PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
3013258-1	1986	Aflatoxins B1, B2, G1, G2, and M1 have been evaluated for activity toward cytochrome oxidase in isolated rat liver mitochondria employing ferrocytochrome c and p-phenylene diamine as reductants.	Carbon	59-60	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	11-33
2508757-2	1989	Liver and kidney microsomal uridine diphosphoglucuronosyltransferase (UDPGT) activity toward all-trans-retinoic acid was increased 3.7- and 2.6-fold, respectively, ten days following exposure to TCDD.	Tretinoin	93-116	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	28-68
2508757-2	1989	Liver and kidney microsomal uridine diphosphoglucuronosyltransferase (UDPGT) activity toward all-trans-retinoic acid was increased 3.7- and 2.6-fold, respectively, ten days following exposure to TCDD.	Tretinoin	93-116	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	70-75
2508757-2	1989	Liver and kidney microsomal uridine diphosphoglucuronosyltransferase (UDPGT) activity toward all-trans-retinoic acid was increased 3.7- and 2.6-fold, respectively, ten days following exposure to TCDD.	Polychlorinated Dibenzodioxins	195-199	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	28-68
2508757-2	1989	Liver and kidney microsomal uridine diphosphoglucuronosyltransferase (UDPGT) activity toward all-trans-retinoic acid was increased 3.7- and 2.6-fold, respectively, ten days following exposure to TCDD.	Polychlorinated Dibenzodioxins	195-199	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	70-75
2491935-2	1989	Bilirubin uridine diphosphoglucuronyl transferase (UDPGT) activity has been demonstrated in normal rat intestinal mucosa.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	10-49
2491935-2	1989	Bilirubin uridine diphosphoglucuronyl transferase (UDPGT) activity has been demonstrated in normal rat intestinal mucosa.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-56
3149508-5	1988	cDNA clones in the vector lambda-gt11 containing sequences for the B1 and B2 chains of laminin were shown to synthesize beta-galactosidase fusion proteins in the host cells induced with IPTG.	Isopropyl Thiogalactoside	186-190	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	67-76
3232340-2	1988	Inclusion into the animals" ration of cutlets enriched with vitamins B1, B2, C and niacin completely normalized their growth and biochemical parameters of their providing with vitamins B1 and B2.	Niacin	83-89	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	185-194
3100574-4	1987	UDPGT isoform V (elution pH 7.5) from Wistar (RHA) rats is active toward bilirubin and 4"-hydroxydimethylaminoazobenzene.	Bilirubin	73-82	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-5
3100574-4	1987	UDPGT isoform V (elution pH 7.5) from Wistar (RHA) rats is active toward bilirubin and 4"-hydroxydimethylaminoazobenzene.	4'-hydroxydimethylaminoazobenzene	87-120	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-5
3100574-5	1987	The corresponding isoform from Gunn rat liver was enzymically inactive but exhibited normal elution pH and mobility on NaDodSO4/polyacrylamide gel electrophoresis (Mr 53,000), and was recognized by a UDPGT-specific antiserum.	polyacrylamide	128-142	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	200-205
3100574-6	1987	UDPGT isoform I (elution pH 8.7) from Wistar (RHA) and Gunn rats was active toward 4-nitrophenol.	4-nitrophenol	83-96	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-5
3100574-7	1987	The isoform from Gunn rat liver had only 10% of normal UDPGT activity, however UDPGT activity increased to normal upon addition of 15 mM diethylnitrosamine in vitro.	Diethylnitrosamine	137-155	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	79-84
3664275-3	1987	When the type B interneurons were further classified into type B1 and type B2 neurons, which were characterized by the occurrence of the STN caudalis-induced inhibition with long and short latencies, respectively, microiontophoretically applied naloxone reduced the STN caudalis-induced inhibition of th orthodromic spikes of type B1 interneurons with little effects on type B2 interneuron.	Naloxone	245-253	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	63-77
3465727-3	1986	Bryostatins 1 and 2 (B1 and B2, respectively) competed for [3H]phorbol 12,13-dibutyrate binding to the protein kinase C complex in intact cells nearly equipotently with TPA.	[3h]phorbol 12,13-dibutyrate	59-87	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-30
3465727-3	1986	Bryostatins 1 and 2 (B1 and B2, respectively) competed for [3H]phorbol 12,13-dibutyrate binding to the protein kinase C complex in intact cells nearly equipotently with TPA.	Tetradecanoylphorbol Acetate	169-172	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-30
3465727-4	1986	B1 and B2, 1-oleoyl-2-acetylglycerol (OAG) and 1,2-dioctanoylglycerol (Di8) as well as TPA each activated partially purified protein kinase C from GH4C5 cells.	1-oleoyl-2-acetylglycerol	38-41	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-9
3465727-7	1986	However, B1 and B2 were only partial agonists because they enhanced prolactin synthesis to a lesser maximal extent than did TPA and, given in combination, they reduced TPA-enhanced prolactin synthesis.	Tetradecanoylphorbol Acetate	168-171	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	9-18
6146523-1	1984	Three cyclic AMP-independent acetyl-CoA carboxylase kinases (A, B1 and B2) have been isolated from lactating rat mammary gland, using phosphocellulose chromatography, high performance gel filtration, and affinity chromatography on casein-Sepharose and phosvitin-Sepharose.	Cyclic AMP	6-16	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	60-74
4015664-7	1985	Uridine-diphospho-glucuronosyl-transferase (UDP-GT) activity in normal and vitamin A deficient groups was enhanced following exposure to benzo(a)pyrene both in lung and liver.	Vitamin A	75-84	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-42
4015664-7	1985	Uridine-diphospho-glucuronosyl-transferase (UDP-GT) activity in normal and vitamin A deficient groups was enhanced following exposure to benzo(a)pyrene both in lung and liver.	Vitamin A	75-84	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	44-50
4015664-7	1985	Uridine-diphospho-glucuronosyl-transferase (UDP-GT) activity in normal and vitamin A deficient groups was enhanced following exposure to benzo(a)pyrene both in lung and liver.	Benzo(a)pyrene	137-151	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-42
4015664-7	1985	Uridine-diphospho-glucuronosyl-transferase (UDP-GT) activity in normal and vitamin A deficient groups was enhanced following exposure to benzo(a)pyrene both in lung and liver.	Benzo(a)pyrene	137-151	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	44-50
6500683-4	1984	Electrical stimulation of the ventrolateral medulla in areas that coincided with the lateral elements of the B1 and B3 serotonin cell groups evoked pressor responses recorded via cannulae in the abdominal aorta.	Serotonin	119-128	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	109-118
6500683-7	1984	Microinjection of methyldopa (4-16 micrograms) directly into the region of the B1 and B3 cells in the ventrolateral medulla evoked a dose-dependent fall in arterial pressure observed for 4 hours.	Methyldopa	18-28	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	79-88
6146523-1	1984	Three cyclic AMP-independent acetyl-CoA carboxylase kinases (A, B1 and B2) have been isolated from lactating rat mammary gland, using phosphocellulose chromatography, high performance gel filtration, and affinity chromatography on casein-Sepharose and phosvitin-Sepharose.	phosphocellulose	134-150	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	60-74
6146523-1	1984	Three cyclic AMP-independent acetyl-CoA carboxylase kinases (A, B1 and B2) have been isolated from lactating rat mammary gland, using phosphocellulose chromatography, high performance gel filtration, and affinity chromatography on casein-Sepharose and phosvitin-Sepharose.	Sepharose	238-247	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	60-74
6146523-1	1984	Three cyclic AMP-independent acetyl-CoA carboxylase kinases (A, B1 and B2) have been isolated from lactating rat mammary gland, using phosphocellulose chromatography, high performance gel filtration, and affinity chromatography on casein-Sepharose and phosvitin-Sepharose.	Sepharose	262-271	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	60-74
6698033-9	1984	SDS gels of IEF fractions and secretion medium indicate Mr 25K, 26K, 27K, 97K, and greater than 150K for A, B1, B2, C, and D respectively.	Sodium Dodecyl Sulfate	0-3	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	105-124
6200721-2	1984	Direct microinjection of methyldopa into the ventrolateral medulla in the area of the B1 and B3 serotonin cells was also effective in lowering arterial pressure.	Methyldopa	25-35	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	86-94
6200721-2	1984	Direct microinjection of methyldopa into the ventrolateral medulla in the area of the B1 and B3 serotonin cells was also effective in lowering arterial pressure.	Serotonin	96-105	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	86-94
6227739-1	1983	The developmental change of the intrinsic clearance (Clint) and the hepatic clearance (ClH) for the glucuronidated p-phenylbenzoic acid (PPBA) by uridine 5"-phosphoglucronic acid-glucuronyltransferase (UDPGT) in liver of rat fetus was investigated.	4-phenylbenzoic acid	137-141	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	146-200
6309378-10	1983	Phenobarbital increased enzyme activities of EH and UDPGT by about 50%.	Phenobarbital	0-13	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	52-57
6361221-3	1983	B1 and B3 are derived from two precursors, P1 (Mr approximately 210,000) and P3 (Mr approximately 185,000) which are nonsialylated, mannose-rich proteins not exposed on the cell surface.	Mannose	132-139	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-9
6227739-1	1983	The developmental change of the intrinsic clearance (Clint) and the hepatic clearance (ClH) for the glucuronidated p-phenylbenzoic acid (PPBA) by uridine 5"-phosphoglucronic acid-glucuronyltransferase (UDPGT) in liver of rat fetus was investigated.	clh	87-90	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	146-200
6227739-1	1983	The developmental change of the intrinsic clearance (Clint) and the hepatic clearance (ClH) for the glucuronidated p-phenylbenzoic acid (PPBA) by uridine 5"-phosphoglucronic acid-glucuronyltransferase (UDPGT) in liver of rat fetus was investigated.	4-phenylbenzoic acid	137-141	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	202-207
6227739-1	1983	The developmental change of the intrinsic clearance (Clint) and the hepatic clearance (ClH) for the glucuronidated p-phenylbenzoic acid (PPBA) by uridine 5"-phosphoglucronic acid-glucuronyltransferase (UDPGT) in liver of rat fetus was investigated.	4-phenylbenzoic acid	115-135	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	146-200
6227739-1	1983	The developmental change of the intrinsic clearance (Clint) and the hepatic clearance (ClH) for the glucuronidated p-phenylbenzoic acid (PPBA) by uridine 5"-phosphoglucronic acid-glucuronyltransferase (UDPGT) in liver of rat fetus was investigated.	4-phenylbenzoic acid	115-135	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	202-207
6179609-1	1982	In preneoplastic rat liver nodules produced by 2-acetylaminofluorene, certain uridine diphosphate-glucuronyltransferase (UDP-GT) activities, which are ascribed to a distinct enzyme form, were selectively increased (5-fold).	2-Acetylaminofluorene	47-68	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	78-119
6179609-1	1982	In preneoplastic rat liver nodules produced by 2-acetylaminofluorene, certain uridine diphosphate-glucuronyltransferase (UDP-GT) activities, which are ascribed to a distinct enzyme form, were selectively increased (5-fold).	2-Acetylaminofluorene	47-68	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	121-127
187331-0	1977	Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo.	aflatoxin B1-2,3-oxide	0-22	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	88-97
187331-0	1977	Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo.	Aflatoxins	77-87	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	88-97
1066329-1	1976	Oxalate metabolism was assessed in normal rats and rats deficient in vitamins B-1 and B-6 during intravenous infusions of solutions containing glucose, fructose, sorbitol or xylitol.	Oxalates	0-7	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	78-89
32393425-0	2020	Effects of cyclosporin A on the pharmacokinetics and toxicities of irinotecan mediated by UGT1A1 in vitro and in vivo.	Cyclosporine	11-24	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	90-96
33054444-8	2021	EGCG inhibited the mRNA and protein expressions of DMEs and DTs, such as CYP3A1, A2, UGT1A1, Mdr1 and Mrp2, but upregulated the expressions of Car, Pxr and Fxr.	epigallocatechin gallate	0-4	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	85-91
32093886-8	2020	Interestingly, in contrast, morphine-3-glucuronide, a major metabolite of morphine was formed, when Ugt2b1 and Ugt1a1 were co-expressed.	morphine-3-glucuronide	28-50	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	111-117
32093886-8	2020	Interestingly, in contrast, morphine-3-glucuronide, a major metabolite of morphine was formed, when Ugt2b1 and Ugt1a1 were co-expressed.	Morphine	28-36	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	111-117
32093886-9	2020	This effect of hetero-oligomerization of Ugt1a1 and Ugt2b1 was also observed for 17beta-estradiol glucuronidation.	Estradiol	81-97	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	41-47
4318833-0	1969	Carcinogenesis in rats by aflatoxins B1, G1, and B2.	Aflatoxins	26-36	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	37-51
33027804-3	2021	The homozygous Gunn rat lacks uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), the enzyme needed to biotransform bilirubin.	Bilirubin	122-131	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	30-77
33027804-3	2021	The homozygous Gunn rat lacks uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), the enzyme needed to biotransform bilirubin.	Bilirubin	122-131	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	79-85
32712531-1	2020	Sorafenib (SR) is one of the most potent UGT (1A1, 1A9) inhibitors (in in vitro tests).	Sorafenib	0-9	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	41-54
32712531-1	2020	Sorafenib (SR) is one of the most potent UGT (1A1, 1A9) inhibitors (in in vitro tests).	Sorafenib	11-13	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	41-54
32961782-4	2020	The HCR also had reduced expression of the glucuronyl hepatic enzyme UGT1A1, which lowers plasma bilirubin.	Bilirubin	97-106	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	69-75
32393425-0	2020	Effects of cyclosporin A on the pharmacokinetics and toxicities of irinotecan mediated by UGT1A1 in vitro and in vivo.	Irinotecan	67-77	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	90-96
32393425-5	2020	However, UDP glucuronyltransferase-1 polypeptide A1 (UGT1A1) was related to a significantly altered disposition of irinotecan and its metabolites, and was therefore associated with irinotecan-induced toxicity.	Irinotecan	115-125	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	9-51
32393425-5	2020	However, UDP glucuronyltransferase-1 polypeptide A1 (UGT1A1) was related to a significantly altered disposition of irinotecan and its metabolites, and was therefore associated with irinotecan-induced toxicity.	Irinotecan	115-125	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	53-59
32393425-5	2020	However, UDP glucuronyltransferase-1 polypeptide A1 (UGT1A1) was related to a significantly altered disposition of irinotecan and its metabolites, and was therefore associated with irinotecan-induced toxicity.	Irinotecan	181-191	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	9-51
32393425-5	2020	However, UDP glucuronyltransferase-1 polypeptide A1 (UGT1A1) was related to a significantly altered disposition of irinotecan and its metabolites, and was therefore associated with irinotecan-induced toxicity.	Irinotecan	181-191	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	53-59
32393425-6	2020	This study focused on UGT1A1-mediated conversion of SN-38 to SN-38G, and systematically investigated the CsA-irinotecan interactions in vitro and in vivo.	Irinotecan	52-57	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	22-28
32393425-6	2020	This study focused on UGT1A1-mediated conversion of SN-38 to SN-38G, and systematically investigated the CsA-irinotecan interactions in vitro and in vivo.	Irinotecan	61-66	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	22-28
32393425-11	2020	The present study indicated that CsA treatment could enhance the systemic exposure and toxicity of SN-38 by inhibiting the UGT1A1 enzyme.	Cyclosporine	33-36	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	123-129
32393425-11	2020	The present study indicated that CsA treatment could enhance the systemic exposure and toxicity of SN-38 by inhibiting the UGT1A1 enzyme.	Irinotecan	99-104	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	123-129
32393425-12	2020	The inhibition of UGT1A1 enzyme might be a critical factor in the failure of CsA improving irinotecan"s treatment index.	Cyclosporine	77-80	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	18-24
32393425-12	2020	The inhibition of UGT1A1 enzyme might be a critical factor in the failure of CsA improving irinotecan"s treatment index.	Irinotecan	91-101	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	18-24
31128210-6	2019	The further enzyme kinetic studies demonstrated that shikonin was not only a competitive inhibitor of human UGT1A1, UGT1A9, and UGT2B7, but also presented competitive inhibition on rat UGT1A1 and AZTG reactions.	shikonin	53-61	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	185-191
31707444-1	2020	PURPOSE: The purpose of this study was to determine the importance of UGT1A1 activity on the metabolism and pharmacokinetics of a releasable PEG ~ SN-38 conjugate, PLX038A.	pentaerythritol poly(ethylene glycol) ether tetrasuccinimidyl glutarate	141-144	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	70-76
31707444-1	2020	PURPOSE: The purpose of this study was to determine the importance of UGT1A1 activity on the metabolism and pharmacokinetics of a releasable PEG ~ SN-38 conjugate, PLX038A.	5-(1H-pyrrolo(2,3-b)pyridin-3-ylmethyl)-N-((4-(trifluoromethyl)phenyl)methyl)pyridin-2-amine	164-171	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	70-76
31707444-2	2020	Irinotecan (CPT-11) is converted to the topoisomerase 1 inhibitor SN-38 by first-pass hepatic metabolism and is converted to its glucuronide SN-38G by UGT1A1.	irinotecan	0-10	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	151-157
31707444-2	2020	Irinotecan (CPT-11) is converted to the topoisomerase 1 inhibitor SN-38 by first-pass hepatic metabolism and is converted to its glucuronide SN-38G by UGT1A1.	irinotecan	12-18	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	151-157
31707444-3	2020	With diminished UGT1A1 activity, the high liver exposure to SN-38 can cause increased toxicity of CPT-11.	irinotecan	98-104	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	16-22
31680983-1	2019	Background: Bilirubin (BR) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) through glucuronidation in the liver.	Bilirubin	12-21	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	52-105
31680983-1	2019	Background: Bilirubin (BR) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) through glucuronidation in the liver.	Bilirubin	12-21	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	107-113
31680983-1	2019	Background: Bilirubin (BR) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) through glucuronidation in the liver.	Bilirubin	23-25	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	52-105
31680983-1	2019	Background: Bilirubin (BR) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) through glucuronidation in the liver.	Bilirubin	23-25	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	107-113
29928229-9	2018	The metabolic effects of puerarin were mediated by Nrf2 through upregulation of UDP-glucuronosyltransferase (UGT) 1A1.	puerarin	25-33	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	80-117
31091465-11	2019	GBHW moderately inhibited the activities of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2E1, CYP3A4, and UGT1A1.	gbhw	0-4	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	97-103
31359665-1	2019	To evaluate the hepatotoxicity risks of physcion on the basis of the bilirubin metabolism mediated by glucuronidation of UDP-glucuronosyltransferases 1A1(UGT1A1 enzyme).	Bilirubin	69-78	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	154-160
31359665-2	2019	The monomers were added into the rat liver microsomes to test the hepatotoxicity by using bilirubin as UGT1A1 enzyme substrate, with apparent inhibition constant K_i as the evaluation index.	Bilirubin	90-99	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	103-109
30280963-1	2018	Gunn rats bear a mutation within the uridine diphosphate glucuronosyltransferase-1a1 (Ugt1a1) gene resulting in high serum bilirubin levels as seen in Crigler-Najjar syndrome.	Bilirubin	123-132	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	37-84
30280963-1	2018	Gunn rats bear a mutation within the uridine diphosphate glucuronosyltransferase-1a1 (Ugt1a1) gene resulting in high serum bilirubin levels as seen in Crigler-Najjar syndrome.	Bilirubin	123-132	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	86-92
29945930-7	2018	The mRNA and protein levels of UGT1A1 and UGT1A9, enzymes for puerarin metabolism, were significantly increased in the liver and heart tissues of AAC rats and Ang II-treated NRCMs.	puerarin	62-70	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	31-37
29945930-8	2018	Interestingly, the silencing of Nrf2 attenuated the puerarin-induced upregulation of UGT1A1 and UGT1A9.	puerarin	52-60	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	85-91
29945930-9	2018	The results of chromatin immunoprecipitation-quantitative polymerase chain reaction indicated that the binding of Nrf2 to the promoter region of Ugt1a1 or Ugt1a9 was significantly enhanced in puerarin-treated cardiomyocytes.	puerarin	192-200	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	145-151
29945930-10	2018	These results suggest that Nrf2 is the key regulator of antihypertrophic effects and upregulation of the metabolic enzymes UGT1A1 and UGT1A9 of puerarin.	puerarin	144-152	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	123-129
29945930-11	2018	The autoregulatory circuits between puerarin and Nrf2-induced UGT1A1/1A9 are beneficial to attenuate adverse effects and maintain the pharmacologic effects of puerarin.	puerarin	36-44	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	62-68
29295636-1	2019	OBJECTIVE: Unconjugated bilirubin (UCB) may cause neurotoxicity in preterm neonates due to immaturity of UGT1A1 leading to bilirubin accumulation in the brain.	Bilirubin	24-33	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	105-111
29295636-1	2019	OBJECTIVE: Unconjugated bilirubin (UCB) may cause neurotoxicity in preterm neonates due to immaturity of UGT1A1 leading to bilirubin accumulation in the brain.	ucb	35-38	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	105-111
29295636-1	2019	OBJECTIVE: Unconjugated bilirubin (UCB) may cause neurotoxicity in preterm neonates due to immaturity of UGT1A1 leading to bilirubin accumulation in the brain.	Bilirubin	123-132	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	105-111
29928229-10	2018	The Nrf2 agonist tBHQ upregulated protein expression of UGT1A1 over time in cardiac fibroblasts.	2-tert-butylhydroquinone	17-21	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	56-62
29928229-11	2018	Treatment with Nrf2 siRNA or brusatol dramatically decreased UGT1A1 expression in puerarin-treated fibroblasts.	brusatol	29-37	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	61-67
29928229-11	2018	Treatment with Nrf2 siRNA or brusatol dramatically decreased UGT1A1 expression in puerarin-treated fibroblasts.	puerarin	82-90	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	61-67
29928229-12	2018	The results of chromatin immunoprecipitation-qPCR further confirmed that puerarin significantly increased binding of Nrf2 to the promoter region of Ugt1a1.	puerarin	73-81	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	148-154
29928229-17	2018	Autoregulatory circuits between puerarin and Nrf2-regulated UGT1A1 attenuates side effects associated with treatment, but it does not weaken puerarin"s pharmacological effects.	puerarin	32-40	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	60-66
29131354-9	2018	An intraperitoneal single administration of 25 mg/kg diazepam (DZP) for the treatment of SE could attenuate heme oxygenase-1 induction in the cortex, whereas Ugt1a1 was decreased in the hippocampus, but not in the cortex, suggesting that there likely exists an alternative mechanism for Ugt1a1 reduction by DZP treatment.	Diazepam	53-61	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	158-164
29311138-3	2018	This study verified the involvement of gut microbiota in intestinal UGT1A1 regulation using dextran sulfate sodium (DSS)-induced rat colitis model plus fecal microbiota transplantation (FMT).	Dextran Sulfate	92-114	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	68-74
29311138-3	2018	This study verified the involvement of gut microbiota in intestinal UGT1A1 regulation using dextran sulfate sodium (DSS)-induced rat colitis model plus fecal microbiota transplantation (FMT).	Dextran Sulfate	116-119	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	68-74
29311138-4	2018	Generally, both DSS induction and colitis-to-normal FMT suppressed mRNA and protein expressions of UGT1A1 and nuclear xenobiotic receptors (NRs) in colon, but enhanced mRNA and decreased protein of rat UGT1A1/rat NRs in small intestine.	Dextran Sulfate	16-19	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	99-105
29311138-4	2018	Generally, both DSS induction and colitis-to-normal FMT suppressed mRNA and protein expressions of UGT1A1 and nuclear xenobiotic receptors (NRs) in colon, but enhanced mRNA and decreased protein of rat UGT1A1/rat NRs in small intestine.	Dextran Sulfate	16-19	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	202-208
29131354-9	2018	An intraperitoneal single administration of 25 mg/kg diazepam (DZP) for the treatment of SE could attenuate heme oxygenase-1 induction in the cortex, whereas Ugt1a1 was decreased in the hippocampus, but not in the cortex, suggesting that there likely exists an alternative mechanism for Ugt1a1 reduction by DZP treatment.	Diazepam	53-61	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	287-293
29131354-9	2018	An intraperitoneal single administration of 25 mg/kg diazepam (DZP) for the treatment of SE could attenuate heme oxygenase-1 induction in the cortex, whereas Ugt1a1 was decreased in the hippocampus, but not in the cortex, suggesting that there likely exists an alternative mechanism for Ugt1a1 reduction by DZP treatment.	Diazepam	63-66	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	287-293
29131354-10	2018	Continuous 14-day administration of DZP inhibited Ugt1a1 induction in the cortex, but did not have an effect on Ugt1a7 induction.	Diazepam	36-39	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	50-56
28065941-8	2017	Additionally, hepatic enzymes, including Ugt1a1, CYP2b1, Sult1e1, and Sult2b1, were significantly induced after DEHP exposure.	Diethylhexyl Phthalate	112-116	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	41-47
28574832-7	2017	The mRNA expression of Ugt1a1 and Nr1i2 were increased 2 and 4 times respectively with dexamethasone (DEX) and 8-Br-cAMP co-treatment in BRL 3A cells.	Dexamethasone	87-100	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	23-29
28574832-7	2017	The mRNA expression of Ugt1a1 and Nr1i2 were increased 2 and 4 times respectively with dexamethasone (DEX) and 8-Br-cAMP co-treatment in BRL 3A cells.	Dexamethasone	102-105	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	23-29
28574832-7	2017	The mRNA expression of Ugt1a1 and Nr1i2 were increased 2 and 4 times respectively with dexamethasone (DEX) and 8-Br-cAMP co-treatment in BRL 3A cells.	8-Bromo Cyclic Adenosine Monophosphate	111-120	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	23-29
28490767-3	2017	Montelukast and Disulfiram were selected as potentially clinically applicable drugs and tested to reduce serum unconjugated bilirubin (UCB) levels in the Ugt1a1-deficient rat, a model for chronic unconjugated hyperbilirubinemia.	montelukast	0-11	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	154-160
28490767-3	2017	Montelukast and Disulfiram were selected as potentially clinically applicable drugs and tested to reduce serum unconjugated bilirubin (UCB) levels in the Ugt1a1-deficient rat, a model for chronic unconjugated hyperbilirubinemia.	Disulfiram	16-26	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	154-160
28490767-4	2017	Oral administration of Disulfiram was toxic in the Ugt1a1-deficient rat (weight loss, transaminase elevation).	Disulfiram	23-33	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-57
28080060-5	2017	The area under the concentration-time curve for polymyxins B1 and B2 was greater than those of colistins A and B. Colistin A (56.6 +- 9.25%) and colistin B (41.7 +- 12.4%) displayed lower plasma protein binding in rat plasma compared to polymyxin B1 (82.3 +- 4.30%) and polymyxin B2 (68.4 +- 3.50%).	Colistin b	145-155	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	59-68
27908259-10	2017	This method was successfully utilized to determine bilirubin glucuronidation kinetics in HLM and human rUGT1A1.	Bilirubin	51-60	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	103-110
28920386-1	2016	To predict the mechanism of liver injury induced by Genkwa Flos, we investigated the effect of chloroform extract on UGTs and UGT1A1 activities of the liver microsomes in rat and human.	Chloroform	95-105	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	126-132
27924530-5	2017	Aflatoxins B1, B2, G1, G2 are the most toxic and carcinogenic mycotoxins, due to their extreme hepatocarcinogenicity; ochratoxin A is a potent nephrotoxin, it is also carcinogenic, teratogenic, and immunotoxic in rats and possibly in humans; fumonisins are hepatotoxic and nephrotoxic with potential carcinogenic effects on rat and mice.	Aflatoxins	0-10	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	11-25
27924530-5	2017	Aflatoxins B1, B2, G1, G2 are the most toxic and carcinogenic mycotoxins, due to their extreme hepatocarcinogenicity; ochratoxin A is a potent nephrotoxin, it is also carcinogenic, teratogenic, and immunotoxic in rats and possibly in humans; fumonisins are hepatotoxic and nephrotoxic with potential carcinogenic effects on rat and mice.	ochratoxin A	118-130	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	11-25
28920386-5	2016	UGT1A1 activity was inhibited by chloroform extract in rat liver microsomes and human liver microsomes (based on genkwanin, IC50=8.76, 10.36 mumol L-1).	Chloroform	33-43	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
27348971-0	2016	Capsaicin induces metabolism of simvasatin in rat: involvement of upregulating expression of Ugt1a1.	Capsaicin	0-9	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	93-99
27149376-8	2016	Real-time quantitative reverse transcriptase-polymerase chain reaction (Q-RT-PCR) analysis revealed a significant increase in mRNA levels for placental steroid metabolism enzymes, including UDP-glucuronosyltransferase 1A1 (UGT1A1), estrogen sulfotransferase 1E1 (SULT1E1), steroid 5alpha-reductase 1 (SRD5A1) and steroid 5alpha-reductase 2 (SRD5A2).	Steroids	152-159	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	190-221
27149376-8	2016	Real-time quantitative reverse transcriptase-polymerase chain reaction (Q-RT-PCR) analysis revealed a significant increase in mRNA levels for placental steroid metabolism enzymes, including UDP-glucuronosyltransferase 1A1 (UGT1A1), estrogen sulfotransferase 1E1 (SULT1E1), steroid 5alpha-reductase 1 (SRD5A1) and steroid 5alpha-reductase 2 (SRD5A2).	Steroids	152-159	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	223-229
27348971-0	2016	Capsaicin induces metabolism of simvasatin in rat: involvement of upregulating expression of Ugt1a1.	simvasatin	32-42	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	93-99
27348971-9	2016	In conclusion, chronic ingestion of CAP enhanced the expression level of Ugt1a1 in liver, causing the food -drug interaction and decrease in SV exposure in rats to a significant extent.	Capsaicin	36-39	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	73-79
26512042-10	2016	The Km and Vmax values describing the formation of the N-glucuronide in HLM or rUGT1A1 were 2.7 microM or 0.75 microM and 8.9 or 8.3 pmol min(-1) mg(-1), respectively.	n-glucuronide	55-68	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	79-86
27002404-11	2016	Multiple UGTs, including UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10, were involved in forming WEL glucuronides and O-methylated WEL glucuronides.	wel glucuronides	111-127	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	25-31
27002404-11	2016	Multiple UGTs, including UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10, were involved in forming WEL glucuronides and O-methylated WEL glucuronides.	wel glucuronides	145-161	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	25-31
25370011-1	2016	In the Crigler-Najjar type I syndrome, the genetic absence of efficient hepatic glucuronidation of unconjugated bilirubin (UCB) by the uridine 5"-diphospho-glucuronosyltransferase1A1 (UGT1A1) enzyme produces the rise of UCB level in blood.	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	135-182
25370011-1	2016	In the Crigler-Najjar type I syndrome, the genetic absence of efficient hepatic glucuronidation of unconjugated bilirubin (UCB) by the uridine 5"-diphospho-glucuronosyltransferase1A1 (UGT1A1) enzyme produces the rise of UCB level in blood.	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	184-190
25370011-1	2016	In the Crigler-Najjar type I syndrome, the genetic absence of efficient hepatic glucuronidation of unconjugated bilirubin (UCB) by the uridine 5"-diphospho-glucuronosyltransferase1A1 (UGT1A1) enzyme produces the rise of UCB level in blood.	ucb	123-126	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	135-182
25370011-1	2016	In the Crigler-Najjar type I syndrome, the genetic absence of efficient hepatic glucuronidation of unconjugated bilirubin (UCB) by the uridine 5"-diphospho-glucuronosyltransferase1A1 (UGT1A1) enzyme produces the rise of UCB level in blood.	ucb	123-126	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	184-190
25370011-1	2016	In the Crigler-Najjar type I syndrome, the genetic absence of efficient hepatic glucuronidation of unconjugated bilirubin (UCB) by the uridine 5"-diphospho-glucuronosyltransferase1A1 (UGT1A1) enzyme produces the rise of UCB level in blood.	ucb	220-223	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	135-182
26104686-4	2015	Different from daphnetin 8-O-glucuronidation exclusively catalyzed by UGT1A6 and UGT1A9, UGT1A1, -1A3, -1A7, -1A8, and -1A9 showed glucuronidation activity toward 7M-DNP.	daphnetin 8-o	15-28	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	89-95
29376311-0	2016	Influence of nanosized amorphous silica on assimilation of vitamins B1, B2 and B6 in rats.	Silicon Dioxide	33-39	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	68-80
29376311-2	2016	The aim of this study was to evaluate the effect of oral administration of SiO2 NPs on assimilation and metabolism of vitamins B1, B2 and B6 in laboratory rats.	Silicon Dioxide	75-79	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	127-140
29376311-12	2016	However, intragastric administration of SiO2 led in animals of groups 7 and 8 to an increase in the urinary excretion of vitamins B1 and B2 and lowering of their content in liver as compared to group 6.	Silicon Dioxide	40-44	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	130-139
29376311-14	2016	Possible reasons are discussed for the adverse lowering impact of SiO2 NPs on the availability of vitamins B1 and B2 and their increased clearance from the body.	Silicon Dioxide	66-70	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	107-116
28861978-0	2016	[In vitro and In vivo effects of six Coptidis alkaloids on liver microsomes UGTs and UGT1A1 activities in rats and mice].	coptidis alkaloids	37-55	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	85-91
28861978-1	2016	In the present study, the effects of six Coptidis alkaloids (berberine, epiberberine, coptisine, jatrorrhizine, palmatine and magnoflorine) on liver microsomes UGTs and UGT1A1 activities in rats and mice were investigated in vitro and in vivo to study the mechanism of metabolic drug-drug interactions of Coptidis Rhizoma with other drugs.	magnoflorine	126-138	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	169-175
26104686-4	2015	Different from daphnetin 8-O-glucuronidation exclusively catalyzed by UGT1A6 and UGT1A9, UGT1A1, -1A3, -1A7, -1A8, and -1A9 showed glucuronidation activity toward 7M-DNP.	7m-dnp	163-169	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	89-95
23572394-7	2015	In conclusion, the findings of the study indicate that TCDD induces a significant oxidative stress in liver microsomes as manifested by increased LPO, H2O2 production, protein carbonyl content and activities of UDPGT and P450 and decreased antioxidant enzymes activities and thiol content.	Polychlorinated Dibenzodioxins	55-59	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	211-216
24555821-15	2014	Reaction phenotyping showed that multiple UGT1A enzymes (including UGT1A1, 1A3, 1A7 and 1A8) are mainly responsible for gossypol metabolism.	Gossypol	120-128	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	67-73
26632182-10	2015	rUGT1A1 had the strongest binding affinity for bilirubin, but the lowest metabolism velocity.	Bilirubin	47-56	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-7
25393417-6	2015	The effects of warfarin on glucuronidation were inhibitory for UGT1A1, 2B7, and 2B17, but activating for UGT1A3.	Warfarin	15-23	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	63-69
23742048-4	2013	METHODS: We used Gunn rat pups, which have a deficiency of the bilirubin-conjugating enzyme UGT1A1.	Bilirubin	63-72	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	92-98
23620377-3	2014	The present study aims to compare the inhibition potential of scutellarin and scutellarein towards several important UDP-glucuronosyltransferase (UGT) isoforms, including UGT1A1, UGT1A6, UGT1A9 and UGT2B7.	scutellarin	62-73	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	171-177
23620377-3	2014	The present study aims to compare the inhibition potential of scutellarin and scutellarein towards several important UDP-glucuronosyltransferase (UGT) isoforms, including UGT1A1, UGT1A6, UGT1A9 and UGT2B7.	scutellarein	78-90	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	171-177
23620377-6	2014	Competitive inhibition of scutellarein towards all these UGT isoforms was demonstrated, and the Ki values were calculated to be 0.02, 5.0, 5.8 and 35.9 muM for UGT1A1, 1A6, 1A9 and 2B7, respectively.	scutellarein	26-38	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	160-166
24056123-9	2013	In line with the up-regulation of UGT1A1 and UGT1A6, urine recovery of VPA glucuronide (VPA-G) was sharply increased by VPA treatment, and the co-treatment of HFD further aggravated this change.	Valproic Acid	71-74	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	34-40
24056123-9	2013	In line with the up-regulation of UGT1A1 and UGT1A6, urine recovery of VPA glucuronide (VPA-G) was sharply increased by VPA treatment, and the co-treatment of HFD further aggravated this change.	Glucuronides	75-86	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	34-40
24056123-9	2013	In line with the up-regulation of UGT1A1 and UGT1A6, urine recovery of VPA glucuronide (VPA-G) was sharply increased by VPA treatment, and the co-treatment of HFD further aggravated this change.	Valproic Acid	88-91	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	34-40
23947957-1	2013	Crigler-Najjar syndrome type I is caused by mutations of the uridine diphospho-glucuronosyl transferase 1A1 (UGT1A1) gene resulting in life-threatening increase of serum bilirubin.	Bilirubin	170-179	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	61-107
23947957-1	2013	Crigler-Najjar syndrome type I is caused by mutations of the uridine diphospho-glucuronosyl transferase 1A1 (UGT1A1) gene resulting in life-threatening increase of serum bilirubin.	Bilirubin	170-179	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	109-115
23932761-8	2013	However, there is good reason to suspect that, at some sufficiently high plasma bilirubin level--as in individuals with very intense Gilbert syndrome or in Gunn rats lacking UGT1A1 activity--the plasma bilirubin pool does indeed provide some antioxidant protection to cells.	Bilirubin	202-211	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	174-180
22981896-0	2012	Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells.	Reactive Oxygen Species	0-23	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	87-106
23328499-8	2013	These findings suggest that tacrolimus inhibits UGT1A1-mediated SN-38 glucuronidation.	Tacrolimus	28-38	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	48-54
23328499-8	2013	These findings suggest that tacrolimus inhibits UGT1A1-mediated SN-38 glucuronidation.	Irinotecan	64-69	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	48-54
23010468-5	2012	Differently, in primary hepatocyte cultures both codeine and heroin inhibited M3G formation, whereas heroin only stimulated de novo synthesis of M6G; moreover, codeine significantly reduced UGT2B1 expression at 6h and caused a trend toward inhibition of UGT1A1 expression at 72h; heroin enhanced UGT2B1 expression and inhibited that of UGT1A1 at 72h; finally, both codeine and heroin depleted UDPGA content of hepatocytes.	Codeine	160-167	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	254-260
22476862-2	2012	This study was designed to estimate the effects of ciprofibrate simultaneously on rat hepatic bilirubin glucuronoconjugation and on hepatic expression of UGT1A1, UGT1A2 and UGT1A5, all of which belong to the bilirubin cluster.	Bilirubin	208-217	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	154-160
22476862-10	2012	A single dose of ciprofibrate significantly induces rat liver bilirubin conjugation as well as UGT1A1, UGT1A5 and PPARalpha expression.	ciprofibrate	17-29	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	95-101
23010468-5	2012	Differently, in primary hepatocyte cultures both codeine and heroin inhibited M3G formation, whereas heroin only stimulated de novo synthesis of M6G; moreover, codeine significantly reduced UGT2B1 expression at 6h and caused a trend toward inhibition of UGT1A1 expression at 72h; heroin enhanced UGT2B1 expression and inhibited that of UGT1A1 at 72h; finally, both codeine and heroin depleted UDPGA content of hepatocytes.	Codeine	160-167	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	336-342
23010468-5	2012	Differently, in primary hepatocyte cultures both codeine and heroin inhibited M3G formation, whereas heroin only stimulated de novo synthesis of M6G; moreover, codeine significantly reduced UGT2B1 expression at 6h and caused a trend toward inhibition of UGT1A1 expression at 72h; heroin enhanced UGT2B1 expression and inhibited that of UGT1A1 at 72h; finally, both codeine and heroin depleted UDPGA content of hepatocytes.	Codeine	160-167	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	254-260
23010468-5	2012	Differently, in primary hepatocyte cultures both codeine and heroin inhibited M3G formation, whereas heroin only stimulated de novo synthesis of M6G; moreover, codeine significantly reduced UGT2B1 expression at 6h and caused a trend toward inhibition of UGT1A1 expression at 72h; heroin enhanced UGT2B1 expression and inhibited that of UGT1A1 at 72h; finally, both codeine and heroin depleted UDPGA content of hepatocytes.	Codeine	160-167	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	336-342
22819525-8	2012	Thickness of media and initial area in aorta of BAPN-treated rats were significantly increased compared with control group (P = 0.001 and P < 0.001, respectively), but no difference in initial area was observed between group B1 and group B2 (P = 0.54).	Aminopropionitrile	48-52	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	228-243
22120979-8	2012	In the few IB4-positive neurons that remained in the L5 DRG, colocalization of GABA(B(1)) -IR decreased to 75%.	ib4	11-14	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	79-89
21040359-6	2012	Hypermethylation of the DYPD gene (encodes the enzyme dihydropyrimidine dehydrogenase) and variation of the uridine diphosphate-glucuronosyltransferase 1A (UGT1A1) gene have predictive value for side effects and the efficacy of 5-fluoruracil and irinotecan, respectively.	Fluorouracil	228-241	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	156-162
21040359-6	2012	Hypermethylation of the DYPD gene (encodes the enzyme dihydropyrimidine dehydrogenase) and variation of the uridine diphosphate-glucuronosyltransferase 1A (UGT1A1) gene have predictive value for side effects and the efficacy of 5-fluoruracil and irinotecan, respectively.	Irinotecan	246-256	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	156-162
21801714-3	2011	Taking CCl(4) induced rat liver dysfunction model, we demonstrated that suppression of UGT1A1 activity in rat liver increased serum bilirubin level which could be reversed by carlinoside (Cln), a flavone glycoside.	carlinoside	175-186	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	87-93
21801714-3	2011	Taking CCl(4) induced rat liver dysfunction model, we demonstrated that suppression of UGT1A1 activity in rat liver increased serum bilirubin level which could be reversed by carlinoside (Cln), a flavone glycoside.	carlinoside	188-191	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	87-93
21801714-3	2011	Taking CCl(4) induced rat liver dysfunction model, we demonstrated that suppression of UGT1A1 activity in rat liver increased serum bilirubin level which could be reversed by carlinoside (Cln), a flavone glycoside.	Cefaclor	7-10	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	87-93
21801714-3	2011	Taking CCl(4) induced rat liver dysfunction model, we demonstrated that suppression of UGT1A1 activity in rat liver increased serum bilirubin level which could be reversed by carlinoside (Cln), a flavone glycoside.	flavone glycoside	196-213	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	87-93
21801714-3	2011	Taking CCl(4) induced rat liver dysfunction model, we demonstrated that suppression of UGT1A1 activity in rat liver increased serum bilirubin level which could be reversed by carlinoside (Cln), a flavone glycoside.	Bilirubin	132-141	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	87-93
21801714-6	2011	This altered V(max) was found to be due to UGT1A1 overexpression by Cln which was observed in both HepG2 and rat primary hepatocytes.	carlinoside	68-71	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	43-49
21543555-9	2011	Microsomal rates of quercetin glucuronidation and UGT expression were positively correlated with UGT1A1 content for all pooled samples (r = 0.467) and at each age (r = 0.538-0.598).	Quercetin	20-29	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	97-103
21855623-9	2011	CONCLUSIONS: The results showed that Fructus evodiae pretreatment decreased the systemic exposure of the Rhizoma coptidis alkaloids by inducing hepatic UGT1A1.	Alkaloids	122-131	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	152-158
21543555-11	2011	Thus, age-related differences in UGT quercetin glucuronidation depend on intestinal segment, are more pronounced in the proximal and distal segments and may be partially related to UGT1A1 and UGT1A7 content.	Quercetin	37-46	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	181-187
21059812-6	2011	CS enhanced UDPGT activities towards 4-nitrophenol (4-NP) (1.9- to 2.0-fold) but did not affect those of bilirubin, testosterone UDPGTs and three STs in both species.	Cesium	0-2	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	12-17
21679931-5	2011	On the other hand, preincubation of astrocytes in the presence of the antioxidant cinnamtannin B-1 (10 muM) also blocked ethanol inhibitory action on glutamate release in response to kainate.	Ethanol	121-128	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	95-98
21679931-5	2011	On the other hand, preincubation of astrocytes in the presence of the antioxidant cinnamtannin B-1 (10 muM) also blocked ethanol inhibitory action on glutamate release in response to kainate.	Glutamic Acid	150-159	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	95-98
21679931-5	2011	On the other hand, preincubation of astrocytes in the presence of the antioxidant cinnamtannin B-1 (10 muM) also blocked ethanol inhibitory action on glutamate release in response to kainate.	Kainic Acid	183-190	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	95-98
21460414-11	2011	Analogously, mRNA expression of conjugative enzyme Ugt1a1 was diminished by fluvastatin administration to cholestatic rats.	Fluvastatin	76-87	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-57
21679931-6	2011	Ethanol (50mM) reduced Ca(2+) mobilization in response to kainate, whereas cinnamtannin B-1 reversed the inhibitory action of ethanol on Ca(2+) mobilization by kainate.	Ethanol	126-133	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	88-91
21420387-8	2011	(ii) CAR-mediated induction of UGT1A1 may be involved in perinatal detoxification of bilirubin neurotoxicity.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	31-37
21059812-6	2011	CS enhanced UDPGT activities towards 4-nitrophenol (4-NP) (1.9- to 2.0-fold) but did not affect those of bilirubin, testosterone UDPGTs and three STs in both species.	4-nitrophenol	37-50	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	12-17
21059812-6	2011	CS enhanced UDPGT activities towards 4-nitrophenol (4-NP) (1.9- to 2.0-fold) but did not affect those of bilirubin, testosterone UDPGTs and three STs in both species.	4-nitrophenol	52-56	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	12-17
19362454-8	2010	The results indicated that saisentong administration increased thyroid weight and thyroid stimulating hormone (TSH) concentrations, and induced hepatic uridine diphosphate glucuronyl transferase (UDPGT) activities in the highest-dose group, although not statistically significant.	saisentong	27-37	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	196-201
21155392-4	2010	BCP N-glucuronidation activities were studied using hepatic microsomes prepared from Wistar rats pretreated with PB (primarily induces UGT1A1, 1A6 and 2B1) or with clofibric acid (CF, primarily induces UGT1A1 and 1A6), and from Gunn rats (deficiency of UGT1A family), and the results were compared with those of untreated rat microsomes.The plasma elimination clearance value of BCP in PB-pretreated rats was approximately 1.4 times greater than that of untreated rats.	Phenobarbital	113-115	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	135-141
21155392-7	2010	The results suggest that UGT 1A1 is primarily responsible for BCP N-glucuronide formation in rats.	bcp	62-65	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	25-32
21155392-7	2010	The results suggest that UGT 1A1 is primarily responsible for BCP N-glucuronide formation in rats.	n-glucuronide	66-79	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	25-32
19362454-8	2010	The results indicated that saisentong administration increased thyroid weight and thyroid stimulating hormone (TSH) concentrations, and induced hepatic uridine diphosphate glucuronyl transferase (UDPGT) activities in the highest-dose group, although not statistically significant.	saisentong	27-37	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	152-194
20531238-8	2010	RESULTS: Dibutyltin dichloride-induced pancreatitis upregulated B1 and B2 mRNA in the thoracic dorsal root ganglion and B2, but not B1, in the pancreas.	Tris(triphenylphosphine)ruthenium(II) chloride	20-30	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	64-73
20546738-10	2010	In contrast, in rats injected with mTTR-UGT1A1.142T, bilirubin levels normalized for up to 6 months and transduced cells were not eliminated.	Bilirubin	53-62	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	40-46
20461738-5	2010	Northern blot analysis revealed diminished expression of liver sulfotransferase (Sult1a1) and uridine-diphosphate glucuronosyltransferase (Ugt1a1) after XN treatment.	xanthohumol	153-155	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	139-145
20008038-9	2010	M1 could be detected in UGT1A1, UGT1A3, and UGT2B7 Supersomes in a CO(2)-rich environment.	Carbon Dioxide	67-72	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	24-30
19375902-8	2010	The results indicated that changes in thyroid endpoints following thiodiazole copper administration decreased serum triiodothyronine (T(3)) and thyroxine (T(4)) concentrations, increased thyroid stimulating hormone (TSH) concentrations and the weight of thyroid gland, induced hepatic uridine diphosphate glucuronyl transferase (UDPGT) activities in the highest dose group and produced thyroid gland hyperplasia.	thiodiazole copper	66-84	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	285-327
19375902-8	2010	The results indicated that changes in thyroid endpoints following thiodiazole copper administration decreased serum triiodothyronine (T(3)) and thyroxine (T(4)) concentrations, increased thyroid stimulating hormone (TSH) concentrations and the weight of thyroid gland, induced hepatic uridine diphosphate glucuronyl transferase (UDPGT) activities in the highest dose group and produced thyroid gland hyperplasia.	thiodiazole copper	66-84	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	329-334
20015472-6	2010	RESULTS: Dietary curcumin enhanced GSHT (p<0.001) and UGT1A1 (p<0.05) activity and significantly reduced the activity of CYP1A1 (p<0.001), in rats exposed to aflatoxin B(1).	Curcumin	17-25	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	57-63
18311190-0	2008	Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors.	Streptozocin	32-46	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	79-83
19077910-6	2009	RESULTS: With B22956/1 (group A), CE increased by 93% in comparison with gadobenate dimeglumine (15.0 +/- 5.3 vs. 7.8 +/- 2.7; P = 0.010) and by 136% in comparison with gadopentetate dimeglumine (15.0 +/- 5.3 vs. 6.4 +/- 1.9; P = 0.013).	Gadolinium DTPA	169-194	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	14-22
18639530-5	2008	The goal of the present study was to investigate the role of UGT1A1 and UGT2B1 in the effects of heroin and naltrexone by determining their influence on the synthesis of E3G and E17G.	Heroin	97-103	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	61-67
18639530-5	2008	The goal of the present study was to investigate the role of UGT1A1 and UGT2B1 in the effects of heroin and naltrexone by determining their influence on the synthesis of E3G and E17G.	Naltrexone	108-118	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	61-67
18582544-8	2008	Trifluralin-induced total hepatic UGT enzymes (2.4-fold) and mRNA expression of selected hepatic UGT isozymes (UGT1A1, 1.4-fold; UGT1A6, 6.4-fold; UGT2B1, 3.7-fold).	Trifluralin	0-11	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	111-117
18639530-13	2008	The present results suggest that heroin and naltrexone can reduce estradiol glucuronidation via a specific interaction with UGT1A1 isoform.	Heroin	33-39	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	124-130
18639530-13	2008	The present results suggest that heroin and naltrexone can reduce estradiol glucuronidation via a specific interaction with UGT1A1 isoform.	Naltrexone	44-54	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	124-130
18515331-3	2008	Treatment of female Sprague-Dawley (SD) rats with 5 mg testosterone propionate/kg/day, 2 ml/kg s.c. for 8 days resulted in induction of renal uridine diphosphoglucuronosyltransferase (UGT) 1A1, as determined by immunoblot and probe substrate activity.	Testosterone Propionate	55-78	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	142-192
18515331-4	2008	Glucuronidation activity for mycophenolic acid, a substrate for rat UGT1A1, 1A6, and 1A7, was significantly elevated approximately 2-fold in renal microsomes from testosterone propionate-treated animals.	Mycophenolic Acid	29-46	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	68-74
18515331-4	2008	Glucuronidation activity for mycophenolic acid, a substrate for rat UGT1A1, 1A6, and 1A7, was significantly elevated approximately 2-fold in renal microsomes from testosterone propionate-treated animals.	Testosterone Propionate	163-186	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	68-74
18311190-5	2008	B(1) receptor mRNA was markedly increased in retinas of diabetic rats, and this was prevented by N-acetyl-L-cysteine (1 g kg(-1) day(-1) for 7 days).	Acetylcysteine	97-116	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-4
18311190-12	2008	CONCLUSIONS AND IMPLICATIONS: Kinin B(1) receptors are upregulated in retinas of STZ-diabetic rats through a mechanism involving oxidative stress.	Streptozocin	81-84	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	36-40
17599282-0	2007	Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture.	Coumarins	30-39	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	43-57
17967931-0	2008	Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet.	Sucrose	237-244	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	22-61
17967931-9	2008	Additionally, administration of the PPARalpha agonist clofibrate to male rats up-regulated UGT1A1 and UGT1A6 and down-regulated CYP1A2 in the liver.	Clofibrate	54-64	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	91-97
17567728-2	2007	After administration, EZE is extensively metabolized in liver and intestine to its phenolic glucuronide form (EZE-G) by uridine diphosphate glucuronosyltransferases (UGTs), among which UGT1A1 and 1A3 exhibit highest activity.	Glucuronides	92-103	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	185-199
17567591-7	2007	UGT isoforms, such as UGT1A1, 1A2, 1A5, 1A6, and 1A7, were expressed, and MRP-1 (multidrug resistance-associated protein) and MRP-3, which are well-known to be transporters of various drug-glucuronides, were detected in the rat uterus by reverse transcription-PCR.	Glucuronides	189-201	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	22-28
18203689-10	2008	The major finding was that MC persistently induced (3- to 10-fold) the expression of several phase II enzymes, including GST-alpha, NQO1, UGT1A1, ALDH, and epoxide hydrolase in both tissues for up to 28 days.	Methylcholanthrene	27-29	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	138-144
17599282-4	2007	In the present study, the effects of the flavone chrysin and six natural coumarins isolated from various Rutaceous plants on UGT1A6-dependent P-nitrophenol and/or UGT1A1-dependent bilirubin glucuronoconjugation activities were evaluated in cultured rat and human hepatocytes and compared to those of the prototypical UGT1A inducers beta-naphthoflavone, phenobarbital and clofibric acid.	Bilirubin	180-189	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	163-169
17599282-4	2007	In the present study, the effects of the flavone chrysin and six natural coumarins isolated from various Rutaceous plants on UGT1A6-dependent P-nitrophenol and/or UGT1A1-dependent bilirubin glucuronoconjugation activities were evaluated in cultured rat and human hepatocytes and compared to those of the prototypical UGT1A inducers beta-naphthoflavone, phenobarbital and clofibric acid.	flavone	41-48	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	163-169
17599282-4	2007	In the present study, the effects of the flavone chrysin and six natural coumarins isolated from various Rutaceous plants on UGT1A6-dependent P-nitrophenol and/or UGT1A1-dependent bilirubin glucuronoconjugation activities were evaluated in cultured rat and human hepatocytes and compared to those of the prototypical UGT1A inducers beta-naphthoflavone, phenobarbital and clofibric acid.	Coumarins	73-82	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	163-169
16581301-8	2006	An AAV1 UGT1A1 vector with the liver-specific albumin promoter corrected serum bilirubin levels but did not induce UGT1A1 antibodies.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	8-14
17439408-14	2007	The results showed that the PCFLS viability remained steady throughout the 6 h of culture when the thickness of slices was 300 microm and pH of the medium was 7.0; CYP inducers (phenobarbital and ethanol) enhanced CYP2E1, CYP3A1/2 and uridine diphosphate-glucuronate transferase (UDPGT) activities, respectively, in a time-dependent manner.	Ethanol	196-203	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	235-278
17439408-14	2007	The results showed that the PCFLS viability remained steady throughout the 6 h of culture when the thickness of slices was 300 microm and pH of the medium was 7.0; CYP inducers (phenobarbital and ethanol) enhanced CYP2E1, CYP3A1/2 and uridine diphosphate-glucuronate transferase (UDPGT) activities, respectively, in a time-dependent manner.	Ethanol	196-203	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	280-285
17292806-4	2007	One of these, xendorphin B1 ((Xen)PDYN-B sequence 96-111: YGGFIRKPDKYKFLNA), is a hexadecapeptide that displaced [3H]naloxone and the radiolabelled kappa opioid, [3H]dynorphin A (1-17), with nanomolar affinity from rat brain membranes.	Tritium	114-116	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	25-27
17292806-4	2007	One of these, xendorphin B1 ((Xen)PDYN-B sequence 96-111: YGGFIRKPDKYKFLNA), is a hexadecapeptide that displaced [3H]naloxone and the radiolabelled kappa opioid, [3H]dynorphin A (1-17), with nanomolar affinity from rat brain membranes.	Naloxone	117-125	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	25-27
17292806-4	2007	One of these, xendorphin B1 ((Xen)PDYN-B sequence 96-111: YGGFIRKPDKYKFLNA), is a hexadecapeptide that displaced [3H]naloxone and the radiolabelled kappa opioid, [3H]dynorphin A (1-17), with nanomolar affinity from rat brain membranes.	Tritium	163-165	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	25-27
16772539-1	2006	Disposition of the lipid-lowering agent ezetimibe (EZ) and its glucuronide (GLUC), which is mainly formed by UDP-glucuronosyltransferase (UGT) 1A1, is influenced by the intestinal efflux transporters P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) 2.	Ezetimibe	40-49	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	109-146
16772539-1	2006	Disposition of the lipid-lowering agent ezetimibe (EZ) and its glucuronide (GLUC), which is mainly formed by UDP-glucuronosyltransferase (UGT) 1A1, is influenced by the intestinal efflux transporters P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) 2.	Glucuronides	63-74	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	109-146
16720684-5	2006	Expressed rat UGT1.1, UGT2B1, and UGT2B12 in HK293 cells catalyzed the N-glucuronidation of FOSA but at rates that were lower than those observed in rat liver microsomes.	Nitrogen	71-72	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	14-20
16720684-8	2006	These data show that rat liver UGT1.1, UGT2B1, and UGT2B12 catalyze the N-glucuronidation of FOSA, albeit at low rates, and that hUGT2B4 and hUGT2B7 catalyze the N-glucuronidation of FOSA.	Nitrogen	72-73	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	31-37
16720684-8	2006	These data show that rat liver UGT1.1, UGT2B1, and UGT2B12 catalyze the N-glucuronidation of FOSA, albeit at low rates, and that hUGT2B4 and hUGT2B7 catalyze the N-glucuronidation of FOSA.	Nitrogen	162-163	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	31-37
21783661-0	2006	Activity of rat UGT1A1 towards benzo[a]pyrene phenols and dihydrodiols.	benzo[a]pyrene phenols	31-53	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	16-22
21783661-0	2006	Activity of rat UGT1A1 towards benzo[a]pyrene phenols and dihydrodiols.	trans-1,2-dihydro-1,2-naphthalenediol	58-70	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	16-22
21783661-2	2006	UGT1A1 and UGT1A7 were found to be broadly active towards BaP metabolites.	benzylaminopurine	58-61	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
21783661-5	2006	Phenobarbital, an inducer of hepatic UGT1A1, only slightly increased BPD UGT activity, whereas UGT1A7 inducers more potently increased the activity.	Phenobarbital	0-13	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	37-43
21783661-6	2006	Inhibition studies using the differential UGT1A1 inhibitor, bilirubin, suggest that UGT1A1 is not a major contributor to the constitutive BPD glucuronidating activity of control rat liver microsomes.	Bilirubin	60-69	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	42-48
16267566-8	2006	UGT1A1 gene transfer was confirmed by the presence of bilirubin glucuronides in bile.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
16267566-8	2006	UGT1A1 gene transfer was confirmed by the presence of bilirubin glucuronides in bile.	Glucuronides	64-76	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
16310220-3	2006	The glucuronidation of bilirubin is catalysed by the microsomal UDP-glucuronosyltransferase UGT1A1.	Bilirubin	23-32	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	92-98
16337205-4	2006	UGT1A1 is involved in the clearance of heme metabolites in the liver.	Heme	39-43	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
15664263-8	2005	HCB increased the activity of hepatic T4 uridine diphosphoglucuronosyl transferase (UDPGT) in a time-dependent manner, without changes in T3 UDPGT.	Hexachlorobenzene	0-3	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	41-82
16203246-6	2005	PB induced hepatic uridine diphosphate-glucuronyltransferase (UDPGT) activity almost 2-fold, whereas PTU reduced hepatic 5 -deiodinase I (5 -DI) activity to < 10% of control in support of previous reports regarding the mechanism of action of each chemical.	Phenobarbital	0-2	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	19-60
16203246-6	2005	PB induced hepatic uridine diphosphate-glucuronyltransferase (UDPGT) activity almost 2-fold, whereas PTU reduced hepatic 5 -deiodinase I (5 -DI) activity to < 10% of control in support of previous reports regarding the mechanism of action of each chemical.	Phenobarbital	0-2	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	62-67
16203246-7	2005	NaI also significantly altered liver weights and UDPGT activity but did not affect thyroid hormone levels or thyroid pathology.	Sodium Iodide	0-3	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	49-54
15973133-5	2005	RESULTS: Dynamic contrast-enhanced magnetic resonance imaging data showed that tamoxifen treatment decreased vascular permeability to B22956/1, whereas no difference was detectable in permeability to gadoteridol or to (Gd-DTPA)37-albumin.	Tamoxifen	79-88	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	134-142
15973133-7	2005	CONCLUSIONS: B22956/1 is superior to both small Gd chelates and macromolecular contrast agents in the assessment of the effect of tamoxifen treatment on tumor vasculature.	Tamoxifen	130-139	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	13-21
17178690-10	2006	Uridine diphopho-glucuronosyl transferase (UDPGT), the T4 metabolizing enzyme measured as glucuronidation of 1-naphthol, was induced to the same extent after 30 and 90 days for all three conazoles.	1-naphthol	109-119	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-41
17178690-10	2006	Uridine diphopho-glucuronosyl transferase (UDPGT), the T4 metabolizing enzyme measured as glucuronidation of 1-naphthol, was induced to the same extent after 30 and 90 days for all three conazoles.	1-naphthol	109-119	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	43-48
17178690-10	2006	Uridine diphopho-glucuronosyl transferase (UDPGT), the T4 metabolizing enzyme measured as glucuronidation of 1-naphthol, was induced to the same extent after 30 and 90 days for all three conazoles.	conazoles	187-196	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-41
17178690-10	2006	Uridine diphopho-glucuronosyl transferase (UDPGT), the T4 metabolizing enzyme measured as glucuronidation of 1-naphthol, was induced to the same extent after 30 and 90 days for all three conazoles.	conazoles	187-196	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	43-48
16006569-9	2005	The organ tissues had strong glucuronidation activities toward the OH-PCBs tested; and most OH-PCBs were glucuronidated by UGT1A1, UGT1A6, and UGT2B1, all of which were substrate-specific.	oh-pcbs	92-99	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	123-129
16006569-10	2005	In conclusion, glucuronidation activities of UGT1A1, UGT1A6, and UGT2B1 toward OH-PCBs is relative to expression of the isoforms in each tissue, and glucuronidation intensity of the isoforms is relative to the structure of the OH-PCB to be glucuronidated.	oh-pcbs	79-86	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	45-51
16006569-10	2005	In conclusion, glucuronidation activities of UGT1A1, UGT1A6, and UGT2B1 toward OH-PCBs is relative to expression of the isoforms in each tissue, and glucuronidation intensity of the isoforms is relative to the structure of the OH-PCB to be glucuronidated.	oh-pcb	79-85	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	45-51
15673846-7	2005	A single dose of DMP 904 (200 mg/kg) increased mRNA levels of hepatic cytochrome P450s (CYP 3A1 and CYP 2B1) and UDP-glucuronosyltransferases (UGT 1A1 and UGT 1A2).	4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine	17-24	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	143-150
15664263-8	2005	HCB increased the activity of hepatic T4 uridine diphosphoglucuronosyl transferase (UDPGT) in a time-dependent manner, without changes in T3 UDPGT.	Hexachlorobenzene	0-3	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	84-89
15254343-1	2004	We have previously demonstrated that in mice, the decrease in serum thyroxine (T(4)) level by polychlorinated biphenyls (PCBs) occurs without an increase in the UDP-glucuronosyltransferase (T(4)-UDP-GT) for T(4) glucuronidation, although the PCB-induced decrease in rats is generally thought to occur through induction of T(4)-UDP-GT, UGT1A1, and UGT1A6.	Polychlorinated Biphenyls	121-125	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	335-341
15135348-2	2004	Bilirubin UDP-glucuronosyltransferase (UGT1A1), which plays a critical role in bilirubin glucuronidation, has been reported to be deficient in CNS type 1.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	39-45
15147298-2	2004	In this regard, here we demonstrate for the first time that GABA(B) receptor isoforms [i.e. GABA(B(1)) and GABA(B(2))] are specifically localized in the rat Schwann cell population of the sciatic nerve.	gamma-Aminobutyric Acid	60-64	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	92-102
15135348-16	2004	Deficient UGT1A1 activity-associated retention of unconjugated bilirubin in the hepatocytes may modulate the expressions of these transporters in Gunn rats.	Bilirubin	63-72	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	10-16
15047030-2	2004	The biological actions of these polypeptides binding on their receptors (B1 and B2) have been related to inflammation process, cytokines action, glutamate release and prostaglandins production.	Glutamic Acid	145-154	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	73-83
15102944-4	2004	Transcriptional profiling in liver and small intestine revealed that L-742694 and dexamethasone (DEX) induced the prototypical battery of PXR target genes in liver, including CYP3A, Oatp2, and UGT1A1.	L 742694	69-77	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	193-199
15102944-4	2004	Transcriptional profiling in liver and small intestine revealed that L-742694 and dexamethasone (DEX) induced the prototypical battery of PXR target genes in liver, including CYP3A, Oatp2, and UGT1A1.	Dexamethasone	82-95	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	193-199
15102944-4	2004	Transcriptional profiling in liver and small intestine revealed that L-742694 and dexamethasone (DEX) induced the prototypical battery of PXR target genes in liver, including CYP3A, Oatp2, and UGT1A1.	Dexamethasone	97-100	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	193-199
15047030-2	2004	The biological actions of these polypeptides binding on their receptors (B1 and B2) have been related to inflammation process, cytokines action, glutamate release and prostaglandins production.	Prostaglandins	167-181	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	73-83
15081544-1	2004	The variable fragment (Fv) of the monoclonal B1-8 antibody recognizes 3-nitro-4-hydroxy-phenylacetate (NP) and 5-iodo-NP (NIP) allowing for the affinity purification of the respective B cell antigen receptor with NP-sepharose and its specific elution with NIP-capronic acid (NIPcap).	3-nitro-4-hydroxy-phenylacetate	70-101	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	45-49
15081544-1	2004	The variable fragment (Fv) of the monoclonal B1-8 antibody recognizes 3-nitro-4-hydroxy-phenylacetate (NP) and 5-iodo-NP (NIP) allowing for the affinity purification of the respective B cell antigen receptor with NP-sepharose and its specific elution with NIP-capronic acid (NIPcap).	Neptunium	103-105	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	45-49
15081544-1	2004	The variable fragment (Fv) of the monoclonal B1-8 antibody recognizes 3-nitro-4-hydroxy-phenylacetate (NP) and 5-iodo-NP (NIP) allowing for the affinity purification of the respective B cell antigen receptor with NP-sepharose and its specific elution with NIP-capronic acid (NIPcap).	N-(4-isothiocyanatophenethyl)spiperone	122-125	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	45-49
15081544-1	2004	The variable fragment (Fv) of the monoclonal B1-8 antibody recognizes 3-nitro-4-hydroxy-phenylacetate (NP) and 5-iodo-NP (NIP) allowing for the affinity purification of the respective B cell antigen receptor with NP-sepharose and its specific elution with NIP-capronic acid (NIPcap).	Sepharose	216-225	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	45-49
15081544-1	2004	The variable fragment (Fv) of the monoclonal B1-8 antibody recognizes 3-nitro-4-hydroxy-phenylacetate (NP) and 5-iodo-NP (NIP) allowing for the affinity purification of the respective B cell antigen receptor with NP-sepharose and its specific elution with NIP-capronic acid (NIPcap).	nip-capronic acid	256-273	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	45-49
15081544-1	2004	The variable fragment (Fv) of the monoclonal B1-8 antibody recognizes 3-nitro-4-hydroxy-phenylacetate (NP) and 5-iodo-NP (NIP) allowing for the affinity purification of the respective B cell antigen receptor with NP-sepharose and its specific elution with NIP-capronic acid (NIPcap).	nipcap	275-281	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	45-49
12871832-11	2003	Pretreatment with indomethacin (5 mg kg(-1)) or atenolol (1 mg kg(-1)) reduced the OVA-induced hypersensitivity at 1 and 3 h, but not at 5 h after challenge, while the combination of B(1) and B(2) bradykinin receptor antagonists was ineffective over the same times.	Indomethacin	18-30	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	183-216
14529832-1	2003	Bilirubin is glucuronidated by bilirubin UDP-glucuronyltransferase (UGT1A1) before biliary excretion.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	68-74
14529832-11	2003	Injection of a lentiviral UGT1A1 vector into third-trimester Gunn rat fetuses corrects the metabolic deficiency and mediates a reduction of serum bilirubin levels that would be therapeutic in humans.	Bilirubin	146-155	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	26-32
14620509-4	2003	Variations in the expression levels of four different UGT isoforms (UGT1A1, 1A2, 1A5, and 1A6) that are involved in the glucuronication of bilirubin and phenols were determined by comparison with those of an internal standard, beta-actin, which is known to be insensitive to nutritional and hormonal conditions.	Bilirubin	139-148	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	68-74
12818378-7	2003	Western blot analysis revealed increased levels of UGT1A1 and 1A5 (bilirubin and 3-OH ethynylestradiol conjugation), and 2B1 (17 beta-OH ethynylestradiol conjugation).	Bilirubin	67-76	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-65
12818378-7	2003	Western blot analysis revealed increased levels of UGT1A1 and 1A5 (bilirubin and 3-OH ethynylestradiol conjugation), and 2B1 (17 beta-OH ethynylestradiol conjugation).	3-oh ethynylestradiol	81-102	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-65
12871832-11	2003	Pretreatment with indomethacin (5 mg kg(-1)) or atenolol (1 mg kg(-1)) reduced the OVA-induced hypersensitivity at 1 and 3 h, but not at 5 h after challenge, while the combination of B(1) and B(2) bradykinin receptor antagonists was ineffective over the same times.	Atenolol	48-56	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	183-216
12101428-12	2002	In contrast, after Ad-hUGT1A1 (which expresses UGT1A1 alone) injection, serum bilirubin remained normal for only 4 weeks, and returned to preinjection levels by day 120.	Bilirubin	78-87	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	23-29
14640891-10	2003	Among the four endothelin antagonists tested in continuous infusion only the non-selective PD145065 and ET(B1/B2) selective BQ788 (in molar concentrations) slightly reduced the early contractile dysfunction of the heart induced by ischemia, whereas ET(A)-selective PD155080 partially protected the rat heart on reperfusion.	BQ 788	124-129	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	104-112
12220528-2	2002	A premature termination codon is predicted to produce truncated UGT1 proteins that lack the COOH-terminal 116 amino acids in Gunn rat.	Carbonic Acid	92-96	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	64-68
12220528-4	2002	However, the truncated UGT1A1 protein was degraded rapidly with a half-life of about 50 min, whereas the wild-type UGT1A1 protein had a much longer half-life of about 10 h. The rapid degradation of truncated UGT1A1 protein was inhibited partially but not completely by treating Gunn rat hepatocytes with proteasome inhibitors such as carbobenzoxy-Leu-Leu-leucinal and lactacystin.	lactacystin	368-379	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	23-29
12220528-4	2002	However, the truncated UGT1A1 protein was degraded rapidly with a half-life of about 50 min, whereas the wild-type UGT1A1 protein had a much longer half-life of about 10 h. The rapid degradation of truncated UGT1A1 protein was inhibited partially but not completely by treating Gunn rat hepatocytes with proteasome inhibitors such as carbobenzoxy-Leu-Leu-leucinal and lactacystin.	lactacystin	368-379	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	115-121
12220528-4	2002	However, the truncated UGT1A1 protein was degraded rapidly with a half-life of about 50 min, whereas the wild-type UGT1A1 protein had a much longer half-life of about 10 h. The rapid degradation of truncated UGT1A1 protein was inhibited partially but not completely by treating Gunn rat hepatocytes with proteasome inhibitors such as carbobenzoxy-Leu-Leu-leucinal and lactacystin.	lactacystin	368-379	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	115-121
12220528-6	2002	Our findings show that the absence of UGT1 protein from Gunn rat hepatocytes is due to rapid degradation of the truncated UGT1 protein by the proteasome and elucidate the molecular basis underlying the deficiency in bilirubin glucuronidation.	Bilirubin	216-225	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	38-42
12595889-4	2003	Progressive repopulation of the liver by engrafted UGT1A1-proficient hepatocytes over 5 months was demonstrated by the appearance of UGT1A1 protein and enzyme activity in the liver, biliary bilirubin glucuronides secretion, and long-term normalization of serum bilirubin levels.	Bilirubin	190-199	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-57
12595889-4	2003	Progressive repopulation of the liver by engrafted UGT1A1-proficient hepatocytes over 5 months was demonstrated by the appearance of UGT1A1 protein and enzyme activity in the liver, biliary bilirubin glucuronides secretion, and long-term normalization of serum bilirubin levels.	Glucuronides	200-212	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-57
12595889-4	2003	Progressive repopulation of the liver by engrafted UGT1A1-proficient hepatocytes over 5 months was demonstrated by the appearance of UGT1A1 protein and enzyme activity in the liver, biliary bilirubin glucuronides secretion, and long-term normalization of serum bilirubin levels.	Bilirubin	261-270	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-57
12185559-2	2002	Studies in rats have indicated that UGT1A1 may also contribute to the formation of morphine 3-glucuronide (M3G).	morphine-3-glucuronide	83-105	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	36-42
11793422-0	2002	Repeated cocaine administration increases GABA(B(1)) subunit mRNA in rat brain.	Cocaine	9-16	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	42-52
12054569-1	2002	The molecular mechanisms of the hepatic transport of B22956/1, a new gadolinium complex from the class of intravascular contrast agents for MRI, which undergoes extensive biliary elimination, were studied.	Gadolinium	69-79	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	53-61
12054569-5	2002	In vitro, the cellular accumulation of B22956/1 was significantly lower in both MRP1 and MRP2 transfected cells as compared to wild type MDCKII cells, and the cellular efflux was prevented by the MRP inhibitor MK571, indicating the involvement of both MRP2 and MRP1 in the transport of B22956/1.	verlukast	210-215	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	39-47
12054569-5	2002	In vitro, the cellular accumulation of B22956/1 was significantly lower in both MRP1 and MRP2 transfected cells as compared to wild type MDCKII cells, and the cellular efflux was prevented by the MRP inhibitor MK571, indicating the involvement of both MRP2 and MRP1 in the transport of B22956/1.	verlukast	210-215	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	286-294
11854140-11	2002	These findings suggest that PCN enhances T(4) UGT activity by increased expression of UGT1A1 and that 3-MC and PCB enhance T(4) UGT activity by increased expression of UGT1A6.	Pregnenolone Carbonitrile	28-31	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	86-92
12153725-5	2002	The mRNA of UGT1A1, which is an isoform contributing to the glucuronidation of bilirubin, increased significantly in the liver and slightly in the kidney after hypophysectomy.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	12-18
11793422-4	2002	A significant increase in the level of GABA(B(1)) mRNA was observed in the nucleus accumbens (11.4%), CA1 field of the hippocampus (16.8%), and thalamus (16.5%) 1 day after repeated administrations of cocaine for 14 consecutive days.	Cocaine	201-208	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	39-49
11602247-0	2001	Biliary excretion of a stretched bilirubin in UGT1A1-deficient (Gunn) and Mrp2-deficient (TR-) rats.	Bilirubin	33-42	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	46-52
11848303-3	2002	In the present work, the participation of Kupffer cells in the ethanol dependent induction of UGT1A1 was investigated.	Ethanol	63-70	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	94-100
11848303-5	2002	We compared the effect of chronic ethanol ingestion on UGT1A1 expression in the liver of normal and gadolinium chloride treated rats.	Ethanol	34-41	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	55-61
11848303-5	2002	We compared the effect of chronic ethanol ingestion on UGT1A1 expression in the liver of normal and gadolinium chloride treated rats.	gadolinium chloride	100-119	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	55-61
11829457-1	2002	UDP-glucuronosyltransferase (UGT1A1) is a critical enzyme in the elimination of bilirubin.	Bilirubin	80-89	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	29-35
11829457-4	2002	Marked induction was detected in the cases of dexamethasone, clofibrate, and rifampicin treatments for 96 h both in enzyme activity (178, 176, and 168%) and in UGT1A1 protein level (362, 328, and 250%).	Dexamethasone	46-59	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	160-166
11829457-4	2002	Marked induction was detected in the cases of dexamethasone, clofibrate, and rifampicin treatments for 96 h both in enzyme activity (178, 176, and 168%) and in UGT1A1 protein level (362, 328, and 250%).	Clofibrate	61-71	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	160-166
11829457-4	2002	Marked induction was detected in the cases of dexamethasone, clofibrate, and rifampicin treatments for 96 h both in enzyme activity (178, 176, and 168%) and in UGT1A1 protein level (362, 328, and 250%).	Rifampin	77-87	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	160-166
11848303-1	2002	Recently we have reported that bilirubin UDP-glucuronosyltransferase (UGT1A1) is induced in rat liver by chronic ethanol treatment.	Ethanol	113-120	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	70-76
11803431-3	2001	Because the liver architecture is not disturbed in CN-1 and partial correction of bilirubin-UDP-glucuronosyltransferase (UGT1A1) activity is expected to be sufficient for protection against kernicterus, cell and gene therapies are being developed using the Gunn rat as an animal model of the disease.	Bilirubin	82-91	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	121-127
11412396-3	2001	RESULTS: Following treatment with alcohol in rats, UGT1A1 mRNA and UGT1A5 mRNA were increased to a mean of 177% and 166% of control, respectively.	Alcohols	34-41	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-57
11412396-5	2001	Incubation of hepatocytes with ethanol and isopentanol significantly increased the mRNA expression of UGT1A1, UGT1A5, UGT2B1 and UGT2B3 mRNA.	Ethanol	31-38	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	102-108
11412396-5	2001	Incubation of hepatocytes with ethanol and isopentanol significantly increased the mRNA expression of UGT1A1, UGT1A5, UGT2B1 and UGT2B3 mRNA.	isopentyl alcohol	43-54	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	102-108
11299074-0	2001	Influence of vitamin A status on the regulation of uridine (5"-)diphosphate-glucuronosyltransferase (UGT) 1A1 and UGT1A6 expression by L-triiodothyronine.	Vitamin A	13-22	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-109
11299074-0	2001	Influence of vitamin A status on the regulation of uridine (5"-)diphosphate-glucuronosyltransferase (UGT) 1A1 and UGT1A6 expression by L-triiodothyronine.	Triiodothyronine	135-153	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-109
11299074-2	2001	They are responsible for glucuronidation of many substrates, especially including bilirubin (UGT1A1) and phenolic compounds (UGT1A6).	Bilirubin	82-91	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	93-99
11299074-8	2001	In addition we observed that the specific effect of l-T3 on UGT1A1 and UGT1A6 was reduced in animals receiving a vitamin A-enriched diet and disappeared in those fed a vitamin A-free diet.	Triiodothyronine	52-56	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	60-66
11299074-8	2001	In addition we observed that the specific effect of l-T3 on UGT1A1 and UGT1A6 was reduced in animals receiving a vitamin A-enriched diet and disappeared in those fed a vitamin A-free diet.	Vitamin A	113-122	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	60-66
11299074-8	2001	In addition we observed that the specific effect of l-T3 on UGT1A1 and UGT1A6 was reduced in animals receiving a vitamin A-enriched diet and disappeared in those fed a vitamin A-free diet.	Vitamin A	168-177	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	60-66
11091029-1	2000	Several drug-metabolizing enzymes including bilirubin UDP-glucuronosyltransferase (UGT1A1) are influenced by long-term ethanol consumption.	Ethanol	119-126	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	83-89
10950843-6	2000	With the exception of one UGT isozyme (UGT1A1), the elevations in mRNA were blocked by prior administration of actinomycin D, indicative of a transcription-dependent response.	Dactinomycin	111-124	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	39-45
11022826-3	2000	METHODS AND RESULTS: Incubation of hepatocytes with bilirubin (48 micromol/L) for 24 h significantly increased the mRNA expression of UGT1A1 and UGT1A5, two UGT isoforms responsible for the conjugation of bilirubin.	Bilirubin	52-61	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	134-140
11022826-3	2000	METHODS AND RESULTS: Incubation of hepatocytes with bilirubin (48 micromol/L) for 24 h significantly increased the mRNA expression of UGT1A1 and UGT1A5, two UGT isoforms responsible for the conjugation of bilirubin.	Bilirubin	205-214	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	134-140
11022826-4	2000	The induction of UGT1A1 and UGT1A5 by bilirubin was concentration and time dependent.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	17-23
11091029-2	2000	In the present study, the activity and expression of UGT1A1 were investigated in livers of ethanol-treated rats.	Ethanol	91-98	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	53-59
11091029-6	2000	The elevation of UGT1A1 mRNA was observed in the liver of ethanol consumer animals with the simultaneous increase in microsomal UGT1A1 protein leading to stimulated bilirubin glucuronidation both in vivo and in microsomal vesicles.	Ethanol	58-65	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	17-23
11091029-6	2000	The elevation of UGT1A1 mRNA was observed in the liver of ethanol consumer animals with the simultaneous increase in microsomal UGT1A1 protein leading to stimulated bilirubin glucuronidation both in vivo and in microsomal vesicles.	Bilirubin	165-174	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	17-23
11091029-6	2000	The elevation of UGT1A1 mRNA was observed in the liver of ethanol consumer animals with the simultaneous increase in microsomal UGT1A1 protein leading to stimulated bilirubin glucuronidation both in vivo and in microsomal vesicles.	Bilirubin	165-174	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	128-134
10845702-16	2000	Effects of 3-MC on UGT1A1 expression revealed downregulation in the liver and highly variable effects in duodenum and stomach.	Methylcholanthrene	11-15	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	19-25
10854630-1	2000	Aflatoxin B1(AFB1)-glutathione(GSH) conjugation is the major pathway for the detoxification of aflatoxin metabolites.	Glutathione	19-30	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	10-17
10854630-1	2000	Aflatoxin B1(AFB1)-glutathione(GSH) conjugation is the major pathway for the detoxification of aflatoxin metabolites.	Glutathione	31-34	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	10-17
10854630-1	2000	Aflatoxin B1(AFB1)-glutathione(GSH) conjugation is the major pathway for the detoxification of aflatoxin metabolites.	Aflatoxins	95-104	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	10-17
10845190-6	2000	Drastic increase in TSH level was observed in the PTU-treated group together with significant decreases in serum thyroid hormone levels and an increase in hepatic UDPGT activity.	Propylthiouracil	50-53	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	163-168
10845190-9	2000	These results indicate that the effect of SF is similar to those of PB and thyroid hypertrophy seen in the oral 2-week treatment with SF, and may be caused by indirectly elevated TSH levels which resulted from the induction of hepatic UDPGT activity.	sesamodil	42-44	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	235-240
10845190-9	2000	These results indicate that the effect of SF is similar to those of PB and thyroid hypertrophy seen in the oral 2-week treatment with SF, and may be caused by indirectly elevated TSH levels which resulted from the induction of hepatic UDPGT activity.	Thyrotropin	179-182	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	235-240
10468611-3	1999	The Gunn rat is an excellent animal model of this disease, exhibiting a single guanosine (G) base deletion within the UGT1A1 gene.	Guanosine	79-88	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	118-124
10699571-7	2000	The results from the present study indicate that increase in the hepatic T(4) glucuronidation after the administration of the seven 3-MeSO(2)-PCBs and 4-MeSO(2)-CB101 possibly because of the induction of both UGT1A1 and UGT1A6 caused the reduction of serum T(4) levels.	3-meso(2)-pcbs	132-146	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	209-215
10699571-7	2000	The results from the present study indicate that increase in the hepatic T(4) glucuronidation after the administration of the seven 3-MeSO(2)-PCBs and 4-MeSO(2)-CB101 possibly because of the induction of both UGT1A1 and UGT1A6 caused the reduction of serum T(4) levels.	4-meso(2)-cb101	151-166	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	209-215
10794513-4	2000	Chronic ethanol feeding of rats significantly increased the expression of liver UGT1A1 mRNA to 177% of control.	Ethanol	8-15	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	80-86
10794513-6	2000	In cultured hepatocytes, treatment with either ethanol or isopentanol significantly increased the expression of UGT1A1, UGT1A5, UGT2B1, and UGT2B3 mRNAs, but to different degrees.	Ethanol	47-54	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	112-118
10794513-6	2000	In cultured hepatocytes, treatment with either ethanol or isopentanol significantly increased the expression of UGT1A1, UGT1A5, UGT2B1, and UGT2B3 mRNAs, but to different degrees.	isopentyl alcohol	58-69	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	112-118
10794513-7	2000	The induction of UGT1A1 and UGT2B1 mRNAs by ethanol or isopentanol was time-dependent and maximal changes occurred at 48 h. The expression of UGT1A6 mRNA was not significantly modified by either ethanol or isopentanol.	Ethanol	44-51	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	17-23
10794513-7	2000	The induction of UGT1A1 and UGT2B1 mRNAs by ethanol or isopentanol was time-dependent and maximal changes occurred at 48 h. The expression of UGT1A6 mRNA was not significantly modified by either ethanol or isopentanol.	isopentyl alcohol	55-66	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	17-23
10468611-5	1999	Here, we show permanent correction of the UGT1A1 genetic defect in Gunn rat liver with site-specific replacement of the absent G residue at nucleotide 1206 by using an RNA/DNA oligonucleotide designed to promote endogenous repair of genomic DNA.	Oligonucleotides	176-191	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	42-48
10468611-9	1999	Our results indicate that correction of the UGT1A1 genetic lesion in the Gunn rat restores enzyme expression and bilirubin conjugating activity, with consequent improvement in the metabolic abnormality.	Bilirubin	113-122	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	44-50
10611137-9	2000	Western blot analysis revealed that only the amount of UGT1A1 was elevated by Cl and DEX.	Dexamethasone	85-88	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	55-61
10611137-11	2000	Previous studies demonstrated that UGT1A1 inducers like phenobarbital have no effect on T4 conjugation ().	Phenobarbital	56-69	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	35-41
10220490-5	1999	In the rat, 90% of retigabine N-glucuronidation is catalyzed by UDP-glucuronosyltransferase (UGT)1A1 and UGT1A2, whereas family 2 UGT enzymes contribute also.	retigabine n	19-31	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	93-100
9202038-3	1997	Following 3,5, 3"-triiodo-L-thyronine (T3) stimulation in vivo, there is a gradual increase in the amount of UGT1A1 mRNA with maximum levels reached 24 h after treatment.	Triiodothyronine	10-37	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	109-115
10100302-8	1999	The regulation of UGT1A1 and UGT2B1 by dexamethasone was dose and time dependent, and the induction of dexamethasone in the expression of UGT1A1 and UGT2B1 was blocked by cycloheximide but not dichloro-1-D-ribofuranosylbenzimidazole.	Dexamethasone	39-52	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	18-24
10100302-8	1999	The regulation of UGT1A1 and UGT2B1 by dexamethasone was dose and time dependent, and the induction of dexamethasone in the expression of UGT1A1 and UGT2B1 was blocked by cycloheximide but not dichloro-1-D-ribofuranosylbenzimidazole.	Dexamethasone	103-116	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	18-24
10100302-8	1999	The regulation of UGT1A1 and UGT2B1 by dexamethasone was dose and time dependent, and the induction of dexamethasone in the expression of UGT1A1 and UGT2B1 was blocked by cycloheximide but not dichloro-1-D-ribofuranosylbenzimidazole.	Dexamethasone	103-116	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	138-144
10100302-8	1999	The regulation of UGT1A1 and UGT2B1 by dexamethasone was dose and time dependent, and the induction of dexamethasone in the expression of UGT1A1 and UGT2B1 was blocked by cycloheximide but not dichloro-1-D-ribofuranosylbenzimidazole.	Cycloheximide	171-184	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	18-24
10100302-8	1999	The regulation of UGT1A1 and UGT2B1 by dexamethasone was dose and time dependent, and the induction of dexamethasone in the expression of UGT1A1 and UGT2B1 was blocked by cycloheximide but not dichloro-1-D-ribofuranosylbenzimidazole.	Cycloheximide	171-184	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	138-144
10100302-8	1999	The regulation of UGT1A1 and UGT2B1 by dexamethasone was dose and time dependent, and the induction of dexamethasone in the expression of UGT1A1 and UGT2B1 was blocked by cycloheximide but not dichloro-1-D-ribofuranosylbenzimidazole.	dichloro-1-d-ribofuranosylbenzimidazole	193-232	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	18-24
10100302-8	1999	The regulation of UGT1A1 and UGT2B1 by dexamethasone was dose and time dependent, and the induction of dexamethasone in the expression of UGT1A1 and UGT2B1 was blocked by cycloheximide but not dichloro-1-D-ribofuranosylbenzimidazole.	dichloro-1-d-ribofuranosylbenzimidazole	193-232	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	138-144
10198767-1	1999	A certain decrease in the content of riboflavin in blood plasma and liver and its excretion in the urine were encountered 24-h after administration of phthalazol, according to the schedule of acute dysentery treatment, in rats with initial moderate deficiency in vitamins B1 and B2.	Riboflavin	37-47	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	272-281
10198767-1	1999	A certain decrease in the content of riboflavin in blood plasma and liver and its excretion in the urine were encountered 24-h after administration of phthalazol, according to the schedule of acute dysentery treatment, in rats with initial moderate deficiency in vitamins B1 and B2.	phthalylsulfathiazole	151-161	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	272-281
9737578-6	1998	In contrast, the mRNA level of UGT1*1 (which metabolizes bilirubin, not phenols) was depressed to 16% of control (P<0.002), while the mRNA level of UGT2B3 (which metabolizes testosterone) was reduced to 53% (P<0.05).	Bilirubin	57-66	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	31-37
9737578-6	1998	In contrast, the mRNA level of UGT1*1 (which metabolizes bilirubin, not phenols) was depressed to 16% of control (P<0.002), while the mRNA level of UGT2B3 (which metabolizes testosterone) was reduced to 53% (P<0.05).	Testosterone	177-189	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	31-37
9737578-7	1998	In primary hepatocyte culture, dexamethasone treatment resulted in a 3.4-fold induction of UGT1*1 mRNA levels (P<0.001) but only a 1.5-fold induction of UGT2B3 (P=0.1).	Dexamethasone	31-44	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	91-97
9737578-8	1998	Interleukin-6 in the presence of dexamethasone resulted in a marked dose-dependent suppression of both UGT1*1 and UGT2B3, although to different degrees.	Dexamethasone	33-46	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	103-109
9841869-2	1998	In the present study the activity and expression of bilirubin UDP-glucuronosyltransferase (UGT1A1) were investigated in livers of BioBreeding/Worcester diabetic, fasted and acetone-treated rats.	Acetone	173-180	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	91-97
9841869-3	1998	Bilirubin glucuronidation was stimulated by all three treatments; this was correlated with an increase in the UGT1A1 protein concentration in hepatic microsomes.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	110-116
9783725-3	1998	The UGT1A6 gene (formerly known as UGT1*06 and UGT1A1) has been suggested to belong to the aryl hydrocarbon (Ah) gene battery, which consists of several genes encoding for drug-metabolising enzymes regulated by dioxin and other ligands of the Ah receptor.	Dioxins	211-217	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	47-53
9202038-3	1997	Following 3,5, 3"-triiodo-L-thyronine (T3) stimulation in vivo, there is a gradual increase in the amount of UGT1A1 mRNA with maximum levels reached 24 h after treatment.	Triiodothyronine	39-41	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	109-115
9202038-4	1997	In comparison, induction with the specific inducer, 3-methylcholanthrene (3-MC), results in maximal levels of UGT1A1 mRNA after 8 h of treatment.	Methylcholanthrene	52-72	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	110-116
9202038-4	1997	In comparison, induction with the specific inducer, 3-methylcholanthrene (3-MC), results in maximal levels of UGT1A1 mRNA after 8 h of treatment.	Methylcholanthrene	74-78	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	110-116
9363838-0	1997	UDP-GT involvement in the enhancement of cell proliferation in thyroid follicular cell proliferative lesions in rats treated with thiourea and vitamin A.	Thiourea	130-138	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
9029056-3	1997	The present study was designed to compare the reactivity and relative glucuronidation efficiencies of opioid agonists, antagonists, and partial agonists with two rat UGT isoforms; UGT1.1, which is generally considered the "bilirubin UGT," and UGT2B1, which has previously been shown to catalyze the glucuronidation of testosterone, chloramphenicol, and (-)-morphine.	Bilirubin	223-232	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	180-186
9029056-3	1997	The present study was designed to compare the reactivity and relative glucuronidation efficiencies of opioid agonists, antagonists, and partial agonists with two rat UGT isoforms; UGT1.1, which is generally considered the "bilirubin UGT," and UGT2B1, which has previously been shown to catalyze the glucuronidation of testosterone, chloramphenicol, and (-)-morphine.	Testosterone	318-330	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	180-186
9029056-3	1997	The present study was designed to compare the reactivity and relative glucuronidation efficiencies of opioid agonists, antagonists, and partial agonists with two rat UGT isoforms; UGT1.1, which is generally considered the "bilirubin UGT," and UGT2B1, which has previously been shown to catalyze the glucuronidation of testosterone, chloramphenicol, and (-)-morphine.	Chloramphenicol	332-347	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	180-186
9029056-3	1997	The present study was designed to compare the reactivity and relative glucuronidation efficiencies of opioid agonists, antagonists, and partial agonists with two rat UGT isoforms; UGT1.1, which is generally considered the "bilirubin UGT," and UGT2B1, which has previously been shown to catalyze the glucuronidation of testosterone, chloramphenicol, and (-)-morphine.	Morphine	353-365	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	180-186
9252437-11	1997	These data suggest that the B1 and B2 receptors potently inhibited PDGF-stimulated mitogenesis and proliferation by activating an alternative signal transduction cascade not involving phosphoinositidase C or prostaglandins.	Prostaglandins	208-222	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	28-37
9224784-0	1997	Glucuronidation of retinoids by rat recombinant UDP: glucuronosyltransferase 1.1 (bilirubin UGT).	Retinoids	19-28	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	48-80
9224784-0	1997	Glucuronidation of retinoids by rat recombinant UDP: glucuronosyltransferase 1.1 (bilirubin UGT).	Bilirubin	82-91	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	48-80
9224784-2	1997	UGT1.1 glucuronidation activity was 91 +/- 18 pmol/mg x min for atRA and 113 +/- 19 pmol/mg x min for 5,6-epoxy-atRA.	Tretinoin	64-68	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
9224784-2	1997	UGT1.1 glucuronidation activity was 91 +/- 18 pmol/mg x min for atRA and 113 +/- 19 pmol/mg x min for 5,6-epoxy-atRA.	5,6-epoxyretinoic acid	102-116	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
9224784-3	1997	The apparent K(M) and V(max) of atRA acid glucuronidation by UGT1.1 were 59.1 +/- 5.4 microM and 158 +/- 43 pmol/mg x min, respectively.	atra acid	32-41	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	61-67
9224784-5	1997	Liver microsomes from Gunn rats, which lack UGT1.1, had significant activity toward atRA (111 +/- 28 pmol/mg x min).	Tretinoin	84-88	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	44-50
9174115-4	1997	Interestingly, treatment with a known inducer of UGT bilirubin, ciprofibrate, induced the hepatic mRNA levels encoding for the UGT1*0 isoform by 3.5-fold and for the UGT1*1 isoform by only twofold.	Bilirubin	53-62	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	166-172
9174115-4	1997	Interestingly, treatment with a known inducer of UGT bilirubin, ciprofibrate, induced the hepatic mRNA levels encoding for the UGT1*0 isoform by 3.5-fold and for the UGT1*1 isoform by only twofold.	ciprofibrate	64-76	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	166-172
9363838-0	1997	UDP-GT involvement in the enhancement of cell proliferation in thyroid follicular cell proliferative lesions in rats treated with thiourea and vitamin A.	Vitamin A	143-152	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
9363838-5	1997	The induction of P450 isoenzymes by TU was not enhanced by VA supplementation, but uridine diphosphate glucuronosyltransferase (UDP-GT) activity in the liver was significantly increased in the TU + VA group compared to the TU group.	tu + va	193-200	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	83-126
9363838-5	1997	The induction of P450 isoenzymes by TU was not enhanced by VA supplementation, but uridine diphosphate glucuronosyltransferase (UDP-GT) activity in the liver was significantly increased in the TU + VA group compared to the TU group.	tu + va	193-200	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	128-134
9363838-5	1997	The induction of P450 isoenzymes by TU was not enhanced by VA supplementation, but uridine diphosphate glucuronosyltransferase (UDP-GT) activity in the liver was significantly increased in the TU + VA group compared to the TU group.	Thiourea	193-195	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	83-126
9363838-5	1997	The induction of P450 isoenzymes by TU was not enhanced by VA supplementation, but uridine diphosphate glucuronosyltransferase (UDP-GT) activity in the liver was significantly increased in the TU + VA group compared to the TU group.	Thiourea	193-195	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	128-134
9363838-8	1997	The results of the present study suggest that enhanced cell proliferation is due to increased TSH stimulation, resulting from the decrease in serum T3/T4 levels brought about by induction of liver UDP-GT activity with the combined action of TU + VA as well as inhibition by TU of thyroid hormone synthesis in the thyroid.	tu + va	241-248	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	197-203
9054958-1	1997	PURPOSE: Irinotecan (CPT-11) is hydrolyzed to its active metabolite SN-38 which is subsequently conjugated by uridine diphosphate glucuronosyl transferase (UDP-GT) to the glucuronide (SN-38G).	Irinotecan	9-19	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	110-154
9054958-1	1997	PURPOSE: Irinotecan (CPT-11) is hydrolyzed to its active metabolite SN-38 which is subsequently conjugated by uridine diphosphate glucuronosyl transferase (UDP-GT) to the glucuronide (SN-38G).	Irinotecan	9-19	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	156-162
9054958-1	1997	PURPOSE: Irinotecan (CPT-11) is hydrolyzed to its active metabolite SN-38 which is subsequently conjugated by uridine diphosphate glucuronosyl transferase (UDP-GT) to the glucuronide (SN-38G).	Irinotecan	21-27	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	110-154
9054958-1	1997	PURPOSE: Irinotecan (CPT-11) is hydrolyzed to its active metabolite SN-38 which is subsequently conjugated by uridine diphosphate glucuronosyl transferase (UDP-GT) to the glucuronide (SN-38G).	Irinotecan	21-27	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	156-162
9054958-1	1997	PURPOSE: Irinotecan (CPT-11) is hydrolyzed to its active metabolite SN-38 which is subsequently conjugated by uridine diphosphate glucuronosyl transferase (UDP-GT) to the glucuronide (SN-38G).	Irinotecan	68-73	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	110-154
9054958-1	1997	PURPOSE: Irinotecan (CPT-11) is hydrolyzed to its active metabolite SN-38 which is subsequently conjugated by uridine diphosphate glucuronosyl transferase (UDP-GT) to the glucuronide (SN-38G).	Irinotecan	68-73	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	156-162
9054958-1	1997	PURPOSE: Irinotecan (CPT-11) is hydrolyzed to its active metabolite SN-38 which is subsequently conjugated by uridine diphosphate glucuronosyl transferase (UDP-GT) to the glucuronide (SN-38G).	Glucuronides	171-182	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	110-154
9054958-1	1997	PURPOSE: Irinotecan (CPT-11) is hydrolyzed to its active metabolite SN-38 which is subsequently conjugated by uridine diphosphate glucuronosyl transferase (UDP-GT) to the glucuronide (SN-38G).	Glucuronides	171-182	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	156-162
9054958-1	1997	PURPOSE: Irinotecan (CPT-11) is hydrolyzed to its active metabolite SN-38 which is subsequently conjugated by uridine diphosphate glucuronosyl transferase (UDP-GT) to the glucuronide (SN-38G).	Irinotecan	184-189	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	110-154
9054958-1	1997	PURPOSE: Irinotecan (CPT-11) is hydrolyzed to its active metabolite SN-38 which is subsequently conjugated by uridine diphosphate glucuronosyl transferase (UDP-GT) to the glucuronide (SN-38G).	Irinotecan	184-189	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	156-162
8812207-6	1996	Liver and thyroid weights, hepatic UDPGT activity, and circulating levels of TSH were significantly increased in animals administered alachlor.	alachlor	134-142	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	35-40
9007042-5	1997	Dose-related changes associated with thiazopyr treatment were significant increases in liver weight, thyroid weight, and hepatic T4-UDPGT activity at high doses.	thiazopyr	37-46	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	132-137
9007042-8	1997	Increased thyroid T4 elimination, primarily via increased hepatic conjugation by T4-UDPGT, resulting in decreased serum T4, appeared to be responsible for the increased TSH levels.	Thyrotropin	169-172	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	84-89
8812207-10	1996	The changes in TSH and T3 levels, hepatic UDPGT activity, and liver weights were all reversible on elimination of alachlor from the diet.	alachlor	114-122	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	42-47
8812207-13	1996	Increased metabolism of T4 via hepatic enzymatic conjugation (i.e., T4-UDPGT) appeared to be responsible for the increased TSH levels.	Thyrotropin	123-126	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	71-76
8820424-5	1996	However, the purified UGT1.1r enzyme exhibited glucuronidation activity toward buprenorphine and bilirubin with high efficiency, but the UGT2B1 protein did not react with these compounds.	Buprenorphine	79-92	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	22-28
8806713-2	1996	We have previously shown that rat UGT1.1, stably expressed in human embryonic kidney 293 cells, catalyzes the glucuronidation of bilirubin and the mixed opioid agonist/antagonist buprenorphine with high efficiency.	Buprenorphine	179-192	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	34-40
8806713-2	1996	We have previously shown that rat UGT1.1, stably expressed in human embryonic kidney 293 cells, catalyzes the glucuronidation of bilirubin and the mixed opioid agonist/antagonist buprenorphine with high efficiency.	Bilirubin	129-138	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	34-40
8820424-5	1996	However, the purified UGT1.1r enzyme exhibited glucuronidation activity toward buprenorphine and bilirubin with high efficiency, but the UGT2B1 protein did not react with these compounds.	Bilirubin	97-106	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	22-28
8817938-1	1996	To evaluate the rate at which the four main aflatoxins (aflatoxins B1, B2, G1 and G2) are able to cross the luminal membrane of the rat small intestine, a study about intestinal absorption kinetics of these mycotoxins has been made.	Aflatoxins	44-54	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	67-84
8632018-4	1996	UGT1A1 is a major 3-methylcholanthrene (MC)-inducible form in rat liver.	Methylcholanthrene	18-38	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
8632018-4	1996	UGT1A1 is a major 3-methylcholanthrene (MC)-inducible form in rat liver.	Methylcholanthrene	40-42	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
8632018-9	1996	When a single base substitution was introduced into the XRE, MC-induced expression of the UGT1A1 gene was completely abolished.	Methylcholanthrene	61-63	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	90-96
8632018-13	1996	These results suggest that the XRE participates in induction of the rat UGT1A1 gene by MC.	Methylcholanthrene	87-89	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	72-78
8554318-2	1995	Among the isozymes expressed in rat hepatic microsomes, UGT1B1 (54 kDa) of bilirubin cluster was found to be a major form and minor forms were identified as UGT1A1 (53 kDa), UGT1B2 (56 kDa), and UGT1B5 (57 kDa).	Bilirubin	75-84	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	157-163
8554318-5	1995	The UGT1A1 and UGT1A2 of the phenol cluster isozymes were significantly induced in 3-methylcholanthrene-treated rats.	Phenol	29-35	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	4-10
8554318-5	1995	The UGT1A1 and UGT1A2 of the phenol cluster isozymes were significantly induced in 3-methylcholanthrene-treated rats.	Methylcholanthrene	83-103	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	4-10
7817994-9	1995	In phase 2, UDPGT activity was quantitated at 0, 2, 4, and 8 weeks using known quantities of bilirubin as substrate.	Bilirubin	93-102	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	12-17
7603447-0	1995	Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin.	Bilirubin	173-182	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	90-121
7603447-9	1995	Expressed UGT1.1r protein catalyzed the glucuronidation of buprenorphine and bilirubin at high rates.	Buprenorphine	59-72	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	10-16
7603447-9	1995	Expressed UGT1.1r protein catalyzed the glucuronidation of buprenorphine and bilirubin at high rates.	Bilirubin	77-86	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	10-16
7603447-10	1995	Other opioids, such as nalorphine and morphine, were also substrates for the expressed UGT1.1r protein.	Nalorphine	23-33	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	87-91
7603447-10	1995	Other opioids, such as nalorphine and morphine, were also substrates for the expressed UGT1.1r protein.	Morphine	38-46	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	87-91
7741768-5	1995	The carbon monoxide complex of reduced P450(b-1) showed an absorption peak at 450.5 nm.	Carbon Monoxide	4-19	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	39-48
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	Aminopyrine	74-85	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	36-44
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	Aminopyrine	74-85	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	158-166
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	Benzo(a)pyrene	87-101	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	36-44
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	Benzo(a)pyrene	87-101	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	158-166
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	7-ethoxycoumarin	103-119	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	36-44
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	7-ethoxycoumarin	103-119	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	158-166
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	Imipramine	121-131	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	36-44
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	Imipramine	121-131	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	158-166
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	Propranolol	136-147	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	36-44
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	Propranolol	136-147	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	158-166
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	Aminopyrine	192-203	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	36-44
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	Aminopyrine	192-203	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	158-166
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	imipramine n	224-236	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	36-44
7741768-6	1995	The reconstituted system containing P450(b-1) catalyzed the metabolism of aminopyrine, benzo[a]pyrene, 7-ethoxycoumarin, imipramine and propranolol, of which P450(b-1) most strongly catalyzed aminopyrine N-demethylation and imipramine N-demethylation.	imipramine n	224-236	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	158-166
7817994-19	1995	Wistar rat UDPGT activity in intestine and liver averaged 0.61 +/- 0.05 and 1.88 +/- 0.06 mg bilirubin conjugated/mg tissue per hour, respectively.	Bilirubin	93-102	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	11-16
8004726-0	1994	Camelliasaponins B1, B2, C1 and C2, new type inhibitors of ethanol absorption in rats from the seeds of Camellia japonica L. New type inhibitors of ethanol absorption, camelliasaponins B1, B2, C1 and C2, were isolated from the seeds of Camellia japonica L. The structures of camelliasaponins were elucidated on the basis of chemical and physicochemical evidence.	Ethanol	59-66	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	17-34
7698007-0	1995	Mapping of rat bilirubin UDP-glucuronosyl-transferase gene (Ugt1a1) to chromosome region 9q35-->q36.	Bilirubin	15-24	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	60-66
7698007-2	1995	A 1,763-bp cDNA probe (UGT1*0) specific for rat liver bilirubin UGT was used to localize the UGT1 complex locus (Ugt1a1) to chromosome region 9q35-->q36 by fluorescence in situ hybridization.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	113-119
7892299-8	1995	In males, B1, B2, C2, and C3 increased basal levels of LH.	Luteinizing Hormone	55-57	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	10-28
8185651-2	1994	6-Hydroxychrysene was used as a functional probe of UGT1A1 activity.	6-hydroxychrysene	0-17	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	52-58
8185651-4	1994	After treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 10 micrograms/kg for 7 days) the UGT1A1 mRNA level was markedly increased in liver (ca.	Polychlorinated Dibenzodioxins	21-56	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	97-103
8185651-4	1994	After treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 10 micrograms/kg for 7 days) the UGT1A1 mRNA level was markedly increased in liver (ca.	Polychlorinated Dibenzodioxins	58-62	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	97-103
8185651-8	1994	The results suggest complex tissue-specific regulation of UGT1A1 including positive and negative transcriptional factors and marked inducibility by TCDD in liver.	Polychlorinated Dibenzodioxins	148-152	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	58-64
7510863-5	1994	A single-exposure of B1/PKC cells to 5-azacytidine (AZA), followed by growth in the absence of this demethylating agent, results in B1/PKC-AZA clones which display a stable reversion of the progression phenotype to that of the unprogressed parental E11 clone.	Azacitidine	37-50	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	132-142
7510863-5	1994	A single-exposure of B1/PKC cells to 5-azacytidine (AZA), followed by growth in the absence of this demethylating agent, results in B1/PKC-AZA clones which display a stable reversion of the progression phenotype to that of the unprogressed parental E11 clone.	Azacitidine	52-55	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	132-142
7510863-8	1994	TPA cannot induce the progression phenotype in B1/PKC-AZA cells, but it can reversibly induce an increase in the transcriptional rate and steady-state mRNA levels of PKC beta 1 and c-jun and it increases AP-1 DNA-binding.	Tetradecanoylphorbol Acetate	0-3	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	47-57
8118934-5	1994	Pretreatment of rats with 3-methylcholanthrene (MC), a dioxin-type inducer of CYP1A isozymes and phenol UDP-glucuronosyltransferase (UGT1A1), led to a dramatic decrease of N-acetylated (2% of total metabolites) and an increase of N-hydroxylated (54% as free and glucuronidated compound) and ring-hydroxylated (35%) metabolites.	Methylcholanthrene	26-46	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	133-139
8118934-5	1994	Pretreatment of rats with 3-methylcholanthrene (MC), a dioxin-type inducer of CYP1A isozymes and phenol UDP-glucuronosyltransferase (UGT1A1), led to a dramatic decrease of N-acetylated (2% of total metabolites) and an increase of N-hydroxylated (54% as free and glucuronidated compound) and ring-hydroxylated (35%) metabolites.	Methylcholanthrene	48-50	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	133-139
8118934-5	1994	Pretreatment of rats with 3-methylcholanthrene (MC), a dioxin-type inducer of CYP1A isozymes and phenol UDP-glucuronosyltransferase (UGT1A1), led to a dramatic decrease of N-acetylated (2% of total metabolites) and an increase of N-hydroxylated (54% as free and glucuronidated compound) and ring-hydroxylated (35%) metabolites.	Phenol	97-103	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	133-139
8004726-0	1994	Camelliasaponins B1, B2, C1 and C2, new type inhibitors of ethanol absorption in rats from the seeds of Camellia japonica L. New type inhibitors of ethanol absorption, camelliasaponins B1, B2, C1 and C2, were isolated from the seeds of Camellia japonica L. The structures of camelliasaponins were elucidated on the basis of chemical and physicochemical evidence.	Ethanol	148-155	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	17-34
8216382-4	1993	The results demonstrate that (R)-naproxen represents a stereoselective substrate of rat UGT1A1, but not of the human orthologous UGT1A1.	(R)-Naproxen	29-41	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	88-94
8216382-0	1993	Stereoselective glucuronidation of (R)- and (S)-naproxen by recombinant rat phenol UDP-glucuronosyltransferase (UGT1A1) and its human orthologue.	(r)- and (s)-naproxen	35-56	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	112-118
1494105-0	1992	Influence of para substituent of phenol on phospholipid dependence of uridine diphosphate-glucuronyltransferase.	Phenol	33-39	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	70-111
8216382-1	1993	Recombinant rat phenol UDP-glucuronosyltransferase (UGT1A1) conjugates (R)-naproxen at a much higher rate (> 17-fold) than its (S)-enantiomer, substantiating previous findings on stereoselective glucuronidation of racemic naproxen.	(R)-Naproxen	71-83	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	52-58
8216382-1	1993	Recombinant rat phenol UDP-glucuronosyltransferase (UGT1A1) conjugates (R)-naproxen at a much higher rate (> 17-fold) than its (S)-enantiomer, substantiating previous findings on stereoselective glucuronidation of racemic naproxen.	Naproxen	75-83	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	52-58
8216382-3	1993	In line with high constitutive expression of UGT1A1 in extrahepatic tissues, a high R/S ratio of naproxen glucuronidation was found in rat testes, intestine, lung and kidney.	Naproxen	97-105	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	45-51
8508509-2	1993	Here we investigated the potential roles of hepatic glutathione-S-transferase (GST; EC 2.5.1.18) and uridine diphosphoglucuronosyl transferase (UDPGT; EC 2.4.1.17) in monoterpene-mediated chemoprevention.	Monoterpenes	167-178	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	101-142
8508509-7	1993	Both terpene diets significantly increased the activity of the methylcholanthrene-inducible and the phenobarbital-inducible UDPGT isozymes.	Terpenes	5-12	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	124-129
8508509-7	1993	Both terpene diets significantly increased the activity of the methylcholanthrene-inducible and the phenobarbital-inducible UDPGT isozymes.	Phenobarbital	100-113	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	124-129
8508509-8	1993	We propose that much of the anticarcinogenic activity of these monocyclic monoterpenes during the initiation phase of DMBA carcinogenesis is mediated through the induction of the hepatic detoxification enzymes GST and UDPGT.	Monoterpenes	74-86	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	218-223
8508509-8	1993	We propose that much of the anticarcinogenic activity of these monocyclic monoterpenes during the initiation phase of DMBA carcinogenesis is mediated through the induction of the hepatic detoxification enzymes GST and UDPGT.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	118-122	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	218-223
8364501-5	1993	These results are discussed in association with van der Waals volume (Vw) of substituent and phospholipid dependence of UDPGT.	Phospholipids	93-105	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	120-125
8243107-1	1993	The effect of oral consumption of 200 +/- 100 ppb of crude aflatoxin (B1, B2, G1, G2) showed testicular degeneration and a decrease in the meiotic index.	Aflatoxins	59-68	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	70-84
8347144-12	1993	UDP-glucuronosyltransferase (UGT) activities towards 3-OH-BP (UGT1A1) and 4-OH-biphenyl (UGT2B1) were also determined.	3-hydroxybenzo(a)pyrene	53-60	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	62-68
8494539-1	1993	Stably expressed human and rat phenol UDP-glucuronosyltransferases (UGTs) of the UGT1 complex (HlugP1, HlugP4 and 3-methylcholanthrene-inducible rat UGT1A1, the latter considered to be an orthologous enzyme to HlugP1) have been used to investigate the role of UGTs in paracetamol glucuronidation.	Methylcholanthrene	116-134	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	81-85
8494539-1	1993	Stably expressed human and rat phenol UDP-glucuronosyltransferases (UGTs) of the UGT1 complex (HlugP1, HlugP4 and 3-methylcholanthrene-inducible rat UGT1A1, the latter considered to be an orthologous enzyme to HlugP1) have been used to investigate the role of UGTs in paracetamol glucuronidation.	Methylcholanthrene	116-134	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	149-155
8494539-1	1993	Stably expressed human and rat phenol UDP-glucuronosyltransferases (UGTs) of the UGT1 complex (HlugP1, HlugP4 and 3-methylcholanthrene-inducible rat UGT1A1, the latter considered to be an orthologous enzyme to HlugP1) have been used to investigate the role of UGTs in paracetamol glucuronidation.	Acetaminophen	268-279	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	81-85
8494539-10	1993	The results demonstrate that paracetamol is conjugated by HlugP1 and its rat orthologue UGT1A1 with higher affinity than by HlugP4 and other UGTs.	Acetaminophen	29-40	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	88-94
1494105-0	1992	Influence of para substituent of phenol on phospholipid dependence of uridine diphosphate-glucuronyltransferase.	Phospholipids	43-55	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	70-111
1494105-1	1992	The influence of para substituent of phenol on the property of phospholipid dependence of uridine diphosphate-glucuronyltransferase (UDPGT) was studied using hepatic microsomes of the rats.	Phenol	37-43	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	90-131
1494105-1	1992	The influence of para substituent of phenol on the property of phospholipid dependence of uridine diphosphate-glucuronyltransferase (UDPGT) was studied using hepatic microsomes of the rats.	Phenol	37-43	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	133-138
1494105-1	1992	The influence of para substituent of phenol on the property of phospholipid dependence of uridine diphosphate-glucuronyltransferase (UDPGT) was studied using hepatic microsomes of the rats.	Phospholipids	63-75	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	90-131
1494105-1	1992	The influence of para substituent of phenol on the property of phospholipid dependence of uridine diphosphate-glucuronyltransferase (UDPGT) was studied using hepatic microsomes of the rats.	Phospholipids	63-75	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	133-138
1479538-0	1992	Species difference and tissue distribution of uridine diphosphate-glucuronyltransferase activities toward E6080, 1-naphthol and 4-hydroxybiphenyl.	E 6080	106-111	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	46-87
1435739-0	1992	Mono- and diglucuronide formation from chrysene and benzo(a)pyrene phenols by 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase (UGT1A1).	mono- and diglucuronide	0-23	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	145-151
1435739-0	1992	Mono- and diglucuronide formation from chrysene and benzo(a)pyrene phenols by 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase (UGT1A1).	chrysene	39-47	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	145-151
1435739-0	1992	Mono- and diglucuronide formation from chrysene and benzo(a)pyrene phenols by 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase (UGT1A1).	benzo(a)pyrene phenols	52-74	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	145-151
1435739-0	1992	Mono- and diglucuronide formation from chrysene and benzo(a)pyrene phenols by 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase (UGT1A1).	Methylcholanthrene	78-98	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	145-151
1435739-1	1992	Mono- and diphenols of chrysene and benzo(a)pyrene are suspected substrates of a 3-methylcholanthrene (MC)-inducible phenol UDP-glucuronosyltransferase (UGT1A1).	mono- and diphenols	0-19	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	153-159
1435739-1	1992	Mono- and diphenols of chrysene and benzo(a)pyrene are suspected substrates of a 3-methylcholanthrene (MC)-inducible phenol UDP-glucuronosyltransferase (UGT1A1).	chrysene	23-31	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	153-159
1435739-1	1992	Mono- and diphenols of chrysene and benzo(a)pyrene are suspected substrates of a 3-methylcholanthrene (MC)-inducible phenol UDP-glucuronosyltransferase (UGT1A1).	Benzo(a)pyrene	36-50	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	153-159
1435739-1	1992	Mono- and diphenols of chrysene and benzo(a)pyrene are suspected substrates of a 3-methylcholanthrene (MC)-inducible phenol UDP-glucuronosyltransferase (UGT1A1).	Methylcholanthrene	81-101	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	153-159
1435739-1	1992	Mono- and diphenols of chrysene and benzo(a)pyrene are suspected substrates of a 3-methylcholanthrene (MC)-inducible phenol UDP-glucuronosyltransferase (UGT1A1).	Methylcholanthrene	103-105	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	153-159
1435739-5	1992	Induction factors obtained for monoglucuronide formation (but not for diglucuronide formation) were in line with published data on the increase of immunodetectable UGT1A1 protein and of its mRNA.	monoglucuronide	31-46	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	164-170
1435739-6	1992	It is suggested that the high induction factors for diglucuronide formation are the result of a combination of the induction of UGT1A1 and facilitated interaction of neighboring UGT1A1 molecules in endoplasmic reticulum membranes.	diglucuronide	52-65	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	128-134
1435739-6	1992	It is suggested that the high induction factors for diglucuronide formation are the result of a combination of the induction of UGT1A1 and facilitated interaction of neighboring UGT1A1 molecules in endoplasmic reticulum membranes.	diglucuronide	52-65	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	178-184
1479538-0	1992	Species difference and tissue distribution of uridine diphosphate-glucuronyltransferase activities toward E6080, 1-naphthol and 4-hydroxybiphenyl.	1-naphthol	113-123	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	46-87
1479538-0	1992	Species difference and tissue distribution of uridine diphosphate-glucuronyltransferase activities toward E6080, 1-naphthol and 4-hydroxybiphenyl.	4-phenylphenol	128-145	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	46-87
1479538-1	1992	The apparent in vitro kinetic constants of uridine diphosphate-glucuronyltransferase (UDP-GT) activities towards E6080, 1-naphthol (1-N) and 4-hydroxybiphenyl (4-HB) were determined using microsomes, to assess the effect of inducing agents and evaluate species and tissue differences.	E 6080	113-118	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	43-84
1479538-1	1992	The apparent in vitro kinetic constants of uridine diphosphate-glucuronyltransferase (UDP-GT) activities towards E6080, 1-naphthol (1-N) and 4-hydroxybiphenyl (4-HB) were determined using microsomes, to assess the effect of inducing agents and evaluate species and tissue differences.	E 6080	113-118	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	86-92
1479538-1	1992	The apparent in vitro kinetic constants of uridine diphosphate-glucuronyltransferase (UDP-GT) activities towards E6080, 1-naphthol (1-N) and 4-hydroxybiphenyl (4-HB) were determined using microsomes, to assess the effect of inducing agents and evaluate species and tissue differences.	1-naphthol	120-130	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	43-84
1479538-1	1992	The apparent in vitro kinetic constants of uridine diphosphate-glucuronyltransferase (UDP-GT) activities towards E6080, 1-naphthol (1-N) and 4-hydroxybiphenyl (4-HB) were determined using microsomes, to assess the effect of inducing agents and evaluate species and tissue differences.	1-naphthol	120-130	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	86-92
33762933-16	2021	Our findings show that hyperbilirubinemia is associated with reduced fat mass, and increased hepatic mitochondrial biogenesis, specifically in female animals, suggesting a dual role of elevated bilirubin and reduced UGT1A1 function on adiposity and body composition.	Bilirubin	28-37	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	216-222
1597129-3	1992	To study the mechanism of this potential competition between AP and ZDV as substrates for uridine diphosphoglucuronyltransferase (UDPGT), enzyme kinetic studies were performed using rat liver microsome preparations.	Zidovudine	68-71	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	90-128
1597129-3	1992	To study the mechanism of this potential competition between AP and ZDV as substrates for uridine diphosphoglucuronyltransferase (UDPGT), enzyme kinetic studies were performed using rat liver microsome preparations.	Zidovudine	68-71	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	130-135
1915898-3	1991	Both B1 and B2 chains, but not A, were found in medium from 5-day-old lipocyte primary cultures by immunoblotting and immunoprecipitation of 35S-labeled proteins after reducing SDS-polyacrylamide gel electrophoresis.	Sulfur-35	141-144	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	5-14
1915898-3	1991	Both B1 and B2 chains, but not A, were found in medium from 5-day-old lipocyte primary cultures by immunoblotting and immunoprecipitation of 35S-labeled proteins after reducing SDS-polyacrylamide gel electrophoresis.	Sodium Dodecyl Sulfate	177-180	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	5-14
1915898-3	1991	Both B1 and B2 chains, but not A, were found in medium from 5-day-old lipocyte primary cultures by immunoblotting and immunoprecipitation of 35S-labeled proteins after reducing SDS-polyacrylamide gel electrophoresis.	polyacrylamide gels	181-199	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	5-14
1804560-0	1991	Phospholipid dependency of hepatic uridine diphosphate-glucuronyltransferase in the developing fetus of the rat.	Phospholipids	0-12	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	35-76
1804560-3	1991	Lipid removal with phospholipase A2 greatly reduced UDPGT activity for phenol in the later stage of gestation, even though the delipidation ratios in both stages were similar.	Phenol	71-77	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	52-57
2128752-4	1990	Inducibility of liver microsomal codeine UDPGT activity in rats was examined by pretreatment with phenobarbital and 3-methylcholanthrene and compared with those of other UDPGT activities.	Codeine	33-40	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	41-46
2128752-4	1990	Inducibility of liver microsomal codeine UDPGT activity in rats was examined by pretreatment with phenobarbital and 3-methylcholanthrene and compared with those of other UDPGT activities.	Phenobarbital	98-111	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	41-46
2128752-4	1990	Inducibility of liver microsomal codeine UDPGT activity in rats was examined by pretreatment with phenobarbital and 3-methylcholanthrene and compared with those of other UDPGT activities.	Methylcholanthrene	116-136	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	41-46
2128752-6	1990	The inducibility of codeine UDPGT activity by phenobarbital pretreatment was not as high as that of morphine UDPGT activity.	Codeine	20-27	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	28-33
2128752-6	1990	The inducibility of codeine UDPGT activity by phenobarbital pretreatment was not as high as that of morphine UDPGT activity.	Phenobarbital	46-59	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	28-33
2128752-2	1990	Codeine UDPGT activity was the highest in guinea pigs, followed by that in rabbits, and the lowest in mice and rats among these four animal species.	Codeine	0-7	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	8-13
2133311-4	1990	Calcium release at 24 h was significantly different in the cells treated with New B-1 and New B-5 than in controls.	Calcium	0-7	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	82-85
35099041-12	2022	Furthermore, B1-6-12 is effective against these abnormalities and deserves further investigations as potential treatment for cisplatin-induced neuropathy.	Cisplatin	125-134	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	13-17
34698602-5	2021	Atazanavir inhibited the production of beta-estradiol 3-beta-D-glucuronide with IC50 values of 0.54 microM and 0.16 microM in HLM and rUGT1A1, respectively.	Atazanavir Sulfate	0-10	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	134-141
34698602-5	2021	Atazanavir inhibited the production of beta-estradiol 3-beta-D-glucuronide with IC50 values of 0.54 microM and 0.16 microM in HLM and rUGT1A1, respectively.	estradiol-3-glucuronide	39-74	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	134-141
35445507-10	2022	In addition, DEX increased Nr1i2, Ugt1a1, and Abcc2 (Mrp2) mRNA levels in the primary fetal hepatocytes.	Dexamethasone	13-16	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	34-40
35445507-11	2022	The Nr3c1 or Nr1i2 siRNA-mediated knockdown suppressed the increases of Ugt1a1, and Abcc2 mRNA levels induced by DEX, indicating that DEX are mediated by GC receptor and PXR in primary fetal hepatocytes.	Dexamethasone	113-116	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	72-78
35445507-11	2022	The Nr3c1 or Nr1i2 siRNA-mediated knockdown suppressed the increases of Ugt1a1, and Abcc2 mRNA levels induced by DEX, indicating that DEX are mediated by GC receptor and PXR in primary fetal hepatocytes.	Dexamethasone	134-137	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	72-78
34220516-9	2021	This study found obvious changes in the pharmacokinetics of acetaminophen and metformin hydrochloride in rats after exposure to simulated high altitude hypoxia, and they might be due to significant decreases in the expressions of UGT1A1 and OCT2.	Acetaminophen	60-73	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	230-236
34220516-9	2021	This study found obvious changes in the pharmacokinetics of acetaminophen and metformin hydrochloride in rats after exposure to simulated high altitude hypoxia, and they might be due to significant decreases in the expressions of UGT1A1 and OCT2.	Metformin	78-101	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	230-236
35405201-8	2022	The phase II Sult and Ugt enzymes were mostly upregulated in the STZ-G12w rats (Sult1a1, Sult1e1, Ugt1a1, Ugt1a7c, Ugt1a6, Ugt2b35 and Ugt2b17) and normally expressed in the STZ-G3w group (Sult2a2, Sult2a6, Sult2b1, Ugt2b7, Sult4a1 and Ugt1a7c).	Streptozocin	65-68	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	98-104
35041917-6	2022	Meanwhile, our experimental results demonstrated that the beneficial effect of PF-PLC micelles on EE-induced cholestasis may be achieved by the upregulation of nuclear receptors and metabolic enzymes (PXR/CAR/UGT1A1).	pf-plc	79-85	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	209-215