PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32294204-5	2020	The apparent half-maximal inhibitory concentrations for OSTalpha/beta-mediated bile acid (5microM) transport inhibition by fidaxomicin, troglitazone sulfate and ethinyl estradiol were: 210, 334 and 1050microM, respectively, for taurochenodeoxycholate; 97.6, 333 and 337microM, respectively, for glycochenodeoxycholate; 140, 265 and 527microM, respectively, for taurocholate; 59.8, 102 and 117microM, respectively, for glycocholate.	Fidaxomicin	123-134	solute carrier family 51 subunit alpha	Homo sapiens	56-69
33844255-9	2021	Serum OST-alpha and OST-beta levels can be used as diagnostic and monitoring markers of ICP, and the inhibition of these molecules could provide therapeutic benefit in ICP by reducing the circulation of enterohepatic bile acids.	Bile Acids and Salts	217-227	solute carrier family 51 subunit alpha	Homo sapiens	6-15
32711025-2	2020	Apical sodium-dependent bile acid transporter (ASBT), an ileal Na+-dependent transporter, plays the leading role of bile acid absorption into enterocytes, where bile acids are delivered to basolateral side by ileal bile acid binding protein (IBABP) and then released by organic solute transporter OSTalpha/beta.	Bile Acids and Salts	24-33	solute carrier family 51 subunit alpha	Homo sapiens	297-310
32711025-2	2020	Apical sodium-dependent bile acid transporter (ASBT), an ileal Na+-dependent transporter, plays the leading role of bile acid absorption into enterocytes, where bile acids are delivered to basolateral side by ileal bile acid binding protein (IBABP) and then released by organic solute transporter OSTalpha/beta.	Bile Acids and Salts	161-171	solute carrier family 51 subunit alpha	Homo sapiens	297-310
32294204-5	2020	The apparent half-maximal inhibitory concentrations for OSTalpha/beta-mediated bile acid (5microM) transport inhibition by fidaxomicin, troglitazone sulfate and ethinyl estradiol were: 210, 334 and 1050microM, respectively, for taurochenodeoxycholate; 97.6, 333 and 337microM, respectively, for glycochenodeoxycholate; 140, 265 and 527microM, respectively, for taurocholate; 59.8, 102 and 117microM, respectively, for glycocholate.	troglitazone sulfate	136-156	solute carrier family 51 subunit alpha	Homo sapiens	56-69
32294204-5	2020	The apparent half-maximal inhibitory concentrations for OSTalpha/beta-mediated bile acid (5microM) transport inhibition by fidaxomicin, troglitazone sulfate and ethinyl estradiol were: 210, 334 and 1050microM, respectively, for taurochenodeoxycholate; 97.6, 333 and 337microM, respectively, for glycochenodeoxycholate; 140, 265 and 527microM, respectively, for taurocholate; 59.8, 102 and 117microM, respectively, for glycocholate.	Ethinyl Estradiol	161-178	solute carrier family 51 subunit alpha	Homo sapiens	56-69
32294204-5	2020	The apparent half-maximal inhibitory concentrations for OSTalpha/beta-mediated bile acid (5microM) transport inhibition by fidaxomicin, troglitazone sulfate and ethinyl estradiol were: 210, 334 and 1050microM, respectively, for taurochenodeoxycholate; 97.6, 333 and 337microM, respectively, for glycochenodeoxycholate; 140, 265 and 527microM, respectively, for taurocholate; 59.8, 102 and 117microM, respectively, for glycocholate.	Taurochenodeoxycholic Acid	228-250	solute carrier family 51 subunit alpha	Homo sapiens	56-69
32294204-5	2020	The apparent half-maximal inhibitory concentrations for OSTalpha/beta-mediated bile acid (5microM) transport inhibition by fidaxomicin, troglitazone sulfate and ethinyl estradiol were: 210, 334 and 1050microM, respectively, for taurochenodeoxycholate; 97.6, 333 and 337microM, respectively, for glycochenodeoxycholate; 140, 265 and 527microM, respectively, for taurocholate; 59.8, 102 and 117microM, respectively, for glycocholate.	Glycochenodeoxycholic Acid	295-317	solute carrier family 51 subunit alpha	Homo sapiens	56-69
32294204-5	2020	The apparent half-maximal inhibitory concentrations for OSTalpha/beta-mediated bile acid (5microM) transport inhibition by fidaxomicin, troglitazone sulfate and ethinyl estradiol were: 210, 334 and 1050microM, respectively, for taurochenodeoxycholate; 97.6, 333 and 337microM, respectively, for glycochenodeoxycholate; 140, 265 and 527microM, respectively, for taurocholate; 59.8, 102 and 117microM, respectively, for glycocholate.	Taurocholic Acid	361-373	solute carrier family 51 subunit alpha	Homo sapiens	56-69
32294204-5	2020	The apparent half-maximal inhibitory concentrations for OSTalpha/beta-mediated bile acid (5microM) transport inhibition by fidaxomicin, troglitazone sulfate and ethinyl estradiol were: 210, 334 and 1050microM, respectively, for taurochenodeoxycholate; 97.6, 333 and 337microM, respectively, for glycochenodeoxycholate; 140, 265 and 527microM, respectively, for taurocholate; 59.8, 102 and 117microM, respectively, for glycocholate.	Glycocholic Acid	418-430	solute carrier family 51 subunit alpha	Homo sapiens	56-69
32294204-6	2020	The potential role of OSTalpha/beta in hepatocellular glycine-conjugated bile acid accumulation and cholestatic DILI was evaluated using sandwich-cultured human hepatocytes (SCHH).	Bile Acids and Salts	73-82	solute carrier family 51 subunit alpha	Homo sapiens	22-35
32294204-7	2020	Treatment of SCHH with the farnesoid X receptor agonist chenodeoxycholate (100microM) resulted in substantial OSTalpha/beta induction, among other proteomic alterations, reducing glycochenodeoxycholate and glycocholate accumulation in cells+bile 4.0-fold and 4.5-fold, respectively.	Chenodeoxycholic Acid	56-73	solute carrier family 51 subunit alpha	Homo sapiens	110-123
32294204-7	2020	Treatment of SCHH with the farnesoid X receptor agonist chenodeoxycholate (100microM) resulted in substantial OSTalpha/beta induction, among other proteomic alterations, reducing glycochenodeoxycholate and glycocholate accumulation in cells+bile 4.0-fold and 4.5-fold, respectively.	Glycochenodeoxycholic Acid	179-201	solute carrier family 51 subunit alpha	Homo sapiens	110-123
32294204-7	2020	Treatment of SCHH with the farnesoid X receptor agonist chenodeoxycholate (100microM) resulted in substantial OSTalpha/beta induction, among other proteomic alterations, reducing glycochenodeoxycholate and glycocholate accumulation in cells+bile 4.0-fold and 4.5-fold, respectively.	Glycocholic Acid	206-218	solute carrier family 51 subunit alpha	Homo sapiens	110-123
32294204-8	2020	Treatment of SCHH with troglitazone and fidaxomicin together under cholestatic conditions resulted in increased hepatocellular toxicity compared to either compound alone, suggesting that OSTalpha/beta inhibition may accentuate DILI.	Troglitazone	23-35	solute carrier family 51 subunit alpha	Homo sapiens	187-200
32294204-8	2020	Treatment of SCHH with troglitazone and fidaxomicin together under cholestatic conditions resulted in increased hepatocellular toxicity compared to either compound alone, suggesting that OSTalpha/beta inhibition may accentuate DILI.	Fidaxomicin	40-51	solute carrier family 51 subunit alpha	Homo sapiens	187-200
32294204-9	2020	In conclusion, this study provides insights into the role of OSTalpha/beta in preferential disposition of bile acids associated with hepatotoxicity, the impact of xenobiotics on OSTalpha/beta-mediated bile acid transport, and the role of this transporter in SCHH and cholestatic DILI.	Bile Acids and Salts	106-116	solute carrier family 51 subunit alpha	Homo sapiens	61-74
32294204-9	2020	In conclusion, this study provides insights into the role of OSTalpha/beta in preferential disposition of bile acids associated with hepatotoxicity, the impact of xenobiotics on OSTalpha/beta-mediated bile acid transport, and the role of this transporter in SCHH and cholestatic DILI.	Bile Acids and Salts	106-115	solute carrier family 51 subunit alpha	Homo sapiens	61-74
29487110-10	2018	Increased basolateral efflux of TCA was consistent with increased OSTalpha/beta protein expression in OCA- and CDCA-treated SCHH.	Taurocholic Acid	32-35	solute carrier family 51 subunit alpha	Homo sapiens	66-79
32294204-0	2020	Role of Organic Solute Transporter Alpha/Beta in Hepatotoxic Bile Acid Transport and Drug Interactions.	Bile Acids and Salts	61-70	solute carrier family 51 subunit alpha	Homo sapiens	8-40
32294204-1	2020	Organic solute transporter (OST) alpha/beta is a key bile acid transporter expressed in various organs, including the liver under cholestatic conditions.	Bile Acids and Salts	53-62	solute carrier family 51 subunit alpha	Homo sapiens	0-43
32294204-4	2020	Kinetic studies with OSTalpha/beta-overexpressing cells revealed that OSTalpha/beta preferentially transported bile acids in the following order: taurochenodeoxycholate>glycochenodeoxycholate>taurocholate>glycocholate.	Bile Acids and Salts	111-121	solute carrier family 51 subunit alpha	Homo sapiens	21-34
32294204-4	2020	Kinetic studies with OSTalpha/beta-overexpressing cells revealed that OSTalpha/beta preferentially transported bile acids in the following order: taurochenodeoxycholate>glycochenodeoxycholate>taurocholate>glycocholate.	Bile Acids and Salts	111-121	solute carrier family 51 subunit alpha	Homo sapiens	70-83
32294204-4	2020	Kinetic studies with OSTalpha/beta-overexpressing cells revealed that OSTalpha/beta preferentially transported bile acids in the following order: taurochenodeoxycholate>glycochenodeoxycholate>taurocholate>glycocholate.	Taurochenodeoxycholic Acid	146-168	solute carrier family 51 subunit alpha	Homo sapiens	70-83
32294204-4	2020	Kinetic studies with OSTalpha/beta-overexpressing cells revealed that OSTalpha/beta preferentially transported bile acids in the following order: taurochenodeoxycholate>glycochenodeoxycholate>taurocholate>glycocholate.	Glycochenodeoxycholic Acid	169-191	solute carrier family 51 subunit alpha	Homo sapiens	70-83
32294204-4	2020	Kinetic studies with OSTalpha/beta-overexpressing cells revealed that OSTalpha/beta preferentially transported bile acids in the following order: taurochenodeoxycholate>glycochenodeoxycholate>taurocholate>glycocholate.	Taurocholic Acid	192-204	solute carrier family 51 subunit alpha	Homo sapiens	70-83
32294204-4	2020	Kinetic studies with OSTalpha/beta-overexpressing cells revealed that OSTalpha/beta preferentially transported bile acids in the following order: taurochenodeoxycholate>glycochenodeoxycholate>taurocholate>glycocholate.	Glycocholic Acid	205-217	solute carrier family 51 subunit alpha	Homo sapiens	70-83
32294204-5	2020	The apparent half-maximal inhibitory concentrations for OSTalpha/beta-mediated bile acid (5microM) transport inhibition by fidaxomicin, troglitazone sulfate and ethinyl estradiol were: 210, 334 and 1050microM, respectively, for taurochenodeoxycholate; 97.6, 333 and 337microM, respectively, for glycochenodeoxycholate; 140, 265 and 527microM, respectively, for taurocholate; 59.8, 102 and 117microM, respectively, for glycocholate.	Bile Acids and Salts	79-88	solute carrier family 51 subunit alpha	Homo sapiens	56-69
31863603-1	2020	SLC51A encodes the alpha subunit of the heteromeric organic solute transporter alpha-beta (OSTalpha-OSTbeta), an important contributor to intestinal bile acid (BA) reabsorption in the enterohepatic circulation(1,2).	Bile Acids and Salts	149-158	solute carrier family 51 subunit alpha	Homo sapiens	91-99
31863603-1	2020	SLC51A encodes the alpha subunit of the heteromeric organic solute transporter alpha-beta (OSTalpha-OSTbeta), an important contributor to intestinal bile acid (BA) reabsorption in the enterohepatic circulation(1,2).	Bile Acids and Salts	160-162	solute carrier family 51 subunit alpha	Homo sapiens	0-6
31863603-1	2020	SLC51A encodes the alpha subunit of the heteromeric organic solute transporter alpha-beta (OSTalpha-OSTbeta), an important contributor to intestinal bile acid (BA) reabsorption in the enterohepatic circulation(1,2).	Bile Acids and Salts	160-162	solute carrier family 51 subunit alpha	Homo sapiens	91-99
32005758-3	2020	In this study, we found OSTbeta (Organic solute transporter beta), an important bile acid export transporter, was significantly down-regulated in CRC.	Bile Acids and Salts	80-89	solute carrier family 51 subunit alpha	Homo sapiens	24-31
30853579-0	2019	Characterization of conjugated and unconjugated bile acid transport via human organic solute transporter alpha/beta.	Bile Acids and Salts	48-57	solute carrier family 51 subunit alpha	Homo sapiens	78-110
30853579-3	2019	Organic solute transporter (OST) alpha/beta, which is known as a bidirectional transporter for some organic anions, contributes to the transport of bile acids; however, the transport properties of individual bile acids are not well understood.	Bile Acids and Salts	148-158	solute carrier family 51 subunit alpha	Homo sapiens	0-38
30853579-3	2019	Organic solute transporter (OST) alpha/beta, which is known as a bidirectional transporter for some organic anions, contributes to the transport of bile acids; however, the transport properties of individual bile acids are not well understood.	Bile Acids and Salts	208-218	solute carrier family 51 subunit alpha	Homo sapiens	0-38
30853579-7	2019	Saturable OSTalpha/beta-mediated transports of CDCA, DCA, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), glycolithocholic acid (GLCA), taurochenodeoxycholic acid (TCDCA), and taurolithocholic acid (TLCA) were observed.	Chenodeoxycholic Acid	47-51	solute carrier family 51 subunit alpha	Homo sapiens	10-18
30853579-7	2019	Saturable OSTalpha/beta-mediated transports of CDCA, DCA, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), glycolithocholic acid (GLCA), taurochenodeoxycholic acid (TCDCA), and taurolithocholic acid (TLCA) were observed.	Deoxycholic Acid	48-51	solute carrier family 51 subunit alpha	Homo sapiens	10-18
30853579-7	2019	Saturable OSTalpha/beta-mediated transports of CDCA, DCA, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), glycolithocholic acid (GLCA), taurochenodeoxycholic acid (TCDCA), and taurolithocholic acid (TLCA) were observed.	Glycochenodeoxycholic Acid	58-84	solute carrier family 51 subunit alpha	Homo sapiens	10-18
30853579-7	2019	Saturable OSTalpha/beta-mediated transports of CDCA, DCA, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), glycolithocholic acid (GLCA), taurochenodeoxycholic acid (TCDCA), and taurolithocholic acid (TLCA) were observed.	Glycochenodeoxycholic Acid	86-91	solute carrier family 51 subunit alpha	Homo sapiens	10-18
30853579-7	2019	Saturable OSTalpha/beta-mediated transports of CDCA, DCA, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), glycolithocholic acid (GLCA), taurochenodeoxycholic acid (TCDCA), and taurolithocholic acid (TLCA) were observed.	Glycodeoxycholic Acid	94-115	solute carrier family 51 subunit alpha	Homo sapiens	10-18
30853579-7	2019	Saturable OSTalpha/beta-mediated transports of CDCA, DCA, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), glycolithocholic acid (GLCA), taurochenodeoxycholic acid (TCDCA), and taurolithocholic acid (TLCA) were observed.	Glycodeoxycholic Acid	117-121	solute carrier family 51 subunit alpha	Homo sapiens	10-18
30853579-7	2019	Saturable OSTalpha/beta-mediated transports of CDCA, DCA, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), glycolithocholic acid (GLCA), taurochenodeoxycholic acid (TCDCA), and taurolithocholic acid (TLCA) were observed.	glycolithocholic acid	124-145	solute carrier family 51 subunit alpha	Homo sapiens	10-18
30853579-7	2019	Saturable OSTalpha/beta-mediated transports of CDCA, DCA, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), glycolithocholic acid (GLCA), taurochenodeoxycholic acid (TCDCA), and taurolithocholic acid (TLCA) were observed.	glycolithocholic acid	147-151	solute carrier family 51 subunit alpha	Homo sapiens	10-18
30853579-7	2019	Saturable OSTalpha/beta-mediated transports of CDCA, DCA, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), glycolithocholic acid (GLCA), taurochenodeoxycholic acid (TCDCA), and taurolithocholic acid (TLCA) were observed.	Taurochenodeoxycholic Acid	154-180	solute carrier family 51 subunit alpha	Homo sapiens	10-18
30853579-7	2019	Saturable OSTalpha/beta-mediated transports of CDCA, DCA, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), glycolithocholic acid (GLCA), taurochenodeoxycholic acid (TCDCA), and taurolithocholic acid (TLCA) were observed.	Taurochenodeoxycholic Acid	182-187	solute carrier family 51 subunit alpha	Homo sapiens	10-18
30853579-7	2019	Saturable OSTalpha/beta-mediated transports of CDCA, DCA, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), glycolithocholic acid (GLCA), taurochenodeoxycholic acid (TCDCA), and taurolithocholic acid (TLCA) were observed.	Taurolithocholic Acid	194-215	solute carrier family 51 subunit alpha	Homo sapiens	10-18
30853579-7	2019	Saturable OSTalpha/beta-mediated transports of CDCA, DCA, glycochenodeoxycholic acid (GCDCA), glycodeoxycholic acid (GDCA), glycolithocholic acid (GLCA), taurochenodeoxycholic acid (TCDCA), and taurolithocholic acid (TLCA) were observed.	Taurolithocholic Acid	217-221	solute carrier family 51 subunit alpha	Homo sapiens	10-18
30853579-8	2019	The apparent Michaelis constants of CDCA, DCA, GCDCA, GDCA, GLCA, TCDCA, and TLCA for OSTalpha/beta were 23.0 +- 4.0, 14.9 +- 1.9, 864.2 +- 80.7, 586.4 +- 43.2, 12.8 +- 0.5, 723.7 +- 4.8, and 23.9 +- 0.3 muM, respectively.	Chenodeoxycholic Acid	36-40	solute carrier family 51 subunit alpha	Homo sapiens	86-99
30853579-8	2019	The apparent Michaelis constants of CDCA, DCA, GCDCA, GDCA, GLCA, TCDCA, and TLCA for OSTalpha/beta were 23.0 +- 4.0, 14.9 +- 1.9, 864.2 +- 80.7, 586.4 +- 43.2, 12.8 +- 0.5, 723.7 +- 4.8, and 23.9 +- 0.3 muM, respectively.	Deoxycholic Acid	37-40	solute carrier family 51 subunit alpha	Homo sapiens	86-99
30853579-8	2019	The apparent Michaelis constants of CDCA, DCA, GCDCA, GDCA, GLCA, TCDCA, and TLCA for OSTalpha/beta were 23.0 +- 4.0, 14.9 +- 1.9, 864.2 +- 80.7, 586.4 +- 43.2, 12.8 +- 0.5, 723.7 +- 4.8, and 23.9 +- 0.3 muM, respectively.	Glycochenodeoxycholic Acid	47-52	solute carrier family 51 subunit alpha	Homo sapiens	86-99
30853579-8	2019	The apparent Michaelis constants of CDCA, DCA, GCDCA, GDCA, GLCA, TCDCA, and TLCA for OSTalpha/beta were 23.0 +- 4.0, 14.9 +- 1.9, 864.2 +- 80.7, 586.4 +- 43.2, 12.8 +- 0.5, 723.7 +- 4.8, and 23.9 +- 0.3 muM, respectively.	Glycodeoxycholic Acid	54-58	solute carrier family 51 subunit alpha	Homo sapiens	86-99
30853579-8	2019	The apparent Michaelis constants of CDCA, DCA, GCDCA, GDCA, GLCA, TCDCA, and TLCA for OSTalpha/beta were 23.0 +- 4.0, 14.9 +- 1.9, 864.2 +- 80.7, 586.4 +- 43.2, 12.8 +- 0.5, 723.7 +- 4.8, and 23.9 +- 0.3 muM, respectively.	glycolithocholic acid	60-64	solute carrier family 51 subunit alpha	Homo sapiens	86-99
30853579-8	2019	The apparent Michaelis constants of CDCA, DCA, GCDCA, GDCA, GLCA, TCDCA, and TLCA for OSTalpha/beta were 23.0 +- 4.0, 14.9 +- 1.9, 864.2 +- 80.7, 586.4 +- 43.2, 12.8 +- 0.5, 723.7 +- 4.8, and 23.9 +- 0.3 muM, respectively.	Taurochenodeoxycholic Acid	66-71	solute carrier family 51 subunit alpha	Homo sapiens	86-99
30853579-8	2019	The apparent Michaelis constants of CDCA, DCA, GCDCA, GDCA, GLCA, TCDCA, and TLCA for OSTalpha/beta were 23.0 +- 4.0, 14.9 +- 1.9, 864.2 +- 80.7, 586.4 +- 43.2, 12.8 +- 0.5, 723.7 +- 4.8, and 23.9 +- 0.3 muM, respectively.	Taurolithocholic Acid	77-81	solute carrier family 51 subunit alpha	Homo sapiens	86-99
30853579-10	2019	Our results indicate that OSTalpha/beta has a low affinity but a high capacity for transporting bile acids.	Bile Acids and Salts	96-106	solute carrier family 51 subunit alpha	Homo sapiens	26-39
30481467-5	2019	Seven compounds and one fixed-dose combination (100 muM final concentration) inhibited OSTalpha/beta-mediated dehydroepiandrosterone sulfate (DHEAS) uptake by >25%.	Dehydroepiandrosterone Sulfate	110-140	solute carrier family 51 subunit alpha	Homo sapiens	87-100
30481467-5	2019	Seven compounds and one fixed-dose combination (100 muM final concentration) inhibited OSTalpha/beta-mediated dehydroepiandrosterone sulfate (DHEAS) uptake by >25%.	Dehydroepiandrosterone Sulfate	142-147	solute carrier family 51 subunit alpha	Homo sapiens	87-100
30481467-6	2019	Concentration-dependent OSTalpha/beta inhibition was evaluated for all putative inhibitors (atorvastatin, ethinylestradiol, fidaxomicin, glycochenodeoxycholate, norgestimate, troglitazone, and troglitazone sulfate).	Atorvastatin	92-104	solute carrier family 51 subunit alpha	Homo sapiens	24-37
30481467-6	2019	Concentration-dependent OSTalpha/beta inhibition was evaluated for all putative inhibitors (atorvastatin, ethinylestradiol, fidaxomicin, glycochenodeoxycholate, norgestimate, troglitazone, and troglitazone sulfate).	Glycochenodeoxycholic Acid	137-159	solute carrier family 51 subunit alpha	Homo sapiens	24-37
31571170-5	2019	The role played by bile acid transport proteins (e.g., ASBT and OST-alpha/beta) is included in the discussion.	Bile Acids and Salts	19-28	solute carrier family 51 subunit alpha	Homo sapiens	64-73
28898457-3	2018	Another major transporter involved in the intestinal reclamation of bile acids is the heteromeric organic solute transporter alpha-beta (OSTalpha-OSTbeta; SLC51A-SLC51B), which exports bile acid across the basolateral membrane.	Bile Acids and Salts	68-78	solute carrier family 51 subunit alpha	Homo sapiens	137-145
28898457-3	2018	Another major transporter involved in the intestinal reclamation of bile acids is the heteromeric organic solute transporter alpha-beta (OSTalpha-OSTbeta; SLC51A-SLC51B), which exports bile acid across the basolateral membrane.	Bile Acids and Salts	68-78	solute carrier family 51 subunit alpha	Homo sapiens	155-161
28898457-3	2018	Another major transporter involved in the intestinal reclamation of bile acids is the heteromeric organic solute transporter alpha-beta (OSTalpha-OSTbeta; SLC51A-SLC51B), which exports bile acid across the basolateral membrane.	Bile Acids and Salts	68-77	solute carrier family 51 subunit alpha	Homo sapiens	137-145
28898457-3	2018	Another major transporter involved in the intestinal reclamation of bile acids is the heteromeric organic solute transporter alpha-beta (OSTalpha-OSTbeta; SLC51A-SLC51B), which exports bile acid across the basolateral membrane.	Bile Acids and Salts	68-77	solute carrier family 51 subunit alpha	Homo sapiens	155-161
28898457-8	2018	These studies underscore OSTalpha-OSTbeta"s key role in the enterohepatic circulation of bile acids in humans.	Bile Acids and Salts	89-99	solute carrier family 51 subunit alpha	Homo sapiens	25-33
29420067-6	2018	The effect of bile acids and drugs, including those associated with cholestatic drug-induced liver injury, on OSTalpha/beta-mediated transport was evaluated.	Bile Acids and Salts	14-24	solute carrier family 51 subunit alpha	Homo sapiens	110-118
29420067-8	2018	Studies in the novel cell-based system showed rapid and linear OSTalpha/beta-mediated transport for all tested compounds: dehydroepiandrosterone sulfate, digoxin, estrone sulfate, and taurocholate.	Dehydroepiandrosterone Sulfate	122-152	solute carrier family 51 subunit alpha	Homo sapiens	63-71
29420067-8	2018	Studies in the novel cell-based system showed rapid and linear OSTalpha/beta-mediated transport for all tested compounds: dehydroepiandrosterone sulfate, digoxin, estrone sulfate, and taurocholate.	Digoxin	154-161	solute carrier family 51 subunit alpha	Homo sapiens	63-71
29420067-8	2018	Studies in the novel cell-based system showed rapid and linear OSTalpha/beta-mediated transport for all tested compounds: dehydroepiandrosterone sulfate, digoxin, estrone sulfate, and taurocholate.	estrone sulfate	163-178	solute carrier family 51 subunit alpha	Homo sapiens	63-71
29420067-8	2018	Studies in the novel cell-based system showed rapid and linear OSTalpha/beta-mediated transport for all tested compounds: dehydroepiandrosterone sulfate, digoxin, estrone sulfate, and taurocholate.	Taurocholic Acid	184-196	solute carrier family 51 subunit alpha	Homo sapiens	63-71
29420067-9	2018	The interaction study with 26 compounds revealed novel OSTalpha/beta inhibitors: a biomarker for cholestasis, glycochenodeoxycholic acid; the major metabolite of troglitazone, troglitazone sulfate; and a macrocyclic antibiotic, fidaxomicin.	Glycochenodeoxycholic Acid	110-136	solute carrier family 51 subunit alpha	Homo sapiens	55-68
29420067-9	2018	The interaction study with 26 compounds revealed novel OSTalpha/beta inhibitors: a biomarker for cholestasis, glycochenodeoxycholic acid; the major metabolite of troglitazone, troglitazone sulfate; and a macrocyclic antibiotic, fidaxomicin.	Troglitazone	162-174	solute carrier family 51 subunit alpha	Homo sapiens	55-68
29420067-9	2018	The interaction study with 26 compounds revealed novel OSTalpha/beta inhibitors: a biomarker for cholestasis, glycochenodeoxycholic acid; the major metabolite of troglitazone, troglitazone sulfate; and a macrocyclic antibiotic, fidaxomicin.	troglitazone sulfate	176-196	solute carrier family 51 subunit alpha	Homo sapiens	55-68
29420067-9	2018	The interaction study with 26 compounds revealed novel OSTalpha/beta inhibitors: a biomarker for cholestasis, glycochenodeoxycholic acid; the major metabolite of troglitazone, troglitazone sulfate; and a macrocyclic antibiotic, fidaxomicin.	Fidaxomicin	228-239	solute carrier family 51 subunit alpha	Homo sapiens	55-68
29420067-10	2018	Additionally, some drugs (e.g., digoxin) consistently stimulated taurocholate uptake in OSTalpha/beta-overexpressing cells.	Digoxin	32-39	solute carrier family 51 subunit alpha	Homo sapiens	88-101
29420067-10	2018	Additionally, some drugs (e.g., digoxin) consistently stimulated taurocholate uptake in OSTalpha/beta-overexpressing cells.	Taurocholic Acid	65-77	solute carrier family 51 subunit alpha	Homo sapiens	88-101
29420067-11	2018	Our findings demonstrate that OSTalpha/beta is an important transporter in liver disease and imply a role for this transporter in bile acid-bile acid and drug-bile acid interactions, as well as cholestatic drug-induced liver injury.	Bile Acids and Salts	130-139	solute carrier family 51 subunit alpha	Homo sapiens	30-43
29420067-11	2018	Our findings demonstrate that OSTalpha/beta is an important transporter in liver disease and imply a role for this transporter in bile acid-bile acid and drug-bile acid interactions, as well as cholestatic drug-induced liver injury.	Bile Acids and Salts	140-149	solute carrier family 51 subunit alpha	Homo sapiens	30-43
29420067-11	2018	Our findings demonstrate that OSTalpha/beta is an important transporter in liver disease and imply a role for this transporter in bile acid-bile acid and drug-bile acid interactions, as well as cholestatic drug-induced liver injury.	Bile Acids and Salts	140-149	solute carrier family 51 subunit alpha	Homo sapiens	30-43
29420067-12	2018	NEW & NOTEWORTHY The organic solute transporter OSTalpha/beta is highly expressed in hepatocytes of liver tissue obtained from patients with nonalcoholic steatohepatitis and primary biliary cholangitis.	Adenosine Monophosphate	5-8	solute carrier family 51 subunit alpha	Homo sapiens	52-65
29420067-15	2018	These data suggest that hepatic OSTalpha/beta plays an essential role in patients with cholestasis and may have important clinical implications for bile acid and drug disposition.	Bile Acids and Salts	148-157	solute carrier family 51 subunit alpha	Homo sapiens	32-45
32247663-1	2020	Organic solute transporter alpha/beta (OSTalpha/beta) is a heteromeric solute carrier protein that transports bile acids, steroid metabolites and drugs into and out of cells.	Bile Acids and Salts	110-120	solute carrier family 51 subunit alpha	Homo sapiens	0-37
32247663-1	2020	Organic solute transporter alpha/beta (OSTalpha/beta) is a heteromeric solute carrier protein that transports bile acids, steroid metabolites and drugs into and out of cells.	Bile Acids and Salts	110-120	solute carrier family 51 subunit alpha	Homo sapiens	39-52
32247663-1	2020	Organic solute transporter alpha/beta (OSTalpha/beta) is a heteromeric solute carrier protein that transports bile acids, steroid metabolites and drugs into and out of cells.	Steroids	122-129	solute carrier family 51 subunit alpha	Homo sapiens	0-37
32247663-1	2020	Organic solute transporter alpha/beta (OSTalpha/beta) is a heteromeric solute carrier protein that transports bile acids, steroid metabolites and drugs into and out of cells.	Steroids	122-129	solute carrier family 51 subunit alpha	Homo sapiens	39-52
32247663-2	2020	OSTalpha/beta protein is expressed in various tissues, but its expression is highest in the gastrointestinal tract where it facilitates the recirculation of bile acids from the gut to the liver.	Bile Acids and Salts	157-167	solute carrier family 51 subunit alpha	Homo sapiens	0-13
32247663-3	2020	Previous studies established that OSTalpha/beta is upregulated in liver tissue of patients with extrahepatic cholestasis, obstructive cholestasis, and primary biliary cholangitis (PBC), conditions that are characterized by elevated bile acid concentrations in the liver and/or systemic circulation.	Bile Acids and Salts	232-241	solute carrier family 51 subunit alpha	Homo sapiens	34-47
32247663-5	2020	Since OSTalpha/beta is closely linked to the homeostasis of bile acids, and tightly regulated by the nuclear receptor farnesoid X receptor (FXR), OSTalpha/beta is a potential drug target for treatment of cholestatic liver disease, and other bile acid-related metabolic disorders such as obesity and diabetes.	Bile Acids and Salts	60-70	solute carrier family 51 subunit alpha	Homo sapiens	6-19
32247663-5	2020	Since OSTalpha/beta is closely linked to the homeostasis of bile acids, and tightly regulated by the nuclear receptor farnesoid X receptor (FXR), OSTalpha/beta is a potential drug target for treatment of cholestatic liver disease, and other bile acid-related metabolic disorders such as obesity and diabetes.	Bile Acids and Salts	60-70	solute carrier family 51 subunit alpha	Homo sapiens	146-159
32247663-5	2020	Since OSTalpha/beta is closely linked to the homeostasis of bile acids, and tightly regulated by the nuclear receptor farnesoid X receptor (FXR), OSTalpha/beta is a potential drug target for treatment of cholestatic liver disease, and other bile acid-related metabolic disorders such as obesity and diabetes.	Bile Acids and Salts	60-69	solute carrier family 51 subunit alpha	Homo sapiens	6-19
32247663-5	2020	Since OSTalpha/beta is closely linked to the homeostasis of bile acids, and tightly regulated by the nuclear receptor farnesoid X receptor (FXR), OSTalpha/beta is a potential drug target for treatment of cholestatic liver disease, and other bile acid-related metabolic disorders such as obesity and diabetes.	Bile Acids and Salts	60-69	solute carrier family 51 subunit alpha	Homo sapiens	146-159
32247663-6	2020	Obeticholic acid, a semi-synthetic bile acid used to treat PBC, under review for the treatment of NASH, and in development for the treatment of other metabolic disorders, induces OSTalpha/beta.	obeticholic acid	0-16	solute carrier family 51 subunit alpha	Homo sapiens	179-192
32247663-6	2020	Obeticholic acid, a semi-synthetic bile acid used to treat PBC, under review for the treatment of NASH, and in development for the treatment of other metabolic disorders, induces OSTalpha/beta.	Bile Acids and Salts	35-44	solute carrier family 51 subunit alpha	Homo sapiens	179-192
31863603-1	2020	SLC51A encodes the alpha subunit of the heteromeric organic solute transporter alpha-beta (OSTalpha-OSTbeta), an important contributor to intestinal bile acid (BA) reabsorption in the enterohepatic circulation(1,2).	Bile Acids and Salts	149-158	solute carrier family 51 subunit alpha	Homo sapiens	0-6
32316603-12	2020	Both human OST complexes, OST-A (with STT3A) and OST-B (containing STT3B), are involved in the N-linked glycosylation of proteins in the ER.	Nitrogen	95-96	solute carrier family 51 subunit alpha	Homo sapiens	26-31
31894354-7	2020	Moreover, as low as 0.01 muM EPI upregulated the expression of key BA synthesis genes (CYP7A1, by 65% and CYP8B1, by 67%) and BA transporters (NTCP, OSTA and BSEP), and downregulated FGF19.	epi	29-32	solute carrier family 51 subunit alpha	Homo sapiens	149-153
31175181-5	2019	As mithramycin affects cellular response to bile acid treatment by altering the expression of multiple bile transporters (e.g., ABCB4, ABCB11, sodium/taurocholate cotransporting polypeptide, organic solute transporter alpha/beta) in several cell lines [Huh7, HepaRG, HepaRG BSEP (-/-)] and primary human hepatocytes, we hypothesized that mithramycin inhibited bile-mediated activation of the farnesoid X receptor (FXR).	Plicamycin	3-14	solute carrier family 51 subunit alpha	Homo sapiens	191-223
31175181-5	2019	As mithramycin affects cellular response to bile acid treatment by altering the expression of multiple bile transporters (e.g., ABCB4, ABCB11, sodium/taurocholate cotransporting polypeptide, organic solute transporter alpha/beta) in several cell lines [Huh7, HepaRG, HepaRG BSEP (-/-)] and primary human hepatocytes, we hypothesized that mithramycin inhibited bile-mediated activation of the farnesoid X receptor (FXR).	Bile Acids and Salts	44-53	solute carrier family 51 subunit alpha	Homo sapiens	191-223
30778102-7	2019	These compounds, including fluticasone, increased mRNA expression of FXR target genes OSTalpha and OSTbeta in Huh7 cells, and in most cases also of MRP2, SHP and FGF19.	Fluticasone	27-38	solute carrier family 51 subunit alpha	Homo sapiens	86-94
30778102-7	2019	These compounds, including fluticasone, increased mRNA expression of FXR target genes OSTalpha and OSTbeta in Huh7 cells, and in most cases also of MRP2, SHP and FGF19.	Fluticasone	27-38	solute carrier family 51 subunit alpha	Homo sapiens	99-106
30481467-6	2019	Concentration-dependent OSTalpha/beta inhibition was evaluated for all putative inhibitors (atorvastatin, ethinylestradiol, fidaxomicin, glycochenodeoxycholate, norgestimate, troglitazone, and troglitazone sulfate).	Troglitazone	175-187	solute carrier family 51 subunit alpha	Homo sapiens	24-37
29487110-10	2018	Increased basolateral efflux of TCA was consistent with increased OSTalpha/beta protein expression in OCA- and CDCA-treated SCHH.	Chenodeoxycholic Acid	111-115	solute carrier family 51 subunit alpha	Homo sapiens	66-79
29226620-7	2017	Glycine conjugate of OCA increased mRNA levels of FXR target genes in Caco-2 cells, FGF-19, SHP, OSTalpha/beta, and IBABP, but not ASBT, in a concentration-dependent manner, while glycine conjugate of UDCA had no effect on the expression of these genes.	Glycine	0-7	solute carrier family 51 subunit alpha	Homo sapiens	97-110
29695968-8	2018	Furthermore, a role of the organic solute transporter OSTalpha-OSTbeta (SLC51A/B) in brain DHEAS/PregS homeostasis has been proposed.	Dehydroepiandrosterone Sulfate	91-96	solute carrier family 51 subunit alpha	Homo sapiens	72-80
24703425-1	2015	BACKGROUND & AIMS: The organic solute transporters alpha and beta (OSTalpha-OSTbeta) form a heterodimeric transporter located at the basolateral membrane of intestinal epithelial cells and hepatocytes.	Adenosine Monophosphate	12-15	solute carrier family 51 subunit alpha	Homo sapiens	27-69
28805978-10	2017	The upregulation of BSEP and OSTalpha and OSTbeta, by OCA reduced the intracellular concentrations of d8 -TCA, a model bile acid, to 39.6 +- 8.9% relative to control.	d8 -tca	102-109	solute carrier family 51 subunit alpha	Homo sapiens	29-37
28805978-10	2017	The upregulation of BSEP and OSTalpha and OSTbeta, by OCA reduced the intracellular concentrations of d8 -TCA, a model bile acid, to 39.6 +- 8.9% relative to control.	Bile Acids and Salts	119-128	solute carrier family 51 subunit alpha	Homo sapiens	29-37
28455390-1	2017	Transport of bile acids across the basolateral membrane of the intestinal enterocyte is carried out by the organic solute transporter (Ost) composed of a seven-transmembrane domain (TMD) subunit (Ostalpha) and an ancillary single TMD subunit (Ostbeta).	Bile Acids and Salts	13-23	solute carrier family 51 subunit alpha	Homo sapiens	196-204
24703425-1	2015	BACKGROUND & AIMS: The organic solute transporters alpha and beta (OSTalpha-OSTbeta) form a heterodimeric transporter located at the basolateral membrane of intestinal epithelial cells and hepatocytes.	Adenosine Monophosphate	12-15	solute carrier family 51 subunit alpha	Homo sapiens	71-79
24703425-4	2015	METHODS: OSTalpha-OSTbeta expression was measured in Huh7 cells and primary human hepatocytes (PHH) exposed to chenodeoxycholic acid (CDCA), hypoxia or both.	Chenodeoxycholic Acid	111-132	solute carrier family 51 subunit alpha	Homo sapiens	9-17
24703425-4	2015	METHODS: OSTalpha-OSTbeta expression was measured in Huh7 cells and primary human hepatocytes (PHH) exposed to chenodeoxycholic acid (CDCA), hypoxia or both.	Chenodeoxycholic Acid	134-138	solute carrier family 51 subunit alpha	Homo sapiens	9-17
24703425-8	2015	Exposure of Huh7 cells or PHH to CDCA (50 muM) enhanced the effect of hypoxia on OSTalpha mRNA levels.	Chenodeoxycholic Acid	33-37	solute carrier family 51 subunit alpha	Homo sapiens	81-89
24703425-9	2015	In luciferase assays and EMSA, the inducing effect of low oxygen could be assigned to HIF-1alpha, which binds to hypoxia responsive elements (HRE) in the OSTalpha and OSTbeta gene promoters.	Oxygen	58-64	solute carrier family 51 subunit alpha	Homo sapiens	154-162
24703425-10	2015	Site-directed mutagenesis of either the predicted HRE or the bile acid responsive FXR binding site abolished inducibility of the OSTalpha promoter, indicating that both elements need to be intact for induction by hypoxia and CDCA.	Bile Acids and Salts	61-70	solute carrier family 51 subunit alpha	Homo sapiens	129-137
24703425-10	2015	Site-directed mutagenesis of either the predicted HRE or the bile acid responsive FXR binding site abolished inducibility of the OSTalpha promoter, indicating that both elements need to be intact for induction by hypoxia and CDCA.	Chenodeoxycholic Acid	225-229	solute carrier family 51 subunit alpha	Homo sapiens	129-137
24264050-1	2014	The organic solute transporter-alpha/beta (OSTalpha/beta) is a heteromeric transporter that is essential for bile acid and sterol disposition and for the enterohepatic circulation.	Bile Acids and Salts	109-118	solute carrier family 51 subunit alpha	Homo sapiens	43-56
24264050-2	2014	To better understand the mechanism underlying OST gene regulation, the effects of retinoic acid (RA) on OSTalpha/beta gene expression were investigated.	Tretinoin	97-99	solute carrier family 51 subunit alpha	Homo sapiens	104-117
24264050-2	2014	To better understand the mechanism underlying OST gene regulation, the effects of retinoic acid (RA) on OSTalpha/beta gene expression were investigated.	Tretinoin	82-95	solute carrier family 51 subunit alpha	Homo sapiens	104-117
23097745-2	2012	Physical association of hOSTalpha and beta subunits is essential for their polarized basolateral plasma membrane localization and function in the export of bile acids and steroids.	Bile Acids and Salts	156-166	solute carrier family 51 subunit alpha	Homo sapiens	24-42
22535958-3	2012	Bimolecular fluorescence complementation analysis revealed that a 25-amino acid peptide containing the Ostbeta transmembrane (TM) domain heterodimerized with Ostalpha, although the resulting complex failed to reach the plasma membrane and generate cellular [(3)H]taurocholate transport activity.	amino acid peptide	69-87	solute carrier family 51 subunit alpha	Homo sapiens	158-166
23518683-8	2013	The responses of other genes to CDCA or GCDCA (50 muM) were smaller: median increases of ileal bile acid binding protein, organic solute transporter-alpha and -beta, and short heterodimer partner were 2.4- to 4.0-fold; apical membrane sodium bile acid transporter and farnesoid X receptor (FXR) showed little change.	Chenodeoxycholic Acid	32-36	solute carrier family 51 subunit alpha	Homo sapiens	122-164
22800197-11	2012	In LS174T/R cells, GW4064 induced the expression of FGF19, SHP, OSTalpha/beta, but not MRP2 and BCRP, although the sensitivity of these cells to cisplatin was further reduced.	GW 4064	19-25	solute carrier family 51 subunit alpha	Homo sapiens	64-77
23097745-2	2012	Physical association of hOSTalpha and beta subunits is essential for their polarized basolateral plasma membrane localization and function in the export of bile acids and steroids.	Steroids	171-179	solute carrier family 51 subunit alpha	Homo sapiens	24-42
20422499-0	2010	Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis.	Bile Acids and Salts	58-67	solute carrier family 51 subunit alpha	Homo sapiens	28-36
22291955-6	2012	Exposure of HepG2 cells to theonellasterol antagonizes the effect of natural and synthetic FXR agonists on FXR-regulated genes, including SHP, OSTalpha, BSEP and MRP4.	7-hydroxytheonellasterol	27-42	solute carrier family 51 subunit alpha	Homo sapiens	143-151
21691099-1	2011	The heteromeric organic solute transporter alpha-beta (Ostalpha-Ostbeta) is expressed at relatively high levels on the basolateral membrane of enterocytes, where it plays a critical role in the intestinal absorption of bile acids and the enterohepatic circulation.	Bile Acids and Salts	219-229	solute carrier family 51 subunit alpha	Homo sapiens	55-63
21691099-2	2011	However, this transporter is also expressed in nearly all human tissues, including those that are not normally thought to be involved in bile acid homeostasis, indicating that Ostalpha-Ostbeta may have additional roles beyond bile acid transport in these other tissues, or that bile acids and their derivatives are more pervasive than currently envisioned.	Bile Acids and Salts	137-146	solute carrier family 51 subunit alpha	Homo sapiens	176-184
21691099-2	2011	However, this transporter is also expressed in nearly all human tissues, including those that are not normally thought to be involved in bile acid homeostasis, indicating that Ostalpha-Ostbeta may have additional roles beyond bile acid transport in these other tissues, or that bile acids and their derivatives are more pervasive than currently envisioned.	Bile Acids and Salts	226-235	solute carrier family 51 subunit alpha	Homo sapiens	176-184
21691099-5	2011	In addition, studies examining Ostalpha-Ostbeta substrate specificity have revealed that this transporter can also accept conjugated steroids, including some neurosteroids, and that the transporter is selectively expressed in steroidogenic cells of the brain and adrenal gland, suggesting a novel function for Ostalpha-Ostbeta.	Steroids	133-141	solute carrier family 51 subunit alpha	Homo sapiens	31-39
21691099-5	2011	In addition, studies examining Ostalpha-Ostbeta substrate specificity have revealed that this transporter can also accept conjugated steroids, including some neurosteroids, and that the transporter is selectively expressed in steroidogenic cells of the brain and adrenal gland, suggesting a novel function for Ostalpha-Ostbeta.	Steroids	133-141	solute carrier family 51 subunit alpha	Homo sapiens	310-318
21691099-6	2011	The broad tissue expression of Ostalpha-Ostbeta is also consistent with the emerging concept that bile acids and their derivatives act as signaling molecules in diverse tissues.	Bile Acids and Salts	98-108	solute carrier family 51 subunit alpha	Homo sapiens	31-39
20649839-5	2010	OSTalpha and OSTbeta proteins were also localized to the zona reticularis of human adrenal gland, the major region for DHEAS production in the periphery.	Dehydroepiandrosterone Sulfate	119-124	solute carrier family 51 subunit alpha	Homo sapiens	0-8
20548267-10	2010	In the CP-12h group, the ratios of the ASBT/ILBP, ASBT/Ostalpha and ASBT/Ostbeta expression levels were correlated with the injury severity scores of large but not small bile ducts.	cp-12h	7-13	solute carrier family 51 subunit alpha	Homo sapiens	55-63
20422499-6	2010	OSTalpha-OSTbeta is directly regulated by the bile acid sensing nuclear receptor, farnesoid X receptor (FXR).	Bile Acids and Salts	46-55	solute carrier family 51 subunit alpha	Homo sapiens	0-8
17622954-3	2007	In HepG2 cells, stigmasterol acetate (StigAc), a water-soluble Stig derivative, suppressed ligand-activated expression of FXR target genes involved in adaptation to cholestasis (i.e. BSEP, FGF-19, OSTalpha/beta).	STIGMASTEROL ACETATE	16-36	solute carrier family 51 subunit alpha	Homo sapiens	197-210
19059462-4	2009	Transfection of H295R adrenocortical cells with FXR expression vector effectively increased FXR expression levels and additional treatment with chenodeoxycholic acid (CDCA) caused a 25-fold increase in the mRNA for organic solute transporter alpha (OSTalpha), a known FXR target gene.	Chenodeoxycholic Acid	144-165	solute carrier family 51 subunit alpha	Homo sapiens	215-247
19059462-4	2009	Transfection of H295R adrenocortical cells with FXR expression vector effectively increased FXR expression levels and additional treatment with chenodeoxycholic acid (CDCA) caused a 25-fold increase in the mRNA for organic solute transporter alpha (OSTalpha), a known FXR target gene.	Chenodeoxycholic Acid	144-165	solute carrier family 51 subunit alpha	Homo sapiens	249-257
19059462-4	2009	Transfection of H295R adrenocortical cells with FXR expression vector effectively increased FXR expression levels and additional treatment with chenodeoxycholic acid (CDCA) caused a 25-fold increase in the mRNA for organic solute transporter alpha (OSTalpha), a known FXR target gene.	Chenodeoxycholic Acid	167-171	solute carrier family 51 subunit alpha	Homo sapiens	215-247
19059462-4	2009	Transfection of H295R adrenocortical cells with FXR expression vector effectively increased FXR expression levels and additional treatment with chenodeoxycholic acid (CDCA) caused a 25-fold increase in the mRNA for organic solute transporter alpha (OSTalpha), a known FXR target gene.	Chenodeoxycholic Acid	167-171	solute carrier family 51 subunit alpha	Homo sapiens	249-257
18847488-1	2008	BACKGROUND: The organic solute transporter (OSTalpha-OSTbeta) is a heteromeric transporter that is expressed on the basolateral membrane of epithelium in intestine, kidney, liver, testis and adrenal gland and facilitates efflux of bile acids and other steroid solutes.	Bile Acids and Salts	231-241	solute carrier family 51 subunit alpha	Homo sapiens	44-52
18847488-1	2008	BACKGROUND: The organic solute transporter (OSTalpha-OSTbeta) is a heteromeric transporter that is expressed on the basolateral membrane of epithelium in intestine, kidney, liver, testis and adrenal gland and facilitates efflux of bile acids and other steroid solutes.	Steroids	252-259	solute carrier family 51 subunit alpha	Homo sapiens	44-52
18847488-4	2008	RESULTS: Tunicamycin treatment demonstrated that human OSTalpha is glycosylated.	Tunicamycin	9-20	solute carrier family 51 subunit alpha	Homo sapiens	55-63
17650074-6	2007	The interaction between Ostalpha and Ostbeta was required not only for delivery of the proteins to the plasma membrane, but it increased their stability, as noted in transfected HEK-293 cells and in tissues from Ostalpha-deficient (Ostalpha-/-) mice.	ostalpha	24-32	solute carrier family 51 subunit alpha	Homo sapiens	232-244
19273238-4	2009	Collectively, the data indicate that Ost alpha-Ost beta is essential for bile acid and sterol disposition, and suggest that the carrier may be involved in human conditions related to imbalances in bile acid or lipid homeostasis.	Bile Acids and Salts	73-82	solute carrier family 51 subunit alpha	Homo sapiens	37-46
19273238-4	2009	Collectively, the data indicate that Ost alpha-Ost beta is essential for bile acid and sterol disposition, and suggest that the carrier may be involved in human conditions related to imbalances in bile acid or lipid homeostasis.	Bile Acids and Salts	197-206	solute carrier family 51 subunit alpha	Homo sapiens	37-46
17622954-3	2007	In HepG2 cells, stigmasterol acetate (StigAc), a water-soluble Stig derivative, suppressed ligand-activated expression of FXR target genes involved in adaptation to cholestasis (i.e. BSEP, FGF-19, OSTalpha/beta).	STIGMASTEROL ACETATE	38-44	solute carrier family 51 subunit alpha	Homo sapiens	197-210
17622954-3	2007	In HepG2 cells, stigmasterol acetate (StigAc), a water-soluble Stig derivative, suppressed ligand-activated expression of FXR target genes involved in adaptation to cholestasis (i.e. BSEP, FGF-19, OSTalpha/beta).	stig	38-42	solute carrier family 51 subunit alpha	Homo sapiens	197-210
16269519-0	2006	The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.	Bile Acids and Salts	25-35	solute carrier family 51 subunit alpha	Homo sapiens	63-105
17332473-1	2007	Two proteins that mediate bile acid export from the ileal enterocyte, organic solute transporter (OST)-alpha and -beta, have recently been identified.	Bile Acids and Salts	26-35	solute carrier family 51 subunit alpha	Homo sapiens	70-118
17332473-4	2007	The results demonstrated that coexpression of hOST-alpha and -beta in transfected cells resulted in a three- to fivefold increase of the initial rate of taurocholate influx or efflux compared with cells expressing each protein individually and nontransfected cells.	Taurocholic Acid	153-165	solute carrier family 51 subunit alpha	Homo sapiens	46-66
17332473-7	2007	Truncation of the amino-terminal 50 amino acid extracellular residues of hOST-alpha abolished its interaction with hOST-beta and led to an intracellular accumulation of the two proteins and to only background levels of taurocholate transport.	Taurocholic Acid	219-231	solute carrier family 51 subunit alpha	Homo sapiens	73-83
16423920-0	2006	Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.	Bile Acids and Salts	44-53	solute carrier family 51 subunit alpha	Homo sapiens	73-81
16423920-1	2006	Organic solute transporter (OSTalpha-OSTbeta) is a novel heteromeric bile acid and sterol transporter expressed at the basolateral membranes of epithelium in the ileum, kidney, and liver.	Bile Acids and Salts	69-78	solute carrier family 51 subunit alpha	Homo sapiens	28-36
16423920-5	2006	HepG2 cells treated for 24 h with chenodeoxycholic acid, a selective FXR ligand, had higher levels of OSTalpha and OSTbeta mRNA and protein.	Chenodeoxycholic Acid	34-55	solute carrier family 51 subunit alpha	Homo sapiens	102-110
16269519-3	2006	At the basolateral domain of ileal enterocytes, bile acids are extruded into portal blood by the heterodimeric organic solute transporter OSTalpha/OSTbeta.	Bile Acids and Salts	48-58	solute carrier family 51 subunit alpha	Homo sapiens	138-146
16269519-5	2006	We show here that human OSTalpha/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST genes by the nuclear bile acid receptor/farnesoid X receptor (FXR).	Bile Acids and Salts	66-76	solute carrier family 51 subunit alpha	Homo sapiens	24-32
16269519-11	2006	In conclusion, the genes encoding the human OSTalpha/OSTbeta complex are induced by bile acids and FXR.	Bile Acids and Salts	84-94	solute carrier family 51 subunit alpha	Homo sapiens	44-52
16269519-12	2006	By coordinated control of OSTalpha/OSTbeta expression, bile acids may adjust the rate of their own efflux from enterocytes in response to changes in intracellular bile acid levels.	Bile Acids and Salts	55-65	solute carrier family 51 subunit alpha	Homo sapiens	26-34
16269519-12	2006	By coordinated control of OSTalpha/OSTbeta expression, bile acids may adjust the rate of their own efflux from enterocytes in response to changes in intracellular bile acid levels.	Bile Acids and Salts	55-64	solute carrier family 51 subunit alpha	Homo sapiens	26-34
16317684-7	2005	In conclusion, the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption, the substrate selectivity of the transporter, and the facilitated diffusion transport mode collectively indicate that OSTalpha-OSTbeta is a key basolateral transporter for the reabsorption of these important steroid-derived molecules.	Bile Acids and Salts	137-146	solute carrier family 51 subunit alpha	Homo sapiens	45-53
16251721-10	2006	Finally, overexpression of human OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate and the activation of FXR target genes.	Chenodeoxycholic Acid	91-108	solute carrier family 51 subunit alpha	Homo sapiens	33-41
16317684-7	2005	In conclusion, the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption, the substrate selectivity of the transporter, and the facilitated diffusion transport mode collectively indicate that OSTalpha-OSTbeta is a key basolateral transporter for the reabsorption of these important steroid-derived molecules.	Sterols	151-157	solute carrier family 51 subunit alpha	Homo sapiens	45-53
16871660-0	2005	Modified OSTA index for referring women for DEXA measurement.	Dexa-BEAM protocol	44-48	solute carrier family 51 subunit alpha	Homo sapiens	9-13
16317684-7	2005	In conclusion, the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption, the substrate selectivity of the transporter, and the facilitated diffusion transport mode collectively indicate that OSTalpha-OSTbeta is a key basolateral transporter for the reabsorption of these important steroid-derived molecules.	Steroids	380-387	solute carrier family 51 subunit alpha	Homo sapiens	45-53
35224661-7	2022	Exposure to DON downregulates expression of the genes coding for the apical sodium-dependent bile acid transporter (ASBT), the ileal bile acid-binding protein (IBABP) and the organic solute transporter alpha (OSTalpha), and it counteracts the agonist activity of Farnesoid X receptor (FXR) agonist GW4064 on these genes.	deoxynivalenol	12-15	solute carrier family 51 subunit alpha	Homo sapiens	175-207
33031748-8	2020	rs5855544, upstream of SLC51A, was associated with higher levels of three steroid sulfates and co-localized with expression levels of SLC51A in several tissues.	Steroids	74-81	solute carrier family 51 subunit alpha	Homo sapiens	23-29
33031748-8	2020	rs5855544, upstream of SLC51A, was associated with higher levels of three steroid sulfates and co-localized with expression levels of SLC51A in several tissues.	Steroids	74-81	solute carrier family 51 subunit alpha	Homo sapiens	134-140
34767876-7	2021	Activation of NRF2 by sulforaphane also resulted in downregulation of NTCP, OSTalpha, ABCG5, CYP7A1 and CYP8B1.	sulforaphane	22-34	solute carrier family 51 subunit alpha	Homo sapiens	76-84
34599072-1	2021	Organic solute transporter alpha/beta (OSTalpha/beta; SLC51A/B) is a bidirectional bile acid transporter localized on the basolateral membrane of hepatic, intestinal, and renal epithelial cells.	Bile Acids and Salts	83-92	solute carrier family 51 subunit alpha	Homo sapiens	0-37
34599072-1	2021	Organic solute transporter alpha/beta (OSTalpha/beta; SLC51A/B) is a bidirectional bile acid transporter localized on the basolateral membrane of hepatic, intestinal, and renal epithelial cells.	Bile Acids and Salts	83-92	solute carrier family 51 subunit alpha	Homo sapiens	39-52
34599072-1	2021	Organic solute transporter alpha/beta (OSTalpha/beta; SLC51A/B) is a bidirectional bile acid transporter localized on the basolateral membrane of hepatic, intestinal, and renal epithelial cells.	Bile Acids and Salts	83-92	solute carrier family 51 subunit alpha	Homo sapiens	54-62
34599072-2	2021	OSTalpha/beta plays a critical role in intestinal bile acid reabsorption and is upregulated in hepatic diseases characterized by elevated bile acids, while genetic variants in SLC51A/B have been associated with clinical cholestasis.	Bile Acids and Salts	50-59	solute carrier family 51 subunit alpha	Homo sapiens	0-13
34599072-2	2021	OSTalpha/beta plays a critical role in intestinal bile acid reabsorption and is upregulated in hepatic diseases characterized by elevated bile acids, while genetic variants in SLC51A/B have been associated with clinical cholestasis.	Bile Acids and Salts	138-148	solute carrier family 51 subunit alpha	Homo sapiens	0-13
34599072-5	2021	The present study addressed this knowledge gap and identified amino acids in OSTalpha that are important for bile acid transport.	Bile Acids and Salts	109-118	solute carrier family 51 subunit alpha	Homo sapiens	77-85
34599072-7	2021	Out of the ten OSTalpha/beta mutants investigated, four (S228K, T229S, Q269E, Q269K) exhibited decreased (3H)-taurocholate (TCA) uptake (ratio of geometric means relative to OSTalpha/beta WT of 0.76, 0.75, 0.79, 0.13, respectively).	Tritium	106-108	solute carrier family 51 subunit alpha	Homo sapiens	15-28
34599072-7	2021	Out of the ten OSTalpha/beta mutants investigated, four (S228K, T229S, Q269E, Q269K) exhibited decreased (3H)-taurocholate (TCA) uptake (ratio of geometric means relative to OSTalpha/beta WT of 0.76, 0.75, 0.79, 0.13, respectively).	Taurocholic Acid	110-122	solute carrier family 51 subunit alpha	Homo sapiens	15-28
34599072-7	2021	Out of the ten OSTalpha/beta mutants investigated, four (S228K, T229S, Q269E, Q269K) exhibited decreased (3H)-taurocholate (TCA) uptake (ratio of geometric means relative to OSTalpha/beta WT of 0.76, 0.75, 0.79, 0.13, respectively).	Taurocholic Acid	124-127	solute carrier family 51 subunit alpha	Homo sapiens	15-28
34599072-8	2021	Three OSTalpha/beta mutants (S228K, Q269K, E305A) had reduced (3H)-TCA efflux % (ratio of geometric means relative to OSTalpha/beta WT of 0.86, 0.65, 0.79, respectively).	Tritium	63-65	solute carrier family 51 subunit alpha	Homo sapiens	6-19
34599072-8	2021	Three OSTalpha/beta mutants (S228K, Q269K, E305A) had reduced (3H)-TCA efflux % (ratio of geometric means relative to OSTalpha/beta WT of 0.86, 0.65, 0.79, respectively).	Taurocholic Acid	67-70	solute carrier family 51 subunit alpha	Homo sapiens	6-19
34599072-10	2021	In summary, we identified OSTalpha residues (Ser228, Thr229, Gln269, Glu305) in predicted transmembrane domains that affect expression of OSTalpha/beta and may influence OSTalpha/beta-mediated bile acid transport.	Bile Acids and Salts	193-202	solute carrier family 51 subunit alpha	Homo sapiens	26-34
34599072-10	2021	In summary, we identified OSTalpha residues (Ser228, Thr229, Gln269, Glu305) in predicted transmembrane domains that affect expression of OSTalpha/beta and may influence OSTalpha/beta-mediated bile acid transport.	Bile Acids and Salts	193-202	solute carrier family 51 subunit alpha	Homo sapiens	170-183
34599072-12	2021	Significance Statement OSTalpha/beta is a clinically important transporter involved in enterohepatic bile acid recycling with currently no high-resolution protein structure and limited structure-function data.	Bile Acids and Salts	101-110	solute carrier family 51 subunit alpha	Homo sapiens	23-36
34599072-13	2021	This study identified four OSTalpha amino acids (Ser228, Thr229, Gln269, Glu305) that affect expression of OSTalpha/beta and may influence OSTalpha/beta-mediated bile acid transport.	Bile Acids and Salts	162-171	solute carrier family 51 subunit alpha	Homo sapiens	27-35
34599072-13	2021	This study identified four OSTalpha amino acids (Ser228, Thr229, Gln269, Glu305) that affect expression of OSTalpha/beta and may influence OSTalpha/beta-mediated bile acid transport.	Bile Acids and Salts	162-171	solute carrier family 51 subunit alpha	Homo sapiens	139-152
12719432-5	2003	None of the proteins elicited a transport signal when expressed individually in oocytes; however, all nine OSTalpha-OSTbeta combinations (i.e. OSTalpha-OSTbeta pairs from human, mouse, or skate) generated robust estrone 3-sulfate transport activity.	3-sulfate	220-229	solute carrier family 51 subunit alpha	Homo sapiens	107-115
12719432-7	2003	Human and mouse OSTalpha-OSTbeta also were able to mediate transport of taurocholate, digoxin, and prostaglandin E2 but not of estradiol 17beta-d-glucuronide or p-aminohippurate.	Taurocholic Acid	72-84	solute carrier family 51 subunit alpha	Homo sapiens	16-24
12719432-7	2003	Human and mouse OSTalpha-OSTbeta also were able to mediate transport of taurocholate, digoxin, and prostaglandin E2 but not of estradiol 17beta-d-glucuronide or p-aminohippurate.	Digoxin	86-93	solute carrier family 51 subunit alpha	Homo sapiens	16-24
12719432-7	2003	Human and mouse OSTalpha-OSTbeta also were able to mediate transport of taurocholate, digoxin, and prostaglandin E2 but not of estradiol 17beta-d-glucuronide or p-aminohippurate.	Dinoprostone	99-115	solute carrier family 51 subunit alpha	Homo sapiens	16-24
12719432-7	2003	Human and mouse OSTalpha-OSTbeta also were able to mediate transport of taurocholate, digoxin, and prostaglandin E2 but not of estradiol 17beta-d-glucuronide or p-aminohippurate.	estradiol-17 beta-glucuronide	127-157	solute carrier family 51 subunit alpha	Homo sapiens	16-24
35224661-7	2022	Exposure to DON downregulates expression of the genes coding for the apical sodium-dependent bile acid transporter (ASBT), the ileal bile acid-binding protein (IBABP) and the organic solute transporter alpha (OSTalpha), and it counteracts the agonist activity of Farnesoid X receptor (FXR) agonist GW4064 on these genes.	deoxynivalenol	12-15	solute carrier family 51 subunit alpha	Homo sapiens	209-217
35224661-7	2022	Exposure to DON downregulates expression of the genes coding for the apical sodium-dependent bile acid transporter (ASBT), the ileal bile acid-binding protein (IBABP) and the organic solute transporter alpha (OSTalpha), and it counteracts the agonist activity of Farnesoid X receptor (FXR) agonist GW4064 on these genes.	GW 4064	298-304	solute carrier family 51 subunit alpha	Homo sapiens	175-207
35224661-7	2022	Exposure to DON downregulates expression of the genes coding for the apical sodium-dependent bile acid transporter (ASBT), the ileal bile acid-binding protein (IBABP) and the organic solute transporter alpha (OSTalpha), and it counteracts the agonist activity of Farnesoid X receptor (FXR) agonist GW4064 on these genes.	GW 4064	298-304	solute carrier family 51 subunit alpha	Homo sapiens	209-217
35462858-2	2022	Patients with deficiency of OSTalpha or OSTbeta display considerable variation in the level of bile acid malabsorption, chronic diarrhea, and signs of cholestasis.	Bile Acids and Salts	95-104	solute carrier family 51 subunit alpha	Homo sapiens	40-47
35462858-13	2022	Lay summary: Organic solute transporter (OST) subunits OSTalpha and OSTbeta together facilitate the efflux of conjugated bile acids into the portal circulation.	Bile Acids and Salts	121-131	solute carrier family 51 subunit alpha	Homo sapiens	55-63
35462858-13	2022	Lay summary: Organic solute transporter (OST) subunits OSTalpha and OSTbeta together facilitate the efflux of conjugated bile acids into the portal circulation.	Bile Acids and Salts	121-131	solute carrier family 51 subunit alpha	Homo sapiens	68-75