protein	Homo sapiens	102-106
11772025-7	2002	The pool of AV-GalCer available for GLTP-mediated transfer also was smaller in vesicles containing high sphingomyelin content.	Sphingomyelins	104-117	glycolipid transfer protein	Homo sapiens	36-40
11772025-9	2002	Our results show that GLTP acts as a sensitive probe for detecting interactions of glycosphingolipids with neighboring lipids and that the lateral mixing of glycolipids is probably affected by the matrix lipid composition.	Glycosphingolipids	83-101	glycolipid transfer protein	Homo sapiens	22-26
10653652-2	2000	The glycolipid transfer protein (23-24 kDa, pI 9.0) catalyzes the high specificity transfer of lipids that have sugars beta-linked to either a ceramide or a diacylglycerol backbone, such as simple glycolipids and gangliosides, but not the transfer of phospholipids, cholesterol, or cholesterol esters.	Sugars	112-118	glycolipid transfer protein	Homo sapiens	4-31
10653652-2	2000	The glycolipid transfer protein (23-24 kDa, pI 9.0) catalyzes the high specificity transfer of lipids that have sugars beta-linked to either a ceramide or a diacylglycerol backbone, such as simple glycolipids and gangliosides, but not the transfer of phospholipids, cholesterol, or cholesterol esters.	Ceramides	143-151	glycolipid transfer protein	Homo sapiens	4-31
10653652-2	2000	The glycolipid transfer protein (23-24 kDa, pI 9.0) catalyzes the high specificity transfer of lipids that have sugars beta-linked to either a ceramide or a diacylglycerol backbone, such as simple glycolipids and gangliosides, but not the transfer of phospholipids, cholesterol, or cholesterol esters.	Diglycerides	157-171	glycolipid transfer protein	Homo sapiens	4-31
10653652-2	2000	The glycolipid transfer protein (23-24 kDa, pI 9.0) catalyzes the high specificity transfer of lipids that have sugars beta-linked to either a ceramide or a diacylglycerol backbone, such as simple glycolipids and gangliosides, but not the transfer of phospholipids, cholesterol, or cholesterol esters.	Glycolipids	197-208	glycolipid transfer protein	Homo sapiens	4-31
10653652-2	2000	The glycolipid transfer protein (23-24 kDa, pI 9.0) catalyzes the high specificity transfer of lipids that have sugars beta-linked to either a ceramide or a diacylglycerol backbone, such as simple glycolipids and gangliosides, but not the transfer of phospholipids, cholesterol, or cholesterol esters.	Gangliosides	213-225	glycolipid transfer protein	Homo sapiens	4-31
10653652-2	2000	The glycolipid transfer protein (23-24 kDa, pI 9.0) catalyzes the high specificity transfer of lipids that have sugars beta-linked to either a ceramide or a diacylglycerol backbone, such as simple glycolipids and gangliosides, but not the transfer of phospholipids, cholesterol, or cholesterol esters.	Phospholipids	251-264	glycolipid transfer protein	Homo sapiens	4-31
10653652-2	2000	The glycolipid transfer protein (23-24 kDa, pI 9.0) catalyzes the high specificity transfer of lipids that have sugars beta-linked to either a ceramide or a diacylglycerol backbone, such as simple glycolipids and gangliosides, but not the transfer of phospholipids, cholesterol, or cholesterol esters.	Cholesterol	266-277	glycolipid transfer protein	Homo sapiens	4-31
10653652-2	2000	The glycolipid transfer protein (23-24 kDa, pI 9.0) catalyzes the high specificity transfer of lipids that have sugars beta-linked to either a ceramide or a diacylglycerol backbone, such as simple glycolipids and gangliosides, but not the transfer of phospholipids, cholesterol, or cholesterol esters.	Cholesterol Esters	282-300	glycolipid transfer protein	Homo sapiens	4-31
15287756-1	2004	Glycolipid transfer protein (GLTP) is a soluble 24 kDa protein that selectively accelerates the intermembrane transfer of glycolipids in vitro.	Glycolipids	122-133	glycolipid transfer protein	Homo sapiens	0-27
15287756-1	2004	Glycolipid transfer protein (GLTP) is a soluble 24 kDa protein that selectively accelerates the intermembrane transfer of glycolipids in vitro.	Glycolipids	122-133	glycolipid transfer protein	Homo sapiens	29-33
15287756-3	2004	Here, we report the cloning of human GLTP and characterize the environment of the three tryptophans (Trps) of the protein using fluorescence spectroscopy.	Tryptophan	88-99	glycolipid transfer protein	Homo sapiens	37-41
15287756-3	2004	Here, we report the cloning of human GLTP and characterize the environment of the three tryptophans (Trps) of the protein using fluorescence spectroscopy.	Tryptophan	101-105	glycolipid transfer protein	Homo sapiens	37-41
15287756-6	2004	Insights into reversible conformational changes accompanying changes in GLTP activity were provided by addition and rapid dilution of urea while monitoring changes in Trp or 1-anilinonaphthalene-8-sulfonic acid fluorescence.	Urea	134-138	glycolipid transfer protein	Homo sapiens	72-76
15287756-6	2004	Insights into reversible conformational changes accompanying changes in GLTP activity were provided by addition and rapid dilution of urea while monitoring changes in Trp or 1-anilinonaphthalene-8-sulfonic acid fluorescence.	Tryptophan	167-170	glycolipid transfer protein	Homo sapiens	72-76
15287756-6	2004	Insights into reversible conformational changes accompanying changes in GLTP activity were provided by addition and rapid dilution of urea while monitoring changes in Trp or 1-anilinonaphthalene-8-sulfonic acid fluorescence.	1-anilino-8-naphthalenesulfonate	174-210	glycolipid transfer protein	Homo sapiens	72-76
15287756-7	2004	Incubation of GLTP with glycolipid liposomes caused a blue shift in the Trp emission maximum but diminished the fluorescence intensity.	Tryptophan	72-75	glycolipid transfer protein	Homo sapiens	14-18
15287756-8	2004	The blue-shifted emission maximum, centered near 335 nm, persisted after separation of glycolipid liposomes from GLTP, consistent with formation of a GLTP-glycolipid complex at a glycolipid-liganding site containing Trp.	Glycolipids	87-97	glycolipid transfer protein	Homo sapiens	150-154
15287756-8	2004	The blue-shifted emission maximum, centered near 335 nm, persisted after separation of glycolipid liposomes from GLTP, consistent with formation of a GLTP-glycolipid complex at a glycolipid-liganding site containing Trp.	Glycolipids	155-165	glycolipid transfer protein	Homo sapiens	113-117
15287756-8	2004	The blue-shifted emission maximum, centered near 335 nm, persisted after separation of glycolipid liposomes from GLTP, consistent with formation of a GLTP-glycolipid complex at a glycolipid-liganding site containing Trp.	Glycolipids	155-165	glycolipid transfer protein	Homo sapiens	150-154
15287756-8	2004	The blue-shifted emission maximum, centered near 335 nm, persisted after separation of glycolipid liposomes from GLTP, consistent with formation of a GLTP-glycolipid complex at a glycolipid-liganding site containing Trp.	Glycolipids	155-165	glycolipid transfer protein	Homo sapiens	113-117
15287756-8	2004	The blue-shifted emission maximum, centered near 335 nm, persisted after separation of glycolipid liposomes from GLTP, consistent with formation of a GLTP-glycolipid complex at a glycolipid-liganding site containing Trp.	Glycolipids	155-165	glycolipid transfer protein	Homo sapiens	150-154
15287756-8	2004	The blue-shifted emission maximum, centered near 335 nm, persisted after separation of glycolipid liposomes from GLTP, consistent with formation of a GLTP-glycolipid complex at a glycolipid-liganding site containing Trp.	Tryptophan	216-219	glycolipid transfer protein	Homo sapiens	113-117
15287756-8	2004	The blue-shifted emission maximum, centered near 335 nm, persisted after separation of glycolipid liposomes from GLTP, consistent with formation of a GLTP-glycolipid complex at a glycolipid-liganding site containing Trp.	Tryptophan	216-219	glycolipid transfer protein	Homo sapiens	150-154
15287756-9	2004	The results provide the first insights into human GLTP structural dynamics by fluorescence spectroscopy, including global conformational changes that accompany GLTP folding into an active conformational state as well as more subtle conformational changes that play a role in GLTP-mediated transfer of glycolipids between membranes, and establish a foundation for future studies of membrane rafts using GLTP.	Glycolipids	301-312	glycolipid transfer protein	Homo sapiens	50-54