PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34904929-0	2021	ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer.	Glutamine	42-51	autophagy related 12	Mus musculus	0-5
33104985-6	2021	Compared with the control group, the expressions of key regulators of oocyte apoptosis (bax, caspase-3) and autophagy (lc3, beclin, ATG12) pathway were increased in the HCPT-treated group.	10-hydroxycamptothecin	169-173	autophagy related 12	Mus musculus	132-137
34904929-7	2021	In line, ATG12 loss is associated with absence of hypoxia, as determined by pimonidazole immunohistochemistry.	pimonidazole	76-88	autophagy related 12	Mus musculus	9-14
34904929-11	2021	We observed decreased intracellular L-glutamine levels in ATG12-deficient cells during hypoxia and increased cell killing after L-glutamine depletion, indicating a central role for ATG12 in maintaining L-glutamine homeostasis.	Glutamine	36-47	autophagy related 12	Mus musculus	58-63
34904929-11	2021	We observed decreased intracellular L-glutamine levels in ATG12-deficient cells during hypoxia and increased cell killing after L-glutamine depletion, indicating a central role for ATG12 in maintaining L-glutamine homeostasis.	Glutamine	36-47	autophagy related 12	Mus musculus	181-186
34904929-11	2021	We observed decreased intracellular L-glutamine levels in ATG12-deficient cells during hypoxia and increased cell killing after L-glutamine depletion, indicating a central role for ATG12 in maintaining L-glutamine homeostasis.	Glutamine	202-213	autophagy related 12	Mus musculus	58-63
34904929-11	2021	We observed decreased intracellular L-glutamine levels in ATG12-deficient cells during hypoxia and increased cell killing after L-glutamine depletion, indicating a central role for ATG12 in maintaining L-glutamine homeostasis.	Glutamine	202-213	autophagy related 12	Mus musculus	181-186
34462635-8	2021	Lastly, we showed that taxifolin suppressed tumors in mice; stimulated expression of autophagy-related genes LC3B-II, Atg7, atg12, and Beclin-1; and inhibited expression of fatty acid synthesis-related genes C/EBPalpha, PPARgamma, FABP4, and FAS.	taxifolin	23-32	autophagy related 12	Mus musculus	124-129
33159990-8	2021	Subsequently, our results showed that increased expression level of BAX protein, reduced expression of BCL-2 protein, ATG12 and LC3 protein expression increased in ovaries after Gly treatment.	glyphosate	178-181	autophagy related 12	Mus musculus	118-123
32948162-7	2020	Moreover, the HFD + EMfC treated group showed decreased transcript levels of autophagy-regulated genes including Atg4b, Atg5, Atg7 and Atg12.	emfc	20-24	autophagy related 12	Mus musculus	135-140
33396170-5	2021	Also, over-exposure to Cu increased mRNA and protein expressions of Beclin1, Atg12, Atg5, Atg16L1, Atg7, Atg3, and LC3 and decreased mRNA and protein expressions of p62.	Copper	23-25	autophagy related 12	Mus musculus	77-82
32910484-6	2020	Melatonin inhibited neuronal pyroptosis and excessive autophagy, as evidenced by decreased levels of NLRP3, cleaved caspase-1, GSDMD-N, IL-1beta, LC3, Beclin1, and ATG12 both in vivo and in vitro.	Melatonin	0-9	autophagy related 12	Mus musculus	164-169
32910484-7	2020	MicroRNA-214-3p (miR-214-3p) was decreased in DM mice and HG-treated cells, and such a downregulation was corrected by melatonin, which was accompanied by repression of caspase-1 and ATG12.	Melatonin	119-128	autophagy related 12	Mus musculus	183-188
32910484-9	2020	Our results indicate that melatonin exhibits a neuroprotective effect by inhibiting neuronal pyroptosis and excessive autophagy through modulating the miR-214-3p/caspase-1 and miR-214-3p/ATG12 axes, respectively, and it might be a potential agent for the treatment of brain damage in the setting of DM.	Melatonin	26-35	autophagy related 12	Mus musculus	187-192
31885784-6	2019	The liver expressions of ATG5, ATG7, and ATG12 were significantly increased by genipin pretreatment in the ALI mice model.	genipin	79-86	autophagy related 12	Mus musculus	41-46
31844253-3	2020	In addition, using untargeted metabolomics with ATG12-deficient cancer cells, we observed a global reduction in cellular bioenergetic pathways, such as beta-oxidation (FAO), glycolysis, and tricarboxylic acid cycle activity, as well as a decrease in mitochondrial respiration as monitored with Seahorse experiments.	Tricarboxylic Acids	190-208	autophagy related 12	Mus musculus	48-53
31906147-8	2019	In neurons, celastrol enhances autophagy, autophagosome biogenesis (Beclin 1 , Ambra1 , Vps34 , Atg7 , Atg12 , and LC3-II ), and mitophagy (PINK1 , DJ-1 , and LRRK2 ), and these might be associated with MPAK signaling pathways.	celastrol	12-21	autophagy related 12	Mus musculus	103-108
31352102-9	2019	Meanwhile, the expression levels of autophagy-related genes (lc3, atg14, mtor) and proteins (LC3, Atg12) were significantly decreased in the glyphosate treatment group compared with the control group.	glyphosate	141-151	autophagy related 12	Mus musculus	98-103
30957679-5	2019	Exposure to CS increased the production of ROS and induced molecular changes in the autophagy pathway, including an increase in phosphorylated AMPK and ULK1, reduction in phosphorylated mTOR, and increases in SESN2, ATG12, and LC3B levels.	Cesium	12-14	autophagy related 12	Mus musculus	216-221
30551460-11	2019	Surprisingly, artesunate also evidently triggered ferritinophagy accompanied by up-regulation of LC3 (microtubule-associated protein light chain 3), Atg3, Atg5, Atg6/beclin1, Atg12 (autophagy related genes) and down-regulation of p62, FTH1 (ferritin heavy chain), NCOA4 (nuclear receptor co-activator 4) in activated HSCs.	Artesunate	14-24	autophagy related 12	Mus musculus	175-180
30816479-8	2019	Furthermore, curcumin or resveratrol significantly downregulated the expression of autophagy-related 12, Beclin-1 and microtubule-associated protein light chain 3 II, and upregulated the expression of phosphorylated mTOR and SIRT1 in the colon tissue, compared with those in the DSS-treated group.	Curcumin	13-21	autophagy related 12	Mus musculus	83-103
30816479-8	2019	Furthermore, curcumin or resveratrol significantly downregulated the expression of autophagy-related 12, Beclin-1 and microtubule-associated protein light chain 3 II, and upregulated the expression of phosphorylated mTOR and SIRT1 in the colon tissue, compared with those in the DSS-treated group.	Resveratrol	25-36	autophagy related 12	Mus musculus	83-103
29414645-9	2018	Attractively, Oroxylin A treatment also markedly up-regulated the expression of autophagy makers, LC3-B, Atg3, Atg4, Atg5, Beclin1/Atg6, Atg7, Atg9, ATG12, and Atg14, and apparently reduced the expression of autophagy substrate p62 in both CCl4-induced murine model of liver fibrosis and PDGF-BB-treated HSCs.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	14-24	autophagy related 12	Mus musculus	149-154
30131715-5	2018	The results revealed that MC-LR could induce cells apoptosis and morphologic changes in ovarian tissues, induce oxidative stress by stimulating the generation of reactive oxygen species (ROS), destroying antioxidant capacity, and subsequently trigger ERs and autophagy by inducing the hyper-expression of ATG12, ATG5, ATG16, EIF2alpha (phosphorylated at S51), CHOP, XBP1, GRP78, Beclin1, and PERK (Thr980).	mc-lr	26-31	autophagy related 12	Mus musculus	305-310
30131715-6	2018	Furthermore, NAC pretreatment partly inhibited MC-LR-induced ERs and autophagy via the PERK/ATG12 and XBP1/Beclin1 pathways.	Acetylcysteine	13-16	autophagy related 12	Mus musculus	92-97
30131715-6	2018	Furthermore, NAC pretreatment partly inhibited MC-LR-induced ERs and autophagy via the PERK/ATG12 and XBP1/Beclin1 pathways.	mc-lr	47-52	autophagy related 12	Mus musculus	92-97
28669590-9	2017	RESULTS: The results of Western blottings showed that TXA enhanced the production of autophagy-related proteins such as mitogen-activated protein kinases (MAPKs), extracellular signal-regulated kinase (ERK)1/2, Beclin-1, Atg12, and light chain 3 (LC3) I-II, whereas it decreased the synthesis of the mTOR complex.	Tranexamic Acid	54-57	autophagy related 12	Mus musculus	221-226
28440437-0	2017	Autophagy-related protein 12 associates with anti-apoptotic B cell lymphoma-2 to promote apoptosis in gentamicin-induced inner ear hair cell loss.	Gentamicins	102-112	autophagy related 12	Mus musculus	0-28
28510366-9	2017	Our further in vivo study confirmed that the expression of HMGA1, HMGA2, LC3II, Atg12-Atg5, Atg4, Atg5, Atg7, Atg10, Atg12, Beclin 1 were increased and p62 was reduced in lung tissues of Cr (VI)-treated BALB/c mice.	Chromium	187-189	autophagy related 12	Mus musculus	80-85
28440437-6	2017	Furthermore, it was indicated that the simultaneous expression and interaction of Atg12 with Bcl-2 following GM treatment co-integrated autophagy with apoptosis in the cochlea.	Gentamicins	109-111	autophagy related 12	Mus musculus	82-87
28440437-9	2017	Therefore, Atg12 may be a potential therapeutic target for the treatment of GM-induced cochlear hair loss.	Gentamicins	76-78	autophagy related 12	Mus musculus	11-16
28382029-8	2017	Ba induced autophagy by increasing the expression of Beclin1 and Atg5-Atg12-Atg16 complex, but not the AKT/mTOR signaling pathway.	Barium	0-2	autophagy related 12	Mus musculus	70-75
27793014-7	2016	Moreover, DHM exerted hepatoprotective effects by upregulating mRNA levels of various essential autophagy-related genes including ATG5, ATG12, BECN1, and LC3.	dihydromyricetin	10-13	autophagy related 12	Mus musculus	136-141
25663172-5	2015	Key proteins involved in initiating autophagy, such as beclin-1, and several Atg proteins involved in autophagosome maturation (Atg3, Atg5, Atg12 and Atg7), were also up-regulated on exposure to HDHA.	hdha	195-199	autophagy related 12	Mus musculus	140-145
25898131-6	2015	Using a clinically relevant mouse model of residual PC, we use tissue microarray (TMA) and immunohistochemistry (IHC) procedures to investigate the potential of polyphenol(s) to target ATG3, ATG5, ATG12, LC3A, LC3B, BECN1, and SURIVIN after clinical radiotherapy.	Polyphenols	161-171	autophagy related 12	Mus musculus	197-202
25550510-8	2015	Moreover, t-TUCB restored hepatic levels of Atg12-Atg5 and LC3-II conjugates and reduced p62 expression, indicating up-regulation of hepatic autophagy.	4-(4-(3-(4-trifluoromethoxy-phenyl)ureido)cyclohexyloxy)benzoic acid	10-16	autophagy related 12	Mus musculus	44-49
25661336-7	2015	The results revealed a reduction in the number of TNF-alpha-induced autophagosomes after ligustilide treatment accompanied by a decrease in Atg-7, Atg-5, Atg-12 and LC3B expression, as well as a reduction of the LC3BII/I ratio in a concentration-dependent manner.	ligustilide	89-100	autophagy related 12	Mus musculus	154-160
18849965-5	2008	Atg16L1-deficiency disrupts the recruitment of the Atg12-Atg5 conjugate to the isolation membrane, resulting in a loss of microtubule-associated protein 1 light chain 3 (LC3) conjugation to phosphatidylethanolamine.	phosphatidylethanolamine	190-214	autophagy related 12	Mus musculus	51-56
25585051-3	2015	Upon high-fat diet (HFD) consumption, mice lacking Atg12 in POMC-positive neurons exhibit accelerated weight gain, adiposity, and glucose intolerance, which is associated with increased food intake, reduced ambulation, and decreased LEP/leptin sensitivity.	Glucose	130-137	autophagy related 12	Mus musculus	51-56
25551567-6	2014	The treatment of mice with olanzapine for 14 d increased the brain levels of autophagosome-associated LC3B-II and mRNA encoding Atg4b, Atg5, Atg7, Atg12, Gabarap, and Becn1.	Olanzapine	27-37	autophagy related 12	Mus musculus	147-152
22896037-4	2012	This study demonstrated that autophagy proteins beclin-1, Atg5, and Atg12 were cleaved and degraded during the course of cisplatin injury in RTEC and the kidney.	Cisplatin	121-130	autophagy related 12	Mus musculus	68-73
22252008-7	2012	Surprisingly, however, in these experiments CQ sensitization occurred independent of autophagy inhibition, since sensitization was not mimicked by Atg12, Beclin 1 knockdown or bafilomycin treatment, and occurred even in the absence of Atg12.	Chloroquine	44-46	autophagy related 12	Mus musculus	235-240
24705402-7	2014	In diabetic mice, erlotinib-treated mice had evidence of increased renal autophagy, as indicated by altered expression and activity of ATG12, beclin, p62, and LC3A II, hallmarks of autophagy, and had decreased ER stress, as indicated by decreased expression of C/EBP homologous protein, binding immunoglobulin protein, and protein kinase RNA-like ER kinase.	Erlotinib Hydrochloride	18-27	autophagy related 12	Mus musculus	135-140