PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34311128-3	2021	MATERIAL AND METHODS: To explore the role of OIP5-AS1 in the progression of AKI, the cisplatin-induced AKI mouse and cell model were established.	Cisplatin	85-94	Opa interacting protein 5	Homo sapiens	45-49
33820868-0	2021	Downregulation of OIP5-AS1 affects proNGF-induced pancreatic cancer metastasis by inhibiting p75NTR levels.	prongf	35-41	Opa interacting protein 5	Homo sapiens	18-22
34503297-12	2021	PLK1 inhibitor BI2356 inhibits the growth of xenografts formed by ACHN OIP5 cells.	bi2356	15-21	Opa interacting protein 5	Homo sapiens	71-75
34311128-7	2021	RESULTS: OIP5-AS1 was significantly downregulated both in cisplatin-induced AKI mice and human renal tubular cell line HK-2 cells.	Cisplatin	58-67	Opa interacting protein 5	Homo sapiens	9-13
34311128-9	2021	Furthermore, OIP5-AS1 was identified as a sponge of miR-144-5p, and upregulation of miR-144-5p could significantly reverse overexpression of OIP5-AS1-induced protective effect on the damage of cisplatin to HK-2 cells.	Cisplatin	193-202	Opa interacting protein 5	Homo sapiens	13-17
34311128-9	2021	Furthermore, OIP5-AS1 was identified as a sponge of miR-144-5p, and upregulation of miR-144-5p could significantly reverse overexpression of OIP5-AS1-induced protective effect on the damage of cisplatin to HK-2 cells.	Cisplatin	193-202	Opa interacting protein 5	Homo sapiens	141-145
32916503-15	2021	CONCLUSIONS: OIP5-AS1 knockdown suppressed the progression of breast cancer by inducing GLO1 expression via competitively binding to miR-216a-5p, suggesting that OIP5-AS1 was a hopeful biomarker for the therapy of breast cancer.	mir-216a-5p	133-144	Opa interacting protein 5	Homo sapiens	13-17
33867356-10	2021	OIP5-AS1-induced injury and apoptosis, oxidative stress and activation of NF-kappaB pathway were reversed by miR-30c-5p in ox-LDL-treated HUVECs.	mir-30c-5p	109-119	Opa interacting protein 5	Homo sapiens	0-4
33692839-11	2021	It was observed that OIP5-AS1 was upregulated in DDP-resistant OSCC cells, and the knockdown of OIP5-AS1 improved DDP sensitivity in DDP-resistant OSCC cells.	Cisplatin	49-52	Opa interacting protein 5	Homo sapiens	21-25
33692839-13	2021	Furthermore, miR-27b-3p silencing reversed the effect of OIP5-AS1 knockdown on DDP sensitivity in DDP-resistant OSCC cells.	mir-27b-3p	13-23	Opa interacting protein 5	Homo sapiens	57-61
33692839-13	2021	Furthermore, miR-27b-3p silencing reversed the effect of OIP5-AS1 knockdown on DDP sensitivity in DDP-resistant OSCC cells.	Cisplatin	79-82	Opa interacting protein 5	Homo sapiens	57-61
34132932-4	2021	Temozolomide (TMZ)-resistant GBM cells were established and transfected with relative plasmid to alter OIP5-AS1, IGF2BP2 or miR-129-5p expression.	Temozolomide	0-12	Opa interacting protein 5	Homo sapiens	103-107
34132932-4	2021	Temozolomide (TMZ)-resistant GBM cells were established and transfected with relative plasmid to alter OIP5-AS1, IGF2BP2 or miR-129-5p expression.	Temozolomide	14-17	Opa interacting protein 5	Homo sapiens	103-107
34132932-8	2021	OIP5-AS1 silencing or miR-129-5p overexpression inhibited GBM cell chemoresistance to TMZ and proliferation, and promoted cell apoptosis.	Temozolomide	86-89	Opa interacting protein 5	Homo sapiens	0-4
34132932-11	2021	CONCLUSION: OIP5-AS1 inhibition upregulated miR-129-5p to repress resistance to TMZ in GBM cells via downregulating IGF2BP2.	Temozolomide	80-83	Opa interacting protein 5	Homo sapiens	12-16
32460190-0	2020	Long noncoding RNA OIP5-AS1 mediates resistance to doxorubicin by regulating miR-137-3p/PTN axis in osteosarcoma.	Doxorubicin	51-62	Opa interacting protein 5	Homo sapiens	19-23
32706064-13	2020	CONCLUSIONS: The present study clarified that OIP5-AS1 accelerated OC progression by sponging miR-324-3p and upregulating NFIB.	mir-324-3p	94-104	Opa interacting protein 5	Homo sapiens	46-50
32308348-13	2020	Moreover, silencing OIP5-AS1 and up-regulating miR-137 expression significantly intensified growth inhibition of drug-resistant CC cells and improved the sensitivity of CC cells to L-OHP.	Oxaliplatin	181-186	Opa interacting protein 5	Homo sapiens	20-24
32460190-5	2020	Also, the knockdown of OIP5-AS1 was found to have decreased doxorubicin resistance of OS cells.	Doxorubicin	60-71	Opa interacting protein 5	Homo sapiens	23-27
32460190-7	2020	Furthermore, the loss of miR-137-3p or alternatively, the gain of PTN, both resulted in the abolishment of the inhibitory role of OIP5-AS1 silencing the proliferative activity.	mir-137-3p	25-35	Opa interacting protein 5	Homo sapiens	130-134
32410883-14	2020	MiR-27a-3p was a target of OIP5-AS1, and reversed the impact of OIP5-AS1 on MM cells.	mir-27a-3p	0-10	Opa interacting protein 5	Homo sapiens	27-31
32440152-0	2020	Long Non-Coding RNA OIP5-AS1 Knockdown Enhances CDDP Sensitivity in Osteosarcoma via miR-377-3p/FOSL2 Axis.	Cisplatin	48-52	Opa interacting protein 5	Homo sapiens	20-24
32440152-10	2020	OIP5-AS1 silencing inhibited cell viability and the IC50 value of CDDP, and promoted apoptotic rate in CDDP-resistant OS cells.	Cisplatin	66-70	Opa interacting protein 5	Homo sapiens	0-4
32440152-10	2020	OIP5-AS1 silencing inhibited cell viability and the IC50 value of CDDP, and promoted apoptotic rate in CDDP-resistant OS cells.	Cisplatin	103-107	Opa interacting protein 5	Homo sapiens	0-4
32440152-12	2020	Moreover, OIP5-AS1 knockdown repressed OS tumor growth and enhanced CDDP sensitivity of OS in vivo.	Cisplatin	68-72	Opa interacting protein 5	Homo sapiens	10-14
32308348-14	2020	OIP5-AS1 targetedly inhibited miR-137 expression, and silencing OIP5-AS1 reversed the resistance of CC cells to L-OHP by promoting the expression of miR-137.	Oxaliplatin	112-117	Opa interacting protein 5	Homo sapiens	64-68
32308348-15	2020	CONCLUSION: Highly expressed in CC, OIP5-AS1 can affect the biological behavior of CC cells, and can also regulate the resistance of CC cells to L-OHP by mediating miR-137 expression.	Oxaliplatin	145-150	Opa interacting protein 5	Homo sapiens	36-40
30588253-0	2018	OIP5 Promotes Growth, Metastasis and Chemoresistance to Cisplatin in Bladder Cancer Cells.	Cisplatin	56-65	Opa interacting protein 5	Homo sapiens	0-4
31068824-7	2019	OIP5-AS1 knockdown suppressed the proliferation, migration, and invasion of HemECs cell, while overexpression of OIP5-AS1 had opposite effects LncRNA OIP5-AS1 acted as a ceRNA through binding with miR-195-5p to upregulate NOB1 in HemECs.	CHEMBL3740941	205-207	Opa interacting protein 5	Homo sapiens	0-4
30779126-0	2019	Long noncoding RNA OIP5-AS1 acts as a competing endogenous RNA to promote glutamine catabolism and malignant melanoma growth by sponging miR-217.	Glutamine	74-83	Opa interacting protein 5	Homo sapiens	19-23
33153318-9	2020	MTT assays and analysis using the Celigo Imaging Cytometry System reveal that the silencing of OIP5 inhibits U251 cell growth.	monooxyethylene trimethylolpropane tristearate	0-3	Opa interacting protein 5	Homo sapiens	95-99
31611952-8	2019	A PPI network, composed of 44 nodes and 886 edges, was constructed, and its significant module had 16 hub genes in the whole network: Opa interacting protein 5, exonuclease 1, PCNA clamp-associated factor, checkpoint kinase 1, hyaluronan-mediated motility receptor, maternal embryonic leucine zipper kinase, non-SMC condensin I complex subunit G, centromere protein F, BUB1 mitotic checkpoint serine/threonine kinase, cyclin A2, thyroid hormone receptor interactor 13, TPX2 microtubule nucleation factor, nucleolar and spindle associated protein 1, kinesin family member 20A, aurora kinase A and centrosomal protein 55.	leucylleucine	285-292	Opa interacting protein 5	Homo sapiens	134-159
31611952-8	2019	A PPI network, composed of 44 nodes and 886 edges, was constructed, and its significant module had 16 hub genes in the whole network: Opa interacting protein 5, exonuclease 1, PCNA clamp-associated factor, checkpoint kinase 1, hyaluronan-mediated motility receptor, maternal embryonic leucine zipper kinase, non-SMC condensin I complex subunit G, centromere protein F, BUB1 mitotic checkpoint serine/threonine kinase, cyclin A2, thyroid hormone receptor interactor 13, TPX2 microtubule nucleation factor, nucleolar and spindle associated protein 1, kinesin family member 20A, aurora kinase A and centrosomal protein 55.	cholecystokinin C-terminal flanking peptide	393-399	Opa interacting protein 5	Homo sapiens	134-159
31611952-8	2019	A PPI network, composed of 44 nodes and 886 edges, was constructed, and its significant module had 16 hub genes in the whole network: Opa interacting protein 5, exonuclease 1, PCNA clamp-associated factor, checkpoint kinase 1, hyaluronan-mediated motility receptor, maternal embryonic leucine zipper kinase, non-SMC condensin I complex subunit G, centromere protein F, BUB1 mitotic checkpoint serine/threonine kinase, cyclin A2, thyroid hormone receptor interactor 13, TPX2 microtubule nucleation factor, nucleolar and spindle associated protein 1, kinesin family member 20A, aurora kinase A and centrosomal protein 55.	glycyl-threonine	400-409	Opa interacting protein 5	Homo sapiens	134-159
30588253-8	2018	Cisplatin sensitivity assay indicated that depletion of OIP5 increased the sensitivity of BC cells to cisplatin.	Cisplatin	0-9	Opa interacting protein 5	Homo sapiens	56-60
30588253-8	2018	Cisplatin sensitivity assay indicated that depletion of OIP5 increased the sensitivity of BC cells to cisplatin.	Cisplatin	102-111	Opa interacting protein 5	Homo sapiens	56-60
23664661-4	2013	Immunohistochemical analysis revealed that paraffin-embedded archival CCRCC specimens exhibited higher levels of OIP5 expression than normal renal tissues.	Paraffin	43-51	Opa interacting protein 5	Homo sapiens	113-117
30284228-0	2018	OIP5 Expression Sensitize Glioblastoma Cells to Lomustine Treatment.	Lomustine	48-57	Opa interacting protein 5	Homo sapiens	0-4
30284228-4	2018	The main goal of this study was to evaluate the OIP5 contribution to GBM tumorigenesis and assess the role of OIP5 in GBM cell response to lomustine, an alkylating agent used in the treatment of this malignancy.	Lomustine	139-148	Opa interacting protein 5	Homo sapiens	110-114
30284228-6	2018	Our results demonstrated that downregulation of the OIP5 stimulates glioma cell viability and inhibits cell death-induced necrosis prompted by lomustine.	Lomustine	143-152	Opa interacting protein 5	Homo sapiens	52-56
30284228-7	2018	In conclusion, our data shows that OIP5 expression in GBM cells seems to be able to enhance lomustine cytotoxic effects, reinforcing that this gene is a potential therapeutic target and putative molecular biomarker for treatment response in GBM.	Lomustine	92-101	Opa interacting protein 5	Homo sapiens	35-39