PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32075687-2	2020	Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of the liver X receptor (LXR) and estrogen receptor beta (ERbeta) may impact the association between 27HC and breast cancer risk.	27-hydroxycholesterol	89-93	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	41-70
32075687-0	2020	Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-beta, and ERbeta: results from the EPIC-Heidelberg cohort.	Hydroxycholesterols	15-33	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	82-88
32075687-2	2020	Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of the liver X receptor (LXR) and estrogen receptor beta (ERbeta) may impact the association between 27HC and breast cancer risk.	27-hydroxycholesterol	89-93	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	72-78
32075687-2	2020	Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of the liver X receptor (LXR) and estrogen receptor beta (ERbeta) may impact the association between 27HC and breast cancer risk.	27-hydroxycholesterol	241-245	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	72-78
31720082-0	2019	Recruitment of monocytes and epigenetic silencing of intratumoral CYP7B1 primarily contribute to the accumulation of 27-hydroxycholesterol in breast cancer.	27-hydroxycholesterol	117-138	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	66-72
31337596-0	2020	AKR1D1 and CYP7B1 mutations in patients with inborn errors of bile acid metabolism: Possibly underdiagnosed diseases.	Bile Acids and Salts	62-71	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	11-17
31337596-12	2020	The only surviving patient with oxysterol 7alpha-hydroxylase deficiency recovered from liver failure after chenodeoxycholic acid (CDCA) treatment beginning at 3 months of age.	Chenodeoxycholic Acid	107-128	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	32-60
31337596-12	2020	The only surviving patient with oxysterol 7alpha-hydroxylase deficiency recovered from liver failure after chenodeoxycholic acid (CDCA) treatment beginning at 3 months of age.	Chenodeoxycholic Acid	130-134	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	32-60
31828178-1	2019	Hereditary spastic paraplegia type 5 is a neurodegenerative disease caused by loss-of-function mutations in the CYP7B1 gene encoding the oxysterol 7-alpha-hydroxylase involved in bile acid synthesis in the liver.	Bile Acids and Salts	179-188	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	112-118
31828178-1	2019	Hereditary spastic paraplegia type 5 is a neurodegenerative disease caused by loss-of-function mutations in the CYP7B1 gene encoding the oxysterol 7-alpha-hydroxylase involved in bile acid synthesis in the liver.	Bile Acids and Salts	179-188	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	137-166
31828178-2	2019	Lack of CYP7B1 leads to an accumulation of its oxysterol substrates, in particular 25-hydroxycholesterol and 27-hydroxycholesterol that are able to cross the blood-brain barrier and have neurotoxic properties.	arthrofactin	47-56	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	8-14
31828178-2	2019	Lack of CYP7B1 leads to an accumulation of its oxysterol substrates, in particular 25-hydroxycholesterol and 27-hydroxycholesterol that are able to cross the blood-brain barrier and have neurotoxic properties.	25-hydroxycholesterol	83-104	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	8-14
31828178-2	2019	Lack of CYP7B1 leads to an accumulation of its oxysterol substrates, in particular 25-hydroxycholesterol and 27-hydroxycholesterol that are able to cross the blood-brain barrier and have neurotoxic properties.	27-hydroxycholesterol	109-130	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	8-14
31828178-5	2019	A single-dose injection of either mouse or human CYP7B1 mRNA led to a pronounced degradation of oxysterols in liver and serum within 2 days of treatment.	arthrofactin	96-106	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	49-55
31828178-6	2019	Pharmacokinetics indicate a single injection of human CYP7B1 mRNA to be effective in reducing oxysterols for at least 5 days.	arthrofactin	94-104	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	54-60
31720082-7	2019	Taken together, our data demonstrate that the hypermethylation of CYP7B1 and recruitment of monocytes likely contribute to the accumulation of 27-Hydroxycholesterol in breast cancer and that the interaction of 27-HC with macrophages further promote the development of breast cancer.	Hydroxycholesterols	146-164	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	66-72
30710743-0	2019	Mitochondrial oxysterol biosynthetic pathway gives evidence for CYP7B1 as controller of regulatory oxysterols.	Oxysterols	14-23	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	64-70
31247323-3	2019	Here we report for the first time biochemical analysis of purified human oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol.	24-hydroxycholesterol	116-137	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	73-101
30710743-3	2019	Both 26HC and 25HC have been shown to be subsequently 7alpha-hydroxylated by Cyp7b1; reducing their regulatory abilities and furthering their metabolism to chenodeoxycholic acid (CDCA).	Chenodeoxycholic Acid	156-177	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	77-83
30710743-3	2019	Both 26HC and 25HC have been shown to be subsequently 7alpha-hydroxylated by Cyp7b1; reducing their regulatory abilities and furthering their metabolism to chenodeoxycholic acid (CDCA).	Chenodeoxycholic Acid	179-183	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	77-83
32015930-5	2019	Cholesterol transport to mitochondrial sterol 27-hydroxylase (CYP27A1) by steroidogenic acute regulatory protein (StarD1), and the subsequent 7alpha-hydroxylation of oxysterols by oxysterol 7alpha-hydroxylase (CYP7B1) are the key regulatory steps of the pathway.	Cholesterol	0-11	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	210-216
32015930-5	2019	Cholesterol transport to mitochondrial sterol 27-hydroxylase (CYP27A1) by steroidogenic acute regulatory protein (StarD1), and the subsequent 7alpha-hydroxylation of oxysterols by oxysterol 7alpha-hydroxylase (CYP7B1) are the key regulatory steps of the pathway.	arthrofactin	166-176	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	180-208
32015930-5	2019	Cholesterol transport to mitochondrial sterol 27-hydroxylase (CYP27A1) by steroidogenic acute regulatory protein (StarD1), and the subsequent 7alpha-hydroxylation of oxysterols by oxysterol 7alpha-hydroxylase (CYP7B1) are the key regulatory steps of the pathway.	arthrofactin	166-176	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	210-216
32015930-6	2019	Recent observations suggest CYP7B1 to be the ultimate controller of cellular oxysterol levels.	arthrofactin	77-86	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	28-34
30710743-0	2019	Mitochondrial oxysterol biosynthetic pathway gives evidence for CYP7B1 as controller of regulatory oxysterols.	Oxysterols	99-109	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	64-70
30710743-9	2019	Just as importantly, it provides evidence for CYP7B1 as a key regulator of three vital intracellular regulatory oxysterol levels.	Oxysterols	112-121	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	46-52
30588086-9	2019	Furthermore, liver LXR/RXR signaling pathway was altered between LA and TNBC in AA women and may be due to the deficiency of the CYP7B1 enzyme responsible for cholesterol degradation.	Cholesterol	159-170	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	129-135
30742043-4	2019	We found increased mRNA expression of EBI2 and oxysterol-synthesizing enzymes (CH25H, CYP7B1) in the inflamed colon of patients with ulcerative colitis and mice with acute or chronic dextran sulfate sodium (DSS) colitis.	Dextran Sulfate	183-205	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	86-92
30586624-7	2019	In contrast the increase in levels of 27OH is likely to be a consequence of reduced metabolism due to loss of the neuronal enzyme CYP7B1.	27-hydroxycholesterol	38-42	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	130-136
29689289-1	2018	Dihydroxycholesterols such as 7alpha,25-dihydroxysterols (7alpha,25-OHC) and 7alpha,27-OHC are generated from cholesterol by the enzymes CH25H, CYP7B1 and CYP27A1 in steady state but also in the context of inflammation.	Cholesterol	9-20	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	144-150
30546280-1	2018	Oxysterol 7alpha-hydroxylase deficiency is a very rare liver disease categorized as inborn errors of bile acid synthesis, caused by CYP7B1 mutations.	Bile Acids and Salts	101-110	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	132-138
29689289-1	2018	Dihydroxycholesterols such as 7alpha,25-dihydroxysterols (7alpha,25-OHC) and 7alpha,27-OHC are generated from cholesterol by the enzymes CH25H, CYP7B1 and CYP27A1 in steady state but also in the context of inflammation.	dihydroxycholesterols	0-21	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	144-150
29689289-1	2018	Dihydroxycholesterols such as 7alpha,25-dihydroxysterols (7alpha,25-OHC) and 7alpha,27-OHC are generated from cholesterol by the enzymes CH25H, CYP7B1 and CYP27A1 in steady state but also in the context of inflammation.	7alpha,25-dihydroxysterols	30-56	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	144-150
29689289-1	2018	Dihydroxycholesterols such as 7alpha,25-dihydroxysterols (7alpha,25-OHC) and 7alpha,27-OHC are generated from cholesterol by the enzymes CH25H, CYP7B1 and CYP27A1 in steady state but also in the context of inflammation.	7alpha	30-36	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	144-150
29689289-1	2018	Dihydroxycholesterols such as 7alpha,25-dihydroxysterols (7alpha,25-OHC) and 7alpha,27-OHC are generated from cholesterol by the enzymes CH25H, CYP7B1 and CYP27A1 in steady state but also in the context of inflammation.	25-hydroxycholesterol	65-71	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	144-150
29126212-4	2017	CYP7B1 deficiency has been shown to lead to accumulation of neurotoxic oxysterols.	Oxysterols	71-81	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
29689289-1	2018	Dihydroxycholesterols such as 7alpha,25-dihydroxysterols (7alpha,25-OHC) and 7alpha,27-OHC are generated from cholesterol by the enzymes CH25H, CYP7B1 and CYP27A1 in steady state but also in the context of inflammation.	7alpha	58-64	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	144-150
29689289-1	2018	Dihydroxycholesterols such as 7alpha,25-dihydroxysterols (7alpha,25-OHC) and 7alpha,27-OHC are generated from cholesterol by the enzymes CH25H, CYP7B1 and CYP27A1 in steady state but also in the context of inflammation.	27-hydroxycholesterol	84-90	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	144-150
29931794-4	2018	We made three unusual steroids by stable expression, in HEK293 cells, of the 7alpha-hydroxylase CYP7B1, which was selected because of its high native product yield.	Steroids	22-30	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	96-102
29931794-7	2018	A Rosetta docking model of CYP7B1 suggested that these substrates" D-ring hydroxy groups might prevent them from binding in the same way as the native substrates, bringing different carbon atoms close to the active ferryl oxygen atom.	Carbon	182-188	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	27-33
29931794-7	2018	A Rosetta docking model of CYP7B1 suggested that these substrates" D-ring hydroxy groups might prevent them from binding in the same way as the native substrates, bringing different carbon atoms close to the active ferryl oxygen atom.	Oxygen	222-228	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	27-33
29228183-3	2018	Spastic paraplegia type 5 (SPG5) is an autosomal recessive spastic paraplegia due to mutations in CYP7B1, which encodes a cytochrome P450 7alpha-hydroxylase implicated in cholesterol and bile acids metabolism.	Cholesterol	171-182	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	98-104
29228183-3	2018	Spastic paraplegia type 5 (SPG5) is an autosomal recessive spastic paraplegia due to mutations in CYP7B1, which encodes a cytochrome P450 7alpha-hydroxylase implicated in cholesterol and bile acids metabolism.	Bile Acids and Salts	187-197	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	98-104
29126212-10	2017	Biochemically, marked accumulation of CYP7B1 substrates including 27-hydroxycholesterol was confirmed in serum (n = 19) and cerebrospinal fluid (n = 17) of SPG5 patients.	27-hydroxycholesterol	66-87	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	38-44
28147280-3	2017	CH25H and CYP7B1 hydroxylate cholesterol to 7alpha,25-OHC.	Cholesterol	29-40	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	10-16
28147280-3	2017	CH25H and CYP7B1 hydroxylate cholesterol to 7alpha,25-OHC.	7alpha	44-50	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	10-16
28147280-3	2017	CH25H and CYP7B1 hydroxylate cholesterol to 7alpha,25-OHC.	25-hydroxycholesterol	51-57	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	10-16
24658845-0	2014	Liver disease in infancy caused by oxysterol 7 alpha-hydroxylase deficiency: successful treatment with chenodeoxycholic acid.	Chenodeoxycholic Acid	103-124	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	35-64
26901218-8	2016	Thus, genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin A (AKR1C3), and cholesterol (CYP39A1).	Vitamin D	40-49	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	117-123
26898310-4	2016	We also discuss expression and signalling of oxysterol-producing enzymes such as CH25H and CYP7B1 in the CNS and the immune system.	Oxysterols	45-54	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	91-97
26370385-10	2016	Reduced cytochrome P450-7B1 enzymatic activity could alter the balance among neurotoxic and neuroprotective oxysterols promoting motor neuron degeneration and/or immune response.	Oxysterols	108-118	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	8-27
26901218-8	2016	Thus, genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin A (AKR1C3), and cholesterol (CYP39A1).	Cholesterol	104-115	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	117-123
26901218-8	2016	Thus, genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin A (AKR1C3), and cholesterol (CYP39A1).	Vitamin A	230-239	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	117-123
26901218-8	2016	Thus, genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin A (AKR1C3), and cholesterol (CYP39A1).	Cholesterol	254-265	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	117-123
26299212-4	2015	Among these determinants are the oxysterol binding proteins expressed in macrophages, the level of expression of CYP7B1, the oxysterol 7 alpha hydroxylase that generates an inactive triol, and further oxidation of 27-hydroxycholestrol to the C27 acid by multifunctional CYP27A1.	Calcitriol	182-187	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	113-119
26299212-4	2015	Among these determinants are the oxysterol binding proteins expressed in macrophages, the level of expression of CYP7B1, the oxysterol 7 alpha hydroxylase that generates an inactive triol, and further oxidation of 27-hydroxycholestrol to the C27 acid by multifunctional CYP27A1.	Calcitriol	182-187	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	125-154
26299212-4	2015	Among these determinants are the oxysterol binding proteins expressed in macrophages, the level of expression of CYP7B1, the oxysterol 7 alpha hydroxylase that generates an inactive triol, and further oxidation of 27-hydroxycholestrol to the C27 acid by multifunctional CYP27A1.	c27 acid	242-250	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	113-119
25271621-5	2014	Mutations in CYP7B1 or CYP27A1, which encode enzymes involved in cholestenoic acid metabolism, result in different neurological diseases, hereditary spastic paresis type 5 (SPG5) and cerebrotendinous xanthomatosis (CTX), respectively.	cholestenoic acid	65-82	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	13-19
24927729-4	2014	The structure-based mutation T104L in the B" helix, corresponding to the nonpolar residue of CYP7B1, was used to obtain crystals of complexes with cholest-4-en-3-one and with cholesterol oxidation product 7-ketocholesterol (7KCh).	cholest-4-en-3-one	147-165	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	93-99
24927729-4	2014	The structure-based mutation T104L in the B" helix, corresponding to the nonpolar residue of CYP7B1, was used to obtain crystals of complexes with cholest-4-en-3-one and with cholesterol oxidation product 7-ketocholesterol (7KCh).	Cholesterol	175-186	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	93-99
24927729-4	2014	The structure-based mutation T104L in the B" helix, corresponding to the nonpolar residue of CYP7B1, was used to obtain crystals of complexes with cholest-4-en-3-one and with cholesterol oxidation product 7-ketocholesterol (7KCh).	7-ketocholesterol	205-222	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	93-99
24117163-1	2014	UNLABELLED: The SPG5A subtype of Hereditary Spastic Paraplegia (HSP) is a rare autosomal recessive neurodegenerative disorder caused by mutations in the CYP7B1 gene, which encodes a steroid cytochrome P450 7alpha-hydroxylase.	Steroids	182-189	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	16-21
24117163-1	2014	UNLABELLED: The SPG5A subtype of Hereditary Spastic Paraplegia (HSP) is a rare autosomal recessive neurodegenerative disorder caused by mutations in the CYP7B1 gene, which encodes a steroid cytochrome P450 7alpha-hydroxylase.	Steroids	182-189	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	153-159
24117163-12	2014	MRS showing elevated mI/Cr ratio in the white matter may be indicative of SPG5A.	Chromium	24-26	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	74-79
23869782-5	2014	Cutaneous 7-hydroxylases (CYP7A1, CYP7B1 and CYP39) potentially can produce 7-hydroxy/oxy-steroids/sterols with modifying effects on local tumorigenesis.	7-hydroxy/oxy-steroids	76-98	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	34-40
24491228-0	2014	Human steroid and oxysterol 7alpha-hydroxylase CYP7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants.	Azoles	78-83	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	18-46
24491228-0	2014	Human steroid and oxysterol 7alpha-hydroxylase CYP7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants.	Azoles	78-83	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	47-53
24491228-2	2014	CYP7B1 catalyzes the 6- or 7-hydroxylation of both steroids and oxysterols and thus is involved in the metabolism of neurosteroids and bile acid synthesis, respectively.	Steroids	51-59	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
24491228-2	2014	CYP7B1 catalyzes the 6- or 7-hydroxylation of both steroids and oxysterols and thus is involved in the metabolism of neurosteroids and bile acid synthesis, respectively.	Oxysterols	64-74	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
24491228-2	2014	CYP7B1 catalyzes the 6- or 7-hydroxylation of both steroids and oxysterols and thus is involved in the metabolism of neurosteroids and bile acid synthesis, respectively.	Bile Acids and Salts	135-144	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
24491228-4	2014	Here we present biochemical characterization of CYP7B1 at the molecular level to understand substrate specificity and susceptibility to azole drugs.	Azoles	136-141	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	48-54
24480442-7	2014	Supernatants of LPS-stimulated macrophages are able to stimulate EBI2 signaling indicating that an induction of CH25H, CYP27A1, and CYP7B1 results in an enhanced production and release of oxysterols into the cellular environment.	Oxysterols	188-198	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	132-138
24491228-5	2014	Based on our experiments with purified enzyme, the requirements for CYP7B1 hydroxylation of steroid molecules are as follows: C5 hydrogen in the alpha-configuration (or double bond at C5), a polar group at C17, a hydroxyl group at C3, and the absence of the hydroxyl group at C20-C24 in the C27-sterol side chain.	Steroids	92-99	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	68-74
24491228-5	2014	Based on our experiments with purified enzyme, the requirements for CYP7B1 hydroxylation of steroid molecules are as follows: C5 hydrogen in the alpha-configuration (or double bond at C5), a polar group at C17, a hydroxyl group at C3, and the absence of the hydroxyl group at C20-C24 in the C27-sterol side chain.	Hydrogen	129-137	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	68-74
24491228-6	2014	21-hydroxy-pregnenolone was identified as a new substrate, and overall low activity toward pregnanes could be related to the increased potency of 7-hydroxy derivatives produced by CYP7B1.	21-hydroxypregnenolone	0-23	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	180-186
24491228-6	2014	21-hydroxy-pregnenolone was identified as a new substrate, and overall low activity toward pregnanes could be related to the increased potency of 7-hydroxy derivatives produced by CYP7B1.	Pregnanes	91-100	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	180-186
24491228-7	2014	Metabolic conversion (deactivation) of oxysterols by CYP7B1 in a reconstituted system proceeds via two sequential hydroxylations.	Oxysterols	39-49	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	53-59
23869782-5	2014	Cutaneous 7-hydroxylases (CYP7A1, CYP7B1 and CYP39) potentially can produce 7-hydroxy/oxy-steroids/sterols with modifying effects on local tumorigenesis.	Sterols	99-106	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	34-40
22484622-0	2012	Effects of CYP7B1-related steroids on androgen receptor activation in different cell lines.	Steroids	26-34	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	11-17
22999953-2	2012	7alpha,25-OHC is synthesized from cholesterol by the stepwise actions of two enzymes, CH25H and CYP7B1, and is metabolized to a 3-oxo derivative by HSD3B7.	7alpha	0-6	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	96-102
22999953-2	2012	7alpha,25-OHC is synthesized from cholesterol by the stepwise actions of two enzymes, CH25H and CYP7B1, and is metabolized to a 3-oxo derivative by HSD3B7.	25-hydroxycholesterol	7-13	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	96-102
22999953-2	2012	7alpha,25-OHC is synthesized from cholesterol by the stepwise actions of two enzymes, CH25H and CYP7B1, and is metabolized to a 3-oxo derivative by HSD3B7.	Cholesterol	34-45	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	96-102
22999953-7	2012	These findings establish that CYP7B1 and HSD3B7, as well as CH25H, have essential roles in controlling oxysterol production in lymphoid tissues, and they suggest that differential enzyme expression in stromal cell subsets establishes 7alpha,25-OHC gradients required for B cell responses.	Oxysterols	103-112	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	30-36
25374487-3	2014	Microarray showed that the gene encoding cytochrome P450 7B1 (CYP7B1), an isozyme for bile acid synthesis, was highly expressed in the PAH lung compared with the control.	Bile Acids and Salts	86-95	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	41-60
25374487-3	2014	Microarray showed that the gene encoding cytochrome P450 7B1 (CYP7B1), an isozyme for bile acid synthesis, was highly expressed in the PAH lung compared with the control.	Bile Acids and Salts	86-95	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	62-68
25374487-4	2014	CYP7B1 protein was found to be primarily localized on pulmonary vascular endothelial cells suggesting de novo bile acid synthesis may be involved in the development of PAH.	Bile Acids and Salts	110-119	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
23391614-11	2013	These findings reveal a potential shift toward the alternative pathway of BA synthesis during NASH, mediated by increased mRNA and protein expression of CYP7B1.	Bile Acids and Salts	74-76	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	153-159
23180418-1	2013	Cytochrome P450 (CYP) 7B1 is a steroid cytochrome P450 7alpha-hydroxylase that has been linked directly with bile salt synthesis and hereditary spastic paraplegia type 5 (SPG5).	Bile Acids and Salts	109-118	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-25
22484622-1	2012	The widely expressed steroid hydroxylase CYP7B1 is involved in metabolism of a number of steroids reported to influence estrogen and androgen signaling.	Steroids	89-97	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	41-47
22484622-5	2012	The results indicate significantly lower androgen receptor activation by CYP7B1-formed steroid metabolites than by the corresponding steroid substrates, suggesting that CYP7B1-mediated catalysis may decrease some androgenic responses.	Steroids	87-94	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	73-79
22484622-5	2012	The results indicate significantly lower androgen receptor activation by CYP7B1-formed steroid metabolites than by the corresponding steroid substrates, suggesting that CYP7B1-mediated catalysis may decrease some androgenic responses.	Steroids	87-94	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	169-175
22484622-5	2012	The results indicate significantly lower androgen receptor activation by CYP7B1-formed steroid metabolites than by the corresponding steroid substrates, suggesting that CYP7B1-mediated catalysis may decrease some androgenic responses.	Steroids	133-140	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	169-175
22542504-6	2012	The metabolism of DHT to 3beta-diol is a viable pathway in HBVSMC since mRNA for enzymes necessary for the synthesis and metabolism of 3beta-diol [3alpha-hydroxysteroid dehydrogenase (HSD), 3beta-HSD, 17beta-HSD, CYP7B1] was detected.	Dihydrotestosterone	18-21	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	213-219
22542504-6	2012	The metabolism of DHT to 3beta-diol is a viable pathway in HBVSMC since mRNA for enzymes necessary for the synthesis and metabolism of 3beta-diol [3alpha-hydroxysteroid dehydrogenase (HSD), 3beta-HSD, 17beta-HSD, CYP7B1] was detected.	Androstane-3,17-diol	25-35	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	213-219
22111624-8	2012	In line with this, Cyp7b1 knockouts are also apparently normal, whereas human CYP7B1 mutations lead to a congenital bile acid synthesis defect in children or spastic paraplegia in adults.	Bile Acids and Salts	116-125	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	78-84
21541746-4	2012	Evaluation of the active site residues of the CYP7B1 model and validation of the active site architecture were performed via molecular docking experiments: the docking of the substrates 25-hydroxycholesterol and 27-hydroxycholesterol and the inhibitor 3alpha-Adiol identified structurally and functionally important residues.	25-hydroxycholesterol	186-207	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	46-52
25436707-1	2012	Abstract Successive action of cytochrome P450-7B1 (CYP7B1) and 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) on 3beta-hydroxysteroids such as DHEA and epiandrosterone leads to the production of cytoprotective 7beta-hydroxylated derivatives.	3beta-hydroxysteroids	123-144	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	30-49
25436707-1	2012	Abstract Successive action of cytochrome P450-7B1 (CYP7B1) and 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) on 3beta-hydroxysteroids such as DHEA and epiandrosterone leads to the production of cytoprotective 7beta-hydroxylated derivatives.	3beta-hydroxysteroids	123-144	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	51-57
25436707-1	2012	Abstract Successive action of cytochrome P450-7B1 (CYP7B1) and 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) on 3beta-hydroxysteroids such as DHEA and epiandrosterone leads to the production of cytoprotective 7beta-hydroxylated derivatives.	Dehydroepiandrosterone	153-157	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	30-49
25436707-1	2012	Abstract Successive action of cytochrome P450-7B1 (CYP7B1) and 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) on 3beta-hydroxysteroids such as DHEA and epiandrosterone leads to the production of cytoprotective 7beta-hydroxylated derivatives.	Dehydroepiandrosterone	153-157	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	51-57
25436707-1	2012	Abstract Successive action of cytochrome P450-7B1 (CYP7B1) and 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) on 3beta-hydroxysteroids such as DHEA and epiandrosterone leads to the production of cytoprotective 7beta-hydroxylated derivatives.	Androsterone	162-177	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	30-49
25436707-1	2012	Abstract Successive action of cytochrome P450-7B1 (CYP7B1) and 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) on 3beta-hydroxysteroids such as DHEA and epiandrosterone leads to the production of cytoprotective 7beta-hydroxylated derivatives.	Androsterone	162-177	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	51-57
25436707-1	2012	Abstract Successive action of cytochrome P450-7B1 (CYP7B1) and 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) on 3beta-hydroxysteroids such as DHEA and epiandrosterone leads to the production of cytoprotective 7beta-hydroxylated derivatives.	7beta	220-225	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	30-49
25436707-1	2012	Abstract Successive action of cytochrome P450-7B1 (CYP7B1) and 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) on 3beta-hydroxysteroids such as DHEA and epiandrosterone leads to the production of cytoprotective 7beta-hydroxylated derivatives.	7beta	220-225	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	51-57
25436707-4	2012	As low doses of the 7beta-hydroxylated derivatives of DHEA and epiandrosterone trigger the resolution of inflammation and tissue repair, CYP7B1 and 11beta-HSD1 tissue contents may reflect the tissue ability for reparation after pathological conditions.	Dehydroepiandrosterone	54-58	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	137-143
21214876-1	2012	Spastic paraplegia type 5 (SPG5) is caused by mutations in CYP7B1, a gene encoding the cytochrome P-450 oxysterol 7-alpha-hydroxylase, CYP7B1, an enzyme implicated in the cholesterol metabolism.	Cholesterol	171-182	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	59-65
21214876-1	2012	Spastic paraplegia type 5 (SPG5) is caused by mutations in CYP7B1, a gene encoding the cytochrome P-450 oxysterol 7-alpha-hydroxylase, CYP7B1, an enzyme implicated in the cholesterol metabolism.	Cholesterol	171-182	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	135-141
21541746-4	2012	Evaluation of the active site residues of the CYP7B1 model and validation of the active site architecture were performed via molecular docking experiments: the docking of the substrates 25-hydroxycholesterol and 27-hydroxycholesterol and the inhibitor 3alpha-Adiol identified structurally and functionally important residues.	27-hydroxycholesterol	212-233	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	46-52
21541746-4	2012	Evaluation of the active site residues of the CYP7B1 model and validation of the active site architecture were performed via molecular docking experiments: the docking of the substrates 25-hydroxycholesterol and 27-hydroxycholesterol and the inhibitor 3alpha-Adiol identified structurally and functionally important residues.	3alpha-adiol	252-264	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	46-52
21966169-0	2011	Ethnic differences in the prevalence of polymorphisms in CYP7A1, CYP7B1 AND CYP27A1 enzymes involved in cholesterol metabolism.	Cholesterol	104-115	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	65-71
25961225-8	2010	Other DHEA and testosterone-derived metabolites, namely epiandrosterone and 5alpha-androstane-3beta,17beta-diol, are also substrates for the CYP7B1 and their 7alpha-hydroxylated products were also converted into the 7beta epimer by the 11beta-HSD1.	Testosterone	15-27	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	141-147
22235657-10	2011	Some of those factors influence the activities of other bile acids biosynthesis enzymes--CYP7B1, CYP27A1, CYP8B1.	Bile Acids and Salts	56-66	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	89-95
25961225-6	2010	In addition, DHEA is hydroxylated at the 7alpha position by the cytochrome P450 7B1 (CYP7B1), and the 7alpha-hydroxy-DHEA produced is a substrate for the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) which converts it into 7beta-hydroxy-DHEA.	Dehydroepiandrosterone	13-17	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	64-83
25961225-6	2010	In addition, DHEA is hydroxylated at the 7alpha position by the cytochrome P450 7B1 (CYP7B1), and the 7alpha-hydroxy-DHEA produced is a substrate for the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) which converts it into 7beta-hydroxy-DHEA.	Dehydroepiandrosterone	13-17	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	85-91
25961225-8	2010	Other DHEA and testosterone-derived metabolites, namely epiandrosterone and 5alpha-androstane-3beta,17beta-diol, are also substrates for the CYP7B1 and their 7alpha-hydroxylated products were also converted into the 7beta epimer by the 11beta-HSD1.	Androsterone	56-71	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	141-147
25961225-8	2010	Other DHEA and testosterone-derived metabolites, namely epiandrosterone and 5alpha-androstane-3beta,17beta-diol, are also substrates for the CYP7B1 and their 7alpha-hydroxylated products were also converted into the 7beta epimer by the 11beta-HSD1.	5alpha-androstane-3beta	76-99	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	141-147
25961225-6	2010	In addition, DHEA is hydroxylated at the 7alpha position by the cytochrome P450 7B1 (CYP7B1), and the 7alpha-hydroxy-DHEA produced is a substrate for the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) which converts it into 7beta-hydroxy-DHEA.	7-hydroxydehydroepiandrosterone	102-121	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	64-83
25961225-6	2010	In addition, DHEA is hydroxylated at the 7alpha position by the cytochrome P450 7B1 (CYP7B1), and the 7alpha-hydroxy-DHEA produced is a substrate for the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) which converts it into 7beta-hydroxy-DHEA.	7-hydroxydehydroepiandrosterone	102-121	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	85-91
25961225-6	2010	In addition, DHEA is hydroxylated at the 7alpha position by the cytochrome P450 7B1 (CYP7B1), and the 7alpha-hydroxy-DHEA produced is a substrate for the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) which converts it into 7beta-hydroxy-DHEA.	7-hydroxydehydroepiandrosterone	234-252	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	64-83
25961225-6	2010	In addition, DHEA is hydroxylated at the 7alpha position by the cytochrome P450 7B1 (CYP7B1), and the 7alpha-hydroxy-DHEA produced is a substrate for the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) which converts it into 7beta-hydroxy-DHEA.	7-hydroxydehydroepiandrosterone	234-252	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	85-91
25961225-8	2010	Other DHEA and testosterone-derived metabolites, namely epiandrosterone and 5alpha-androstane-3beta,17beta-diol, are also substrates for the CYP7B1 and their 7alpha-hydroxylated products were also converted into the 7beta epimer by the 11beta-HSD1.	Dehydroepiandrosterone	6-10	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	141-147
25961225-8	2010	Other DHEA and testosterone-derived metabolites, namely epiandrosterone and 5alpha-androstane-3beta,17beta-diol, are also substrates for the CYP7B1 and their 7alpha-hydroxylated products were also converted into the 7beta epimer by the 11beta-HSD1.	17beta-diol	100-111	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	141-147
25961225-13	2010	Treatments with DHEA should take into account the target tissue abilities to produce the desired metabolites through the two key enzymes, CYP7B1 and 11beta-HSD1.	Dehydroepiandrosterone	16-20	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	138-144
18331353-0	2008	CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling.	Dehydroepiandrosterone	30-52	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
20699090-14	2010	Synthesis of BAs from cholesterol occurs either via the classical pathway (7alpha-hydroxylation of cholesterol; CYP7A1) or via the alternate pathway (CYP39A1 or CYP7B1).	Barium	13-16	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	161-167
20699090-14	2010	Synthesis of BAs from cholesterol occurs either via the classical pathway (7alpha-hydroxylation of cholesterol; CYP7A1) or via the alternate pathway (CYP39A1 or CYP7B1).	Cholesterol	22-33	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	161-167
19732851-0	2009	CYP7B1-mediated metabolism of 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol): a novel pathway for potential regulation of the cellular levels of androgens and neurosteroids.	5alpha-androstane-3alpha	30-54	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
19732851-0	2009	CYP7B1-mediated metabolism of 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol): a novel pathway for potential regulation of the cellular levels of androgens and neurosteroids.	17beta-diol	55-66	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
19732851-0	2009	CYP7B1-mediated metabolism of 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol): a novel pathway for potential regulation of the cellular levels of androgens and neurosteroids.	Androstane-3,17-diol	68-80	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
19732851-1	2009	The current study presents data indicating that 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol) undergoes a previously unknown metabolism into hydroxymetabolites, catalyzed by CYP7B1.	5alpha-androstane-3alpha	48-72	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	180-186
19732851-1	2009	The current study presents data indicating that 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol) undergoes a previously unknown metabolism into hydroxymetabolites, catalyzed by CYP7B1.	17beta-diol	73-84	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	180-186
19732851-1	2009	The current study presents data indicating that 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol) undergoes a previously unknown metabolism into hydroxymetabolites, catalyzed by CYP7B1.	Androstane-3,17-diol	86-98	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	180-186
19732851-3	2009	The steroid hydroxylase CYP7B1 is known to metabolize cholesterol derivatives, sex hormone precursors and certain estrogens, but has previously not been thought to act on androgens or 3alpha-hydroxylated steroids.	Cholesterol	54-65	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	24-30
19732851-3	2009	The steroid hydroxylase CYP7B1 is known to metabolize cholesterol derivatives, sex hormone precursors and certain estrogens, but has previously not been thought to act on androgens or 3alpha-hydroxylated steroids.	Steroids	204-212	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	24-30
19732851-4	2009	3alpha-Adiol was found to undergo NADPH-dependent metabolism into 6- and 7-hydroxymetabolites in incubations with porcine microsomes and human kidney-derived HEK293 cells, which are high in CYP7B1 content.	Androstane-3,17-diol	0-12	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	190-196
19732851-4	2009	3alpha-Adiol was found to undergo NADPH-dependent metabolism into 6- and 7-hydroxymetabolites in incubations with porcine microsomes and human kidney-derived HEK293 cells, which are high in CYP7B1 content.	NADP	34-39	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	190-196
19732851-4	2009	3alpha-Adiol was found to undergo NADPH-dependent metabolism into 6- and 7-hydroxymetabolites in incubations with porcine microsomes and human kidney-derived HEK293 cells, which are high in CYP7B1 content.	6- and 7-hydroxymetabolites	66-93	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	190-196
19732851-5	2009	This metabolism was suppressed by addition of steroids known to be metabolized by CYP7B1.	Steroids	46-54	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	82-88
19732851-6	2009	In addition, 3alpha-Adiol significantly suppressed CYP7B1-mediated catalytic reactions, in a way as would be expected for substrates that compete for the same enzyme.	Androstane-3,17-diol	13-25	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	51-57
19732851-7	2009	Recombinant expression of human CYP7B1 in HEK293 cells significantly increased the rate of 3alpha-Adiol hydroxylation.	Androstane-3,17-diol	91-103	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	32-38
19687010-1	2009	The CYP7B1 cytochrome P450 enzyme hydroxylates carbons 6 and 7 of the B ring of oxysterols and steroids.	Carbon	47-54	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	4-10
19687010-1	2009	The CYP7B1 cytochrome P450 enzyme hydroxylates carbons 6 and 7 of the B ring of oxysterols and steroids.	Oxysterols	80-90	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	4-10
19687010-1	2009	The CYP7B1 cytochrome P450 enzyme hydroxylates carbons 6 and 7 of the B ring of oxysterols and steroids.	Steroids	95-103	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	4-10
19687010-4	2009	Hepatic CYP7B1 activity is crucial for the inactivation of oxysterols and their subsequent conversion into bile salts.	Oxysterols	59-69	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	8-14
19687010-4	2009	Hepatic CYP7B1 activity is crucial for the inactivation of oxysterols and their subsequent conversion into bile salts.	Bile Acids and Salts	107-117	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	8-14
18790053-1	2008	The steroid hydroxylase CYP7B1 metabolizes neurosteroids, cholesterol derivatives, and estrogen receptor (ER) ligands.	Cholesterol	58-69	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	24-30
18790053-4	2008	Treatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), abolished ER-mediated up-regulation of a CYP7B1 promoter-luciferase reporter in HepG2 cells, whereas overexpression of PI3K or Akt significantly increased estrogenic up-regulation of CYP7B1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	128-134
18790053-4	2008	Treatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), abolished ER-mediated up-regulation of a CYP7B1 promoter-luciferase reporter in HepG2 cells, whereas overexpression of PI3K or Akt significantly increased estrogenic up-regulation of CYP7B1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	270-276
20302934-10	2010	The likely involvement of oxysterol 7alpha-hydroxylase (CYP7B1) from the "acidic" pathway of bile acid synthesis and 11beta-hydroxysteroid dehydrogenase-1 in the generation of the 7-oxo group is discussed.	Bile Acids and Salts	93-102	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	26-54
20302934-10	2010	The likely involvement of oxysterol 7alpha-hydroxylase (CYP7B1) from the "acidic" pathway of bile acid synthesis and 11beta-hydroxysteroid dehydrogenase-1 in the generation of the 7-oxo group is discussed.	Bile Acids and Salts	93-102	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	56-62
18331353-0	2008	CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling.	5alpha-androstane-3beta	57-80	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
18331353-0	2008	CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling.	17beta-diol	81-92	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
18331353-1	2008	CYP7B1, a cytochrome P450 enzyme, metabolizes several steroids involved in hormonal signaling including 5alpha-androstane-3beta,17beta-diol (3beta-Adiol), an estrogen receptor agonist, and dehydroepiandrosterone, a precursor for sex hormones.	Steroids	54-62	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
18331353-1	2008	CYP7B1, a cytochrome P450 enzyme, metabolizes several steroids involved in hormonal signaling including 5alpha-androstane-3beta,17beta-diol (3beta-Adiol), an estrogen receptor agonist, and dehydroepiandrosterone, a precursor for sex hormones.	5alpha-androstane-3beta	104-127	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
18331353-1	2008	CYP7B1, a cytochrome P450 enzyme, metabolizes several steroids involved in hormonal signaling including 5alpha-androstane-3beta,17beta-diol (3beta-Adiol), an estrogen receptor agonist, and dehydroepiandrosterone, a precursor for sex hormones.	17beta-diol	128-139	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
18331353-1	2008	CYP7B1, a cytochrome P450 enzyme, metabolizes several steroids involved in hormonal signaling including 5alpha-androstane-3beta,17beta-diol (3beta-Adiol), an estrogen receptor agonist, and dehydroepiandrosterone, a precursor for sex hormones.	Androstane-3,17-diol	141-152	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
18331353-1	2008	CYP7B1, a cytochrome P450 enzyme, metabolizes several steroids involved in hormonal signaling including 5alpha-androstane-3beta,17beta-diol (3beta-Adiol), an estrogen receptor agonist, and dehydroepiandrosterone, a precursor for sex hormones.	Dehydroepiandrosterone	189-211	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
18331353-2	2008	Previous studies have suggested that CYP7B1-dependent metabolism involving dehydroepiandrosterone or 3beta-Adiol may play an important role for estrogen receptor beta-mediated signaling.	Dehydroepiandrosterone	75-97	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	37-43
18331353-2	2008	Previous studies have suggested that CYP7B1-dependent metabolism involving dehydroepiandrosterone or 3beta-Adiol may play an important role for estrogen receptor beta-mediated signaling.	Androstane-3,17-diol	101-112	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	37-43
18331353-3	2008	However, conflicting data are reported regarding the influence of different CYP7B1-related steroids on estrogen receptor beta activation.	Steroids	91-99	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	76-82
18331353-4	2008	In the present study, we investigated CYP7B1-mediated conversions of dehydroepiandrosterone and 3beta-Adiol in porcine microsomes and human kidney cells.	Dehydroepiandrosterone	69-91	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	38-44
18331353-4	2008	In the present study, we investigated CYP7B1-mediated conversions of dehydroepiandrosterone and 3beta-Adiol in porcine microsomes and human kidney cells.	Androstane-3,17-diol	96-107	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	38-44
18331353-5	2008	As part of these studies, we compared the effects of 3beta-Adiol (a CYP7B1 substrate) and 7alpha-hydroxy-dehydroepiandrosterone (a CYP7B1 product) on estrogen receptor beta activation.	7-hydroxydehydroepiandrosterone	90-127	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	131-137
18331353-6	2008	The data obtained indicated that 3beta-Adiol is a more efficient activator, thus lending support to the notion that CYP7B1 catalysis may decrease estrogen receptor beta activation.	Androstane-3,17-diol	33-44	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	116-122
18331353-7	2008	Our data on metabolism indicate that the efficiencies of CYP7B1-mediated hydroxylations of dehydroepiandrosterone and 3beta-Adiol are very similar.	Dehydroepiandrosterone	91-113	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	57-63
18331353-7	2008	Our data on metabolism indicate that the efficiencies of CYP7B1-mediated hydroxylations of dehydroepiandrosterone and 3beta-Adiol are very similar.	Androstane-3,17-diol	118-129	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	57-63
18331353-9	2008	A high dehydroepiandrosterone/3beta-Adiol ratio in the incubation mixtures, similar to the ratio of these steroids in many human tissues, strongly suppressed CYP7B1-mediated 3beta-Adiol metabolism.	Dehydroepiandrosterone	7-29	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	158-164
18331353-9	2008	A high dehydroepiandrosterone/3beta-Adiol ratio in the incubation mixtures, similar to the ratio of these steroids in many human tissues, strongly suppressed CYP7B1-mediated 3beta-Adiol metabolism.	Androstane-3,17-diol	30-41	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	158-164
18331353-9	2008	A high dehydroepiandrosterone/3beta-Adiol ratio in the incubation mixtures, similar to the ratio of these steroids in many human tissues, strongly suppressed CYP7B1-mediated 3beta-Adiol metabolism.	Steroids	106-114	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	158-164
18331353-9	2008	A high dehydroepiandrosterone/3beta-Adiol ratio in the incubation mixtures, similar to the ratio of these steroids in many human tissues, strongly suppressed CYP7B1-mediated 3beta-Adiol metabolism.	Androstane-3,17-diol	174-185	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	158-164
18331353-10	2008	As the efficiencies of CYP7B1-mediated hydroxylation of dehydroepiandrosterone and 3beta-Adiol are similar, we propose that varying steroid concentrations may be the most important factor determining the rate of CYP7B1-mediated metabolism of dehydroepiandrosterone or 3beta-Adiol.	Dehydroepiandrosterone	56-78	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	23-29
18331353-10	2008	As the efficiencies of CYP7B1-mediated hydroxylation of dehydroepiandrosterone and 3beta-Adiol are similar, we propose that varying steroid concentrations may be the most important factor determining the rate of CYP7B1-mediated metabolism of dehydroepiandrosterone or 3beta-Adiol.	Dehydroepiandrosterone	56-78	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	212-218
18331353-10	2008	As the efficiencies of CYP7B1-mediated hydroxylation of dehydroepiandrosterone and 3beta-Adiol are similar, we propose that varying steroid concentrations may be the most important factor determining the rate of CYP7B1-mediated metabolism of dehydroepiandrosterone or 3beta-Adiol.	Androstane-3,17-diol	83-94	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	23-29
18331353-10	2008	As the efficiencies of CYP7B1-mediated hydroxylation of dehydroepiandrosterone and 3beta-Adiol are similar, we propose that varying steroid concentrations may be the most important factor determining the rate of CYP7B1-mediated metabolism of dehydroepiandrosterone or 3beta-Adiol.	Androstane-3,17-diol	83-94	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	212-218
18331353-10	2008	As the efficiencies of CYP7B1-mediated hydroxylation of dehydroepiandrosterone and 3beta-Adiol are similar, we propose that varying steroid concentrations may be the most important factor determining the rate of CYP7B1-mediated metabolism of dehydroepiandrosterone or 3beta-Adiol.	Steroids	132-139	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	23-29
18331353-10	2008	As the efficiencies of CYP7B1-mediated hydroxylation of dehydroepiandrosterone and 3beta-Adiol are similar, we propose that varying steroid concentrations may be the most important factor determining the rate of CYP7B1-mediated metabolism of dehydroepiandrosterone or 3beta-Adiol.	Steroids	132-139	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	212-218
18331353-10	2008	As the efficiencies of CYP7B1-mediated hydroxylation of dehydroepiandrosterone and 3beta-Adiol are similar, we propose that varying steroid concentrations may be the most important factor determining the rate of CYP7B1-mediated metabolism of dehydroepiandrosterone or 3beta-Adiol.	Dehydroepiandrosterone	242-264	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	23-29
18331353-10	2008	As the efficiencies of CYP7B1-mediated hydroxylation of dehydroepiandrosterone and 3beta-Adiol are similar, we propose that varying steroid concentrations may be the most important factor determining the rate of CYP7B1-mediated metabolism of dehydroepiandrosterone or 3beta-Adiol.	Dehydroepiandrosterone	242-264	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	212-218
18331353-10	2008	As the efficiencies of CYP7B1-mediated hydroxylation of dehydroepiandrosterone and 3beta-Adiol are similar, we propose that varying steroid concentrations may be the most important factor determining the rate of CYP7B1-mediated metabolism of dehydroepiandrosterone or 3beta-Adiol.	Androstane-3,17-diol	268-279	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	23-29
18331353-10	2008	As the efficiencies of CYP7B1-mediated hydroxylation of dehydroepiandrosterone and 3beta-Adiol are similar, we propose that varying steroid concentrations may be the most important factor determining the rate of CYP7B1-mediated metabolism of dehydroepiandrosterone or 3beta-Adiol.	Androstane-3,17-diol	268-279	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	212-218
18331353-11	2008	Consequently, tissue-specific steroid concentrations may have a strong impact on CYP7B1-dependent catalysis and thus on the levels of different CYP7B1-related steroids that can influence estrogen receptor beta signaling.	Steroids	30-37	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	81-87
18331353-11	2008	Consequently, tissue-specific steroid concentrations may have a strong impact on CYP7B1-dependent catalysis and thus on the levels of different CYP7B1-related steroids that can influence estrogen receptor beta signaling.	Steroids	30-37	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	144-150
18331353-11	2008	Consequently, tissue-specific steroid concentrations may have a strong impact on CYP7B1-dependent catalysis and thus on the levels of different CYP7B1-related steroids that can influence estrogen receptor beta signaling.	Steroids	159-167	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	144-150
18252231-0	2008	Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration.	Cholesterol	55-66	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	28-34
18252231-5	2008	In the liver, CYP7B1 offers an alternative pathway for cholesterol degradation and also provides the primary metabolic route for the modification of dehydroepiandrosterone neurosteroids in the brain.	Cholesterol	55-66	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	14-20
18252231-5	2008	In the liver, CYP7B1 offers an alternative pathway for cholesterol degradation and also provides the primary metabolic route for the modification of dehydroepiandrosterone neurosteroids in the brain.	dehydroepiandrosterone neurosteroids	149-185	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	14-20
17825335-4	2007	Among testosterone metabolites, 5alpha-androstane-3beta,17beta-diol (Adiol) is a substrate for the cytochrome P450 7B1 which produces 5alpha-androstane-3beta,7alpha,17beta-triol (7alpha-Adiol).	Testosterone	6-18	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	99-118
17825335-4	2007	Among testosterone metabolites, 5alpha-androstane-3beta,17beta-diol (Adiol) is a substrate for the cytochrome P450 7B1 which produces 5alpha-androstane-3beta,7alpha,17beta-triol (7alpha-Adiol).	5alpha-androstane-3beta	32-55	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	99-118
17825335-4	2007	Among testosterone metabolites, 5alpha-androstane-3beta,17beta-diol (Adiol) is a substrate for the cytochrome P450 7B1 which produces 5alpha-androstane-3beta,7alpha,17beta-triol (7alpha-Adiol).	17beta-diol	56-67	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	99-118
17825335-4	2007	Among testosterone metabolites, 5alpha-androstane-3beta,17beta-diol (Adiol) is a substrate for the cytochrome P450 7B1 which produces 5alpha-androstane-3beta,7alpha,17beta-triol (7alpha-Adiol).	Androstane-3,17-diol	69-74	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	99-118
17825335-4	2007	Among testosterone metabolites, 5alpha-androstane-3beta,17beta-diol (Adiol) is a substrate for the cytochrome P450 7B1 which produces 5alpha-androstane-3beta,7alpha,17beta-triol (7alpha-Adiol).	5alpha-androstane-3beta	134-157	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	99-118
17825335-4	2007	Among testosterone metabolites, 5alpha-androstane-3beta,17beta-diol (Adiol) is a substrate for the cytochrome P450 7B1 which produces 5alpha-androstane-3beta,7alpha,17beta-triol (7alpha-Adiol).	7alpha	158-164	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	99-118
17825335-4	2007	Among testosterone metabolites, 5alpha-androstane-3beta,17beta-diol (Adiol) is a substrate for the cytochrome P450 7B1 which produces 5alpha-androstane-3beta,7alpha,17beta-triol (7alpha-Adiol).	17beta-triol	165-177	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	99-118
17825335-4	2007	Among testosterone metabolites, 5alpha-androstane-3beta,17beta-diol (Adiol) is a substrate for the cytochrome P450 7B1 which produces 5alpha-androstane-3beta,7alpha,17beta-triol (7alpha-Adiol).	7alpha-adiol	179-191	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	99-118
17639508-2	2007	Cytochrome P450 (CYP) 7B1 is expressed within the prostate and may determine the levels of the natural estrogen receptor beta (ERbeta) ligand 5alpha-androstane-3beta,17beta-diol (3betaAdiol) available and hence affect the regulation of prostate proliferation.	5alpha-androstane-3beta	142-165	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-25
17639508-2	2007	Cytochrome P450 (CYP) 7B1 is expressed within the prostate and may determine the levels of the natural estrogen receptor beta (ERbeta) ligand 5alpha-androstane-3beta,17beta-diol (3betaAdiol) available and hence affect the regulation of prostate proliferation.	17beta-diol	166-177	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-25
17639508-2	2007	Cytochrome P450 (CYP) 7B1 is expressed within the prostate and may determine the levels of the natural estrogen receptor beta (ERbeta) ligand 5alpha-androstane-3beta,17beta-diol (3betaAdiol) available and hence affect the regulation of prostate proliferation.	Androstane-3,17-diol	179-189	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-25
16630558-4	2006	The current study showed strong suppression of a human CYP7B1 luciferase reporter gene by dihydrotestosterone (DHT) in prostate cancer LNCaP cells.	Dihydrotestosterone	90-109	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	55-61
17467270-1	2007	Dehydroepiandrosterone (DHEA) is 7alpha-hydroxylated by the cytochome P450 7B1 (CYP7B1) in the human brain and liver.	Dehydroepiandrosterone	0-22	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	60-78
17467270-1	2007	Dehydroepiandrosterone (DHEA) is 7alpha-hydroxylated by the cytochome P450 7B1 (CYP7B1) in the human brain and liver.	Dehydroepiandrosterone	0-22	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	80-86
17467270-1	2007	Dehydroepiandrosterone (DHEA) is 7alpha-hydroxylated by the cytochome P450 7B1 (CYP7B1) in the human brain and liver.	Dehydroepiandrosterone	24-28	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	60-78
17467270-1	2007	Dehydroepiandrosterone (DHEA) is 7alpha-hydroxylated by the cytochome P450 7B1 (CYP7B1) in the human brain and liver.	Dehydroepiandrosterone	24-28	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	80-86
16713254-1	2006	Circulating 3beta-hydroxysteroids including dehydroepiandrosterone (DHEA) are 7alpha-hydroxylated by the cytochrome P450-7B1 in the liver, skin and brain, which are the target organs of glucocorticoids.	3beta-hydroxysteroids	12-33	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	105-124
16713254-1	2006	Circulating 3beta-hydroxysteroids including dehydroepiandrosterone (DHEA) are 7alpha-hydroxylated by the cytochrome P450-7B1 in the liver, skin and brain, which are the target organs of glucocorticoids.	Dehydroepiandrosterone	44-66	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	105-124
16713254-1	2006	Circulating 3beta-hydroxysteroids including dehydroepiandrosterone (DHEA) are 7alpha-hydroxylated by the cytochrome P450-7B1 in the liver, skin and brain, which are the target organs of glucocorticoids.	Dehydroepiandrosterone	68-72	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	105-124
16720094-0	2006	Estrogen-mediated regulation of CYP7B1: a possible role for controlling DHEA levels in human tissues.	Dehydroepiandrosterone	72-76	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	32-38
16720094-2	2006	Transfection with estrogen receptor alpha and treatment with 17beta-estradiol in human embryonic kidney 293 cells significantly increased CYP7B1 catalytic activity and mRNA, and stimulated a human CYP7B1 reporter gene.	Estradiol	61-77	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	138-144
16720094-2	2006	Transfection with estrogen receptor alpha and treatment with 17beta-estradiol in human embryonic kidney 293 cells significantly increased CYP7B1 catalytic activity and mRNA, and stimulated a human CYP7B1 reporter gene.	Estradiol	61-77	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	197-203
16720094-4	2006	In the absence of receptors, 17beta-estradiol suppressed CYP7B1 activity, suggesting that estrogenic effects may be different in cells not expressing receptors.	Estradiol	29-45	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	57-63
16720094-8	2006	Since CYP7B1 diverts DHEA from the sex hormone biosynthetic pathway, estrogen receptor-mediated up-regulation of CYP7B1 should lead to less DHEA available for sex hormone synthesis and may help to maintain normal levels of estrogens and androgens in human tissues, especially during fetal development.	Dehydroepiandrosterone	21-25	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	6-12
16720094-8	2006	Since CYP7B1 diverts DHEA from the sex hormone biosynthetic pathway, estrogen receptor-mediated up-regulation of CYP7B1 should lead to less DHEA available for sex hormone synthesis and may help to maintain normal levels of estrogens and androgens in human tissues, especially during fetal development.	Dehydroepiandrosterone	21-25	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	113-119
16720094-8	2006	Since CYP7B1 diverts DHEA from the sex hormone biosynthetic pathway, estrogen receptor-mediated up-regulation of CYP7B1 should lead to less DHEA available for sex hormone synthesis and may help to maintain normal levels of estrogens and androgens in human tissues, especially during fetal development.	Dehydroepiandrosterone	140-144	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	113-119
16720094-9	2006	Regulation by estrogens may also be of importance in other processes where CYP7B1 is involved, including cholesterol homeostasis, cellular proliferation, and CNS function.	Cholesterol	105-116	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	75-81
16630558-4	2006	The current study showed strong suppression of a human CYP7B1 luciferase reporter gene by dihydrotestosterone (DHT) in prostate cancer LNCaP cells.	Dihydrotestosterone	111-114	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	55-61
16630558-5	2006	Also, DHT and overexpression of androgen receptor (AR) suppressed CYP7B1 promoter activity and CYP7B1-mediated catalysis in kidney-derived HEK293 cells.	Dihydrotestosterone	6-9	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	66-72
16630558-5	2006	Also, DHT and overexpression of androgen receptor (AR) suppressed CYP7B1 promoter activity and CYP7B1-mediated catalysis in kidney-derived HEK293 cells.	Dihydrotestosterone	6-9	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	95-101
16630558-8	2006	CYP7B1 was stimulated by synthetic ER agonists but suppressed by 17beta-estradiol and 5alpha-androstane-3beta,17beta-diol in LNCaP cells.	Estradiol	65-81	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
16630558-8	2006	CYP7B1 was stimulated by synthetic ER agonists but suppressed by 17beta-estradiol and 5alpha-androstane-3beta,17beta-diol in LNCaP cells.	5alpha-androstane-3beta	86-109	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
16630558-8	2006	CYP7B1 was stimulated by synthetic ER agonists but suppressed by 17beta-estradiol and 5alpha-androstane-3beta,17beta-diol in LNCaP cells.	17beta-diol	110-121	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
16630558-9	2006	Our data indicate an important role for CYP7B1 in balancing prostate hormone levels in human cells.	prostate hormone	60-76	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	40-46
16603347-8	2006	The 7alpha-hydroxy-DHEA produced by the cytochrome CYP7B1 in tissues may exert anti-glucocorticoid effects through interference with the 11beta-HSD1-mediated cortisone reduction.	7-hydroxydehydroepiandrosterone	4-23	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	51-57
16603347-8	2006	The 7alpha-hydroxy-DHEA produced by the cytochrome CYP7B1 in tissues may exert anti-glucocorticoid effects through interference with the 11beta-HSD1-mediated cortisone reduction.	Cortisone	158-167	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	51-57
10588945-3	1999	In contrast to the liver-specific expression of CYP7A1, CYP7B1 mRNA transcripts were detected in human tissues involved in steroid genesis (brain, testes, ovary, and prostate) and in bile acid synthesis (liver) and reabsorption (colon, kidney, and small intestine).	Bile Acids and Salts	183-192	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	56-62
11971935-7	2002	Accumulation of 27-hydroxycholesterol in human atheroma is puzzling and may reflect low levels of oxysterol 7alpha-hydroxylase activity in human macrophages.	27-hydroxycholesterol	16-37	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	98-126
10588945-1	1999	Oxysterol 7alpha-hydroxylase has broad substrate specificity for sterol metabolites and may be involved in many metabolic processes including bile acid synthesis and neurosteroid metabolism.	Bile Acids and Salts	142-151	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-28
10588945-2	1999	The cloned human oxysterol 7alpha-hydroxylase (CYP7B1) cDNA encodes a polypeptide of 506 amino acid residues that shares 40% sequence identity to human cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver.	Cholesterol	152-163	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	17-45
15003524-1	2004	Oxysterol 7alpha-hydroxylase (CYP7B1) metabolizes oxysterols, potent regulators of lipid homeostasis.	Oxysterols	50-60	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-28
15003524-1	2004	Oxysterol 7alpha-hydroxylase (CYP7B1) metabolizes oxysterols, potent regulators of lipid homeostasis.	Oxysterols	50-60	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	30-36
15003524-3	2004	The present results indicate that sterol response element binding protein (SREBP), a family of oxysterol-responsive transcription factors that stimulates cholesterol synthesis, may be an important regulator of CYP7B1.	Sterols	34-40	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	210-216
15003524-3	2004	The present results indicate that sterol response element binding protein (SREBP), a family of oxysterol-responsive transcription factors that stimulates cholesterol synthesis, may be an important regulator of CYP7B1.	Oxysterols	95-104	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	210-216
15003524-3	2004	The present results indicate that sterol response element binding protein (SREBP), a family of oxysterol-responsive transcription factors that stimulates cholesterol synthesis, may be an important regulator of CYP7B1.	Cholesterol	154-165	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	210-216
15003524-8	2004	Our findings indicate that CYP7B1 transcription is controlled by SREBP and reveal a link between oxysterol-sensitive regulators and oxysterol metabolism.	Oxysterols	97-106	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	27-33
15003524-8	2004	Our findings indicate that CYP7B1 transcription is controlled by SREBP and reveal a link between oxysterol-sensitive regulators and oxysterol metabolism.	Oxysterols	132-141	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	27-33
15003524-9	2004	We propose that CYP7B1 is important for regulating cellular sterol content and protects against oxysterol-mediated toxicity.	Sterols	60-66	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	16-22
15003524-9	2004	We propose that CYP7B1 is important for regulating cellular sterol content and protects against oxysterol-mediated toxicity.	Oxysterols	96-105	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	16-22
12390533-0	2002	Characterization of the dehydroepiandrosterone (DHEA) metabolism via oxysterol 7alpha-hydroxylase and 17-ketosteroid reductase activity in the human brain.	Dehydroepiandrosterone	24-46	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	69-97
12390533-0	2002	Characterization of the dehydroepiandrosterone (DHEA) metabolism via oxysterol 7alpha-hydroxylase and 17-ketosteroid reductase activity in the human brain.	Dehydroepiandrosterone	48-52	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	69-97
11470525-1	2001	Oxysterol 7 alpha-hydroxylase catalyzes hydroxylation of oxysterols and neurosterols and plays a role in the alternative bile acid synthesis pathway.	Oxysterols	57-67	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-29
11470525-1	2001	Oxysterol 7 alpha-hydroxylase catalyzes hydroxylation of oxysterols and neurosterols and plays a role in the alternative bile acid synthesis pathway.	Bile Acids and Salts	121-130	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-29
11470525-8	2001	Thus, regulation of CYP7B1 transcription by Sp1 may play a pivotal role in regulating oxysterol levels, which regulate cholesterol metabolism.	Oxysterols	86-95	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	20-26
11470525-8	2001	Thus, regulation of CYP7B1 transcription by Sp1 may play a pivotal role in regulating oxysterol levels, which regulate cholesterol metabolism.	Cholesterol	119-130	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	20-26
11385071-5	2001	In liver, cholesterol feeding reduced cholesterol 7alpha-hydroxylase activity and mRNA level, and stimulated sterol 27-hydroxylase and oxysterol 7alpha-hydroxylase activities.	Cholesterol	10-21	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	135-163
10588945-3	1999	In contrast to the liver-specific expression of CYP7A1, CYP7B1 mRNA transcripts were detected in human tissues involved in steroid genesis (brain, testes, ovary, and prostate) and in bile acid synthesis (liver) and reabsorption (colon, kidney, and small intestine).	Steroids	123-130	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	56-62
10588945-2	1999	The cloned human oxysterol 7alpha-hydroxylase (CYP7B1) cDNA encodes a polypeptide of 506 amino acid residues that shares 40% sequence identity to human cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver.	Cholesterol	152-163	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	47-53
10588945-2	1999	The cloned human oxysterol 7alpha-hydroxylase (CYP7B1) cDNA encodes a polypeptide of 506 amino acid residues that shares 40% sequence identity to human cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver.	Bile Acids and Salts	254-264	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	17-45
10588945-2	1999	The cloned human oxysterol 7alpha-hydroxylase (CYP7B1) cDNA encodes a polypeptide of 506 amino acid residues that shares 40% sequence identity to human cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver.	Bile Acids and Salts	254-264	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	47-53
10588945-4	1999	The human oxysterol 7alpha-hydroxylase transiently expressed in 293/T cells was able to catalyze 7alpha-hydroxylation of 27-hydroxycholesterol and dehydroepiandrosterone (DHEA).	27-hydroxycholesterol	121-142	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	10-38
10588945-4	1999	The human oxysterol 7alpha-hydroxylase transiently expressed in 293/T cells was able to catalyze 7alpha-hydroxylation of 27-hydroxycholesterol and dehydroepiandrosterone (DHEA).	Dehydroepiandrosterone	147-169	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	10-38
10588945-4	1999	The human oxysterol 7alpha-hydroxylase transiently expressed in 293/T cells was able to catalyze 7alpha-hydroxylation of 27-hydroxycholesterol and dehydroepiandrosterone (DHEA).	Dehydroepiandrosterone	171-175	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	10-38
9802883-0	1998	Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease.	Bile Acids and Salts	40-49	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	77-105
9802883-1	1998	We describe a metabolic defect in bile acid synthesis involving a deficiency in 7alpha-hydroxylation due to a mutation in the gene for the microsomal oxysterol 7alpha-hydroxylase enzyme, active in the acidic pathway for bile acid synthesis.	Bile Acids and Salts	34-43	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	150-178
9802883-1	1998	We describe a metabolic defect in bile acid synthesis involving a deficiency in 7alpha-hydroxylation due to a mutation in the gene for the microsomal oxysterol 7alpha-hydroxylase enzyme, active in the acidic pathway for bile acid synthesis.	Bile Acids and Salts	220-229	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	150-178
34946825-3	2021	Hereditary spastic paraplegia (HSP) gene analysis identified the compound heterozygous mutations c.825T>A (pTyr275*) and c.1193C>T (pPro398Leu) in CYP7B1 gene.	ptyr275	107-114	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	147-153
34946825-3	2021	Hereditary spastic paraplegia (HSP) gene analysis identified the compound heterozygous mutations c.825T>A (pTyr275*) and c.1193C>T (pPro398Leu) in CYP7B1 gene.	ppro398leu	132-142	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	147-153
33345295-8	2021	We measured mRNA and protein levels of CYP7B1 in autopsy brain samples KEY RESULTS: The correlation between CSF-levels of 27OH and QAlb was higher in males while, with 7Hoca, the correlation was higher in females.	27-hydroxycholesterol	122-126	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	39-45
35379924-5	2022	In contrast, Cyp7B1 knockdown enhanced the effect of cholesterol on LAC cells proliferation and invasion.	Cholesterol	53-64	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	13-19
33849447-12	2021	CONCLUSIONS: In summary, these findings highlight that the phenotype of CYP7B1 deficiency varies widely, even in siblings and that early administration of chenodeoxycholic acid may improve prognosis.	Chenodeoxycholic Acid	155-176	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	72-78
32788687-7	2021	CYP7B1, an enzyme intrinsic to DHEA metabolism, was upregulated in PMD across experimental conditions (F(1,45) = 19.93, p < 0.0001).	Dehydroepiandrosterone	31-35	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	0-6
33024080-8	2020	Furthermore, we detected the suppressed activity of CYP7B1 enzyme readily metabolizing the precursors of sex hormones on one hand but increased anti-glucocorticoid effect of 7alpha-hydroxy-DHEA via competition with cortisone for HSD11B1 on the other.	7alpha-Hydroxydehydroepiandrosterone	174-193	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	52-58
33024080-8	2020	Furthermore, we detected the suppressed activity of CYP7B1 enzyme readily metabolizing the precursors of sex hormones on one hand but increased anti-glucocorticoid effect of 7alpha-hydroxy-DHEA via competition with cortisone for HSD11B1 on the other.	Cortisone	215-224	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	52-58
32501835-6	2020	An increased expression of CH25H and of a number of genes involved in cholesterol metabolism (ABCA1, ABCG1, CYP7B1, LXRalpha, OSBP, PPARgamma, SCARB1) was observed as well; this, was associated with a reduced susceptibility to in vitro HIV-1-infection of PBMCs and MDMs (p<0.01).	Cholesterol	70-81	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	108-114