PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28116308-2	2017	UA increases high mobility group box chromosomal protein 1 (HMGB1) expression and extracellular release in endothelial cells.	Uric Acid	0-2	structure specific recognition protein 1	Homo sapiens	13-36
28082391-5	2017	In vitro binding of purified SSRP1 or its isolated CID domain to a methylated DNA fragment containing alternating purine/pyrimidines, which is prone to Z-DNA transition, is much stronger than to other types of DNA.	Pyrimidines	121-132	structure specific recognition protein 1	Homo sapiens	29-34
28082391-4	2017	Histone chaperone FACT binds rapidly to the same regions via the SSRP1 subunit in curaxin-treated cells.	curaxin	82-89	structure specific recognition protein 1	Homo sapiens	65-70
28082391-5	2017	In vitro binding of purified SSRP1 or its isolated CID domain to a methylated DNA fragment containing alternating purine/pyrimidines, which is prone to Z-DNA transition, is much stronger than to other types of DNA.	purine	114-120	structure specific recognition protein 1	Homo sapiens	29-34
26702616-0	2015	Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1.	Methotrexate	53-65	structure specific recognition protein 1	Homo sapiens	139-162
27525970-0	2016	Blockage of SSRP1/Ets-1/Pim-3 signalling enhances chemosensitivity of nasopharyngeal carcinoma to docetaxel in vitro.	Docetaxel	98-107	structure specific recognition protein 1	Homo sapiens	12-17
27525970-9	2016	Our data indicate that SSRP1/Ets-1/Pim-3 signalling is tightly associated with the proliferation, apoptosis, autophagy, invasion and clonogenicity of NPC cells, and blockage of this signalling facilitates chemosensitivity of the cells to docetaxel.	Docetaxel	238-247	structure specific recognition protein 1	Homo sapiens	23-28
26755331-6	2016	Furthermore, we demonstrated that SSRP1-modulated apoptosis process and its knockdown increased the sensitivity of HCC cells to doxorubicin, 5-Fluorouracil, and cisplatin.	Doxorubicin	128-139	structure specific recognition protein 1	Homo sapiens	34-39
26755331-6	2016	Furthermore, we demonstrated that SSRP1-modulated apoptosis process and its knockdown increased the sensitivity of HCC cells to doxorubicin, 5-Fluorouracil, and cisplatin.	Fluorouracil	141-155	structure specific recognition protein 1	Homo sapiens	34-39
26755331-6	2016	Furthermore, we demonstrated that SSRP1-modulated apoptosis process and its knockdown increased the sensitivity of HCC cells to doxorubicin, 5-Fluorouracil, and cisplatin.	Cisplatin	161-170	structure specific recognition protein 1	Homo sapiens	34-39
25028470-6	2014	Quinacrine decreased the level of active FACT subunit SSRP1 and suppressed NF-kappaB-dependent luciferase activity.	Quinacrine	0-10	structure specific recognition protein 1	Homo sapiens	54-59
25028470-7	2014	Knockdown of SSRP1 decreased cell growth and sensitized cells to erlotinib.	Erlotinib Hydrochloride	65-74	structure specific recognition protein 1	Homo sapiens	13-18
25028470-8	2014	Moreover, transcriptomic profiling showed that quinacrine or combination treatment significantly affected cell-cycle-related genes that contain binding sites for transcription factors that regulate SSRP1 target genes.	Quinacrine	47-57	structure specific recognition protein 1	Homo sapiens	198-203
19372586-10	2009	Finally, silencing of DNA-PKcs or SSRP1 by short hairpin RNA significantly increased the sensitivity of cancer cells to cisplatin.	Cisplatin	120-129	structure specific recognition protein 1	Homo sapiens	34-39
22021906-6	2012	PKC-iota directly associated and phosphorylated Cdk7 at T170 in a cell cycle-dependent manner, phosphorylating its downstream target, cdk2 at T160.	iota	4-8	structure specific recognition protein 1	Homo sapiens	142-146
19372586-6	2009	In contrast, the SSRP1 association with the nucleolus was disrupted only by high (50-100 microg/mL) doses of cisplatin.	Cisplatin	109-118	structure specific recognition protein 1	Homo sapiens	17-22
21679440-10	2011	The structure specific recognition protein 1 (SSRP1), Spt16 and gammaH2AX appeared in the Ku86 complex 5 hours after cisplatin treatment.	Cisplatin	117-126	structure specific recognition protein 1	Homo sapiens	4-44
21679440-10	2011	The structure specific recognition protein 1 (SSRP1), Spt16 and gammaH2AX appeared in the Ku86 complex 5 hours after cisplatin treatment.	Cisplatin	117-126	structure specific recognition protein 1	Homo sapiens	46-51
21679440-14	2011	Silencing SSRP1 expression increased sensitivity to cisplatin and decreased gammaH2AX appearance.	Cisplatin	52-61	structure specific recognition protein 1	Homo sapiens	10-15
21679440-14	2011	Silencing SSRP1 expression increased sensitivity to cisplatin and decreased gammaH2AX appearance.	gammah2ax	76-85	structure specific recognition protein 1	Homo sapiens	10-15
21679440-15	2011	However, while silencing SSRP1 in cisplatin-treated cells increased both apoptosis and necrosis, DNA-PKcs silencing, in contrast, favored necrosis over apoptosis.	Cisplatin	34-43	structure specific recognition protein 1	Homo sapiens	25-30
19372586-7	2009	Both cisplatin-induced loss of nucleolar SSRP1 and DNA-PK activation are suppressed by pretreatment of the cells with wortmannin or the DNA-PK inhibitor NU7026 but not by the phosphatidylinositol 3-kinase inhibitor LY294002.	Cisplatin	5-14	structure specific recognition protein 1	Homo sapiens	41-46
11514569-0	2001	Effects of spectator ligands on the specific recognition of intrastrand platinum-DNA cross-links by high mobility group box and TATA-binding proteins.	Platinum	72-80	structure specific recognition protein 1	Homo sapiens	100-123
19372586-7	2009	Both cisplatin-induced loss of nucleolar SSRP1 and DNA-PK activation are suppressed by pretreatment of the cells with wortmannin or the DNA-PK inhibitor NU7026 but not by the phosphatidylinositol 3-kinase inhibitor LY294002.	Wortmannin	118-128	structure specific recognition protein 1	Homo sapiens	41-46
19372586-7	2009	Both cisplatin-induced loss of nucleolar SSRP1 and DNA-PK activation are suppressed by pretreatment of the cells with wortmannin or the DNA-PK inhibitor NU7026 but not by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(morpholin-4-yl)benzo(h)chromen-4-one	153-159	structure specific recognition protein 1	Homo sapiens	41-46
19372586-7	2009	Both cisplatin-induced loss of nucleolar SSRP1 and DNA-PK activation are suppressed by pretreatment of the cells with wortmannin or the DNA-PK inhibitor NU7026 but not by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	structure specific recognition protein 1	Homo sapiens	41-46
19372586-9	2009	Furthermore, RNA silencing of DNA-PKcs blocked the cisplatin-induced exit of nucleolar SSRP1.	Cisplatin	51-60	structure specific recognition protein 1	Homo sapiens	87-92
18953944-1	2008	OBJECTIVE: To investigate the release and intracellular localization of high mobility group box chromosomal protein 1 (HMGB1) in the peripheral blood monocytes of rheumatoid arthritis (RA) patients and the inhibitive effect of thalidomide.	Thalidomide	227-238	structure specific recognition protein 1	Homo sapiens	72-95
15659405-6	2005	Mutagenesis of the three serines revealed that serine 510 was more important for the regulation of SSRP1 DNA-binding activity.	Serine	25-32	structure specific recognition protein 1	Homo sapiens	99-104
15659405-6	2005	Mutagenesis of the three serines revealed that serine 510 was more important for the regulation of SSRP1 DNA-binding activity.	Serine	25-31	structure specific recognition protein 1	Homo sapiens	99-104
12393879-0	2002	p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.	Serine	4-10	structure specific recognition protein 1	Homo sapiens	102-107
11514569-6	2001	Double-stranded oligonucleotides containing the AG*G*C sequence, where the asterisks denote the sites of platination, with different spectator ligands are only moderately discriminated by the HMGB proteins and TBP, but the recognition of dsTG*G*A is highly dependent on the ligands.	Oligonucleotides	16-32	structure specific recognition protein 1	Homo sapiens	192-196
35048565-5	2022	The pyruvate produced by PKM2 directly binds to SSRP1, which increases the association of FACT complex with gammaH2AX and subsequently facilitates FACT-mediated chromatin loading of gammaH2AX, ultimately promoting DNA repair and tumor cell survival.	Pyruvic Acid	4-12	structure specific recognition protein 1	Homo sapiens	48-53
11344167-0	2001	Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin.	Cisplatin	118-127	structure specific recognition protein 1	Homo sapiens	21-26
11344167-0	2001	Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin.	Cisplatin	118-127	structure specific recognition protein 1	Homo sapiens	72-77
11344167-1	2001	The structure-specific recognition protein SSRP1, initially isolated from expression screening of a human B-cell cDNA library for proteins that bind to cisplatin (cis-diamminedichloroplatinum(II))-modified DNA, contains a single DNA-binding high mobility group (HMG) domain.	Cisplatin	152-161	structure specific recognition protein 1	Homo sapiens	43-48
11344167-1	2001	The structure-specific recognition protein SSRP1, initially isolated from expression screening of a human B-cell cDNA library for proteins that bind to cisplatin (cis-diamminedichloroplatinum(II))-modified DNA, contains a single DNA-binding high mobility group (HMG) domain.	Cisplatin	163-191	structure specific recognition protein 1	Homo sapiens	43-48
11344167-3	2001	The affinity and specificity of FACT, SSRP1, and the isolated HMG domain of SSRP1 for cisplatin-damaged DNA were investigated by gel mobility shift assays.	Cisplatin	86-95	structure specific recognition protein 1	Homo sapiens	76-81
11344167-6	2001	These results suggest that Spt16 primes SSRP1 for cisplatin-damaged DNA recognition by unveiling its HMG domain.	Cisplatin	50-59	structure specific recognition protein 1	Homo sapiens	40-45
11344167-7	2001	As expected, the isolated HMG domain of SSRP1 is sufficient for specific binding to cisplatin-damaged DNA and binds the major cisplatin 1,2-d(GpG) intrastrand cross-link.	Cisplatin	84-93	structure specific recognition protein 1	Homo sapiens	40-45
11344167-7	2001	As expected, the isolated HMG domain of SSRP1 is sufficient for specific binding to cisplatin-damaged DNA and binds the major cisplatin 1,2-d(GpG) intrastrand cross-link.	cisplatin 1,2-d	126-141	structure specific recognition protein 1	Homo sapiens	40-45
11344167-7	2001	As expected, the isolated HMG domain of SSRP1 is sufficient for specific binding to cisplatin-damaged DNA and binds the major cisplatin 1,2-d(GpG) intrastrand cross-link.	guanylyl-(3'-5')-guanosine	142-145	structure specific recognition protein 1	Homo sapiens	40-45
1372440-0	1992	Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin.	Cisplatin	183-192	structure specific recognition protein 1	Homo sapiens	63-86
1372440-1	1992	Human cDNA clones encoding a structure-specific recognition protein, SSRP1, that binds specifically to DNA modified with cisplatin have been isolated and characterized.	Cisplatin	121-130	structure specific recognition protein 1	Homo sapiens	69-74
33688504-4	2021	Methods: This study investigated the expression of SSRP1 in HCCDB, Oncomine, HPA, and other databases.	hccdb	60-65	structure specific recognition protein 1	Homo sapiens	51-56
33688504-4	2021	Methods: This study investigated the expression of SSRP1 in HCCDB, Oncomine, HPA, and other databases.	oncomine	67-75	structure specific recognition protein 1	Homo sapiens	51-56
30747224-5	2019	In addition, the overexpression of miR-135a mimics decreased the protein levels of GATA-3 and thymocyte selection-associated high mobility group box (TOX).	mir-135a	35-43	structure specific recognition protein 1	Homo sapiens	125-148
31775157-8	2020	SSRP1 also contributes to DNA binding, and can assume two conformations, depending on whether a second H2A-H2B dimer is present.	Hydrogen	103-110	structure specific recognition protein 1	Homo sapiens	0-5
30762286-9	2019	Furthermore, SSRP1 induced apoptosis and SSRP1 knockdown augmented the sensitivity of CRC cells to 5-fluorouracil and cisplatin.	Fluorouracil	99-113	structure specific recognition protein 1	Homo sapiens	13-18
30762286-9	2019	Furthermore, SSRP1 induced apoptosis and SSRP1 knockdown augmented the sensitivity of CRC cells to 5-fluorouracil and cisplatin.	Fluorouracil	99-113	structure specific recognition protein 1	Homo sapiens	41-46
30762286-9	2019	Furthermore, SSRP1 induced apoptosis and SSRP1 knockdown augmented the sensitivity of CRC cells to 5-fluorouracil and cisplatin.	Cisplatin	118-127	structure specific recognition protein 1	Homo sapiens	41-46
30407547-3	2018	The High Mobility Group Box (HMGB) proteins may sensitize tumor cells to cisplatin by specifically binding to platinated DNA (PtDNA) lesions.	Cisplatin	73-82	structure specific recognition protein 1	Homo sapiens	4-27
30407547-3	2018	The High Mobility Group Box (HMGB) proteins may sensitize tumor cells to cisplatin by specifically binding to platinated DNA (PtDNA) lesions.	Cisplatin	73-82	structure specific recognition protein 1	Homo sapiens	29-33
29764934-2	2018	In the formation of this complex, structure-specific recognition protein-1 (SSRP1) heterodimerizes with suppressor of Ty 16 (SPT16).	Thr-Tyr	118-120	structure specific recognition protein 1	Homo sapiens	34-74
29764934-2	2018	In the formation of this complex, structure-specific recognition protein-1 (SSRP1) heterodimerizes with suppressor of Ty 16 (SPT16).	Thr-Tyr	118-120	structure specific recognition protein 1	Homo sapiens	76-81
28416484-3	2017	In this study, we show that SSRP1, but not SPT16, is critical for cell survival after ionizing radiation or methyl methanesulfonate-induced single-strand DNA damage.	Methyl Methanesulfonate	108-131	structure specific recognition protein 1	Homo sapiens	28-33