PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32592200-11	2020	Gene expression of IL10 and FABP4 increased in E2 + EM.	Estradiol	47-51	IL10	Sus scrofa	19-23
33592257-6	2021	Our results revealed that Cd caused cerebral histopathology lesions, inducing cerebral pyroptosis and the mass generation of inflammatory cytokines, as indicated by the increased NLRP3 inflammasome activation (NLRP3, Cas1 and ASC) and the upregulation of inflammation factors IL-2, IL-6, IL-7 and inhibition of IL-10.	Cadmium	26-28	IL10	Sus scrofa	311-316
31540325-8	2019	In addition, dietary succinate supplementation promoted the expression of inflammatory cytokines interleukin (IL)-25, IL-10, IL-8, and IL-18 in the jejunum.	Succinic Acid	21-30	IL10	Sus scrofa	118-123
32456524-6	2020	Co-culture cells challenged with gamma-irradiated M.Tb under various conditions resulted in high interleukin (IL)-10 secretion and high percentage of PD1 expression on CD8 T cells, which might be due to defective antigen presentation of TAP on dendritic cells and macrophages.	Terbium	52-54	IL10	Sus scrofa	97-116
32015495-12	2020	Pigs in Amervac, Ingelvac MLV and Ingelvac ATP groups had significantly higher levels of IL-10 compared to Porcilis, Fostera and Prime Pac groups at 7 and 14 DPV.	Adenosine Triphosphate	43-46	IL10	Sus scrofa	89-94
32751572-7	2020	Pharmacological zinc increased IL-1RA:IL-1 ratio by 42% compared with basal zinc, while carbadox tended to increase the IL-10 and IL10:IL-12 ratio compared with non-carbadox.	Carbadox	88-96	IL10	Sus scrofa	120-125
32751572-7	2020	Pharmacological zinc increased IL-1RA:IL-1 ratio by 42% compared with basal zinc, while carbadox tended to increase the IL-10 and IL10:IL-12 ratio compared with non-carbadox.	Carbadox	88-96	IL10	Sus scrofa	130-134
32568258-6	2020	N-acetylcysteine increased the number of immune cells and decreased TNF-alpha production after cyclophosphamide injection and decreased TNF-alpha, IFN-gamma, NF-kappaB, and IL-8 expression and increased IL-10 expression in peripheral blood mononuclear cells.	Acetylcysteine	0-16	IL10	Sus scrofa	203-208
32122615-5	2020	In addition, the chitosan nanovaccine induced the proliferation of antigen-specific IFNgamma secreting T-helper/memory and gammadelta T cells compared to control poly(I:C) group; and an increased Th1 (IFNgamma, IL-6 and IL-2) and Th2 (IL-10 and IL-13) cytokines mRNA expression in the tracheobronchial lymph nodes compared to lymphoid tissues obtained from pigs given commercial influenza vaccine.	nanovaccine	26-37	IL10	Sus scrofa	235-240
30106205-10	2018	CONCLUSIONS: We demonstrated that IL-10 production is largely mediated through the recognition of Bb12 structures by TLR2, as bacterial metabolites in the culture supernatant failed to induce IL-10 expression.	bb12	98-102	IL10	Sus scrofa	34-39
28948563-6	2018	Compared with control and Se-alone treatments, DON exposure significantly and dose dependently decreased the expression levels of IL-2, IL-4, IL-6, IL-10, IFN-gamma, IgG, and IgM mRNA and protein.	deoxynivalenol	47-50	IL10	Sus scrofa	148-153
30106205-9	2018	Bacterial cell wall components were responsible for Bb12-induced IL-10 production since no IL-10 was detected in the culture supernatant.	bb12	52-56	IL10	Sus scrofa	65-70
29268571-8	2018	CONCLUSION: The present results are interpreted to suggest that dietary ZnO provided by SZ may play a role in intestinal mucosal growth and immune function by modulating the expression of IGF-I, IL-6, and IL-10 genes.	Zinc Oxide	72-75	IL10	Sus scrofa	205-210
27782738-8	2017	Colonic concentration and mRNA abundance of IL-10 were reduced (p<0.05), however, jejunal IL-10 mRNA abundance was increased (p<0.05) in the DSS group compared with the control group.	dss	147-150	IL10	Sus scrofa	44-49
29288900-7	2018	After an 8-12-week treatment with prednisolone, the percentages of PD-1+, PD-1+CD154+, and PD-1+IL-21+ Tfh cells as well as the serum level of IL-21 were significantly reduced; in contrast, the serum levels of IL-4 and IL-10 were increased (P < 0.05).	Prednisolone	34-46	IL10	Sus scrofa	219-224
28821806-6	2017	Furthermore, infected children had more phenotypically exhausted PD-1+ CD4+ T cells, more Tregs expressing TNF-RII, and higher IL-10 responses to PfRBCs, which persisted following resolution of infection.	pfrbcs	146-152	IL10	Sus scrofa	127-132
27782738-8	2017	Colonic concentration and mRNA abundance of IL-10 were reduced (p<0.05), however, jejunal IL-10 mRNA abundance was increased (p<0.05) in the DSS group compared with the control group.	dss	147-150	IL10	Sus scrofa	93-98
27782738-9	2017	In conclusion, administration of DSS at 1.25 g/kg BW for 10 days respectively induced acute inflammation in the jejunum and chronic inflammation and ulcerative colitis in the colon with substantially decreased colonic concentration and mRNA abundance of IL-10 in the young pigs, mimicking the IL-10 expression pattern in humans Associated with chronic bowel inflammation.	dss	33-36	IL10	Sus scrofa	254-259
27782738-9	2017	In conclusion, administration of DSS at 1.25 g/kg BW for 10 days respectively induced acute inflammation in the jejunum and chronic inflammation and ulcerative colitis in the colon with substantially decreased colonic concentration and mRNA abundance of IL-10 in the young pigs, mimicking the IL-10 expression pattern in humans Associated with chronic bowel inflammation.	dss	33-36	IL10	Sus scrofa	293-298
28300194-8	2017	COS supplementation had both increased (P < 0.05) SOD, CAT and T-AOC activities and elevated (P < 0.05) IL-10, IgG and IgM concentrations in the amniotic fluid.	carbonyl sulfide	0-3	IL10	Sus scrofa	110-115
27271180-12	2016	Vitamin D supplementation significantly decreased serum levels of TNF-alpha and IFN-gamma, upregulated serum levels of IL-10, and had no effect on serum IL-6 levels.	Vitamin D	0-9	IL10	Sus scrofa	119-124
28159239-6	2017	Interestingly, the IL-10 production was further stimulated by DAN treatment in the LPS challenged piglet.	danofloxacin	62-65	IL10	Sus scrofa	19-24
29296695-6	2016	Low oxygen levels decrease T-cell proliferation, promote glycolysis, and cause the appearance of a population of PD-1+ and IL-10-secreting T cells.	Oxygen	4-10	IL10	Sus scrofa	123-128
28170426-10	2017	In contrast CSS induced a marked upregulation of mRNA for IL10 and mast cell chymase gene (CMA1) in the ileum and colon.	thiocysteine	12-15	IL10	Sus scrofa	58-62
25774662-7	2015	Additionally, expression of some markers of immunoregulatory activity (IL-10, IL-2Ralpha) were decreased in EB-stained capsules.	Evans Blue	108-110	IL10	Sus scrofa	71-76
26347944-4	2015	However, treatment with an inhibitor of GSK3beta, lithium chloride, significantly increased the production of IL-10 and IL-12 compared with the untreated control and significantly decreased the production of IL-10 and IL-12 compared with LPS stimulation.	Lithium Chloride	50-66	IL10	Sus scrofa	110-115
26347944-4	2015	However, treatment with an inhibitor of GSK3beta, lithium chloride, significantly increased the production of IL-10 and IL-12 compared with the untreated control and significantly decreased the production of IL-10 and IL-12 compared with LPS stimulation.	Lithium Chloride	50-66	IL10	Sus scrofa	208-213
26812324-8	2016	Furthermore, supplementation with SDCP reduced ( < 0.05) the concentration of IL-10 and upregulated ( < 0.05) the mRNA levels of GLP-2, mucin 2 (MUC2), and trefoil factor family 3 (TFF3) in the ileum compared with feeding CON.	sdcp	34-38	IL10	Sus scrofa	81-86
23933333-8	2013	Pigs vaccinated with MLV+H9e had lower frequency of T-regulatory cells and IL-10 production but higher frequency of Th/memory cells and IFN-gamma secretion than that in pigs vaccinated with MLV alone.	CHEMBL4474291	21-24	IL10	Sus scrofa	75-80
26020885-11	2015	The concentrations of IL-10 (duodenum, jejunum, and ileum) and secretory immunoglobulin (SIgA; duodenum and ileum) were higher in piglets fed the COS-supplemented diet compared with control ( < 0.05).	oligochitosan	146-149	IL10	Sus scrofa	22-27
25269024-10	2014	Sevoflurane also reverted the lung IR-induced decrease in IL-10 expression.	Sevoflurane	0-11	IL10	Sus scrofa	58-63
24930695-13	2014	Microglia cells respond to Poly I:C stimulation in a concentration-dependent manner with the induction of IL-1ss, IL-6, TNFalpha, Cox2, iNOS and, to a lesser degree, IL-10.	Poly I-C	27-35	IL10	Sus scrofa	166-171
24975830-7	2014	Treatment with prednisone or/and immunosuppressive drugs significantly reduced the frequency of CD4(+)CXCR5(+), CD4(+)CXCR5(+)PD-1(+) TFH cells and serum IL-21 level, but increased IL-4 and IL-10 levels in the patients.	Prednisone	15-25	IL10	Sus scrofa	190-195
24674595-8	2014	CL9 also promoted host defensive responses by decreasing IL-8 and increasing IL-10 production in IPEC-J2 cells and expression of antimicrobial peptide genes clec-60, clec-85 in C. elegans.	Cladribine	0-3	IL10	Sus scrofa	77-82
24333338-4	2014	Treatment with prednisone significantly reduced the frequency of CD4(+)CXCR5(+) and CD4(+)CXCR5(+)PD-1(+) TFH cells and the levels of serum IL-21, but increased IL-4 and IL-10 in those patients.	Prednisone	15-25	IL10	Sus scrofa	170-175
26063974-8	2015	Inhibition of Notch signaling by N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenyl glycinet-butyl ester (DAPT) induced significantly decreased expressions of PD-1 and IL-10 in the LPS-tolerant cell model.	n-[n-(3,5-difluorophenacetyl)-l-alanyl]-s-phenyl glycinet-butyl ester	33-102	IL10	Sus scrofa	166-171
26063974-8	2015	Inhibition of Notch signaling by N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenyl glycinet-butyl ester (DAPT) induced significantly decreased expressions of PD-1 and IL-10 in the LPS-tolerant cell model.	dapt	104-108	IL10	Sus scrofa	166-171
25638976-7	2014	The results of the study indicate that ZEN inhibits IL-2 and IFN-gamma secretion and stimulates IL-4 and IL-10 produc- tion by Th1 and Th2 lymphocytes by shifting the Th1/Th2 balance towards the humoral immune response.	Zearalenone	39-42	IL10	Sus scrofa	105-110
24148869-3	2013	Naloxone pretreatment blocked the suppressive effects of the restraint on NKCC and IL-12 and altered IL-10, IL-6, TNF-alpha, PRL and ACTH concentrations.	Naloxone	0-8	IL10	Sus scrofa	101-106
22357743-7	2012	High dietary fCP increased (P < 0.05) expression of PCNA, IL1beta, IL10, TGFbeta, MUC1, MUC2, and MUC20, irrespective of fCHO concentration.	3-amino-4-fluorocyclopentane-1-carboxylic acid	13-16	IL10	Sus scrofa	70-74
22558153-13	2012	The number of CD4+/CD25+ regulatory T-cells and IL-10 expressions in the circulating blood significantly increased in the MSC-CsA group compared to the other groups.	Cyclosporine	126-129	IL10	Sus scrofa	48-53
21386995-9	2011	The frequency of ASA-specific IFN-gamma-secreting peripheral blood mononuclear cells, as well as the amount of IL-10 produced by ASA-specific cells, was of greater magnitude in probiotic-fed pigs compared to control animals.	Aspirin	129-132	IL10	Sus scrofa	111-116
20139271-5	2010	Stimulation with PMA/ionomycin caused splenic CD4(+)PD-1(+) T cells to secrete high levels of IFN-gamma, IL-10, low levels of TNF-alpha, faint levels of IL-2, IL-21, and no IL-4, IL-17.	Tetradecanoylphorbol Acetate	17-20	IL10	Sus scrofa	105-110
20872347-8	2010	BAK treatment, however, resulted in a significant decline in IL-6/IL-10 ratios.	bakuchiol	0-3	IL10	Sus scrofa	66-71
20139271-5	2010	Stimulation with PMA/ionomycin caused splenic CD4(+)PD-1(+) T cells to secrete high levels of IFN-gamma, IL-10, low levels of TNF-alpha, faint levels of IL-2, IL-21, and no IL-4, IL-17.	Ionomycin	21-30	IL10	Sus scrofa	105-110
18585769-11	2008	ODE-challenged MDMs had significantly diminished cytokine responses (TNF-alpha, IL-6, and IL-10) after repeat challenge with high-dose ODE.	4-O-amino-phenol-4'-demethylepipodophyllotoxin ether	0-3	IL10	Sus scrofa	90-95
19346007-4	2009	Regarding cytokine production, vitamin E consistently decreases the mRNA expression and the percentage of cells producing IL-10.	Vitamin E	31-40	IL10	Sus scrofa	122-127
19346007-6	2009	In conclusion, our results revealed that vitamin E is able to suppress IL-10 production and to influence the production of IL-2, IL-4, and maybe TBX21.	Vitamin E	41-50	IL10	Sus scrofa	71-76
17897547-18	2007	In group steroid treatment, the changes of the cytokines were mainly the increase of IL-10 and IL-4, the concentration of IFN and TNF was decreased.	Steroids	9-16	IL10	Sus scrofa	85-90
12052345-9	2002	At both 12 and 24 h, IL-10 was reduced by 300 nM DEX and by 150 and 300 nM CORT (P<0.05).	Dexamethasone	49-52	IL10	Sus scrofa	21-26
16836739-8	2006	In this model of porcine endotoxic shock, LPHF was responsible for a significant clearance of IL-6 (20 mL/min) and Il-10 (14 mL/min), and for an improvement in RV-vascular coupling.	lphf	42-46	IL10	Sus scrofa	115-120
15730135-1	2005	The expression of mRNA encoding interleukin (IL)-10, IL-12p35 and IL-12p40 was studied, by reverse transcription-polymerase chain reaction and by in situ hybridization with a non-radioactive digoxigenin-labelled cDNA probe, in formalin-fixed, paraffin-wax-embedded lung tissue from pigs experimentally infected with Actinobacillus pleuropneumoniae.	Formaldehyde	227-235	IL10	Sus scrofa	32-51
12052345-13	2002	None of the steroid treatments affected IFNgamma, but 300 nM DEX reduced IL-10 (P<0.05).	Dexamethasone	61-64	IL10	Sus scrofa	73-78
34386930-7	2021	For in vivo studies, overexpression of miR-4458 hindered tumor growth, decreased the proportion of PD-1+ T cells, the expression of PD-L1 and IL-10, upregulated the proportion of CD4+ T, CD8+ T cells as well as the expression of IFN-gamma and IL-2, which were all reversed by overexpression of STAT3, and the effects of STAT3 were counteracted after knockdown of PD-L1.	mir-4458	39-47	IL10	Sus scrofa	142-147
34626868-5	2021	The IL-10 protein abundance in the tissue was less when there was inclusions of pioglitazone in the medium, while the treatment with T0070907 resulted in a larger abundance of NF-kappaB, IL-1beta (in the tissue) and IL-4 (in tissue and culture media).	Pioglitazone	80-92	IL10	Sus scrofa	4-9
34626868-5	2021	The IL-10 protein abundance in the tissue was less when there was inclusions of pioglitazone in the medium, while the treatment with T0070907 resulted in a larger abundance of NF-kappaB, IL-1beta (in the tissue) and IL-4 (in tissue and culture media).	T 0070907	133-141	IL10	Sus scrofa	4-9
34626868-6	2021	During the gestational period, pioglitazone or PGJ2 suppressed mRNA IFNgamma and IL-10 transcript and protein abundances (in the tissue and culture media), whereas there was an enhanced NF-kappaB protein abundance (in the tissue).	Pioglitazone	31-43	IL10	Sus scrofa	81-86
34626868-6	2021	During the gestational period, pioglitazone or PGJ2 suppressed mRNA IFNgamma and IL-10 transcript and protein abundances (in the tissue and culture media), whereas there was an enhanced NF-kappaB protein abundance (in the tissue).	9-deoxy-delta-9-prostaglandin D2	47-51	IL10	Sus scrofa	81-86
34415185-6	2021	Macrophages treated with CBSC medium in vitro polarized to a pro-reparative phenotype characterized by increased CD206 expression, increased efferocytic ability, increased IL-10, TGF-b, and IL-1RA secretion, and increased mitochondrial respiration.	cbsc medium	25-36	IL10	Sus scrofa	172-177
35348632-7	2022	IL10 protein was localized to luminal epithelial (LE), stromal cells, and macrophages; IL10RA protein to LE, endothelial, stromal, and T cells; and IL10RB mRNA to LE cells in the endometrium.	Phenobarbital	30-37	IL10	Sus scrofa	0-4
35549669-9	2022	Tacrolimus pretreatment prevented increases in the interleukin (IL)-6-to-IL-10 ratio, vascular cell adhesion molecule-1, circulating levels of IL-1beta, IL-6-to-IL-10 ratio and glycocalyx-derived molecules.	Tacrolimus	0-10	IL10	Sus scrofa	73-78
35549669-9	2022	Tacrolimus pretreatment prevented increases in the interleukin (IL)-6-to-IL-10 ratio, vascular cell adhesion molecule-1, circulating levels of IL-1beta, IL-6-to-IL-10 ratio and glycocalyx-derived molecules.	Tacrolimus	0-10	IL10	Sus scrofa	161-166
35154155-6	2022	More importantly, previous administration of alpha-tocopherol increased the production of IL-10 by T and myeloid suppressor cells and the formation of effector memory T cells while decreasing the expression of PD-1 on T cells.	alpha-Tocopherol	45-61	IL10	Sus scrofa	90-95