PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
10077592-7	1999	The antibody-stimulated assembly of focal adhesions and actin stress fibers in cells plated on the cell-binding domain of fibronectin can be blocked with C3 exotransferase, an inhibitor of the small GTP-binding protein Rho.	Guanosine Triphosphate	199-202	fibronectin 1	Mus musculus	122-133
10077592-8	1999	Treatment of cells with lysophosphatidic acid, which activates Rho, results in full spreading and assembly of focal adhesions and actin stress fibers in fibroblasts plated on the cell-binding domain of fibronectin.	lysophosphatidic acid	24-45	fibronectin 1	Mus musculus	202-213
10091926-4	1999	Adsorption of fibronectin onto the plain and periodate-oxidized poly(EGDMA/HEMA) microbeads were very similar, and were 0.025-0.035 mg fibronectin per g polymer, respectively.	metaperiodate	45-54	fibronectin 1	Mus musculus	14-25
10591131-4	1999	Fibronectin adsorption on the polymer surface from a cell culture medium was determined by immunoassay.	Polymers	30-37	fibronectin 1	Mus musculus	0-11
10591131-10	1999	Thus, it could be concluded that since the PMB could suppress cell adhesion proteins e.g. fibronectin, the PMB showed excellent cell adhesive resistance properties.	Polymyxin B	43-46	fibronectin 1	Mus musculus	90-101
10591131-10	1999	Thus, it could be concluded that since the PMB could suppress cell adhesion proteins e.g. fibronectin, the PMB showed excellent cell adhesive resistance properties.	Polymyxin B	107-110	fibronectin 1	Mus musculus	90-101
9840945-4	1998	Adhesion of both normal and transformed cells to fibronectin or other extracellular matrix proteins consistently induces the tyrosine-phosphorylation of C3G.	Tyrosine	125-133	fibronectin 1	Mus musculus	49-60
9813103-5	1998	Attachment to fibronectin induces tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin in parental cells and cells transfected with the wild-type PTP1B, while in cells transfected with the mutant PTP1B, such induction is not observed.	Tyrosine	34-42	fibronectin 1	Mus musculus	14-25
9787189-2	1998	In this study we show that high concentrations of soluble calcium induce the detachment of BM CD34(+) HPC adherent on fibronectin, a major component of BM extracellular matrix.	Calcium	58-65	fibronectin 1	Mus musculus	118-129
9842895-5	1998	Blood leukocytes isolated from mice treated with tyrphostin AG490 were less adhesive on VCAM-1 and fibronectin, when compared with control animals.	Tyrphostins	49-59	fibronectin 1	Mus musculus	99-110
9774338-4	1998	Pyk2 tyrosine phosphorylation was enhanced by fibronectin (FN) stimulation of FAK- but not FAK+ cells.	Tyrosine	5-13	fibronectin 1	Mus musculus	46-57
9740005-3	1998	The surface micropattern appeared and disappeared interchangeably, as observed under a phase-contrast microscope, by varying the temperature between 10 degrees C and 37 degrees C. The copolymer-grafted polystyrene surface was hydrophobic at 37 degrees C and hydrophilic at 10 degrees C. Albumin and fibronectin adsorption on the matrix was investigated using the fluorescent-labeling method.	copolymer	184-193	fibronectin 1	Mus musculus	299-310
9740005-3	1998	The surface micropattern appeared and disappeared interchangeably, as observed under a phase-contrast microscope, by varying the temperature between 10 degrees C and 37 degrees C. The copolymer-grafted polystyrene surface was hydrophobic at 37 degrees C and hydrophilic at 10 degrees C. Albumin and fibronectin adsorption on the matrix was investigated using the fluorescent-labeling method.	Polystyrenes	202-213	fibronectin 1	Mus musculus	299-310
9730985-7	1998	Arg-Gly-Asp peptides or fragments of fibronectin that contain the Arg-Gly-Asp cell binding site promoted clustering of the (&agr ;)5beta1 integrin in focal adhesions, but did not enhance cell growth.	Arginine	0-3	fibronectin 1	Mus musculus	37-48
9731751-0	1998	Activation of the sodium/hydrogen exchanger via the fibronectin-integrin pathway results in hematopoietic stimulation.	Sodium	18-24	fibronectin 1	Mus musculus	52-63
9731751-0	1998	Activation of the sodium/hydrogen exchanger via the fibronectin-integrin pathway results in hematopoietic stimulation.	Hydrogen	25-33	fibronectin 1	Mus musculus	52-63
9731751-13	1998	Furthermore, addition of antibodies to fibronectin or the alpha4 integrin subunit to HCDC also reduced the pH, to a similar level to that found for 5-HMA.	5-(N,N-hexamethylene)amiloride	148-153	fibronectin 1	Mus musculus	39-50
9683792-4	1998	Treatment of cells cultured on fibronectin with a short pulse of the S phase chemotherapeutic agent camptothecin, resulted in a relative protection from cell death when compared to cells cultured on tissue culture plastic.	Camptothecin	100-112	fibronectin 1	Mus musculus	31-42
9727075-2	1998	We have previously found that mouse hematopoietic stem cells could be transduced on a FN fragment that included the recognition sequence Arg-Gly-Asp (RGD), suggesting that stem cells may express the integrin very late antigen (VLA)-5.	Arginine	137-140	fibronectin 1	Mus musculus	86-88
9727075-2	1998	We have previously found that mouse hematopoietic stem cells could be transduced on a FN fragment that included the recognition sequence Arg-Gly-Asp (RGD), suggesting that stem cells may express the integrin very late antigen (VLA)-5.	Glycine	141-144	fibronectin 1	Mus musculus	86-88
9727075-2	1998	We have previously found that mouse hematopoietic stem cells could be transduced on a FN fragment that included the recognition sequence Arg-Gly-Asp (RGD), suggesting that stem cells may express the integrin very late antigen (VLA)-5.	Aspartic Acid	145-148	fibronectin 1	Mus musculus	86-88
9774338-4	1998	Pyk2 tyrosine phosphorylation was enhanced by fibronectin (FN) stimulation of FAK- but not FAK+ cells.	Tyrosine	5-13	fibronectin 1	Mus musculus	59-61
10091939-7	1998	Stimulation of B16a cells with a PKC-activator, 12(S)-HETE, induced translocation of the high-affinity integrin from an intracellular pool to the plasma membrane, which resulted in increased tumor cell adhesion to fibronectin.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	48-58	fibronectin 1	Mus musculus	214-225
9717567-9	1998	In cells growing on a fibronectin layer, very strong activity of 3 beta-HSD and 17 beta-HSD and an increase in steroid hormone levels were observed.	beta-hsd	67-75	fibronectin 1	Mus musculus	22-33
9717567-9	1998	In cells growing on a fibronectin layer, very strong activity of 3 beta-HSD and 17 beta-HSD and an increase in steroid hormone levels were observed.	beta-hsd	83-91	fibronectin 1	Mus musculus	22-33
9717567-9	1998	In cells growing on a fibronectin layer, very strong activity of 3 beta-HSD and 17 beta-HSD and an increase in steroid hormone levels were observed.	Steroids	111-126	fibronectin 1	Mus musculus	22-33
9696493-8	1998	We also assessed the effects of pentoxifylline on the adhesive properties of T lymphocytes to fibronectin, as a paradigm for immune cell-extracellular matrix interactions required for migration.	Pentoxifylline	32-46	fibronectin 1	Mus musculus	94-105
9696493-10	1998	Pentoxifylline also inhibited the binding of murine T cells to fibronectin.	Pentoxifylline	0-14	fibronectin 1	Mus musculus	63-74
9548730-2	1998	Previous work demonstrated that one component in serum that promotes the assembly of fibronectin is lysophosphatidic acid (Zhang, Q., W.J.	lysophosphatidic acid	100-121	fibronectin 1	Mus musculus	85-96
9872601-2	1998	Ca-SP significantly inhibited the invasion of these tumor cells through Matrigel/fibronectin-coated filters.	spirulan	0-5	fibronectin 1	Mus musculus	81-92
9572482-5	1998	Culturing 3T3-L1 preadipose cells on fibronectin, a component of the ECM induced by TGFbeta, also inhibited insulin-dependent IRS-1 tyrosine phosphorylation and adipogenesis, supporting a role for ECM in mediating TGFbeta"s inhibitory effect on insulin signaling.	Tyrosine	132-140	fibronectin 1	Mus musculus	37-48
9548730-11	1998	Here we show that C3 transferase, an inhibitor of the low molecular weight GTP-binding protein Rho, blocks the binding of fibronectin and the 70-kD NH2-terminal fibronectin fragment to cells and blocks the assembly of fibronectin into matrix induced by serum or lysophosphatidic acid.	Guanosine Triphosphate	75-78	fibronectin 1	Mus musculus	122-133
9548730-11	1998	Here we show that C3 transferase, an inhibitor of the low molecular weight GTP-binding protein Rho, blocks the binding of fibronectin and the 70-kD NH2-terminal fibronectin fragment to cells and blocks the assembly of fibronectin into matrix induced by serum or lysophosphatidic acid.	Guanosine Triphosphate	75-78	fibronectin 1	Mus musculus	161-172
9548730-11	1998	Here we show that C3 transferase, an inhibitor of the low molecular weight GTP-binding protein Rho, blocks the binding of fibronectin and the 70-kD NH2-terminal fibronectin fragment to cells and blocks the assembly of fibronectin into matrix induced by serum or lysophosphatidic acid.	Guanosine Triphosphate	75-78	fibronectin 1	Mus musculus	161-172
9548730-11	1998	Here we show that C3 transferase, an inhibitor of the low molecular weight GTP-binding protein Rho, blocks the binding of fibronectin and the 70-kD NH2-terminal fibronectin fragment to cells and blocks the assembly of fibronectin into matrix induced by serum or lysophosphatidic acid.	lysophosphatidic acid	262-283	fibronectin 1	Mus musculus	122-133
9548730-15	1998	However, several inhibitors of cellular contractility, that differ in their mode of action, inhibit cell binding of fibronectin and the 70-kD NH2-terminal fibronectin fragment, decrease fibronectin incorporation into the deoxycholate insoluble matrix, and prevent fibronectin"s assembly into fibrils on the cell surface.	Deoxycholic Acid	221-233	fibronectin 1	Mus musculus	116-127
9365540-0	1997	Retinoic acid downregulates growth, fibronectin and RAR alpha in 3T3 cells: Ha-ras blocks this response and RA metabolism.	Tretinoin	0-13	fibronectin 1	Mus musculus	36-47
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Staurosporine	79-92	fibronectin 1	Mus musculus	186-188
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Staurosporine	79-92	fibronectin 1	Mus musculus	193-195
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Tetradecanoylphorbol Acetate	113-138	fibronectin 1	Mus musculus	186-188
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Tetradecanoylphorbol Acetate	113-138	fibronectin 1	Mus musculus	193-195
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Tetradecanoylphorbol Acetate	140-143	fibronectin 1	Mus musculus	186-188
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Tetradecanoylphorbol Acetate	140-143	fibronectin 1	Mus musculus	193-195
12174299-0	1998	Study on the Mechanism of Fibronectin Adhesion to NIH3T3 cell Stimulated by Retinoic Acid.	Tretinoin	76-89	fibronectin 1	Mus musculus	26-37
12174299-4	1998	The cell adhesion to fibronectin was promoted by 20% with 32 &mgr;mol/L RA, but not to polylysine.	Adenosine Monophosphate	62-65	fibronectin 1	Mus musculus	21-32
12174299-4	1998	The cell adhesion to fibronectin was promoted by 20% with 32 &mgr;mol/L RA, but not to polylysine.	Tretinoin	76-78	fibronectin 1	Mus musculus	21-32
9582107-11	1998	Fibronectin expression was marked in the control and hydralazine groups.	Hydralazine	53-64	fibronectin 1	Mus musculus	0-11
9502075-0	1998	Adhesion to fibronectin"s EDb domain induces tyrosine phosphorylation of focal adhesion proteins in Balb/c 3T3 cells.	Tyrosine	45-53	fibronectin 1	Mus musculus	12-23
9502081-1	1998	A series of pseudo-peptide analogs of the Arg-Gly-Asp (RGD) sequence of fibronectin have been synthesized, and their anti-metastatic effects in mice and inhibitory effects on tumor cell invasion in vitro have been examined.	arginyl-glycyl-aspartic acid	42-53	fibronectin 1	Mus musculus	72-83
9415455-6	1997	RESULTS: Particulate/fibrillar fibronectin and fibrillar type I collagen were observed in the thick cardiac jelly of the control heart at the onset of mesenchymal formation.	cardiac jelly	100-113	fibronectin 1	Mus musculus	31-42
9415455-7	1997	In the RA-treated heart, an intermittent patchy staining for fibronectin and a sparse distribution of type I collagen were observed in the thin cardiac jelly.	Tretinoin	7-9	fibronectin 1	Mus musculus	61-72
9365540-1	1997	Retinoic acid (RA) reduced growth, fibronectin, and retinoic acid receptor (RAR alpha) in NIH 3T3 cells but not in cells transformed by the Ha-ras oncogene.	Tretinoin	0-13	fibronectin 1	Mus musculus	35-46
9434254-3	1997	We have used synthetic or recombinant polypeptide analogues containing the Arg-Gly-Asp (RGD) sequence found in the functional domains of fibronectin, such as poly(RGD) or CH-271, to regulate the mechanisms involved in cell adhesion during the metastatic process.	arginyl-glycyl-aspartic acid	75-86	fibronectin 1	Mus musculus	137-148
9396155-3	1997	Hybrids of a fibronectin-related peptide[Arg-Gly-Asp (RGD)] with poly(ethylene glycol) (PEG) analogs were prepared by a simple and easy procedure.	arginyl-glycyl-aspartic acid	41-52	fibronectin 1	Mus musculus	13-24
9369356-5	1997	Stimulation by serum (1 or 10% mouse serum) or serum components, such as fibronectin (25 microg/ml) and albumin (500 microg/ml), alone strongly augmented only the lysosomal enzyme activity of alveolar macrophages, but it had no effect on nitric oxide secretion from cells, and no synergism or additive-like effect was observed between serum components and SSG.	Nitric Oxide	238-250	fibronectin 1	Mus musculus	73-84
21528271-1	1997	Echistatin, a low molecular weight, RGD-containing protein isolated from the venom of Echis carinatus, inhibited Lewis lung carcinoma cell (3LL) adhesion to immobilized fibronectin and laminin.	echistatin	0-10	fibronectin 1	Mus musculus	169-180
21528271-3	1997	Echistatin showed a stronger activity in inhibiting cell adhesion to fibronectin rather than to laminin and it resulted about 3-fold more effective than kistrin, an other ROD-snake venom protein, in inhibiting 3LL cell attachment to both substrates.	echistatin	0-10	fibronectin 1	Mus musculus	69-80
27006573-6	1997	After administration of gamma-IFN, only 3 infected mice had 2+ grade of fibronectin at the 20(th) week, and 2 mice had 3+ grade of type III collagen at the 24(th) week, and none of them reached 4+ grade, which were significantly less than the untreated group at the same stage (P < 0.01-0.05).	gamma-ifn	24-33	fibronectin 1	Mus musculus	72-83
9190883-3	1997	Our study examines whether rebamipide could ameliorate the pathophysiology associated with experimental diabetes in vivo, such as microalbuminuria, and to reverse the increased production of transforming growth factor-beta1 and fibronectin in SV-40 transformed murine mesangial cells in culture that were stimulated with high glucose.	rebamipide	27-37	fibronectin 1	Mus musculus	228-239
10920895-7	1997	In addition, 4-APR inhibited B16-F10 cell adherence to laminin, fibronectin and Matrigel, and induced CNE-2Z cell TIMP-1 mRNA expression.	4-acetamidophenyl retinoate	13-18	fibronectin 1	Mus musculus	64-75
9365540-1	1997	Retinoic acid (RA) reduced growth, fibronectin, and retinoic acid receptor (RAR alpha) in NIH 3T3 cells but not in cells transformed by the Ha-ras oncogene.	Tretinoin	15-17	fibronectin 1	Mus musculus	35-46
9270872-0	1997	Echistatin induces decrease of pp125FAK phosphorylation, disassembly of actin cytoskeleton and focal adhesions, and detachment of fibronectin-adherent melanoma cells.	echistatin	0-10	fibronectin 1	Mus musculus	130-141
9270872-1	1997	B16-BL6 mouse melanoma cells cultured on fibronectin-coated dishes were detached by treatment with echistatin, an RGD-containing disintegrin.	echistatin	99-109	fibronectin 1	Mus musculus	41-52
9270872-6	1997	Echistatin treatment down-regulated the phosphorylation of pp125FAK in fibronectin-adherent cells in a dose- and time-dependent fashion.	echistatin	0-10	fibronectin 1	Mus musculus	71-82
9219735-10	1997	PTX also increased membrane fluidity of the Neuro2a cells and significantly decreased tumor cell adhesion to fibronectin-coated microtiter wells (P < 0.01).	Pentoxifylline	0-3	fibronectin 1	Mus musculus	109-120
9126751-8	1997	An adhesion assay with extracellular matrix proteins demonstrated that C1300 NB cells adhered preferentially to vitronectin and fibronectin, and the adherence was strongly inhibited by Arg-Gly-Asp (RGD)-containing peptides.	Arginine	185-188	fibronectin 1	Mus musculus	128-139
9126751-8	1997	An adhesion assay with extracellular matrix proteins demonstrated that C1300 NB cells adhered preferentially to vitronectin and fibronectin, and the adherence was strongly inhibited by Arg-Gly-Asp (RGD)-containing peptides.	glycylaspartic acid	189-196	fibronectin 1	Mus musculus	128-139
9062384-1	1997	Chondroitin sulfate dipalmitoylphosphatidylethanolamine (CS-PE), when immobilized onto substratum, inhibited the adhesion of B16F10 mouse melanoma cells to fibronectin-coated dishes (anti-adhesion activity).	chondroitin sulfate dipalmitoylphosphatidylethanolamine	0-55	fibronectin 1	Mus musculus	156-167
9062384-1	1997	Chondroitin sulfate dipalmitoylphosphatidylethanolamine (CS-PE), when immobilized onto substratum, inhibited the adhesion of B16F10 mouse melanoma cells to fibronectin-coated dishes (anti-adhesion activity).	cs-pe	57-62	fibronectin 1	Mus musculus	156-167
9024778-8	1997	The degradation of FN is blocked by either serine protease inhibitors or goat anti-human tPA.	Tetradecanoylphorbol Acetate	89-92	fibronectin 1	Mus musculus	19-21
9024778-9	1997	Our data suggest that enhanced production of tPA during PE outgrowth may facilitate the migratory behavior of PE cells by mediating the degradation of ECM components such as FN.	Tetradecanoylphorbol Acetate	45-48	fibronectin 1	Mus musculus	174-176
8996642-2	1996	Synthesis and antimetastatic effects of peptides and peptide-poly(ethylene glycol) hybrids related to the core sequence of the type III connecting segment domain of fibronectin.	Ethylene Glycol	66-81	fibronectin 1	Mus musculus	165-176
9009142-1	1997	The results of our previous studies of mouse embryo fibroblasts showed that fibronectin expression and fibronectin receptor expression are tightly coregulated and that fibronectin modulates expression of its receptor in response to treatment with the differentiation-inducing agent N,N,-dimethylformamide (Varani and Chakrabarty, 1990, J.	Dimethylformamide	282-304	fibronectin 1	Mus musculus	76-87
9009142-1	1997	The results of our previous studies of mouse embryo fibroblasts showed that fibronectin expression and fibronectin receptor expression are tightly coregulated and that fibronectin modulates expression of its receptor in response to treatment with the differentiation-inducing agent N,N,-dimethylformamide (Varani and Chakrabarty, 1990, J.	Dimethylformamide	282-304	fibronectin 1	Mus musculus	103-114
9009142-1	1997	The results of our previous studies of mouse embryo fibroblasts showed that fibronectin expression and fibronectin receptor expression are tightly coregulated and that fibronectin modulates expression of its receptor in response to treatment with the differentiation-inducing agent N,N,-dimethylformamide (Varani and Chakrabarty, 1990, J.	Dimethylformamide	282-304	fibronectin 1	Mus musculus	103-114
8663348-3	1996	Here we report that the adhesion-dependent activation of the MAP kinase Erk2 (extracellular signal-regulated kinase 2) occurs in serum-starved NIH3T3 cells, and that this activation of Erk2 is preceded by the activation of the small GTP-binding protein Ras in fibronectin-adherent cells.	Guanosine Triphosphate	233-236	fibronectin 1	Mus musculus	260-271
9181055-0	1996	Ha-ras oncogene transformation abolishes retinoic acid-induced reduction of intracellular fibronectin.	Tretinoin	41-54	fibronectin 1	Mus musculus	90-101
9181055-2	1996	Therefore, we were interested in the effect of RA on the biosynthesis of fibronectin (FN).	Tretinoin	47-49	fibronectin 1	Mus musculus	73-84
9181055-2	1996	Therefore, we were interested in the effect of RA on the biosynthesis of fibronectin (FN).	Tretinoin	47-49	fibronectin 1	Mus musculus	86-88
9181055-3	1996	RA reduced the level of intracellular FN in a time- and concentration-dependent fashion in NIH-3T3 cells, but not in NIH-3T3 cells transformed by an activated Ha-ras oncogene.	Tretinoin	0-2	fibronectin 1	Mus musculus	38-40
9181055-7	1996	A variety of approaches permitted the following conclusions: 1) RA-dependent FN downmodulation is mediated by RARs, 2) retinoid X receptors (RXRs) mediate the observed reduction of RAR alpha by RA, and 3) the blockade of RA responsiveness by Ha-ras-transfected cells cannot be overcome by overexpression of RAR alpha.	Tretinoin	64-66	fibronectin 1	Mus musculus	77-79
9181055-8	1996	These studies have identified fibronectin and RAR alpha as RA targets in fibroblast cells and have shown that oncogenic transformation renders the cells resistant to RA action.	Tretinoin	59-61	fibronectin 1	Mus musculus	30-41
11725118-1	1996	Triflavin, an Arg-Gly-Asp (RGD)-containing snake venom peptide, inhibits B16-F10 mouse melanoma cell adhesion to extracellular matrices, e.g. fibronectin, vitronectin, fibrinogen, and collagen type I.	triflavin	0-9	fibronectin 1	Mus musculus	142-153
8866003-0	1996	Okadaic acid increases fibronectin synthesis in MC3T3-E1 cells.	Okadaic Acid	0-12	fibronectin 1	Mus musculus	23-34
8866003-2	1996	To determine whether okadaic acid affects the expression of fibronectin in MC3T3-E1 cells, we measured mRNA level and synthesis of fibronectin by Northern blot hybridization and immunoprecipitation methods, respectively.	Okadaic Acid	21-33	fibronectin 1	Mus musculus	60-71
8866003-3	1996	Okadaic acid (10-50 ng/ml) increased both mRNA level and synthesis of fibronectin in a dose-dependent manner.	Okadaic Acid	0-12	fibronectin 1	Mus musculus	70-81
8866003-4	1996	The increase of fibronectin mRNA by okadaic acid was strongly attenuated by the inhibition of new protein synthesis.	Okadaic Acid	36-48	fibronectin 1	Mus musculus	16-27
8866003-5	1996	The results indicate that okadaic acid, inhibitor of protein phosphatases, increases fibronectin synthesis in MC3T3-E1 cells.	Okadaic Acid	26-38	fibronectin 1	Mus musculus	85-96
8700540-4	1996	In oxamflatin-treated DT cells, the expression of transcription factor junD was highly augmented, resulting in trans-activation of fibronectin gene by junD via cyclic AMP responsive element in its promoter.	oxamflatin	3-13	fibronectin 1	Mus musculus	131-142
8700540-4	1996	In oxamflatin-treated DT cells, the expression of transcription factor junD was highly augmented, resulting in trans-activation of fibronectin gene by junD via cyclic AMP responsive element in its promoter.	Thymidine	22-24	fibronectin 1	Mus musculus	131-142
8700540-4	1996	In oxamflatin-treated DT cells, the expression of transcription factor junD was highly augmented, resulting in trans-activation of fibronectin gene by junD via cyclic AMP responsive element in its promoter.	Cyclic AMP	160-170	fibronectin 1	Mus musculus	131-142
8896988-13	1996	Attachment of decidual cells to FN was calcium dependent and gly-arg-gly-asp-ser-pro (GRGDSP) sensitive, with dendritic decidual cells expressing the alpha 5 and beta 1 integrin subunits.	Calcium	39-46	fibronectin 1	Mus musculus	32-34
8698481-5	1996	The inhibitory action depended on the fimbrial interaction with heparin-binding and cell attachment domains in the fibronectin structure.	Heparin	64-71	fibronectin 1	Mus musculus	115-126
8816475-5	1996	Using a tryptic phosphopeptide mapping approach, the in vivo phosphorylation of the Grb2 binding site on FAK (Tyr-925) was detected after fibronectin stimulation of NIH 3T3 cells and was constitutively phosphorylated in v-Src-transformed NIH 3T3 cells.	Tyrosine	110-113	fibronectin 1	Mus musculus	138-149
8797583-3	1996	Etoposide-induced DNA breakage was inhibited by culturing TDECs on gelatin, type IV collagen, laminin, fibronectin, and the integrin ligand hexapeptide, GRGDSP, but not the inactive peptide, GRADSP.	Etoposide	0-9	fibronectin 1	Mus musculus	103-114
8658052-9	1996	Because in the antigen-stimulated acute infection spleen or granuloma cultures the co-stimulatory effect by FN was abrogated by the tripeptide (RGD) arg-gly asp, and anti alpha 5 beta 1 antibody, enhancement is attributed to signalling via the alpha 5 beta 1 integrin receptor of lymphocytes.	tripeptide K-26	132-142	fibronectin 1	Mus musculus	108-110
8658052-9	1996	Because in the antigen-stimulated acute infection spleen or granuloma cultures the co-stimulatory effect by FN was abrogated by the tripeptide (RGD) arg-gly asp, and anti alpha 5 beta 1 antibody, enhancement is attributed to signalling via the alpha 5 beta 1 integrin receptor of lymphocytes.	Arginine	149-152	fibronectin 1	Mus musculus	108-110
8658052-9	1996	Because in the antigen-stimulated acute infection spleen or granuloma cultures the co-stimulatory effect by FN was abrogated by the tripeptide (RGD) arg-gly asp, and anti alpha 5 beta 1 antibody, enhancement is attributed to signalling via the alpha 5 beta 1 integrin receptor of lymphocytes.	Glycine	153-156	fibronectin 1	Mus musculus	108-110
8658052-9	1996	Because in the antigen-stimulated acute infection spleen or granuloma cultures the co-stimulatory effect by FN was abrogated by the tripeptide (RGD) arg-gly asp, and anti alpha 5 beta 1 antibody, enhancement is attributed to signalling via the alpha 5 beta 1 integrin receptor of lymphocytes.	Aspartic Acid	157-160	fibronectin 1	Mus musculus	108-110
8645178-1	1996	We previously reported that a mouse Lewis lung carcinoma-derived stroma-inducing clone, P29, highly expresses a syndecan-like proteoglycan exhibiting specific binding to fibronectin, a major constituent of the interstitial matrix formed by the induced stromal cells, via its heparan sulphate chains [Itano, Oguri, Nakanishi and Okayama (1993) J. Biochem.	Heparitin Sulfate	275-291	fibronectin 1	Mus musculus	170-181
8722626-7	1996	The effect of fibronectin was inhibited by hexapeptides that contained the integrin-recognizing Arg-Gly-Asp sequence.	Arginine	96-99	fibronectin 1	Mus musculus	14-25
8722626-7	1996	The effect of fibronectin was inhibited by hexapeptides that contained the integrin-recognizing Arg-Gly-Asp sequence.	Glycine	100-103	fibronectin 1	Mus musculus	14-25
8722626-7	1996	The effect of fibronectin was inhibited by hexapeptides that contained the integrin-recognizing Arg-Gly-Asp sequence.	Aspartic Acid	104-107	fibronectin 1	Mus musculus	14-25
8666673-7	1996	Purified bone marrow PMNS from wild-type mice released significant amounts of O2- when adherent to fibrinogen-, fibronectin-, or collagen-coated surfaces, in the presence of activating agents such as tumor necrosis factor (TNF) or formyl-methionyl-leucyl-phenylalanine, as described for human PMNs.	Oxygen	78-80	fibronectin 1	Mus musculus	112-123
8642440-5	1996	Specifically, 12(S)-HETE enhanced the activation of protein kinase C by phorbol esters, mimicked phorbol ester-induced adhesion of keratinocytes to fibronectin and mimicked phorbol ester repression of expression of a differentiation-related gene, keratin-1.	Phorbol Esters	97-110	fibronectin 1	Mus musculus	148-159
8626453-0	1996	Retinoic acid down-regulation of fibronectin and retinoic acid receptor alpha proteins in NIH-3T3 cells.	Tretinoin	0-13	fibronectin 1	Mus musculus	33-44
8626453-2	1996	All-trans-retinoic acid (RA) markedly reduced the level of intracellular fibronectin (FN) in a time- and concentration-dependent fashion in NIH-3T3 cells, but not in NIH-3T3 cells transformed by an activated Ha-ras oncogene.	Tretinoin	0-23	fibronectin 1	Mus musculus	73-84
8626453-2	1996	All-trans-retinoic acid (RA) markedly reduced the level of intracellular fibronectin (FN) in a time- and concentration-dependent fashion in NIH-3T3 cells, but not in NIH-3T3 cells transformed by an activated Ha-ras oncogene.	Tretinoin	0-23	fibronectin 1	Mus musculus	86-88
8626453-2	1996	All-trans-retinoic acid (RA) markedly reduced the level of intracellular fibronectin (FN) in a time- and concentration-dependent fashion in NIH-3T3 cells, but not in NIH-3T3 cells transformed by an activated Ha-ras oncogene.	Tretinoin	25-27	fibronectin 1	Mus musculus	73-84
8626453-2	1996	All-trans-retinoic acid (RA) markedly reduced the level of intracellular fibronectin (FN) in a time- and concentration-dependent fashion in NIH-3T3 cells, but not in NIH-3T3 cells transformed by an activated Ha-ras oncogene.	Tretinoin	25-27	fibronectin 1	Mus musculus	86-88
8626453-3	1996	Pulse/chase experiments indicated that RA affects FN biosynthesis rather than its turnover rate.	Tretinoin	39-41	fibronectin 1	Mus musculus	50-52
8626453-8	1996	We identified the retinoid signal transduction pathways responsible for the effects of RA on FN and RAR alpha proteins by the use of the retinoid X receptor-selective compound, SR11237, by stable over-expression of a truncated form of the RAR alpha gene, RAR alpha 403 with strong RAR dominant negative activity, and by overexpression of RAR alpha.	Retinoids	18-26	fibronectin 1	Mus musculus	93-95
9030244-1	1996	Treatment of high-metastatic Lewis lung carcinoma A11 cells with sodium orthovanadate, a phosphotyrosine phosphatase inhibitor, resulted in a dose- and time-dependent suppression of cell spreading on various extracellular matrix components such as Matrigel, fibronectin, laminin and type IV collagen, while the treatment did not significantly inhibit attachment of the cells to these substrates.	Sodium orthovanadate	65-85	fibronectin 1	Mus musculus	258-269
8604318-3	1996	Phosphorothioate oligodeoxynucleotides bind to the extracellular matrix (ECM) of NIH 3T3 cells, and to the ECM elements laminin and fibronectin.	Parathion	0-16	fibronectin 1	Mus musculus	132-143
8604318-3	1996	Phosphorothioate oligodeoxynucleotides bind to the extracellular matrix (ECM) of NIH 3T3 cells, and to the ECM elements laminin and fibronectin.	Oligodeoxyribonucleotides	17-38	fibronectin 1	Mus musculus	132-143
8681349-9	1996	The fibronectin and type I collagen depositions in pre-migratory outflow tract cardiac jelly in retinoic acid-treated embryonic heart were reduced compared to those in the control.	Tretinoin	96-109	fibronectin 1	Mus musculus	4-15
8573179-4	1996	Treatment with monoclonal antibodies specifically reactive with albumin modified by Amadori glucose adducts normalized fibronectin in diabetic animals despite persistent hyperglycemia.	Glucose	92-99	fibronectin 1	Mus musculus	119-130
8979267-0	1996	Inhibition of tumor invasion and metastasis by peptidic mimetics of Arg-Gly Asp (RGD) derived from the cell recognition site of fibronectin.	arginyl-glycyl-aspartic acid	68-79	fibronectin 1	Mus musculus	128-139
8979267-1	1996	The partially modified retro- and retro-inverso peptides of the Arg-Gly Asp (RGD) sequence of fibronectin, in which the direction of the Arg residue is reversed and/or the chirality of the amino acid residue is inverted, i.e., mainly R(rev)-COCH2CO-D and DR(rev)-COCH2CO-D, have been synthesized to examine their antimetastatic effects in murine lung or liver metastasis models, as well as their inhibitory effect on tumor cell invasion in vitro.	Arginine	64-67	fibronectin 1	Mus musculus	94-105
8979267-1	1996	The partially modified retro- and retro-inverso peptides of the Arg-Gly Asp (RGD) sequence of fibronectin, in which the direction of the Arg residue is reversed and/or the chirality of the amino acid residue is inverted, i.e., mainly R(rev)-COCH2CO-D and DR(rev)-COCH2CO-D, have been synthesized to examine their antimetastatic effects in murine lung or liver metastasis models, as well as their inhibitory effect on tumor cell invasion in vitro.	Glycine	68-71	fibronectin 1	Mus musculus	94-105
8582015-2	1995	Preparation of fibronectin-related peptide poly(ethylene glycol) hybrids and their inhibitory effect on experimental metastasis.	Polyethylene Glycols	43-64	fibronectin 1	Mus musculus	15-26
8582015-3	1995	Hybrids of fibronectin-related peptides [Arg-Gly-Asp (RGD), Arg-Gly-Asp-Ser (RGDS)] and poly(ethylene glycol) (PEG) were prepared and their inhibitory effects on experimental metastasis in mice were examined.	arginyl-glycyl-aspartic acid	41-52	fibronectin 1	Mus musculus	11-22
8582015-3	1995	Hybrids of fibronectin-related peptides [Arg-Gly-Asp (RGD), Arg-Gly-Asp-Ser (RGDS)] and poly(ethylene glycol) (PEG) were prepared and their inhibitory effects on experimental metastasis in mice were examined.	arginyl-glycyl-aspartyl-serine	60-75	fibronectin 1	Mus musculus	11-22
8582015-3	1995	Hybrids of fibronectin-related peptides [Arg-Gly-Asp (RGD), Arg-Gly-Asp-Ser (RGDS)] and poly(ethylene glycol) (PEG) were prepared and their inhibitory effects on experimental metastasis in mice were examined.	Polyethylene Glycols	88-109	fibronectin 1	Mus musculus	11-22
7589452-2	1995	Inhibitors of protein tyrosine kinases, methyl 2,5-dihydroxycinnamate and herbimycin A, inhibited tyrosine-phosphorylation of FAK and the adhesion of 3T3 cells to fibronectin.	methyl 2,5-dihydroxycinnamate	40-69	fibronectin 1	Mus musculus	163-174
7589452-2	1995	Inhibitors of protein tyrosine kinases, methyl 2,5-dihydroxycinnamate and herbimycin A, inhibited tyrosine-phosphorylation of FAK and the adhesion of 3T3 cells to fibronectin.	herbimycin	74-86	fibronectin 1	Mus musculus	163-174
7589452-2	1995	Inhibitors of protein tyrosine kinases, methyl 2,5-dihydroxycinnamate and herbimycin A, inhibited tyrosine-phosphorylation of FAK and the adhesion of 3T3 cells to fibronectin.	Tyrosine	22-30	fibronectin 1	Mus musculus	163-174
8612967-5	1995	Brefeldin A treatment of an organotypic slice preparation demonstrates FN production in the intermediate zone and cortical plate, in locations that correspond exactly to the distribution of FN mRNA by in situ hybridization.	Brefeldin A	0-11	fibronectin 1	Mus musculus	71-73
8612967-5	1995	Brefeldin A treatment of an organotypic slice preparation demonstrates FN production in the intermediate zone and cortical plate, in locations that correspond exactly to the distribution of FN mRNA by in situ hybridization.	Brefeldin A	0-11	fibronectin 1	Mus musculus	190-192
8612967-8	1995	Examination of dissociated cortical cells by laser confocal microscopy confirms that FN accumulation after brefeldin A treatment is intracellular in neurons as well as in glia.	Brefeldin A	107-118	fibronectin 1	Mus musculus	85-87
7593207-0	1995	Melanoma cell spreading on fibronectin induced by 12(S)-HETE involves both protein kinase C- and protein tyrosine kinase-dependent focal adhesion formation and tyrosine phosphorylation of focal adhesion kinase (pp125FAK).	Tyrosine	105-113	fibronectin 1	Mus musculus	27-38
7593207-1	1995	Our previous work demonstrated that 12(S)-HETE, a lipoxygenase metabolite of arachidonic acid, promoted B16 amelanotic melanoma (B16a) cell spreading on fibronectin.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	36-46	fibronectin 1	Mus musculus	153-164
7593207-1	1995	Our previous work demonstrated that 12(S)-HETE, a lipoxygenase metabolite of arachidonic acid, promoted B16 amelanotic melanoma (B16a) cell spreading on fibronectin.	Arachidonic Acid	77-93	fibronectin 1	Mus musculus	153-164
7593207-3	1995	12(S)-HETE treatment resulted in a time-dependent increase in B16a cell spreading on fibronectin, which was blocked by either calphostin C or by genistein but not by H8.	calphostin C	126-138	fibronectin 1	Mus musculus	85-96
7593207-3	1995	12(S)-HETE treatment resulted in a time-dependent increase in B16a cell spreading on fibronectin, which was blocked by either calphostin C or by genistein but not by H8.	Genistein	145-154	fibronectin 1	Mus musculus	85-96
7593207-12	1995	The present study suggests that 12(S)-HETE promoted melanoma cell spreading on fibronectin involves tyrosine phosphorylation of pp125FAK and protein kinase C- and tyrosine kinase-dependent focal adhesion formation.	Hydroxyeicosatetraenoic Acids	34-42	fibronectin 1	Mus musculus	79-90
7593207-12	1995	The present study suggests that 12(S)-HETE promoted melanoma cell spreading on fibronectin involves tyrosine phosphorylation of pp125FAK and protein kinase C- and tyrosine kinase-dependent focal adhesion formation.	Tyrosine	100-108	fibronectin 1	Mus musculus	79-90
8979267-1	1996	The partially modified retro- and retro-inverso peptides of the Arg-Gly Asp (RGD) sequence of fibronectin, in which the direction of the Arg residue is reversed and/or the chirality of the amino acid residue is inverted, i.e., mainly R(rev)-COCH2CO-D and DR(rev)-COCH2CO-D, have been synthesized to examine their antimetastatic effects in murine lung or liver metastasis models, as well as their inhibitory effect on tumor cell invasion in vitro.	Aspartic Acid	72-75	fibronectin 1	Mus musculus	94-105
8979267-1	1996	The partially modified retro- and retro-inverso peptides of the Arg-Gly Asp (RGD) sequence of fibronectin, in which the direction of the Arg residue is reversed and/or the chirality of the amino acid residue is inverted, i.e., mainly R(rev)-COCH2CO-D and DR(rev)-COCH2CO-D, have been synthesized to examine their antimetastatic effects in murine lung or liver metastasis models, as well as their inhibitory effect on tumor cell invasion in vitro.	Arginine	137-140	fibronectin 1	Mus musculus	94-105
7612963-6	1995	Cytochalasin D blocked the activation of MAP kinase activity that was induced by the binding of cells to fibronectin.	Cytochalasin D	0-14	fibronectin 1	Mus musculus	105-116
8583506-8	1995	Long-term ethanol exposure also inhibited attachment to other substrata, including laminin, fibronectin and vitronectin.	Ethanol	10-17	fibronectin 1	Mus musculus	92-103
7548227-6	1995	It was also shown that N-3554S treatment enhances the adhesiveness of the cells to fibronectin.	dihydrodecaprenyl phosphate	23-30	fibronectin 1	Mus musculus	83-94
8845804-2	1995	In an in vitro analysis, both saponin preparations showed a significant inhibition of adhesion to fibronectin (FN) and laminin (LM) by B16-BL6 melanoma.	Saponins	30-37	fibronectin 1	Mus musculus	98-109
8845804-2	1995	In an in vitro analysis, both saponin preparations showed a significant inhibition of adhesion to fibronectin (FN) and laminin (LM) by B16-BL6 melanoma.	Saponins	30-37	fibronectin 1	Mus musculus	111-113
7635568-6	1995	Light and electron microscopic studies and immunocytochemistry showed that 10(-8) M 1,25-(OH)2D3 induced morphological changes in C116 spheroids, with a marked reduction in expression of fibronectin, laminin and the gap junction protein connexin 43.	Calcitriol	84-96	fibronectin 1	Mus musculus	187-198
7576611-3	1995	A 40 kD COOH-terminal chymotryptic fragment of fibronectin containing both a heparin-binding region and an alternate (non-RGD) cell-binding site was inactive in supporting trophoblast adhesion.	Heparin	77-84	fibronectin 1	Mus musculus	47-58
7576611-5	1995	A 75 kD recombinant protein, ProNectin F, containing 13 copies of the cell recognition epitope of fibronectin, Val-Thr-Gly-Arg-Gly-Asp-Ser-Pro-Ala-Ser, vigorously supported blastocyst outgrowth.	Glycine	119-122	fibronectin 1	Mus musculus	98-109
7576611-5	1995	A 75 kD recombinant protein, ProNectin F, containing 13 copies of the cell recognition epitope of fibronectin, Val-Thr-Gly-Arg-Gly-Asp-Ser-Pro-Ala-Ser, vigorously supported blastocyst outgrowth.	Arginine	123-126	fibronectin 1	Mus musculus	98-109
7593175-5	1995	Coating of fibronectin on the culture dish prevented both NH2Cl-induced peeling off and a decrease in p-Tyr content.	chloramine	58-63	fibronectin 1	Mus musculus	11-22
7593175-5	1995	Coating of fibronectin on the culture dish prevented both NH2Cl-induced peeling off and a decrease in p-Tyr content.	Phosphotyrosine	102-107	fibronectin 1	Mus musculus	11-22
7550111-4	1995	Similar enhancement was observed when the macrophages were plated on a substrate pre-coated with Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) peptide, an adhesive sequence of FN involved in binding to the cells, but not with the control Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) peptide.	Glycyl-Arginine	97-104	fibronectin 1	Mus musculus	163-165
7550111-4	1995	Similar enhancement was observed when the macrophages were plated on a substrate pre-coated with Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) peptide, an adhesive sequence of FN involved in binding to the cells, but not with the control Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) peptide.	Glycine	97-100	fibronectin 1	Mus musculus	163-165
7550111-4	1995	Similar enhancement was observed when the macrophages were plated on a substrate pre-coated with Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) peptide, an adhesive sequence of FN involved in binding to the cells, but not with the control Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) peptide.	Aspartic Acid	109-112	fibronectin 1	Mus musculus	163-165
7550111-4	1995	Similar enhancement was observed when the macrophages were plated on a substrate pre-coated with Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) peptide, an adhesive sequence of FN involved in binding to the cells, but not with the control Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) peptide.	Serine	113-116	fibronectin 1	Mus musculus	163-165
7550111-4	1995	Similar enhancement was observed when the macrophages were plated on a substrate pre-coated with Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) peptide, an adhesive sequence of FN involved in binding to the cells, but not with the control Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) peptide.	Glycine	105-108	fibronectin 1	Mus musculus	163-165
7550111-4	1995	Similar enhancement was observed when the macrophages were plated on a substrate pre-coated with Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) peptide, an adhesive sequence of FN involved in binding to the cells, but not with the control Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) peptide.	Arginine	101-104	fibronectin 1	Mus musculus	163-165
7550111-4	1995	Similar enhancement was observed when the macrophages were plated on a substrate pre-coated with Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) peptide, an adhesive sequence of FN involved in binding to the cells, but not with the control Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) peptide.	Glycine	105-108	fibronectin 1	Mus musculus	163-165
7550111-4	1995	Similar enhancement was observed when the macrophages were plated on a substrate pre-coated with Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) peptide, an adhesive sequence of FN involved in binding to the cells, but not with the control Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) peptide.	Glutamic Acid	237-240	fibronectin 1	Mus musculus	163-165
7550111-4	1995	Similar enhancement was observed when the macrophages were plated on a substrate pre-coated with Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) peptide, an adhesive sequence of FN involved in binding to the cells, but not with the control Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) peptide.	Serine	241-244	fibronectin 1	Mus musculus	163-165
7750488-1	1995	The role of progesterone in FSH- and 8-bromo-cAMP (8-Br-cAMP)-induced fibronectin production by chicken ovarian granulosa cells was examined.	8-Bromo Cyclic Adenosine Monophosphate	37-49	fibronectin 1	Mus musculus	70-81
7750488-1	1995	The role of progesterone in FSH- and 8-bromo-cAMP (8-Br-cAMP)-induced fibronectin production by chicken ovarian granulosa cells was examined.	8-Bromo Cyclic Adenosine Monophosphate	51-60	fibronectin 1	Mus musculus	70-81
7750488-4	1995	FSH or 8-Br-cAMP significantly increased fibronectin deposition.	8-Bromo Cyclic Adenosine Monophosphate	7-16	fibronectin 1	Mus musculus	41-52
7750488-6	1995	The magnitude of FSH- and 8-Br-cAMP-enhanced fibronectin deposition or secretion into medium by SYF cells was greater than that by F3 cells.	8-br	26-30	fibronectin 1	Mus musculus	45-56
7750488-6	1995	The magnitude of FSH- and 8-Br-cAMP-enhanced fibronectin deposition or secretion into medium by SYF cells was greater than that by F3 cells.	Cyclic AMP	31-35	fibronectin 1	Mus musculus	45-56
7750488-7	1995	Cyanoketone (an inhibitor of progesterone synthesis) significantly suppressed basal fibronectin production by F3 cells, but not that by SYF cells.	Cyanoketone	0-11	fibronectin 1	Mus musculus	84-95
7750488-8	1995	Cyanoketone completely blocked FSH- or 8-Br-cAMP-induced fibronectin production by F3 cells, but caused only a modest inhibition (nonsignificant) of agonist-induced fibronectin production by SYF cells.	Cyanoketone	0-11	fibronectin 1	Mus musculus	57-68
7750488-8	1995	Cyanoketone completely blocked FSH- or 8-Br-cAMP-induced fibronectin production by F3 cells, but caused only a modest inhibition (nonsignificant) of agonist-induced fibronectin production by SYF cells.	Cyanoketone	0-11	fibronectin 1	Mus musculus	165-176
7750488-8	1995	Cyanoketone completely blocked FSH- or 8-Br-cAMP-induced fibronectin production by F3 cells, but caused only a modest inhibition (nonsignificant) of agonist-induced fibronectin production by SYF cells.	8-br	39-43	fibronectin 1	Mus musculus	57-68
7750488-8	1995	Cyanoketone completely blocked FSH- or 8-Br-cAMP-induced fibronectin production by F3 cells, but caused only a modest inhibition (nonsignificant) of agonist-induced fibronectin production by SYF cells.	Cyclic AMP	44-48	fibronectin 1	Mus musculus	57-68
7750488-9	1995	Exogenous progesterone completely reversed the inhibitory effects of cyanoketone on agonist-induced fibronectin production.	Progesterone	10-22	fibronectin 1	Mus musculus	100-111
7750488-9	1995	Exogenous progesterone completely reversed the inhibitory effects of cyanoketone on agonist-induced fibronectin production.	Cyanoketone	69-80	fibronectin 1	Mus musculus	100-111
7750488-10	1995	The nondegradable synthetic progestin R5020 also reversed the inhibitory effects of cyanoketone on agonist-induced fibronectin production.	Promegestone	38-43	fibronectin 1	Mus musculus	115-126
7750488-10	1995	The nondegradable synthetic progestin R5020 also reversed the inhibitory effects of cyanoketone on agonist-induced fibronectin production.	Cyanoketone	84-95	fibronectin 1	Mus musculus	115-126
7750488-12	1995	The data demonstrate that FSH- and cAMP-stimulated fibronectin production by chicken granulosa cells is dependent (at least in part) on de novo progesterone synthesis.	Cyclic AMP	35-39	fibronectin 1	Mus musculus	51-62
7750488-12	1995	The data demonstrate that FSH- and cAMP-stimulated fibronectin production by chicken granulosa cells is dependent (at least in part) on de novo progesterone synthesis.	de novo progesterone	136-156	fibronectin 1	Mus musculus	51-62
7750488-13	1995	Furthermore, they indicate that fibronectin production and deposition by these cells are stimulated by progesterone, perhaps in an intracrine/autocrine manner, and that the role of progesterone increases with advancing stages of follicular development.	Progesterone	103-115	fibronectin 1	Mus musculus	32-43
7538116-6	1995	Soluble fibronectin (IC50 = 0.2 microM) or Gly-Arg-Gly-Asp-Ser-Pro, but not laminin, competitively inhibited fibronectin binding activity.	glycyl-arginyl-glycyl-aspartyl-seryl-proline	43-66	fibronectin 1	Mus musculus	109-120
7583009-7	1995	We investigated phosphotyrosine levels in response to adhesion to fibronectin and identified the pp60src substrate p130 as the one major protein with reduced levels of tyrosine phosphorylation in the cells lacking p59fyn and pp62c-yes, and particularly in those lacking pp60c-src.	Phosphotyrosine	16-31	fibronectin 1	Mus musculus	66-77
7583009-7	1995	We investigated phosphotyrosine levels in response to adhesion to fibronectin and identified the pp60src substrate p130 as the one major protein with reduced levels of tyrosine phosphorylation in the cells lacking p59fyn and pp62c-yes, and particularly in those lacking pp60c-src.	Tyrosine	23-31	fibronectin 1	Mus musculus	66-77
7537699-3	1995	The adhesion of a-EAT cells to laminin or fibronectin requires the presence of both Ca2+ and Mg2+.	magnesium ion	93-97	fibronectin 1	Mus musculus	42-53
7779998-3	1995	The results demonstrated that 1) in these blastocysts, contact of EPC cells with fibronectin-coated glass substratum in the presence of FBS triggered an outburst of cell proliferation with the eventual differentiation of the EPC cells into secondary giant trophoblast cells and 2) frequencies of blastocysts that exhibited EPC cell proliferation significantly increased if FO medium (modified Eagle"s minimum essential medium) was supplemented with FBS depleted of heparin-binding substances (H-FBS).	fo	373-375	fibronectin 1	Mus musculus	81-92
7779998-3	1995	The results demonstrated that 1) in these blastocysts, contact of EPC cells with fibronectin-coated glass substratum in the presence of FBS triggered an outburst of cell proliferation with the eventual differentiation of the EPC cells into secondary giant trophoblast cells and 2) frequencies of blastocysts that exhibited EPC cell proliferation significantly increased if FO medium (modified Eagle"s minimum essential medium) was supplemented with FBS depleted of heparin-binding substances (H-FBS).	eagle"s minimum essential medium	393-425	fibronectin 1	Mus musculus	81-92
7779998-3	1995	The results demonstrated that 1) in these blastocysts, contact of EPC cells with fibronectin-coated glass substratum in the presence of FBS triggered an outburst of cell proliferation with the eventual differentiation of the EPC cells into secondary giant trophoblast cells and 2) frequencies of blastocysts that exhibited EPC cell proliferation significantly increased if FO medium (modified Eagle"s minimum essential medium) was supplemented with FBS depleted of heparin-binding substances (H-FBS).	Heparin	465-472	fibronectin 1	Mus musculus	81-92
7542253-7	1995	GRGDS (gly-arg-gly-asp-ser) peptides inhibited cell adhesion to intact GST-OPN, as well as to fibronectin and vitronectin.	Glycine	7-10	fibronectin 1	Mus musculus	94-105
7542253-7	1995	GRGDS (gly-arg-gly-asp-ser) peptides inhibited cell adhesion to intact GST-OPN, as well as to fibronectin and vitronectin.	Arginine	11-14	fibronectin 1	Mus musculus	94-105
7542253-7	1995	GRGDS (gly-arg-gly-asp-ser) peptides inhibited cell adhesion to intact GST-OPN, as well as to fibronectin and vitronectin.	Glycine	15-18	fibronectin 1	Mus musculus	94-105
7542253-7	1995	GRGDS (gly-arg-gly-asp-ser) peptides inhibited cell adhesion to intact GST-OPN, as well as to fibronectin and vitronectin.	Aspartic Acid	19-22	fibronectin 1	Mus musculus	94-105
7542253-7	1995	GRGDS (gly-arg-gly-asp-ser) peptides inhibited cell adhesion to intact GST-OPN, as well as to fibronectin and vitronectin.	Serine	23-26	fibronectin 1	Mus musculus	94-105
7706770-0	1995	Topical tretinoin increases the tropoelastin and fibronectin content of photoaged hairless mouse skin.	Tretinoin	8-17	fibronectin 1	Mus musculus	49-60
7706770-6	1995	The distribution of elastin and fibronectin was examined by immunofluorescence microscopy, which revealed fine fibrils in the subepidermal zone in tretinoin-treated skin.	Tretinoin	147-156	fibronectin 1	Mus musculus	32-43
7532131-4	1995	Substitution of tyrosine 719 in the kinase insert with phenylalanine (Y719F) abolished PI3-kinase activation, diminished c-fos and junB induction, and impaired KL-induced adhesion of BMMC to fibronectin.	Tyrosine	16-24	fibronectin 1	Mus musculus	191-202
7532131-4	1995	Substitution of tyrosine 719 in the kinase insert with phenylalanine (Y719F) abolished PI3-kinase activation, diminished c-fos and junB induction, and impaired KL-induced adhesion of BMMC to fibronectin.	Phenylalanine	55-68	fibronectin 1	Mus musculus	191-202
7540635-6	1995	We now report that the Arg-Gly-Asp-mimetics specifically inhibited the binding of murine T cells to fibronectin, but did not affect the proliferative response of these cells in vitro.	Arginine	23-26	fibronectin 1	Mus musculus	100-111
7540635-6	1995	We now report that the Arg-Gly-Asp-mimetics specifically inhibited the binding of murine T cells to fibronectin, but did not affect the proliferative response of these cells in vitro.	Glycine	27-30	fibronectin 1	Mus musculus	100-111
7540635-6	1995	We now report that the Arg-Gly-Asp-mimetics specifically inhibited the binding of murine T cells to fibronectin, but did not affect the proliferative response of these cells in vitro.	Aspartic Acid	31-34	fibronectin 1	Mus musculus	100-111
7962129-1	1994	Results of previous studies show that the expression of fibronectin and its cell-surface fibronectin binding receptor is coregulated in 3-methylchloranthrene transformation of normal AKR-2B cells to form AKR-MCA cells and in N,N,-dimethylformamide (DMF) induction of differentiation of transformed AKR-MCA cells (1990, J.	3-methylchloranthrene	136-157	fibronectin 1	Mus musculus	56-67
7735124-5	1995	Native echistatin was also able to inhibit B16-BL6 cell attachment to IgG antihuman fibronectin receptor-coated wells, thus suggesting that the molecule binds to adhesive receptors on melanoma cell surface.	echistatin	7-17	fibronectin 1	Mus musculus	84-95
7820952-3	1995	Sublethal oxidative stress generated by exposure of cells to hydrogen peroxide (H2O2, 1-1000 microM/L) inhibited tumor cell attachment to immobilized laminin or fibronectin.	Hydrogen Peroxide	61-78	fibronectin 1	Mus musculus	161-172
7820952-3	1995	Sublethal oxidative stress generated by exposure of cells to hydrogen peroxide (H2O2, 1-1000 microM/L) inhibited tumor cell attachment to immobilized laminin or fibronectin.	Hydrogen Peroxide	80-84	fibronectin 1	Mus musculus	161-172
7533313-7	1995	Immunoblot analysis demonstrated that, among the proteins, laminin and fibronectin were found exclusively in the guanidine and guanidine/dithiotreitol extracts.	Guanidine	113-122	fibronectin 1	Mus musculus	71-82
7533313-7	1995	Immunoblot analysis demonstrated that, among the proteins, laminin and fibronectin were found exclusively in the guanidine and guanidine/dithiotreitol extracts.	Guanidine	127-136	fibronectin 1	Mus musculus	71-82
7533313-7	1995	Immunoblot analysis demonstrated that, among the proteins, laminin and fibronectin were found exclusively in the guanidine and guanidine/dithiotreitol extracts.	Dithiothreitol	137-150	fibronectin 1	Mus musculus	71-82
7957710-6	1994	We observed that the majority of primitive CAFC-28/35 adhered to fibronectin, while only a minority of CFU-S-like CAFC-10 did.	cafc	43-47	fibronectin 1	Mus musculus	65-76
7957710-7	1994	The adherence of primitive stem cells to fibronectin could partially be blocked by high molar concentrations of oligopeptides containing the essential amino acid sequence of the central cell-binding domain of fibronectin, RGD.	Amino Acids, Essential	141-161	fibronectin 1	Mus musculus	41-52
7957710-7	1994	The adherence of primitive stem cells to fibronectin could partially be blocked by high molar concentrations of oligopeptides containing the essential amino acid sequence of the central cell-binding domain of fibronectin, RGD.	Amino Acids, Essential	141-161	fibronectin 1	Mus musculus	209-220
7957710-8	1994	Adherence of the small subpopulation of CAFC-10 to fibronectin could almost entirely be prevented by oligopeptides organized in a specific fashion.	cafc-10	40-47	fibronectin 1	Mus musculus	51-62
7962129-1	1994	Results of previous studies show that the expression of fibronectin and its cell-surface fibronectin binding receptor is coregulated in 3-methylchloranthrene transformation of normal AKR-2B cells to form AKR-MCA cells and in N,N,-dimethylformamide (DMF) induction of differentiation of transformed AKR-MCA cells (1990, J.	Dimethylformamide	225-247	fibronectin 1	Mus musculus	56-67
7962129-1	1994	Results of previous studies show that the expression of fibronectin and its cell-surface fibronectin binding receptor is coregulated in 3-methylchloranthrene transformation of normal AKR-2B cells to form AKR-MCA cells and in N,N,-dimethylformamide (DMF) induction of differentiation of transformed AKR-MCA cells (1990, J.	Dimethylformamide	225-247	fibronectin 1	Mus musculus	89-100
7962129-1	1994	Results of previous studies show that the expression of fibronectin and its cell-surface fibronectin binding receptor is coregulated in 3-methylchloranthrene transformation of normal AKR-2B cells to form AKR-MCA cells and in N,N,-dimethylformamide (DMF) induction of differentiation of transformed AKR-MCA cells (1990, J.	Dimethylformamide	249-252	fibronectin 1	Mus musculus	56-67
7962129-1	1994	Results of previous studies show that the expression of fibronectin and its cell-surface fibronectin binding receptor is coregulated in 3-methylchloranthrene transformation of normal AKR-2B cells to form AKR-MCA cells and in N,N,-dimethylformamide (DMF) induction of differentiation of transformed AKR-MCA cells (1990, J.	Dimethylformamide	249-252	fibronectin 1	Mus musculus	89-100
7962129-9	1994	Expression of antisense fibronectin RNA in AKR-MCA cells down-modulated the ability of DMF to restore normal fibronectin production, cell-surface fibronectin binding receptor, adhesion to extracellular fibronectin, and cellular morphology.	Dimethylformamide	87-90	fibronectin 1	Mus musculus	24-35
7962129-9	1994	Expression of antisense fibronectin RNA in AKR-MCA cells down-modulated the ability of DMF to restore normal fibronectin production, cell-surface fibronectin binding receptor, adhesion to extracellular fibronectin, and cellular morphology.	Dimethylformamide	87-90	fibronectin 1	Mus musculus	109-120
7962129-9	1994	Expression of antisense fibronectin RNA in AKR-MCA cells down-modulated the ability of DMF to restore normal fibronectin production, cell-surface fibronectin binding receptor, adhesion to extracellular fibronectin, and cellular morphology.	Dimethylformamide	87-90	fibronectin 1	Mus musculus	109-120
7962129-9	1994	Expression of antisense fibronectin RNA in AKR-MCA cells down-modulated the ability of DMF to restore normal fibronectin production, cell-surface fibronectin binding receptor, adhesion to extracellular fibronectin, and cellular morphology.	Dimethylformamide	87-90	fibronectin 1	Mus musculus	109-120
7537125-7	1994	External calcium ion and temperature dependence of adhesion together with the observation that RGD (Arg, Gly, Asp)--containing peptide blocked cell binding to FN suggests that FC epsilon RI crosslinking-induced adhesion potentiation involves an integrin type receptor on cell surface.	Arginine	100-103	fibronectin 1	Mus musculus	159-161
7537125-7	1994	External calcium ion and temperature dependence of adhesion together with the observation that RGD (Arg, Gly, Asp)--containing peptide blocked cell binding to FN suggests that FC epsilon RI crosslinking-induced adhesion potentiation involves an integrin type receptor on cell surface.	Glycine	105-108	fibronectin 1	Mus musculus	159-161
7537125-7	1994	External calcium ion and temperature dependence of adhesion together with the observation that RGD (Arg, Gly, Asp)--containing peptide blocked cell binding to FN suggests that FC epsilon RI crosslinking-induced adhesion potentiation involves an integrin type receptor on cell surface.	Aspartic Acid	110-113	fibronectin 1	Mus musculus	159-161
7972695-6	1994	We then determined that radiation-enhanced expression of alpha IIb beta 3 integrin and adhesion of B16 melanoma cells to fibronectin in vitro and metastasis in vivo were reduced by treatment of the cells with the lipoxygenase inhibitor NDGA prior to irradiation.	Masoprocol	236-240	fibronectin 1	Mus musculus	121-132
8062907-0	1994	Stimulation of tyrosine- and serine-phosphorylation of focal adhesion kinase in mouse 3T3 cells by fibronectin and fibroblast growth factor.	Tyrosine	15-23	fibronectin 1	Mus musculus	99-110
8062907-0	1994	Stimulation of tyrosine- and serine-phosphorylation of focal adhesion kinase in mouse 3T3 cells by fibronectin and fibroblast growth factor.	Serine	29-35	fibronectin 1	Mus musculus	99-110
7833248-1	1995	Haemopoietic progenitor cells (HPC) synthesize and accumulate a single type of membrane-associated chondroitin sulphate proteoglycan (MA-PG), which participates in HPC adhesiveness to fibronectin by interacting with its heparin-binding domain.	Chondroitin Sulfates	99-119	fibronectin 1	Mus musculus	184-195
7833248-6	1995	Cell adhesion studies to dishes coated with the fibronectin 40 kD fragment, containing the heparin-binding domain, demonstrated that adhesiveness of IL-3-treated cells was higher than that of untreated cells.	Heparin	91-98	fibronectin 1	Mus musculus	48-59
7833248-7	1995	These results suggest that in multipotent haemopoietic cells IL-3 regulates the amount of membrane-associated proteoglycans, which in turn modify the adhesive interactions of cells with the heparin-binding domain of fibronectin.	Heparin	190-197	fibronectin 1	Mus musculus	216-227
7997267-2	1994	Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin.	Tyrosine	14-22	fibronectin 1	Mus musculus	76-87
7997267-8	1994	Phosphorylation of FAK at Tyr 925 upon fibronectin stimulation creates an SH2-binding site for GRB2 which may link integrin engagement to the activation of the Ras/MAPK signal transduction pathway.	Tyrosine	26-29	fibronectin 1	Mus musculus	39-50
7946383-7	1994	Fibronectin levels were elevated in asbestos-exposed athymic mice when compared with air-exposed athymic mice or asbestos-exposed immunocompetent mice.	Asbestos	36-44	fibronectin 1	Mus musculus	0-11
7946383-7	1994	Fibronectin levels were elevated in asbestos-exposed athymic mice when compared with air-exposed athymic mice or asbestos-exposed immunocompetent mice.	Asbestos	113-121	fibronectin 1	Mus musculus	0-11
7962129-1	1994	Results of previous studies show that the expression of fibronectin and its cell-surface fibronectin binding receptor is coregulated in 3-methylchloranthrene transformation of normal AKR-2B cells to form AKR-MCA cells and in N,N,-dimethylformamide (DMF) induction of differentiation of transformed AKR-MCA cells (1990, J.	3-methylchloranthrene	136-157	fibronectin 1	Mus musculus	89-100
8038207-0	1994	Forskolin induces the reorganization of extracellular matrix fibronectin and cytoarchitecture in 3T3-F442A adipocytes: its effect on fibronectin gene expression.	Colforsin	0-9	fibronectin 1	Mus musculus	61-72
8038207-0	1994	Forskolin induces the reorganization of extracellular matrix fibronectin and cytoarchitecture in 3T3-F442A adipocytes: its effect on fibronectin gene expression.	Colforsin	0-9	fibronectin 1	Mus musculus	133-144
8038207-1	1994	We studied the effect of forskolin on fibronectin and actin gene expression in 3T3-F442A adipogenic cell line.	Colforsin	25-34	fibronectin 1	Mus musculus	38-49
8038207-3	1994	Immunofluorescence experiments showed that preadipocytes treated for 48 h with 10 microM forskolin exhibited an intensified network of both actin and fibronectin when compared to control.	Colforsin	89-98	fibronectin 1	Mus musculus	150-161
8038207-6	1994	A parallel increase of fibronectin mRNA content was observed in forskolin-treated cells.	Colforsin	64-73	fibronectin 1	Mus musculus	23-34
8038207-8	1994	Nuclear run-on experiments showed that forskolin increased the fibronectin gene transcription rate but left that of the actin gene in adipocytes unchanged.	Colforsin	39-48	fibronectin 1	Mus musculus	63-74
8038207-9	1994	These findings suggest the reorganization of the actin network in forskolin-treated adipocytes to be a consequence of fibronectin-enhanced biosynthesis and reorganization.	Colforsin	66-75	fibronectin 1	Mus musculus	118-129
8197206-3	1994	Incubation of TGF-beta 1 (-/-) MNLs with selected synthetic peptides corresponding to cell- and heparin-binding sequences of fibronectin (FN) significantly attenuated adhesion of these cells not only to FN but also to endothelial cells in vitro.	Peptides	60-68	fibronectin 1	Mus musculus	125-136
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Serine	100-103	fibronectin 1	Mus musculus	336-347
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Aspartic Acid	104-107	fibronectin 1	Mus musculus	336-347
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Lysine	108-111	fibronectin 1	Mus musculus	336-347
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Tyrosine	112-115	fibronectin 1	Mus musculus	336-347
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Phenylalanine	116-119	fibronectin 1	Mus musculus	336-347
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Histidine	120-123	fibronectin 1	Mus musculus	336-347
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Alanine	124-127	fibronectin 1	Mus musculus	336-347
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Arginine	128-131	fibronectin 1	Mus musculus	336-347
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Glycine	132-135	fibronectin 1	Mus musculus	336-347
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Tyrosine	112-115	fibronectin 1	Mus musculus	336-347
8197206-3	1994	Incubation of TGF-beta 1 (-/-) MNLs with selected synthetic peptides corresponding to cell- and heparin-binding sequences of fibronectin (FN) significantly attenuated adhesion of these cells not only to FN but also to endothelial cells in vitro.	Peptides	60-68	fibronectin 1	Mus musculus	138-140
8197206-3	1994	Incubation of TGF-beta 1 (-/-) MNLs with selected synthetic peptides corresponding to cell- and heparin-binding sequences of fibronectin (FN) significantly attenuated adhesion of these cells not only to FN but also to endothelial cells in vitro.	Peptides	60-68	fibronectin 1	Mus musculus	203-205
8200066-0	1994	Retinoic acid and beta-carotene inhibit fibronectin synthesis and release by fibroblasts; antagonism to phorbol ester.	Tretinoin	0-13	fibronectin 1	Mus musculus	40-51
8200066-0	1994	Retinoic acid and beta-carotene inhibit fibronectin synthesis and release by fibroblasts; antagonism to phorbol ester.	beta Carotene	18-31	fibronectin 1	Mus musculus	40-51
8200066-0	1994	Retinoic acid and beta-carotene inhibit fibronectin synthesis and release by fibroblasts; antagonism to phorbol ester.	Phorbol Esters	104-117	fibronectin 1	Mus musculus	40-51
8200066-2	1994	We have now studied the action of RA and carotenoids on FN synthesis and release.	Tretinoin	34-36	fibronectin 1	Mus musculus	56-58
8200066-2	1994	We have now studied the action of RA and carotenoids on FN synthesis and release.	Carotenoids	41-52	fibronectin 1	Mus musculus	56-58
8200066-3	1994	Using mouse fibroblasts (C3H/10T1/2 cells), we found that RA inhibited release of FN into the medium in a time- and concentration-dependent manner (e.g. 90% inhibition in 48 h with 1 x 10(-6) M RA).	Tretinoin	58-60	fibronectin 1	Mus musculus	82-84
8200066-4	1994	RA caused inhibition of synthesis, as well as a time- and concentration-dependent decrease in FN mRNA.	Tretinoin	0-2	fibronectin 1	Mus musculus	94-96
8200066-5	1994	A second phenomenon we observed was the greatly increased binding of FN to the surface of the cells, both in dimeric and multimeric forms, caused by RA treatment.	Tretinoin	149-151	fibronectin 1	Mus musculus	69-71
8200066-7	1994	We postulate that the combined action of RA in causing decreased FN synthesis and increased FN binding to the cell surface is the reason for the apparent antagonism of RA to the TPA-stimulated release of FN.	Tretinoin	41-43	fibronectin 1	Mus musculus	65-67
8200066-7	1994	We postulate that the combined action of RA in causing decreased FN synthesis and increased FN binding to the cell surface is the reason for the apparent antagonism of RA to the TPA-stimulated release of FN.	Tretinoin	41-43	fibronectin 1	Mus musculus	92-94
8200066-7	1994	We postulate that the combined action of RA in causing decreased FN synthesis and increased FN binding to the cell surface is the reason for the apparent antagonism of RA to the TPA-stimulated release of FN.	Tretinoin	41-43	fibronectin 1	Mus musculus	92-94
8200066-7	1994	We postulate that the combined action of RA in causing decreased FN synthesis and increased FN binding to the cell surface is the reason for the apparent antagonism of RA to the TPA-stimulated release of FN.	Tretinoin	168-170	fibronectin 1	Mus musculus	92-94
8200066-7	1994	We postulate that the combined action of RA in causing decreased FN synthesis and increased FN binding to the cell surface is the reason for the apparent antagonism of RA to the TPA-stimulated release of FN.	Tretinoin	168-170	fibronectin 1	Mus musculus	92-94
8200066-7	1994	We postulate that the combined action of RA in causing decreased FN synthesis and increased FN binding to the cell surface is the reason for the apparent antagonism of RA to the TPA-stimulated release of FN.	Tetradecanoylphorbol Acetate	178-181	fibronectin 1	Mus musculus	65-67
8200066-7	1994	We postulate that the combined action of RA in causing decreased FN synthesis and increased FN binding to the cell surface is the reason for the apparent antagonism of RA to the TPA-stimulated release of FN.	Tetradecanoylphorbol Acetate	178-181	fibronectin 1	Mus musculus	92-94
8200066-7	1994	We postulate that the combined action of RA in causing decreased FN synthesis and increased FN binding to the cell surface is the reason for the apparent antagonism of RA to the TPA-stimulated release of FN.	Tetradecanoylphorbol Acetate	178-181	fibronectin 1	Mus musculus	92-94
8200066-10	1994	BC also inhibited FN synthesis and thus inhibited the TPA-stimulated release of FN, similar to RA, but to a lesser extent.	beta Carotene	0-2	fibronectin 1	Mus musculus	18-20
8106754-0	1994	In vivo prevention of corticosteroid-induced skin atrophy by tretinoin in the hairless mouse is accompanied by modulation of collagen, glycosaminoglycans, and fibronectin.	Tretinoin	61-70	fibronectin 1	Mus musculus	159-170
8045593-6	1994	Interaction with fibrinogen and fibronectin also primed macrophages for an enhanced TNF-alpha response to leishmanial parasites, but this was only translated into enhanced nitrite responses in the presence of IFN-gamma.	Nitrites	172-179	fibronectin 1	Mus musculus	32-43
8062907-1	1994	Phosphorylation of both tyrosine and serine residues of focal adhesion kinase (FAK) was stimulated by the adhesion of BALB/c mouse 3T3 cells to fibronectin, but phosphorylation of threonine was not detectable.	Tyrosine	24-32	fibronectin 1	Mus musculus	144-155
8062907-1	1994	Phosphorylation of both tyrosine and serine residues of focal adhesion kinase (FAK) was stimulated by the adhesion of BALB/c mouse 3T3 cells to fibronectin, but phosphorylation of threonine was not detectable.	Serine	37-43	fibronectin 1	Mus musculus	144-155
8138582-2	1994	It has been postulated that CS-PG participates in HPC adhesion to pericellular stromal fibronectin by interacting with its heparin-promoting binding region.	Cesium	28-30	fibronectin 1	Mus musculus	87-98
8138582-6	1994	However, beta-xyloside treatment which reduces the abundance of membrane-associated CS-PG, as evidenced by molecular sieve chromatography, produced a major and specific decrease in HPC adhesion to the heparin-promoting binding fragment of fibronectin.	beta-xyloside	9-22	fibronectin 1	Mus musculus	239-250
8138582-6	1994	However, beta-xyloside treatment which reduces the abundance of membrane-associated CS-PG, as evidenced by molecular sieve chromatography, produced a major and specific decrease in HPC adhesion to the heparin-promoting binding fragment of fibronectin.	Cesium	84-86	fibronectin 1	Mus musculus	239-250
8138582-6	1994	However, beta-xyloside treatment which reduces the abundance of membrane-associated CS-PG, as evidenced by molecular sieve chromatography, produced a major and specific decrease in HPC adhesion to the heparin-promoting binding fragment of fibronectin.	Heparin	201-208	fibronectin 1	Mus musculus	239-250
8138582-7	1994	These results indicate that CS-PG are involved in HPC interaction with fibronectin, in a mode that seems to be dependent on the differentiation stage of HPC.	Cesium	28-30	fibronectin 1	Mus musculus	71-82
7509207-7	1994	Mast cells from c-kit mutant mice adhere to fibronectin on stimulation with phorbol 12-myristate 13-acetate (PMA), but not on stimulation with steel factor, indicating that stimulation of integrin adhesiveness requires activation of the c-kit protein tyrosine kinase.	Tetradecanoylphorbol Acetate	76-107	fibronectin 1	Mus musculus	44-55
7509207-7	1994	Mast cells from c-kit mutant mice adhere to fibronectin on stimulation with phorbol 12-myristate 13-acetate (PMA), but not on stimulation with steel factor, indicating that stimulation of integrin adhesiveness requires activation of the c-kit protein tyrosine kinase.	Tetradecanoylphorbol Acetate	109-112	fibronectin 1	Mus musculus	44-55
7905794-0	1994	Inhibition of CD4+ T lymphocyte binding to fibronectin and immune-cell accumulation in inflammatory sites by non-peptidic mimetics of Arg-Gly-Asp.	Arginine	134-137	fibronectin 1	Mus musculus	43-54
7905794-0	1994	Inhibition of CD4+ T lymphocyte binding to fibronectin and immune-cell accumulation in inflammatory sites by non-peptidic mimetics of Arg-Gly-Asp.	Glycine	138-141	fibronectin 1	Mus musculus	43-54
7905794-0	1994	Inhibition of CD4+ T lymphocyte binding to fibronectin and immune-cell accumulation in inflammatory sites by non-peptidic mimetics of Arg-Gly-Asp.	Aspartic Acid	142-145	fibronectin 1	Mus musculus	43-54
7905794-5	1994	We now report that freezing the conformational degrees of freedom in the spacer chain, which fixes the relative orientation of the guanidinium and carboxylate side groups in a favourable manner, results in a higher level of inhibition of T cell binding to immobilized fibronectin, an RGD-containing ECM glycoprotein.	Guanidine	131-142	fibronectin 1	Mus musculus	268-279
7905794-5	1994	We now report that freezing the conformational degrees of freedom in the spacer chain, which fixes the relative orientation of the guanidinium and carboxylate side groups in a favourable manner, results in a higher level of inhibition of T cell binding to immobilized fibronectin, an RGD-containing ECM glycoprotein.	carboxylate	147-158	fibronectin 1	Mus musculus	268-279
8130891-7	1994	The progesterone antagonist RU 486 also attenuated basal fibronectin production by F1 and F3 granulosa cells, but only the highest concentration affected SYF cells.	Mifepristone	28-34	fibronectin 1	Mus musculus	57-68
7924666-9	1994	The contents of wound tissue DNA and hydroxyproline in Fn group were significantly increased on day 5, and total protein was significantly increased on day 10.	Hydroxyproline	37-51	fibronectin 1	Mus musculus	55-57
7504710-4	1994	As expected, 80 to 90% of PMA-activated MCP5/L cells or BMCMC adhered to FN.	bmcmc	56-61	fibronectin 1	Mus musculus	73-75
7504710-5	1994	In addition, SCF promoted MCP5/L cell or BMCMC adhesion to FN in a dose-response fashion with 50 to 60% of BMCMC adhering to FN at a concentration 10 ng/ml of SCF.	bmcmc	41-46	fibronectin 1	Mus musculus	59-61
7504710-5	1994	In addition, SCF promoted MCP5/L cell or BMCMC adhesion to FN in a dose-response fashion with 50 to 60% of BMCMC adhering to FN at a concentration 10 ng/ml of SCF.	bmcmc	107-112	fibronectin 1	Mus musculus	59-61
7504710-7	1994	Adhesion of SCF stimulated BMCMC to FN did not require IL-3, but was dependent on the concentration of FN used to coat the assay surface.	bmcmc	27-32	fibronectin 1	Mus musculus	36-38
7504710-7	1994	Adhesion of SCF stimulated BMCMC to FN did not require IL-3, but was dependent on the concentration of FN used to coat the assay surface.	bmcmc	27-32	fibronectin 1	Mus musculus	103-105
7504656-4	1993	The Arg-Gly-Asp (RGD)-containing peptide, a major adhesive ligand of ECM, is present in various plasma and matrix glycoproteins, such as FN and VN.	Arginine	4-7	fibronectin 1	Mus musculus	137-139
7504656-4	1993	The Arg-Gly-Asp (RGD)-containing peptide, a major adhesive ligand of ECM, is present in various plasma and matrix glycoproteins, such as FN and VN.	glycylaspartic acid	8-15	fibronectin 1	Mus musculus	137-139
8262151-3	1993	The same concentration of BFA completely blocked accumulation of secretory proteins, e.g., fibronectin into the culture medium, probably due to retention in ER.	Brefeldin A	26-29	fibronectin 1	Mus musculus	91-102
8106754-11	1994	Fibronectin, which was increased by the steroid:vehicle treatment, was reduced to more normal levels by steroid:tretinoin.	Steroids	40-47	fibronectin 1	Mus musculus	0-11
8106754-11	1994	Fibronectin, which was increased by the steroid:vehicle treatment, was reduced to more normal levels by steroid:tretinoin.	Steroids	104-111	fibronectin 1	Mus musculus	0-11
8106754-11	1994	Fibronectin, which was increased by the steroid:vehicle treatment, was reduced to more normal levels by steroid:tretinoin.	Tretinoin	112-121	fibronectin 1	Mus musculus	0-11
8274453-9	1993	Retinoic acid-treated, but not untreated, cells lost expression of vimentin and fibronectin, gained the ability to incorporate acetylated low density lipoprotein, and expressed Factor VIII-related antigen.	Tretinoin	0-13	fibronectin 1	Mus musculus	80-91
8222396-10	1993	These results demonstrate that the conjugation of RGDS peptide with SCM-chitin led to augmentation of therapeutic potential to cancer metastasis, thus implying an importance of the conjugation of cell-adhesive RGDS peptide with structurally heparin-like SCM-chitin, which possess binding ability to the heparin-binding domain of fibronectin or laminin and extremely low anticoagulant properties.	scm-chitin	68-78	fibronectin 1	Mus musculus	329-340
8216307-2	1993	Addition of okadaic acid to v-Src-transformed BALB/c 3T3 cells reverted them to a flat morphology, increased fibronectin levels in the extracellular matrix, reduced saturation density, and inhibited the formation of colonies in soft agar.	Okadaic Acid	12-24	fibronectin 1	Mus musculus	109-120
8287052-0	1993	Synthetic Arg-Gly-Asp-Ser analogues of the cell recognition site of fibronectin that retain antimetastatic and anti-cell adhesive properties.	Arginine	10-13	fibronectin 1	Mus musculus	68-79
8287052-0	1993	Synthetic Arg-Gly-Asp-Ser analogues of the cell recognition site of fibronectin that retain antimetastatic and anti-cell adhesive properties.	Glycine	14-17	fibronectin 1	Mus musculus	68-79
8287052-0	1993	Synthetic Arg-Gly-Asp-Ser analogues of the cell recognition site of fibronectin that retain antimetastatic and anti-cell adhesive properties.	Aspartic Acid	18-21	fibronectin 1	Mus musculus	68-79
8287052-0	1993	Synthetic Arg-Gly-Asp-Ser analogues of the cell recognition site of fibronectin that retain antimetastatic and anti-cell adhesive properties.	Serine	22-25	fibronectin 1	Mus musculus	68-79
8287052-1	1993	Synthetic peptide analogues of the Arg-Gly-Asp-Ser (RGDS) sequence of fibronectin in which the amino acid of Gly was substituted with another one, named X, i.e. Arg-X-Asp-Ser (R-X-DS), and N-terminal modified R-X-DS have been synthesized to examine their antimetastatic effects in murine lung or liver metastasis models, as well as the inhibitory effect on tumor cell invasion, migration and adhesion in vitro.	arginyl-glycyl-aspartyl-serine	35-50	fibronectin 1	Mus musculus	70-81
8287052-1	1993	Synthetic peptide analogues of the Arg-Gly-Asp-Ser (RGDS) sequence of fibronectin in which the amino acid of Gly was substituted with another one, named X, i.e. Arg-X-Asp-Ser (R-X-DS), and N-terminal modified R-X-DS have been synthesized to examine their antimetastatic effects in murine lung or liver metastasis models, as well as the inhibitory effect on tumor cell invasion, migration and adhesion in vitro.	Glycine	39-42	fibronectin 1	Mus musculus	70-81
8287052-1	1993	Synthetic peptide analogues of the Arg-Gly-Asp-Ser (RGDS) sequence of fibronectin in which the amino acid of Gly was substituted with another one, named X, i.e. Arg-X-Asp-Ser (R-X-DS), and N-terminal modified R-X-DS have been synthesized to examine their antimetastatic effects in murine lung or liver metastasis models, as well as the inhibitory effect on tumor cell invasion, migration and adhesion in vitro.	arg-x-asp-ser	161-174	fibronectin 1	Mus musculus	70-81
8360217-3	1993	A cell growth factor protein (insulin) and/or a cell-adhesion protein (fibronectin) were immobilized on surface-hydrolyzed poly(methyl methacrylate) membranes.	Polymethyl Methacrylate	123-148	fibronectin 1	Mus musculus	71-82
1528852-5	1992	The tyrosine-phosphorylated state is regained within minutes when the cells are replated onto fibronectin.	Tyrosine	4-12	fibronectin 1	Mus musculus	94-105
8252842-5	1993	Within 12 hr, 8-br-cAMP enhanced fibronectin deposition dose-dependently by F3 and SYF cells, but not by F1 cells.	8-Bromo Cyclic Adenosine Monophosphate	14-23	fibronectin 1	Mus musculus	33-44
8252842-6	1993	The amount of fibronectin deposition caused by 8-br-cAMP (which was greater after 24 hr incubation) was 0.10- to 0.16-fold for F1 cells; 0.20- to 0.81-fold for F3 cells and more than 30-fold for SYF cells.	8-Bromo Cyclic Adenosine Monophosphate	47-56	fibronectin 1	Mus musculus	14-25
8252842-8	1993	8-bromo cAMP stimulated fibronectin secretion in medium dose-dependently by F3 and SYF cells, however, it had only a marginal stimulatory effect on this process in F1 cells.	8-bromo	0-7	fibronectin 1	Mus musculus	24-35
8252842-8	1993	8-bromo cAMP stimulated fibronectin secretion in medium dose-dependently by F3 and SYF cells, however, it had only a marginal stimulatory effect on this process in F1 cells.	Cyclic AMP	8-12	fibronectin 1	Mus musculus	24-35
8252842-10	1993	Total (deposited plus medium plus cell associated) fibronectin production was elevated in dose- and time-dependent manner by 8-br-cAMP in F3 and SYF cells, but only at high concentrations in F1 cells.	8-Bromo Cyclic Adenosine Monophosphate	125-134	fibronectin 1	Mus musculus	51-62
8252842-11	1993	Like deposited fibronectin, the relative effect of 8-br-cAMP on fibronectin secreted in the medium and on total fibronectin production was greatest in immature SYF cells.	8-Bromo Cyclic Adenosine Monophosphate	51-60	fibronectin 1	Mus musculus	64-75
8252842-11	1993	Like deposited fibronectin, the relative effect of 8-br-cAMP on fibronectin secreted in the medium and on total fibronectin production was greatest in immature SYF cells.	8-Bromo Cyclic Adenosine Monophosphate	51-60	fibronectin 1	Mus musculus	64-75
8422710-4	1993	Rather, these studies indicated that adriamycin-induced inhibition of melanoma cell invasion was accompanied by a corresponding decrease in the ability of adriamycin-treated tumor cells to migrate in response to several isolated ECM components including fibronectin, laminin and basement membrane (type IV) collagen.	Doxorubicin	37-47	fibronectin 1	Mus musculus	254-265
8422710-4	1993	Rather, these studies indicated that adriamycin-induced inhibition of melanoma cell invasion was accompanied by a corresponding decrease in the ability of adriamycin-treated tumor cells to migrate in response to several isolated ECM components including fibronectin, laminin and basement membrane (type IV) collagen.	Doxorubicin	155-165	fibronectin 1	Mus musculus	254-265
8422710-6	1993	Instead, adriamycin-treated cells actually exhibited a slightly increased propensity (compared to untreated control cells) to adhere on fibronectin-, laminin-, and type IV collagen-coated substrata.	Doxorubicin	9-19	fibronectin 1	Mus musculus	136-147
8225461-3	1993	Although treatment of these surfaces with fibronectin, keratin sulfate, and the fibronectin-derived peptide GRGDS (glycine-arginine-glycine-glutamate-serine) increases cellular binding by 29% to 31%, the relative binding to titanium was 5 to 10 times lower than binding to collagen I gels.	Serine	150-156	fibronectin 1	Mus musculus	42-53
8225461-3	1993	Although treatment of these surfaces with fibronectin, keratin sulfate, and the fibronectin-derived peptide GRGDS (glycine-arginine-glycine-glutamate-serine) increases cellular binding by 29% to 31%, the relative binding to titanium was 5 to 10 times lower than binding to collagen I gels.	Serine	150-156	fibronectin 1	Mus musculus	80-91
8225461-3	1993	Although treatment of these surfaces with fibronectin, keratin sulfate, and the fibronectin-derived peptide GRGDS (glycine-arginine-glycine-glutamate-serine) increases cellular binding by 29% to 31%, the relative binding to titanium was 5 to 10 times lower than binding to collagen I gels.	Titanium	224-232	fibronectin 1	Mus musculus	42-53
8225461-3	1993	Although treatment of these surfaces with fibronectin, keratin sulfate, and the fibronectin-derived peptide GRGDS (glycine-arginine-glycine-glutamate-serine) increases cellular binding by 29% to 31%, the relative binding to titanium was 5 to 10 times lower than binding to collagen I gels.	Titanium	224-232	fibronectin 1	Mus musculus	80-91
8383687-4	1993	Moreover, Bt2cAMP-treated cells secreted a large quantity of fibronectin, which was deposited on the extended cell surface in the culture medium.	Bucladesine	10-17	fibronectin 1	Mus musculus	61-72
1459201-7	1992	In contrast, two inhibitors, H-7 and staurosporine, for which protein kinase C is a common target, increase two- to fourfold the attachment of HT1080, OVCAR-4, and B16F10 cells to laminin but not to fibronectin.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	29-32	fibronectin 1	Mus musculus	199-210
1459201-7	1992	In contrast, two inhibitors, H-7 and staurosporine, for which protein kinase C is a common target, increase two- to fourfold the attachment of HT1080, OVCAR-4, and B16F10 cells to laminin but not to fibronectin.	Staurosporine	37-50	fibronectin 1	Mus musculus	199-210
1460656-6	1992	Immunisation of mice with formalin-treated gal-FnBP resulted in high antibody titres against the fibronectin-binding part of this fusion protein.	Formaldehyde	26-34	fibronectin 1	Mus musculus	97-108
8315934-5	1993	Thromboxane increased steady-state mRNA levels for all three laminin chains, type IV collagen, and fibronectin, but decreased the level of mRNA for heparan sulfate proteoglycan.	Thromboxanes	0-11	fibronectin 1	Mus musculus	99-110
8315934-6	1993	In contrast, incubation with carbo-prostacyclin, a stable analog of prostacyclin, decreased the steady-state mRNA level for the laminin A and B1 chains, type IV collagen and fibronectin, and increased the mRNA level for heparan sulfate proteoglycan and laminin B2.	carboprostacyclin	29-47	fibronectin 1	Mus musculus	174-185
8315934-6	1993	In contrast, incubation with carbo-prostacyclin, a stable analog of prostacyclin, decreased the steady-state mRNA level for the laminin A and B1 chains, type IV collagen and fibronectin, and increased the mRNA level for heparan sulfate proteoglycan and laminin B2.	Epoprostenol	35-47	fibronectin 1	Mus musculus	174-185
8387531-0	1993	Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown.	inositol lipid	35-49	fibronectin 1	Mus musculus	12-23
8387531-0	1993	Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown.	inositol lipid	86-100	fibronectin 1	Mus musculus	12-23
8387531-4	1993	PDGF induced a threefold increase in release of water-soluble inositol phosphates in C3H 10T1/2 fibroblasts when cells were attached to FN, but had little effect in suspended cells.	Water	48-53	fibronectin 1	Mus musculus	136-138
8387531-4	1993	PDGF induced a threefold increase in release of water-soluble inositol phosphates in C3H 10T1/2 fibroblasts when cells were attached to FN, but had little effect in suspended cells.	Inositol Phosphates	62-81	fibronectin 1	Mus musculus	136-138
8387531-8	1993	Furthermore, a dramatic increase in synthesis of PIP2 could be measured in cells within 2 min after reattachment to FN in the absence of PDGF.	Phosphatidylinositol 4,5-Diphosphate	49-53	fibronectin 1	Mus musculus	116-118
8387531-9	1993	These results show that FN acts directly to stimulate PIP2 synthesis, and that it also enhances PIP2 hydrolysis in response to PDGF.	Phosphatidylinositol 4,5-Diphosphate	54-58	fibronectin 1	Mus musculus	24-26
8364464-5	1993	The effect disappeared by the treatment of NMS with gelatin-Sepharose which removed fibronectin (FN) from the serum, suggesting a significant contribution of FN on GIZUP.	Sepharose	60-69	fibronectin 1	Mus musculus	84-95
8364464-5	1993	The effect disappeared by the treatment of NMS with gelatin-Sepharose which removed fibronectin (FN) from the serum, suggesting a significant contribution of FN on GIZUP.	Sepharose	60-69	fibronectin 1	Mus musculus	97-99
8364464-6	1993	In addition, the administration of beta-glucan in vivo elevated the concentration of FN in serum by acute phase response and enhanced GIZUP, suggesting the positive contribution of acute phase responses on beta-glucan mediated immunopharmacological activities.	beta-Glucans	35-46	fibronectin 1	Mus musculus	85-87
8364464-6	1993	In addition, the administration of beta-glucan in vivo elevated the concentration of FN in serum by acute phase response and enhanced GIZUP, suggesting the positive contribution of acute phase responses on beta-glucan mediated immunopharmacological activities.	beta-Glucans	206-217	fibronectin 1	Mus musculus	85-87
8507559-7	1993	The other cell line, 4CQ, synthesizes a matrix consisting of fibronectin and entactin.	4cq	21-24	fibronectin 1	Mus musculus	61-72
8384227-6	1993	Nedocromil sodium also interfered with the mitogen-induced interleukin-2 and tumor necrosis factor production by T cells and with their ability to adhere to the bound protein components of the extracellular matrix laminin and fibronectin.	Nedocromil	0-17	fibronectin 1	Mus musculus	226-237
7678813-11	1993	TPA also increased the expression of GP IIb/IIIa, fibronectin and factor VIII:RAg.	Tetradecanoylphorbol Acetate	0-3	fibronectin 1	Mus musculus	50-61
8440752-0	1993	Effect of retinyl acetate on the assembly of the fibronectin extracellular matrix and the processing of the fibronectin receptor beta subunit of confluent C3H/10T1/2 mouse embryo fibroblasts.	retinol acetate	10-25	fibronectin 1	Mus musculus	49-60
8440752-2	1993	Confluent cultures of these cells cultured in the presence of 0.3 micrograms/ml of retinyl acetate released cell surface fibronectin and the extracellular matrix fibronectin fibrils were disorganized.	retinol acetate	83-98	fibronectin 1	Mus musculus	121-132
8440752-2	1993	Confluent cultures of these cells cultured in the presence of 0.3 micrograms/ml of retinyl acetate released cell surface fibronectin and the extracellular matrix fibronectin fibrils were disorganized.	retinol acetate	83-98	fibronectin 1	Mus musculus	162-173
8440752-3	1993	The immunoblot analysis demonstrated that the number of the fibronectin receptor was decreased in the prolonged culturing of retinyl acetate-treated cells.	retinol acetate	125-140	fibronectin 1	Mus musculus	60-71
8440752-5	1993	1-deoxymannojirimycin (MNJ), which is an inhibitor of oligosaccharide processing, induced disorganization of the extracellular matrix fibronectin assembly similar to that observed with retinyl acetate.	1-Deoxynojirimycin	0-21	fibronectin 1	Mus musculus	134-145
8440752-5	1993	1-deoxymannojirimycin (MNJ), which is an inhibitor of oligosaccharide processing, induced disorganization of the extracellular matrix fibronectin assembly similar to that observed with retinyl acetate.	CHEMBL4460509	23-26	fibronectin 1	Mus musculus	134-145
8440752-6	1993	The results of this study suggest that a mechanism of action of retinyl acetate is inhibition of the glycosylation during processing of the fibronectin receptor, a step necessary for fibronectin binding and for assembly of the extracellular matrix.	retinol acetate	64-79	fibronectin 1	Mus musculus	140-151
8440752-6	1993	The results of this study suggest that a mechanism of action of retinyl acetate is inhibition of the glycosylation during processing of the fibronectin receptor, a step necessary for fibronectin binding and for assembly of the extracellular matrix.	retinol acetate	64-79	fibronectin 1	Mus musculus	183-194
1385444-3	1992	Rat embryo fibroblasts, mouse Balb/c 3T3, and NIH 3T3 cells plated on fibronectin-coated surfaces revealed elevated phosphotyrosine levels in a cluster of proteins between 115 and 130 kD.	Phosphotyrosine	116-131	fibronectin 1	Mus musculus	70-81
1385444-5	1992	Integrin mediation of this effect was suggested by finding the same pattern of elevated tyrosine phosphorylation in cells plated on the cell-binding fragment of fibronectin and in cells plated on a synthetic polymer containing multiple RGD sequences.	Tyrosine	88-96	fibronectin 1	Mus musculus	161-172
1385448-8	1992	This inhibition by heparin was also observed with laminin and fibronectin and, in the case of perlecan, was found to be independent of heparin binding to substrate.	Heparin	19-26	fibronectin 1	Mus musculus	62-73
1365841-5	1992	The percent of inhibition of macrophage adherence to fibronectin by arginine-glycine-aspartic acid-serine (RGDS) peptide (58.1 +/- 2.7%) was significantly (P < 0.01) higher than that in cells from young mice (23.1 +/- 5.7%).	arginine-glycine-aspartic acid-serine	68-105	fibronectin 1	Mus musculus	53-64
1399143-11	1992	B16a-cell attachment to fibronectin resulted in increased metabolism of arachidonic acid to 12(S)-HETE, which was inhibited by lipoxygenase but not by cyclo-oxygenase inhibitors.	Arachidonic Acid	72-88	fibronectin 1	Mus musculus	24-35
1399143-11	1992	B16a-cell attachment to fibronectin resulted in increased metabolism of arachidonic acid to 12(S)-HETE, which was inhibited by lipoxygenase but not by cyclo-oxygenase inhibitors.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	92-102	fibronectin 1	Mus musculus	24-35
1399143-14	1992	These data suggest that B16a-cell spreading on fibronectin is initiated by a lipoxygenase metabolite [12(S)-HETE] of arachidonic acid and is mediated by protein kinase C.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	102-112	fibronectin 1	Mus musculus	47-58
1399143-14	1992	These data suggest that B16a-cell spreading on fibronectin is initiated by a lipoxygenase metabolite [12(S)-HETE] of arachidonic acid and is mediated by protein kinase C.	Arachidonic Acid	117-133	fibronectin 1	Mus musculus	47-58
1394189-3	1992	Binding and cross-linking experiments using 125I-labeled bFGF revealed that these alterations were associated with an up-regulation of high affinity receptors bFGF receptors was induced by these compounds in spbFGF cells that were seeded on fibronectin to enforce a firm cell attachment and flattening.	Iodine-125	44-48	fibronectin 1	Mus musculus	241-252
1429751-1	1992	Plasma fibronectin (pFN) adhesion mechanisms on inert substrata were evaluated for murine fibroblasts (3T3) and human neuroblastoma (Platt) cells using glass coverslips chemically derivatized with a self-assembled monolayer of aliphatic chains terminated with a specific endgroup to interact with adsorbed pFN: [CH3], [SH], [SCOCH3], [NH2], [SO3H], or underivatized glass [SiOH].	(R)-Fenoprofen	20-23	fibronectin 1	Mus musculus	7-18
1486236-3	1992	Certain metabolite sequences including Gly, Asp, Arg, and Ser (GAAS) proved to be critical for cell interactions, e.g. with fibronectin.	Glycine	39-42	fibronectin 1	Mus musculus	124-135
1486236-3	1992	Certain metabolite sequences including Gly, Asp, Arg, and Ser (GAAS) proved to be critical for cell interactions, e.g. with fibronectin.	Aspartic Acid	44-47	fibronectin 1	Mus musculus	124-135
1486236-3	1992	Certain metabolite sequences including Gly, Asp, Arg, and Ser (GAAS) proved to be critical for cell interactions, e.g. with fibronectin.	Arginine	49-52	fibronectin 1	Mus musculus	124-135
1486236-3	1992	Certain metabolite sequences including Gly, Asp, Arg, and Ser (GAAS) proved to be critical for cell interactions, e.g. with fibronectin.	Serine	58-61	fibronectin 1	Mus musculus	124-135
1486236-3	1992	Certain metabolite sequences including Gly, Asp, Arg, and Ser (GAAS) proved to be critical for cell interactions, e.g. with fibronectin.	gaas	63-67	fibronectin 1	Mus musculus	124-135
1386358-0	1992	Maturation of murine erythroleukemia cells committed to differentiation requires protein kinase C. Treatment of murine erythroleukemia cells (MELC) attached to fibronectin-coated dishes with dimethyl sulfoxide causes the cells to become committed to the erythroid differentiation pathway.	Dimethyl Sulfoxide	191-209	fibronectin 1	Mus musculus	160-171
1517210-6	1992	Moreover, increased DNA synthesis of 3T3 cells was observed when the 3T3 cells were exposed to beads coated with the fibronectin-syndecan-bFGF complex, indicating that bFGF remains biologically active even when immobilized to matrix via the heparan sulfate chains of syndecan.	Heparitin Sulfate	241-256	fibronectin 1	Mus musculus	117-128
1386358-9	1992	Immunoprecipitation of surface-labeled proteins by an anti-fibronectin receptor (integrin) antibody showed that PMA-treated cultures had more fibronectin receptor protein than untreated cultures 6 days post-induction.	Tetradecanoylphorbol Acetate	112-115	fibronectin 1	Mus musculus	59-70
1386358-9	1992	Immunoprecipitation of surface-labeled proteins by an anti-fibronectin receptor (integrin) antibody showed that PMA-treated cultures had more fibronectin receptor protein than untreated cultures 6 days post-induction.	Tetradecanoylphorbol Acetate	112-115	fibronectin 1	Mus musculus	142-153
1386358-10	1992	As a result, cultures of committed MELC treated with PMA remained attached to fibronectin-coated plates, whereas non-PMA-treated cells were released into the culture medium.	Tetradecanoylphorbol Acetate	53-56	fibronectin 1	Mus musculus	78-89
1399825-3	1992	In vitro, triflavin dose-dependently inhibits adhesion of B16-F10 melanoma cells to extracellular matrices (ECMs; i.e., fibronectin, fibrinogen, vitronectin, and collagen type I).	triflavin	10-19	fibronectin 1	Mus musculus	120-131
1639143-4	1992	1,25(OH)2D3 also induced an increase in cell-surface-associated fibronectin.	Calcitriol	0-11	fibronectin 1	Mus musculus	64-75
1399825-6	1992	These results imply that the inhibitory effect of triflavin on the adhesion of tumor cells to ECMs (e.g., fibronectin, vitronectin and collagen type I) and/or tumor cell-induced platelet aggregation may be partially responsible for its antimetastatic activity in C57BL/6 mice.	triflavin	50-59	fibronectin 1	Mus musculus	106-117
1417873-4	1992	Moreover, activity of the stimulatory FN was not affected by inclusion of cytochalasin B, which is known to release FN from cell surface by disorganizing actin cytoarchitecture.	Cytochalasin B	74-88	fibronectin 1	Mus musculus	116-118
1612122-10	1992	We conclude that interactions between MA-PG and a putative integrin-like molecule in FDCP-1 and the heparin and the cell binding domains in pericellular FN in the stromal cells contribute to the stabilization of progenitor-stromal cell binding which originally comes about by homing receptors of progenitor cells.	ma-pg	38-43	fibronectin 1	Mus musculus	153-155
1354362-8	1992	The current induced by fibronectin was not blocked by apamin, alpha-charybdotoxin or glibenclamide, but was abolished by high concentrations of tetraethylammonium (TEA).	alpha-charybdotoxin	62-81	fibronectin 1	Mus musculus	23-34
1354362-8	1992	The current induced by fibronectin was not blocked by apamin, alpha-charybdotoxin or glibenclamide, but was abolished by high concentrations of tetraethylammonium (TEA).	Tetraethylammonium	144-162	fibronectin 1	Mus musculus	23-34
1354362-8	1992	The current induced by fibronectin was not blocked by apamin, alpha-charybdotoxin or glibenclamide, but was abolished by high concentrations of tetraethylammonium (TEA).	Tetraethylammonium	164-167	fibronectin 1	Mus musculus	23-34
1607392-0	1992	Cell surface phosphatidylinositol-anchored heparan sulfate proteoglycan initiates mouse melanoma cell adhesion to a fibronectin-derived, heparin-binding synthetic peptide.	Phosphatidylinositols	13-33	fibronectin 1	Mus musculus	116-127
1916899-2	1991	BMCMC required activation by phorbol myristate acetate (PMA) to adhere to fibronectin, whereas MCP-5 displayed spontaneous adherence.	bmcmc	0-5	fibronectin 1	Mus musculus	74-85
1534668-8	1992	This conclusion is supported by the observation that DC pulsed with formalin-modified FnBP (with a 65% decreased ability to bind fibronectin) formed fewer clusters with T-immune cells than dendritic cells pulsed with native, non-treated FnBP.	Formaldehyde	68-76	fibronectin 1	Mus musculus	129-140
1534668-8	1992	This conclusion is supported by the observation that DC pulsed with formalin-modified FnBP (with a 65% decreased ability to bind fibronectin) formed fewer clusters with T-immune cells than dendritic cells pulsed with native, non-treated FnBP.	fnbp	86-90	fibronectin 1	Mus musculus	129-140
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Cesium	140-142	fibronectin 1	Mus musculus	153-155
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Arginine	183-186	fibronectin 1	Mus musculus	153-155
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Glycine	187-190	fibronectin 1	Mus musculus	153-155
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Aspartic Acid	56-59	fibronectin 1	Mus musculus	153-155
1916899-2	1991	BMCMC required activation by phorbol myristate acetate (PMA) to adhere to fibronectin, whereas MCP-5 displayed spontaneous adherence.	Tetradecanoylphorbol Acetate	56-59	fibronectin 1	Mus musculus	74-85
1916899-3	1991	The binding of both MCP-5 and BMCMC was dose dependent, with maximal adhesion at a fibronectin concentration of 20 micrograms/ml.	bmcmc	30-35	fibronectin 1	Mus musculus	83-94
1710455-1	1991	Several kinds of cyclic peptides containing an L-arginine-glycine-L-aspartic acid RGD sequence were synthesized by the liquid phase method, and we investigated their effects on the attachment of mouse B16 melanoma cells onto fibronectin-coated well.	Peptides, Cyclic	17-32	fibronectin 1	Mus musculus	225-236
1937964-13	1991	In B16a cells, the disruption of intermediate filaments and/or microfilaments prevents the 12-(S)-HETE-induced increase in plasma membrane alpha IIb beta 3 and enhanced tumor-cell adhesion to fibronectin.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	91-102	fibronectin 1	Mus musculus	192-203
1955379-0	1991	Recombinant fusion polypeptide with cell- and heparin-binding domains of fibronectin inhibits liver metastasis of L5178Y-ML25 lymphoma cells.	Heparin	46-53	fibronectin 1	Mus musculus	73-84
1955379-11	1991	Thus, the fusion of H-271 with C-274 (i.e. CH-271) augments the antimetastatic property of H-271, possibly through the interaction between tumor cells and the heparin-binding domain of fibronectin.	Carbon	31-32	fibronectin 1	Mus musculus	185-196
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Glycine	36-39	fibronectin 1	Mus musculus	153-155
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Proline	40-43	fibronectin 1	Mus musculus	153-155
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Glutamic Acid	44-47	fibronectin 1	Mus musculus	153-155
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Isoleucine	48-51	fibronectin 1	Mus musculus	153-155
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	leu-asp-val-pro-ser-thr	52-75	fibronectin 1	Mus musculus	153-155
1789137-8	1991	Furthermore, a fibronectin attachment peptide, GRGDTP, that competes with matrix proteins for specific binding to cell surface adhesion receptors also inhibited the stimulation of proliferation by ascorbic acid almost completely.	Ascorbic Acid	197-210	fibronectin 1	Mus musculus	15-26
1936196-5	1991	Fibronectin biosynthesis, determined by immunoprecipitation of 35S-methionine labeled peptides in SDS-extracts of skin increased progressively with age from about 2% of total incorporated radioactivity in fibronectin at 2 months to 4% at 22 months.	Sulfur-35	63-66	fibronectin 1	Mus musculus	0-11
1936196-5	1991	Fibronectin biosynthesis, determined by immunoprecipitation of 35S-methionine labeled peptides in SDS-extracts of skin increased progressively with age from about 2% of total incorporated radioactivity in fibronectin at 2 months to 4% at 22 months.	Methionine	67-77	fibronectin 1	Mus musculus	0-11
1936196-5	1991	Fibronectin biosynthesis, determined by immunoprecipitation of 35S-methionine labeled peptides in SDS-extracts of skin increased progressively with age from about 2% of total incorporated radioactivity in fibronectin at 2 months to 4% at 22 months.	Peptides	86-94	fibronectin 1	Mus musculus	0-11
1936196-5	1991	Fibronectin biosynthesis, determined by immunoprecipitation of 35S-methionine labeled peptides in SDS-extracts of skin increased progressively with age from about 2% of total incorporated radioactivity in fibronectin at 2 months to 4% at 22 months.	Sodium Dodecyl Sulfate	98-101	fibronectin 1	Mus musculus	0-11
2265419-1	1990	Folate deficient murine B16 melanoma cells adhered more rapidly and in higher percentages to plastic plates or dishes coated with laminin or fibronectin than folate replete cells.	Folic Acid	0-6	fibronectin 1	Mus musculus	141-152
2144604-6	1990	In contrast, translocation of cells through artificial matrices mediated by T cell FN is a biophysical process dependent on interactions between surface heparan sulfates on responding cells and FN amino-terminal heparin-binding and gelatin-binding domains.	Heparitin Sulfate	153-169	fibronectin 1	Mus musculus	83-85
2241109-1	1990	One of the pathways of action of the differentiation-inducing agent DMF, in chemically transformed AKR-MCA fibroblastic cells, is through the concurrent restoration of the synthesis of the cell-surface adhesion molecule fibronectin and receptors for fibronectin.	Dimethylformamide	68-71	fibronectin 1	Mus musculus	220-231
2241109-1	1990	One of the pathways of action of the differentiation-inducing agent DMF, in chemically transformed AKR-MCA fibroblastic cells, is through the concurrent restoration of the synthesis of the cell-surface adhesion molecule fibronectin and receptors for fibronectin.	Dimethylformamide	68-71	fibronectin 1	Mus musculus	250-261
1965387-7	1990	Of particular interest is the fact that the distribution of microtubules, microfilaments and fibronectin were recovered after treatment with 1 mM db-cAMP for 6 days.	Bucladesine	146-153	fibronectin 1	Mus musculus	93-104
2387848-0	1990	Modulation of haptotactic migration of metastatic melanoma cells by the interaction between heparin and heparin-binding domain of fibronectin.	Heparin	92-99	fibronectin 1	Mus musculus	130-141
2387848-0	1990	Modulation of haptotactic migration of metastatic melanoma cells by the interaction between heparin and heparin-binding domain of fibronectin.	Heparin	104-111	fibronectin 1	Mus musculus	130-141
2387848-4	1990	At the same time, heparin or two monoclonal antibodies against the heparin-binding domain were able to inhibit the haptotactic migration to CH-271 or fibronectin, though not to C-274 or a mixture of C-274 and H-271.	Heparin	18-25	fibronectin 1	Mus musculus	150-161
2387848-6	1990	It seems likely that the regulatory mechanism may depend on interaction between heparin-like molecules on the cell surface and the heparin-binding domain in fibronectin, rather than on simple steric hindrance or on the masking of the cell-binding domain caused by the binding of heparin to heparin-binding domain.	Heparin	80-87	fibronectin 1	Mus musculus	157-168
2387848-6	1990	It seems likely that the regulatory mechanism may depend on interaction between heparin-like molecules on the cell surface and the heparin-binding domain in fibronectin, rather than on simple steric hindrance or on the masking of the cell-binding domain caused by the binding of heparin to heparin-binding domain.	Heparin	131-138	fibronectin 1	Mus musculus	157-168
2387848-6	1990	It seems likely that the regulatory mechanism may depend on interaction between heparin-like molecules on the cell surface and the heparin-binding domain in fibronectin, rather than on simple steric hindrance or on the masking of the cell-binding domain caused by the binding of heparin to heparin-binding domain.	Heparin	131-138	fibronectin 1	Mus musculus	157-168
2387848-6	1990	It seems likely that the regulatory mechanism may depend on interaction between heparin-like molecules on the cell surface and the heparin-binding domain in fibronectin, rather than on simple steric hindrance or on the masking of the cell-binding domain caused by the binding of heparin to heparin-binding domain.	Heparin	131-138	fibronectin 1	Mus musculus	157-168
7480211-0	1995	Effects of catechins on the mouse tumor cell adhesion to fibronectin.	Catechin	11-20	fibronectin 1	Mus musculus	57-68
2378936-6	1990	PAS were secreted during outgrowth on fibronectin-coated plastic in serum-free medium, but not by blastocysts held in a non-attachment state during culture in serum-free medium on uncoated plastic.	Protactinium	0-3	fibronectin 1	Mus musculus	38-49
2123807-2	1990	In this study, we analyzed the interactions of vinculin and fibronectin with plasma membrane proteins separated by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, and then transferred onto polyvinylidene-difluoride (PVDF) paper.	Sodium Dodecyl Sulfate	115-138	fibronectin 1	Mus musculus	60-71
2123807-2	1990	In this study, we analyzed the interactions of vinculin and fibronectin with plasma membrane proteins separated by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, and then transferred onto polyvinylidene-difluoride (PVDF) paper.	Sodium Dodecyl Sulfate	140-143	fibronectin 1	Mus musculus	60-71
2123807-2	1990	In this study, we analyzed the interactions of vinculin and fibronectin with plasma membrane proteins separated by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, and then transferred onto polyvinylidene-difluoride (PVDF) paper.	polyacrylamide	145-159	fibronectin 1	Mus musculus	60-71
1698194-0	1990	Inhibition of tumor angiogenesis by a synthetic cell-adhesive polypeptide containing the Arg-Gly-Asp (RGD) sequence of fibronectin, poly(RGD).	arginyl-glycyl-aspartic acid	89-100	fibronectin 1	Mus musculus	119-130
1698194-1	1990	We have investigated the anti-angiogenic effect of a polymeric peptide based on the Arg-Gly-Asp (RGD) core sequence of fibronectin as a monomer unit, i.e., poly(RGD), in syngeneic mice and in vitro.	Arginine	84-87	fibronectin 1	Mus musculus	119-130
1698194-1	1990	We have investigated the anti-angiogenic effect of a polymeric peptide based on the Arg-Gly-Asp (RGD) core sequence of fibronectin as a monomer unit, i.e., poly(RGD), in syngeneic mice and in vitro.	Aspartic Acid	92-95	fibronectin 1	Mus musculus	119-130
2119367-1	1990	We have investigated the anti-metastatic and anti-invasive activities of polypeptide analogues based on the Arg-Gly-Asp (RGD) adhesive signal in fibronectin, poly(RGD), poly(RGDS)[Arg-Gly-Asp-Ser] and poly(RGDT)[Arg-Gly-Asp-Thr].	arginyl-glycyl-aspartic acid	108-119	fibronectin 1	Mus musculus	145-156
2119367-1	1990	We have investigated the anti-metastatic and anti-invasive activities of polypeptide analogues based on the Arg-Gly-Asp (RGD) adhesive signal in fibronectin, poly(RGD), poly(RGDS)[Arg-Gly-Asp-Ser] and poly(RGDT)[Arg-Gly-Asp-Thr].	Arginine	108-111	fibronectin 1	Mus musculus	145-156
2119367-1	1990	We have investigated the anti-metastatic and anti-invasive activities of polypeptide analogues based on the Arg-Gly-Asp (RGD) adhesive signal in fibronectin, poly(RGD), poly(RGDS)[Arg-Gly-Asp-Ser] and poly(RGDT)[Arg-Gly-Asp-Thr].	Glycine	112-115	fibronectin 1	Mus musculus	145-156
2119367-1	1990	We have investigated the anti-metastatic and anti-invasive activities of polypeptide analogues based on the Arg-Gly-Asp (RGD) adhesive signal in fibronectin, poly(RGD), poly(RGDS)[Arg-Gly-Asp-Ser] and poly(RGDT)[Arg-Gly-Asp-Thr].	Aspartic Acid	116-119	fibronectin 1	Mus musculus	145-156
2100902-0	1990	Effect of mannozym treatment on plasma fibronectin concentration in germfree and conventional mice.	mannozym	10-18	fibronectin 1	Mus musculus	39-50
2100902-1	1990	As a result of a single intraperitoneal treatment with 1 mg/ml of Mannozym (M) the plasma fibronectin (FN) level was significantly increased both in germfree (Gf) and conventional (Cv) mice, and though it started from a lower value in Gf mice, it rose to a similar level to that of Cv animals.	mannozym	66-74	fibronectin 1	Mus musculus	90-101
2100902-1	1990	As a result of a single intraperitoneal treatment with 1 mg/ml of Mannozym (M) the plasma fibronectin (FN) level was significantly increased both in germfree (Gf) and conventional (Cv) mice, and though it started from a lower value in Gf mice, it rose to a similar level to that of Cv animals.	mannozym	66-74	fibronectin 1	Mus musculus	103-105
34852206-7	2022	During 3-months of tungsten exposure, murine kidneys demonstrated significant increases in the myofibroblast marker  SMA, and extracellular matrix products: fibronectin, collagen, and matricellular proteins.	Tungsten	19-27	fibronectin 1	Mus musculus	157-168
2007184-5	1991	Instead, S115 cells growth without testosterone showed epithelial morphology and binding to the heparin-binding domain of FN, suggesting an alteration of syndecan expression in hormone-treated S115 cells.	Testosterone	35-47	fibronectin 1	Mus musculus	122-124
2007184-5	1991	Instead, S115 cells growth without testosterone showed epithelial morphology and binding to the heparin-binding domain of FN, suggesting an alteration of syndecan expression in hormone-treated S115 cells.	Heparin	96-103	fibronectin 1	Mus musculus	122-124
2123807-2	1990	In this study, we analyzed the interactions of vinculin and fibronectin with plasma membrane proteins separated by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, and then transferred onto polyvinylidene-difluoride (PVDF) paper.	polyvinylidene fluoride	234-238	fibronectin 1	Mus musculus	60-71
2141611-1	1990	In previous studies it was shown that transformation of AKR fibroblasts with 3-methylcholanthrene was associated with a loss of surface fibronectin and that induction of differentiation of the transformed cells with N,N-dimethylformamide (DMF) was associated with reacquisition of surface fibronectin (Chakrabarty et al., J.	Methylcholanthrene	77-97	fibronectin 1	Mus musculus	136-147
2141611-1	1990	In previous studies it was shown that transformation of AKR fibroblasts with 3-methylcholanthrene was associated with a loss of surface fibronectin and that induction of differentiation of the transformed cells with N,N-dimethylformamide (DMF) was associated with reacquisition of surface fibronectin (Chakrabarty et al., J.	Methylcholanthrene	77-97	fibronectin 1	Mus musculus	289-300
2141611-1	1990	In previous studies it was shown that transformation of AKR fibroblasts with 3-methylcholanthrene was associated with a loss of surface fibronectin and that induction of differentiation of the transformed cells with N,N-dimethylformamide (DMF) was associated with reacquisition of surface fibronectin (Chakrabarty et al., J.	Dimethylformamide	216-237	fibronectin 1	Mus musculus	289-300
2141611-1	1990	In previous studies it was shown that transformation of AKR fibroblasts with 3-methylcholanthrene was associated with a loss of surface fibronectin and that induction of differentiation of the transformed cells with N,N-dimethylformamide (DMF) was associated with reacquisition of surface fibronectin (Chakrabarty et al., J.	Dimethylformamide	239-242	fibronectin 1	Mus musculus	289-300
2141611-11	1990	Antibodies to the fibronectin receptor isolated from human placenta reacted with the DMF-sensitive moieties in immunoblot assays.	Dimethylformamide	85-88	fibronectin 1	Mus musculus	18-29
2141611-12	1990	Both the appearance of the fibronectin binding moieties and the acquisition of 125I-fibronectin binding activity by whole cells occurred within 6 hr of DMF treatment and increased over the subsequent 4 day period.	Dimethylformamide	152-155	fibronectin 1	Mus musculus	27-38
2141611-12	1990	Both the appearance of the fibronectin binding moieties and the acquisition of 125I-fibronectin binding activity by whole cells occurred within 6 hr of DMF treatment and increased over the subsequent 4 day period.	Dimethylformamide	152-155	fibronectin 1	Mus musculus	84-95
2141611-13	1990	The time course of these events paralleled closely the time course for induction of fibronectin biosynthesis by DMF.	Dimethylformamide	112-115	fibronectin 1	Mus musculus	84-95
2335442-0	1990	Laminin and fibronectin in retinoid-induced keratolenticular dysgenesis.	Retinoids	27-35	fibronectin 1	Mus musculus	12-23
33779314-5	2021	Pathway enrichment findings showed integrin beta- and fibronectin-encoding genes had distinct expression within the integrin-linked kinase signaling pathway which were up-regulated in 0.2% adenine-fed leptospira-infected mice but not in 0.2% adenine-fed mice, indicating background subclinical leptospiral infection indeed enhanced subsequent secondary nephrotoxic kidney injury and potential pathogenic molecules associated with secondary nephrotoxic leptospirosis.	Adenine	189-196	fibronectin 1	Mus musculus	54-65
33779314-5	2021	Pathway enrichment findings showed integrin beta- and fibronectin-encoding genes had distinct expression within the integrin-linked kinase signaling pathway which were up-regulated in 0.2% adenine-fed leptospira-infected mice but not in 0.2% adenine-fed mice, indicating background subclinical leptospiral infection indeed enhanced subsequent secondary nephrotoxic kidney injury and potential pathogenic molecules associated with secondary nephrotoxic leptospirosis.	Adenine	242-249	fibronectin 1	Mus musculus	54-65
7480211-1	1995	We studied the effects of 5 kinds of catechins on the adhesion of mouse lung carcinoma 3LL and melanoma B16F10 cells to the fibronectin substratum.	Catechin	37-46	fibronectin 1	Mus musculus	124-135
34224844-4	2021	Mechanistic investigation in mesangial cells revealed that high glucose decreased the expression of deptor concomitant with increased mTORC1 and mTORC2 activities, induction of hypertrophy and, expression of fibronectin and PAI-1.	Glucose	64-71	fibronectin 1	Mus musculus	208-219
34420157-4	2021	ATN-161 treatment (10 microM) effectively inhibited OGD/R-induced extracellular matrix (ECM) deposition by reducing integrin alpha5, MMP-9, and fibronectin expression, as well as reducing oxidative stress by reducing mitochondrial superoxide radicals, intracellular ROS, inflammation by reducing NLRP3 inflammasome, tight junction loss by reducing claudin-5 and ZO-1 expression levels, mitochondrial damage by inhibiting mitochondrial depolarization, and apoptosis via regulation of p-FAK and p-AKT levels.	acetyl-prolyl-histidyl-seryl-cysteinyl-asparaginamide	0-7	fibronectin 1	Mus musculus	144-155
34959755-10	2021	Nevertheless, butyrate lowered the fibrotic response of PCLSs, as shown by reduced gene expression of fibronectin, alpha-smooth muscle actin and osteopontin, and protein levels of type I collagen.	Butyrates	14-22	fibronectin 1	Mus musculus	102-113
34880752-6	2021	Tetrandrine decreased TGF-beta1-induced expression of alpha-smooth muscle actin, fibronectin, vimentin, and type 1 collagen and proliferation in fibroblasts.	tetrandrine	0-11	fibronectin 1	Mus musculus	81-92
34916195-8	2021	RESULTS: In the hemisection injury model, fibroblasts recruitment and fibronectin deposition in the injured area was significantly reduced and the neurological function was improved in 1D11 treatment group as compared with those in 13C4-treated group (P < 0.05).	13c4	232-236	fibronectin 1	Mus musculus	70-81
34176379-6	2021	Ang II increased the expression of inflammatory cytokines tumor necross factor alpha and interleukin 1 beta and profibrotic factors transforming growth factor beta 1 and fibronectin in the heart, with was reduced by LEC treatment.	4-NITROPHENYL-N-ACETYL-BETA-D-GLUCOSAMINIDE	216-219	fibronectin 1	Mus musculus	170-181
34779414-9	2021	Furthermore, candesartan reduced the mRNA expression of Fn1, Ltbp-4, and Adamtsl2, which are involved in forming the extracellular matrix network.	candesartan	13-24	fibronectin 1	Mus musculus	56-59
34480883-6	2021	UUO induced histological alterations, accumulation of extracellular matrix (ECM) components including collagens, fibronectin, and alpha-smooth muscle actin (alpha-SMA), activation of the transforming growth factor-beta (TGF-beta)/Smad signaling and oxidative damage in the obstructed kidneys.	uuo	0-3	fibronectin 1	Mus musculus	113-124
34656882-7	2021	In addition, CAL SN38 NP treatment significantly decreased the expression of N-cadherin, collagen, and fibronectin in tumors, which play critical roles in PDAC metastasis.	sn38 np	17-24	fibronectin 1	Mus musculus	103-114
34656882-7	2021	In addition, CAL SN38 NP treatment significantly decreased the expression of N-cadherin, collagen, and fibronectin in tumors, which play critical roles in PDAC metastasis.	pdac	155-159	fibronectin 1	Mus musculus	103-114
34592488-13	2021	MCD also induced rising expression of typical genes and proteins related to fibrosis (fibronectin, alpha-SMA, collagens, TGF-beta) and inflammation (ILs, TNF-alpha, MCP-1), which was suppressed by low-dose triptolide.	triptolide	206-216	fibronectin 1	Mus musculus	86-97
34805020-11	2021	COL-1A and fibronectin expressions were significantly increased by alcohol treatment.	Alcohols	67-74	fibronectin 1	Mus musculus	11-22
34805020-12	2021	Alcohol with LPS treatment significantly increased COL-1A and fibronectin expressions more than alcohol alone treatment.	Alcohols	0-7	fibronectin 1	Mus musculus	62-73
34805020-12	2021	Alcohol with LPS treatment significantly increased COL-1A and fibronectin expressions more than alcohol alone treatment.	Alcohols	96-103	fibronectin 1	Mus musculus	62-73
34805020-13	2021	Alcohol with CCL4 treatment significantly increased COL-1A and fibronectin expressions more than alcohol alone treatment.	Alcohols	0-7	fibronectin 1	Mus musculus	63-74
34805020-13	2021	Alcohol with CCL4 treatment significantly increased COL-1A and fibronectin expressions more than alcohol alone treatment.	Alcohols	97-104	fibronectin 1	Mus musculus	63-74
34805020-14	2021	Alcohol with LPS and CCL4 treatment increased COL-1A and fibronectin expressions more than alcohol with CCL4 treatment, but it was not statistically significant.	Alcohols	0-7	fibronectin 1	Mus musculus	57-68
34915776-9	2021	In addition, norgalanthamine decreased collagen deposition in liver tissue as shown on picrosirius red staining by down-regulating expression of the fibrosis-related genes alphaSMA and fibronectin.	norgalanthamine	13-28	fibronectin 1	Mus musculus	185-196
34375673-5	2021	Ang II increased the protein expression levels of c-Myc, cyclin D1, fibronectin, vimentin, alphaSMA and Snail, and the treatment with the Ang II type 1 receptor blocker valsartan significantly suppressed the Ang II-induced increases of fibronectin and vimentin.	Valsartan	169-178	fibronectin 1	Mus musculus	68-79
34375673-5	2021	Ang II increased the protein expression levels of c-Myc, cyclin D1, fibronectin, vimentin, alphaSMA and Snail, and the treatment with the Ang II type 1 receptor blocker valsartan significantly suppressed the Ang II-induced increases of fibronectin and vimentin.	Valsartan	169-178	fibronectin 1	Mus musculus	236-247
34224844-9	2021	Moreover, expression of hyperactive mTORC1 reversed shEZH2-mediated inhibition of hypertrophy and expression of fibronectin and PAI-1 by high glucose.	Glucose	142-149	fibronectin 1	Mus musculus	112-123
34315630-8	2021	This was due to the fact that 2-APB restrained the expression fibrotic markers, alpha-SMA, fibronectin and vimentin through inhibiting TGF-beta1/SMAD3 signaling.	2-aminoethyl diphenylborinate	30-35	fibronectin 1	Mus musculus	91-102
34118645-3	2021	Treatment with DHL significantly reduced pathological injury and fibrosis, the secretion of BLM-induced pro-fibrotic mediators TGF-beta and alpha-SMA, and components of the extracellular matrix (fibronectin).	dehydrocostus lactone	15-18	fibronectin 1	Mus musculus	195-206
34502355-4	2021	Cardiac fibrosis was noted histologically and mRNA levels of collagen 1alpha, collagen 3alpha and fibronectin 1 were augmented in DT.	Thymidine	130-132	fibronectin 1	Mus musculus	98-111
34422811-7	2021	Results: Overexpression of lncRNA TPA decreased the expression of E-cadherin, and significantly increased the expression of Vimentin, fibronectin and TGF-beta1 (p < 0.01), and increased the migration rate, migration ability and invasion ability of cell group (P < 0.01).	Tetradecanoylphorbol Acetate	34-37	fibronectin 1	Mus musculus	134-145
34153226-5	2021	Non-cytotoxic concentrations of AGEs upregulated the protein expression of fibronectin, vimentin, and alpha-smooth muscle actin (alpha-SMA) (mesenchymal/myofibroblast markers) and downregulated the protein expression of vascular endothelial (VE)-cadherin and cluster of differentiation (CD) 31 (endothelial cell markers) in cultured mouse pancreatic islet endothelial cells, which was prevented by the AGE cross-link breaker alagebrium chloride.	alagebrium	425-444	fibronectin 1	Mus musculus	75-86
34439556-10	2021	In SMC, BGP increased Collagen I and fibronectin expression by priming ROS production and NFkappaB activity.	ros	71-74	fibronectin 1	Mus musculus	37-48
34445540-8	2021	HCl equally provoked the deposition of collagen and fibronectin; however, significant age-dependent differences were observed in the increase in elastin and tenascin C mRNA.	Hydrochloric Acid	0-3	fibronectin 1	Mus musculus	52-63
34400742-5	2021	At the molecular level, paricalcitol treatment suppressed the induction of fibrotic inducer TGF-beta and extracellular matrix proteins alpha-SMA, collagen type I and fibronectin in the lung, whereas vitamin D deficiency exacerbated the induction of these proteins.	paricalcitol	24-36	fibronectin 1	Mus musculus	166-177
34316030-5	2022	We found that pirfenidone alleviated silica-induced lung dysfunction, secretion of inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and deposition of fibrotic proteins (collagen I and fibronectin) in both early and advanced silicosis models.	pirfenidone	14-25	fibronectin 1	Mus musculus	186-197
35304156-9	2022	Overexpression of nicotinamide adenine dinucleotide phosphate oxidases (Nox1) reversed the attenuating influences of FGF12 on the enhancements of collagen I, collagen III and fibronectin in the CFs induced by Ang II.	nicotinamide adenine	18-38	fibronectin 1	Mus musculus	175-186
34118180-11	2021	Both TMEM16A inhibitor and NaHS reversed these signaling events and prevented changes in fibronectin and SASP.	sodium bisulfide	27-31	fibronectin 1	Mus musculus	89-100
34188444-11	2021	In addition, curcumol attenuated the up-regulated expressions of beta-catenin, Wnt5a, VEGFA, TGF-beta1, Fibronectin, and MMP-9 in the lung tissues of chronic asthmatic mice, but curcumol treatment did not show such effects on healthy mice.	curcumol	13-21	fibronectin 1	Mus musculus	104-115
35560511-10	2022	At molecular level, nicotine suppressed let-7c-5p, while induced NGF, FN1, and COLIA levels.	Nicotine	20-28	fibronectin 1	Mus musculus	70-73
35550189-5	2022	In a model of primary cultured murine adipose progenitors, we found that exposure to beta-hydroxybutyrate selectively reduced Tgfbeta-dependent profibrotic responses of ECM genes like Ctgf, Loxl2 and Fn1.	3-Hydroxybutyric Acid	85-105	fibronectin 1	Mus musculus	200-203
34061176-12	2021	Down-regulation of Smurf1 resulted in suppression of hypoxia-induced fibronectin expression, whereas treatment with cMet Ab showed synergistic effects.	cmet ab	116-123	fibronectin 1	Mus musculus	69-80
34130288-15	2021	On top of that, PGE2 administration revealed inhibited IDO expression and that reducing GSK-3beta and beta-catenin resulting in lower expressions of alpha-SMA, fibronectin, and vimentin in WT AKI mice.	Dinoprostone	16-20	fibronectin 1	Mus musculus	160-171
34195593-4	2021	Specifically, we hypothesized that alphavbeta3 integrin engagement on fibronectin induces pericyte transition into myofibroblastic phenotypes in the murine bleomycin lung injury model.	Bleomycin	156-165	fibronectin 1	Mus musculus	70-81
35247475-10	2022	RESULTS: FTZ effectively decreased 24 h proteinuria, Scr, FBG, TC, TG, and LDL-C levels, inhibited mesangial cell expansion, reduced FN and collagen IV accumulation, and F4/80+ macrophage cell infiltration and Ly-6G+ neutrophil infiltration in glomerulus and tubulointerstitium.	CHEMBL1354522	9-12	fibronectin 1	Mus musculus	133-135
35618653-0	2022	A ROS-Responsive Simvastatin Nano-Prodrug and its Fibronectin-Targeted Co-Delivery System for Atherosclerosis Treatment.	Simvastatin	17-28	fibronectin 1	Mus musculus	50-61
35618653-5	2022	Moreover, by taking advantage of the self-assembly behavior of TPTS, we developed a fibronectin-targeted delivery system (TPTS/C/T) to codelivery simvastatin prodrug and ticagrelor.	Simvastatin	146-157	fibronectin 1	Mus musculus	84-95
35513128-7	2022	Besides, Daph significantly inhibited the TAC-induced accumulation of ECM components, including alpha-smooth muscle actin (alpha-SMA), collagen I, collagen III, and fibronectin, and interfered with the TGF-beta1/Smad2/3 signaling axis.	daphnetin	9-13	fibronectin 1	Mus musculus	165-176
35513128-7	2022	Besides, Daph significantly inhibited the TAC-induced accumulation of ECM components, including alpha-smooth muscle actin (alpha-SMA), collagen I, collagen III, and fibronectin, and interfered with the TGF-beta1/Smad2/3 signaling axis.	tac	42-45	fibronectin 1	Mus musculus	165-176
35535385-17	2022	MiR-1278 targeted FN1, and silencing FN1 neutralized the effects of miR-1278 inhibitors on GC progression.	mir-1278	0-8	fibronectin 1	Mus musculus	18-21
35426327-7	2022	Furthermore, in a transforming growth factor (TGF)-beta1-induced renal fibrosis cell model, icariin treatment also decreased fibronectin, type I collagen and alpha-SMA expression.	icariin	92-99	fibronectin 1	Mus musculus	125-136
35625934-10	2022	Repetitive treatment with 100 mg diclofenac over three days aggravated renal injury and caused upregulation of the pro-fibrotic marker fibronectin in the setting of subclinical AKI, but not in sham control kidneys.	Diclofenac	33-43	fibronectin 1	Mus musculus	135-146
35349832-7	2022	RESULTS: Capsaicin treatment significantly alleviated fibronectin and collagen depositions in the tubulointerstitium of the injured kidneys from UUO and adenine-fed mice.	Capsaicin	9-18	fibronectin 1	Mus musculus	54-65
35349832-7	2022	RESULTS: Capsaicin treatment significantly alleviated fibronectin and collagen depositions in the tubulointerstitium of the injured kidneys from UUO and adenine-fed mice.	uuo	145-148	fibronectin 1	Mus musculus	54-65
35602095-0	2022	Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway.	Adenosine Monophosphate	111-114	fibronectin 1	Mus musculus	12-25
35367419-8	2022	The regulatory role of GA in downregulating Col I, Col III, fibronectin in NRCFs, and enhancing levels of ANP, BNP and beta-MHC in NRCMs were reversed by MMP9 overexpression, so as the downregulation of IL-1beta, IL-6 and TNF-alpha in Ang II-induced NRCFs and NRCMs.	ginkgolide A	23-25	fibronectin 1	Mus musculus	60-71
35538534-6	2022	SV40 MES13 cells were treated with LPA in the presence or absence of ki16425, and the expression of ChREBP and fibrotic factors, including fibronectin, TGF-beta, and IL-1beta, was examined.	lysophosphatidic acid	35-38	fibronectin 1	Mus musculus	139-150
35338010-11	2022	miR-122 expression WAS reduced by 0.21-fold and serum ALT and AST levels were enhanced in mice following 8-week CCl4 induction along with increased expression of FN, alpha-SMA, and Collagen I in liver tissues, which was blocked by miR-122 overexpression.	Carbon Tetrachloride	112-116	fibronectin 1	Mus musculus	162-164
35538534-11	2022	Treatment with LPA induced the expression of ChREBP and fibrotic factors, including fibronectin, TGF-beta, and IL-1beta, in SV40 MES13 cells, which were positively correlated.	lysophosphatidic acid	15-18	fibronectin 1	Mus musculus	84-95
35397105-9	2022	The ELISA and qPCR results showed that the inflammatory cytokines (TNF-alpha and IL-1beta) and ECM (collagen I, collagen IV, fibronectin, and laminin) were increased with ROS increasing, which was induced by Se deficiency.	Reactive Oxygen Species	171-174	fibronectin 1	Mus musculus	125-136
35485286-6	2022	Knockdown of CCL20 suppressed lead acetate-induced fibroblast proliferation, hydroxyproline contents, transforming growth factor-beta production and ECM-related protein (Collagen I and fibronectin) expression.	lead acetate	30-42	fibronectin 1	Mus musculus	185-196
35578666-11	2022	Knockdown of FN1, COL1A1, and COL1A2 enhanced the cell proliferation and migration of U2OS under the restriction of cisplatin.	Cisplatin	116-125	fibronectin 1	Mus musculus	13-16
35578666-12	2022	Our findings revealed the common oncogenic genes such as FN1, COL1A1, and COL1A2, which may act as antioncogene by enhancing cisplatin sensitivity in osteosarcoma cells, and pathways were both in osteosarcoma and Ewing"s sarcoma.	Cisplatin	125-134	fibronectin 1	Mus musculus	57-60
35385768-10	2022	Treatment with the ERK 1/2 inhibitor U0126 partially prevented the induction of fibronectin in response to LPA, suggesting that this pathway is involved in LPA-induced fibrosis.	U 0126	37-42	fibronectin 1	Mus musculus	80-91
35385768-10	2022	Treatment with the ERK 1/2 inhibitor U0126 partially prevented the induction of fibronectin in response to LPA, suggesting that this pathway is involved in LPA-induced fibrosis.	lysophosphatidic acid	107-110	fibronectin 1	Mus musculus	80-91
35385768-10	2022	Treatment with the ERK 1/2 inhibitor U0126 partially prevented the induction of fibronectin in response to LPA, suggesting that this pathway is involved in LPA-induced fibrosis.	lysophosphatidic acid	156-159	fibronectin 1	Mus musculus	80-91
35451372-5	2022	By increasing intracellular calcium, mechanical stress or the Piezo1 agonist Yoda1-activated PSCs manifest by loss of perinuclear fat droplets and increased TGF-beta1, fibronectin, and type I collagen expression.	Calcium	28-35	fibronectin 1	Mus musculus	168-179
35263095-3	2022	cRGD and cCLT1 peptides, which could target the integrin and fibronectin, respectively, overexpressed in pancreatic cancer cells and stroma, were decorated on PTX-loaded microbubbles, resulting in the formation of dual-targeting PTX-RCMBs.	Paclitaxel	159-162	fibronectin 1	Mus musculus	61-72
35263095-3	2022	cRGD and cCLT1 peptides, which could target the integrin and fibronectin, respectively, overexpressed in pancreatic cancer cells and stroma, were decorated on PTX-loaded microbubbles, resulting in the formation of dual-targeting PTX-RCMBs.	Paclitaxel	229-232	fibronectin 1	Mus musculus	61-72
35263095-5	2022	Then, the cCLT1 peptide modified on PTX-RCNPs selectively bound the fibronectin highly expressed in the stroma and later targeted the integrin (alpha5beta1) on the cell surface.	Paclitaxel	36-39	fibronectin 1	Mus musculus	68-79
35273174-4	2022	Here, we present a simple yet effective approach to single-cell arraying based on a graphene oxide (GO) surface carrying protein (fibronectin) microarrays to define cell adhesion points.	graphene oxide	84-98	fibronectin 1	Mus musculus	130-141
35274959-3	2022	Here, we investigate the hydrogelation behavior of a designed decapeptide containing a tetraleucine self-assembling backbone and fibronectin-related tripeptides near both ends of the strand.	tripeptides	149-160	fibronectin 1	Mus musculus	129-140
35273174-4	2022	Here, we present a simple yet effective approach to single-cell arraying based on a graphene oxide (GO) surface carrying protein (fibronectin) microarrays to define cell adhesion points.	graphene oxide	100-102	fibronectin 1	Mus musculus	130-141
35250392-16	2022	LC-MS/MS primarily identified fibronectin in necrotic cells as a putative high fidelity target of glucaric acid.	Glucaric Acid	98-111	fibronectin 1	Mus musculus	30-41
35097132-7	2022	Clodronate treatment prevented the alteration in cytokines, TNFalpha and IL-6, and increase in gene expression of connective tissue growth factor (CTGF), TGFbeta-1, matrix metalloproteinase-9 (MMP9), fibronectin, laminin, and collagen in FHKO mice with CSS (P < 0.05).	Clodronic Acid	0-10	fibronectin 1	Mus musculus	200-211
35191964-12	2022	HL3501 and latanoprost also inhibited fibronectin and alpha-smooth muscle actin expression induced by Dex treatment.	Latanoprost	11-22	fibronectin 1	Mus musculus	38-49
35191964-12	2022	HL3501 and latanoprost also inhibited fibronectin and alpha-smooth muscle actin expression induced by Dex treatment.	Dexamethasone	102-105	fibronectin 1	Mus musculus	38-49
35053535-0	2022	BHMPS Inhibits Breast Cancer Migration and Invasion by Disrupting Rab27a-Mediated EGFR and Fibronectin Secretion.	bhmps	0-5	fibronectin 1	Mus musculus	91-102
35053535-6	2022	BHMPS decreased the secretion of epidermal growth factor receptor and fibronectin by interfering with vesicle trafficking, as indicated by increased perinuclear accumulation of CD63-positive vesicles.	bhmps	0-5	fibronectin 1	Mus musculus	70-81
35187969-7	2022	Moreover, it was found that ALA downregulated the mRNA expressions of alpha-smooth muscle actin (alpha-SMA), collagen type I and fibronectin in the skin tissue of the BLM group.	Thioctic Acid	28-31	fibronectin 1	Mus musculus	129-140
35355726-4	2022	We showed that ACPA treatment significantly improved the survival rate of BLM-treated mice, alleviated BLM-induced pulmonary fibrosis, and inhibited the expressions of extracellular matrix (ECM) markers, such as collagen, fibronectin, and alpha-SMA.	arachidonylcyclopropylamide	15-19	fibronectin 1	Mus musculus	222-233
2736523-1	1989	We investigated that the antimetastatic and antiadhesive activities of peptides based on Arg-Gly-Asp adhesive signal in fibronectin could be augmented by their polymerization.	Arginine	89-92	fibronectin 1	Mus musculus	120-131
2758412-11	1989	The results demonstrated that a serine containing RGD-related peptide (GRGDSP) has virtually no effect on melanoma cell adhesion on type IV collagen-coated substrata, whereas this peptide inhibited melanoma cell adhesion to fibronectin-coated substrata in a concentration-dependent manner.	Serine	32-38	fibronectin 1	Mus musculus	224-235
2503446-4	1989	The tetrapeptide arginine-glycine-aspartic acid-serine, which comprises the eucaryotic cell-binding domain of fibronectin, was also capable of promoting bacterial uptake, whereas the control tetrapeptide tetraglycine was not.	arginine-glycine	17-33	fibronectin 1	Mus musculus	110-121
2503446-4	1989	The tetrapeptide arginine-glycine-aspartic acid-serine, which comprises the eucaryotic cell-binding domain of fibronectin, was also capable of promoting bacterial uptake, whereas the control tetrapeptide tetraglycine was not.	aspartic acid-serine	34-54	fibronectin 1	Mus musculus	110-121
2503446-4	1989	The tetrapeptide arginine-glycine-aspartic acid-serine, which comprises the eucaryotic cell-binding domain of fibronectin, was also capable of promoting bacterial uptake, whereas the control tetrapeptide tetraglycine was not.	glycyl-glycyl-glycyl-glycine	204-216	fibronectin 1	Mus musculus	110-121
2532538-1	1989	Swiss mouse 3T3 cells, when grown in the presence of 5 mM chlorate, an inhibitor of PAPS synthesis, produce heparan sulfate glycosaminoglycan chains containing only about 8% of the sulfate normally present and which have lost the ability to bind to fibronectin.	Chlorates	58-66	fibronectin 1	Mus musculus	249-260
2489085-1	1989	Anti-cell adhesive activity was examined by the synthetic polypeptide, containing repetitive Arg-Gly-Asp sequence of cell attachment site from fibronectin, poly (Arg-Gly-Asp).	Arginine	93-96	fibronectin 1	Mus musculus	143-154
2489085-1	1989	Anti-cell adhesive activity was examined by the synthetic polypeptide, containing repetitive Arg-Gly-Asp sequence of cell attachment site from fibronectin, poly (Arg-Gly-Asp).	Glycine	97-100	fibronectin 1	Mus musculus	143-154
2489085-1	1989	Anti-cell adhesive activity was examined by the synthetic polypeptide, containing repetitive Arg-Gly-Asp sequence of cell attachment site from fibronectin, poly (Arg-Gly-Asp).	Aspartic Acid	101-104	fibronectin 1	Mus musculus	143-154
2489085-1	1989	Anti-cell adhesive activity was examined by the synthetic polypeptide, containing repetitive Arg-Gly-Asp sequence of cell attachment site from fibronectin, poly (Arg-Gly-Asp).	poly	58-62	fibronectin 1	Mus musculus	143-154
2489085-1	1989	Anti-cell adhesive activity was examined by the synthetic polypeptide, containing repetitive Arg-Gly-Asp sequence of cell attachment site from fibronectin, poly (Arg-Gly-Asp).	arginyl-glycyl-aspartic acid	93-104	fibronectin 1	Mus musculus	143-154
2489085-2	1989	The attachment of tumour cells to fibronectin substrate was specifically inhibited by adding poly (Arg-Gly-Asp) in cell surface receptor-mediated and divalent cation-dependent manners, but not by unrelated peptides.	poly (arginyl-glycyl-aspartic acid)	93-110	fibronectin 1	Mus musculus	34-45
2736523-1	1989	We investigated that the antimetastatic and antiadhesive activities of peptides based on Arg-Gly-Asp adhesive signal in fibronectin could be augmented by their polymerization.	Glycine	93-96	fibronectin 1	Mus musculus	120-131
2736523-1	1989	We investigated that the antimetastatic and antiadhesive activities of peptides based on Arg-Gly-Asp adhesive signal in fibronectin could be augmented by their polymerization.	Aspartic Acid	97-100	fibronectin 1	Mus musculus	120-131
2736523-3	1989	The adhesion of tumor cells to fibronectin was specifically inhibited by adding poly(Arg-Gly-Asp) but not unrelated peptides.	poly (arginyl-glycyl-aspartic acid)	80-96	fibronectin 1	Mus musculus	31-42
2736628-4	1989	Both TGF-beta 1-induced and basal levels of fibronectin were completely abolished by cycloheximide, suggesting that protein synthesis was required.	Cycloheximide	85-98	fibronectin 1	Mus musculus	44-55
2523953-2	1989	Human fibronectin receptor (VLA-5) alpha and beta chain probes were used to identify their mouse homologues in a thioglycollate-elicited peritoneal exudate cell cDNA library.	Thioglycolates	113-127	fibronectin 1	Mus musculus	6-17
2613755-2	1989	Both control cells grown to subconfluence and cells treated with 10(-6) M-retinoic acid adhered and spread rapidly on fibronectin (greater than 75% following 1 h of incubation) but adhered poorly to type I collagen (less than 15%).	Tretinoin	74-87	fibronectin 1	Mus musculus	118-129
2522738-6	1989	A competitive blocker of cell membrane fibronectin receptors, oligopeptide (Gly-Arg-Gly-Asp-Ser), inhibited mouse embryo development in a dose-dependent manner.	glycyl-arginyl-glycyl-aspartyl-serine	76-95	fibronectin 1	Mus musculus	39-50
2709334-7	1989	The ratio of fibronectin mRNA to polyadenylated RNA was elevated to a similar extent in both murine strains during the 1st week after cyclophosphamide treatment.	Cyclophosphamide	134-150	fibronectin 1	Mus musculus	13-24
2707186-5	1989	Thioglycollate-induced activated mouse peritoneal macrophages secreted significantly less fibronectin than resident peritoneal macrophages, a finding contrasting with those of Tsukamoto et al.	Thioglycolates	0-14	fibronectin 1	Mus musculus	90-101
2706569-5	1989	Antibodies against the fibronectin receptor of CHO fibroblasts and short peptides containing the Arg-Gly-Asp sequence greatly reduced PGC adhesion to fibronectin.	Arginine	97-100	fibronectin 1	Mus musculus	23-34
2706569-5	1989	Antibodies against the fibronectin receptor of CHO fibroblasts and short peptides containing the Arg-Gly-Asp sequence greatly reduced PGC adhesion to fibronectin.	Arginine	97-100	fibronectin 1	Mus musculus	150-161
2706569-5	1989	Antibodies against the fibronectin receptor of CHO fibroblasts and short peptides containing the Arg-Gly-Asp sequence greatly reduced PGC adhesion to fibronectin.	Glycine	101-104	fibronectin 1	Mus musculus	23-34
2706569-5	1989	Antibodies against the fibronectin receptor of CHO fibroblasts and short peptides containing the Arg-Gly-Asp sequence greatly reduced PGC adhesion to fibronectin.	Glycine	101-104	fibronectin 1	Mus musculus	150-161
2706569-5	1989	Antibodies against the fibronectin receptor of CHO fibroblasts and short peptides containing the Arg-Gly-Asp sequence greatly reduced PGC adhesion to fibronectin.	Aspartic Acid	105-108	fibronectin 1	Mus musculus	23-34
2706569-5	1989	Antibodies against the fibronectin receptor of CHO fibroblasts and short peptides containing the Arg-Gly-Asp sequence greatly reduced PGC adhesion to fibronectin.	Aspartic Acid	105-108	fibronectin 1	Mus musculus	150-161
2492204-4	1989	In parallel with these results both TPA and 12(S)-HETE [but not 12(R)-HETE] enhance tumor cell adhesion to endothelial cells, subendothelial matrix and fibronectin, but not to type IV collagen.	Tetradecanoylphorbol Acetate	36-39	fibronectin 1	Mus musculus	152-163
2492204-4	1989	In parallel with these results both TPA and 12(S)-HETE [but not 12(R)-HETE] enhance tumor cell adhesion to endothelial cells, subendothelial matrix and fibronectin, but not to type IV collagen.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	44-54	fibronectin 1	Mus musculus	152-163
2492204-7	1989	In contrast, a lipoxygenase product of linoleic acid, 13(S)-hydroxyoctadecadienoic acid, inhibited TPA and 12(S)-HETE-enhanced tumor cell adhesion to endothelial cells, subendothelial matrix, and fibronectin.	Linoleic Acid	39-52	fibronectin 1	Mus musculus	196-207
2492204-7	1989	In contrast, a lipoxygenase product of linoleic acid, 13(S)-hydroxyoctadecadienoic acid, inhibited TPA and 12(S)-HETE-enhanced tumor cell adhesion to endothelial cells, subendothelial matrix, and fibronectin.	13-hydroxy-9,11-octadecadienoic acid	54-87	fibronectin 1	Mus musculus	196-207
2492204-7	1989	In contrast, a lipoxygenase product of linoleic acid, 13(S)-hydroxyoctadecadienoic acid, inhibited TPA and 12(S)-HETE-enhanced tumor cell adhesion to endothelial cells, subendothelial matrix, and fibronectin.	Tetradecanoylphorbol Acetate	99-102	fibronectin 1	Mus musculus	196-207
2713979-4	1989	Immobilized leupeptin, L-lysine, or D-Phe-Pro-Arg-chloromethyl ketone can also direct outgrowth towards their immobilized areas, as do zones of laminin or fibronectin.	leupeptin	12-21	fibronectin 1	Mus musculus	155-166
2714513-3	1989	Sialylated polylactosamine-containing beta 1-6-branched oligosaccharides on proteins such as P2B and fibronectin may reduce cell adhesion and enhance tumour cell invasion.	polylactosamine	11-26	fibronectin 1	Mus musculus	101-112
2714513-3	1989	Sialylated polylactosamine-containing beta 1-6-branched oligosaccharides on proteins such as P2B and fibronectin may reduce cell adhesion and enhance tumour cell invasion.	beta 1-6-branched oligosaccharides	38-72	fibronectin 1	Mus musculus	101-112
2535959-5	1989	Both antibodies also reacted with an integrin-related fibronectin-binding receptor complex purified by ligand affinity chromatography on fibronectin-Sepharose columns.	Sepharose	149-158	fibronectin 1	Mus musculus	54-65
2535959-5	1989	Both antibodies also reacted with an integrin-related fibronectin-binding receptor complex purified by ligand affinity chromatography on fibronectin-Sepharose columns.	Sepharose	149-158	fibronectin 1	Mus musculus	137-148
2521609-3	1989	After trypsinization, binding of 125I-labeled plasma fibronectin (125I-pFN) to the macrophage monolayer was increased, suggesting that the FN receptor covered with sFN was exposed by trypsinization without destroying the receptor activity.	Iodine-125	33-37	fibronectin 1	Mus musculus	53-64
2539162-4	1989	In vivo treatment of KK mice with 1 mg/kg of CY 222 decreased the biosyntheses of type III collagen and of fibronectin to normal levels.	Cysteine	45-47	fibronectin 1	Mus musculus	107-118
2521609-3	1989	After trypsinization, binding of 125I-labeled plasma fibronectin (125I-pFN) to the macrophage monolayer was increased, suggesting that the FN receptor covered with sFN was exposed by trypsinization without destroying the receptor activity.	125i-pfn	66-74	fibronectin 1	Mus musculus	53-64
2971556-0	1988	12-O-tetradecanoylphorbol-13-acetate disrupts actin filaments and focal contacts and enhances binding of fibronectin-coated latex beads to 3T3-L1 cells.	Tetradecanoylphorbol Acetate	0-36	fibronectin 1	Mus musculus	105-116
2525358-2	1989	Initial studies described the significance of heparan sulfate proteoglycans of Balb/c 3T3 cells in their adhesion on fibronectin matrices, including their binding to multiple domains in FN, the importance of this binding in microfilament and close contact formation, and the cooperativity of both HS-PG and 140k glycoprotein integrin"s binding to FN to achieve tight-focal contacts under cells.	Heparitin Sulfate	46-61	fibronectin 1	Mus musculus	117-128
3242846-7	1988	The CPA of GNCP preparation was not blocked by the antiserum and scarcely inhibited in the presence of the synthetic cell attachment-promoting peptide Gly-Arg-Gly-Asp-Ser-Pro, a competitive inhibitor of fibronectin.	cpa	4-7	fibronectin 1	Mus musculus	203-214
3242846-7	1988	The CPA of GNCP preparation was not blocked by the antiserum and scarcely inhibited in the presence of the synthetic cell attachment-promoting peptide Gly-Arg-Gly-Asp-Ser-Pro, a competitive inhibitor of fibronectin.	gncp	11-15	fibronectin 1	Mus musculus	203-214
3242846-7	1988	The CPA of GNCP preparation was not blocked by the antiserum and scarcely inhibited in the presence of the synthetic cell attachment-promoting peptide Gly-Arg-Gly-Asp-Ser-Pro, a competitive inhibitor of fibronectin.	Glycine	151-154	fibronectin 1	Mus musculus	203-214
3242846-7	1988	The CPA of GNCP preparation was not blocked by the antiserum and scarcely inhibited in the presence of the synthetic cell attachment-promoting peptide Gly-Arg-Gly-Asp-Ser-Pro, a competitive inhibitor of fibronectin.	Arginine	155-158	fibronectin 1	Mus musculus	203-214
3242846-7	1988	The CPA of GNCP preparation was not blocked by the antiserum and scarcely inhibited in the presence of the synthetic cell attachment-promoting peptide Gly-Arg-Gly-Asp-Ser-Pro, a competitive inhibitor of fibronectin.	Glycine	159-162	fibronectin 1	Mus musculus	203-214
3242846-7	1988	The CPA of GNCP preparation was not blocked by the antiserum and scarcely inhibited in the presence of the synthetic cell attachment-promoting peptide Gly-Arg-Gly-Asp-Ser-Pro, a competitive inhibitor of fibronectin.	Aspartic Acid	163-166	fibronectin 1	Mus musculus	203-214
3242846-7	1988	The CPA of GNCP preparation was not blocked by the antiserum and scarcely inhibited in the presence of the synthetic cell attachment-promoting peptide Gly-Arg-Gly-Asp-Ser-Pro, a competitive inhibitor of fibronectin.	Serine	167-170	fibronectin 1	Mus musculus	203-214
3242846-7	1988	The CPA of GNCP preparation was not blocked by the antiserum and scarcely inhibited in the presence of the synthetic cell attachment-promoting peptide Gly-Arg-Gly-Asp-Ser-Pro, a competitive inhibitor of fibronectin.	Proline	171-174	fibronectin 1	Mus musculus	203-214
3191954-9	1988	Ecto-protein kinase phosphorylated fibronectin at serine and threonine residues which were distinct from the sites of intracellular fibronectin phosphorylation.	Serine	50-56	fibronectin 1	Mus musculus	35-46
3191954-9	1988	Ecto-protein kinase phosphorylated fibronectin at serine and threonine residues which were distinct from the sites of intracellular fibronectin phosphorylation.	Threonine	61-70	fibronectin 1	Mus musculus	35-46
3182933-6	1988	Control experiments indicated (a) that the tyrosine to phenylalanine change itself did not affect YP2 transport, (b) that the retardation of YP2 transport by chlorate occurred only with sulfatable but not with unsulfatable YP2, (c) that the transport difference between wild-type and mutant YP2 was not due to the level of YP2 expression, and (d) that transport of the endogenous secretory protein fibronectin was the same in L cell clones expressing wild-type and mutant YP2.	Chlorates	158-166	fibronectin 1	Mus musculus	398-409
2971556-1	1988	The effect of a tumor-promoting phorbol ester on the binding of fibronectin-coated beads to 3T3-L1 cells was studied to clarify the relationship between the binding of fibronectin to the cells, cell adhesion, and the organization of actin filaments.	Phorbol Esters	32-45	fibronectin 1	Mus musculus	64-75
2971556-1	1988	The effect of a tumor-promoting phorbol ester on the binding of fibronectin-coated beads to 3T3-L1 cells was studied to clarify the relationship between the binding of fibronectin to the cells, cell adhesion, and the organization of actin filaments.	Phorbol Esters	32-45	fibronectin 1	Mus musculus	168-179
2971556-11	1988	These results suggest that TPA specifically enhances the binding of fibronectin-coated beads to 3T3-L1 cells, and that TPA-induced binding of the beads may be related to disruption of focal contacts and reorganization of actin filaments.	Tetradecanoylphorbol Acetate	27-30	fibronectin 1	Mus musculus	68-79
3409215-5	1988	Enzymatic removal of sialic acid, polylactosamine, or complete asparagine-linked chains from purified P2B enhanced its binding to collagen, laminin, and fibronectin.	N-Acetylneuraminic Acid	21-32	fibronectin 1	Mus musculus	153-164
3220844-0	1988	Correlations between mouse 3T3 cell spreading and serum fibronectin adsorption on glass and hydroxyethylmethacrylate-ethylmethacrylate copolymers.	hydroxyethyl methacrylate-ethyl methacrylate	92-145	fibronectin 1	Mus musculus	56-67
3220844-7	1988	Large changes in cell spreading and fibronectin adsorption were observed when either serum concentration or polymer type was varied.	Polymers	108-115	fibronectin 1	Mus musculus	36-47
2465073-5	1988	A reduced level of pericellular fibronectin was also demonstrated in an in situ compressive urethane-induced mouse lung adenoma.	Urethane	92-100	fibronectin 1	Mus musculus	32-43
3409215-5	1988	Enzymatic removal of sialic acid, polylactosamine, or complete asparagine-linked chains from purified P2B enhanced its binding to collagen, laminin, and fibronectin.	Asparagine	63-73	fibronectin 1	Mus musculus	153-164
3403070-4	1988	This marked decrease in the extent and complexity of the cellular FN network, as a consequence of DMSO exposure, was reflected in a 90% decline in the amount of FN secreted into the culture medium.	Dimethyl Sulfoxide	98-102	fibronectin 1	Mus musculus	66-68
3403070-4	1988	This marked decrease in the extent and complexity of the cellular FN network, as a consequence of DMSO exposure, was reflected in a 90% decline in the amount of FN secreted into the culture medium.	Dimethyl Sulfoxide	98-102	fibronectin 1	Mus musculus	161-163
3403070-6	1988	In the HT cell system, DMSO appears to act in a bifunctional manner, increasing the production of certain tissue-specific proteins (e.g., albumin and alpha-fetoprotein) while decreasing the secretion and deposition of other cellular components (FN).	Dimethyl Sulfoxide	23-27	fibronectin 1	Mus musculus	245-247
3166462-2	1988	When attached to fibronectin-coated dishes MEL cells induce, upon addition of DMSO, a 7-d differentiation process during which they enucleate and reach the reticulocyte stage (Patel, V. P., and H. F. Lodish.	Dimethyl Sulfoxide	78-82	fibronectin 1	Mus musculus	17-28
2457084-2	1988	Within 4 weeks after bleomycin treatment, the pulmonary content of mRNAs encoding fibronectin, alpha 2I procollagen and alpha 1III procollagen was increased.	Bleomycin	21-30	fibronectin 1	Mus musculus	82-93
3190806-1	1988	The production of plasma fibronectin (PFN) in mice treated subcutaneously with N2-[(N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys(L18), muroctasin), was examined.	n2-[(n-acetylmuramoyl)-l-alanyl-d-isoglutaminyl]-n6-stearoyl-l-lysine	79-148	fibronectin 1	Mus musculus	25-36
2971556-11	1988	These results suggest that TPA specifically enhances the binding of fibronectin-coated beads to 3T3-L1 cells, and that TPA-induced binding of the beads may be related to disruption of focal contacts and reorganization of actin filaments.	Tetradecanoylphorbol Acetate	119-122	fibronectin 1	Mus musculus	68-79
3343338-1	1988	The experimental metastasis of B16-F10 murine melanoma cells is blocked by the anti-cell adhesive pentapeptide Gly-Arg-Gly-Asp-Ser (GRGDS) derived from the central cell-binding domain of fibronectin.	Glycine	111-114	fibronectin 1	Mus musculus	187-198
2834405-5	1988	Addition to the culture medium of a synthetic peptide containing the Arg-Gly-Asp tripeptide cell recognition sequence of fibronectin inhibits trophoblast outgrowth on both laminin and fibronectin.	Peptides	46-53	fibronectin 1	Mus musculus	121-132
2834405-5	1988	Addition to the culture medium of a synthetic peptide containing the Arg-Gly-Asp tripeptide cell recognition sequence of fibronectin inhibits trophoblast outgrowth on both laminin and fibronectin.	Peptides	46-53	fibronectin 1	Mus musculus	184-195
2834405-5	1988	Addition to the culture medium of a synthetic peptide containing the Arg-Gly-Asp tripeptide cell recognition sequence of fibronectin inhibits trophoblast outgrowth on both laminin and fibronectin.	arginyl-glycyl-aspartic acid	69-80	fibronectin 1	Mus musculus	121-132
2834405-5	1988	Addition to the culture medium of a synthetic peptide containing the Arg-Gly-Asp tripeptide cell recognition sequence of fibronectin inhibits trophoblast outgrowth on both laminin and fibronectin.	arginyl-glycyl-aspartic acid	69-80	fibronectin 1	Mus musculus	184-195
2834405-5	1988	Addition to the culture medium of a synthetic peptide containing the Arg-Gly-Asp tripeptide cell recognition sequence of fibronectin inhibits trophoblast outgrowth on both laminin and fibronectin.	tripeptide K-26	81-91	fibronectin 1	Mus musculus	121-132
2834405-5	1988	Addition to the culture medium of a synthetic peptide containing the Arg-Gly-Asp tripeptide cell recognition sequence of fibronectin inhibits trophoblast outgrowth on both laminin and fibronectin.	tripeptide K-26	81-91	fibronectin 1	Mus musculus	184-195
3343338-1	1988	The experimental metastasis of B16-F10 murine melanoma cells is blocked by the anti-cell adhesive pentapeptide Gly-Arg-Gly-Asp-Ser (GRGDS) derived from the central cell-binding domain of fibronectin.	Arginine	115-118	fibronectin 1	Mus musculus	187-198
3343338-1	1988	The experimental metastasis of B16-F10 murine melanoma cells is blocked by the anti-cell adhesive pentapeptide Gly-Arg-Gly-Asp-Ser (GRGDS) derived from the central cell-binding domain of fibronectin.	Glycine	119-122	fibronectin 1	Mus musculus	187-198
3343338-1	1988	The experimental metastasis of B16-F10 murine melanoma cells is blocked by the anti-cell adhesive pentapeptide Gly-Arg-Gly-Asp-Ser (GRGDS) derived from the central cell-binding domain of fibronectin.	Aspartic Acid	123-126	fibronectin 1	Mus musculus	187-198
3343338-1	1988	The experimental metastasis of B16-F10 murine melanoma cells is blocked by the anti-cell adhesive pentapeptide Gly-Arg-Gly-Asp-Ser (GRGDS) derived from the central cell-binding domain of fibronectin.	Serine	127-130	fibronectin 1	Mus musculus	187-198
2961705-6	1988	Analysis of 35S-methionine-labelled cell aggregates cultured on collagen gels also revealed a decrease in the 140-kDa region and a greater labelling of multiple 54-kDa components, compared to the same cells flattened on fibronectin.	Methionine	16-26	fibronectin 1	Mus musculus	220-231
3421811-8	1988	Poly(A)+-enriched RNA from NCE cells grown on fibronectin and in standard culture medium, did not, whereas the RNA from NCE cells grown on the extracellular matrix and in the colon carcinoma conditioned medium hybridized with 32P-cDNA from colon carcinoma.	Poly A	0-8	fibronectin 1	Mus musculus	46-57
2963012-4	1988	Cells harvested with either trypsin or EDTA bound to fibronectin; binding of trypsin-released cells was inhibited by the peptide GRGDS but not by heparin, whereas binding of EDTA-released cells was inhibited only by a combination of GRDS and heparin, suggesting two distinct cell binding mechanisms.	Edetic Acid	39-43	fibronectin 1	Mus musculus	53-64
2963012-5	1988	In the presence of GRGDS, the EDTA-released cells bound to fibronectin via the cell surface PG.	Edetic Acid	30-34	fibronectin 1	Mus musculus	59-70
2963012-6	1988	Binding via the cell surface PG was to the COOH-terminal heparin binding domain of fibronectin.	Heparin	57-64	fibronectin 1	Mus musculus	83-94
2963012-9	1988	These results indicate that the mammary epithelial cells have at least two distinct cell surface receptors for fibronectin: a trypsin-resistant molecule that binds cells to the sequence RGD and a trypsin-labile, heparan sulfate-rich PG that binds cells to the COOH-terminal heparin binding domain.	Heparitin Sulfate	212-227	fibronectin 1	Mus musculus	111-122
2963012-9	1988	These results indicate that the mammary epithelial cells have at least two distinct cell surface receptors for fibronectin: a trypsin-resistant molecule that binds cells to the sequence RGD and a trypsin-labile, heparan sulfate-rich PG that binds cells to the COOH-terminal heparin binding domain.	Heparin	274-281	fibronectin 1	Mus musculus	111-122
3334715-5	1988	In another series of experiments the effect of laminin and fibronectin on thymidine uptake and proliferation of myoblasts was tested.	Thymidine	74-83	fibronectin 1	Mus musculus	59-70
3255048-9	1988	In contrast to the inhibition of the synthesis of mitogen induced proteins, actinomycin D super-induced the intracellular and extracellular levels of the matrix proteins fibronectin and procollagens.	Dactinomycin	76-89	fibronectin 1	Mus musculus	170-181
3691670-2	1987	Both retinoic acid-treated and control cells attached efficiently to fibronectin or gelatin substrates without any significant difference.	Tretinoin	5-18	fibronectin 1	Mus musculus	69-80
2961771-4	1987	In contrast, cells induced by DMSO on fibronectin-coated dishes for 7 d differentiate into enucleating cells, reticulocytes, and erythrocytes.	Dimethyl Sulfoxide	30-34	fibronectin 1	Mus musculus	38-49
3320063-6	1987	The induction of differentiation in the AKR-MCA cells by N,N-dimethylformamide (DMF) restored fibronectin to the surface of the AKR-MCA cells but reduced laminin expression only slightly.	Dimethylformamide	57-78	fibronectin 1	Mus musculus	94-105
3320063-6	1987	The induction of differentiation in the AKR-MCA cells by N,N-dimethylformamide (DMF) restored fibronectin to the surface of the AKR-MCA cells but reduced laminin expression only slightly.	Dimethylformamide	80-83	fibronectin 1	Mus musculus	94-105
2824089-1	1987	The adhesion of Balb/c 3T12 cells to fibronectin (FN) and to denatured (DC) or native (NC) collagen is differentially sensitive to divalent cations and to sodium azide.	Sodium Azide	155-167	fibronectin 1	Mus musculus	37-48
2824089-1	1987	The adhesion of Balb/c 3T12 cells to fibronectin (FN) and to denatured (DC) or native (NC) collagen is differentially sensitive to divalent cations and to sodium azide.	Sodium Azide	155-167	fibronectin 1	Mus musculus	50-52
2824089-2	1987	Short-time adhesion (10 min) to FN requires either Mg2+ or Mn2+, whereas only Mn2+ stimulates attachment to DC and NC.	magnesium ion	51-55	fibronectin 1	Mus musculus	32-34
2824089-2	1987	Short-time adhesion (10 min) to FN requires either Mg2+ or Mn2+, whereas only Mn2+ stimulates attachment to DC and NC.	Manganese(2+)	59-63	fibronectin 1	Mus musculus	32-34
2824089-3	1987	Azide treatment only slightly affects adhesion of cells to FN, but strongly inhibits cell attachment to DC and NC.	Azides	0-5	fibronectin 1	Mus musculus	59-61
2958379-3	1987	First, in the presence of soluble heparin, the rate at which embryos attach and outgrow on laminin, fibronectin, or monolayers of uterine epithelial cells is reduced considerably.	Heparin	34-41	fibronectin 1	Mus musculus	100-111
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Heparin	73-80	fibronectin 1	Mus musculus	15-26
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Heparin	73-80	fibronectin 1	Mus musculus	178-189
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Arginine	119-122	fibronectin 1	Mus musculus	15-26
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Arginine	119-122	fibronectin 1	Mus musculus	178-189
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Glycine	123-126	fibronectin 1	Mus musculus	15-26
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Glycine	123-126	fibronectin 1	Mus musculus	178-189
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Aspartic Acid	127-130	fibronectin 1	Mus musculus	15-26
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Aspartic Acid	127-130	fibronectin 1	Mus musculus	178-189
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Serine	131-134	fibronectin 1	Mus musculus	15-26
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Serine	131-134	fibronectin 1	Mus musculus	178-189
2958485-8	1987	All evidence indicated that the mechanism using the intact pFN molecule involved the binding of the DS-PGs to the glycosaminoglycan (GAG)-binding sites of substratum-bound pFN, thereby inhibiting the interaction of the fibronectin with receptors on the cell surface.	(R)-Fenoprofen	59-62	fibronectin 1	Mus musculus	219-230
2958485-8	1987	All evidence indicated that the mechanism using the intact pFN molecule involved the binding of the DS-PGs to the glycosaminoglycan (GAG)-binding sites of substratum-bound pFN, thereby inhibiting the interaction of the fibronectin with receptors on the cell surface.	Deuterium	100-102	fibronectin 1	Mus musculus	219-230
2958485-8	1987	All evidence indicated that the mechanism using the intact pFN molecule involved the binding of the DS-PGs to the glycosaminoglycan (GAG)-binding sites of substratum-bound pFN, thereby inhibiting the interaction of the fibronectin with receptors on the cell surface.	Glycosaminoglycans	114-131	fibronectin 1	Mus musculus	219-230
2958485-8	1987	All evidence indicated that the mechanism using the intact pFN molecule involved the binding of the DS-PGs to the glycosaminoglycan (GAG)-binding sites of substratum-bound pFN, thereby inhibiting the interaction of the fibronectin with receptors on the cell surface.	Glycosaminoglycans	133-136	fibronectin 1	Mus musculus	219-230
3629514-3	1987	The TCDD-treated and control kidneys showed the same pattern of staining for fibronectin, but TCDD-treated kidneys displayed a diminished overall intensity.	Polychlorinated Dibenzodioxins	4-8	fibronectin 1	Mus musculus	77-88
2956270-2	1987	Whereas the Ba F3 cell line, which has both immunoglobulin heavy- and light-chain genes in germline configuration, interacts with the arg-gly-asp-containing cell-binding domain of fibronectin, the B-committed line PD 31, which is undergoing rearrangement of immunoglobulin light-chain genes, does not.	Arginine	134-137	fibronectin 1	Mus musculus	180-191
2956270-2	1987	Whereas the Ba F3 cell line, which has both immunoglobulin heavy- and light-chain genes in germline configuration, interacts with the arg-gly-asp-containing cell-binding domain of fibronectin, the B-committed line PD 31, which is undergoing rearrangement of immunoglobulin light-chain genes, does not.	Glycine	138-141	fibronectin 1	Mus musculus	180-191
2956270-2	1987	Whereas the Ba F3 cell line, which has both immunoglobulin heavy- and light-chain genes in germline configuration, interacts with the arg-gly-asp-containing cell-binding domain of fibronectin, the B-committed line PD 31, which is undergoing rearrangement of immunoglobulin light-chain genes, does not.	Aspartic Acid	142-145	fibronectin 1	Mus musculus	180-191
2956270-4	1987	PD 31 cells recognize a different domain of the fibronectin molecule, which is contained within the carboxy terminal segment possessing a high-affinity binding site for heparin.	Heparin	169-176	fibronectin 1	Mus musculus	48-59
3470766-6	1987	However, the relative rate of incorporation of the tracer in the NaDodSO4-extractable, pericellular polymeric form was increased in the diabetic KK fibroblasts both for total proteins and for fibronectin.	nadodso4	65-73	fibronectin 1	Mus musculus	192-203
3470766-8	1987	The rate of passage of fibronectin from the deoxycholate-soluble (cellular compartment) form to the NaDodSO4-soluble (pericellular polymeric) form was strongly accelerated in the diabetic fibroblast cultures.	Deoxycholic Acid	44-56	fibronectin 1	Mus musculus	23-34
3470766-8	1987	The rate of passage of fibronectin from the deoxycholate-soluble (cellular compartment) form to the NaDodSO4-soluble (pericellular polymeric) form was strongly accelerated in the diabetic fibroblast cultures.	nadodso4	100-108	fibronectin 1	Mus musculus	23-34
3470766-10	1987	The increase of fibronectin in diabetic connective tissues, in the matrix as well as in the basement membranes, may play a role in the mechanism of micro- and macroangiopathies and in the perturbed permeability characteristics of the diabetic capillaries, and as a glycoprotein it may contribute to the increased periodic acid/Schiff reagent staining of diabetic capillary basement membranes.	Periodic Acid	313-326	fibronectin 1	Mus musculus	16-27
3470766-10	1987	The increase of fibronectin in diabetic connective tissues, in the matrix as well as in the basement membranes, may play a role in the mechanism of micro- and macroangiopathies and in the perturbed permeability characteristics of the diabetic capillaries, and as a glycoprotein it may contribute to the increased periodic acid/Schiff reagent staining of diabetic capillary basement membranes.	schiff	327-333	fibronectin 1	Mus musculus	16-27
2956468-5	1987	The glycosaminoglycan containing ectodomain of this PG binds with high affinity Type I, III and V collagen fibrils and the C-terminal heparin binding domain of fibronectin.	pg	52-54	fibronectin 1	Mus musculus	160-171
3027700-3	1987	The recombinant fibronectins (deminectins) are processed and secreted by the cells and form disulfide-bonded dimers with themselves and with endogenous fibronectin subunits.	Disulfides	92-101	fibronectin 1	Mus musculus	16-27
2950119-0	1987	The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading.	Arginine	41-44	fibronectin 1	Mus musculus	4-15
2950119-0	1987	The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading.	Glycine	45-48	fibronectin 1	Mus musculus	4-15
2950119-0	1987	The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading.	Aspartic Acid	49-52	fibronectin 1	Mus musculus	4-15
2950119-0	1987	The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading.	Serine	53-56	fibronectin 1	Mus musculus	4-15
3540005-4	1987	Double-labelling experiments on primary cultures of optic nerve using antibodies to glial fibrillary acidic protein, galactocerebroside and fibronectin showed that GTE52 labelled a sub-population of astrocyte glia, possibly corresponding to the type 2 astrocytes, oligodendrocytes and not fibroblasts.	gte52	164-169	fibronectin 1	Mus musculus	140-151
2956468-5	1987	The glycosaminoglycan containing ectodomain of this PG binds with high affinity Type I, III and V collagen fibrils and the C-terminal heparin binding domain of fibronectin.	Heparin	134-141	fibronectin 1	Mus musculus	160-171
4010229-4	1985	Selective and partial inhibition of cell attachment to type I collagen, and, to a lesser extent, fibronectin, occurred upon preincubating these substrates with the sulfated glycosaminoglycans, heparin and heparan sulfate, at concentrations of 1 to 100 micrograms/ml; for 3T3 cells heparin was significantly more inhibitory (mean maximal inhibition of approximately 40%) than were two heparan sulfate fractions.	Glycosaminoglycans	173-191	fibronectin 1	Mus musculus	97-108
3093072-3	1986	Prolonged incubation with TPA allowed P- cells to regain their original appearance and resulted in growth inhibition; however, the extended presence of TPA produced in P+ cells persistent alterations in the distribution of actin, vinculin, and fibronectin.	Tetradecanoylphorbol Acetate	152-155	fibronectin 1	Mus musculus	244-255
3093061-8	1986	Tunicamycin-treated B16-F10 cells exhibited poor adhesion to substrate-adsorbed fibronectin and laminin, whereas both castanospermine- and swainsonine-treated cells possessed near normal adhesive capacity; furthermore, the initial rate of loss of tunicamycin-treated cells from the lungs of mice was substantially greater than either control, castanospermine- or swainsonine-treated cells.	Tunicamycin	0-11	fibronectin 1	Mus musculus	80-91
2428041-4	1986	In this study we report that the outgrowth of blastocysts on fibronectin-coated dishes is inhibited in a dose-dependent manner by the presence of a hexapeptide containing the sequence Arg-Gly-Asp, which has been shown previously to be recognized by the fibronectin receptor.	Arginine	184-187	fibronectin 1	Mus musculus	61-72
2428041-4	1986	In this study we report that the outgrowth of blastocysts on fibronectin-coated dishes is inhibited in a dose-dependent manner by the presence of a hexapeptide containing the sequence Arg-Gly-Asp, which has been shown previously to be recognized by the fibronectin receptor.	Arginine	184-187	fibronectin 1	Mus musculus	253-264
2428041-4	1986	In this study we report that the outgrowth of blastocysts on fibronectin-coated dishes is inhibited in a dose-dependent manner by the presence of a hexapeptide containing the sequence Arg-Gly-Asp, which has been shown previously to be recognized by the fibronectin receptor.	Glycine	188-191	fibronectin 1	Mus musculus	61-72
2428041-4	1986	In this study we report that the outgrowth of blastocysts on fibronectin-coated dishes is inhibited in a dose-dependent manner by the presence of a hexapeptide containing the sequence Arg-Gly-Asp, which has been shown previously to be recognized by the fibronectin receptor.	Glycine	188-191	fibronectin 1	Mus musculus	253-264
2428041-4	1986	In this study we report that the outgrowth of blastocysts on fibronectin-coated dishes is inhibited in a dose-dependent manner by the presence of a hexapeptide containing the sequence Arg-Gly-Asp, which has been shown previously to be recognized by the fibronectin receptor.	Aspartic Acid	192-195	fibronectin 1	Mus musculus	61-72
2428041-4	1986	In this study we report that the outgrowth of blastocysts on fibronectin-coated dishes is inhibited in a dose-dependent manner by the presence of a hexapeptide containing the sequence Arg-Gly-Asp, which has been shown previously to be recognized by the fibronectin receptor.	Aspartic Acid	192-195	fibronectin 1	Mus musculus	253-264
2428041-9	1986	These findings suggest that differentiation of cells of the trophectoderm into trophoblast cells with an invasive phenotype may involve the production of cell surface receptors for fibronectin and possibly for other proteins that contain the Arg-Gly-Asp recognition sequence.	Glycine	246-249	fibronectin 1	Mus musculus	181-192
2428041-9	1986	These findings suggest that differentiation of cells of the trophectoderm into trophoblast cells with an invasive phenotype may involve the production of cell surface receptors for fibronectin and possibly for other proteins that contain the Arg-Gly-Asp recognition sequence.	Aspartic Acid	250-253	fibronectin 1	Mus musculus	181-192
3720853-0	1986	Substratum contacts and cytoskeletal reorganization of BALB/c 3T3 cells on a cell-binding fragment and heparin-binding fragments of plasma fibronectin.	Heparin	103-110	fibronectin 1	Mus musculus	139-150
2426286-4	1986	The expression of T antigen and fibronectin was sensitive to actinomycin D and cycloheximide.	Dactinomycin	61-74	fibronectin 1	Mus musculus	32-43
2426286-4	1986	The expression of T antigen and fibronectin was sensitive to actinomycin D and cycloheximide.	Cycloheximide	79-92	fibronectin 1	Mus musculus	32-43
2942550-8	1986	Finally, the tetrapeptide Arg-Gly-Asp-Ser, which corresponds to the fibronectin sequence recognized by fibroblastic cells, specifically and competitively inhibited attachment of hemopoietic cells to this molecule.	Arginine	26-29	fibronectin 1	Mus musculus	68-79
2942550-8	1986	Finally, the tetrapeptide Arg-Gly-Asp-Ser, which corresponds to the fibronectin sequence recognized by fibroblastic cells, specifically and competitively inhibited attachment of hemopoietic cells to this molecule.	Glycine	30-33	fibronectin 1	Mus musculus	68-79
2942550-8	1986	Finally, the tetrapeptide Arg-Gly-Asp-Ser, which corresponds to the fibronectin sequence recognized by fibroblastic cells, specifically and competitively inhibited attachment of hemopoietic cells to this molecule.	Aspartic Acid	34-37	fibronectin 1	Mus musculus	68-79
2942550-8	1986	Finally, the tetrapeptide Arg-Gly-Asp-Ser, which corresponds to the fibronectin sequence recognized by fibroblastic cells, specifically and competitively inhibited attachment of hemopoietic cells to this molecule.	Serine	38-41	fibronectin 1	Mus musculus	68-79
3726541-3	1986	Gly-Arg-Gly-Asp-Ser (GRGDS) is a pentapeptide sequence that appears to be critical for cell interaction with fibronectin.	glycyl-arginyl-glycyl-aspartyl-serine	0-19	fibronectin 1	Mus musculus	109-120
3700477-0	1986	Fibrillar organization of fibronectin is expressed coordinately with cell surface gangliosides in a variant murine fibroblast.	Gangliosides	82-94	fibronectin 1	Mus musculus	26-37
3700477-2	1986	When the cells are exposed to exogenous gangliosides, fibrillar strands of fibronectin become attached to the cell surface.	Gangliosides	40-52	fibronectin 1	Mus musculus	75-86
3700477-13	1986	Our results further establish that the ability of a cell to organize fibronectin into an extracellular matrix is dependent on certain gangliosides, but they also indicate that cell adhesion to fibronectin is independent of these gangliosides.	Gangliosides	134-146	fibronectin 1	Mus musculus	69-80
2935542-0	1986	Variants of BALB/c 3T3 cells lacking complex gangliosides retain a fibronectin matrix and spread normally on fibronectin-coated substrates.	Gangliosides	45-57	fibronectin 1	Mus musculus	67-78
2935542-1	1986	Evidence has accumulated that di- and trisialogangliosides are involved in the interaction of cells with fibronectin.	di- and trisialogangliosides	30-58	fibronectin 1	Mus musculus	105-116
2935542-2	1986	We have therefore tested the ability of variants of BALB/c 3T3 deficient in such gangliosides to organize a fibronectin matrix and to spread on fibronectin-coated substrates.	Gangliosides	81-93	fibronectin 1	Mus musculus	108-119
2949946-2	1986	Biochemical analyses of substratum adhesion sites indicated important functions for cell-surface heparan sulphate proteoglycan (HS-PG) in directly mediating adhesive responses by the binding of heparan sulphate sequences to fibronectin.	Heparitin Sulfate	97-113	fibronectin 1	Mus musculus	224-235
2868739-8	1985	The presence of both collagen and fibronectin was a necessary precondition for the spreading of cells in a manner sensitive to Gly-Pro-Ala.	Gly-Pro-Ala	127-138	fibronectin 1	Mus musculus	34-45
3298663-5	1987	It was shown that neuronal densities similar to those with uninhibited media may be retained in the presence of cytosine arabinoside if fibronectin-coated substrata are prepared.	Cytarabine	112-132	fibronectin 1	Mus musculus	136-147
3777134-2	1986	With the use of the Western immunoblotting technique, sera of mice immunized with native or sodium dodecyl sulfate (SDS)-treated fibronectin reacted with native, reduced and alkylated, and heat-and SDS-treated fibronectin.	Sodium Dodecyl Sulfate	92-114	fibronectin 1	Mus musculus	129-140
3777134-2	1986	With the use of the Western immunoblotting technique, sera of mice immunized with native or sodium dodecyl sulfate (SDS)-treated fibronectin reacted with native, reduced and alkylated, and heat-and SDS-treated fibronectin.	Sodium Dodecyl Sulfate	92-114	fibronectin 1	Mus musculus	210-221
3777134-2	1986	With the use of the Western immunoblotting technique, sera of mice immunized with native or sodium dodecyl sulfate (SDS)-treated fibronectin reacted with native, reduced and alkylated, and heat-and SDS-treated fibronectin.	Sodium Dodecyl Sulfate	116-119	fibronectin 1	Mus musculus	129-140
3777134-2	1986	With the use of the Western immunoblotting technique, sera of mice immunized with native or sodium dodecyl sulfate (SDS)-treated fibronectin reacted with native, reduced and alkylated, and heat-and SDS-treated fibronectin.	Sodium Dodecyl Sulfate	116-119	fibronectin 1	Mus musculus	210-221
3777134-2	1986	With the use of the Western immunoblotting technique, sera of mice immunized with native or sodium dodecyl sulfate (SDS)-treated fibronectin reacted with native, reduced and alkylated, and heat-and SDS-treated fibronectin.	Sodium Dodecyl Sulfate	198-201	fibronectin 1	Mus musculus	129-140
3777134-4	1986	In a competitive inhibition ELISA, the reactivity of immune sera from mice immunized with reduced and alkylated fibronectin to insolubilized reduced and alkylated fibronectin could be inhibited (66%) by preincubation with soluble reduced and alkylated fibronectin, but not by preincubation with native or SDS-treated fibronectin (less than 25%).	Sodium Dodecyl Sulfate	305-308	fibronectin 1	Mus musculus	112-123
3777134-4	1986	In a competitive inhibition ELISA, the reactivity of immune sera from mice immunized with reduced and alkylated fibronectin to insolubilized reduced and alkylated fibronectin could be inhibited (66%) by preincubation with soluble reduced and alkylated fibronectin, but not by preincubation with native or SDS-treated fibronectin (less than 25%).	Sodium Dodecyl Sulfate	305-308	fibronectin 1	Mus musculus	163-174
3777134-4	1986	In a competitive inhibition ELISA, the reactivity of immune sera from mice immunized with reduced and alkylated fibronectin to insolubilized reduced and alkylated fibronectin could be inhibited (66%) by preincubation with soluble reduced and alkylated fibronectin, but not by preincubation with native or SDS-treated fibronectin (less than 25%).	Sodium Dodecyl Sulfate	305-308	fibronectin 1	Mus musculus	163-174
3777134-4	1986	In a competitive inhibition ELISA, the reactivity of immune sera from mice immunized with reduced and alkylated fibronectin to insolubilized reduced and alkylated fibronectin could be inhibited (66%) by preincubation with soluble reduced and alkylated fibronectin, but not by preincubation with native or SDS-treated fibronectin (less than 25%).	Sodium Dodecyl Sulfate	305-308	fibronectin 1	Mus musculus	163-174
3528285-2	1986	Methanol-5% glacial acetic acid in dry ice-fixed cell monolayers showed mainly intracellular FN staining.	Methanol	0-8	fibronectin 1	Mus musculus	93-95
3528285-2	1986	Methanol-5% glacial acetic acid in dry ice-fixed cell monolayers showed mainly intracellular FN staining.	Acetic Acid	20-31	fibronectin 1	Mus musculus	93-95
3741402-9	1986	Affinity chromatography of these proteoglycans on columns of either immobilized platelet factor 4 or immobilized plasma fibronectin revealed that most of the chondroitin sulphate proteoglycan and the heparan sulphate proteoglycan bound to platelet factor 4 but that only the heparan sulphate proteoglycan bound to fibronectin, providing a ready means of separating the two proteoglycan classes.	Chondroitin Sulfates	158-178	fibronectin 1	Mus musculus	120-131
3949886-3	1986	Proteolysis experiments confirmed that this cell line has calcium-protected polypeptides necessary for cell spreading on fibronectin.	Calcium	58-65	fibronectin 1	Mus musculus	121-132
3943552-8	1986	These results support the hypothesis that the mechanism of PMC migration involves fibronectin, collagen and sulfated proteoglycans which contain dermatan sulfate.	Dermatan Sulfate	145-161	fibronectin 1	Mus musculus	82-93
3816422-11	1986	In the presence of DS-PGs, the adhesion of the fibroblasts to fibronectin was essentially abolished.	Deuterium	19-21	fibronectin 1	Mus musculus	62-73
4026839-2	1985	Specifically, collagen types I, III, IV, laminin and fibronectin were identified by SDS-PAGE.	Sodium Dodecyl Sulfate	84-87	fibronectin 1	Mus musculus	53-64
4010229-4	1985	Selective and partial inhibition of cell attachment to type I collagen, and, to a lesser extent, fibronectin, occurred upon preincubating these substrates with the sulfated glycosaminoglycans, heparin and heparan sulfate, at concentrations of 1 to 100 micrograms/ml; for 3T3 cells heparin was significantly more inhibitory (mean maximal inhibition of approximately 40%) than were two heparan sulfate fractions.	Heparin	193-200	fibronectin 1	Mus musculus	97-108
4010229-4	1985	Selective and partial inhibition of cell attachment to type I collagen, and, to a lesser extent, fibronectin, occurred upon preincubating these substrates with the sulfated glycosaminoglycans, heparin and heparan sulfate, at concentrations of 1 to 100 micrograms/ml; for 3T3 cells heparin was significantly more inhibitory (mean maximal inhibition of approximately 40%) than were two heparan sulfate fractions.	Heparitin Sulfate	205-220	fibronectin 1	Mus musculus	97-108
3858579-3	1985	This lesion in carbohydrate structure has been shown to contribute to the more adhesive behavior of MDW4 cells on laminin, fibronectin, and type IV collagen and to the increased sensitivity of MDW4 to natural killer (NK) cell lysis in vitro.	Carbohydrates	15-27	fibronectin 1	Mus musculus	123-134
6143587-5	1984	In cultures treated with dibutyryl-cAMP no other cell type was found positive for fibronectin.	Bucladesine	25-39	fibronectin 1	Mus musculus	82-93
3882721-0	1985	Fluorescent gangliosides as probes for the retention and organization of fibronectin by ganglioside-deficient mouse cells.	Gangliosides	12-23	fibronectin 1	Mus musculus	73-84
3882721-1	1985	Ganglioside-deficient transformed mouse fibroblasts (NCTC 2071A cells), which grow in serum-free medium, synthesize fibronectin but do not retain it on the cell surface.	Gangliosides	0-11	fibronectin 1	Mus musculus	116-127
3882721-3	1985	When the cells were stained with anti-fibronectin antibodies and a fluorescent second antibody, fibrillar strands of fibronectin were observed to be attached to the cell surface, with partial coincidence of the patterns of direct ganglioside fluorescence and indirect fibronectin immunofluorescence at the cell surface.	Gangliosides	230-241	fibronectin 1	Mus musculus	117-128
3882721-3	1985	When the cells were stained with anti-fibronectin antibodies and a fluorescent second antibody, fibrillar strands of fibronectin were observed to be attached to the cell surface, with partial coincidence of the patterns of direct ganglioside fluorescence and indirect fibronectin immunofluorescence at the cell surface.	Gangliosides	230-241	fibronectin 1	Mus musculus	117-128
3882721-7	1985	When exogenous gangliosides were included in the incubation, there was a striking increase in cell-associated exogenous fibronectin, which was highly organized into a fibrillar network.	Gangliosides	15-27	fibronectin 1	Mus musculus	120-131
3882721-8	1985	Conversely, cells incubated for 18 h with exogenous unmodified gangliosides exhibited a highly organized network of endogenously derived fibronectin.	Gangliosides	63-75	fibronectin 1	Mus musculus	137-148
3882721-9	1985	Upon further incubation of the cells for 2 h with fluorescent gangliosides, there was considerable co-distribution of the fluorescent gangliosides with the fibronectin network as revealed by immunofluorescence.	Gangliosides	62-74	fibronectin 1	Mus musculus	156-167
3882721-9	1985	Upon further incubation of the cells for 2 h with fluorescent gangliosides, there was considerable co-distribution of the fluorescent gangliosides with the fibronectin network as revealed by immunofluorescence.	Gangliosides	134-146	fibronectin 1	Mus musculus	156-167
3882721-10	1985	Our results support the concept that gangliosides can mediate the attachment of fibronectin to the cell surface and its organization into a fibrillar network.	Gangliosides	37-49	fibronectin 1	Mus musculus	80-91
3967339-2	1985	The addition of 10(-8) M 12-O-tetradecanoylphorbol-13-acetate (TPA) to promotable clones caused a 2-fold enhancement of the FN release over solvent control.	Tetradecanoylphorbol Acetate	25-61	fibronectin 1	Mus musculus	124-126
3967339-2	1985	The addition of 10(-8) M 12-O-tetradecanoylphorbol-13-acetate (TPA) to promotable clones caused a 2-fold enhancement of the FN release over solvent control.	Tetradecanoylphorbol Acetate	63-66	fibronectin 1	Mus musculus	124-126
3967339-4	1985	Mezerein, a non-phorbol diterpene and second-stage tumor promoter was also found to be active in causing enhanced FN release in promotable but not in non-promotable clones.	mezerein	0-8	fibronectin 1	Mus musculus	114-116
3967339-5	1985	The vitamin A derivative retinoic acid (RA) antagonized the TPA-caused FN-release in promotable clones.	Vitamin A	4-13	fibronectin 1	Mus musculus	71-73
3967339-5	1985	The vitamin A derivative retinoic acid (RA) antagonized the TPA-caused FN-release in promotable clones.	Tretinoin	25-38	fibronectin 1	Mus musculus	71-73
3967339-5	1985	The vitamin A derivative retinoic acid (RA) antagonized the TPA-caused FN-release in promotable clones.	Tretinoin	40-42	fibronectin 1	Mus musculus	71-73
3967339-5	1985	The vitamin A derivative retinoic acid (RA) antagonized the TPA-caused FN-release in promotable clones.	Tetradecanoylphorbol Acetate	60-63	fibronectin 1	Mus musculus	71-73
6379853-2	1984	Native agarose beads preincubated with 125I-fibronectin were neither associated with nor taken up by mouse macrophages after 30 min of incubation under serum-free conditions.	Sepharose	7-14	fibronectin 1	Mus musculus	44-55
6204647-0	1984	Hyaluronate binding proteins also bind to fibronectin, laminin and collagen.	hyaluronate	0-11	fibronectin 1	Mus musculus	42-53
6585955-2	1984	Dimethyl sulfoxide-induced differentiation of these cells caused a dramatic decrease in adhesion to fibronectin that was correlated with synthesis of the erythrocyte glycoprotein "band III," a membrane marker of the differentiated erythrocyte.	Dimethyl Sulfoxide	0-18	fibronectin 1	Mus musculus	100-111
3876600-0	1985	Fibronectin binds to complement-coated agarose beads and increases their association to mouse macrophages.	Sepharose	39-46	fibronectin 1	Mus musculus	0-11
3876600-1	1985	We have studied the binding of fibronectin to complement (C3b, C3bi, C3d)-coated agarose beads and its effect on cell association of such beads to mouse macrophages.	Sepharose	81-88	fibronectin 1	Mus musculus	31-42
3876600-2	1985	Fibronectin bound to agarose beads preincubated in human serum, whereas no binding occurred after preincubation of the beads with complement-inactivated (50 degrees C for 20 min or ethylenediaminetetraacetic acid) sera.	Sepharose	21-28	fibronectin 1	Mus musculus	0-11
3876600-3	1985	The binding of iodine-labelled fibronectin to beads preincubated in fibronectin-depleted serum (HS-FIB) was about twice that of beads preincubated in normal serum.	Iodine	15-21	fibronectin 1	Mus musculus	31-42
3876600-3	1985	The binding of iodine-labelled fibronectin to beads preincubated in fibronectin-depleted serum (HS-FIB) was about twice that of beads preincubated in normal serum.	Iodine	15-21	fibronectin 1	Mus musculus	68-79
3876600-5	1985	A similar amount of fibronectin bound to agarose beads coated with equimolar amounts of C3b, C3bi, or C3d, suggesting that the common domain C3d carries the main binding site(s) for fibronectin.	Sepharose	41-48	fibronectin 1	Mus musculus	20-31
3876600-6	1985	Preincubation of serum-treated and trypsinized agarose beads with fibronectin led to an increased association (22%) of such beads to mouse macrophages.	Sepharose	47-54	fibronectin 1	Mus musculus	66-77
3876600-7	1985	The results indicate that fibronectin promotes binding of complement-coated agarose beads to mouse macrophages, whereas the ingestion of the beads is mediated via complement C3 receptors.	Sepharose	76-83	fibronectin 1	Mus musculus	26-37
3882721-0	1985	Fluorescent gangliosides as probes for the retention and organization of fibronectin by ganglioside-deficient mouse cells.	Gangliosides	12-24	fibronectin 1	Mus musculus	73-84
2421956-5	1985	We now report that plasma fibronectin is a significant acute phase reactant in mice with levels increasing from a baseline mean value of 257 ug/ml to 595 ug/ml by 24 hours (p less than 0.01) after a subcutaneous injection of silver nitrate.	Silver Nitrate	225-239	fibronectin 1	Mus musculus	26-37
6480690-0	1984	Lipoprotein-heparin-fibronectin-denatured collagen complexes enhance cholesteryl ester accumulation in macrophages.	Cholesterol Esters	69-86	fibronectin 1	Mus musculus	20-31
6480690-4	1984	The results of these experiments have demonstrated that the cholesteryl ester content of macrophages incubated with a particular suspension of LDL, heparin, fibronectin, and collagen complexes is four- to fivefold that of cells incubated with LDL alone.	Cholesterol Esters	60-77	fibronectin 1	Mus musculus	157-168
6205085-0	1984	Granule-associated serine neutral proteases of the mouse bone marrow-derived mast cell that degrade fibronectin: their increase after sodium butyrate treatment of the cells.	Butyric Acid	134-149	fibronectin 1	Mus musculus	100-111
6205085-11	1984	As assessed by optical density scanning of stained SDS-PAGE gels of the substrate, the proteases present in the supernatants of antigen-activated cells, but not of sensitized unchallenged cells, rapidly degraded native fibronectin at pH 7.0.	Sodium Dodecyl Sulfate	51-54	fibronectin 1	Mus musculus	219-230
6607119-5	1984	Similarly, after treatment of 3T3 cells with the tumor-promoter phorbol myristate acetate, which induces a transformation-like phenotype, the cells no longer respond to PDGF as a chemoattractant but retain their migratory response to fibronectin.	Tetradecanoylphorbol Acetate	64-89	fibronectin 1	Mus musculus	234-245
6239124-2	1984	Concentrations of Fn less than 30 micrograms/ml enhanced the growth rate of these cells as judged by 3H-thymidine incorporation, whereas higher levels of Fn were inhibitory.	3h-thymidine	101-113	fibronectin 1	Mus musculus	18-20
6832218-0	1983	Exogenous gangliosides enhance the interaction of fibronectin with ganglioside-deficient cells.	Gangliosides	10-22	fibronectin 1	Mus musculus	50-61
6686086-6	1983	The inhibitory effects of fibronectin can be reversed by keeping cells in a rounded configuration or by exposing cells to either cytochalasin D, which disrupts the actin cytoskeleton, or insulin, a key lipogenic hormone.	Cytochalasin D	129-143	fibronectin 1	Mus musculus	26-37
6222058-0	1983	Correlation between cell substrate attachment in vitro and cell surface heparan sulfate affinity for fibronectin and collagen.	Heparitin Sulfate	72-87	fibronectin 1	Mus musculus	101-112
6222058-3	1983	These latter heparan sulfates do, however, bind to both fibronectin and collagen, as reported earlier (Stamatoglou, S.C., and J.M.	Heparitin Sulfate	13-29	fibronectin 1	Mus musculus	56-67
6832218-0	1983	Exogenous gangliosides enhance the interaction of fibronectin with ganglioside-deficient cells.	Gangliosides	10-21	fibronectin 1	Mus musculus	50-61
6832218-1	1983	The major cell-surface glycoprotein fibronectin mediates a variety of cellular adhesive interactions that have been reported to be competitively inhibited by gangliosides.	Gangliosides	158-170	fibronectin 1	Mus musculus	36-47
6832218-2	1983	These effects suggest a possible function of gangliosides as receptors for fibronectin.	Gangliosides	45-57	fibronectin 1	Mus musculus	75-86
6832218-3	1983	To test this hypothesis more directly, we examined the interaction of endogenous fibronectin with a ganglioside-deficient cell line, NCTC 2071.	Gangliosides	100-111	fibronectin 1	Mus musculus	81-92
6832218-6	1983	When the cells were cultured in medium containing ganglioside, the fibronectin became bound to the cell surface in fibrillar strands.	Gangliosides	50-61	fibronectin 1	Mus musculus	67-78
6832218-10	1983	Our results support the hypothesis that gangliosides can help mediate the binding of fibronectin to fibroblasts.	Gangliosides	40-52	fibronectin 1	Mus musculus	85-96
6812947-0	1982	Stimulation of fibronectin production by retinoic acid in mouse skin tumors.	Tretinoin	41-54	fibronectin 1	Mus musculus	15-26
6959135-0	1982	Retinoids and phorbol esters alter release of fibronectin from enucleated cells.	Retinoids	0-9	fibronectin 1	Mus musculus	46-57
6959135-0	1982	Retinoids and phorbol esters alter release of fibronectin from enucleated cells.	Phorbol Esters	14-28	fibronectin 1	Mus musculus	46-57
6219115-0	1983	Cell surface heparan sulfate mediates some adhesive responses to glycosaminoglycan-binding matrices, including fibronectin.	Heparitin Sulfate	13-28	fibronectin 1	Mus musculus	111-122
6959135-2	1982	Over the same concentration range, 10(-9) to 10(-6) M, TPA induced the release of radioactively labeled fibronectin (FN) from the cells into the culture medium.	Tetradecanoylphorbol Acetate	55-58	fibronectin 1	Mus musculus	104-115
6959135-2	1982	Over the same concentration range, 10(-9) to 10(-6) M, TPA induced the release of radioactively labeled fibronectin (FN) from the cells into the culture medium.	Tetradecanoylphorbol Acetate	55-58	fibronectin 1	Mus musculus	117-119
6959135-3	1982	Retinoic acid, a derivative of vitamin A, inhibited in a dose-dependent manner both the increase in OrnDCase activity and the release of FN induced by TPA.	Tretinoin	0-13	fibronectin 1	Mus musculus	137-139
6959135-3	1982	Retinoic acid, a derivative of vitamin A, inhibited in a dose-dependent manner both the increase in OrnDCase activity and the release of FN induced by TPA.	Vitamin A	31-40	fibronectin 1	Mus musculus	137-139
6959135-3	1982	Retinoic acid, a derivative of vitamin A, inhibited in a dose-dependent manner both the increase in OrnDCase activity and the release of FN induced by TPA.	Tetradecanoylphorbol Acetate	151-154	fibronectin 1	Mus musculus	137-139
6959135-5	1982	In the enucleated cells, TPA did not induce increased OrnDCase activity but did induce FN release in a dose-dependent fashion over the same concentration range effective for FN release from intact cells.	Tetradecanoylphorbol Acetate	25-28	fibronectin 1	Mus musculus	87-89
6959135-5	1982	In the enucleated cells, TPA did not induce increased OrnDCase activity but did induce FN release in a dose-dependent fashion over the same concentration range effective for FN release from intact cells.	Tetradecanoylphorbol Acetate	25-28	fibronectin 1	Mus musculus	174-176
6959135-6	1982	Moreover, addition of retinoic acid to the enucleated cells inhibited the phorbol ester-induced release of FN in a dose-dependent manner.	Tretinoin	22-35	fibronectin 1	Mus musculus	107-109
6959135-6	1982	Moreover, addition of retinoic acid to the enucleated cells inhibited the phorbol ester-induced release of FN in a dose-dependent manner.	Phorbol Esters	74-87	fibronectin 1	Mus musculus	107-109
6959135-7	1982	A series of phorbol ester derivatives showed the same order of activity in causing FN release from the enucleated cells as reported for inducing OrnDcase activity in intact cells or in promoting mouse skin tumors in vivo.	Phorbol Esters	12-25	fibronectin 1	Mus musculus	83-85
6959135-8	1982	Similarly, several retinoids were tested for their ability to inhibit the phorbol ester-induced release of FN from enucleated cells.	Retinoids	19-28	fibronectin 1	Mus musculus	107-109
6959135-8	1982	Similarly, several retinoids were tested for their ability to inhibit the phorbol ester-induced release of FN from enucleated cells.	Phorbol Esters	74-87	fibronectin 1	Mus musculus	107-109
6959135-9	1982	The efficacy of the retinoids in preventing FN release paralleled their activity in inhibiting phorbol ester-induced OrnDCase activity and skin tumor promotion, as reported in the literature.	Retinoids	20-29	fibronectin 1	Mus musculus	44-46
6959135-10	1982	We conclude that at least one aspect of tumor promotion induced by phorbol esters--the loss of FN--does not require the cell nucleus, and further, that retinoids can inhibit this aspect of tumor promotion without nuclear involvement.	Phorbol Esters	67-81	fibronectin 1	Mus musculus	95-97
33786627-7	2021	Moreover, compared with the control group, matrine significantly inhibited ovarian cancer cell viability, migration and invasion by downregulating metastasis associated protein-1, fibronectin, angiotensin II type 2 receptor-interacting protein 3a and H high mobility group AT-hook 2 expression levels.	matrine	43-50	fibronectin 1	Mus musculus	180-191
6749839-6	1982	Fibronectin and collagen were detected on the bases of their relative mobilities, differential labeling with 3H-versus 35S-labeled amino acids and their solubilization by protease free collagenase.	Tritium	109-111	fibronectin 1	Mus musculus	0-11
6749839-6	1982	Fibronectin and collagen were detected on the bases of their relative mobilities, differential labeling with 3H-versus 35S-labeled amino acids and their solubilization by protease free collagenase.	Sulfur-35	119-122	fibronectin 1	Mus musculus	0-11
198786-6	1977	Analysis of biosynthetically labeled proteins showed that a high-molecular-weight protein, presumed to be related to fibronectin, is markedly reduced in the medium of cells cultured in the presence of tunicamycin.	Tunicamycin	201-212	fibronectin 1	Mus musculus	117-128
32814818-8	2021	Transfection with miR-99b-3p mimic resulted in the overproduction of fibronectin, collagen I, vimentin and alpha-SMA, and facilitated the proliferation and migration of CFs.	mir-99b-3p	18-28	fibronectin 1	Mus musculus	69-80
33635167-10	2021	Notably, exercise normalized BAPN-induced increases in TGFbeta pathway related genes Cd109, Smad4, and Tgfbetar1, inflammation related genes Vcam1, Bcl2a1, Ccr2, Pparg, Il1r1, Il1r1, Itgb2, and Itgax, as well as vascular injury and response related genes Mmp3, Fn1, and Vwf.	Aminopropionitrile	29-33	fibronectin 1	Mus musculus	261-264
7171625-0	1982	Interactions of cellular glycosaminoglycans with plasma fibronectin and collagen.	Glycosaminoglycans	25-43	fibronectin 1	Mus musculus	56-67
7171625-1	1982	The interactions of metabolically radiolabelled glycosaminoglycans, isolated from Swiss mouse 3T3 and SV3T3 cells, with plasma fibronectin and collagen were studied by affinity column chromatograph in Hepes-buffered saline (150 mM NaCl in 10 mM Hepes buffer).	Glycosaminoglycans	48-66	fibronectin 1	Mus musculus	127-138
7171625-6	1982	Reference standard chondroitin 4-sulfate and chondroitin 6-sulfate had no effect upon heparan sulfate binding, whereas 90% of the heparan sulfate bound to fibronectin or collagen was eluted with heparin and 60% removed from fibronectin with dermatan sulfate.	Heparitin Sulfate	130-145	fibronectin 1	Mus musculus	155-166
7328676-4	1981	Tunicamycin-treated B16-F1 and B16-F10 cells lost their lung colonization abilities when injected intravenously into C57BL/6 mice, concomitant with lowered rates of adhesion to endothelial cell monolayers, endothelial extracellular matrix (basal lamina), and polyvinyl-immobilized fibronectin in vitro, suggesting that this drug inhibits experimental metastasis by modifying the surface glycoproteins involved in determining the adhesive properties of malignant cells.	Tunicamycin	0-11	fibronectin 1	Mus musculus	281-292
6256752-9	1980	Because these fibroblast adhesion sites do not contain collagen, which could potentially mediate adhesion to the substratum-bound CIg, these data support other evidence that multivalent heparan sulfate proteoglycans mediate substratum adhesion of these cells by coordinate binding to fibronectin on the cell surface and CIg on the substratum.	Heparitin Sulfate	186-201	fibronectin 1	Mus musculus	284-295
33837955-11	2021	In addition, the enhancement of PAR1 activity by GB83 strongly increased gene expression of TGF-beta, fibronectin and type I collagen in vitro, and promoted skin wound healing in vivo.	gb83	49-53	fibronectin 1	Mus musculus	102-113
33098939-8	2021	As displayed by Safranin-fast green staining hematoxylin-eosin staining, the overexpression of FN1 at fracture site promoted osteoid formation and chondrocyte differentiation.	safranin-fast green	16-35	fibronectin 1	Mus musculus	95-98
33746143-5	2021	The results indicated that fibronectin, vitronectin, or laminin coating was necessary for adhesion of TSCs under KSR-based conditions but not for their survival or proliferation.	ksr	113-116	fibronectin 1	Mus musculus	27-38
33507617-7	2021	In UUO mice, BPP treatment could significantly alleviate interstitial fibrosis through reducing the components (Collagens I, III and IV) of extracellular matrix (ECM), and reducing the activation of fibroblasts producing these components, as revealed by inhibiting the hallmarks (fibronectin and alpha-SMA) of fibroblast activation.	bpp	13-16	fibronectin 1	Mus musculus	280-291
33301900-3	2021	In both cases, treatment with SLM6031434 or HWG-35D resulted in an attenuated fibrotic response to UUO in comparison to vehicle-treated mice as demonstrated by reduced collagen accumulation and a decreased expression of collagen-1 (Col1), fibronectin-1 (FN-1), connective tissue growth factor (CTGF), and alpha-smooth muscle actin (alpha-SMA).	slm6031434	30-40	fibronectin 1	Mus musculus	239-252
33301900-3	2021	In both cases, treatment with SLM6031434 or HWG-35D resulted in an attenuated fibrotic response to UUO in comparison to vehicle-treated mice as demonstrated by reduced collagen accumulation and a decreased expression of collagen-1 (Col1), fibronectin-1 (FN-1), connective tissue growth factor (CTGF), and alpha-smooth muscle actin (alpha-SMA).	slm6031434	30-40	fibronectin 1	Mus musculus	254-258
33301900-5	2021	Treatment of primary renal fibroblasts with SLM6031434 or HWG-35D dose-dependently increased Smad7 expression and ameliorated the expression of Col1, FN-1 and CTGF.	slm6031434	44-54	fibronectin 1	Mus musculus	150-154
33098939-8	2021	As displayed by Safranin-fast green staining hematoxylin-eosin staining, the overexpression of FN1 at fracture site promoted osteoid formation and chondrocyte differentiation.	Hematoxylin	45-56	fibronectin 1	Mus musculus	95-98
33098939-8	2021	As displayed by Safranin-fast green staining hematoxylin-eosin staining, the overexpression of FN1 at fracture site promoted osteoid formation and chondrocyte differentiation.	Eosine Yellowish-(YS)	57-62	fibronectin 1	Mus musculus	95-98
33614642-7	2021	Expressions of inflammatory markers MCP-1, F4/80 and ICAM, fibrotic markers type IV collagen and fibronectin, and the cytokine TGF-beta1 were increased in adenine-induced CKD when compared to control groups and significantly attenuated by metformin treatment.	Adenine	155-162	fibronectin 1	Mus musculus	97-108
33564685-12	2021	Moreover, FSK treatment in diabetic mice decreased the expression of fibronectin, collagen I, TGF-beta, and alpha-SMA and reduced myocardial fibrosis.	Colforsin	10-13	fibronectin 1	Mus musculus	69-80
32691413-8	2021	MiR-27a-3p silencing ameliorated renal fibrosis, reflected by reduced profibrogenic genes (e.g., transforming growth factor beta1, fibronectin, collagen I and III, and alpha-smooth muscle actin).	mir-27a-3p	0-10	fibronectin 1	Mus musculus	131-142
32948825-8	2021	In db/db mice, TUG-891 administration significantly inhibited the mRNA and protein expression of fibronectin, collagen IV, alpha-SMA, TGF-beta1, and IL-6, and downregulated the phosphorylation of Smad3 and STAT3 to alleviate glomerulosclerosis.	3-(4-((4-fluoro-4'-methyl-(1,1'-biphenyl)-2-yl)methoxy)phenyl)propanoic acid	15-22	fibronectin 1	Mus musculus	97-108
33509285-7	2021	RESULTS: LF82 administration exacerbated fibrosis in DSS-treated mice, revealed by increased colonic collagen deposition and expression of the profibrotic genes Col1a1, Col3a1, Fn1 and Vim.	lf82	9-13	fibronectin 1	Mus musculus	177-180
33509285-7	2021	RESULTS: LF82 administration exacerbated fibrosis in DSS-treated mice, revealed by increased colonic collagen deposition and expression of the profibrotic genes Col1a1, Col3a1, Fn1 and Vim.	Dextran Sulfate	53-56	fibronectin 1	Mus musculus	177-180
33633440-7	2021	The effects of ATX and LPA indicated the time-dependent difference in the upregulation of alpha-SMA, COL1A1, and fibronectin.	lysophosphatidic acid	23-26	fibronectin 1	Mus musculus	113-124
33639057-9	2021	Propofol exerts effect in inhibiting ET-1 and fibronectin expression and the formation of ROS induced by Ag II.	Propofol	0-8	fibronectin 1	Mus musculus	46-57
33082140-8	2020	Similarly, rosiglitazone increased miR-98 and reversed nicotine-induced increases in NGF, FN1, and ET-1.	Rosiglitazone	11-24	fibronectin 1	Mus musculus	90-93
33082140-8	2020	Similarly, rosiglitazone increased miR-98 and reversed nicotine-induced increases in NGF, FN1, and ET-1.	Nicotine	55-63	fibronectin 1	Mus musculus	90-93
32504027-6	2020	Meanwhile, the increased protein expression levels of Fibronectin and alpha-SMA under high glucose conditions were reversed by loss of SNHG16.	Glucose	91-98	fibronectin 1	Mus musculus	54-65
33294462-11	2020	Results: Paricalcitol treatment restored villin, nephrin, and podocin protein levels that were downregulated upon DM induction, and reduced fibronectin protein level.	paricalcitol	9-21	fibronectin 1	Mus musculus	140-151
33007732-10	2020	Withaferin A could significantly reverse the increases in the protein levels of pro-fibrotic factors (fibronectin, transforming growth factor-beta, and alpha-smooth muscle actin), inflammatory signaling molecules (phosphorylated nuclear factor-kappaB-p65, interleukin-1beta, and cyclooxygenase-2), and cleaved caspase-3, apoptosis, and infiltration of neutrophils in the UUO kidneys.	withaferin A	0-12	fibronectin 1	Mus musculus	102-113
33294462-13	2020	Conclusions: Paricalcitol treatment was associated with improved structural changes in type 1 diabetic mice including upregulation of vitamin D receptor expression, and decreased fibrosis markers such as fibronectin.	paricalcitol	13-25	fibronectin 1	Mus musculus	204-215
33152903-7	2020	Meanwhile, Marein ameliorated fibrosis and inflammation by suppressing the pro-inflammatory factors interleukin-6 (IL-6) and monocyte chemotactic protein-1 (MCP-1), and expression of the extracellular matrix proteins, fibronectin (FN) and collagen 1 (COL1) in diabetic mice.	marein	11-17	fibronectin 1	Mus musculus	218-229
33239075-8	2020	The results showed that the gene expression of collagen I (COL1A1) and fibronectin (FN) was upregulated in the silica group as compared to that in the control group; however, this change decreased with hucMSC-Exo treatment.	Silicon Dioxide	111-117	fibronectin 1	Mus musculus	71-82
33239075-8	2020	The results showed that the gene expression of collagen I (COL1A1) and fibronectin (FN) was upregulated in the silica group as compared to that in the control group; however, this change decreased with hucMSC-Exo treatment.	Silicon Dioxide	111-117	fibronectin 1	Mus musculus	84-86
33238581-6	2020	Moreover, M2 macrophages differentiated with calcitriol-stimulated migration of 4T1 and 67NR cells through fibronectin and collagen type IV, respectively.	Calcitriol	45-55	fibronectin 1	Mus musculus	107-118
33292650-11	2020	By day 14, hCSSC treatment significantly reduced the expression of fibrotic and scar tissue genes (fibronectin, hyaluronan synthase 2, Secreted protein acidic and cysteine rich, tenascin C, collagen 3a1 and alpha-smooth muscle actin), and the injured corneas remained clear.	hcssc	11-16	fibronectin 1	Mus musculus	99-110
33323915-18	2020	Furthermore, paclitaxel suppressed the palmitate-induced fibrosis molecules, fibronectin and TGF-ss1.	Paclitaxel	13-23	fibronectin 1	Mus musculus	77-88
33152903-7	2020	Meanwhile, Marein ameliorated fibrosis and inflammation by suppressing the pro-inflammatory factors interleukin-6 (IL-6) and monocyte chemotactic protein-1 (MCP-1), and expression of the extracellular matrix proteins, fibronectin (FN) and collagen 1 (COL1) in diabetic mice.	marein	11-17	fibronectin 1	Mus musculus	231-233
32939821-8	2020	Meanwhile, compound A and sildenafil significantly suppressed the UACR, urinary kidney injury molecule-1, and monocyte chemoattractant protein-1 levels, as well as that of renal pro-fibrotic marker mRNAs, including collagen 1A1, fibronectin, and transforming growth factor-beta (TGF-beta).	Sildenafil Citrate	26-36	fibronectin 1	Mus musculus	229-240
32449990-9	2020	Finally, silencing of galectin-8 in NIH3T3 cells abolished cyclosporine-induced fibronectin protein levels.	Cyclosporine	59-71	fibronectin 1	Mus musculus	80-91
32927253-8	2020	Importantly, indirubin provided protection for mice against BLM-induced pulmonary fibrosis as manifested by the attenuating expression of fibrotic hallmarks, including fibronectin, collagen I and alpha-smooth muscle actin (alpha-SMA).	indirubin	13-22	fibronectin 1	Mus musculus	168-179
32882664-6	2020	Furthermore, we found that PL treatment greatly inhibited HSCs activation and ECM deposition via downregulation of fibronectin, alpha-SMA, collagen1a, and collagen3a expression in the fibrotic livers.	piperlonguminine	27-29	fibronectin 1	Mus musculus	115-126
33194415-3	2020	We constructed a tamoxifen-induced conditional (cre-loxp system) fibronectin knock-out (FnKO) mouse model on a C57BL/6 background, and monitored their behavior, fertility, histological, hematopoietic, biochemical and immunological indices.	Tamoxifen	17-26	fibronectin 1	Mus musculus	65-76
32758941-6	2020	BaP exposure enhanced bleomycin (BLM)-induced murine pulmonary fibrosis with increased Fibronectin and alpha-SMA expression in primary fibroblasts, thickened respiratory membrane and damaged alveolar type II cell, combined with Gprc5a decline in fibrotic mass.	Benzo(a)pyrene	0-3	fibronectin 1	Mus musculus	87-98
32715764-9	2020	Notably, the exosomes from high glucose conditioned BUMPT cells (HG-Exo) induced higher proliferation, significant morphologic change, and substantial production of fibronectin, a-SMA and collagen I in fibroblasts.	Glucose	32-39	fibronectin 1	Mus musculus	165-176
32372165-6	2020	Additionally, treatment with TA also impaired BLM-mediated increases in pro-fibrotic (transforming growth factor-beta1) and fibrotic markers (alpha-smooth muscle actin, vimentin, collagen 1 alpha and fibronectin) expression.	Tannins	29-31	fibronectin 1	Mus musculus	200-211
32799885-5	2020	RESULTS: O-PMs treatment induced EMT development, fibronectin expression, and cell migration.	o-pms	9-14	fibronectin 1	Mus musculus	50-61
32721432-5	2020	BR treatment also prevented cerulein-induced pancreatic stellate cells (PSCs) activation and extracellular matrix (ECM) deposition via downregulation of alpha-SMA, collagen1a, collagen3a and fibronectin expression.	Berberine	0-2	fibronectin 1	Mus musculus	191-202
32304410-4	2020	In this article, we describe combination treatments of a tumor-targeting antibody-cytokine fusion protein based on the L19 antibody (specific to a splice isoform of fibronectin) fused to murine tumor necrosis factor with standard chemotherapy (dacarbazine, trabectedin or melphalan) or with an immune check-point inhibitor (anti-PD-1) in a BALB/c derived immunocompetent murine model of sarcoma (WEHI-164).	Dacarbazine	244-255	fibronectin 1	Mus musculus	165-176
32739204-5	2020	Knockdown of DcR2 decreased the expression of alpha-smooth muscle actin, collagen I, fibronectin and serum creatinine levels in streptozotocin-induced mice.	Streptozocin	128-142	fibronectin 1	Mus musculus	85-96
32822410-2	2020	Using a fibronectin-binding peptide called FUD that can disrupt fibronectin fibrillogenesis, we examined if disrupting fibronectin fibrillogenesis would affect IOP in the TGFbeta2 BALB/cJ mouse model of ocular hypertension.	D-(-)-Fructose	43-46	fibronectin 1	Mus musculus	8-19
32822410-2	2020	Using a fibronectin-binding peptide called FUD that can disrupt fibronectin fibrillogenesis, we examined if disrupting fibronectin fibrillogenesis would affect IOP in the TGFbeta2 BALB/cJ mouse model of ocular hypertension.	D-(-)-Fructose	43-46	fibronectin 1	Mus musculus	64-75
32822410-2	2020	Using a fibronectin-binding peptide called FUD that can disrupt fibronectin fibrillogenesis, we examined if disrupting fibronectin fibrillogenesis would affect IOP in the TGFbeta2 BALB/cJ mouse model of ocular hypertension.	D-(-)-Fructose	43-46	fibronectin 1	Mus musculus	64-75
32910199-5	2020	The results showed that the mice fed emodin presented decreases in the urinary protein content and glomerular TNF-alpha, ICAM-1 and FN levels (P<0.05).	Emodin	37-43	fibronectin 1	Mus musculus	132-134
33543041-1	2020	Mesangial cells are the major extracellular matrix (ECM)-producing cells in the kidney glomerulus and, when exposed to elevated glucose levels, they up-regulate assembly of fibronectin (FN) and other ECM proteins.	Glucose	128-135	fibronectin 1	Mus musculus	173-184
32994028-2	2020	We previously showed that poly(epsilon)caprolactone (PCL) films functionalized with adhesive peptides containing sequences of both cell binding domain (RGD) and synergistic site (PHSRN) of the fibronectin (pFibro) enhanced the osteoblastic commitment of C3H10T1/2 mesenchymal progenitor cells (C3H10T1/2 cells) induced by soluble BMP-9 or its derived peptide SpBMP-9.	Peptides	93-101	fibronectin 1	Mus musculus	193-204
32994028-2	2020	We previously showed that poly(epsilon)caprolactone (PCL) films functionalized with adhesive peptides containing sequences of both cell binding domain (RGD) and synergistic site (PHSRN) of the fibronectin (pFibro) enhanced the osteoblastic commitment of C3H10T1/2 mesenchymal progenitor cells (C3H10T1/2 cells) induced by soluble BMP-9 or its derived peptide SpBMP-9.	spbmp-9	359-366	fibronectin 1	Mus musculus	193-204
32799885-8	2020	In addition, O-PMs affected the expression of fibronectin, E-cadherin, and vimentin through modulating ETS-1 expression.	o-pms	13-18	fibronectin 1	Mus musculus	46-57
32799885-9	2020	ATN-161, an antagonist of integrin alpha5beta1, decreased the expression of fibronectin and ETS-1 and EMT development.	acetyl-prolyl-histidyl-seryl-cysteinyl-asparaginamide	0-7	fibronectin 1	Mus musculus	76-87
32788339-7	2020	The abundance of circulating o,o"-dityrosine-modified fibronectin was increased in a murine model of lung fibrosis and in human subjects with interstitial lung disease compared to that in control healthy subjects.	dityrosine	29-44	fibronectin 1	Mus musculus	54-65
31855314-8	2020	In normal mice, rosuvastatin increased CK, TNF-alpha (heart), NF-kB (diaphragm) and fibronectin (heart and diaphragm).	rosuvastatin	16-28	fibronectin 1	Mus musculus	84-95
32428545-8	2020	At days 28 and 84, the protein expression of fibronectin and col1a1 decreased in the silica + anti-HMGB-1 groups but increased in silica + rmHMGB-1 groups compared to mice with silica alone.	Silicon Dioxide	85-91	fibronectin 1	Mus musculus	45-56
32535538-4	2020	Immunofluorescence analysis reveals that the natural spice curcumin blocks the expressions of COX-2, NF-kappaB-p65, fibronectin (FBN), and expresses P-AMPKalpha in vivo.	Curcumin	59-67	fibronectin 1	Mus musculus	116-127
32535538-4	2020	Immunofluorescence analysis reveals that the natural spice curcumin blocks the expressions of COX-2, NF-kappaB-p65, fibronectin (FBN), and expresses P-AMPKalpha in vivo.	Curcumin	59-67	fibronectin 1	Mus musculus	129-132
32702718-9	2020	Additionally, sub-chronic e-cig exposure with or without nicotine altered the abundance of ECM proteins, such as collagen and fibronectin significantly in a sex-dependent manner, but without the direct role of nAChR alpha7 gene.	Nicotine	57-65	fibronectin 1	Mus musculus	126-137
32509163-6	2020	Melatonin also reduced collagen type IV, fibronectin, transforming growth factor-beta1 (TGF-beta1) and decreased the phosphorylation of Smad3 in the renal tissue.	Melatonin	0-9	fibronectin 1	Mus musculus	41-52
32669976-8	2020	Nicotine treatment also increased E-cadherin and ZO-1 and decreased fibronectin and vimentin expression.	Nicotine	0-8	fibronectin 1	Mus musculus	68-79
32552811-9	2020	Additionally, sub-chronic e-cig exposure with or without nicotine altered the abundance of ECM proteins, such as collagen and fibronectin, significantly in a sex-dependent manner, but without the direct role of nAChRalpha7 gene.	Nicotine	57-65	fibronectin 1	Mus musculus	126-137
32428545-8	2020	At days 28 and 84, the protein expression of fibronectin and col1a1 decreased in the silica + anti-HMGB-1 groups but increased in silica + rmHMGB-1 groups compared to mice with silica alone.	Silicon Dioxide	130-136	fibronectin 1	Mus musculus	45-56
32428545-8	2020	At days 28 and 84, the protein expression of fibronectin and col1a1 decreased in the silica + anti-HMGB-1 groups but increased in silica + rmHMGB-1 groups compared to mice with silica alone.	Silicon Dioxide	130-136	fibronectin 1	Mus musculus	45-56
32499696-5	2020	NR_136400 downregulation facilitated EMT by inhibiting the expression of E-cadherin and elevating the expression of ZEB1, Snail, and fibronectin.	nr_136400	0-9	fibronectin 1	Mus musculus	133-144
32146192-7	2020	During incubation with SE-PA epithelial cells underwent conversion and assumed fibroblast phenotype characterized by a decrease in epithelial cells markers (CDH1, CLDN1, JUP) and increase in mesenchymal cells markers (FN1, VIM, CDH2).	se-pa	23-28	fibronectin 1	Mus musculus	218-221
32563017-9	2020	Notably, Kaempferol showed the potential to ameliorate the histological changes as well as renal fibrosis while decreasing the expression levels of DN markers including TGF-beta1, CTGF, fibronectin, collagen IV, IL-1beta, RhoA, ROCK2, and p-MYPT1 in DN kidney tissues.	kaempferol	9-19	fibronectin 1	Mus musculus	186-197
32377396-3	2020	In the present study, we first discovered that the ECM component fibronectin was reduced in the pulmonary tissues of model mice with BPD induced by lipopolysaccharide (LPS) and hyper-oxygen.	hyper-oxygen	177-189	fibronectin 1	Mus musculus	65-76
31804606-7	2020	We further revealed that GA treatment inhibited the extracellular matrix (ECM) deposition in the kidney by suppressing the expression of fibronectin, mainly through hindering the over activation of TGF-beta/Smad signaling.	ganoderic acid	25-27	fibronectin 1	Mus musculus	137-148
31884830-5	2020	The content of hydroxyproline and TGF-beta1 was decreased by downregulating the expression of miR-182-5p, indicating that fibrosis was alleviated in mice treated with Lentivirus-anti-miR-182-5p.Quantification of fibrosis-related proteins demonstrated that downregulation of miR-182-5p inhibited the expression of profibrotic proteins (fibronectin, alpha-smooth muscle actin, p-Smad2/p-Smad3) as well as enhanced the level of Smad7.	bradykinin, hydroxy-Pro(3)-	15-29	fibronectin 1	Mus musculus	335-346
32068386-5	2020	For one thing, it was found that the introduction of the disulfide bond in the PLGA hydrogel promoted cellular adhesion via combining fibronectin, preventing the formation of spheroids, while the introduction of polyethylene glycol monomethyl ether (mPEG) could disturb the effect of the disulfide bond on cellular adhesion, supporting spheroid formation inside the porous hydrogel.	Disulfides	57-66	fibronectin 1	Mus musculus	134-145
32280219-7	2020	We observed that water-soluble C60 can alleviate the severity of pulmonary fibrosis by observing the chest computed tomography, pulmonary pathology, and content of collagen, alpha smooth muscle actin and fibronectin in lung.	Water	17-22	fibronectin 1	Mus musculus	204-215
32197572-0	2020	Electrochemical quartz crystal microbalance with dissipation investigation of fibronectin adsorption dynamics driven by electrical stimulation onto a conducting and partially biodegradable copolymer.	copolymer	189-198	fibronectin 1	Mus musculus	78-89
32197572-7	2020	Additionally, FN binds to the copolymer interface in an unfolded conformation, which can promote better NIH-3T3 fibroblast cell adhesion and later cell development.	copolymer	30-39	fibronectin 1	Mus musculus	14-16
32349726-9	2020	Upon bleomycin treatment, quercetin-fed mice displayed reduced expression of collagen (COL1A2) and fibronectin (FN1) and a tendency of reduced inflammatory lesions (2.8 +- 0.7 versus 1.9 +- 0.8).	Bleomycin	5-14	fibronectin 1	Mus musculus	99-110
32349726-9	2020	Upon bleomycin treatment, quercetin-fed mice displayed reduced expression of collagen (COL1A2) and fibronectin (FN1) and a tendency of reduced inflammatory lesions (2.8 +- 0.7 versus 1.9 +- 0.8).	Bleomycin	5-14	fibronectin 1	Mus musculus	112-115
32349726-9	2020	Upon bleomycin treatment, quercetin-fed mice displayed reduced expression of collagen (COL1A2) and fibronectin (FN1) and a tendency of reduced inflammatory lesions (2.8 +- 0.7 versus 1.9 +- 0.8).	Quercetin	26-35	fibronectin 1	Mus musculus	99-110
32349726-9	2020	Upon bleomycin treatment, quercetin-fed mice displayed reduced expression of collagen (COL1A2) and fibronectin (FN1) and a tendency of reduced inflammatory lesions (2.8 +- 0.7 versus 1.9 +- 0.8).	Quercetin	26-35	fibronectin 1	Mus musculus	112-115
32455066-4	2020	We show that 1) Dex significantly reduces z-axis penetration of glioblastoma cells into mouse retina; 2) treatment alters the morphology of dispersal; 3) without Dex, the presence of fibronectin increases dispersal; 4) treatment activates in vivo FNMA by glioblastoma cells, leading to the containment of the tumor mass; and 5) Dex-mediated activation of FNMA is fibronectin dose-dependent.	Dexamethasone	16-19	fibronectin 1	Mus musculus	183-194
32455066-4	2020	We show that 1) Dex significantly reduces z-axis penetration of glioblastoma cells into mouse retina; 2) treatment alters the morphology of dispersal; 3) without Dex, the presence of fibronectin increases dispersal; 4) treatment activates in vivo FNMA by glioblastoma cells, leading to the containment of the tumor mass; and 5) Dex-mediated activation of FNMA is fibronectin dose-dependent.	Dexamethasone	16-19	fibronectin 1	Mus musculus	363-374
31904865-0	2020	Ovarian cancer-associated mesothelial cells induce acquired platinum-resistance in peritoneal metastasis via the FN1/Akt signaling pathway.	Platinum	60-68	fibronectin 1	Mus musculus	113-116
31904865-8	2020	Mechanistically, OCAMs can induce decreased platinum-sensitivity in OvCa cells via induction of the FN1/Akt signaling pathway via cell-to-cell interactions.	Platinum	44-52	fibronectin 1	Mus musculus	100-103
31931051-0	2020	Targeted delivery of celastrol to renal interstitial myofibroblasts using fibronectin-binding liposomes attenuates renal fibrosis and reduces systemic toxicity.	celastrol	21-30	fibronectin 1	Mus musculus	74-85
32411754-15	2020	Additionally, a reduction in ECM components fibronectin, collagen IV, matrix metallopeptidase 16, and Tenascin C was detected after DEX treatment, but was prohibited when TMPRSS2 or Rab11 were knocked down.	Dexmedetomidine	132-135	fibronectin 1	Mus musculus	44-55
32355512-4	2020	Overexpression of miR-19 could decrease the expression of E-cadherin and increase the expression of alpha-SMA and fibronectin, while inhibition of miR-19 reverses TGF-beta1-induced EMT.	mir-19	18-24	fibronectin 1	Mus musculus	114-125
32269725-7	2020	Our study showed that intratracheal injection of bleomycin induced pulmonary fibrosis in mice, with observed elevation in collagen, fibronectin and alpha-SMA level, characterized by the enhanced IGF-1 and PI3K expression.	Bleomycin	49-58	fibronectin 1	Mus musculus	132-143
31250885-12	2020	In co-culture systems, TRPM7+/Deltakinase macrophages increased expression of fibronectin, PCNA, and TGFbeta in cardiac fibroblasts from wildtype mice, effects ameliorated by MgCl2 treatment.	Magnesium Chloride	175-180	fibronectin 1	Mus musculus	78-89
32075634-9	2020	Furthermore, curdione also decreased TGF-beta1 induced fibroblast to myofibroblast differentiation in vitro, as evidenced by low expression of alpha-SMA, collagen 1 and fibronectin in a dose dependent manner.	curdione	13-21	fibronectin 1	Mus musculus	169-180
32190663-7	2020	DOCA-hypertensive mice also exhibited an increase in the vascular oxidative fluorescence intensities, the protein expressions of gp91phox and p22phox, and the fibrotic factors transforming growth factor beta and fibronectin.	Desoxycorticosterone Acetate	0-4	fibronectin 1	Mus musculus	212-223
31854234-11	2020	Upregulation of fibronectin was found in both TM cells treated with dexamethasone for 14 days and murine TM tissues damaged by laser photocoagulation.	Dexamethasone	68-81	fibronectin 1	Mus musculus	16-27
32069798-7	2020	Both NIH3T3 and A549 cells adhered to heparin/chitosan (HEP/CHI) film because HEP has an affinity for integrin through fibronectin.	Heparin	38-45	fibronectin 1	Mus musculus	119-130
32296050-3	2020	In this study, we built an dual-acting therapeutic strategy using micelles with high stability functionalized with fibronectin-targeting CREKA peptides encapsulating two slightly soluble chemotherapy agents in water, doxorubicin (D) and vinorelbine (V), which we termed C-DVM.	Water	210-215	fibronectin 1	Mus musculus	115-126
32296050-3	2020	In this study, we built an dual-acting therapeutic strategy using micelles with high stability functionalized with fibronectin-targeting CREKA peptides encapsulating two slightly soluble chemotherapy agents in water, doxorubicin (D) and vinorelbine (V), which we termed C-DVM.	Doxorubicin	217-228	fibronectin 1	Mus musculus	115-126
32296050-3	2020	In this study, we built an dual-acting therapeutic strategy using micelles with high stability functionalized with fibronectin-targeting CREKA peptides encapsulating two slightly soluble chemotherapy agents in water, doxorubicin (D) and vinorelbine (V), which we termed C-DVM.	Vinorelbine	237-248	fibronectin 1	Mus musculus	115-126
32076626-10	2020	Furthermore, mangiferin treatment prevented renal interstitial fibrosis evidenced by decreases in the positive expression of FN, Col I, and alpha-SMA, in comparison with morphological changes in the renal tissue.	mangiferin	13-23	fibronectin 1	Mus musculus	125-127
31760766-9	2020	RNA-seq analysis revealed that alcohol feeding increases expression of markers for tumors (Epcam, Krt19, Prom1, Wt1, and Wwtr1), stroma (Dcn, Fn1, and Tnc), and cytokines (Tgfb1 and Tnf) and decreases expression of Fgf21 and Il6 in the pancreatic tumor tissues.	Alcohols	31-38	fibronectin 1	Mus musculus	142-145
31411705-11	2020	Because exposure of cardiomyocytes to TMAO increased fibronectin expression, these data suggest that linaclotide reduced the levels of TMAO and various uremic toxins and may result in not only renal, but also cardiac, fibrosis.	linaclotide	101-112	fibronectin 1	Mus musculus	53-64
32076626-13	2020	These findings demonstrate that mangiferin may reduce inflammation and oxidative stress in DN, thereby inhibiting the renal interstitial fibrosis by reducing the TGF-beta1-mediated elevation of Col I, FN, and alpha-SMA through the PTEN/PI3K/Akt pathway.	mangiferin	32-42	fibronectin 1	Mus musculus	201-203
31849504-10	2019	Western blotting and RT-qPCR data also revealed UA-induced decreases in the renal levels of the ARAP1, AT1, NOX4, NOX2, TGF-beta1, FN, collagen IV, IL-1beta and IL-18 proteins in vivo and/or in vitro (p&lt;0.01).	ursolic acid	48-50	fibronectin 1	Mus musculus	131-133
31759089-4	2020	In this study, we found that GPS significantly reversed the downregulation of TGR5 and inhibited the overproduction of fibronectin (FN), transforming growth factor beta1 (TGF-beta1), intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) in glomerular mesangial cells (GMCs) exposed to high glucose (HG).	gentiopicroside	29-32	fibronectin 1	Mus musculus	119-130
31759089-4	2020	In this study, we found that GPS significantly reversed the downregulation of TGR5 and inhibited the overproduction of fibronectin (FN), transforming growth factor beta1 (TGF-beta1), intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) in glomerular mesangial cells (GMCs) exposed to high glucose (HG).	gentiopicroside	29-32	fibronectin 1	Mus musculus	132-134
31765841-1	2020	The acute phase reactant C-reactive protein (CRP) binds with high affinity to fibronectin (FN), but this binding occurs only at pH 6.5 or lower, and the binding is inhibited by calcium ions at physiological pH.	Calcium	177-184	fibronectin 1	Mus musculus	78-89
31765841-1	2020	The acute phase reactant C-reactive protein (CRP) binds with high affinity to fibronectin (FN), but this binding occurs only at pH 6.5 or lower, and the binding is inhibited by calcium ions at physiological pH.	Calcium	177-184	fibronectin 1	Mus musculus	91-93
31950023-11	2019	Additionally, DHA inhibited cerulein-induced fibrotic mediators like alpha-smooth muscle actin and fibronectin in pancreas.	Docosahexaenoic Acids	14-17	fibronectin 1	Mus musculus	99-110
31950023-11	2019	Additionally, DHA inhibited cerulein-induced fibrotic mediators like alpha-smooth muscle actin and fibronectin in pancreas.	Ceruletide	28-36	fibronectin 1	Mus musculus	99-110
31639302-10	2019	Functionalization of graphene foam with fibronectin modified the cellular response to graphene foam, demonstrated by decreases in relative gene expression levels.	Graphite	21-29	fibronectin 1	Mus musculus	40-51
30905239-9	2019	However, UA treatment significantly reduced collagen I and fibronectin accumulation in the fibrotic kidney.	ursolic acid	9-11	fibronectin 1	Mus musculus	59-70
31639302-3	2019	The aim of this study was to determine if cell attachment and elaboration of an extracellular matrix would be modulated by functionalization of graphene foam with fibronectin, an extracellular matrix protein that cells adhere well to, prior to the establishment of three-dimensional cell culture.	Graphite	144-152	fibronectin 1	Mus musculus	163-174
31639302-4	2019	The molecular dynamic simulation demonstrated that the fibronectin-graphene interaction was stabilized predominantly through interaction between the graphene and arginine side chains of the protein.	Graphite	67-75	fibronectin 1	Mus musculus	55-66
31639302-4	2019	The molecular dynamic simulation demonstrated that the fibronectin-graphene interaction was stabilized predominantly through interaction between the graphene and arginine side chains of the protein.	Graphite	149-157	fibronectin 1	Mus musculus	55-66
31639302-4	2019	The molecular dynamic simulation demonstrated that the fibronectin-graphene interaction was stabilized predominantly through interaction between the graphene and arginine side chains of the protein.	Arginine Vasopressin	162-170	fibronectin 1	Mus musculus	55-66
31639302-5	2019	Quasi-static and dynamic mechanical testing indicated that fibronectin functionalization of graphene altered the mechanical properties of graphene foam.	Graphite	92-100	fibronectin 1	Mus musculus	59-70
31639302-5	2019	Quasi-static and dynamic mechanical testing indicated that fibronectin functionalization of graphene altered the mechanical properties of graphene foam.	Graphite	138-146	fibronectin 1	Mus musculus	59-70
31639302-7	2019	An additive effect was observed in the mechanical stiffness when the graphene foam was both coated with fibronectin and cultured with cells for 28 days.	Graphite	69-77	fibronectin 1	Mus musculus	104-115
31216372-8	2019	Unlike their myeloid progenitors, NLC produced H2 O2 when adhered to fibronectin, migrated toward chemotactic peptides, phagocytosed opsonized particles, and generated intracellular ROS.	Hydrogen Peroxide	47-52	fibronectin 1	Mus musculus	69-80
31639302-10	2019	Functionalization of graphene foam with fibronectin modified the cellular response to graphene foam, demonstrated by decreases in relative gene expression levels.	Graphite	86-94	fibronectin 1	Mus musculus	40-51
31361542-4	2019	The GSK4529 treatment also attenuated alterations in renal tubular expressions of E-cad1 and matrix protein fibronectin.	gsk4529	4-11	fibronectin 1	Mus musculus	108-119
31485676-11	2019	In addition, piperine treatment reduced the expression of fibrotic mediators, such as alpha-smooth muscle actin (alpha-SMA), collagen, and fibronectin 1 in the pancreas and PSCs.	piperine	13-21	fibronectin 1	Mus musculus	139-152
31497235-3	2019	We initially discovered that RSV significantly improved cardiac function and suppressed the expression of fibrosis markers, such as collagen-I, collagen-III, and fibronectin, and pro-inflammatory cytokines, including interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha).	Resveratrol	29-32	fibronectin 1	Mus musculus	162-173
31526499-8	2019	The progression of renal injury in BPs treated mice was inhibited with less expression of type IV collagen (Col IV), fibronectin (FN) and alpha-smooth muscle actin (alpha-SMA).	bps	35-38	fibronectin 1	Mus musculus	117-128
31526499-8	2019	The progression of renal injury in BPs treated mice was inhibited with less expression of type IV collagen (Col IV), fibronectin (FN) and alpha-smooth muscle actin (alpha-SMA).	bps	35-38	fibronectin 1	Mus musculus	130-132
31695328-16	2019	100 mg/kg silibinin markedly reduced collagen I, fibronectin, and p-p65 expressions in mice renal tissues.	Silybin	10-19	fibronectin 1	Mus musculus	49-60
31469894-10	2019	Compared with normal fibroblasts and TGF-beta-induced myofibroblasts, H2O2-induced senescent fibroblasts showed a nonfibrogenic phenotype, including a reduced response to growth factor basic fibroblast growth factor (bFGF) or platelet-derived growth factor-BB (PDGF-BB), increased matrix metalloproteinase (MMP)1/3/13 expression, and decreased fibronectin and collagen I expression.	Hydrogen Peroxide	70-74	fibronectin 1	Mus musculus	344-355
31375695-8	2019	Moreover, upregulation of the Fn1, Mmp2, and Snai1 mRNAs, which are hallmarks of tube-forming growth in PDAC, was demonstrated in a mouse model of carcinogenesis showing rapid progression because of the aggressive invasion of tube-forming cancer.	pdac	104-108	fibronectin 1	Mus musculus	30-33
31308744-0	2019	Silencing of LINC01116 suppresses the development of oral squamous cell carcinoma by up-regulating microRNA-136 to inhibit FN1.	linc01116	13-22	fibronectin 1	Mus musculus	123-126
31308744-6	2019	In addition, the interaction among LINC01116, miR-136, and FN1 was identified.	linc01116	35-44	fibronectin 1	Mus musculus	59-62
31308744-9	2019	LINC01116 could competitively bind to miR-136, which targets and negatively regulates FN1.	linc01116	0-9	fibronectin 1	Mus musculus	86-89
31308744-11	2019	Conclusion: The fundamental findings in this study collectively demonstrate that LINC01116 silencing may inhibit the progression of OSCC via the miR-136-mediated FN1 inhibition, highlighting a promising therapeutic strategy for OSCC treatment.	linc01116	81-90	fibronectin 1	Mus musculus	162-165
31189740-0	2019	microRNA-613 exerts anti-angiogenic effect on nasopharyngeal carcinoma cells through inactivating the AKT signaling pathway by down-regulating FN1.	microrna-613	0-12	fibronectin 1	Mus musculus	143-146
31189740-3	2019	Therefore, the present study probes into the underlying mechanism of miR-613 in NPC via AKT signaling pathway by regulating Fibronectin 1 (FN1).Methods: First, microarray analysis was used to screen differentially expressed genes (DEGs) and regulatory miRs associated with NPC.	mir-613	69-76	fibronectin 1	Mus musculus	124-137
31189740-3	2019	Therefore, the present study probes into the underlying mechanism of miR-613 in NPC via AKT signaling pathway by regulating Fibronectin 1 (FN1).Methods: First, microarray analysis was used to screen differentially expressed genes (DEGs) and regulatory miRs associated with NPC.	mir-613	69-76	fibronectin 1	Mus musculus	139-142
31189740-6	2019	Then, tumorigenesis and MVD were determined after Xenograft in nude mice.Results: FN1 modulated by miR-613 was critical for NPC via the AKT signaling pathway.	mir-613	99-106	fibronectin 1	Mus musculus	82-85
31189740-8	2019	Besides, miR-613 was verified to target FN1.	mir-613	9-16	fibronectin 1	Mus musculus	40-43
31189740-10	2019	Furthermore, cell apoptosis was promoted and tumorigenesis and MVD in nude mice were inhibited with overexpression of miR-613, silenced FN1 or LY294002 treatment.Conclusion: Taken together, miR-613 inhibits angiogenesis in NPC cells through inactivating FN1-dependent AKT signaling pathway.	mir-613	118-125	fibronectin 1	Mus musculus	254-257
31189740-10	2019	Furthermore, cell apoptosis was promoted and tumorigenesis and MVD in nude mice were inhibited with overexpression of miR-613, silenced FN1 or LY294002 treatment.Conclusion: Taken together, miR-613 inhibits angiogenesis in NPC cells through inactivating FN1-dependent AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	fibronectin 1	Mus musculus	254-257
31189740-10	2019	Furthermore, cell apoptosis was promoted and tumorigenesis and MVD in nude mice were inhibited with overexpression of miR-613, silenced FN1 or LY294002 treatment.Conclusion: Taken together, miR-613 inhibits angiogenesis in NPC cells through inactivating FN1-dependent AKT signaling pathway.	mir-613	190-197	fibronectin 1	Mus musculus	136-139
31281949-2	2019	Most recently, experiments involving subcutaneous (s.c.) administration of a PEGylated FUD (PEG-FUD) of 27.5 kDa molecular weight yielded a significant reduction of fibronectin and collagen deposition in a murine model of renal fibrosis.	D-(-)-Fructose	87-90	fibronectin 1	Mus musculus	165-176
31281949-2	2019	Most recently, experiments involving subcutaneous (s.c.) administration of a PEGylated FUD (PEG-FUD) of 27.5 kDa molecular weight yielded a significant reduction of fibronectin and collagen deposition in a murine model of renal fibrosis.	peg-fud	92-99	fibronectin 1	Mus musculus	165-176
31281949-6	2019	Isothermal titration calorimetry (ITC) and confocal fluorescence microscopy experiments verified FUD and PEG-FUD fibronectin binding activity preservation following sulfo-Cy5 labeling.	sulfo-cy5	165-174	fibronectin 1	Mus musculus	113-124
31092012-6	2019	Nicotine infusion significantly induced collagen I, fibronectin, and arterial stiffness in wild-type but not Sirt1 Super mice.	Nicotine	0-8	fibronectin 1	Mus musculus	52-63
30662363-6	2019	Clopidogrel, administered during the last three months, significantly decreased blood glucose, collagen and fibronectin expression compared to vehicle-treated diabetic mice.	Clopidogrel	0-11	fibronectin 1	Mus musculus	108-119
30951378-7	2019	Moreover, delayed administration of MC1568 at 3 d after ureteral obstruction reversed the expression of alpha-SMA, fibronectin, and collagen 1 and increased expression of matrix metalloproteinase (MMP)-2 and -9.	MC1568	36-42	fibronectin 1	Mus musculus	115-126
31934031-0	2019	Recombinant C-terminal heparin-binding domain of fibronectin polypeptide protects against liver damage, reduces serum inflammatory cytokines, and decreases mortality in acute liver failure.	Carbon	12-13	fibronectin 1	Mus musculus	49-60
31934031-1	2019	This study aimed to evaluate the effect of recombinant C-terminal heparin-binding domain of fibronectin (FNCHBD) polypeptide on live-damage protection, inflammation, and mortality in acute liver failure (ALF) mice.	Carbon	55-56	fibronectin 1	Mus musculus	92-103
30317629-6	2019	LncRNA 74.1 promoted reactive oxygen species defense by activating prosurvival autophagy then decreased ECM-related proteins fibronectin and collagen I involved in renal fibrosis.	reactive	21-29	fibronectin 1	Mus musculus	125-136
30317629-6	2019	LncRNA 74.1 promoted reactive oxygen species defense by activating prosurvival autophagy then decreased ECM-related proteins fibronectin and collagen I involved in renal fibrosis.	oxygen species	30-44	fibronectin 1	Mus musculus	125-136
30894457-7	2019	Inflammatory MCP-1 and fibrosis (collagen, fibronectin, plasminogen activator inhibitor-1, and osteopontin) renal biomarkers were significantly reduced in the CXA-10 (2.5 mpk) group.	10-nitro-oleic acid	159-165	fibronectin 1	Mus musculus	43-54
30938983-0	2019	Extradomain-B Fibronectin-Targeted Dextran-Based Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Probe for Detecting Pancreatic Cancer.	Dextrans	35-42	fibronectin 1	Mus musculus	14-25
30938983-1	2019	A dextran-peptide conjugate was developed for magnetic resonance (MR) molecular imaging of pancreatic ductal adenocarcinoma (PDAC) through its overexpressed microenvironment biomarker, extradomain-B fibronectin (EDB-FN).	dextran-peptide	2-17	fibronectin 1	Mus musculus	199-210
30925687-4	2019	Treatment with garcinol also decreased mRNA levels of transforming growth factor-beta, matrix metalloproteinase (MMP)-2, MMP-9, and fibronectin.	garcinol	15-23	fibronectin 1	Mus musculus	132-143
31049028-5	2019	Here, we found that BLM-induced lung fibrosis with thickened interstitial lung tissue, including fibronectin and collagen, was correlated with the increased serum concentrations of IL-6 and IL-33 and accompanied by reduced lung function, including FRC (functional residual capacity), C chord (lung compliance), IC (inspiratory capacity), VC (vital capacity), TLC (total lung capacity), and FVC (forced vital capacity) (p &lt; 0.05).	Bleomycin	20-23	fibronectin 1	Mus musculus	97-108
30915776-8	2019	MiR-34b-5p knockdown in vivo attenuated the bleomycin-induced pulmonary fibrosis in wild-type mice, displayed by a reduced expression of Col1A1, fibronectin (Fn), and alpha-SMA.	Bleomycin	44-53	fibronectin 1	Mus musculus	145-156
30915776-8	2019	MiR-34b-5p knockdown in vivo attenuated the bleomycin-induced pulmonary fibrosis in wild-type mice, displayed by a reduced expression of Col1A1, fibronectin (Fn), and alpha-SMA.	Bleomycin	44-53	fibronectin 1	Mus musculus	158-160
30592280-9	2019	In conclusion, aldosterone significantly inhibited H3K9 acetylation by upregulating HDAC1 protein expression levels in the renal distal convoluted tubule cells, resulting in its inability to bind to the KL promoter, loss of transcription of the KL gene and increased expression of the renal fibrosis gene, Fn1.	Aldosterone	15-26	fibronectin 1	Mus musculus	306-309
30609243-3	2019	Thus, here, a novel process is presented to functionalize PLLA surfaces with poly(ethyl acrylate) (PEA) brushes to provide biological functionality through PEA"s ability to induce spontaneous organization of the extracellular matrix component fibronectin (FN) into physiological-like nanofibrils.	poly(ethylacrylate)	77-97	fibronectin 1	Mus musculus	243-254
30609243-3	2019	Thus, here, a novel process is presented to functionalize PLLA surfaces with poly(ethyl acrylate) (PEA) brushes to provide biological functionality through PEA"s ability to induce spontaneous organization of the extracellular matrix component fibronectin (FN) into physiological-like nanofibrils.	poly(ethylacrylate)	77-97	fibronectin 1	Mus musculus	256-258
30609243-3	2019	Thus, here, a novel process is presented to functionalize PLLA surfaces with poly(ethyl acrylate) (PEA) brushes to provide biological functionality through PEA"s ability to induce spontaneous organization of the extracellular matrix component fibronectin (FN) into physiological-like nanofibrils.	poly(ethylacrylate)	99-102	fibronectin 1	Mus musculus	243-254
30609243-3	2019	Thus, here, a novel process is presented to functionalize PLLA surfaces with poly(ethyl acrylate) (PEA) brushes to provide biological functionality through PEA"s ability to induce spontaneous organization of the extracellular matrix component fibronectin (FN) into physiological-like nanofibrils.	poly(ethylacrylate)	99-102	fibronectin 1	Mus musculus	256-258
30609243-7	2019	PEA brushes trigger FN organization into nanofibrils, which retain their ability to enhance adhesion and differentiation of C2C12 cells.	poly(ethylacrylate)	0-3	fibronectin 1	Mus musculus	20-22
30708951-6	2019	Cirsiliol was found to be effective in restraining the colony formation and migration of fibronectin-induced B16F10 metastatic melanoma cells.	cirsiliol	0-9	fibronectin 1	Mus musculus	89-100
30401638-10	2019	Liver mRNA expression of Col1a1, Col1a2, Col3a1, fibronectin (Fn1), vimentin (Vim) and fibroblast-specific protein 1 (FSP1) were all increased in DB-treated mice.	diosbulbin B	146-148	fibronectin 1	Mus musculus	49-60
30401638-10	2019	Liver mRNA expression of Col1a1, Col1a2, Col3a1, fibronectin (Fn1), vimentin (Vim) and fibroblast-specific protein 1 (FSP1) were all increased in DB-treated mice.	diosbulbin B	146-148	fibronectin 1	Mus musculus	62-65
30358439-10	2019	Furthermore, NCC170 treatment significantly decreased fibrosis measured by Ashcroft score as well as expression of type 1 collagen and fibronectin in bleomycin-treated mouse lungs.	Bleomycin	150-159	fibronectin 1	Mus musculus	135-146
30596336-0	2019	Downregulation of NEAT1 reverses the radioactive iodine resistance of papillary thyroid carcinoma cell via miR-101-3p/FN1/PI3K-AKT signaling pathway.	radioactive iodine	37-55	fibronectin 1	Mus musculus	118-121
30596336-6	2019	MTT assay and flow cytometry assay were performed to observe the impact of NEAT1/miR-101-3p/FN1 on cell viability and apoptosis in radioactivity iodine (RAI)-resistant PTC cell lines, respectively.	Insulin, Short-Acting	153-156	fibronectin 1	Mus musculus	92-95
30596336-12	2019	The expression of FN1, an overexpressed downstream protein in RAI-resistance PTC tissues, could be tuned down by miR-101-3p, while the decrease could be restored by NEAT1.	Insulin, Short-Acting	62-65	fibronectin 1	Mus musculus	18-21
30596336-12	2019	The expression of FN1, an overexpressed downstream protein in RAI-resistance PTC tissues, could be tuned down by miR-101-3p, while the decrease could be restored by NEAT1.	mir-101-3p	113-123	fibronectin 1	Mus musculus	18-21
30951378-3	2019	Administration of MC1568 immediately after UUO injury reduced expression of alpha-smooth muscle actin (alpha-SMA), fibronectin, and collagen 1.	MC1568	18-24	fibronectin 1	Mus musculus	115-126
31235855-3	2019	Our study analyzed the mechanism of action of low-diluted Phenacetinum on murine cutaneous melanoma process in a fibronectin matrix environment.	Phenacetin	58-70	fibronectin 1	Mus musculus	113-124
31013842-13	2019	In addition, RSV decreased the protein expression of PCNA, fibronectin, and upregulated the ratio of Bax (Bcl-2-associated X) and Bcl-2 (B-cell lymphoma/leukemia 2) in vivo.	Resveratrol	13-16	fibronectin 1	Mus musculus	59-70
31275884-9	2019	The expression of fibronectin mRNA is also returned to control levels with the 500 nM dose of ET-traps.	et-traps	94-102	fibronectin 1	Mus musculus	18-29
30816496-9	2019	The levels of collagen I, fibronectin and alpha-smooth muscle actin were increased by UUO in mice or by transforming growth factor (TGF)-beta1 treatment in NRK-52E cells, and were reduced by ASX administration.	astaxanthine	191-194	fibronectin 1	Mus musculus	26-37
30776489-5	2019	We have shown that PCLS during in vitro incubation retain characteristics of bleomycin model with increased expression of fibrosis related genes ACTA2 (alpha-smooth muscle actin), COL1A1 (collagen 1), FN1 (fibronectin 1), MMP12 (matrix metalloproteinase 12) and TIMP1 (tissue inhibitor of metalloproteinases).	Bleomycin	77-86	fibronectin 1	Mus musculus	201-204
30918879-10	2019	Analysis of tumor tissue transcriptomes showed that the expression of genes related to the inflammatory response including CL and XCL genes increased, while that of Fn1 decreased in the cisplatin+PDT group compared with the PDT group.	Cisplatin	186-195	fibronectin 1	Mus musculus	165-168
30840958-9	2019	RESULTS: In FSGS mouse models, SAL treatment could ameliorate proteinuria, renal function, and markers of Nephrotic Syndrome inhibit alpha-smooth muscle actin and fibronectin expression and downregulates the expression of HIF-1alpha.	rhodioloside	31-34	fibronectin 1	Mus musculus	163-174
31553994-4	2019	SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species.	sodium arsenite	0-2	fibronectin 1	Mus musculus	66-77
31553994-4	2019	SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species.	sodium arsenite	0-2	fibronectin 1	Mus musculus	79-81
31553994-6	2019	The administration of SA (IP) suppressed BLM-induced lung fibrosis characterized as the inhibition of collagen deposition, TGF-beta accumulation in bronchoalveolar lavage fluid, and the expression of FN and collagen 1a2 in lung tissue.	sodium arsenite	22-24	fibronectin 1	Mus musculus	200-202
31553994-6	2019	The administration of SA (IP) suppressed BLM-induced lung fibrosis characterized as the inhibition of collagen deposition, TGF-beta accumulation in bronchoalveolar lavage fluid, and the expression of FN and collagen 1a2 in lung tissue.	Bleomycin	41-44	fibronectin 1	Mus musculus	200-202
30219058-8	2018	RESULTS: Low muM concentrations of Nintedanib (1 muM) and mM concentrations of Pirfenidone (2.5 mM) reduced fibrotic gene expression including Collagen 1a1 and Fibronectin in murine and human 3D-LTCs as well as pmATII cells.	nintedanib	35-45	fibronectin 1	Mus musculus	160-171
29729197-6	2018	Importantly, administration of the pharmacological plasmin inhibitor tranexamic acid or genetic reduction of plasminogen, the circulating zymogen of plasmin, ameliorates APAP-induced hepatic fibronectin degradation and sinusoidal bleeding.	Tranexamic Acid	69-84	fibronectin 1	Mus musculus	191-202
29729197-6	2018	Importantly, administration of the pharmacological plasmin inhibitor tranexamic acid or genetic reduction of plasminogen, the circulating zymogen of plasmin, ameliorates APAP-induced hepatic fibronectin degradation and sinusoidal bleeding.	Acetaminophen	170-174	fibronectin 1	Mus musculus	191-202
30268856-7	2018	Moreover, celastrol reduced the renal mRNA expression levels of tumor necrosis factor-alpha, interleukin-1beta, P2RX7, F4/80, CD68, transforming growth factor-beta, collagen-1, and fibronectin, which were high in the Pkd1 miR TG mice.	celastrol	10-19	fibronectin 1	Mus musculus	181-192
29975570-7	2019	In addition, inhibition of Gal-1 by OTX-008 showed significant decrease in p-Akt/AP4 and protein-promoter activity of Gal-1 and fibronectin.	compound 0118	36-43	fibronectin 1	Mus musculus	128-139
30268666-0	2018	Astaxanthin ameliorates experimental diabetes-induced renal oxidative stress and fibronectin by upregulating connexin43 in glomerular mesangial cells and diabetic mice.	astaxanthine	0-11	fibronectin 1	Mus musculus	81-92
30268666-3	2018	The current study aimed to investigate whether astaxanthin (AST) could ameliorate the pathological progression of DN by upregulating Cx43 and activating the Nrf2/ARE signaling, which is a pivotal anti-oxidative stress system, to strengthen the cellular anti-oxidative capacity and diminish fibronectin (FN) accumulation in HG-induced glomerular mesangial cells (GMCs).	astaxanthine	47-58	fibronectin 1	Mus musculus	290-301
30268666-3	2018	The current study aimed to investigate whether astaxanthin (AST) could ameliorate the pathological progression of DN by upregulating Cx43 and activating the Nrf2/ARE signaling, which is a pivotal anti-oxidative stress system, to strengthen the cellular anti-oxidative capacity and diminish fibronectin (FN) accumulation in HG-induced glomerular mesangial cells (GMCs).	astaxanthine	47-58	fibronectin 1	Mus musculus	303-305
29746885-6	2018	In mouse primary HSCs, curcumin prevented succinate- and CoCl2-induced hypoxia-inducible transcription factor-1alpha (HIF-1alpha) induction via suppression of ROS production and effectively reduced gene expressions of Col1alpha, Col3alpha, fibronectin and TGF-beta1 with inflammation inhibition.	Curcumin	23-31	fibronectin 1	Mus musculus	240-251
29746885-6	2018	In mouse primary HSCs, curcumin prevented succinate- and CoCl2-induced hypoxia-inducible transcription factor-1alpha (HIF-1alpha) induction via suppression of ROS production and effectively reduced gene expressions of Col1alpha, Col3alpha, fibronectin and TGF-beta1 with inflammation inhibition.	Succinic Acid	42-51	fibronectin 1	Mus musculus	240-251
29746885-6	2018	In mouse primary HSCs, curcumin prevented succinate- and CoCl2-induced hypoxia-inducible transcription factor-1alpha (HIF-1alpha) induction via suppression of ROS production and effectively reduced gene expressions of Col1alpha, Col3alpha, fibronectin and TGF-beta1 with inflammation inhibition.	cobaltous chloride	57-62	fibronectin 1	Mus musculus	240-251
30424556-7	2018	Additionally, the expression of nicotinamide adenine dinucleotide phosphate oxidase 4, 8-hydroxy-2"-deoxyguanosine, 3-nitrotyrosine, collagen IV, and fibronectin was decreased, while the expression of endothelial nitric oxide synthase and superoxide dismutase 2 was increased by resveratrol treatment.	Resveratrol	279-290	fibronectin 1	Mus musculus	150-161
30356276-8	2018	In vivo, PEG-FUD significantly decreased fibronectin by ~70% in UUO kidneys as determined by both IHC and immunoblotting, respectively.	peg-fud	9-16	fibronectin 1	Mus musculus	41-52
30356276-11	2018	Immunoblotting studies also showed that the fibronectin remaining after PEG-FUD treatment was intact.	peg-fud	72-79	fibronectin 1	Mus musculus	44-55
30356276-16	2018	We propose that PEG-FUD, a specific inhibitor of fibronectin assembly, may be a candidate therapeutic for the treatment of fibrosis in kidney diseases.	peg-fud	16-23	fibronectin 1	Mus musculus	49-60
30257681-9	2018	rIL-32gamma inhibited the production of fibronectin and alpha-SMA in MRC-5 cells stimulated with TGF-beta.	ril-32gamma	0-11	fibronectin 1	Mus musculus	40-51
30219058-8	2018	RESULTS: Low muM concentrations of Nintedanib (1 muM) and mM concentrations of Pirfenidone (2.5 mM) reduced fibrotic gene expression including Collagen 1a1 and Fibronectin in murine and human 3D-LTCs as well as pmATII cells.	pirfenidone	79-90	fibronectin 1	Mus musculus	160-171
29722566-4	2018	Posttreatment with GW5074 reduced fibronectin (FN) expression, collagen deposition, and inflammatory cell infiltration in bleomycin-challenged mice, suggesting an antifibrotic property of GW5074.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	19-25	fibronectin 1	Mus musculus	34-45
29380373-10	2018	Folic acid induced nephropathy was associated with the overexpression of inflammatory markers MCP-1, F4/80, type IV collagen, fibronectin and TGF-beta1 compared to control groups, which were partially attenuated by metformin treatment.	Folic Acid	0-10	fibronectin 1	Mus musculus	126-137
29380373-10	2018	Folic acid induced nephropathy was associated with the overexpression of inflammatory markers MCP-1, F4/80, type IV collagen, fibronectin and TGF-beta1 compared to control groups, which were partially attenuated by metformin treatment.	Metformin	215-224	fibronectin 1	Mus musculus	126-137
29722566-4	2018	Posttreatment with GW5074 reduced fibronectin (FN) expression, collagen deposition, and inflammatory cell infiltration in bleomycin-challenged mice, suggesting an antifibrotic property of GW5074.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	19-25	fibronectin 1	Mus musculus	47-49
30065303-9	2018	Surface plasmon resonance assay demonstrated that CSGal-1 interacted with alpha5beta1integrin and fibronectin in a glycan-dependent manner.	Polysaccharides	115-121	fibronectin 1	Mus musculus	98-109
29944334-4	2018	The behavior of balancing bacterial inhibition and cell attraction of the PEGMA500-Phosmer coating was explained by the grafted phosphate groups, with an appropriate PEG brush length facilitating greater levels of calcium deposition and further fibronectin adsorption when compared with that of the raw Ti alloy surface.	Polyethylene Glycols	74-77	fibronectin 1	Mus musculus	245-256
29963235-2	2018	We aimed to establish molecular imaging during treatment with sunitinib using the fibronectin extradomain A specific small immunoprotein(SIP)-F8 in glioma.	Sunitinib	62-71	fibronectin 1	Mus musculus	82-93
29973247-16	2018	The adoptive transfer of cytokine-induced MDSCs into STZ-induced mice normalized the glomerular filtration rate to reduce the kidney to body weight ratio and decrease fibronectin production in the renal glomerulus, ameliorating renal fibrosis.	Streptozocin	53-56	fibronectin 1	Mus musculus	167-178
29808285-11	2018	Most interestingly, ECM/stromal components, fibronectin and laminin-332, as well as the carcinogenic beta-catenin pathway, are remarkably reduced by galunisertib-treated Abcb5ko mice.	LY-2157299	149-161	fibronectin 1	Mus musculus	44-55
29963130-8	2018	Expression levels of migration-associated proteins including vimentin, fibronectin and epithelial cadherin were regulated by camptothecin treatment in NPC cells.	Camptothecin	125-137	fibronectin 1	Mus musculus	71-82
30008599-6	2018	High-dose morphine-induced Cx43 increased the expression levels of focal adhesion molecules, namely fibronectin and alpha-smooth muscle actin (alpha-SMA) through the activation of transforming growth factor (TGF)-beta1 signaling.	Morphine	10-18	fibronectin 1	Mus musculus	100-111
29505886-4	2018	Moreover, OAA treatment significantly decreased the elevations of IL-1beta, IL-6, TNF-alpha, TGF-beta1, and fibronectin, and the activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the lungs of PHMG-P-treated mice.	Oxaloacetic Acid	10-13	fibronectin 1	Mus musculus	108-119
29704504-3	2018	Rapamycin suppressed the down-regulation of E-cadherin and up-regulation of fibronectin in bleomycin-induced pulmonary fibrosis mice.	Bleomycin	91-100	fibronectin 1	Mus musculus	76-87
29849933-7	2018	Strikingly, after three weeks treatment with rotenone, we found that the unilateral I/R-induced tubular damage, tubulointerstitial fibrosis were all attenuated by rotenone as determined by the tubular injury score, Masson staining, and the levels of collagen-I, collagen-III, fibronectin, PAI-1, and TGF-beta.	Rotenone	45-53	fibronectin 1	Mus musculus	276-287
29800294-4	2018	To investigate this question, we cultured murine primary bone marrow-derived macrophages (BMMs) and RAW264.7 cells on fibronectin-coated polyacrylamide (PA) gels of defined stiffnesses (1, 20 and 150 kPa) that approximate the physical properties of physiologic tissues.	polyacrylamide	137-151	fibronectin 1	Mus musculus	118-129
29849933-7	2018	Strikingly, after three weeks treatment with rotenone, we found that the unilateral I/R-induced tubular damage, tubulointerstitial fibrosis were all attenuated by rotenone as determined by the tubular injury score, Masson staining, and the levels of collagen-I, collagen-III, fibronectin, PAI-1, and TGF-beta.	Rotenone	163-171	fibronectin 1	Mus musculus	276-287
29801150-5	2018	Methods: Mouse TM (MTM) cells were isolated from B6;129S1-Bambitm1Jian/J flox mice, characterized for TGFbeta2 and dexamethasone (DEX)-induced expression of fibronectin, collagen-1, collagen-4, laminin, alpha-smooth muscle actin, cross-linked actin networks (CLANs) formation, and DEX-induced myocilin (MYOC) expression.	Dexamethasone	115-128	fibronectin 1	Mus musculus	157-168
29725474-6	2018	The epithelial-mesenchymal transition (EMT) markers, vimentin and fibronectin, were downregulated following TBG treatment.	telocinobufagin	108-111	fibronectin 1	Mus musculus	66-77
30023888-5	2018	Moreover, arginine-modified films exhibited a nearly equivalent cell viability compared to the films modified with the natural extracellular matrix component fibronectin.	Arginine	10-18	fibronectin 1	Mus musculus	158-169
29609658-13	2018	BLM induced fibrosis in mouse lungs that was also attenuated by SFN treatment, and SFN treatment decreased BLM-induced fibronectin expression, TGF-beta1 expression, and the levels of collagen I in the lungs of mice.	sulforaphane	83-86	fibronectin 1	Mus musculus	119-130
29801150-5	2018	Methods: Mouse TM (MTM) cells were isolated from B6;129S1-Bambitm1Jian/J flox mice, characterized for TGFbeta2 and dexamethasone (DEX)-induced expression of fibronectin, collagen-1, collagen-4, laminin, alpha-smooth muscle actin, cross-linked actin networks (CLANs) formation, and DEX-induced myocilin (MYOC) expression.	Dexamethasone	130-133	fibronectin 1	Mus musculus	157-168
29365185-1	2018	Objectives: We have previously reported that F8-IL4, a fusion protein consisting of the F8 antibody specific to the alternatively-spliced extra domain A of fibronectin and of murine IL-4, cures mice with established arthritis, when used in combination with dexamethasone (DXM).	Dexamethasone	257-270	fibronectin 1	Mus musculus	156-167
29847662-10	2018	Analysis of fibronectin expression in TM1 cells after treatment with 10 muM latanoprost acid showed a statistically significant increase in expression; this increase was abrogated by cotreatment with a siRNA for FOXC1.	Latanoprost	76-92	fibronectin 1	Mus musculus	12-23
29365185-1	2018	Objectives: We have previously reported that F8-IL4, a fusion protein consisting of the F8 antibody specific to the alternatively-spliced extra domain A of fibronectin and of murine IL-4, cures mice with established arthritis, when used in combination with dexamethasone (DXM).	Dexamethasone	272-275	fibronectin 1	Mus musculus	156-167
29599817-8	2018	The mRNA expression levels of GSK3beta and DKK1 in the WYHZTL formula and XAV-939-treated group were significantly higher than those in the BLM group, while Wnt1, beta-catenin, TCF4, cyclin D1, survivin, VEGF, CTGF, FN1, collagen I/III were decreased.	XAV939	74-81	fibronectin 1	Mus musculus	216-219
29531814-7	2018	Herein, we demonstrate that 2-AP can restore E-cadherin expression and inhibit fibronectin and vimentin expression in TGF-beta1-treated A549 lung cancer cells.	2-Aminopurine	28-32	fibronectin 1	Mus musculus	79-90
29070573-10	2018	Through the identification of putative target genes of these three miRNAs, mRNA and protein expression of the Ca2+/calmodulin-dependent protein kinase type II beta-chain ( Camk2b) gene (a target gene of miR-34c-5p) were found to be increased significantly in aldosterone-treated cells, where fibronectin (FN) and alpha-smooth muscle actin were induced.	Aldosterone	259-270	fibronectin 1	Mus musculus	292-303
29070573-10	2018	Through the identification of putative target genes of these three miRNAs, mRNA and protein expression of the Ca2+/calmodulin-dependent protein kinase type II beta-chain ( Camk2b) gene (a target gene of miR-34c-5p) were found to be increased significantly in aldosterone-treated cells, where fibronectin (FN) and alpha-smooth muscle actin were induced.	Aldosterone	259-270	fibronectin 1	Mus musculus	305-307
29414645-7	2018	Moreover, Oroxylin A treatment remarkably inhibited extracellular matrix (ECM) deposition, and significantly down-regulated the mRNA and protein expression of liver fibrosis markers including alpha1(I)collagen, fibronectin, alpha-smooth muscle actin (alpha-SMA), PDGF-betaR, and TGF-betaR1 in CCl4-induced murine model of liver fibrosis.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	10-20	fibronectin 1	Mus musculus	211-222
29414645-8	2018	Furthermore, experimental results in vitro showed that Oroxylin A treatment reduced the mRNA and protein expression of HSC activation markers, alpha-SMA, desmin, alpha1 (I) collagen, fibronectin, TGF-beta, and TNF-alpha, in a dose dependent manner.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	55-65	fibronectin 1	Mus musculus	183-194
29488175-8	2018	Eng+/- mice subjected to bleomycin challenge show a marked decrease in dermal thickness (P &lt; 0.005) and reduced collagen content and decreased collagen I, fibronectin, alpha-smooth muscle actin levels as compared to Eng+/+ mice, both under basal and bleomycin treated conditions.	Bleomycin	25-34	fibronectin 1	Mus musculus	158-169
29367111-6	2018	Moreover, zingerone attenuated the pathological injuries of kidneys, reduced the surface area of Bowman"s capsule, Bowman"s space, glomerular tuft, and decreased the expression of collagen IV and fibronectin in kidneys in db/db mice.	zingerone	10-19	fibronectin 1	Mus musculus	196-207
29382667-2	2018	The fibronectin receptor alpha5 subunit is proinflammatory through binding to and activating phosphodiesterase 4D5, which inhibits anti-inflammatory cyclic adenosine monophosphate and protein kinase A.	Cyclic AMP	149-179	fibronectin 1	Mus musculus	4-15
29096132-7	2017	In patch-clamp recordings, fibronectin significantly inhibited GABA current, while RGD, which is known to disrupt fibronectin-integrin-dependent cell adhesive events, strikingly enhanced GABA tonic currents in DGGCs in hippocampal slices.	gamma-Aminobutyric Acid	63-67	fibronectin 1	Mus musculus	27-38
29263369-0	2017	Modulation of fibronectin and laminin expression by Rhodium (II) citrate-coated maghemite nanoparticles in mice bearing breast tumor.	(ii) citrate	60-72	fibronectin 1	Mus musculus	14-25
29263369-0	2017	Modulation of fibronectin and laminin expression by Rhodium (II) citrate-coated maghemite nanoparticles in mice bearing breast tumor.	ferric oxide	80-89	fibronectin 1	Mus musculus	14-25
29263369-9	2017	We witnessed statistically significant reductions of FN and LN expression following treatment with Magh-Rh2(H2cit)4.	magh-rh2	99-107	fibronectin 1	Mus musculus	53-55
29263369-9	2017	We witnessed statistically significant reductions of FN and LN expression following treatment with Magh-Rh2(H2cit)4.	h2cit	108-113	fibronectin 1	Mus musculus	53-55
29263369-10	2017	We have demonstrated that the antitumor effects of Magh-Rh2(H2cit)4 and Rh2(H2cit)4 regulate the expression of FN and LN in metastatic breast tumors.	magh-rh2	51-59	fibronectin 1	Mus musculus	111-113
29263369-10	2017	We have demonstrated that the antitumor effects of Magh-Rh2(H2cit)4 and Rh2(H2cit)4 regulate the expression of FN and LN in metastatic breast tumors.	h2cit	60-65	fibronectin 1	Mus musculus	111-113
29263369-10	2017	We have demonstrated that the antitumor effects of Magh-Rh2(H2cit)4 and Rh2(H2cit)4 regulate the expression of FN and LN in metastatic breast tumors.	rh2	56-59	fibronectin 1	Mus musculus	111-113
29263369-10	2017	We have demonstrated that the antitumor effects of Magh-Rh2(H2cit)4 and Rh2(H2cit)4 regulate the expression of FN and LN in metastatic breast tumors.	h2cit	76-81	fibronectin 1	Mus musculus	111-113
29301371-6	2018	Treatment with dapagliflozin prevented podocyte injury, glomerular pathology and renal fibrosis determined by second harmonic generation (SHG), nephrin, synaptopodin, collagen IV, and fibronectin immunofluorescence microscopy.	dapagliflozin	15-28	fibronectin 1	Mus musculus	184-195
29133357-8	2018	MDSCs also prevented the CsA-induced increase in fibronectin in microvascular and glomerular endothelial cells.	Cyclosporine	25-28	fibronectin 1	Mus musculus	49-60
29346804-11	2018	Parallel experiments in 3D-HTM showed that trabodenoson treatment significantly increased MMP-2 activity and MMP-14 abundance, while decreasing fibronectin and collagen IV expression.	trabodenoson	43-55	fibronectin 1	Mus musculus	144-155
28976766-0	2017	Synthesis and Assessment of Peptide Gd-DOTA Conjugates Targeting Extradomain B Fibronectin for Magnetic Resonance Molecular Imaging of Prostate Cancer.	gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate	36-43	fibronectin 1	Mus musculus	79-90
29184125-4	2017	We analyzed these cellular responses on fibronectin-coated polyacrylamide hydrogels prepared at a physiologic range of ECM stiffness and found that stiffening of the ECM leads to both cell cycling and cell motility in serum-stimulated primary mouse dermal fibroblasts.	polyacrylamide	59-73	fibronectin 1	Mus musculus	40-51
28894214-6	2017	Sul-121 prevented progression of albuminuria and attenuated kidney damage in db/db, as evidenced by lower glomerular fibronectin expression (~50%), decreased focal glomerular sclerosis score (~40%) and normalization of glomerular size and kidney weight.	Sul-121	0-7	fibronectin 1	Mus musculus	117-128
29101337-6	2017	Under the conditions, administration of TSA significantly decreased TGF-beta1-stimulated expression of alpha-SMA, fibronectin, phospho-JNK, and cleaved Notch-2; however, the levels of phospho-Smad2/3, phospho-p38 and phospho-ERK remained unchanged.	trichostatin A	40-43	fibronectin 1	Mus musculus	114-125
28827139-4	2017	Our data indicate a dramatic increase of pro-EMT markers, such as type I collagen, alpha-smooth muscle actin, vimentin, and fibronectin, under conditions of lens GSH depletion.	Glutathione	162-165	fibronectin 1	Mus musculus	124-135
33445303-3	2017	Extracellular matrix (ECM) proteins, vitronectin and fibronectin, displayed enhanced adsorption to the scaffolds compared to the silicon controls.	Silicon	129-136	fibronectin 1	Mus musculus	53-64
29042968-5	2017	The results demonstrated that HES reduced obstruction-induced renal injury and deposition of the extracellular matrix components collagen-I and fibronectin in UUO mouse kidneys (P&lt;0.05).	hesperetin	30-33	fibronectin 1	Mus musculus	144-155
28947734-2	2017	A peptide-targeted tri-gadolinium nitride metallofullerene, ZD2-Gd3N@C80, is synthesised for sensitive molecular magnetic resonance imaging of extradomain-B fibronectin in aggressive tumours.	tri-gadolinium nitride metallofullerene	19-58	fibronectin 1	Mus musculus	157-168
28762141-0	2017	Anti-fibronectin aptamers improve the colonization of chitosan films modified with D-(+) Raffinose by murine osteoblastic cells.	Raffinose	83-98	fibronectin 1	Mus musculus	5-16
28234642-3	2017	In this study, nanohydroxyapatite (nHA) was incorporated in electrospun nanofibrous polycaprolactone (PCL) scaffolds coated with fibronectin (Fn).	nanohydroxyapatite	15-33	fibronectin 1	Mus musculus	129-140
28234642-3	2017	In this study, nanohydroxyapatite (nHA) was incorporated in electrospun nanofibrous polycaprolactone (PCL) scaffolds coated with fibronectin (Fn).	nanohydroxyapatite	15-33	fibronectin 1	Mus musculus	142-144
28234642-3	2017	In this study, nanohydroxyapatite (nHA) was incorporated in electrospun nanofibrous polycaprolactone (PCL) scaffolds coated with fibronectin (Fn).	nha	35-38	fibronectin 1	Mus musculus	129-140
28234642-3	2017	In this study, nanohydroxyapatite (nHA) was incorporated in electrospun nanofibrous polycaprolactone (PCL) scaffolds coated with fibronectin (Fn).	nha	35-38	fibronectin 1	Mus musculus	142-144
28234642-6	2017	The synergistic effect of Fn and nHA on the both in vitro and in vivo increase of calcium deposition was assessed by biochemical analysis.	Calcium	82-89	fibronectin 1	Mus musculus	26-28
28660304-9	2017	In WT, zaprinast and the combination of zaprinast and serelaxin significantly reduced renal interstitial fibrosis assessed by alpha-SMA, fibronectin, collagen1A1, and gelatinases (MMP2 and MMP9).	zaprinast	7-16	fibronectin 1	Mus musculus	137-148
28660304-9	2017	In WT, zaprinast and the combination of zaprinast and serelaxin significantly reduced renal interstitial fibrosis assessed by alpha-SMA, fibronectin, collagen1A1, and gelatinases (MMP2 and MMP9).	zaprinast	40-49	fibronectin 1	Mus musculus	137-148
28660304-9	2017	In WT, zaprinast and the combination of zaprinast and serelaxin significantly reduced renal interstitial fibrosis assessed by alpha-SMA, fibronectin, collagen1A1, and gelatinases (MMP2 and MMP9).	serelaxin protein, human	54-63	fibronectin 1	Mus musculus	137-148
28660304-10	2017	Intriguingly in cGKI-KO, mRNA and protein expression of fibronectin and collagen1A1 were reduced by zaprinast, in contrast to serelaxin.	zaprinast	100-109	fibronectin 1	Mus musculus	56-67
28648739-8	2017	Furthermore, the severity of DSS-induced colitis was significantly reduced by daily injections of pamoic acid via upregulation of fibronectin and integrin alpha5 in the colonic epithelium.	dss	29-32	fibronectin 1	Mus musculus	130-141
28648739-8	2017	Furthermore, the severity of DSS-induced colitis was significantly reduced by daily injections of pamoic acid via upregulation of fibronectin and integrin alpha5 in the colonic epithelium.	pamoic acid	98-109	fibronectin 1	Mus musculus	130-141
28855534-4	2017	Immunofluorescence staining of tumor slices demonstrated that oral celecoxib treatment at a dose of 200 mg/kg for two weeks successfully normalized the tumor microenvironment, including tumor-associated fibroblast reduction, fibronectin bundle disruption, tumor vessel normalization, and tumor perfusion improvement.	Celecoxib	67-76	fibronectin 1	Mus musculus	225-236
28819200-8	2017	Fibronectin and type I collagen mRNA and protein expressions increased significantly in the kidneys of diabetic mice: PA administration abrogated these increases significantly.	Protactinium	118-120	fibronectin 1	Mus musculus	0-11
29108256-1	2017	Activation of sphingosine kinase 1 (SphK1) signaling pathway mediates fibronectin (FN) upregulation in glomerular mesangial cells (GMCs) under high glucose (HG) condition.	Glucose	148-155	fibronectin 1	Mus musculus	70-81
28767064-5	2017	PCS extract significantly reduced fibrosis in the kidney tissue of diabetic mice as evidenced by decreased mRNA expression of collagen type IV-alpha2, fibronectin, PAI-1, and TGF-beta1.	pcs	0-3	fibronectin 1	Mus musculus	151-162
28824431-12	2017	Furthermore, dibutyltins dichloride, dilaurate, and maleate inhibited the expression of proinflammatory genes in 3T3-L1 cells, such as Vcam1, Dcn, Fn1, S100a8, and Lgals9.	dibutyldichlorotin	13-35	fibronectin 1	Mus musculus	147-150
28824431-12	2017	Furthermore, dibutyltins dichloride, dilaurate, and maleate inhibited the expression of proinflammatory genes in 3T3-L1 cells, such as Vcam1, Dcn, Fn1, S100a8, and Lgals9.	dilaurate	37-46	fibronectin 1	Mus musculus	147-150
28824431-12	2017	Furthermore, dibutyltins dichloride, dilaurate, and maleate inhibited the expression of proinflammatory genes in 3T3-L1 cells, such as Vcam1, Dcn, Fn1, S100a8, and Lgals9.	maleic acid	52-59	fibronectin 1	Mus musculus	147-150
28192862-15	2017	In contrast, histological analyses provided evidence that quercetin feeding was associated with decreased fibronectin and indirect damage indices (Haematoxylin and Eosin) compared with untreated mdx mice.	Quercetin	58-67	fibronectin 1	Mus musculus	106-117
28726774-6	2017	IL-22 could also markedly reduce high glucose-induced and TGF-beta1-induced overexpression of fibronectin and collagen IV in mouse renal glomerular mesangial cells in a dose-dependent manner, suggesting the potential role of IL-22 to inhibit the overproduction of ECM in vitro.	Glucose	38-45	fibronectin 1	Mus musculus	94-105
27459313-7	2017	Treatment with SB-657510 can block UII-induced downregulation of LC3-II and upregulation of p62 while inhibiting UII-induced upregulation of fibronectin and collagen IV.	SB 657510	15-24	fibronectin 1	Mus musculus	141-152
26449737-6	2017	In particular, fibronectin induced the early onset of osteogenic differentiation in mESCs, as confirmed by gene expression of osteogenic markers, and resulted in the three-fold higher calcium deposition at day 11 of osteogenic culture compared to the control group.	Calcium	184-191	fibronectin 1	Mus musculus	15-26
28478264-14	2017	Aldosterone increased vascular expression of fibronectin and PAI-1 in wild-type mice but not in Nox1-knockout mice.	Aldosterone	0-11	fibronectin 1	Mus musculus	45-56
27753092-9	2017	This effect might be responsible for the increased immunoreactivity for fibronectin and the decreased activation of microglia and macrophages in injured mice treated with salubrinal, compared with injured controls.	salubrinal	171-181	fibronectin 1	Mus musculus	72-83
26455905-8	2017	Furthermore, PDLSC/JBMMSC compound CAs highly expressed ALP, Col-I, fibronectin, integrin-beta1 and periostin, suggesting that their biofunction is more appropriate for periodontal structure regeneration.	Calcium	35-38	fibronectin 1	Mus musculus	68-79
28159318-5	2017	In streptozotocin-induced diabetes of these knockout mice, the pronounced fall in circulating fibronectin resulted in a decrease in mesangial expansion by 25% and a decline in albuminuria by 30% compared to diabetic control mice.	Streptozocin	3-17	fibronectin 1	Mus musculus	94-105
28159318-7	2017	In vitro experiments confirmed that matrix accumulation of fibronectin was enhanced by increasing fibronectin only, glucose only, or the combination of both.	Glucose	116-123	fibronectin 1	Mus musculus	59-70
29069762-7	2017	Treatment of the cell lines with small molecule inhibitors specific for Btk (ibrutinib) or PI3K (idelalisib), which is upstream of Akt, resulted in reduced viability, proliferation and fibronectin-dependent cell adhesion.	idelalisib	97-107	fibronectin 1	Mus musculus	185-196
28178689-4	2017	Expression of CAFs specific proteins markers in MCs, including fibroblast activation protein (FAP), alpha-smooth muscle actin (alpha-SMA), and fibronectin, were increased after treatment of exosomes.	cafs	14-18	fibronectin 1	Mus musculus	143-154
29069762-7	2017	Treatment of the cell lines with small molecule inhibitors specific for Btk (ibrutinib) or PI3K (idelalisib), which is upstream of Akt, resulted in reduced viability, proliferation and fibronectin-dependent cell adhesion.	ibrutinib	77-86	fibronectin 1	Mus musculus	185-196
28316141-7	2017	Since integrin-induced cell spreading suppresses RhoA activation, we examined the effect of dasatinib on cell spreading on fibronectin substrate.	Dasatinib	92-101	fibronectin 1	Mus musculus	123-134
28348210-0	2017	Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.	Proline	29-36	fibronectin 1	Mus musculus	61-72
30271843-3	2017	EpH4 and/or 3T3L1 cells were cultured with or without the FN-treated GM in round U-bottom wells of 96-multiwell culture plates which had been coated with poly (vinyl alcohol) (PVA) to allow the cells to form their aggregates.	gm	69-71	fibronectin 1	Mus musculus	58-60
30271843-4	2017	On the other hand, EpH4 cells were precultured with the FN-treated GM, and then continued to culture with 3T3L1 cells in the same condition described above.	gm	67-69	fibronectin 1	Mus musculus	56-58
30271843-6	2017	When 3T3L1 cells were incubated with the original and GM-preincubated EpH4 cells in the presence of both the FN-treated GM, the number of alive cells in the aggregates was significantly high compared with that for the absence of FN-treated GM.	gm	54-56	fibronectin 1	Mus musculus	109-111
30271843-6	2017	When 3T3L1 cells were incubated with the original and GM-preincubated EpH4 cells in the presence of both the FN-treated GM, the number of alive cells in the aggregates was significantly high compared with that for the absence of FN-treated GM.	gm	54-56	fibronectin 1	Mus musculus	229-231
30271843-6	2017	When 3T3L1 cells were incubated with the original and GM-preincubated EpH4 cells in the presence of both the FN-treated GM, the number of alive cells in the aggregates was significantly high compared with that for the absence of FN-treated GM.	gm	120-122	fibronectin 1	Mus musculus	109-111
30271843-6	2017	When 3T3L1 cells were incubated with the original and GM-preincubated EpH4 cells in the presence of both the FN-treated GM, the number of alive cells in the aggregates was significantly high compared with that for the absence of FN-treated GM.	gm	120-122	fibronectin 1	Mus musculus	109-111
30271843-7	2017	In addition, higher beta-casein expression level of EpH4 cells in EpH4/3T3L1 cells aggregates in the presence of FN-treated GM was observed than that of cells in the absence of FN-treated GM.	gm	124-126	fibronectin 1	Mus musculus	113-115
30271843-7	2017	In addition, higher beta-casein expression level of EpH4 cells in EpH4/3T3L1 cells aggregates in the presence of FN-treated GM was observed than that of cells in the absence of FN-treated GM.	gm	188-190	fibronectin 1	Mus musculus	177-179
30271843-8	2017	Laminin secretion was also promoted for the cells aggregates cultured with FN-treated GM.	gm	86-88	fibronectin 1	Mus musculus	75-77
30271843-9	2017	It is concluded that the presence of FN-treated GM in the EpH4/3T3L1 cells aggregates gave a better condition to cells, resulting in an enhanced generation of beta-casein from EpH4 cells in the aggregates.	gm	48-50	fibronectin 1	Mus musculus	37-39
28475311-0	2017	Targeting and Internalization of Liposomes by Bladder Tumor Cells Using a Fibronectin Attachment Protein-Derived Peptide-Lipopolymer Conjugate.	peptide-lipopolymer	113-132	fibronectin 1	Mus musculus	74-85
28475311-1	2017	A synthetic peptidolipopolymer conjugate, incorporated into liposomes to promote specific binding to the fibronectin (FBN) matrix surrounding bladder tumor cells and promote cellular internalization of FBN-integrin complexes, is reported.	peptidolipopolymer	12-30	fibronectin 1	Mus musculus	105-116
28475311-1	2017	A synthetic peptidolipopolymer conjugate, incorporated into liposomes to promote specific binding to the fibronectin (FBN) matrix surrounding bladder tumor cells and promote cellular internalization of FBN-integrin complexes, is reported.	peptidolipopolymer	12-30	fibronectin 1	Mus musculus	118-121
28475311-1	2017	A synthetic peptidolipopolymer conjugate, incorporated into liposomes to promote specific binding to the fibronectin (FBN) matrix surrounding bladder tumor cells and promote cellular internalization of FBN-integrin complexes, is reported.	peptidolipopolymer	12-30	fibronectin 1	Mus musculus	202-205
28286065-0	2017	Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys.	polydatin	0-9	fibronectin 1	Mus musculus	115-117
28518115-4	2017	EBs can be seeded on fibronectin-coated coverslips, where they expand by growing two dimensional (2D) extensions, or implanted in 3D collagen matrices where they continue growing as spheroids, and differentiate into the three germ layers: endodermal, mesodermal, and ectodermal.	ethylbenzene	0-3	fibronectin 1	Mus musculus	21-32
33429625-4	2017	We found that the ribbons functionalized with a solution of 3,4-dihydroxy-l-phenylalanine (DOPA) and then coated with poly-l-lysine (PLL) and fibronectin (FN) improve cell attachment and support the growth of C2C12.	Levodopa	60-89	fibronectin 1	Mus musculus	142-153
28230093-5	2017	Furthermore, PBP abolished TGF-beta-mediated repression of E-cadherin expression, in addition to the induction of vimentin expression and N-cadherin and fibronectin upregulation, thus blocking TGF-beta-induced epithelial-mesenchymal transition in A549 and NMuMG cells.	pentabromophenol	13-16	fibronectin 1	Mus musculus	153-164
28327179-0	2017	Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis.	pterostilbene	0-13	fibronectin 1	Mus musculus	71-82
28167045-9	2017	DEX-Ac treatment led to increased expression of fibronectin, collagen I, and alpha-smooth muscle actin in the TM in mouse eyes.	dexamethasone acetate	0-6	fibronectin 1	Mus musculus	48-59
27984337-9	2017	High-dosed cholecalciferol treatment induced vascular calcification and upregulated aortic osteogenic markers Msx2, Cbfa1 and Alpl and collagen type I (Col1a1), collagen type III (Col3a1) and fibronectin (Fbn) mRNA expression in mice, effects reduced by additional treatment with MgCl2.	Cholecalciferol	11-26	fibronectin 1	Mus musculus	192-203
27984337-9	2017	High-dosed cholecalciferol treatment induced vascular calcification and upregulated aortic osteogenic markers Msx2, Cbfa1 and Alpl and collagen type I (Col1a1), collagen type III (Col3a1) and fibronectin (Fbn) mRNA expression in mice, effects reduced by additional treatment with MgCl2.	Cholecalciferol	11-26	fibronectin 1	Mus musculus	205-208
28225832-9	2017	In addition, bilirubin treatment decreased fibronectin expression in tubular epithelial cells in a dose-dependent manner (P &lt; 0.05).	Bilirubin	13-22	fibronectin 1	Mus musculus	43-54
28128219-0	2017	Astrocyte-derived tissue Transglutaminase affects fibronectin deposition, but not aggregation, during cuprizone-induced demyelination.	Cuprizone	102-111	fibronectin 1	Mus musculus	50-61
28128219-7	2017	Enhanced presence of soluble monomeric and multimeric fibronectin was detected during demyelination, and fibronectin immunoreactivity was slightly decreased in cuprizone-treated TG2-/- mice.	Cuprizone	160-169	fibronectin 1	Mus musculus	105-116
28128219-9	2017	TG2 contributes, at least partly, to fibronectin production, and may play a role in fibronectin deposition during cuprizone-induced demyelination.	Cuprizone	114-123	fibronectin 1	Mus musculus	84-95
27999189-6	2017	In addition, Snail overexpression increased the expression of connective tissue growth factor (CTGF) and fibronectin, while Snail knockdown attenuated high glucose-induced increases in fibronectin and CTGF expression.	Glucose	156-163	fibronectin 1	Mus musculus	185-196
27902771-4	2016	Piceatannol suppressed extracellular matrix (ECM) protein deposition including collagen type I and fibronectin as well as connective tissue growth factor (CTGF) and alpha-smooth muscle actin (alpha-SMA) in UUO kidneys.	3,3',4,5'-tetrahydroxystilbene	0-11	fibronectin 1	Mus musculus	99-110
27784694-8	2017	EP4 agonist CAY10598 attenuated increased expression of collagen I and fibronectin induced by TGF-beta1 in inner medullary collecting duct 3 cells.	CAY10598	12-20	fibronectin 1	Mus musculus	71-82
27836895-11	2017	Lower abundance of fibronectin, cardiac damage (Hematoxylin Eosin-Y), and MMP9 were observed in quercetin-fed vs. control Mdx/Utrn+/- mice.	Quercetin	96-105	fibronectin 1	Mus musculus	19-30
28194406-6	2017	Furthermore, the upregulated protein and mRNA expressions of collagen IV and fibronectin in the renal cortices of the db/db mice were inhibited by curcumin treatment.	Curcumin	147-155	fibronectin 1	Mus musculus	77-88
27576129-2	2017	Using the pan-Nox inhibitor diphenyleneiodonium (DPI) as an initial tool, we show that gene expression of collagen type I, alpha-smooth muscle actin (alpha-SMA) and fibronectin 1 is suppressed in HDFs.	diphenyleneiodonium	28-47	fibronectin 1	Mus musculus	165-178
27576129-2	2017	Using the pan-Nox inhibitor diphenyleneiodonium (DPI) as an initial tool, we show that gene expression of collagen type I, alpha-smooth muscle actin (alpha-SMA) and fibronectin 1 is suppressed in HDFs.	diphenyleneiodonium	49-52	fibronectin 1	Mus musculus	165-178
27612648-0	2016	Controlled formaldehyde fixation of fibronectin layers for expansion of mesenchymal stem cells.	Formaldehyde	11-23	fibronectin 1	Mus musculus	36-47
27612648-6	2016	Thus, controlled formaldehyde fixation of layers formed by fibronectin or some other extracellular matrix components represents a simple and reproducible way to enhance proliferation of primary cells.	Formaldehyde	17-29	fibronectin 1	Mus musculus	59-70
27612826-0	2016	Effect of fibronectin adsorption on osteoblastic cellular responses to hydroxyapatite and alumina.	Durapatite	71-85	fibronectin 1	Mus musculus	10-21
27270426-4	2017	We also demonstrated that the acquisitions of pemetrexed resistance enhances epithelial-mesenchymal transition (EMT) in vivo with a mice animal model and in vitro with CL1 and A549 sublines, which was associated with upregulation of ZEB1 which, in turn, downregulates E-cadherin and upregulates fibronectin.	Pemetrexed	46-56	fibronectin 1	Mus musculus	295-306
27378149-2	2016	Our recent study found that andrographolide inhibited high glucose-induced mesangial cell proliferation and fibronectin expression through inhibition of AP-1 pathway.	andrographolide	28-43	fibronectin 1	Mus musculus	108-119
27378149-2	2016	Our recent study found that andrographolide inhibited high glucose-induced mesangial cell proliferation and fibronectin expression through inhibition of AP-1 pathway.	Glucose	59-66	fibronectin 1	Mus musculus	108-119
27748897-7	2016	Indeed, incubation of MSC with FK228 or foretinib/FK228 demonstrated morphologic alterations and enhanced expression of laminin and fibronectin.	romidepsin	31-36	fibronectin 1	Mus musculus	132-143
27748897-7	2016	Indeed, incubation of MSC with FK228 or foretinib/FK228 demonstrated morphologic alterations and enhanced expression of laminin and fibronectin.	romidepsin	50-55	fibronectin 1	Mus musculus	132-143
27867754-5	2016	Approach: A chimeric fibronectin fragment was produced by inserting the integrin-binding Arg-Gly-Asp (RGD) loop from the tenth type III repeat of fibronectin (FNIII10) into the analogous site within the heparin-binding, bioactive fragment of the first type III repeat (FNIII1H).	arginyl-glycyl-aspartic acid	89-100	fibronectin 1	Mus musculus	21-32
27867754-5	2016	Approach: A chimeric fibronectin fragment was produced by inserting the integrin-binding Arg-Gly-Asp (RGD) loop from the tenth type III repeat of fibronectin (FNIII10) into the analogous site within the heparin-binding, bioactive fragment of the first type III repeat (FNIII1H).	arginyl-glycyl-aspartic acid	89-100	fibronectin 1	Mus musculus	146-157
27867754-5	2016	Approach: A chimeric fibronectin fragment was produced by inserting the integrin-binding Arg-Gly-Asp (RGD) loop from the tenth type III repeat of fibronectin (FNIII10) into the analogous site within the heparin-binding, bioactive fragment of the first type III repeat (FNIII1H).	Heparin	203-210	fibronectin 1	Mus musculus	21-32
27867754-5	2016	Approach: A chimeric fibronectin fragment was produced by inserting the integrin-binding Arg-Gly-Asp (RGD) loop from the tenth type III repeat of fibronectin (FNIII10) into the analogous site within the heparin-binding, bioactive fragment of the first type III repeat (FNIII1H).	Heparin	203-210	fibronectin 1	Mus musculus	146-157
27510385-11	2016	The mRNA levels of collagen, collagen-1, procollagen, fibronectin, and transforming growth factor-beta in the metformin-treated mice were lower than those in the BLM-only mice on day 21, although statistical significance was observed only in the case of procollagen due to the small number of live mice in the BLM-only group.	Metformin	110-119	fibronectin 1	Mus musculus	54-65
27278287-6	2016	Treatment with Trichostatin A (TSA), a broad-spectrum HDAC inhibitor, restored their physical association, and attenuated Ang-II-induced MMP9 expression, IL-18 induction, and extracellular matrix (collagen I, collagen III and fibronectin) production.	trichostatin A	15-29	fibronectin 1	Mus musculus	226-237
27278287-6	2016	Treatment with Trichostatin A (TSA), a broad-spectrum HDAC inhibitor, restored their physical association, and attenuated Ang-II-induced MMP9 expression, IL-18 induction, and extracellular matrix (collagen I, collagen III and fibronectin) production.	trichostatin A	31-34	fibronectin 1	Mus musculus	226-237
27612826-0	2016	Effect of fibronectin adsorption on osteoblastic cellular responses to hydroxyapatite and alumina.	Aluminum Oxide	90-97	fibronectin 1	Mus musculus	10-21
27595237-4	2016	Fibronectin promoted inflammation by suppressing anti-inflammatory cAMP.	Cyclic AMP	67-71	fibronectin 1	Mus musculus	0-11
27595237-6	2016	Instead, cells on fibronectin suppressed cAMP via enhanced phosphodiesterase (PDE) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5 (PDE4D5), which induced PP2A-dependent dephosphorylation of PDE4D5 on the inhibitory site Ser651.	Cyclic AMP	41-45	fibronectin 1	Mus musculus	18-29
27498780-5	2016	RESULTS: Glucose (1-40 mmol/L) and Ang II (10-8-10-5 mol/L) dose-dependently increased the expression of fibronectin, collagens, phospho-ERK1/2 and phospho-NF-kappaB-p65 in cardiac fibroblasts.	Glucose	9-16	fibronectin 1	Mus musculus	105-116
27498780-7	2016	ERK1/2 inhibitor U0126 (10 mumol/L) and NF-kappaB inhibitor JSH-23 (10 mumol/L) both markedly suppressed glucose- and angiotensin II-induced fibronectin and collagen expressions in cardiac fibroblasts.	U 0126	17-22	fibronectin 1	Mus musculus	141-152
27498780-7	2016	ERK1/2 inhibitor U0126 (10 mumol/L) and NF-kappaB inhibitor JSH-23 (10 mumol/L) both markedly suppressed glucose- and angiotensin II-induced fibronectin and collagen expressions in cardiac fibroblasts.	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine	60-66	fibronectin 1	Mus musculus	141-152
27498780-7	2016	ERK1/2 inhibitor U0126 (10 mumol/L) and NF-kappaB inhibitor JSH-23 (10 mumol/L) both markedly suppressed glucose- and angiotensin II-induced fibronectin and collagen expressions in cardiac fibroblasts.	Glucose	105-112	fibronectin 1	Mus musculus	141-152
27373678-0	2016	Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin and p21(WAF1) in mesangial cells.	Glucose	50-57	fibronectin 1	Mus musculus	66-77
27373678-6	2016	HG increased mRNA while chaetocin increased transcription of fibronectin and p21(WAF1)genes.	chaetocin	24-33	fibronectin 1	Mus musculus	61-72
27373678-7	2016	Both HG and chaetocin decreased histone H3K9me3 levels at the promoters of fibronectin and p21(WAF1) genes.	chaetocin	12-21	fibronectin 1	Mus musculus	75-86
27373678-10	2016	Moreover, LY294002 or the dominant-negative phosphoinositide 3-kinase (PI3K) mutant (Deltap85) attenuated HG-decreased Suv39h1 and HG-induced fibronectin and p21(WAF1) protein expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	fibronectin 1	Mus musculus	142-153
27573203-7	2016	Results showed that curcumin decreased E-cadherin, N-cadherin, beta-catenin, Slug, AXL, Twist1, Vimentin and Fibronectin protein expression, independently of the positivity of the markers in the cell lines.	Curcumin	20-28	fibronectin 1	Mus musculus	109-120
27292126-7	2016	CREB1 and its downstream fibronectin (FN, extracellular matrix) were increased in HFD/STZ-treated mice, which was reversed by kidney miR-10a overexpression.	Streptozocin	86-89	fibronectin 1	Mus musculus	25-36
27292126-9	2016	Furthermore, histone deacetylase 3 (HDAC3) was revealed to be increased in kidney of HFD/STZ mice, accompanied with the augmentation of ACR ratio and FN level.	Streptozocin	89-92	fibronectin 1	Mus musculus	150-152
27292126-10	2016	Knockdown of HDAC3 with siRNA significantly caused the increase of miR-10a, resulting in the decrease in CREB1 and FN expression in kidney of HFD/STZ mice.	Streptozocin	146-149	fibronectin 1	Mus musculus	115-117
27509062-5	2016	Here we tested the efficacy of mimgamma-BiPPB (referred to as "Fibroferon") targeted to PDGFbetaR-overexpressing interstitial myofibroblasts to attenuate renal fibrosis without inducing inflammation-mediated side effects in the mouse unilateral ureter obstruction model.Unilateral ureter obstruction induced renal fibrosis characterized by significantly increased alpha-SMA, TGFbeta1, fibronectin, and collagens I and III protein and/or mRNA expression.	mimgamma-bippb	31-45	fibronectin 1	Mus musculus	385-396
27292126-7	2016	CREB1 and its downstream fibronectin (FN, extracellular matrix) were increased in HFD/STZ-treated mice, which was reversed by kidney miR-10a overexpression.	Streptozocin	86-89	fibronectin 1	Mus musculus	38-40
27464733-5	2016	Exogenous legumain promoted degradation of fibronectin and collagen I, which was abolished by administration of a legumain inhibitor RR-11a.	RR-11a	133-139	fibronectin 1	Mus musculus	43-54
27226136-4	2016	In male db/db mice, a 10-week treatment with empagliflozin attenuated the diabetes-induced upregulation of profibrotic gene markers, fibronectin and transforming-growth-factor-beta.	empagliflozin	45-58	fibronectin 1	Mus musculus	133-144
27468384-9	2016	Administration of NaHS markedly decreased the biomarkers of fibrosis such as alpha-smooth muscle actin, collagen-I, collagen-III, fibronectin, transforming growth factor-beta1, Smad2/3 phosphorylation and inflammation including the marker protein of monocyte/macrophage and monocyte chemoattractant protein-1 in the lung.	sodium bisulfide	18-22	fibronectin 1	Mus musculus	130-141
26178456-4	2016	RESULTS: Baicalein attenuated renal fibrosis by ameliorating kidney injury, reducing deposition of fibronectin and collagen type 1, and inducing apoptosis in myofibroblasts in the UUO mouse model.	baicalein	9-18	fibronectin 1	Mus musculus	99-110
27050799-6	2016	The results showed OMT significantly prevented kidney injury and fibrosis, as evidenced by decreased expression of collagen-1 and fibronectin.	oxymatrine	19-22	fibronectin 1	Mus musculus	115-141
27350122-4	2016	Compared to polydimethylsiloxane (PDMS) microcontact printed (muprinted) with fibronectin (FN), cell adhesion on gelatin hydrogel constructs was significantly higher one week and three weeks after initiating differentiation.	baysilon	12-32	fibronectin 1	Mus musculus	78-89
27235712-16	2016	Berberine reverted mesenchymal markers, vimentin and fibronectin, with restoration of epithelial marker E-cadherin, highlighting the role of berberine in reversal of EMT.	Berberine	0-9	fibronectin 1	Mus musculus	53-64
27145454-11	2016	The impeded cancer progression was due to the inhibitory effect of metformin on STAT3-ERK-vimentin and fibronectin-integrin signaling to decrease tumor cell invasion and de-differentiation.	Metformin	67-76	fibronectin 1	Mus musculus	103-114
27060978-8	2016	The combined effects of RLX + TFF2 + DEX significantly reversed peribronchial inflammation score, airway epithelial damage, subepithelial extracellular matrix accumulation/fibronectin deposition and total lung collagen concentration (by 50-90%) and also normalized the reduction of cDyn.	Dexamethasone	37-40	fibronectin 1	Mus musculus	172-183
27160937-7	2016	Although administration of diabetic mice with nobiletin did not significantly effect the level of blood glucose, it decreased the TGF-beta1, CTGF, fibronectin, and collagen Ialpha expressions and blunted cardiac fibrosis.	nobiletin	46-55	fibronectin 1	Mus musculus	147-158
26948947-1	2016	We previously demonstrated that activation of sphingosine kinase 1 (SphK1)- sphingosine 1- phosphate (S1P) signaling pathway by high glucose (HG) plays a pivotal role in increasing the expression of fibronectin (FN), an important fibrotic component, by promoting the DNA-binding activity of transcription factor activator protein 1 (AP-1) in glomerular mesangial cells (GMCs) under diabetic conditions.	sphingosine 1-phosphate	76-100	fibronectin 1	Mus musculus	199-210
26948947-1	2016	We previously demonstrated that activation of sphingosine kinase 1 (SphK1)- sphingosine 1- phosphate (S1P) signaling pathway by high glucose (HG) plays a pivotal role in increasing the expression of fibronectin (FN), an important fibrotic component, by promoting the DNA-binding activity of transcription factor activator protein 1 (AP-1) in glomerular mesangial cells (GMCs) under diabetic conditions.	sphingosine 1-phosphate	76-100	fibronectin 1	Mus musculus	212-214
26948947-1	2016	We previously demonstrated that activation of sphingosine kinase 1 (SphK1)- sphingosine 1- phosphate (S1P) signaling pathway by high glucose (HG) plays a pivotal role in increasing the expression of fibronectin (FN), an important fibrotic component, by promoting the DNA-binding activity of transcription factor activator protein 1 (AP-1) in glomerular mesangial cells (GMCs) under diabetic conditions.	Glucose	133-140	fibronectin 1	Mus musculus	199-210
26948947-1	2016	We previously demonstrated that activation of sphingosine kinase 1 (SphK1)- sphingosine 1- phosphate (S1P) signaling pathway by high glucose (HG) plays a pivotal role in increasing the expression of fibronectin (FN), an important fibrotic component, by promoting the DNA-binding activity of transcription factor activator protein 1 (AP-1) in glomerular mesangial cells (GMCs) under diabetic conditions.	Glucose	133-140	fibronectin 1	Mus musculus	212-214
27041464-8	2016	Furthermore, ROS production and the expression of p47 (a key subunit of NADPH oxidase complexes) were increased in a time-dependent manner; the expression of fibronectin, alpha-SMA and TGF-beta were upregulated.	ros	13-16	fibronectin 1	Mus musculus	158-169
27187454-8	2016	These findings suggest that IP6 and Ins prevent the development and metastatic progression of colorectal cancer to the liver in mice by altering expression of the extracellular matrix proteins collagen IV, fibronectin and laminin; the adhesion factor receptor integrin-beta1; the proteolytic enzyme matrix metalloproteinase 9; and the angiogenic factors vascular endothelial growth factor, basic fibroblast growth factor, and transforming growth factor beta in the tumor metastasis microenvironment.	Phytic Acid	28-31	fibronectin 1	Mus musculus	206-217
26908192-5	2016	Arecoline (0.25 mM) also time-dependently (24-72h) increased fibronectin and plasminogen activator inhibitor-1 (PAI1) protein expressions.	Arecoline	0-9	fibronectin 1	Mus musculus	61-72
27045029-3	2016	Aldosterone induced aortic and small artery remodeling, impaired endothelium-dependent relaxation in WT mice, and enhanced fibronectin and collagen deposition and vascular inflammation.	Aldosterone	0-11	fibronectin 1	Mus musculus	123-134
27108902-10	2016	In addition, the protein levels of fibronectin and alpha-SMA were upregulated by UUO induction (P &lt; 0.01), and valsartan administration inhibited the protein levels of fibronectin and alpha-SMA in UUO mice (P &lt; 0.05).	Valsartan	114-123	fibronectin 1	Mus musculus	171-182
26991801-0	2016	Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1.	Curcumin	63-71	fibronectin 1	Mus musculus	81-84
26991801-2	2016	FN1 is a synthetic curcumin analogue that shows stronger anticancer activity than curcumin in other reports.	Curcumin	19-27	fibronectin 1	Mus musculus	0-3
26991801-2	2016	FN1 is a synthetic curcumin analogue that shows stronger anticancer activity than curcumin in other reports.	Curcumin	82-90	fibronectin 1	Mus musculus	0-3
27161720-7	2016	RESULTS: Unfractionated heparin (UFH) and low molecular weight heparin (LMWH) both strongly inhibited migration as well as adhesion of SCLC cells to fibronectin and stromal cells.	Heparin	24-31	fibronectin 1	Mus musculus	149-160
27161720-7	2016	RESULTS: Unfractionated heparin (UFH) and low molecular weight heparin (LMWH) both strongly inhibited migration as well as adhesion of SCLC cells to fibronectin and stromal cells.	Heparin	33-36	fibronectin 1	Mus musculus	149-160
27161720-7	2016	RESULTS: Unfractionated heparin (UFH) and low molecular weight heparin (LMWH) both strongly inhibited migration as well as adhesion of SCLC cells to fibronectin and stromal cells.	Heparin	63-70	fibronectin 1	Mus musculus	149-160
27161720-7	2016	RESULTS: Unfractionated heparin (UFH) and low molecular weight heparin (LMWH) both strongly inhibited migration as well as adhesion of SCLC cells to fibronectin and stromal cells.	Heparin, Low-Molecular-Weight	72-76	fibronectin 1	Mus musculus	149-160
26719366-5	2016	The diabetic mice treated with SS-31 had alleviated proteinuria, urinary 8-hydroxy-2-deoxyguanosine level, glomerular hypertrophy, and accumulation of renal fibronectin and collagen IV.	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	31-36	fibronectin 1	Mus musculus	157-168
26898454-5	2016	However, metapristone interfered the adhesion of B16F10 cells to fibronectin by down-regulating cellular expression of integrin alpha4.	metapristone	9-21	fibronectin 1	Mus musculus	65-76
26435273-8	2016	NSPCs isolated from N-PRbeta-KO rapidly migrated on the surface coated with collagen type IV or fibronectin that are abundant in vascular niche and ischemic core.	n-prbeta	20-28	fibronectin 1	Mus musculus	96-107
26820539-6	2016	A substitution mutant of tryptophan at the position 65 to alanine in the EMI domain of periostin, which caused periostin to lose its ability to interact with fibronectin, did not decrease the accumulation.	Tryptophan	25-35	fibronectin 1	Mus musculus	158-169
26908192-8	2016	SP600125, but not SB431542 (a TGF-beta receptor type I kinase inhibitor), attenuated arecoline-induced fibronectin and PAI1 protein expressions.	pyrazolanthrone	0-8	fibronectin 1	Mus musculus	103-114
26908192-8	2016	SP600125, but not SB431542 (a TGF-beta receptor type I kinase inhibitor), attenuated arecoline-induced fibronectin and PAI1 protein expressions.	Arecoline	85-94	fibronectin 1	Mus musculus	103-114
26908192-9	2016	Finally, tubulointerstitial fibrosis occurred and renal cortical expressions of fibronectin and PAI1 proteins increased in arecoline-fed mice at 24 weeks.	Arecoline	123-132	fibronectin 1	Mus musculus	80-91
26908192-10	2016	We concluded that arecoline induced tubulointerstitial fibrosis in mice while arecoline-induced TGF-beta and pro-fibrotic proteins (fibronectin, PAI1) are dependent on JNK in LLC-PK1 cells.	Arecoline	78-87	fibronectin 1	Mus musculus	132-143
25388157-5	2016	The real-time PCR studies showed that (1) inhalational silica induced inflammatory responses in the heart and kidney by elevated mRNA levels of TNF-alpha, IL-6 and MCP-1; (2) early fibrotic responses in the heart were observed as elevated mRNA levels of collagen I and fibronectin.	Silicon Dioxide	55-61	fibronectin 1	Mus musculus	269-280
26805826-4	2016	Our data showed that UUO induced renal fibrosis and combined with the activation of ERK signaling, the upregulation of fibronectin, collagen I, and transforming growth factor-beta (TGF-beta).	uuo	21-24	fibronectin 1	Mus musculus	119-130
26881424-9	2016	Pretreatment of bEND3 cells with C-PTIO (a NO scavenger) or U0126 (a specific ERK inhibitor) significantly reduced OGD-induced S-nitrosylation of Cav-1 in cells and blocked the secretion of Cav-1 and MMP2 and 9 into the media as well as the degradation of fibronectin and laminin beta-1 in OGD and tPA-treated cells.	U 0126	60-65	fibronectin 1	Mus musculus	256-267
26661689-0	2016	Extracellular matrix fibronectin initiates endothelium-dependent arteriolar dilatation via the heparin-binding, matricryptic RWRPK sequence of the first type III repeat of fibrillar fibronectin.	Heparin	95-102	fibronectin 1	Mus musculus	21-32
26661689-0	2016	Extracellular matrix fibronectin initiates endothelium-dependent arteriolar dilatation via the heparin-binding, matricryptic RWRPK sequence of the first type III repeat of fibrillar fibronectin.	Heparin	95-102	fibronectin 1	Mus musculus	182-193
26661689-3	2016	This vasodilatory signal requires the heparin-binding matricryptic RWRPK sequence in the first type III repeat of fibrillar fibronectin.	Heparin	38-45	fibronectin 1	Mus musculus	124-135
26661689-6	2016	Here we test the hypotheses that (i) the matricryptic heparin-binding region of the first type III repeat of fibrillar FN (FNIII1H) mediates vasodilatation, and (ii) this response is EC dependent.	Heparin	54-61	fibronectin 1	Mus musculus	119-121
26661689-6	2016	Here we test the hypotheses that (i) the matricryptic heparin-binding region of the first type III repeat of fibrillar FN (FNIII1H) mediates vasodilatation, and (ii) this response is EC dependent.	Heparin	54-61	fibronectin 1	Mus musculus	123-130
26661689-8	2016	Both FNIII1H,8-10 and FNIII1H induced dilatations (12.2 +- 1.7 mum, n = 12 and 17.2 +- 2.4 mum, n = 14, respectively) whereas mutation of the active sequence (R(613) WRPK) of the heparin binding region significantly diminished the dilatation (3.2 +- 1.8 mum, n = 10).	Heparin	179-186	fibronectin 1	Mus musculus	22-29
26763945-11	2016	Furthermore, FAK inhibitor decreases lung fibrotic score, collagen accumulation, fibronectin production, and myofibroblast differentiation in in bleomycin-challenged mice.	Bleomycin	145-154	fibronectin 1	Mus musculus	81-92
26806752-0	2016	[Effect of DPP4 inhibitor sitagliptin on expressions of early growth response-1 and fibronectin in the kidney of ApoE gene knockout mice].	Sitagliptin Phosphate	26-37	fibronectin 1	Mus musculus	84-95
26603313-10	2016	In cultured tubular cells, anti-HMGB1 pretreatment also prevented the increases in fibronectin and collagen IV levels associated with CsA treatment.	Cyclosporine	134-137	fibronectin 1	Mus musculus	83-94
26437580-7	2016	Key transcription factors and other regulatory molecules (ERK, FN1, TNFSF12 and PI3K complex) activated in inflammation were down-regulated by dietary intervention with curcumin.	Curcumin	169-177	fibronectin 1	Mus musculus	63-66
26806752-1	2016	OBJECTIVE: To investigate the effects of the DPP4 inhibitor sitagliptin on the expressions of early growth response-1 (Egr-1) and fibronectin in the kidney of ApoE gene knockout mice.	Sitagliptin Phosphate	60-71	fibronectin 1	Mus musculus	130-141
26806752-10	2016	CONCLUSION: Sitagliptin can reduce the renal expression of fibronectin by regulating the expression of Egr-1 to achieve renal protection.	Sitagliptin Phosphate	12-23	fibronectin 1	Mus musculus	59-70
26415777-2	2015	We probed the contribution of cell-adhesive glycoproteins fibronectin (Fn) and vitronectin (Vn) in the initial adhesion of MC3T3-E1 osteoblastic cells to poly(NaSS) functionalized and control Ti6Al4V surfaces.	poly	154-158	fibronectin 1	Mus musculus	58-69
26517238-6	2015	Serum or fibronectin stimulation of focal adhesion kinase (FAK) autophosphorylation on tyrosine-397 was increased by either knockdown or ablation of RNase L.	Tyrosine	87-95	fibronectin 1	Mus musculus	9-20
26272391-4	2015	RESULTS: EGCG (500 and 1000 mg/kg d) induced cardiac collagen synthesis and fibrosis-related protein expression, such as connective tissue growth factor (CTGF) and fibronectin (FN) in mice.	epigallocatechin gallate	9-13	fibronectin 1	Mus musculus	164-175
26577699-6	2015	Furthermore, loss of the Fbln5-integrin interaction augmented fibronectin signaling, driving integrin-induced ROS production in a 5-lipooxygenase-dependent manner.	Reactive Oxygen Species	110-113	fibronectin 1	Mus musculus	62-73
26415777-4	2015	Compared to ungrafted surfaces, poly(NaSS) grafted surfaces enhanced the levels of cell adhesion, cell spreading and the formation of intracellular actin cytoskeleton and focal contacts in serum treatments where Fn or Vn were present (FBS, DD+Fn, DD+Vn).	poly	32-36	fibronectin 1	Mus musculus	212-214
26415777-4	2015	Compared to ungrafted surfaces, poly(NaSS) grafted surfaces enhanced the levels of cell adhesion, cell spreading and the formation of intracellular actin cytoskeleton and focal contacts in serum treatments where Fn or Vn were present (FBS, DD+Fn, DD+Vn).	poly	32-36	fibronectin 1	Mus musculus	243-245
26415777-4	2015	Compared to ungrafted surfaces, poly(NaSS) grafted surfaces enhanced the levels of cell adhesion, cell spreading and the formation of intracellular actin cytoskeleton and focal contacts in serum treatments where Fn or Vn were present (FBS, DD+Fn, DD+Vn).	nass	37-41	fibronectin 1	Mus musculus	212-214
26415777-4	2015	Compared to ungrafted surfaces, poly(NaSS) grafted surfaces enhanced the levels of cell adhesion, cell spreading and the formation of intracellular actin cytoskeleton and focal contacts in serum treatments where Fn or Vn were present (FBS, DD+Fn, DD+Vn).	nass	37-41	fibronectin 1	Mus musculus	243-245
26415777-6	2015	Secondly, blocking Fn and Vn integrin receptors using antibodies to alpha5beta1 (Fn) and alphavbeta1 (Vn) showed that adhesion of cells to poly(NaSS) grafted surfaces principally involved the Fn integrin receptor alpha5beta1.	nass	144-148	fibronectin 1	Mus musculus	19-21
26415777-6	2015	Secondly, blocking Fn and Vn integrin receptors using antibodies to alpha5beta1 (Fn) and alphavbeta1 (Vn) showed that adhesion of cells to poly(NaSS) grafted surfaces principally involved the Fn integrin receptor alpha5beta1.	nass	144-148	fibronectin 1	Mus musculus	81-83
26415777-10	2015	The aim was to probe the contribution of cell adhesive glycoproteins fibronectin and vitronectin in the initial adhesion of MC3T3-E1 osteoblastic cells to poly(NaSS) functionalized Ti6Al4V surfaces.	titanium alloy (TiAl6V4)	181-188	fibronectin 1	Mus musculus	69-80
26458186-6	2015	In vitro studies using cultured mouse CFb showed that dasatinib treatment at 50 nM reduced: (i) extracellular accumulation of both collagen and fibronectin, (ii) both basal and PDGF-stimulated activation of Pyk2, (iii) nuclear accumulation of Ki67, SKP2 and histone-H2B and (iv) PDGF-stimulated CFb proliferation and migration.	Dasatinib	54-63	fibronectin 1	Mus musculus	144-155
26298168-5	2015	We tested the effects of triptolide treatment on migration and invasion of lung cancer cells by using Transwell filters coated with fibronectin and Matrigel, respectively.	triptolide	25-35	fibronectin 1	Mus musculus	132-143
25788524-5	2015	Conversely, inhibition of the channels by 2-aminoethyl diphenylborinate significantly increased the expression of fibronectin and collagen IV.	2-aminoethyl diphenylborinate	42-71	fibronectin 1	Mus musculus	114-125
25788524-7	2015	Furthermore, 2-aminoethyl diphenylborinate significantly augmented angiotensin II-induced fibronectin protein expression, whereas thapsigargin abrogated high glucose- and TGF-beta1-stimulated matrix protein expression.	2-aminoethyl diphenylborinate	13-42	fibronectin 1	Mus musculus	90-101
26121313-13	2015	Additionally, PGE2 and TGFbeta increased fibronectin levels, reaching 12-fold upon co-stimulation.	Dinoprostone	14-18	fibronectin 1	Mus musculus	41-52
25586556-6	2015	Coadministration of the PPARgamma antagonist, GW9662, reversed the enhanced efferocytosis, and the reduced proinflammatory cytokine expression, neutrophil recruitment, myeloperoxidase activity, hydroxyproline contents, and fibrosis markers, including type 1 collagen alpha2, fibronectin and alpha-smooth muscle actin (alpha-SMA), in the lung by apoptotic cell instillation.	2-chloro-5-nitrobenzanilide	46-52	fibronectin 1	Mus musculus	275-286
26292037-6	2015	At a later stage, we provided the samples with a stable fibronectin coating, by covalently binding the protein on the polymer surface, thus enabling long-term cultures with C2C12 skeletal muscle cells, a more controllable cell type.	Polymers	118-125	fibronectin 1	Mus musculus	56-67
26225535-0	2015	Controlled Assembly of Fibronectin Nanofibrils Triggered by Random Copolymer Chemistry.	copolymer	67-76	fibronectin 1	Mus musculus	23-34
26225535-2	2015	Poly(ethyl acrylate), PEA, has been described to induce a similar process upon simple adsorption of fibronectin (FN) from a protein solution-in the absence of cells-leading to the so-called material-driven fibronectin fibrillogenesis.	poly	0-4	fibronectin 1	Mus musculus	100-111
26225535-2	2015	Poly(ethyl acrylate), PEA, has been described to induce a similar process upon simple adsorption of fibronectin (FN) from a protein solution-in the absence of cells-leading to the so-called material-driven fibronectin fibrillogenesis.	poly	0-4	fibronectin 1	Mus musculus	113-115
26225535-2	2015	Poly(ethyl acrylate), PEA, has been described to induce a similar process upon simple adsorption of fibronectin (FN) from a protein solution-in the absence of cells-leading to the so-called material-driven fibronectin fibrillogenesis.	poly	0-4	fibronectin 1	Mus musculus	206-217
26225535-2	2015	Poly(ethyl acrylate), PEA, has been described to induce a similar process upon simple adsorption of fibronectin (FN) from a protein solution-in the absence of cells-leading to the so-called material-driven fibronectin fibrillogenesis.	ethyl acrylate	5-19	fibronectin 1	Mus musculus	100-111
26225535-2	2015	Poly(ethyl acrylate), PEA, has been described to induce a similar process upon simple adsorption of fibronectin (FN) from a protein solution-in the absence of cells-leading to the so-called material-driven fibronectin fibrillogenesis.	ethyl acrylate	5-19	fibronectin 1	Mus musculus	113-115
26225535-2	2015	Poly(ethyl acrylate), PEA, has been described to induce a similar process upon simple adsorption of fibronectin (FN) from a protein solution-in the absence of cells-leading to the so-called material-driven fibronectin fibrillogenesis.	ethyl acrylate	5-19	fibronectin 1	Mus musculus	206-217
26225535-3	2015	Poly(methyl acrylate), PMA, is a polymer with very similar chemistry to PEA, on which FN is adsorbed, keeping the globular conformation of the protein in solution.	poly(methyl acrylate)	0-21	fibronectin 1	Mus musculus	86-88
26225535-3	2015	Poly(methyl acrylate), PMA, is a polymer with very similar chemistry to PEA, on which FN is adsorbed, keeping the globular conformation of the protein in solution.	Polymers	33-40	fibronectin 1	Mus musculus	86-88
26225535-4	2015	We have used radical polymerization to synthesize copolymers with controlled EA/MA ratio, seeking to modulate the degree of FN fibrillogenesis.	copolymers	50-60	fibronectin 1	Mus musculus	124-126
26225535-8	2015	Myogenic differentiation was enhanced on the copolymers with higher EA content, i.e. more interconnected FN fibrils.	copolymers	45-55	fibronectin 1	Mus musculus	105-107
26225535-8	2015	Myogenic differentiation was enhanced on the copolymers with higher EA content, i.e. more interconnected FN fibrils.	ea	68-70	fibronectin 1	Mus musculus	105-107
26255261-5	2015	Herein, the synergistic outcome of co-application of Fn and nHA incorporation into aligned electrospun polycaprolactone (PCL) seeded by mouse mesenchymal stem cells (MSC) was investigated both in vitro and in vivo.	polycaprolactone	103-119	fibronectin 1	Mus musculus	53-55
26255261-5	2015	Herein, the synergistic outcome of co-application of Fn and nHA incorporation into aligned electrospun polycaprolactone (PCL) seeded by mouse mesenchymal stem cells (MSC) was investigated both in vitro and in vivo.	polycaprolactone	121-124	fibronectin 1	Mus musculus	53-55
25728989-5	2015	As a proof-of-concept, the integrin-binding tripeptide Arg-Gly-Asp (RGD) sequence from fibronectin was integrated into mouse amelogenin (rM179) at three different positions.	tripeptide K-26	44-54	fibronectin 1	Mus musculus	87-98
25728989-5	2015	As a proof-of-concept, the integrin-binding tripeptide Arg-Gly-Asp (RGD) sequence from fibronectin was integrated into mouse amelogenin (rM179) at three different positions.	Arginine	55-58	fibronectin 1	Mus musculus	87-98
25728989-5	2015	As a proof-of-concept, the integrin-binding tripeptide Arg-Gly-Asp (RGD) sequence from fibronectin was integrated into mouse amelogenin (rM179) at three different positions.	glycylaspartic acid	59-66	fibronectin 1	Mus musculus	87-98
26005021-9	2015	Significant 48% and 40% reductions in fibronectin expression were seen at 0.5 nM and 1 nM 1,25(OH)2D3.	Calcitriol	90-101	fibronectin 1	Mus musculus	38-49
26092126-4	2015	Pharmacological inhibition of GSK3 using TDZD-8 starting before or after ischemia-reperfusion significantly suppressed renal fibrosis by reducing the myofibroblast population, collagen-1 and fibronectin deposition, inflammatory cytokines, and macrophage infiltration.	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	41-47	fibronectin 1	Mus musculus	176-202
25952902-13	2015	PASMC adhesion to fibronectin was higher in Hspg2(Delta3/Delta3) compared with wild type.	pasmc	0-5	fibronectin 1	Mus musculus	18-29
25993691-2	2015	Here, we report that the alternatively spliced EDA domain of fibronectin, a marker of angiogenesis and of tissue remodeling, is expressed in the dextran sodium sulfate mouse model of colitis and in patients with inflammatory bowel conditions, while being virtually undetectable in most normal adult tissues.	dextran sodium sulfate	145-167	fibronectin 1	Mus musculus	61-72
26081605-3	2015	The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.	Arginine	30-33	fibronectin 1	Mus musculus	123-134
26081605-3	2015	The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.	Aspartic Acid	38-41	fibronectin 1	Mus musculus	123-134
25981879-3	2015	Baicalein treatment significantly attenuated tubulointerstitial fibrosis by markedly reducing fibronectin and collagen-I.	baicalein	0-9	fibronectin 1	Mus musculus	94-105
26061387-8	2015	DHI improved renal functions by inhibiting mesangial matrix expansion, expression of vascular endothelial growth factor A, fibronectin and advanced glycation end products in kidneys.	dehydrosoyasaponin I	0-3	fibronectin 1	Mus musculus	123-134
25909163-4	2015	In addition to activation of AMPK and suppression of the mTOR pathway, a series of increased and decreased genes expression were induced by metformin, including PTEN, MMP7, and FN1.	Metformin	140-149	fibronectin 1	Mus musculus	177-180
25703166-6	2015	In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-beta, type IV collagen, alpha-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling.	ONO 1301	35-43	fibronectin 1	Mus musculus	147-158
25955525-4	2015	EGCG attenuated BDL-induced gene expression of pro-fibrotic markers (Collagen, Fibronectin, alpha 2 smooth muscle actin or SMA and connective tissue growth factor or CTGF), mitochondrial oxidative stress, cell death marker (DNA fragmentation and PARP activity), NFkappaB activity and pro-inflammatory cytokines (TNFalpha, MIP1alpha, IL1beta, and MIP2).	epigallocatechin gallate	0-4	fibronectin 1	Mus musculus	79-90
25955525-6	2015	EGCG also attenuated hydrogen peroxide induced cell death in hepatocytes in vitro and alleviate stellate cells mediated fibrosis through TIMP1, SMA, Collagen 1 and Fibronectin in vitro.	epigallocatechin gallate	0-4	fibronectin 1	Mus musculus	164-175
25955532-6	2015	Upregulation of these TGF-beta signaling components correlated with upregulation of fibrosis markers collagen 1 and fibronectin, responses that were inhibited by administration of the TGF-beta receptor 1 inhibitors SB431542 or GW788388.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	215-223	fibronectin 1	Mus musculus	116-127
25955532-6	2015	Upregulation of these TGF-beta signaling components correlated with upregulation of fibrosis markers collagen 1 and fibronectin, responses that were inhibited by administration of the TGF-beta receptor 1 inhibitors SB431542 or GW788388.	4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide	227-235	fibronectin 1	Mus musculus	116-127
25504047-6	2015	This integrin-beta1 N-glycosylation pattern was correlated with higher levels of membrane-bound integrin-beta1 and also with increased binding to fibronectin.	Nitrogen	20-21	fibronectin 1	Mus musculus	146-157
25541330-4	2015	Carbon tetrachloride treatment significantly increased alpha-smooth muscle actin, fibronectin, and collagen I levels in wild-type mice, which were unaffected in periostin-knockout mice.	Carbon Tetrachloride	0-20	fibronectin 1	Mus musculus	82-93
25555155-3	2015	In this study, we use an optical biosensing technique to decipher the properties of fibronectin (Fn) and serum albumin adsorbed on parylene-C and silicon oxide substrates.	parylene	131-141	fibronectin 1	Mus musculus	84-95
25555155-3	2015	In this study, we use an optical biosensing technique to decipher the properties of fibronectin (Fn) and serum albumin adsorbed on parylene-C and silicon oxide substrates.	parylene	131-141	fibronectin 1	Mus musculus	97-99
25555155-3	2015	In this study, we use an optical biosensing technique to decipher the properties of fibronectin (Fn) and serum albumin adsorbed on parylene-C and silicon oxide substrates.	silicon oxide	146-159	fibronectin 1	Mus musculus	84-95
25555155-3	2015	In this study, we use an optical biosensing technique to decipher the properties of fibronectin (Fn) and serum albumin adsorbed on parylene-C and silicon oxide substrates.	silicon oxide	146-159	fibronectin 1	Mus musculus	97-99
25555155-6	2015	These results suggest that Fn acquires a compact structure on parylene-C and a more extended structure on silicon oxide.	parylene	62-70	fibronectin 1	Mus musculus	27-29
25555155-6	2015	These results suggest that Fn acquires a compact structure on parylene-C and a more extended structure on silicon oxide.	silicon oxide	106-119	fibronectin 1	Mus musculus	27-29
25555155-7	2015	Nonetheless, parylene-C and silicon oxide substrates coated with Fn host cell populations that exhibit focal adhesion complexes and good cell attachment.	parylene	13-23	fibronectin 1	Mus musculus	65-67
25555155-7	2015	Nonetheless, parylene-C and silicon oxide substrates coated with Fn host cell populations that exhibit focal adhesion complexes and good cell attachment.	silicon oxide	28-41	fibronectin 1	Mus musculus	65-67
25555155-9	2015	Interestingly, the co-incubation of Fn and albumin at the ratio found in serum, results in the preferential adsorption of albumin on parylene-C and Fn on silicon oxide.	parylene	133-143	fibronectin 1	Mus musculus	36-38
25555155-9	2015	Interestingly, the co-incubation of Fn and albumin at the ratio found in serum, results in the preferential adsorption of albumin on parylene-C and Fn on silicon oxide.	silicon oxide	154-167	fibronectin 1	Mus musculus	36-38
25555155-9	2015	Interestingly, the co-incubation of Fn and albumin at the ratio found in serum, results in the preferential adsorption of albumin on parylene-C and Fn on silicon oxide.	silicon oxide	154-167	fibronectin 1	Mus musculus	148-150
25510317-9	2015	The SD-induced upregulation of fibronectin and collagen type I was suppressed by SU11652, an inhibitor of PDGFRbeta, while PDGF-B further increased the SD-induced upregulation.	SU 11652	81-88	fibronectin 1	Mus musculus	31-42
25510317-9	2015	The SD-induced upregulation of fibronectin and collagen type I was suppressed by SU11652, an inhibitor of PDGFRbeta, while PDGF-B further increased the SD-induced upregulation.	SD 0006	4-6	fibronectin 1	Mus musculus	31-42
25482070-5	2015	High glucose and exogenous S100B (1 microM) time-dependently increased p21WAF1 gene transcription and protein expression, increased type IV collagen and fibronectin protein expression, and TGF-beta gene transcription and bioactivity.	Glucose	5-12	fibronectin 1	Mus musculus	153-164
25482070-10	2015	Additionally, high glucose-induced pro-fibrotic genes (TGF-beta, type IV collagen and fibronectin) and cell hypertrophy-related p21WAF1 are dependent on S100B.	Glucose	19-26	fibronectin 1	Mus musculus	86-97
25389299-8	2015	Akt1 KO fibroblasts displayed reduced adhesion to fibronectin with manganese stimulation when compared with WT and DKO cells, revealing an Akt1-dependent role for TSP2 in regulating integrin-mediated adhesions; however, this effect was not due to changes in beta1 integrin surface expression or activation.	Manganese	67-76	fibronectin 1	Mus musculus	50-61
26025398-4	2015	And demonstrated that fibronectin (FN) in EPCs activated the integrin &amp;#945;5&amp;#946;1 of MSCs and further mediated cell-cell cohesion.	Adenosine Monophosphate	71-74	fibronectin 1	Mus musculus	22-33
26025398-4	2015	And demonstrated that fibronectin (FN) in EPCs activated the integrin &amp;#945;5&amp;#946;1 of MSCs and further mediated cell-cell cohesion.	Adenosine Monophosphate	71-74	fibronectin 1	Mus musculus	35-37
26025398-4	2015	And demonstrated that fibronectin (FN) in EPCs activated the integrin &amp;#945;5&amp;#946;1 of MSCs and further mediated cell-cell cohesion.	Adenosine Monophosphate	82-85	fibronectin 1	Mus musculus	22-33
26025398-4	2015	And demonstrated that fibronectin (FN) in EPCs activated the integrin &amp;#945;5&amp;#946;1 of MSCs and further mediated cell-cell cohesion.	Adenosine Monophosphate	82-85	fibronectin 1	Mus musculus	35-37
26025398-5	2015	Integrin &amp;#945;5&amp;#946;1 and its FN ligand played critical roles not only in single&amp;mdash;cell line adhesion, but also in adhesion between stem and niche cells.	Adenosine Monophosphate	10-13	fibronectin 1	Mus musculus	40-42
25411386-7	2015	Inhibition of the beta-catenin degradation with pyrvinium pamoate (pyr; 10(-9) M) prevented the ANG II-induced expression of fibronectin, collagen I, and beta-catenin target genes.	pyrvinium	48-65	fibronectin 1	Mus musculus	125-136
25411386-7	2015	Inhibition of the beta-catenin degradation with pyrvinium pamoate (pyr; 10(-9) M) prevented the ANG II-induced expression of fibronectin, collagen I, and beta-catenin target genes.	pyrvinium	48-51	fibronectin 1	Mus musculus	125-136
25703166-6	2015	In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-beta, type IV collagen, alpha-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling.	Glucose	183-190	fibronectin 1	Mus musculus	147-158
26394244-9	2015	Furthermore, the increased protein and mRNA expression of alpha-smooth muscle actin (alpha-Sma), fibronectin and collagen type I in the obstructed kidney tissues following UUO were significantly attenuated following NH4Cl treatment.	Ammonium Chloride	216-221	fibronectin 1	Mus musculus	97-108
26115221-3	2015	Cells pretreated with rapamycin before exposure to HG showed significant decrease phosphorylation of CREB, increase in AMPK activity and decrease protein/mRNA and promoter activity of fibronectin.	Sirolimus	22-31	fibronectin 1	Mus musculus	184-195
26115221-6	2015	Moreover, gel shift analysis shows increase binding of CREB to fibronectin promoter in cells treated with HG while cells pretreated with rapamycin reversed the effect of HG.	Sirolimus	137-146	fibronectin 1	Mus musculus	63-74
26115221-7	2015	Furthermore, db/db mice treated with rapamycin showed significant increase in AMPK activity, decrease in expression of p-CREB and protein/mRNA of fibronectin.	Sirolimus	37-46	fibronectin 1	Mus musculus	146-157
26115221-8	2015	Strong staining of fibronectin and p-CREB was detected in kidney cortex of db/db mice while treated mice with rapamycin reversed hyperglycemia effect.	Sirolimus	110-119	fibronectin 1	Mus musculus	19-30
26885500-5	2015	This effect was concomitant with a much lessened accumulation of fibronectin and collagen in tubulointerstitium 28 days after folic acid injury, denoting an ameliorated renal fibrosis.	Folic Acid	126-136	fibronectin 1	Mus musculus	65-76
26184741-4	2015	FN isforms-induced gene expression and lipid accumulation were inhibited by a chemical chaperone 4-phenyl butyric acid (PBA) or by overexpression of the ER chaperone, GRP78/BiP, demonstrating a direct role of ER stress in activation of cholesterol/triglyceride biosynthesis.	4-phenylbutyric acid	97-118	fibronectin 1	Mus musculus	0-2
26184741-4	2015	FN isforms-induced gene expression and lipid accumulation were inhibited by a chemical chaperone 4-phenyl butyric acid (PBA) or by overexpression of the ER chaperone, GRP78/BiP, demonstrating a direct role of ER stress in activation of cholesterol/triglyceride biosynthesis.	4-phenylbutyric acid	120-123	fibronectin 1	Mus musculus	0-2
26184741-4	2015	FN isforms-induced gene expression and lipid accumulation were inhibited by a chemical chaperone 4-phenyl butyric acid (PBA) or by overexpression of the ER chaperone, GRP78/BiP, demonstrating a direct role of ER stress in activation of cholesterol/triglyceride biosynthesis.	Cholesterol	236-247	fibronectin 1	Mus musculus	0-2
26184741-4	2015	FN isforms-induced gene expression and lipid accumulation were inhibited by a chemical chaperone 4-phenyl butyric acid (PBA) or by overexpression of the ER chaperone, GRP78/BiP, demonstrating a direct role of ER stress in activation of cholesterol/triglyceride biosynthesis.	Triglycerides	248-260	fibronectin 1	Mus musculus	0-2
26184741-6	2015	CONCLUSION: our study suggests that enhanced FN in lesions facilitates foam cell formation due to dysregulation of the endogenous sterol response pathway by activation of ER stress, and confirms that EDA+FN has no more pro-atherogenic role than EDA-FN in triggering ER stress.	Sterols	130-136	fibronectin 1	Mus musculus	45-47
25205656-3	2014	In particular, the IL2 cytokine and the disulfide-linked maytansinoid DM1 microtubular inhibitor could be coupled to the F8 antibody, directed against the alternatively spliced EDA domain of fibronectin, in a site-specific manner, yielding a chemically defined product with selective tumor-homing performance and potent anticancer activity in vivo, as tested in two different immunocompetent mouse models.	Disulfides	40-49	fibronectin 1	Mus musculus	191-202
25288788-6	2014	Notably, FoxO1 regulates high glucose-induced protein synthesis, hypertrophy, and expression of fibronectin and PAI-1.	Glucose	30-37	fibronectin 1	Mus musculus	96-107
25288788-10	2014	Moreover, we show that catalase blocks high glucose-stimulated Akt phosphorylation to attenuate the inactivation of FoxO1 and PRAS40, resulting in the inhibition of mTORC1 and mesangial cell hypertrophy and fibronectin and PAI-1 expression.	Glucose	44-51	fibronectin 1	Mus musculus	207-218
25054428-0	2014	Poly(NaSS) functionalization modulates the conformation of fibronectin and collagen type I to enhance osteoblastic cell attachment onto Ti6Al4V.	poly(nass)	0-10	fibronectin 1	Mus musculus	59-70
24978608-6	2014	Sesamin blocked upregulation of the mesenchymal markers (fibronectin and vimentin) and downregulation of the epithelial marker (E-cadherin), indicating an inhibitory effect on TGF-beta1-induced EMT in A549 cells.	sesamin	0-7	fibronectin 1	Mus musculus	57-68
25172494-8	2014	In vivo neutralization of sIL-6Ralpha attenuated pulmonary fibrosis in mice as seen by reductions in myofibroblasts, fibronectin, and collagen in the lung.	sil-6ralpha	26-37	fibronectin 1	Mus musculus	117-128
25047515-6	2014	In addition, the induced expression of collagen and fibronectin and three-dimensional collagen gel contraction were also significantly inhibited in AZD0530-treated fibroblasts.	saracatinib	148-155	fibronectin 1	Mus musculus	52-63
25054428-8	2014	Fn adapts a conformation favorable to RGD mediated cell attachment when adsorbed onto poly(NaSS).	poly	86-90	fibronectin 1	Mus musculus	0-2
25054428-8	2014	Fn adapts a conformation favorable to RGD mediated cell attachment when adsorbed onto poly(NaSS).	nass	91-95	fibronectin 1	Mus musculus	0-2
24833701-7	2014	In a mouse model of obstructive nephropathy, administration of sirtinol attenuated deposition of collagen fibrils as well as reduced expression of alpha-smooth muscle actin, collagen I, and fibronectin in the injured kidney.	sirtinol	63-71	fibronectin 1	Mus musculus	190-201
24842243-9	2014	Furthermore, sitagliptin significantly decreased levels of MCD diet-induced fibrosis-associated proteins such as fibronectin and alpha-SMA in the liver.	Sitagliptin Phosphate	13-24	fibronectin 1	Mus musculus	113-124
25237577-0	2014	Fibronectin regulation by vitamin C treatment in kidneys of nicotinic mice offspring.	Ascorbic Acid	26-35	fibronectin 1	Mus musculus	0-11
25237577-4	2014	OBJECTIVES: This study decided to investigate the effects of vitamin C on fibronectin expression in kidneys of mice offspring, treated with nicotine.	Ascorbic Acid	61-70	fibronectin 1	Mus musculus	74-85
25237577-4	2014	OBJECTIVES: This study decided to investigate the effects of vitamin C on fibronectin expression in kidneys of mice offspring, treated with nicotine.	Nicotine	140-148	fibronectin 1	Mus musculus	74-85
25237577-9	2014	CONCLUSIONS: This study revealed that vitamin C could reduce the fibronectin accumulation effects of nicotine on kidney.	Ascorbic Acid	38-47	fibronectin 1	Mus musculus	65-76
25237577-9	2014	CONCLUSIONS: This study revealed that vitamin C could reduce the fibronectin accumulation effects of nicotine on kidney.	Nicotine	101-109	fibronectin 1	Mus musculus	65-76
24972137-10	2014	Our results suggest that the renoprotective mechanism of sitagliptin may be due to a reduction in Akt levels, a restoration of AMPK activity, and inhibition of TGF-beta1, FN, and p38/ERK MAPK signaling pathways.	Sitagliptin Phosphate	57-68	fibronectin 1	Mus musculus	171-173
24698256-8	2014	These ameliorative effects of GW501516 on Ang II-induced aneurysm were correlated with increased expression of extracellular matrix (ECM) proteins, such as types I and III collagen, fibronectin, and elastin, along with the up-regulation of transforming growth factor-beta1.	GW 501516	30-38	fibronectin 1	Mus musculus	182-193
24268268-0	2014	beta-Phase poly(vinylidene fluoride) films encouraged more homogeneous cell distribution and more significant deposition of fibronectin towards the cell-material interface compared to alpha-phase poly(vinylidene fluoride) films.	polyvinylidene fluoride	11-36	fibronectin 1	Mus musculus	124-135
24518258-5	2014	Cancerous mouse mast cells, mastocytoma P-815 cells (P-815 cells) are known to bind to fibronectin through de novo synthesis of integrin subtypes by prostaglandin (PG) E2 stimulation.	Dinoprostone	149-170	fibronectin 1	Mus musculus	87-98
24518258-6	2014	The purpose of this study was to clarify the relationship between lipid raft components and the actin cytoskeleton, and PGE2-induced P-815 cells adhesion to fibronectin and the increase in surface expression and mRNA and protein levels of alphavbeta3 and alphaIIbbeta3 integrins.	Dinoprostone	120-124	fibronectin 1	Mus musculus	157-168
24530578-5	2014	Further, both the subunits of integrin receptors for fibronectin (alpha5beta1) and laminin (alpha3beta1) on B16BL6 cells were shown to carry these oligosaccharides.	Oligosaccharides	147-163	fibronectin 1	Mus musculus	53-64
24296280-9	2014	Instead, we found that the fibronectin/alpha5-subunit integrin ratio is profoundly altered in MR(SMKO) mice because the induction of alpha5 expression by aldosterone/salt challenge is prevented in mice lacking VSMC MR.	Aldosterone	154-165	fibronectin 1	Mus musculus	27-38
24296280-9	2014	Instead, we found that the fibronectin/alpha5-subunit integrin ratio is profoundly altered in MR(SMKO) mice because the induction of alpha5 expression by aldosterone/salt challenge is prevented in mice lacking VSMC MR.	Salts	166-170	fibronectin 1	Mus musculus	27-38
24342608-4	2014	In line with this, TGF-beta-mediated expression of the EMT marker fibronectin was inhibited not only by chemicals that interfere with ROS signaling but also by exogenously expressed mitochondrial thioredoxin (TXN2) independent of Smad signaling.	Reactive Oxygen Species	134-137	fibronectin 1	Mus musculus	66-77
24631250-5	2014	Gene expression analysis showed that cells grown in alginate and alginate-HA present increased differentiation toward neural lineages with respect to the two-dimensional control and to Fn group.	Alginates	52-60	fibronectin 1	Mus musculus	185-187
24631250-5	2014	Gene expression analysis showed that cells grown in alginate and alginate-HA present increased differentiation toward neural lineages with respect to the two-dimensional control and to Fn group.	Alginates	65-73	fibronectin 1	Mus musculus	185-187
24357118-8	2014	In vivo, megakaryocyte expression of fibronectin and basement membrane components was upregulated during bone marrow reconstitution upon 5-fluorouracil induced myelosuppression, while only type IV collagen resulted upregulated upon induced thrombocytopenia.	Fluorouracil	137-151	fibronectin 1	Mus musculus	37-48
24468139-4	2014	METHODS AND RESULTS: Streptozotocin-induced diabetes in atherosclerosis-prone ApoE knockout mice promoted transitional matrix expression (fibronectin, thrombospondin-1) and deposition in intima of the aortic arch as determined by qRT-PCR array and immunohistochemistry.	Streptozocin	21-35	fibronectin 1	Mus musculus	138-149
24468139-7	2014	Laminar flow significantly blunted high glucose-induced fibronectin expression (mRNA and protein) and fibronectin fibrillogenesis in endothelial cell culture models, whereas high glucose-induced fibronectin deposition was similar between disturbed flow and static conditions.	Glucose	40-47	fibronectin 1	Mus musculus	56-67
25562158-4	2014	RESULTS: Compared to normal fibroblast (NF), the expression of collagen and fibronectin in SSc (SScF) dramatically increased, and this could be reduced by Astragaloside IV (AST) in a dose- or time-dependent manner at both protein and mRNA levels.	astragaloside A	155-171	fibronectin 1	Mus musculus	76-87
25562158-4	2014	RESULTS: Compared to normal fibroblast (NF), the expression of collagen and fibronectin in SSc (SScF) dramatically increased, and this could be reduced by Astragaloside IV (AST) in a dose- or time-dependent manner at both protein and mRNA levels.	astragaloside A	173-176	fibronectin 1	Mus musculus	76-87
25562158-5	2014	Administration of Astragaloside IV consistently decreased collagen formation and partially restored the structure, as well as suppressing collagen and fibronectin expression in the skin lesions of SSc-model mice.	astragaloside	18-31	fibronectin 1	Mus musculus	151-162
24239745-6	2014	Pharmacologic inhibition of AMCase with ip allosamidin inhibited both OVA induced increases in esophageal eosinophilic inflammation and OVA induced esophageal remodeling (fibrosis, epithelial basal zone hyperplasia, extracellular matrix deposition of fibronectin).	allosamidin	43-54	fibronectin 1	Mus musculus	251-262
24268268-8	2014	Increased fibronectin adsorption towards the cell-material interface was shown on beta-phase PVDF films.	polyvinylidene fluoride	93-97	fibronectin 1	Mus musculus	10-21
25140114-5	2014	In line with the improvement of kidney morphology, rotenone remarkably blunted fibrotic response as shown by downregulation of fibronectin (FN), plasminogen activator inhibitor-1 (PAI-1), collagen I, collagen III, and alpha-SMA, paralleled with a substantial decrease of TGF-beta 1.	Rotenone	51-59	fibronectin 1	Mus musculus	127-138
25140114-5	2014	In line with the improvement of kidney morphology, rotenone remarkably blunted fibrotic response as shown by downregulation of fibronectin (FN), plasminogen activator inhibitor-1 (PAI-1), collagen I, collagen III, and alpha-SMA, paralleled with a substantial decrease of TGF-beta 1.	Rotenone	51-59	fibronectin 1	Mus musculus	140-142
23950936-9	2013	In cultured MEF from CTGF+/+ mice, glucose (25 mM) increased expression of pro-collagens 1, IV and XVIII as well as fibronectin and thrombospondin 1 (TSP1).	Glucose	35-42	fibronectin 1	Mus musculus	116-127
23808384-7	2013	Furthermore, LPA2 deficiency attenuated the bleomycin-induced expression of fibronectin (FN), alpha-smooth muscle actin (alpha-SMA), and collagen in lung tissue, as well as levels of IL-6, transforming growth factor-beta (TGF-beta), and total protein in bronchoalveolar lavage fluid.	Bleomycin	44-53	fibronectin 1	Mus musculus	76-87
23808384-7	2013	Furthermore, LPA2 deficiency attenuated the bleomycin-induced expression of fibronectin (FN), alpha-smooth muscle actin (alpha-SMA), and collagen in lung tissue, as well as levels of IL-6, transforming growth factor-beta (TGF-beta), and total protein in bronchoalveolar lavage fluid.	Bleomycin	44-53	fibronectin 1	Mus musculus	89-91
24171489-8	2013	Cell behavior was highly dependent on pH during multilayer formation with heparin as polyanion and was closely related to fibronectin adsorption.	Heparin	74-81	fibronectin 1	Mus musculus	122-133
23640035-6	2013	The real-time PCR and pathology results showed that the neutralization of IL-1beta attenuated silica-induced fibrosis by inhibiting the gene expression of transforming growth factor-beta 1, collagen I and fibronectin.	Silicon Dioxide	94-100	fibronectin 1	Mus musculus	190-216
23887603-6	2013	The antibody-based pharmacodelivery of TNF by the fusion protein "F8-TNF" to oncofetal fibronectin in sarcoma-bearing mice leads to complete and long-lasting tumour eradications when administered in combination with doxorubicin, the first-line drug for the treatment of sarcomas in humans.	Doxorubicin	216-227	fibronectin 1	Mus musculus	87-98
24268243-7	2014	It is found that the amount of fibronectin adsorption on the three [CS/polyanion] systems is significantly determined by the sum of the functional group of COO(-) and OCN on the surfaces of [CS/Alg], [CS/PGA] and [CS/PAsp] systems.	Cesium	68-70	fibronectin 1	Mus musculus	31-42
24268243-7	2014	It is found that the amount of fibronectin adsorption on the three [CS/polyanion] systems is significantly determined by the sum of the functional group of COO(-) and OCN on the surfaces of [CS/Alg], [CS/PGA] and [CS/PAsp] systems.	polyanions	71-80	fibronectin 1	Mus musculus	31-42
24268243-7	2014	It is found that the amount of fibronectin adsorption on the three [CS/polyanion] systems is significantly determined by the sum of the functional group of COO(-) and OCN on the surfaces of [CS/Alg], [CS/PGA] and [CS/PAsp] systems.	carboxyl radical	156-162	fibronectin 1	Mus musculus	31-42
24268243-7	2014	It is found that the amount of fibronectin adsorption on the three [CS/polyanion] systems is significantly determined by the sum of the functional group of COO(-) and OCN on the surfaces of [CS/Alg], [CS/PGA] and [CS/PAsp] systems.	ocn	167-170	fibronectin 1	Mus musculus	31-42
24268243-7	2014	It is found that the amount of fibronectin adsorption on the three [CS/polyanion] systems is significantly determined by the sum of the functional group of COO(-) and OCN on the surfaces of [CS/Alg], [CS/PGA] and [CS/PAsp] systems.	Cesium	191-193	fibronectin 1	Mus musculus	31-42
24268243-7	2014	It is found that the amount of fibronectin adsorption on the three [CS/polyanion] systems is significantly determined by the sum of the functional group of COO(-) and OCN on the surfaces of [CS/Alg], [CS/PGA] and [CS/PAsp] systems.	Cesium	191-193	fibronectin 1	Mus musculus	31-42
24268243-7	2014	It is found that the amount of fibronectin adsorption on the three [CS/polyanion] systems is significantly determined by the sum of the functional group of COO(-) and OCN on the surfaces of [CS/Alg], [CS/PGA] and [CS/PAsp] systems.	poly(gamma-glutamic acid)	204-207	fibronectin 1	Mus musculus	31-42
24268243-7	2014	It is found that the amount of fibronectin adsorption on the three [CS/polyanion] systems is significantly determined by the sum of the functional group of COO(-) and OCN on the surfaces of [CS/Alg], [CS/PGA] and [CS/PAsp] systems.	Cesium	191-193	fibronectin 1	Mus musculus	31-42
24268243-7	2014	It is found that the amount of fibronectin adsorption on the three [CS/polyanion] systems is significantly determined by the sum of the functional group of COO(-) and OCN on the surfaces of [CS/Alg], [CS/PGA] and [CS/PAsp] systems.	polyaspartate	217-221	fibronectin 1	Mus musculus	31-42
24006257-9	2013	This suggests that, downstream of FN binding, paxillin-pY118 requires Rgnef GEF activity through a mechanism distinct from adhesion formation and FAK activation.	paxillin-py118	46-60	fibronectin 1	Mus musculus	34-36
23786998-5	2013	Immunofluorescence analysis showed that fibronectin was overexpressed in ClC-3(+/+) DOCA-salt mice.	Desoxycorticosterone Acetate	84-88	fibronectin 1	Mus musculus	40-51
23786998-5	2013	Immunofluorescence analysis showed that fibronectin was overexpressed in ClC-3(+/+) DOCA-salt mice.	Salts	89-93	fibronectin 1	Mus musculus	40-51
23974695-8	2013	P-3F(ax)-Neu5Ac-treated cancer cells exhibited impaired binding to poly-l-lysine, type I collagen, and fibronectin and diminished migratory capacity.	N-Acetylneuraminic Acid	9-15	fibronectin 1	Mus musculus	82-114
23793581-9	2013	In vitro, glucose induced collagen I A1 promoter activation and collagen I, fibronectin and CTGF protein upregulation in WT but not KO MCs.	Glucose	10-17	fibronectin 1	Mus musculus	76-87
23678045-6	2013	In cultured mouse proximal tubular epithelial cells (MCTs), high glucose increases ADAM17 activity, Nox4 and fibronectin expression, cellular collagen content, and NADPH oxidase activity.	Glucose	65-72	fibronectin 1	Mus musculus	109-120
23571270-11	2013	In contrast, cells grown on the integrin ligands fibronectin and laminin displayed increased FAK 576/577 Tyr-P that was augmented by CB1 agonists and blocked by the Src inhibitor PP2 and Flk-1 VEGFR antagonist SU5416.	tyr-p	105-110	fibronectin 1	Mus musculus	49-60
24156020-1	2013	L19-tumor necrosis factor alpha (L19mTNF-alpha; L), a fusion protein consisting of mouse TNFalpha and the human antibody fragment L19 directed to the extra domain-B (ED-B) of fibronectin, is able to selectively target tumor vasculature and to exert a long-lasting therapeutic activity in combination with melphalan (M) in syngeneic mouse tumor models.	Melphalan	305-314	fibronectin 1	Mus musculus	175-186
23571270-11	2013	In contrast, cells grown on the integrin ligands fibronectin and laminin displayed increased FAK 576/577 Tyr-P that was augmented by CB1 agonists and blocked by the Src inhibitor PP2 and Flk-1 VEGFR antagonist SU5416.	Semaxinib	210-216	fibronectin 1	Mus musculus	49-60
23494951-5	2013	SEM/EDAX showed the presence of calcium-and phosphorus-containing particles on untreated and treated disks that were more numerous on fibronectin-coated disks.	Calcium	32-39	fibronectin 1	Mus musculus	134-145
23494951-5	2013	SEM/EDAX showed the presence of calcium-and phosphorus-containing particles on untreated and treated disks that were more numerous on fibronectin-coated disks.	Phosphorus	44-54	fibronectin 1	Mus musculus	134-145
23421903-3	2013	In earlier work, we reported that EtOH increased the expression in lung fibroblasts of fibronectin, a matrix glycoprotein implicated in lung injury and repair.	Ethanol	34-38	fibronectin 1	Mus musculus	87-98
23778885-6	2013	After FN treatment, the phosphorylation of cMet at Tyr 1313 and the activity of the PLCgamma/DAG/PKC signaling pathway was increased in Hca-F cells compared with Hca-P cells.	Tyrosine	51-54	fibronectin 1	Mus musculus	6-8
23500140-8	2013	Additionally, high glucose-induced p21(WAF1), fibronectin protein expression and cell hypertrophy were attenuated by UCHL5 shRNA.	Glucose	19-26	fibronectin 1	Mus musculus	46-57
23347386-10	2013	Curcumin treatment reduced mRNA expression of inflammatory proteins monocyte chemoattractant protein-1 and transforming growth factor-beta and matrix proteins, fibronectin, laminin and collagen.	Curcumin	0-8	fibronectin 1	Mus musculus	160-171
23615786-5	2013	The presence of the cell-binding domain sequence and the mannose groups within the transferred molecules was revealed by anti-fibronectin monoclonal antibody immunolabelling and FITC-Concanavalin-A staining, respectively.	Mannose	57-64	fibronectin 1	Mus musculus	126-137
24053909-10	2013	The levels of TGF-beta and fibronectin in silica exposed mice were significantly elevated than those in control mice at days 28 and 84 after treatment (P &lt; 0.01).	Silicon Dioxide	42-48	fibronectin 1	Mus musculus	27-38
24053909-11	2013	And the mRNA levels of TGF-beta, collagen I and fibronectin were significantly decreased in silica+IL-1beta mAb group when compared with those in silica group at days 7, 28 and 84 (P &lt; 0.01).	Silicon Dioxide	92-98	fibronectin 1	Mus musculus	48-59
23421903-11	2013	Dihydro-beta-erythroidin hydrobromide, a competitive inhibitor of alpha4 nAChR, blocked the increase in fibronectin expression and cell proliferation.	dihydro-beta-erythroidin hydrobromide	0-37	fibronectin 1	Mus musculus	104-115
23421903-12	2013	Furthermore, EtOH-induced fibronectin expression was inhibited in cells silenced for alpha4 nAChR.	Ethanol	13-17	fibronectin 1	Mus musculus	26-37
23421903-14	2013	Knowing there are several important cysteine residues near the ligand-binding site of alpha4 nAChRs, we tested the antioxidant NAC and found that it too blocked the induction of fibronectin expression by EtOH.	Cysteine	36-44	fibronectin 1	Mus musculus	178-189
23421903-14	2013	Knowing there are several important cysteine residues near the ligand-binding site of alpha4 nAChRs, we tested the antioxidant NAC and found that it too blocked the induction of fibronectin expression by EtOH.	Acetylcysteine	127-130	fibronectin 1	Mus musculus	178-189
23421903-14	2013	Knowing there are several important cysteine residues near the ligand-binding site of alpha4 nAChRs, we tested the antioxidant NAC and found that it too blocked the induction of fibronectin expression by EtOH.	Ethanol	204-208	fibronectin 1	Mus musculus	178-189
23197406-6	2013	After 21 days, gene expression of integrin beta3, fibronectin-1, osterix, and collagen-I was increased in alginate-coated compared to TiO2 SC.	Alginates	106-114	fibronectin 1	Mus musculus	50-88
23500140-12	2013	UCHL5 is also required for high glucose-induced TGF-betaR1 protein deubiquitination, p21(WAF1) and fibronectin protein expression and cell hypertrophy.	Glucose	32-39	fibronectin 1	Mus musculus	99-110
23348422-6	2013	Exposure to PCC supernatant increased the production of platelet-derived growth factor-A, hepatic growth factor, collagen type I, fibronectin, and periostin in PSCs, which was significantly reduced by pirfenidone.	pirfenidone	201-212	fibronectin 1	Mus musculus	130-141
23675473-12	2013	At 7 days post-reperfusion both 10 and 100 ppm H2S reduced expression of fibronectin by 63% (p&lt;0.05) and 67% (p&lt;0.01) and ANP by 84% and 63% (p&lt;0.05), respectively.	Hydrogen Sulfide	47-50	fibronectin 1	Mus musculus	73-84
23274568-12	2013	A marked decrease in the expression of mesenchymal markers such as Fibronectin, N-cadherin, SNAI, Slug and Twist and an increase in epithelial cell polarity marker E-cadherin were noted in NO-sulindac-treated tumors.	Sulindac	192-200	fibronectin 1	Mus musculus	67-78
23455393-4	2013	Fibronectin increased 2-deoxyglucose (DG) uptake and GLUT-1 protein expression that were blocked by transcription or translation inhibitors.	Deoxyglucose	22-36	fibronectin 1	Mus musculus	0-11
23455393-5	2013	Integrin alpha5beta1-bound fibronectin increased 2-DG uptake through cluster formation with vascular endothelial growth factor receptor (VEGFR) 2, and then activated Ras and PI3K/Akt.	Deoxyglucose	49-53	fibronectin 1	Mus musculus	27-38
23333557-4	2013	Morphological study found that acurhagin-C dramatically affected B16-F10 cell adhesion to immobilized fibronectin, leading to the formation of multicellular aggregates with rounded shape.	acurhagin-c	31-42	fibronectin 1	Mus musculus	102-113
23637793-6	2013	Tamoxifen blocked the MMT induced by transforming growth factor (TGF)-beta1, as it preserved the expression of E-cadherin and reduced the expression of mesenchymal-associated molecules such as snail, fibronectin, collagen-I, alpha-smooth muscle actin, and matrix metalloproteinse-2.	Tamoxifen	0-9	fibronectin 1	Mus musculus	200-211
24063598-4	2013	The surface resistance to an extracellular matrix protein fibronectin increased with increasing molecular weight and concentration of PEG-thiol, and was further optimised via increasing the reaction temperature and the pH of the reactant aqueous solution.	peg-thiol	134-143	fibronectin 1	Mus musculus	58-69
23416306-5	2013	Cell surface alpha2,6-sialylation was required for integrin alpha5beta1-dependent cell adhesion to fibronectin, and an increase in alpha2,6-linked sialic acid on alpha5-subunit facilitated fibronectin-mediated focal adhesion kinase phosphorylations, suggesting that alpha2,6-sialylated alpha5-subunit promoted integrin alpha5beta1-dependent cell adhesion.	N-Acetylneuraminic Acid	147-158	fibronectin 1	Mus musculus	189-200
23088883-0	2013	Adsorption state of fibronectin on poly(dimethylsiloxane) surfaces with varied stiffness can dominate adhesion density of fibroblasts.	baysilon	35-57	fibronectin 1	Mus musculus	20-31
23123666-6	2013	The combination of CG and 3,4-DGE also caused upregulation of messenger RNA expression of transforming growth factor beta1, connective tissue growth factor, fibronectin, collagen type 1 alpha1 chain, alpha smooth muscle actin (alpha-SMA), vascular endothelial growth factor 164, NADPH oxidase 1 and 4, p22phox, p47phox, and gp91phox in peritoneal tissue.	chlorhexidine gluconate	19-21	fibronectin 1	Mus musculus	157-168
23123666-6	2013	The combination of CG and 3,4-DGE also caused upregulation of messenger RNA expression of transforming growth factor beta1, connective tissue growth factor, fibronectin, collagen type 1 alpha1 chain, alpha smooth muscle actin (alpha-SMA), vascular endothelial growth factor 164, NADPH oxidase 1 and 4, p22phox, p47phox, and gp91phox in peritoneal tissue.	3,4-dideoxyglucosone-3-ene	26-33	fibronectin 1	Mus musculus	157-168
23248239-0	2013	Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.	Azithromycin	0-12	fibronectin 1	Mus musculus	32-43
23248239-8	2013	Neutralization of active TGFbeta resulted in the ablation of azithromycin"s ability to increase fibronectin concentrations, but did not alter its ability to increase MMP-9 expression.	Azithromycin	61-73	fibronectin 1	Mus musculus	96-107
23248239-9	2013	In P. aeruginosa-infected mice, azithromycin significantly decreased MMP-9 and fibronectin concentrations in the alveolar space compared with non-treated, infected controls.	Azithromycin	32-44	fibronectin 1	Mus musculus	79-90
23082964-7	2013	Cells released from the Ca-alginate at 7 and 21 days as a result of scaffold degradation were shown to retain viability, to adhere to fibronectin in a normal manner, and continue to express VEGF, demonstrating their potential to further contribute to maintenance of cardiac function after scaffold degradation.	ca-alginate	24-35	fibronectin 1	Mus musculus	134-145
23311471-8	2013	Interestingly, the incorporation of galactose groups into the hydrogels was found to improve cell adhesion, likely due to the adsorption of fibronectin (FN) in cell-extracellular matrix (ECM).	Galactose	36-45	fibronectin 1	Mus musculus	140-151
23311471-8	2013	Interestingly, the incorporation of galactose groups into the hydrogels was found to improve cell adhesion, likely due to the adsorption of fibronectin (FN) in cell-extracellular matrix (ECM).	Galactose	36-45	fibronectin 1	Mus musculus	153-155
24389406-2	2013	Our previous studies demonstrated that three plasma proteins, fibronectin, histidine-rich glycoprotein, and fibrinogen were bound by EGCG, and that one specific domain in fibronectin was responsible for its binding interaction with EGCG.	epigallocatechin gallate	232-236	fibronectin 1	Mus musculus	171-182
23319319-4	2013	High glucose could modify ECM components assembly, by the increase in fibronectin levels and the decrease in metalloprotease ADAM12, without the effect on integrin alpha5 and beta1 subunits.	Glucose	5-12	fibronectin 1	Mus musculus	70-81
23819050-11	2013	Furthermore, increases in MMPs/TIMPs, fibronectin, type IV collagen, MCP-1, and (P)RR expression, in addition to MAPK and NF- kappa B activity, were significantly attenuated by aliskiren administration.	aliskiren	177-186	fibronectin 1	Mus musculus	38-49
24389406-2	2013	Our previous studies demonstrated that three plasma proteins, fibronectin, histidine-rich glycoprotein, and fibrinogen were bound by EGCG, and that one specific domain in fibronectin was responsible for its binding interaction with EGCG.	epigallocatechin gallate	133-137	fibronectin 1	Mus musculus	62-73
24389406-2	2013	Our previous studies demonstrated that three plasma proteins, fibronectin, histidine-rich glycoprotein, and fibrinogen were bound by EGCG, and that one specific domain in fibronectin was responsible for its binding interaction with EGCG.	epigallocatechin gallate	133-137	fibronectin 1	Mus musculus	171-182
23349910-9	2013	MMC stimulated with 30 mM D-glucose showed increased PKC and ERK mediated fibronectin and collagen type III synthesis.	Glucose	26-35	fibronectin 1	Mus musculus	74-85
23515334-4	2013	Fbg microfibers were covalently modified with fibronectin (FN) by using water-soluble 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide as the cross-linking agent.	Water	72-77	fibronectin 1	Mus musculus	46-57
23515334-4	2013	Fbg microfibers were covalently modified with fibronectin (FN) by using water-soluble 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide as the cross-linking agent.	Ethyldimethylaminopropyl Carbodiimide	86-132	fibronectin 1	Mus musculus	46-57
23349910-10	2013	Sulodexide alone significantly increased fibronectin and collagen type III synthesis in a dose-dependent manner in MMC and this increase was further enhanced in the presence of 30 mM D-glucose.	glucuronyl glucosamine glycan sulfate	0-10	fibronectin 1	Mus musculus	41-52
23349910-10	2013	Sulodexide alone significantly increased fibronectin and collagen type III synthesis in a dose-dependent manner in MMC and this increase was further enhanced in the presence of 30 mM D-glucose.	Glucose	183-192	fibronectin 1	Mus musculus	41-52
23041647-11	2012	Fibronectin and collagen expression was diminished by metformin through AMPKalpha1 activation in cultured fibroblasts.	Metformin	54-63	fibronectin 1	Mus musculus	0-11
22683701-12	2012	CONCLUSIONS: FN stimulated mESCs migration and proliferation through NHE-1 activation, which were mediated by lipid raft-associated caveolin-1, RhoA/ROCK, and Ca(2+)/CaM signaling pathways.	cafestol palmitate	166-169	fibronectin 1	Mus musculus	13-15
23042199-9	2012	Fluorofenidone also markedly reduced the expression of fibronectin, alpha-smooth muscle actin, and collagen I in mouse lung tissues.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	0-14	fibronectin 1	Mus musculus	55-66
22683701-6	2012	In addition, FN-induced increase of cell migration was inhibited by NHE-1 inhibitor amiloride or NHE-1-specific siRNA.	Amiloride	84-93	fibronectin 1	Mus musculus	13-15
22809727-8	2012	Moreover, FN reduced TNF-alpha production induced by polyI:C (TLR3 ligand), and imiquimod (TLR7 ligand), but not by LPS (TLR4 ligand), or a non-CpG pDNA/cationic liposome complex.	Poly I-C	53-60	fibronectin 1	Mus musculus	10-12
22495293-6	2012	Tacrolimus-treated and knockout mice exhibited significantly increased levels of aortic TGF-beta receptor activation as evidenced by SMAD2/3 phosphorylation, along with increased collagen and fibronectin expression compared to controls.	Tacrolimus	0-10	fibronectin 1	Mus musculus	192-203
22495293-7	2012	Treatment of isolated mouse aortas with tacrolimus increased TGF-beta receptor activation and collagen and fibronectin expression.	Tacrolimus	40-50	fibronectin 1	Mus musculus	107-118
22710062-3	2012	Undifferentiated mES cells produce fibronectin and assemble a fibrillar matrix.	2-(N-morpholino)ethanesulfonic acid	17-20	fibronectin 1	Mus musculus	35-46
22710062-5	2012	Conversely, reducing fibronectin production by mES cells growing on a feeder-free gelatin substrate caused loss of cell adhesion, decreased integrin signaling, and decreased expression of self-renewal markers.	2-(N-morpholino)ethanesulfonic acid	47-50	fibronectin 1	Mus musculus	21-32
22896860-0	2004	(64)Cu-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid-epidermal growth factor receptor-binding fibronectin domain E13.4.3" Epidermal growth factor (EGF) is a 53-amino-acid growth factor (6.2 kDa) that is secreted by ectodermic cells, monocytes, kidneys, and duodenal glands (1).	cu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid	4-63	fibronectin 1	Mus musculus	105-116
22934655-0	2012	Titanium dioxide nanoparticles disturb the fibronectin-mediated adhesion and spreading of pre-osteoblastic cells.	titanium dioxide	0-16	fibronectin 1	Mus musculus	43-54
22896860-13	2004	An engineered fibronectin scaffold with EGFR-binding domain (FnE13.4.3", 10 kDa) was radiolabeled with (64)Cu via 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) conjugation to form (64)Cu-DOTA-FnE13.4.3" as a PET probe for in vivo imaging of EGFR in tumor-bearing nude mice (22).	Copper	107-109	fibronectin 1	Mus musculus	14-25
22896860-13	2004	An engineered fibronectin scaffold with EGFR-binding domain (FnE13.4.3", 10 kDa) was radiolabeled with (64)Cu via 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) conjugation to form (64)Cu-DOTA-FnE13.4.3" as a PET probe for in vivo imaging of EGFR in tumor-bearing nude mice (22).	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid	114-170	fibronectin 1	Mus musculus	14-25
22896860-13	2004	An engineered fibronectin scaffold with EGFR-binding domain (FnE13.4.3", 10 kDa) was radiolabeled with (64)Cu via 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) conjugation to form (64)Cu-DOTA-FnE13.4.3" as a PET probe for in vivo imaging of EGFR in tumor-bearing nude mice (22).	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid	172-176	fibronectin 1	Mus musculus	14-25
22896860-13	2004	An engineered fibronectin scaffold with EGFR-binding domain (FnE13.4.3", 10 kDa) was radiolabeled with (64)Cu via 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) conjugation to form (64)Cu-DOTA-FnE13.4.3" as a PET probe for in vivo imaging of EGFR in tumor-bearing nude mice (22).	cu-dota-fne13	202-215	fibronectin 1	Mus musculus	14-25
22588949-6	2012	Relative to control, DIO enhanced M-Wnt (P = 0.01), but not E-Wnt, tumor progression; upregulated EMT- and TIC-associated markers including N-cadherin,fibronectin, TGFbeta, Snail, FOXC2, and Oct4 (P &lt; 0.05, each); and increased intratumoral adipocytes.	3,3'-Dioctadecyloxacarbocyanine perchlorate	21-24	fibronectin 1	Mus musculus	151-162
22318920-7	2012	Primary hepatocytes on fibronectin are protected from reactive oxygen species-induced cellular damage, retaining the expression of Bcl-xL, whereas those on type I collagen are not.	Reactive Oxygen Species	54-77	fibronectin 1	Mus musculus	23-34
22356773-0	2012	Fibronectin adsorption and cell response on electroactive poly(vinylidene fluoride) films.	polyvinylidene fluoride	58-83	fibronectin 1	Mus musculus	0-11
22356773-5	2012	Furthermore, by means of atomic force microscopy and an enzyme-linked immunosorbent assay test, it has been shown that positive or negative poling strongly influences the behavior of beta-PVDF supports with respect to fibronectin (FN) adsorption, varying the exhibition of adhesion ligands of adsorbed FN.	beta-pvdf	183-192	fibronectin 1	Mus musculus	218-229
22356773-5	2012	Furthermore, by means of atomic force microscopy and an enzyme-linked immunosorbent assay test, it has been shown that positive or negative poling strongly influences the behavior of beta-PVDF supports with respect to fibronectin (FN) adsorption, varying the exhibition of adhesion ligands of adsorbed FN.	beta-pvdf	183-192	fibronectin 1	Mus musculus	231-233
22356773-5	2012	Furthermore, by means of atomic force microscopy and an enzyme-linked immunosorbent assay test, it has been shown that positive or negative poling strongly influences the behavior of beta-PVDF supports with respect to fibronectin (FN) adsorption, varying the exhibition of adhesion ligands of adsorbed FN.	beta-pvdf	183-192	fibronectin 1	Mus musculus	302-304
22932188-7	2012	RESULTS: Expressions of TGF-beta1, alpha-SMA, and fibronectin were increased in CCl(4) injected mice livers, but significantly attenuated by co-treatment with CCl(4) and rhEPO.	Cefaclor	80-83	fibronectin 1	Mus musculus	50-61
22932188-7	2012	RESULTS: Expressions of TGF-beta1, alpha-SMA, and fibronectin were increased in CCl(4) injected mice livers, but significantly attenuated by co-treatment with CCl(4) and rhEPO.	Cefaclor	159-162	fibronectin 1	Mus musculus	50-61
22853894-3	2012	We found that cadherin-mediated adhesion stimulated cell spreading on FN-PAG, and this was modulated by the substrate stiffness.	phenylacetylglycine	73-76	fibronectin 1	Mus musculus	70-72
22803011-1	2012	PURPOSE: The purpose of this study was to determine whether increasing the Ti6Al4V surface oxide negative charge through heat (600C) or radiofrequency plasma glow discharge (RFGD) pretreatment, with or without a subsequent coating with fibronectin, stimulated osteoblast gene marker expression in the MC3T3 osteoprogenitor cell line.	ti6al4v surface oxide	75-96	fibronectin 1	Mus musculus	236-247
22803011-5	2012	However, pretreatments increased osteoblast gene expression for fibronectin-coated disks more than uncoated disks, suggesting a surface oxide-mediated specific enhancement of fibronectin"s bioactivity.	Oxides	136-141	fibronectin 1	Mus musculus	64-75
22803011-5	2012	However, pretreatments increased osteoblast gene expression for fibronectin-coated disks more than uncoated disks, suggesting a surface oxide-mediated specific enhancement of fibronectin"s bioactivity.	Oxides	136-141	fibronectin 1	Mus musculus	175-186
22803011-7	2012	CONCLUSIONS: The results suggest that heat and RFGD pretreatments of the Ti6Al4V surface oxide stimulated osteoblast differentiation through an enhancement of (a) coated fibronectin"s bioactivity and (b) the bioactivities of other serum or matrix proteins.	ti6al4v surface oxide	73-94	fibronectin 1	Mus musculus	170-181
22302193-6	2012	Blockade of Shh signaling with cyclopamine abolished the Shh-mediated induction of Gli1, Snail1, alpha-SMA, fibronectin, and collagen I.	cyclopamine	31-42	fibronectin 1	Mus musculus	108-119
22275174-6	2012	Polydopamine coatings were also utilized to effectively immobilize extracellular matrix proteins (i.e., fibronectin) on the surface of polydopamine-coated, electrospun fibers, resulting in enhancement of NIH3T3 cell attachment, spreading, and cytoskeletal development.	polydopamine	0-12	fibronectin 1	Mus musculus	104-115
22447768-0	2012	Influence of nanometer smoothness and fibronectin immobilization of titanium surface on MC3T3-E1 cell behavior.	Titanium	68-76	fibronectin 1	Mus musculus	38-49
22447768-3	2012	Fibronectin could be immobilized by the tresyl chloride-activation method.	2,2,2-trifluoroethanesulfonyl chloride	40-55	fibronectin 1	Mus musculus	0-11
22326534-3	2012	Treatment with Candesartan (2mg/kg per day) could effectively downregulate Smad3 and fibronectin accompanied by upregulating of Smad7.	candesartan	15-26	fibronectin 1	Mus musculus	85-96
22275174-6	2012	Polydopamine coatings were also utilized to effectively immobilize extracellular matrix proteins (i.e., fibronectin) on the surface of polydopamine-coated, electrospun fibers, resulting in enhancement of NIH3T3 cell attachment, spreading, and cytoskeletal development.	polydopamine	135-147	fibronectin 1	Mus musculus	104-115
22173161-8	2012	Fibronectin (FN) was increased in the BDL liver and was reduced by rifaximin administration and thus, was explored further in vitro as a potential mediator of paracrine interactions of HSC and LEC.	Rifaximin	67-76	fibronectin 1	Mus musculus	0-11
22173161-8	2012	Fibronectin (FN) was increased in the BDL liver and was reduced by rifaximin administration and thus, was explored further in vitro as a potential mediator of paracrine interactions of HSC and LEC.	Rifaximin	67-76	fibronectin 1	Mus musculus	13-15
22972421-4	2012	Both sulfatides significantly inhibited the adhesion of melanoma cells onto fibronectin-coated tissue plates and, the motility and invasion of the cells, with 6-sulfatide showing stronger inhibitory activities.	Sulfoglycosphingolipids	5-15	fibronectin 1	Mus musculus	76-87
22474533-4	2012	Treatment with XCHT in the STZ-diabetic mice and HG-exposed RMC resulted in a decrease in expression levels of TGF-beta1, fibronectin, and collagen IV, with concomitant increase in BMP-7 expression.	Streptozocin	27-30	fibronectin 1	Mus musculus	122-133
22675359-0	2012	MC3T3-E1 Cells on Titanium Surfaces with Nanometer Smoothness and Fibronectin Immobilization.	Titanium	18-26	fibronectin 1	Mus musculus	66-77
22161143-7	2012	Dehydroxy methyl epoxyquinomicin, a selective inhibitor of NFkappaB, partially inhibited the enhancement of fibronectin expression by TGF-beta, TNF-alpha, and IL-1beta, but not of N-cadherin expression.	dehydroxymethylepoxyquinomicin	0-32	fibronectin 1	Mus musculus	108-119
22675359-2	2012	Fibronectin could be easily immobilized by tresyl chloride-activation technique.	2,2,2-trifluoroethanesulfonyl chloride	43-58	fibronectin 1	Mus musculus	0-11
22675359-6	2012	At 11 days, sandblasted titanium surface with fibronectin immobilization showed the significantly highest cell viability than other titanium surface.	Titanium	24-32	fibronectin 1	Mus musculus	46-57
22500093-5	2012	Troglitazone resulted in an elongated morphology, 60% decreases in E-cadherin and beta-catenin, a 35% decrease in alpha-catenin, and a 1.5-fold increase in fibronectin.	Troglitazone	0-12	fibronectin 1	Mus musculus	156-167
23139787-0	2012	Inhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells.	Hyaluronic Acid	14-24	fibronectin 1	Mus musculus	56-67
21762547-0	2012	The correlation between fibronectin adsorption and fibroblast cell behaviors on chitosan/poly(epsilon-caprolactone) blend films.	polycaprolactone	89-115	fibronectin 1	Mus musculus	24-35
21997473-5	2012	We were interested in studying the C-terminal heparin-binding region of FN since it mediates aggrecan and type II collagen breakdown in cartilage, but the specific FN domains responsible for proteolytic enzyme activity and their receptors in cartilage are unknown.	Heparin	46-53	fibronectin 1	Mus musculus	72-74
21997473-7	2012	We found that the FN III 13-14 domains in the C-terminal heparin-binding region of FN are potent inducers of aggrecanase activity in articular cartilage.	Heparin	57-64	fibronectin 1	Mus musculus	18-20
21881556-7	2012	We found that in wild-type mice, CG treatment increased peritoneal permeability (measured by equilibration), increased mRNA expression of TGF-beta1, connective tissue growth factor and fibronectin, TNF-alpha and IL-1beta expression, and resulted in infiltration of CD3-positive T cells, and caused a high number of Ki-67-positive proliferating cells.	chlorhexidine gluconate	33-35	fibronectin 1	Mus musculus	185-196
23056222-7	2012	Finally, DMF suppressed unilateral ureteral obstruction (UUO)-induced renal fibrosis and alpha-SMA, fibronectin and type 1 collagen expression in the obstructed kidneys from UUO mice, along with increased and decreased expression of Nrf2 and phospho-Smad3, respectively.	Dimethyl Fumarate	9-12	fibronectin 1	Mus musculus	100-111
23401999-4	2012	During coincubation of fibroblasts with the tripeptide the stimulation of cell attachment and spreading to untreated plastic and plastic coated with fibronectin or gelatin was observed.	tripeptide K-26	44-54	fibronectin 1	Mus musculus	149-160
23401999-6	2012	Preincubation of cells with the tripeptide resulted in partial inhibition of fibroblast adhesion and spreading on fibronectin- and gelatin-coated substrata.	tripeptide K-26	32-42	fibronectin 1	Mus musculus	114-125
23401999-7	2012	In was shown that the extent of activation and inhibition of adhesive processes on fibronectin was higher than such ones on gelatin after tripeptide treating.	tripeptide K-26	138-148	fibronectin 1	Mus musculus	83-94
23401999-8	2012	The data obtained support the assumption about concerted action of tripeptide GER (activity of which was dependent both on the used concentration of the tripeptide and on the mode of tripeptide addition to culture medium) and chemical characteristics of substrate (polymers of styrene and L-lysine, ECM proteins in native (fibronectin) or partly denatured (gelatin) form) on the cell adhesion and spreading.	tripeptide K-26	67-77	fibronectin 1	Mus musculus	323-334
23401999-8	2012	The data obtained support the assumption about concerted action of tripeptide GER (activity of which was dependent both on the used concentration of the tripeptide and on the mode of tripeptide addition to culture medium) and chemical characteristics of substrate (polymers of styrene and L-lysine, ECM proteins in native (fibronectin) or partly denatured (gelatin) form) on the cell adhesion and spreading.	tripeptide K-26	153-163	fibronectin 1	Mus musculus	323-334
23401999-8	2012	The data obtained support the assumption about concerted action of tripeptide GER (activity of which was dependent both on the used concentration of the tripeptide and on the mode of tripeptide addition to culture medium) and chemical characteristics of substrate (polymers of styrene and L-lysine, ECM proteins in native (fibronectin) or partly denatured (gelatin) form) on the cell adhesion and spreading.	tripeptide K-26	153-163	fibronectin 1	Mus musculus	323-334
23401999-8	2012	The data obtained support the assumption about concerted action of tripeptide GER (activity of which was dependent both on the used concentration of the tripeptide and on the mode of tripeptide addition to culture medium) and chemical characteristics of substrate (polymers of styrene and L-lysine, ECM proteins in native (fibronectin) or partly denatured (gelatin) form) on the cell adhesion and spreading.	Styrene	277-284	fibronectin 1	Mus musculus	323-334
22407353-0	2012	Targeting focal adhesion assembly by ethoxyfagaronine prevents lymphoblastic cell adhesion to fibronectin.	N-methyl-12-ethoxy-2-hydroxy-3,8,9-trimethoxybenzo(c)phenanthridinium	37-53	fibronectin 1	Mus musculus	94-105
22407353-2	2012	We described herein the ability of ethoxyfagaronine (etxfag), a soluble synthetic derivative of fagaronine, to prevent leukemic cell adhesion to fibronectin peptide (FN/V).	N-methyl-12-ethoxy-2-hydroxy-3,8,9-trimethoxybenzo(c)phenanthridinium	35-51	fibronectin 1	Mus musculus	145-156
22407353-2	2012	We described herein the ability of ethoxyfagaronine (etxfag), a soluble synthetic derivative of fagaronine, to prevent leukemic cell adhesion to fibronectin peptide (FN/V).	N-methyl-12-ethoxy-2-hydroxy-3,8,9-trimethoxybenzo(c)phenanthridinium	53-59	fibronectin 1	Mus musculus	145-156
22407353-2	2012	We described herein the ability of ethoxyfagaronine (etxfag), a soluble synthetic derivative of fagaronine, to prevent leukemic cell adhesion to fibronectin peptide (FN/V).	fagaronine	41-51	fibronectin 1	Mus musculus	145-156
22204307-11	2011	Using C. jejuni mutant strains we further demonstrated that the fibronectin-binding protein CadF and intact flagella are involved in Cdc42-GTP induction, indicating that the bacteria may directly target the fibronectin/integrin complex for inducing signaling leading to its host cell entry.	Guanosine Triphosphate	139-142	fibronectin 1	Mus musculus	64-75
22204307-11	2011	Using C. jejuni mutant strains we further demonstrated that the fibronectin-binding protein CadF and intact flagella are involved in Cdc42-GTP induction, indicating that the bacteria may directly target the fibronectin/integrin complex for inducing signaling leading to its host cell entry.	Guanosine Triphosphate	139-142	fibronectin 1	Mus musculus	207-218
21652783-8	2011	In C2C12 myoblast cells, resveratrol pretreatment suppressed the TGF-beta1-induced increase in reactive oxygen species, fibronectin production, and expression of alpha-SMA, and SIRT1 knockdown blocked these inhibitory effects.	Resveratrol	25-36	fibronectin 1	Mus musculus	120-131
21822533-5	2011	siRNA-mediated reduction of fibronectin and interference in the liaison between fibronectin and integrins by the Arg-Gly-Asp-Ser (RGDS) peptide increased aggrecan expression, and decreased versican expression by TGF-beta1 stimulation.	Arginine	113-116	fibronectin 1	Mus musculus	80-91
21822533-5	2011	siRNA-mediated reduction of fibronectin and interference in the liaison between fibronectin and integrins by the Arg-Gly-Asp-Ser (RGDS) peptide increased aggrecan expression, and decreased versican expression by TGF-beta1 stimulation.	Glycine	117-120	fibronectin 1	Mus musculus	80-91
21822533-5	2011	siRNA-mediated reduction of fibronectin and interference in the liaison between fibronectin and integrins by the Arg-Gly-Asp-Ser (RGDS) peptide increased aggrecan expression, and decreased versican expression by TGF-beta1 stimulation.	Aspartic Acid	121-124	fibronectin 1	Mus musculus	80-91
21822533-5	2011	siRNA-mediated reduction of fibronectin and interference in the liaison between fibronectin and integrins by the Arg-Gly-Asp-Ser (RGDS) peptide increased aggrecan expression, and decreased versican expression by TGF-beta1 stimulation.	Serine	125-128	fibronectin 1	Mus musculus	80-91
21601613-5	2011	Histological changes and increased amounts of fibronectin were observed in the lungs of OVA-immunized, 50-ppm-toluene-exposed mice.	Toluene	110-117	fibronectin 1	Mus musculus	46-57
21937717-6	2011	Adhesion to fibronectin stimulates tyrosine phosphorylation of the EGFR in the absence of receptor ligands.	Tyrosine	35-43	fibronectin 1	Mus musculus	12-23
21367916-9	2011	These findings were related to improved mesangial expansion and to fibronectin and transforming growth factor-beta1 production in response to ANG II and suggest that ANG-(1-7) may attenuate ANG II-stimulated ROS-mediated injury in type 2 diabetic nephropathy.	ros	208-211	fibronectin 1	Mus musculus	67-78
21464039-7	2011	Inhibition of MDA-MB-231 xenograft growth in vivo in female athymic mice by BITC administration was associated with an increase in protein level of E-cadherin and suppression of vimentin and fibronectin protein expression.	benzyl isothiocyanate	76-80	fibronectin 1	Mus musculus	191-202
21506116-6	2011	Inhibition of p38 MAPK blocked high glucose-induced Cav-1 and fibronectin (FN) expression.	Glucose	36-43	fibronectin 1	Mus musculus	62-73
21506116-6	2011	Inhibition of p38 MAPK blocked high glucose-induced Cav-1 and fibronectin (FN) expression.	Glucose	36-43	fibronectin 1	Mus musculus	75-77
21493703-0	2011	Immunization of apoE-/- mice with aldehyde-modified fibronectin inhibits the development of atherosclerosis.	Aldehydes	34-42	fibronectin 1	Mus musculus	52-63
20682584-5	2011	All particle-ligand complexes stimulated the release of nitric oxide, but only beads coated with IgG, complement factors or FN caused production of superoxide.	Superoxides	148-158	fibronectin 1	Mus musculus	124-126
21613227-9	2011	Finally, miR-21 enhanced high glucose-induced TORC1 activity, resulting in renal cell hypertrophy and fibronectin expression.	Glucose	30-37	fibronectin 1	Mus musculus	102-113
21360520-0	2011	Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4.	Leukotrienes	37-48	fibronectin 1	Mus musculus	18-29
21129455-2	2011	Our data showed that CA and CS reduced the expression of IL-1beta and TNF-alpha but had less effect on fibronectin and ICAM-1 expression.	carnosol	28-30	fibronectin 1	Mus musculus	103-114
21641382-8	2011	LSKL treatment reduced urinary TGF-beta activity and renal phospho-Smad2/3 levels and improved markers of tubulointerstitial injury (fibronectin) and podocytes (nephrin).	LSKL, Inhibitor of Thrombospondin (TSP-1)	0-4	fibronectin 1	Mus musculus	133-144
20945375-5	2011	Interestingly, ginsan treatment either before or after TGF-beta administration led to significant reductions in all of alpha-SMA, collagen-1, and fibronectin expression levels.	ginsan	15-21	fibronectin 1	Mus musculus	146-157
21617121-4	2011	In a mouse model of obstructive nephropathy, administration of a single dose of suramin immediately after ureteral obstruction abolished the expression of fibronectin, largely suppressed expression of alpha-SMA and type I collagen, and reduced the deposition of extracellular matrix proteins.	Suramin	80-87	fibronectin 1	Mus musculus	155-166
21276770-0	2011	Induction of integrin beta3 in PGE2-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin.	Dinoprostone	31-35	fibronectin 1	Mus musculus	123-134
21276770-0	2011	Induction of integrin beta3 in PGE2-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin.	Arginine	90-93	fibronectin 1	Mus musculus	123-134
21276770-0	2011	Induction of integrin beta3 in PGE2-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin.	Glycine	94-97	fibronectin 1	Mus musculus	123-134
21276770-0	2011	Induction of integrin beta3 in PGE2-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin.	Aspartic Acid	98-101	fibronectin 1	Mus musculus	123-134
21071958-6	2011	RESULTS: Correction of renal function in ZDF by pioglitazone, occurring with a glycemia &gt;250 mg/dl, was accompanied by normalization of the renal levels of connective tissue growth factor and fibronectin (fibrosis), TNF-alpha, interleukin-6 and MCP-1 (inflammation), megalin (tubular cells), the PCNA/caspase-3 ratio (positive cell turnover), VEGF (abnormal angiogenesis), and the ratio between eNOS and iNOS (endothelial dysfunction).	Pioglitazone	48-60	fibronectin 1	Mus musculus	195-206
21389693-7	2011	RESULTS: In the glomeruli of diabetic mice, treatment with tBHQ significantly reduced the levels of serum and glomerular MDA, kidney weight and proteinuria, decreased fibronectin accumulation and mitigated the pathogenic processes.	2-tert-butylhydroquinone	59-63	fibronectin 1	Mus musculus	167-178
20658539-6	2011	In addition, FN increased RhoA and Rho kinase activation, which were completely blocked by PP2, FAK small interfering RNA (siRNA), caveolin-1 siRNA, or the caveolar disruptor methyl-beta-cyclodextrin (MbetaCD).	methyl-beta-cyclodextrin	175-199	fibronectin 1	Mus musculus	13-15
20658539-6	2011	In addition, FN increased RhoA and Rho kinase activation, which were completely blocked by PP2, FAK small interfering RNA (siRNA), caveolin-1 siRNA, or the caveolar disruptor methyl-beta-cyclodextrin (MbetaCD).	methyl-beta-cyclodextrin	201-208	fibronectin 1	Mus musculus	13-15
20658539-7	2011	FN also increased phosphorylation of Akt and ERK 1/2, which were significantly blocked by either FAK siRNA, caveolin-1 siRNA, MbetaCD, GGTI-286 (RhoA inhibitor), or Y-27632 (Rho kinase inhibitor).	methyl-beta-cyclodextrin	126-133	fibronectin 1	Mus musculus	0-2
20658539-7	2011	FN also increased phosphorylation of Akt and ERK 1/2, which were significantly blocked by either FAK siRNA, caveolin-1 siRNA, MbetaCD, GGTI-286 (RhoA inhibitor), or Y-27632 (Rho kinase inhibitor).	GGTI 286	135-143	fibronectin 1	Mus musculus	0-2
20658539-7	2011	FN also increased phosphorylation of Akt and ERK 1/2, which were significantly blocked by either FAK siRNA, caveolin-1 siRNA, MbetaCD, GGTI-286 (RhoA inhibitor), or Y-27632 (Rho kinase inhibitor).	Y 27632	165-172	fibronectin 1	Mus musculus	0-2
21047552-2	2011	Reactive oxygen species (ROS) are major initiators of excessive collagen and fibronectin deposition in cardiac fibrosis.	Reactive Oxygen Species	0-23	fibronectin 1	Mus musculus	77-88
21047552-2	2011	Reactive oxygen species (ROS) are major initiators of excessive collagen and fibronectin deposition in cardiac fibrosis.	Reactive Oxygen Species	25-28	fibronectin 1	Mus musculus	77-88
20674665-1	2011	BACKGROUND: Our previous studies demonstrated that berberine could improve the renal function in rats and mice with diabetic nephropathy (DN) and inhibit extracellular matrix (ECM) component, fibronectin (FN) expression in rat mesangial cells (MCs) cultured under high glucose.	Berberine	51-60	fibronectin 1	Mus musculus	192-203
20674665-1	2011	BACKGROUND: Our previous studies demonstrated that berberine could improve the renal function in rats and mice with diabetic nephropathy (DN) and inhibit extracellular matrix (ECM) component, fibronectin (FN) expression in rat mesangial cells (MCs) cultured under high glucose.	Berberine	51-60	fibronectin 1	Mus musculus	205-207
21792478-5	2011	Hydroxyproline assay and Western blot showed that DOCA-salt treatment increased collagen content (mug/mg dry tissue) and fibronectin protein expression (%beta-actin arbitrary units) in the kidney of TRPV1-/- compared with WT mice (26.7 +- 2.7 versus 17.4 +- 1.8; 0.93 +- 0.07 versus 0.65 +- 0.08, P &lt; 0.05).	Desoxycorticosterone Acetate	50-54	fibronectin 1	Mus musculus	121-132
21792478-5	2011	Hydroxyproline assay and Western blot showed that DOCA-salt treatment increased collagen content (mug/mg dry tissue) and fibronectin protein expression (%beta-actin arbitrary units) in the kidney of TRPV1-/- compared with WT mice (26.7 +- 2.7 versus 17.4 +- 1.8; 0.93 +- 0.07 versus 0.65 +- 0.08, P &lt; 0.05).	Salts	55-59	fibronectin 1	Mus musculus	121-132
22140539-4	2011	We therefore examined the effects of the absence of fibronectin on the development of fibrosis in mice.Conditional deletion of fibronectin in the liver using the Mx promoter to drive cre expression resulted in increased collagen production and hence a more pronounced fibrosis in response to dimethylnitrosamine in mice.	Dimethylnitrosamine	292-311	fibronectin 1	Mus musculus	127-138
22140539-7	2011	Interfering with TGF-beta signaling using SB431542 normalized collagen-type-I production in fibronectin-deficient hepatic stellate cells.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	42-50	fibronectin 1	Mus musculus	92-103
21799763-1	2011	The arginine-glycine-aspartate (RGD) motif in fibronectin (FN) represents the major binding site for alpha5beta1 and alphavbeta3 integrins.	arginine-glycine-aspartate	4-30	fibronectin 1	Mus musculus	46-57
21799763-1	2011	The arginine-glycine-aspartate (RGD) motif in fibronectin (FN) represents the major binding site for alpha5beta1 and alphavbeta3 integrins.	arginine-glycine-aspartate	4-30	fibronectin 1	Mus musculus	59-61
20630933-9	2010	High d-glucose, but not l-glucose, stimulated phosphorylation of p38MAP kinase and increased expression of TGF-beta1/2 and fibronectin, effects that were inhibited by SB-203580 (p38MAP kinase inhibitor).	Glucose	5-14	fibronectin 1	Mus musculus	107-134
20658539-9	2011	Furthermore, inhibition of each pathway such as integrin beta1, Src, FAK, caveolin-1, RhoA, Akt, and ERK 1/2 blocked FN-induced [(3)H]-thymidine incorporation.	Thymidine	135-144	fibronectin 1	Mus musculus	117-119
20672308-0	2010	Fibronectin inhibits osteoclastogenesis while enhancing osteoclast activity via nitric oxide and interleukin-1beta-mediated signaling pathways.	Nitric Oxide	80-92	fibronectin 1	Mus musculus	0-11
20630933-9	2010	High d-glucose, but not l-glucose, stimulated phosphorylation of p38MAP kinase and increased expression of TGF-beta1/2 and fibronectin, effects that were inhibited by SB-203580 (p38MAP kinase inhibitor).	SB 203580	167-176	fibronectin 1	Mus musculus	107-134
20547151-3	2010	We have isolated a different form of soluble FN from mouse breast cancer cell line SC115 conditioned medium (CM) and purified it to homogeneity as evidenced by both native polyacrylamide gel electrophoresis (PAGE) and sodium dodecyl sulfate PAGE.	polyacrylamide	172-186	fibronectin 1	Mus musculus	45-47
20478370-12	2010	Lastly the EMT markers Twist, fibronectin and collagen I, but not alpha-smooth muscle actin, were also upregulated, suggesting that Cd-induced changes of renal epithelial tissue characteristics towards fibrosis and cancer may be mediated by Wnt signaling.	Cadmium	132-134	fibronectin 1	Mus musculus	30-41
20547151-3	2010	We have isolated a different form of soluble FN from mouse breast cancer cell line SC115 conditioned medium (CM) and purified it to homogeneity as evidenced by both native polyacrylamide gel electrophoresis (PAGE) and sodium dodecyl sulfate PAGE.	Sodium Dodecyl Sulfate	218-240	fibronectin 1	Mus musculus	45-47
20547151-5	2010	This form of FN is a potent cell adhesion factor (AF) that induces adhesion to polystyrene, elongation, spreading, alignment or "track" formation, and migration of mouse erythroleukemia cells.	Polystyrenes	79-90	fibronectin 1	Mus musculus	13-15
20547151-9	2010	However, this form of FN differs from other forms as it does not bind tightly to either gelatin or heparin.	Heparin	99-106	fibronectin 1	Mus musculus	22-24
20580428-2	2010	Single or multi-component proteins-bound SLBs were fabricated by conjugating type I collagen and/or fibronectin on the N-hydroxysulfosuccinimide-functionalized SLBs.	N-hydroxysulfosuccinimide	119-144	fibronectin 1	Mus musculus	100-111
20483351-4	2010	CS inhibited S100b-induced TGF-beta1 and fibronectin expression in mouse mesangial cells by suppressing activation of Smad2/3, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK), and oxidative stress.	Cesium	0-2	fibronectin 1	Mus musculus	41-52
20610874-5	2010	On the other hand, exogenously added fluorescein-labeled CS-E directory bound to fibronectin and RAW264 cells.	Fluorescein	37-48	fibronectin 1	Mus musculus	81-92
20872348-5	2010	METHODS: Microcontact printing of fibronectin stripes (10, 25, 50 mum in width) was performed onto biodegradable L-lactide/trimethylene carbonate copolymer (PLLA-TMC) films.	l-lactide/trimethylene carbonate copolymer	113-155	fibronectin 1	Mus musculus	34-45
20872348-5	2010	METHODS: Microcontact printing of fibronectin stripes (10, 25, 50 mum in width) was performed onto biodegradable L-lactide/trimethylene carbonate copolymer (PLLA-TMC) films.	plla-tmc	157-165	fibronectin 1	Mus musculus	34-45
20872348-7	2010	RESULTS: This approach proved to be simple, reliable and effective in obtaining a stable pattern of fibronectin on the PLLA-TMC surface as observed by fluorescence microscopy.	trimethylchlorosilane	124-127	fibronectin 1	Mus musculus	100-111
20472666-6	2010	In understanding the underlying mechanisms, we found that celastrol activated p38 mitogen-activated protein kinase (MAPK) by phosphorylation before the decrement of phosphorylated FAK and that this action was independent of the presence of fibronectin.	celastrol	58-67	fibronectin 1	Mus musculus	240-251
20164378-8	2010	TSP1 is responsible for the increased TGF-beta bioactivity under high glucose conditions, because treatment with anti-TSP1 antibody, small interfering RNA-TSP1, or an inhibitory peptide blocked glucose-mediated increases in TGF-beta activity and extracellular matrix protein (fibronectin) expression.	Glucose	194-201	fibronectin 1	Mus musculus	276-287
20481565-2	2010	In this study, a CLT1 peptide targeted G3 nanoglobular Mn(II)-DOTA monoamide conjugate was designed and synthesized as a targeted MRI contrast agent for molecular imaging of the fibrin-fibronectin complexes or oncofetal fibronectin in tumor stroma.	mn(ii)-dota monoamide	55-76	fibronectin 1	Mus musculus	185-196
20481565-2	2010	In this study, a CLT1 peptide targeted G3 nanoglobular Mn(II)-DOTA monoamide conjugate was designed and synthesized as a targeted MRI contrast agent for molecular imaging of the fibrin-fibronectin complexes or oncofetal fibronectin in tumor stroma.	mn(ii)-dota monoamide	55-76	fibronectin 1	Mus musculus	220-231
20219823-9	2010	Furthermore, the Omi inhibitor significantly attenuated UUO-induced increases in fibrotic characteristics in the kidney, including the atrophy and dilation of tubules, expansion of the interstitium, and increases in the expression of collagens, alpha-smooth muscle actin, and fibronectin.	uuo	56-59	fibronectin 1	Mus musculus	276-287
20447389-10	2010	The protein levels of intercellular adhesion molecule-1, transforming growth factor-beta 1 and fibronectin were all downregulated by berberine compared with diabetic model group.	Berberine	133-142	fibronectin 1	Mus musculus	95-106
20442405-10	2010	Within immortalized MEFs, FAK activity was required for fibronectin-stimulated FAK-p190RhoGAP association and p190RhoGAP tyrosine phosphorylation linked to decreased RhoA GTPase activity, focal adhesion turnover, and directional motility.	Tyrosine	121-129	fibronectin 1	Mus musculus	56-67
20409696-0	2010	Molecular assembly and biological activity of a recombinant fragment of fibronectin (FNIII(7-10)) on poly(ethyl acrylate).	poly(ethylacrylate)	101-121	fibronectin 1	Mus musculus	72-83
20200098-5	2010	In contrast, IMCD treated with Aldo exhibited a marked increase in the expression of collagen, fibronectin, and connective tissue growth factor (CTGF), whereas corticosterone alone had no effect.	imcd	13-17	fibronectin 1	Mus musculus	95-106
20200098-5	2010	In contrast, IMCD treated with Aldo exhibited a marked increase in the expression of collagen, fibronectin, and connective tissue growth factor (CTGF), whereas corticosterone alone had no effect.	Aldosterone	31-35	fibronectin 1	Mus musculus	95-106
20200098-6	2010	The Aldo-induced overexperession of collagen, fibronectin, and CTGF was substantially attenuated by the MR antagonist RU-318 and by the 11beta-HSD end product 11-dehydrocorticosterone, but not by the glucocorticoid receptor antagonist RU-486.	ru-318	118-124	fibronectin 1	Mus musculus	46-57
20200098-7	2010	In vivo, early fibrotic changes with elevated collagen, fibronectin, and CTGF expression were observed in kidneys isolated from normotensive adrenalectomized mice receiving a continuous infusion of Aldo (8 mug kg(-1) day(-1)) for 1 wk.	Aldosterone	198-202	fibronectin 1	Mus musculus	56-67
20112290-0	2010	Fibronectin synthesis by high glucose level mediated proliferation of mouse embryonic stem cells: Involvement of ANG II and TGF-beta1.	Glucose	30-37	fibronectin 1	Mus musculus	0-11
20375066-7	2010	Studies with fragments indicated that both the RGD-synergy site and the adjacent heparin-binding region of fibronectin were required for full activity in mechanotransduction, but not its ability to self-assemble.	Heparin	81-88	fibronectin 1	Mus musculus	107-118
20112290-4	2010	In addition, high glucose and ANG II synergistically increased FN expression level, which coincident with data showing that high glucose increased the mRNA expression of angiotensin II (ANG II) type 1 receptor (AT(1)R), angiotensinogen, and FN, but not ANG II type 2 receptor.	Glucose	129-136	fibronectin 1	Mus musculus	63-65
20112290-3	2010	Treatment of the two ES cells (ES-E14TG2a and ES-R1) with 25 mM glucose (high glucose) increased the expression levels of FN mRNA and protein.	Glucose	64-71	fibronectin 1	Mus musculus	122-124
20112290-4	2010	In addition, high glucose and ANG II synergistically increased FN expression level, which coincident with data showing that high glucose increased the mRNA expression of angiotensin II (ANG II) type 1 receptor (AT(1)R), angiotensinogen, and FN, but not ANG II type 2 receptor.	Glucose	129-136	fibronectin 1	Mus musculus	241-243
20112290-3	2010	Treatment of the two ES cells (ES-E14TG2a and ES-R1) with 25 mM glucose (high glucose) increased the expression levels of FN mRNA and protein.	Glucose	78-85	fibronectin 1	Mus musculus	122-124
20112290-6	2010	Inhibition of the Ca(2+)/PKC pathway blocked high glucose-induced FN expression.	Glucose	50-57	fibronectin 1	Mus musculus	66-68
20112290-4	2010	In addition, high glucose and ANG II synergistically increased FN expression level, which coincident with data showing that high glucose increased the mRNA expression of angiotensin II (ANG II) type 1 receptor (AT(1)R), angiotensinogen, and FN, but not ANG II type 2 receptor.	Glucose	18-25	fibronectin 1	Mus musculus	63-65
20112290-8	2010	Moreover, TGF-beta(1)-specific small interfering RNA inhibited high glucose-induced FN expression and c-Jun N-terminal kinase (JNK) activation.	Glucose	68-75	fibronectin 1	Mus musculus	84-86
20112290-4	2010	In addition, high glucose and ANG II synergistically increased FN expression level, which coincident with data showing that high glucose increased the mRNA expression of angiotensin II (ANG II) type 1 receptor (AT(1)R), angiotensinogen, and FN, but not ANG II type 2 receptor.	Glucose	18-25	fibronectin 1	Mus musculus	241-243
20304648-3	2010	Glatiramer acetate treatment was associated with significantly increased expression of regeneration transcription factors MyoD and myogenin, and attenuation of the fibrosis markers vimentin and fibronectin.	Glatiramer Acetate	0-18	fibronectin 1	Mus musculus	194-205
20821823-10	2010	Similarly, ETH exhibited significant suppression of IL-1beta, TNF-alpha, TGF-beta1 and fibronectin when cultured with BV.	eth	11-14	fibronectin 1	Mus musculus	87-98
20034663-4	2010	C3H10T1/2 cells were grown on type I collagen- or fibronectin-coated polyacrylamide hydrogels with tunable mechanical properties.	polyacrylamide	69-83	fibronectin 1	Mus musculus	50-61
19948213-4	2010	Functionally, we found that lymphocyte migration triggered by laminin or fibronectin was enhanced in cells from GH-Tg versus control mice, independent of the organ from which the cells were derived (as ascertained in young adult animals).	gh-tg	112-117	fibronectin 1	Mus musculus	73-84
20179298-7	2010	Finally, long-term celecoxib treatment induced tissue fibrosis, as indicated by increased expression of collagen, fibronectin, and laminin in the basement membrane.	Celecoxib	19-28	fibronectin 1	Mus musculus	114-125
20440757-7	2010	Residual particle-extracellular fibronectin matrix binding and 2 degrees transfer can be competitively disrupted by heparin exposure without affecting murine progenitor homing and repopulation.	Heparin	116-123	fibronectin 1	Mus musculus	32-43
20299795-0	2010	Pentoxifylline inhibits integrin-mediated adherence of 12(S)-HETE and TNFalpha-activated B16F10 cells to fibronectin and endothelial cells.	Pentoxifylline	0-14	fibronectin 1	Mus musculus	105-116
19640900-3	2009	alpha-Smooth muscle actin (alpha-SMA) and fibronectin, two hallmarks of fibroblast activation, were highly expressed in cultured NRK-49F cells, and their expression was inhibited in the presence of TSA.	trichostatin A	198-201	fibronectin 1	Mus musculus	42-53
19904222-6	2010	RESULTS: Cerulein administration to nontransgenic mice produced histological evidence of inflammatory infiltrate, glandular atrophy, and parenchymal fibrosis and increased collagen production, MPO activity, and collagen I and fibronectin mRNA levels.	Ceruletide	9-17	fibronectin 1	Mus musculus	211-237
19759524-4	2009	Compared to vehicle-treated controls, monotherapy with paricalcitol or trandolapril inhibited the expression and accumulation of fibronectin and type I and type III collagen, suppressed alpha-smooth muscle actin, vimentin, and Snail1 expression, and reduced total collagen content in the obstructed kidney.	paricalcitol	55-67	fibronectin 1	Mus musculus	129-140
19759524-4	2009	Compared to vehicle-treated controls, monotherapy with paricalcitol or trandolapril inhibited the expression and accumulation of fibronectin and type I and type III collagen, suppressed alpha-smooth muscle actin, vimentin, and Snail1 expression, and reduced total collagen content in the obstructed kidney.	trandolapril	71-83	fibronectin 1	Mus musculus	129-140
20223119-0	2009	[Recombinant polypeptide of N-terminal heparin-binding domain of fibronectin antagonizes hepatic failure induced by endotoxin in mice].	Heparin	39-46	fibronectin 1	Mus musculus	65-76
20223119-1	2009	OBJECTIVE: To study the preventive effect of recombinant polypeptide of N-terminal heparin-binding domain of fibronectin on hepatic failure induced by endotoxin in mice.	Heparin	83-90	fibronectin 1	Mus musculus	109-120
19654560-8	2009	Aldosterone induced stiffening of resistance arteries among all treated animals, as reflected by decreased sum of squares of strain from 2.07 +/- 0.15 to 1.54 +/- 0.29 in wild type, and from 2.68 +/- 0.28 to 2.04 +/- 0.15 in Op/+, and increased fibronectin-to-elastin ratio from 1.12 +/- 0.40 to 4.52 +/- 0.47 and 0.92 +/- 0.47 to 5.26 +/- 0.88, respectively.	Aldosterone	0-11	fibronectin 1	Mus musculus	245-256
19008864-7	2009	Expression of alpha8 integrin and its ligands fibronectin and osteopontin was increased in the hearts of DOCA-treated wild types compared to salt-loaded controls.	Desoxycorticosterone Acetate	105-109	fibronectin 1	Mus musculus	46-57
19151387-5	2009	METHODS: Fibronectin was purified from murine serum by gelatin cross-linked agarose chromatography and subsequently was enzymatically digested with alpha-chymotrypsin.	Sepharose	76-83	fibronectin 1	Mus musculus	9-20
19276073-5	2009	When MMP-2 activity was inhibited either by the metalloproteinase inhibitor GM-6001 or in MMP-2-deficient fibroblasts, an increase in the basal amount of FN together with a decrease of its levels in response to CTGF was observed.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	76-83	fibronectin 1	Mus musculus	154-156
20799170-0	2009	The role of fibronectin in cell adhesion to spiral patterned TiO2 nanoparticles.	titanium dioxide	61-65	fibronectin 1	Mus musculus	12-23
20799170-6	2009	The role of fibronectin to mediate cell adhesion to the TiO2 pattern surfaces was evaluated by experiments with blocked fibronectin membrane receptors on both HCAEC and NIH3T3.	titanium dioxide	56-60	fibronectin 1	Mus musculus	12-23
20799170-6	2009	The role of fibronectin to mediate cell adhesion to the TiO2 pattern surfaces was evaluated by experiments with blocked fibronectin membrane receptors on both HCAEC and NIH3T3.	titanium dioxide	56-60	fibronectin 1	Mus musculus	120-131
20799170-8	2009	Therefore, fibronectin seemed to be the only key protein in mediating cell adhesion to these TiO2 substrates.	titanium dioxide	93-97	fibronectin 1	Mus musculus	11-22
19477508-7	2009	Immunohistochemistry of fibers incorporated with MC-3T3 ECM reveal the presence of the ECM components, collagen type I, collagen type IV, fibronectin and heparan sulfate, on their surface.	Methylcholanthrene	49-51	fibronectin 1	Mus musculus	138-149
18987023-6	2009	Furthermore, MC3T3-E1 cells on chitosan/poly-L-lysine membrane exhibit increased phosphorylation levels of focal adhesion kinase and extracellular signal-regulated kinase 1/2, and achieve an enhanced mRNA expression of fibronectin, Runx 2, RhoA, integrin alpha 5, and integrin beta1.	Lysine	40-53	fibronectin 1	Mus musculus	219-230
19375650-7	2009	RESULTS: Combined treatment of AS101 with melphalan in vitro resulted in a synergistic inhibitory effect on growth, G(2)/M phase growth arrest, reduced IgG(2b) secretion, apoptotic cell death, and reduced fibronectin-mediated adhesion of MM cells.	ammonium trichloro(dioxoethylene-O,O'-)tellurate	31-36	fibronectin 1	Mus musculus	205-216
19375650-7	2009	RESULTS: Combined treatment of AS101 with melphalan in vitro resulted in a synergistic inhibitory effect on growth, G(2)/M phase growth arrest, reduced IgG(2b) secretion, apoptotic cell death, and reduced fibronectin-mediated adhesion of MM cells.	Melphalan	42-51	fibronectin 1	Mus musculus	205-216
19285555-1	2009	Fibronectin (FN) matrix fibrils have long been thought to be formed by disulfide-bonded FN multimers, although there is no direct evidence that they are covalently linked with each other.	Disulfides	71-80	fibronectin 1	Mus musculus	0-11
19285555-1	2009	Fibronectin (FN) matrix fibrils have long been thought to be formed by disulfide-bonded FN multimers, although there is no direct evidence that they are covalently linked with each other.	Disulfides	71-80	fibronectin 1	Mus musculus	13-15
19285555-1	2009	Fibronectin (FN) matrix fibrils have long been thought to be formed by disulfide-bonded FN multimers, although there is no direct evidence that they are covalently linked with each other.	Disulfides	71-80	fibronectin 1	Mus musculus	88-90
19285555-3	2009	The insoluble extracted matrix preserved fibrillar structures and a major portion of the extracted proteins migrated as FN monomers on an SDS gel under reducing conditions.	Sodium Dodecyl Sulfate	138-141	fibronectin 1	Mus musculus	120-122
19285555-5	2009	We tested this by mixing fluorescently labeled FN dimers with the extracted matrix just before loading on an SDS gel, and found that most of them were trapped with the extracted proteins at the top of the stacking gel.	Sodium Dodecyl Sulfate	109-112	fibronectin 1	Mus musculus	47-49
19285555-10	2009	The phenomenon by which FN molecules appear to migrate as multimers on SDS gels is thus an artifact rising from the presence of other large components in the extract.	Sodium Dodecyl Sulfate	71-74	fibronectin 1	Mus musculus	24-26
19093139-4	2009	In this study we compared the inhibitory effects of MPA and IMPDH2 reduction [by using small interfering RNA (siRNA)] on oleic acid (OA)-induced fibronectin secretion and cellular reactive oxygen species (ROS) in mouse MCs.	Oleic Acid	121-131	fibronectin 1	Mus musculus	145-156
19093139-4	2009	In this study we compared the inhibitory effects of MPA and IMPDH2 reduction [by using small interfering RNA (siRNA)] on oleic acid (OA)-induced fibronectin secretion and cellular reactive oxygen species (ROS) in mouse MCs.	Oleic Acid	133-135	fibronectin 1	Mus musculus	145-156
19093139-6	2009	Fibronectin secretion into the medium was examined by Western blot, dichlorodihydrofluorescein (DCF)-sensitive cellular ROS by fluorescence-activated cell scanning (FACS), TGF-beta levels in the media by enzyme-linked immunosorbent assay (ELISA).	dichlorodihydrofluorescein	68-94	fibronectin 1	Mus musculus	0-11
19093139-9	2009	NAC and MPA completely suppressed OA-induced fibronectin secretion and decreased the levels of TGF-beta and cellular ROS.	Acetylcysteine	0-3	fibronectin 1	Mus musculus	45-56
19114027-6	2009	Halofuginone showed an inhibitory effect on type I collagen and fibronectin expression promoted by TGF-beta(1).	halofuginone	0-12	fibronectin 1	Mus musculus	64-75
19114027-7	2009	An in vivo experiment using db/db mice confirmed the ability of halofuginone to suppress mesangial expansion and fibronectin overexpression in the kidneys.	halofuginone	64-76	fibronectin 1	Mus musculus	113-124
19008864-7	2009	Expression of alpha8 integrin and its ligands fibronectin and osteopontin was increased in the hearts of DOCA-treated wild types compared to salt-loaded controls.	Salts	141-145	fibronectin 1	Mus musculus	46-57
19609076-10	2009	Also, p27 and fibronectin were increased in diabetics and attenuated by ibuprofen.	Ibuprofen	72-81	fibronectin 1	Mus musculus	14-25
19012271-5	2009	FN adsorption kinetics and monolayer coverage was determined on SAMs with or without Ca-P coating.	SAMS Peptide	64-68	fibronectin 1	Mus musculus	0-2
19012271-5	2009	FN adsorption kinetics and monolayer coverage was determined on SAMs with or without Ca-P coating.	calcium phosphate	85-89	fibronectin 1	Mus musculus	0-2
19012271-8	2009	We demonstrate that, although the FN monolayer coverage and the root mean square (rms) roughness are similar on --OH and --COOH terminated SAMs with or without Ca-P coating, higher levels of ALP activity, more actin cytoskeleton formation and more cell growth are obtained on --OH- and --COOH-terminated SAMs with Ca-P coating.	SAMS Peptide	139-143	fibronectin 1	Mus musculus	34-36
19012271-9	2009	In addition, although the FN monolayer coverage is higher on Ca-P-coated --NH(2)-terminated SAMs and SiO(x) surfaces, higher levels of ALP activity and more cell growth are obtained on Ca-P-coated --OH- and --COOH-terminated SAMs.	calcium phosphate	61-65	fibronectin 1	Mus musculus	26-28
19012271-9	2009	In addition, although the FN monolayer coverage is higher on Ca-P-coated --NH(2)-terminated SAMs and SiO(x) surfaces, higher levels of ALP activity and more cell growth are obtained on Ca-P-coated --OH- and --COOH-terminated SAMs.	--nh(2)	73-80	fibronectin 1	Mus musculus	26-28
19012271-9	2009	In addition, although the FN monolayer coverage is higher on Ca-P-coated --NH(2)-terminated SAMs and SiO(x) surfaces, higher levels of ALP activity and more cell growth are obtained on Ca-P-coated --OH- and --COOH-terminated SAMs.	SAMS Peptide	92-96	fibronectin 1	Mus musculus	26-28
18945941-6	2008	Retinal EC under high-glucose conditions also expressed increased levels of fibronectin, osteopontin, and alpha(v)beta(3)-integrin, and reduced levels of thrombospondin-1.	Glucose	22-29	fibronectin 1	Mus musculus	76-87
18667486-7	2008	Podocyte loss and glomerular fibronectin accumulation, other markers of early DN, were prevented by rosiglitazone in both 12- and 24-wk diabetic models.	Rosiglitazone	100-113	fibronectin 1	Mus musculus	29-40
18701453-1	2008	High glucose (30 mM) and high insulin (1 nM), pathogenic factors of type 2 diabetes, increased mRNA expression and synthesis of lamininbeta1 and fibronectin after 24 h of incubation in kidney proximal tubular epithelial (MCT) cells.	Glucose	5-12	fibronectin 1	Mus musculus	145-156
18674534-11	2008	As well, heparin counteracted the known inhibitory effect of fibronectin on adipogenesis and decreased basal focal adhesion kinase and paxillin phosphorylation.	Heparin	9-16	fibronectin 1	Mus musculus	61-72
18701508-6	2008	Metastasis to distant organs was decreased in silibinin-fed mice, which was associated with a decreased expression of matrix metalloproteinases, mesenchymal markers snail-1, and fibronectin in the prostatic tissue and retention of epithelial characteristics.	Silybin	46-55	fibronectin 1	Mus musculus	178-189
18453543-3	2008	We show here that Abi1 gene silencing by short hairpin RNA attenuated the Bcr-Abl-induced abnormal actin remodeling, membrane-type 1 metalloproteinase clustering and inhibited cell adhesion and migration on fibronectin-coated surfaces.	lauric acid	78-81	fibronectin 1	Mus musculus	207-218
18972793-0	2008	Gene expression monitoring in osteoblasts on titanium coated with fibronectin-derived peptide.	Titanium	45-53	fibronectin 1	Mus musculus	66-77
18695906-4	2008	Treatment with non-cytotoxic concentrations of SeMet (2.5, 5 and 10 microM plus 0.02 U/ml METase, methioninase) induced a substantial decrease in the expression of integrin alphavbeta3, the FN receptor and adhesion ability to vitronectin (VN) and fibronectin (FN) in B16F10 melanoma cells.	Selenomethionine	47-52	fibronectin 1	Mus musculus	247-258
18507410-3	2008	The approach immobilizes the fibronectin-derived cell adhesion ligand Arg-Gly-Asp-Ser-Pro (RGDSP) using carbodiimide activation chemistry and immobilizes DNA strands on the same surface via cDNA-DNA interactions.	Arginine	70-73	fibronectin 1	Mus musculus	29-40
18485469-1	2008	Chitosan scaffolds were prepared by freeze-drying method and modified with Arg-Gly-Asp (RGD) sequence of fibronectin or epidermal growth factor (EGF) by covalent immobilization.	arginyl-glycyl-aspartic acid	75-86	fibronectin 1	Mus musculus	105-116
18507462-0	2008	Molecular recognition based on low-affinity polyvalent interactions: selective binding of a carboxylated polymer to fibronectin fibrils of live fibroblast cells.	Polymers	105-112	fibronectin 1	Mus musculus	116-127
18507410-3	2008	The approach immobilizes the fibronectin-derived cell adhesion ligand Arg-Gly-Asp-Ser-Pro (RGDSP) using carbodiimide activation chemistry and immobilizes DNA strands on the same surface via cDNA-DNA interactions.	gly-asp-ser-pro	74-89	fibronectin 1	Mus musculus	29-40
18507410-3	2008	The approach immobilizes the fibronectin-derived cell adhesion ligand Arg-Gly-Asp-Ser-Pro (RGDSP) using carbodiimide activation chemistry and immobilizes DNA strands on the same surface via cDNA-DNA interactions.	Carbodiimides	104-116	fibronectin 1	Mus musculus	29-40
18507410-5	2008	The fibronectin-derived cell adhesion ligand GGRGDSP was covalently linked to carboxylate groups on DNA-containing SAM substrates, and peptide density was proportional to the amount of carboxylate present during SAM preparation.	carboxylate	78-89	fibronectin 1	Mus musculus	4-15
18507410-5	2008	The fibronectin-derived cell adhesion ligand GGRGDSP was covalently linked to carboxylate groups on DNA-containing SAM substrates, and peptide density was proportional to the amount of carboxylate present during SAM preparation.	carboxylate	185-196	fibronectin 1	Mus musculus	4-15
18317125-10	2008	CONCLUSION: In vitro attachment and proliferation of bone-forming cells on hydroxyapatite is significantly increased by pretreatment with fibronectin/fetal calf serum, but this difference is less profound and not significant in vivo.	Durapatite	75-89	fibronectin 1	Mus musculus	138-149
18434887-11	2008	Polydeoxyribonucleotide improved healing of burn wound through increased epithelial proliferation and maturation of the extracellular matrix as confirmed by fibronectin and laminin immunostaining.	Polydeoxyribonucleotides	0-23	fibronectin 1	Mus musculus	157-168
18369319-3	2008	Interestingly, the GRK2 effect on fibronectin-mediated cell migration involves the paracrine/autocrine activation of a sphingosine-1-phosphate (S1P) Gi-coupled GPCR.	sphingosine 1-phosphate	119-142	fibronectin 1	Mus musculus	34-45
18374103-3	2008	To explore the importance of IMPDH2 on the inhibitory effects of MPA in mesangial cells (MC), we compared the effects of MPA and IMPDH2 siRNA on high glucose (HG)-induced fibronectin secretion and cellular reactive oxygen species (ROS).	Glucose	150-157	fibronectin 1	Mus musculus	171-182
18374103-9	2008	These results suggested that MPA may inhibit HG-induced fibronectin secretion partially through inhibiting cellular ROS and the inhibition of IMPDH2 may be partially involved in the mechanism of MPA.	Reactive Oxygen Species	116-119	fibronectin 1	Mus musculus	56-67
17991876-5	2008	Using a flow chamber and the ferric-chloride injury model we found that EDA+ FN accelerates thrombosis both in vitro and in vivo at arterial shear rates.	ferric chloride	29-44	fibronectin 1	Mus musculus	77-79
18392786-3	2008	Culture of MES-13 cells in medium containing supra-physiological glucose concentrations (&gt;5.5 mmol/l) resulted in increased production of ECM proteins including laminin, fibronectin, and heparan sulfate proteoglycan with concurrent increases in IGF-binding protein (IGFBP)-2 production.	2-(N-morpholino)ethanesulfonic acid	11-14	fibronectin 1	Mus musculus	173-184
18392786-3	2008	Culture of MES-13 cells in medium containing supra-physiological glucose concentrations (&gt;5.5 mmol/l) resulted in increased production of ECM proteins including laminin, fibronectin, and heparan sulfate proteoglycan with concurrent increases in IGF-binding protein (IGFBP)-2 production.	Glucose	65-72	fibronectin 1	Mus musculus	173-184
18317125-0	2008	Treatment of hydroxyapatite scaffolds with fibronectin and fetal calf serum increases osteoblast adhesion and proliferation in vitro.	Durapatite	13-27	fibronectin 1	Mus musculus	43-54
17968528-6	2008	In both non-diabetic and streptozotocin-induced diabetic mice that were deficient or not in MCP-1, glomerular fibronectin accumulation was examined by immunohistochemistry, while cortical Tgf-beta1 (also known as Tgfb1) and fibronectin mRNA and protein levels were examined by real-time PCR and western blotting.	Streptozocin	25-39	fibronectin 1	Mus musculus	110-121
17928826-6	2008	1,25-Dihydroxyvitmain D3 inhibited high glucose (HG)-induced FN production in cultured mesangial cells and increased nephrin expression in cultured podocytes.	1,25-dihydroxyvitmain d3	0-24	fibronectin 1	Mus musculus	61-63
17928826-6	2008	1,25-Dihydroxyvitmain D3 inhibited high glucose (HG)-induced FN production in cultured mesangial cells and increased nephrin expression in cultured podocytes.	Glucose	40-47	fibronectin 1	Mus musculus	61-63
17881772-8	2007	Fn1 expression was increased under the high-glucose condition, although hypoxia also increased Fn1 expression to a lesser degree.	Glucose	44-51	fibronectin 1	Mus musculus	0-3
17717067-8	2007	In the defined conditions, mES cells did not express collagen-binding integrin subunits, but they expressed laminin- and fibronectin-binding integrin subunits.	2-(N-morpholino)ethanesulfonic acid	27-30	fibronectin 1	Mus musculus	121-132
17644756-9	2007	Oxidant stress also increased the phosphorylation of cAMP response element binding protein, a transcription factor known for its ability to stimulate fibronectin expression, and increased the expression of mRNAs and proteins coding for the transcription factors nuclear factor (NF)-kappaB and mothers against decapentaplegic homolog 3.	Cyclic AMP	53-57	fibronectin 1	Mus musculus	150-161
17986856-4	2007	PTX brought about a significant reduction in the integrin mediated adhesion of F10 cells to Fibronectin and Vitronectin (58.75% +/- 3.4 S.E and 60% +/- 1.7 S.E respectively if control was considered as 100%).	Pentoxifylline	0-3	fibronectin 1	Mus musculus	92-103
17666488-8	2007	Galactose feeding caused significant upregulation of FN, EDB(+)FN, and TGF-beta in all tissues.	Galactose	0-9	fibronectin 1	Mus musculus	53-55
17883726-10	2007	However, CCR5 deficiency did not affect CS-induced airway wall remodelling, because chronic CS exposure induced a similar increase in airway wall thickness, smooth muscle mass and peribronchial deposition of collagen and fibronectin in both wild-type and CCR5 KO mice.	Cesium	92-94	fibronectin 1	Mus musculus	221-232
17521718-5	2007	Using plasma fibronectin (pFN) conditional knock-out mice, we demonstrate that pFN modulates the foreign body response to polyethylene terephthalate disks implanted subcutaneously.	Polyethylene Terephthalates	122-148	fibronectin 1	Mus musculus	13-24
17644756-11	2007	Furthermore, fibronectin expression in response to an oxidized E(h) Cys/CySS was associated with expression of transforming growth factor-beta1 (TGF-beta1) and was inhibited by an anti-TGF-beta1 antibody and SB-431542, a TGF-beta1 receptor inhibitor.	Cysteine	68-71	fibronectin 1	Mus musculus	13-24
17644756-11	2007	Furthermore, fibronectin expression in response to an oxidized E(h) Cys/CySS was associated with expression of transforming growth factor-beta1 (TGF-beta1) and was inhibited by an anti-TGF-beta1 antibody and SB-431542, a TGF-beta1 receptor inhibitor.	cyss	72-76	fibronectin 1	Mus musculus	13-24
17644756-11	2007	Furthermore, fibronectin expression in response to an oxidized E(h) Cys/CySS was associated with expression of transforming growth factor-beta1 (TGF-beta1) and was inhibited by an anti-TGF-beta1 antibody and SB-431542, a TGF-beta1 receptor inhibitor.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	208-217	fibronectin 1	Mus musculus	13-24
17643114-3	2007	In vitro studies demonstrate the role of CatL in the degradation of the matrix protein fibronectin, insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF-1R), essential molecules for adipogenesis and glucose metabolism.	Glucose	215-222	fibronectin 1	Mus musculus	87-98
18203463-0	2007	Gene expression of MC3T3-E1 cells on fibronectin-immobilized titanium using tresyl chloride activation technique.	Titanium	61-69	fibronectin 1	Mus musculus	37-48
18203463-0	2007	Gene expression of MC3T3-E1 cells on fibronectin-immobilized titanium using tresyl chloride activation technique.	2,2,2-trifluoroethanesulfonyl chloride	76-91	fibronectin 1	Mus musculus	37-48
18203463-1	2007	Fibronectin (FN) can be immobilized directly on titanium surfaces using tresyl chloride activation technique.	2,2,2-trifluoroethanesulfonyl chloride	72-87	fibronectin 1	Mus musculus	0-11
18203463-1	2007	Fibronectin (FN) can be immobilized directly on titanium surfaces using tresyl chloride activation technique.	2,2,2-trifluoroethanesulfonyl chloride	72-87	fibronectin 1	Mus musculus	13-15
18203463-3	2007	In this study, we examined the cell attachment and gene expression of MC3T3-E1 cells on FN-immobilized titanium using GeneChip.	Titanium	103-111	fibronectin 1	Mus musculus	88-90
18203463-7	2007	Taken together, the immobilization of FN on tresylated titanium promoted early matrix mineralization and bone formation.	Titanium	55-63	fibronectin 1	Mus musculus	38-40
17665426-7	2007	RESULTS: Reductions in the cytokine-induced transcription of Colalpha1(I) and fibronectin were observed in both normal and SSc skin fibroblasts following the addition of TSA.	trichostatin A	170-173	fibronectin 1	Mus musculus	78-89
17697986-1	2007	In this study, chitosan membranes prepared by the solvent casting method were modified with the Arg-Gly-Asp-Ser (RGDS) sequence of fibronectin using the photochemical immobilization technique.	arginyl-glycyl-aspartyl-serine	96-111	fibronectin 1	Mus musculus	131-142
17646041-9	2007	An overproduction of the interstitial matrix component fibronectin and the expression of the myofibroblasts/EMT marker alpha-SMA in kidneys of mice exposed to 100mg CdCl(2)/l clearly indicated that an exposure to relatively low Cd doses might lead ultimately to renal fibrosis.	cdcl	165-169	fibronectin 1	Mus musculus	55-66
17591922-1	2007	Fibronectin (FN) is secreted as a disulfide-bonded FN dimer.	Disulfides	34-43	fibronectin 1	Mus musculus	0-11
17591922-1	2007	Fibronectin (FN) is secreted as a disulfide-bonded FN dimer.	Disulfides	34-43	fibronectin 1	Mus musculus	13-15
17591922-1	2007	Fibronectin (FN) is secreted as a disulfide-bonded FN dimer.	Disulfides	34-43	fibronectin 1	Mus musculus	51-53
17591922-7	2007	Matrix assembly assays and solid-phase binding assays reveal that alphavbeta3 integrin assembles FN-RGE by binding an isoDGR motif in FN-I5, which is generated by the nonenzymatic rearrangement of asparagines (N) into an iso-aspartate (iso-D).	Asparagine	197-208	fibronectin 1	Mus musculus	97-99
17591922-7	2007	Matrix assembly assays and solid-phase binding assays reveal that alphavbeta3 integrin assembles FN-RGE by binding an isoDGR motif in FN-I5, which is generated by the nonenzymatic rearrangement of asparagines (N) into an iso-aspartate (iso-D).	Asparagine	197-208	fibronectin 1	Mus musculus	134-136
17574989-0	2007	Small-animal PET of tumor angiogenesis using a (76)Br-labeled human recombinant antibody fragment to the ED-B domain of fibronectin.	Bromine	51-53	fibronectin 1	Mus musculus	120-131
17456220-9	2007	The extravasation of plasma and fibronectin production in the lung, and collagen deposition in the lung were also inhibited after methysergide treatment.	Methysergide	130-142	fibronectin 1	Mus musculus	32-43
17350006-5	2007	Fibronectin processing can be inhibited by chloroquine, an inhibitor of lysosomal degradation, and can be enhanced by the overexpression of legumain, indicating that fibronectin degradation occurs in the presence of legumain in lysosomes from renal proximal tubular cells.	Chloroquine	43-54	fibronectin 1	Mus musculus	0-11
17280488-3	2007	We investigated in murine NIH3T3 fibroblasts the contribution of a variety of redox-dependent events during signal transduction initiated by integrin engagement due to fibronectin stimulation and report that a mitochondrial ROS release occurs, strictly confined to the early phase of extracellular matrix (ECM) contact (10 min).	Reactive Oxygen Species	224-227	fibronectin 1	Mus musculus	168-179
17456220-11	2007	In addition, instillation of serotonin to immunized mice induced eosinophil recruitment to BAL, Th2 cytokine production and fibronectin release in lung as well as collagen deposition.	Serotonin	29-38	fibronectin 1	Mus musculus	124-135
17215068-11	2007	On the other hand, the genes involved in the development of fibrosis, such as procollagen, Fn1, Eln, SMA, and Mmp9, Timp1 were significantly increased on day 5, not at 6h nor at 24h, after PQ treatment (the late marker).	Paraquat	189-191	fibronectin 1	Mus musculus	91-94
17210124-5	2007	In vitro macrophage migration assay showed a greater migration to renal tissue of control UUO kidney (day 14) than to TISAM-treated kidney, which was suppressed by preincubating macrophages with RGDS, a fibronectin degradation peptide.	tisam	118-123	fibronectin 1	Mus musculus	203-214
16846639-3	2006	The synthetic peptide YLEPVARGDGGLA-NH(2) (70 microM) inhibited the adhesion to fibronectin of B16F10 (high-metastatic B16 murine mouse melanoma cell line) and of Tm5 (murine melanoma cell lines derived from a non-tumorigenic lineage of pigmented murine melanocytes, melan-a).	ylepvargdggla-nh(2)	22-41	fibronectin 1	Mus musculus	80-91
17360953-9	2007	Immunohistochemistry of the kidneys from PKC-epsilon(-/-) mice showed increased renal fibronectin and collagen IV expression that was further aggravated in the streptozotocin-induced diabetic stress model.	Streptozocin	160-174	fibronectin 1	Mus musculus	86-97
17027741-3	2007	Pharmacological agents used to antagonize PLC (U73122) or the inositol phosphate receptor (Xestospongin C) inhibited FN-induced elevation of intracellular Ca(2+) and prevented the upregulation of FN-binding activity.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	47-53	fibronectin 1	Mus musculus	117-119
17027741-3	2007	Pharmacological agents used to antagonize PLC (U73122) or the inositol phosphate receptor (Xestospongin C) inhibited FN-induced elevation of intracellular Ca(2+) and prevented the upregulation of FN-binding activity.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	47-53	fibronectin 1	Mus musculus	196-198
17027741-5	2007	Inhibition of protein tyrosine kinase activity by genistein, but not G-protein inhibition by suramin, blocked FN-induced intracellular Ca(2+) signaling and upregulation of adhesion, consistent with involvement of PLC-gamma.	Genistein	50-59	fibronectin 1	Mus musculus	110-112
17027741-7	2007	Phosphotyrosine site-directed antibodies revealed phosphorylation of PLC-gamma2, but not PLC-gamma1, upon integrin ligation by FN.	Phosphotyrosine	0-15	fibronectin 1	Mus musculus	127-129
17027741-8	2007	These data suggest that integrin-mediated activation of PLC-gamma to initiate phosphoinositide signaling and intracellular Ca(2+) mobilization is required for blastocyst adhesion to FN.	Phosphatidylinositols	78-94	fibronectin 1	Mus musculus	182-184
16963618-9	2007	In vitro studies of endothelial cells treated with asymmetric dimethylarginine showed decreased expression of eNOS and Flk-1 and enhanced expression of calponin and fibronectin, additional markers of smooth muscle and mesenchymal cells.	dimethylarginine	62-78	fibronectin 1	Mus musculus	165-176
17237600-4	2007	We have previously shown that fibronectin-bound S. aureus is efficiently phagocytosed by thioglycolate-induced mouse peritoneal macrophages.	Thioglycolates	89-102	fibronectin 1	Mus musculus	30-41
17082242-4	2006	Compared with vehicle controls, paricalcitol significantly attenuated renal interstitial fibrosis in mouse kidney after ureteral obstruction, as demonstrated by a reduced interstitial volume, decreased collagen deposition, and repressed mRNA expression of fibronectin and type I and type III collagens.	paricalcitol	32-44	fibronectin 1	Mus musculus	256-267
17082242-7	2006	In vitro, paricalcitol abolished TGF-beta1-mediated E-cadherin suppression and alpha-smooth muscle actin and fibronectin induction in tubular epithelial cells, underscoring its ability to block directly the epithelial to mesenchymal transition (EMT).	paricalcitol	10-22	fibronectin 1	Mus musculus	109-120
17071578-6	2006	Moreover, the co-administration of SB203580 and ALK5I to ADR-injected mice resulted in a down-regulation of total and active TGF-beta1 production, reduced myofibroblast accumulation, and decreased expression of collagen type IV and fibronectin.	SB 203580	35-43	fibronectin 1	Mus musculus	232-243
16890932-4	2006	Treatment with a synthetic MMP inhibitor, GM6001, in utero enhanced the branching pattern in both wild type and null lungs accompanied by a restoration of fibronectin localization, signaling through FAK and epithelial cell proliferation in null lungs.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	42-48	fibronectin 1	Mus musculus	155-166
17260474-12	2006	The expressions of TGF-beta1, CTGF, and fibronectin in mice aged 20 weeks treated with rosiglitazone decreased by 37% , 21% , and 52% than same-aged control (P &lt;0.	Rosiglitazone	87-100	fibronectin 1	Mus musculus	40-51
17065349-8	2006	Examination of the heart tissues of streptozotocin-induced diabetic mice revealed increased fibronectin and p300 mRNA.	Streptozocin	36-50	fibronectin 1	Mus musculus	92-103
16806716-4	2006	Further, inhibition of oligosaccharides on the molecules like beta1 integrin (one of the major carriers) caused 30-45% reduction in their adherence to extra-cellular-matrix components especially collagen IV and laminin, and chemotaxis towards fibronectin and matrigel.	Oligosaccharides	23-39	fibronectin 1	Mus musculus	243-254
16988251-6	2006	The affinity for Fn was very high for both FL-ScpB (equilibrium dissociation constant [KD] = 4.0 nM) and Scp-PDF (KD = 4.4 nM) and is consistent with a biologically significant role for the adhesin activity of ScpB.	fl-scpb	43-50	fibronectin 1	Mus musculus	17-19
16988251-9	2006	The affinities of both FL-ScpBDelta (KD = 2.4 nM) and ScpBDelta-PDF (KD = 1.4 nM) for Fn are unaffected by the deletion.	fl-scpbdelta	23-35	fibronectin 1	Mus musculus	86-88
16988251-10	2006	Complementation in trans by both scpB and scpBDelta corrected the Fn-binding defect of an scpB deletion mutant GBS strain to an identical degree.	gbs	111-114	fibronectin 1	Mus musculus	66-68
17016179-8	2006	RESULTS: Fluoropolymer surface treatment with fibronectin improved the attachment of adipose-derived stem cells to the well plates but did not improve attachment to the fluoropolymer, regardless of pore size.	fluoropolymer	9-22	fibronectin 1	Mus musculus	46-57
16820793-10	2006	High glucose also led to enhanced production of fibronectin and collagen IV protein, which was blocked by 1,25-dihydroxyvitamin D3.	Glucose	5-12	fibronectin 1	Mus musculus	48-59
17022972-8	2006	Collectively, these results provide insights into the mechanism by which BMP signaling enhances cell migration by modulating fibronectin-integrin beta1 signaling via cholesterol enriched membrane microdomains, lipid rafts.	Cholesterol	166-177	fibronectin 1	Mus musculus	125-136
16820793-10	2006	High glucose also led to enhanced production of fibronectin and collagen IV protein, which was blocked by 1,25-dihydroxyvitamin D3.	Calcitriol	106-130	fibronectin 1	Mus musculus	48-59
16837927-4	2006	Methyl arachidonyl fluorophosphonate (MAFP), known as an inhibitor of group IVA PLA(2), markedly suppressed the oxLDL-induced production of fibronectin as well as the release of arachidonic acid, whereas it did not inhibit the production of collagen.	methyl arachidonylfluorophosphonate	0-36	fibronectin 1	Mus musculus	140-151
16678816-8	2006	We further demonstrated that Tam67 suppressed the expression of AP-1-dependent genes (TIMP-1, vimentin, Fra-1, and fibronectin) and the AP-1-dependent growth regulatory genes (cyclin D1 and c-myc) in AP-1-blocked mammary glands.	tam67	29-34	fibronectin 1	Mus musculus	115-126
16837927-4	2006	Methyl arachidonyl fluorophosphonate (MAFP), known as an inhibitor of group IVA PLA(2), markedly suppressed the oxLDL-induced production of fibronectin as well as the release of arachidonic acid, whereas it did not inhibit the production of collagen.	methyl arachidonylfluorophosphonate	38-42	fibronectin 1	Mus musculus	140-151
16837927-5	2006	The inhibitory effect of MAFP on the production of fibronectin was reversed by adding arachidonic acid and 12-hydroxyeicosatetraenoic acid.	Arachidonic Acid	86-102	fibronectin 1	Mus musculus	51-62
16837927-5	2006	The inhibitory effect of MAFP on the production of fibronectin was reversed by adding arachidonic acid and 12-hydroxyeicosatetraenoic acid.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	107-138	fibronectin 1	Mus musculus	51-62
16134174-9	2005	Compared to unmodified PHBHHx, fibronectin adsorption, and MC3T3-E1 cell attachment and proliferation were significantly greater on surface-hydrolyzed PHBHHx, which may be due to the increased surface free energy and rougher surface.	poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)	151-157	fibronectin 1	Mus musculus	31-42
16393968-11	2006	Dopamine selectively induced adhesion of naive CD8+ T cells to fibronectin and ICAM-1 through activation of integrins.	Dopamine	0-8	fibronectin 1	Mus musculus	63-74
16125745-11	2006	Corresponding to the reduced cleft sites in TCDD-exposed explants, FN immunoreactivity in the epithelium was reduced.	Polychlorinated Dibenzodioxins	44-48	fibronectin 1	Mus musculus	67-69
16368900-6	2006	In these conditions, NAMI-A reduces the gelatinase activity of tumor cells, and it also increases cell adhesion to poly-L-lysine and, in particular, to fibronectin, and this effect is associated to the increase of F-actin condensation.	imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III)	21-27	fibronectin 1	Mus musculus	152-163
16528256-10	2006	In PAI-1(-/-) mice, aldosterone increased renal expression of collagen I, osteopontin, fibronectin, and MCP-1, and tended to increase collagen III.	Aldosterone	20-31	fibronectin 1	Mus musculus	87-98
16369191-0	2006	Fibronectin prevents D-galactosamine/lipopolysaccharide-induced lethal hepatic failure in mice.	Galactosamine	21-36	fibronectin 1	Mus musculus	0-11
16369191-2	2006	In this study, we examined the effects of FN on D-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant liver failure in mice.	Galactosamine	48-63	fibronectin 1	Mus musculus	42-44
16369191-2	2006	In this study, we examined the effects of FN on D-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant liver failure in mice.	Galactosamine	65-69	fibronectin 1	Mus musculus	42-44
16369191-5	2006	GalN/LPS induced a marked decrease in plasma FN, which was reversed by FN pretreatment.	Galactosamine	0-4	fibronectin 1	Mus musculus	45-47
16369191-5	2006	GalN/LPS induced a marked decrease in plasma FN, which was reversed by FN pretreatment.	Galactosamine	0-4	fibronectin 1	Mus musculus	71-73
16369191-7	2006	FN prevented increases in the concentrations of serum enzymes and total bilirubin related to liver injury.	Bilirubin	72-81	fibronectin 1	Mus musculus	0-2
16369191-11	2006	These results suggest that FN protected against GalN/LPS-induced liver failure by a mechanism involving inhibition of NF-kappaB activation, which caused down-regulation of TNF-alpha and involved up-regulation of IL-10, and elevation of Bcl-xL induced a blockage of apoptotic signals, by which apoptosis of hepatocytes caused by GalN/LPS was suppressed.	Galactosamine	48-52	fibronectin 1	Mus musculus	27-29
16369191-11	2006	These results suggest that FN protected against GalN/LPS-induced liver failure by a mechanism involving inhibition of NF-kappaB activation, which caused down-regulation of TNF-alpha and involved up-regulation of IL-10, and elevation of Bcl-xL induced a blockage of apoptotic signals, by which apoptosis of hepatocytes caused by GalN/LPS was suppressed.	Galactosamine	328-332	fibronectin 1	Mus musculus	27-29
16359123-5	2005	When B16LuF10 cell gangliosides were used in combination with fibronectin, gangliosides removed the migration inhibitory effect of fibronectin resulting in net enhancing effect.	Gangliosides	19-31	fibronectin 1	Mus musculus	131-142
16359123-0	2005	Gangliosides enhance migration of mouse B16-melanoma cells through artificial basement membrane alone or in presence of laminin or fibronectin.	Gangliosides	0-12	fibronectin 1	Mus musculus	131-142
16359123-3	2005	Moreover, B16LuF10 cell gangliosides modified the migratory effect of laminin and fibronectin on B16LuF1 cells.	Gangliosides	24-36	fibronectin 1	Mus musculus	82-93
15792542-0	2005	The effect of the surface modification of titanium using a recombinant fragment of fibronectin and vitronectin on cell behavior.	Titanium	42-50	fibronectin 1	Mus musculus	83-94
15792542-5	2005	In addition, we confirmed that the surface properties of titanium prefer for FN(8-10) over VN(NTD) (p&lt;0.05) in protein adhesion.	Titanium	57-65	fibronectin 1	Mus musculus	77-79
16299147-5	2005	RESULTS: High glucose stimulated a striking increase in BRPC gremlin mRNA levels in parallel with increases in mRNA for the growth factors vascular endothelial growth factor (VEGF), transforming growth factor beta (TGFbeta), and connective tissue growth factor (CTGF) and changes in other genes including fibronectin and plasminogen activator inhibitor-1 (PAI-1).	Glucose	14-21	fibronectin 1	Mus musculus	305-316
16359123-5	2005	When B16LuF10 cell gangliosides were used in combination with fibronectin, gangliosides removed the migration inhibitory effect of fibronectin resulting in net enhancing effect.	Gangliosides	75-87	fibronectin 1	Mus musculus	62-73
16359123-5	2005	When B16LuF10 cell gangliosides were used in combination with fibronectin, gangliosides removed the migration inhibitory effect of fibronectin resulting in net enhancing effect.	Gangliosides	75-87	fibronectin 1	Mus musculus	131-142
16321227-9	2005	Over-expressed PPARgamma1 significantly inhibited the high glucose-induced increases in TGF-beta1, PAI-1 and fibronectin syntheses (all P &lt; 0.05).	Glucose	59-66	fibronectin 1	Mus musculus	109-120
15861408-7	2005	Additionally, among the extracellular matrix proteins analyzed, expression of fibronectin was elevated in the RXRalpha-/- as assessed by immunostaining in paraffin-embedded sections and proepicardial explants.	Paraffin	155-163	fibronectin 1	Mus musculus	78-89
15939815-5	2005	Overexpression of atrial and brain natriuretic peptides, collagen, and fibronectin mRNAs in GCA-KO mice was also attenuated by FK506.	Tacrolimus	127-132	fibronectin 1	Mus musculus	71-82
15653713-0	2005	Ethanol stimulates the expression of fibronectin in lung fibroblasts via kinase-dependent signals that activate CREB.	Ethanol	0-7	fibronectin 1	Mus musculus	37-48
15920148-5	2005	Histologically, the increases in mesangial area and the accumulation of fibronectin were significantly inhibited by 17beta-estradiol.	Estradiol	116-132	fibronectin 1	Mus musculus	72-83
15920148-7	2005	Raloxifene significantly reduced mesangial expansion and fibronectin accumulation in db/db mice, but in contrast to 17beta-estradiol, it failed to affect body weight or hyperglycemia.	Raloxifene Hydrochloride	0-10	fibronectin 1	Mus musculus	57-68
15920148-8	2005	An in vitro experiment further demonstrated that raloxifene inhibited transforming growth factor beta-1-induced fibronectin transcription and AP-1 activity.	Raloxifene Hydrochloride	49-59	fibronectin 1	Mus musculus	112-123
15980944-5	2005	We also found that high glucose significantly stimulated TFB cells to produce profibrotic molecules, such as type I collagen, the EIIIA isoform of fibronectin, and plasminogen activator inhibitor-1.	Glucose	24-31	fibronectin 1	Mus musculus	147-158
15980944-5	2005	We also found that high glucose significantly stimulated TFB cells to produce profibrotic molecules, such as type I collagen, the EIIIA isoform of fibronectin, and plasminogen activator inhibitor-1.	tfb	57-60	fibronectin 1	Mus musculus	147-158
15653713-4	2005	In cultured NIH/3T3 cells and in primary rat and mouse lung fibroblasts, ethanol induced fibronectin mRNA and protein expression in a dose- and time-dependent fashion.	Ethanol	73-80	fibronectin 1	Mus musculus	89-100
15653713-5	2005	The effect of ethanol was prevented by inhibitors of protein kinase C and mitogen-activated protein kinases and was associated with the phosphorylation and increased DNA binding of the transcription factor cAMP response element binding protein, followed by increased transcription of the fibronectin gene.	Ethanol	14-21	fibronectin 1	Mus musculus	288-299
15653713-5	2005	The effect of ethanol was prevented by inhibitors of protein kinase C and mitogen-activated protein kinases and was associated with the phosphorylation and increased DNA binding of the transcription factor cAMP response element binding protein, followed by increased transcription of the fibronectin gene.	Cyclic AMP	206-210	fibronectin 1	Mus musculus	288-299
15653713-6	2005	Fibroblasts were found to express alpha(7) nicotinic acetylcholine receptor (nAChR), and ethanol induction of fibronectin was abolished by alpha-bungarotoxin and methyllcaconitine, inhibitors of alpha(7) nAChRs.	Ethanol	89-96	fibronectin 1	Mus musculus	110-121
15653713-6	2005	Fibroblasts were found to express alpha(7) nicotinic acetylcholine receptor (nAChR), and ethanol induction of fibronectin was abolished by alpha-bungarotoxin and methyllcaconitine, inhibitors of alpha(7) nAChRs.	methyllcaconitine	162-179	fibronectin 1	Mus musculus	110-121
15653713-6	2005	Fibroblasts were found to express alpha(7) nicotinic acetylcholine receptor (nAChR), and ethanol induction of fibronectin was abolished by alpha-bungarotoxin and methyllcaconitine, inhibitors of alpha(7) nAChRs.	nachrs	204-210	fibronectin 1	Mus musculus	110-121
15653713-7	2005	However, ethanol was able to induce fibronectin mRNA and protein in primary lung fibroblasts isolated from alpha(7) nAChR knockout mice.	Ethanol	9-16	fibronectin 1	Mus musculus	36-47
15653713-8	2005	The ethanol-induced fibronectin response was dependent on ethanol metabolism since 4-methylpyrazole, an inhibitor of alcohol dehydrogenase, abolished the effect and acetaldehyde induced it.	Ethanol	4-11	fibronectin 1	Mus musculus	20-31
15653713-8	2005	The ethanol-induced fibronectin response was dependent on ethanol metabolism since 4-methylpyrazole, an inhibitor of alcohol dehydrogenase, abolished the effect and acetaldehyde induced it.	Ethanol	58-65	fibronectin 1	Mus musculus	20-31
15653713-8	2005	The ethanol-induced fibronectin response was dependent on ethanol metabolism since 4-methylpyrazole, an inhibitor of alcohol dehydrogenase, abolished the effect and acetaldehyde induced it.	Fomepizole	83-99	fibronectin 1	Mus musculus	20-31
15653713-8	2005	The ethanol-induced fibronectin response was dependent on ethanol metabolism since 4-methylpyrazole, an inhibitor of alcohol dehydrogenase, abolished the effect and acetaldehyde induced it.	Acetaldehyde	165-177	fibronectin 1	Mus musculus	20-31
15653713-9	2005	These observations suggest that ethanol or ethanol metabolites stimulate lung fibroblasts to produce fibronectin by inducing specific signals transmitted via nAChRs independent of the alpha(7-)subunit, and this might represent a mechanism by which ethanol renders the lung susceptible to acute lung injury.	Ethanol	32-39	fibronectin 1	Mus musculus	101-112
15653713-9	2005	These observations suggest that ethanol or ethanol metabolites stimulate lung fibroblasts to produce fibronectin by inducing specific signals transmitted via nAChRs independent of the alpha(7-)subunit, and this might represent a mechanism by which ethanol renders the lung susceptible to acute lung injury.	Ethanol	43-50	fibronectin 1	Mus musculus	101-112
15653713-9	2005	These observations suggest that ethanol or ethanol metabolites stimulate lung fibroblasts to produce fibronectin by inducing specific signals transmitted via nAChRs independent of the alpha(7-)subunit, and this might represent a mechanism by which ethanol renders the lung susceptible to acute lung injury.	Ethanol	43-50	fibronectin 1	Mus musculus	101-112
15691824-9	2005	In conclusion, externalized GTP-bound TG2 serves as a molecular switch for differentiation of chondrocytes to a hypertrophic, calcifying phenotype in a manner that does not require either TG2 transamidation activity or fibronectin binding.	Guanosine Triphosphate	28-31	fibronectin 1	Mus musculus	219-230
15814670-4	2005	The present study demonstrates that HC, but not PC, IgEs can efficiently induce adhesion and spreading of mouse mast cells on fibronectin-coated plates in slow and sustained kinetics.	Hydrocortisone	36-38	fibronectin 1	Mus musculus	126-137
15496516-5	2005	Aberrant activation of beta-catenin by LiCl, a well-known glycogen synthase kinase-3 inhibitor, significantly inhibited blastocyst hatching and subsequent adhesion and outgrowth on fibronectin.	Lithium Chloride	39-43	fibronectin 1	Mus musculus	181-192
16301823-8	2005	Exposure to high extracellular glucose concentration stimulated fibronectin formation (by 2.2 fold), an effect abrogated by transfection with inactive (K127N)SGK1 (1.2 fold) and markedly enhanced by transfection with (S422D)SGK1 (4.7 fold).	Glucose	31-38	fibronectin 1	Mus musculus	64-75
15651048-0	2005	Oligosaccharide mimics containing galactose and fucose specifically label tumour cell surfaces and inhibit cell adhesion to fibronectin.	Oligosaccharides	0-15	fibronectin 1	Mus musculus	124-135
15625681-0	2005	Fibronectin adsorption and arrangement on copolymer surfaces and their significance in cell adhesion.	copolymer	42-51	fibronectin 1	Mus musculus	0-11
15625681-1	2005	The adsorption of fibronectin (FN) to (styrene/methyl methacrylate) copolymer surfaces, both sulfonated (hydrophilic) and nonsulfonated (hydrophobic), was studied by means of the radioisotope (125I-FN) and ELISA assays; the latter employed monoclonal antibodies.	styrene/methyl methacrylate	39-66	fibronectin 1	Mus musculus	18-29
15625681-1	2005	The adsorption of fibronectin (FN) to (styrene/methyl methacrylate) copolymer surfaces, both sulfonated (hydrophilic) and nonsulfonated (hydrophobic), was studied by means of the radioisotope (125I-FN) and ELISA assays; the latter employed monoclonal antibodies.	styrene/methyl methacrylate	39-66	fibronectin 1	Mus musculus	31-33
15625681-1	2005	The adsorption of fibronectin (FN) to (styrene/methyl methacrylate) copolymer surfaces, both sulfonated (hydrophilic) and nonsulfonated (hydrophobic), was studied by means of the radioisotope (125I-FN) and ELISA assays; the latter employed monoclonal antibodies.	copolymer	68-77	fibronectin 1	Mus musculus	18-29
15625681-1	2005	The adsorption of fibronectin (FN) to (styrene/methyl methacrylate) copolymer surfaces, both sulfonated (hydrophilic) and nonsulfonated (hydrophobic), was studied by means of the radioisotope (125I-FN) and ELISA assays; the latter employed monoclonal antibodies.	copolymer	68-77	fibronectin 1	Mus musculus	31-33
15653993-7	2005	RESULTS: FP, 1 micromol/L, inhibited the expression of fibronectin messenger RNA and protein in unstimulated NIH-3T3 cells and primary lung fibroblasts, as well as in fibroblasts stimulated with nicotine.	Nicotine	195-203	fibronectin 1	Mus musculus	55-66
15651048-0	2005	Oligosaccharide mimics containing galactose and fucose specifically label tumour cell surfaces and inhibit cell adhesion to fibronectin.	Galactose	34-43	fibronectin 1	Mus musculus	124-135
15651048-0	2005	Oligosaccharide mimics containing galactose and fucose specifically label tumour cell surfaces and inhibit cell adhesion to fibronectin.	Fucose	48-54	fibronectin 1	Mus musculus	124-135
15651048-7	2005	Adhesion of the highly metastatic mouse melanoma line B16 F10 to fibronectin was inhibited by 80 % by the TMC-digalactoside and by 30 % by 3,4-bis-(beta-D-galactopyranosyloxymethyl)furan.	tmc-digalactoside	106-123	fibronectin 1	Mus musculus	65-76
15651048-7	2005	Adhesion of the highly metastatic mouse melanoma line B16 F10 to fibronectin was inhibited by 80 % by the TMC-digalactoside and by 30 % by 3,4-bis-(beta-D-galactopyranosyloxymethyl)furan.	3,4-bis-(beta-d-galactopyranosyloxymethyl)furan	139-186	fibronectin 1	Mus musculus	65-76
15570020-6	2004	After intake of the 5 cysteine-containing agents for 4 wk, body weight loss, plasma concentrations of glucose and insulin, and fibronectin levels were improved (P &lt; 0.05) in diabetic mice.	Cysteine	22-30	fibronectin 1	Mus musculus	127-138
16178272-9	2005	The increase in cell adhesion was observed on plastic dishes, albumin, as well as on fibronectin pre-coated ones suggesting that heparin effect is substratum independent.	Heparin	129-136	fibronectin 1	Mus musculus	85-96
15481053-0	2004	Fibronectin adsorption on surface-activated poly(dimethylsiloxane) and its effect on cellular function.	baysilon	44-65	fibronectin 1	Mus musculus	0-11
15481053-1	2004	This article reports that surface modification of poly(dimethylsiloxane) (PDMS) influences fibronectin (Fn) adsorption and enhances cell attachment.	baysilon	50-72	fibronectin 1	Mus musculus	91-102
15481053-1	2004	This article reports that surface modification of poly(dimethylsiloxane) (PDMS) influences fibronectin (Fn) adsorption and enhances cell attachment.	baysilon	50-72	fibronectin 1	Mus musculus	104-106
15481053-2	2004	Controlled adsorption of Fn on chemically activated polymer substrates is known to influence cellular function.	Polymers	52-59	fibronectin 1	Mus musculus	25-27
15383613-10	2004	A constitutively active permeant form of RhoA (TAT-RhoA(Val-14)) also restored motility on fibronectin of STn+ cells as well as a parental STn-cellular phenotype.	Valine	56-59	fibronectin 1	Mus musculus	91-102
15456495-6	2004	Spreading on fibronectin promotes alpha(IIb)beta(3)-mediated Ca(2+) mobilization and tyrosine phosphorylation of focal adhesion kinase and phospholipase C gamma2.	Tyrosine	85-93	fibronectin 1	Mus musculus	13-24
15561270-4	2004	We studied the therapeutic effect of plasma Fn in mice after an intraperitoneal injection of lipopolysaccharide (LPS) and d-galactosamine (GalN).	Galactosamine	122-137	fibronectin 1	Mus musculus	44-46
15561270-7	2004	A single administration of plasma Fn (500 mg/kg) protected in dose-dependent fashion against lethal shock after GalN/LPS challenge.	Galactosamine	112-116	fibronectin 1	Mus musculus	34-36
15561270-8	2004	Plasma Fn significantly reduced the serum tumor necrosis factor-alpha, interferon-gamma, and interleukin-6 levels and significantly increased the serum interleukin-10 levels after GalN/LPS administration.	Galactosamine	180-184	fibronectin 1	Mus musculus	7-9
15225627-3	2004	Here, we show that combination of fibronectin coating with 17beta-estradiol increased number of generated neurons over 50%.	Estradiol	59-75	fibronectin 1	Mus musculus	34-45
15197007-2	2004	Previous work demonstrated that arachidonate oxidation to leukotriene B(4) (LTB(4)) by 5-lipoxygenase (5-LOX) signals fibroblast spreading on fibronectin, whereas cyclooxygenase-2 (COX-2)-catalyzed prostaglandin E(2) (PGE(2)) formation facilitates subsequent cell migration.	Arachidonic Acid	32-44	fibronectin 1	Mus musculus	142-153
15197007-2	2004	Previous work demonstrated that arachidonate oxidation to leukotriene B(4) (LTB(4)) by 5-lipoxygenase (5-LOX) signals fibroblast spreading on fibronectin, whereas cyclooxygenase-2 (COX-2)-catalyzed prostaglandin E(2) (PGE(2)) formation facilitates subsequent cell migration.	Leukotriene B4	58-71	fibronectin 1	Mus musculus	142-153
14998999-7	2004	In addition, the affinity of the binding of integrin alpha(5)beta(1) to fibronectin was significantly reduced by the introduction of the bisecting GlcNAc, to the alpha(5) subunit.	2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose	147-153	fibronectin 1	Mus musculus	72-83
15330857-5	2004	Methyl-beta-cyclodextrin (MBCD), an inhibitor of lipid raft formation, inhibited the integrin-fibronectin interaction-dependent adhesion of NECs.	methyl-beta-cyclodextrin	0-24	fibronectin 1	Mus musculus	94-105
15231043-7	2004	Moreover, the intraperitoneal administration of fumigaclavine C inhibited the potential of spleen cells isolated from the liver-injured mice to adhere to fibronectin, laminin and type IV collagen.	fumigaclavine C	48-63	fibronectin 1	Mus musculus	154-165
15086458-0	2004	Cultured tubule cells from TGF-beta1 null mice exhibit impaired hypertrophy and fibronectin expression in high glucose.	Glucose	111-118	fibronectin 1	Mus musculus	80-91
14761956-3	2004	Here we describe that ADAM8, a member of the family of metalloprotease disintegrins cleaves a CHL1-Fc fusion protein in vitro at two sites corresponding to release of the extracellular domain of CHL1 in fibronectin (FN) domains II (125 kDa) and V (165 kDa), inhibited by batimastat (BB-94).	batimastat	271-281	fibronectin 1	Mus musculus	203-214
15056871-7	2004	When tumor cells were seeded on fibronectin-coated plates with evodiamine, their spreading on the plate was obviously inhibited, while their adhesiveness to fibronectin was unaffected.	evodiamine	63-73	fibronectin 1	Mus musculus	32-43
15276326-6	2004	Either cell detachment or apoptotic response induced by echistatin were more pronounced on fibronectin-adherent GD25 cells than on vitronectin-adherent ones.	echistatin	56-66	fibronectin 1	Mus musculus	91-102
15086458-10	2004	High glucose also increased fibronectin message and protein.	Glucose	5-12	fibronectin 1	Mus musculus	28-39
15086458-11	2004	However, in knockout cells, high glucose failed to induce hypertrophy and was severely limited in its capacity to stimulate fibronectin.	Glucose	33-40	fibronectin 1	Mus musculus	124-135
15086458-12	2004	CONCLUSION: In tubular epithelial cells, TGF-beta1 mediates the hypertrophic and fibronectin-stimulatory effects of high glucose, confirming the role of the TGF-beta1 isoform in the pathogenesis of diabetic tubular hypertrophy and fibronectin overexpression.	Glucose	121-128	fibronectin 1	Mus musculus	81-92
14704308-8	2004	Intake of the five cysteine-containing compounds reduced fibronectin, TG and cholesterol concentrations in plasma and liver, and increased the alpha-tocopherol concentration in plasma, kidney and liver compared with the control and cysteine-treated groups (P&lt;0.05).	Cysteine	19-27	fibronectin 1	Mus musculus	57-68
15104095-4	2004	In addition, astilbin inhibited the adhesion of spleen cells and purified T lymphocytes isolated from the liver-injured mice to fibronectin, laminin and type IV collagen.Moreover, the adhesion of human Jurkat T cells to endothelial cell line ECV-304 was also inhibited by astilbin.	astilbin	13-21	fibronectin 1	Mus musculus	128-139
14997472-3	2004	In the present study, we designed multifunctional peptide fibrils using the A208 peptide and an Arg-Gly-Asp (RGD)-containing fibronectin active sequence for biomedical applications.	arginyl-glycyl-aspartic acid	96-107	fibronectin 1	Mus musculus	125-136
14997472-4	2004	The fibronectin active sequence GRGDS (FN) or a scrambled sequence RSGGD (SC) were conjugated to either A208 or to A208S (AASVVIAKSADR), a scrambled peptide of A208, with a glycine as a spacer.	Glycine	173-180	fibronectin 1	Mus musculus	4-15
14693716-3	2004	TGF-beta 1 enhanced fibronectin mRNA expression, and this enhancement was abrogated by pretreatment with pioglitazone.	Pioglitazone	105-117	fibronectin 1	Mus musculus	20-31
14693716-7	2004	15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), a natural PPAR-gamma ligand, also inhibited TGF-beta1-induced fibronectin expression by suppressing AP-1 activation by TGF-beta 1.	15-deoxy-delta	0-14	fibronectin 1	Mus musculus	117-128
14693716-7	2004	15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), a natural PPAR-gamma ligand, also inhibited TGF-beta1-induced fibronectin expression by suppressing AP-1 activation by TGF-beta 1.	-prostaglandin j	21-37	fibronectin 1	Mus musculus	117-128
14693716-11	2004	In conclusion, pioglitazone inhibits TGF-beta 1-induced fibronectin expression by inhibiting AP-1 activation dependent on PPAR-gamma, while 15d-PGJ(2) acts through a dual mechanism independent of and dependent on PPAR-gamma activation in mouse mesangial cells.	Pioglitazone	15-27	fibronectin 1	Mus musculus	56-67
14742647-6	2004	On the other hand, TiO formed on the Ti-Cl surface enhanced cell extension and cell growth through a larger adsorption of fibronectin compared with the pure titanium control.	tio	19-22	fibronectin 1	Mus musculus	122-133
14742647-6	2004	On the other hand, TiO formed on the Ti-Cl surface enhanced cell extension and cell growth through a larger adsorption of fibronectin compared with the pure titanium control.	ti-cl	37-42	fibronectin 1	Mus musculus	122-133
14585852-14	2003	MRSA infection significantly increased fibronectin and interleukin-6 levels in plasma of MRSA-infected mice (P&lt;0.05); however, the oral administration of garlic extract and two diallyl sulphides significantly reduced both fibronectin and interleukin-6 levels (P&lt;0.05).	allyl sulfide	180-197	fibronectin 1	Mus musculus	39-50
14585852-14	2003	MRSA infection significantly increased fibronectin and interleukin-6 levels in plasma of MRSA-infected mice (P&lt;0.05); however, the oral administration of garlic extract and two diallyl sulphides significantly reduced both fibronectin and interleukin-6 levels (P&lt;0.05).	allyl sulfide	180-197	fibronectin 1	Mus musculus	225-236
12124321-5	2002	Because the EC domain interacts with fibronectin and DTT abrogates the inhibitory effects of the EC, we speculate that super-fibronectin may function with the EC as a suppressor of cancer cells.	Dithiothreitol	53-56	fibronectin 1	Mus musculus	125-136
15344420-3	2004	The plant extract, 27 microl/ml (equivalent to 0.54 mg/of plant leaves powder per ml of culture medium), as well as gnidilatimonoein (0.94 microM), were capable of quenching by 58% and 64%, respectively, the attachment of wehi-164 cells to fibronectin-coated wells (4 microg/ml).	gnidilatimonoein	116-132	fibronectin 1	Mus musculus	240-251
12702510-5	2003	Interestingly, we found, using the calcium channel blocker, 2-APB (2-aminoethoxydiphenyl borate) and Lyn-/- BMMCs that both IgE- and IgE + Ag-induced adhesion to FN require extracellular calcium entry, whereas SF does not.	2-aminoethoxydiphenyl borate	60-65	fibronectin 1	Mus musculus	162-164
12702510-5	2003	Interestingly, we found, using the calcium channel blocker, 2-APB (2-aminoethoxydiphenyl borate) and Lyn-/- BMMCs that both IgE- and IgE + Ag-induced adhesion to FN require extracellular calcium entry, whereas SF does not.	2-aminoethoxydiphenyl borate	67-95	fibronectin 1	Mus musculus	162-164
12466149-5	2003	Fibronectin and bFGF also significantly augmented invasion of myoblasts across a Matrigel barrier, and plasmin cotreatment potentiated whereas N-acetyl cysteine suppressed the effects of bFGF and fibronectin on myoblast migration and invasion.	Acetylcysteine	143-160	fibronectin 1	Mus musculus	0-11
12466149-5	2003	Fibronectin and bFGF also significantly augmented invasion of myoblasts across a Matrigel barrier, and plasmin cotreatment potentiated whereas N-acetyl cysteine suppressed the effects of bFGF and fibronectin on myoblast migration and invasion.	Acetylcysteine	143-160	fibronectin 1	Mus musculus	196-207
12678405-5	2003	The binding to fibronectin, vitronectin, and collagen IV decreased by over 50% in 24 hours, and by 100% after 48 hours of curcumin treatment, it persisted at this level even after 15 days of cultivating cells in curcumin-free medium.	Curcumin	122-130	fibronectin 1	Mus musculus	15-26
12678405-5	2003	The binding to fibronectin, vitronectin, and collagen IV decreased by over 50% in 24 hours, and by 100% after 48 hours of curcumin treatment, it persisted at this level even after 15 days of cultivating cells in curcumin-free medium.	Curcumin	212-220	fibronectin 1	Mus musculus	15-26
14520012-8	2003	The mRNA expression of laminin and fibronectin under high-glucose conditions only slightly increased.	Glucose	58-65	fibronectin 1	Mus musculus	35-46
14520012-9	2003	Enalaprilat decreased the fibronectin mRNA synthesis dramatically (&gt;50%, p &lt; 0.0001) under high-glucose conditions.	Enalaprilat	0-11	fibronectin 1	Mus musculus	26-37
14520012-9	2003	Enalaprilat decreased the fibronectin mRNA synthesis dramatically (&gt;50%, p &lt; 0.0001) under high-glucose conditions.	Glucose	102-109	fibronectin 1	Mus musculus	26-37
14520012-10	2003	CONCLUSIONS: Enalaprilat normalizes the abnormal, high-glucose-induced concentration of laminin, while it decreases the fibronectin synthesis.	Enalaprilat	13-24	fibronectin 1	Mus musculus	120-131
14577329-8	2003	P-815 cells are demonstrated to bind to Pronectin-F, a proteolytic fragment of fibronectin, in adhesion protein of the extracellular matrix, by addition of PGE2, which is mediated by PKA.	Dinoprostone	156-160	fibronectin 1	Mus musculus	79-90
14577329-10	2003	These findings indicate that two subtypes of PGE2 receptors, EP3 and EP4, cooperatively activate the cAMP-mediated adhesion event through induction of fibronectin ligand elicited by PGE2 in P-815 cells.	Cyclic AMP	101-105	fibronectin 1	Mus musculus	151-162
14577329-10	2003	These findings indicate that two subtypes of PGE2 receptors, EP3 and EP4, cooperatively activate the cAMP-mediated adhesion event through induction of fibronectin ligand elicited by PGE2 in P-815 cells.	Dinoprostone	45-49	fibronectin 1	Mus musculus	151-162
14504666-7	2003	N-desulfated heparin significantly inhibited the adhesion of spleen cells and purified T lymphocytes isolated from the liver injured mice to either type I collagen or fibronectin but not to laminin.	Nitrogen	0-1	fibronectin 1	Mus musculus	167-178
14504666-7	2003	N-desulfated heparin significantly inhibited the adhesion of spleen cells and purified T lymphocytes isolated from the liver injured mice to either type I collagen or fibronectin but not to laminin.	desulfated heparin	2-20	fibronectin 1	Mus musculus	167-178
12970880-1	2003	AIM: To investigate the inhibitory effect of in vivo expression of expressing plasmid pCH510 of recombinant fibronectin polypeptide (CH50) on hepatocellular carcinoma and the improved therapeutic effect of pCH510 in combination with chemotherapeutic agents and Hsp70-H22 hepatocarcinoma antigen peptide on tumor.	pch510	86-92	fibronectin 1	Mus musculus	108-119
12970880-1	2003	AIM: To investigate the inhibitory effect of in vivo expression of expressing plasmid pCH510 of recombinant fibronectin polypeptide (CH50) on hepatocellular carcinoma and the improved therapeutic effect of pCH510 in combination with chemotherapeutic agents and Hsp70-H22 hepatocarcinoma antigen peptide on tumor.	pch510	206-212	fibronectin 1	Mus musculus	108-119
12818160-6	2003	These results point to an essential role for galactolipids in the formation of fibronectin-enriched lymphoid-specific stromal niches in the BM.	Galactolipids	45-58	fibronectin 1	Mus musculus	79-90
12765196-7	2003	The results demonstrated that both taxol and CPT could inhibit the migration of B16F10 cells, and inhibit the adhesion of B16F10 to fibronectin and laminin.	Paclitaxel	35-40	fibronectin 1	Mus musculus	132-143
12765196-7	2003	The results demonstrated that both taxol and CPT could inhibit the migration of B16F10 cells, and inhibit the adhesion of B16F10 to fibronectin and laminin.	Camptothecin	45-48	fibronectin 1	Mus musculus	132-143
12637575-2	2003	We report that PGE(2) accelerated ProNectin F(TM) (a proteolytic fragment of fibronectin)-mediated adhesion, which was abolished by addition of the GRGDS peptide, an inhibitor of the RDG binding site of ProNectin F(TM).	Prostaglandins E	15-18	fibronectin 1	Mus musculus	77-88
12631354-8	2003	L-Arginine administration increased albuminuria, renal matrix accumulation, TGF-beta 1, fibronectin, PAI-1, blood L-arginine, L-citrulline, BUN and blood and urine NOx levels, while protein restriction reduced these parameters.	Arginine	0-10	fibronectin 1	Mus musculus	88-99
12455030-5	2003	Then, cell adhesion to fibronectin-coated dishes was examined, showing that GM(2) (+) transfectants attached to the plates much more slowly than controls, suggesting functional modulation of integrins with newly expressed GM(2).	gm(2) (+)	76-85	fibronectin 1	Mus musculus	23-34
12455030-5	2003	Then, cell adhesion to fibronectin-coated dishes was examined, showing that GM(2) (+) transfectants attached to the plates much more slowly than controls, suggesting functional modulation of integrins with newly expressed GM(2).	gm(2)	76-81	fibronectin 1	Mus musculus	23-34
12455030-6	2003	Phosphorylation of the FAK located at downstream of integrin molecules was markedly reduced in GM(2)(+) transfectants, suggesting that GM(2) suppressed cell adhesion signals via fibronectin-integrin interaction.	gm(2)(+)	95-103	fibronectin 1	Mus musculus	178-189
12455030-6	2003	Phosphorylation of the FAK located at downstream of integrin molecules was markedly reduced in GM(2)(+) transfectants, suggesting that GM(2) suppressed cell adhesion signals via fibronectin-integrin interaction.	gm(2)	95-100	fibronectin 1	Mus musculus	178-189
12507235-6	2002	In addition, the amount of fibronectin adsorption on each Ti plate was investigated by enzyme-linked immunosorbent assay and fluorescein isothiocyanate labeling.	Fluorescein-5-isothiocyanate	125-151	fibronectin 1	Mus musculus	27-38
12507235-9	2002	Fibronectin adsorption on titanium plates was increased by GDP.	Guanosine Diphosphate	59-62	fibronectin 1	Mus musculus	0-11
12385003-6	2002	AS-ODN and LT also inhibited the tyrosine phosphorylation of FAK when cells were plated on vitronectin, fibronectin, or type-1 collagen.	Tyrosine	33-41	fibronectin 1	Mus musculus	104-115
12370392-6	2002	Thrombin and the PAR-1-activating peptide AparafluoroFRCyclohexylACitY-NH(2) (cit) induced BMCMC adhesion to FN in a dose-dependent fashion, while the PAR-1-inactive peptide FSLLRY-NH(2) had no effect.	bmcmc	91-96	fibronectin 1	Mus musculus	109-111
12207925-7	2002	In mesangial cells, high glucose potentiated the effect of low-dose TGF-beta1 (0.2ng/ml) on the following TGF-beta-responsive constructs: 3TP-Lux (containing AP-1 sites and PAI-1 promoter), SBE4-Luc (containing four tandem repeats of SBE sequence), and the fibronectin promoter.	Glucose	25-32	fibronectin 1	Mus musculus	257-268
12207925-8	2002	Additionally, Smad3 overexpression increased fibronectin promoter activity, an effect that was enhanced by high ambient glucose or treatment with TGF-beta1 (2ng/ml).	Glucose	120-127	fibronectin 1	Mus musculus	45-56
12237541-0	2002	Preparation and biological activities of a bivalent poly(ethylene glycol) hybrid containing an active site and its synergistic site of fibronectin.	Polyethylene Glycols	52-73	fibronectin 1	Mus musculus	135-146
12237541-1	2002	A bivalent poly(ethylene glycol) or PEG hybrid of fibronectin-related peptides was prepared.	Polyethylene Glycols	11-31	fibronectin 1	Mus musculus	50-61
12237541-1	2002	A bivalent poly(ethylene glycol) or PEG hybrid of fibronectin-related peptides was prepared.	Polyethylene Glycols	36-39	fibronectin 1	Mus musculus	50-61
12237541-2	2002	An active site peptide (RGD) and its synergistic site peptide (PHSRN) of fibronectin were conjugated with an amino acid-type PEG (aaPEG) to form PHSRN-aaPEG-RGD.	Polyethylene Glycols	125-128	fibronectin 1	Mus musculus	73-84
12021063-10	2002	Based on our data, we propose here, to our knowledge for the first time, that alpha4beta1 integrin, which is responsible for binding to fibronectin and vascular cell adhesion molecule-1, is induced by estradiol and is down-regulated by progesterone in mice during implantation.	Progesterone	236-248	fibronectin 1	Mus musculus	136-147
11916349-10	2001	PS supplementation reduced the binding of PC-3 cells to laminin by 15-38% and fibronectin by 23% while cholesterol increased binding to type IV collagen by 36%.	Phytosterols	0-2	fibronectin 1	Mus musculus	78-89
12400610-2	2002	Stimulation through beta1 integrins by fibronectin reversed apoptosis induced by adriamycin.	Doxorubicin	81-91	fibronectin 1	Mus musculus	39-50
11977980-0	2002	Integrin signaling regulates blastocyst adhesion to fibronectin at implantation: intracellular calcium transients and vesicle trafficking in primary trophoblast cells.	Calcium	95-102	fibronectin 1	Mus musculus	52-63
11977980-5	2002	Chelation of intracellular Ca(2+) using BAPTA-AM, or inhibition of the Ca(2+)-dependent proteins, protein kinase C or calmodulin, significantly attenuated the effect of FN on binding activity.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	40-48	fibronectin 1	Mus musculus	169-171
11977980-6	2002	Furthermore, direct elevation of cytoplasmic Ca(2+) levels with ionomycin upregulated FN-binding activity, demonstrating that Ca(2+) signaling is required and sufficient for strong adhesion to FN.	Ionomycin	64-73	fibronectin 1	Mus musculus	86-88
11977980-6	2002	Furthermore, direct elevation of cytoplasmic Ca(2+) levels with ionomycin upregulated FN-binding activity, demonstrating that Ca(2+) signaling is required and sufficient for strong adhesion to FN.	Ionomycin	64-73	fibronectin 1	Mus musculus	193-195
11926992-2	2002	The treatment of fibronectin-unstimulated and stimulated mouse thioglycolate-induced macrophages with inhibitors of myosin light chain kinase, protein kinase C and protein tyrosine kinase resulted in decreased macrophage binding of oxLDL, macrophage foam cell formation, and whole intracellular protein phosphorylation.	Thioglycolates	63-76	fibronectin 1	Mus musculus	17-28
11926992-6	2002	Treatment of fibronectin-unstimulated and stimulated macrophages with thiophosphate, which forms thiophosphate esters of intracellular proteins that are not so susceptible to protein phosphatases, enhanced macrophage binding of oxLDL.	thiophosphoric acid	70-83	fibronectin 1	Mus musculus	13-24
11926992-6	2002	Treatment of fibronectin-unstimulated and stimulated macrophages with thiophosphate, which forms thiophosphate esters of intracellular proteins that are not so susceptible to protein phosphatases, enhanced macrophage binding of oxLDL.	thiophosphate esters	97-117	fibronectin 1	Mus musculus	13-24
11786549-0	2002	The oxidized lipid and lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response element-binding protein activation.	Hydroxyeicosatetraenoic Acids	46-78	fibronectin 1	Mus musculus	103-114
11786549-0	2002	The oxidized lipid and lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response element-binding protein activation.	Cyclic AMP	178-182	fibronectin 1	Mus musculus	103-114
11849388-9	2002	Both heparin and non-anti-coagulant heparin blocked the accumulation of pFN-FITC, indicating that the protective effect of heparin in the trapping of FN is independent of its anticoagulant properties, and probably results from preventing direct binding of FN in the sclerotic lesions.	Heparin	5-12	fibronectin 1	Mus musculus	73-75
11849388-9	2002	Both heparin and non-anti-coagulant heparin blocked the accumulation of pFN-FITC, indicating that the protective effect of heparin in the trapping of FN is independent of its anticoagulant properties, and probably results from preventing direct binding of FN in the sclerotic lesions.	Heparin	36-43	fibronectin 1	Mus musculus	73-75
11849388-9	2002	Both heparin and non-anti-coagulant heparin blocked the accumulation of pFN-FITC, indicating that the protective effect of heparin in the trapping of FN is independent of its anticoagulant properties, and probably results from preventing direct binding of FN in the sclerotic lesions.	Heparin	36-43	fibronectin 1	Mus musculus	73-75
12028583-6	2002	A statistically significant increase in DOPA-positive cells was evident in FN and CLI wells.	Levodopa	40-44	fibronectin 1	Mus musculus	75-77
12133425-4	2002	RESULTS: (1) Tripterine suppressed the development of proteinuria, decreased the level of serum anti-dsDNA antibodies, reduced the expressions of collagen type IV, fibronectin, TIMP-1, TIMP-2, TGF-beta(1) and improved the expressions of MMP-1, -2 in the murine kidney.	celastrol	13-23	fibronectin 1	Mus musculus	164-175
11697891-3	2001	Tetracycline-regulated ADAM15 overexpression in NIH3T3 cells leads to an inhibition of migration on a fibronectin-coated filter in a Boyden chamber assay and in a scratch wound model.	Tetracycline	0-12	fibronectin 1	Mus musculus	102-113
11748259-5	2001	In the presence of the substrates hydrogen peroxide (H(2)O(2)) and NO(2)(-), cell and vessel wall-associated MPO catalyzed nitration of ECM protein tyrosine residues, with fibronectin identified as a major target protein.	Hydrogen Peroxide	34-51	fibronectin 1	Mus musculus	172-183
11748259-5	2001	In the presence of the substrates hydrogen peroxide (H(2)O(2)) and NO(2)(-), cell and vessel wall-associated MPO catalyzed nitration of ECM protein tyrosine residues, with fibronectin identified as a major target protein.	Water	53-58	fibronectin 1	Mus musculus	172-183
11748259-5	2001	In the presence of the substrates hydrogen peroxide (H(2)O(2)) and NO(2)(-), cell and vessel wall-associated MPO catalyzed nitration of ECM protein tyrosine residues, with fibronectin identified as a major target protein.	Tyrosine	148-156	fibronectin 1	Mus musculus	172-183
11737589-8	2001	Addition of neutralizing anti-HB-EGF antibody, as well as pretreatment with heparin or the metalloproteinase inhibitor batimastat abolished induction of FN expression by Ang II.	Heparin	76-83	fibronectin 1	Mus musculus	153-155
11737589-8	2001	Addition of neutralizing anti-HB-EGF antibody, as well as pretreatment with heparin or the metalloproteinase inhibitor batimastat abolished induction of FN expression by Ang II.	batimastat	119-129	fibronectin 1	Mus musculus	153-155
11484184-0	2001	Attachment of fibronectin to poly(vinyl alcohol) hydrogels promotes NIH3T3 cell adhesion, proliferation, and migration.	Polyvinyl Alcohol	29-48	fibronectin 1	Mus musculus	14-25
11723742-4	2001	The cell-binding domain obtained from fibronectin included the Arg-Gly-Asp (RGD) sequence.	Arginine	63-66	fibronectin 1	Mus musculus	38-49
11723742-4	2001	The cell-binding domain obtained from fibronectin included the Arg-Gly-Asp (RGD) sequence.	Glycine	67-70	fibronectin 1	Mus musculus	38-49
11723742-4	2001	The cell-binding domain obtained from fibronectin included the Arg-Gly-Asp (RGD) sequence.	Aspartic Acid	71-74	fibronectin 1	Mus musculus	38-49
11520804-6	2001	p185bcr-abl-transfected BaF3 cells preadhered to immobilized fibronectin had a significant survival advantage and reduced susceptibility to apoptosis following gamma-irradiation when compared with the same cells grown on laminin, on polylysin, or in suspension.	DL-Lysine	233-242	fibronectin 1	Mus musculus	61-72
11535514-7	2001	Immunohistochemical analysis showed differential up-regulation of the adhesion molecules ICAM-1, P-selectin, and fibronectin in liver and pancreas in heme-treated animals.	Heme	150-154	fibronectin 1	Mus musculus	113-124
11451994-3	2001	During the adhesion of NIH-3T3 cells to fibronectin, two functionally and kinetically distinct phases of arachidonic acid release take place.	Arachidonic Acid	105-121	fibronectin 1	Mus musculus	40-51
11737251-5	2001	Dexamethasone down-regulated fibronectin mRNA rapidly, within 2 h of treatment, in the stromal cells.	Dexamethasone	0-13	fibronectin 1	Mus musculus	29-40
11416044-0	2001	Fibronectin and the alpha(5)beta(1) integrin are under developmental and ovarian steroid regulation in the normal mouse mammary gland.	Steroids	81-88	fibronectin 1	Mus musculus	0-11
11416044-7	2001	Fibronectin was decreased 70% by ovariectomy and increased 1.5- and 2-fold by estrogen or estrogen plus progesterone treatment, respectively.	Progesterone	104-116	fibronectin 1	Mus musculus	0-11
11575473-4	2001	In contrast, on a polyacrylonitrile membrane (AN69) that favours the adsorption of vitronectin and fibronectin, cells spread out and contain low concentrations of cAM P.	polyacrylonitrile	18-35	fibronectin 1	Mus musculus	99-110
11451994-4	2001	An initial transient arachidonate release occurs during cell attachment to fibronectin, and is sufficient to signal the cell spreading stage after its oxidation by 5-lipoxygenase to leukotrienes.	Arachidonic Acid	21-33	fibronectin 1	Mus musculus	75-86
11451994-4	2001	An initial transient arachidonate release occurs during cell attachment to fibronectin, and is sufficient to signal the cell spreading stage after its oxidation by 5-lipoxygenase to leukotrienes.	Leukotrienes	182-194	fibronectin 1	Mus musculus	75-86
11396927-0	2001	Substrate-bound fibronectin enhances scavenger receptor activity of macrophages by calcium signaling.	Calcium	83-90	fibronectin 1	Mus musculus	16-27
11396927-2	2001	Here, the mechanisms of the enhancement of the scavenger receptor activity by the substrate-bound FN was investigated using thioglycollate-induced mouse peritoneal macrophages.	Thioglycolates	124-138	fibronectin 1	Mus musculus	98-100
11396927-3	2001	A Ca(2+) channel blocker diltiazem and a calmodulin inhibitor W-7 reduced the scavenger receptor activity of the macrophages plated on FN-coated substrate to the level of the cells plated on uncoated substrate, as assessed by oxLDL binding, while the scavenger receptor activity of the macrophages on uncoated substrate was little affected.	Diltiazem	25-34	fibronectin 1	Mus musculus	135-137
11396927-4	2001	Similarly, FN-induced enhancement of the scavenger receptor activity assessed by oxLDL uptake was selectively inhibited by Ca(2+) channel blockers (diltiazem, nifedipine, verapamil) and calmodulin inhibitors (W-7, trifluoperazine).	Diltiazem	148-157	fibronectin 1	Mus musculus	11-13
11396927-4	2001	Similarly, FN-induced enhancement of the scavenger receptor activity assessed by oxLDL uptake was selectively inhibited by Ca(2+) channel blockers (diltiazem, nifedipine, verapamil) and calmodulin inhibitors (W-7, trifluoperazine).	Nifedipine	159-169	fibronectin 1	Mus musculus	11-13
11396927-4	2001	Similarly, FN-induced enhancement of the scavenger receptor activity assessed by oxLDL uptake was selectively inhibited by Ca(2+) channel blockers (diltiazem, nifedipine, verapamil) and calmodulin inhibitors (W-7, trifluoperazine).	Verapamil	171-180	fibronectin 1	Mus musculus	11-13
11396927-4	2001	Similarly, FN-induced enhancement of the scavenger receptor activity assessed by oxLDL uptake was selectively inhibited by Ca(2+) channel blockers (diltiazem, nifedipine, verapamil) and calmodulin inhibitors (W-7, trifluoperazine).	W 7	209-212	fibronectin 1	Mus musculus	11-13
11396927-4	2001	Similarly, FN-induced enhancement of the scavenger receptor activity assessed by oxLDL uptake was selectively inhibited by Ca(2+) channel blockers (diltiazem, nifedipine, verapamil) and calmodulin inhibitors (W-7, trifluoperazine).	Trifluoperazine	214-229	fibronectin 1	Mus musculus	11-13
11396927-6	2001	This increase in the Ca(2+) level was inhibited by diltiazem and RGD-containing peptides present in cell adhesive region of FN.	Diltiazem	51-60	fibronectin 1	Mus musculus	124-126
11396927-7	2001	Like the substrate-bound FN, Ca(2+) ionophore A23187 enhanced the scavenger receptor activity of binding and taking up of oxLDL.	Calcimycin	46-52	fibronectin 1	Mus musculus	25-27
11396927-9	2001	A microtubule disruptor, colchicine, and an actin filament disruptor, cytochalasin B, inhibited the FN-induced enhancement of the scavenger receptor activity, suggesting that these cytoskeletal structures are required for transmission of the adhesion signal of FN.	Colchicine	25-35	fibronectin 1	Mus musculus	100-102
11279163-1	2001	Plating suspended Swiss 3T3 cells onto fibronectin-coated dishes promoted phosphorylation of endogenous focal adhesion kinase (FAK) at Tyr-397, the major autophosphorylation site, and at Tyr-577, located in the activation loop, as revealed by site-specific antibodies that recognize the phosphorylated form of these residues.	Tyrosine	135-138	fibronectin 1	Mus musculus	39-50
11399059-9	2001	The IEC adhesion to FN was inhibited by specific antibody against the FN receptor (VLA-5), as well as competitive Arg-Gly-Asp (RGD) peptide.	Arginine	114-117	fibronectin 1	Mus musculus	20-22
11399059-9	2001	The IEC adhesion to FN was inhibited by specific antibody against the FN receptor (VLA-5), as well as competitive Arg-Gly-Asp (RGD) peptide.	Glycine	118-121	fibronectin 1	Mus musculus	20-22
11399059-9	2001	The IEC adhesion to FN was inhibited by specific antibody against the FN receptor (VLA-5), as well as competitive Arg-Gly-Asp (RGD) peptide.	Aspartic Acid	122-125	fibronectin 1	Mus musculus	20-22
11399059-11	2001	Further, preincubation of IECs with an optimal concentration of genistein resulted in the inhibition of SCF-induced c-kit phosphorylation and adhesion of IECs to FN.	Genistein	64-73	fibronectin 1	Mus musculus	162-164
11279163-1	2001	Plating suspended Swiss 3T3 cells onto fibronectin-coated dishes promoted phosphorylation of endogenous focal adhesion kinase (FAK) at Tyr-397, the major autophosphorylation site, and at Tyr-577, located in the activation loop, as revealed by site-specific antibodies that recognize the phosphorylated form of these residues.	Tyrosine	187-190	fibronectin 1	Mus musculus	39-50
11279163-2	2001	Treatment with the selective Src family kinase inhibitor pyrazolopyrimidine 2 (PP-2) markedly reduced the phosphorylation of both Tyr-397 and Tyr-577 induced by fibronectin.	GW811168X	57-77	fibronectin 1	Mus musculus	161-172
11279163-2	2001	Treatment with the selective Src family kinase inhibitor pyrazolopyrimidine 2 (PP-2) markedly reduced the phosphorylation of both Tyr-397 and Tyr-577 induced by fibronectin.	pp2	79-83	fibronectin 1	Mus musculus	161-172
11279163-2	2001	Treatment with the selective Src family kinase inhibitor pyrazolopyrimidine 2 (PP-2) markedly reduced the phosphorylation of both Tyr-397 and Tyr-577 induced by fibronectin.	Tyrosine	130-133	fibronectin 1	Mus musculus	161-172
11279163-2	2001	Treatment with the selective Src family kinase inhibitor pyrazolopyrimidine 2 (PP-2) markedly reduced the phosphorylation of both Tyr-397 and Tyr-577 induced by fibronectin.	Tyrosine	142-145	fibronectin 1	Mus musculus	161-172
11279163-3	2001	Furthermore, fibronectin-mediated FAK phosphorylation at Tyr-397 was dramatically reduced in SYF cells (deficient in Src, Yes, and Fyn expression).	Tyrosine	57-60	fibronectin 1	Mus musculus	13-24
11331971-6	2001	In addition retinoic acid increased the production of hLAMP-1 and fibronectin but not transferrin, confirming our earlier report.	Tretinoin	12-25	fibronectin 1	Mus musculus	66-77
11278453-16	2001	Likewise, in 32Dcl3 myeloblast cells, CalDAG-GEF Ia expression increases cell adherence to fibronectin in response to PMA and calcium ionophore and allows higher saturation densities and prolonged growth on fibronectin-coated plates.	Calcium	126-133	fibronectin 1	Mus musculus	91-102
11336783-0	2001	Involvement of calcium signaling in the fibronectin-stimulated macrophage recognition of oxidatively damaged erythrocytes.	Calcium	15-22	fibronectin 1	Mus musculus	40-51
11336783-4	2001	Monolayers of thioglycollate-induced mouse peritoneal macrophages with cell surface fibronectin recognized autologous erythrocytes oxidized with an iron catalyst ADP/Fe(3+).	Thioglycolates	14-28	fibronectin 1	Mus musculus	84-95
11336783-4	2001	Monolayers of thioglycollate-induced mouse peritoneal macrophages with cell surface fibronectin recognized autologous erythrocytes oxidized with an iron catalyst ADP/Fe(3+).	Iron	148-152	fibronectin 1	Mus musculus	84-95
11336783-4	2001	Monolayers of thioglycollate-induced mouse peritoneal macrophages with cell surface fibronectin recognized autologous erythrocytes oxidized with an iron catalyst ADP/Fe(3+).	Adenosine Diphosphate	162-165	fibronectin 1	Mus musculus	84-95
11336783-4	2001	Monolayers of thioglycollate-induced mouse peritoneal macrophages with cell surface fibronectin recognized autologous erythrocytes oxidized with an iron catalyst ADP/Fe(3+).	Iron	166-168	fibronectin 1	Mus musculus	84-95
11336783-11	2001	Involvement of microfilament formation and arachidonate cascade in the fibronectin stimulation was also suggested.	Arachidonic Acid	43-55	fibronectin 1	Mus musculus	71-82
11313921-5	2001	In this study we demonstrate that the tyrosine phosphorylation-dependent effect of c-Cbl on adhesion of v-Abl-transformed fibroblasts is primarily mediated by an increase in fibronectin matrix deposition by these cells.	Tyrosine	38-46	fibronectin 1	Mus musculus	174-185
11357506-3	2001	Here we show that scFv(L19), a recombinant human antibody fragment with sub-nanomolar affinity for the ED-B domain of fibronectin, a marker of angiogenesis, can be stably labelled with iodine-125 and astatine-211 with full retention of immunoreactivity, using a trimethyl-stannyl benzoate bifunctional derivative.	Astatine	200-208	fibronectin 1	Mus musculus	118-129
11357506-3	2001	Here we show that scFv(L19), a recombinant human antibody fragment with sub-nanomolar affinity for the ED-B domain of fibronectin, a marker of angiogenesis, can be stably labelled with iodine-125 and astatine-211 with full retention of immunoreactivity, using a trimethyl-stannyl benzoate bifunctional derivative.	trimethyl-stannyl benzoate	262-288	fibronectin 1	Mus musculus	118-129
10787408-6	2000	Tyrosine-phosphorylated p130(cas) from fibronectin-stimulated NIH3T3 cells bound to RPTPalpha-D1-C433S as well, suggesting that p130(cas) is a physiological substrate of RPTPalpha.	Tyrosine	0-8	fibronectin 1	Mus musculus	39-50
11124936-5	2001	In 32D cells, Rap1 was also activated by phorbol 12-myristate 13-acetate and ionomycin, which also enhanced cell adhesion to fibronectin, whereas, an inhibitor of phospholipase C, inhibited both cytokine-induced activation of Rap1 and cell adhesion.	Tetradecanoylphorbol Acetate	41-72	fibronectin 1	Mus musculus	125-136
11124936-5	2001	In 32D cells, Rap1 was also activated by phorbol 12-myristate 13-acetate and ionomycin, which also enhanced cell adhesion to fibronectin, whereas, an inhibitor of phospholipase C, inhibited both cytokine-induced activation of Rap1 and cell adhesion.	Ionomycin	77-86	fibronectin 1	Mus musculus	125-136
11035040-0	2001	Altered processing of fibronectin in mice lacking heparin.	Heparin	50-57	fibronectin 1	Mus musculus	22-33
11035040-10	2001	Further experiments showed that the degradation of fibronectin observed in cell cultures from NDST-2(+/+) mice was catalyzed by mast cell chymase in a strongly heparin-dependent manner.	Heparin	160-167	fibronectin 1	Mus musculus	51-62
11746506-5	2001	Third, EGCG significantly inhibited the spread of B16-F3m cells on fibronectin, laminin, collagen, and Matrigel in a dose-dependent manner.	epigallocatechin gallate	7-11	fibronectin 1	Mus musculus	67-78
11357506-3	2001	Here we show that scFv(L19), a recombinant human antibody fragment with sub-nanomolar affinity for the ED-B domain of fibronectin, a marker of angiogenesis, can be stably labelled with iodine-125 and astatine-211 with full retention of immunoreactivity, using a trimethyl-stannyl benzoate bifunctional derivative.	Iodine	185-191	fibronectin 1	Mus musculus	118-129
11394717-7	2001	TGF-beta1 expression is accompanied by collagen and fibronectin production in asbestos-exposed animals.	Asbestos	78-86	fibronectin 1	Mus musculus	52-63
11056520-3	2000	We show here that Pyk2 is highly expressed in peritoneal IC-21 macrophage and is tyrosine phosphorylated in response to cell attachment to fibronectin and fibrinogen.	Tyrosine	81-89	fibronectin 1	Mus musculus	139-150
10966494-6	2000	Glomerular expressions of transforming growth factor-beta and fibronectin were increased with hypertrophy and were significantly suppressed in BNP-Tg.	Thioguanine	147-149	fibronectin 1	Mus musculus	62-73
10931187-0	2000	Echistatin inhibits pp125FAK autophosphorylation, paxillin phosphorylation and pp125FAK-paxillin interaction in fibronectin-adherent melanoma cells.	echistatin	0-10	fibronectin 1	Mus musculus	112-123
10931187-2	2000	The aim of this study was to establish the sequence of events downstream pp125FAK dephosphorylation that could be responsible for echistatin-induced disassembly of actin cytoskeleton and focal adhesions in fibronectin-adherent B16-BL6 melanoma cells.	echistatin	130-140	fibronectin 1	Mus musculus	206-217
10679674-4	2000	Among these four materials, the cells on collagen-coated polystyrene have the highest cell adhesive shear strength and cell detachment surface energy (1500 Pa and 29 pJ on average, respectively), followed by the cells on fibronectin-coated polystyrene (1000 Pa and 16 pJ, respectively).	Polystyrenes	240-251	fibronectin 1	Mus musculus	221-232
10852711-0	2000	Interaction with heparin and matrix metalloproteinase 2 cleavage expose a cryptic anti-adhesive site of fibronectin.	Heparin	17-24	fibronectin 1	Mus musculus	104-115
10852711-1	2000	We recently found that fibronectin (FN) had a functional site [YTIYVIAL sequence in the heparin-binding domain 2 (Hep 2)] that was capable of suppressing the integrin-mediated cell adhesion to extracellular matrix.	Heparin	88-95	fibronectin 1	Mus musculus	23-34
10852711-1	2000	We recently found that fibronectin (FN) had a functional site [YTIYVIAL sequence in the heparin-binding domain 2 (Hep 2)] that was capable of suppressing the integrin-mediated cell adhesion to extracellular matrix.	Heparin	88-95	fibronectin 1	Mus musculus	36-38
10852711-7	2000	Additionally, both the urea and heparin treatments made the Hep 2 fragment and intact FN much more accessible to the polyclonal antibody (alphaIII14A), with a recognition site near the anti-adhesive site of FN.	Urea	23-27	fibronectin 1	Mus musculus	86-88
10852711-7	2000	Additionally, both the urea and heparin treatments made the Hep 2 fragment and intact FN much more accessible to the polyclonal antibody (alphaIII14A), with a recognition site near the anti-adhesive site of FN.	Urea	23-27	fibronectin 1	Mus musculus	207-209
10852711-7	2000	Additionally, both the urea and heparin treatments made the Hep 2 fragment and intact FN much more accessible to the polyclonal antibody (alphaIII14A), with a recognition site near the anti-adhesive site of FN.	Heparin	32-39	fibronectin 1	Mus musculus	86-88
10852711-7	2000	Additionally, both the urea and heparin treatments made the Hep 2 fragment and intact FN much more accessible to the polyclonal antibody (alphaIII14A), with a recognition site near the anti-adhesive site of FN.	Heparin	32-39	fibronectin 1	Mus musculus	207-209
10772816-0	2000	Participation of syndecan 2 in the induction of stress fiber formation in cooperation with integrin alpha5beta1: structural characteristics of heparan sulfate chains with avidity to COOH-terminal heparin-binding domain of fibronectin.	Heparitin Sulfate	143-158	fibronectin 1	Mus musculus	222-233
10772816-1	2000	The present study provides direct evidence that syndecan 2 participates selectively in the induction of stress fiber formation in cooperation with integrin alpha5beta1 through specific binding of its heparan sulfate side chains to the fibronectin substrate.	Heparitin Sulfate	200-215	fibronectin 1	Mus musculus	235-246
10772816-5	2000	We here report that in vitro treatment of the cells by antisense oligonucleotide for syndecan 2 resulted in a failure to form stress fibers on fibronectin substrate in association with specific suppression of its cell surface expression.	Oligonucleotides	65-80	fibronectin 1	Mus musculus	143-154
10772816-10	2000	Finally, the dodecasaccharide sample was shown to inhibit stress fiber formation, triggered by adhesion of P29 cells to a CH-271 polypeptide consisting of both the RGD cell-binding and the C-terminal heparin-binding domains of fibronectin in a fused form.	dodecasaccharide	13-29	fibronectin 1	Mus musculus	227-238
10772816-11	2000	All these results consistently suggest that syndecan 2 proteoglycan interacts with the C-terminal heparin-binding domain of fibronectin at the highly sulfated cluster(s), such as [IdoA(2OS)-GlcNS(6OS)](6) present in its heparan sulfate chains, to result in the induction of stress fiber formation in cooperation with integrin alpha5beta1.	Heparitin Sulfate	220-235	fibronectin 1	Mus musculus	124-135
10751224-7	2000	Sense ODN-treated streptozotocin-diabetic mice had 15.3% increase in kidney weight, 70% increase in alpha1(IV) collagen and 46% increase in fibronectin mRNA levels compared with nondiabetic mice.	Streptozocin	18-32	fibronectin 1	Mus musculus	140-151
10728583-4	2000	Hydroxyl groups were first oxidized with NaIO4, and then two biological molecules, namely collagen and fibronectin were immobilized by using glutaraldehyde.	Glutaral	141-155	fibronectin 1	Mus musculus	103-114
10660524-5	2000	In addition, phosphatidylinositol 4,5-bisphosphate-gelsolin prevents apoptotic progression mediated by caspase-3 in a cell-free system, and phosphatidylinositol 4,5-bisphosphate-gelsolin-caspase-9 and phosphatidylinositol 4,5-bisphosphate-gelsolin-caspase-3 complexes form in mouse embryonic fibroblasts during apoptosis induction when stimulated with fibronectin, to delay cell death.	Phosphatidylinositol 4,5-Diphosphate	13-50	fibronectin 1	Mus musculus	352-363
10660524-5	2000	In addition, phosphatidylinositol 4,5-bisphosphate-gelsolin prevents apoptotic progression mediated by caspase-3 in a cell-free system, and phosphatidylinositol 4,5-bisphosphate-gelsolin-caspase-9 and phosphatidylinositol 4,5-bisphosphate-gelsolin-caspase-3 complexes form in mouse embryonic fibroblasts during apoptosis induction when stimulated with fibronectin, to delay cell death.	Phosphatidylinositol 4,5-Diphosphate	140-177	fibronectin 1	Mus musculus	352-363
10660524-5	2000	In addition, phosphatidylinositol 4,5-bisphosphate-gelsolin prevents apoptotic progression mediated by caspase-3 in a cell-free system, and phosphatidylinositol 4,5-bisphosphate-gelsolin-caspase-9 and phosphatidylinositol 4,5-bisphosphate-gelsolin-caspase-3 complexes form in mouse embryonic fibroblasts during apoptosis induction when stimulated with fibronectin, to delay cell death.	Phosphatidylinositol 4,5-Diphosphate	140-177	fibronectin 1	Mus musculus	352-363
10645966-4	2000	In this study we have tested the effect of retinoic acid on cardiac mesenchyme formation in vitro and then tested retinoic acid treated myocyte cultures for changes in the expression of hLAMP-1, fibronectin and transferrin members of the particulate matrix that is required for mesenchyme formation.	Tretinoin	114-127	fibronectin 1	Mus musculus	195-206
10645966-8	2000	ELISA assays revealed that retinoic acid treated myocyte cultures contained significantly more hLAMP-1 and fibronectin than either normal or DMSO controls.	Tretinoin	27-40	fibronectin 1	Mus musculus	107-118
10714768-4	2000	We now show that tyrosine phosphorylation of Met in carcinoma cells is augmented by cell adhesion and spreading on fibronectin substratum.	Tyrosine	17-25	fibronectin 1	Mus musculus	115-126
10611323-4	1999	Furthermore, when expressed in NIH 3T3 cells, DFak56 both localizes to focal contacts and displays the characteristic elevation of phosphotyrosine content in response to plating the cells on fibronectin.	Phosphotyrosine	131-146	fibronectin 1	Mus musculus	191-202
10623465-9	2000	Stimulation of tyrosine phosphorylation on FAK, p130(Cas), and paxillin by adhesion via integrin alphaVbeta3 to fibronectin or vitronectin was not disturbed in GD25-beta1B cells compared to the untransfected GD25 cells, nor were any negative effects of beta1B observed on alphaVbeta3-mediated cell attachment, spreading, and actin organization, or on the cell proliferation rate.	Tyrosine	15-23	fibronectin 1	Mus musculus	112-123
10965519-3	2000	Our results showed that genistein and curcumin blocked this response in a dose-dependent manner and also inhibited the TGF-beta 1-induced synthesis of fibronectin, an early responsive gene to the growth factor.	Genistein	24-33	fibronectin 1	Mus musculus	151-162
10965519-3	2000	Our results showed that genistein and curcumin blocked this response in a dose-dependent manner and also inhibited the TGF-beta 1-induced synthesis of fibronectin, an early responsive gene to the growth factor.	Curcumin	38-46	fibronectin 1	Mus musculus	151-162
10417317-3	1999	All known fibronectin splice variants retain the two C-terminal cysteine residues essential for dimerization, but cellular and/or structural constraints appear to influence homo- and heterodimerization patterns.	Cysteine	64-72	fibronectin 1	Mus musculus	10-21
10559474-3	1999	Cytostatin inhibited tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin upon B16 cell adhesion to fibronectin.	cytostatin	0-10	fibronectin 1	Mus musculus	116-127
10559474-3	1999	Cytostatin inhibited tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin upon B16 cell adhesion to fibronectin.	Tyrosine	21-29	fibronectin 1	Mus musculus	116-127
10448062-1	1999	p130(Cas) (Cas) is an adaptor molecule which becomes tyrosine phosphorylated by v-Src- or v-Crk-triggered transformation and several physiological stimuli, such as cell attachment to fibronectin.	Tyrosine	53-61	fibronectin 1	Mus musculus	183-194
10448062-5	1999	In addition, when plated on fibronectin-coated dishes, Cas-deficient cells exhibited a significant delay in cell spreading as compared with Cas-re-expressing cells albeit that protein-tyrosine phosphorylation was similarly induced.	Tyrosine	184-192	fibronectin 1	Mus musculus	28-39
10383637-4	1999	This responsive mechanism appears to be common to various cell types expressing disialogangliosides as: (i) disialogangliosides interfered with the inhibition of cell adhesion of different neural and non-neural cells on substrata containing TN-R and FN or RGD-containing FN fragments.	sialogangliosides	108-127	fibronectin 1	Mus musculus	250-252
10383637-4	1999	This responsive mechanism appears to be common to various cell types expressing disialogangliosides as: (i) disialogangliosides interfered with the inhibition of cell adhesion of different neural and non-neural cells on substrata containing TN-R and FN or RGD-containing FN fragments.	sialogangliosides	108-127	fibronectin 1	Mus musculus	271-273
10228160-7	1999	Fibronectin-induced tyrosine phosphorylation of focal adhesion proteins, including the focal adhesion kinase FAK, was nearly eliminated in the absence of Src, Yes and Fyn.	Tyrosine	20-28	fibronectin 1	Mus musculus	0-11
10084956-4	1999	In contrast, the present study demonstrates that blastocysts exposed in culture to the same low levels of cannabinoid agonists exhibited accelerated trophoblast differentiation with respect to fibronectin-binding activity and trophoblast outgrowth.	Cannabinoids	106-117	fibronectin 1	Mus musculus	193-204
10412775-6	1999	RESULTS: Simvastatin showed a slightly suppressive effect on mRNA expression of type IV collagen and fibronectin and a slightly up-regulative effect on that of type I collagen, whereas mRNA expression of type III collagen was markedly up-regulated.	Simvastatin	9-20	fibronectin 1	Mus musculus	101-112
10092681-11	1999	However, application of anisomycin, an activator of Jun amino-terminal kinase, resulted in a lower response in cells growing on collagen compared with fibronectin.	Anisomycin	24-34	fibronectin 1	Mus musculus	151-162