PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
22807119-9	2012	The regulatory role of JNK1 in PTP1B induction by a decrease in miR-122 level was strengthened by cell-based assays using isoliquiritigenin and liquiritigenin (components in Glycyrrhizae radix) as functional JNK inhibitors; JNK inhibition enabled cells to restore IR and IRS1/2 tyrosine phosphorylation and insulin signaling against tumor necrosis factor alpha, and prevented PTP1B induction.	liquiritigenin	125-139	microRNA 122	Mus musculus	64-71
24531873-3	2014	Mutant mice with knockout (KO) of the miR-122 locus developed steatohepatitis due to increased triglyceride (TG) synthesis and decreased TG secretion from hepatocytes, and eventually developed HCC.	Triglycerides	95-107	microRNA 122	Mus musculus	38-45
24531873-3	2014	Mutant mice with knockout (KO) of the miR-122 locus developed steatohepatitis due to increased triglyceride (TG) synthesis and decreased TG secretion from hepatocytes, and eventually developed HCC.	Triglycerides	109-111	microRNA 122	Mus musculus	38-45
24531873-3	2014	Mutant mice with knockout (KO) of the miR-122 locus developed steatohepatitis due to increased triglyceride (TG) synthesis and decreased TG secretion from hepatocytes, and eventually developed HCC.	Triglycerides	137-139	microRNA 122	Mus musculus	38-45
24531873-8	2014	Since cotreatment of 5-Aza-Cd and histone deacetylase inhibitor restored miR-122 expression in HCC cells, epigenetic modulation of miR-122 expression is involved in the suppression of miR-122 in HCC.	5-aza-cd	21-29	microRNA 122	Mus musculus	73-80
24531873-8	2014	Since cotreatment of 5-Aza-Cd and histone deacetylase inhibitor restored miR-122 expression in HCC cells, epigenetic modulation of miR-122 expression is involved in the suppression of miR-122 in HCC.	5-aza-cd	21-29	microRNA 122	Mus musculus	131-138
24531873-8	2014	Since cotreatment of 5-Aza-Cd and histone deacetylase inhibitor restored miR-122 expression in HCC cells, epigenetic modulation of miR-122 expression is involved in the suppression of miR-122 in HCC.	5-aza-cd	21-29	microRNA 122	Mus musculus	131-138
24385691-7	2013	RESULTS: Insertion of miR-122T specifically down-regulated transgene expression in vitro and selectively protected the miR-122-positive cells from killing by TK/GCV treatment.	Ganciclovir	161-164	microRNA 122	Mus musculus	22-29
24385691-12	2013	CONCLUSIONS: miR-122-regulated TK expression achieved effective anti-tumor effects and increased the safety of intratumoral delivery of adenovirus-mediated TK/GCV gene therapy for miR-122-deficient HCC.	Ganciclovir	159-162	microRNA 122	Mus musculus	13-20
24385691-12	2013	CONCLUSIONS: miR-122-regulated TK expression achieved effective anti-tumor effects and increased the safety of intratumoral delivery of adenovirus-mediated TK/GCV gene therapy for miR-122-deficient HCC.	Ganciclovir	159-162	microRNA 122	Mus musculus	180-187
24030710-8	2013	Further investigation showed that phosphorothioate modification contributed to long-term miR-122 inhibition by the 2"-OMe-4"-thioribonucleoside-modified AMO.	Parathion	34-50	microRNA 122	Mus musculus	89-96
24030710-8	2013	Further investigation showed that phosphorothioate modification contributed to long-term miR-122 inhibition by the 2"-OMe-4"-thioribonucleoside-modified AMO.	2"-ome-4"-thioribonucleoside	115-143	microRNA 122	Mus musculus	89-96
23498953-5	2013	High serum cholesterol caused resistance to L. donovani infection, while downregulation of miR-122 is coupled with low serum cholesterol in VL mice.	Cholesterol	125-136	microRNA 122	Mus musculus	91-98
23498953-8	2013	Conversely, restoration of miR-122 or Dicer1 levels in VL mouse liver increased serum cholesterol and reduced liver parasite burden.	Cholesterol	86-97	microRNA 122	Mus musculus	27-34
23178710-8	2013	RESULTS: miR-122 expression was significantly reduced in transactivated HSCs and in the livers of mice treated with CCl(4).	Cefaclor	116-119	microRNA 122	Mus musculus	9-16
24113455-0	2013	Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure.	Diethylnitrosamine	97-115	microRNA 122	Mus musculus	16-23
24113455-10	2013	Collectively, miR-122 depletion facilitates cystogenesis and hepatocarcinogenesis in mice on DEN challenge by up-regulating several genes involved in proliferation, growth factor signaling, neovascularization, and metastasis.	Diethylnitrosamine	93-96	microRNA 122	Mus musculus	14-21
22807119-0	2012	Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid.	licorice flavonoid	125-143	microRNA 122	Mus musculus	12-24
22807119-9	2012	The regulatory role of JNK1 in PTP1B induction by a decrease in miR-122 level was strengthened by cell-based assays using isoliquiritigenin and liquiritigenin (components in Glycyrrhizae radix) as functional JNK inhibitors; JNK inhibition enabled cells to restore IR and IRS1/2 tyrosine phosphorylation and insulin signaling against tumor necrosis factor alpha, and prevented PTP1B induction.	isoliquiritigenin	122-139	microRNA 122	Mus musculus	64-71
22807119-9	2012	The regulatory role of JNK1 in PTP1B induction by a decrease in miR-122 level was strengthened by cell-based assays using isoliquiritigenin and liquiritigenin (components in Glycyrrhizae radix) as functional JNK inhibitors; JNK inhibition enabled cells to restore IR and IRS1/2 tyrosine phosphorylation and insulin signaling against tumor necrosis factor alpha, and prevented PTP1B induction.	Tyrosine	278-286	microRNA 122	Mus musculus	64-71
22807119-10	2012	Moreover, treatment with each of the agents increased miR-122 levels and abrogated hepatic insulin resistance in mice fed a high-fat diet, causing a glucose-lowering effect.	Glucose	149-156	microRNA 122	Mus musculus	54-61
22684891-4	2012	We found that serum/plasma miR-122 correlated with alanine aminotransferase (ALT) increases in the liver damage caused by alcohol, APAP, and TLR9 (CpG)+4 (LPS) ligands.	Alcohols	122-129	microRNA 122	Mus musculus	27-34
22503922-0	2012	Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice.	Polyphenols	14-25	microRNA 122	Mus musculus	80-87
22503922-6	2012	The addition of polyphenols also resulted in changes in the expression of miR-103, miR-107 and miR-122.	Polyphenols	16-27	microRNA 122	Mus musculus	95-102
22382835-8	2012	In addition, we obtained evidence that indicates a phenobarbital-mediated decrease in miR-122, a highly abundant liver-specific miRNA, leads to the activation of the transcription factor CAR and thereby induces drug-metabolizing enzymes.	Phenobarbital	51-64	microRNA 122	Mus musculus	86-93
22388288-4	2012	rAAV producing anti-miR-122 TuD but not anti-let-7 TuD reduced serum cholesterol by >30% for 25 weeks in wild-type mice.	Cholesterol	69-80	microRNA 122	Mus musculus	20-27
22402395-8	2012	Furthermore, the results demonstrate that hepatic miR-122 and miR-125b concentrations were increased by dietary quercetin supplementation and may therefore contribute to the gene-regulatory activity of quercetin in vivo.	Quercetin	112-121	microRNA 122	Mus musculus	50-57
22402395-8	2012	Furthermore, the results demonstrate that hepatic miR-122 and miR-125b concentrations were increased by dietary quercetin supplementation and may therefore contribute to the gene-regulatory activity of quercetin in vivo.	Quercetin	202-211	microRNA 122	Mus musculus	50-57
22815988-4	2012	In the present study, it was demonstrated that phenobarbital administration to mice decreases hepatic miR-122, a liver-enriched microRNA involved in both hepatic differentiation and function.	Phenobarbital	47-60	microRNA 122	Mus musculus	102-109
21602190-5	2011	Here, we searched for miRNAs responsible for inducing liver damage in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and found that miR-101a and miR-122 are differentially downregulated by TCDD in a time-dependent manner.	Polychlorinated Dibenzodioxins	86-121	microRNA 122	Mus musculus	157-164
21763238-7	2011	Transfection of enterocytes with an antisense oligoribonucleotide against miR-122a blocked the TNF-alpha-induced increase in enterocyte expression of miR-122a, degradation of occludin mRNA, and increase in intestinal permeability.	Oligoribonucleotides	46-65	microRNA 122	Mus musculus	74-82
21763238-7	2011	Transfection of enterocytes with an antisense oligoribonucleotide against miR-122a blocked the TNF-alpha-induced increase in enterocyte expression of miR-122a, degradation of occludin mRNA, and increase in intestinal permeability.	Oligoribonucleotides	46-65	microRNA 122	Mus musculus	150-158
22045675-2	2011	Previous studies demonstrate that two liver-enriched microRNAs (miR-122 and miR-192) are promising biomarkers of acetaminophen-induced acute liver injury (APAP-ALI) in mice.	Acetaminophen	113-126	microRNA 122	Mus musculus	64-71
21602190-5	2011	Here, we searched for miRNAs responsible for inducing liver damage in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and found that miR-101a and miR-122 are differentially downregulated by TCDD in a time-dependent manner.	Polychlorinated Dibenzodioxins	123-127	microRNA 122	Mus musculus	157-164
21602190-5	2011	Here, we searched for miRNAs responsible for inducing liver damage in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and found that miR-101a and miR-122 are differentially downregulated by TCDD in a time-dependent manner.	Polychlorinated Dibenzodioxins	201-205	microRNA 122	Mus musculus	157-164
21602190-8	2011	In conclusion, this study demonstrated that TCDD dysregulates the expression of miR101a and miR122 and that COX-2, a target gene of miR101a, plays a significant role in liver damage in mice exposed to TCDD.	Polychlorinated Dibenzodioxins	44-48	microRNA 122	Mus musculus	92-98
21364282-6	2011	These data help to explain the increased Hamp mRNA levels and subsequent iron deficiency in mice with reduced miR-122 levels and establish a direct mechanistic link between miR-122 and the regulation of systemic iron metabolism.	Iron	73-77	microRNA 122	Mus musculus	110-117
21212128-5	2011	Intravenous administration of 2 mg kg(-1) chemically modified anti-miR-122 complexed with iNOP-7 resulted in 83.2 +- 3.2% specific silencing of miR-122, which was accompanied by regulating gene expression in liver and lowering of plasma cholesterol.	Cholesterol	237-248	microRNA 122	Mus musculus	67-74
21364282-0	2011	The liver-specific microRNA miR-122 controls  systemic iron homeostasis in mice.	Iron	55-59	microRNA 122	Mus musculus	28-35
21364282-2	2011	Here we show that the liver-specific microRNA miR-122 is important for regulating Hamp mRNA expression and tissue iron levels.	Iron	114-118	microRNA 122	Mus musculus	46-53
21364282-3	2011	Efficient and specific depletion of miR-122 by injection of a locked-nucleic-acid-modified (LNA-modified) anti-miR into WT mice caused systemic iron deficiency, characterized by reduced plasma and liver iron levels, mildly impaired hematopoiesis, and increased extramedullary erythropoiesis in the spleen.	Iron	144-148	microRNA 122	Mus musculus	36-43
21364282-4	2011	Moreover, miR-122 inhibition increased the amount of mRNA transcribed by genes that control systemic iron levels, such as hemochromatosis (Hfe), hemojuvelin (Hjv), bone morphogenetic protein receptor type 1A (Bmpr1a), and Hamp.	Iron	101-105	microRNA 122	Mus musculus	10-17
21212128-5	2011	Intravenous administration of 2 mg kg(-1) chemically modified anti-miR-122 complexed with iNOP-7 resulted in 83.2 +- 3.2% specific silencing of miR-122, which was accompanied by regulating gene expression in liver and lowering of plasma cholesterol.	Cholesterol	237-248	microRNA 122	Mus musculus	144-151
34071707-10	2021	The downmodulation of cardiac Cx43, Cx26 and miR-122, high pS368-Cx43 phosphorylation, cell viability and survival activation could represent some of the female adaptative/compensatory reactions to ponatinib cardiotoxicity.	ponatinib	198-207	microRNA 122	Mus musculus	45-52
16459310-2	2006	To uncover the role of the liver-specific miR-122 in the adult liver, we inhibited it in mice with a 2"-O-methoxyethyl phosphorothioate ASO.	2"-o-methoxyethyl phosphorothioate	101-135	microRNA 122	Mus musculus	42-49
16459310-3	2006	miR-122 inhibition in normal mice resulted in reduced plasma cholesterol levels, increased hepatic fatty-acid oxidation, and a decrease in hepatic fatty-acid and cholesterol synthesis rates.	Cholesterol	61-72	microRNA 122	Mus musculus	0-7
16459310-3	2006	miR-122 inhibition in normal mice resulted in reduced plasma cholesterol levels, increased hepatic fatty-acid oxidation, and a decrease in hepatic fatty-acid and cholesterol synthesis rates.	Fatty Acids	99-109	microRNA 122	Mus musculus	0-7
16459310-3	2006	miR-122 inhibition in normal mice resulted in reduced plasma cholesterol levels, increased hepatic fatty-acid oxidation, and a decrease in hepatic fatty-acid and cholesterol synthesis rates.	hepatic fatty-acid	91-109	microRNA 122	Mus musculus	0-7
16459310-3	2006	miR-122 inhibition in normal mice resulted in reduced plasma cholesterol levels, increased hepatic fatty-acid oxidation, and a decrease in hepatic fatty-acid and cholesterol synthesis rates.	Cholesterol	162-173	microRNA 122	Mus musculus	0-7
16459310-5	2006	miR-122 inhibition in a diet-induced obesity mouse model resulted in decreased plasma cholesterol levels and a significant improvement in liver steatosis, accompanied by reductions in several lipogenic genes.	Cholesterol	86-97	microRNA 122	Mus musculus	0-7
16459310-6	2006	These results implicate miR-122 as a key regulator of cholesterol and fatty-acid metabolism in the adult liver and suggest that miR-122 may be an attractive therapeutic target for metabolic disease.	Cholesterol	54-65	microRNA 122	Mus musculus	24-31
16459310-6	2006	These results implicate miR-122 as a key regulator of cholesterol and fatty-acid metabolism in the adult liver and suggest that miR-122 may be an attractive therapeutic target for metabolic disease.	Fatty Acids	70-80	microRNA 122	Mus musculus	24-31
34606978-10	2021	Mechanistically, miR-122-5p promoted angiogenesis through shifting substrate preference to fatty acids in endothelial cells, and miR-122-5p upregulated endothelial cell fatty acid utilization through targeting 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT1).	Fatty Acids	169-179	microRNA 122	Mus musculus	129-136
20582318-6	2010	Additionally, the use of an antisense oligonucleotide to knock down miR-122 in vivo resulted in significant up-regulation of both Nocturnin mRNA and protein expression in mouse liver during the night, resulting in Nocturnin rhythms with increased amplitude.	Oligonucleotides	38-53	microRNA 122	Mus musculus	68-75
19372595-4	2009	Upregulation of miR-34a and downregulation of miR-122 was found in livers of STZ-induced diabetic mice.	Streptozocin	77-80	microRNA 122	Mus musculus	46-53
18158304-1	2008	MicroRNA-122 (miR-122) is an abundant liver-specific miRNA, implicated in fatty acid and cholesterol metabolism as well as hepatitis C viral replication.	Fatty Acids	74-84	microRNA 122	Mus musculus	14-21
18158304-1	2008	MicroRNA-122 (miR-122) is an abundant liver-specific miRNA, implicated in fatty acid and cholesterol metabolism as well as hepatitis C viral replication.	Cholesterol	89-100	microRNA 122	Mus musculus	14-21
18158304-2	2008	Here, we report that a systemically administered 16-nt, unconjugated LNA (locked nucleic acid)-antimiR oligonucleotide complementary to the 5" end of miR-122 leads to specific, dose-dependent silencing of miR-122 and shows no hepatotoxicity in mice.	16-nt	49-54	microRNA 122	Mus musculus	150-157
18158304-2	2008	Here, we report that a systemically administered 16-nt, unconjugated LNA (locked nucleic acid)-antimiR oligonucleotide complementary to the 5" end of miR-122 leads to specific, dose-dependent silencing of miR-122 and shows no hepatotoxicity in mice.	16-nt	49-54	microRNA 122	Mus musculus	205-212
18158304-5	2008	Functional antagonism of miR-122 was inferred from a low cholesterol phenotype and de-repression within 24 h of 199 liver mRNAs showing significant enrichment for miR-122 seed matches in their 3" UTRs.	Cholesterol	57-68	microRNA 122	Mus musculus	25-32
33232730-9	2021	miR-122 was upregulated, particularly in the benzimidazotriazin (10mg/kg) group.	benzimidazotriazin	45-63	microRNA 122	Mus musculus	0-7
34180736-0	2021	MicroRNA-122 overexpression promotes apoptosis and tumor suppressor gene expression induced by microcystin-leucine arginine in mouse liver.	Leucine	107-114	microRNA 122	Mus musculus	0-12
34180736-3	2021	Previous studies found that the expression of miR-122 was reduced after MC-LR exposure in liver.	mc-lr	72-77	microRNA 122	Mus musculus	46-53
34180736-6	2021	Under MC-LR exposure, miR-122 agomir transfection could further increase the expressions of tumor suppressor genes and the release of cytochrome-c (Cyt-c) and decrease the expressions of Bcl-2 and Bcl-w.	mc-lr	6-11	microRNA 122	Mus musculus	22-29
34180736-7	2021	In conclusion, miR-122 reduction can mitigate MC-LR-induced apoptosis to a certain extent, which in turn, it is likely to have contributed to MC-LR-induced hepatocarcinogenesis.	mc-lr	46-51	microRNA 122	Mus musculus	15-22
34180736-7	2021	In conclusion, miR-122 reduction can mitigate MC-LR-induced apoptosis to a certain extent, which in turn, it is likely to have contributed to MC-LR-induced hepatocarcinogenesis.	mc-lr	142-147	microRNA 122	Mus musculus	15-22
35606547-10	2022	Reduced miR-122 was partially rescued by HIF-1alpha inhibitors, digoxin and 2-methoxyestradiol in aortic smooth muscle cells.	Digoxin	64-71	microRNA 122	Mus musculus	8-15
34063126-11	2021	Taken together, our results demonstrate that APAP-exposed mice submitted to a single load of hypergravity exhibited more pronounced kidney dysfunction due to increased ER stress, which may be overcome by repetitive hypergravity loads presumably due to increased production of miR-122 in the liver.	Acetaminophen	45-49	microRNA 122	Mus musculus	276-283
35606547-10	2022	Reduced miR-122 was partially rescued by HIF-1alpha inhibitors, digoxin and 2-methoxyestradiol in aortic smooth muscle cells.	2-Methoxyestradiol	76-94	microRNA 122	Mus musculus	8-15
35606547-11	2022	Digoxin-treated Fbn1mgR/mgR mice demonstrated elevated miR-122 and suppressed CCL2 and MMP12 levels in the ascending aortae, with reduced elastin fragmentation and aortic dilation.	Digoxin	0-7	microRNA 122	Mus musculus	55-62
35133835-0	2022	gamma Peptide Nucleic Acid-Based miR-122 Inhibition Rescues Vascular Endothelial Dysfunction in Mice Fed a High-Fat Diet.	Peptides	6-13	microRNA 122	Mus musculus	33-40
35338010-0	2022	microRNA-122 inhibits hepatic stellate cell proliferation and activation in vitro and represses carbon tetrachloride-induced liver cirrhosis in mice.	Carbon Tetrachloride	96-116	microRNA 122	Mus musculus	0-12
35338010-11	2022	miR-122 expression WAS reduced by 0.21-fold and serum ALT and AST levels were enhanced in mice following 8-week CCl4 induction along with increased expression of FN, alpha-SMA, and Collagen I in liver tissues, which was blocked by miR-122 overexpression.	Carbon Tetrachloride	112-116	microRNA 122	Mus musculus	0-7
35133835-3	2022	We synthesized diethylene glycol-containing gammaP-122-I and found that its systemic administration counteracted high-fat diet (HFD)-feeding-associated increase in blood and aortic miR-122 levels, impaired endothelial function, and reduced glycemic control.	diethylene glycol	15-32	microRNA 122	Mus musculus	181-188
35133835-3	2022	We synthesized diethylene glycol-containing gammaP-122-I and found that its systemic administration counteracted high-fat diet (HFD)-feeding-associated increase in blood and aortic miR-122 levels, impaired endothelial function, and reduced glycemic control.	gammap-122-i	44-56	microRNA 122	Mus musculus	181-188
33080340-3	2020	The HNF4alpha/miR-122/CCL2 pathway, identified by our previous studies to induce macrophages infiltration, is initiated by chronic mild HIO.	N-HYDROXY-N-ISOPROPYLOXAMIC ACID	136-139	microRNA 122	Mus musculus	14-21
33792566-6	2021	Transcriptional studies implicated hypoxia-inducible factor-1alpha (HIF1alpha) in the induction of miR122 and identified the oxygen-sensing prolyl hydroxylase domain 1 (PHD1) as a miR122 target.	Oxygen	125-131	microRNA 122	Mus musculus	180-186
33586729-0	2021	The polysaccharides from the Grifola frondosa fruiting body prevent lipopolysaccharide/D-galactosamine-induced acute liver injury via the miR-122-Nrf2/ARE pathways.	Polysaccharides	4-19	microRNA 122	Mus musculus	138-145
33586729-0	2021	The polysaccharides from the Grifola frondosa fruiting body prevent lipopolysaccharide/D-galactosamine-induced acute liver injury via the miR-122-Nrf2/ARE pathways.	Galactosamine	87-102	microRNA 122	Mus musculus	138-145
33924725-0	2021	The Combination of Berberine, Tocotrienols and Coffee Extracts Improves Metabolic Profile and Liver Steatosis by the Modulation of Gut Microbiota and Hepatic miR-122 and miR-34a Expression in Mice.	Berberine	19-28	microRNA 122	Mus musculus	158-165
33924725-0	2021	The Combination of Berberine, Tocotrienols and Coffee Extracts Improves Metabolic Profile and Liver Steatosis by the Modulation of Gut Microbiota and Hepatic miR-122 and miR-34a Expression in Mice.	Tocotrienols	30-42	microRNA 122	Mus musculus	158-165
33278397-3	2021	MAIN METHODS: qRT-PCR was performed to detect miR-122 expression in ApoE-/- mice and cellular EndMT model induced by H2O2.	Hydrogen Peroxide	117-121	microRNA 122	Mus musculus	46-53
33278397-11	2021	In vitro, endothelial cells acquired a spindle-shaped morphology accompanying decrease of the endothelial markers (VE-cadherin, CD31) and increase of the mesenchymal markers (Vimentin, alpha-SMA) in the presence of H2O2, which was inhibited by miR-122 inhibitor.	Hydrogen Peroxide	215-219	microRNA 122	Mus musculus	244-251
33297121-0	2021	The p53/RMRP/miR122 signaling loop promotes epithelial-mesenchymal transition during the development of silica-induced lung fibrosis by activating the notch pathway.	Silicon Dioxide	104-110	microRNA 122	Mus musculus	13-19
33297121-13	2021	CONCLUSION: Our data indicated that p53/RMRP/miR122 feedback loop might contribute to the EMT development by activating Notch pathway, which provides new sight into understanding of the complex network regulating silica-induced lung fibrosis.	Silicon Dioxide	213-219	microRNA 122	Mus musculus	45-51
33164434-0	2020	[Experimental study on improvement of alcoholic liver disease by polysaccharides from Balanophora henryi through targeting miR-122a].	Polysaccharides	65-80	microRNA 122	Mus musculus	123-131
32170997-3	2020	This study focuses on the role of miR-122 in MC-LR-induced dysregulation of hepatic iron homeostasis in C57BL/6 mice.	mc-lr	45-50	microRNA 122	Mus musculus	34-41
32450149-10	2020	RESULTS: Injection of mice with antagomiR-122 significantly reduced levels of MIR122 in plasma, liver, and white adipose tissue; in mice on a HFD, antagomiR-122 injections increased fat droplets and total triglyceride content in liver and reduced beta-oxidation and energy expenditure, resulting in significantly more weight gain than in mice given the control microRNA.	antagomir-122	32-45	microRNA 122	Mus musculus	78-84
32450149-12	2020	In mice fed a HFD or atherogenic diet, injections of RS-2982 increased hepatic levels of MIR122 precursors and reduced hepatic synthesis of triglycerides, by reducing expression of biosynthesis enzymes.	rs-2982	53-60	microRNA 122	Mus musculus	89-95
32450149-15	2020	CONCLUSIONS: We identified the compound RS-2982 as an agonist of RORA that increases expression of MIR122 in cell lines and livers of mice.	rs-2982	40-47	microRNA 122	Mus musculus	99-105
32170997-6	2020	Furthermore, miR-122 agomir pretreatment improves MC-LR induced dysregulation of hepatic iron homeostasis by arousing the related regulators and reducing the expression of Tmprss6.	mc-lr	50-55	microRNA 122	Mus musculus	13-20
32170997-7	2020	These results suggest that miR-122 agomir can prevent the accumulation of hepatic iron induced by MC-LR, which may be related to the regulation of hepcidin by BMP/SMAD and IL-6/STAT signaling pathways.	Iron	82-86	microRNA 122	Mus musculus	27-34
32170997-7	2020	These results suggest that miR-122 agomir can prevent the accumulation of hepatic iron induced by MC-LR, which may be related to the regulation of hepcidin by BMP/SMAD and IL-6/STAT signaling pathways.	mc-lr	98-103	microRNA 122	Mus musculus	27-34
29248466-6	2018	Forkhead box protein O1(FoxO1) bound to miR-122 promoter at a site around - 56 and thus promoted miR-122 promoter activity, which could be suppressed by leptin-induced phosphorylation of FoxO1 at serine 256.	Serine	196-202	microRNA 122	Mus musculus	40-47
30824230-5	2019	Furthermore, the hepatic level of miR-122 was lower in the MenSCs-treated group compared with the BMSCs-treated group (P < 0.01) and in HPL cells-treated groups in reference to undifferentiated cells-treated groups (P < 0.05).	bmscs	98-103	microRNA 122	Mus musculus	34-41
31361816-0	2019	Inhibition of Endoplasmic Reticulum Stress Attenuated Ethanol-Induced Exosomal miR-122 and Acute Liver Injury in Mice.	Ethanol	54-61	microRNA 122	Mus musculus	79-86
31361816-1	2019	AIMS: In acute alcoholic liver injury, alcohol can directly or indirectly induce endoplasmic reticulum stress (ERS) to participate in liver injury, and it is found that the expression of serum exosomal miR-122 is significantly affected.	Alcohols	15-22	microRNA 122	Mus musculus	202-209
31361816-8	2019	Moreover, PBA 150 mg/kg markedly alleviated ethanol induced elevation of hepatic and serum exosomal miR-122 and pri-miR-122 (P < 0.05).	4-phenylbutyric acid	10-13	microRNA 122	Mus musculus	100-107
31361816-8	2019	Moreover, PBA 150 mg/kg markedly alleviated ethanol induced elevation of hepatic and serum exosomal miR-122 and pri-miR-122 (P < 0.05).	4-phenylbutyric acid	10-13	microRNA 122	Mus musculus	116-123
31361816-8	2019	Moreover, PBA 150 mg/kg markedly alleviated ethanol induced elevation of hepatic and serum exosomal miR-122 and pri-miR-122 (P < 0.05).	Ethanol	44-51	microRNA 122	Mus musculus	100-107
31361816-8	2019	Moreover, PBA 150 mg/kg markedly alleviated ethanol induced elevation of hepatic and serum exosomal miR-122 and pri-miR-122 (P < 0.05).	Ethanol	44-51	microRNA 122	Mus musculus	116-123
29715465-4	2018	Here, we found that miR-122 was decreased in mouse N2A neuroblastoma (N2A) cells after oxygen-glucose deprivation (OGD) and mouse brain after transient middle cerebral artery occlusion (MCAO).	oxygen-glucose	87-101	microRNA 122	Mus musculus	20-27
32180557-0	2020	Regulation of hepatic glutamine metabolism by miR-122.	Glutamine	22-31	microRNA 122	Mus musculus	46-53
32180557-7	2020	RESULTS: The results showed that loss of miR-122 promoted glutaminolysis but suppressed gluconeogenesis in mouse livers as evident from the buildup of 13C- and/or 15N-Glu and decrease in glucose-6-phosphate (G6P) levels, respectively, in KO livers.	Carbon-13	151-154	microRNA 122	Mus musculus	41-48
32180557-7	2020	RESULTS: The results showed that loss of miR-122 promoted glutaminolysis but suppressed gluconeogenesis in mouse livers as evident from the buildup of 13C- and/or 15N-Glu and decrease in glucose-6-phosphate (G6P) levels, respectively, in KO livers.	15n-glu	163-170	microRNA 122	Mus musculus	41-48
32180557-7	2020	RESULTS: The results showed that loss of miR-122 promoted glutaminolysis but suppressed gluconeogenesis in mouse livers as evident from the buildup of 13C- and/or 15N-Glu and decrease in glucose-6-phosphate (G6P) levels, respectively, in KO livers.	Glucose	187-194	microRNA 122	Mus musculus	41-48
32180557-7	2020	RESULTS: The results showed that loss of miR-122 promoted glutaminolysis but suppressed gluconeogenesis in mouse livers as evident from the buildup of 13C- and/or 15N-Glu and decrease in glucose-6-phosphate (G6P) levels, respectively, in KO livers.	Glucose-6-Phosphate	208-211	microRNA 122	Mus musculus	41-48
32180557-10	2020	Importantly, expressions of Gls and Slc1a5 as well as glutaminase activity were suppressed in a Gln-dependent HCC (EC4) cell line transfected with miR-122 mimic that resulted in decreased 13C-Gln, 13C-a-ketoglutarate, 13C-isocitrate, and 13C-citrate levels.	Glutamine	96-99	microRNA 122	Mus musculus	147-154
32180557-10	2020	Importantly, expressions of Gls and Slc1a5 as well as glutaminase activity were suppressed in a Gln-dependent HCC (EC4) cell line transfected with miR-122 mimic that resulted in decreased 13C-Gln, 13C-a-ketoglutarate, 13C-isocitrate, and 13C-citrate levels.	13c-gln	188-195	microRNA 122	Mus musculus	147-154
32180557-10	2020	Importantly, expressions of Gls and Slc1a5 as well as glutaminase activity were suppressed in a Gln-dependent HCC (EC4) cell line transfected with miR-122 mimic that resulted in decreased 13C-Gln, 13C-a-ketoglutarate, 13C-isocitrate, and 13C-citrate levels.	13c-a-ketoglutarate	197-216	microRNA 122	Mus musculus	147-154
32180557-10	2020	Importantly, expressions of Gls and Slc1a5 as well as glutaminase activity were suppressed in a Gln-dependent HCC (EC4) cell line transfected with miR-122 mimic that resulted in decreased 13C-Gln, 13C-a-ketoglutarate, 13C-isocitrate, and 13C-citrate levels.	13c-isocitrate	218-232	microRNA 122	Mus musculus	147-154
32180557-10	2020	Importantly, expressions of Gls and Slc1a5 as well as glutaminase activity were suppressed in a Gln-dependent HCC (EC4) cell line transfected with miR-122 mimic that resulted in decreased 13C-Gln, 13C-a-ketoglutarate, 13C-isocitrate, and 13C-citrate levels.	13c-citrate	238-249	microRNA 122	Mus musculus	147-154
32180557-11	2020	In contrast, 13C-phosphoenolpyruvate and 13C-G6P levels were elevated in cells expressing ectopic miR-122, suggesting enhanced gluconeogenesis.	13c-phosphoenolpyruvate	13-36	microRNA 122	Mus musculus	98-105
32180557-11	2020	In contrast, 13C-phosphoenolpyruvate and 13C-G6P levels were elevated in cells expressing ectopic miR-122, suggesting enhanced gluconeogenesis.	13c-g6p	41-48	microRNA 122	Mus musculus	98-105
30180301-10	2019	What is more, the decreased levels of miR-122 and over-expression of hepatic HIF-1alpha could be reversed by ICAB treatment.	3,4-di-O-caffeoylquinic acid	109-113	microRNA 122	Mus musculus	38-45
30180301-11	2019	These results simultaneously confirmed that ICAB had a significant protective effect on fibrosis in NASH by inhibiting oxidative stress via Nrf2 and suppressing multiple profibrogenic factors through miR-122/HIF-1alpha signalling pathway.	3,4-di-O-caffeoylquinic acid	44-48	microRNA 122	Mus musculus	200-207
29710498-0	2018	Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122.	coptisine	0-9	microRNA 122	Mus musculus	106-113
29710498-7	2018	Hence, COP inhibited the proliferation, migration and promoted apoptosis of HCC cells; moreover, it inhibited the tumor growth in nude mice by up-regulating the expression of miR-122.	coptisine	7-10	microRNA 122	Mus musculus	175-182
29253766-0	2018	Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122.	coptisine	21-30	microRNA 122	Mus musculus	139-146
29253766-0	2018	Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122.	Galactosamine	62-66	microRNA 122	Mus musculus	139-146
29248466-6	2018	Forkhead box protein O1(FoxO1) bound to miR-122 promoter at a site around - 56 and thus promoted miR-122 promoter activity, which could be suppressed by leptin-induced phosphorylation of FoxO1 at serine 256.	Serine	196-202	microRNA 122	Mus musculus	97-104
28923593-3	2018	In miiuy croaker, miR-122 is sensitive to poly(I:C) stimulation.	Poly I-C	42-51	microRNA 122	Mus musculus	18-25
30381674-0	2018	Evaluation of miR-122 to Predict High Dose Acetaminophen-Induced Liver Injury in Mice: The Combination Uses of 5-Fluorouracil.	Acetaminophen	43-56	microRNA 122	Mus musculus	14-21
30381674-6	2018	Consequently, there was a dose-dependent increase in miR-122 after administration of APAP intraperitoneally.	Acetaminophen	85-89	microRNA 122	Mus musculus	53-60
30381674-10	2018	Further, we investigated the drug-drug interaction between APAP and 5-fluorouracil using miR-122 and ALT in mice.	Acetaminophen	59-63	microRNA 122	Mus musculus	89-96
28802563-11	2017	Circulating MIR122 entered muscle and adipose tissues of mice, reducing mRNA levels of genes involved in triglyceride synthesis.	Triglycerides	105-117	microRNA 122	Mus musculus	12-18
28987423-3	2018	We investigated whether an alcohol-induced decrease in level of MIR122 contributes to development of ALD.	Alcohols	27-34	microRNA 122	Mus musculus	64-70
28987423-12	2018	Transgenic expression of MIR122 in hepatocytes of mice with ethanol-induced liver disease and advanced fibrosis significantly reduced serum levels of alanine aminotransferase (ALT) and liver steatosis and fibrosis, compared with mice given injections of the control vector.	Ethanol	60-67	microRNA 122	Mus musculus	25-31
28987423-13	2018	Ethanol feeding reduced expression of pri-MIR122 by increasing expression of the spliced form of the transcription factor grainyhead like transcription factor 2 (GRHL2) in liver tissues from mice.	Ethanol	0-7	microRNA 122	Mus musculus	42-48
28987423-15	2018	Mice given injections of the anti-MIR122 before ethanol feeding had increased steatosis, inflammation, and serum levels of alanine aminotransferase compared with mice given a control vector.	Ethanol	48-55	microRNA 122	Mus musculus	34-40
28987423-20	2018	Expression of an anti-MIR122 worsened the severity of liver damage following ethanol feeding in mice.	Ethanol	77-84	microRNA 122	Mus musculus	22-28
28987423-21	2018	MIR122 appears to protect the liver from ethanol-induced damage by reducing levels of HIF1alpha.	Ethanol	41-48	microRNA 122	Mus musculus	0-6
28802563-3	2017	We investigated the mechanism by which free fatty acids (FFAs) regulate MIR122 expression and the effect of MIR122 on triglyceride synthesis.	Fatty Acids, Nonesterified	39-55	microRNA 122	Mus musculus	72-78
28802563-12	2017	Mice injected with an inhibitor of MIR122 and then given CL316243, accumulated triglycerides in liver and muscle tissues, and had reduced rates of beta-oxidation.	Triglycerides	79-92	microRNA 122	Mus musculus	35-41
28802563-15	2017	Strategies to reduce triglyceride levels, by increasing MIR122, might be developed for treatment of metabolic syndrome.	Triglycerides	21-33	microRNA 122	Mus musculus	56-62
28755860-8	2017	ICG clearance kinetics correlated with histological scores for acute liver damage for APAP (i.e. 3h timepoint; r=0.90, P<0.0001) and elevations in both of the mechanistic biomarkers, miR-122 (e.g. 6h timepoint; r=0.70, P=0.005) and HMGB1 (e.g. 6h timepoint; r=0.56, P=0.04).	Indocyanine Green	0-3	microRNA 122	Mus musculus	186-193
28095325-9	2017	When Ros was given with TCPOBOP, it attenuated the inhibitory effect of TCPOBOP on miR-122.	Rosiglitazone	5-8	microRNA 122	Mus musculus	83-90
28655781-0	2017	The hepatocyte-specific HNF4alpha/miR-122 pathway contributes to iron overload-mediated hepatic inflammation.	Iron	65-69	microRNA 122	Mus musculus	34-41
28655781-7	2017	In addition, both iron-dextran injection and a 3% carbonyl iron-containing diet led to upregulation of hepatic inflammation, which was associated with a significant reduction in HNF4alpha expression and its downstream target, miR-122.	Iron-Dextran Complex	18-30	microRNA 122	Mus musculus	226-233
28655781-7	2017	In addition, both iron-dextran injection and a 3% carbonyl iron-containing diet led to upregulation of hepatic inflammation, which was associated with a significant reduction in HNF4alpha expression and its downstream target, miR-122.	Iron	18-22	microRNA 122	Mus musculus	226-233
28239403-7	2017	RESULTS: In vitro analysis using liver cell line showed that palmitate could induced decrease in miR-122 and increase in miR-370 expression.	Palmitates	61-70	microRNA 122	Mus musculus	97-104
28616908-9	2017	The result of correlation analysis indicated that miR-122 and miR-192 presented a good positive correlation with the DILI-PSS ( r=0.741 3, P<0.05; r=0.788 3, P<0.01).	dili-pss	117-125	microRNA 122	Mus musculus	50-57
30090508-0	2017	Circulating levels of miR-122 increase post-mortem, particularly following lethal dosing with pentobarbital sodium: implications for pre-clinical liver injury studies.	Pentobarbital	94-114	microRNA 122	Mus musculus	22-29
30090508-5	2017	Compared to pre-cull levels there was a significant increase in serum miR-122 level in mice culled with CO2 and, to a much greater extent, in mice culled with Pentoject.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	104-107	microRNA 122	Mus musculus	70-77
30090508-6	2017	As a result, whilst the serum level of miR-122 increased in Pentoject-culled animals exposed to paracetamol, the higher level in saline-treated mice rendered this difference statistically non-significant, in contrast to findings in animals culled with CO2.	Acetaminophen	96-107	microRNA 122	Mus musculus	39-46
28239403-13	2017	The presence of fatty acids in maternal blood and milk seem to be responsible for modulating the expression of miR-122 and miR-370, which are involved in liver metabolism.	Fatty Acids	16-27	microRNA 122	Mus musculus	111-118
28095325-4	2017	In the present study, we examined if liver hyperplasia induced by a strong chemical mitogen for the liver, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), which is an agonist of NR1I3, can be repressed by NR1C3 activation through miR-122 upregulation.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	107-149	microRNA 122	Mus musculus	236-243
28095325-4	2017	In the present study, we examined if liver hyperplasia induced by a strong chemical mitogen for the liver, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), which is an agonist of NR1I3, can be repressed by NR1C3 activation through miR-122 upregulation.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	151-158	microRNA 122	Mus musculus	236-243
28095325-10	2017	Moreover, Ros treatment inhibited the NR1I3 binding with the DR1 site in the pri-miR-122 promoter.	Rosiglitazone	10-13	microRNA 122	Mus musculus	81-88
28095325-11	2017	Furthermore, the increase of miR-122 produced by Ros was correlated with the downregulation of its targets, E2f1 and cMyc.	Rosiglitazone	49-52	microRNA 122	Mus musculus	29-36
29176318-0	2017	CCL2 is Upregulated by Decreased miR-122 Expression in Iron-Overload-Induced Hepatic Inflammation.	Iron	55-59	microRNA 122	Mus musculus	33-40
27899485-6	2017	In the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT, n = 155), 12-month atorvastatin reduced circulating miR-122.	Atorvastatin	76-88	microRNA 122	Mus musculus	109-116
26171734-5	2015	It has been shown that phenobarbital-mediated activation of constitutive androstane receptor (CAR), xenobiotic nuclear receptor, is associated with a decrease in miR-122 in the liver.	Phenobarbital	23-36	microRNA 122	Mus musculus	162-169
29216638-7	2017	RESULTS: miR-122 was downregulated in free fatty acid (FFA)-induced steatotic hepatocytes, and streptozotocin and high-fat diet (STZ-HFD) induced nonalcoholic steatohepatitis (NASH) in mice.	Fatty Acids, Nonesterified	38-53	microRNA 122	Mus musculus	9-16
29216638-7	2017	RESULTS: miR-122 was downregulated in free fatty acid (FFA)-induced steatotic hepatocytes, and streptozotocin and high-fat diet (STZ-HFD) induced nonalcoholic steatohepatitis (NASH) in mice.	Fatty Acids, Nonesterified	55-58	microRNA 122	Mus musculus	9-16
29216638-8	2017	Transfection of hepatocytes with miR-122 mimics before FFA induction inhibited lipid droplet formation and TG accumulation in vitro.	Triglycerides	107-109	microRNA 122	Mus musculus	33-40
29216638-9	2017	These results were verified by overexpressing miR-122 in the livers of STZ-HFD-induced NASH mice.	Streptozocin	71-74	microRNA 122	Mus musculus	46-53
29216638-15	2017	CONCLUSIONS: The present results indicate that miR-122 plays an important role in lipid (particularly TG) accumulation in the liver by reducing YY1 mRNA stability to upregulate FXR-SHP signaling.	Triglycerides	102-104	microRNA 122	Mus musculus	47-54
27592052-0	2016	HNF-4alpha regulated miR-122 contributes to development of gluconeogenesis and lipid metabolism disorders in Type 2 diabetic mice and in palmitate-treated HepG2 cells.	Palmitates	137-146	microRNA 122	Mus musculus	21-28
27592052-7	2016	In contrast, expression of miR-122, HNF-4alpha, PEPCK, G6Pase, SREBP-1, FAS-1 and ACCalpha were significantly elevated in liver of Type 2 diabetic mice and in palmitate-treated HepG2 cells compared to controls.	Palmitates	159-168	microRNA 122	Mus musculus	27-34
27477940-10	2016	MIR122 was inhibited in mice by tail-vein injection of an oligonucleotide antagonist of MIR122.	Oligonucleotides	58-73	microRNA 122	Mus musculus	0-6
27477940-10	2016	MIR122 was inhibited in mice by tail-vein injection of an oligonucleotide antagonist of MIR122.	Oligonucleotides	58-73	microRNA 122	Mus musculus	88-94
27477940-16	2016	Injection of mice with an oligonucleotide antagonist of MIR122 increased blood levels of EPO, reticulocytes, and hemoglobin.	Oligonucleotides	26-41	microRNA 122	Mus musculus	56-62
27648358-3	2016	In the present study, we show that miR-122 confers resistance to 5-fluorouracil induced hepatocellular carcinoma cell apoptosis in vitro and reduces the potency of 5-fluorouracil in the inhibition of tumor growth in a mouse xenograft model in vivo.	Fluorouracil	65-79	microRNA 122	Mus musculus	35-42
27648358-3	2016	In the present study, we show that miR-122 confers resistance to 5-fluorouracil induced hepatocellular carcinoma cell apoptosis in vitro and reduces the potency of 5-fluorouracil in the inhibition of tumor growth in a mouse xenograft model in vivo.	Fluorouracil	164-178	microRNA 122	Mus musculus	35-42
26933995-5	2016	In addition, IL-6 and TNF-alpha levels were elevated and miR-122 levels were decreased in mouse and rat models of diethylnitrosamine (DEN)-induced HCC.	Diethylnitrosamine	114-132	microRNA 122	Mus musculus	57-64
26933995-5	2016	In addition, IL-6 and TNF-alpha levels were elevated and miR-122 levels were decreased in mouse and rat models of diethylnitrosamine (DEN)-induced HCC.	Diethylnitrosamine	134-137	microRNA 122	Mus musculus	57-64
26933995-6	2016	Restoration of miR-122 levels through delivery of agomir-122 suppressed DEN-induced hepatocarcinogenesis in mice.	Diethylnitrosamine	72-75	microRNA 122	Mus musculus	15-22
26171734-7	2015	The level of miR-122 was significantly repressed by treatment with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), which is an agonist of mouse CAR.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	67-109	microRNA 122	Mus musculus	13-20
26171734-7	2015	The level of miR-122 was significantly repressed by treatment with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), which is an agonist of mouse CAR.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	111-118	microRNA 122	Mus musculus	13-20
25826076-0	2015	Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.	Arginine	85-93	microRNA 122	Mus musculus	10-16
25909171-7	2015	Further in vivo studies disclosed that intravenous injection of miR-122-expressing lentivirus successfully increased miR-122 level and reduced the amount of collagen fibrils, FN1 and SRF in the livers of CCl4-treated mice.	Carbon Tetrachloride	204-208	microRNA 122	Mus musculus	64-71
25746479-5	2015	Here we show that chronic ethanol exposure increased intestinal miR122a expression, which decreased occludin expression leading to increased intestinal permeability.	Ethanol	26-33	microRNA 122	Mus musculus	64-71
25746479-6	2015	Moreover, LGGs supplementation decreased ethanol-elevated miR122a level and attenuated ethanol-induced liver injury in mice.	Ethanol	41-48	microRNA 122	Mus musculus	58-65
25746479-7	2015	Similar to the effect of ethanol exposure, overexpression of miR122a in Caco-2 monolayers markedly decreased occludin protein levels.	Ethanol	25-32	microRNA 122	Mus musculus	61-68
25826076-3	2015	Because deregulated amino acid levels in cancers can affect their biological behavior, we determined the amino acid levels in miR122-silenced mouse liver tissues, in which intracellular arginine levels were significantly increased.	Arginine	186-194	microRNA 122	Mus musculus	126-132
25826076-4	2015	The increased intracellular arginine levels were through upregulation of the solute carrier family 7 (SLC7A1), a transporter of arginine and a direct target of miR122.	Arginine	28-36	microRNA 122	Mus musculus	160-166
25826076-5	2015	Arginine is the substrate for nitric oxide (NO) synthetase, and intracellular NO levels were increased in miR122-silenced HCC cells, with increased resistance to sorafenib, a multikinase inhibitor.	Sorafenib	162-171	microRNA 122	Mus musculus	106-112
25826076-6	2015	Conversely, maintenance of the miR122-silenced HCC cells in arginine-depleted culture media, as well as overexpression of miR122 in miR122-low-expressing HCC cells, reversed these effects and rendered the cells more sensitive to sorafenib.	Arginine	60-68	microRNA 122	Mus musculus	31-37
25826076-6	2015	Conversely, maintenance of the miR122-silenced HCC cells in arginine-depleted culture media, as well as overexpression of miR122 in miR122-low-expressing HCC cells, reversed these effects and rendered the cells more sensitive to sorafenib.	Sorafenib	229-238	microRNA 122	Mus musculus	122-128
25826076-6	2015	Conversely, maintenance of the miR122-silenced HCC cells in arginine-depleted culture media, as well as overexpression of miR122 in miR122-low-expressing HCC cells, reversed these effects and rendered the cells more sensitive to sorafenib.	Sorafenib	229-238	microRNA 122	Mus musculus	122-128
25826076-7	2015	Using a reporter knock-in construct, chemical compounds were screened, and Wee1 kinase inhibitor was identified as upregulators of miR122 transcription, which increased the sensitivity of the cells to sorafenib.	Sorafenib	201-210	microRNA 122	Mus musculus	131-137
25826076-8	2015	These results provide an insight into sorafenib resistance in miR122-low HCC, and suggest that arginine depletion or a combination of sorafenib with the identified compound may provide promising approaches to managing this HCC subset.	Sorafenib	38-47	microRNA 122	Mus musculus	62-68
24759152-4	2014	Of them, miR-122 was mostly downregulated by cisplatin, whereas miR-34a was upregulated.	Cisplatin	45-54	microRNA 122	Mus musculus	9-16
25040043-1	2015	BACKGROUND & AIMS: miR-122 is the most abundant miRNA in the liver particularly in hepatocytes where it targets cholesterol metabolism.	Adenosine Monophosphate	12-15	microRNA 122	Mus musculus	23-30
25040043-1	2015	BACKGROUND & AIMS: miR-122 is the most abundant miRNA in the liver particularly in hepatocytes where it targets cholesterol metabolism.	Cholesterol	116-127	microRNA 122	Mus musculus	23-30
25040043-4	2015	METHODS: miR-122 and its target genes were evaluated in mouse livers and/or isolated hepatocytes after methionine-choline-deficient (MCD) or methionine-choline-supplemented (MCS) diet.	Methionine	103-113	microRNA 122	Mus musculus	9-16
25040043-4	2015	METHODS: miR-122 and its target genes were evaluated in mouse livers and/or isolated hepatocytes after methionine-choline-deficient (MCD) or methionine-choline-supplemented (MCS) diet.	methionine-choline	103-121	microRNA 122	Mus musculus	9-16
24759152-10	2014	Consistently, cisplatin facilitated the binding of Foxo3 and p53 for activation, which depended not only on decreased miR-122 but also on increased miR-34a.	Cisplatin	14-23	microRNA 122	Mus musculus	118-125
24217942-3	2014	Liver-specific microRNA-122 (miR-122) has been shown as a key regulator of cholesterol and fatty acid metabolism in adult liver, and has recently been proposed as a sensitive and specific circulating biomarker of hepatic injury.	Cholesterol	75-86	microRNA 122	Mus musculus	29-36
24217942-3	2014	Liver-specific microRNA-122 (miR-122) has been shown as a key regulator of cholesterol and fatty acid metabolism in adult liver, and has recently been proposed as a sensitive and specific circulating biomarker of hepatic injury.	Fatty Acids	91-101	microRNA 122	Mus musculus	29-36