PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 25375189-6 2014 DNP treatment altered the phosphorylation of ezrin (threonine 567), vimentin (serine 55), stathmin (serine 25) and STAT3 (serine 727). N,N'-dinitrosopiperazine 0-3 vimentin Homo sapiens 68-76 25150162-6 2014 Quercetin prevented EGF-induced expression of N-cadherin and vimentin and increased the expression of E-cadherin in PC-3 cells, therefore preventing EGF-induced EMT. Quercetin 0-9 vimentin Homo sapiens 61-69 25958528-2 2014 Vimentins at the cell surface are recently known to bind N-acetylglucosamine (GlcNAc) residue, therefore, the cell surfaces of vimentin-expressing cells could be targeted by using the GlcNAc residue as a specific ligand for receptor-mediated gene delivery. Acetylglucosamine 57-76 vimentin Homo sapiens 127-135 25958528-2 2014 Vimentins at the cell surface are recently known to bind N-acetylglucosamine (GlcNAc) residue, therefore, the cell surfaces of vimentin-expressing cells could be targeted by using the GlcNAc residue as a specific ligand for receptor-mediated gene delivery. Acetylglucosamine 78-84 vimentin Homo sapiens 127-135 25958528-2 2014 Vimentins at the cell surface are recently known to bind N-acetylglucosamine (GlcNAc) residue, therefore, the cell surfaces of vimentin-expressing cells could be targeted by using the GlcNAc residue as a specific ligand for receptor-mediated gene delivery. Acetylglucosamine 184-190 vimentin Homo sapiens 127-135 25958528-10 2014 The high transfection efficiency of PADPG was attributed to the GlcNAc in the polymeric vector which interact specifically with vimentin in the cells for the receptor-mediated endocytosis. Acetylglucosamine 64-70 vimentin Homo sapiens 128-136 25958528-12 2014 Thus, this study demonstrates that conjugation of GlcNAc is an effective and rational way to prepare a suitable vector for targeted gene delivery to vimentin-expressing cells. Acetylglucosamine 50-56 vimentin Homo sapiens 149-157 24648251-4 2014 Withaferin A (WFA), a vimentin targeting drug is shown to disrupt endothelial barrier function through its effects on vimentin filament distribution and physical properties. withaferin A 0-12 vimentin Homo sapiens 22-30 25344679-9 2014 Western blot analysis showed that FTY720 induced cleavage of caspases 3, 8 and 9, and of PARP, in a dose-dependent manner, consistent with a substantial decrease in p-STAT3, Bcl-xL, Bcl-2, survivin, cyclin D1, cyclin E, N-cadherin, vimentin, VEGF and TWIST1. Fingolimod Hydrochloride 34-40 vimentin Homo sapiens 232-240 25329306-6 2014 Importantly, western blot analysis revealed that triclosan-treated cells exhibited decreased E-cadherin, while the levels of EMT markers, namely N-cadherin, vimentin, snail and slug were found to be significantly up-regulated. Triclosan 49-58 vimentin Homo sapiens 157-165 24648251-4 2014 Withaferin A (WFA), a vimentin targeting drug is shown to disrupt endothelial barrier function through its effects on vimentin filament distribution and physical properties. withaferin A 0-12 vimentin Homo sapiens 118-126 24648251-4 2014 Withaferin A (WFA), a vimentin targeting drug is shown to disrupt endothelial barrier function through its effects on vimentin filament distribution and physical properties. withaferin A 14-17 vimentin Homo sapiens 22-30 24648251-4 2014 Withaferin A (WFA), a vimentin targeting drug is shown to disrupt endothelial barrier function through its effects on vimentin filament distribution and physical properties. withaferin A 14-17 vimentin Homo sapiens 118-126 25201727-7 2014 Metformin could inhibit TGF-beta-induced EMT in Vcap cells, as manifested by inhibition of the increase of N-cadherin (p=0.013), Vimentin (p=0.002) and the decrease of E-cadherin (p=0.0023) and beta-catenin (p=0.034) at mRNA and protein levels. Metformin 0-9 vimentin Homo sapiens 129-137 25380869-14 2014 CONCLUSIONS: The reason for resistance to carbapenems in the majority (68%) of P aeruginosa strains isolated at the evaluated hospital was the presence of VIM carbapenemase. Carbapenems 42-53 vimentin Homo sapiens 155-158 24645915-9 2014 Moreover, co-culture with CAFs induced upregulation of the EMT markers fibronectin and vimentin, downregulation of E-cadherin, and enhanced invasion in SCC9 cells. cafs 26-30 vimentin Homo sapiens 87-95 25038821-12 2014 Treatment with sesamin significantly reduced the expression of nuclear NF-kappaB, IL-6, p-Stat3, Twist and Vimentin (a mesenchymal marker) in SP cells. sesamin 15-22 vimentin Homo sapiens 107-115 25268751-6 2014 Fluvastatin treatment caused proteolysis of vimentin, a marker of epithelial to mesenchymal transition. Fluvastatin 0-11 vimentin Homo sapiens 44-52 25268751-8 2014 Interestingly, fluvastatin neither caused an appreciable cell death nor did modulate vimentin expression in normal mammary epithelial cells. Fluvastatin 15-26 vimentin Homo sapiens 85-93 25268751-9 2014 In conclusion, fluvastatin alters levels of cytoskeletal proteins, primarily targeting vimentin through increased caspase-3- mediated proteolysis, thereby suggesting a role for vimentin in statin-induced breast cancer cell death. Fluvastatin 15-26 vimentin Homo sapiens 87-95 25268751-9 2014 In conclusion, fluvastatin alters levels of cytoskeletal proteins, primarily targeting vimentin through increased caspase-3- mediated proteolysis, thereby suggesting a role for vimentin in statin-induced breast cancer cell death. Fluvastatin 15-26 vimentin Homo sapiens 177-185 24458546-5 2014 In the presence of TAMs, H6c7, and Colo357 cells showed an elongated cell shape along with an increased expression of mesenchymal markers such as vimentin and reduced expression of epithelial E-cadherin. tams 19-23 vimentin Homo sapiens 146-154 25116803-7 2014 alpha-Solanine also significantly elevates epithelial marker E-cadherin expression, while it concomitantly decreases mesenchymal marker vimentin expression, suggesting it suppresses epithelial-mesenchymal transition (EMT). alpha-solanine 0-14 vimentin Homo sapiens 136-144 24637576-4 2014 To study the detailed mechanisms, studies were carried out on MCF-7 cells and it was found that oroxylin A could regulate the expression of related markers in MCF-7 cells including E-cadherin, N-cadherin, and Vimentin. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 96-106 vimentin Homo sapiens 209-217 25149531-6 2014 In addition, cells treated with rapamycin showed a significant increase in p-Akt and a decrease in p-p70S6K that was associated with a decrease expression of vimentin and a slight increase expression in N-cadherin. Sirolimus 32-41 vimentin Homo sapiens 158-166 24952458-6 2014 Although, molecular mechanisms of actin and vimentin disruption by the applied cytoskeletal drugs, Cytochalasin-D and Withaferin-A, are different, cell softening in both cases can be attributed to reduction of the effective density and stiffness of filament networks. Cytochalasin D 99-113 vimentin Homo sapiens 44-52 24952458-6 2014 Although, molecular mechanisms of actin and vimentin disruption by the applied cytoskeletal drugs, Cytochalasin-D and Withaferin-A, are different, cell softening in both cases can be attributed to reduction of the effective density and stiffness of filament networks. withaferin A 118-130 vimentin Homo sapiens 44-52 24952458-11 2014 These insights add functional cues to frequently observed overexpression of vimentin in diverse types of cancer and underline the role of vimentin targeting drugs, such as Withaferin-A, as a potent cancerostatic supplement. withaferin A 172-184 vimentin Homo sapiens 76-84 24952458-11 2014 These insights add functional cues to frequently observed overexpression of vimentin in diverse types of cancer and underline the role of vimentin targeting drugs, such as Withaferin-A, as a potent cancerostatic supplement. withaferin A 172-184 vimentin Homo sapiens 138-146 24894646-5 2014 The trends of characteristic protein expression, including that of nestin, vimentin, GFAP and glutamine synthetase, for astrocytes cultured on super water-repellent fractal PPP surfaces approximate more to in vivo pattern. Water 149-154 vimentin Homo sapiens 75-83 24944076-3 2014 Here, we show that PTE decreases the vimentin expression, but that the effect was transient. pterostilbene 19-22 vimentin Homo sapiens 37-45 24889918-10 2014 Treating CNE2Z cells with LY294002 inhibited p-Akt (Ser473), vimentin and alpha-SMA expression but upregulated E-cadherin expression, leading to significantly attenuated cell invasion and migration. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 26-34 vimentin Homo sapiens 61-69 24889918-11 2014 Administration of mice with LY294002 resulted in upregulation of membrane E-cadherin, and downregulation of vimentin and alpha-SMA in CNE2Z xenografts, with reduced pulmonary metastasis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 vimentin Homo sapiens 108-116 25024609-9 2014 Clobenpropit up-regulated E-cadherin, but down-regulated vimentin and matrix metalloproteinase 9 in real-time polymerase chain reaction. clobenpropit 0-12 vimentin Homo sapiens 57-65 23082947-9 2014 Staining for vimentin was positive in 7 (6%) of TB, 11 (11%) of IE, and 5 (5%) of LS specimens. Terbium 48-50 vimentin Homo sapiens 13-21 24845378-5 2014 Montelukast inhibited co-culture associated morphological changes of BEAS-2b cells, decreased the expression of vimentin and collagen I, and increased the expression of E-cadherin. montelukast 0-11 vimentin Homo sapiens 112-120 24325816-3 2014 The exposure of palmitate and lipopolysaccharide (LPS) to HepG2 cells enhanced caspase-3 activity and vimentin expression, respectively. Palmitates 16-25 vimentin Homo sapiens 102-110 24754877-6 2014 GLA induced the mesenchymal-epithelial transition in vitro and in vivo, as determined by increased expression of the epithelial marker, E-cadherin, and decreased expression of the mesenchymal marker, vimentin. glabridin 0-3 vimentin Homo sapiens 200-208 24737666-3 2014 A recent report suggests that advanced glycosylation end products, especially N(epsilon) -(carboxymethyl)lysine (CML) modification of vimentin, accelerate the aging process. N(6)-carboxymethyllysine 78-111 vimentin Homo sapiens 134-142 24789180-0 2014 Use of imipenem to detect KPC, NDM, OXA, IMP, and VIM carbapenemase activity from gram-negative rods in 75 minutes using liquid chromatography-tandem mass spectrometry. Imipenem 7-15 vimentin Homo sapiens 50-53 24737666-3 2014 A recent report suggests that advanced glycosylation end products, especially N(epsilon) -(carboxymethyl)lysine (CML) modification of vimentin, accelerate the aging process. N(6)-carboxymethyllysine 113-116 vimentin Homo sapiens 134-142 24756461-5 2014 Additionally, under high glucose conditions it was found that E-cadherin expression was decreased and vimentin expression was increased in HPMCs, suggesting HPMCs underwent EMT. Glucose 25-32 vimentin Homo sapiens 102-110 24249671-9 2014 Although the downregulation of E-cadherin was not shown in MKN-1 cells, Tipalpha induced the expression of vimentin, a significant marker of the epithelial-mesenchymal transition (EMT). tipalpha 72-80 vimentin Homo sapiens 107-115 24704312-5 2014 However, striatal levels of cleaved vimentin and heat shock protein-27 were increased (by 98%-211%, P<0.05), with positive correlations (r=0.41-0.60) observed between concentrations of truncated heat shock protein-27 and extent of dopamine loss (P=0.006) and levels of lipid peroxidation products 4-hydroxynonenal (P=0.046) and malondialdehyde (P=0.11). Dopamine 234-242 vimentin Homo sapiens 36-44 24704312-5 2014 However, striatal levels of cleaved vimentin and heat shock protein-27 were increased (by 98%-211%, P<0.05), with positive correlations (r=0.41-0.60) observed between concentrations of truncated heat shock protein-27 and extent of dopamine loss (P=0.006) and levels of lipid peroxidation products 4-hydroxynonenal (P=0.046) and malondialdehyde (P=0.11). 4-hydroxy-2-nonenal 300-316 vimentin Homo sapiens 36-44 24704312-5 2014 However, striatal levels of cleaved vimentin and heat shock protein-27 were increased (by 98%-211%, P<0.05), with positive correlations (r=0.41-0.60) observed between concentrations of truncated heat shock protein-27 and extent of dopamine loss (P=0.006) and levels of lipid peroxidation products 4-hydroxynonenal (P=0.046) and malondialdehyde (P=0.11). Malondialdehyde 331-346 vimentin Homo sapiens 36-44 24461517-4 2014 We found that miRNA-99a antagonism significantly increased proliferation, migration and invasion abilities of AsPC-1 cells, which was accompanied by increased expression of mesenchymal phenotype cell biomarkers (N-cadherin, Vimentin, and alpha-SMA), and decreased expression of epithelial phenotype cell biomarker (E-cadherin). mirna-99a 14-23 vimentin Homo sapiens 224-232 24607566-6 2014 Finally, PAD inhibition also hinders calcium-induced cytoskeleton disassembly and association of PAD3 with vimentin, that we show to be associated also with AIF; together this suggests that PAD-dependent cytoskeleton disassembly may play a role in AIF translocation to the nucleus. Calcium 37-44 vimentin Homo sapiens 107-115 24932308-9 2014 The protein levels of the mesenchymal markers, vimentin, neural cadherin and Snail, were decreased; however, the expression of the epithelial marker, epithelial cadherin, was increased in the GC cell lines treated with DAPT. dapt 219-223 vimentin Homo sapiens 47-55 24691442-9 2014 Using MultiOmyx, a multiplex immunofluorescence-based methodology, we observed coexpression of cytosolic PLAC8, CDH3, and VIM at the leading edge of a human colorectal tumor, supporting a role for PLAC8 in cancer invasion in vivo. multiomyx 6-15 vimentin Homo sapiens 122-125 24613608-9 2014 As well as the globally relevant carbapenemases (bla(NDM), bla(VIM) and bla(GES)), there are other unknown gene(s) or variant(s) in circulation able to hydrolyse carbapenems and confer high-level resistance. Carbapenems 162-173 vimentin Homo sapiens 63-66 24850148-3 2014 Citrullinated vimentin is found in ionomycin-induced macrophage apoptosis. Ionomycin 35-44 vimentin Homo sapiens 14-22 24657702-5 2014 METHODS: Recombinant human vimentin was conjugated to MagPlex beads using standard carbodiimide/NHS chemistry and coupling efficiency tested and assay parameters determined using a commercial anti-vimentin polyclonal antibody. Carbodiimides 84-96 vimentin Homo sapiens 27-35 24313357-8 2014 Univariate analysis showed that pathologic node status (P < 0.001), alpha-SMA (P = 0.001), and vimentin expression (P = 0.044) was significantly associated with overall survival time, but multivariate analysis just showed the alpha-SMA expression (P = 0.008) and pathologic node status (P = 0.003) was independently predictive of prognosis. alpha-sma 229-238 vimentin Homo sapiens 98-106 24850148-4 2014 Citrullinated vimentin is the target of anti-Sa antibodies, which are specific to rheumatoid arthritis, and play a critical role in the pathogenesis of the disease. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 45-47 vimentin Homo sapiens 14-22 23686305-10 2014 Although intracellular calcium chelation almost completely blocked the induction of many EMT markers, including vimentin, Twist and N-cadherin, the effect of TRPM7 silencing was specific for vimentin protein expression and STAT3 phosphorylation. Calcium 23-30 vimentin Homo sapiens 112-120 24612689-0 2014 Vimentin silencing effect on invasive and migration characteristics of doxorubicin resistant MCF-7 cells. Doxorubicin 71-82 vimentin Homo sapiens 0-8 24692728-7 2014 Furthermore, western blot analysis of proteins involved in EMT revealed that treatment with TDB resulted in the increase of E-cadherin and the decrease of vimentin and transcription factor SNAIL, indicating EMT suppression. TDB 92-95 vimentin Homo sapiens 155-163 24092501-0 2014 Functional relevance of D,L-sulforaphane-mediated induction of vimentin and plasminogen activator inhibitor-1 in human prostate cancer cells. sulforaphane 24-40 vimentin Homo sapiens 63-71 24447834-4 2014 We showed the expression of H4 receptors in NSCLC and found that 4-methylhistamine increased the expression of the epithelial marker E-cadherin and decreased the expression of Vimentin, the mesenchymal marker, in both NSCLC cell lines and xenograft NSCLC tumours. 4-methylhistamine 65-82 vimentin Homo sapiens 176-184 24612689-11 2014 The main purpose of this study was to investigate changes in invasive and migration characteristics of MCF-7/Dox cell line, after transient silencing of vimentin gene by specific siRNA. Doxorubicin 109-112 vimentin Homo sapiens 153-161 24478454-7 2014 The requirement for vimentin in repair cell function is revealed by both small interfering RNA vimentin knockdown and exposure to the vimentin-targeted drug withaferin A. withaferin A 157-169 vimentin Homo sapiens 20-28 24750186-6 2014 The relatively slow progression of DPAM may be attributable to the smaller number of SICs that lack E-cadherin expression and have increased vimentin expression, whereas the rapid progression of PMCA may be due to larger numbers of these SICs. dpam 35-39 vimentin Homo sapiens 141-149 24678619-4 2014 RESULTS: Decreased E-cadherin expression and increased vimentin and alpha-SMA expression induced by TGF-beta1 in alveolar epithelial cell (A549) were significantly abrogated by the non-selective mAChR antagonist atropine and enhanced by the acetylcholinesterase inhibitor physostigmine. Atropine 212-220 vimentin Homo sapiens 55-63 24678619-4 2014 RESULTS: Decreased E-cadherin expression and increased vimentin and alpha-SMA expression induced by TGF-beta1 in alveolar epithelial cell (A549) were significantly abrogated by the non-selective mAChR antagonist atropine and enhanced by the acetylcholinesterase inhibitor physostigmine. Physostigmine 272-285 vimentin Homo sapiens 55-63 24523904-10 2014 Interestingly, TAM decreased the expression of neural stem cell markers--Nestin, Bmi1, Vimentin, Sox2, and Musashi in HNGC-2 cell line and G1 cells implicating its potential as a stemness inhibiting drug. Tamoxifen 15-18 vimentin Homo sapiens 87-95 23996472-4 2014 We defined cell lines as calcitriol sensitive based on demonstrating an enhanced epithelial phenotype with increased E-cadherin, reduced vimentin and decreased expression of Snail and Slug as well as decreased cellular migration in response to calcitriol. Calcitriol 25-35 vimentin Homo sapiens 137-145 24297333-8 2014 Fisetin inhibited molecular changes associated with EMT induced by LMP1, upregulated the epithelial marker, E-cadherin protein, and downregulated the mesenchymal marker, vimentin protein, levels. fisetin 0-7 vimentin Homo sapiens 170-178 24328151-7 2014 Consistently, anethole upregulated E-cadherin and downregulated the expression of Vimentin, Twist and PI3K, and AKT at the protein level in DU145 cells. anethole 14-22 vimentin Homo sapiens 82-90 24075972-0 2014 N-Acetylglucosamine-conjugated block copolymer consisting of poly(ethylene oxide) and cationic polyaspartamide as a gene carrier for targeting vimentin-expressing cells. Acetylglucosamine 0-19 vimentin Homo sapiens 143-151 24456611-8 2014 Berberine inhibited invasion and migration of A549 cells, increased expression of the epithelial phenotype marker E-cadherin, repressed the expression of the mesenchymal phenotype marker Vimentin, as well as decreased the level of epithelial-to-mesenchymal -inducing transcription factors Snail1 and Slug during the initiation of TGF-beta1-induced epithelial-to-mesenchymal. Berberine 0-9 vimentin Homo sapiens 187-195 24075972-0 2014 N-Acetylglucosamine-conjugated block copolymer consisting of poly(ethylene oxide) and cationic polyaspartamide as a gene carrier for targeting vimentin-expressing cells. copolymer 37-46 vimentin Homo sapiens 143-151 24075972-0 2014 N-Acetylglucosamine-conjugated block copolymer consisting of poly(ethylene oxide) and cationic polyaspartamide as a gene carrier for targeting vimentin-expressing cells. poly 39-43 vimentin Homo sapiens 143-151 24075972-0 2014 N-Acetylglucosamine-conjugated block copolymer consisting of poly(ethylene oxide) and cationic polyaspartamide as a gene carrier for targeting vimentin-expressing cells. Ethylene Oxide 66-80 vimentin Homo sapiens 143-151 24075972-0 2014 N-Acetylglucosamine-conjugated block copolymer consisting of poly(ethylene oxide) and cationic polyaspartamide as a gene carrier for targeting vimentin-expressing cells. polyaspartamide 95-110 vimentin Homo sapiens 143-151 24075972-2 2014 Here, we synthesized a biocompatible block copolymer (abbreviated as PASPG) which consists of cationic poly[(aspartamide)(spermine)] for complexation with DNA and enhancing transfection efficiency due to buffering ability of spermine, poly(ethylene oxide)(PEO) for stability after systemic administration of the gene and N-acetylglucosamine (GlcNAc) as a specific ligand to target vimentin-expressing cells. copolymer 43-52 vimentin Homo sapiens 381-389 24075972-2 2014 Here, we synthesized a biocompatible block copolymer (abbreviated as PASPG) which consists of cationic poly[(aspartamide)(spermine)] for complexation with DNA and enhancing transfection efficiency due to buffering ability of spermine, poly(ethylene oxide)(PEO) for stability after systemic administration of the gene and N-acetylglucosamine (GlcNAc) as a specific ligand to target vimentin-expressing cells. paspg 69-74 vimentin Homo sapiens 381-389 24075972-2 2014 Here, we synthesized a biocompatible block copolymer (abbreviated as PASPG) which consists of cationic poly[(aspartamide)(spermine)] for complexation with DNA and enhancing transfection efficiency due to buffering ability of spermine, poly(ethylene oxide)(PEO) for stability after systemic administration of the gene and N-acetylglucosamine (GlcNAc) as a specific ligand to target vimentin-expressing cells. poly[(aspartamide) 103-121 vimentin Homo sapiens 381-389 24075972-2 2014 Here, we synthesized a biocompatible block copolymer (abbreviated as PASPG) which consists of cationic poly[(aspartamide)(spermine)] for complexation with DNA and enhancing transfection efficiency due to buffering ability of spermine, poly(ethylene oxide)(PEO) for stability after systemic administration of the gene and N-acetylglucosamine (GlcNAc) as a specific ligand to target vimentin-expressing cells. Spermine 122-131 vimentin Homo sapiens 381-389 24075972-2 2014 Here, we synthesized a biocompatible block copolymer (abbreviated as PASPG) which consists of cationic poly[(aspartamide)(spermine)] for complexation with DNA and enhancing transfection efficiency due to buffering ability of spermine, poly(ethylene oxide)(PEO) for stability after systemic administration of the gene and N-acetylglucosamine (GlcNAc) as a specific ligand to target vimentin-expressing cells. Spermine 122-130 vimentin Homo sapiens 381-389 24269590-5 2014 Furthermore, treatment with 50 muM EGCG inhibited high expression of vimentin and Slug in the cells at a leading edge of scratch. epigallocatechin gallate 35-39 vimentin Homo sapiens 69-77 24466036-11 2014 Furthermore, treatment of fisetin promoted mesenchymal to epithelial transition in melanoma cells, which was associated with a decrease in mesenchymal markers (N-cadherin, vimentin, snail and fibronectin) and an increase in epithelial markers (E-cadherin and desmoglein). fisetin 26-33 vimentin Homo sapiens 172-180 24236784-7 2013 Curcumin reversed doxorubicin-induced morphological changes, inhibited doxorubicin-induced downregulation of E-cadherin expressions, and inhibited doxorubicin-induced upregulation of vimentin expression. Curcumin 0-8 vimentin Homo sapiens 183-191 24812621-6 2014 Consistent with these results, alpha -mangostin decreased the expression of MMP-2, MMP-9, N-cadherin, and vimentin and increased the expression of E-cadherin. mangostin 31-47 vimentin Homo sapiens 106-114 25323856-0 2014 Tetrahydroxystilbene glucoside protects against oxidized LDL-induced endothelial dysfunction via regulating vimentin cytoskeleton and its colocalization with ICAM-1 and VCAM-1. 2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside 0-30 vimentin Homo sapiens 108-116 24890158-9 2014 To further study this mechanism, RT-PCR analysis showed that vimentin, MMP2 and CXCR4 mRNA levels were more highly expressed in the lung cancer cells after co-culture, but did not obviously decrease compared with the control cells following gefitinib treatment. Gefitinib 241-250 vimentin Homo sapiens 61-69 24075972-5 2014 Furthermore, PASPG showed higher transfection efficiency in vimentin-expressing cells than vimentin-deficient ones due to the recognition of GlcNAc in the polymeric gene carrier by vimentin in the cells for the receptor-mediated endocytosis of PASPG. Acetylglucosamine 141-147 vimentin Homo sapiens 60-68 24075972-5 2014 Furthermore, PASPG showed higher transfection efficiency in vimentin-expressing cells than vimentin-deficient ones due to the recognition of GlcNAc in the polymeric gene carrier by vimentin in the cells for the receptor-mediated endocytosis of PASPG. Acetylglucosamine 141-147 vimentin Homo sapiens 91-99 24075972-5 2014 Furthermore, PASPG showed higher transfection efficiency in vimentin-expressing cells than vimentin-deficient ones due to the recognition of GlcNAc in the polymeric gene carrier by vimentin in the cells for the receptor-mediated endocytosis of PASPG. Acetylglucosamine 141-147 vimentin Homo sapiens 91-99 24075972-7 2014 This study reveals that GlcNAc-coupled biocompatible block copolymer can specifically deliver gene to vimentin-expressing cells. Acetylglucosamine 24-30 vimentin Homo sapiens 102-110 24075972-7 2014 This study reveals that GlcNAc-coupled biocompatible block copolymer can specifically deliver gene to vimentin-expressing cells. copolymer 59-68 vimentin Homo sapiens 102-110 24741593-6 2014 These findings suggest that in sera from patients with SN-APS, antibodies may be detected using "new" antigenic targets (mainly vimentin/cardiolipin) or methodological approaches different from traditional techniques (mainly TLC immunostaining). sn-aps 55-61 vimentin Homo sapiens 128-136 24173124-9 2014 DFX-treated cells expressed E-cadherin and plakoglobin at a higher level, and vimentin and N-cadherin at a lower level, when compared with these levels in control cells. Deferoxamine 0-3 vimentin Homo sapiens 78-86 24405590-9 2014 Additionally, compared with the 253J cells, 253J/DOX cells presented the upregulation of E-cadherin, the downregulation of vimentin and the inhibition of migration ability. Doxorubicin 49-52 vimentin Homo sapiens 123-131 23975649-14 2013 CONCLUSIONS: VIM DBS may reduce severe, disabling tremor in patients with MS. dibromsalan 17-20 vimentin Homo sapiens 13-16 24012496-5 2013 Mechanistically, silibinin could inhibit glycogen synthase kinase-3beta (GSK3beta) phosphorylation, beta-catenin nuclear translocation and transactivation, and ZEB1 gene transcription that subsequently regulated the expression of cytokeratins, vimentin and matrix metalloproteinase-2 (MMP2) to reverse epithelial-mesenchymal transition (EMT). Silybin 17-26 vimentin Homo sapiens 244-252 23993685-10 2013 Suppression of vimentin in H2228/CR cells by siRNA treatment restored sensitivity to crizotinib. Crizotinib 85-95 vimentin Homo sapiens 15-23 24032550-9 2013 Compared with the negative controls, expressions of cytokeratin 7 and ERbeta proteins were elevated while fibronectin and vimentin levels in ovarian tissues were downregulated in the OSE-like cell transplantation group. serine O-sulfate 183-186 vimentin Homo sapiens 122-130 23954421-3 2013 Hence, we have investigated the changes in drug profile, affinity and binding stability of meropenem with clinically important MBLs viz., IMP, VIM and NDM during the course of molecular evolution. Meropenem 91-100 vimentin Homo sapiens 143-146 23954421-7 2013 In all the trajectories, we had found an increase in mouth opening/solvent accessible volume/area of the catalytic pocket and decrease in Gibbs" free energy (DeltaG ) for binding with meropenem and Michealis-Menten constant (Km) - indicating an increase in choice of drugs, binding stability and meropenem affinity from primitive to advanced MBL variants, with exceptions of IMP-20, IMP-26, VIM-13 and VIM-18 which might be due to sign epistasis. Meropenem 184-193 vimentin Homo sapiens 391-394 23954421-7 2013 In all the trajectories, we had found an increase in mouth opening/solvent accessible volume/area of the catalytic pocket and decrease in Gibbs" free energy (DeltaG ) for binding with meropenem and Michealis-Menten constant (Km) - indicating an increase in choice of drugs, binding stability and meropenem affinity from primitive to advanced MBL variants, with exceptions of IMP-20, IMP-26, VIM-13 and VIM-18 which might be due to sign epistasis. Meropenem 184-193 vimentin Homo sapiens 402-405 23954421-7 2013 In all the trajectories, we had found an increase in mouth opening/solvent accessible volume/area of the catalytic pocket and decrease in Gibbs" free energy (DeltaG ) for binding with meropenem and Michealis-Menten constant (Km) - indicating an increase in choice of drugs, binding stability and meropenem affinity from primitive to advanced MBL variants, with exceptions of IMP-20, IMP-26, VIM-13 and VIM-18 which might be due to sign epistasis. Meropenem 296-305 vimentin Homo sapiens 391-394 23954421-7 2013 In all the trajectories, we had found an increase in mouth opening/solvent accessible volume/area of the catalytic pocket and decrease in Gibbs" free energy (DeltaG ) for binding with meropenem and Michealis-Menten constant (Km) - indicating an increase in choice of drugs, binding stability and meropenem affinity from primitive to advanced MBL variants, with exceptions of IMP-20, IMP-26, VIM-13 and VIM-18 which might be due to sign epistasis. Meropenem 296-305 vimentin Homo sapiens 402-405 24282534-5 2013 Vimentin was phosphorylated at Ser459, by DNA-PK, in cells transfected with Dbait32Hc. dbait32hc 76-85 vimentin Homo sapiens 0-8 24113073-2 2013 MAIN METHODS: Using static cell adhesion assays to determine the effect of various times and duration of LNAC (10mM) treatment on IR (20Gy)-altered adhesive affinity between MDA-MB-231 breast cancer cells and ECM, especially fibronectin; using fluorescence dye carboxy- 2,7-dichlorodihydrofluorescein diacetate to determine intracellular levels of ROS; using flow cytometry to determine cell surface integrin beta1; and using Western blot analysis to determine vimentin expression. N-acetylcysteine lysinate 105-109 vimentin Homo sapiens 461-469 24113073-6 2013 In addition to cell adhesion, treatment with LNAC inhibited IR-induced expression of vimentin, an epithelial-mesenchymal transition marker (EMT). N-acetylcysteine lysinate 45-49 vimentin Homo sapiens 85-93 24282534-7 2013 In migratory cells, the vimentin phosphorylation induced by Dbait32Hc was associated with a lower cellular adhesion and migration capacity. dbait32hc 60-69 vimentin Homo sapiens 24-32 24244418-3 2013 As little as 30 min of RPM exposure resulted in increased expression of several genes responsible for cell motility, structure and integrity (beta-actin); control of cell growth, cell proliferation, cell differentiation and apoptosis (TGF-beta1, osteopontin); and cytoskeletal components such as microtubules (beta-tubulin) and intermediate filaments (vimentin). Sirolimus 23-26 vimentin Homo sapiens 352-360 24244418-4 2013 After 4 hours of RPM exposure disruptions in the vimentin network were detected. Sirolimus 17-20 vimentin Homo sapiens 49-57 23764119-2 2013 METHODS: The effect of silibinin on the expression of alpha-smooth muscle actin (alpha-SMA) and vimentin in response to transforming growth factor-beta1 (TGF-beta1) was determined in human tenon fibroblasts (HTFs). Silybin 23-32 vimentin Homo sapiens 96-104 24179501-5 2013 The AKT inhibitor, GSK690693, inhibited AKT, blocked the expression of ZEB1 and vimentin and restored the expression of E-cadherin following IR, thus preventing the migration and EMT of the tumor cells. GSK690693 19-28 vimentin Homo sapiens 80-88 24217116-6 2013 Further, we discovered that 1,25(OH)2D3 induces E-cadherin and decreases EMT-related molecules SNAIL, ZEB1, and vimentin in NSCLC cells. Calcitriol 28-39 vimentin Homo sapiens 112-120 24005669-8 2013 Because RACK1 and vimentin were both up-regulated with sphingosine 1-phosphate treatment, required for invasion, and regulated FAK, we tested whether they complexed together. sphingosine 1-phosphate 55-78 vimentin Homo sapiens 18-26 24005669-10 2013 In addition, RACK1, vimentin, and FAK formed an intermolecular complex in invading endothelial cultures in three dimensions in response to stimulation by sphingosine 1-phosphate and growth factors. sphingosine 1-phosphate 154-177 vimentin Homo sapiens 20-28 24507098-9 2013 HMB45, Melan A, S-100 and vimentin were expressed in the melanin containing cells in 4, 4, 5 and 7 cases, respectively. Melanins 57-64 vimentin Homo sapiens 26-34 23974215-5 2013 Upon (32)P-labeling and vimentin immunoprecipitation, increased phosphorylation of vimentin was observed in MCP-1 treated monocytes as compared to the untreated monocytes. Phosphorus-32 5-10 vimentin Homo sapiens 83-91 23974215-12 2013 Taken together our findings suggest that inhibition of PKCbeta regulates vimentin secretion and, thereby, its interaction with Dectin-1 and downstream stimulation of superoxide anion production. Superoxides 166-182 vimentin Homo sapiens 73-81 24167634-6 2013 Moreover, the continuous exposure to gefitinib prevented the epithelial-mesenchymal transition (EMT) with increased E-cadherin expression and down-regulation of vimentin and N-cadherin. Gefitinib 37-46 vimentin Homo sapiens 161-169 23704778-11 2013 Flow cytometric analyses also demonstrated an increase in vimentin and twist expression in letrozole-resistance cells, suggesting an onset of epithelial to mesenchymal transition (EMT). Letrozole 91-100 vimentin Homo sapiens 58-66 24138806-9 2013 Worthy of note treatment with polydatin induced a nuclear localization and decreased expression of heat shock protein 27, and vimentin redistributed within the cell. polydatin 30-39 vimentin Homo sapiens 126-134 24011086-11 2013 Moreover, dimethyl fumarate, a NF-kappaB inhibitor, inhibited RANKL-induced EMT, cell migration, and invasion, and upregulated the expressions of Snail, Twist, vimentin, and N-cadherin. Dimethyl Fumarate 10-27 vimentin Homo sapiens 160-168 24093956-9 2013 LBH589 inhibited metastasis in vitro via down-regulation of N-cadherin, vimentin, TWIST1, VEGF and up-regulation of E-cadherin. Panobinostat 0-6 vimentin Homo sapiens 72-80 24241171-4 2013 Also, the fusion peptides Vim- TBS (58-81)-p10 & Tat (48-60)-p10 were studied using molecular mechanics (MM) and molecular dynamics (MD) based strategies. Adenosine Monophosphate 48-51 vimentin Homo sapiens 26-29 23824089-8 2013 Finally, blocking of NF-kappaB with Bay11-7082 prevented CSE-induced EMT and malignant transformation due to decreases of E-cadherin and miR-200c and elevations of IL-6, N-cadherin, and vimentin. 3-(4-methylphenylsulfonyl)-2-propenenitrile 36-46 vimentin Homo sapiens 186-194 24378092-9 2013 In the presence of afatinib, HGF up-regulated the expression of vimentin and down-regulated the expression of E-cadherin. Afatinib 19-27 vimentin Homo sapiens 64-72 24073199-6 2013 Further analysis revealed that the vimentin in the virus factories was serine-82 phosphorylated. Serine 71-77 vimentin Homo sapiens 35-43 24073199-7 2013 More importantly, EV71 VP1 protein is responsible for the activation of calmodulin-dependent protein kinase II (CaMK-II) which phosphorylated the N-terminal domain of vimentin on serine 82. Serine 179-185 vimentin Homo sapiens 167-175 24069380-2 2013 Withaniasomnifera root extracts (WRE) have anti-proliferative activity and the active component, Withaferin A, inhibits the pro-metastatic protein, vimentin. withaferin A 97-109 vimentin Homo sapiens 148-156 24020840-11 2013 Furthermore, the expression of vimentin in both the parietal and visceral peritoneum after 21 days was significantly lower in the icodextrin group than in the sodium chloride group (p = 0.038 and p = 0.028, respectively). Icodextrin 130-140 vimentin Homo sapiens 31-39 24020840-11 2013 Furthermore, the expression of vimentin in both the parietal and visceral peritoneum after 21 days was significantly lower in the icodextrin group than in the sodium chloride group (p = 0.038 and p = 0.028, respectively). Sodium Chloride 159-174 vimentin Homo sapiens 31-39 23674515-10 2013 Further data revealed that vimentin induces O2- production by human monocytes. Superoxides 44-46 vimentin Homo sapiens 27-35 23543349-5 2013 Citrullinated (Cit) and native peptides of Vimentin and Aggrecan were used for stimulating peripheral blood mononuclear cells in 5-day cultures. cit 0-3 vimentin Homo sapiens 43-51 23674515-12 2013 Vimentin also co-localized with Dectin-1 in macrophage-rich regions where O2- is produced. Superoxides 74-77 vimentin Homo sapiens 0-8 23674515-14 2013 Its presence in areas of artery wall inflammation and O2- production suggests that vimentin activates Dectin-1 and contributes to the oxidation of lipids and cholesterol accumulation in atherosclerosis. Superoxides 54-56 vimentin Homo sapiens 83-91 23674515-14 2013 Its presence in areas of artery wall inflammation and O2- production suggests that vimentin activates Dectin-1 and contributes to the oxidation of lipids and cholesterol accumulation in atherosclerosis. Cholesterol 158-169 vimentin Homo sapiens 83-91 24325063-6 2013 RESULTS: Compared with the normal control group, the proliferation and migration of HepG2 cells under CoCl2-induced hypoxia significantly increased, the expression of HIF-1alpha was up-regulated, and the expression of E-cadherin protein was obviously down-regulated, and the expression of vimentin significantly increased (all P < 0.05). cobaltous chloride 102-107 vimentin Homo sapiens 289-297 23981606-13 2013 After induction of TAM resistance, qRT-PCR indicated that MCF7 cells expressed increased mRNA levels of Snail, vimentin, and N-cadherin and decreased levels of E-cadherin, which are considered as EMT characteristics (P < 0.05). Tamoxifen 19-22 vimentin Homo sapiens 111-119 24325063-7 2013 Intervention by curcumin significantly inhibited the proliferation and migration of hypoxic HepG2 cells, and expressions of HIF-1alpha and vimentin decreased, and the expression of E-cadherin was up-regulated, showing statistical difference when compared with those of the CoCl2 group (P < 0.05). Curcumin 16-24 vimentin Homo sapiens 139-147 23716625-6 2013 In vitro-cultured human corneal stromal cells were treated with 0 to 500 nM rapamycin for 3 days and then assessed by immunofluorescence staining of vimentin and alpha-smooth muscle actin (alpha-SMA). Sirolimus 76-85 vimentin Homo sapiens 149-157 23887631-9 2013 Nine stemness-linked genes (ABCB1, ABCC4, LMO2, SOX2, ERCC5, S100A10, IGFBP3, TCF3, and VIM) were downregulated in vorinostat-treated doxorubicin-resistant SK-N-Be(2)C cells relative to doxorubicin-resistant cells. Vorinostat 115-125 vimentin Homo sapiens 88-91 23541792-10 2013 In response to exogenously added 25-OHC, THP-1 cells reorganized intermediate filament-associated vimentin to more cortical and polarized structures. 25-hydroxycholesterol 33-39 vimentin Homo sapiens 98-106 23874579-6 2013 Interestingly, 2D western blot analysis revealed that the forms of vimentin are regulated independently of each other under glucose and NaCl osmotic stress. Glucose 124-131 vimentin Homo sapiens 67-75 23874579-6 2013 Interestingly, 2D western blot analysis revealed that the forms of vimentin are regulated independently of each other under glucose and NaCl osmotic stress. Sodium Chloride 136-140 vimentin Homo sapiens 67-75 23874579-7 2013 Renal cells, adapted to high NaCl osmotic stress, express a high level of VIM IV (the form with the highest molecular weight), besides the three other forms, and exhibit higher resistance to apoptotic induction with TNF-alpha or staurosporin compared to the control. Staurosporine 229-241 vimentin Homo sapiens 74-77 26770672-3 2013 Curcumin activated caspase-3 and the cleavage of the two cytoskeletal proteins lamin B1 and vimentin. Curcumin 0-8 vimentin Homo sapiens 92-100 23448354-10 2013 The CAFs showed positive staining for vimentin, alpha-smooth muscle actin (alpha-SMA), and fibroblast activation protein (FAP). cafs 4-8 vimentin Homo sapiens 38-46 23895702-9 2013 Incubation of human BEC with silica induced de novo expression of alpha-SMA and Vim, and loss of E-cad. Silicon Dioxide 29-35 vimentin Homo sapiens 80-83 23895702-11 2013 Y27632 up-regulated the E-cad expression but attenuated alpha-SMA and Vim expression in silica-stimulated cells. Silicon Dioxide 88-94 vimentin Homo sapiens 70-73 23504987-7 2013 Mechanistically, pterostilbene suppressed NFkappaB, Twist1, vimentin, and increased E-cadherin expression. pterostilbene 17-30 vimentin Homo sapiens 60-68 23611688-12 2013 We propose that the patients with DT with a mild dystonia should be considered for Vim DBS procedure and the coexistence of severe DT and dystonia may be successfully controlled by combined GPi and Vim DBS surgeries. dibromsalan 87-90 vimentin Homo sapiens 83-86 23611688-12 2013 We propose that the patients with DT with a mild dystonia should be considered for Vim DBS procedure and the coexistence of severe DT and dystonia may be successfully controlled by combined GPi and Vim DBS surgeries. Thymidine 131-133 vimentin Homo sapiens 198-201 23611688-12 2013 We propose that the patients with DT with a mild dystonia should be considered for Vim DBS procedure and the coexistence of severe DT and dystonia may be successfully controlled by combined GPi and Vim DBS surgeries. dibromsalan 202-205 vimentin Homo sapiens 198-201 24061457-0 2013 Expression of vimentin in breast carcinoma, its correlation with Ki67 and other histopathological parameters. ki67 65-69 vimentin Homo sapiens 14-22 23752129-9 2013 Our results showed that coculture with M2-polarized TAMs increased fibroblastic morphology, upregulated mesenchymal markers vimentin and snail at the mRNA and protein levels, and increased proliferation, migration, and metalloproteinase (MMP)2 and MMP9 proteolytic activity in pancreatic cancer cells. tams 52-56 vimentin Homo sapiens 124-132 23611688-7 2013 Vim was targeted in four patients and three had unilateral procedure and one bilateral Vim DBS. dibromsalan 91-94 vimentin Homo sapiens 0-3 23611688-7 2013 Vim was targeted in four patients and three had unilateral procedure and one bilateral Vim DBS. dibromsalan 91-94 vimentin Homo sapiens 87-90 23611688-10 2013 The best results for tremor control were observed in patients with Vim DBS but they had persisting mild dystonia. dibromsalan 71-74 vimentin Homo sapiens 67-70 23611688-12 2013 We propose that the patients with DT with a mild dystonia should be considered for Vim DBS procedure and the coexistence of severe DT and dystonia may be successfully controlled by combined GPi and Vim DBS surgeries. Thymidine 34-36 vimentin Homo sapiens 83-86 23785446-12 2013 Triol treatment caused increased expression of E-cadherin protein levels but decreased expression of N-cadherin, vimentin, Slug, FAK, phospho-FAK Ser722, and phospho-FAK Tyr861 protein levels. Calcitriol 0-5 vimentin Homo sapiens 113-121 23511428-5 2013 In addition, after treatment with UA, the A549 cells showed decreased expression of astrocyte-elevated gene-1 (AEG-1) accompanied by upregulation of E-cadherin and downregulation of N-cadherin and vimentin, which have been reported to characterize the epithelial-mesenchymal transition (EMT). ursolic acid 34-36 vimentin Homo sapiens 197-205 23511428-6 2013 Further results also confirmed that the expression of vimentin was decreased by the siRNA technique to directly knock down AEG-1 expression, indicating that AEG-1 was involved in UA-mediated EMT inhibition. ursolic acid 179-181 vimentin Homo sapiens 54-62 21544924-6 2013 Morphologically, both PCB 153 and PFOS induced changes in the vimentin and actin filaments in the Sertoli cells, as investigated using confocal argon ion laser scanning microscopy; here, PFOS exhibited a more dramatic effect than did PCB 153. perfluorooctane sulfonic acid 187-191 vimentin Homo sapiens 62-70 23500768-5 2013 Compared with the control group, the astaxanthin-treated groups exhibited downregulated protein expressions of alpha-smooth muscle actin, vimentin, hydroxyproline, and B cell lymphoma/leukemia-2 as well as upregulated protein expressions of E-cadherin and p53 in vitro and in vivo. astaxanthine 37-48 vimentin Homo sapiens 138-146 23518002-5 2013 The results showed that Cr(VI) at low doses represses E-cadherin mRNA and protein expression, enhances mesenchymal marker vimentin expression and transforms the epithelial cell into fibroblastoid morphology. chromium hexavalent ion 24-30 vimentin Homo sapiens 122-130 23563640-8 2013 The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P<0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P<0.01, respectively). Curcumin 93-101 vimentin Homo sapiens 279-287 23563640-8 2013 The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P<0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P<0.01, respectively). Curcumin 93-101 vimentin Homo sapiens 279-287 23482564-0 2013 Selective inhibition of human group IIA-secreted phospholipase A2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes. Arachidonic Acid 92-108 vimentin Homo sapiens 166-174 23482564-5 2013 This study provides structural and pharmacological evidence for an association between vimentin, hGIIA, and arachidonic acid metabolism in synovial inflammation, avenues for selective interrogation of hGIIA signaling, and new strategies for therapeutic hGIIA inhibitor design. Arachidonic Acid 108-124 vimentin Homo sapiens 87-95 22684479-8 2013 Use of WFA demonstrated that vimentin was required for NOD2-dependent NF-kappaB activation and muramyl dipeptide-induced autophagy induction, and that NOD2 and vimentin regulated the invasion and survival properties of a CD-associated adherent-invasive Escherichia coli strain. Dipeptides 103-112 vimentin Homo sapiens 29-37 21544924-6 2013 Morphologically, both PCB 153 and PFOS induced changes in the vimentin and actin filaments in the Sertoli cells, as investigated using confocal argon ion laser scanning microscopy; here, PFOS exhibited a more dramatic effect than did PCB 153. 2,2',4,4',5,5'-Hexachlorobiphenyl 22-29 vimentin Homo sapiens 62-70 21544924-6 2013 Morphologically, both PCB 153 and PFOS induced changes in the vimentin and actin filaments in the Sertoli cells, as investigated using confocal argon ion laser scanning microscopy; here, PFOS exhibited a more dramatic effect than did PCB 153. perfluorooctane sulfonic acid 34-38 vimentin Homo sapiens 62-70 23357373-6 2013 In contrast, in MG-63 and OHS-4 cells dense microtubule and vimentin networks seem to facilitate some nuclear deformation even in the absence of a prominent actin cytoskeleton. Magnesium 16-18 vimentin Homo sapiens 60-68 23536634-7 2013 The reactivity to N-terminal vimentin of IgG FL Igs was significantly higher than that of IgM FL Igs (30.4 versus 10%; p = 0.0022). Nitrogen 18-19 vimentin Homo sapiens 29-37 23357373-6 2013 In contrast, in MG-63 and OHS-4 cells dense microtubule and vimentin networks seem to facilitate some nuclear deformation even in the absence of a prominent actin cytoskeleton. hydroxide ion 26-29 vimentin Homo sapiens 60-68 23621814-6 2013 Immunohistochemically, TCs expressed vimentin, CD34 and occasionally c-kit/CD117. Technetium 23-26 vimentin Homo sapiens 37-45 22795529-0 2013 Detection of vimentin serine phosphorylation by multicolor Quenchbodies. Serine 22-28 vimentin Homo sapiens 13-21 22422628-7 2013 The migration ability of head and neck cancer-derived sphere cells was lessened under quercetin treatment partially due to the decreased productions of Twist, N-cadherin, and vimentin. Quercetin 86-95 vimentin Homo sapiens 175-183 23401150-3 2013 Emerging reports suggest good response to DBS of the internal globus pallidus (GPi) and ventral intermediate nucleus (VIM) of the thalamus. dibromsalan 42-45 vimentin Homo sapiens 118-121 22795529-2 2013 Vimentin, the most abundant intermediate filament protein, is phosphorylated at its specific serine (Ser) residues in a cell cycle dependent manner. Serine 93-99 vimentin Homo sapiens 0-8 22795529-2 2013 Vimentin, the most abundant intermediate filament protein, is phosphorylated at its specific serine (Ser) residues in a cell cycle dependent manner. Serine 101-104 vimentin Homo sapiens 0-8 22795529-4 2013 Here we present the detection of the vimentin Ser71 phosphorylation (PS71) and the vimentin Ser82 phosphorylation (PS82) using a novel fluorescent biosensor Quenchbody, which works on the principle of antigen-dependent removal of a quenching effect by intrinsic tryptophan residues on a carboxytetramethylrhodamine (TAMRA) dye incorporated at the N-terminal region of single chain antibody variable region. Tryptophan 262-272 vimentin Homo sapiens 37-45 22795529-4 2013 Here we present the detection of the vimentin Ser71 phosphorylation (PS71) and the vimentin Ser82 phosphorylation (PS82) using a novel fluorescent biosensor Quenchbody, which works on the principle of antigen-dependent removal of a quenching effect by intrinsic tryptophan residues on a carboxytetramethylrhodamine (TAMRA) dye incorporated at the N-terminal region of single chain antibody variable region. Tryptophan 262-272 vimentin Homo sapiens 83-91 22795529-4 2013 Here we present the detection of the vimentin Ser71 phosphorylation (PS71) and the vimentin Ser82 phosphorylation (PS82) using a novel fluorescent biosensor Quenchbody, which works on the principle of antigen-dependent removal of a quenching effect by intrinsic tryptophan residues on a carboxytetramethylrhodamine (TAMRA) dye incorporated at the N-terminal region of single chain antibody variable region. carboxytetramethylrhodamine 287-314 vimentin Homo sapiens 37-45 22795529-4 2013 Here we present the detection of the vimentin Ser71 phosphorylation (PS71) and the vimentin Ser82 phosphorylation (PS82) using a novel fluorescent biosensor Quenchbody, which works on the principle of antigen-dependent removal of a quenching effect by intrinsic tryptophan residues on a carboxytetramethylrhodamine (TAMRA) dye incorporated at the N-terminal region of single chain antibody variable region. carboxytetramethylrhodamine 287-314 vimentin Homo sapiens 83-91 22795529-4 2013 Here we present the detection of the vimentin Ser71 phosphorylation (PS71) and the vimentin Ser82 phosphorylation (PS82) using a novel fluorescent biosensor Quenchbody, which works on the principle of antigen-dependent removal of a quenching effect by intrinsic tryptophan residues on a carboxytetramethylrhodamine (TAMRA) dye incorporated at the N-terminal region of single chain antibody variable region. tamra 316-321 vimentin Homo sapiens 37-45 22795529-4 2013 Here we present the detection of the vimentin Ser71 phosphorylation (PS71) and the vimentin Ser82 phosphorylation (PS82) using a novel fluorescent biosensor Quenchbody, which works on the principle of antigen-dependent removal of a quenching effect by intrinsic tryptophan residues on a carboxytetramethylrhodamine (TAMRA) dye incorporated at the N-terminal region of single chain antibody variable region. tamra 316-321 vimentin Homo sapiens 83-91 23992306-4 2013 The results showed that resveratrol not only inhibited cell proliferation, migration, and invasion in a dose-dependent manner, but also mediated the expression of EMT-related genes (E-cadherin, N-cadherin, vimentin, MMP-2, and MMP-9) which are important for cancer cellular motility, invasiveness and metastasis during tumorigenesis. Resveratrol 24-35 vimentin Homo sapiens 206-214 23165896-9 2013 Rather, mpICs display autoantigens vimentin and fibrinogen, and recognition of these targets by anti-citrullinated peptide antibodies contributes to the production of mpICs. mpics 8-13 vimentin Homo sapiens 35-43 23146760-9 2013 Our results show that 20 muM resveratrol increases expression of the epithelial phenotype marker E-cadherin and represses the expression of the mesenchymal phenotype markers, Fibronectin and Vimentin during the initiation of TGF-beta1-induced EMT. Resveratrol 29-40 vimentin Homo sapiens 191-199 23886156-6 2013 Treatment of HMM cells with H2O2 promoted EMT, as indicated by increased expression levels of vimentin, SLUG and TWIST1, and decreased E-cadherin expression. Hydrogen Peroxide 28-32 vimentin Homo sapiens 94-102 23812394-10 2013 Results showed that high glucose levels induced morphological changes, reduced E-cadherin expression (-73%), increased expression of vimentin (+148%) and alpha-SMA (+226%), increased TGF-beta1 (from 116.0+-5.2 microg/g to 351.0+-3.2 microg/g) and CTGF (from 0.26+-0.01 to 0.92+-0.03) secretion, and increased RhoA and ROCK activation (p<0.05 for all). Glucose 25-32 vimentin Homo sapiens 133-141 23206234-6 2013 TCs in primary mammary gland stromal cells with long and thin overlapping cytoplasmic processes, expressed c-kit/CD117, CD34 and vimentin in reconstitute breast cancer tissue. Technetium 0-3 vimentin Homo sapiens 129-137 23662124-9 2013 The overexpression of vimentin was attenuated by CAPE, and the alteration in morphology from polygonal to spindle shape was partially reversed by CAPE. caffeic acid phenethyl ester 49-53 vimentin Homo sapiens 22-30 23662124-9 2013 The overexpression of vimentin was attenuated by CAPE, and the alteration in morphology from polygonal to spindle shape was partially reversed by CAPE. caffeic acid phenethyl ester 146-150 vimentin Homo sapiens 22-30 23662124-14 2013 CAPE could inhibit the orthotopic growth and EMT of pancreatic cancer PANC-1 cells accompanied by downregulation of vimentin and Twist 2 expression. caffeic acid phenethyl ester 0-4 vimentin Homo sapiens 116-124 23128467-5 2013 Confocal microscopic data revealed that doxorubicin induces reorganization of cytoskeletal proteins including actin, tubulin and vimentin. Doxorubicin 40-51 vimentin Homo sapiens 141-149 22945917-7 2013 CONCLUSIONS: ME1071 reduced the MICs of carbapenems for bacteria with NDM-1 enzyme though synergy was weaker than for bacteria with IMP and VIM metallo-enzymes; this correlated with ME1071 having weaker affinity for NDM-1 than IMP-1 and VIM-2. Carbapenems 40-51 vimentin Homo sapiens 140-143 22765310-2 2012 METHOD: Human native Vim was citrullinated with rabbit PAD in vitro and detected using a Western blot assay with anti-modified citrulline antibody (anti-MC Ab). Citrulline 127-137 vimentin Homo sapiens 21-24 23682784-0 2013 In vitro and in vivo effects of phenethyl isothiocyanate treatment on vimentin protein expression in cancer cells. phenethyl isothiocyanate 32-56 vimentin Homo sapiens 70-78 23682784-2 2013 Because suppression of E-cadherin protein concomitant with induction of mesenchymal markers (e.g., vimentin) is a biochemical hallmark of epithelial-mesenchymal transition, a process implicated in cancer metastasis, we hypothesized that PEITC treatment was likely to suppress vimentin protein expression. phenethyl isothiocyanate 237-242 vimentin Homo sapiens 99-107 23682784-4 2013 RNA interference of vimentin resulted in a modest augmentation of PEITC-mediated inhibition of MDA-MB-231 and PC-3 cell migration as well as cell viability. phenethyl isothiocyanate 66-71 vimentin Homo sapiens 20-28 23022583-5 2012 SAHA treatment induced cofilin phosphorylation at Ser3, an increase in vimentin and paxillin expression and a decrease in stathmin expression as confirmed by western-blotting and immunofluorescence microscopy. Vorinostat 0-4 vimentin Homo sapiens 71-79 23682426-11 2012 We also found that berberine-induced apoptosis was associated with an upregulated expressions of p53 and prohibitin (PHB), and decreased vimentin expression. Berberine 19-28 vimentin Homo sapiens 137-145 22846177-2 2012 Vimentin binds to multivalent N-acetylglucosamine (GlcNAc) molecules at the cell surface and interacts with O-linked beta-GlcNAc proteins. Acetylglucosamine 30-49 vimentin Homo sapiens 0-8 22846177-2 2012 Vimentin binds to multivalent N-acetylglucosamine (GlcNAc) molecules at the cell surface and interacts with O-linked beta-GlcNAc proteins. Acetylglucosamine 51-57 vimentin Homo sapiens 0-8 22846177-2 2012 Vimentin binds to multivalent N-acetylglucosamine (GlcNAc) molecules at the cell surface and interacts with O-linked beta-GlcNAc proteins. o-linked beta-glcnac 108-128 vimentin Homo sapiens 0-8 22846177-4 2012 Here, we show that vimentin was altered by its interaction with GlcNAc-bearing molecules such as GlcNAc-bearing polymers. Acetylglucosamine 64-70 vimentin Homo sapiens 19-27 22846177-4 2012 Here, we show that vimentin was altered by its interaction with GlcNAc-bearing molecules such as GlcNAc-bearing polymers. Acetylglucosamine 97-103 vimentin Homo sapiens 19-27 22846177-4 2012 Here, we show that vimentin was altered by its interaction with GlcNAc-bearing molecules such as GlcNAc-bearing polymers. Polymers 112-120 vimentin Homo sapiens 19-27 22846177-5 2012 The interaction with GlcNAc-bearing polymers promoted the cell surface recruitment of vimentin followed by the phosphorylation of vimentin serine 71 and the increase in tetrameric vimentin disassembled from vimentin filaments in HeLa cells. Acetylglucosamine 21-27 vimentin Homo sapiens 86-94 22846177-5 2012 The interaction with GlcNAc-bearing polymers promoted the cell surface recruitment of vimentin followed by the phosphorylation of vimentin serine 71 and the increase in tetrameric vimentin disassembled from vimentin filaments in HeLa cells. Acetylglucosamine 21-27 vimentin Homo sapiens 130-138 22846177-5 2012 The interaction with GlcNAc-bearing polymers promoted the cell surface recruitment of vimentin followed by the phosphorylation of vimentin serine 71 and the increase in tetrameric vimentin disassembled from vimentin filaments in HeLa cells. Acetylglucosamine 21-27 vimentin Homo sapiens 130-138 22846177-5 2012 The interaction with GlcNAc-bearing polymers promoted the cell surface recruitment of vimentin followed by the phosphorylation of vimentin serine 71 and the increase in tetrameric vimentin disassembled from vimentin filaments in HeLa cells. Acetylglucosamine 21-27 vimentin Homo sapiens 130-138 22846177-5 2012 The interaction with GlcNAc-bearing polymers promoted the cell surface recruitment of vimentin followed by the phosphorylation of vimentin serine 71 and the increase in tetrameric vimentin disassembled from vimentin filaments in HeLa cells. Polymers 36-44 vimentin Homo sapiens 86-94 22846177-5 2012 The interaction with GlcNAc-bearing polymers promoted the cell surface recruitment of vimentin followed by the phosphorylation of vimentin serine 71 and the increase in tetrameric vimentin disassembled from vimentin filaments in HeLa cells. Polymers 36-44 vimentin Homo sapiens 130-138 22846177-5 2012 The interaction with GlcNAc-bearing polymers promoted the cell surface recruitment of vimentin followed by the phosphorylation of vimentin serine 71 and the increase in tetrameric vimentin disassembled from vimentin filaments in HeLa cells. Polymers 36-44 vimentin Homo sapiens 130-138 22846177-5 2012 The interaction with GlcNAc-bearing polymers promoted the cell surface recruitment of vimentin followed by the phosphorylation of vimentin serine 71 and the increase in tetrameric vimentin disassembled from vimentin filaments in HeLa cells. Polymers 36-44 vimentin Homo sapiens 130-138 22846177-5 2012 The interaction with GlcNAc-bearing polymers promoted the cell surface recruitment of vimentin followed by the phosphorylation of vimentin serine 71 and the increase in tetrameric vimentin disassembled from vimentin filaments in HeLa cells. Serine 139-145 vimentin Homo sapiens 86-94 22846177-5 2012 The interaction with GlcNAc-bearing polymers promoted the cell surface recruitment of vimentin followed by the phosphorylation of vimentin serine 71 and the increase in tetrameric vimentin disassembled from vimentin filaments in HeLa cells. Serine 139-145 vimentin Homo sapiens 130-138 22846177-5 2012 The interaction with GlcNAc-bearing polymers promoted the cell surface recruitment of vimentin followed by the phosphorylation of vimentin serine 71 and the increase in tetrameric vimentin disassembled from vimentin filaments in HeLa cells. Serine 139-145 vimentin Homo sapiens 130-138 22846177-5 2012 The interaction with GlcNAc-bearing polymers promoted the cell surface recruitment of vimentin followed by the phosphorylation of vimentin serine 71 and the increase in tetrameric vimentin disassembled from vimentin filaments in HeLa cells. Serine 139-145 vimentin Homo sapiens 130-138 22846177-7 2012 These results suggest that interactions between surface vimentin and GlcNAc molecules, including the O-GlcNAc proteins from dying cells, may play a pivotal role in vimentin expression and the migration of cancer cells. Acetylglucosamine 69-75 vimentin Homo sapiens 56-64 22846177-7 2012 These results suggest that interactions between surface vimentin and GlcNAc molecules, including the O-GlcNAc proteins from dying cells, may play a pivotal role in vimentin expression and the migration of cancer cells. Acetylglucosamine 69-75 vimentin Homo sapiens 164-172 22697487-9 2012 Formalin fixation without antigen retrieval led to inadequate visualization of alpha-SMA, vimentin, type I- and type III collagen, and laminin. Formaldehyde 0-8 vimentin Homo sapiens 90-98 22381301-2 2012 METHODS: The results of reoperation with cZi DBS in five patients with failed Vim DBS were retrospectively analyzed. czi dbs 41-48 vimentin Homo sapiens 78-81 23095131-8 2012 In FGF-2 treated tubular cells, sulodexide also prevents the over-expression of the mesenchymal markers alphaSMA, vimentin and fibronectin and the motility increase, i.e. the epithelial-mesenchymal transition of tubular cells. glucuronyl glucosamine glycan sulfate 32-42 vimentin Homo sapiens 114-122 22957988-5 2012 Our results illustrated that TGF-beta was able to induce EMT in NSCLC cells, and EGCG would reverse TGF-beta-induced morphological changes, up-regulate the expression of E-cadherin, and down-regulate the expression of vimentin. epigallocatechin gallate 81-85 vimentin Homo sapiens 218-226 22957988-6 2012 Immunofluorescent staining also demonstrated that E-cadherin was up-regulated and that vimentin was down-regulated by EGCG pretreatment. epigallocatechin gallate 118-122 vimentin Homo sapiens 87-95 21882253-5 2012 Interestingly, celecoxib prevented EMT-related changes, as shown by modifications of beta-catenin intracellular localization or vimentin and E-cadherin levels, as well as HT-29 invasiveness induced by hypoxia, EGF, or hypoxia plus EGF. Celecoxib 15-24 vimentin Homo sapiens 128-136 24175842-5 2013 Menadione induced the expression of E-cadherin but reduced the expression of EMT markers, vimentin and fibronectin. Vitamin K 3 0-9 vimentin Homo sapiens 90-98 23994953-5 2013 The sole presence of erlotinib was capable of rapidly activate an IGF-1R-dependent, vimentin-enriched mesenchymal-like phenotype in delE746-A750-mutated epithelial cells. Erlotinib Hydrochloride 21-30 vimentin Homo sapiens 84-92 22846177-0 2012 Dynamic behaviors of vimentin induced by interaction with GlcNAc molecules. Acetylglucosamine 58-64 vimentin Homo sapiens 21-29 23176396-12 2012 Contrary to expectations, salinomycin induced the expression of EMT markers Snail, vimentin, and Zeb-1, decreased expression of E-cadherin, and also induced phosphorylation of Akt and its downstream targets GSK3-beta and mTOR. salinomycin 26-37 vimentin Homo sapiens 83-91 22425263-4 2012 The anandamide treatment resulted in up-regulation of epithelial markers, like E-cadherin with a concomitant decrease in protein levels of mesenchymal markers, including vimentin and Snail1. anandamide 4-14 vimentin Homo sapiens 170-178 22584948-0 2012 Acquired resistance to peloruside A and laulimalide is associated with downregulation of vimentin in human ovarian carcinoma cells. peloruside A 23-35 vimentin Homo sapiens 89-97 22584948-0 2012 Acquired resistance to peloruside A and laulimalide is associated with downregulation of vimentin in human ovarian carcinoma cells. laulimalide 40-51 vimentin Homo sapiens 89-97 22584948-5 2012 Vimentin expression was restored in vimentin-deficient L4 cells by transfecting a full-length human vimentin cDNA, and sensitivity to PLA and LAU were tested using an MTT cell proliferation assay. monooxyethylene trimethylolpropane tristearate 167-170 vimentin Homo sapiens 0-8 22936401-6 2012 Proteasome inhibitor MG-132 significantly reduced expression of TGF-beta1 and vimentin. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 21-27 vimentin Homo sapiens 78-86 22936401-8 2012 Treatment with SB203580 and U0126 reduced PLpro-induced expression of TGF-beta1, vimentin, and type I collagen. SB 203580 15-23 vimentin Homo sapiens 81-89 22936401-8 2012 Treatment with SB203580 and U0126 reduced PLpro-induced expression of TGF-beta1, vimentin, and type I collagen. U 0126 28-33 vimentin Homo sapiens 81-89 22765310-2 2012 METHOD: Human native Vim was citrullinated with rabbit PAD in vitro and detected using a Western blot assay with anti-modified citrulline antibody (anti-MC Ab). Methylcholanthrene 153-155 vimentin Homo sapiens 21-24 22678114-6 2012 Strikingly, apricoxib treatment induced a dose-dependent reversal of epithelial-mesenchymal transition (EMT), as shown by robust upregulation of E-cadherin and the virtual disappearance of vimentin and ZEB1 protein expression. apricoxib 12-21 vimentin Homo sapiens 189-197 22410154-6 2012 In BxPC3 cells, the AFFL-SPE-LC-MS/MS method was used to detect significant differences in 24S-OHC levels between vimentin+ and vimentin- heterogenous sub-populations. 24-hydroxycholesterol 91-98 vimentin Homo sapiens 114-122 22732947-7 2012 Given the close proximity of Vim to Vc thalamus, the models suggest that dDBS will enable clinicians to more effectively sculpt current through and around thalamus in order to achieve a more consistent therapeutic effect without inducing side-effects. DDB 73-77 vimentin Homo sapiens 29-32 22766839-14 2012 These data suggest that VIM may function as an oncogene and is regulated by tumor suppressive miR-138. mir-138 94-101 vimentin Homo sapiens 24-27 23141445-6 2012 However, EGCG could reverse the TGF-beta1 mediated process of EMT by downregulating the expression of Vimentin and upregulating the expression of E-cadherin and Smad7. epigallocatechin gallate 9-13 vimentin Homo sapiens 102-110 22827697-3 2012 Immunoblot was performed to find that BTE could induce up-regulation of epithelial markers such as E-cadherin and inhibit mesenchymal markers such as snail-1 and vimentin. 2,1,3-Benzothiadiazol-4-amine 38-41 vimentin Homo sapiens 162-170 22698676-9 2012 Systemic rapamycin treatment of mammary tumors grown in a Cav-1-deficient microenvironment significantly inhibited their tumor growth, decreased their stromal content, and reduced the levels of both vimentin and phospho-S6 in Cav-1-deficient cancer-associated fibroblasts. Sirolimus 9-18 vimentin Homo sapiens 199-207 22177839-0 2012 Interactions of vimentin- or desmin-expressing liver cells with N-acetylglucosamine-bearing polymers. Acetylglucosamine 64-83 vimentin Homo sapiens 16-25 22549780-5 2012 We employed tandem mass spectrometry analysis to identify sites of ADP-ribosylation on vimentin. Adenosine Diphosphate 67-70 vimentin Homo sapiens 87-95 22416070-4 2012 In renal tubular cells, cytotoxic concentrations of cyclosporine A (CsA) inhibited both gene and protein expression of adherent and tight junction proteins (E-cadherin, ZO-1, claudin-1, and beta-catenin) and increased vimentin expression, without involvement of transforming growth factor beta1 or caspase activity. Cyclosporine 52-66 vimentin Homo sapiens 218-226 22416070-4 2012 In renal tubular cells, cytotoxic concentrations of cyclosporine A (CsA) inhibited both gene and protein expression of adherent and tight junction proteins (E-cadherin, ZO-1, claudin-1, and beta-catenin) and increased vimentin expression, without involvement of transforming growth factor beta1 or caspase activity. Cyclosporine 68-71 vimentin Homo sapiens 218-226 22690072-12 2012 We further detected the expression of E-cadherin and vimentin in cells treated with nigericin and oxaliplatin. Nigericin 84-93 vimentin Homo sapiens 53-61 22690072-12 2012 We further detected the expression of E-cadherin and vimentin in cells treated with nigericin and oxaliplatin. Oxaliplatin 98-109 vimentin Homo sapiens 53-61 22690072-13 2012 The results showed that HT29 cells treated with nigericin induced an increase in E-cadherin expression and a decrease in the vimentin expression relative to vehicle controls. Nigericin 48-57 vimentin Homo sapiens 125-133 22690072-14 2012 In contrast, oxaliplatin downregulated the expression of E-cadherin and upregulated the expression of vimentin in HT29 cells relative to vehicle controls. Oxaliplatin 13-24 vimentin Homo sapiens 102-110 22669117-0 2012 Roles of vimentin and 14-3-3 zeta/delta in the inhibitory effects of heparin on PC-3M cell proliferation and B16-F10-luc-G5 cells metastasis. Heparin 69-76 vimentin Homo sapiens 9-33 22669117-18 2012 Heparin 125 mug/mL decreased vimentin and E-cadherin mRNA transcription while increased TGF-beta mRNA transcription in the PC-3M cells, but the differences were not significant. Heparin 0-7 vimentin Homo sapiens 29-37 22407449-4 2012 Initial studies confirmed vimentin was required for sphingosine 1-phosphate (S1P)- and growth factor (GF)-induced endothelial cell invasion, and vimentin was cleaved by calpains during invasion. sphingosine 1-phosphate 52-75 vimentin Homo sapiens 26-34 22655012-6 2012 As an application of our device, we study the influence of divalent ions on vimentin intermediate filament networks in a quantitative way by tuning the magnesium concentration from drop to drop. Magnesium 152-161 vimentin Homo sapiens 76-84 22884073-8 2012 At the same time, genistein also could improve the progress of epithelial-mesenchymal transition (EMT) via morphology observation using light microscopy/transmission electron microscopy (TEM), which is mediated by the down-regulation of E-cadherin and the up-regulation of vimentin. Genistein 18-27 vimentin Homo sapiens 273-281 22371530-7 2012 Then neurite outgrowth was suppressed by genetic depletion of phospho-vimentin and beta1 integrin as well as inhibition of vimentin phosphorylation by Cdc2 inhibitor purvalanol A. 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine 166-178 vimentin Homo sapiens 123-131 22345628-0 2012 Engulfment and clearance of apoptotic cells based on a GlcNAc-binding lectin-like property of surface vimentin. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 55-61 vimentin Homo sapiens 102-110 22345628-4 2012 Previously, we reported that vimentin possesses a GlcNAc-binding lectin-like property on cell surface. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 50-56 vimentin Homo sapiens 29-37 22345628-5 2012 However, the physiological relevance of the surface localization and GlcNAc-binding property of vimentin remained unclear. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 69-75 vimentin Homo sapiens 96-104 22345628-6 2012 In the present study, we observed that O-GlcNAc proteins from apoptotic cells interacted with the surface vimentin of neighboring phagocytes and that this interaction induced serine 71-phosphorylation and recruitment of vimentin to the cell surface of the neighboring phagocytes. o-glcnac 39-47 vimentin Homo sapiens 106-114 22345628-6 2012 In the present study, we observed that O-GlcNAc proteins from apoptotic cells interacted with the surface vimentin of neighboring phagocytes and that this interaction induced serine 71-phosphorylation and recruitment of vimentin to the cell surface of the neighboring phagocytes. o-glcnac 39-47 vimentin Homo sapiens 220-228 22345628-6 2012 In the present study, we observed that O-GlcNAc proteins from apoptotic cells interacted with the surface vimentin of neighboring phagocytes and that this interaction induced serine 71-phosphorylation and recruitment of vimentin to the cell surface of the neighboring phagocytes. Serine 175-181 vimentin Homo sapiens 106-114 22345628-7 2012 Moreover, tetrameric vimentin that was disassembled by serine 71-phosphorylation possessed a GlcNAc-binding activity and was localized to the cell surface. Serine 55-61 vimentin Homo sapiens 21-29 22345628-7 2012 Moreover, tetrameric vimentin that was disassembled by serine 71-phosphorylation possessed a GlcNAc-binding activity and was localized to the cell surface. 2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose 93-99 vimentin Homo sapiens 21-29 22345628-10 2012 Our results suggest a common mechanism for the clearance of apoptotic cells, through the interaction of surface vimentin with O-GlcNAc-modified proteins. o-glcnac 126-134 vimentin Homo sapiens 112-120 22675821-2 2012 When ET becomes refractory to propranolol, primidone and other, second-choice compounds, deep brain stimulation of the VIM nucleus of the thalamus can be considered. Propranolol 30-41 vimentin Homo sapiens 119-122 22675821-2 2012 When ET becomes refractory to propranolol, primidone and other, second-choice compounds, deep brain stimulation of the VIM nucleus of the thalamus can be considered. Primidone 43-52 vimentin Homo sapiens 119-122 22517511-4 2012 Compared with the cells in the control group, the expressions of 14-3-3sigma and lamin-A/C of the cells treated by berberine for 48 h increased by 94.12 and 5.24 times, respectively, and the expressions of annexin A5, cytokeratin 17, prohibitin, heat shock cognate 71 kDa protein (HSPA8), programmed cell death 6 and vimentin decreased by 4.1, 1.34, 23.8, 11.85, 4.63 and 5.24 times, respectively. Berberine 115-124 vimentin Homo sapiens 317-325 22320434-6 2012 Thickening and plaque deposits made by smooth muscle alpha actin- and vimentin-positive cells in a glycosaminoglycan matrix were observed. Glycosaminoglycans 99-116 vimentin Homo sapiens 70-78 22177839-0 2012 Interactions of vimentin- or desmin-expressing liver cells with N-acetylglucosamine-bearing polymers. Polymers 92-100 vimentin Homo sapiens 16-25 22177839-5 2012 It has previously been reported that mesenchymal cells adhered to GlcNAc-bearing polymer-coated dishes through surface vimentin. Acetylglucosamine 66-72 vimentin Homo sapiens 119-127 22177839-6 2012 It was also observed that nonparenchymal cells expressing vimentin or desmin specifically adhered to GlcNAc-bearing polymer-coated dishes. Acetylglucosamine 101-107 vimentin Homo sapiens 58-66 22177839-6 2012 It was also observed that nonparenchymal cells expressing vimentin or desmin specifically adhered to GlcNAc-bearing polymer-coated dishes. Polymers 116-123 vimentin Homo sapiens 58-66 22343435-13 2012 Cobalt pretreatment also reduced the CsA-induced phosphorylation of NF-kappaB and the CsA-induced expression of vimentin and alpha-smooth muscle actin, suggesting the attenuation of inflammation and fibrosis. Cobalt 0-6 vimentin Homo sapiens 112-120 22343435-13 2012 Cobalt pretreatment also reduced the CsA-induced phosphorylation of NF-kappaB and the CsA-induced expression of vimentin and alpha-smooth muscle actin, suggesting the attenuation of inflammation and fibrosis. Cyclosporine 86-89 vimentin Homo sapiens 112-120 21465480-8 2012 Decreased GTP-induced vimentin Ser56 phosphorylation and secretion resulted from inhibition of Cdk5 activity by roscovitine or olomoucine or by depletion of Cdk5 by siRNA, suggesting that GTP-induced Cdk5-mediated vimentin Ser56 phosphorylation may be related to GTP-induced Cdk5-mediated secretion by neutrophils. olomoucine 127-137 vimentin Homo sapiens 22-30 22287743-7 2012 The OS (HR) for vimentin(+) versus vimentin(-) in the erlotinib-treated patients was 0.65 (0.31-1.38) compared to 2.32 (1.09-4.94) in the placebo-treated patients and the OS (HR) for erlotinib versus placebo was 0.26 (0.11-0.63) in vimentin(+) compared to 0.99 (0.55-1.76) in the vimentin(-) patients. Erlotinib Hydrochloride 54-63 vimentin Homo sapiens 16-24 22287743-7 2012 The OS (HR) for vimentin(+) versus vimentin(-) in the erlotinib-treated patients was 0.65 (0.31-1.38) compared to 2.32 (1.09-4.94) in the placebo-treated patients and the OS (HR) for erlotinib versus placebo was 0.26 (0.11-0.63) in vimentin(+) compared to 0.99 (0.55-1.76) in the vimentin(-) patients. Erlotinib Hydrochloride 54-63 vimentin Homo sapiens 35-43 22287743-7 2012 The OS (HR) for vimentin(+) versus vimentin(-) in the erlotinib-treated patients was 0.65 (0.31-1.38) compared to 2.32 (1.09-4.94) in the placebo-treated patients and the OS (HR) for erlotinib versus placebo was 0.26 (0.11-0.63) in vimentin(+) compared to 0.99 (0.55-1.76) in the vimentin(-) patients. Erlotinib Hydrochloride 54-63 vimentin Homo sapiens 35-43 22287743-7 2012 The OS (HR) for vimentin(+) versus vimentin(-) in the erlotinib-treated patients was 0.65 (0.31-1.38) compared to 2.32 (1.09-4.94) in the placebo-treated patients and the OS (HR) for erlotinib versus placebo was 0.26 (0.11-0.63) in vimentin(+) compared to 0.99 (0.55-1.76) in the vimentin(-) patients. Erlotinib Hydrochloride 54-63 vimentin Homo sapiens 35-43 22287743-7 2012 The OS (HR) for vimentin(+) versus vimentin(-) in the erlotinib-treated patients was 0.65 (0.31-1.38) compared to 2.32 (1.09-4.94) in the placebo-treated patients and the OS (HR) for erlotinib versus placebo was 0.26 (0.11-0.63) in vimentin(+) compared to 0.99 (0.55-1.76) in the vimentin(-) patients. Erlotinib Hydrochloride 183-192 vimentin Homo sapiens 16-24 22287743-9 2012 E-Cadherin and vimentin are biomarkers worthy of additional study as predictive markers of outcome of erlotinib therapy. Erlotinib Hydrochloride 102-111 vimentin Homo sapiens 15-23 21465480-0 2012 Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils. Guanosine Triphosphate 52-55 vimentin Homo sapiens 14-22 21465480-5 2012 In response to neutrophil stimulation with GTP, vimentin Ser56 was phosphorylated and colocalized with Cdk5 in the cytoplasmic compartment. Guanosine Triphosphate 43-46 vimentin Homo sapiens 48-56 21465480-8 2012 Decreased GTP-induced vimentin Ser56 phosphorylation and secretion resulted from inhibition of Cdk5 activity by roscovitine or olomoucine or by depletion of Cdk5 by siRNA, suggesting that GTP-induced Cdk5-mediated vimentin Ser56 phosphorylation may be related to GTP-induced Cdk5-mediated secretion by neutrophils. Guanosine Triphosphate 10-13 vimentin Homo sapiens 22-30 21465480-8 2012 Decreased GTP-induced vimentin Ser56 phosphorylation and secretion resulted from inhibition of Cdk5 activity by roscovitine or olomoucine or by depletion of Cdk5 by siRNA, suggesting that GTP-induced Cdk5-mediated vimentin Ser56 phosphorylation may be related to GTP-induced Cdk5-mediated secretion by neutrophils. Guanosine Triphosphate 10-13 vimentin Homo sapiens 214-222 21465480-8 2012 Decreased GTP-induced vimentin Ser56 phosphorylation and secretion resulted from inhibition of Cdk5 activity by roscovitine or olomoucine or by depletion of Cdk5 by siRNA, suggesting that GTP-induced Cdk5-mediated vimentin Ser56 phosphorylation may be related to GTP-induced Cdk5-mediated secretion by neutrophils. Roscovitine 112-123 vimentin Homo sapiens 22-30 22561438-6 2012 Protein expression of galectin-1 in HPMCs significantly increased in PDS groups with a dose dependent manner (P<0.05).Expression of vimentin in HPMCs significantly increased in PDS groups, especially in groups of 2.5% PDS and 4.25% PDS (P<0.05), but zo-1 expression markedly decreased (P<0.05). 3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione 69-72 vimentin Homo sapiens 135-143 22561438-6 2012 Protein expression of galectin-1 in HPMCs significantly increased in PDS groups with a dose dependent manner (P<0.05).Expression of vimentin in HPMCs significantly increased in PDS groups, especially in groups of 2.5% PDS and 4.25% PDS (P<0.05), but zo-1 expression markedly decreased (P<0.05). 3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione 180-183 vimentin Homo sapiens 135-143 22561438-6 2012 Protein expression of galectin-1 in HPMCs significantly increased in PDS groups with a dose dependent manner (P<0.05).Expression of vimentin in HPMCs significantly increased in PDS groups, especially in groups of 2.5% PDS and 4.25% PDS (P<0.05), but zo-1 expression markedly decreased (P<0.05). 3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione 180-183 vimentin Homo sapiens 135-143 22561438-6 2012 Protein expression of galectin-1 in HPMCs significantly increased in PDS groups with a dose dependent manner (P<0.05).Expression of vimentin in HPMCs significantly increased in PDS groups, especially in groups of 2.5% PDS and 4.25% PDS (P<0.05), but zo-1 expression markedly decreased (P<0.05). 3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione 180-183 vimentin Homo sapiens 135-143 22561438-8 2012 Expression of vimentin in groups of 4.25% PDS was markedly inhibited (P<0.05) by galectin-1 siRNA, whereas zo-1 expression was significantly increased (P<0.05). 3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione 42-45 vimentin Homo sapiens 14-22 22178606-3 2012 We report here that high glucose (HG) treatment stimulated astrocytic morphological alteration coupled with changes in glial fibrillary acidic protein (GFAP) and vimentin expression. Glucose 25-32 vimentin Homo sapiens 162-170 21465480-8 2012 Decreased GTP-induced vimentin Ser56 phosphorylation and secretion resulted from inhibition of Cdk5 activity by roscovitine or olomoucine or by depletion of Cdk5 by siRNA, suggesting that GTP-induced Cdk5-mediated vimentin Ser56 phosphorylation may be related to GTP-induced Cdk5-mediated secretion by neutrophils. Guanosine Triphosphate 188-191 vimentin Homo sapiens 22-30 21465480-8 2012 Decreased GTP-induced vimentin Ser56 phosphorylation and secretion resulted from inhibition of Cdk5 activity by roscovitine or olomoucine or by depletion of Cdk5 by siRNA, suggesting that GTP-induced Cdk5-mediated vimentin Ser56 phosphorylation may be related to GTP-induced Cdk5-mediated secretion by neutrophils. Guanosine Triphosphate 188-191 vimentin Homo sapiens 22-30 21465480-9 2012 Indeed, inhibition of vimentin Ser56 phosphorylation led to a corresponding inhibition of GTP-induced secretion, indicating a link between these two events. Guanosine Triphosphate 90-93 vimentin Homo sapiens 22-30 22119849-0 2012 Stabilization of vimentin coil2 fragment via an engineered disulfide. Disulfides 59-68 vimentin Homo sapiens 17-25 21770894-3 2011 In the present study, we demonstrated that these miR-138-induced changes were accompanied by marked reduction in E-cad (E-cadherin) expression and enhanced Vim (vimentin) expression, characteristics of EMT (epithelial-mesenchymal transition). mir-138 49-56 vimentin Homo sapiens 156-159 23024790-3 2012 We found that HDACIs Trichostatin A (TSA) and Suberoylanilide hydroxamic acid (SAHA) could induce epithelial-to-mesenchymal transition (EMT) phenotype in prostate cancer (PCa) cells, which was associated with changes in cellular morphology consistent with increased expression of transcription factors ZEB1, ZEB2 and Slug, and mesenchymal markers such as vimentin, N-cadherin and Fibronectin. trichostatin A 21-35 vimentin Homo sapiens 355-363 23024790-3 2012 We found that HDACIs Trichostatin A (TSA) and Suberoylanilide hydroxamic acid (SAHA) could induce epithelial-to-mesenchymal transition (EMT) phenotype in prostate cancer (PCa) cells, which was associated with changes in cellular morphology consistent with increased expression of transcription factors ZEB1, ZEB2 and Slug, and mesenchymal markers such as vimentin, N-cadherin and Fibronectin. trichostatin A 37-40 vimentin Homo sapiens 355-363 23024790-3 2012 We found that HDACIs Trichostatin A (TSA) and Suberoylanilide hydroxamic acid (SAHA) could induce epithelial-to-mesenchymal transition (EMT) phenotype in prostate cancer (PCa) cells, which was associated with changes in cellular morphology consistent with increased expression of transcription factors ZEB1, ZEB2 and Slug, and mesenchymal markers such as vimentin, N-cadherin and Fibronectin. Vorinostat 46-77 vimentin Homo sapiens 355-363 23024790-3 2012 We found that HDACIs Trichostatin A (TSA) and Suberoylanilide hydroxamic acid (SAHA) could induce epithelial-to-mesenchymal transition (EMT) phenotype in prostate cancer (PCa) cells, which was associated with changes in cellular morphology consistent with increased expression of transcription factors ZEB1, ZEB2 and Slug, and mesenchymal markers such as vimentin, N-cadherin and Fibronectin. Vorinostat 79-83 vimentin Homo sapiens 355-363 22900077-6 2012 Vimentin is a primary target of Withaferin-A (WF-A). withaferin A 32-44 vimentin Homo sapiens 0-8 22720028-1 2012 Withaferin A (WFA) is a steroidal lactone present in Withania somnifera which has been shown in vitro to bind to the intermediate filament protein, vimentin. withaferin A 0-12 vimentin Homo sapiens 148-156 22720028-1 2012 Withaferin A (WFA) is a steroidal lactone present in Withania somnifera which has been shown in vitro to bind to the intermediate filament protein, vimentin. withaferin A 14-17 vimentin Homo sapiens 148-156 22720028-1 2012 Withaferin A (WFA) is a steroidal lactone present in Withania somnifera which has been shown in vitro to bind to the intermediate filament protein, vimentin. Lactones 34-41 vimentin Homo sapiens 148-156 22720028-4 2012 This reorganization is dose dependent and is accompanied by a change in cell shape, decreased motility and an increase in vimentin phosphorylation at serine-38. Serine 150-156 vimentin Homo sapiens 122-130 22720028-5 2012 Furthermore, vimentin lacking cysteine-328, the proposed WFA binding site, remains sensitive to WFA demonstrating that this site is not required for its cellular effects. Cysteine 30-38 vimentin Homo sapiens 13-21 22299051-8 2012 Overexpression of EGFR and high NF-kappaB activity play a key role in the epithelial-to-mesenchymal transition, which is of critical importance in the processes underlying metastasis, and we found treatment with GSPs enhanced the levels of epithelial (E-cadherin, cytokeratins and desmoglein-2) and reduced the levels of mesenchymal (vimentin, fibronectin, N-cadherin and Slug) biomarkers in the OSC19 cells. Grape Seed Proanthocyanidins 212-216 vimentin Homo sapiens 334-342 23251387-6 2012 Beyond promotion of "cadherin switching", another sign of the CAF-triggered epithelial-mesenchymal transition (EMT) was the induction of vimentin expression in MCF-7 cells. cafestol palmitate 62-65 vimentin Homo sapiens 137-145 21770894-3 2011 In the present study, we demonstrated that these miR-138-induced changes were accompanied by marked reduction in E-cad (E-cadherin) expression and enhanced Vim (vimentin) expression, characteristics of EMT (epithelial-mesenchymal transition). mir-138 49-56 vimentin Homo sapiens 161-169 21770894-5 2011 Direct targeting of miR-138 to specific sequences located in the mRNAs of the VIM, ZEB2 and EZH2 genes was confirmed using luciferase reporter gene assays. mir-138 20-27 vimentin Homo sapiens 78-81 22127234-6 2011 shRNA-driven silencing of the ATG12 gene and disabling the final step in the autophagy pathway by the antimalarial drug chloroquine both prevented TGFb1-induced accumulation of vimentin in JIMT-1 cells. Chloroquine 120-131 vimentin Homo sapiens 177-185 21924258-9 2011 Repression of vimentin and disturbance of antioxidative mechanisms may represent vulnerable points in tumor cellular defense against cisplatin. Cisplatin 133-142 vimentin Homo sapiens 14-22 21981664-4 2011 With this aim, the epitope anticitrullinated vimentin antibody response was mapped using synthetic peptides. Peptides 99-107 vimentin Homo sapiens 45-53 21803052-3 2011 We found by protein precipitation of endothelial cell lysates that the 12 amino acid SP peptide binds cell surface vimentin. amino acid sp 74-87 vimentin Homo sapiens 115-123 21803052-7 2011 The specificity of SP binding to vimentin was demonstrated by SP inhibition of anti-vimentin binding and by the inhibition of tube formation in cells transfected with siRNA against vimentin. TFF2 protein, human 19-21 vimentin Homo sapiens 33-41 21803052-7 2011 The specificity of SP binding to vimentin was demonstrated by SP inhibition of anti-vimentin binding and by the inhibition of tube formation in cells transfected with siRNA against vimentin. TFF2 protein, human 19-21 vimentin Homo sapiens 84-92 21803052-7 2011 The specificity of SP binding to vimentin was demonstrated by SP inhibition of anti-vimentin binding and by the inhibition of tube formation in cells transfected with siRNA against vimentin. TFF2 protein, human 19-21 vimentin Homo sapiens 84-92 21803052-7 2011 The specificity of SP binding to vimentin was demonstrated by SP inhibition of anti-vimentin binding and by the inhibition of tube formation in cells transfected with siRNA against vimentin. TFF2 protein, human 62-64 vimentin Homo sapiens 33-41 21803052-7 2011 The specificity of SP binding to vimentin was demonstrated by SP inhibition of anti-vimentin binding and by the inhibition of tube formation in cells transfected with siRNA against vimentin. TFF2 protein, human 62-64 vimentin Homo sapiens 84-92 21803052-7 2011 The specificity of SP binding to vimentin was demonstrated by SP inhibition of anti-vimentin binding and by the inhibition of tube formation in cells transfected with siRNA against vimentin. TFF2 protein, human 62-64 vimentin Homo sapiens 84-92 22127234-8 2011 Chloroquine treatment augmented the number of CD24(+) cells and concomitantly reduced constitutive overexpression of vimentin in MDA-MB-231 cells. Chloroquine 0-11 vimentin Homo sapiens 117-125 21069453-7 2011 Treatments of human non-tumorigenic mammary epithelial and breast tumor cells with Lidocaine or Tetracaine caused rapid collapse of vimentin filaments. Lidocaine 83-92 vimentin Homo sapiens 132-140 21069453-7 2011 Treatments of human non-tumorigenic mammary epithelial and breast tumor cells with Lidocaine or Tetracaine caused rapid collapse of vimentin filaments. Tetracaine 96-106 vimentin Homo sapiens 132-140 21733881-5 2011 LMWH affected the morphology of vimentin and the expression levels of alpha(v) integrin and PP-1B in HUVECs bound to PC-3M cells. Heparin, Low-Molecular-Weight 0-4 vimentin Homo sapiens 32-40 21618587-4 2011 We demonstrate that cisplatin-induced transition from epithelial to mesenchymal morphology in residual cancer cells correlated with reduced E-cadherin, and increased N-cadherin and vimentin expression. Cisplatin 20-29 vimentin Homo sapiens 181-189 21733881-0 2011 Role of vimentin in the inhibitory effects of low-molecular-weight heparin on PC-3M cell adhesion to, and migration through, endothelium. Heparin 67-74 vimentin Homo sapiens 8-16 21733881-4 2011 Using proteomics, we surveyed the global protein changes in HUVECs after LMWH treatment and identified four down-regulated proteins that were possible isoforms of cytoskeletal vimentin intermediate filaments, cartilage-derived C-type lectin, and serine/threonine protein phosphatase 1beta (PP-1B). Heparin, Low-Molecular-Weight 73-77 vimentin Homo sapiens 176-184 21806057-7 2011 Osthole also effectively inhibited the HGF-induced decrease of E-cadherin and increase of vimentin via down-regulation of phosphorylated Akt and mTOR. osthol 0-7 vimentin Homo sapiens 90-98 21778273-11 2011 The expressions of VEGFR2, phospho-VEGFR2, and vimentin were downregulated by trehalose. Trehalose 78-87 vimentin Homo sapiens 47-55 21823612-10 2011 Furthermore, we found that intracellular calcium mobilization is essential and sufficient for the cleavage of vimentin. Calcium 41-48 vimentin Homo sapiens 110-118 21998958-6 2011 The results showed that vimentin gene was amplified successfully and expressed as identified by SDS-PAGE and Western blot. Sodium Dodecyl Sulfate 96-99 vimentin Homo sapiens 24-32 21707907-7 2011 Furthermore, RP-2ms mainly depended on cell surface glycosaminoglycans for viral binding and it became vimentin-dependent only when binding to glycosaminoglycans was blocked. Glycosaminoglycans 143-161 vimentin Homo sapiens 103-111 21660961-5 2011 In gefitinib-resistant KB and Hep-2 cells, both of which had undergone EMT and expressed very low levels of ErbB3, vorinostat reverted the mesenchymal phenotype by inducing both E-cadherin and ErbB3 and downregulating vimentin as well as EGFR and ErbB2. Vorinostat 115-125 vimentin Homo sapiens 218-226 21645522-4 2011 Here we present crystal structures of VIM-7 as the native enzyme, with Cys221 oxidized (VIM-7-Ox), and with a sulfur atom bridging the two active-site zinc ions (VIM-7-S). Sulfur 110-116 vimentin Homo sapiens 38-41 21810412-5 2011 The vimentin expression was suppressed under high-calcium condition. Calcium 50-57 vimentin Homo sapiens 4-12 21645522-5 2011 Comparison with VIM-2 and VIM-4 structures suggests an explanation for the reduced catalytic efficiency of VIM-7 against cephalosporins with a positively charged cyclic substituent at the C3 position (e.g., ceftazidime). Ceftazidime 207-218 vimentin Homo sapiens 16-19 21645522-5 2011 Comparison with VIM-2 and VIM-4 structures suggests an explanation for the reduced catalytic efficiency of VIM-7 against cephalosporins with a positively charged cyclic substituent at the C3 position (e.g., ceftazidime). Ceftazidime 207-218 vimentin Homo sapiens 26-29 21645522-8 2011 Docking of the cephalosporins ceftazidime and cefotaxime into the VIM-2 and VIM-7 structures reveals that amino acid substitutions may cause the mode of substrate binding to differ between the two enzymes. Cephalosporins 15-29 vimentin Homo sapiens 66-69 21645522-8 2011 Docking of the cephalosporins ceftazidime and cefotaxime into the VIM-2 and VIM-7 structures reveals that amino acid substitutions may cause the mode of substrate binding to differ between the two enzymes. Ceftazidime 30-41 vimentin Homo sapiens 66-69 21645522-8 2011 Docking of the cephalosporins ceftazidime and cefotaxime into the VIM-2 and VIM-7 structures reveals that amino acid substitutions may cause the mode of substrate binding to differ between the two enzymes. Cefotaxime 46-56 vimentin Homo sapiens 66-69 21590825-1 2011 A new ionic-liquid monomer, 1-vinyl-3-octadecylimidazolium bromide ([C(18)VIm]Br), was prepared and polymerized on porous silica particles by means of a surface-initiated radical chain-transfer reaction. SCHEMBL2395675 28-66 vimentin Homo sapiens 74-77 21851624-8 2011 Ectopic expression of miR-194 in EC cells induced a mesenchymal to epithelial transition (MET) by restoring E-cadherin, reducing Vimentin expression, and inhibiting cell invasion in vitro. mir-194 22-29 vimentin Homo sapiens 129-137 21498628-7 2011 Addition of a TGF-beta receptor kinase inhibitor (SB431542) to cells cultured on fibronectin inhibited vimentin expression and maintained pro-SPC expression, indicating persistence of an epithelial phenotype. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 50-58 vimentin Homo sapiens 103-111 21083634-6 2011 E. coli-induced PMN transmigration was markedly inhibited by withaferin A, a dual inhibitor of vimentin and proteasome. withaferin A 61-73 vimentin Homo sapiens 95-103 21590825-1 2011 A new ionic-liquid monomer, 1-vinyl-3-octadecylimidazolium bromide ([C(18)VIm]Br), was prepared and polymerized on porous silica particles by means of a surface-initiated radical chain-transfer reaction. Silicon Dioxide 122-128 vimentin Homo sapiens 74-77 21267784-10 2011 Moreover, salinomycin downregulates the expression of vimentin and induces the E-cadherin expression in HT29 cells. salinomycin 10-21 vimentin Homo sapiens 54-62 21504235-0 2011 Diosgenin suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition by down-regulation of Mdm2 and vimentin. Diosgenin 0-9 vimentin Homo sapiens 125-133 21677875-4 2011 We showed that treatment with the non-peptide alpha(v)-integrin antagonist GLPG0187 dose-dependently increased the E-cadherin/vimentin ratio, rendering the cells a more epithelial, sessile phenotype. GLPG0187 75-83 vimentin Homo sapiens 126-134 21677876-3 2011 Interestingly, ADT also induced high levels of vimentin expression in prostate cancer cell lines in vitro and in human prostate tumors in vivo. adt 15-18 vimentin Homo sapiens 47-55 21504235-6 2011 Moreover, diosgenin effectively inhibited the HGF-induced increases in Mdm2 and vimentin by down-regulating phosphorylated Akt and mTOR. Diosgenin 10-19 vimentin Homo sapiens 80-88 21329974-0 2011 Gene delivery system based on highly specific recognition of surface-vimentin with N-acetylglucosamine immobilized polyethylenimine. Acetylglucosamine 83-102 vimentin Homo sapiens 69-77 21316642-6 2011 VEGF and phosphotyrosine immunostaining predominated in the invasive extravillous trophoblasts that coexpressed vimentin and cytokeratin-7, an epithelial-to-mesenchymal transition feature and tumorlike cell phenotype. Phosphotyrosine 9-24 vimentin Homo sapiens 112-120 21329974-0 2011 Gene delivery system based on highly specific recognition of surface-vimentin with N-acetylglucosamine immobilized polyethylenimine. Polyethyleneimine 115-131 vimentin Homo sapiens 69-77 21329974-2 2011 Here, we report that N-acetylglucosamine (GlcNAc) with polyethylenimine (GlcNAc-PEI) specifically interacted with vimentin-expressing cells such as 293FT and HeLa cells. Acetylglucosamine 21-40 vimentin Homo sapiens 114-122 21329974-2 2011 Here, we report that N-acetylglucosamine (GlcNAc) with polyethylenimine (GlcNAc-PEI) specifically interacted with vimentin-expressing cells such as 293FT and HeLa cells. Acetylglucosamine 42-48 vimentin Homo sapiens 114-122 21329974-2 2011 Here, we report that N-acetylglucosamine (GlcNAc) with polyethylenimine (GlcNAc-PEI) specifically interacted with vimentin-expressing cells such as 293FT and HeLa cells. Polyethyleneimine 55-71 vimentin Homo sapiens 114-122 21329974-2 2011 Here, we report that N-acetylglucosamine (GlcNAc) with polyethylenimine (GlcNAc-PEI) specifically interacted with vimentin-expressing cells such as 293FT and HeLa cells. Acetylglucosamine 73-79 vimentin Homo sapiens 114-122 21329974-3 2011 Recently, the intermediate filaments vimentin and desmin have been reported to have GlcNAc-binding lectin-like properties on the cell surface. Acetylglucosamine 84-90 vimentin Homo sapiens 37-45 21329974-4 2011 Therefore, GlcNAc-conjugated agents can be targeted to vimentin- and desmin-expressing cells and tissues. Acetylglucosamine 11-17 vimentin Homo sapiens 55-63 21329974-5 2011 Vimentin-expressing 293FT and HeLa cells were efficiently transfected with green fluorescent protein and luciferase genes by using GlcNAc-PEI; the expression of these genes in vimentin-knockdown cells were low. Acetylglucosamine 131-137 vimentin Homo sapiens 0-8 21329974-6 2011 Confocal microscopic analysis showed that GlcNAc-PEI complexes interacted with vimentin on the cell surface of HeLa cells. Acetylglucosamine 42-48 vimentin Homo sapiens 79-87 21329974-7 2011 These results demonstrate that GlcNAc-PEI/DNA complexes were specifically taken up by 293FT and HeLa cells via vimentin. Acetylglucosamine 31-37 vimentin Homo sapiens 111-119 21423564-4 2011 The Q(i) and M(i) are measured with multiplicative errors Vi(Q) and ViM, so that Qi(mes)=Qi(tr)Vi(Q) (this is classical measurement error model) and Mi(tr)=Mi(mes)Vi(M) (this is Berkson measurement error model). 2-(N-morpholino)ethanesulfonic acid 84-87 vimentin Homo sapiens 68-71 21516532-6 2011 Here, we show using explicit water molecular dynamics and well-tempered metadynamics that for the coil2 domain of vimentin IFs the stutter is more stable in a non-alpha-helical, unfolded state. Water 29-34 vimentin Homo sapiens 114-122 21491170-1 2011 Multiple cytosine guanine dinucleotides (CpG island) are found in the VIM promoter region. cytidylyl-3'-5'-guanosine 9-39 vimentin Homo sapiens 70-73 21800536-5 2011 The EMT was induced by exposure of SMMC-7721 with 0.25 mmol.L-1 of sodium nitrite, which was characterized by increased level of Vimentin, decreased E-cadherin and elevated activity of migration and metastatic potential. smmc-7721 35-44 vimentin Homo sapiens 129-137 21800536-5 2011 The EMT was induced by exposure of SMMC-7721 with 0.25 mmol.L-1 of sodium nitrite, which was characterized by increased level of Vimentin, decreased E-cadherin and elevated activity of migration and metastatic potential. Sodium Nitrite 67-81 vimentin Homo sapiens 129-137 21388137-4 2011 We performed Western blot to find that EGCG inhibited p-focal adhesion kinase (p-FAK), p-Src, snail-1, and vimentin, indicating the anti-EMT effect of EGCG in oral squamous cell carcinoma. epigallocatechin gallate 39-43 vimentin Homo sapiens 107-115 21219539-7 2011 Treatment of both A431-P and A431-III cells with GM6001, a broad spectrum MMP inhibitor, resulted in the diminution of vimentin and fibronectin, indicating a role for MMP-9 in the induction of EMT. N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide 49-55 vimentin Homo sapiens 119-127 21325074-7 2011 We showed that sunitinib treatment induced major changes in the expression of genes involved in tissue invasion and metastasis including vimentin (VIM), urokinase plasminogen (PLAU), tenascin-C (TN-C), SPARC, and CD44. Sunitinib 15-24 vimentin Homo sapiens 137-145 21325074-7 2011 We showed that sunitinib treatment induced major changes in the expression of genes involved in tissue invasion and metastasis including vimentin (VIM), urokinase plasminogen (PLAU), tenascin-C (TN-C), SPARC, and CD44. Sunitinib 15-24 vimentin Homo sapiens 147-150 21485850-6 2011 The immobilization of Ag NPs onto the PS-VIm polymer matrix was performed using AgNO3 as a metal precursor solution. Silver Nitrate 80-85 vimentin Homo sapiens 41-44 21216232-6 2011 These findings suggest that the IRAP binding protein, vimentin, plays an important role in retention of GSVs. gsvs 104-108 vimentin Homo sapiens 54-62 21297102-6 2011 U0126, PKC412, PF2341066, dasatinib, and axitinib downregulated vimentin expression by 70% to 90% as compared to untreated spheroids. U 0126 0-5 vimentin Homo sapiens 64-72 21297102-6 2011 U0126, PKC412, PF2341066, dasatinib, and axitinib downregulated vimentin expression by 70% to 90% as compared to untreated spheroids. Dasatinib 26-35 vimentin Homo sapiens 64-72 21297102-6 2011 U0126, PKC412, PF2341066, dasatinib, and axitinib downregulated vimentin expression by 70% to 90% as compared to untreated spheroids. Axitinib 41-49 vimentin Homo sapiens 64-72 21385137-6 2011 RESULTS & DISCUSSION: Surface vimentin levels varied during cell cycle and among the cell lines tested. Adenosine Monophosphate 9-12 vimentin Homo sapiens 34-42 21138482-5 2011 This study investigated the impact of ANE on PI3K/AKT activation during vimentin expression. ane 38-41 vimentin Homo sapiens 72-80 21138482-6 2011 MATERIALS AND METHODS: Oral carcinoma cells were treated with ANE to explore the signaling changes underlying vimentin expression. ane 62-65 vimentin Homo sapiens 110-118 21138482-8 2011 RESULTS: After ANE treatment, the OECM-1 and Fadu cells developed a fibroblastoid morphology and there was an increase in vimentin expression. ane 15-18 vimentin Homo sapiens 122-130 21138482-10 2011 Blockage of phosphatidylinositol 3-kinase (PI3K)/AKT signaling attenuated vimentin expression when it was induced by ANE. ane 117-120 vimentin Homo sapiens 74-82 21224350-8 2011 In addition, 2DE-MS/MS and immunoblotting analyses showed that Lith-O-Asp altered the protein expression level and phosphorylation status of various proteins involved in crucial metastasis and angiogenesis pathways such as vimentin and ribonuclease/angiogenin inhibitor RNH1. Lith-O-Asp 63-73 vimentin Homo sapiens 223-231 21423689-5 2011 Proteins that showed increased expression levels upon Sal B treatment were vimentin, T-complex protein 1, protein disulfide isomerase, tropomyosin alpha, heat shock protein beta-1, UBX domain-containing protein 1, alpha enolase, and peroxiredoxin-2. salvianolic acid B 54-59 vimentin Homo sapiens 75-83 21093414-1 2011 Reactive oxygen species increases in various diseases including cancer and has been associated with induction of epithelial-mesenchymal transition (EMT), as evidenced by decrease in cell adhesion-associated molecules like E-cadherin, and increase in mesenchymal markers like vimentin. Reactive Oxygen Species 0-23 vimentin Homo sapiens 275-283 21196403-4 2011 Of particular interest, recent proteomics analysis has shown that treatment of coronary venular endothelial cells with a physiological level of L-arginine (e.g., 0.1 mM) increases expression of structural proteins (vimentin and tropomyosin) and cytochrome bc1 complex iii-chain A, while decreasing expression of stress-related proteins (PDZ domain containing-3), in these cells. Arginine 144-154 vimentin Homo sapiens 215-223 20602472-5 2011 Chondrocytes were embedded in alginate and vimentin networks disrupted with acrylamide. Acrylamide 76-86 vimentin Homo sapiens 43-51 20688745-6 2010 RESULTS: Hyperfluorescence indicating calcium activity was recorded in a population of abundant round boutons interspersed in a network of vimentin-positive processes located immediately external to the smooth muscle cell layer but internal to the perivascular glial cells. Calcium 38-45 vimentin Homo sapiens 139-147 22219636-12 2011 Rapamycin successfully inhibited cell migration at concentrations of 10 ng/ml, 100 ng/ml, and 1,000 ng/ml for a treatment period of up to 8 h. Different concentrations of rapamycin induced the expression of VE-cadherin, inhibited vimentin and Twist expression in the endothelial cells, and inhibited endothelial cell secretion of MMP-2 and MMP-9. Sirolimus 171-180 vimentin Homo sapiens 230-238 21384292-2 2011 The authors present a group of ET patients treated with deep brain stimulation of the ventral intermediate nucleus of the thalamus (Vim DBS). dibromsalan 136-139 vimentin Homo sapiens 132-135 21384292-3 2011 The aim of the study was to evaluate the efficacy and safety of Vim DBS in the treatment of ET. dibromsalan 68-71 vimentin Homo sapiens 64-67 21384292-4 2011 MATERIAL AND METHODS: Between 2006 and 2009, 8 female and 10 male ET patients were treated with Vim DBS. dibromsalan 100-103 vimentin Homo sapiens 96-99 21384292-13 2011 Head tremor reduction was reported by 75% of patients in the bilateral Vim DBS subgroup and 50% of patients in the unilateral Vim DBS subgroup. dibromsalan 130-133 vimentin Homo sapiens 126-129 21384292-15 2011 CONCLUSIONS: Vim DBS is a safe and effective method of ET treatment. dibromsalan 17-20 vimentin Homo sapiens 13-16 21384292-16 2011 Vim DBS improves activities of daily living of ET patients. dibromsalan 4-7 vimentin Homo sapiens 0-3 22022384-9 2011 Inhibition of melanoma cell migration by EGCG was associated with transition of mesenchymal stage to epithelial stage, which resulted in an increase in the levels of epithelial biomarkers (E-cadherin, cytokeratin and desmoglein 2) and a reduction in the levels of mesenchymal biomarkers (vimentin, fibronectin and N-cadherin) in A375 melanoma cells. epigallocatechin gallate 41-45 vimentin Homo sapiens 288-296 22219636-12 2011 Rapamycin successfully inhibited cell migration at concentrations of 10 ng/ml, 100 ng/ml, and 1,000 ng/ml for a treatment period of up to 8 h. Different concentrations of rapamycin induced the expression of VE-cadherin, inhibited vimentin and Twist expression in the endothelial cells, and inhibited endothelial cell secretion of MMP-2 and MMP-9. Sirolimus 0-9 vimentin Homo sapiens 230-238 21829520-7 2011 A significant decline in E-cadherin and CK expression and a notable increase in vimentin and alpha-SMA were detected when exposed to low glucose with TGF-beta1 or high glucose, and a significant raise of secreted fibronectin were detected when exposed to high glucose; whereas these changes were reversed when the cells were treated with p38 siRNA or AP-1 inhibitor (P<0.05). Glucose 137-144 vimentin Homo sapiens 80-88 21780650-0 2011 [Methotrexate-induced changes in the concentration of antibodies to mutaded citrullinated vimentin in blood serum of patients with rheumatoid arthritis]. Methotrexate 1-13 vimentin Homo sapiens 90-98 21780650-1 2011 AIM: To study effects of methotrexate on the titer of antibodies to mutated citrullinated vimentin (anti-MCV) and ascertain possibility of using this marker for control of treatment results and choice of individual effective dose of the drug. Methotrexate 25-37 vimentin Homo sapiens 90-98 20814740-0 2010 Alpha-lipoic acid modulates GFAP, vimentin, nestin, cyclin D1 and MAP-kinase expression in astroglial cell cultures. Thioctic Acid 0-17 vimentin Homo sapiens 34-42 21200089-3 2010 RESULTS: After stimulation by 30 mmol/L D-glucose, the protein and mRNA expression levels of vimentin in HK-2 cells increased in a time-dependent manner while the expression of ZO-1 was reduced significantly, especially at 48 h. Meanwhile, SARA was also decreased in a time-dependent manner. Glucose 40-49 vimentin Homo sapiens 93-101 20718984-8 2010 Furthermore, EGCG inhibits epithelial-mesenchymal transition by inhibiting the expression of vimentin, slug, snail and nuclear beta-catenin, and the activity of LEF-1/TCF responsive reporter, and also retards CSC"s migration and invasion, suggesting the blockade of signaling involved in early metastasis. (-)-Epigallocatechin gallate 13-17 vimentin Homo sapiens 93-101 20650271-5 2010 Expressions of vimentin and alpha smooth muscle actin (alpha-SMA) changed by trehalose were semiquantitatively measured by Western blot. Trehalose 77-86 vimentin Homo sapiens 15-23 20650271-11 2010 Expressions of vimentin and alpha-SMA were reduced by trehalose. Trehalose 54-63 vimentin Homo sapiens 15-23 20650271-13 2010 Immunohistochemical studies showed reduced staining of isolectin B4, vimentin and alpha-SMA in conjunctival wounds treated by topical trehalose. Trehalose 134-143 vimentin Homo sapiens 69-77 20634382-5 2010 Sera from SN-APS patients revealed 2 reactive spots corresponding to vimentin, a protein that is shown to bind cardiolipin in vitro. sn-aps 10-16 vimentin Homo sapiens 69-77 20634382-9 2010 Our results prompt to identify vimentin as a "new" cofactor for aPL, which may represent a useful tool mainly in SN-APS patients. sn-aps 113-119 vimentin Homo sapiens 31-39 20848133-7 2010 In addition, concomitant treatment of A549 cells with telmisartan, an angiotensin II receptor antagonist with antifibrotic properties, was found to reduce cytokine-induced collagen I production and cell migration, although expression levels of vimentin and E-cadherin remained unaltered. Telmisartan 54-65 vimentin Homo sapiens 244-252 20811684-9 2010 In comparison, mesenchymal cells demonstrated decreased vimentin expression with the treatment of vandetanib in the presence of EGF and VEGF. vandetanib 98-108 vimentin Homo sapiens 56-64 21829520-7 2011 A significant decline in E-cadherin and CK expression and a notable increase in vimentin and alpha-SMA were detected when exposed to low glucose with TGF-beta1 or high glucose, and a significant raise of secreted fibronectin were detected when exposed to high glucose; whereas these changes were reversed when the cells were treated with p38 siRNA or AP-1 inhibitor (P<0.05). Glucose 168-175 vimentin Homo sapiens 80-88 21829520-7 2011 A significant decline in E-cadherin and CK expression and a notable increase in vimentin and alpha-SMA were detected when exposed to low glucose with TGF-beta1 or high glucose, and a significant raise of secreted fibronectin were detected when exposed to high glucose; whereas these changes were reversed when the cells were treated with p38 siRNA or AP-1 inhibitor (P<0.05). Glucose 168-175 vimentin Homo sapiens 80-88 20615726-10 2010 CONCLUSIONS: The presence of DSA in AMR and CAV is significantly associated with development of Abs to MYO and VIM in post-HTx patients. dsa 29-32 vimentin Homo sapiens 111-114 21225515-2 2010 Neuromodulation with deep brain stimulation of the thalamic nucleus ventralis intermedius (Vim DBS) is a well accepted method of neurosurgical treatment of tremor related to essential tremor or Parkinson disease. dibromsalan 95-98 vimentin Homo sapiens 91-94 21225515-3 2010 Vim DBS is not widely used to control MS tremor. dibromsalan 4-7 vimentin Homo sapiens 0-3 21225515-4 2010 MATERIAL AND METHODS: Five MS patients with tremor (3 females and 2 males) were treated with Vim DBS. dibromsalan 97-100 vimentin Homo sapiens 93-96 21225515-16 2010 CONCLUSIONS: The study confirms the value and safety of Vim DBS for treatment of MS-related tremor. dibromsalan 60-63 vimentin Homo sapiens 56-59 20427712-12 2010 Knocking-down HSP27 destroys the vimentin filamentous network, and disrupting vimentin filaments with acrylamide increases endothelial permeability. Acrylamide 102-112 vimentin Homo sapiens 78-86 20623686-10 2010 Combined GPi-VIM-DBS can be useful in cases of incapaciting myoclonus, refractory to GPi-DBS alone. gpi-dbs 85-92 vimentin Homo sapiens 13-16 20458346-7 2010 Inimitable immunofluorescent microscopy represented in our high magnification images of vinculin, vimentin, and the actin cytoskeleton highlights the differences in fibroblast adhesion between fabricated silicone surfaces. Silicones 204-212 vimentin Homo sapiens 98-106 20729489-8 2010 Intriguing aspects of this regulation include the intracellular interplay of SERT with the small G protein Rab4 and the concerted 5HT-mediated phosphorylation of vimentin. Serotonin 130-133 vimentin Homo sapiens 162-170 20590589-7 2010 Treatment with DTNQ-Pro decreased HSP70 expression, and redistributed HSP27 and vimentin within the cell. (3,3')spiro((hexahydropyrrolo(1,2-a)pyrazine-1,4-dione)-6,3'-(2',3'-dihydrothieno(2,3-b)naphtho-4',9'-dione)) 15-23 vimentin Homo sapiens 80-88 19898866-5 2010 METHODS: We analyzed selected markers of senescence and cell death, including possible alterations in vimentin and G-actin cytoskeleton in A549 cells after treatment with doxorubicin. Doxorubicin 171-182 vimentin Homo sapiens 102-110 20406951-3 2010 Wild-type (WT) K-Ras cancer cells displaying high sensitivity to enzastaurin also expressed high mRNA levels of epithelial markers, such as E-cadherin (CDH1), and low mRNA expressions of mesenchymal markers, such as vimentin, N-cadherin (CDH2), and other genes frequently expressed in mesenchymal transition such as ZEB1, TWIST, SLUG, SNAIL, and TGFbeta. enzastaurin 65-76 vimentin Homo sapiens 216-224 20358123-6 2010 Correlation analysis with previously established immunochemical parameters showed that cells with a low cytokeratin-19 (ductal differentiation), high vimentin (mesenchymal marker), and high proliferative phenotype preferentially show higher uptake of mTHPC and subsequent phototoxicity. temoporfin 251-256 vimentin Homo sapiens 150-158 20332081-0 2010 Vimentin and desmin possess GlcNAc-binding lectin-like properties on cell surfaces. Acetylglucosamine 28-34 vimentin Homo sapiens 0-8 20332081-3 2010 Here, we found, using artificial biomimicking glycopolymers, that vimentin and desmin possess N-acetylglucosamine (GlcNAc)-binding lectin-like properties on the cell surfaces of various vimentin- and desmin-expressing cells such as cardiomyocytes and vascular smooth muscle cells. glycopolymers 46-59 vimentin Homo sapiens 66-74 20332081-3 2010 Here, we found, using artificial biomimicking glycopolymers, that vimentin and desmin possess N-acetylglucosamine (GlcNAc)-binding lectin-like properties on the cell surfaces of various vimentin- and desmin-expressing cells such as cardiomyocytes and vascular smooth muscle cells. Acetylglucosamine 94-113 vimentin Homo sapiens 66-74 20332081-3 2010 Here, we found, using artificial biomimicking glycopolymers, that vimentin and desmin possess N-acetylglucosamine (GlcNAc)-binding lectin-like properties on the cell surfaces of various vimentin- and desmin-expressing cells such as cardiomyocytes and vascular smooth muscle cells. Acetylglucosamine 115-121 vimentin Homo sapiens 66-74 20332081-3 2010 Here, we found, using artificial biomimicking glycopolymers, that vimentin and desmin possess N-acetylglucosamine (GlcNAc)-binding lectin-like properties on the cell surfaces of various vimentin- and desmin-expressing cells such as cardiomyocytes and vascular smooth muscle cells. Acetylglucosamine 115-121 vimentin Homo sapiens 186-194 20332081-7 2010 These results suggest that O-GlcNAc proteins might be one candidate for physiological GlcNAc-bearing ligands with which vimentin and desmin interact. Acetylglucosamine 29-35 vimentin Homo sapiens 120-128 20447406-4 2010 Rheological experiments reveal that vimentin networks stiffen with increasing concentrations of Ca(2+) and Mg(2+), showing that divalent cations act as crosslinkers. magnesium ion 107-113 vimentin Homo sapiens 36-44 20428808-4 2010 In the present study, we found that silibinin treatment resulted in the up-regulation of cytokeratin-18 and down-regulation of vimentin and MMP2, which was consistent with morphologic reversal of EMT phenotype leading to be epithelial. Silybin 36-45 vimentin Homo sapiens 127-135 19926703-1 2010 BACKGROUND AND PURPOSE: The Vim and VPL are important target regions of the thalamus for DBS. dibromsalan 89-92 vimentin Homo sapiens 28-31 19913099-4 2010 Inhibition of endogenous CSE by dl-propargylglycine led to spontaneous EMT, as manifested by decreased E-cadherin level, increased vimentin expression and fibroblast-like morphologic features. propargylglycine 32-51 vimentin Homo sapiens 131-139 19913099-5 2010 Exogenous H(2)S applied to TGF-beta1-treated A549 cells decreased vimentin expression, increased E-cadherin level and retained epithelial morphologic features. Hydrogen Sulfide 10-15 vimentin Homo sapiens 66-74 20088823-0 2010 Vimentin-mediated signalling is required for IbeA+ E. coli K1 invasion of human brain microvascular endothelial cells. ibea 45-49 vimentin Homo sapiens 0-8 20088823-2 2010 Vimentin was identified as an IbeA-binding protein on the surface of HBMECs (human BMECs). ibea 30-34 vimentin Homo sapiens 0-8 20088823-8 2010 Fourthly, IbeA+ E. coli and IbeA-coated beads induced the clustering of vimentin that was correlated with increased entry of bacteria and beads. ibea 10-14 vimentin Homo sapiens 72-80 20088823-8 2010 Fourthly, IbeA+ E. coli and IbeA-coated beads induced the clustering of vimentin that was correlated with increased entry of bacteria and beads. ibea 28-32 vimentin Homo sapiens 72-80 20088823-9 2010 Lastly, IbeA+ E. coli K1 invasion was inhibited by lipid-raft-disrupting agents (filipin and nystatin) and caveolin-1 siRNA (small interfering RNA), suggesting that caveolae/lipid rafts are signalling platforms for inducing IbeA-vimentin-mediated E. coli invasion of HBMECs. ibea 8-12 vimentin Homo sapiens 229-237 20007519-0 2010 A peripheral neuroimmune link: glutamate agonists upregulate NMDA NR1 receptor mRNA and protein, vimentin, TNF-alpha, and RANTES in cultured human synoviocytes. Glutamic Acid 31-40 vimentin Homo sapiens 97-105 19686041-7 2010 The carbonyl scavenger bisulfite suppressed acrolein toxicity, intermediate filament adduction, vimentin cross-linking, Hsp90 redistribution, and loss of cellular adhesive strength, while also suppressing vimentin hyperphosphorylation. hydrogen sulfite 23-32 vimentin Homo sapiens 96-104 19686041-7 2010 The carbonyl scavenger bisulfite suppressed acrolein toxicity, intermediate filament adduction, vimentin cross-linking, Hsp90 redistribution, and loss of cellular adhesive strength, while also suppressing vimentin hyperphosphorylation. hydrogen sulfite 23-32 vimentin Homo sapiens 205-213 20167812-7 2010 Furthermore, sequencing of sodium bisulfite-treated tumor DNA revealed more frequent methylation of 5"-CpG islands associated with the VIM and VIL2 genes in 1p/19q-deleted gliomas when compared with gliomas without these deletions. sodium bisulfite 27-43 vimentin Homo sapiens 135-138 20377773-9 2010 Pretreatment of the cells with SB203580 or PD98059 abolished the effect of urinary proteins from FSGS patients on the expression of alpha-SMA, vimentin and cytokeratin-18, while only SB203580 elicited this effect when cells were treated with urinary proteins from MCD patients. SB 203580 31-39 vimentin Homo sapiens 143-151 20335127-2 2010 METHODS: Immunohistochemical EnVison method was used to detect the expressions of ER, VIM, CEA and p16 in paraffin-embedded tissues from 31 cases of primary endocervical adenocarcinomas and 30 cases of endometrial adenocarcinomas. Paraffin 106-114 vimentin Homo sapiens 86-89 19776392-6 2010 Reduced vimentin phosphorylation, cell spreading, and beta1 integrin surface expression, and activation were phenocopied in cells treated with the protein kinase C inhibitor bisindolylmaleimide; cell spreading was also reduced by siRNA knockdown of protein kinase C-epsilon. bisindolylmaleimide 174-193 vimentin Homo sapiens 8-16 20377773-9 2010 Pretreatment of the cells with SB203580 or PD98059 abolished the effect of urinary proteins from FSGS patients on the expression of alpha-SMA, vimentin and cytokeratin-18, while only SB203580 elicited this effect when cells were treated with urinary proteins from MCD patients. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 43-50 vimentin Homo sapiens 143-151 19888472-7 2009 We found a good agreement between the contours of the deposited vimentin filaments on mica ("ideal" trapping) and on glass ("ideal" equilibrated) with our simulations. mica 86-90 vimentin Homo sapiens 64-72 20074516-4 2010 Tetramethylrhodamine was used to image the cytoskeleton (vimentin and microtubule-associated protein 2) as well as structures located at the cell membrane (caveolin and connexin-43) with a resolution down to 40 nm. tetramethylrhodamine 0-20 vimentin Homo sapiens 57-65 19860811-7 2010 RESULTS: We show alcohol upregulated the signature EMT phenotypic marker vimentin as well as matrix metalloprotease (MMP)-2, MMP-7, and MMP-9 and cell migration in colon and breast cancer cells-all characteristics of EMT. Alcohols 17-24 vimentin Homo sapiens 73-81 19860811-9 2010 Snail siRNA knockdown prevented alcohol-stimulated vimentin expression. Alcohols 32-39 vimentin Homo sapiens 51-59 19901092-8 2010 This enzyme was inhibited by EDTA and hydrolyzed penicillins, cephalosporins, and carbapenems, as observed for other VIM-type carbapenemases but with greater catalytic efficiency against penicillins than VIM-1. Edetic Acid 29-33 vimentin Homo sapiens 117-120 19901092-8 2010 This enzyme was inhibited by EDTA and hydrolyzed penicillins, cephalosporins, and carbapenems, as observed for other VIM-type carbapenemases but with greater catalytic efficiency against penicillins than VIM-1. Edetic Acid 29-33 vimentin Homo sapiens 204-207 19901092-8 2010 This enzyme was inhibited by EDTA and hydrolyzed penicillins, cephalosporins, and carbapenems, as observed for other VIM-type carbapenemases but with greater catalytic efficiency against penicillins than VIM-1. Penicillins 49-60 vimentin Homo sapiens 117-120 19901092-8 2010 This enzyme was inhibited by EDTA and hydrolyzed penicillins, cephalosporins, and carbapenems, as observed for other VIM-type carbapenemases but with greater catalytic efficiency against penicillins than VIM-1. Penicillins 49-60 vimentin Homo sapiens 204-207 19901092-8 2010 This enzyme was inhibited by EDTA and hydrolyzed penicillins, cephalosporins, and carbapenems, as observed for other VIM-type carbapenemases but with greater catalytic efficiency against penicillins than VIM-1. Cephalosporins 62-76 vimentin Homo sapiens 117-120 19901092-8 2010 This enzyme was inhibited by EDTA and hydrolyzed penicillins, cephalosporins, and carbapenems, as observed for other VIM-type carbapenemases but with greater catalytic efficiency against penicillins than VIM-1. Cephalosporins 62-76 vimentin Homo sapiens 204-207 19901092-8 2010 This enzyme was inhibited by EDTA and hydrolyzed penicillins, cephalosporins, and carbapenems, as observed for other VIM-type carbapenemases but with greater catalytic efficiency against penicillins than VIM-1. Carbapenems 82-93 vimentin Homo sapiens 117-120 19901092-8 2010 This enzyme was inhibited by EDTA and hydrolyzed penicillins, cephalosporins, and carbapenems, as observed for other VIM-type carbapenemases but with greater catalytic efficiency against penicillins than VIM-1. Carbapenems 82-93 vimentin Homo sapiens 204-207 19901092-8 2010 This enzyme was inhibited by EDTA and hydrolyzed penicillins, cephalosporins, and carbapenems, as observed for other VIM-type carbapenemases but with greater catalytic efficiency against penicillins than VIM-1. Penicillins 187-198 vimentin Homo sapiens 117-120 19901092-8 2010 This enzyme was inhibited by EDTA and hydrolyzed penicillins, cephalosporins, and carbapenems, as observed for other VIM-type carbapenemases but with greater catalytic efficiency against penicillins than VIM-1. Penicillins 187-198 vimentin Homo sapiens 204-207 20039411-6 2010 Peptides recognized in a citrulline-specific manner by T cells were selected and analyzed for their ability to be processed from the entire vimentin protein. Citrulline 25-35 vimentin Homo sapiens 140-148 20039411-11 2010 CONCLUSION: This study identifies, for the first time, 2 naturally processed peptides from vimentin that are recognized by HLA-DRB1*0401-restricted T cells in a citrulline-specific manner. Citrulline 161-171 vimentin Homo sapiens 91-99 19427413-5 2010 The anti-Sa antibody has been identified a decade ago; however, recent studies confirmed that anti-Sa is directed against citrullinated vimentin. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 9-11 vimentin Homo sapiens 136-144 20064087-9 2010 Interestingly, dexamethasone reduced expression levels of both vimentin and snail-1, whereas the influence of insulin was less pronounced. Dexamethasone 15-28 vimentin Homo sapiens 63-71 20064087-10 2010 An important result of this study is that 12 out of 17 analyzed EMT markers were transcriptionally influenced by dexamethasone (vimentin, snail-1, snail-2, HNF4 alpha, Twist-1, ZEB2, fibronectin, occludin, MMP14, claudin-1, cytokeratin-8, and cytokeratin-18), whereas the remaining factors seemed to be less dependent on dexamethasone. Dexamethasone 113-126 vimentin Homo sapiens 128-136 20036968-6 2010 In our recent researches we investigated the interactions between growth factors and dexamethasone on cytoskeletal proteins GFAP and vimentin expression under different experimental conditions. Dexamethasone 85-98 vimentin Homo sapiens 133-141 19937731-5 2010 siRNA-mediated knockdown of vimentin mRNA and protein triggered a reduction in the extent of MPC cartilage formation, as evidenced by depressed accumulation of mRNAs for the cartilage-specific marker genes aggrecan and collagen type II, as well as reduced levels of Alcian blue-stainable proteoglycan and collagen II protein in the extracellular matrix. Alcian Blue 266-277 vimentin Homo sapiens 28-36 20150368-8 2010 Suppression of OPN expression by 5-aza-dC was associated with reductions in MMP-2 secretion, vimentin expression, cell invasion, intravasation, and tumor growth. Decitabine 33-41 vimentin Homo sapiens 93-101 19801454-7 2009 Moreover, hypoxia-induced expression of alpha-SMA and vimentin was prevented in mitochondria-deficient rho(0) cells, which are incapable of ROS production during hypoxia. Reactive Oxygen Species 140-143 vimentin Homo sapiens 54-62 20003262-7 2009 At low concentrations, QUIN treatment induced concomitantly a marked increase in glial fibrillary acid protein levels and reduction in vimentin levels compared to controls; features consistent with astrogliosis. Quinolinic Acid 23-27 vimentin Homo sapiens 135-143 19812368-8 2009 Cdc42 activation, p21-activated kinase 1 (PAK1) phosphorylation at Thr-423 (an indication of PAK activation), and vimentin phosphorylation at Ser-56 in response to 5-HT activation were also attenuated in smooth muscle cells producing shRNA against p47(phox). Serine 142-145 vimentin Homo sapiens 114-122 19844232-7 2009 RESULTS: Exposure to 0.1% oxygen resulted in elevated levels of Snail protein, along with changes in vimentin and E-cadherin expression, and in addition increased migration of MDA-MB-468 cells. Oxygen 26-32 vimentin Homo sapiens 101-109 19513606-8 2009 The expression of Vimentin, phosphorylated beta-catenin, and TGF-beta1 was significantly blocked by chelerythrine chloride. chelerythrine 100-122 vimentin Homo sapiens 18-26 19584300-5 2009 Although the interaction between vimentin and IDE is enhanced by vimentin phosphorylation at Ser-55, the interaction between nestin and IDE is phosphorylation independent. Serine 93-96 vimentin Homo sapiens 33-41 19584300-5 2009 Although the interaction between vimentin and IDE is enhanced by vimentin phosphorylation at Ser-55, the interaction between nestin and IDE is phosphorylation independent. Serine 93-96 vimentin Homo sapiens 65-73 19656809-0 2009 Vimentin intermediate filaments as a template for silica nanotube preparation. Silicon Dioxide 50-56 vimentin Homo sapiens 0-8 19656809-3 2009 Sol-gel polymerization of tetraethoxysilane proceeded preferentially on the surface of IFs assembled from vimentin protein in vitro, resulting in silica-coated fibres. tetraethoxysilane 26-43 vimentin Homo sapiens 106-114 19656809-3 2009 Sol-gel polymerization of tetraethoxysilane proceeded preferentially on the surface of IFs assembled from vimentin protein in vitro, resulting in silica-coated fibres. Silicon Dioxide 146-152 vimentin Homo sapiens 106-114 19559021-7 2009 In fact, nuclear-localized CRMP3 co-localized with vimentin during glutamate-induced excitotoxicity. Glutamic Acid 67-76 vimentin Homo sapiens 51-59 19578386-0 2009 Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression. Silybin 0-9 vimentin Homo sapiens 83-91 19578386-11 2009 Furthermore, the expression of vimentin and MMP-2, but not MMP-9 or uPA, was down-regulated in a dose- and time-dependent manner after treatment of silibinin. Silybin 148-157 vimentin Homo sapiens 31-39 19578386-12 2009 CONCLUSION: This study shows that silibinin could inhibit the invasion, motility and migration of ARCaP(M) cells via down-regulation of vimentin and MMP-2 and therefore may be a promising agent against prostate cancer bone metastasis. Silybin 34-43 vimentin Homo sapiens 136-144 20222471-5 2009 Immunofluorescence and Western blotting showed that surfactin significantly suppressed the expression of vimentin, induced the alpha-tubulin depolymerization and rearrangement and then the skeleton system of the cells changed dramatically. surfactin peptide 52-61 vimentin Homo sapiens 105-113 19681904-3 2009 Here, we found that tamoxifen-resistant (TAMR)-MCF-7 cells had undergone EMT, as evidenced by mesenchymal-like cell shape, downregulation of basal E-cadherin expression, and overexpression of N-cadherin and vimentin, as well as increased Snail transcriptional activity and protein expression. Tamoxifen 20-29 vimentin Homo sapiens 207-215 19564157-6 2009 The treatment of THP-1-derived macrophages with calcium ionophore A23187 generated vimentin deimination and resulted in the disruption of vimentin filament organization. Calcium 48-55 vimentin Homo sapiens 83-91 19564157-6 2009 The treatment of THP-1-derived macrophages with calcium ionophore A23187 generated vimentin deimination and resulted in the disruption of vimentin filament organization. Calcium 48-55 vimentin Homo sapiens 138-146 19564157-6 2009 The treatment of THP-1-derived macrophages with calcium ionophore A23187 generated vimentin deimination and resulted in the disruption of vimentin filament organization. Calcimycin 66-72 vimentin Homo sapiens 83-91 19564157-6 2009 The treatment of THP-1-derived macrophages with calcium ionophore A23187 generated vimentin deimination and resulted in the disruption of vimentin filament organization. Calcimycin 66-72 vimentin Homo sapiens 138-146 19666588-7 2009 We confirmed an increased expression of mesenchymal markers, including vimentin (VIM) in cytokeratin-positive epithelial cells metalloproteinase 2 (MMP2), in two separate sets of postletrozole vs. pretreatment specimens. postletrozole 179-192 vimentin Homo sapiens 81-84 19654291-4 2009 We found that the expression of miR-200b, miR-200c, let-7b, let-7c, let-7d, and let-7e was significantly down-regulated in gemcitabine-resistant cells, which showed EMT characteristics such as elongated fibroblastoid morphology, lower expression of epithelial marker E-cadherin, and higher expression of mesenchymal markers such as vimentin and ZEB1. gemcitabine 123-134 vimentin Homo sapiens 332-340 19654291-5 2009 Moreover, we found that reexpression of miR-200 by transfection studies or treatment of gemcitabine-resistant cells with either DIM or isoflavone resulted in the down-regulation of ZEB1, slug, and vimentin, which was consistent with morphologic reversal of EMT phenotype leading to epithelial morphology. mir-200 40-47 vimentin Homo sapiens 197-205 19654291-5 2009 Moreover, we found that reexpression of miR-200 by transfection studies or treatment of gemcitabine-resistant cells with either DIM or isoflavone resulted in the down-regulation of ZEB1, slug, and vimentin, which was consistent with morphologic reversal of EMT phenotype leading to epithelial morphology. gemcitabine 88-99 vimentin Homo sapiens 197-205 19654291-5 2009 Moreover, we found that reexpression of miR-200 by transfection studies or treatment of gemcitabine-resistant cells with either DIM or isoflavone resulted in the down-regulation of ZEB1, slug, and vimentin, which was consistent with morphologic reversal of EMT phenotype leading to epithelial morphology. 3,3'-diindolylmethane 128-131 vimentin Homo sapiens 197-205 19654291-5 2009 Moreover, we found that reexpression of miR-200 by transfection studies or treatment of gemcitabine-resistant cells with either DIM or isoflavone resulted in the down-regulation of ZEB1, slug, and vimentin, which was consistent with morphologic reversal of EMT phenotype leading to epithelial morphology. Isoflavones 135-145 vimentin Homo sapiens 197-205 19617759-3 2009 The methylation status of the methylguanine DNA methyltransferase, human Mut L homolog-1, and vimentin promoter in bisulfite-modified DNA was investigated in a blinded manner by methylation-specific polymerase chain reaction with primer pairs designed to amplify specifically the methylated or unmethylated alleles. hydrogen sulfite 115-124 vimentin Homo sapiens 94-102 19250064-4 2009 To validate our [2H]leucine-based differential proteome analysis for tissues, we successfully compared two known proteins, one up-regulated vimentin and one down-regulated enoyl-CoA hydratase in human renal cancerous tissues versus human normal kidney tissues, which was previously confirmed by other groups using conventional two-dimensional PAGE analysis. Deuterium 17-19 vimentin Homo sapiens 140-148 19137416-0 2009 Low concentration of GA activates a preconditioning response in HepG2 cells during oxidative stress-roles of Hsp90 and vimentin. geldanamycin 21-23 vimentin Homo sapiens 119-127 19137416-6 2009 GA treatment leads to enhanced expression of Hsp90 and vimentin and to inhibition of vimentin protein aggregation. geldanamycin 0-2 vimentin Homo sapiens 55-63 19137416-6 2009 GA treatment leads to enhanced expression of Hsp90 and vimentin and to inhibition of vimentin protein aggregation. geldanamycin 0-2 vimentin Homo sapiens 85-93 19137416-9 2009 However, in contrast to preconditioning, GA treatment obviously changed binding activity of Hsp90 to vimentin cleavages. geldanamycin 41-43 vimentin Homo sapiens 101-109 19574770-9 2009 Western blot analysis was also performed to verify the perturbation of vimentin expression in fibroblast L cells, following stimulation by soluble RCAS1. rcas1 147-152 vimentin Homo sapiens 71-79 19403668-4 2009 Chemical disruption of the vimentin network with acrylamide, intermediate filament bundling in cells from a patient with giant axonal neuropathy, and absence of vimentin in fibroblasts from vimentin(-/-) mice severely reduced entry of either strain. Acrylamide 49-59 vimentin Homo sapiens 27-35 19375111-10 2009 Immunostaining for alpha-smooth muscle actin and vimentin displayed a myofibroblastic invasion in dextranomer/hyaluronic acid. dextranomer 98-110 vimentin Homo sapiens 49-57 19375111-10 2009 Immunostaining for alpha-smooth muscle actin and vimentin displayed a myofibroblastic invasion in dextranomer/hyaluronic acid. Hyaluronic Acid 110-125 vimentin Homo sapiens 49-57 19169269-5 2009 We found that iptakalim could inhibit the proliferation of human PASMCs partly by affecting the expression of Hsp60, vimentin, nucleoporin P54 (NUP54) and Bcl-X(L) by opening the K(ATP) channel. N-(1-methylethyl)-1,1,2-trimethylpropylamine 14-23 vimentin Homo sapiens 117-125 19344669-8 2009 The latter was linked to the decreased stiffness of the underlying fibroblasts, as the amount of triton-insoluble vimentin was significantly decreased in DEHP-treated samples. Diethylhexyl Phthalate 154-158 vimentin Homo sapiens 114-122 19243631-8 2009 We examined whether Akt inhibitor phosphatidylinositol ether lipid analogues (PIA) treatment would restore the expression of E-cadherin and beta-catenin, reduce that of Vimentin, and induce the MErT in KB and KOSCC-25B cells using RT-PCR, immunoblotting, immunofluorescence analysis, and in vitro migration assay. phosphatidylinositol ether lipid 34-66 vimentin Homo sapiens 169-177 19243631-14 2009 PIA treatment induced the expression of E-cadherin and beta-catenin, reduce that of Vimentin, restored their epithelial morphology of a polygonal shape, and reduced tumor cell migration in KB and KOSCC-25B cells, which was the corresponding feature of MErT. pia 0-3 vimentin Homo sapiens 84-92 19349876-8 2009 The number of human fibroblastic cells in CSS that were positive for vimentin increased significantly in the 0.26 and 1.3 microg/cm bFGF treatment groups (P < .01). thiocysteine 42-45 vimentin Homo sapiens 69-77 19291697-5 2009 Specific analysis of the phosphorylation state of vimentin in macrophages showed that this protein becomes rapidly phosphorylated in both tyrosine and serine residues upon chemokine stimulation. Tyrosine 138-146 vimentin Homo sapiens 50-58 19291697-5 2009 Specific analysis of the phosphorylation state of vimentin in macrophages showed that this protein becomes rapidly phosphorylated in both tyrosine and serine residues upon chemokine stimulation. Serine 151-157 vimentin Homo sapiens 50-58 19291697-8 2009 While WT macrophages infected with a vimentin mutant resistant to N-terminal serine phosphorylation showed a reduction in transendothelial migration, infection of PI3Kgamma-null macrophages with a vimentin mutant mimicking serine phosphorylation of N-terminal residues rescued the transendothelial migration defect. Serine 77-83 vimentin Homo sapiens 37-45 19018811-5 2009 Expression of vimentin was evaluated in four cases using immunocytochemistry, which was performed on alcohol-fixed material. Alcohols 101-108 vimentin Homo sapiens 14-22 18844224-13 2009 Most importantly, nicotine could induce changes in gene expression consistent with epithelial to mesenchymal transition (EMT), characterized by reduction of epithelial markers like E-cadherin expression, ZO-1 staining and concomitant increase in levels of mesenchymal proteins like vimentin and fibronectin in human breast and lung cancer cells. Nicotine 18-26 vimentin Homo sapiens 282-290 19194051-6 2009 Expression levels of fibronectin, vimentin and CITED1 (Cbp/p300 interacting protein with glutamic acid and aspartic acid rich carboxyl terminal domain) were positively correlated with those of BRAFV600E, suggesting pathophysiological links between activated BRAF and overexpression of these genes. Glutamic Acid 89-102 vimentin Homo sapiens 34-42 19028702-7 2009 Treatment with 3-keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)-cyclopamine induced cancer cell apoptosis, suppressed cell growth, mobility and invasiveness and induced cancer cell dedifferentiation with decreased expression of E-cadherin, cytokeratin 7, Snail, calretinin, vimentin, Bcl-2, caspases, beta1 integrin, MT1-MMP and VEGF. 3-keto-n-(aminoethyl-aminocaproyl-dihydrocinnamoyl)-cyclopamine 15-78 vimentin Homo sapiens 277-285 18559652-3 2008 A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for the reduced catalytic efficiency against certain cephalosporins, including ceftazidime and cefepime. Cephalosporins 138-152 vimentin Homo sapiens 35-38 19404921-3 2009 MATERIALS AND METHODS: Expression of cytokeratin and vimentin was evaluated by immunohistochemistry on paraffin-embedded tissue sections of patients with breast cancer. Paraffin 103-111 vimentin Homo sapiens 53-61 18823434-5 2008 The TACE group showed reactivity for CK7 in 56.3% (45/80) of patients, CK14 in 12.5% (10/80), CK19 in 23.8% (19/80) and vimentin in 6.3% (5/80) of patients. Chlorotrianisene 4-8 vimentin Homo sapiens 120-128 19270731-0 2009 The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network. Serotonin 29-38 vimentin Homo sapiens 83-91 19270731-3 2009 It has been reported that 5HT-stimulation of cells leads to disassembly and spatial reorientation of vimentin filaments. Serotonin 26-29 vimentin Homo sapiens 101-109 19270731-4 2009 METHODOLOGY/PRINCIPAL FINDINGS: We tested the impact of 5HT-stimulation on vimentin-SERT association and found that 5HT-stimulation accelerates the translocation of SERT from the plasma membrane via enhancing the level of association between phosphovimentin and SERT. Serotonin 56-59 vimentin Homo sapiens 75-83 19270731-4 2009 METHODOLOGY/PRINCIPAL FINDINGS: We tested the impact of 5HT-stimulation on vimentin-SERT association and found that 5HT-stimulation accelerates the translocation of SERT from the plasma membrane via enhancing the level of association between phosphovimentin and SERT. Serotonin 116-119 vimentin Homo sapiens 75-83 19270731-4 2009 METHODOLOGY/PRINCIPAL FINDINGS: We tested the impact of 5HT-stimulation on vimentin-SERT association and found that 5HT-stimulation accelerates the translocation of SERT from the plasma membrane via enhancing the level of association between phosphovimentin and SERT. phosphovimentin 242-257 vimentin Homo sapiens 75-83 19270731-11 2009 CONCLUSIONS/SIGNIFICANCE: Based on our findings, we propose that phosphate modification of the SITPET sequence differentially, one at a time exposes the vimentin binding domain on the C-terminus of SERT. Phosphates 65-74 vimentin Homo sapiens 153-161 19270731-12 2009 Conversely, following 5HT stimulation, the association between vimentin-SERT is enhanced which changes the cellular distribution of SERT on an altered vimentin network. Serotonin 22-25 vimentin Homo sapiens 63-71 19270731-12 2009 Conversely, following 5HT stimulation, the association between vimentin-SERT is enhanced which changes the cellular distribution of SERT on an altered vimentin network. Serotonin 22-25 vimentin Homo sapiens 151-159 18612815-1 2008 In this research we aimed to investigate the interactions between growth factors (GFs) and dexamethasone (DEX) on cytoskeletal proteins GFAP and vimentin (VIM) expression under different experimental conditions. Dexamethasone 91-104 vimentin Homo sapiens 145-153 18612815-1 2008 In this research we aimed to investigate the interactions between growth factors (GFs) and dexamethasone (DEX) on cytoskeletal proteins GFAP and vimentin (VIM) expression under different experimental conditions. Dexamethasone 91-104 vimentin Homo sapiens 155-158 18612815-1 2008 In this research we aimed to investigate the interactions between growth factors (GFs) and dexamethasone (DEX) on cytoskeletal proteins GFAP and vimentin (VIM) expression under different experimental conditions. Dexamethasone 106-109 vimentin Homo sapiens 145-153 18612815-1 2008 In this research we aimed to investigate the interactions between growth factors (GFs) and dexamethasone (DEX) on cytoskeletal proteins GFAP and vimentin (VIM) expression under different experimental conditions. Dexamethasone 106-109 vimentin Homo sapiens 155-158 18612815-5 2008 VIM expression was instead significantly reduced after GFs addition in the last 24 h of 60 h DEX treatment, respect to control DEX-pretreated ones. Dexamethasone 93-96 vimentin Homo sapiens 0-3 18612815-5 2008 VIM expression was instead significantly reduced after GFs addition in the last 24 h of 60 h DEX treatment, respect to control DEX-pretreated ones. Dexamethasone 127-130 vimentin Homo sapiens 0-3 18848541-4 2008 The precursor forms as well as polymerized (filamentous) vimentin are found in the cells in a dynamic equilibrium characterized by the turnover of the subunits within the polymer and the movement of the smaller precursors. Polymers 31-38 vimentin Homo sapiens 57-65 18957515-5 2008 A "cysteine shotgun" method of labeling the in situ proteome reveals differences in assembly or conformation of several abundant cytoskeletal proteins, including vimentin, filamin and myosin. Cysteine 3-11 vimentin Homo sapiens 162-170 18853328-2 2008 At 33 degrees C in DMEM/10% FCS, cells proliferated, were extensively expressing the neural progenitor cell markers nestin and vimentin contrary to neuronal markers. dmem 19-23 vimentin Homo sapiens 127-135 18650485-4 2008 Treatment with Y27632-lysozyme substantially inhibited ischemia/reperfusion-induced tubular damage, indicated by reduced staining of the dedifferentiation markers kidney injury molecule 1 and vimentin, and increased E-cadherin relative to controls. Y 27632 15-21 vimentin Homo sapiens 192-200 18806271-3 2008 At 2 s after initiation of assembly reaction at pH 7.2 and 150 mM NaCl, all the vimentin mutants formed so-called unit-length filaments (ULFs) that were slightly larger than ULFs of wild-type vimentin. Sodium Chloride 66-70 vimentin Homo sapiens 80-88 18541537-4 2008 Adenovirus-mediated delivery of the NFAT inhibitor, VIVIT, suppressed the IL-1beta-dependent induction of several inflammatory mediators and/or markers of astrocyte activation, including tumor necrosis factor alpha, granulocyte/macrophage colony-stimulating factor, and vimentin. NFAT Inhibitor 52-57 vimentin Homo sapiens 187-278 18559652-3 2008 A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for the reduced catalytic efficiency against certain cephalosporins, including ceftazidime and cefepime. Ceftazidime 164-175 vimentin Homo sapiens 35-38 18559652-3 2008 A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for the reduced catalytic efficiency against certain cephalosporins, including ceftazidime and cefepime. Cefepime 180-188 vimentin Homo sapiens 35-38 19035249-15 2008 After the ATRA treatment, cells were stained strongly positive, strongly positive and moderately positive by NSE, vimentin and GFAP antibodies, respectively. Tretinoin 10-14 vimentin Homo sapiens 114-122 18407667-9 2008 Interestingly, vimentin, the IF characteristic of leukocytes, is one of the major proteins recognized by SP-A in protein extracts of U937 cells after PMA-induced differentiation of this monocytic cell line. Tetradecanoylphorbol Acetate 150-153 vimentin Homo sapiens 15-23 18046501-0 2008 Up-regulation of vimentin expression in low-density malignant glioma cells as immediate and late effects under irradiation and temozolomide treatment. Temozolomide 127-139 vimentin Homo sapiens 17-25 18046501-11 2008 Significant increase in vimentin expression levels was detected particularly in low-density cell cultures under durable treatment with constant concentration levels of temezolomide. temezolomide 168-180 vimentin Homo sapiens 24-32 18448838-3 2008 The natural degradation product of glucose, methylglyoxal, was able to induce the aggregation of vimentin. Glucose 35-42 vimentin Homo sapiens 97-105 18587733-6 2008 AmA-HSA-Glu 3.86% and 1.36% induced a significantly higher increase in vimentin and Type I collagen mRNA expression than AmA-HSA-Ico (p<0.0001). Glucose 8-11 vimentin Homo sapiens 71-79 18448838-5 2008 Furthermore, we found that the protein vimentin was modified, not only by CML and CEL, but also by pentosidine and pyrraline. pentosidine 99-110 vimentin Homo sapiens 39-47 18326534-3 2008 Citrullinated vimentin isoforms were visualized by a combination of anti-modified citrulline (AMC) staining and anti-vimentin detections (V9, H-84). Citrulline 82-92 vimentin Homo sapiens 14-22 18326534-3 2008 Citrullinated vimentin isoforms were visualized by a combination of anti-modified citrulline (AMC) staining and anti-vimentin detections (V9, H-84). 7-amino-4-methylcoumarin 94-97 vimentin Homo sapiens 14-22 18448838-3 2008 The natural degradation product of glucose, methylglyoxal, was able to induce the aggregation of vimentin. Pyruvaldehyde 44-57 vimentin Homo sapiens 97-105 18448838-5 2008 Furthermore, we found that the protein vimentin was modified, not only by CML and CEL, but also by pentosidine and pyrraline. 2-formyl-5-(hydroxymethyl)pyrrole-1-norleucine 115-124 vimentin Homo sapiens 39-47 18381893-6 2008 Conversely, inhibition of miR-200 reduced E-cadherin expression, increased expression of Vimentin, and induced EMT. mir-200 26-33 vimentin Homo sapiens 89-97 17881458-9 2007 Both synthetic MEK1/2 inhibitors U0126 and Cl-1040, when used at concentrations which inhibit ERK1/2 phosphorylation but not ERK5 phosphorylation, restored N-cadherin expression in the presence of OSM, inhibited basal claudin-2 expression, but did not affect either basal or OSM-inhibited E-cadherin expression or OSM-induced expression of collagen type I and vimentin. U 0126 33-38 vimentin Homo sapiens 340-368 18224299-3 2008 To our knowledge, this is the first report of VIM-DBS-induced reversible hypogeusia along with retroinsular cortical deactivation under effective VIM stimulation measured with 18-fluorodexoglucose positron emission tomography. 18-fluorodexoglucose 176-196 vimentin Homo sapiens 46-49 18224299-3 2008 To our knowledge, this is the first report of VIM-DBS-induced reversible hypogeusia along with retroinsular cortical deactivation under effective VIM stimulation measured with 18-fluorodexoglucose positron emission tomography. 18-fluorodexoglucose 176-196 vimentin Homo sapiens 146-149 18286686-9 2008 Overexpression of Slug in OE33 mediated E-cadherin repression and induced the mesenchymal markers vimentin and fibronectin. oe33 26-30 vimentin Homo sapiens 98-106 18270854-8 2008 The anti-Sa antibody has been identified a decade ago; however, recent studies confirmed that anti-Sa is directed against citrullinated vimentin, hence it is a new member of the family of ACPAs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 9-11 vimentin Homo sapiens 136-144 18270854-9 2008 The newly developed anti-mutated citrullinated vimentin (anti-MCV) assay has similar diagnostic performance than the anti-CCP2 ELISA; however, the diagnostic spectrum of the anti-MCV test is somewhat different from that of anti-CCP2. citrullinated 33-46 vimentin Homo sapiens 47-55 18683670-3 2008 Using fluorescence microscopy, immunoblotting and microflorimetry we show that treatment with zinc sulfate affected motility, invasiveness, cytoskeletal integrity and expression of selected markers (E-cadherin, catenin, vimentin, tubulin and actin) of invasive SW480 colon tumor cells. Zinc Sulfate 94-106 vimentin Homo sapiens 220-228 18184460-1 2008 BACKGROUND & OBJECTIVE: Vimentin, a cytoskeleton protein, is involved in regulating the migration and proliferation of cells. Adenosine Monophosphate 12-15 vimentin Homo sapiens 28-36 18163519-1 2008 OBJECTIVE: The Sa autoantigen can be found in inflamed synovium of patients with rheumatoid arthritis (RA), and at least part of the humoral RA-specific anti-Sa response is directed against citrullinated vimentin. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 vimentin Homo sapiens 204-212 19192631-1 2007 In this research we aimed to investigate the interactions between growth factors (GFs) and dexamethasone (DEX) on cytoskeletal proteins GFAP and vimentin (VIM) expression under the following experimental condition: 24h pretreatment with bFGF, subsequent 72h switching in serum-free medium (SFM) and final addition of GFs, only one or more in the last 24h, after a prolonged (60h) DEX treatment. Dexamethasone 91-104 vimentin Homo sapiens 145-153 19192631-1 2007 In this research we aimed to investigate the interactions between growth factors (GFs) and dexamethasone (DEX) on cytoskeletal proteins GFAP and vimentin (VIM) expression under the following experimental condition: 24h pretreatment with bFGF, subsequent 72h switching in serum-free medium (SFM) and final addition of GFs, only one or more in the last 24h, after a prolonged (60h) DEX treatment. Dexamethasone 91-104 vimentin Homo sapiens 155-158 19192631-1 2007 In this research we aimed to investigate the interactions between growth factors (GFs) and dexamethasone (DEX) on cytoskeletal proteins GFAP and vimentin (VIM) expression under the following experimental condition: 24h pretreatment with bFGF, subsequent 72h switching in serum-free medium (SFM) and final addition of GFs, only one or more in the last 24h, after a prolonged (60h) DEX treatment. Dexamethasone 106-109 vimentin Homo sapiens 145-153 19192631-1 2007 In this research we aimed to investigate the interactions between growth factors (GFs) and dexamethasone (DEX) on cytoskeletal proteins GFAP and vimentin (VIM) expression under the following experimental condition: 24h pretreatment with bFGF, subsequent 72h switching in serum-free medium (SFM) and final addition of GFs, only one or more in the last 24h, after a prolonged (60h) DEX treatment. Dexamethasone 106-109 vimentin Homo sapiens 155-158 19192631-1 2007 In this research we aimed to investigate the interactions between growth factors (GFs) and dexamethasone (DEX) on cytoskeletal proteins GFAP and vimentin (VIM) expression under the following experimental condition: 24h pretreatment with bFGF, subsequent 72h switching in serum-free medium (SFM) and final addition of GFs, only one or more in the last 24h, after a prolonged (60h) DEX treatment. Dexamethasone 380-383 vimentin Homo sapiens 155-158 19192631-5 2007 VIM expression was instead significantly reduced after GFs addition in the last 24h of 60h DEX treatment, respect to control DEX-pretreated ones. Dexamethasone 91-94 vimentin Homo sapiens 0-3 19192631-5 2007 VIM expression was instead significantly reduced after GFs addition in the last 24h of 60h DEX treatment, respect to control DEX-pretreated ones. Dexamethasone 125-128 vimentin Homo sapiens 0-3 18426555-6 2008 By immunocytochemistry, we analyzed alterations of vimentin organization in presence of different concentrations of EGCG. epigallocatechin gallate 116-120 vimentin Homo sapiens 51-59 18426555-8 2008 EGCG also inhibited MMP-2 mRNA and protein expression and altered the intermediate filaments of vimentin. epigallocatechin gallate 0-4 vimentin Homo sapiens 96-104 18000741-4 2008 PD98059-exposed ACHN cells showed elongated cell shape with scattering morphology, increase in vimentin expression, loss of beta-catenin junctional localization, stress fiber formation, and increased motility. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 vimentin Homo sapiens 95-103 18230156-0 2008 Retinoic acid reduces human neuroblastoma cell migration and invasiveness: effects on DCX, LIS1, neurofilaments-68 and vimentin expression. Tretinoin 0-13 vimentin Homo sapiens 119-127 18468248-4 2008 An immunocytochemical study of the clonal lines indicated that clonal line CL-11 expressed liver epithelial cell markers CK14, vimentin, CK18, and BD-1. cl-11 75-80 vimentin Homo sapiens 127-135 17927688-7 2007 In addition, rottlerin and FCCP also induced degradation of connexin46, filensin, vimentin and CP49. rottlerin 13-22 vimentin Homo sapiens 82-90 17881458-9 2007 Both synthetic MEK1/2 inhibitors U0126 and Cl-1040, when used at concentrations which inhibit ERK1/2 phosphorylation but not ERK5 phosphorylation, restored N-cadherin expression in the presence of OSM, inhibited basal claudin-2 expression, but did not affect either basal or OSM-inhibited E-cadherin expression or OSM-induced expression of collagen type I and vimentin. 7,8,9-trimethoxy-4,5-dihydro-1H-benzo[g]indazole 43-50 vimentin Homo sapiens 340-368 17567584-3 2007 We were able to identify the intermediate filament vimentin as the major target for the AGE modification N(epsilon)-(carboxymethyl)lysine (CML) in primary human fibroblasts. N(6)-carboxymethyllysine 105-137 vimentin Homo sapiens 51-59 17927688-7 2007 In addition, rottlerin and FCCP also induced degradation of connexin46, filensin, vimentin and CP49. Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone 27-31 vimentin Homo sapiens 82-90 17576011-3 2007 Fibronectin-coated poly(di-methyl siloxane) substrates with line-grating (600nm ridges with 600nm spacing and 600+/-150nm feature height) induced hESC alignment and elongation, mediated the organization of cytoskeletal components including actin, vimentin, and alpha-tubulin, and reduced proliferation. baysilon 19-43 vimentin Homo sapiens 247-255 17567584-3 2007 We were able to identify the intermediate filament vimentin as the major target for the AGE modification N(epsilon)-(carboxymethyl)lysine (CML) in primary human fibroblasts. N(6)-carboxymethyllysine 139-142 vimentin Homo sapiens 51-59 17567584-5 2007 Glycation of vimentin was predominantly detected at lysine residues located at the linker regions using nanoLC-ESI-MS/MS. Lysine 52-58 vimentin Homo sapiens 13-21 17663720-9 2007 The histone deacetylase (HDAC) inhibitor TSA enhances vimentin gene expression requiring the proximal promoter region including GC-box 1, a known Sp1/Sp3 binding site. trichostatin A 41-44 vimentin Homo sapiens 54-62 17663720-10 2007 Chromatin immunoprecipitation (ChIP) assays document an increase in the acetylation status of histone H3 on the endogenous vimentin gene concomitant with TSA treatment. trichostatin A 154-157 vimentin Homo sapiens 123-131 17611988-2 2007 However, antibodies to several other citrulline-containing proteins, including citrullinated fibrin and vimentin, have been detected in patients with RA, suggesting that citrulline is an essential constituent of autoantigens for RA-specific autoantibodies. Citrulline 170-180 vimentin Homo sapiens 104-112 17507370-8 2007 By combining a new O-GlcNAc peptide enrichment method and beta-elimination followed by Michael addition with DTT, we also mapped the O-GlcNAc site (Ser-55) of vimentin, which showed an apparent increase of O-GlcNAcylation upon GSK-3 inhibition. Dithiothreitol 109-112 vimentin Homo sapiens 159-167 17507370-8 2007 By combining a new O-GlcNAc peptide enrichment method and beta-elimination followed by Michael addition with DTT, we also mapped the O-GlcNAc site (Ser-55) of vimentin, which showed an apparent increase of O-GlcNAcylation upon GSK-3 inhibition. Serine 148-151 vimentin Homo sapiens 159-167 17262792-11 2007 Immunohistochemical analysis showed PBs" positive reaction on vimentin, CD45R0, and LCA markers, while in their vicinity, as well as inside them, numerous T-cells were observed. pbs 36-39 vimentin Homo sapiens 62-70 17185354-13 2007 Metaplasia could be induced from the stromal compartment alone and vimentin expression co-localised with CK8/18 at 24 h, which separated into CK8/18-positive glands and vimentin-positive stroma by 48 h. Citral-treated Barrett"s oesophagus led to phenotypic and immunohistochemical characteristics of SE, which was independent of proliferation. citral 203-209 vimentin Homo sapiens 67-75 17552912-0 2007 Selection of vimentin-specific antibodies from the HuCAL phage display library by subtractive panning on formalin-fixed, paraffin-embedded tissue. Formaldehyde 105-113 vimentin Homo sapiens 13-21 17552912-0 2007 Selection of vimentin-specific antibodies from the HuCAL phage display library by subtractive panning on formalin-fixed, paraffin-embedded tissue. Paraffin 121-129 vimentin Homo sapiens 13-21 17314023-1 2007 Long-term culture of phorbol ester (TPA)-differentiated and growth-arrested human U937 leukemia cells was associated with expression of c-jun transcription factors and vimentin intermediate filaments until the cells entered a retrodifferentiation program. Phorbol Esters 21-34 vimentin Homo sapiens 168-176 17314023-1 2007 Long-term culture of phorbol ester (TPA)-differentiated and growth-arrested human U937 leukemia cells was associated with expression of c-jun transcription factors and vimentin intermediate filaments until the cells entered a retrodifferentiation program. Tetradecanoylphorbol Acetate 36-39 vimentin Homo sapiens 168-176 17541031-6 2007 We confirmed that increased protein expression of vimentin combined with the loss of E-cadherin, claudin 4, and claudin 7 by immunoblotting was associated with gefitinib resistance in both HNSCC and NSCLC cell lines. Gefitinib 160-169 vimentin Homo sapiens 50-58 16889625-4 2007 The C terminus (amino acids 234-453) encodes a 14-3-3-dependent ADP-ribosyltransferase domain which transfers ADP-ribose from NAD onto substrates such as the Ras GTPases and vimentin. Adenosine Diphosphate Ribose 110-120 vimentin Homo sapiens 174-182 21357022-0 2007 Preparation and Microinjection of x-Rhodamine-Labeled Vimentin. x-rhodamine 34-45 vimentin Homo sapiens 54-62 17224050-7 2007 Site directed mutation also reveals that amino acid residues Gly 70 and Val 72 are important in the VP2-vimentin association. Glycine 61-64 vimentin Homo sapiens 104-112 17224050-7 2007 Site directed mutation also reveals that amino acid residues Gly 70 and Val 72 are important in the VP2-vimentin association. Valine 72-75 vimentin Homo sapiens 104-112 16997882-0 2007 Dissociation of Crk-associated substrate from the vimentin network is regulated by p21-activated kinase on ACh activation of airway smooth muscle. Acetylcholine 107-110 vimentin Homo sapiens 50-58 16997882-4 2007 In the present study, ACh stimulation of tracheal smooth muscle strips increased the ratio of soluble to insoluble vimentin (an index of vimentin disassembly) in association with force development. Acetylcholine 22-25 vimentin Homo sapiens 115-123 16997882-4 2007 In the present study, ACh stimulation of tracheal smooth muscle strips increased the ratio of soluble to insoluble vimentin (an index of vimentin disassembly) in association with force development. Acetylcholine 22-25 vimentin Homo sapiens 137-145 16997882-5 2007 ACh activation also induced vimentin phosphorylation at Ser(56) as assessed by immunoblot analysis. Acetylcholine 0-3 vimentin Homo sapiens 28-36 16997882-5 2007 ACh activation also induced vimentin phosphorylation at Ser(56) as assessed by immunoblot analysis. Serine 56-59 vimentin Homo sapiens 28-36 16997882-8 2007 The ACh-elicited decrease in CAS distribution in cytoskeletal vimentin was attenuated by the downregulation of p21-activated kinase (PAK) 1 with antisense oligodeoxynucleotides. Acetylcholine 4-7 vimentin Homo sapiens 62-70 16997882-9 2007 Vimentin phosphorylation at this residue, the ratio of soluble to insoluble vimentin, and active force in smooth muscle strips induced by ACh were also reduced in PAK-depleted tissues. Acetylcholine 138-141 vimentin Homo sapiens 0-8 16997882-10 2007 These results suggest that PAK may regulate CAS release from the vimentin intermediate filaments by mediating vimentin phosphorylation at Ser(56) and the transition of cytoskeletal vimentin to soluble vimentin. Serine 138-141 vimentin Homo sapiens 110-118 16997882-10 2007 These results suggest that PAK may regulate CAS release from the vimentin intermediate filaments by mediating vimentin phosphorylation at Ser(56) and the transition of cytoskeletal vimentin to soluble vimentin. Serine 138-141 vimentin Homo sapiens 110-118 16997882-10 2007 These results suggest that PAK may regulate CAS release from the vimentin intermediate filaments by mediating vimentin phosphorylation at Ser(56) and the transition of cytoskeletal vimentin to soluble vimentin. Serine 138-141 vimentin Homo sapiens 110-118 16997882-11 2007 The PAK-mediated dissociation of CAS from the vimentin network may participate in the cellular processes that affect active force development during ACh activation of tracheal smooth muscle tissues. Acetylcholine 149-152 vimentin Homo sapiens 46-54 16920414-8 2007 Local delivery of sirolimus during angioplasty attenuated the expression of structural proteins that included lamin A, vimentin, alpha-1-antitrypsin, and alpha-actin. Sirolimus 18-27 vimentin Homo sapiens 119-127 17374985-7 2007 Genes we found to increase with selenomethionine treatment include KLK6, ATOX1, SGK, GJB2, DAP-1, PLAU, VIM, DPYSL2, STC2 and PXN. Selenomethionine 32-48 vimentin Homo sapiens 104-107 16889625-4 2007 The C terminus (amino acids 234-453) encodes a 14-3-3-dependent ADP-ribosyltransferase domain which transfers ADP-ribose from NAD onto substrates such as the Ras GTPases and vimentin. NAD 126-129 vimentin Homo sapiens 174-182 17237287-6 2007 Gefitinib-sensitive cells generally expressed higher levels of E-cadherin and lower levels of vimentin than the gefitinib-resistant cells, but these correlations were not perfect, suggesting that these markers of epithelial-mesenchymal transition cannot be used by themselves to prospectively predict EGFR-dependent growth. Gefitinib 0-9 vimentin Homo sapiens 94-102 17083913-4 2006 The binding sites of the IbeA-vimentin interaction are located in the 271-370 residue region of IbeA and the vimentin head domain. ibea 25-29 vimentin Homo sapiens 30-38 17083913-4 2006 The binding sites of the IbeA-vimentin interaction are located in the 271-370 residue region of IbeA and the vimentin head domain. ibea 25-29 vimentin Homo sapiens 109-117 17083913-4 2006 The binding sites of the IbeA-vimentin interaction are located in the 271-370 residue region of IbeA and the vimentin head domain. ibea 96-100 vimentin Homo sapiens 30-38 17083913-5 2006 The regulatory protease factor Xa is able to cleave IbeA between R297 and K298 residues, and this cleavage abolishes the IbeA-vimentin interaction. ibea 52-56 vimentin Homo sapiens 126-134 17083913-5 2006 The regulatory protease factor Xa is able to cleave IbeA between R297 and K298 residues, and this cleavage abolishes the IbeA-vimentin interaction. ibea 121-125 vimentin Homo sapiens 126-134 16940012-4 2006 Considering the role that these intermediate filaments play in the anchorage and cellular organization of myocardiocytes, the decrease of desmin and vimentin observed in cells treated with clofibric acid may be partially responsible for the adverse effects observed in patients. Clofibric Acid 189-203 vimentin Homo sapiens 149-157 17046786-3 2006 Pull-down and ELISA experiments revealed robust calcium-dependent binding of pErk to the second coiled-coil domain of vimentin, with observed affinities of binding increasing from 180 nM at 0.1 microM calcium to 15 nM at 10 microM calcium. Calcium 48-55 vimentin Homo sapiens 118-126 17046786-3 2006 Pull-down and ELISA experiments revealed robust calcium-dependent binding of pErk to the second coiled-coil domain of vimentin, with observed affinities of binding increasing from 180 nM at 0.1 microM calcium to 15 nM at 10 microM calcium. Calcium 201-208 vimentin Homo sapiens 118-126 17046786-3 2006 Pull-down and ELISA experiments revealed robust calcium-dependent binding of pErk to the second coiled-coil domain of vimentin, with observed affinities of binding increasing from 180 nM at 0.1 microM calcium to 15 nM at 10 microM calcium. Calcium 201-208 vimentin Homo sapiens 118-126 16990256-0 2006 Critical role of vimentin phosphorylation at Ser-56 by p21-activated kinase in vimentin cytoskeleton signaling. Serine 45-48 vimentin Homo sapiens 17-25 16990256-0 2006 Critical role of vimentin phosphorylation at Ser-56 by p21-activated kinase in vimentin cytoskeleton signaling. Serine 45-48 vimentin Homo sapiens 79-87 16990256-5 2006 Expression of mutant S56A vimentin in cells inhibited the increase in phosphorylation at Ser-56 and in the ratios of soluble to insoluble vimentin (an index of vimentin disassembly) and the dissociation of CAS from cytoskeletal vimentin in response to 5-HT activation compared with cells expressing wild-type vimentin. Serine 89-92 vimentin Homo sapiens 26-34 16990256-7 2006 Expression of mutant S56A vimentin depressed PAK phosphorylation at Thr-423 induced by 5-HT. Threonine 68-71 vimentin Homo sapiens 26-34 16990256-9 2006 Our results suggest that vimentin phosphorylation at Ser-56 may inversely regulate PAK activation possibly via the increase in the amount of soluble CAS upon agonist stimulation of smooth muscle cells. Serine 53-56 vimentin Homo sapiens 25-33 17073495-1 2006 In the present work, copolymers of vinylphosphonic acid and 4-vinilyimidazole (poly(4-VIm-co-VPA)) were found to be substrates favoring the precipitation of nanohydroxyapatite (HAP) crystals from stable supersaturated solutions at pH 7.4 and 37 degrees C. Deposition kinetics were studied by the constant composition technique. copolymers 21-31 vimentin Homo sapiens 86-89 17073495-1 2006 In the present work, copolymers of vinylphosphonic acid and 4-vinilyimidazole (poly(4-VIm-co-VPA)) were found to be substrates favoring the precipitation of nanohydroxyapatite (HAP) crystals from stable supersaturated solutions at pH 7.4 and 37 degrees C. Deposition kinetics were studied by the constant composition technique. vinylphosphonic acid 35-55 vimentin Homo sapiens 86-89 17073495-1 2006 In the present work, copolymers of vinylphosphonic acid and 4-vinilyimidazole (poly(4-VIm-co-VPA)) were found to be substrates favoring the precipitation of nanohydroxyapatite (HAP) crystals from stable supersaturated solutions at pH 7.4 and 37 degrees C. Deposition kinetics were studied by the constant composition technique. 4-vinilyimidazole 60-77 vimentin Homo sapiens 86-89 17073495-1 2006 In the present work, copolymers of vinylphosphonic acid and 4-vinilyimidazole (poly(4-VIm-co-VPA)) were found to be substrates favoring the precipitation of nanohydroxyapatite (HAP) crystals from stable supersaturated solutions at pH 7.4 and 37 degrees C. Deposition kinetics were studied by the constant composition technique. nanohydroxyapatite 157-175 vimentin Homo sapiens 86-89 17016644-5 2006 Furthermore, upregulation of vimentin by treatment with SDF-1 was impaired by phosphatidylinositol 3 kinase (PI3K) inhibitor Wortmannin, but not by mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor U0126. Wortmannin 125-135 vimentin Homo sapiens 29-37 17016644-5 2006 Furthermore, upregulation of vimentin by treatment with SDF-1 was impaired by phosphatidylinositol 3 kinase (PI3K) inhibitor Wortmannin, but not by mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor U0126. U 0126 229-234 vimentin Homo sapiens 29-37 17050693-4 2006 While a vimentin solution in 5 mM Tris.HCl (pH 8.4) contains predominantly tetramers, addition of 20 mM NaCl induces further lateral assembly evidenced by the shift of the sedimentation coefficient and yields a distinct octameric intermediate. Tromethamine 34-38 vimentin Homo sapiens 8-16 17006627-4 2006 A cascade of events leading to apoptotic mitochondrial "intrinsic" pathway was observed in treated cells: (1) dephosphorylation of BAD serine136; (2) BAD dissociation from 14-3-3 followed by its association with BCL-XL; (3) cytochrome c release; (4) caspase-3 activation, and (5) cleavage of vimentin. serine136 135-144 vimentin Homo sapiens 292-300 16571866-2 2006 Tracheal smooth muscle strips were loaded with antisense oligonucleotides (ODNs) against vimentin and then cultured for 2 days to allow for protein degradation. Oligonucleotides 57-73 vimentin Homo sapiens 89-97 16571866-4 2006 Force development in response to ACh stimulation or KCl depolarization was lower in vimentin-deficient tissues than in vimentin sense ODN- or non-ODN-treated muscle strips. Acetylcholine 33-36 vimentin Homo sapiens 84-92 16571866-4 2006 Force development in response to ACh stimulation or KCl depolarization was lower in vimentin-deficient tissues than in vimentin sense ODN- or non-ODN-treated muscle strips. Acetylcholine 33-36 vimentin Homo sapiens 119-127 16571866-4 2006 Force development in response to ACh stimulation or KCl depolarization was lower in vimentin-deficient tissues than in vimentin sense ODN- or non-ODN-treated muscle strips. Potassium Chloride 52-55 vimentin Homo sapiens 84-92 16912072-3 2006 We find that treatment of cells with Brefeldin A, an inhibitor of specific stages of membrane transport, causes changes in the organization of vimentin filaments. Brefeldin A 37-48 vimentin Homo sapiens 143-151 16912072-7 2006 Brefeldin A-induced changes in vimentin architecture are probably mediated through its effects on ADP-ribosylation factor 1 (ARF1). Brefeldin A 0-11 vimentin Homo sapiens 31-39 16876394-7 2006 Vimentin intermediate filaments were disrupted in high-density monolayer articular chondrocyte cultures using acrylamide for 7 days. Acrylamide 110-120 vimentin Homo sapiens 0-8 17050693-4 2006 While a vimentin solution in 5 mM Tris.HCl (pH 8.4) contains predominantly tetramers, addition of 20 mM NaCl induces further lateral assembly evidenced by the shift of the sedimentation coefficient and yields a distinct octameric intermediate. Hydrochloric Acid 39-42 vimentin Homo sapiens 8-16 17050693-4 2006 While a vimentin solution in 5 mM Tris.HCl (pH 8.4) contains predominantly tetramers, addition of 20 mM NaCl induces further lateral assembly evidenced by the shift of the sedimentation coefficient and yields a distinct octameric intermediate. Sodium Chloride 104-108 vimentin Homo sapiens 8-16 17064527-13 2006 CONCLUSION: Citrullinated vimentin is closely correlated with Sa antigen. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 62-64 vimentin Homo sapiens 26-34 16986488-9 2006 Immunohistochemical staining with avidin-biotin was performed by using cytokeratin, vimentin, SMA, p53, Bcl 2, EMA, and CD10. avidin-biotin 34-47 vimentin Homo sapiens 84-92 16629905-1 2006 In astrocytes, the PGF(2alpha) or ionomycin treatment induces the phosphorylation at Ser38 and Ser82 of vimentin, a type III intermediate filament, by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). Prostaglandins F 19-22 vimentin Homo sapiens 104-112 16792722-9 2006 The CAFs showed positive staining for vimentin, alpha-smooth muscle actin and matrix metalloproteinases-2. cafs 4-8 vimentin Homo sapiens 38-46 16629905-1 2006 In astrocytes, the PGF(2alpha) or ionomycin treatment induces the phosphorylation at Ser38 and Ser82 of vimentin, a type III intermediate filament, by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). Ionomycin 34-43 vimentin Homo sapiens 104-112 16629905-6 2006 The repetitive treatment by ionomycin at a short interval resulted in the sustained elevation of Ser82 phosphorylation, leading to the marked disassembly of vimentin filaments. Ionomycin 28-37 vimentin Homo sapiens 157-165 17235376-9 2006 Heroin also significantly decreased protein expression for proliferating cell nuclear antigen, proteasome beta 6 subunit, tropomyosin 3, laminin receptor 1, tubulin alpha 6, vimentin, EF hand domain family member D2, Tumor protein D54 (hD54), ATP synthase, H+ transporting, mitochondrial F1 complex and ribosomal protein S14. Heroin 0-6 vimentin Homo sapiens 174-182 16365157-6 2006 By monitoring intracellular expression of vimentin and lamin B1 during SA, we found that these two proteins were cleaved and that such cleavage was reversed by the pan caspase inhibitor N-benzyloxy-carbonyl-V-A-D-O-methylfluoromethyl ketone (z-VAD-fmk). sa 71-73 vimentin Homo sapiens 42-50 16365157-6 2006 By monitoring intracellular expression of vimentin and lamin B1 during SA, we found that these two proteins were cleaved and that such cleavage was reversed by the pan caspase inhibitor N-benzyloxy-carbonyl-V-A-D-O-methylfluoromethyl ketone (z-VAD-fmk). n-benzyloxy-carbonyl-v-a-d-o-methylfluoromethyl ketone 186-240 vimentin Homo sapiens 42-50 16365157-6 2006 By monitoring intracellular expression of vimentin and lamin B1 during SA, we found that these two proteins were cleaved and that such cleavage was reversed by the pan caspase inhibitor N-benzyloxy-carbonyl-V-A-D-O-methylfluoromethyl ketone (z-VAD-fmk). benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 242-251 vimentin Homo sapiens 42-50 16365157-9 2006 Addition of z-VAD-fmk significantly decreased the cell surface expression of vimentin and lamin B1 during SA. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 12-21 vimentin Homo sapiens 77-85 16391805-3 2006 In this study, we showed that Tet Off-induced expression of Snail or SIP1, and treatment with TGF-beta1 induced EMT in terms of down-regulation of E-cadherin, and up-regulation of vimentin and MMP-2 expression with morphological changes. tetramethylenedisulfotetramine 30-33 vimentin Homo sapiens 180-188 16445818-5 2006 The OLS showed strong positivity for alpha-smooth muscle actin (alpha-SMA) and vimentin and weak, focal positivity for desmin. N-biotin-C-Co4(mu3-O)4(Py)4(H2O)4-beta-alanine 4-7 vimentin Homo sapiens 79-87 16291835-12 2006 Consistent with these findings, 15d-PGJ2 induced early reorganization of vimentin and tubulin in MC. 15-deoxy-delta(12,14)-prostaglandin J2 32-40 vimentin Homo sapiens 73-81 16291835-13 2006 The cyclopentenone moiety and the presence of cysteine were important for vimentin rearrangement. cyclopentenone 4-18 vimentin Homo sapiens 74-82 16291835-13 2006 The cyclopentenone moiety and the presence of cysteine were important for vimentin rearrangement. Cysteine 46-54 vimentin Homo sapiens 74-82 16328963-0 2006 HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis. geldanamycin 49-61 vimentin Homo sapiens 37-45 16264267-0 2005 Heat shock protein 27 interacts with vimentin and prevents insolubilization of vimentin subunits induced by cadmium. Cadmium 108-115 vimentin Homo sapiens 79-87 16264267-2 2005 In this study, vimentin filaments were morphologically altered, and its soluble subunits were rapidly reduced via cadmium chloride treatment. Cadmium Chloride 114-130 vimentin Homo sapiens 15-23 16264267-4 2005 In order to determine whether MAPKs were involved in this cadmium-induced soluble vimentin disappearance, we applied MAPK-specific inhibitors (PD98059, SP600125, SB203580). Cadmium 58-65 vimentin Homo sapiens 82-90 16264267-9 2005 HSP27-overexpressing cells prevented morphological alterations of the vimentin filaments, as well as reductions of soluble vimentin, in the cadmium-treated cells. Cadmium 140-147 vimentin Homo sapiens 123-131 16264267-10 2005 Moreover, HSP27 antisense oligonucleotide augmented these cadmium-induced changes in vimentin. Oligonucleotides 26-41 vimentin Homo sapiens 85-93 16264267-10 2005 Moreover, HSP27 antisense oligonucleotide augmented these cadmium-induced changes in vimentin. Cadmium 58-65 vimentin Homo sapiens 85-93 16264267-11 2005 These findings indicate that HSP27 prevents disruption of the vimentin intermediate filament networks and soluble vimentin disappearance, by virtue of its physical interaction with vimentin in cadmium-treated SK-N-SH cells. Cadmium 193-200 vimentin Homo sapiens 62-70 16264267-11 2005 These findings indicate that HSP27 prevents disruption of the vimentin intermediate filament networks and soluble vimentin disappearance, by virtue of its physical interaction with vimentin in cadmium-treated SK-N-SH cells. Cadmium 193-200 vimentin Homo sapiens 114-122 16264267-11 2005 These findings indicate that HSP27 prevents disruption of the vimentin intermediate filament networks and soluble vimentin disappearance, by virtue of its physical interaction with vimentin in cadmium-treated SK-N-SH cells. Cadmium 193-200 vimentin Homo sapiens 114-122 16264267-11 2005 These findings indicate that HSP27 prevents disruption of the vimentin intermediate filament networks and soluble vimentin disappearance, by virtue of its physical interaction with vimentin in cadmium-treated SK-N-SH cells. sk-n 209-213 vimentin Homo sapiens 114-122 16264267-11 2005 These findings indicate that HSP27 prevents disruption of the vimentin intermediate filament networks and soluble vimentin disappearance, by virtue of its physical interaction with vimentin in cadmium-treated SK-N-SH cells. sk-n 209-213 vimentin Homo sapiens 114-122 16132961-5 2005 In monolayer culture, 90% of the streptozotocin-treated pancreatic cells co-expressed cytokeratin-19 and vimentin at 2 weeks and 60% expressed nestin at 4 weeks. Streptozocin 33-47 vimentin Homo sapiens 105-113 16023194-3 2005 Treatment with Triton-SDS was most effective at removing cell nuclei and intracellular protein (vimentin) from the ACL but affected both the collagen and glycosaminoglycan (GAG) components of the extracellular matrix while increasing the tensile stiffness of the ligament. triton-sds 15-25 vimentin Homo sapiens 96-104 16270034-6 2005 Finally, introduction of ectopic wild-type vimentin is shown to promote cell motility in a PKCepsilon-dependent manner; alanine substitutions in PKC (controlled) sites on vimentin abolishes the ability of vimentin to induce cell migration, whereas the substitution of these sites with acidic residues enables vimentin to rescue motility of PKCepsilon null cells. Alanine 120-127 vimentin Homo sapiens 43-51 16270034-6 2005 Finally, introduction of ectopic wild-type vimentin is shown to promote cell motility in a PKCepsilon-dependent manner; alanine substitutions in PKC (controlled) sites on vimentin abolishes the ability of vimentin to induce cell migration, whereas the substitution of these sites with acidic residues enables vimentin to rescue motility of PKCepsilon null cells. Alanine 120-127 vimentin Homo sapiens 171-179 16270034-6 2005 Finally, introduction of ectopic wild-type vimentin is shown to promote cell motility in a PKCepsilon-dependent manner; alanine substitutions in PKC (controlled) sites on vimentin abolishes the ability of vimentin to induce cell migration, whereas the substitution of these sites with acidic residues enables vimentin to rescue motility of PKCepsilon null cells. Alanine 120-127 vimentin Homo sapiens 171-179 16270034-6 2005 Finally, introduction of ectopic wild-type vimentin is shown to promote cell motility in a PKCepsilon-dependent manner; alanine substitutions in PKC (controlled) sites on vimentin abolishes the ability of vimentin to induce cell migration, whereas the substitution of these sites with acidic residues enables vimentin to rescue motility of PKCepsilon null cells. Alanine 120-127 vimentin Homo sapiens 171-179 16260496-5 2005 Plk1 phosphorylated vimentin at approximately 1 mol phosphate/mol substrate, which partly inhibited its filament forming ability, in vitro. Phosphates 52-61 vimentin Homo sapiens 20-28 16328963-6 2006 The vimentin level was found to decrease dramatically by the treatment of geldanamycin. geldanamycin 74-86 vimentin Homo sapiens 4-12 16328963-9 2006 The caspase inhibitors, Z-VAD-FMK and Ac-DEVD-CHO, completely abolished geldanamycin-induced cleavage of vimentin. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 24-33 vimentin Homo sapiens 105-113 16328963-9 2006 The caspase inhibitors, Z-VAD-FMK and Ac-DEVD-CHO, completely abolished geldanamycin-induced cleavage of vimentin. acetyl-aspartyl-glutamyl-valyl-aspartal 38-49 vimentin Homo sapiens 105-113 16328963-9 2006 The caspase inhibitors, Z-VAD-FMK and Ac-DEVD-CHO, completely abolished geldanamycin-induced cleavage of vimentin. geldanamycin 72-84 vimentin Homo sapiens 105-113 16328963-10 2006 Changes of HSP90 level by antisense treatment or transfection of HSP90-overexpressing vector affected geldanamycin-induced cleavage of vimentin. geldanamycin 102-114 vimentin Homo sapiens 135-143 16328963-11 2006 These results suggest that HSP90 protects vimentin by physical interaction in the geldanamycin-induced apoptotic pathway. geldanamycin 82-94 vimentin Homo sapiens 42-50 16140754-6 2005 Interestingly, viral DNA replication also resulted in the activation of calcium calmodulin-dependent protein kinase II (CaM kinase II) and phosphorylation of the N-terminal domain of vimentin on serine 82. Serine 195-201 vimentin Homo sapiens 183-191 16140754-7 2005 Immunostaining showed that vimentin within the cage was phosphorylated on serine 82. Serine 74-80 vimentin Homo sapiens 27-35 16140754-9 2005 Phosphorylation of vimentin on serine 82 may be necessary for cage formation or may simply be a consequence of activation of CaM kinase II by ASFV. Serine 31-37 vimentin Homo sapiens 19-27 15819415-6 2005 Furthermore, when vimentin and desmin tetramers were mixed in 5 mM Tris-HCl, pH 8.4, and subsequently subjected to IF assembly conditions, again "hybrid" filaments were obtained. Tris hydrochloride 67-75 vimentin Homo sapiens 18-26 16077980-0 2005 Transcriptional repression of vimentin gene expression by pyrroline dithiocarbamate during 12-O-tetradecanoylphorbol-13-acetate-dependent differentiation of HL-60 cells. pyrroline dithiocarbamate 58-83 vimentin Homo sapiens 30-38 16077980-0 2005 Transcriptional repression of vimentin gene expression by pyrroline dithiocarbamate during 12-O-tetradecanoylphorbol-13-acetate-dependent differentiation of HL-60 cells. Tetradecanoylphorbol Acetate 91-127 vimentin Homo sapiens 30-38 16077980-2 2005 To gain insight into the role of NF-kappaB in the regulation of the vimentin gene during 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent differentiation of HL-60 cells, the effect of pyrrolidine dithiocarbamete (PDTC) has been investigated using Northern blot hybridization and DNA mobility shift assay. Tetradecanoylphorbol Acetate 89-125 vimentin Homo sapiens 68-76 16077980-2 2005 To gain insight into the role of NF-kappaB in the regulation of the vimentin gene during 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent differentiation of HL-60 cells, the effect of pyrrolidine dithiocarbamete (PDTC) has been investigated using Northern blot hybridization and DNA mobility shift assay. Tetradecanoylphorbol Acetate 127-130 vimentin Homo sapiens 68-76 16077980-4 2005 TPA-dependent increase of vimentin mRNA level was decreased in a time- and dose-dependent manner by pretreatment with PDTC. Tetradecanoylphorbol Acetate 0-3 vimentin Homo sapiens 26-34 16077980-7 2005 Taken together, these results suggest that NF-kappaB may be an essential transacting factor for transcriptional repression of the vimentin gene by PDTC during TPA-dependent differentiation of HL-60 cells. Tetradecanoylphorbol Acetate 159-162 vimentin Homo sapiens 130-138 15766329-0 2005 Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine. Serine 73-76 vimentin Homo sapiens 45-53 15766329-0 2005 Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine. Serotonin 167-186 vimentin Homo sapiens 45-53 15766329-0 2005 Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine. Serotonin 167-186 vimentin Homo sapiens 105-113 15766329-3 2005 Vimentin filaments became straight and were arranged along the long axis of cells upon stimulation with 5-hydroxytryptamine (5-HT; serotonin). Serotonin 104-123 vimentin Homo sapiens 0-8 15766329-3 2005 Vimentin filaments became straight and were arranged along the long axis of cells upon stimulation with 5-hydroxytryptamine (5-HT; serotonin). Serotonin 131-140 vimentin Homo sapiens 0-8 15766329-4 2005 Stimulation of smooth muscle cells with 5-HT also induced phosphorylation of vimentin on Ser-56. Serine 89-92 vimentin Homo sapiens 77-85 15797859-8 2005 In addition, inactivation of Src, MKK3, p38, or the EGF receptor blocked tyrosine phosphorylation of beta-catenin, a key signaling intermediate that is involved in the epithelial-mesenchymal transition and vimentin expression. Tyrosine 73-81 vimentin Homo sapiens 206-214 15713670-0 2005 The intermediate filament protein vimentin is a new target for epigallocatechin gallate. epigallocatechin gallate 63-87 vimentin Homo sapiens 34-42 15713670-6 2005 Experiments using a pull-down assay with [3H]EGCG demonstrate binding of EGCG to vimentin with a Kd of 3.3 nm. Tritium 42-44 vimentin Homo sapiens 81-89 15713670-6 2005 Experiments using a pull-down assay with [3H]EGCG demonstrate binding of EGCG to vimentin with a Kd of 3.3 nm. epigallocatechin gallate 45-49 vimentin Homo sapiens 81-89 15713670-6 2005 Experiments using a pull-down assay with [3H]EGCG demonstrate binding of EGCG to vimentin with a Kd of 3.3 nm. epigallocatechin gallate 73-77 vimentin Homo sapiens 81-89 15713670-7 2005 EGCG inhibited phosphorylation of vimentin at serines 50 and 55 and phosphorylation of vimentin by cyclin-dependent kinase 2 and cAMP-dependent protein kinase. epigallocatechin gallate 0-4 vimentin Homo sapiens 34-42 15713670-7 2005 EGCG inhibited phosphorylation of vimentin at serines 50 and 55 and phosphorylation of vimentin by cyclin-dependent kinase 2 and cAMP-dependent protein kinase. epigallocatechin gallate 0-4 vimentin Homo sapiens 87-95 15713670-7 2005 EGCG inhibited phosphorylation of vimentin at serines 50 and 55 and phosphorylation of vimentin by cyclin-dependent kinase 2 and cAMP-dependent protein kinase. Serine 46-53 vimentin Homo sapiens 34-42 15713670-8 2005 EGCG specifically inhibits cell proliferation by binding to vimentin. epigallocatechin gallate 0-4 vimentin Homo sapiens 60-68 15713670-9 2005 Because vimentin is important for maintaining cellular functions and is essential in maintaining the structure and mechanical integration of the cellular space, the inhibitory effect of EGCG on vimentin may further explain its anti-tumor-promoting effect. epigallocatechin gallate 186-190 vimentin Homo sapiens 194-202 15824216-19 2005 Based on the overall evidence available on verteporfin therapy for these lesions, the VIM Study Group would consider recommending verteporfin therapy for relatively small minimally classic lesions similar to those enrolled in the VIM Trial. Verteporfin 130-141 vimentin Homo sapiens 86-89 15725803-9 2005 The stromal component of all phyllodes tumors was positive for vimentin, whereas all other investigated markers were absent except for focal p63 and CD10 expression in 1 case each. phyllodes 29-38 vimentin Homo sapiens 63-71 16158255-4 2005 Cholecalciferol, at physiological levels: (i) inhibited anchorage-dependent and -independent growth; (ii) induced differentiation by decreasing vimentin expression with a concomitant decrease in motility/chemotaxis; (iii) decreased MMP-9 and MMP-2 activity with concomitant decrease in invasion; and (iv) exerted its effects by up-regulating vitamin D receptor (VDR), retinoid-X receptor-alpha (RXR-alpha), and androgen receptor (AR) in a dose-dependent manner. Cholecalciferol 0-15 vimentin Homo sapiens 144-152 15682461-5 2005 The etoposide resistant clone showed overexpression of the following proteins: peroxiredoxin 1, beta-galactoside soluble lectin binding protein, vimentin (three protein spots), heat shock 27 kDa protein (two protein spots) and heterogeneous nuclear ribonucleoprotein K. In addition, we also found down-regulation of dUTP pyrophosphatase. Etoposide 4-13 vimentin Homo sapiens 145-153 15875079-0 2005 Estimation of taxol influence on changes in tubulin and vimentin systems in K-562 and HL-60 cell lines by immunofluorescence microscopy. Paclitaxel 14-19 vimentin Homo sapiens 56-64 15670151-0 2005 Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells. Methotrexate 86-98 vimentin Homo sapiens 52-60 15670151-7 2005 Inhibition of IMPDH or TOP1 activity, antisense treatment against survivin, or overexpression of vimentin, sensitized resistant HT29 cells to MTX. Methotrexate 142-145 vimentin Homo sapiens 97-105 15875079-2 2005 The study describes alterations in the distribution of vimentin and tubulin in taxol treated K-562 and HL-60 cells in relation to apoptotic changes. Paclitaxel 79-84 vimentin Homo sapiens 55-63 15254749-11 2004 PGJ2 increased expression of glial fibrillary acidic protein (GFAP) and decreased levels of vimentin, structural proteins modulated during astrocytic differentiation. 15-deoxy-delta(12,14)-prostaglandin J2 0-4 vimentin Homo sapiens 92-100 16424683-3 2005 This work addresses construction of the PFA for the ventrointermediate nucleus (PFA-VIM). pfa 40-43 vimentin Homo sapiens 84-87 16424683-4 2005 The PFA-VIM is constructed from pre-, intra- and postoperative electrophysiological and neuroimaging data acquired during the surgical treatment of Parkinson"s disease patients. pfa 4-7 vimentin Homo sapiens 8-11 16424683-7 2005 An algorithm was developed to convert these data into the PFA-VIM, and to present them on axial, coronal and sagittal planes and in 3-D. pfa 58-61 vimentin Homo sapiens 62-65 16424683-8 2005 The PFA-VIM gives a spatial distribution of the best contacts, and its probability is proportional to best contact concentration in a given location. pfa 4-7 vimentin Homo sapiens 8-11 16424683-10 2005 The PFA-VIM is calculated with 0.25-mm3 resolution from 107 best contacts in two situations: with and without lateral compensation against the width of the third ventricle. pfa 4-7 vimentin Homo sapiens 8-11 16424683-11 2005 For the PFA-VIM compensated laterally, the anterior, lateral and dorsal coordinates of the mean value are (in mm) 6.24, 13.83, 1.68 for the left VIM and 6.54, -13.84, 2.10 for the right VIM. pfa 8-11 vimentin Homo sapiens 12-15 16424683-11 2005 For the PFA-VIM compensated laterally, the anterior, lateral and dorsal coordinates of the mean value are (in mm) 6.24, 13.83, 1.68 for the left VIM and 6.54, -13.84, 2.10 for the right VIM. pfa 8-11 vimentin Homo sapiens 145-148 16424683-11 2005 For the PFA-VIM compensated laterally, the anterior, lateral and dorsal coordinates of the mean value are (in mm) 6.24, 13.83, 1.68 for the left VIM and 6.54, -13.84, 2.10 for the right VIM. pfa 8-11 vimentin Homo sapiens 145-148 16424683-14 2005 For the PFA-VIM not compensated laterally, the coordinates of the mean value are 6.24, 13.99, 1.68 for the left VIM and 6.53, -14.13, 2.10 for the right VIM. pfa 8-11 vimentin Homo sapiens 12-15 16424683-14 2005 For the PFA-VIM not compensated laterally, the coordinates of the mean value are 6.24, 13.99, 1.68 for the left VIM and 6.53, -14.13, 2.10 for the right VIM. pfa 8-11 vimentin Homo sapiens 112-115 16424683-14 2005 For the PFA-VIM not compensated laterally, the coordinates of the mean value are 6.24, 13.99, 1.68 for the left VIM and 6.53, -14.13, 2.10 for the right VIM. pfa 8-11 vimentin Homo sapiens 112-115 15389604-6 2004 Administration of kainic acid induced the expression of vimentin in reactive astroglia and a significant neuronal loss in the hilus. Kainic Acid 18-29 vimentin Homo sapiens 56-64 15389604-7 2004 SERMs did not affect vimentin immunoreactivity in the hilus, while 17beta-estradiol significantly reduced the surface density of vimentin immunoreactive profiles. Estradiol 74-83 vimentin Homo sapiens 129-137 15494938-8 2004 The proliferating histiocytes had ultrastructural findings of paclitaxel-induced cytotoxicity with disorganized stacks of intermediate filaments positive for vimentin by immunostains and fewer masses of tubulin. Paclitaxel 62-72 vimentin Homo sapiens 158-166 15456890-4 2004 In the present study we have used protein purification and tandem mass spectrometry analysis of tryptic peptides to identify the PAL-E antigen as a secreted form of vimentin. Peptides 104-112 vimentin Homo sapiens 165-173 15468128-4 2004 These RRTCs stained strongly positively with vimentin antibody in 92.3% of the cases. rrtcs 6-11 vimentin Homo sapiens 45-53 15231822-8 2004 A continuation of this strategy revealed that both 191-191 and 348-348 interactions are present in low ionic strength Tris buffers when vimentin is maintained at the "protofilament" stage of assembly. Tromethamine 118-122 vimentin Homo sapiens 136-144 15378611-5 2004 Interestingly, 3.6% of total AMCs expressed the phenotype CK19+/vimentin+, indicating coexpression of epithelial and mesenchyme cell markers. amcs 29-33 vimentin Homo sapiens 64-72 15738865-9 2004 Vimentin is rather specific of CCC (54.5%) and CTP (85%) whereas it is negative in ONCO and CCHRO. Cytidine Triphosphate 47-50 vimentin Homo sapiens 0-8 15274135-10 2004 Moreover, upon activation the bulk of vimentin behaved as a dimer (M(r) 120 kDa) being slightly tyrosylated, yet phosphorylated at Thr-425 possibly as a requirement for its externalization. Threonine 131-134 vimentin Homo sapiens 38-46 15184025-1 2004 We have developed an assembly protocol for the intermediate filament (IF) protein vimentin based on a phosphate buffer system, which enables the dynamic formation of authentic IFs. Phosphates 102-111 vimentin Homo sapiens 82-90 15140879-7 2004 Furthermore, overexpression of PPM1F in fibroblasts caused a reduction in the CaMKII-specific phosphorylation of the known substrate vimentin(Ser-82) following induction of the endogenous CaM kinase. Serine 142-145 vimentin Homo sapiens 133-141 15272307-1 2004 Mammalian formiminotransferase cyclodeaminase (FTCD), a 0.5 million Dalton homo-octameric enzyme, plays important roles in coupling histidine catabolism with folate metabolism and integrating the Golgi complex with the vimentin intermediate filament cytoskeleton. Histidine 132-141 vimentin Homo sapiens 219-227 15272307-1 2004 Mammalian formiminotransferase cyclodeaminase (FTCD), a 0.5 million Dalton homo-octameric enzyme, plays important roles in coupling histidine catabolism with folate metabolism and integrating the Golgi complex with the vimentin intermediate filament cytoskeleton. Folic Acid 158-164 vimentin Homo sapiens 219-227 15184025-4 2004 We show that headless vimentin, which dimerizes under low salt conditions, associates into tetramers of the A(22)-type configuration under assembly conditions, indicating that one of the effects of increasing the ionic strength is to favor coil 2-coil 2 interactions. Salts 58-62 vimentin Homo sapiens 22-30 15061884-9 2004 The oral CAFs showed negative staining for cytokeratin, and positive staining for vimentin, alpha-smooth muscle actin and matrix metalloproteinases-2. cafs 9-13 vimentin Homo sapiens 82-90 15341079-5 2004 When vimentin filaments were induced to collapse by demecolcine, intermediate filaments and WPBs both translocated to the perinuclear region. Demecolcine 52-63 vimentin Homo sapiens 5-13 14752105-8 2004 The activated TGase 2 catalyzed the formation of water-insoluble dimers or polymers of alphaB-crystallin, betaB(2)-crystallin, and vimentin in HLE-B3 cells, providing evidence that TGase 2 may play a role in cataractogenesis. Water 49-54 vimentin Homo sapiens 131-139 15043254-1 2004 A new synthesized copolymer based on N-vinylimidazole-divinylbenzene (VIm-DVB) was tested as a sorbent for the solid-phase extraction (SPE) of polar analytes. copolymer 18-27 vimentin Homo sapiens 70-73 15043254-1 2004 A new synthesized copolymer based on N-vinylimidazole-divinylbenzene (VIm-DVB) was tested as a sorbent for the solid-phase extraction (SPE) of polar analytes. n-vinylimidazole-divinylbenzene 37-68 vimentin Homo sapiens 70-73 15087219-5 2004 Most batches of TC from first trimester or term placentae (92+/-3% and 96+/-2%, respectively) showed a high percentage of CK7 expressing cells, with less than 2% contaminating vimentin positive cells. Technetium 16-18 vimentin Homo sapiens 176-184 15114646-5 2004 Immunohistochemistry with a mesenchymal cell marker, vimentin, revealed a highly significant reduction of vimentin staining in the mesenchyme of CAPE-treated regenerates (p<0.001). caffeic acid phenethyl ester 145-149 vimentin Homo sapiens 53-61 15114646-5 2004 Immunohistochemistry with a mesenchymal cell marker, vimentin, revealed a highly significant reduction of vimentin staining in the mesenchyme of CAPE-treated regenerates (p<0.001). caffeic acid phenethyl ester 145-149 vimentin Homo sapiens 106-114 15072103-0 2004 Radial and tangential neuronal migration disorder in ibotenate-induced cortical lesions in hamsters: immunohistochemical study of reelin, vimentin, and calretinin. Ibotenic Acid 53-62 vimentin Homo sapiens 138-146 15177097-1 2004 Poly(ethylene glycol dimethacrylate-n-vinyl imidazole) [poly(EGDMA-VIM)] hydrogel (average diameter 150-200 microm) was prepared by copolymerizing ethylene glycol dimethacrylate (EGDMA) with n-vinyl imidazole (VIM). poly(ethylene glycol dimethacrylate-n-vinyl imidazole) 0-54 vimentin Homo sapiens 67-70 15177097-1 2004 Poly(ethylene glycol dimethacrylate-n-vinyl imidazole) [poly(EGDMA-VIM)] hydrogel (average diameter 150-200 microm) was prepared by copolymerizing ethylene glycol dimethacrylate (EGDMA) with n-vinyl imidazole (VIM). poly(ethylene glycol dimethacrylate-n-vinyl imidazole) 0-54 vimentin Homo sapiens 210-213 15177097-1 2004 Poly(ethylene glycol dimethacrylate-n-vinyl imidazole) [poly(EGDMA-VIM)] hydrogel (average diameter 150-200 microm) was prepared by copolymerizing ethylene glycol dimethacrylate (EGDMA) with n-vinyl imidazole (VIM). ethylene dimethacrylate 5-35 vimentin Homo sapiens 67-70 15177097-1 2004 Poly(ethylene glycol dimethacrylate-n-vinyl imidazole) [poly(EGDMA-VIM)] hydrogel (average diameter 150-200 microm) was prepared by copolymerizing ethylene glycol dimethacrylate (EGDMA) with n-vinyl imidazole (VIM). ethylene dimethacrylate 61-66 vimentin Homo sapiens 67-70 15177097-1 2004 Poly(ethylene glycol dimethacrylate-n-vinyl imidazole) [poly(EGDMA-VIM)] hydrogel (average diameter 150-200 microm) was prepared by copolymerizing ethylene glycol dimethacrylate (EGDMA) with n-vinyl imidazole (VIM). N-vinylimidazole 36-53 vimentin Homo sapiens 67-70 15177097-1 2004 Poly(ethylene glycol dimethacrylate-n-vinyl imidazole) [poly(EGDMA-VIM)] hydrogel (average diameter 150-200 microm) was prepared by copolymerizing ethylene glycol dimethacrylate (EGDMA) with n-vinyl imidazole (VIM). N-vinylimidazole 36-53 vimentin Homo sapiens 210-213 15177097-2 2004 The copolymer hydrogel bead composition was characterized by elemental analysis and found to contain 5 EGDMA monomer units each VIM monomer unit. copolymer 4-13 vimentin Homo sapiens 128-131 15177097-3 2004 Poly(EGDMA-VIM) beads had a specific surface area of 59.8 m2/g. poly 0-4 vimentin Homo sapiens 11-14 15177097-5 2004 These poly(EGDMA-VIM) beads with a swelling ratio of 78% were used for the heavy metal removal studies. Metals 81-86 vimentin Homo sapiens 17-20 15177097-8 2004 The maximum chelation capacities of the poly(EGDMA-VIM) beads were 69.4 mg/g for Cd(II), 114.8 mg/g for Pb(II) and 163.5 mg/g for Hg(II). poly 40-44 vimentin Homo sapiens 51-54 15177097-8 2004 The maximum chelation capacities of the poly(EGDMA-VIM) beads were 69.4 mg/g for Cd(II), 114.8 mg/g for Pb(II) and 163.5 mg/g for Hg(II). cd(ii) 81-87 vimentin Homo sapiens 51-54 15177097-15 2004 These features make poly(EGDMA-VIM) beads potential candidate adsorbent for heavy metal removal. Metals 82-87 vimentin Homo sapiens 31-34 14670623-0 2004 Differential regulation of vimentin mRNA by 12-O-tetradecanoylphorbol 13-acetate and all-trans-retinoic acid correlates with motility of Hep 3B human hepatocellular carcinoma cells. Tetradecanoylphorbol Acetate 44-80 vimentin Homo sapiens 27-35 14670623-0 2004 Differential regulation of vimentin mRNA by 12-O-tetradecanoylphorbol 13-acetate and all-trans-retinoic acid correlates with motility of Hep 3B human hepatocellular carcinoma cells. Tretinoin 85-108 vimentin Homo sapiens 27-35 14670623-3 2004 We studied the regulation of vimentin mRNA and multistep invasion processes following treatment of 12-O-tetradecanoylphorbol 13-acetate (TPA) and all-trans-retinoic acid (RA) in Hep 3B hepatocellular carcinoma cells. Tetradecanoylphorbol Acetate 99-135 vimentin Homo sapiens 29-37 14670623-3 2004 We studied the regulation of vimentin mRNA and multistep invasion processes following treatment of 12-O-tetradecanoylphorbol 13-acetate (TPA) and all-trans-retinoic acid (RA) in Hep 3B hepatocellular carcinoma cells. Tetradecanoylphorbol Acetate 137-140 vimentin Homo sapiens 29-37 14670623-3 2004 We studied the regulation of vimentin mRNA and multistep invasion processes following treatment of 12-O-tetradecanoylphorbol 13-acetate (TPA) and all-trans-retinoic acid (RA) in Hep 3B hepatocellular carcinoma cells. Tretinoin 146-169 vimentin Homo sapiens 29-37 14670623-3 2004 We studied the regulation of vimentin mRNA and multistep invasion processes following treatment of 12-O-tetradecanoylphorbol 13-acetate (TPA) and all-trans-retinoic acid (RA) in Hep 3B hepatocellular carcinoma cells. Tretinoin 171-173 vimentin Homo sapiens 29-37 14670623-4 2004 TPA showed marked induction of vimentin mRNA, while RA decreased the mRNA level. Tetradecanoylphorbol Acetate 0-3 vimentin Homo sapiens 31-39 14670623-7 2004 These findings suggest that TPA and RA could modulate the invasive potential of Hep 3B cells by altering cellular motility related to differential regulation of vimentin mRNA. Tetradecanoylphorbol Acetate 28-31 vimentin Homo sapiens 161-169 14670623-7 2004 These findings suggest that TPA and RA could modulate the invasive potential of Hep 3B cells by altering cellular motility related to differential regulation of vimentin mRNA. Tretinoin 36-38 vimentin Homo sapiens 161-169 15059270-3 2004 It has recently been confirmed that anti-Sa antibodies are directed to citrullinated vimentin, thus placing them in the anti-citrulline family of autoantibodies. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 41-43 vimentin Homo sapiens 85-93 15059270-3 2004 It has recently been confirmed that anti-Sa antibodies are directed to citrullinated vimentin, thus placing them in the anti-citrulline family of autoantibodies. Citrulline 125-135 vimentin Homo sapiens 85-93 15059278-8 2004 Since antibodies to citrullinated proteins are known to be highly specific for RA, we investigated whether Sa is citrullinated and found that Sa indeed is citrullinated vimentin. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 107-109 vimentin Homo sapiens 169-177 15059278-8 2004 Since antibodies to citrullinated proteins are known to be highly specific for RA, we investigated whether Sa is citrullinated and found that Sa indeed is citrullinated vimentin. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 142-144 vimentin Homo sapiens 169-177 14648556-6 2004 The expression of green fluorescent protein-tagged cytokeratin18 arg89cys induced aggregations and loss of the intermediate filament network composed of cytokeratins in liver-derived epithelial cells, Huh7 and OUMS29, but only induced the formation of cytokeratin aggregates and did not affect the intermediate filament network of endogenous vimentin in HEK293. arg89cys 65-73 vimentin Homo sapiens 342-350 15229395-3 2004 Noteworthy, the correct course of ganglioside/glycosphingolipid metabolism requires the presence of the vimentin intracellular filament net work, likely to assist intracellular transport of sphingoid molecules. Gangliosides 34-45 vimentin Homo sapiens 104-112 15229395-3 2004 Noteworthy, the correct course of ganglioside/glycosphingolipid metabolism requires the presence of the vimentin intracellular filament net work, likely to assist intracellular transport of sphingoid molecules. Glycosphingolipids 46-63 vimentin Homo sapiens 104-112 15229395-3 2004 Noteworthy, the correct course of ganglioside/glycosphingolipid metabolism requires the presence of the vimentin intracellular filament net work, likely to assist intracellular transport of sphingoid molecules. Sphingosine 190-199 vimentin Homo sapiens 104-112 14531910-2 2003 We studied patients with recurrent or persistent aggressive non-Hodgkin"s lymphoma (NHL) and Hodgkin"s disease (HD), who were treated with three courses of second-line induction chemotherapy [DHAP-VIM (dexamethasone, cytarabine, cisplatin followed by etoposide, iphosphamide and methotrexate)-DHAP], followed by myeloablative therapy and ASCT if chemosensitive. Dexamethasone 202-215 vimentin Homo sapiens 197-200 14644170-4 2003 The 7-ketocholesterol induced cell arborisation, with bundling of vimentin and tubulin in the cell processes and formation of filopodia and stress fibres. 7-ketocholesterol 4-21 vimentin Homo sapiens 66-74 14644170-5 2003 Cells treated with 25-hydroxycholesterol showed a collapse of vimentin filaments towards the nucleus and formation of lamellipodia. 25-hydroxycholesterol 19-40 vimentin Homo sapiens 62-70 14992324-4 2003 However, MeHgCl prevents the degradation of vimentin differently than GM-CSF. methylmercuric chloride 9-15 vimentin Homo sapiens 44-52 14992324-8 2003 However, unlike GM-CSF, MeHgCl induces an atypical degradation of vimentin without preventing CD16 shedding. methylmercuric chloride 24-30 vimentin Homo sapiens 66-74 12829607-5 2003 Vimentin is partially exposed on the surface of apoptotic T cells and binds hGIIA via its rod domain in a calcium-independent manner. Calcium 106-113 vimentin Homo sapiens 0-8 14555241-5 2003 Etoposide- and doxorubicin-treated cells showed similar changes in the distribution of F-actin, vimentin and tubulin. Etoposide 0-9 vimentin Homo sapiens 96-104 14762106-3 2004 Inhibition of type-1 (PP1) and type-2A (PP2A) protein phosphatases in BHK-21 fibroblasts with calyculin-A, induced rapid vimentin phosphorylation in concert with disassembly of the IF polymers into soluble tetrameric vimentin oligomers. calyculin A 94-105 vimentin Homo sapiens 121-129 14762106-3 2004 Inhibition of type-1 (PP1) and type-2A (PP2A) protein phosphatases in BHK-21 fibroblasts with calyculin-A, induced rapid vimentin phosphorylation in concert with disassembly of the IF polymers into soluble tetrameric vimentin oligomers. calyculin A 94-105 vimentin Homo sapiens 217-225 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Serine 77-80 vimentin Homo sapiens 38-46 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Serine 84-87 vimentin Homo sapiens 38-46 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Serine 84-87 vimentin Homo sapiens 38-46 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Serine 84-87 vimentin Homo sapiens 38-46 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Serine 84-87 vimentin Homo sapiens 38-46 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Serine 84-87 vimentin Homo sapiens 38-46 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Serine 84-87 vimentin Homo sapiens 38-46 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Serine 84-87 vimentin Homo sapiens 38-46 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Serine 84-87 vimentin Homo sapiens 38-46 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Serine 84-87 vimentin Homo sapiens 38-46 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Serine 84-87 vimentin Homo sapiens 38-46 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Threonine 162-165 vimentin Homo sapiens 38-46 14762106-5 2004 Characterization of the (32)P-labeled vimentin phosphopeptides, demonstrated Ser-4, Ser-6, Ser-7, Ser-8, Ser-9, Ser-38, Ser-41, Ser-71, Ser-72, Ser-418, Ser-429, Thr-456, and Ser-457 as significant in vivo phosphorylation sites. Serine 84-87 vimentin Homo sapiens 38-46 14644170-9 2003 Similarly, the collapse of vimentin intermediate filament network and the formation of lamellipodia, induced by 25-hydroxycholesterol, is inhibited by overexpressing dominant negatives forms of Rac1. 25-hydroxycholesterol 112-133 vimentin Homo sapiens 27-35 14654785-0 2003 c-Jun and the dominant-negative mutant, TAM67, induce vimentin gene expression by interacting with the activator Sp1. tam67 40-45 vimentin Homo sapiens 54-62 14654785-6 2003 Previously, tandem AP1 sites in the promoter were reported to be important for the serum and TPA inducibility of the vimentin gene. Tetradecanoylphorbol Acetate 93-96 vimentin Homo sapiens 117-125 14555241-5 2003 Etoposide- and doxorubicin-treated cells showed similar changes in the distribution of F-actin, vimentin and tubulin. Doxorubicin 15-26 vimentin Homo sapiens 96-104 14531910-2 2003 We studied patients with recurrent or persistent aggressive non-Hodgkin"s lymphoma (NHL) and Hodgkin"s disease (HD), who were treated with three courses of second-line induction chemotherapy [DHAP-VIM (dexamethasone, cytarabine, cisplatin followed by etoposide, iphosphamide and methotrexate)-DHAP], followed by myeloablative therapy and ASCT if chemosensitive. Dihydroxyacetone Phosphate 192-196 vimentin Homo sapiens 197-200 12711954-5 2003 After 2 weeks of treatment of PLA cells with isobutylmethylxanthine, indomethacin, and insulin, about 20 to 25 percent of the cells differentiated into cells with typical neural morphologic characteristics, accompanied by increased expression of NSE, vimentin, and the nerve-growth factor receptor trk-A. 1-Methyl-3-isobutylxanthine 45-67 vimentin Homo sapiens 251-259 12759236-7 2003 Expression of keratin and vimentin but not beta-catenin was up-regulated in progesterone treated cells when evaluated by immunoblotting. Progesterone 76-88 vimentin Homo sapiens 26-34 12761892-7 2003 We show that MAPKAP kinase-2 mainly phosphorylates vimentin at Ser-38, Ser-50, Ser-55, and Ser-82, residues all located in the head domain of the protein. Serine 63-66 vimentin Homo sapiens 51-59 12761892-7 2003 We show that MAPKAP kinase-2 mainly phosphorylates vimentin at Ser-38, Ser-50, Ser-55, and Ser-82, residues all located in the head domain of the protein. Serine 71-74 vimentin Homo sapiens 51-59 12761892-7 2003 We show that MAPKAP kinase-2 mainly phosphorylates vimentin at Ser-38, Ser-50, Ser-55, and Ser-82, residues all located in the head domain of the protein. Serine 71-74 vimentin Homo sapiens 51-59 12761892-7 2003 We show that MAPKAP kinase-2 mainly phosphorylates vimentin at Ser-38, Ser-50, Ser-55, and Ser-82, residues all located in the head domain of the protein. Serine 71-74 vimentin Homo sapiens 51-59 12761892-10 2003 Finally, a mutational analysis of each of the phosphorylated serine residues in vimentin suggested that no single serine site was primarily responsible for structure maintenance, implying that the retention of filamentous structure may be the result of the coordinated action of several phosphorylated serine sites. Serine 61-67 vimentin Homo sapiens 80-88 12761892-10 2003 Finally, a mutational analysis of each of the phosphorylated serine residues in vimentin suggested that no single serine site was primarily responsible for structure maintenance, implying that the retention of filamentous structure may be the result of the coordinated action of several phosphorylated serine sites. Serine 114-120 vimentin Homo sapiens 80-88 12761892-10 2003 Finally, a mutational analysis of each of the phosphorylated serine residues in vimentin suggested that no single serine site was primarily responsible for structure maintenance, implying that the retention of filamentous structure may be the result of the coordinated action of several phosphorylated serine sites. Serine 114-120 vimentin Homo sapiens 80-88 12761892-11 2003 This also shed new lights on the functional task(s) of vimentin that is intermediate filament proteins might provide a phosphate reservoir to accommodate the phosphate surge without any structural changes. Phosphates 119-128 vimentin Homo sapiens 55-63 12761892-11 2003 This also shed new lights on the functional task(s) of vimentin that is intermediate filament proteins might provide a phosphate reservoir to accommodate the phosphate surge without any structural changes. Phosphates 158-167 vimentin Homo sapiens 55-63 14533848-2 2003 We compared the effects of two AR procedures, enzyme digestion and microwave heating, on immunostaining of vimentin and desmin in formalin fixed, paraffin embedded tissues. Formaldehyde 130-138 vimentin Homo sapiens 107-115 12823903-1 2003 The isolation from proliferating mouse and human embryo fibroblasts of SDS-stable crosslinkage products of vimentin with DNA fragments containing inverted repeats capable of cruciform formation under superhelical stress and the competitive effect of a synthetic Holliday junction on the binding of cytoplasmic intermediate filament (cIF) proteins to supercoiled DNA prompted a detailed investigation of the proteins" capacity to associate with four-way junction DNA and to influence its processing by junction-resolving endonucleases. Sodium Dodecyl Sulfate 71-74 vimentin Homo sapiens 107-115 12823903-7 2003 This effect is very likely due to vimentin-induced structural distortion of the branchpoint, as suggested by the results of hydroxyl radical footprinting of Holliday junctions in the absence and the presence of vimentin. Hydroxyl Radical 124-140 vimentin Homo sapiens 34-42 12691412-3 2003 METHODS: Cultured human glioma cells were immunostained with monoclonal antibodies (mAbs) 4A4, KT13, and TM71, which recognized the phosphorylation of vimentin at Ser55, glial fibrillary acidic protein at Serl3, and vimentin at Ser71, respectively. serl3 205-210 vimentin Homo sapiens 151-159 12686602-4 2003 This nestin-mediated disassembly of IFs is dependent on the phosphorylation of vimentin by the maturation/M-phase-promoting factor at ser-55 in the amino-terminal head domain. Serine 134-137 vimentin Homo sapiens 79-87 12458200-2 2003 We previously demonstrated the possible existence of a protein kinase that phosphorylates at least Ser-72 on vimentin, the most widely expressed intermediate filament protein, in the cleavage furrow-specific manner. Serine 99-102 vimentin Homo sapiens 109-117 12458200-3 2003 Here we showed that vimentin-Ser-72 phosphorylation occurred specifically at the border of the Aurora-B-localized area from anaphase to telophase. Serine 29-32 vimentin Homo sapiens 20-28 12458200-4 2003 Expression of a dominant-negative mutant of Aurora-B led to a reduction of this vimentin-Ser-72 phosphorylation. Serine 89-92 vimentin Homo sapiens 80-88 12458200-5 2003 In vitro analyses revealed that Aurora-B phosphorylates vimentin at approximately 2 mol phosphate/mol of substrate for 30 min and that this phosphorylation dramatically inhibits vimentin filament formation. Phosphates 88-97 vimentin Homo sapiens 56-64 12458200-6 2003 We further identified eight Aurora-B phosphorylation sites, including Ser-72 on vimentin, and then constructed the mutant vimentin in which these identified sites are changed into Ala. Serine 70-73 vimentin Homo sapiens 80-88 12458200-6 2003 We further identified eight Aurora-B phosphorylation sites, including Ser-72 on vimentin, and then constructed the mutant vimentin in which these identified sites are changed into Ala. Alanine 180-183 vimentin Homo sapiens 122-130 12553669-8 2002 We report that p70 S6 kinase (S6K)1 participates in this IF rearrangement since the inhibitor rapamycin or a dominant inhibitory S6K could reduce the Cdc42V12 or bradykinin-induced vimentin collapse. Sirolimus 94-103 vimentin Homo sapiens 181-189 14753451-5 2003 The endothelial H2O2-stimulated Ca2+ mobilization and cytoskeleton (vimentin) rearrangement was modified by either 2-AG or TPL. Hydrogen Peroxide 16-20 vimentin Homo sapiens 68-76 14753451-5 2003 The endothelial H2O2-stimulated Ca2+ mobilization and cytoskeleton (vimentin) rearrangement was modified by either 2-AG or TPL. glyceryl 2-arachidonate 115-119 vimentin Homo sapiens 68-76 14753451-5 2003 The endothelial H2O2-stimulated Ca2+ mobilization and cytoskeleton (vimentin) rearrangement was modified by either 2-AG or TPL. tempol 123-126 vimentin Homo sapiens 68-76 12483219-4 2003 We show that secretion of vimentin, which is phosphorylated at serine and threonine residues, is enhanced by the phosphatase inhibitor okadaic acid and blocked by the specific protein kinase C inhibitor GO6983. Serine 63-69 vimentin Homo sapiens 26-34 12483219-4 2003 We show that secretion of vimentin, which is phosphorylated at serine and threonine residues, is enhanced by the phosphatase inhibitor okadaic acid and blocked by the specific protein kinase C inhibitor GO6983. Threonine 74-83 vimentin Homo sapiens 26-34 12483219-4 2003 We show that secretion of vimentin, which is phosphorylated at serine and threonine residues, is enhanced by the phosphatase inhibitor okadaic acid and blocked by the specific protein kinase C inhibitor GO6983. Okadaic Acid 135-147 vimentin Homo sapiens 26-34 12483219-4 2003 We show that secretion of vimentin, which is phosphorylated at serine and threonine residues, is enhanced by the phosphatase inhibitor okadaic acid and blocked by the specific protein kinase C inhibitor GO6983. 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide 203-209 vimentin Homo sapiens 26-34 12211104-6 2002 Vimentin filaments formed large bundles surrounding the nucleus in mtDNA-less (rho(0)) osteosarcoma cells and in osteosarcoma cells after incubation with sodium azide and nocodazole. Sodium Azide 154-166 vimentin Homo sapiens 0-8 12211104-6 2002 Vimentin filaments formed large bundles surrounding the nucleus in mtDNA-less (rho(0)) osteosarcoma cells and in osteosarcoma cells after incubation with sodium azide and nocodazole. Nocodazole 171-181 vimentin Homo sapiens 0-8 12110335-0 2002 Elevated vimentin expression in buccal mucosal fibroblasts by arecoline in vitro as a possible pathogenesis for oral submucous fibrosis. Arecoline 62-71 vimentin Homo sapiens 9-17 14745205-2 2003 We report the incidence of hemorrhage in a large series of DBS implants into the subthalamic nucleus (STN), thalamus (VIM) and internal globus pallidus (GPi). dbs 59-62 vimentin Homo sapiens 118-121 12133234-5 2002 It was also found that the cytoskeletal proteins gelsolin, paxillin, and vimentin, but not vinculin, were degraded by TBT via caspases, as assessed by immunoblotting. tributyltin 118-121 vimentin Homo sapiens 73-81 12133234-6 2002 Data indicate that gelsolin, paxillin, and vimentin are three caspase substrates involved in both spontaneous and TBT-induced neutrophil apoptosis. tributyltin 114-117 vimentin Homo sapiens 43-51 12139946-6 2002 In addition, toxaphene was found to induce the degradation of the cytoskeletal proteins gelsolin, paxillin, and vimentin during apoptosis, and this was reversed by the addition of z-VAD-FMK (caspase inhibitor) or catalase, demonstrating the importance of caspases and ROS in this process. Toxaphene 13-22 vimentin Homo sapiens 112-120 12110335-4 2002 In this study, in addition to conducting a cytotoxicity assay, we examine the effect of arecoline on vimentin, an intermediate filament, and its expression in human buccal mucosal fibroblasts on exposure to various levels of arecoline (0-200 microg/ml) for 48 h. At a concentration above 50 microg/ml, arecoline demonstrated dose-dependent cytotoxicity (P<0.05) for cultured fibroblasts. Arecoline 88-97 vimentin Homo sapiens 101-109 12110335-7 2002 The increase in vimentin with arecoline exposure corresponded to that noted for fibroblasts cultured from OSF patients. Arecoline 30-39 vimentin Homo sapiens 16-24 12003790-0 2002 Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin. Histamine 0-9 vimentin Homo sapiens 92-100 12003790-6 2002 At the same time, histamine decreased the amount of vimentin that immunoprecipitated with VE-cadherin by 50 +/- 6%. Histamine 18-27 vimentin Homo sapiens 52-60 11748579-14 2001 The two vimentin negative neoplasms, RO and CRCC, could be distinguished by HCI stain, which showed diffuse or focal cytoplasmic positivity in CRCCs and apical/perinuclear staining (73%) or negative staining (27%) in ROs. 3-phenylpropionic acid 76-79 vimentin Homo sapiens 8-16 11802775-11 2002 Cells overexpressing ORP4-S had a 40% reduction in the esterification of low-density-lipoprotein-derived cholesterol, demonstrating that ORP4 interaction with intermediate filaments inhibits an intracellular cholesterol-transport pathway mediated by vimentin. Cholesterol 105-116 vimentin Homo sapiens 250-258 11802775-11 2002 Cells overexpressing ORP4-S had a 40% reduction in the esterification of low-density-lipoprotein-derived cholesterol, demonstrating that ORP4 interaction with intermediate filaments inhibits an intracellular cholesterol-transport pathway mediated by vimentin. Cholesterol 208-219 vimentin Homo sapiens 250-258 12149570-6 2002 BFA (1 microg/ml medium) effectively blocked the transport of the glycoproteins to the plasma membranes and affected the tubulin and vimentin of the cytoskeleton. Brefeldin A 0-3 vimentin Homo sapiens 133-141 12149570-8 2002 Withdrawal of BFA influence up to 9 hr resulted in restored tubulin and vimentin, transport of glycoproteins to the plasma membranes, and steady release of infectious viral particles to the extracellular space superior to the cellular assembly of new virions. Brefeldin A 14-17 vimentin Homo sapiens 72-80 11748579-16 2001 CONCLUSIONS: This study demonstrated that ROs can be distinguished reliably from RCCs on the basis of cytologic morphology combined with ancillary studies, including immunostaining with cytokeratin and vimentin antibodies and HCI stain. ros 42-45 vimentin Homo sapiens 202-210 11798967-0 2001 [Treatment of dyskinetic disorders with tremor by lesioning and DBS of Vim]. dbs 64-67 vimentin Homo sapiens 71-74 11834357-3 2002 The results demonstrate that patients taking MMF instead of azathioprine generated significantly fewer de novo anti-vimentin antibodies. Mycophenolic Acid 45-48 vimentin Homo sapiens 116-124 11834357-3 2002 The results demonstrate that patients taking MMF instead of azathioprine generated significantly fewer de novo anti-vimentin antibodies. Azathioprine 60-72 vimentin Homo sapiens 116-124 11787820-1 2001 Standard immunohistochemical methods were used to detect the presence of vimentin, cytokeratin 8, cytokeratin 18, macrophages and Langerhans cells in the human tonsillar epithelium in formalin-fixed and frozen tissue specimens. Formaldehyde 184-192 vimentin Homo sapiens 73-81 11550207-4 2001 Treatment of cells with DOX downregulated PSA, E-cadherin, and keratin, and upregulated expression of vimentin and vascular endothelial growth factor (VEGF) mRNA. Doxorubicin 24-27 vimentin Homo sapiens 102-110 11911279-0 2001 Remodeling of vimentin cytoskeleton correlates with enhanced motility of promyelocytic leukemia cells during differentiation induced by retinoic acid. Tretinoin 136-149 vimentin Homo sapiens 14-22 11911279-5 2001 We demonstrated a down-regulation of vimentin after ATRA treatment of NB4 cells by immunoblotting and immunofluorescence. Tretinoin 52-56 vimentin Homo sapiens 37-45 11911279-7 2001 In contrast, we showed a slight increase of vimentin content in phorbol ester (PMA)-treated NB4 cells. Phorbol Esters 64-77 vimentin Homo sapiens 44-52 11911279-7 2001 In contrast, we showed a slight increase of vimentin content in phorbol ester (PMA)-treated NB4 cells. Tetradecanoylphorbol Acetate 79-82 vimentin Homo sapiens 44-52 11911279-8 2001 The structural features of the vimentin cytoskeleton obtained by image analysis showed significant differences in network density and directionality between ATRA-treated NB4 cells and controls. Tretinoin 157-161 vimentin Homo sapiens 31-39 11771868-11 2001 S-creatinine at biopsy was highest when tubular vimentin staining was strongest, and tubular vimentin staining was strongest in patients with acute tubular damage. Creatinine 2-12 vimentin Homo sapiens 48-56 11770401-7 2001 Vimentin was identified in the superficial layers of normal and immature cataractous lenses by SDS-PAGE and Western blot. Sodium Dodecyl Sulfate 95-98 vimentin Homo sapiens 0-8 11478838-3 2001 Immunoblotting analyses and capillary zone electrophoresis demonstrated that following RA treatment: lamins A/C and B1, and vimentin decreased to negligible amounts; LAP2 beta, lamin B2 and emerin remained essentially unchanged; lamin B receptor (LBR) increased markedly; histone subtypes H1.4 and 1.5 exhibited dephosphorylation. Tretinoin 87-89 vimentin Homo sapiens 124-132 11478838-4 2001 Following TPA treatment: lamins A/C and B1, B2 and vimentin increased in amount; LAP2 beta and emerin remained essentially unchanged; LBR increased markedly; histone subtypes H1.4 and 1.5 exhibited dephosphorylation. Tetradecanoylphorbol Acetate 10-13 vimentin Homo sapiens 51-59 11368515-0 2001 Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells. silicon phthalocyanine 84-106 vimentin Homo sapiens 18-26 11368515-6 2001 In the presence of benzyloxycarbonyl-Val-Ala-Asp(O-methyl)-fluoromethylketone, a pan-caspase inhibitor, Pc 4-PDT-induced vimentin and PARP cleavage were abolished. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 19-77 vimentin Homo sapiens 121-129 11431714-13 2001 The immunohistochemical profile of CXPA included positive staining reactions in the malignant component for AE1/AE3 in 97% of cases, CK7 in 94%, epithelial membrane antigen in 86%, carcinoembryonic antigen in 75%, vimentin in 52%, and S-100 protein in 29%. cxpa 35-39 vimentin Homo sapiens 214-222 11325063-0 2001 Microtubules and vimentin associated filaments (VIFs) in cultured human gingival fibroblasts (HGFs) after exposure to acrolein and acetaldehyde. Acrolein 118-126 vimentin Homo sapiens 17-25 11263984-3 2001 By treating hMSCs with 0.5 mM isobutylmethylxanthine (IBMX)/1 mM dibutyryl cyclic AMP (dbcAMP) for 6 days, about 25% of the hMSCs differentiated into cells with a typical neural cell morphology and with increased levels of both NSE and vimentin. Bucladesine 65-85 vimentin Homo sapiens 236-244 11263984-3 2001 By treating hMSCs with 0.5 mM isobutylmethylxanthine (IBMX)/1 mM dibutyryl cyclic AMP (dbcAMP) for 6 days, about 25% of the hMSCs differentiated into cells with a typical neural cell morphology and with increased levels of both NSE and vimentin. Bucladesine 87-93 vimentin Homo sapiens 236-244 11263984-3 2001 By treating hMSCs with 0.5 mM isobutylmethylxanthine (IBMX)/1 mM dibutyryl cyclic AMP (dbcAMP) for 6 days, about 25% of the hMSCs differentiated into cells with a typical neural cell morphology and with increased levels of both NSE and vimentin. 1-Methyl-3-isobutylxanthine 30-52 vimentin Homo sapiens 236-244 11263984-3 2001 By treating hMSCs with 0.5 mM isobutylmethylxanthine (IBMX)/1 mM dibutyryl cyclic AMP (dbcAMP) for 6 days, about 25% of the hMSCs differentiated into cells with a typical neural cell morphology and with increased levels of both NSE and vimentin. 1-Methyl-3-isobutylxanthine 54-58 vimentin Homo sapiens 236-244 11349537-2 2001 Suspension (5%, w/v) of a commercially available household detergent, Vim Ultra, has been found to be very efficient in destaining polyacrylamide gels without interfering with the resolution of proteins. polyacrylamide 131-145 vimentin Homo sapiens 70-73 11325063-0 2001 Microtubules and vimentin associated filaments (VIFs) in cultured human gingival fibroblasts (HGFs) after exposure to acrolein and acetaldehyde. Acetaldehyde 131-143 vimentin Homo sapiens 17-25 11685846-9 2001 With prolonged ciprofloxacin treatment and with increased doses, there was an increase in dilated rough endoplasmic reticulum, the appearance of phagosomes, and disintegrated bundles of vimentin filaments. Ciprofloxacin 15-28 vimentin Homo sapiens 186-194 11712680-0 2001 Estimation of changes in vimentin filaments induced by etoposide and doxorubicin in human leukemia cell line K-562 by using immunofluorescence microscopy. Etoposide 55-64 vimentin Homo sapiens 25-33 11712680-0 2001 Estimation of changes in vimentin filaments induced by etoposide and doxorubicin in human leukemia cell line K-562 by using immunofluorescence microscopy. Doxorubicin 69-80 vimentin Homo sapiens 25-33 11712680-1 2001 This study was undertaken to examine the influence of etoposide and doxorubicin on the distribution of vimentin in cells of human leukemia cell line K-562 by using immunofluorescence microscopy. Etoposide 54-63 vimentin Homo sapiens 103-111 11712680-1 2001 This study was undertaken to examine the influence of etoposide and doxorubicin on the distribution of vimentin in cells of human leukemia cell line K-562 by using immunofluorescence microscopy. Doxorubicin 68-79 vimentin Homo sapiens 103-111 11712680-8 2001 Immunofluorescence studies on K-562 cells treated with doxorubicin showed that cells incubated with 5 microM/l doxorubicin have much diffuse staining pattern of vimentin with delicate reticular structure and with intense staining near one pool of the cells. Doxorubicin 55-66 vimentin Homo sapiens 161-169 11712680-8 2001 Immunofluorescence studies on K-562 cells treated with doxorubicin showed that cells incubated with 5 microM/l doxorubicin have much diffuse staining pattern of vimentin with delicate reticular structure and with intense staining near one pool of the cells. Doxorubicin 111-122 vimentin Homo sapiens 161-169 11915179-0 2001 The expression of vimentin in HL-60 cells induced with etoposide using immunofluorescence and immunogold methods. Etoposide 55-64 vimentin Homo sapiens 18-26 11915179-2 2001 Changes in the distribution of vimentin were found to be dependent on the concentration of etoposide. Etoposide 91-100 vimentin Homo sapiens 31-39 11915179-5 2001 In control cells and those treated with 0.02, 0.2 and 2 microM/L etoposide, vimentin was seen rather as a ring often with the increased concentration near one pole of the cells. Etoposide 65-74 vimentin Homo sapiens 76-84 11038283-5 2000 We demonstrated that hRCE1 protease cleaved KSKTKC(f)VIM peptides between the C(f) and V positions, generating KSKTKC(f) and the corresponding tripeptides as products. tripeptides 143-154 vimentin Homo sapiens 53-56 11038283-7 2000 We also found that hRCE1 cleaved modified versions of KSKTKC(f)VIM that incorporated either MCA or ABZ fluorescent chromophores at the N-terminus, and quenching-group-containing amino acids at the V or M, but not the I, amino acid positions of VIM. 4-[4-AMINO-6-(5-CHLORO-1H-INDOL-4-YLMETHYL)-[1,3,5]TRIAZIN-2-YLAMINO]-BENZONITRILE 99-102 vimentin Homo sapiens 63-66 10828982-1 2000 The amino acid residues responsible for stable binding of nucleic acids by the intermediate filament (IF) subunit protein vimentin were identified by a combination of enyzmatic and chemical ladder sequencing of photo-cross-linked vimentin-oligodeoxyribonucleotide complexes and analysis by MALDI-TOF mass spectrometry. Oligodeoxyribonucleotides 239-263 vimentin Homo sapiens 122-130 10900195-7 2000 Finally, we show that genistein treatment of Cdc42 and Rac1-expressing cells strongly reduces vimentin collapse, whereas staurosporin, wortmannin, LY-294002, R(p)-cAMP, or RII, the regulatory subunit of protein kinase A, remain ineffective. Genistein 22-31 vimentin Homo sapiens 94-102 10900195-9 2000 These data indicate that Cdc42Hs and Rac1 GTPases control vimentin IF organization involving tyrosine phosphorylation events. Tyrosine 93-101 vimentin Homo sapiens 58-66 11013394-4 2000 In both thrombin- and cytochalasin-treated cells that exhibit a noticeable depletion in WPBs compared to control cells, WPBs located at the cell periphery were found to colocalize with vimentin intermediate filaments, but not with microtubules. Cytochalasins 22-34 vimentin Homo sapiens 185-193 11013394-6 2000 When vimentin filaments were induced to collapse to a perinuclear location by the microtubule-disrupting agent demecolcine, WPBs also translocated to the perinuclear region, where numerous WPBs were found to be localized within the bundles of intermediate-sized filaments. Demecolcine 111-122 vimentin Homo sapiens 5-13 11029050-3 2000 Here we show that SNAP23 associates with vimentin filaments in a Triton X-100 insoluble fraction in fibroblasts in primary culture and HeLa cells. Octoxynol 65-77 vimentin Homo sapiens 41-49 11029050-4 2000 Upon treatment of human fibroblasts with N-ethyl-maleimide, SNAP23 dissociates from vimentin filaments and forms a protein complex with syntaxin 4, a plasma membrane SNARE. Ethylmaleimide 41-58 vimentin Homo sapiens 84-92 10978387-11 2000 Since the cytoskeleton can play an important role in the release of secretory vesicles, the influence of Al on the structure of actin, beta-tubulin and vimentin was investigated by confocal microscopy. Aluminum 105-107 vimentin Homo sapiens 152-160 10948067-5 2000 The induced rearrangements of cellular cytoskeleton (actin or vimentin) are partly prevented by inhibition of protein kinase C or high levels of potassium chloride. Potassium Chloride 145-163 vimentin Homo sapiens 62-70 10987178-11 2000 By comparison with GFAP expression in gliomas and vimentin in meningiomas, the colocalisation of gangliosides and intermediary filament proteins is supposed. Gangliosides 97-109 vimentin Homo sapiens 50-58 10898730-4 2000 Similar results were obtained from measurements on wild-type fibroblasts and endothelial cells after vimentin IFs were disrupted by acrylamide. Acrylamide 132-142 vimentin Homo sapiens 101-109 10892870-16 2000 Western blot analysis of the cytoskeletal protein vimentin (56 kDa) revealed a distinct breakdown product of 48 kDa in ionomycin-treated lenses that was not present when Ca2+ was chelated with EGTA. Ionomycin 119-128 vimentin Homo sapiens 50-58 10892870-16 2000 Western blot analysis of the cytoskeletal protein vimentin (56 kDa) revealed a distinct breakdown product of 48 kDa in ionomycin-treated lenses that was not present when Ca2+ was chelated with EGTA. Egtazic Acid 193-197 vimentin Homo sapiens 50-58 10892870-17 2000 In addition, high-molecular-weight proteins (approximately 115 kDa and 235 kDa) that cross-reacted with the vimentin antibody were observed in ionomycin-treated lenses. Ionomycin 143-152 vimentin Homo sapiens 108-116 10828982-1 2000 The amino acid residues responsible for stable binding of nucleic acids by the intermediate filament (IF) subunit protein vimentin were identified by a combination of enyzmatic and chemical ladder sequencing of photo-cross-linked vimentin-oligodeoxyribonucleotide complexes and analysis by MALDI-TOF mass spectrometry. Oligodeoxyribonucleotides 239-263 vimentin Homo sapiens 230-238 10828982-2 2000 Three tryptic peptides of vimentin (vim(28)(-)(35), vim(36)(-)(49), and vim(50)(-)(63)) were found to be cross-linked to oligo(dG.BrdU)(12). Peptides 14-22 vimentin Homo sapiens 26-34 10828982-7 2000 These three Tyr residues are contained within the two beta-ladder DNA-binding wings proposed for the middle of the vimentin non-alpha-helical head domain. Tyrosine 12-15 vimentin Homo sapiens 115-123 10854071-3 2000 In parental Caski cells, recombinant CR-1 induced a dose-dependent increase of vimentin protein expression within 24 h. Since vimentin expression has been demonstrated to correlate with a more aggressive phenotype in human cervical cancer, the migration capacity of CR-1-transfected or CR-1-treated Caski cells was studied in the Boyden chamber assay. Chromium 37-39 vimentin Homo sapiens 79-87 10854071-3 2000 In parental Caski cells, recombinant CR-1 induced a dose-dependent increase of vimentin protein expression within 24 h. Since vimentin expression has been demonstrated to correlate with a more aggressive phenotype in human cervical cancer, the migration capacity of CR-1-transfected or CR-1-treated Caski cells was studied in the Boyden chamber assay. Chromium 37-39 vimentin Homo sapiens 126-134 10699458-11 2000 When polymerized vimentin and actin were directly depolymerized by sialosylcholesterol and mixed, polymer formation was demonstrated between these two proteins. sialosylcholesterol 67-86 vimentin Homo sapiens 17-25 10777586-6 2000 In vivo DMS footprinting by ligation-mediated PCR delineated the position of guanine residues important to vimentin expression. Guanine 77-84 vimentin Homo sapiens 107-115 10782408-4 2000 Each ES/pPNET exhibited focal positive immunostaining for neuron-specific enolase, diffuse staining for vimentin, and strong cell membrane immunoreactivity for O13 (CD99), the last finding providing the first clue to the diagnosis of ES/pPNET in each case. es/ppnet 5-13 vimentin Homo sapiens 104-112 10699458-11 2000 When polymerized vimentin and actin were directly depolymerized by sialosylcholesterol and mixed, polymer formation was demonstrated between these two proteins. Polymers 5-12 vimentin Homo sapiens 17-25 10699458-13 2000 The results indicate that sialosylcholesterol induces reorganization of the cellular filament network, such as disorganization of vimentin and actin filaments, and provokes their hetero-interaction to form the hetero-filament. sialosylcholesterol 26-45 vimentin Homo sapiens 130-138 10625659-5 2000 Immunofluorescence microscopic analysis demonstrated that cPLA(2)alpha and vimentin colocalized around the perinuclear area in cPLA(2)alpha-overexpressing human embryonic kidney 293 cells following A23187 stimulation. Calcimycin 198-204 vimentin Homo sapiens 75-83 10625659-6 2000 Forcible expression of vimentin in vimentin-deficient SW13 cells augmented A23187-induced arachidonate release. Calcimycin 75-81 vimentin Homo sapiens 23-31 10625659-6 2000 Forcible expression of vimentin in vimentin-deficient SW13 cells augmented A23187-induced arachidonate release. Calcimycin 75-81 vimentin Homo sapiens 35-43 10625659-6 2000 Forcible expression of vimentin in vimentin-deficient SW13 cells augmented A23187-induced arachidonate release. Arachidonic Acid 90-102 vimentin Homo sapiens 23-31 10625659-6 2000 Forcible expression of vimentin in vimentin-deficient SW13 cells augmented A23187-induced arachidonate release. Arachidonic Acid 90-102 vimentin Homo sapiens 35-43 10625659-7 2000 Moreover, overexpression of the vimentin head domain in rat fibroblastic 3Y1 cells exerted a dominant inhibitory effect on arachidonate metabolism, significantly reducing A23187-induced arachidonate release and attendant prostanoid generation. Arachidonic Acid 123-135 vimentin Homo sapiens 32-40 10625659-7 2000 Moreover, overexpression of the vimentin head domain in rat fibroblastic 3Y1 cells exerted a dominant inhibitory effect on arachidonate metabolism, significantly reducing A23187-induced arachidonate release and attendant prostanoid generation. Calcimycin 171-177 vimentin Homo sapiens 32-40 10625659-7 2000 Moreover, overexpression of the vimentin head domain in rat fibroblastic 3Y1 cells exerted a dominant inhibitory effect on arachidonate metabolism, significantly reducing A23187-induced arachidonate release and attendant prostanoid generation. Arachidonic Acid 186-198 vimentin Homo sapiens 32-40 10625659-7 2000 Moreover, overexpression of the vimentin head domain in rat fibroblastic 3Y1 cells exerted a dominant inhibitory effect on arachidonate metabolism, significantly reducing A23187-induced arachidonate release and attendant prostanoid generation. Prostaglandins 221-231 vimentin Homo sapiens 32-40 10625659-8 2000 These results suggest that vimentin is an adaptor for cPLA(2)alpha to function properly during the eicosanoid-biosynthetic process. Eicosanoids 99-109 vimentin Homo sapiens 27-35 11094453-5 2000 Immunologically, Sa is a hapten-carrier antigen in which vimentin is the carrier and citrulline is the hapten. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 17-19 vimentin Homo sapiens 57-65 10663387-5 2000 Human chondrocytes cultivated in CFX-supplemented medium (10, 40, 80 and 160 microg/ml) or Mg(2+)-free medium showed decreased ability to adhere to growth support, cell shape changes, and alterations in actin and vimentin cytoskeleton in a concentration dependent manner. magnesium ion 91-97 vimentin Homo sapiens 213-221 10606512-1 1999 Employing deletion mutant proteins and fluorescein-labeled oligodeoxyribonucleotides in a fluorescence polarization assay, the nucleic acid binding site of the intermediate filament (IF) subunit protein vimentin was localized to the middle of the arginine-rich, non-alpha-helical, N-terminal head domain. Fluorescein 39-50 vimentin Homo sapiens 203-211 10844400-1 2000 In tile present study we seek the presence and possible function of the intermediate filament protein vimentin in adrenomedullary chromaffin cells. chromaffin 130-140 vimentin Homo sapiens 102-110 10844400-3 2000 Vimentin was also shown to be phosphorylated in a calcium-dependent manner by acetylcholine. Calcium 50-57 vimentin Homo sapiens 0-8 10844400-3 2000 Vimentin was also shown to be phosphorylated in a calcium-dependent manner by acetylcholine. Acetylcholine 78-91 vimentin Homo sapiens 0-8 10844400-4 2000 The specific protein phosphatase inhibitor calyculin-A, that has been previously shown to increase vimentin phosphorylation, caused a change in the distribution of vimentin which moved from the Triton X-100 insoluble cytoskeletal preparation to the detergent soluble fraction probably as a result of modifications in filament integrity. calyculin A 43-54 vimentin Homo sapiens 99-107 10844400-4 2000 The specific protein phosphatase inhibitor calyculin-A, that has been previously shown to increase vimentin phosphorylation, caused a change in the distribution of vimentin which moved from the Triton X-100 insoluble cytoskeletal preparation to the detergent soluble fraction probably as a result of modifications in filament integrity. calyculin A 43-54 vimentin Homo sapiens 164-172 10844400-4 2000 The specific protein phosphatase inhibitor calyculin-A, that has been previously shown to increase vimentin phosphorylation, caused a change in the distribution of vimentin which moved from the Triton X-100 insoluble cytoskeletal preparation to the detergent soluble fraction probably as a result of modifications in filament integrity. Octoxynol 194-206 vimentin Homo sapiens 164-172 10844400-5 2000 The possible role of vimentin in secretion was in addition investigated using digitonin-permeabilized cells, in which the specific antibody for vimentin partially inhibited calcium-induced catecholamine release. Digitonin 78-87 vimentin Homo sapiens 144-152 10844400-5 2000 The possible role of vimentin in secretion was in addition investigated using digitonin-permeabilized cells, in which the specific antibody for vimentin partially inhibited calcium-induced catecholamine release. Calcium 173-180 vimentin Homo sapiens 144-152 10844400-5 2000 The possible role of vimentin in secretion was in addition investigated using digitonin-permeabilized cells, in which the specific antibody for vimentin partially inhibited calcium-induced catecholamine release. Catecholamines 189-202 vimentin Homo sapiens 144-152 10844400-6 2000 These results demonstrate the induction of vimentin expression after collagenase digestion in cultured chromaffin cells and suggest that in these conditions this protein is possibly implicated in the regulation of the secretory process through a phosphorylation-dependent mechanism. chromaffin 103-113 vimentin Homo sapiens 43-51 10606512-1 1999 Employing deletion mutant proteins and fluorescein-labeled oligodeoxyribonucleotides in a fluorescence polarization assay, the nucleic acid binding site of the intermediate filament (IF) subunit protein vimentin was localized to the middle of the arginine-rich, non-alpha-helical, N-terminal head domain. Oligodeoxyribonucleotides 59-84 vimentin Homo sapiens 203-211 10606512-1 1999 Employing deletion mutant proteins and fluorescein-labeled oligodeoxyribonucleotides in a fluorescence polarization assay, the nucleic acid binding site of the intermediate filament (IF) subunit protein vimentin was localized to the middle of the arginine-rich, non-alpha-helical, N-terminal head domain. Arginine 247-255 vimentin Homo sapiens 203-211 10574968-4 1999 We also found that an antibody, which specifically recognizes vimentin phosphorylated at Ser-71 by Rho kinase, became immunoreactive after calyculin A treatment. Serine 89-92 vimentin Homo sapiens 62-70 10574968-5 1999 This calyculin A-induced interphase phosphorylation of vimentin at Ser-71 was blocked by Rho kinase inhibitor or by expression of the dominant-negative Rho kinase. Serine 67-70 vimentin Homo sapiens 55-63 10578995-11 1999 Immunocytochemical staining revealed a positive reaction in the cytoplasm of tumor cells for vimentin and desmin in the FNA smear and paraffin section, respectively. Paraffin 134-142 vimentin Homo sapiens 93-101 10539885-1 1999 We report a child with Wiskott-Aldrich syndrome with severe, refractory, symptomatic thrombocytopenia who achieved an excellent response to combination therapy with vincristine 1.5 mg/m(2) x 1 day, intravenous immunoglobulin 1 g/kg x 3 days, and methylprednisolone 25 mg/kg x 3 days (VIM) for 7 years after failing multiple treatments. Vincristine 165-176 vimentin Homo sapiens 284-287 10537054-3 1999 [35S]Methionine labeling of cells showed a significant decline in the level of vimentin in the hypothyroid cultures at all ages from day 5 to 20. Sulfur-35 1-4 vimentin Homo sapiens 79-87 10537054-3 1999 [35S]Methionine labeling of cells showed a significant decline in the level of vimentin in the hypothyroid cultures at all ages from day 5 to 20. Methionine 5-15 vimentin Homo sapiens 79-87 10431405-2 1999 In our investigation primary antibodies directed against vimentin and testosterone by immunoperoxidase technique of biotin-streptoavidin amplified system were used to analyse immunoreactive sites. Biotin 116-122 vimentin Homo sapiens 57-65 10428980-0 1999 Vimentin-dependent utilization of LDL-cholesterol in human adrenal tumor cells is not associated with the level of expression of apoE, sterol carrier protein-2, or caveolin. Cholesterol 38-49 vimentin Homo sapiens 0-8 10417439-7 1999 Factor X IIIa was only expressed on tumor cells around melanin-containing cells, which reacted positively with antibodies to S-100 protein and vimentin. Melanins 55-62 vimentin Homo sapiens 143-151 10401612-4 1999 200 microM H2O2 induced cell contraction after 15 min which disappeared after 1 and 4 h, but was evident again after 24 h. Immediately after exposure, the filamentous structure of vimentin and tubulin disappeared, but normalized after 1 h. After 120 h, the cytoskeleton filaments were coarsened and disorganized, and an abundance of multinucleated giant cells were observed. Hydrogen Peroxide 11-15 vimentin Homo sapiens 180-188 10051752-8 1999 In vivo U-beta6 was associated with neurogenesis and labelled newly committed CNS and PNS neuroblasts expressing neuroepithelial cytoskeletal (nestin and vimentin) and surface markers (the anti-ganglioside supernatant, A2B5 and the polysialic acid neural adhesion molecule, PSA-NCAM), as well as differentiating neurons. u-beta6 8-15 vimentin Homo sapiens 154-162 10094414-6 1999 NF-H coexists with vimentin-type filaments as seen by dual staining and staining of consecutive serial sections of material embedded in paraffin. Paraffin 136-144 vimentin Homo sapiens 19-27 10064706-10 1999 For example, vimentin fibers formed in 0.7 mM phosphate (pH 7.5), 2.5 mM MgCl2, yield a significantly increased number of molecules per cross-section (56 and 84) compared to assembly under standard conditions. Phosphates 46-55 vimentin Homo sapiens 13-21 10064706-10 1999 For example, vimentin fibers formed in 0.7 mM phosphate (pH 7.5), 2.5 mM MgCl2, yield a significantly increased number of molecules per cross-section (56 and 84) compared to assembly under standard conditions. Magnesium Chloride 73-78 vimentin Homo sapiens 13-21 9880545-0 1999 Molecular parameters of type IV alpha-internexin and type IV-type III alpha-internexin-vimentin copolymer intermediate filaments. copolymer 96-105 vimentin Homo sapiens 87-95 10073918-8 1999 In vivo U-beta6 was associated with neurogenesis and labelled newly committed CNS and PNS neuroblasts expressing neuroepithelial cytoskeletal (nestin and vimentin) and surface markers (the anti-ganglioside supernatant, A2B5 and the polysialic acid neural adhesion molecule, PSA-NCAM), as well as differentiating neurons. u-beta6 8-15 vimentin Homo sapiens 154-162 9880545-3 1999 First, we have demonstrated by cross-linking experiments that bacterially expressed forms of alpha-internexin and vimentin form heterodimer molecules in vitro that assemble into copolymer intermediate filaments. copolymer 178-187 vimentin Homo sapiens 114-122 10392297-5 1999 Immunoperoxidase stains on paraffin sections showed staining of the cells for anti-vimentin, but there was no staining for anti-keratin, anti-S-100 protein, anti-desmin, anti-glial fibrillary acidic protein (GFAP), or anti-actin. Paraffin 27-35 vimentin Homo sapiens 83-91 9683537-3 1998 The pattern and distribution of actin, tubulin, and vimentin during neomycin stimulation were analyzed by fluorescence and electron microscopy. Neomycin 68-76 vimentin Homo sapiens 52-60 9819349-3 1998 In a search for carriers capable of transporting the IF protein vimentin into the nucleus, complexes of FITC-vimentin with various DNAs were microinjected into the cytoplasm of cultured cells and the intracellular distribution of the protein was followed by confocal laser scanning microscopy. Fluorescein-5-isothiocyanate 104-108 vimentin Homo sapiens 109-117 9819349-4 1998 The single-stranded oligodeoxyribonucleotides oligo(dG)25, oligo[d(GT)12G] and oligo[d(G3T2A)4G] proved to be excellent nuclear carriers for vimentin. Oligodeoxyribonucleotides 20-45 vimentin Homo sapiens 141-149 9819349-4 1998 The single-stranded oligodeoxyribonucleotides oligo(dG)25, oligo[d(GT)12G] and oligo[d(G3T2A)4G] proved to be excellent nuclear carriers for vimentin. oligo 20-25 vimentin Homo sapiens 141-149 9855349-7 1998 In all 10 cases of S&E nevi, the eosinophilic globules showed a positive reaction for type IV collagen and laminin and a negative reaction for keratin, S100 protein, and vimentin, unlike the colloid bodies of lichen planus, which showed a negative reaction for type IV collagen and laminin and also a strong positive reaction for keratin. Sulfur 19-20 vimentin Homo sapiens 174-182 9828104-7 1998 Total amounts of lamins A/C and cytoplasmic vimentin were reduced by RA treatment. Tretinoin 69-71 vimentin Homo sapiens 44-52 9930055-9 1998 Resin T8100, a glycol methacrylate, enabled satisfactory sectioning, grinding, and histological (toluidine blue, haematoxylin and eosin, and trichromatic and polychromatic stains) and immunohistochemical analyses (alpha smooth muscle actin, von Willebrand factor, vimentin, proliferating cell nuclear antigen, and CD68 (mac 387)). t8100 6-11 vimentin Homo sapiens 264-272 9794428-7 1998 Western blot analysis using an anti-phospho-serine mAb (MO82) reveals that Ser82 in the vimentin is phosphorylated specifically by Ca2+/calmodulin-dependent kinase II through sVCAM-1 activation in the IL-2 dependent T cells. Serine 44-50 vimentin Homo sapiens 88-96 9818471-4 1998 METHODS AND RESULTS: A group of 40 patients with relapsing and/or primary therapy resisting lymphomas (14 NHL, 26 HD) were treated by life saving or stimulating chemotherapy VIM (etopozide, iphosphamide, methotrexate) and MINE (iphosphamide mitoxanthrone, etopozide; mostly NHL). etopozide 179-188 vimentin Homo sapiens 174-177 9763453-2 1998 cGMP regulation of vimentin organization was investigated. Cyclic GMP 0-4 vimentin Homo sapiens 19-27 9763453-12 1998 We propose that, in addition to changes in microfilament and microtubule organization, granule secretion is also accompanied by changes in intermediate filament organization, and that cGMP regulates vimentin filament organization via activation of G-kinase. Cyclic GMP 184-188 vimentin Homo sapiens 199-207 9683542-0 1998 Decreased synthesis of glycosphingolipids in cells lacking vimentin intermediate filaments. Glycosphingolipids 23-41 vimentin Homo sapiens 59-67 9683542-1 1998 We are studying defects in glycosphingolipid synthesis in cells lacking vimentin intermediate filaments (vimentin-). Glycosphingolipids 27-44 vimentin Homo sapiens 72-80 9683542-1 1998 We are studying defects in glycosphingolipid synthesis in cells lacking vimentin intermediate filaments (vimentin-). Glycosphingolipids 27-44 vimentin Homo sapiens 105-113 9683542-7 1998 Vimentin- SW13 cells and embryonic fibroblasts glycosylated [14C]C8-Glc-S-Cer less extensively than their vimentin+ counterparts. Carbon-14 61-64 vimentin Homo sapiens 0-8 9683542-10 1998 The defect in glycolipid synthesis in vimentin- cells probably results from impaired intracellular transport of glycolipids and sphingoid bases between the endosomal/lysosomal pathway and the Golgi apparatus and endoplasmic reticulum. Glycolipids 14-24 vimentin Homo sapiens 38-46 9683542-10 1998 The defect in glycolipid synthesis in vimentin- cells probably results from impaired intracellular transport of glycolipids and sphingoid bases between the endosomal/lysosomal pathway and the Golgi apparatus and endoplasmic reticulum. Glycolipids 112-123 vimentin Homo sapiens 38-46 9683542-10 1998 The defect in glycolipid synthesis in vimentin- cells probably results from impaired intracellular transport of glycolipids and sphingoid bases between the endosomal/lysosomal pathway and the Golgi apparatus and endoplasmic reticulum. sphingoid bases 128-143 vimentin Homo sapiens 38-46 9730429-4 1998 Coexpression of vimentin and Ki67 was found in 52 of 340 vimentin-positive cardiomyocytes. ki67 29-33 vimentin Homo sapiens 57-65 9764805-4 1998 We report that agents which reduced cell attachment to plastic and invasion through fibronectin in vitro (tamoxifen, N-desmethyltamoxifen and 17beta-oestradiol) caused increases in levels of F-actin and vimentin, whereas agents which did not affect attachment or invasion (4-hydroxytamoxifen and dihydrotestosterone) had little or no effect on the cytoskeletal proteins. Tamoxifen 106-115 vimentin Homo sapiens 203-211 9764805-4 1998 We report that agents which reduced cell attachment to plastic and invasion through fibronectin in vitro (tamoxifen, N-desmethyltamoxifen and 17beta-oestradiol) caused increases in levels of F-actin and vimentin, whereas agents which did not affect attachment or invasion (4-hydroxytamoxifen and dihydrotestosterone) had little or no effect on the cytoskeletal proteins. N-desmethyltamoxifen 117-137 vimentin Homo sapiens 203-211 9764805-4 1998 We report that agents which reduced cell attachment to plastic and invasion through fibronectin in vitro (tamoxifen, N-desmethyltamoxifen and 17beta-oestradiol) caused increases in levels of F-actin and vimentin, whereas agents which did not affect attachment or invasion (4-hydroxytamoxifen and dihydrotestosterone) had little or no effect on the cytoskeletal proteins. Estradiol 142-159 vimentin Homo sapiens 203-211 9764805-4 1998 We report that agents which reduced cell attachment to plastic and invasion through fibronectin in vitro (tamoxifen, N-desmethyltamoxifen and 17beta-oestradiol) caused increases in levels of F-actin and vimentin, whereas agents which did not affect attachment or invasion (4-hydroxytamoxifen and dihydrotestosterone) had little or no effect on the cytoskeletal proteins. hydroxytamoxifen 273-291 vimentin Homo sapiens 203-211 9764805-4 1998 We report that agents which reduced cell attachment to plastic and invasion through fibronectin in vitro (tamoxifen, N-desmethyltamoxifen and 17beta-oestradiol) caused increases in levels of F-actin and vimentin, whereas agents which did not affect attachment or invasion (4-hydroxytamoxifen and dihydrotestosterone) had little or no effect on the cytoskeletal proteins. Dihydrotestosterone 296-315 vimentin Homo sapiens 203-211 9645945-4 1998 In addition, an increased tyrosine phosphorylation of vimentin was observed. Tyrosine 26-34 vimentin Homo sapiens 54-62 9642140-0 1998 Rapid fragmentation of vimentin in human skin fibroblasts exposed to tamoxifen: a possible involvement of caspase-3. Tamoxifen 69-78 vimentin Homo sapiens 23-31 9642140-2 1998 Here, we show that TAM dramatically caused degradation of vimentin (VIM) in human skin fibroblasts, in a time and dose dependent manner. Tamoxifen 19-22 vimentin Homo sapiens 58-66 9642140-2 1998 Here, we show that TAM dramatically caused degradation of vimentin (VIM) in human skin fibroblasts, in a time and dose dependent manner. Tamoxifen 19-22 vimentin Homo sapiens 68-71 9642140-3 1998 Addition of caspase-3 inhibitor, Z-DEVD-FMK, inhibited formation of some fragments of VIM, and caspase-3 was proteolytically activated by TAM treatment. benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone 33-43 vimentin Homo sapiens 86-89 9642140-3 1998 Addition of caspase-3 inhibitor, Z-DEVD-FMK, inhibited formation of some fragments of VIM, and caspase-3 was proteolytically activated by TAM treatment. Tamoxifen 138-141 vimentin Homo sapiens 86-89 9642140-4 1998 Expression of functional estrogen receptors were negative in these cells, and neither transcription nor protein synthesis was required for TAM-induced degradation of VIM. Tamoxifen 139-142 vimentin Homo sapiens 166-169 9642140-5 1998 Moreover, quinestrol, an ethinyl estradiol derivative, weakly degraded VIM, whereas neither estradiols nor estriol had any effects. Quinestrol 10-20 vimentin Homo sapiens 71-74 9642140-5 1998 Moreover, quinestrol, an ethinyl estradiol derivative, weakly degraded VIM, whereas neither estradiols nor estriol had any effects. Ethinyl Estradiol 25-42 vimentin Homo sapiens 71-74 9642140-6 1998 Taken together, TAM may induce fragmentation of VIM associated with an activation of caspase-3, which may be attributed to non-genomic actions of TAM. Tamoxifen 16-19 vimentin Homo sapiens 48-51 9642140-6 1998 Taken together, TAM may induce fragmentation of VIM associated with an activation of caspase-3, which may be attributed to non-genomic actions of TAM. Tamoxifen 146-149 vimentin Homo sapiens 48-51 9664674-0 1998 Interaction of vimentin with actin and phospholipids. Phospholipids 39-52 vimentin Homo sapiens 15-23 9545318-2 1998 We showed previously that stable, detyrosinated (Glu) microtubules function to localize vimentin intermediate filaments in fibroblasts (Gurland, G., and Gundersen, G. G. (1995) J. Glutamic Acid 49-52 vimentin Homo sapiens 88-96 9548569-3 1998 After treatment with 5 mM NaF for 2 h, the phosphorylation levels of vimentin and an alkali-resistant 65-kDa phosphoprotein were enhanced, a common phenomenon detected in cells under a variety of stress conditions. Sodium Fluoride 26-29 vimentin Homo sapiens 69-77 10463282-1 1998 Vimentin is transiently expressed in many cells of neuroectodermal origin in the fetal central nervous system and may be demonstrated by immunohistochemistry in paraffin sections. Paraffin 161-169 vimentin Homo sapiens 0-8 9545318-5 1998 To identify candidate proteins that mediate the Glu microtubule-vimentin interaction, we incubated microtubules with microtubule-interacting proteins and saturating levels of antibodies to Glu or tyrosinated (Tyr) tubulin. Glutamic Acid 48-51 vimentin Homo sapiens 64-72 9545318-5 1998 To identify candidate proteins that mediate the Glu microtubule-vimentin interaction, we incubated microtubules with microtubule-interacting proteins and saturating levels of antibodies to Glu or tyrosinated (Tyr) tubulin. Tyrosine 209-212 vimentin Homo sapiens 64-72 9545318-10 1998 By SDS-polyacrylamide gel electrophoresis, a kinesin heavy chain of approximately 120 kDa and a light chain of approximately 64 kDa were detected in vimentin/kinesin pellets. Sodium Dodecyl Sulfate 3-6 vimentin Homo sapiens 149-157 9545318-10 1998 By SDS-polyacrylamide gel electrophoresis, a kinesin heavy chain of approximately 120 kDa and a light chain of approximately 64 kDa were detected in vimentin/kinesin pellets. polyacrylamide 7-21 vimentin Homo sapiens 149-157 9464304-0 1998 On: increased smooth muscle actin, factor XIIIa, and vimentin-positive cells in the papillary dermis of carbon dioxide laser-debrided porcine skin. Carbon Dioxide 104-118 vimentin Homo sapiens 53-61 9516464-2 1998 The Ca2+-induced cross-linking of this cytoskeletal element seems to be mediated by the intrinsic transglutaminase of lens, because the reaction could be blocked at the monomeric state of vimentin by the inclusion of small synthetic substrates of the enzyme dansylcadaverine or dansyl-epsilon-aminocaproyl-Gln-Gln-Ile-Val. dansyl-epsilon-aminocaproyl-gln-gln-ile-val 278-321 vimentin Homo sapiens 188-196 9932502-3 1998 However, the effect of vimentin on triglyceride stability that is observed in preadipose cells is not obviously reflected in adrenal cells or fibroblasts. Triglycerides 35-47 vimentin Homo sapiens 23-31 9932502-6 1998 A key issue that needs to be addressed is whether the effect of vimentin IFs on the stability of triglycerides or the trafficking of GSLs and lysosomal cholesterol is due to a direct participation of vimentin IFs in some aspect of these processes, or perhaps reflects an indirect response of the lipid metabolism of these cells to an effect of vimentin on some other cellular process. Triglycerides 97-110 vimentin Homo sapiens 64-72 9427392-2 1997 Using a co-sedimentation assay, we showed that in vitro binding of alphaB-crystallin to peripherin and vimentin was temperature-dependent. alphab-crystallin 67-84 vimentin Homo sapiens 103-111 9137919-7 1997 1 microM okadaic acid induced a 40- to 70-fold increase in phosphorylation of the intermediate filament protein vimentin in intact cells. Okadaic Acid 9-21 vimentin Homo sapiens 112-120 9514091-3 1998 The (16HBE14o-) cell line which did not show any invasive abilities in the Boyden chamber assay displayed a typical epithelial morphology in monolayer, expressed high levels of E-cadherin and synthesized neither MMP-2 and MT1-MMP nor vimentin. 16hbe14o 5-13 vimentin Homo sapiens 234-242 9299559-9 1997 The intermediate filament protein vimentin co-immunoisolated with expanded polyglutamine fusion proteins. polyglutamine 75-88 vimentin Homo sapiens 34-42 9245720-4 1997 The cloned antigen fusion protein co-migrated with human vimentin of molecular mass 56-58 KD in SDS-PAGE and exhibited immunoreactivity towards monoclonal and polyclonal anti-human vimentin antibodies. Sodium Dodecyl Sulfate 96-99 vimentin Homo sapiens 57-65 9278408-1 1997 Mg2+-induced polymerization of type III intermediate filament proteins vimentin and glial fibrillary acidic protein was studied by transient electric birefringence. magnesium ion 0-4 vimentin Homo sapiens 71-79 9278408-5 1997 At the first stage of polymerization (in 0.3 mM MgCl2 for vimentin and 0.2 mM MgCl2 for glial fibrillary acidic protein), the permanent dipole moment disappeared without a change in length of the particles. Magnesium Chloride 48-53 vimentin Homo sapiens 58-66 9204972-4 1997 Our results indicate that exposure of all three leukemic cell lines to nanomolar concentrations of okadaic acid causes a loss of viability by activation of an apoptotic process accompanied by a marked decrease in the expression of Bcl-2, Bcl-X(L) and Bax at both mRNA and protein level, but not of c-fos, vimentin and epsilon-globin, ruling out a non-specific effect of okadaic acid. Okadaic Acid 99-111 vimentin Homo sapiens 305-313 9208331-3 1997 In CCl4-treated rats, all alpha 1(I) procollagen-producing cells were vimentin positive but cytokeratin negative; over 90% expressed desmin, a marker of rat liver stellate cells. Carbon Tetrachloride 3-7 vimentin Homo sapiens 70-78 9247605-2 1997 We investigated the effects of TPA on the expression of vimentin during the differentiation of THP-1 cells at both the mRNA and the protein level. Tetradecanoylphorbol Acetate 31-34 vimentin Homo sapiens 56-64 9247605-3 1997 On northern blotting analysis, a 2.1 kb vimentin mRNA was up-regulated by TPA. Tetradecanoylphorbol Acetate 74-77 vimentin Homo sapiens 40-48 9247605-4 1997 On western blotting, small vimentin molecules with a molecular mass of approximately 40 kDa were observed in the soluble fraction and increased with TPA-induction of cellular differentiation. Tetradecanoylphorbol Acetate 149-152 vimentin Homo sapiens 27-35 9247605-7 1997 Phenylmethylsulfonyl fluoride inhibited this apparent protease activity against vimentin, suggesting the enzyme involved to be a serine protease. Phenylmethylsulfonyl Fluoride 0-29 vimentin Homo sapiens 80-88 9247605-9 1997 TPA-treated THP-1 cells were found to express a vimentin-filament network based on immunocytochemical analysis using an anti-vimentin monoclonal antibody, V9. Tetradecanoylphorbol Acetate 0-3 vimentin Homo sapiens 48-56 9247605-9 1997 TPA-treated THP-1 cells were found to express a vimentin-filament network based on immunocytochemical analysis using an anti-vimentin monoclonal antibody, V9. Tetradecanoylphorbol Acetate 0-3 vimentin Homo sapiens 125-133 9113208-5 1997 Most CIB were immunopositive only for vimentin, staining more intensely than surrounding cytoplasm in a comparative study using adjacent sections stained with hematoxylin-eosin and vimentin. cib 5-8 vimentin Homo sapiens 38-46 9113208-5 1997 Most CIB were immunopositive only for vimentin, staining more intensely than surrounding cytoplasm in a comparative study using adjacent sections stained with hematoxylin-eosin and vimentin. cib 5-8 vimentin Homo sapiens 181-189 9113208-9 1997 These findings suggest that CIB are mainly composed of abnormally synthesized and arranged vimentin filaments. cib 28-31 vimentin Homo sapiens 91-99 9142693-13 1997 The Ca2+/calmodulin kinase promotes transport of cholesterol to mitochondria and does so under conditions in which phosphorylation of vimentin and myosin light chain occurs. Cholesterol 49-60 vimentin Homo sapiens 134-142 9137463-7 1997 After a two-week treatment with all-trans retinoic acid, all the cells became spindle shaped, vimentin filaments reappeared in the cytoplasm of J82-NVB cells and desmosomes disappeared from the membranes of these cells. Tretinoin 32-55 vimentin Homo sapiens 94-102 8978384-4 1997 Following HOTC exposure to N-methyl-D-aspartate (NMDA), dose-dependent changes occurred in the optical density (OD) values for the astrocytic immunohistochemical [immunostaining (IS)] markers glial fibrillary acidic protein (GFAP) and vimentin. N-Methylaspartate 27-47 vimentin Homo sapiens 235-243 9033265-5 1997 These activities could be transiently down-regulated by vimentin antisense oligonucleotides in MoVi clones and MDA-MB-231 cells (which constitutively co-express keratins and vimentin). Oligonucleotides 75-91 vimentin Homo sapiens 56-64 9033265-5 1997 These activities could be transiently down-regulated by vimentin antisense oligonucleotides in MoVi clones and MDA-MB-231 cells (which constitutively co-express keratins and vimentin). Oligonucleotides 75-91 vimentin Homo sapiens 174-182 9042640-7 1997 There was a significantly higher reactivity to EMA (p = 0.026), a higher reactivity to CAM 5.2 (p = 0.053) and a lower reactivity to vimentin (p = 0.057) in the hyaluronan-producing mesotheliomas as compared to those with normal levels of hyaluronan. Hyaluronic Acid 161-171 vimentin Homo sapiens 133-141 9030781-15 1997 In vivo phosphorylation of vimentin on Ser55 by cdc2/cyclin B is inhibited by roscovitine. Roscovitine 78-89 vimentin Homo sapiens 27-35 9066625-2 1997 These two cell lines represent a model system for progression of mammary carcinoma: MCF-7 is estradiol-dependent for growth, estrogen-receptor positive, tamoxifen responsive, vimentin negative, Adriamycin sensitive and not invasive in vitro or in vivo while MCF-7ADR is estradiol-independent for growth, estrogen-receptor negative, tamoxifen resistant, vimentin positive, Adriamycin resistant and invasive in vitro and in vivo. Estradiol 93-102 vimentin Homo sapiens 175-183 9066625-2 1997 These two cell lines represent a model system for progression of mammary carcinoma: MCF-7 is estradiol-dependent for growth, estrogen-receptor positive, tamoxifen responsive, vimentin negative, Adriamycin sensitive and not invasive in vitro or in vivo while MCF-7ADR is estradiol-independent for growth, estrogen-receptor negative, tamoxifen resistant, vimentin positive, Adriamycin resistant and invasive in vitro and in vivo. Estradiol 93-102 vimentin Homo sapiens 353-361 9006431-10 1997 The IPE cells stained positively with anticytokeratin, S100 protein, and vimentin antibodies. ipe 4-7 vimentin Homo sapiens 73-81 8978384-4 1997 Following HOTC exposure to N-methyl-D-aspartate (NMDA), dose-dependent changes occurred in the optical density (OD) values for the astrocytic immunohistochemical [immunostaining (IS)] markers glial fibrillary acidic protein (GFAP) and vimentin. N-Methylaspartate 49-53 vimentin Homo sapiens 235-243 8978384-10 1997 In contrast, exposure of HOTCs to a noninjurious level of NMDA (1 microM) caused only minor changes in GFAP IS and vimentin IS OD values but a significantly reduced cellular proliferation in all HOTC regions. N-Methylaspartate 58-62 vimentin Homo sapiens 115-123 9044050-0 1997 Heat-shock and cadmium chloride increase the vimentin mRNA and protein levels in U-937 human promonocytic cells. Cadmium Chloride 15-31 vimentin Homo sapiens 45-53 9044050-2 1997 In addition, both heat and cadmium produced an increase in the amount of the intermediate filament protein vimentin, as determined by immunoblot and immunofluorescence assays. Cadmium 27-34 vimentin Homo sapiens 107-115 9044050-6 1997 Finally, it was observed that the rate of decay of vimentin mRNA upon actinomycin D administration was decreased in heat- and cadmium-pretreated cells in comparison to untreated cells. Dactinomycin 70-83 vimentin Homo sapiens 51-59 9044050-6 1997 Finally, it was observed that the rate of decay of vimentin mRNA upon actinomycin D administration was decreased in heat- and cadmium-pretreated cells in comparison to untreated cells. Cadmium 126-133 vimentin Homo sapiens 51-59 9029735-0 1997 The roles of calmodulin, actin, and vimentin in steroid synthesis by adrenal cells. Steroids 48-55 vimentin Homo sapiens 36-44 9029735-3 1997 Electron microscopy and immunofluorescence reveal that lipid droplets in which steroidogenic cholesterol is stored in the cytoplasm are tightly attached to vimentin intermediate filaments. Cholesterol 93-104 vimentin Homo sapiens 156-164 9034607-5 1996 Overexpression of vimentin IFs in the breast carcinoma model leads to augmentation of motility and invasiveness in vitro, which can be transiently down-regulated by treatment with antisense oligonucleotides to vimentin. Oligonucleotides 190-206 vimentin Homo sapiens 18-26 9034607-5 1996 Overexpression of vimentin IFs in the breast carcinoma model leads to augmentation of motility and invasiveness in vitro, which can be transiently down-regulated by treatment with antisense oligonucleotides to vimentin. Oligonucleotides 190-206 vimentin Homo sapiens 210-218 8937470-0 1996 Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells. cucurbitacin E 0-14 vimentin Homo sapiens 51-59 8937470-4 1996 The distribution of vimentin was also altered in cells exposed to cucurbitacin E, as vimentin associated with drug-induced membrane blebs. cucurbitacin E 66-80 vimentin Homo sapiens 20-28 8937470-4 1996 The distribution of vimentin was also altered in cells exposed to cucurbitacin E, as vimentin associated with drug-induced membrane blebs. cucurbitacin E 66-80 vimentin Homo sapiens 85-93 8930631-5 1996 CsA (1.6 micrograms/ml for 10 days) inhibited the growth of keratinocytes, which never reached confluence; most cells appeared small and roundish, only some stained for cytokeratins and few for vimentin. Cyclosporine 0-3 vimentin Homo sapiens 194-202 8960981-4 1996 Antisense oligonucleotide treatment reduced vimentin-immunoreactivity to background levels. Oligonucleotides 10-25 vimentin Homo sapiens 44-52 8960981-5 1996 Moreover, while 90-100% of cultured hippocampal neurons elaborated neurites within the first 24 hr following plating, only 24-30% did so in the presence of vimentin antisense oligonucleotides. Oligonucleotides 175-191 vimentin Homo sapiens 156-164 8949429-7 1996 A significant reduction of the number of vimentin-positive cells (non-keratinocytes) was observed following combined treatment with calcipotriol and clobetasone butyrate. calcipotriene 132-144 vimentin Homo sapiens 41-49 8949429-7 1996 A significant reduction of the number of vimentin-positive cells (non-keratinocytes) was observed following combined treatment with calcipotriol and clobetasone butyrate. clobetasone butyrate 149-169 vimentin Homo sapiens 41-49 8635498-0 1996 Modifications of vimentin filament architecture and vimentin-nuclear interactions by cholesterol oxides in 73/73 endothelial cells. cholesterol oxides 85-103 vimentin Homo sapiens 17-25 8872136-4 1996 Immunoblot analysis confirms that the 160 kDa protein is co-isolated with vimentin during in vivo high salt extraction. Salts 103-107 vimentin Homo sapiens 74-82 8872136-5 1996 Following vinblastine treatment, both the 160 kDa protein and vimentin become localized to perinuclear caps, as do other intermediate filaments and their associated proteins; after vinblastine removal, the immunostaining produced by A2 becomes filamentous. Vinblastine 10-21 vimentin Homo sapiens 62-70 8660925-5 1996 Treatment of HL60 cells with the PKC-specific inhibitor chelerythrine decreased the phosphorylation of vimentin. chelerythrine 56-69 vimentin Homo sapiens 103-111 8754651-3 1996 In the present study, 58 cases of invasive breast carcinomas were tested for vimentin on formaldehyde fixed paraffin embedded sections. Formaldehyde 89-101 vimentin Homo sapiens 77-85 8754651-3 1996 In the present study, 58 cases of invasive breast carcinomas were tested for vimentin on formaldehyde fixed paraffin embedded sections. Paraffin 108-116 vimentin Homo sapiens 77-85 8776888-0 1996 Characterization of disulfide crosslink formation of human vimentin at the dimer, tetramer, and intermediate filament levels. Disulfides 20-29 vimentin Homo sapiens 59-67 8776888-3 1996 We provide conclusive evidence that crosslinking of the cysteine 328 in wild-type vimentin, when in the filamentous or tetrameric forms, occurs outside of the coiled-coil dimer, i.e., between staggered dimer molecules. Cysteine 56-64 vimentin Homo sapiens 82-90 8811737-0 1996 Chemical cross-linking between lysine groups in vimentin oligomers is dependent on local peptide conformations. Lysine 31-37 vimentin Homo sapiens 48-56 8811737-3 1996 In the present study, molecular modeling of the conformations of vimentin molecules indicated that lysine side chains in identical positions in regions of alpha-helix in parallel chains might be unable to be linked because they are on opposite sides of the coiled coil hydrophobic core. Lysine 99-105 vimentin Homo sapiens 65-73 8601602-3 1996 The mitosis-specific vimentin phosphorylation by PKC was dramatically enhanced by treatment with a PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), while no phosphorylation of vimentin by PKC was observed in interphase cells treated with TPA. Tetradecanoylphorbol Acetate 114-150 vimentin Homo sapiens 21-29 8601602-3 1996 The mitosis-specific vimentin phosphorylation by PKC was dramatically enhanced by treatment with a PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), while no phosphorylation of vimentin by PKC was observed in interphase cells treated with TPA. Tetradecanoylphorbol Acetate 152-155 vimentin Homo sapiens 21-29 8601602-3 1996 The mitosis-specific vimentin phosphorylation by PKC was dramatically enhanced by treatment with a PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), while no phosphorylation of vimentin by PKC was observed in interphase cells treated with TPA. Tetradecanoylphorbol Acetate 248-251 vimentin Homo sapiens 21-29 8601602-6 1996 Thus, targeting of activated PKC, coupled with the reorganization of intracellular membranes which contain phospholipids essential for activation, leads to the mitosis-specific phosphorylation of vimentin. Phospholipids 107-120 vimentin Homo sapiens 196-204 8718673-7 1996 Transfection of cells with vimentin cDNA lacking the p34cdc2 phosphorylation site (ser55:ala) effectively prevents mitotic cells from disassembling their IF. Alanine 89-92 vimentin Homo sapiens 27-35 8907703-0 1996 Vimentin in a cold-water fish, the rainbow trout: highly conserved primary structure but unique assembly properties. Water 19-24 vimentin Homo sapiens 0-8 8635498-0 1996 Modifications of vimentin filament architecture and vimentin-nuclear interactions by cholesterol oxides in 73/73 endothelial cells. cholesterol oxides 85-103 vimentin Homo sapiens 52-60 8635498-3 1996 All three cholesterol oxides promoted a redistribution of vimentin filaments that took place well before cell detachment and the occurrence of any detectable sign of cell death. cholesterol oxides 10-28 vimentin Homo sapiens 58-66 8635498-8 1996 These results indicate that the organization of the intermediate-size filament protein vimentin is markedly affected by cholesterol oxides. cholesterol oxides 120-138 vimentin Homo sapiens 87-95 8852378-0 1996 Prenatal cocaine delays astroglial maturation: immunodensitometry shows increased markers of immaturity (vimentin and GAP-43) and decreased proliferation and production of the growth factor S-100. Cocaine 9-16 vimentin Homo sapiens 105-113 8852378-5 1996 Our results demonstrate that prenatal cocaine administration produces decreased cell proliferation as measured by BrdU staining, retarded neurite outgrowth as ascertained by increased Gap-43 immunoreactivity, increased density of vimentin-positive radial glial cells, and diminished tissue S100 beta immunoreactivity. Cocaine 38-45 vimentin Homo sapiens 230-238 8708944-0 1996 Influence of retinoic acid on the expression of cytokeratins, vimentin and ICAM-1 in human gingival epithelia in vitro. Tretinoin 13-26 vimentin Homo sapiens 62-70 8708944-8 1996 The results showed that RA had minor effects on the marker expression of JE but markedly enhanced expression of cytokeratins 8, 18, 19, vimentin and ICAM-1 in OGE. Tretinoin 24-26 vimentin Homo sapiens 136-144 8547187-5 1995 It has been shown that the two structures involved in cholesterol transport (droplets and mitochondria) are both bound to vimentin intermediate filaments in adrenal and Leydig cells. Cholesterol 54-65 vimentin Homo sapiens 122-130 9106385-3 1996 Immunohistochemical phenotypization carried out on paraffin-embedded section revealed that most cells in the neurosphere expressed high levels of vimentin that is normally found in immature neural cells. Paraffin 51-59 vimentin Homo sapiens 146-154 8546227-5 1996 During attachment and spreading on fibronectin, the transfectants containing vimentin and keratins 8 and 18 demonstrated an increase in focal adhesions that stained positive for beta 1 integrin and phosphotyrosine, along with enhanced membrane ruffling and actin stress fiber formation. Phosphotyrosine 198-213 vimentin Homo sapiens 77-85 8991507-0 1996 Pathways of glycosphingolipid biosynthesis in SW13 cells in the presence and absence of vimentin intermediate filaments. Glycosphingolipids 12-29 vimentin Homo sapiens 88-96 8991507-1 1996 We reported previously that the incorporation of sugars into glycosphingolipids (GSL) is diminished in SW13 cells that lack a vimentin intermediate filament (IF) network (vim-) compared to vim+ cells. Sugars 49-55 vimentin Homo sapiens 126-134 8991507-1 1996 We reported previously that the incorporation of sugars into glycosphingolipids (GSL) is diminished in SW13 cells that lack a vimentin intermediate filament (IF) network (vim-) compared to vim+ cells. Glycosphingolipids 61-79 vimentin Homo sapiens 126-134 8991507-1 1996 We reported previously that the incorporation of sugars into glycosphingolipids (GSL) is diminished in SW13 cells that lack a vimentin intermediate filament (IF) network (vim-) compared to vim+ cells. Glycosphingolipids 81-84 vimentin Homo sapiens 126-134 8991507-10 1996 Our observations indicate that vimentin IF facilitate the recycling of GSL and sphingosine, and that the differences between vim+ and vim- cells are predominantly in pathways 2 and 3. Glycosphingolipids 71-74 vimentin Homo sapiens 31-39 8991507-10 1996 Our observations indicate that vimentin IF facilitate the recycling of GSL and sphingosine, and that the differences between vim+ and vim- cells are predominantly in pathways 2 and 3. Sphingosine 79-90 vimentin Homo sapiens 31-39 7589338-0 1995 Ifosfamide, mitoxantrone and etoposide (VIM) as salvage therapy of low toxicity in non-Hodgkin"s lymphoma. Etoposide 29-38 vimentin Homo sapiens 40-43 21552953-0 1995 N-(4-hydroxyphenyl)retinamide induces apoptosis in human leukemia hl-60 cells and mediates vimentin down-regulation. Fenretinide 0-29 vimentin Homo sapiens 91-99 21552953-3 1995 In addition, we have tested the hypothesis that vimentin expression after HPR and RA, taken as indirect evidence of the mechanisms of action of the two retinoids, may be different. Retinoids 152-161 vimentin Homo sapiens 48-56 7497450-2 1995 Immunohistochemically, the paraffin-embedded tumor tissue displayed positive vimentin reactivity and lack of cytokeratin expression, indicating a mesenchymal origin. Paraffin 27-35 vimentin Homo sapiens 77-85 8558596-6 1995 Furthermore, barium and 4-aminopyridine, blockers of this channel, altered the organization and structure of the cytoskeletal proteins actin, tubulin and vimentin. Barium 13-19 vimentin Homo sapiens 154-162 8549595-6 1995 Examination of the Triton X-100-insoluble fraction revealed a clear increase in the phosphorylation level of various proteins, including vimentin. Octoxynol 19-31 vimentin Homo sapiens 137-145 8558596-6 1995 Furthermore, barium and 4-aminopyridine, blockers of this channel, altered the organization and structure of the cytoskeletal proteins actin, tubulin and vimentin. 4-Aminopyridine 24-39 vimentin Homo sapiens 154-162 7560282-4 1995 Vimentin expression in the lateral radial cells decreases markedly during the second week of postnatal life: application of DiI to the ventricular surface reveals that the pial attachment of the lateral radial cells is withdrawn and that the radial processes are gradually pulled back toward the ventricular zone. dilC18(3) dye 124-127 vimentin Homo sapiens 0-8 7821917-1 1995 An immunohistochemical study of 15 ovarian formalin-fixed, paraffin-embedded dysgerminomas showed positive staining of tumor cells for vimentin in all cases. Formaldehyde 43-51 vimentin Homo sapiens 135-143 7625239-13 1995 Before and after treatment the immunoreactive vimentin filaments significantly increased (p < 0.01) after incubation of monocyte with naloxone. Naloxone 137-145 vimentin Homo sapiens 46-54 7852371-4 1995 In 0.2 mM phosphate, 0.5 mM MgCl2, pH 7.5, predominantly tetrameric T-vimentin is found with a rigid structure, no permanent dipole moment, and a length of 63 to 68 nm. Phosphates 10-19 vimentin Homo sapiens 70-78 7852371-4 1995 In 0.2 mM phosphate, 0.5 mM MgCl2, pH 7.5, predominantly tetrameric T-vimentin is found with a rigid structure, no permanent dipole moment, and a length of 63 to 68 nm. Magnesium Chloride 28-33 vimentin Homo sapiens 70-78 7770465-8 1995 Furthermore, JCA-1 cells treated with TPA acquired the expression of cytokeratin 18 and increased the expression of actin and vimentin by 300%. Tetradecanoylphorbol Acetate 38-41 vimentin Homo sapiens 126-134 7534025-3 1995 The expression of CA-125, epithelial membrane antigen (EMA) and vimentin by malignant epithelial mesothelioma cells was hindered by their poor preservation in formalin fixative. Formaldehyde 159-167 vimentin Homo sapiens 64-72 7880731-0 1995 Different vimentin expression in two clones derived from a human colocarcinoma cell line (LoVo) showing different sensitivity to doxorubicin. Doxorubicin 129-140 vimentin Homo sapiens 10-18 7880731-9 1995 Our results show for the first time that cells resistant to doxorubicin express vimentin independently of the mdr glycoprotein. Doxorubicin 60-71 vimentin Homo sapiens 80-88 7780109-4 1995 SDS-PAGE and western blot analysis verified the above observation, in which the vimentin blot pattern of the cybrids was similar to that of reticulocytes, but totally different from that of K562 cells. Sodium Dodecyl Sulfate 0-3 vimentin Homo sapiens 80-88 7803796-0 1995 Cyclic guanosine monophosphate-dependent protein kinase is targeted to intermediate filaments and phosphorylates vimentin in A23187-stimulated human neutrophils. Calcimycin 125-131 vimentin Homo sapiens 113-121 7803796-4 1995 At 3 minutes" stimulation with A23187, colocalization of G-kinase and vimentin was predominantly confined to filaments that extended into the uropod. Calcimycin 31-37 vimentin Homo sapiens 70-78 7803796-5 1995 The time of colocalization of G-kinase and vimentin was reduced in the A23187-stimulated cell from 3 minutes to 1 minute by 8-Br-cGMP. Calcimycin 71-77 vimentin Homo sapiens 43-51 7803796-5 1995 The time of colocalization of G-kinase and vimentin was reduced in the A23187-stimulated cell from 3 minutes to 1 minute by 8-Br-cGMP. 8-bromocyclic GMP 124-133 vimentin Homo sapiens 43-51 7803796-6 1995 Coincident with colocalization was an increase in cGMP levels and transient phosphorylation of vimentin in adhered A23187-stimulated cells. Calcimycin 115-121 vimentin Homo sapiens 95-103 7803796-7 1995 Phosphorylation of vimentin was maximal after 3 minutes with A23187, and was essentially over at 5 minutes. Calcimycin 61-67 vimentin Homo sapiens 19-27 7803796-8 1995 The time of phosphorylation of vimentin was also reduced from 3 minutes to 1 minute when cells were preincubated with 8-Br-cGMP and then stimulated with A23187, which suggests that cyclic adenosine monophosphate (cAMP)-dependent protein kinase does not phosphorylate vimentin in A23187-treated neutrophils. 8-bromocyclic GMP 118-127 vimentin Homo sapiens 31-39 7803796-8 1995 The time of phosphorylation of vimentin was also reduced from 3 minutes to 1 minute when cells were preincubated with 8-Br-cGMP and then stimulated with A23187, which suggests that cyclic adenosine monophosphate (cAMP)-dependent protein kinase does not phosphorylate vimentin in A23187-treated neutrophils. 8-bromocyclic GMP 118-127 vimentin Homo sapiens 267-275 7803796-8 1995 The time of phosphorylation of vimentin was also reduced from 3 minutes to 1 minute when cells were preincubated with 8-Br-cGMP and then stimulated with A23187, which suggests that cyclic adenosine monophosphate (cAMP)-dependent protein kinase does not phosphorylate vimentin in A23187-treated neutrophils. Calcimycin 153-159 vimentin Homo sapiens 31-39 7803796-8 1995 The time of phosphorylation of vimentin was also reduced from 3 minutes to 1 minute when cells were preincubated with 8-Br-cGMP and then stimulated with A23187, which suggests that cyclic adenosine monophosphate (cAMP)-dependent protein kinase does not phosphorylate vimentin in A23187-treated neutrophils. Calcimycin 153-159 vimentin Homo sapiens 267-275 7803796-8 1995 The time of phosphorylation of vimentin was also reduced from 3 minutes to 1 minute when cells were preincubated with 8-Br-cGMP and then stimulated with A23187, which suggests that cyclic adenosine monophosphate (cAMP)-dependent protein kinase does not phosphorylate vimentin in A23187-treated neutrophils. Cyclic AMP 181-211 vimentin Homo sapiens 31-39 7803796-8 1995 The time of phosphorylation of vimentin was also reduced from 3 minutes to 1 minute when cells were preincubated with 8-Br-cGMP and then stimulated with A23187, which suggests that cyclic adenosine monophosphate (cAMP)-dependent protein kinase does not phosphorylate vimentin in A23187-treated neutrophils. Cyclic AMP 181-211 vimentin Homo sapiens 267-275 7803796-8 1995 The time of phosphorylation of vimentin was also reduced from 3 minutes to 1 minute when cells were preincubated with 8-Br-cGMP and then stimulated with A23187, which suggests that cyclic adenosine monophosphate (cAMP)-dependent protein kinase does not phosphorylate vimentin in A23187-treated neutrophils. Cyclic AMP 213-217 vimentin Homo sapiens 31-39 7803796-8 1995 The time of phosphorylation of vimentin was also reduced from 3 minutes to 1 minute when cells were preincubated with 8-Br-cGMP and then stimulated with A23187, which suggests that cyclic adenosine monophosphate (cAMP)-dependent protein kinase does not phosphorylate vimentin in A23187-treated neutrophils. Calcimycin 279-285 vimentin Homo sapiens 31-39 7803796-9 1995 Phosphorylation of vimentin was not observed in nonactivated cells treated only with 8-Br-cGMP. 8-bromocyclic GMP 85-94 vimentin Homo sapiens 19-27 7538357-5 1995 (3) VIM staining was positively related to pCEA staining. pcea 43-47 vimentin Homo sapiens 4-7 7821917-1 1995 An immunohistochemical study of 15 ovarian formalin-fixed, paraffin-embedded dysgerminomas showed positive staining of tumor cells for vimentin in all cases. Paraffin 59-67 vimentin Homo sapiens 135-143 7832290-2 1994 A monoclonal antibody against vimentin (VIM) was used to label SDC. S-[2-(Aminosulfonyl)ethyl]-D-Cysteine 63-66 vimentin Homo sapiens 30-38 7738109-8 1995 Because vimentin IF organization is at least partially dependent on microtubules, the effects of nocodazole and taxol on perinuclear vimentin foci were examined. Paclitaxel 112-117 vimentin Homo sapiens 133-141 7832290-2 1994 A monoclonal antibody against vimentin (VIM) was used to label SDC. S-[2-(Aminosulfonyl)ethyl]-D-Cysteine 63-66 vimentin Homo sapiens 40-43 8001923-8 1994 In our opinion cytokeratin, vimentin, and SP-1 are the most important monoclonal antibodies to aid in the differential diagnosis of PSN-P. psn-p 132-137 vimentin Homo sapiens 28-36 21607449-7 1994 At immunohistochemistry, in paraffin sections, there was strong positivity with the reagents against CD45, CD68, alfa-1-antichymotrypsin and vimentin. Paraffin 28-36 vimentin Homo sapiens 141-149 7819132-3 1994 Etoposide caused little cell damage, as determined by trypan blue exclusion and by apoptotic-like DNA degradation, which was slightly initiated at 48 h. The treatment induced a transient increase in c-fos, c-jun, and jun B mRNA levels, with maximum values at 12 h, a transient increase in collagenase mRNA level, with maximum value at 48 h, and a progressive increase in vimentin and lamin A and C mRNAs. Etoposide 0-9 vimentin Homo sapiens 371-379 7522191-2 1994 In this study we found that most of the vimentin of undifferentiated HL60 and cells induced to differentiate either along the monocytoid pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA) or along the granulocytic pathway by retinoic acid was soluble in a buffer containing 1% Triton X-100/0.6 mol/l KCl in which the intermediate filament proteins usually are not soluble. Tetradecanoylphorbol Acetate 148-184 vimentin Homo sapiens 40-48 7522191-2 1994 In this study we found that most of the vimentin of undifferentiated HL60 and cells induced to differentiate either along the monocytoid pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA) or along the granulocytic pathway by retinoic acid was soluble in a buffer containing 1% Triton X-100/0.6 mol/l KCl in which the intermediate filament proteins usually are not soluble. Tetradecanoylphorbol Acetate 186-189 vimentin Homo sapiens 40-48 7522191-2 1994 In this study we found that most of the vimentin of undifferentiated HL60 and cells induced to differentiate either along the monocytoid pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA) or along the granulocytic pathway by retinoic acid was soluble in a buffer containing 1% Triton X-100/0.6 mol/l KCl in which the intermediate filament proteins usually are not soluble. Tretinoin 228-241 vimentin Homo sapiens 40-48 7522191-2 1994 In this study we found that most of the vimentin of undifferentiated HL60 and cells induced to differentiate either along the monocytoid pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA) or along the granulocytic pathway by retinoic acid was soluble in a buffer containing 1% Triton X-100/0.6 mol/l KCl in which the intermediate filament proteins usually are not soluble. Octoxynol 280-292 vimentin Homo sapiens 40-48 7522191-2 1994 In this study we found that most of the vimentin of undifferentiated HL60 and cells induced to differentiate either along the monocytoid pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA) or along the granulocytic pathway by retinoic acid was soluble in a buffer containing 1% Triton X-100/0.6 mol/l KCl in which the intermediate filament proteins usually are not soluble. Potassium Chloride 303-306 vimentin Homo sapiens 40-48 7522191-3 1994 HL60 vimentin separated on polyacrylamide gel electrophoresis into two proteins of Mr 55,000 and 54,000 that we detected by immunoblotting. polyacrylamide 27-41 vimentin Homo sapiens 5-13 7522191-5 1994 The distribution of both forms of vimentin changed during induction of differentiation by TPA and after 24 h the Mr 54,000 species was predominant. Tetradecanoylphorbol Acetate 90-93 vimentin Homo sapiens 34-42 7522191-6 1994 After an additional 24 h exposure to TPA the relative levels of the two forms of vimentin approached equivalence and a high level of vimentin degradation products was seen. Tetradecanoylphorbol Acetate 37-40 vimentin Homo sapiens 81-89 7522191-6 1994 After an additional 24 h exposure to TPA the relative levels of the two forms of vimentin approached equivalence and a high level of vimentin degradation products was seen. Tetradecanoylphorbol Acetate 37-40 vimentin Homo sapiens 133-141 7522191-7 1994 These results suggest that TPA may increase vimentin degradation along a pathway that has a Mr 54,000 intermediate. Tetradecanoylphorbol Acetate 27-30 vimentin Homo sapiens 44-52 7832980-2 1994 Tryptic phosphopeptide mapping by high-performance liquid chromatography followed by sequential manual Edman degradation and direct peptide sequence analysis revealed that Ser-25, Ser-38, Ser-65, and Ser-71 in the amino-terminal domain and Ser-411 in the carboxyl-terminal domain are the phosphorylation sites in vimentin phosphorylated by this kinase, indicating that autophosphorylation-dependent protein kinase is a potent and unique vimentin kinase. Serine 172-175 vimentin Homo sapiens 313-321 7832980-2 1994 Tryptic phosphopeptide mapping by high-performance liquid chromatography followed by sequential manual Edman degradation and direct peptide sequence analysis revealed that Ser-25, Ser-38, Ser-65, and Ser-71 in the amino-terminal domain and Ser-411 in the carboxyl-terminal domain are the phosphorylation sites in vimentin phosphorylated by this kinase, indicating that autophosphorylation-dependent protein kinase is a potent and unique vimentin kinase. Serine 172-175 vimentin Homo sapiens 437-445 7925714-3 1994 The 56-kDa substrate was identified as vimentin on the basis of its apparent molecular mass, pI, solubility, immunoreactivity, pattern of proteolysis by Lys-C and a partial amino acid sequence. lys-c 153-158 vimentin Homo sapiens 39-47 7925714-6 1994 Hyperactivation of protein kinase C by treatment of retinas with phorbol myristate acetate resulted in the phosphorylation of vimentin in situ, indicating that the phosphorylation is physiologically relevant. Tetradecanoylphorbol Acetate 65-90 vimentin Homo sapiens 126-134 7925714-7 1994 In vitro, purified retinal protein kinase C catalysed the incorporation of nearly 2 mol phosphate per mole of monomeric vimentin. Phosphates 88-97 vimentin Homo sapiens 120-128 7509793-11 1994 We show, in this study, that the intermediate filament protein vimentin is retinoylated in HL60 cells during a 24-h exposure to 100 nM [3H]RA. Tritium 136-138 vimentin Homo sapiens 63-71 7923401-0 1994 Evidence for direct binding of intracellularly distributed ganglioside GM2 to isolated vimentin intermediate filaments in normal and Tay-Sachs disease human fibroblasts. Gangliosides 59-70 vimentin Homo sapiens 87-95 7923401-0 1994 Evidence for direct binding of intracellularly distributed ganglioside GM2 to isolated vimentin intermediate filaments in normal and Tay-Sachs disease human fibroblasts. gm2 71-74 vimentin Homo sapiens 87-95 7923401-1 1994 Although some intracellularly distributed glycosphingolipids are reported to be associated with vimentin intermediate filaments or colchicine sensitive cytoskeleton, no direct evidence for such an association has yet been shown. Glycosphingolipids 42-60 vimentin Homo sapiens 96-104 7923401-2 1994 In this report we demonstrated that the intracellularly distributed ganglioside GM2 directly binds to isolated vimentin intermediate filaments in normal and Tay-Sachs disease human fibroblasts. Gangliosides 68-79 vimentin Homo sapiens 111-119 7923401-2 1994 In this report we demonstrated that the intracellularly distributed ganglioside GM2 directly binds to isolated vimentin intermediate filaments in normal and Tay-Sachs disease human fibroblasts. gm2 80-83 vimentin Homo sapiens 111-119 7923401-4 1994 A double staining of Tay-Sachs fibroblasts with anti-GM2 and anti-vimentin monoclonal antibodies strongly suggested that the GM2 positive filaments are vimentin intermediate filaments. gm2 53-56 vimentin Homo sapiens 152-160 7923401-4 1994 A double staining of Tay-Sachs fibroblasts with anti-GM2 and anti-vimentin monoclonal antibodies strongly suggested that the GM2 positive filaments are vimentin intermediate filaments. gm2 125-128 vimentin Homo sapiens 66-74 7923401-4 1994 A double staining of Tay-Sachs fibroblasts with anti-GM2 and anti-vimentin monoclonal antibodies strongly suggested that the GM2 positive filaments are vimentin intermediate filaments. gm2 125-128 vimentin Homo sapiens 152-160 7923401-5 1994 We then isolated vimentin, in the presence of a detergent and urea, from the normal human skin fibroblasts and murine mastocytoma cells. Urea 62-66 vimentin Homo sapiens 17-25 7923401-6 1994 In a solid phase enzyme-linked immunosorbent assay, the isolated vimentin dose-dependently reacted with both anti-vimentin and anti-GM2 monoclonal antibodies but not with anti-GM3 or anti-GM1 monoclonal antibody. gm2 132-135 vimentin Homo sapiens 65-73 7923401-10 1994 These results clearly indicated that ganglioside GM2 directly binds to vimentin. Gangliosides 37-48 vimentin Homo sapiens 71-79 7923401-10 1994 These results clearly indicated that ganglioside GM2 directly binds to vimentin. gm2 49-52 vimentin Homo sapiens 71-79 7911694-7 1994 Resistance to actinomycin D resulted in increased P-glycoprotein expression, which was associated with a change in desmin and vimentin expression. Dactinomycin 14-27 vimentin Homo sapiens 126-134 7832980-1 1994 The autophosphorylation-dependent protein kinase has been identified as a potent vimentin kinase that incorporates 2 mol of phosphates per mol of protein and generates five major phosphorylation sites in vimentin. Phosphates 124-134 vimentin Homo sapiens 81-89 7832980-1 1994 The autophosphorylation-dependent protein kinase has been identified as a potent vimentin kinase that incorporates 2 mol of phosphates per mol of protein and generates five major phosphorylation sites in vimentin. Phosphates 124-134 vimentin Homo sapiens 204-212 14731640-3 1994 Recent studies have suggested that vimentin-type intermediate filaments may have a role in cholesterol transport. Cholesterol 91-102 vimentin Homo sapiens 35-43 14731640-4 1994 The mechanism by which vimentin filaments affect this process is not known, but future studies promise to provide new insights into both the post-lysosomal transport of cholesterol and the intracellular functions of intermediate filaments. Cholesterol 169-180 vimentin Homo sapiens 23-31 7509793-14 1994 These results indicated that a large fraction of the RA was bound to vimentin by an ester bond. Tretinoin 53-55 vimentin Homo sapiens 69-77 7509793-14 1994 These results indicated that a large fraction of the RA was bound to vimentin by an ester bond. Esters 84-89 vimentin Homo sapiens 69-77 7509793-17 1994 These results indicate that retinoylation is a new modification of vimentin that may be an early event in RA-induced differentiation of HL60 cells. Tretinoin 106-108 vimentin Homo sapiens 67-75 7906647-5 1994 We find that the alpha-crystallins dramatically inhibit the in vitro assembly of GFAP and vimentin in an ATP-independent manner. Adenosine Triphosphate 105-108 vimentin Homo sapiens 90-98 7998834-4 1994 Bidimensional analysis of 32PO4-labeled intermediate filament proteins revealed that the acidic isoform of vimentin and two isoforms of desmin have increased phosphorylation levels in infected cells. 32po4 26-31 vimentin Homo sapiens 107-115 7954854-4 1994 Vimentins with modifications at or near a highly conserved tripeptide, arg-asp-gly (RDG), of the tail domain incorporated into existing IF networks in vimentin-expressing (vim+) cells, but were assembly-incompetent in cells that did not express IF proteins (vim-). Arginine 71-74 vimentin Homo sapiens 151-159 21566910-4 1994 In view of the importance of cell adhesion mechanisms in cell growth and invasion, we sought to determine whether calcium affects the regulation of E-cadherin expression and modifies the relationship between E-cadherin and vimentin expression. Calcium 114-121 vimentin Homo sapiens 223-231 21566910-6 1994 Our results show that calcium enhances cadherin expression in cadherin positive cells and decreases vimentin expression in these cells; in cadherin negative cells, calcium only decreases the expression of vimentin. Calcium 22-29 vimentin Homo sapiens 100-108 21566910-6 1994 Our results show that calcium enhances cadherin expression in cadherin positive cells and decreases vimentin expression in these cells; in cadherin negative cells, calcium only decreases the expression of vimentin. Calcium 22-29 vimentin Homo sapiens 205-213 21566910-6 1994 Our results show that calcium enhances cadherin expression in cadherin positive cells and decreases vimentin expression in these cells; in cadherin negative cells, calcium only decreases the expression of vimentin. Calcium 164-171 vimentin Homo sapiens 205-213 21566910-7 1994 The modifications of E-cadherin and/or vimentin expression suggests that drugs that can modify intracellular calcium may contribute to overcoming the progression of breast tumor cells toward increasingly malignant phenotypes. Calcium 109-116 vimentin Homo sapiens 39-47 7997128-6 1994 The results showed that cab enhanced the immunoreactivity of the following antigens: estrogen receptors (AMAC), progesterone receptors (Novocastra), HMB45, vimentin, leukocyte common antigen, PCNA, p53, MIB-1 (Ki-67) and prostatic specific antigen. cabotegravir 24-27 vimentin Homo sapiens 156-164 8135088-0 1993 Estramustine induces disorganization of microtubules, perinuclear retraction of vimentin and endoplasmatic reticulum, and inhibits cell migration. Estramustine 0-12 vimentin Homo sapiens 80-88 7686566-6 1993 Formalin fixation reduced the percentage of carcinomas and cases of benign disease in which vimentin was detected. Formaldehyde 0-8 vimentin Homo sapiens 92-100 8405422-1 1993 A microsomal endoprotease specifically cleaves isoprenylated peptides of the CAAX motif, such as N-acetyl-S-all-trans-farnesyl-L-cysteine (AFC-VIM), at the isoprenylated cysteine residue. N-acetyl-farnesylcysteine 97-137 vimentin Homo sapiens 143-146 8405422-1 1993 A microsomal endoprotease specifically cleaves isoprenylated peptides of the CAAX motif, such as N-acetyl-S-all-trans-farnesyl-L-cysteine (AFC-VIM), at the isoprenylated cysteine residue. Cysteine 129-137 vimentin Homo sapiens 143-146 7693732-0 1993 Vimentin serves as a phosphate sink during the apparent activation of protein kinases by okadaic acid in mammalian cells. Phosphates 21-30 vimentin Homo sapiens 0-8 7693732-0 1993 Vimentin serves as a phosphate sink during the apparent activation of protein kinases by okadaic acid in mammalian cells. Okadaic Acid 89-101 vimentin Homo sapiens 0-8 7693732-8 1993 These observations strongly suggest that vimentin acts as a phosphate sink by which the effects of "excess kinase activity" inflicted by phosphatases inhibition was attenuated. Phosphates 60-69 vimentin Homo sapiens 41-49 8400238-7 1993 Furthermore, immunogold electron microscopy showed a colocalization of MRP8/MRP14 and the intermediate filament type III protein vimentin in A23187-treated monocytes. Calcimycin 141-147 vimentin Homo sapiens 129-137 8239518-0 1993 Effect of an aryl chloroethyl urea on tubulin and vimentin syntheses in a human breast cancer cell line. aryl chloroethyl urea 13-34 vimentin Homo sapiens 50-58 8239518-4 1993 The results indicate that tBCEU increases the synthesis of at least two proteins present in the cytoskeleton: tubulin and vimentin. 4-tert-butyl-(3-(2-chloroethyl)ureido)benzene 26-31 vimentin Homo sapiens 122-130 8239518-6 1993 These results suggest that the antineoplastic activity of tBCEU is in part related to an alteration in the synthesis pathway of tubulin and vimentin. 4-tert-butyl-(3-(2-chloroethyl)ureido)benzene 58-63 vimentin Homo sapiens 140-148 7688315-6 1993 The first observed alteration in EC cytoskeleton following 12(S)-HETE stimulation is vimentin bundling, followed by the rearrangement and disruption of vinculin-containing adhesion plaques and/or simultaneous redistribution of alpha-actinin and disruption of spectrin. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 59-69 vimentin Homo sapiens 85-93 8181884-8 1994 At high concentrations of hydrocortisone, cytoskeletal elements of smooth muscle cells such as actin, microtubules, and vimentin, were largely altered. Hydrocortisone 26-40 vimentin Homo sapiens 120-128 7693709-7 1993 Since the repeat axial length of the vimentin assemblies (42.6 nm) is less than the molecular length, this means there is an overlap (designated as alignment ACN) of about 1 nm (5-10 residues) between the end of the 2B and beginning of the 1A rod domain segments of similarly directed molecules in the IF. 3-hydroxy-5-estrane-17-carbonitrile 158-161 vimentin Homo sapiens 37-45 8402688-10 1993 Conversely, stimulation of this I-type clone with retinoic acid resulted in an accumulation of N-type cells (which are thought to represent embryonic precursors of sympathetic neurons), decreased vimentin and beta-2-microglobulin, increased neurofilament-M, and a marked elevation in p26-Bcl-2. Tretinoin 50-63 vimentin Homo sapiens 196-204 8269979-9 1993 Vimentin was isolated from 32P-labeled calyculin-A-treated cells and digested with thrombin and alpha-chymotrypsin. Phosphorus-32 27-30 vimentin Homo sapiens 0-8 8373419-1 1993 Synthetic peptide representing the site Ser-41 in vimentin, Leu-Gly-Ser41-Ala42-Leu-Arg44-Arg-Arg-NH2, and its analogs in which Ala-42 was replaced by various amino acids were tested as substrates for cdc2 kinase. Peptides 10-17 vimentin Homo sapiens 50-58 8373419-1 1993 Synthetic peptide representing the site Ser-41 in vimentin, Leu-Gly-Ser41-Ala42-Leu-Arg44-Arg-Arg-NH2, and its analogs in which Ala-42 was replaced by various amino acids were tested as substrates for cdc2 kinase. Serine 40-43 vimentin Homo sapiens 50-58 8395394-3 1993 12-O-Tetradecanoyl phorbol-13-acetate and cytosine arabinoside produced a coordinate and stable stimulation of both vimentin and A/C lamin expression in U-937 cells. Tetradecanoylphorbol Acetate 0-37 vimentin Homo sapiens 116-124 8395394-3 1993 12-O-Tetradecanoyl phorbol-13-acetate and cytosine arabinoside produced a coordinate and stable stimulation of both vimentin and A/C lamin expression in U-937 cells. Cytarabine 42-62 vimentin Homo sapiens 116-124 8395394-4 1993 A stable increase in vimentin expression was also produced by sodium butyrate and by dibutyryl cyclic AMP in U-937 cells and by dimethyl sulfoxide in HL-60 cells. Butyric Acid 62-77 vimentin Homo sapiens 21-29 8395394-4 1993 A stable increase in vimentin expression was also produced by sodium butyrate and by dibutyryl cyclic AMP in U-937 cells and by dimethyl sulfoxide in HL-60 cells. Bucladesine 85-105 vimentin Homo sapiens 21-29 8395394-4 1993 A stable increase in vimentin expression was also produced by sodium butyrate and by dibutyryl cyclic AMP in U-937 cells and by dimethyl sulfoxide in HL-60 cells. Dimethyl Sulfoxide 128-146 vimentin Homo sapiens 21-29 8395394-6 1993 Retinoic acid greatly inhibited vimentin expression in HL-60 cells, but it had little effect on A/C lamin expression. Tretinoin 0-13 vimentin Homo sapiens 32-40 8281497-5 1993 The presence of glycogen in the tumor cells was demonstrated by periodic acid-Schiff (PAS) stain but immunoreactivity for cytokeratin, epithelial membrane antigen, leukocyte common antigen, desmin, actin and neuron-specific enolase were absent; vimentin was present. Glycogen 16-24 vimentin Homo sapiens 245-253 7686566-12 1993 CONCLUSION: There is some loss of vimentin immunoreactivity after formalin fixation. Formaldehyde 66-74 vimentin Homo sapiens 34-42 7507800-3 1993 Immunoblots of Triton X-100 insoluble cytoskeletal fractions show vimentin, and approximately 52 kDa type II and 40/38 kDa type I keratins. Octoxynol 15-27 vimentin Homo sapiens 66-74 8396229-3 1993 CCSK cells consistently exhibited moderate to strong diffuse cytoplasmic positivity for VIM and were negative for F8A, EMA, DES, S-100 and Mac 387. ccsk 0-4 vimentin Homo sapiens 88-91 7683434-4 1993 The intermediate filaments, vimentin, also underwent extensive reorganization (i.e., filament bundling and enrichment to the cell filapodia) following 12(S)-HETE treatment. Hydroxyeicosatetraenoic Acids 157-161 vimentin Homo sapiens 28-36 7683434-5 1993 In vivo phosphorylation studies revealed that 12(S)-HETE induced a hyperphosphorylation of several major cytoskeletal proteins including myosin light chain, actin, and vimentin. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 46-56 vimentin Homo sapiens 168-176 8422577-6 1993 Using a double immunofluorescent staining method, reactive astrocytes which express GABA immunoreactivity were also found to immunostain with either GFAP or vimentin. gamma-Aminobutyric Acid 84-88 vimentin Homo sapiens 157-165 7507800-4 1993 Under "basal" conditions, following prelabeling of cells with [32PO4], vimentin is not significantly phosphorylated, while both type II and I keratins are phosphorylated. 32po4 63-68 vimentin Homo sapiens 71-79 7507800-9 1993 Treatment of [32PO4]-labeled cells with 0.4 microM calyculin A to inhibit types 1 and 2A phosphatase activity causes hyperphosphorylation of both vimentin and keratin, disruption of IF complexes, and actomyosin/cell contraction within 20 min. 32po4 14-19 vimentin Homo sapiens 146-154 7507800-9 1993 Treatment of [32PO4]-labeled cells with 0.4 microM calyculin A to inhibit types 1 and 2A phosphatase activity causes hyperphosphorylation of both vimentin and keratin, disruption of IF complexes, and actomyosin/cell contraction within 20 min. calyculin A 51-62 vimentin Homo sapiens 146-154 8392769-1 1993 The expression of vimentin, as assessed by immunohistochemistry, has been evaluated in 69 medullary carcinomas of the breast: 28 typical medullary carcinomas (TMC), 41 atypical medullary carcinomas (AMC), and 29 invasive ductal carcinomas with subtle medullary features that, however, did not fulfill the strict criteria of TMC or AMC. tmc 159-162 vimentin Homo sapiens 18-26 8305743-5 1993 Furthermore, treatment with sodium butyrate increased the intracellular concentrations of beta-tubulin, vimentin, neurofilaments (M(r) 210,000) and cytokeratin (M(r) 56,000-58,000). Butyric Acid 28-43 vimentin Homo sapiens 104-112 8392769-1 1993 The expression of vimentin, as assessed by immunohistochemistry, has been evaluated in 69 medullary carcinomas of the breast: 28 typical medullary carcinomas (TMC), 41 atypical medullary carcinomas (AMC), and 29 invasive ductal carcinomas with subtle medullary features that, however, did not fulfill the strict criteria of TMC or AMC. 7-amino-4-methylcoumarin 199-202 vimentin Homo sapiens 18-26 8392769-1 1993 The expression of vimentin, as assessed by immunohistochemistry, has been evaluated in 69 medullary carcinomas of the breast: 28 typical medullary carcinomas (TMC), 41 atypical medullary carcinomas (AMC), and 29 invasive ductal carcinomas with subtle medullary features that, however, did not fulfill the strict criteria of TMC or AMC. tmc 324-327 vimentin Homo sapiens 18-26 8392769-1 1993 The expression of vimentin, as assessed by immunohistochemistry, has been evaluated in 69 medullary carcinomas of the breast: 28 typical medullary carcinomas (TMC), 41 atypical medullary carcinomas (AMC), and 29 invasive ductal carcinomas with subtle medullary features that, however, did not fulfill the strict criteria of TMC or AMC. 7-amino-4-methylcoumarin 331-334 vimentin Homo sapiens 18-26 1492922-1 1992 Guanine-rich polynucleotides such as poly(dG), oligo(dG)12-18 or poly(rG) were shown to exert a strong inhibitory effect on vimentin filament assembly and also to cause disintegration of preformed filaments in vitro. Guanine 0-7 vimentin Homo sapiens 124-132 1492922-1 1992 Guanine-rich polynucleotides such as poly(dG), oligo(dG)12-18 or poly(rG) were shown to exert a strong inhibitory effect on vimentin filament assembly and also to cause disintegration of preformed filaments in vitro. Polynucleotides 13-28 vimentin Homo sapiens 124-132 1492922-1 1992 Guanine-rich polynucleotides such as poly(dG), oligo(dG)12-18 or poly(rG) were shown to exert a strong inhibitory effect on vimentin filament assembly and also to cause disintegration of preformed filaments in vitro. poly(dG) 37-45 vimentin Homo sapiens 124-132 1492922-1 1992 Guanine-rich polynucleotides such as poly(dG), oligo(dG)12-18 or poly(rG) were shown to exert a strong inhibitory effect on vimentin filament assembly and also to cause disintegration of preformed filaments in vitro. oligo(dg)12-18 47-61 vimentin Homo sapiens 124-132 1358199-7 1992 The particulate material formed in a temperature-dependent and glutamate-dependent manner contains a large amount of tubulin, actin, and vimentin, but it is not the product of a cold-labile, colchicine-sensitive polymerization process. Glutamic Acid 63-72 vimentin Homo sapiens 137-145 1527066-0 1992 A functional role for vimentin intermediate filaments in the metabolism of lipoprotein-derived cholesterol in human SW-13 cells. Cholesterol 95-106 vimentin Homo sapiens 22-30 1382837-0 1992 Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines. Doxorubicin 69-79 vimentin Homo sapiens 46-54 1382837-0 1992 Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines. Vinblastine 85-96 vimentin Homo sapiens 46-54 1382837-7 1992 Adriamycin-resistant MCF-7 cells express vimentin, have diminished keratin 19 expression, have lost cell adhesion molecule uvomorulin expression, and have reduced formation of desmosomes and tight junctions as determined by reduced immunodetection of their components desmoplakins I and II and zonula occludens (ZO)-1. Doxorubicin 0-10 vimentin Homo sapiens 41-49 1527066-7 1992 These studies indicate that in SW-13 cells, the intracellular movement of LDL-derived cholesterol from the lysosome to the site of esterification is a vimentin-dependent process. Cholesterol 86-97 vimentin Homo sapiens 151-159 1505673-3 1992 Colchicine treatment of the cells, although giving rise to a vimentin collapse on the nucleus, does not result in redistribution of alpha B-cyrstallin. Colchicine 0-10 vimentin Homo sapiens 61-69 1505673-4 1992 When this colchicine treatment is followed by heat shock, alpha B-crystallin relocalizes again to the insoluble fraction, indicating that this relocalization is independent of the collapse of the vimentin network. Colchicine 10-20 vimentin Homo sapiens 196-204 1352781-3 1992 TPA, SB and dbcAMP behave as "early" inducers, in the sense that vimentin mRNA levels are rapidly increased (hour 6) upon drug administration. Tetradecanoylphorbol Acetate 0-3 vimentin Homo sapiens 65-73 1526732-6 1992 Indirect immunofluorescence patterns of fibronectin, actin, tubulin, and vimentin were altered after exposure to vitamin A. Vitamin A 113-122 vimentin Homo sapiens 73-81 1737386-4 1992 Under those conditions, camptothecin induced differentiation, as demonstrated by (a) the capacity of the cells to generate reactive oxygen species, (b) the increase in the surface expression of the leukocyte integrins CD11b/CD18 and CD11c/CD18, (c) the increase in the cellular content of the intermediate filament protein vimentin, and (d) the decrease in the surface expression of the transferrin receptor. Camptothecin 24-36 vimentin Homo sapiens 323-331 1737386-6 1992 Northern blot assays revealed that camptothecin stimulated the expression of CD11b, CD11c, and vimentin at the mRNA level. Camptothecin 35-47 vimentin Homo sapiens 95-103 1542111-3 1992 Exchanges in the central di-arginine and in the two aromatic residues interfere with IF assembly of vimentin in vitro: on assembly under standard assembly conditions (160 mM-NaCl) most of the protein is included in dense aggregates, with a variable and minor proportion of IFs, whereas at lower ionic concentrations short and incomplete IF-like structures are formed. di-arginine 25-36 vimentin Homo sapiens 100-108 1542111-3 1992 Exchanges in the central di-arginine and in the two aromatic residues interfere with IF assembly of vimentin in vitro: on assembly under standard assembly conditions (160 mM-NaCl) most of the protein is included in dense aggregates, with a variable and minor proportion of IFs, whereas at lower ionic concentrations short and incomplete IF-like structures are formed. Sodium Chloride 174-178 vimentin Homo sapiens 100-108 1618899-1 1992 We have conducted experiments to examine the dynamic exchange between subunit and polymer of vimentin intermediate filaments (IF) at steady state through the use of xrhodamine-labeled vimentin in fluorescence recovery after photobleaching (FRAP) analysis. xrhodamine 165-175 vimentin Homo sapiens 93-101 1618899-1 1992 We have conducted experiments to examine the dynamic exchange between subunit and polymer of vimentin intermediate filaments (IF) at steady state through the use of xrhodamine-labeled vimentin in fluorescence recovery after photobleaching (FRAP) analysis. xrhodamine 165-175 vimentin Homo sapiens 184-192 1618899-2 1992 The xrhodamine-vimentin incorporated into the endogenous vimentin IF network after microinjection into fibroblasts and could be visualized with a cooled charge-coupled device (CCD) camera and digital imaging fluorescence microscopy. xrhodamine 4-14 vimentin Homo sapiens 15-23 1618899-2 1992 The xrhodamine-vimentin incorporated into the endogenous vimentin IF network after microinjection into fibroblasts and could be visualized with a cooled charge-coupled device (CCD) camera and digital imaging fluorescence microscopy. xrhodamine 4-14 vimentin Homo sapiens 57-65 1336212-1 1992 We evaluated in human monocytes the effect of high doses of alfentanyl on the expression of vimentin filaments, the phagocytic activity and the membrane display of HLA-DR molecules in the subjects undergoing surgery. Alfentanil 60-70 vimentin Homo sapiens 92-100 1336212-14 1992 High doses of Alfentanyl depress phagocytic function and membrane display of CD35 and HLA-DR molecules in monocyte and induce marked changes in the organization of vimentin filaments in these cells in patients undergoing surgery. Alfentanil 14-24 vimentin Homo sapiens 164-172 1644057-4 1992 Expression of desmin mutants containing deletions in the C-terminal part of the rod in vimentin-free cells results in an increase of the Triton X-100 solubility too. Octoxynol 137-149 vimentin Homo sapiens 87-95 1644057-5 1992 In contrast, if expressed in vimentin-containing cells, these mutant subunits remain in the Triton X-100 insoluble fraction. Octoxynol 92-104 vimentin Homo sapiens 29-37 1601131-2 1992 Recombinant vimentin expressed in E. coli JM 101 cells is cleaved after cell lysis between arginines 11 and 12. Arginine 91-100 vimentin Homo sapiens 12-20 1633851-1 1992 A selective tyrosine fluorescence quenching is found on interaction of vimentin with poly(dT) and poly(rA). Tyrosine 12-20 vimentin Homo sapiens 71-79 1633851-1 1992 A selective tyrosine fluorescence quenching is found on interaction of vimentin with poly(dT) and poly(rA). Poly A 85-90 vimentin Homo sapiens 71-79 1633851-1 1992 A selective tyrosine fluorescence quenching is found on interaction of vimentin with poly(dT) and poly(rA). Thymidine 90-93 vimentin Homo sapiens 71-79 1633851-1 1992 A selective tyrosine fluorescence quenching is found on interaction of vimentin with poly(dT) and poly(rA). Poly A 98-103 vimentin Homo sapiens 71-79 1633851-1 1992 A selective tyrosine fluorescence quenching is found on interaction of vimentin with poly(dT) and poly(rA). Radium 103-106 vimentin Homo sapiens 71-79 1633851-3 1992 The number of nucleotides covered by vimentin upon binding (n) of poly(dT) (50 +/- 4) appeared to be approximately the same as for poly(rA) (44 +/- 4), while the apparent binding constant (K(app)) of the latter is slightly larger (5.0 +/- 2.0 x 10(7) M-1.cm-1 vs. 2.5 +/- 0.5 x 10(7) M-1.cm-1). Poly T 66-74 vimentin Homo sapiens 37-45 1633851-3 1992 The number of nucleotides covered by vimentin upon binding (n) of poly(dT) (50 +/- 4) appeared to be approximately the same as for poly(rA) (44 +/- 4), while the apparent binding constant (K(app)) of the latter is slightly larger (5.0 +/- 2.0 x 10(7) M-1.cm-1 vs. 2.5 +/- 0.5 x 10(7) M-1.cm-1). Poly A 131-139 vimentin Homo sapiens 37-45 1589589-8 1992 Regrowth of vimentin fibers after colchicine treatment was slower with fibroblasts from familial Alzheimer"s disease than that of the control. Colchicine 34-44 vimentin Homo sapiens 12-20 1544369-3 1992 To elucidate mechanisms regulating MEC transdifferentiation, this study investigated the functional relationships among vimentin, Ca2+, and protein kinase C (PKC) in histamine-modulated dermal MEC in vitro. Histamine 166-175 vimentin Homo sapiens 120-128 1544369-6 1992 Histamine, acting through H-1 receptors, produces a rapid (less than 100 ms) and differential elevation of free calcium in each of three cytological compartments defined by the vimentin cytoskeleton in epithelial MEC. Histamine 0-9 vimentin Homo sapiens 177-185 1544369-6 1992 Histamine, acting through H-1 receptors, produces a rapid (less than 100 ms) and differential elevation of free calcium in each of three cytological compartments defined by the vimentin cytoskeleton in epithelial MEC. Calcium 112-119 vimentin Homo sapiens 177-185 1544369-8 1992 The studies reveal that histamine modulation of the MEC phenotype is associated with a rapid patterned reorganization of the vimentin skeleton. Histamine 24-33 vimentin Homo sapiens 125-133 1544369-9 1992 It is hypothesized that histamine induces vimentin post-translational modifications by activating a spatially localized interaction among cytoplasmic free Ca2+, PKC, and the vimentin matrix. Histamine 24-33 vimentin Homo sapiens 42-50 1544369-9 1992 It is hypothesized that histamine induces vimentin post-translational modifications by activating a spatially localized interaction among cytoplasmic free Ca2+, PKC, and the vimentin matrix. Histamine 24-33 vimentin Homo sapiens 174-182 1629250-0 1992 Salt-stable interaction of the amino-terminal head region of vimentin with the alpha-helical rod domain of cytoplasmic intermediate filament proteins and its relevance to protofilament structure and filament formation and stability. Salts 0-4 vimentin Homo sapiens 61-69 1629250-8 1992 Consistent with these observations, vim NT strongly inhibited filament formation in vitro from protofilamentous vimentin. vim nt 36-42 vimentin Homo sapiens 112-120 1352781-3 1992 TPA, SB and dbcAMP behave as "early" inducers, in the sense that vimentin mRNA levels are rapidly increased (hour 6) upon drug administration. Butyric Acid 5-7 vimentin Homo sapiens 65-73 1352781-3 1992 TPA, SB and dbcAMP behave as "early" inducers, in the sense that vimentin mRNA levels are rapidly increased (hour 6) upon drug administration. Bucladesine 12-18 vimentin Homo sapiens 65-73 1352781-7 1992 Moreover, RA is capable of delaying the early induction of vimentin expression caused by TPA and SB, without affecting the normal expression of differentiation markers. Tretinoin 10-12 vimentin Homo sapiens 59-67 1352781-7 1992 Moreover, RA is capable of delaying the early induction of vimentin expression caused by TPA and SB, without affecting the normal expression of differentiation markers. Tetradecanoylphorbol Acetate 89-92 vimentin Homo sapiens 59-67 1352781-7 1992 Moreover, RA is capable of delaying the early induction of vimentin expression caused by TPA and SB, without affecting the normal expression of differentiation markers. Butyric Acid 97-99 vimentin Homo sapiens 59-67 1384135-1 1992 We assessed the efficacy and tolerability of VIM (etoposide/ifosfamide/methotrexate) combination therapy in 24 patients who were failing the treatment protocol of the Lymphomes Non Hodgkiniens (LNH) 84 study. Etoposide 50-59 vimentin Homo sapiens 45-48 1584959-4 1992 Gliafibrillar acid protein (GFAP) and vimentin proved to be of particularly high stability and, consequently, were easily detectable from paraffin material. Paraffin 138-146 vimentin Homo sapiens 38-46 1628323-1 1992 We reported recently that two glycosphingolipids (GSLs), globoside (Gb4) and ganglioside GM3, colocalized with vimentin intermediate filaments of human umbilical vein endothelial cells. Glycosphingolipids 50-54 vimentin Homo sapiens 111-119 1628323-1 1992 We reported recently that two glycosphingolipids (GSLs), globoside (Gb4) and ganglioside GM3, colocalized with vimentin intermediate filaments of human umbilical vein endothelial cells. Glycosphingolipids 30-48 vimentin Homo sapiens 111-119 1628323-1 1992 We reported recently that two glycosphingolipids (GSLs), globoside (Gb4) and ganglioside GM3, colocalized with vimentin intermediate filaments of human umbilical vein endothelial cells. Globosides 57-66 vimentin Homo sapiens 111-119 1628323-1 1992 We reported recently that two glycosphingolipids (GSLs), globoside (Gb4) and ganglioside GM3, colocalized with vimentin intermediate filaments of human umbilical vein endothelial cells. GB4 68-71 vimentin Homo sapiens 111-119 1628323-1 1992 We reported recently that two glycosphingolipids (GSLs), globoside (Gb4) and ganglioside GM3, colocalized with vimentin intermediate filaments of human umbilical vein endothelial cells. Gangliosides 77-88 vimentin Homo sapiens 111-119 1628323-1 1992 We reported recently that two glycosphingolipids (GSLs), globoside (Gb4) and ganglioside GM3, colocalized with vimentin intermediate filaments of human umbilical vein endothelial cells. gm3 89-92 vimentin Homo sapiens 111-119 1628323-6 1992 GM3 ganglioside also colocalized with vimentin in human fibroblasts. G(M3) Ganglioside 0-15 vimentin Homo sapiens 38-46 1727439-4 1992 In addition, it was determined that the intermediate filament protein kinase activity phosphorylated both serine and threonine residues of the intermediate filament proteins, vimentin and GFAP. Serine 106-112 vimentin Homo sapiens 175-183 1727439-4 1992 In addition, it was determined that the intermediate filament protein kinase activity phosphorylated both serine and threonine residues of the intermediate filament proteins, vimentin and GFAP. Threonine 117-126 vimentin Homo sapiens 175-183 1284893-1 1992 The fixation in ethanol or formalin for trypsin digestion in immunohistochemical detection of cytokeratins and vimentin was assessed in a case of ovarian cystadenofibrocarcinoma. Formaldehyde 27-35 vimentin Homo sapiens 111-119 1766255-1 1991 A mathematical model was developed to analyze the leakage of phosphatidylinositol small unilamellar vesicles induced by the intermediate filament protein vimentin and its isolated N-terminal polypeptide. Phosphatidylinositols 61-81 vimentin Homo sapiens 154-162 1657955-6 1991 The filamentous staining pattern for G-kinase and vimentin was enhanced in the presence of 8-Br-cGMP. 8-bromoguanosino-3',5'-cyclic monophosphorothioate 91-100 vimentin Homo sapiens 50-58 1657955-7 1991 Coincident with co-localization of G-kinase and vimentin in adherent neutrophils was a transient increase in cGMP levels and an increase in the phosphorylation of vimentin in fMLP-stimulated cells. Cyclic GMP 109-113 vimentin Homo sapiens 48-56 1657955-9 1991 Phosphorylation of vimentin in the fMLP-stimulated neutrophil was observed in the presence or absence of exogenous cGMP, although in the presence of low concentrations of 8-Br-cGMP a more rapid phosphorylation of vimentin was observed that correlated with the enhanced co-localization of G-kinase and vimentin. Cyclic GMP 115-119 vimentin Homo sapiens 19-27 1657955-9 1991 Phosphorylation of vimentin in the fMLP-stimulated neutrophil was observed in the presence or absence of exogenous cGMP, although in the presence of low concentrations of 8-Br-cGMP a more rapid phosphorylation of vimentin was observed that correlated with the enhanced co-localization of G-kinase and vimentin. 8-bromoguanosino-3',5'-cyclic monophosphorothioate 171-180 vimentin Homo sapiens 19-27 1657955-9 1991 Phosphorylation of vimentin in the fMLP-stimulated neutrophil was observed in the presence or absence of exogenous cGMP, although in the presence of low concentrations of 8-Br-cGMP a more rapid phosphorylation of vimentin was observed that correlated with the enhanced co-localization of G-kinase and vimentin. 8-bromoguanosino-3',5'-cyclic monophosphorothioate 171-180 vimentin Homo sapiens 213-221 1657955-9 1991 Phosphorylation of vimentin in the fMLP-stimulated neutrophil was observed in the presence or absence of exogenous cGMP, although in the presence of low concentrations of 8-Br-cGMP a more rapid phosphorylation of vimentin was observed that correlated with the enhanced co-localization of G-kinase and vimentin. 8-bromoguanosino-3',5'-cyclic monophosphorothioate 171-180 vimentin Homo sapiens 213-221 1719801-2 1991 Monitoring of the quality of antigen preservation and the uniformity of tissue fixation in paraffin-embedded, formaldehyde-fixed tissues is facilitated by the routine use of an antibody to an epitope of vimentin that is partially susceptible to formaldehyde fixation. Paraffin 91-99 vimentin Homo sapiens 203-211 1719801-2 1991 Monitoring of the quality of antigen preservation and the uniformity of tissue fixation in paraffin-embedded, formaldehyde-fixed tissues is facilitated by the routine use of an antibody to an epitope of vimentin that is partially susceptible to formaldehyde fixation. Formaldehyde 110-122 vimentin Homo sapiens 203-211 1719801-2 1991 Monitoring of the quality of antigen preservation and the uniformity of tissue fixation in paraffin-embedded, formaldehyde-fixed tissues is facilitated by the routine use of an antibody to an epitope of vimentin that is partially susceptible to formaldehyde fixation. Formaldehyde 245-257 vimentin Homo sapiens 203-211 1384135-1 1992 We assessed the efficacy and tolerability of VIM (etoposide/ifosfamide/methotrexate) combination therapy in 24 patients who were failing the treatment protocol of the Lymphomes Non Hodgkiniens (LNH) 84 study. Ifosfamide 60-70 vimentin Homo sapiens 45-48 1384135-1 1992 We assessed the efficacy and tolerability of VIM (etoposide/ifosfamide/methotrexate) combination therapy in 24 patients who were failing the treatment protocol of the Lymphomes Non Hodgkiniens (LNH) 84 study. Methotrexate 71-83 vimentin Homo sapiens 45-48 1384135-5 1992 The VIM regimen provided a CR rate of 43% and a PR rate of 17%. Chromium 27-29 vimentin Homo sapiens 4-7 1384135-5 1992 The VIM regimen provided a CR rate of 43% and a PR rate of 17%. Praseodymium 48-50 vimentin Homo sapiens 4-7 1384135-14 1992 This study demonstrates that CR and long disease-free survival are obtainable with the VIM regimen in a small number of patients failing a high-dose doxorubicin-containing first-line treatment. Doxorubicin 149-160 vimentin Homo sapiens 87-90 1939341-3 1991 These findings were associated with a block in appearance of the monocytic phenotype, including inhibition of TPA-induced increases in lamin A, lamin C, and vimentin transcripts. Tetradecanoylphorbol Acetate 110-113 vimentin Homo sapiens 157-165 1724878-5 1991 If different diazonium salts were used for the visualization of the alkaline phosphatase activity (e.g. Fast Red TR Salt, Fast Blue BB Salt) desmin- and vimentin-like immunoreactivity can be demonstrated in the same tissue section in a double sequential staining approach. diazonium salts 13-28 vimentin Homo sapiens 153-161 1920533-1 1991 The phorbol ester 12-O-tetradecanoyl-acetate (TPA) induced prominent and transient changes in the organization of the cytoskeleton in cultured amoeboid microglial cells including redistribution of actin toward the center of the cells and in the subplasmalemmal region, appearance of fine actin filaments, retraction of microtubules (MT), and rearrangement of intermediate filaments (IF) containing vimentin. Phorbol Esters 4-17 vimentin Homo sapiens 398-406 1952072-6 1991 With the Tris-tricine and the Tris-borate gel systems as well as gene sequence data, KS = vimentin greater than beta-tubulin = K7 greater than K18 greater than K19 greater than actin. Tris Tricine 9-21 vimentin Homo sapiens 90-98 1920533-1 1991 The phorbol ester 12-O-tetradecanoyl-acetate (TPA) induced prominent and transient changes in the organization of the cytoskeleton in cultured amoeboid microglial cells including redistribution of actin toward the center of the cells and in the subplasmalemmal region, appearance of fine actin filaments, retraction of microtubules (MT), and rearrangement of intermediate filaments (IF) containing vimentin. 12-o-tetradecanoyl-acetate 18-44 vimentin Homo sapiens 398-406 1920533-1 1991 The phorbol ester 12-O-tetradecanoyl-acetate (TPA) induced prominent and transient changes in the organization of the cytoskeleton in cultured amoeboid microglial cells including redistribution of actin toward the center of the cells and in the subplasmalemmal region, appearance of fine actin filaments, retraction of microtubules (MT), and rearrangement of intermediate filaments (IF) containing vimentin. Tetradecanoylphorbol Acetate 46-49 vimentin Homo sapiens 398-406 1920533-6 1991 Using this antibody, rearrangement of IF involving vimentin phosphorylation was detected within 15 to 60 min of treatment with 50 nM TPA and consisted in the appearance of intense perinuclear fluorescent label. Tetradecanoylphorbol Acetate 133-136 vimentin Homo sapiens 51-59 1920533-8 1991 Immunochemical analysis of nonionic detergent-soluble and -insoluble extracts from untreated and TPA-treated cells revealed no differences in vimentin solubility suggesting that TPA induced vimentin phosphorylation does not result in notable vimentin filament disassembly. Tetradecanoylphorbol Acetate 97-100 vimentin Homo sapiens 190-198 1920533-8 1991 Immunochemical analysis of nonionic detergent-soluble and -insoluble extracts from untreated and TPA-treated cells revealed no differences in vimentin solubility suggesting that TPA induced vimentin phosphorylation does not result in notable vimentin filament disassembly. Tetradecanoylphorbol Acetate 97-100 vimentin Homo sapiens 190-198 1920533-8 1991 Immunochemical analysis of nonionic detergent-soluble and -insoluble extracts from untreated and TPA-treated cells revealed no differences in vimentin solubility suggesting that TPA induced vimentin phosphorylation does not result in notable vimentin filament disassembly. Tetradecanoylphorbol Acetate 178-181 vimentin Homo sapiens 190-198 1920533-8 1991 Immunochemical analysis of nonionic detergent-soluble and -insoluble extracts from untreated and TPA-treated cells revealed no differences in vimentin solubility suggesting that TPA induced vimentin phosphorylation does not result in notable vimentin filament disassembly. Tetradecanoylphorbol Acetate 178-181 vimentin Homo sapiens 190-198 1920533-9 1991 However the extent of vimentin degradation was more prominent in TPA-treated cultures indicating a higher sensitivity of vimentin to proteolytic degradation. Tetradecanoylphorbol Acetate 65-68 vimentin Homo sapiens 22-30 1920533-9 1991 However the extent of vimentin degradation was more prominent in TPA-treated cultures indicating a higher sensitivity of vimentin to proteolytic degradation. Tetradecanoylphorbol Acetate 65-68 vimentin Homo sapiens 121-129 1647766-0 1991 Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid. Okadaic Acid 74-86 vimentin Homo sapiens 0-8 1899071-4 1991 Immunofluorescence staining of fixed, permeabilized HUVECs showed colocalization of globoside and GM3 with vimentin but not with tubulin or actin. gm3 98-101 vimentin Homo sapiens 107-115 1720760-1 1991 We assessed the efficacy of an etoposide, ifosfamide and methotrexate combination therapy (VIM) in 24 patients failing the LNH 84 protocol. Etoposide 31-40 vimentin Homo sapiens 91-94 1720760-1 1991 We assessed the efficacy of an etoposide, ifosfamide and methotrexate combination therapy (VIM) in 24 patients failing the LNH 84 protocol. Methotrexate 57-69 vimentin Homo sapiens 91-94 1899071-3 1991 In this study, we demonstrate that the intracellular globoside and GM3 antigens are associated with the vimentin intermediate filaments of the HUVEC cytoskeleton. gm3 67-70 vimentin Homo sapiens 104-112 2039457-0 1991 Oxidation of thiol in the vimentin cytoskeleton. Sulfhydryl Compounds 13-18 vimentin Homo sapiens 26-34 2039457-1 1991 Sublethal doses of H2O2, which induces oxidative stress, cause substantial alteration to the vimentin cytoskeleton in various cell types. Hydrogen Peroxide 19-23 vimentin Homo sapiens 93-101 2039457-3 1991 Vimentin thiol is oxidized in preference to other cytoskeleton proteins. Sulfhydryl Compounds 9-14 vimentin Homo sapiens 0-8 2039457-4 1991 Immunoblot analysis also demonstrated a loss of reactivity to an anti-vimentin monoclonal antibody under non-reducing conditions, possibly due to thiol-group oxidation. Sulfhydryl Compounds 146-151 vimentin Homo sapiens 70-78 2013762-0 1991 Phorbol myristate acetate and 8-bromo-cyclic AMP-induced phosphorylation of glial fibrillary acidic protein and vimentin in astrocytes: comparison of phosphorylation sites. Tetradecanoylphorbol Acetate 0-25 vimentin Homo sapiens 112-120 2013762-0 1991 Phorbol myristate acetate and 8-bromo-cyclic AMP-induced phosphorylation of glial fibrillary acidic protein and vimentin in astrocytes: comparison of phosphorylation sites. 8-Bromo Cyclic Adenosine Monophosphate 30-48 vimentin Homo sapiens 112-120 2013762-4 1991 Treatment with PMA increased 32P incorporation into all the peptide fragments that were phosphorylated by 8-BR on both vimentin and GFAP; however, PMA also stimulated phosphorylation of additional fragments of both proteins. Tetradecanoylphorbol Acetate 15-18 vimentin Homo sapiens 119-127 2013762-4 1991 Treatment with PMA increased 32P incorporation into all the peptide fragments that were phosphorylated by 8-BR on both vimentin and GFAP; however, PMA also stimulated phosphorylation of additional fragments of both proteins. Phosphorus-32 29-32 vimentin Homo sapiens 119-127 2013762-5 1991 The phosphorylation of vimentin and GFAP resulting from PMA or 8-BR treatment was restricted to serine residues in the N-terminal domain of these proteins. Serine 96-102 vimentin Homo sapiens 23-31 1957650-6 1991 Acridine orange fluorochrome distinguished vimentin/desmin-reactive myofibres that were regenerating from those of developmental myopathies because the RNA fluorescence was strong in regenerating myofibres and in fetal myotubes, but was absent from myofibres in developmental disorders of muscle. Acridine Orange 0-15 vimentin Homo sapiens 43-51 2007620-9 1991 The differences between F-actin and vimentin are optimal for the formation of a composite material with a range of properties that cannot be achieved by either polymer alone. Polymers 160-167 vimentin Homo sapiens 36-44 1850997-0 1991 Evidence that Ser-82 is a unique phosphorylation site on vimentin for Ca2(+)-calmodulin-dependent protein kinase II. Serine 14-17 vimentin Homo sapiens 57-65 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Threonine 85-88 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Arginine 89-92 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Threonine 93-96 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Tyrosine 97-100 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Serine 101-104 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. po4 105-108 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Leucine 112-115 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Glycine 116-119 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Serine 120-123 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Alanine 124-127 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Valine 134-137 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Arginine 138-141 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Leucine 142-145 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Leucine 142-145 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Glutamine 150-153 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Aspartic Acid 154-157 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Serine 120-123 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. po4 162-165 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Valine 169-172 vimentin Homo sapiens 238-246 1850997-2 1991 Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin. Aspartic Acid 173-176 vimentin Homo sapiens 238-246 1989459-5 1991 Immunoperoxidase stains on paraffin sections showed staining of the cells for vimentin only; there was no staining for keratin, S-100 protein, desmin, and actin. Paraffin 27-35 vimentin Homo sapiens 78-86 1989464-6 1991 With formalin-fixed, paraffin-embedded tissue, the majority of OCL-GC and histiocytoid mononuclear cells in both cases showed immunoreactivity using monoclonal antibodies to vimentin and KP-1, with the latter preparation directed against cells of monocytic/histiocytic lineage. Formaldehyde 5-13 vimentin Homo sapiens 174-182 1652247-3 1991 RNA blot assays indicate that butyrate and dbcAMP decrease the expression of ornithine decarboxylase and c-myc genes, and stimulate the expression of the vimentin gene. Butyrates 30-38 vimentin Homo sapiens 154-162 1652247-3 1991 RNA blot assays indicate that butyrate and dbcAMP decrease the expression of ornithine decarboxylase and c-myc genes, and stimulate the expression of the vimentin gene. Bucladesine 43-49 vimentin Homo sapiens 154-162 1899071-4 1991 Immunofluorescence staining of fixed, permeabilized HUVECs showed colocalization of globoside and GM3 with vimentin but not with tubulin or actin. Globosides 84-93 vimentin Homo sapiens 107-115 2271547-0 1990 Specific interaction of the intermediate filament protein vimentin and its isolated N-terminus with negatively charged phospholipids as determined by vesicle aggregation, fusion, and leakage measurements. Phospholipids 119-132 vimentin Homo sapiens 58-66 1792948-1 1991 Two cases with hemichorea and dopa induced dyskinesia (DID) were successfully treated with Vim-Vo thalamotomy. Dihydroxyphenylalanine 30-34 vimentin Homo sapiens 91-94 1792948-5 1991 Regardless of the causes, their choreatic movement was abolished by Vim-Vo thalamotomy affecting mainly Vo after physiological identification of Vim. Vanadium(II) oxide 72-74 vimentin Homo sapiens 68-71 1792948-5 1991 Regardless of the causes, their choreatic movement was abolished by Vim-Vo thalamotomy affecting mainly Vo after physiological identification of Vim. Vanadium(II) oxide 72-74 vimentin Homo sapiens 145-148 1792953-4 1991 Conversely, in the thalamic lesion group (superficial pain dominant), thalamic BNA was higher in CL than in Vim, and markedly decreased in VC. 2-Naphthylamine 79-82 vimentin Homo sapiens 108-111 1935514-3 1991 Immunostaining for factor VIII and vimentin was strongly positive in the malignant spindly polygonal endothelial cells and further supported the NAC diagnosis. nac 145-148 vimentin Homo sapiens 35-43 1726665-5 1991 For both keratin and vimentin there were false-negative findings in the formalin-fixed tumors. Formaldehyde 72-80 vimentin Homo sapiens 21-29 1726665-6 1991 Of these two, vimentin was het most susceptible to formalin fixation. Formaldehyde 51-59 vimentin Homo sapiens 14-22 1707727-10 1990 Thus, bass HCs and MCs share the presence of CA and vimentin epitopes and absence of the NFT 160-kDa epitope. Homocysteine 11-14 vimentin Homo sapiens 52-60 1707626-7 1990 An anti-vimentin antibody and the antibody PM II 40 recognized the same proteins with molecular weights of 54, 52 and 43 kD of SDS-extracted isolated human glomeruli suggesting that vimentin is the glomerular antigen. Sodium Dodecyl Sulfate 127-130 vimentin Homo sapiens 8-16 1707626-7 1990 An anti-vimentin antibody and the antibody PM II 40 recognized the same proteins with molecular weights of 54, 52 and 43 kD of SDS-extracted isolated human glomeruli suggesting that vimentin is the glomerular antigen. Sodium Dodecyl Sulfate 127-130 vimentin Homo sapiens 182-190 2271547-1 1990 The interaction of the intermediate filament protein vimentin and its non-alpha-helical N-terminus with phosphatidylserine and phosphatidylinositol small unilamellar vesicles was investigated by measuring vesicle aggregation, fusion, and leakage. Phosphatidylinositols 127-147 vimentin Homo sapiens 53-61 2271547-6 1990 Intact vimentin also caused leakage of phosphatidylinositol vesicles, at low and high salt concentration. Phosphatidylinositols 39-59 vimentin Homo sapiens 7-15 2271547-6 1990 Intact vimentin also caused leakage of phosphatidylinositol vesicles, at low and high salt concentration. Salts 86-90 vimentin Homo sapiens 7-15 1692028-4 1990 When exposed to hemin or to sodium butyrate, most of the cells became cytokeratin negative within 3 days and showed dispersion of vimentin fibrils. Hemin 16-21 vimentin Homo sapiens 130-138 2279316-2 1990 Alterations of vimentin filaments of CP-activated macrophages stained with FITC-labeled anti-vimentin antibody were observed under immunofluorescence microscope. Fluorescein-5-isothiocyanate 75-79 vimentin Homo sapiens 15-23 2279316-2 1990 Alterations of vimentin filaments of CP-activated macrophages stained with FITC-labeled anti-vimentin antibody were observed under immunofluorescence microscope. Fluorescein-5-isothiocyanate 75-79 vimentin Homo sapiens 93-101 2279316-3 1990 Activated macrophages showed changes with the following characteristics: the intensity of immunofluorescence of vimentin was increased; the filaments of vimentin became thicker than those of normal macrophages when they were treated with colchicine; and the arrangement of vimentin filaments was parallel in direction to the polarization of the activated macrophages. Colchicine 238-248 vimentin Homo sapiens 112-120 2279316-3 1990 Activated macrophages showed changes with the following characteristics: the intensity of immunofluorescence of vimentin was increased; the filaments of vimentin became thicker than those of normal macrophages when they were treated with colchicine; and the arrangement of vimentin filaments was parallel in direction to the polarization of the activated macrophages. Colchicine 238-248 vimentin Homo sapiens 153-161 2279316-3 1990 Activated macrophages showed changes with the following characteristics: the intensity of immunofluorescence of vimentin was increased; the filaments of vimentin became thicker than those of normal macrophages when they were treated with colchicine; and the arrangement of vimentin filaments was parallel in direction to the polarization of the activated macrophages. Colchicine 238-248 vimentin Homo sapiens 153-161 1696263-3 1990 In stably transfected HeLa cells, which contain vimentin filaments, addition of dexamethasone resulted in the initial appearance of mouse vimentin in discrete areas, usually perinuclear, that always corresponded to areas of the human filament network with the most intense fluorescence. Dexamethasone 80-93 vimentin Homo sapiens 48-56 1696263-4 1990 Within 20 h after addition of dexamethasone, the mouse and human vimentin immunofluorescence patterns were identical. Dexamethasone 30-43 vimentin Homo sapiens 65-73 1699393-0 1990 Study of vimentin expression in non-Hodgkin"s lymphoma using paraffin sections. Paraffin 61-69 vimentin Homo sapiens 9-17 2168775-3 1990 PTH (20 nM, 24 h) decreased the de novo biosynthesis of vimentin and alpha-actinin in human bone cells, an effect associated with a rise in intracellular cyclic AMP. Cyclic AMP 154-164 vimentin Homo sapiens 56-64 2345165-2 1990 At low ionic strength, vimentin bound more nucleic acid than the nuclear lamins and showed a preference for G-containing nucleic acids. g-containing nucleic acids 108-134 vimentin Homo sapiens 23-31 2345165-6 1990 Vimentin, lamin A, and lamin C specifically bound a synthetic oligonucleotide human (vertebrate) telomere model. Oligonucleotides 62-77 vimentin Homo sapiens 0-8 1698749-4 1990 The cryostat-microwave technique appears to be well-suited for the demonstration of intermediate filament proteins: the sensitivity of monoclonal antibodies directed against keratins and vimentin can be substantially increased using the ethanol based fixative Kryofix. Ethanol 237-244 vimentin Homo sapiens 187-195 2197590-5 1990 There was evidence of hyaluronic acid secretion and immunohistochemical staining was strong for vimentin, focal for epithelial membrane antigen and S-100 protein, and weak for neuron-specific-enolase. Hyaluronic Acid 22-37 vimentin Homo sapiens 96-104 1692028-4 1990 When exposed to hemin or to sodium butyrate, most of the cells became cytokeratin negative within 3 days and showed dispersion of vimentin fibrils. Butyric Acid 28-43 vimentin Homo sapiens 130-138 1692028-5 1990 Upon exposure to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), the amount of both vimentin and cytokeratin appeared to be greatly increased within 3 days and was found both in dispersed cytoplasmic fibrils, in large spherical, eccentric aggregates, as well as in cytoplasmic fibrils in cells spreading on fibronectin. Phorbol Esters 21-34 vimentin Homo sapiens 98-106 1692028-5 1990 Upon exposure to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), the amount of both vimentin and cytokeratin appeared to be greatly increased within 3 days and was found both in dispersed cytoplasmic fibrils, in large spherical, eccentric aggregates, as well as in cytoplasmic fibrils in cells spreading on fibronectin. Tetradecanoylphorbol Acetate 35-71 vimentin Homo sapiens 98-106 1692028-5 1990 Upon exposure to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), the amount of both vimentin and cytokeratin appeared to be greatly increased within 3 days and was found both in dispersed cytoplasmic fibrils, in large spherical, eccentric aggregates, as well as in cytoplasmic fibrils in cells spreading on fibronectin. Tetradecanoylphorbol Acetate 73-76 vimentin Homo sapiens 98-106 2109773-5 1990 Immunocytochemical analysis of the high salt-stable cytoskeletons from B cells stimulated with anti-Ig revealed an increased accumulation of vimentin in the cytoskeleton compared to nontreated controls. Salts 40-44 vimentin Homo sapiens 141-149 2109773-10 1990 These observations established a relationship between increased content of vimentin in the cytoskeleton and the formation of EFA. efa 125-128 vimentin Homo sapiens 75-83 2279265-1 1990 The presence of vimentin and S-100 protein in cat Pacinian corpuscles of cat mesentery has been investigated immunohistochemically (streptavidin-biotin method) using monoclonal antibodies. Biotin 145-151 vimentin Homo sapiens 16-24 2324766-3 1990 We report, in GAN fibroblasts, inhibition of vimentin filament aggregation by dithiothreitol and penicillamine, sulfhydryl donor compounds which stabilize thiols. Dithiothreitol 78-92 vimentin Homo sapiens 45-53 2324766-3 1990 We report, in GAN fibroblasts, inhibition of vimentin filament aggregation by dithiothreitol and penicillamine, sulfhydryl donor compounds which stabilize thiols. Penicillamine 97-110 vimentin Homo sapiens 45-53 2324766-3 1990 We report, in GAN fibroblasts, inhibition of vimentin filament aggregation by dithiothreitol and penicillamine, sulfhydryl donor compounds which stabilize thiols. Sulfhydryl Compounds 112-122 vimentin Homo sapiens 45-53 2324766-3 1990 We report, in GAN fibroblasts, inhibition of vimentin filament aggregation by dithiothreitol and penicillamine, sulfhydryl donor compounds which stabilize thiols. Sulfhydryl Compounds 155-161 vimentin Homo sapiens 45-53 2082832-0 1990 Vimentin expression in normal human keratinocytes grown in serum-free defined MCDB 153 medium. mcdb 153 medium 78-93 vimentin Homo sapiens 0-8 2082832-1 1990 We have shown that subcultured keratinocytes derived from normal human skin and grown on plastic in serum-free defined medium (MCDB 153, with 0.1 mM Ca2+ concentration) synthesize vimentin. Cariel, culture medium 127-135 vimentin Homo sapiens 180-188 2328771-0 1990 The induction of vimentin gene expression by sodium butyrate in human promonocytic leukemia U937 cells. Butyric Acid 45-60 vimentin Homo sapiens 17-25 2328771-2 1990 At the same time, butyrate greatly induced the expression at the mRNA level of the vimentin gene. Butyrates 18-26 vimentin Homo sapiens 83-91 2328771-5 1990 Experiments in the presence of cycloheximide suggested that vimentin induction is probably a direct response to the action of butyrate, not mediated by the prior induction of other gene products. Cycloheximide 31-44 vimentin Homo sapiens 60-68 2328771-5 1990 Experiments in the presence of cycloheximide suggested that vimentin induction is probably a direct response to the action of butyrate, not mediated by the prior induction of other gene products. Butyrates 126-134 vimentin Homo sapiens 60-68 2373288-6 1990 We found a clear, reversible correlation between proliferation, determined by incorporation of [3H]-TdR, and induction of vimentin in the luminal epithelial cells. Tritium 96-98 vimentin Homo sapiens 122-130 2351153-3 1990 In this study, we show by both, hybridization analysis of RNA and immunoblotting that an enhanced expression of the intermediate filament (IF) subunit proteins vimentin, lamin A and lamin C accompanied the TPA-induced differentiation process. Tetradecanoylphorbol Acetate 206-209 vimentin Homo sapiens 160-168 1689555-10 1990 Of more practical importance, the combined absence of CK, EMA, and vimentin in formalin-fixed, paraffin-embedded CCTL virtually precludes confusion with renal cell carcinoma. cctl 113-117 vimentin Homo sapiens 67-75 2188740-3 1990 In the presence of retinoic acid the fibrillar vimentin immunoreactivity diminished rapidly, while it was increased when the cells were exposed to hemin or butyric acid. Tretinoin 19-32 vimentin Homo sapiens 47-55 2188740-3 1990 In the presence of retinoic acid the fibrillar vimentin immunoreactivity diminished rapidly, while it was increased when the cells were exposed to hemin or butyric acid. Hemin 147-152 vimentin Homo sapiens 47-55 2188740-4 1990 In the presence of a tumor promoter (TPA), the HEL cells maintained their heterogenous vimentin immunoreactivity, but some cells showed large bundles of cytoplasmic vimentin fibrils. Tetradecanoylphorbol Acetate 37-40 vimentin Homo sapiens 87-95 2188740-4 1990 In the presence of a tumor promoter (TPA), the HEL cells maintained their heterogenous vimentin immunoreactivity, but some cells showed large bundles of cytoplasmic vimentin fibrils. Tetradecanoylphorbol Acetate 37-40 vimentin Homo sapiens 165-173 33939900-7 2021 In the presence of simvastatin migratory abilities and vimentin expression is diminished while E-cadherin expression is increased. Simvastatin 19-30 vimentin Homo sapiens 55-63 33793771-9 2021 Furthermore, the miR-424-5p mimic downregulated vimentin and upregulated E-cadherin in 5-fluorouracil-resistant HT-29 cells, whereas the miR-424-5p inhibitor exhibited opposite effects. Fluorouracil 87-101 vimentin Homo sapiens 48-56 34979376-12 2022 MiR-369-5p inhibited the viability, proliferation, migration and invasion of HCC cells, increased E-cadherin level and decreased N-cadherin and Vimentin expressions. mir-369-5p 0-10 vimentin Homo sapiens 144-152 33858283-10 2021 The metastasis promoting effects of LOC648987 on ACHN and 786-O cells were verified by transwell migration assays, which depended on vimentin and MMP-9 to regulate the epithelial-mesenchymal transition. loc648987 36-45 vimentin Homo sapiens 133-141 26743134-5 2016 Increased nuclear STAT3, p-STAT3 and its downstream target proteins, cyclin D1, vimentin and MMP2, were shown to be underling mechanisms of high glucose stimulation. Glucose 145-152 vimentin Homo sapiens 80-88 24222891-8 2013 Furthermore, MESCM maintained a significantly higher percentage of PCK-/ Vim+ cells and exhibited a significant upregulation of NC markers and corneal epithelial SC markers (K15, Bmi-1, and Msi-1) than SHEM. mescm 13-18 vimentin Homo sapiens 73-76 34848469-11 2021 Protein level analysis further showed that pongamol exerted its anti-metastasis effect by inhibiting EMT, as indicated by a decrease of several mesenchymal proteins (N-cadherin, vimentin, Snail, and Slug). pongamol 43-51 vimentin Homo sapiens 178-186 34931497-4 2021 METHODS: Herein, we developed a proximal renal tubule-targeting gene delivery system based on alternative copolymer (PS) of sorbitol and polyethyleneimine (PEI), modified with vimentin-specific chitobionic acid (CA), producing PS-conjugated CA (PSC) for targeting toward vimentin-expressing cells in the kidneys. chitobionic acid 194-210 vimentin Homo sapiens 176-184 34903321-6 2022 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers, increasing alpha-SMA, vimentin, and MMP-9 expression and decreasing E-cadherin expression, with changes in cell morphology. Tetradecanoylphorbol Acetate 15-51 vimentin Homo sapiens 126-134 34903321-6 2022 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers, increasing alpha-SMA, vimentin, and MMP-9 expression and decreasing E-cadherin expression, with changes in cell morphology. Tetradecanoylphorbol Acetate 53-56 vimentin Homo sapiens 126-134 34903321-9 2022 Inhibition of aurora kinase A blocked TPA-induced vimentin and MMP-9 expression, and decreased E-cadherin expression. Tetradecanoylphorbol Acetate 38-41 vimentin Homo sapiens 50-58 34912457-12 2021 The molecular mechanism showed that sufentanil could upregulate the expression of E-cadherin and inhibit the expression of vimentin. Sufentanil 36-46 vimentin Homo sapiens 123-131 34747314-5 2021 The up regulation of miR-138 would lead to the high expression of E-cad and the low expression of N-cad, vim and SEMA4C, and the vitality and invasion of BC cells would decrease. mir-138 21-28 vimentin Homo sapiens 105-108 34747314-6 2021 The down regulation of miR-138 would lead to the low expression of E-cad and the high expression of N-cad, vim and SEMA4C, and the vitality and invasion of BC cells would increase. mir-138 23-30 vimentin Homo sapiens 107-110 34747314-7 2021 miR-138 targeted regulation of SEMA4C can promote the expression of N-cad, inhibit the expression of E-cad, vim and SEMA4C, reverse the EMT of BC cells, and inhibit the activity and invasion of BC cells. mir-138 0-7 vimentin Homo sapiens 108-111 34705053-8 2021 We found that 2-DG therapy mitigated CIA pathology by intercepting joint F480+iNOS+MPhi, Vimentin+ fibroblast and CD3+T cell trafficking along with downregulation of IRFs and glycolytic intermediates. Deoxyglucose 14-18 vimentin Homo sapiens 89-97 34880599-5 2021 Methods: The effects of Ventilagolin on migration, invasion, Pim-1 and EMT-related proteins (eg, E-cadherin, N-cadherin, Vimentin) expression were assessed by scratch wound healing, Transwell, qRT-PCR and Western blot assays, respectively. ventilagolin 24-36 vimentin Homo sapiens 121-129 34880599-12 2021 In vivo experiments showed that Ventilagolin could effectively suppress HCC tumor growth, downregulate Pim-1, N-cadherin and Vimentin expression, and upregulate E-cadherin expression. ventilagolin 32-44 vimentin Homo sapiens 125-133 34488496-6 2021 Second, Western blot and RT-qPCR assay were used to detect the expressions of EMT-related markers (ZEB1, vimentin, E-cadherin, and N-cadherin) in Cd-exposed CRC cells. Cadmium 146-148 vimentin Homo sapiens 105-113 34488496-10 2021 In addition, Cd up-regulated the expressions of N-cadherin, vimentin, and ZEB1, while it down-regulated that of E-cadherin in CRC cells. Cadmium 13-15 vimentin Homo sapiens 60-68 34674612-7 2021 In addition, miR-149-3p suppressed epithelial-mesenchymal transition in U-937 cells, as demonstrated by the miR-149-3p agomir-induced increase in E-cadherin expression and decrease in vimentin expression. mir-149-3p 13-23 vimentin Homo sapiens 184-192 34674612-7 2021 In addition, miR-149-3p suppressed epithelial-mesenchymal transition in U-937 cells, as demonstrated by the miR-149-3p agomir-induced increase in E-cadherin expression and decrease in vimentin expression. mir-149-3p 108-118 vimentin Homo sapiens 184-192 34743769-0 2021 blaVIM in wastewater drains: A hidden circulation of VIM-producing Enterobacterales in the hospital setting? blavim 0-6 vimentin Homo sapiens 53-56 34627777-7 2021 Likewise, erlotinib, an EGFR inhibitor, and NU7441, a DNA-PK inhibitor increased the expression of E-cadherin and decreased the level of vimentin. Erlotinib Hydrochloride 10-19 vimentin Homo sapiens 137-145 34627777-7 2021 Likewise, erlotinib, an EGFR inhibitor, and NU7441, a DNA-PK inhibitor increased the expression of E-cadherin and decreased the level of vimentin. 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one 44-50 vimentin Homo sapiens 137-145 34357837-9 2021 In vitro, curcumin attenuated cell proliferation, suppressed the expression of vimentin and TLR4, and increased the expression of E-cadherin and BAMBI in BPH-1 cells. Curcumin 10-18 vimentin Homo sapiens 79-87 34357837-10 2021 Furthermore, BAMBI knockdown reversed the expression of vimentin and E-cadherin induced by curcumin. Curcumin 91-99 vimentin Homo sapiens 56-64 34481015-0 2021 Butein exhibits anti-tumor effect through intrinsic pathway of apoptosis, vimentin proteolysis, and inhibition of cancer stem cell population in the human papillary thyroid cancer cell line. butein 0-6 vimentin Homo sapiens 74-82 34481015-8 2021 Butein induces caspase-3 mediated proteolysis of vimentin. butein 0-6 vimentin Homo sapiens 49-57 34481015-9 2021 Vimentin and glycolysis are essential for maintaining CSCs; therefore, aldeflour assay and side population assay were performed to investigate the effect of butein on CSCs. butein 157-163 vimentin Homo sapiens 0-8 34481015-11 2021 Here we report a novel mechanism of butein mediated inhibition of NPA cells migration by suppressing vimentin phosphorylation and its subsequent proteolysis. butein 36-42 vimentin Homo sapiens 101-109 34942984-7 2021 Furthermore, in paclitaxel-resistant breast cancer cell lines, MCF-7R and MDA-MB-231R, a combination of JI017 and paclitaxel overcame paclitaxel resistance by blocking epithelial-mesenchymal transition (EMT) processes, such as the downregulation of E-cadherin expression and the upregulation of HIF-1alpha, vimentin, Snail, and Slug expression. ji017 104-109 vimentin Homo sapiens 307-315 34942984-7 2021 Furthermore, in paclitaxel-resistant breast cancer cell lines, MCF-7R and MDA-MB-231R, a combination of JI017 and paclitaxel overcame paclitaxel resistance by blocking epithelial-mesenchymal transition (EMT) processes, such as the downregulation of E-cadherin expression and the upregulation of HIF-1alpha, vimentin, Snail, and Slug expression. Paclitaxel 114-124 vimentin Homo sapiens 307-315 34789743-7 2021 The results showed that F7 and SP peptides not only specifically penetrated into cytoplasm of SAS cells but also bound to EMT derived cells and CSCs with high nucleolin and vimentin expression. TFF2 protein, human 31-33 vimentin Homo sapiens 173-181 34509725-6 2021 The functions of the AL592284.1/miR-30a-5p/Vimentin axis in CC cells was clarified by rescue assays. al592284 21-29 vimentin Homo sapiens 43-51 34761889-0 2021 Twist and Vimentin protein expression in colored cancer tissues and its relationship with oxaliplatin-based reactive reactive chemotherapeutic resistance. Oxaliplatin 90-101 vimentin Homo sapiens 10-18 34509725-9 2021 Luciferase reporter assay confirmed that miR-30a-5p/Vimentin regulatory axis is the direct downstream of AL592284.1. al592284 105-113 vimentin Homo sapiens 52-60 34509725-10 2021 Rescue experiments indicated that AL592284.1 induced overexpression of Vimentin via sponging miR-30a-5p, resulting in the promotion of CC progression. al592284 34-42 vimentin Homo sapiens 71-79 34509725-11 2021 CONCLUSION: The present study proves that AL592284.1 plays an tumor-promotive role in CC via regulating the miR-30a-5p/Vimentin axis, and inhibition of AL592284.1 may pave the way for CC treatment. al592284 42-50 vimentin Homo sapiens 119-127 34804018-10 2021 Sin also inhibited MMP7, MMP9, and vimentin expression in 16HBE cells and respiratory epithelial cells from mice with asthma. sinomenine 0-3 vimentin Homo sapiens 35-43 34772165-0 2021 Kinetics of Zinc Evaporation from Aluminium Alloys Melted Using VIM and ISM Technologies. Aluminum 34-43 vimentin Homo sapiens 64-67 34772165-11 2021 Comparison of ISM and VIM technologies in the removal efficiency of the Al-Zn alloy indicates a higher removal efficiency using the first technology, which, using the same conditions, achieves 80% of the removal efficiency of the component. Aluminum 72-74 vimentin Homo sapiens 22-25 34772165-11 2021 Comparison of ISM and VIM technologies in the removal efficiency of the Al-Zn alloy indicates a higher removal efficiency using the first technology, which, using the same conditions, achieves 80% of the removal efficiency of the component. Zinc 75-77 vimentin Homo sapiens 22-25 34837933-9 2021 In addition, mRNA analyses demonstrated that MOLT4 and jurkat cells, expressed p53 gene more than 10-fold higher compared with untreated cells in three independent experiments while the cells suppressed the expression of a subset of functionally related genes including MYC, BCL2, APEX, SIRT1, SNAIL1 and vimentin to some extent, following 5-AZA treatment. Azacitidine 340-345 vimentin Homo sapiens 305-313 34736391-7 2021 After COM stimulation, the expression levels of the epithelial cell markers E-cadherin and zonula occludens (ZO)-1 in HK-2 cells significantly decreased, whereas the levels of the mesenchymal cell markers N-cadherin, vimentin and alpha-smooth muscle actin (alpha-SMA) significantly increased. Calcium Oxalate 6-9 vimentin Homo sapiens 217-225 34729639-6 2022 RESULTS: Surgically excised premacular tissue of eyes with TMH showed a less pronounced positive immunoreactivity for anti-glutamine synthetase, anti-vimentin and anti-IBA1 compared to eyes with IMH. tmh 59-62 vimentin Homo sapiens 150-158 34332039-0 2021 Isorhapontigenin (ISO) inhibits EMT through FOXO3A/METTL14/VIMENTIN pathway in bladder cancer cells. isorhapontigenin 0-16 vimentin Homo sapiens 59-67 34332039-0 2021 Isorhapontigenin (ISO) inhibits EMT through FOXO3A/METTL14/VIMENTIN pathway in bladder cancer cells. isorhapontigenin 18-21 vimentin Homo sapiens 59-67 34332039-4 2021 We found that ISO inhibited Vimentin, one of the EMT markers, in the invasive bladder cancer cell lines U5637 and T24T. isorhapontigenin 14-17 vimentin Homo sapiens 28-36 34332039-5 2021 ISO reduced Vimentin protein level by increasing the expression of METTL14. isorhapontigenin 0-3 vimentin Homo sapiens 12-20 34697150-7 2021 (6)-Gingerol also inhibited oral cancer cell migration and invasion by up-regulating E-cadherin and down-regulating N-cadherin and vimentin. gingerol 0-12 vimentin Homo sapiens 131-139 34549308-8 2021 In addition, miR-125a-5p downregulated the expression levels of TAFAZZIN, Transglutaminase 2, phosphorylated-AKT, N-cadherin, vimentin and proliferating cell nuclear antigen, and significantly increased those of E-cadherin, cleaved caspase-3 and Bax in MCF7/Adr cells. mir-125a-5p 13-24 vimentin Homo sapiens 126-134 34723978-7 2021 PCR was used for the detection carbapenem-resistant genes (OXA-48, IMP, NDM, VIM, and KPC). Carbapenems 31-41 vimentin Homo sapiens 77-80 34769152-5 2021 We found that KU-32 treatment significantly reduced vimentin bundling in carrier and patient cells. KU-32 14-19 vimentin Homo sapiens 52-60 34986537-6 2021 Resveratrol inhibited the wound healing and invasion of liver cancer cells; increased the expression of E-cadherin, and decreased the expression of vimentin and Twist1. Resveratrol 0-11 vimentin Homo sapiens 148-156 34426261-5 2021 RESULTS: We revealed that, in the non-invasive MCF10DCIS cells but not in the post-EMT MCF7 cells, low oxygen availability induced the decrease of E-cadherin and the increase of vimentin and motility, that were prevented by GE administration. Oxygen 103-109 vimentin Homo sapiens 178-186 34313388-5 2021 Vimentin expression in HUVECs, evaluated using western blot, confirmed superior barrier integrity in the presence of beta-BA. boswellic acid 117-124 vimentin Homo sapiens 0-8 34638417-7 2021 Regorafenib reversed TGF-beta1-induced P-STAT3 and SHP-1 through induction of epithelial mesenchymal marker E-cadherin and downregulation of vimentin protein expression in both co-cultures engrafting healthy and cirrhotic 3D scaffolds. regorafenib 0-11 vimentin Homo sapiens 141-149 34911833-15 2021 Western blotting showed that compared with the control group, the expression levels of MMP-9, MMP-2 and vimentin protein in PC-9 and H1975 cells in 1, 2 and 4 micromol/L almonertinib treatment group were significantly lower, and the expression level of E-cadherin protein was significantly higher (all P<0.05). Almonertinib 170-182 vimentin Homo sapiens 104-112 34712379-8 2021 It showed that the expression of epithelial marker E-cadherin and ZO-1 remarkably augmented with BBR treatment, as well as declined mesenchymal markers, including N-cadherin and Vimentin, decreased transcription factor Snail and Slug. Berberine 97-100 vimentin Homo sapiens 178-186 34765761-10 2021 KSM-66 also modulated oxidative response proteins: peroxiredoxin-I, VGF and vimentin proteins upon 6-OHDA pre/post treatments. Oxidopamine 99-105 vimentin Homo sapiens 76-84 34331954-8 2021 Additionally, we found that vorinostat downregulated the expression of UBE2C, SQSTM1/p62, E-cadherin, N-cadherin, and vimentin in SiHa and HeLa cells. Vorinostat 28-38 vimentin Homo sapiens 118-126 34331954-9 2021 Our results also showed that vorinostat can downregulate the expression of SQSTM1/p62, N-cadherin, and vimentin during the treatment of cervical cancer cells by regulating UBE2C, while upregulating the expression of E-cadherin. Vorinostat 29-39 vimentin Homo sapiens 103-111 34685577-0 2021 Co-Expression of CD34, CD90, OV-6 and Cell-Surface Vimentin Defines Cancer Stem Cells of Hepatoblastoma, Which Are Affected by Hsp90 Inhibitor 17-AAG. tanespimycin 143-149 vimentin Homo sapiens 51-59 34542739-8 2022 MiR-511-5p mimics significantly upregulated E-cadherin and downregulated N-cadherin, Vimentin and Snail, and consequently inhibited cell migration and invasion. mir-511-5p 0-10 vimentin Homo sapiens 85-93 34641401-5 2021 When synergy was observed, for example with curcumin and irinotecan, this was unrelated to MET induction, as assessed by changes in E-cadherin and vimentin expression. Curcumin 44-52 vimentin Homo sapiens 147-155 34641401-5 2021 When synergy was observed, for example with curcumin and irinotecan, this was unrelated to MET induction, as assessed by changes in E-cadherin and vimentin expression. Irinotecan 57-67 vimentin Homo sapiens 147-155 34530574-20 2021 Compared with NC group, overexpression of CacyBP inhibited E-cadherin expression while promoted the expressions of N-cadherin, Snail1, Vimentin and p-Akt, which could be restored by LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 182-190 vimentin Homo sapiens 135-143 34571970-0 2021 Combination Treatment with the Vimentin-Targeting Antibody hzVSF and Tenofovir Suppresses Woodchuck Hepatitis Virus Infection in Woodchucks. Tenofovir 69-78 vimentin Homo sapiens 31-39 34260275-4 2021 Here, we developed three practical agar-based disk-diffusion tests (double-disk synergy test (DDST), disk potentiation test, and modified carbapenem inactivation method (mCIM)) to discriminate the production of subclass B1 MbetaLs, such as IMP-, NDM-, and VIM-type MbetaLs, from the other carbapenemases, especially serine-type carbapenemases. Agar 35-39 vimentin Homo sapiens 256-259 34107056-4 2021 In this study we analyzed the presence of anti-vimentin/cardiolipin (aVim/CL) IgA in a large cohort of patients with SN-APS, evaluating their possible association with clinical manifestations of the syndrome. sn-aps 117-123 vimentin Homo sapiens 47-55 34273686-9 2021 The anti-HCC mechanisms revealed that CAP/GA-sHA-DOX NPs could down-regulate the expression level of Vimentin and P-gp, reverse epithelial-mesenchymal transition (EMT) of tumor cells. Doxorubicin 49-52 vimentin Homo sapiens 101-109 34278471-12 2021 miR-29a-3p administration reversed the SPARC-induced effects on E-cadherin and vimentin expression. mir-29a-3p 0-10 vimentin Homo sapiens 79-87 34577560-8 2021 We further observed that adenine downregulated the protein levels of tissue plasminogen activator, matrix metalloproteinase-9, Snail, TWIST, and vimentin, but upregulated the tissue inhibitor of metalloproteinase-1 expression in DLD-1 cells. Adenine 25-32 vimentin Homo sapiens 145-153 34539879-5 2021 The expression of ZEB1 and vimentin were down-regulated, while the level of E-cadherin was increased after DMY treatment. dihydromyricetin 107-110 vimentin Homo sapiens 27-35 34126197-7 2021 Our conclusions affirmed that pre-incubation with green tea extract (80 mug/ml) and EGCG (60 mumol/L) significantly reversed the impacts of TGF-beta in Hela and SiHa cells by decreasing Vimentin, ZEB, Slug, Snail, and Twist and increasing E-cadherin expression. epigallocatechin gallate 84-88 vimentin Homo sapiens 186-194 34439000-3 2021 We detected carbapenem resistance genes in 11 (84.6%) of 13 samples from patients with BC-documented BSIs (10 caused by KPC-producing Klebsiellapneumoniae and 1 caused by VIM/CMY-producing Citrobacter freundii). Carbapenems 12-22 vimentin Homo sapiens 171-174 34405891-10 2022 Apatinib enhanced apoptosis, diminished migration and invasion of HGC-27R cells, elevated proapoptotic protein expression, and reduced Bcl-2, vimentin, snail, MMP-3, MMP-2, and MMP-9 expressions. apatinib 0-8 vimentin Homo sapiens 142-150 34408164-8 2021 In contrast, AMCs expressed vimentin and formed Cx43 plaques between cells found in the outer edges of the wound. amcs 13-17 vimentin Homo sapiens 28-36 34383763-3 2021 We found that norcycloartocarpin suppressed anchorage-independent growth, cell migration, invasion, filopodia formation, and decreased EMT in a dose-dependent manner at 24 h, which were correlated with reduced protein levels of N-cadherin, Vimentin, Slug, p-FAK, p-Akt, as well as Cdc42. norcycloartocarpin 14-32 vimentin Homo sapiens 240-248 34383767-7 2021 Overexpression of miR-1285 led to upregulation of zonula occludens-1, downregulation of alpha-smooth muscle actin and vimentin, cell migration and cell contractility-all EMT features-in the TGF-beta2-treated ARPE-19 cells. mir-1285 18-26 vimentin Homo sapiens 118-126 34188711-5 2021 Following treatment of GBC cells with melatonin, the protein levels of the epithelial marker, E-cadherin, significantly increased, while the expression levels of the mesenchymal markers, N-cadherin, Snail and vimentin, notably decreased. Melatonin 38-47 vimentin Homo sapiens 209-217 34532441-10 2021 Western blot showed that TP reversed the process of EMT in glioma cells, which was evidenced by the upregulated expression of the epithelial marker E-cadherin, and the downregulated expression of the mesenchymal markers N-cadherin, Vimentin, ZEB1, Snail, and Slug. triptolide 25-27 vimentin Homo sapiens 232-240 34332517-6 2021 RESULTS: Through meta-analysis, this study found that arsenic could promote the phosphorylation of STAT3 (SMD=4.21, 95%CI (1.05, 7.37)), and increase IL-6 and p-JAK2, Vimentin, VEGF expression levels, thereby inducing malignant cell proliferation. Arsenic 54-61 vimentin Homo sapiens 167-175 34062408-4 2021 Here we used a cellular model of mild nitroxidative stress in which a peroxynitrite donor induced transient changes in the organization of three key cytoskeletal proteins, i.e., vimentin, actin and tubulin. Peroxynitrous Acid 70-83 vimentin Homo sapiens 178-186 34062408-6 2021 Using high-resolution mass spectrometry, 62 different PTMs were identified and relatively quantified in vimentin, actin and tubulin, including 12 enzymatic, 13 oxidative and 2 nitric oxide-derived modifications as well as 35 modifications by carbonylated lipid peroxidation products, thus evidencing the occurrence of a chain reaction with formation of numerous reactive species and activation of multiple signaling pathways. Nitric Oxide 176-188 vimentin Homo sapiens 104-112 34062408-9 2021 Moreover, we identified protein PTM "hot spots", such as the single cysteine residue of vimentin, which was detected in seven modified forms, thus, supporting its role in PTM crosstalk and redox sensing. Cysteine 68-76 vimentin Homo sapiens 88-96 34087674-5 2021 In detail, the serine residue of vimentin was phosphorylated at position 38 (Ser38) by calcium calmodulin-dependent protein kinase II gamma (CaMKIIgamma), and vimentin filaments reorganized into cage-like structures enwrapping PRRSV replication complex (RC) at the perinuclear location. Serine 15-21 vimentin Homo sapiens 33-41 34354794-8 2021 Further study showed that GSPs inhibited EMT by reversing the TGF-beta-induced morphological change and upregulation of mesenchymal markers N-cadherin, vimentin, and Slug as well as downregulation of epithelial markers E-cadherin and ZO-1 in 5637 cells. Grape Seed Proanthocyanidins 26-30 vimentin Homo sapiens 152-160 34539818-2 2021 Methods: Three acetylated peptides (ac-lysine, ac-lysine.inv and ac-ornithine) derived from vimentin were employed to measure AAPA by enzyme-linked immunosorbent assay (ELISA) in sera of 120 patients with early RA (eRA), 195 patients with established RA (est RA), 99 healthy controls (HC), and 216 patients with other inflammatory rheumatic diseases. ac-lysine 36-45 vimentin Homo sapiens 92-100 34539818-2 2021 Methods: Three acetylated peptides (ac-lysine, ac-lysine.inv and ac-ornithine) derived from vimentin were employed to measure AAPA by enzyme-linked immunosorbent assay (ELISA) in sera of 120 patients with early RA (eRA), 195 patients with established RA (est RA), 99 healthy controls (HC), and 216 patients with other inflammatory rheumatic diseases. ac-lysine 47-56 vimentin Homo sapiens 92-100 34539818-2 2021 Methods: Three acetylated peptides (ac-lysine, ac-lysine.inv and ac-ornithine) derived from vimentin were employed to measure AAPA by enzyme-linked immunosorbent assay (ELISA) in sera of 120 patients with early RA (eRA), 195 patients with established RA (est RA), 99 healthy controls (HC), and 216 patients with other inflammatory rheumatic diseases. 4-(3-amido-4-phenyl-2-azetidinonyl)-1-phenylacetic acid 126-130 vimentin Homo sapiens 92-100 34290057-4 2021 In response to microbial invasion, resident Vimentin+ stromal cells, connective tissue cells genetically marked by Twist2, are activated during the propagation phase of the disease, but not during initiation and resolution phases, and become a primary source of prostaglandin E2 (PGE2). Dinoprostone 262-278 vimentin Homo sapiens 44-52 34290057-4 2021 In response to microbial invasion, resident Vimentin+ stromal cells, connective tissue cells genetically marked by Twist2, are activated during the propagation phase of the disease, but not during initiation and resolution phases, and become a primary source of prostaglandin E2 (PGE2). Dinoprostone 280-284 vimentin Homo sapiens 44-52 34270886-4 2021 We found that expression of KDM5A and P-glycoprotein (P-gp), which plays a critical role in the development of paclitaxel resistance, were significantly higher in PTX-Calu-3 cells compared to SK-LI-1, Calu-3, and A549 cells.. We observed a significant increase in the expression of mesenchymal markers N-cadherin and vimentin, and a concomitant decrease in expression of E-cadherin and alpha-catenin in PTX-Calu-3 compared to SK-LI-1, Calu-3, and A549 lung cancer cell lines. ptx 163-166 vimentin Homo sapiens 317-325 34170130-6 2021 PCZ treatment in cells induced a morphological transition with E-cadherin decrease and vimentin and Snail increase via the oxidative stress and TGF-beta/Smad pathways. propiconazole 0-3 vimentin Homo sapiens 87-95 34319041-9 2021 RESULTS: MTT assay revealed IC50 of MDA-MB-468 cells at 2 microM for 24 h. Subsequently, DHTS treatment in TNBC cell lines (MDA-MB-468 and MDA-MB-231) led to decrease in mesenchymal markers i.e. vimentin, N-cadherin and, active beta-catenin. dhts 89-93 vimentin Homo sapiens 195-203 34209165-5 2021 Our results demonstrated that datelliptium downregulated the expression of the mesenchymal markers, including N-cadherin, vimentin, slug, snail, and claudin-1. detalliptinium 30-42 vimentin Homo sapiens 122-130 34203497-0 2021 Molecular Insight into the Regulation of Vimentin by Cysteine Modifications and Zinc Binding. Cysteine 53-61 vimentin Homo sapiens 41-49 34203497-2 2021 The vimentin network undergoes marked reorganizations in response to oxidative stress, in which modifications of vimentin single cysteine residue, Cys328, play an important role, and is modulated by zinc availability. Cysteine 129-137 vimentin Homo sapiens 4-12 34203497-2 2021 The vimentin network undergoes marked reorganizations in response to oxidative stress, in which modifications of vimentin single cysteine residue, Cys328, play an important role, and is modulated by zinc availability. Cysteine 129-137 vimentin Homo sapiens 113-121 34203497-6 2021 Vimentin oxidation can induce disulfide crosslinking, implying the close proximity of Cys328 from neighboring dimers in certain vimentin conformations, supported by our computational models. Disulfides 30-39 vimentin Homo sapiens 0-8 34203497-8 2021 Moreover, zinc selectively protects vimentin from crosslinking using short-spacer cysteine-reactive but not amine-reactive agents. Cysteine 82-90 vimentin Homo sapiens 36-44 34203497-12 2021 Moreover, they provide a molecular standpoint for vimentin regulation through the interplay between cysteine modifications and zinc availability. Cysteine 100-108 vimentin Homo sapiens 50-58 34204745-11 2021 Furthermore, the XN-treatment counteracted the PMA-induced EMT of the A549 cells by the upregulation of E-cadherin and alpha-E-catenin and the downregulation of N-cadherin, vimentin, and Snail-1 expression. xanthohumol 17-19 vimentin Homo sapiens 173-181 34204745-11 2021 Furthermore, the XN-treatment counteracted the PMA-induced EMT of the A549 cells by the upregulation of E-cadherin and alpha-E-catenin and the downregulation of N-cadherin, vimentin, and Snail-1 expression. Tetradecanoylphorbol Acetate 47-50 vimentin Homo sapiens 173-181 34096887-5 2021 Calycosin treatment inhibited epithelial-mesenchymal transition (EMT) of breast cancer cells by significantly increasing E-cadherin levels and decreasing N-cadherin, Vimentin, CD147, MMP-2, and MMP-9 levels through downregulation of BATF and TGFbeta1. 7,3'-dihydroxy-4'-methoxyisoflavone 0-9 vimentin Homo sapiens 166-174 34150623-6 2021 Lovastatin inhibited EMT as demonstrated by down-regulation of the protein levels of Vimentin and Twist in MDA-MB-231 CSCs in vitro and vivo and by reversal of TGF-beta1-induced morphological change in MCF10A cells. Lovastatin 0-10 vimentin Homo sapiens 85-93 34199353-13 2021 Meanwhile, momelotinib effectively inhibited the IFNGR-JAK-STAT pathway and reduced the migratory/invasive ability of vHCC cells through down-regulating EMT biomarkers (E-cadherin and vimentin), transcription factor (Slug), and significantly inhibits the DNA damage repair enzyme PARP1. N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide 11-22 vimentin Homo sapiens 184-192 34199634-11 2021 The most significant effects occur at 72 h after 2 mM sevoflurane treatment and consist in increased viability, proliferation and aggressiveness and increased vimentin and HIF expression. Sevoflurane 54-65 vimentin Homo sapiens 159-167 33091333-5 2021 To reveal the molecular function of alectinib and lorlatinib, we explored their effects on the cellular levels of EMT markers: VIM and FN1 and the matrix metalloproteinases MMP-9 and MMP-7. alectinib 36-45 vimentin Homo sapiens 127-130 33091333-5 2021 To reveal the molecular function of alectinib and lorlatinib, we explored their effects on the cellular levels of EMT markers: VIM and FN1 and the matrix metalloproteinases MMP-9 and MMP-7. lorlatinib 50-60 vimentin Homo sapiens 127-130 34227092-10 2021 (3) After transfection of miR-101-mimics, the expression level of Vimentin protein was significantly increased, while the expression level of Vimentin protein was significantly decreased after miR-101-inhibitor transfection. mir-101 26-33 vimentin Homo sapiens 66-74 34227092-10 2021 (3) After transfection of miR-101-mimics, the expression level of Vimentin protein was significantly increased, while the expression level of Vimentin protein was significantly decreased after miR-101-inhibitor transfection. mir-101 26-33 vimentin Homo sapiens 142-150 34227092-10 2021 (3) After transfection of miR-101-mimics, the expression level of Vimentin protein was significantly increased, while the expression level of Vimentin protein was significantly decreased after miR-101-inhibitor transfection. mir-101 193-200 vimentin Homo sapiens 66-74 34227092-10 2021 (3) After transfection of miR-101-mimics, the expression level of Vimentin protein was significantly increased, while the expression level of Vimentin protein was significantly decreased after miR-101-inhibitor transfection. mir-101 193-200 vimentin Homo sapiens 142-150 34063134-10 2021 Moreover, chrysophanol also attenuated the EMT by increasing the expression of E-cadherin and reducing the expression of vimentin. chrysophanic acid 10-22 vimentin Homo sapiens 121-129 32621111-12 2021 Furthermore, treatment with VPA significantly decreased the expression of E-cadherin but increased the Vimentin expression. Valproic Acid 28-31 vimentin Homo sapiens 103-111 34071408-3 2021 We showed that atovaquone induced apoptosis and reduced the survival of several aggressive metastatic TNBC cell lines including metastatic patient-derived cells by reducing the expression of integrin alpha6, integrin beta4, FAK, Src, and Vimentin. Atovaquone 15-25 vimentin Homo sapiens 238-246 34066419-4 2021 We discovered that RAB7A regulates AKT and PAK1, and we demonstrated that increased vimentin phosphorylation at Ser38 (Serine 38), observed upon RAB7A overexpression, is due to AKT activity. Serine 119-125 vimentin Homo sapiens 84-92 34090218-7 2021 PS applied cells showed increased motility in A549 cells as well as lost cell to cell connection in MCF7 and HCT116 cells, and induced expression of VIM, ZEB1 and SNAIL2 mRNA levels. Phosphorus 0-2 vimentin Homo sapiens 149-152 34909649-5 2021 We found that sorafenib upregulated the epithelial marker E-cadherin and downregulated the mesenchymal marker vimentin. Sorafenib 14-23 vimentin Homo sapiens 110-118 35597125-5 2022 miR-4742-5p expression induced the decreases of Zo-1 and E-cadherin expression as well as the increases of vimentin and N-cadherin expression, leading to epithelial-mesenchymal transition (EMT) of cancer cells. mir-4742-5p 0-11 vimentin Homo sapiens 107-115 35381387-6 2022 Vimentin associated with SNAP23, and this association was enhanced by OS or histamine. Histamine 76-85 vimentin Homo sapiens 0-8 35381387-7 2022 Acrylamide, a reagent that disrupts vimentin intermediate filaments, prevented histamine/OS-induced SNAP23 translocation, as well as VWF secretion. Acrylamide 0-10 vimentin Homo sapiens 36-44 35381387-7 2022 Acrylamide, a reagent that disrupts vimentin intermediate filaments, prevented histamine/OS-induced SNAP23 translocation, as well as VWF secretion. Histamine 79-88 vimentin Homo sapiens 36-44 35381387-7 2022 Acrylamide, a reagent that disrupts vimentin intermediate filaments, prevented histamine/OS-induced SNAP23 translocation, as well as VWF secretion. Osmium 89-91 vimentin Homo sapiens 36-44 35381387-8 2022 Immunofluorescence analysis revealed that the polarity of the vimentin intermediate filament network decreased after stimulation with histamine or OS. Histamine 134-143 vimentin Homo sapiens 62-70 35381387-8 2022 Immunofluorescence analysis revealed that the polarity of the vimentin intermediate filament network decreased after stimulation with histamine or OS. Osmium 147-149 vimentin Homo sapiens 62-70 35501464-10 2022 In addition, miR-3622 KO inhibited the epithelial-mesenchymal transition involved in prostate cancer metastasis via upregulation of vimentin. mir-3622 13-21 vimentin Homo sapiens 132-140 35381387-9 2022 In addition, inhibition of protein kinase A (PKA) or G protein coupled receptor 68 (GPR68) eliminated the histamine/OS-induced phosphorylation of vimentin at Ser38 and secretion of VWF. Histamine 106-115 vimentin Homo sapiens 146-154 35601076-7 2022 The protein expression levels of E-cadherin were increased but those of N-cadherin, Vimentin and alpha-SMA decreased after HG and simvastatin treatment, and this was reversed by U46619. Simvastatin 130-141 vimentin Homo sapiens 84-92 35601076-7 2022 The protein expression levels of E-cadherin were increased but those of N-cadherin, Vimentin and alpha-SMA decreased after HG and simvastatin treatment, and this was reversed by U46619. 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid 178-184 vimentin Homo sapiens 84-92 35567907-8 2022 Ultrasound microbubble-mediated miR-503-5p downregulation relative to pure liposome-mediated miR-503-5p downregulation better decreased viability, inhibited migration, invasion and tube formation, enhanced apoptosis, upregulated SALL1, E-cadherin and Cleaved caspase-3, and downregulated miR-503-5p, N-cadherin, Vimentin and Bcl-2 in CRC cells. mir-503-5p 32-42 vimentin Homo sapiens 312-320 35567907-8 2022 Ultrasound microbubble-mediated miR-503-5p downregulation relative to pure liposome-mediated miR-503-5p downregulation better decreased viability, inhibited migration, invasion and tube formation, enhanced apoptosis, upregulated SALL1, E-cadherin and Cleaved caspase-3, and downregulated miR-503-5p, N-cadherin, Vimentin and Bcl-2 in CRC cells. mir-503-5p 93-103 vimentin Homo sapiens 312-320 35609876-8 2022 Participants in FG-VIM quartile 4 showed a 18%, 19%, and 17% higher risk for all-cause dementia, AD, and VD, respectively, than those in quartile 1; this particularly included non-obese patients with a longer duration of diabetes, high FG levels, dyslipidemia, and those taking glucose-lowering medications. Glucose 278-285 vimentin Homo sapiens 19-22 35189245-8 2022 Also, silibinin reversed the epithelial-mesenchymal transition (EMT) mechanism by inducing E-cadherin expression and reducing N-cadherin and vimentin expression, suppressing the levels of regulators related to EMT such as Snail, Slug, and ZEB1 transcription factors, and also decreasing PI3K/AKT, Smad2/3, and beta-catenin intermediate molecules in vitro. Silybin 6-15 vimentin Homo sapiens 141-149 35593896-8 2022 Survival analysis identified novel Vimentin as the positive predictor of short progression free survival (PFS) and short overall survival (OS) in MIBC patients. 4-METHYL-2-PENTANOL 146-150 vimentin Homo sapiens 35-43 35597549-8 2022 Repeated exposures of BPA increased the levels of several mesenchymal markers such as N-cadherin, vimentin, cluster of differentiation 44 (CD44), slug, and alpha-smooth muscle actin (alpha-SMA), whereas reduced the level of E-cadherin drastically. bisphenol A 22-25 vimentin Homo sapiens 98-106 35292248-8 2022 In addition, cinobufotalin significantly suppressed the tumor EMT, as demonstrated by increased E-cadherin expression and decreased N-cadherin and vimentin expression, and inhibited formation and metastasis of lung metastases in vivo. cinobufotalin 13-26 vimentin Homo sapiens 147-155 35521898-7 2022 Functionally, propofol restrained cell viability, cell cycle entrance, cell proliferation, migration, and invasion of LUAD cells, accompanied by promoted E-cadherin and depressed CyclinD1 and Vimentin. Propofol 14-22 vimentin Homo sapiens 192-200 35044086-7 2022 The Src inhibitor PP2 suppressed the growth and migration of HepG2/Vector and Huh7/Vector cells with decreased Vimentin, Snail, and Slug and increased cytokeratin and E-Cadherin expressions, but failed to induce the migration and the EMT markers in HepG2/Si36 and Huh7/Si36 cells. pp2 18-21 vimentin Homo sapiens 111-119 35218764-13 2022 The combination of infigratinib, an FGFR inhibitor, and Gem, interrupted cell growth, migration, and invasion via downregulation of FGFR/AKT/mTOR pathways and the EMT-associated proteins vimentin and slug. infigratinib 19-31 vimentin Homo sapiens 187-195 35379924-8 2022 Meanwhile, 27-hydroxycholesterol induced the secretion of FGF2 and IL-6, which contributed to the expression of snail and vimentin. 27-hydroxycholesterol 11-32 vimentin Homo sapiens 122-130 35379924-11 2022 PPIB inhibition reduced 27-hydroxycholesterol-induced expression of snail and vimentin. 27-hydroxycholesterol 24-45 vimentin Homo sapiens 78-86 35461306-8 2022 Knockdown of seRNA LOC100506178 or hnRNPK markedly repressed MICAL2, Vimentin and Snail expression and upregulated E-cadherin expression. serna 13-18 vimentin Homo sapiens 69-77 35461306-9 2022 Overexpression of seRNA LOC100506178 or hnRNPK markedly increased MICAL2, Vimentin and Snail expression and decreased E-cadherin expression. serna 18-23 vimentin Homo sapiens 74-82 35475399-11 2022 The protein expression levels of vimentin, N-cadherin, beta-catenin, c-Myc, and MMP2 were downregulated, while those of E-cadherin and ZO-1 were upregulated after sufentanil treatment. Sufentanil 163-173 vimentin Homo sapiens 33-41 35448920-18 2022 The protein expression levels of p-Smad2/3, Smad2/3 and Vimentin in KYSE150 and KYSE410 cells in DMY group were lower than those in DMSO group (P<0.05). dihydromyricetin 97-100 vimentin Homo sapiens 56-64 35448920-18 2022 The protein expression levels of p-Smad2/3, Smad2/3 and Vimentin in KYSE150 and KYSE410 cells in DMY group were lower than those in DMSO group (P<0.05). Dimethyl Sulfoxide 132-136 vimentin Homo sapiens 56-64 35449812-8 2022 The effect of 5-FU and ZER on the cell viability was investigated by MTT assay in a dose and time-dependent manner, after that, the expression of vimentin, beta-catenin, and survivin was quantified. Fluorouracil 14-18 vimentin Homo sapiens 146-154 35449812-8 2022 The effect of 5-FU and ZER on the cell viability was investigated by MTT assay in a dose and time-dependent manner, after that, the expression of vimentin, beta-catenin, and survivin was quantified. Cerium 23-26 vimentin Homo sapiens 146-154 35050549-0 2022 1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-beta-Lactamase Inhibitors. 3H-1,2,4-Triazole-3-thione 0-23 vimentin Homo sapiens 78-81 35050549-0 2022 1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-beta-Lactamase Inhibitors. 2-Ethylbenzoic acid 41-60 vimentin Homo sapiens 78-81 35050549-4 2022 In particular, Schiff bases formed between diversely 5-substituted-4-amino compounds and 2-carboxybenzaldehyde were broad-spectrum inhibitors of VIM-type, NDM-1 and IMP-1 MBLs. Schiff Bases 15-27 vimentin Homo sapiens 145-148 35050549-4 2022 In particular, Schiff bases formed between diversely 5-substituted-4-amino compounds and 2-carboxybenzaldehyde were broad-spectrum inhibitors of VIM-type, NDM-1 and IMP-1 MBLs. 5-substituted-4-amino compounds 53-84 vimentin Homo sapiens 145-148 35050549-4 2022 In particular, Schiff bases formed between diversely 5-substituted-4-amino compounds and 2-carboxybenzaldehyde were broad-spectrum inhibitors of VIM-type, NDM-1 and IMP-1 MBLs. 2-Carboxybenzaldehyde 89-110 vimentin Homo sapiens 145-148 35433438-5 2022 Mechanistically, icaritin at 20 muM significantly inhibited the phosphorylation of Akt and mTOR, as well as decreased the expression of vimentin and increased the expression of E-cadherin. icaritin 17-25 vimentin Homo sapiens 136-144 35100428-4 2022 The selectivity of Vimentin for G4 repeats versus individual G4s provides an unprecedented result. Dichlorophen 61-64 vimentin Homo sapiens 19-27 35320951-11 2022 The results of GSEA suggested that vimentin may interact with classical pathways in EC. gsea 15-19 vimentin Homo sapiens 35-43 35223210-10 2022 Further mechanistic investigation demonstrated that NaB induced EMT by increasing the expression of Vimentin and SNAI1, decreasing the expression of membrane-bound E-cadherin, and correspondingly promoting E-cadherin translocation from the membrane to the cytoplasm. nab 52-55 vimentin Homo sapiens 100-108 35269669-5 2022 Furthermore, qRT-PCR revealed that olaparib inhibited the mRNA expression of markers associated with tumorigenesis and EMT, notably Ki67, Vimentin, beta-catenin, MMP2, MMP9, p53, and integrin alpha2 and beta1, while E-Cadherin was upregulated. olaparib 35-43 vimentin Homo sapiens 138-146 35186677-8 2022 Artesunate suppressed the EMT which was induced by TGF-beta2 in ARPE-19 cells through sustaining the expression of vimentin and alpha-SMA through the suppression of PI3K, phospho-PI3K, phospho-Akt and Akt. Artesunate 0-10 vimentin Homo sapiens 115-123 35198094-8 2022 The results showed that H2O2 significantly upregulated the expression of alpha-SMA and vimentin and downregulated the expression of ZO-1 and E-cadherin, while cells pretreated with luteolin showed a reversal. Hydrogen Peroxide 24-28 vimentin Homo sapiens 87-95 35163776-10 2022 Migration and invasion analysis showed that evodiamine has anti-metastatic ability on Hep3B and Huh-7 cells and reduces the level of vimentin, an EMT marker. evodiamine 44-54 vimentin Homo sapiens 133-141 35130539-13 2022 Melatonin decreased the expression of Vimentin and Slug, increased the expression of Numb and E-cadherin in Ishikawa cells. Melatonin 0-9 vimentin Homo sapiens 38-46 35083610-5 2022 We observed that curcumol suppressed invasion and migration in human CRC cells associated with upregulation of epithelial markers E-cadherin and Zonula occludens 1 and downregulation of mesenchymal markers N-cadherin and Vimentin as well as EMT-related transcription factors Snail and Twist. curcumol 17-25 vimentin Homo sapiens 221-229 34747319-6 2022 Also, GA treatment significantly decreased the Bax/Bcl2 protein ratio and the expression of Cyclin D1, CDK2, CDK4, MMP-9, N-cadherin, and vimentin in SW620 and HT29 cells. Glycyrrhizic Acid 6-8 vimentin Homo sapiens 138-146 35300770-2 2022 Methods A549 cells were cultured and treated with different concentrations of puerarin.The inhibition rate (IR) on cell proliferation was detected by CCK-8,and qRT-PCR was performed to detect the mRNA levels of miR-490 and denticleless E3 ubiquitin protein ligase(DTL).Double luciferase reporter assay was employed to identify the targets of miR-490 and DTL based on the establishment of NC mimic group,miR-490 mimic group,NC inhibitor group,and miR-490 inhibitor group.The cells treated by 20 mumol/L puerarin were classified into six groups:DMSO,puerarin,puerarin+NC inhibitor,puerarin+miR-490 inhibitor,puerarin+miR-490 inhibitor+Si-NC,and puerarin+miR-490 inhibitor+Si-DTL.Transwell was used to detect cell migration and invasion.Western blotting was performed to detect the protein levels of epithelial-mesenchymal transition-related markers E-cadherin,N-cadherin,and Vimentin. puerarin 78-86 vimentin Homo sapiens 873-881 35163593-0 2022 Propolin G-Suppressed Epithelial-to-Mesenchymal Transition in Triple-Negative Breast Cancer Cells via Glycogen Synthase Kinase 3beta-Mediated Snail and HDAC6-Regulated Vimentin Degradation. propolin G 0-10 vimentin Homo sapiens 168-176 35163593-10 2022 Down-regulated expression of Snail and vimentin and up-regulated expression of E-cadherin were dose- and time-dependently observed in propolin G-treated MDA-MB-231 cells. propolin G 134-144 vimentin Homo sapiens 39-47 35163593-11 2022 Propolin G inhibited Snail and vimentin expressions via the signaling pathways associated with post-translational modification. propolin G 0-10 vimentin Homo sapiens 31-39 35163593-17 2022 Dissociation of HDAC6/Hsp90 with vimentin leading to increased vimentin acetylation and degradation was perceived in the cells with the addition of propolin G. propolin G 148-158 vimentin Homo sapiens 33-41 35163593-17 2022 Dissociation of HDAC6/Hsp90 with vimentin leading to increased vimentin acetylation and degradation was perceived in the cells with the addition of propolin G. propolin G 148-158 vimentin Homo sapiens 63-71 35163593-19 2022 On the contrary, down-regulated expression of vimentin, cell migration and invasion by propolin G were overturned by HDAC6 overexpression. propolin G 87-97 vimentin Homo sapiens 46-54 35163593-20 2022 Conclusively, restraint cell migration and invasion of TNBC by propolin G were activated by the expression of GSK-3beta-suppressed Snail and the interruption of HDAC6-mediated vimentin protein stability. propolin G 63-73 vimentin Homo sapiens 176-184 35203529-13 2022 By further detecting the roles of zingerone NPs in epithelial-mesenchymal transition (EMT), we observed that zingerone NPs substantially altered the levels of EMT-related markers by decreasing the levels of the mesenchymal markers, N-cadherin and vimentin, rather than the epithelial proteins, ZO-1 and E-cadherin, compared with zingerone. zingerone 109-118 vimentin Homo sapiens 247-255 35163332-4 2022 The results showed that this association was capable of inducing a complete wound healing only after 18 h. Moreover, a treatment of vitamin D3 + silver nanoparticles yielded a small percentage of keratinocytes vimentin-positive, suggesting the possibility that the treatment was responsible for epithelial to mesenchymal transition of the cells, facilitating wound healing repair. vitamin d3 + silver 132-151 vimentin Homo sapiens 210-218 34983531-8 2022 RESULTS: In the present study, CeNP-PEG treatment significantly ameliorated renal fibrosis by increased E-cadherin protein expression, and decreased alpha-SMA, Vimentin and Fibronectin expression both in vitro and in vivo. cenp-peg 31-39 vimentin Homo sapiens 160-168 35165522-8 2022 Moreover in vitro experiments, ER stress induced by tunicamycin (TM) not only significantly increased the expression of GRP78 and CHOP, but also caused the epithelial to myofibroblast transformation (EMT) of renal tubular epithelial cells, evidenced by decreased expression of E-cadherin and increased expression of vimentin, and extracellular matrix (ECM) deposition, evidenced by increased expression of fibronectin (FN). Tunicamycin 52-63 vimentin Homo sapiens 316-324 35096835-9 2021 Furthermore, we found that butyrate augmented the previously described effects of HDAC6 inhibitors on CCA cell proliferation and migration by reducing the expression of CD44, cyclin D1, PCNA, Zeb1, and Vimentin. Butyrates 27-35 vimentin Homo sapiens 202-210 35079373-0 2022 Evaluating the effect of Alantolactone on the expression of N-cadherin and Vimentin genes effective in epithelial-mesenchymal transition (EMT) in breast cancer cell line (MDA-MB-231). alantolactone 25-38 vimentin Homo sapiens 75-83 35079373-9 2022 Results: The expression of Vimentin and N-cadherin decreased significantly at 1 muM alantolactone compared to the control group, p < 0.05. alantolactone 84-97 vimentin Homo sapiens 27-35 35079373-10 2022 Conclusion: Alantolactone affects the expression of Vimentin and N-cadherin through STAT3 signaling pathway and suppresses EMT process, metastasis and cancer invasion. alantolactone 12-25 vimentin Homo sapiens 52-60 35008956-7 2022 In transfected HeLa cells, the mutation G2375R adversely affected the targeting of a desmoplakin C-terminal construct containing all three PRDs to vimentin IFs. g2375r 40-46 vimentin Homo sapiens 147-155 34847839-11 2022 MCU overexpression reversed the inhibitory effects of DHA on MICU1, MICU2, N-cadherin, TGF-beta and Vimentin expression. artenimol 54-57 vimentin Homo sapiens 100-108 35176901-9 2022 In addition, celecoxib potentiated the MLN4924-induced EMT, decreased the expression of N-cadherin and vimentin, and activated the expression of E-cadherin. Celecoxib 13-22 vimentin Homo sapiens 103-111 35176901-9 2022 In addition, celecoxib potentiated the MLN4924-induced EMT, decreased the expression of N-cadherin and vimentin, and activated the expression of E-cadherin. pevonedistat 39-46 vimentin Homo sapiens 103-111 35125706-4 2022 Carbapenem resistance was detected by disk diffusion, modified-Hodge, Carba-NP test, and PCR for bla NDM-1, bla KPC, bla OXA-48, bla VIM, bla IMP genes. Carbapenems 0-10 vimentin Homo sapiens 133-136 35178358-0 2021 Metformin is a Novel Suppressor for Vimentin in Human Gastric Cancer Cell Line. Metformin 0-9 vimentin Homo sapiens 36-44 35178358-3 2021 In this study, AGS gastric cancer cells were treated with metformin and vimentin-specific siRNA (vim-siRNA) for 48 h. The impact of metformin and vim-siRNA on vimentin downregulation in AGS cells were analyzed by quantitative PCR and Western blot. Metformin 58-67 vimentin Homo sapiens 159-167 35178358-3 2021 In this study, AGS gastric cancer cells were treated with metformin and vimentin-specific siRNA (vim-siRNA) for 48 h. The impact of metformin and vim-siRNA on vimentin downregulation in AGS cells were analyzed by quantitative PCR and Western blot. Metformin 132-141 vimentin Homo sapiens 159-167 35178358-5 2021 The results showed that inhibition of vimentin due to metformin was comparable with the vim-siRNA. Metformin 54-63 vimentin Homo sapiens 38-46 35178358-7 2021 Our finding for the first time indicated that metformin can be an alternative to specific siRNA for inhibition of vimentin expression and migration of AGS cell line. Metformin 46-55 vimentin Homo sapiens 114-122 35154537-11 2022 Similar to Rh2-treated cells, the miR-524-5p mimic-expressing cells had increased E-cadherin and reduced vimentin levels compared to the control cells. rh2 11-14 vimentin Homo sapiens 105-113 2685109-1 1989 Cells containing immunoreactive vimentin-type intermediate filaments (IF) were identified in paraffin sections and whole-mount preparations of the gerbil inner ear. Paraffin 93-101 vimentin Homo sapiens 32-40 2599104-1 1989 The administration of hydroxyurea (3 x 10(-4) M) and cytosine arabinoside (10(-7) M) greatly induces the expression of the vimentin gene in human promonocytic leukemia U-937 cells. Hydroxyurea 22-33 vimentin Homo sapiens 123-131 2599104-1 1989 The administration of hydroxyurea (3 x 10(-4) M) and cytosine arabinoside (10(-7) M) greatly induces the expression of the vimentin gene in human promonocytic leukemia U-937 cells. Cytarabine 53-73 vimentin Homo sapiens 123-131 2599104-4 1989 Since hydroxyurea and cytosine arabinoside trigger the phenotypic differentiation of U-937 cells, as demonstrated by the induction of the differentiation-specific CD11b and CD11c antigens, it is concluded that vimentin expression might be implicated in the maturation of these cells. Hydroxyurea 6-17 vimentin Homo sapiens 210-218 2599104-4 1989 Since hydroxyurea and cytosine arabinoside trigger the phenotypic differentiation of U-937 cells, as demonstrated by the induction of the differentiation-specific CD11b and CD11c antigens, it is concluded that vimentin expression might be implicated in the maturation of these cells. Cytarabine 22-42 vimentin Homo sapiens 210-218 2808368-1 1989 Peptidylarginine deiminase (proteinarginine iminohydrolase, EC 3.5.3.15) converted some arginine residues to citrulline residues in soluble vimentin, in a micromolar Ca2+-dependent manner and resulted in the loss of polymerization competence of the intermediate filament protein. Arginine 8-16 vimentin Homo sapiens 140-148 2808358-5 1989 By using [3H]puromycin to specifically label nascent chains, we detect nascent vimentin chains that are bound to the cytoskeleton independently of ribosomes. Tritium 10-12 vimentin Homo sapiens 79-87 2808358-5 1989 By using [3H]puromycin to specifically label nascent chains, we detect nascent vimentin chains that are bound to the cytoskeleton independently of ribosomes. Puromycin 13-22 vimentin Homo sapiens 79-87 2808358-6 1989 The fraction of newly synthesized, full-length vimentin that associates with the cytoskeleton immediately correlates in these cell types with the fraction of nascent vimentin chains that are not released from the cytoskeleton by puromycin, RNase, or 0.6 M NaCl. Sodium Chloride 256-260 vimentin Homo sapiens 47-55 2808368-1 1989 Peptidylarginine deiminase (proteinarginine iminohydrolase, EC 3.5.3.15) converted some arginine residues to citrulline residues in soluble vimentin, in a micromolar Ca2+-dependent manner and resulted in the loss of polymerization competence of the intermediate filament protein. Citrulline 109-119 vimentin Homo sapiens 140-148 2808368-5 1989 High performance liquid chromatography and amino acid analyses of lysine-specific protease-generated fragments from deiminated vimentin (about 8 mol of citrulline/mol of vimentin) showed a differential deimination of three structural domains. Citrulline 152-162 vimentin Homo sapiens 127-135 2769264-3 1989 Exposure to PMA increased the amount of 32P incorporation into several phosphoproteins, including two cytosolic proteins with molecular weights of 30,000 (pI 5.5 and 5.7), an acidic 80,000 molecular weight protein (pI 4.5) present in both the cytosolic and membrane fractions, and two cytoskeletal proteins with molecular weights of 60,000 (pI 5.3) and 55,000 (pI 5.6), identified as vimentin and glial fibrillary acidic protein, respectively. Tetradecanoylphorbol Acetate 12-15 vimentin Homo sapiens 384-392 2769264-3 1989 Exposure to PMA increased the amount of 32P incorporation into several phosphoproteins, including two cytosolic proteins with molecular weights of 30,000 (pI 5.5 and 5.7), an acidic 80,000 molecular weight protein (pI 4.5) present in both the cytosolic and membrane fractions, and two cytoskeletal proteins with molecular weights of 60,000 (pI 5.3) and 55,000 (pI 5.6), identified as vimentin and glial fibrillary acidic protein, respectively. Phosphorus-32 40-43 vimentin Homo sapiens 384-392 2671152-1 1989 We generated a monoclonal antibody (MAb), designated LN-6, directed against human vimentin, which retains its immunoreactivity in B5-fixed, paraffin-embedded tissues. Paraffin 140-148 vimentin Homo sapiens 82-90 2503376-2 1989 The in vitro phosphorylation of vimentin, the intermediate filament protein of mesenchymal cells, by kinases A and C is serine-specific and involves only the N-terminal head domain. Serine 120-126 vimentin Homo sapiens 32-40 2744002-4 1989 Our results show that phorbol ester-treated U937 cells exhibited markedly increased levels of fibronectin and of the cytoskeletal proteins actin, myosin and vimentin including a reorganization of actin and vimentin filaments. Phorbol Esters 22-35 vimentin Homo sapiens 157-165 2475513-6 1989 Vimentin was prominently expressed in cultured prostatic stromal cells and could be identified on silver stained 2D gels, fluorographs, and immunoblots of stroma-derived proteins. Silver 98-104 vimentin Homo sapiens 0-8 2474457-2 1989 Desmin, GFAP, vimentin, peripherin and the lightest neurofilament protein (NF-L) were cleaved into carboxy- and amino-terminal halves by N-chlorosuccinimide at their unique trytophan residue. N-chlorosuccinimide 137-156 vimentin Homo sapiens 14-22 2744002-4 1989 Our results show that phorbol ester-treated U937 cells exhibited markedly increased levels of fibronectin and of the cytoskeletal proteins actin, myosin and vimentin including a reorganization of actin and vimentin filaments. Phorbol Esters 22-35 vimentin Homo sapiens 206-214 2466109-0 1989 Evidence that formation of an intermediate filament-protein complex plays a primary role in aggregation of neurofilaments, glial fibrillary acidic protein (GFAP)-filaments and vimentin-filaments by 2,5-hexanedione. 2,5-hexanedione 198-213 vimentin Homo sapiens 176-184 2472733-2 1989 Antigenicity of CK and vimentin was almost completely destroyed during formalin fixation in normal thyroid and all thyroid lesions except for some cases of papillary and squamous cell carcinoma, although the latter showed negative immunostaining with anti-vimentin antibody. cyanogen chloride 16-18 vimentin Homo sapiens 256-264 2472733-2 1989 Antigenicity of CK and vimentin was almost completely destroyed during formalin fixation in normal thyroid and all thyroid lesions except for some cases of papillary and squamous cell carcinoma, although the latter showed negative immunostaining with anti-vimentin antibody. Formaldehyde 71-79 vimentin Homo sapiens 23-31 2922288-3 1989 A series of Bal 31 deletions of the human vimentin promoter are used to show that a sequence residing at -700 is responsible for the serum, and also TPA inducibility of this gene. Tetradecanoylphorbol Acetate 149-152 vimentin Homo sapiens 42-50 2748452-0 1989 Prognostic significance of vimentin positivity in formalin-fixed renal cell carcinomas. Formaldehyde 50-58 vimentin Homo sapiens 27-35 2922288-6 1989 Further deletions and the use of synthetic oligonucleotides demonstrate that a 24-mer containing two AP-1/jun binding sites confer both serum and TPA inducibility upon the human vimentin gene. Oligonucleotides 43-59 vimentin Homo sapiens 178-186 2922288-6 1989 Further deletions and the use of synthetic oligonucleotides demonstrate that a 24-mer containing two AP-1/jun binding sites confer both serum and TPA inducibility upon the human vimentin gene. Tetradecanoylphorbol Acetate 146-149 vimentin Homo sapiens 178-186 2543828-7 1989 Forskolin, but not PMA stimulated phosphorylation of the major intermediate filament protein, vimentin. Colforsin 0-9 vimentin Homo sapiens 94-102 2524200-4 1989 Thus, vimentin and LCA MAbs are sensitive, specific and reliable complementary diagnostic adjuncts that are useful in the definitive diagnosis of NHLs in alcohol-fixed fine needle aspirates. Alcohols 154-161 vimentin Homo sapiens 6-14 2463329-5 1989 Two synthetic peptides of human vimentin containing the sequence Arg-Leu-Arg reacted with the autoimmune antibodies raised against a streptococcal M protein peptide. Arginine 65-68 vimentin Homo sapiens 32-40 2463329-5 1989 Two synthetic peptides of human vimentin containing the sequence Arg-Leu-Arg reacted with the autoimmune antibodies raised against a streptococcal M protein peptide. Leucine 69-72 vimentin Homo sapiens 32-40 2463329-5 1989 Two synthetic peptides of human vimentin containing the sequence Arg-Leu-Arg reacted with the autoimmune antibodies raised against a streptococcal M protein peptide. Arginine 73-76 vimentin Homo sapiens 32-40 2464893-0 1988 Coexpression of cytokeratins and vimentin in hyaluronic acid-rich tissues. Hyaluronic Acid 45-60 vimentin Homo sapiens 33-41 2477048-5 1989 In patients with progressive disease or with only a partial remission after 4 cycles of CABOPP, therapy was switched to a combination consisting of etoposide, ifosfamide and methotrexate (VIM). Methotrexate 174-186 vimentin Homo sapiens 188-191 2541906-11 1989 The mAbs of the BAM series reacted with vimentin as demonstrated by immunofluorescence staining, showing alterations in the aspect of the filaments under the effect of colchicine. Colchicine 168-178 vimentin Homo sapiens 40-48 2670616-2 1989 The aim of the study was to evaluate the incidence of the reactions for vimentin and desmin in gastric leiomyomas routinely processed in formalin and embedded i paraffin. Formaldehyde 137-145 vimentin Homo sapiens 72-80 3408682-9 1988 The TMC reacted strongly with antibodies (monoclonal or polyclonal) against vimentin, common leucocyte antigen, lysozyme, alpha 1-antichymotrypsin and alpha 1-antitrypsin, but were negative with a variety of other antibodies tested (UCHL1, MB1, Ki-B3, Leu-7, KL1, desmin, S-100 protein, F VIII-related antigen and chromogranin A). tmc 4-7 vimentin Homo sapiens 76-84 3376145-5 1988 In contrast, both acrylamide and 2,5-hexanedione caused a perinuclear redistribution of vimentin filaments with sparing of microtubules. Acrylamide 18-28 vimentin Homo sapiens 88-96 3376145-5 1988 In contrast, both acrylamide and 2,5-hexanedione caused a perinuclear redistribution of vimentin filaments with sparing of microtubules. 2,5-hexanedione 33-48 vimentin Homo sapiens 88-96 3376145-6 1988 Biochemical studies revealed that 2,5-hexanedione treatment resulted in high molecular weight vimentin-immunoreactive species, presumably by cross-linking of proteins. 2,5-hexanedione 34-49 vimentin Homo sapiens 94-102 3376145-7 1988 Selective action of both acrylamide and 2,5-hexanedione on vimentin filaments and the similarity of effects suggest that a common mechanism of damage may occur whereby these compounds act directly on both vimentin and neurofilaments. Acrylamide 25-35 vimentin Homo sapiens 59-67 3376145-7 1988 Selective action of both acrylamide and 2,5-hexanedione on vimentin filaments and the similarity of effects suggest that a common mechanism of damage may occur whereby these compounds act directly on both vimentin and neurofilaments. Acrylamide 25-35 vimentin Homo sapiens 205-213 3376145-7 1988 Selective action of both acrylamide and 2,5-hexanedione on vimentin filaments and the similarity of effects suggest that a common mechanism of damage may occur whereby these compounds act directly on both vimentin and neurofilaments. 2,5-hexanedione 40-55 vimentin Homo sapiens 59-67 3376145-7 1988 Selective action of both acrylamide and 2,5-hexanedione on vimentin filaments and the similarity of effects suggest that a common mechanism of damage may occur whereby these compounds act directly on both vimentin and neurofilaments. 2,5-hexanedione 40-55 vimentin Homo sapiens 205-213 2474382-1 1989 A total of 20 patients with intermediate or high-grade non-Hodgkin"s lymphomas who failed to LNH 84 regimen were treated with a combination of VP 16, ifosfamide and methotrexate (VIM regimen). Methotrexate 165-177 vimentin Homo sapiens 179-182 2670616-2 1989 The aim of the study was to evaluate the incidence of the reactions for vimentin and desmin in gastric leiomyomas routinely processed in formalin and embedded i paraffin. Iodine 5-6 vimentin Homo sapiens 72-80 2670616-2 1989 The aim of the study was to evaluate the incidence of the reactions for vimentin and desmin in gastric leiomyomas routinely processed in formalin and embedded i paraffin. Paraffin 161-169 vimentin Homo sapiens 72-80 2552200-2 1989 Incubation with iodoacetamide or N-ethyl maleimide (10(-6) M, 10(-5) M, and 10(-4) M) caused a marked alteration on the actin and microtubule organization, but had little effect on the structural integrity of the vimentin intermediate filaments. Iodoacetamide 16-29 vimentin Homo sapiens 213-221 2552200-2 1989 Incubation with iodoacetamide or N-ethyl maleimide (10(-6) M, 10(-5) M, and 10(-4) M) caused a marked alteration on the actin and microtubule organization, but had little effect on the structural integrity of the vimentin intermediate filaments. Ethylmaleimide 33-50 vimentin Homo sapiens 213-221 2464860-0 1989 Cytoskeletal effects of acrylamide and 2,5-hexanedione: selective aggregation of vimentin filaments. Acrylamide 24-34 vimentin Homo sapiens 81-89 2464860-0 1989 Cytoskeletal effects of acrylamide and 2,5-hexanedione: selective aggregation of vimentin filaments. 2,5-hexanedione 39-54 vimentin Homo sapiens 81-89 2464860-6 1989 Both acrylamide and 2,5-HD caused aggregation of vimentin filaments in a concentration-dependent fashion; these effects occurred at a lower concentration than alterations in other cytoskeletal filaments. Acrylamide 5-15 vimentin Homo sapiens 49-57 2464860-11 1989 These results suggest that both acrylamide and 2,5-HD cause a primary collapse of vimentin intermediate filaments in cultured cells. Acrylamide 32-42 vimentin Homo sapiens 82-90 2839368-2 1988 Digestion of phosphorylated vimentin with lysine-specific endoprotease and subsequent tryptic peptide mapping indicated that a 12 kDa N-terminal fragment contained all the phosphorylation sites found in the intact molecule. Lysine 42-48 vimentin Homo sapiens 28-36 2839368-2 1988 Digestion of phosphorylated vimentin with lysine-specific endoprotease and subsequent tryptic peptide mapping indicated that a 12 kDa N-terminal fragment contained all the phosphorylation sites found in the intact molecule. Peptides 94-101 vimentin Homo sapiens 28-36 2454690-3 1988 Patients not meeting these criteria were switched to a combination of Etoposide, Ifosfamide, Methotrexate, and Bleomycin (VIM-Bleo). Bleomycin 111-120 vimentin Homo sapiens 122-125 3126643-2 1988 Immunohistochemically, TMCs reacted positively to antisera against vimentin, common leukocyte antigen (CLA), lysozyme, alpha 1-antitrypsin (alpha 1-AT), and alpha 1-antichymotrypsin (alpha 1-ACT) and to a monoclonal antibody (KiB3) that detects preferentially B-lymphocytes. trimethylsilyl chloride 23-27 vimentin Homo sapiens 67-75 2892313-6 1988 Colchicine, which also caused the collapse of vimentin filament organization, did not block the reorganization of vimentin filaments in response to viral infection and viral assembly sites appeared normal. Colchicine 0-10 vimentin Homo sapiens 46-54 3275545-2 1988 The protein kinase inhibitor N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride (H8) caused a partial collapse of vimentin organization but its effect was more difficult to discern, since it also induced a dramatic change in cellular morphology. H-8 dihydrochloride 29-95 vimentin Homo sapiens 130-138 3275545-2 1988 The protein kinase inhibitor N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride (H8) caused a partial collapse of vimentin organization but its effect was more difficult to discern, since it also induced a dramatic change in cellular morphology. N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide 97-99 vimentin Homo sapiens 130-138 2824327-1 1987 To determine the difference between normal and neoplastic myoepithelial cells, we performed immunoperoxidase staining for contractile proteins (actin and myosin) and intermediate filament proteins (vimentin and 55- to 57-kilodalton keratin) on paraffin sections from salivary gland tumors. Paraffin 244-252 vimentin Homo sapiens 198-239 2447102-2 1987 When LP-9 cells are cultured in medium supplemented with vitamin A-depleted serum, they grow with an extreme spindle-shaped morphology and synthesize abundant levels of vimentin, but very little keratin. Vitamin A 57-66 vimentin Homo sapiens 169-177 2448365-4 1987 After withdrawal of nickel from the culture medium, vimentin filaments remained attached to the cell periphery as the cells spread out again, but the cytokeratin filaments remained aggregated in a perinuclear position without reestablishing all peripheral connections. Nickel 20-26 vimentin Homo sapiens 52-60 2447102-3 1987 When retinoic acid is added to the medium at 1 X 10(-8) to 1 X 10(-6) M, keratin synthesis is increased, vimentin synthesis is decreased, and the cells assume an epithelioid morphology. Tretinoin 5-18 vimentin Homo sapiens 105-113 3308759-7 1987 On treatment of corneal fibroblasts with colchicine, the filaments recognized by this antibody were withdrawn from their cytoplasmic array to form a perinuclear cap as also observed for vimentin-containing intermediate filaments. Colchicine 41-51 vimentin Homo sapiens 186-194 3308882-4 1987 Whereas the presence of acidic phospholipids in the lipid vesicles was absolutely essential for efficient vimentin labeling, cholesterol played a synergistic role in this reaction. Phospholipids 31-44 vimentin Homo sapiens 106-114 3308882-6 1987 Furthermore, circular dichroism studies performed on the isolated N terminus of vimentin revealed a significant increase in the alpha-helical content of the polypeptide upon its interaction with vesicles containing negatively charged phospholipids. Phospholipids 234-247 vimentin Homo sapiens 80-88 2443000-6 1987 The antigenicity of vimentin was found to be preserved in all alcohol-fixed specimens and in 63% of formalin-fixed tissues. Alcohols 62-69 vimentin Homo sapiens 20-28 2443000-6 1987 The antigenicity of vimentin was found to be preserved in all alcohol-fixed specimens and in 63% of formalin-fixed tissues. Formaldehyde 100-108 vimentin Homo sapiens 20-28 2454275-3 1987 Vimentin and desmin were detected in the sarcomatous portion of carcinosarcoma, focally in the stromal component of phyllodes tumors and not always in the stromal sarcomas. phyllodes 116-125 vimentin Homo sapiens 0-8 3654756-16 1987 TPA reversibly blocks incorporation of [35S]methionine into myofibrillar alpha-actin, MHC, myosin light chains 1 and 2, the tropomyosins, and troponin C. It does not block the synthesis of beta- or gamma-actins, the nonmyofibrillar MHC or light chains, tubulin, vimentin, desmin, or most household molecules. Tetradecanoylphorbol Acetate 0-3 vimentin Homo sapiens 262-270 2435803-3 1987 Expression of the 15TD3 antigen and vimentin was induced simultaneously in some EBV genome-positive cell lines either by EBV superinfection or by 12-0-tetradecanoyl-1-phorbol-13-acetate (TPA) and n-butyrate treatment. 12-0-tetradecanoyl-1-phorbol-13-acetate 146-185 vimentin Homo sapiens 36-44 2435803-3 1987 Expression of the 15TD3 antigen and vimentin was induced simultaneously in some EBV genome-positive cell lines either by EBV superinfection or by 12-0-tetradecanoyl-1-phorbol-13-acetate (TPA) and n-butyrate treatment. Tetradecanoylphorbol Acetate 187-190 vimentin Homo sapiens 36-44 2435803-3 1987 Expression of the 15TD3 antigen and vimentin was induced simultaneously in some EBV genome-positive cell lines either by EBV superinfection or by 12-0-tetradecanoyl-1-phorbol-13-acetate (TPA) and n-butyrate treatment. Butyrates 196-206 vimentin Homo sapiens 36-44 3332664-5 1987 By treating cells with TPA, intercellular junctions were rapidly disrupted and expression of cytokeratin and desmoplakin was dramatically reduced; however, vimentin expression was not affected. Tetradecanoylphorbol Acetate 23-26 vimentin Homo sapiens 156-164 3581871-3 1987 Epinephrine increases the phosphorylation of both 47 Kd and the intermediate filament protein, vimentin. Epinephrine 0-11 vimentin Homo sapiens 95-103 3343992-1 1988 We reported previously that 2,5-hexanedione (2,5-HD), the neurotoxic metabolite of methyl-n-butylketone (MnBK) and n-hexane, induced aggregation of intermediate filaments of the vimentin type in cultured fibroblasts. 2,5-hexanedione 28-43 vimentin Homo sapiens 178-186 3343992-1 1988 We reported previously that 2,5-hexanedione (2,5-HD), the neurotoxic metabolite of methyl-n-butylketone (MnBK) and n-hexane, induced aggregation of intermediate filaments of the vimentin type in cultured fibroblasts. Methyl n-Butyl Ketone 83-103 vimentin Homo sapiens 178-186 3120401-7 1987 Immunocytological investigations revealed strong reactivity of the TMC to antisera against vimentin, common leucocyte antigen (CLA), alpha 1-antitrypsin (alpha 1-AT) and alpha 1-antichymotrypsin (alpha 1-ACT). tmc 67-70 vimentin Homo sapiens 91-99 3533574-1 1986 The in vivo effect of triethyl lead chloride (TriEL) (10(-6)-10(-8) M) on the organization of non-epithelial intermediate filaments (vimentin and desmin filaments) was studied by indirect immunofluorescence microscopy employing different mammalian cell lines. triethyllead 22-44 vimentin Homo sapiens 133-141 3533574-1 1986 The in vivo effect of triethyl lead chloride (TriEL) (10(-6)-10(-8) M) on the organization of non-epithelial intermediate filaments (vimentin and desmin filaments) was studied by indirect immunofluorescence microscopy employing different mammalian cell lines. triethyllead 46-51 vimentin Homo sapiens 133-141 3515830-3 1986 GFAP and vimentin could also be located to typical coiling perinuclear bundles after vinblastine treatment of the cultures. Vinblastine 85-96 vimentin Homo sapiens 9-17 3467175-7 1986 The expression of the vimentin gene was also increased when HL60 cells were induced to differentiate by phorbol esters; it decreased when differentiation was induced by retinoic acid. Phorbol Esters 104-118 vimentin Homo sapiens 22-30 3467175-7 1986 The expression of the vimentin gene was also increased when HL60 cells were induced to differentiate by phorbol esters; it decreased when differentiation was induced by retinoic acid. Tretinoin 169-182 vimentin Homo sapiens 22-30 3780042-3 1986 The repetitive polynucleotides polyinosinic and polyguanylic acid and their deoxyanalogues, actin and vimentin, were found to have the antigenic epitope. Polynucleotides 15-30 vimentin Homo sapiens 102-110 3780042-3 1986 The repetitive polynucleotides polyinosinic and polyguanylic acid and their deoxyanalogues, actin and vimentin, were found to have the antigenic epitope. polyinosinic and polyguanylic acid 31-65 vimentin Homo sapiens 102-110 3017738-4 1986 This processing of vimentin occurred mainly in dense cell cultures and it could not be induced in sparse cell cultures by inhibiting DNA synthesis with ara C, or by arresting cell growth in medium containing 0.1% serum. Cytarabine 152-157 vimentin Homo sapiens 19-27 3733715-6 1986 Addition of the anti-vimentin antibody to the thrombin-stimulated, phosphorylated lysate immuno-precipitated a single 32P-labeled protein (59 kDa). Phosphorus-32 118-121 vimentin Homo sapiens 21-29 3757060-2 1986 We have reported that 2,5-hexanedione, another agent producing focal accumulation of neurofilaments, induces aggregation of intermediate filaments of the vimentin type in human skin fibroblasts grown in tissue culture. 2,5-hexanedione 22-37 vimentin Homo sapiens 154-162 3569305-2 1987 Employing gel permeation chromatography of the complexes on Sephacryl S-300, cholesterol, cholesteryl fatty acid esters and mono-, di- and triglycerides were found to efficiently associate with vimentin. sephacryl s-300 60-75 vimentin Homo sapiens 194-202 3569305-2 1987 Employing gel permeation chromatography of the complexes on Sephacryl S-300, cholesterol, cholesteryl fatty acid esters and mono-, di- and triglycerides were found to efficiently associate with vimentin. Cholesterol 77-88 vimentin Homo sapiens 194-202 3569305-2 1987 Employing gel permeation chromatography of the complexes on Sephacryl S-300, cholesterol, cholesteryl fatty acid esters and mono-, di- and triglycerides were found to efficiently associate with vimentin. cholesteryl fatty acid esters 90-119 vimentin Homo sapiens 194-202 3569305-2 1987 Employing gel permeation chromatography of the complexes on Sephacryl S-300, cholesterol, cholesteryl fatty acid esters and mono-, di- and triglycerides were found to efficiently associate with vimentin. mono-, di- and triglycerides 124-152 vimentin Homo sapiens 194-202 3569305-5 1987 When cholesterol or 1,2-dioleoyl-glycerol was incorporated into phospholipid vesicles, the affinity of the liposomes for vimentin filaments was considerably increased. Cholesterol 5-16 vimentin Homo sapiens 121-129 3569305-5 1987 When cholesterol or 1,2-dioleoyl-glycerol was incorporated into phospholipid vesicles, the affinity of the liposomes for vimentin filaments was considerably increased. diolein 20-41 vimentin Homo sapiens 121-129 3569305-5 1987 When cholesterol or 1,2-dioleoyl-glycerol was incorporated into phospholipid vesicles, the affinity of the liposomes for vimentin filaments was considerably increased. Phospholipids 64-76 vimentin Homo sapiens 121-129 3758902-0 1986 [Effects of KCl on the distribution of vimentin in cultured cells]. Potassium Chloride 12-15 vimentin Homo sapiens 39-47 2422650-1 1986 Treatment of cultured Hodgkin disease (HD) cells with neuraminidase results in decreased reactivity of monoclonal antibody VIM-D5 with its antigen, the X hapten, a fucosyl-N-acetyllactosamine. fucosyl-N-acetyllactosamine 164-191 vimentin Homo sapiens 123-126 3579878-8 1986 Analysis of the detergent/salt inextractable residue by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulphate and 2-mercaptoethanol shows nuclear histones and vimentin. Salts 26-30 vimentin Homo sapiens 183-191 3579878-8 1986 Analysis of the detergent/salt inextractable residue by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulphate and 2-mercaptoethanol shows nuclear histones and vimentin. polyacrylamide 56-70 vimentin Homo sapiens 183-191 3579878-8 1986 Analysis of the detergent/salt inextractable residue by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulphate and 2-mercaptoethanol shows nuclear histones and vimentin. Sodium Dodecyl Sulfate 110-133 vimentin Homo sapiens 183-191 3579878-8 1986 Analysis of the detergent/salt inextractable residue by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulphate and 2-mercaptoethanol shows nuclear histones and vimentin. Mercaptoethanol 138-155 vimentin Homo sapiens 183-191 3579878-19 1986 The detergent/salt inextractable residue is enriched in nuclear histones and vimentin. Salts 14-18 vimentin Homo sapiens 77-85 3865206-3 1985 The molecular form of this soluble vimentin was determined by sucrose density gradient centrifugation, using vimentin-specific antibodies for subsequent ELISA and immunoblotting analyses. Sucrose 62-69 vimentin Homo sapiens 35-43 3011995-1 1986 Receptor agonists that increase cyclic AMP levels in cultured astroglia have been shown to increase 32P-labeling of the intermediate filament proteins glial fibrillary acidic protein (GFAP) and vimentin in these cells. Cyclic AMP 32-42 vimentin Homo sapiens 194-202 3011995-1 1986 Receptor agonists that increase cyclic AMP levels in cultured astroglia have been shown to increase 32P-labeling of the intermediate filament proteins glial fibrillary acidic protein (GFAP) and vimentin in these cells. Phosphorus-32 100-103 vimentin Homo sapiens 194-202 3011995-3 1986 Time course experiments indicated that 6-8 h were required to reach steady-state 32P-labeling of both GFAP and vimentin. Phosphorus-32 81-84 vimentin Homo sapiens 111-119 3011995-4 1986 Treatment with forskolin (10 microM) after steady-state 32P-labeling increased GFAP and vimentin phosphorylation fourfold and twofold, respectively, and also induced a morphological change from polygonal to process-bearing cells within 20-30 min of drug addition. Colforsin 15-24 vimentin Homo sapiens 88-96 3011995-7 1986 These results suggest that forskolin stimulation of GFAP and vimentin increases net number of phosphates associated with these intermediate filament proteins and that the resulting increase in phosphorylation can be dissociated from morphological changes. Colforsin 27-36 vimentin Homo sapiens 61-69 3011995-7 1986 These results suggest that forskolin stimulation of GFAP and vimentin increases net number of phosphates associated with these intermediate filament proteins and that the resulting increase in phosphorylation can be dissociated from morphological changes. Phosphates 94-104 vimentin Homo sapiens 61-69 3865206-5 1985 The tetrameric coiled-coil nature of the soluble form of vimentin was indicated by the digestion pattern with chymotrypsin and by chemical crosslinking with copper-1,10-phenanthroline and dimethylsuberimidate. copper-1,10-phenanthroline 157-183 vimentin Homo sapiens 57-65 3865206-5 1985 The tetrameric coiled-coil nature of the soluble form of vimentin was indicated by the digestion pattern with chymotrypsin and by chemical crosslinking with copper-1,10-phenanthroline and dimethylsuberimidate. Dimethyl Suberimidate 188-208 vimentin Homo sapiens 57-65 3865206-6 1985 The competence of this soluble vimentin to assemble into IF at higher salt concentrations was demonstrated by electron microscopy. Salts 70-74 vimentin Homo sapiens 31-39 3899428-3 1985 Immunoprecipitation and Western blotting techniques have been used to detect the interaction between human anti-vimentin autoantibodies and the two peptides that resulted from the cleavage of vimentin by N-chlorosuccinimide. N-chlorosuccinimide 204-223 vimentin Homo sapiens 112-120 4019517-4 1985 Phosphorylation of vimentin increased in the presence of beta-adrenergic agonists and could be blocked by the antiglaucoma beta-adrenergic antagonist timolol. Timolol 150-157 vimentin Homo sapiens 19-27 4019517-7 1985 Treatment of these cells in culture with the catecholamine hormone, isoproterenol (1 microM), resulted in a profound reorganization of vimentin filaments. catecholamine hormone 45-66 vimentin Homo sapiens 135-143 4019517-7 1985 Treatment of these cells in culture with the catecholamine hormone, isoproterenol (1 microM), resulted in a profound reorganization of vimentin filaments. Isoproterenol 68-81 vimentin Homo sapiens 135-143 4019517-8 1985 This may be correlated with the enhanced levels of phosphorylated vimentin observed upon increasing cellular cyclic AMP. Cyclic AMP 109-119 vimentin Homo sapiens 66-74 3899428-3 1985 Immunoprecipitation and Western blotting techniques have been used to detect the interaction between human anti-vimentin autoantibodies and the two peptides that resulted from the cleavage of vimentin by N-chlorosuccinimide. N-chlorosuccinimide 204-223 vimentin Homo sapiens 192-200 4040578-1 1985 After dialysis against 10 mM-Tris-acetate (pH 8.5), vimentin that has been purified in the presence of urea is present in the form of tetrameric 2 to 3 nm X 48 nm rods known as protofilaments. -tris-acetate 28-41 vimentin Homo sapiens 52-60 4040578-1 1985 After dialysis against 10 mM-Tris-acetate (pH 8.5), vimentin that has been purified in the presence of urea is present in the form of tetrameric 2 to 3 nm X 48 nm rods known as protofilaments. Urea 103-107 vimentin Homo sapiens 52-60 2418692-2 1985 The two tumors that had alcohol fixed blocks were strongly positive for vimentin, whereas one of the tumors fixed only in formalin showed moderately strong staining and two others showed very weak focal positivity; the remaining tumors were negative. Alcohols 24-31 vimentin Homo sapiens 72-80 6199791-6 1984 Treatment of TC7 cells with demecolcine (10 micrograms/ml, 20 hr) resulted in a drastic rearrangement of the keratin and vimentin filaments. Demecolcine 28-39 vimentin Homo sapiens 121-129 2411559-2 1985 An optimum treatment, 5 mM acrylamide in culture medium for 4 h, resulted in formation of a juxtanuclear aggregate containing both keratin and vimentin intermediate filaments. Acrylamide 27-37 vimentin Homo sapiens 143-151 2411559-4 1985 Cells recovered when acrylamide was washed out of the cultures, and normal keratin and vimentin networks reappeared. Acrylamide 21-31 vimentin Homo sapiens 87-95 3838316-0 1985 Induction of cytoskeletal vimentin and actin gene expression by a tumor-promoting phorbol ester in the human leukemic cell line K562. Phorbol Esters 82-95 vimentin Homo sapiens 26-34 3838316-3 1985 There was approximately a 10-fold induction of vimentin biosynthesis following TPA treatment. Tetradecanoylphorbol Acetate 79-82 vimentin Homo sapiens 47-55 3838316-7 1985 A time course showed that vimentin mRNA activity was detectably elevated as early as 3 h after TPA treatment and reached a maximum by 12 h then the level decreased. Tetradecanoylphorbol Acetate 95-98 vimentin Homo sapiens 26-34 3838316-11 1985 These results are consistent with the induction of vimentin and actin gene transcription by TPA in K562 cells. Tetradecanoylphorbol Acetate 92-95 vimentin Homo sapiens 51-59 3925619-1 1985 An immunohistochemical investigation of vimentin, an intermediate filament, was carried out on formalin fixed paraffin embedded sections of 44 malignant mesotheliomas of the pleura and 24 pulmonary adenocarcinomas, in order to assess its value in differential diagnosis. Formaldehyde 95-103 vimentin Homo sapiens 40-48 3925619-1 1985 An immunohistochemical investigation of vimentin, an intermediate filament, was carried out on formalin fixed paraffin embedded sections of 44 malignant mesotheliomas of the pleura and 24 pulmonary adenocarcinomas, in order to assess its value in differential diagnosis. Paraffin 110-118 vimentin Homo sapiens 40-48 6085562-7 1984 The number of vimentin-positive cells could be increased by retinoic acid treatment of NTera-2 cells or by seeding the 2102Ep cells at low cell density. Tretinoin 60-73 vimentin Homo sapiens 14-22 6204097-5 1984 Treatment of vimentin-negative BLCL and Langer-Giedion LCL with azacytidine led to a transient reexpression of vimentin. dextramycine 32-35 vimentin Homo sapiens 13-21 6204097-5 1984 Treatment of vimentin-negative BLCL and Langer-Giedion LCL with azacytidine led to a transient reexpression of vimentin. dextramycine 32-35 vimentin Homo sapiens 111-119 6204097-5 1984 Treatment of vimentin-negative BLCL and Langer-Giedion LCL with azacytidine led to a transient reexpression of vimentin. Azacitidine 64-75 vimentin Homo sapiens 13-21 6204097-5 1984 Treatment of vimentin-negative BLCL and Langer-Giedion LCL with azacytidine led to a transient reexpression of vimentin. Azacitidine 64-75 vimentin Homo sapiens 111-119 3863149-6 1985 We found that TPA treatment leads to a de novo induction of two cytoskeletal proteins, vimentin and actin. Tetradecanoylphorbol Acetate 14-17 vimentin Homo sapiens 87-95 6199791-7 1984 Likewise, treatment with cytochalasin B (10 micrograms/ml, 1 hr) produced a star-like arrangement of the keratin and vimentin filaments and, in most cases, these codistributed with patches of actin. Cytochalasin B 25-39 vimentin Homo sapiens 117-125 6370447-0 1984 Vimentin filaments in spreading, randomly locomoting, and f-met-leu-phe-treated neutrophils. Phenylalanine 68-71 vimentin Homo sapiens 0-8 6540831-2 1984 Whereas uninduced lines exhibited only a discrete reseau of vimentin, TPA treated cells acquire a very rich vimentin network similar to that of normal monocytes. Tetradecanoylphorbol Acetate 70-73 vimentin Homo sapiens 108-116 6885922-2 1983 Cultivation of cells in monolayer or in a spherical configuration on poly-2-hydroxyethylmethacrylate-coated plates revealed a preferential down regulation of vimentin synthesis during suspension culture. Polyhydroxyethyl Methacrylate 69-100 vimentin Homo sapiens 158-166 6202404-4 1984 Two-dimensional gel electrophoresis of the Triton:high-salt-insoluble proteins of normal lung mesothelium disclosed the presence of vimentin and all but the largest (Mr 55,000) of the four simple epithelial keratins synthesized by mesothelial cells in culture. Salts 55-59 vimentin Homo sapiens 132-140 6196977-5 1983 Immunoblotting of Triton-insoluble cytoskeletal proteins of cultured cells electrophoresed in SDS polyacrylamide gels showed that the antigenic determinant is present in proteins of molecular weight 58,000 which comigrates with vimentin. polyacrylamide 98-112 vimentin Homo sapiens 228-236 6358236-11 1983 The protein is resistant to nonionic detergent extraction, is soluble in high salt and can thus be removed from vimentin filaments, but fragments with vimentin in either low salt or anionic detergent and collapses with vimentin in colchicine-treated cells. Salts 78-82 vimentin Homo sapiens 112-120 6313713-6 1983 This was supported by the observation that arginine inhibits the formation of intermediate filaments from intact vimentin. Arginine 43-51 vimentin Homo sapiens 113-121 6313713-11 1983 Among the degradation products of vimentin produced by the specific, Ca2+-activated proteinase, only those with molecular weights higher than 40 X 10(3) bound to arginine methylester Sepharose 4B. Arginine 162-170 vimentin Homo sapiens 34-42 6313713-11 1983 Among the degradation products of vimentin produced by the specific, Ca2+-activated proteinase, only those with molecular weights higher than 40 X 10(3) bound to arginine methylester Sepharose 4B. Sepharose 183-192 vimentin Homo sapiens 34-42 6413517-0 1983 Polyacrylamide gel electrophoretic screening of mammalian cells cultured in vitro for the presence of the intermediate filament protein vimentin. polyacrylamide 0-14 vimentin Homo sapiens 136-144 6413517-1 1983 A total of 53 different cell lines originating from a variety of mammalian species were cultured in vitro and analysed for the presence of vimentin, employing polyacrylamide gradient slab gel electrophoresis in urea/acetic acid as buffer system. Urea 211-215 vimentin Homo sapiens 139-147 6190674-2 1983 Two-dimensional gel electrophoresis (IEF) analysis of short-term [32P]orthophosphate-labelled intermediate-sized filament proteins (keratins and vimentin) from transformed mitotic amnion cells (AMA), have shown that these proteins are modified coordinately and that the half life of the phosphate is about 13 min for the keratins and 11 min for vimentin. Phosphates 70-84 vimentin Homo sapiens 345-353 6188622-7 1983 RA treatment finally led to the appearance and co-expression of keratin fibrils in many of the vimentin-containing F9 cells. Tretinoin 0-2 vimentin Homo sapiens 95-103 6339255-6 1983 Moreover, the 140 kD gp seemed to copurify with vimentin upon reconstitution of intermediate filaments from urea-solubilized cytoskeletal preparations. Urea 108-112 vimentin Homo sapiens 48-56 6337191-1 1983 Antisera to the intermediate filaments vimentin and desmin react with fixed paraffin embedded tissue. Paraffin 76-84 vimentin Homo sapiens 39-47 6179949-7 1982 Treatment of the cultures with vinblastine sulphate induced coiling of the vimentin filaments in both homo- and heterokaryons, whereas the keratin organization was only slightly affected. Vinblastine 31-51 vimentin Homo sapiens 75-83 6141064-2 1984 HeLa cells were examined by immunofluorescence using anti-vimentin and anti-centrosphere anti-bodies, and by transmission electron microscopy (TEM), after vimentin redistribution induced by the action of nocodazole or taxol. Nocodazole 204-214 vimentin Homo sapiens 155-163 6141064-3 1984 A redistribution of vimentin bundles in the centriolar area was observed after nocodazole treatment, although no direct interaction between centrioles and vimentin filaments could be detected. Nocodazole 79-89 vimentin Homo sapiens 20-28 6141064-4 1984 After taxol treatment, the juxtanuclear accumulation of vimentin filaments and the centrioles were rarely observed in the same area. Paclitaxel 6-11 vimentin Homo sapiens 56-64 6187751-7 1983 Exposure of AMA cells to demecolcine (24 h; 10 micrograms/ml) caused the total collapse of vimentin filaments but, as seen by indirect immunofluorescence, caused only a partial redistribution of the IEF 31 and 46 filaments. Demecolcine 25-36 vimentin Homo sapiens 91-99 6954471-5 1982 Once associated with the lipid bilayer, the vimentin polypeptide resists urea treatment, suggesting that it has become an integral constituent associated with part of the membrane. Urea 73-77 vimentin Homo sapiens 44-52 7199528-7 1982 Both synemin and vimentin remain insoluble along with spectrin and actin, in solutions containing nonionic detergent and high salt. Salts 126-130 vimentin Homo sapiens 17-25 7200412-5 1982 In addition, surface labeling of GM607 and human fibroblasts with 125I demonstrated that substantial amounts of vimentin and actin are exposed at the surface of the attached fibroblasts, but there is little evidence of similar exposure at the surface of the suspension-grown GM607. gm607 33-38 vimentin Homo sapiens 112-120 7200412-5 1982 In addition, surface labeling of GM607 and human fibroblasts with 125I demonstrated that substantial amounts of vimentin and actin are exposed at the surface of the attached fibroblasts, but there is little evidence of similar exposure at the surface of the suspension-grown GM607. gm607 275-280 vimentin Homo sapiens 112-120 7200038-0 1982 Vimentin filaments in cultured endothelial cells form butyrate-sensitive juxtanuclear masses after repeated subculture. Butyrates 54-62 vimentin Homo sapiens 0-8 7199528-8 1982 However, brief exposure of isolated membrane to distilled water releases the synemin and vimentin together in nearly pure form, before the release of significant amounts of spectrin and actin. Water 58-63 vimentin Homo sapiens 89-97 33077306-8 2021 In addition, the expressions of TGFbeta1, p-SMAD2/3, N-cadherin and Vimentin were downregulated in NPA cells after LY-364947 treatment with upregulated E-cadherin, decreased cell proliferation and metastasis, and enhanced cell apoptosis, which was reversed by SIX1 overexpression. Lysine 115-117 vimentin Homo sapiens 68-76 6763694-7 1982 The experimental, reversible disturbance by the use of colchicine leads in macrophages to a transient loss of structural and functional identity with drastic alterations of microtubules and vimentin filaments. Colchicine 55-65 vimentin Homo sapiens 190-198 1177491-2 1975 In an effort to exploit the enhancement in catalytic activity which might be derived through hydrophobic interactions between polymeric catalyst and substrate, 1-methyl-5-vinylimidazole (1-Me-5-VIm), 1-methyl-4-vinylimidazole (1-Me-4-VIm), 1-butyl-5-vinylimidazole (1-Bu-5-VIm), and 1-butyl-4-vinylimidazole (1-Bu-4-VIm) have been synthesized and polymerized. 1H-Imidazole, 5-ethenyl-1-methyl- 160-185 vimentin Homo sapiens 194-197 1177491-5 1975 Poly(1-Me-5-VIm) catalyzes the hydrolysis of S18-88 times faster than does 1,5-DMIm. 1,5-dmim 75-83 vimentin Homo sapiens 12-15 1177491-6 1975 The poly(1-Me-5-VIm)-catalyzed hydrolysis of S18- in ethanol-water was analyzed in terms of a simple Michaelis-Menten type mechanism. [N-(3-{bis[2-(pyridin-2-yl-kappaN)ethyl]amino-kappaN}ethyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide](azido)copper 45-48 vimentin Homo sapiens 16-19 1177491-6 1975 The poly(1-Me-5-VIm)-catalyzed hydrolysis of S18- in ethanol-water was analyzed in terms of a simple Michaelis-Menten type mechanism. Indium 50-52 vimentin Homo sapiens 16-19 1177491-6 1975 The poly(1-Me-5-VIm)-catalyzed hydrolysis of S18- in ethanol-water was analyzed in terms of a simple Michaelis-Menten type mechanism. Ethanol 53-60 vimentin Homo sapiens 16-19 1177491-6 1975 The poly(1-Me-5-VIm)-catalyzed hydrolysis of S18- in ethanol-water was analyzed in terms of a simple Michaelis-Menten type mechanism. Water 61-66 vimentin Homo sapiens 16-19 1177492-1 1975 The water solubility of poly(1-Me-5-VIm) has made it possible to achieve phenomenal rate enhancements and to gain even greater insight into the mechanism of catalysis by polymeric imidazoles. Water 4-9 vimentin Homo sapiens 36-39 1177492-2 1975 The poly(1-Me-5-VIm)-catalyzed hydrolysis of S12- exhibited saturation in excess catalyst nad in excess substrate. NAD 90-93 vimentin Homo sapiens 16-19 1177492-9 1975 The intermediacy of an apolar polymer substrate complex for the poly(1-Me-5-VIm)-catalyzed hydrolysis of S12- in water was given support by studies of the effect of temperature on the rate of hydrolysis. Polymers 30-37 vimentin Homo sapiens 76-79 1177492-9 1975 The intermediacy of an apolar polymer substrate complex for the poly(1-Me-5-VIm)-catalyzed hydrolysis of S12- in water was given support by studies of the effect of temperature on the rate of hydrolysis. Water 113-118 vimentin Homo sapiens 76-79 6263485-3 1981 Only trace amounts of phosphotyrosine were detected in myosin heavy chains, alpha-actinin, filamin, and the intermediate filament protein vimentin. Phosphotyrosine 22-37 vimentin Homo sapiens 138-146 7191425-10 1980 These results suggest that the HeLa and CHO cages include intermediate filaments of the vimentin type. cho 40-43 vimentin Homo sapiens 88-96 33846786-10 2021 In addition, apatinib inhibited the epithelial-mesenchymal transition of Hep3b cells by increasing the expression of the epithelial hallmarks E-cadherin and alpha-catenin and decreased the expression of the mesenchymal hallmarks N-cadherin and vimentin. apatinib 13-21 vimentin Homo sapiens 244-252 33941323-7 2021 DHA also down-regulated the levels of Bcl-2, N-cadherin, and Vimentin, and up-regulated the levels of Bax, C-caspase-3 and E-cadherin in ovarian cancer cells. artenimol 0-3 vimentin Homo sapiens 61-69 33949772-5 2021 Mechanistically, nintedanib inhibited injury-induced mesothelial-to-mesenchymal transition (MMT), as demonstrated by decreased expression of alpha-smooth muscle antigen and vimentin and preserved expression of E-cadherin in the CG-injured peritoneum and cultured human peritoneal mesothelial cells exposed to transforming growth factor-beta1. nintedanib 17-27 vimentin Homo sapiens 173-181 34018092-0 2021 CircRNA VIM silence synergizes with sevoflurane to inhibit immune escape and multiple oncogenic activities of esophageal cancer by simultaneously regulating miR-124/PD-L1 axis. Sevoflurane 36-47 vimentin Homo sapiens 8-11 33992097-11 2021 ID1 expression levels was closely related to E-cadherin and vimentin in both osimertinib-sensitive and resistant cells. osimertinib 77-88 vimentin Homo sapiens 60-68 33831787-1 2021 Hsa_circ_0061395(circBACH1) and SERBP1(SERPINE1 mRNA binding protein 1) have been reported to play a carcinogenic role in HCC.In this study, circBACH1, microRNA(miR)-656-3p, and SERBP1 expression levels with quantitative real-time polymerase chain reaction (qRT-PCR) in HCC tissue specimens and cells.The protein levels of SERBP1, E-Cadherin, vimentin, and N-Cadherin were detected with western blotting.Cell proliferation, migration, invasion, and apoptosis were determined with CCK-8, colony formation, transwell, and flow cytometry assays.The targeting relatio-nship between circBACH1 or SERBP1 and miR-656-3p was verified by dual-lucifer- ase reporter assay.The role of circBACH1 was validated by xenograft assay.CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo. Sincalide 480-485 vimentin Homo sapiens 343-351 33524509-14 2021 CESTG decreased cell migration and invasion which correlated with decreased expression of beta-catenin, vimentin and snail. cestg 0-5 vimentin Homo sapiens 104-112 33152143-5 2021 RESULTS: E2 treatment and co-treatment with LPS as a proxy for infection maintained the metastate of EEC (expression of both cytokeratin and vimentin) and the mesenchymal state of CSC. Estradiol 9-11 vimentin Homo sapiens 141-149 33152143-7 2021 E2 led to persistently elevated levels of vimentin throughout the EEC wound healing process. Estradiol 0-2 vimentin Homo sapiens 42-50 33927214-10 2021 Furthermore, the structure of BMI1 and target interaction of AL were virtually screened using the molecular docking program Autodock Vina; AL decreased the expression of N-cadherin, vimentin, and P62 and increased the expression of LC3B and Beclin-1 in xenograft tumors. alantolactone 61-63 vimentin Homo sapiens 182-190 33740620-7 2021 In addition, reduced expressions of vimentin and Kv3.4 were observed in HeLa cells when treated with AKT blocker, MK2206. MK 2206 114-120 vimentin Homo sapiens 36-44 33927214-10 2021 Furthermore, the structure of BMI1 and target interaction of AL were virtually screened using the molecular docking program Autodock Vina; AL decreased the expression of N-cadherin, vimentin, and P62 and increased the expression of LC3B and Beclin-1 in xenograft tumors. alantolactone 139-141 vimentin Homo sapiens 182-190 33911182-9 2021 Nanaomycin K increased the expression of E-cadherin and inhibited the expression of N-cadherin and vimentin in both cell lines. nanaomycin k 0-12 vimentin Homo sapiens 99-107 33925221-8 2021 Both TGF-beta and E2 induced cellular processes related to EMT, such as morphological changes, actin filament reorganization, and mesenchymal markers (N-cadherin and vimentin) expression. Estradiol 18-20 vimentin Homo sapiens 166-174 33893626-10 2021 Furthermore, E-cadherin protein concentration increased while N-cadherin and Vimentin decreased due to increasing PTX treatments. Paclitaxel 114-117 vimentin Homo sapiens 77-85 33925516-5 2021 A2AR activation by ADO induced AKT phosphorylation and then beta-catenin, Snail, and vimentin expression, and these effects were abolished by A2AR-siRNA transfection. Adenosine 19-22 vimentin Homo sapiens 85-93 34029939-14 2021 H&E and IHC analysis indicated that lung and liver metastasis nodules were reduced, and the protein expression of HIF-1alpha and Vimentin were significantly decreased by i.p injection of matrine. matrine 187-194 vimentin Homo sapiens 129-137 33893396-6 2021 Triptolide treatment concentration-dependently suppressed EMT in NCI-H1299 cells, evidenced by significantly elevated E-cadherin expression and reduced expression of ZEB1, vimentin, and slug. triptolide 0-10 vimentin Homo sapiens 172-180 34056302-6 2021 We found that BIRB796 treatment significantly decreased the formation of the cytoskeleton and thus downregulated the movement ability of the cells, as shown by phalloidin staining and vimentin immunofluorescence staining. doramapimod 14-21 vimentin Homo sapiens 184-192 33891336-10 2021 In addition, the expression of TXNDC5, RhoGDI, and RSU1 increased, while that of Vimentin decreased, in skin explants upon treatment with one of the anti-aging compounds, retinoic acid. Tretinoin 171-184 vimentin Homo sapiens 81-89 33888420-10 2021 CONCLUSION: The procedure of DCT is simple and can differentiate isolates of Enterobacterales with KPC-, NDM-, IMP- and VIM-type carbapenemases rapidly, and the modified DCT can detect isolates with OXA-48-like enzymes rapidly. dct 29-32 vimentin Homo sapiens 120-123 33875936-8 2021 Furthermore, NAM inhibited BEV-induced EMT by downregulating fibronectin, alpha-SMA, and vimentin and upregulating ZO-1, decreased the accumulation of ROS and H2O2, and enhanced TAC in BEV-treated ARPE-19 cells. Niacinamide 13-16 vimentin Homo sapiens 89-97 33677350-5 2021 13c inhibited the protein expression of Slug and the protein and RNA expression of the mesenchymal-related proteins N-cadherin and vimentin. Carbon-13 0-3 vimentin Homo sapiens 131-139 33896831-9 2021 CONCLUSIONS: Our results first revealed that TPM3, EFHD2, KRT19 and vimentin were novel autoantibodies in the ascites of relapsed PTX-resistant GC patients. Paclitaxel 130-133 vimentin Homo sapiens 68-76 33921192-5 2021 Immunofluorescence assays confirmed that resveratrol upregulated E-cadherin expression and downregulated vimentin expression. Resveratrol 41-52 vimentin Homo sapiens 105-113 33921192-6 2021 Western blot assay demonstrated that resveratrol combined with cisplatin significantly reduced the expression of fibronectin, vimentin, P-AKT, P-PI3K, P-JNK, P-ERK, Sma2, and Smad3 induced by TGF-beta1 (p < 0.05), and increased the expression of E-cadherin (p < 0.05), respectively. Resveratrol 37-48 vimentin Homo sapiens 126-134 33921192-6 2021 Western blot assay demonstrated that resveratrol combined with cisplatin significantly reduced the expression of fibronectin, vimentin, P-AKT, P-PI3K, P-JNK, P-ERK, Sma2, and Smad3 induced by TGF-beta1 (p < 0.05), and increased the expression of E-cadherin (p < 0.05), respectively. Cisplatin 63-72 vimentin Homo sapiens 126-134 33835632-7 2021 GM potently inhibited hepatic stellate cells (HSCs) growth and epithelial-mesenchymal transition (EMT) progression, as reflected by the altered expression of proliferative (Ki-67, PCNA, and cleaved caspase-3) and EMT-related (E-cadherin and vimentin) proteins. germacrone 0-2 vimentin Homo sapiens 241-249 33545160-12 2021 Moreover, scratch test and western blotting indicated that miRNA-138-5p inhibits cell motility via targeting MMP2, MMP9 and vimentin but up-regulating E-cadherin. mirna-138-5p 59-71 vimentin Homo sapiens 124-132 32813978-5 2021 A low dose carboplatin treatment upregulated N-cadherin and Vimentin expression and downregulated E-cadherin expression, but this effect was abolished by combining with AgIV. Carboplatin 11-22 vimentin Homo sapiens 60-68 33900350-5 2021 EGCG also significantly counteracted the miR483-3p-induced alteration in the expression of epithelial-mesenchymal transition (EMT) markers, E-cadherin and vimentin, and downregulated the endogenous expression of miR483-3p in HCC cells through an epigenetic mechanism that led to the hypermethylation of the miR483-3p promoter region. epigallocatechin gallate 0-4 vimentin Homo sapiens 155-163 33900350-5 2021 EGCG also significantly counteracted the miR483-3p-induced alteration in the expression of epithelial-mesenchymal transition (EMT) markers, E-cadherin and vimentin, and downregulated the endogenous expression of miR483-3p in HCC cells through an epigenetic mechanism that led to the hypermethylation of the miR483-3p promoter region. mir483-3p 41-50 vimentin Homo sapiens 155-163 33900350-5 2021 EGCG also significantly counteracted the miR483-3p-induced alteration in the expression of epithelial-mesenchymal transition (EMT) markers, E-cadherin and vimentin, and downregulated the endogenous expression of miR483-3p in HCC cells through an epigenetic mechanism that led to the hypermethylation of the miR483-3p promoter region. mir483 41-47 vimentin Homo sapiens 155-163 33900350-5 2021 EGCG also significantly counteracted the miR483-3p-induced alteration in the expression of epithelial-mesenchymal transition (EMT) markers, E-cadherin and vimentin, and downregulated the endogenous expression of miR483-3p in HCC cells through an epigenetic mechanism that led to the hypermethylation of the miR483-3p promoter region. p-Bis(2-chloroethyl)amino-o-methoxyphenylalanine 48-50 vimentin Homo sapiens 155-163 33164274-9 2021 Reduction in the expression of vimentin, beta-catenin, and HOTAIR was detected as the result of metformin treatment, but the snail showed a constant expression. Metformin 96-105 vimentin Homo sapiens 31-39 33251669-4 2021 We found that PA suppressed expression of mesenchymal markers (Fibronectin, Vimentin, and N-cadherin), MMP-9, MMP-2, twist, and snail but stimulated the levels of epithelial markers (E-cadherin and Occludin). protocatechuic acid 14-16 vimentin Homo sapiens 76-84 34056302-8 2021 Consistently, the expressions of MMP-2, Vimentin, CyclinD1, and p-p38 were also decreased after BIRB796 treatment. doramapimod 96-103 vimentin Homo sapiens 40-48 33760381-10 2021 In TPC-1 cells ouabain also inhibited cell migration; increased IL-6/IL-6R expression and IL-6 secretion; and diminished vimentin and SNAIL-1 expression. Ouabain 15-22 vimentin Homo sapiens 121-129 33388549-0 2021 RhoA GTPase phosphorylated at tyrosine 42 by src kinase binds to beta-catenin and contributes transcriptional regulation of vimentin upon Wnt3A. Tyrosine 30-38 vimentin Homo sapiens 124-132 33792166-0 2021 Acrylamide Inhibits Vaccinia Virus Through Vimentin-independent Anti-Viral Granule Formation. Acrylamide 0-10 vimentin Homo sapiens 43-51 33792166-4 2021 The collapse of vimentin filaments, using acrylamide, was found to inhibit VACV infection at the level of genome replication, intermediate- and late- gene expression. Acrylamide 42-52 vimentin Homo sapiens 16-24 33550185-0 2021 SARs of a novel series of s-triazine compounds targeting vimentin to induce methuotic phenotype. Triazines 26-36 vimentin Homo sapiens 57-65 33741416-6 2021 KEY FINDINGS: Notably, glutamine promoted the phenotypic switch of VSMCs towards a synthetic phenotype, as evidenced by significantly decreased expression of contractile markers myosin heavy chain 11 (MYH11) and calponin while increased expression of synthetic markers collagen I and vimentin. Glutamine 23-32 vimentin Homo sapiens 284-292 33550185-5 2021 Molecular docking revealed that V6 can form hydrogen bonds with vimentin at 273R and 276Y in its rod domain. Hydrogen 44-52 vimentin Homo sapiens 64-72 33675608-5 2021 Stachydrine prevented TGF-beta1-induced EMT in HepG2 cells, as proved by the increased expression level of E-cadherin and decreased expression levels of N-cadherin and vimentin. stachydrine 0-11 vimentin Homo sapiens 168-176 33842467-15 2021 Conclusions: VIM positively regulated by NR5A2 affected EMT signaling pathways in metastatic CESC, and naringenin was the inhibitor for the treatment of metastatic CESC via suppressing cancer stemness. naringenin 103-113 vimentin Homo sapiens 13-16 33249185-6 2021 Our study revealed that L-theanine could downregulate MMP9, N-cadherin, Vimentin, Snail and upregulate E-cadherin. theanine 24-34 vimentin Homo sapiens 72-80 33650675-9 2021 In addition, both GW9662 and siPPARgamma significantly reversed the VSP-17-induced downregulation of vimentin expression levels and upregulation of E-cadherin expression levels, implying that the VSP-17-induced inhibition of the EMT process may be dependent on PPARgamma. 2-chloro-5-nitrobenzanilide 18-24 vimentin Homo sapiens 101-109 33529743-12 2021 The result of Western blot analysis showed that the expression of F-actin, alpha-tubulin, beta-tubulin and Vimentin in the cells treated with Ce6-PDT were significantly higher than that in the control group (F = 22.251,8.109, 5.840, 4.685 and 18.754, P < 0.05). ce6 142-145 vimentin Homo sapiens 107-115 33569751-12 2021 Besides, miRNA-143 and cisplatin were demonstrated to cooperatively increase the cell cycle arrest at the sub-G1 and G2-M phases, induce autophagy activation, and via downregulation of vimentin inhibit CaSki cell migration. mirna-143 9-18 vimentin Homo sapiens 185-193 33569751-12 2021 Besides, miRNA-143 and cisplatin were demonstrated to cooperatively increase the cell cycle arrest at the sub-G1 and G2-M phases, induce autophagy activation, and via downregulation of vimentin inhibit CaSki cell migration. Cisplatin 23-32 vimentin Homo sapiens 185-193 33410473-9 2021 Continuous treatment with naltrexone also significantly reduced the expression of epithelial markers (E-cadherin and cytokeratin 19), increased the expression of mesenchymal markers (N-cadherin and vimentin) and EMT-inducing transcription factors (Snail and Slug), and further shifted the morphological phenotype of bladder cancer cells to a mesenchymal phenotype. Naltrexone 26-36 vimentin Homo sapiens 198-206 33188878-8 2021 In addition, calycosin reduced the expression of TGF-beta1, SMAD2/3, SLUG, and vimentin. 7,3'-dihydroxy-4'-methoxyisoflavone 13-22 vimentin Homo sapiens 79-87 33250416-1 2021 We have reported that cytoskeletal proteins such as desmin and vimentin are expressed on the surface of muscle, mesenchymal and cancer cells, and possess N-acetyl-beta-D-glucosamine (beta-GlcNAc) residue-binding properties. Acetylglucosamine 154-181 vimentin Homo sapiens 63-71 33250416-1 2021 We have reported that cytoskeletal proteins such as desmin and vimentin are expressed on the surface of muscle, mesenchymal and cancer cells, and possess N-acetyl-beta-D-glucosamine (beta-GlcNAc) residue-binding properties. beta-glcnac 183-194 vimentin Homo sapiens 63-71 33390776-4 2021 In addition, oridonin increased the expression of E-Cadherin while decreased the expressions of vimentin and twist1 at the mRNA and protein levels in a dose-dependent manner. oridonin 13-21 vimentin Homo sapiens 96-104 33501755-9 2021 Autophagy revulsant rapamycin (RAPA) rescued the inhibitory effect of circ-LRP6 on LC3B, vimentin, and Zeb1. Sirolimus 20-29 vimentin Homo sapiens 89-97 33501755-9 2021 Autophagy revulsant rapamycin (RAPA) rescued the inhibitory effect of circ-LRP6 on LC3B, vimentin, and Zeb1. Sirolimus 31-35 vimentin Homo sapiens 89-97 33438566-13 2021 Moreover, anlotinib downregulated the expression of survivin, cyclin D1, CDK4, caspase-3, Bcl-2, MMP-2, MMP-9, vimentin and N-cadherin, but up-regulated cleaved-caspase-3, Bax and E-cadherin and blocked the activity of the PI3K/AKT in HCT-8/5-FU cells. anlotinib 10-19 vimentin Homo sapiens 111-119 33447082-7 2021 The obtained results were associated with microfilaments and vimentin reorganization induced by the manipulation of FHOD1 together with alkaloids treatment. Alkaloids 136-145 vimentin Homo sapiens 61-69 33401954-10 2022 Vimentin, a mesenchymal stem cell marker stained positively in all three tissues of CC, LD, and CD. (S)-2-((S)-2-Amino-4-methylpentanamido)succinic acid 88-90 vimentin Homo sapiens 0-8 33401954-10 2022 Vimentin, a mesenchymal stem cell marker stained positively in all three tissues of CC, LD, and CD. Cadmium 96-98 vimentin Homo sapiens 0-8 32634664-5 2021 The result shows that supported catalyst-based polyionic liquid (P[Vim]POM/GO) performed high activity and excellent recyclability in extraction-oxidation desulfurization (EODS) due to unique state of polyoxometalate and the support of graphene oxide. polyoxometalate I 201-216 vimentin Homo sapiens 67-70 32634664-5 2021 The result shows that supported catalyst-based polyionic liquid (P[Vim]POM/GO) performed high activity and excellent recyclability in extraction-oxidation desulfurization (EODS) due to unique state of polyoxometalate and the support of graphene oxide. graphene oxide 236-250 vimentin Homo sapiens 67-70 33693593-5 2021 Vitamin D treatment also inhibits p-STAT3, Zeb1 and vimentin by 52%, 75% and 77% respectively, and increases E-cadherin by 87%. Vitamin D 0-9 vimentin Homo sapiens 52-60 33500399-2 2021 In this study, we observed that epithelial colorectal cancer (CRC) cells transiently exposed to 5-fluorouracil (5-FU) (a chemotherapeutic drug for CRC) as well as 5-FU-resistant cells (5-FU-R) develop EMT characters as evidenced by activation of Vimentin and augmented invasive properties. Fluorouracil 112-116 vimentin Homo sapiens 246-254 33500399-2 2021 In this study, we observed that epithelial colorectal cancer (CRC) cells transiently exposed to 5-fluorouracil (5-FU) (a chemotherapeutic drug for CRC) as well as 5-FU-resistant cells (5-FU-R) develop EMT characters as evidenced by activation of Vimentin and augmented invasive properties. Fluorouracil 163-167 vimentin Homo sapiens 246-254 33500399-2 2021 In this study, we observed that epithelial colorectal cancer (CRC) cells transiently exposed to 5-fluorouracil (5-FU) (a chemotherapeutic drug for CRC) as well as 5-FU-resistant cells (5-FU-R) develop EMT characters as evidenced by activation of Vimentin and augmented invasive properties. Fluorouracil 163-167 vimentin Homo sapiens 246-254 33500399-4 2021 Treatment with 4DPG restrains Vimentin phosphorylation (Ser38) in 5-FU-R cells, along with downregulation of mesenchymal markers Twist1 and MMP-2 while augmenting the expression of epithelial markers E-cadherin and TIMP-1. Fluorouracil 66-70 vimentin Homo sapiens 30-38 33500399-6 2021 Mechanistically, SiRNA-mediated silencing of Chk2, as well as treatment with Chk2-specific small-molecule inhibitor (PV1019), divulges that 4DPG represses Vimentin activation in a Chk2-dependent manner. 7-nitro-1H-indole-2-carboxylic acid (4-(1-(guanidinohydrazone)ethyl)phenyl)amide 117-123 vimentin Homo sapiens 155-163 33500399-7 2021 Furthermore, immunoprecipitation analysis unveiled that 4DPG prevents complex formation between Vimentin and p53 resulting in the rescue of p53 and its nuclear localization in aggressive 5-FU-R cells. Fluorouracil 187-191 vimentin Homo sapiens 96-104 32329697-9 2021 Despite having no cytotoxic effects, lupeol also significantly inhibited cell migration in A549 cells with decreased expression of the pErk1/2 protein along with N-cadherin and vimentin genes. lupeol 37-43 vimentin Homo sapiens 177-185 33203591-12 2021 CONCLUSIONS: aCPP shows some distinctive clinical features compared with CPP, such as younger age, larger tumor size, more frequent necrosis and peritumoral edema, blurred borders, slightly low signals on T2WI and isointense signals on DWI, and a higher S-100(+)/Vim(+)/Syn(+) positive rate, which may provide more valuable evidence for differential diagnosis and clinical decisions surrounding aCPP. acpp 13-17 vimentin Homo sapiens 263-266 33254385-8 2021 Cd exposure induced cAMP/PKA-COX2, which mediated cell migration and invasion, and decreased expressions of epithelial-mesenchymal transition (EMT) marker, E-cadherin, but increased expressions of N-cadherin and Vimentin. Cadmium 0-2 vimentin Homo sapiens 212-220 33254385-8 2021 Cd exposure induced cAMP/PKA-COX2, which mediated cell migration and invasion, and decreased expressions of epithelial-mesenchymal transition (EMT) marker, E-cadherin, but increased expressions of N-cadherin and Vimentin. Cyclic AMP 20-24 vimentin Homo sapiens 212-220 33179108-9 2021 Following inhibition of miR-140-5p expression, the proliferation, invasion and migration of HCC cells were promoted, E-cadherin expression was decreased, and the levels of vimentin and N-cadherin were increased. mir-140-5p 24-34 vimentin Homo sapiens 172-180 33367934-7 2021 Western blot analysis was used to investigate the metastasis and epithelial-mesenchymal transition (EMT) induced by parthenolide on the expression levels of MMP2, MMP9, E-cadherin, N-cadherin, vimentin and snail. parthenolide 116-128 vimentin Homo sapiens 193-201 33367934-11 2021 The protein levels of E-cadherin were increased (P<0.05) and N-cadherin, vimentin and snail were decreased (P<0.05) by parthenolide treatment. parthenolide 119-131 vimentin Homo sapiens 73-81 32926756-6 2021 Moreover, reduction in MMP2, Slug, and Vimentin protein levels was observed following 6-gingerol treatment of 786-O and ACHN cells. gingerol 86-96 vimentin Homo sapiens 39-47 33442415-4 2021 The expression of E-cadherin, an EMT epithelial marker, was obviously up-regulated, while the expression of Vimentin and N-cadherin, the EMT mesenchymal markers, was dramatically down-regulated by CyH treatment in NSCLC cells. cytochalasin H 197-200 vimentin Homo sapiens 108-116 33408484-12 2020 In addition, miR-138-5p suppressed cell migration and invasion through inhibiting Vimentin expression, and circGSE1 promoted cell migration and invasion through sponging miR-138-5p and enhancing Vimentin expression. mir-138-5p 13-23 vimentin Homo sapiens 82-90 33389483-7 2021 Sequential administration of RSV and FL118 caused TNBC cells accumulating in the G1 phase, and markedly suppressed the mRNA and protein levels of N-cadherin, beta-catenin, Vimentin, Snail, and Slug, and also significantly downregulated mRNA levels of Fibronectin, Twist1, Twist2, Zeb1, and Zeb2 genes, while enhanced the mRNA and protein levels of E-cadherin genes. Resveratrol 29-32 vimentin Homo sapiens 172-180 33389483-7 2021 Sequential administration of RSV and FL118 caused TNBC cells accumulating in the G1 phase, and markedly suppressed the mRNA and protein levels of N-cadherin, beta-catenin, Vimentin, Snail, and Slug, and also significantly downregulated mRNA levels of Fibronectin, Twist1, Twist2, Zeb1, and Zeb2 genes, while enhanced the mRNA and protein levels of E-cadherin genes. 7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione 37-42 vimentin Homo sapiens 172-180 33747527-11 2021 EGCG treatment also resulted in a significant decrease in Bcl-2, MCL-1, and Vimentin, and an increase in E-cadherin. epigallocatechin gallate 0-4 vimentin Homo sapiens 76-84 33339388-13 2020 Intermediate filaments form clusters under RPM conditions as detected by vimentin staining after 7 d and 14 d. Larger meshes appear in the network in 28-day samples. Sirolimus 43-46 vimentin Homo sapiens 73-81 33291334-2 2020 Resistance to carbapenems mainly occurs via the production of carbapenemases, such as VIM, IMP, NDM, KPC and OXA, among others. Carbapenems 14-25 vimentin Homo sapiens 86-89 33371813-5 2021 In addition, Rg3 suppressed the epithelial-mesenchymal transition (EMT) of HCT15 cells and SW48 cells evidenced by detecting EMT related markers E-cadherin, vimentin, and snail expression. ginsenoside Rg3 13-16 vimentin Homo sapiens 157-165 33352689-8 2020 In addition, we demonstrated that ginsenoside M1 dose-dependently inhibited the colony formation and migration ability of SAS and OEC-M1 cells and reduced the expression of metastasis-related protein vimentin. Ginsenosides 34-45 vimentin Homo sapiens 200-208 32988589-0 2020 Effects of the autophagy modulators d-limonene and chloroquine on vimentin levels in SH-SY5Y cells. Limonene 36-46 vimentin Homo sapiens 66-74 32988589-0 2020 Effects of the autophagy modulators d-limonene and chloroquine on vimentin levels in SH-SY5Y cells. Chloroquine 51-62 vimentin Homo sapiens 66-74 32988589-3 2020 However, d-limonene rapidly reduced vimentin levels, an unexpected effect also induced by the autophagy inhibitor chloroquine (CQ). Limonene 9-19 vimentin Homo sapiens 36-44 32988589-3 2020 However, d-limonene rapidly reduced vimentin levels, an unexpected effect also induced by the autophagy inhibitor chloroquine (CQ). Chloroquine 114-125 vimentin Homo sapiens 36-44 32988589-4 2020 The magnitude of vimentin reduction parallels accumulation of LC3-II caused by a brief incubation with d-limonene or CQ. lc3-ii 62-68 vimentin Homo sapiens 17-25 32988589-4 2020 The magnitude of vimentin reduction parallels accumulation of LC3-II caused by a brief incubation with d-limonene or CQ. Limonene 103-113 vimentin Homo sapiens 17-25 32988589-4 2020 The magnitude of vimentin reduction parallels accumulation of LC3-II caused by a brief incubation with d-limonene or CQ. Chloroquine 117-119 vimentin Homo sapiens 17-25 32988589-5 2020 For longer exposure (48 h), d-limonene does not reduce vimentin, nor it increases LC3-II levels; conversely, a clear reduction of vimentin along with a massive accumulation of LC3-II is evident in cells treated with CQ. Chloroquine 216-218 vimentin Homo sapiens 130-138 32801345-9 2020 CONCLUSIONS: The Galectin-3-beta-catenin-IGFBP3/vimentin signalling cascade was determined as a central mechanism controlling HCC metastasis, providing possible biomarkers for predicating vascular metastasis and sorafenib resistance, as well as potential therapeutic targets for the treatment of HCC patients. Sorafenib 212-221 vimentin Homo sapiens 48-56 32988589-7 2020 Our findings suggest an inverse relationship between vimentin reduction and LC3-II accumulation, whose causal link needs to be examined. lc3-ii 76-82 vimentin Homo sapiens 53-61 32988589-8 2020 Further experiments are needed to dissect the role of vimentin reduction in the mechanisms through which CQ impairs fusion of autophagosome with lysosomes as well as in other effects of this drug. Chloroquine 105-107 vimentin Homo sapiens 54-62 33312374-6 2020 Both WZ4003 and ARK5 inhibition suppressed epithelial-to-mesenchymal transition by reducing the expression of vimentin and increasing E-cadherin expression. WZ4003 5-11 vimentin Homo sapiens 110-118 33173347-12 2020 Ropivacaine treatment upregulated E-cadherin protein expression and repressed the protein expression of Vimentin. Ropivacaine 0-11 vimentin Homo sapiens 104-112 32255262-4 2020 The thiol side-chain of the single vimentin cysteine at position 328 (Cys328) is a direct target of oxidative modifications inside cells. Sulfhydryl Compounds 4-9 vimentin Homo sapiens 35-43 32255262-4 2020 The thiol side-chain of the single vimentin cysteine at position 328 (Cys328) is a direct target of oxidative modifications inside cells. Cysteine 44-52 vimentin Homo sapiens 35-43 32157550-7 2020 By performing qRT-PCR and Western blot analysis, we found Vimentin played a pivotal role in modulating erlotinib resistance. Erlotinib Hydrochloride 103-112 vimentin Homo sapiens 58-66 33124760-3 2020 In addition, DTA-64 reduced collagen deposition, transforming growth factor 1 (TGF-beta1) level in BALF and IgE levels in serum, balanced Th1/Th2/Th17 ratio, and decreased mesenchymal proteins (vimentin and alpha-SMA), as well as weekend matrix metalloproteinases (MMP-2 and MMP-9) and NF-kappaB p65 activity. deoxythymidylyl-3'-5'-deoxyadenylate 13-16 vimentin Homo sapiens 194-202 33174044-6 2020 On the contrary, narasin dose-dependently reversed EMT by increasing the expression of E-cadherin and decreasing the expression of N-cadherin, vimentin, beta-catenin and zinc finger E-box-binding homeobox 1 at the protein and gene expression levels. narasin 17-24 vimentin Homo sapiens 143-151 32271944-1 2020 AIMS: Vimentin citrullination, the calcium (Ca2+ )-dependentpeptidylarginine deiminase (PAD)-mediated conversion of anarginine residue of vimentin to a citrulline residue,has emerged as a pathophysiological outcome ofautoimmune diseases and neurodegeneration. Calcium 35-42 vimentin Homo sapiens 138-146 32271944-1 2020 AIMS: Vimentin citrullination, the calcium (Ca2+ )-dependentpeptidylarginine deiminase (PAD)-mediated conversion of anarginine residue of vimentin to a citrulline residue,has emerged as a pathophysiological outcome ofautoimmune diseases and neurodegeneration. anarginine 116-126 vimentin Homo sapiens 6-14 32271944-1 2020 AIMS: Vimentin citrullination, the calcium (Ca2+ )-dependentpeptidylarginine deiminase (PAD)-mediated conversion of anarginine residue of vimentin to a citrulline residue,has emerged as a pathophysiological outcome ofautoimmune diseases and neurodegeneration. anarginine 116-126 vimentin Homo sapiens 138-146 32271944-1 2020 AIMS: Vimentin citrullination, the calcium (Ca2+ )-dependentpeptidylarginine deiminase (PAD)-mediated conversion of anarginine residue of vimentin to a citrulline residue,has emerged as a pathophysiological outcome ofautoimmune diseases and neurodegeneration. Citrulline 152-162 vimentin Homo sapiens 138-146 33014164-8 2020 In addition, miR-1301-3p inhibition upregulated E-cadherin, an epithelial cell maker, and downregulated vimentin, a mesenchymal cell marker. mir-1301 13-21 vimentin Homo sapiens 104-112 33014164-8 2020 In addition, miR-1301-3p inhibition upregulated E-cadherin, an epithelial cell maker, and downregulated vimentin, a mesenchymal cell marker. p-Bis(2-chloroethyl)amino-o-methoxyphenylalanine 22-24 vimentin Homo sapiens 104-112 31854220-5 2020 The expression of MAPK, NF-kappaB, MMP9, MMP2 and vimentin were confirmed by RT-PCR, immunohistochemistry or western blotting.Results: Administration of curcumin significantly inhibited tumour growth, as the tumour weight decreased from 0.67 g (control) to 0.47 g (15 mg/kg) and 0.35 g (30 mg/kg). Curcumin 153-161 vimentin Homo sapiens 50-58 31854220-9 2020 Curcumin also suppressed the level of vimentin.Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target. Curcumin 0-8 vimentin Homo sapiens 38-46 31854220-9 2020 Curcumin also suppressed the level of vimentin.Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target. Curcumin 103-111 vimentin Homo sapiens 38-46 31854220-9 2020 Curcumin also suppressed the level of vimentin.Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target. Curcumin 217-225 vimentin Homo sapiens 38-46 32992303-0 2020 The vimentin cytoskeleton: When polymer physics meets cell biology. Polymers 32-39 vimentin Homo sapiens 4-12 33146702-8 2020 PTEN overexpression promoted apoptosis, inhibited cell migration and invasion, down-regulated the expression of MMP-2 and vimentin, and up-regulated E-cadherin expression, however, these effects could be partially reversed by miR-19b-3p. mir-19b-3p 226-236 vimentin Homo sapiens 122-130 33243974-0 2020 Identification of miR-515-3p and its targets, vimentin and MMP3, as a key regulatory mechanism in esophageal cancer metastasis: functional and clinical significance. mir-515-3p 18-28 vimentin Homo sapiens 46-54 33330466-12 2020 Knocking down the expression of P2 x 7 receptor could significantly inhibit the increase in the expression of N-cadherin, Vimentin, Zeb1, and Snail induced by ATP. Adenosine Triphosphate 159-162 vimentin Homo sapiens 122-130 33000203-11 2020 Upregulation of miR-125a-5p expression inhibited cell viability, migration, invasion and colony formation of SK-Hep1 cells and reduced the expression of HAX1, VEGF, N-cadherin and vimentin, but increased cell apoptosis and the expression of p53 and E-cadherin. mir-125a-5p 16-27 vimentin Homo sapiens 180-188 33023995-8 2020 Inhibition of Wnt signaling via ICG-001 resulted in significantly decreased nasal polypoid lesions (p<0.001), EMT-related markers (p=0.019 for E-cadherin and p=0.002 for vimentin) and the mRNA levels of IL-4 (p<0.001) and IL-17A (p=0.004) compared with the positive control group. Indocyanine Green 32-35 vimentin Homo sapiens 170-178 32855235-0 2020 Artemisinins target the intermediate filament protein vimentin for human cytomegalovirus inhibition. Artemisinins 0-12 vimentin Homo sapiens 54-62 32855235-2 2020 Using a biotin-labeled artemisinin we identified the intermediate filament protein vimentin as an artemisinin target, validated by detailed biochemical and biological assays. Biotin 8-14 vimentin Homo sapiens 83-91 32855235-2 2020 Using a biotin-labeled artemisinin we identified the intermediate filament protein vimentin as an artemisinin target, validated by detailed biochemical and biological assays. artemisinin 23-34 vimentin Homo sapiens 83-91 32855235-2 2020 Using a biotin-labeled artemisinin we identified the intermediate filament protein vimentin as an artemisinin target, validated by detailed biochemical and biological assays. artemisinin 98-109 vimentin Homo sapiens 83-91 32855235-8 2020 Binding of artesunate, an artemisinin monomer, to vimentin prevents virus-induced vimentin degradation, decreasing vimentin phosphorylation at Ser55 and Ser83 and resisting calpain digestion. Artesunate 11-21 vimentin Homo sapiens 50-58 32855235-8 2020 Binding of artesunate, an artemisinin monomer, to vimentin prevents virus-induced vimentin degradation, decreasing vimentin phosphorylation at Ser55 and Ser83 and resisting calpain digestion. Artesunate 11-21 vimentin Homo sapiens 82-90 32855235-8 2020 Binding of artesunate, an artemisinin monomer, to vimentin prevents virus-induced vimentin degradation, decreasing vimentin phosphorylation at Ser55 and Ser83 and resisting calpain digestion. Artesunate 11-21 vimentin Homo sapiens 82-90 32855235-8 2020 Binding of artesunate, an artemisinin monomer, to vimentin prevents virus-induced vimentin degradation, decreasing vimentin phosphorylation at Ser55 and Ser83 and resisting calpain digestion. artemisinin 26-37 vimentin Homo sapiens 50-58 32855235-8 2020 Binding of artesunate, an artemisinin monomer, to vimentin prevents virus-induced vimentin degradation, decreasing vimentin phosphorylation at Ser55 and Ser83 and resisting calpain digestion. artemisinin 26-37 vimentin Homo sapiens 82-90 32855235-8 2020 Binding of artesunate, an artemisinin monomer, to vimentin prevents virus-induced vimentin degradation, decreasing vimentin phosphorylation at Ser55 and Ser83 and resisting calpain digestion. artemisinin 26-37 vimentin Homo sapiens 82-90 32855235-9 2020 In vimentin-deficient fibroblasts, the anti-HCMV activity of artesunate is reduced compared to controls. Artesunate 61-71 vimentin Homo sapiens 3-11 32855235-11 2020 Artesunate binding to vimentin early during infection stabilizes it and antagonizes subsequent HCMV-mediated vimentin destabilization, thus suppressing HCMV replication. Artesunate 0-10 vimentin Homo sapiens 22-30 32855235-11 2020 Artesunate binding to vimentin early during infection stabilizes it and antagonizes subsequent HCMV-mediated vimentin destabilization, thus suppressing HCMV replication. Artesunate 0-10 vimentin Homo sapiens 109-117 33045871-10 2021 Besides, BBR inhibited EMT in cells by decreasing the expressions of MMP-9, N-cadherin and Vimentin and increasing E-cadherin expression. Berberine 9-12 vimentin Homo sapiens 91-99 32817335-7 2020 These results have profound implications for the study of this key GTPase in cancer, particularly because a large number of cancer cell lines with characteristic mesenchymal features show simultaneous up-regulation of vimentin and high basal Rac1-GTP levels when measured biochemically. Guanosine Triphosphate 67-70 vimentin Homo sapiens 218-226 33046716-4 2020 Interestingly, similar to activated AKT in LAD cells, although unable to induce epithelial-mesenchymal transition (EMT), VAL exerts potent pro-invasive and pro-metastatic effects through directly binding to Vimentin and competitively abrogating Trim16-depedent Vimentin polyubiquitination and degradation. Valine 121-124 vimentin Homo sapiens 207-215 33046716-4 2020 Interestingly, similar to activated AKT in LAD cells, although unable to induce epithelial-mesenchymal transition (EMT), VAL exerts potent pro-invasive and pro-metastatic effects through directly binding to Vimentin and competitively abrogating Trim16-depedent Vimentin polyubiquitination and degradation. Valine 121-124 vimentin Homo sapiens 261-269 33050187-7 2020 We indicated an increase in the cellular expression of two astrogliosis markers: glial fibrillary acidic protein and vimentin in cobalamin-deficient NHA using Western blot analysis and immunocytochemistry with confocal laser scanning microscopy. Vitamin B 12 129-138 vimentin Homo sapiens 117-125 33050187-7 2020 We indicated an increase in the cellular expression of two astrogliosis markers: glial fibrillary acidic protein and vimentin in cobalamin-deficient NHA using Western blot analysis and immunocytochemistry with confocal laser scanning microscopy. nha 149-152 vimentin Homo sapiens 117-125 32572729-6 2020 MEK inhibitor PD98059 downregulated the expression of vimentin, matrix metalloproteinase-2/9 (MMP-2/9), and fascin through the inhibition of Erk1/2 activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 14-21 vimentin Homo sapiens 54-62 32679125-8 2020 Pretreatment with ALA mimicked Twist1 siRNA, increased the protein expression of epithelial markers such as E-cadherin, and decreased the protein expression of mesenchymal markers including Twist1, Snail2, N-cadherin, vimentin, and fibronectin. alpha-Linolenic Acid 18-21 vimentin Homo sapiens 218-226 33165335-6 2020 Co-incubation of normal human fibroblast cells (BJ cells) with MKN-45-conditioned medium resulted in overexpression of biomarkers of CAFs, such as FAP, alpha-SMA, MMP, GAL-1, PDGFRbeta, and VIM. mkn-45 63-69 vimentin Homo sapiens 190-193 32420661-6 2020 In addition, mangiferin reversed the LPS-induced downregulation of E-cadherin (epithelial marker); conversely, it significantly inhibited the expression of raised vimentin (mesenchymal markers). mangiferin 13-23 vimentin Homo sapiens 163-171 32855684-10 2020 LiCl treatment prompted beta-catenin-mediated expression of target proteins such as Snail and vimentin in LNCaP/shCD147 cells, and prevented E-cadherin expression, a molecule downstream to Snail. Lithium Chloride 0-4 vimentin Homo sapiens 94-102 32831913-6 2020 DHA treatment also significantly reversed epithelial-mesenchymal transition (EMT) by downregulating the EMT-associated markers, N-cadherin and vimentin, and upregulating the expression of E-cadherin. artenimol 0-3 vimentin Homo sapiens 143-151 32982310-11 2020 Results: GLN suppressed GBM cell growth, migration, and invasion, and also downregulated the expression of Skp2 and mesenchymal markers (Zeb1, N-cadherin, snail, vimentin) in vitro. galangin 9-12 vimentin Homo sapiens 162-170 32758717-10 2020 At the molecular level, decreases in E-cadherin levels and increases in N-cadherin, Vimentin, and beta-catenin levels that were induced by miR-135a-5p overexpression were attenuated by beta-TrCP overexpression. mir-135a-5p 139-150 vimentin Homo sapiens 84-92 32982173-8 2020 Besides that, the expression of keratin was up-regulated while the expression of vimentin, beta-catenin and slug were all down-regulated by emodin in a dose- and time-dependent manner. Emodin 140-146 vimentin Homo sapiens 81-89 32893845-11 2020 The expression levels of N-cadherin, Vimentin, Wnt3a, Snail1, and Twist, as well as the nuclear translocation levels of ss-catenin, were reduced in a curcumin concentration-dependent manner. Curcumin 150-158 vimentin Homo sapiens 37-45 32898628-10 2020 AAI exposure also induced EMT in HCC cells through E-cadherin downregulation and Snail, N-cadherin, and vimentin upregulation. aai 0-3 vimentin Homo sapiens 104-112 32897971-1 2021 Epitope H contains an O-linked N-acetylglucosamine (O-GlcNAcH) residue in a specific conformation and/or environment recognized by the mouse monoclonal antibody H. O-GlcNAcH is present in several types of cells and in several polypeptides, including cytokeratin 8 and vimentin, on the latter in cells under stress. Acetylglucosamine 31-50 vimentin Homo sapiens 268-276 32897971-1 2021 Epitope H contains an O-linked N-acetylglucosamine (O-GlcNAcH) residue in a specific conformation and/or environment recognized by the mouse monoclonal antibody H. O-GlcNAcH is present in several types of cells and in several polypeptides, including cytokeratin 8 and vimentin, on the latter in cells under stress. o-glcnach 52-61 vimentin Homo sapiens 268-276 32897971-1 2021 Epitope H contains an O-linked N-acetylglucosamine (O-GlcNAcH) residue in a specific conformation and/or environment recognized by the mouse monoclonal antibody H. O-GlcNAcH is present in several types of cells and in several polypeptides, including cytokeratin 8 and vimentin, on the latter in cells under stress. o-glcnach 164-173 vimentin Homo sapiens 268-276 32878787-12 2020 We further found that ephemeranthol A exerts its antimetastatic effects via inhibition of EMT, as indicated by the markedly decrease of N-cadherin, vimentin, and Slug. ephemeranthol A 22-37 vimentin Homo sapiens 148-156 33062605-9 2020 Our study found that alpha mangostin treatment increased the expressions of vimentin (P <0.001 versus control). mangostin 21-36 vimentin Homo sapiens 76-84 32480094-10 2020 Increasing CS concentration promoted upregulated vimentin expression in PC-3 cultures and N-cadherin and MMP-2 expression in 22Rv1 cultures. Chondroitin Sulfates 11-13 vimentin Homo sapiens 49-57 32389644-4 2020 After cell binding to fibronectin, there was a time-dependent increase of phosphorylation of serine 39, 56 and 72 in vimentin, which was associated with vimentin filament assembly. Serine 93-99 vimentin Homo sapiens 117-125 32389644-4 2020 After cell binding to fibronectin, there was a time-dependent increase of phosphorylation of serine 39, 56 and 72 in vimentin, which was associated with vimentin filament assembly. Serine 93-99 vimentin Homo sapiens 153-161 32389644-8 2020 Compared with wild type, FLNA KD cells showed loss of phosphorylation of serine 56 and 72 in vimentin and reduced numbers and lengths of cell extensions by >4-fold. Serine 73-79 vimentin Homo sapiens 93-101 32441858-5 2020 Western blot analysis showed that arecoline treatment caused a dose-dependent decrease in E-cadherin expression and dose-dependent increases in N-cadherin, vimentin, alpha-SMA, and collagen expression; reverse transcriptase-polymerase chain reaction analysis revealed dose-dependent increases in alpha-SMA and collagen mRNA. Arecoline 34-43 vimentin Homo sapiens 156-164 32825553-5 2020 We evaluated EMT markers expression by RT-qPCR, Western blot, and immunofluorescence.We found that E2 upregulated the expression of the mesenchymal markers, vimentin, and N-cadherin. Estradiol 99-101 vimentin Homo sapiens 157-165 32066935-6 2020 Vimentin p.(Leu387Pro) expression diminished the amount of peripilin and reduced lipid accumulation in differentiating adipocytes, recapitulating key patient"s features in vivo and in vitro. peripilin 59-68 vimentin Homo sapiens 0-8 32964964-14 2020 Furthermore, miR-5590-3p inhibitors could eliminate the FGD5-AS1 siRNA-induced upregulation of E-cadherin and downregulation of vimentin. mir-5590 13-21 vimentin Homo sapiens 128-136 32711378-3 2020 The type III IFs, vimentin, desmin, peripherin and glial fibrillary acidic protein (GFAP), are targets for diverse modifications by oxidants and electrophiles, for which their conserved cysteine residue emerges as a hot spot. Cysteine 186-194 vimentin Homo sapiens 18-26 32711378-5 2020 We previously proposed that cysteine residues of vimentin and GFAP act as sensors for oxidative and electrophilic stress, and as hinges influencing filament assembly. Cysteine 28-36 vimentin Homo sapiens 49-57 32904674-16 2020 WB detection showed that Carboplatin + LncRNA XIST intervention group could more significantly inhibit beta-catenin, cyclin B1, cyclin D1, N-cadherin, vimentin, Snail protein, and promote the up-regulation of Bax, Caspase-3, E-Cadherin and ZO-1 expression. Carboplatin 25-36 vimentin Homo sapiens 151-159 32413665-4 2020 Endosulfan induced alterations of EMT biomarkers, reflecting repression of E-cadherin expression and induction of fibronectin, snail2, ZEB2, Twist1 and Vimentin. Endosulfan 0-10 vimentin Homo sapiens 152-160 32473523-8 2020 The molecular mechanisms of vinorelbine suppressing the metastatic phenotypes of cancer cells through modulation of E-cadherin, N-cadherin, vimentin and transcription factors Snail, MMP-2 and MMP-9. Vinorelbine 28-39 vimentin Homo sapiens 140-148 32779484-3 2021 Meanwhile, 2-hydroxy-6-tridecylbenzoic acid inhibited cells migration and invasion as well as EMT with the increase of E-cadherin expression accompanied by the decrease of N-cadherin, Vimentin, Snail, MMP-2 and MMP-9 expression. 6-n-tridecylsalicylic acid 11-43 vimentin Homo sapiens 184-192 32493819-5 2020 Alanine scanning mutagenesis indicated that amino acid residues 15-21 at the N-terminal region of the FMDV 3A are responsible for the interaction between 3A and vimentin. Alanine 0-7 vimentin Homo sapiens 161-169 32842595-3 2020 Studies on HepG2 cells (human HCC) demonstrated C60 fullerene ability to inhibit cell growth (IC50 = 108.2 mumol), to induce apoptosis, to downregulate glucose-6-phosphate dehydrogenase, to upregulate vimentin and p53 expression and to alter HepG2 redox state. Fullerenes 52-61 vimentin Homo sapiens 201-209 32731636-7 2020 MRA administration blunted NDF-induced cardiac expression of vimentin and the profibrotic molecules galectin-3/cardiotrophin-1. Norfenfluramine 27-30 vimentin Homo sapiens 61-69 32659284-5 2020 In vivo, p66Shc silencing prevented carbon tetrachloride (CCl4)-induced EMT as evidenced by the upregulation of E-cadherin, downregulation of Vimentin and N-cadherin, and inhibition of oxidative stress and extracellular matrix (ECM) components. Carbon Tetrachloride 36-56 vimentin Homo sapiens 142-150 32659284-5 2020 In vivo, p66Shc silencing prevented carbon tetrachloride (CCl4)-induced EMT as evidenced by the upregulation of E-cadherin, downregulation of Vimentin and N-cadherin, and inhibition of oxidative stress and extracellular matrix (ECM) components. Carbon Tetrachloride 58-62 vimentin Homo sapiens 142-150 32771050-9 2020 In particular, the high levels of vimentin were blunted at increasing doses of cisplatin in condition of DUSP6 over-expression while N-Cadherin contextually increased. Cisplatin 79-88 vimentin Homo sapiens 34-42 32439259-5 2020 In addition, ascofuranone upregulated E-cadherin, and downregulated fibronectin, vimentin, Slug, Snail, and Twist. ascofuranone 13-25 vimentin Homo sapiens 81-89 32439259-6 2020 Inhibition of ERK/AKT/mTOR promoted EGF-induced E-cadherin downregulation and inhibited EGF-induced vimentin upregulation in response to ascofuranone, implying that inhibition of the EGF-induced EMT by ascofuranone was mediated by the ERK and AKT/mTOR pathways. ascofuranone 137-149 vimentin Homo sapiens 100-108 32764455-7 2020 In addition, Western blot analysis showed that the simultaneous inhibition of miR-944 and DeltaNp63 reduced EMT by increasing the expression of epithelial markers such as claudin and by decreasing mesenchymal markers such as N-cadherin and vimentin. deltanp63 90-99 vimentin Homo sapiens 240-248 32748663-6 2021 Silibinin attenuated EMT through decreased expression of N- cadherin and vimentin and increased expression of (E-cadherin). Silybin 0-9 vimentin Homo sapiens 73-81 32727781-5 2020 In addition, CTAB reduced the levels of metastasis-related proteins including c-Met, phosphoinositide 3-kinase (PI3K), Akt, mammalian target of rapamycin (mTOR), ribosomal protein S6 kinase (p70S6K), Twist, N-cadherin, and Vimentin. Cetrimonium 13-17 vimentin Homo sapiens 223-231 32493819-8 2020 However, chemical disruption of the vimentin network by acrylamide resulted in a significant decrease in viral yield, suggesting that an intact vimentin network is needed for FMDV replication. Acrylamide 56-66 vimentin Homo sapiens 36-44 32717907-5 2020 When compared with the previously reported hydrazone series, hydrazine but not hydrazide analogs showed similarly potent inhibitory activity on VIM-type enzymes, especially VIM-2 and VIM-4, with Ki values in the micromolar to submicromolar range. hydrazine 61-70 vimentin Homo sapiens 144-147 32645972-0 2020 Development of a Gene Delivery System of Oligonucleotides for Fibroses by Targeting Cell-Surface Vimentin-Expressing Cells with N-Acetylglucosamine-Bearing Polymer-Conjugated Polyethyleneimine. Oligonucleotides 41-57 vimentin Homo sapiens 97-105 32645972-2 2020 Herein, we focused on targeting the cytoskeletal proteins vimentin, which are reportedly highly expressed on the surface of these cells and have N-acetylglucosamine (GlcNAc)-binding activity. Acetylglucosamine 145-164 vimentin Homo sapiens 58-66 32645972-2 2020 Herein, we focused on targeting the cytoskeletal proteins vimentin, which are reportedly highly expressed on the surface of these cells and have N-acetylglucosamine (GlcNAc)-binding activity. Acetylglucosamine 166-172 vimentin Homo sapiens 58-66 32645972-3 2020 A GlcNAc-bearing polymer synthesized via radical polymerization with a reversible addition-fragmentation chain transfer reagent has been previously found to interact with cell-surface vimentin-expressing cells. Acetylglucosamine 2-8 vimentin Homo sapiens 184-192 32645972-3 2020 A GlcNAc-bearing polymer synthesized via radical polymerization with a reversible addition-fragmentation chain transfer reagent has been previously found to interact with cell-surface vimentin-expressing cells. Polymers 17-24 vimentin Homo sapiens 184-192 32645972-4 2020 We designed a GlcNAc-bearing polymer-conjugated polyethyleneimine (PEI), as the gene carrier to target cell-surface vimentin-expressing cells and specifically deliver nuclear factor-kappaB decoy oligonucleotides (ODNs) and heat shock protein 47 (HSP47)-small interfering RNA (siRNA) to normal human dermal fibroblasts (NHDFs) that express cell-surface vimentin. Acetylglucosamine 14-20 vimentin Homo sapiens 116-124 32645972-4 2020 We designed a GlcNAc-bearing polymer-conjugated polyethyleneimine (PEI), as the gene carrier to target cell-surface vimentin-expressing cells and specifically deliver nuclear factor-kappaB decoy oligonucleotides (ODNs) and heat shock protein 47 (HSP47)-small interfering RNA (siRNA) to normal human dermal fibroblasts (NHDFs) that express cell-surface vimentin. Acetylglucosamine 14-20 vimentin Homo sapiens 352-360 32645972-4 2020 We designed a GlcNAc-bearing polymer-conjugated polyethyleneimine (PEI), as the gene carrier to target cell-surface vimentin-expressing cells and specifically deliver nuclear factor-kappaB decoy oligonucleotides (ODNs) and heat shock protein 47 (HSP47)-small interfering RNA (siRNA) to normal human dermal fibroblasts (NHDFs) that express cell-surface vimentin. Polymers 29-36 vimentin Homo sapiens 116-124 32645972-4 2020 We designed a GlcNAc-bearing polymer-conjugated polyethyleneimine (PEI), as the gene carrier to target cell-surface vimentin-expressing cells and specifically deliver nuclear factor-kappaB decoy oligonucleotides (ODNs) and heat shock protein 47 (HSP47)-small interfering RNA (siRNA) to normal human dermal fibroblasts (NHDFs) that express cell-surface vimentin. Polymers 29-36 vimentin Homo sapiens 352-360 32645972-4 2020 We designed a GlcNAc-bearing polymer-conjugated polyethyleneimine (PEI), as the gene carrier to target cell-surface vimentin-expressing cells and specifically deliver nuclear factor-kappaB decoy oligonucleotides (ODNs) and heat shock protein 47 (HSP47)-small interfering RNA (siRNA) to normal human dermal fibroblasts (NHDFs) that express cell-surface vimentin. Polyethyleneimine 48-65 vimentin Homo sapiens 116-124 32645972-4 2020 We designed a GlcNAc-bearing polymer-conjugated polyethyleneimine (PEI), as the gene carrier to target cell-surface vimentin-expressing cells and specifically deliver nuclear factor-kappaB decoy oligonucleotides (ODNs) and heat shock protein 47 (HSP47)-small interfering RNA (siRNA) to normal human dermal fibroblasts (NHDFs) that express cell-surface vimentin. Polyethyleneimine 48-65 vimentin Homo sapiens 352-360 32645972-4 2020 We designed a GlcNAc-bearing polymer-conjugated polyethyleneimine (PEI), as the gene carrier to target cell-surface vimentin-expressing cells and specifically deliver nuclear factor-kappaB decoy oligonucleotides (ODNs) and heat shock protein 47 (HSP47)-small interfering RNA (siRNA) to normal human dermal fibroblasts (NHDFs) that express cell-surface vimentin. Polyethyleneimine 67-70 vimentin Homo sapiens 116-124 32645972-4 2020 We designed a GlcNAc-bearing polymer-conjugated polyethyleneimine (PEI), as the gene carrier to target cell-surface vimentin-expressing cells and specifically deliver nuclear factor-kappaB decoy oligonucleotides (ODNs) and heat shock protein 47 (HSP47)-small interfering RNA (siRNA) to normal human dermal fibroblasts (NHDFs) that express cell-surface vimentin. Polyethyleneimine 67-70 vimentin Homo sapiens 352-360 32645972-5 2020 The results showed that the expression of tumor necrosis factor-alpha in lipopolysaccharide-stimulated NHDFs and HSP47 in transforming growth factor-beta1-stimulated NHDFs was suppressed by cellular uptake of the GlcNAc-bearing polymer-conjugated PEI/nuclear factor (NF)-kappaB decoy ODNs and HSP47-siRNA complexes through cell-surface vimentin, respectively. nhdfs 103-108 vimentin Homo sapiens 336-344 32437896-7 2020 AlCl3-exposed cells showed decreased E-cadherin and increased vimentin and Snail. Aluminum Chloride 0-5 vimentin Homo sapiens 62-70 32842802-11 2020 Vanillin enhanced E-cadherin expression and decreased the mesenchymal markers N-cadherin and vimentin in the irradiated lung tissue. vanillin 0-8 vimentin Homo sapiens 93-101 32377752-16 2020 In addition, curcumin and IL-6-neutralizing antibody treatment suppressed PSC-CM-modulated pancreatic cancer invasion, EMT and the changes in the expression of E-cadherin, vimentin and matrix metallopeptidase-9. Curcumin 13-21 vimentin Homo sapiens 172-180 32902409-0 2020 CD44 and vimentin, markers involved with epithelial-mesenchymal transition: A proteomic analysis of sequential proteins extraction of triple-negative breast cancer cells after treatment with all-trans retinoic acid. Tretinoin 191-214 vimentin Homo sapiens 9-17 32902409-7 2020 We have found that all-trans retinoic acid results in significantly reduced levels of vimentin and CD44 in both the cytoplasmic and membrane fractions. Tretinoin 29-42 vimentin Homo sapiens 86-94 32575795-12 2020 The results showed that BA-5 treatment inhibited HCC and HCC-SR cell migration and reduced Vimentin protein expression. ba-5 24-28 vimentin Homo sapiens 91-99 32981897-6 2020 Furthermore, BPA suppressed integrin beta1, integrin alpha5, and vimentin. bisphenol A 13-16 vimentin Homo sapiens 65-73 32585813-4 2020 Here, we evaluate whether Withaferin-A (WFA), an established disruptor of vimentin filaments, can also be used to modulate keratin filament assembly. withaferin A 26-38 vimentin Homo sapiens 74-82 32585813-4 2020 Here, we evaluate whether Withaferin-A (WFA), an established disruptor of vimentin filaments, can also be used to modulate keratin filament assembly. withaferin A 40-43 vimentin Homo sapiens 74-82 32585813-5 2020 Our results show that in keratinocytes, which are keratin-rich but vimentin-absent, Withaferin-A disrupts keratin filaments. withaferin A 84-96 vimentin Homo sapiens 67-75 32452677-4 2020 In cultured BEAS-2B cells, the protein expression levels of E-cadherin, alpha-SMA and Vimentin were 0.66 +- 0.20, 1.44 +- 0.23 and 1.32 +- 0.21 in LPS group vs 1.11 +- 0.36 (P<0.05), 1.04 +- 0.30 (P<0.05) and 0.96 +- 0.13 (P<0.01) in LPS + SP group (mean +- standard deviation), respectively. sodium propionate 240-242 vimentin Homo sapiens 86-94 32647679-13 2020 miR-328-3p overexpression significantly downregulated the percentage of Ki67 positive cells, N-cadherin positive cells and vimentin positive cells. mir-328-3p 0-10 vimentin Homo sapiens 123-131 32550826-14 2020 The specific mechanism of circHIPK3 was related to the effect of miR-485-3p on partially reversing the up-regulated expressions of Clever caspase-3, Bax, E-Cadherin and down-regulated expressions of Bcl-2, N-Cadherin and Vimentin. mir-485-3p 65-75 vimentin Homo sapiens 221-229 32633376-14 2020 The knockdown of VIM-AS1/overexpression of miR-105-5p inhibited glioma cell growth, colony formation, and migration, and enhanced the cell apoptosis by inhibiting expression of Cyclin A1, PCNA, Vimentin, N-cadherin, and Bcl-2, and by increasing the expression of Bax and E-cadherin. mir-105-5p 43-53 vimentin Homo sapiens 194-202 32086539-9 2020 Notably, precursor lymphocytes that specifically reacted to these phosphorylated vimentin-derived peptides were detected in CRC patients. Peptides 98-106 vimentin Homo sapiens 81-89 32536866-18 2020 Further study showed that shikonin decreased the levels of STAT3-targeted genes Mcl-1, Bcl-2, MMP-2, vimentin, and Twist, which are involved in melanoma survival, migration, and invasion. shikonin 26-34 vimentin Homo sapiens 101-109 32529872-8 2020 Furthermore, BBD inhibited the expression of N-cadherin, vimentin, zinc finger E-box binding homeobox (ZEB)1, ZEB2, Twist1, matrix metalloproteinase (MMP)2, MMP9, TGF-beta1, and p-Smad2/3, whereas E-cadherin expression was increased in AGS and MGC80-3 cells to different degrees. 5-tert-butyl-1,3-benzodioxole 13-16 vimentin Homo sapiens 57-65 32391111-10 2020 Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, an ERK. Curcumin 13-21 vimentin Homo sapiens 96-104 32547080-15 2020 MiR-181c-5p overexpression inhibited tumorigenesis in cervical SCC tissues; the expressions of Ki67, Caspase-3, CD44 and Vimentin in vivo were consistent with those in vitro. mir-181c-5p 0-11 vimentin Homo sapiens 121-129 32645972-5 2020 The results showed that the expression of tumor necrosis factor-alpha in lipopolysaccharide-stimulated NHDFs and HSP47 in transforming growth factor-beta1-stimulated NHDFs was suppressed by cellular uptake of the GlcNAc-bearing polymer-conjugated PEI/nuclear factor (NF)-kappaB decoy ODNs and HSP47-siRNA complexes through cell-surface vimentin, respectively. nhdfs 166-171 vimentin Homo sapiens 336-344 32645972-5 2020 The results showed that the expression of tumor necrosis factor-alpha in lipopolysaccharide-stimulated NHDFs and HSP47 in transforming growth factor-beta1-stimulated NHDFs was suppressed by cellular uptake of the GlcNAc-bearing polymer-conjugated PEI/nuclear factor (NF)-kappaB decoy ODNs and HSP47-siRNA complexes through cell-surface vimentin, respectively. Acetylglucosamine 213-219 vimentin Homo sapiens 336-344 32645972-6 2020 These findings suggest that the effective and specific delivery of ODNs and siRNA for cell-surface vimentin-expressing cells such as myofibroblasts and activated stellate cells can be achieved using GlcNAc-bearing polymer-conjugated PEI. Acetylglucosamine 199-205 vimentin Homo sapiens 99-107 32645972-6 2020 These findings suggest that the effective and specific delivery of ODNs and siRNA for cell-surface vimentin-expressing cells such as myofibroblasts and activated stellate cells can be achieved using GlcNAc-bearing polymer-conjugated PEI. Polymers 214-221 vimentin Homo sapiens 99-107 32509220-5 2020 The EA treatment significantly decreased the expression of p-EGFR and Vimentin, but increased the expression of E-cadherin in both cell lines. Ellagic Acid 4-6 vimentin Homo sapiens 70-78 32443471-4 2020 Inhibition of anchorage-independent growth, invasion, and migration of the cell lines was associated with sulforaphane-induced alterations in epithelial-to-mesenchymal transition (EMT) markers of increased E-cadherin and decreased N-cadherin and vimentin expression. sulforaphane 106-118 vimentin Homo sapiens 246-254 32509166-11 2020 Moreover, APS increased expression of E-cadherin and decreased expression of N-cadherin and vimentin, indicating that it may be related to inhibition of the PD-L1/SREBP-1/EMT signaling pathway. aps 10-13 vimentin Homo sapiens 92-100 32164951-10 2020 Additionally, esculetin significantly inhibited 786-O and SN12-PM6 cell migration and invasion, the expression of E-Cadherin increased, and the expression of N-cadherin and vimentin decreased. esculetin 14-23 vimentin Homo sapiens 173-181 32462038-9 2020 Moreover, a knockdown of HOTAIR could improve the therapeutic effect of sorafenib on HCC via increasing E-cadherin and decreasing Vimentin expression. Sorafenib 72-81 vimentin Homo sapiens 130-138 32376896-5 2020 The present study showed that catechol suppressed not only the morphological changes to the mesenchymal phenotype of epithelial HCC cells, but also the reduction of E-cadherin and the increment of Vimentin, which are typical hallmark of EMT. catechol 30-38 vimentin Homo sapiens 197-205 32106373-5 2020 In the study, the results showed that miR-451a exhibited a significant role in suppressing the drug resistance in lung cancer cells when treated with doxorubicin (DOX) through alleviating epithelialmesenchymal transition (EMT), as evidenced by the markedly reduced expression of N-cadherin and Vimentin, while the enhanced expression of E-cadherin. Doxorubicin 150-161 vimentin Homo sapiens 294-302 32106373-5 2020 In the study, the results showed that miR-451a exhibited a significant role in suppressing the drug resistance in lung cancer cells when treated with doxorubicin (DOX) through alleviating epithelialmesenchymal transition (EMT), as evidenced by the markedly reduced expression of N-cadherin and Vimentin, while the enhanced expression of E-cadherin. Doxorubicin 163-166 vimentin Homo sapiens 294-302 32742595-9 2020 Existence of bla IMP conferred more resistance to cephalotin, fosfomycin, and piperacillin (P<=0.01) and carrying bla VIM caused more resistance to cephalotin, cefepime, and ceftazidime (P<=0.01). Cephalothin 148-158 vimentin Homo sapiens 118-121 32742595-9 2020 Existence of bla IMP conferred more resistance to cephalotin, fosfomycin, and piperacillin (P<=0.01) and carrying bla VIM caused more resistance to cephalotin, cefepime, and ceftazidime (P<=0.01). Cefepime 160-168 vimentin Homo sapiens 118-121 32742595-9 2020 Existence of bla IMP conferred more resistance to cephalotin, fosfomycin, and piperacillin (P<=0.01) and carrying bla VIM caused more resistance to cephalotin, cefepime, and ceftazidime (P<=0.01). Ceftazidime 174-185 vimentin Homo sapiens 118-121 32308771-11 2020 Meanwhile, combinative treatment of beta-elemene and cetuximab inhibited cell migration and decreased the expression of mesenchymal markers (Vimentin, N-cadherin, Slug, Snail and MMP-9), but promoted the expression of epithelial marker E-cadherin. beta-elemene 36-48 vimentin Homo sapiens 141-149 32064884-10 2020 MiR-769-5p restrained Bcl-2, MMP9, N-cadherin, and Vimentin protein level and accelerated Bax, cleaved-caspase 3 and, E-cadherin protein level, while JAK1 partly overturned these effects. ABT-769 0-10 vimentin Homo sapiens 51-59 32323848-6 2020 Moreover, TP effectively increased the sensitivity of drug resistant A549 cells to gefitinib by upregulating E-cadherin protein expression and downregulating the MMP9, SNAIL, and vimentin expression levels. triptolide 10-12 vimentin Homo sapiens 179-187 32355035-8 2020 MiR-1298-3p agonist downregulated the NID1 and vimentin levels, but upregulated the level of E-cadherin in glioma cells. mir-1298 0-8 vimentin Homo sapiens 47-55 32425601-13 2020 Mechanistic studies revealed that EVO suppresses metastatic through suppressing epithelial-mesenchymal transition (EMT) as indicated by elevating the expression of epithelial marker E-cadherin and reducing the expression of mesenchymal markers N-cadherin and vimentin, as well as EMT transcription factors Snail and MMPs. evodiamine 34-37 vimentin Homo sapiens 259-267 32349289-7 2020 In addition, sinomenine significantly increases the expression of the epithelial marker E-cadherin but concomitantly decreases the expression of the mesenchymal marker vimentin, suggesting that it suppresses epithelial-mesenchymal transition (EMT). sinomenine 13-23 vimentin Homo sapiens 168-176 32018013-8 2020 Treatment with siRNA against vimentin attenuated the glucose-lowering effect of dreh depletion. Glucose 53-60 vimentin Homo sapiens 29-37 32018013-9 2020 These results suggest that the repression of dreh facilitates glucose transport via increased GLUT4 expression in the plasma membrane through the involvement of vimentin in 3T3-L1 adipocytes. Glucose 62-69 vimentin Homo sapiens 161-169 31797734-4 2020 MiR-381-3p could target NASP, reduce the expression of MMP-2 and MMP-9, Vimentin, repress the cell viability, invasion, and migration, and promote the expression of E-cadherin in AMC-HN-3 cells. mir-381-3p 0-10 vimentin Homo sapiens 72-80 32317303-5 2020 The HRs and 95% CIs for incident type 2 diabetes increased according to advance in quartiles of eGFR-VIM (HR (95% CI): Q2, 1.068 (1.009 to 1.130); Q3, 1.077 (1.018 to 1.138); Q4, 1.203 (1.139 to 1.270)) even after adjusting for confounding factors including mean eGFR and mean fasting plasma glucose levels. Glucose 292-299 vimentin Homo sapiens 101-104 32168416-6 2020 The expression level of E-cadherin was significantly increased, and the expression of vimentin, snail and slug was reduced after administration of oridonin. oridonin 147-155 vimentin Homo sapiens 86-94 32168416-10 2020 Immunohistochemical analysis further revealed that oridonin increased E-cadherin expression and reduced vimentin and phospho-FAK levels in vivo. oridonin 51-59 vimentin Homo sapiens 104-112 32269737-4 2020 The present study found that both the Cox-2 inhibitor celecoxib and the EP2 antagonist PF-04418948 upregulated CDH-1 expression, restored membranous localization of E-cadherin, and reduced vimentin expression, by downregulating the transcriptional repressors of E-cadherin in BICR6 and FaDu cells. Celecoxib 54-63 vimentin Homo sapiens 189-197 32466394-10 2020 The inhibition of vimentin with FiVe1 resulted in a significant sensitization of A2780 and A2780cis cells to cisplatin, revealing new possibilities for improving the chemosensitivity of ovarian cancer cells. Cisplatin 109-118 vimentin Homo sapiens 18-26 32088750-8 2020 There were significant correlations between plasma vimentin levels and OSA patients" AHI and mean oxygen desaturation (r = 0.46, p = 0.001; r = 0.214, p = 0.005). Oxygen 98-104 vimentin Homo sapiens 51-59 32088750-9 2020 CONCLUSION: In this study, we observed significant positive correlations between plasma vimentin level and OSA severity, weight, AHI, and mean oxygen desaturation. Oxygen 143-149 vimentin Homo sapiens 88-96 32626875-11 2020 After disulfiram + TGF-beta1 treatment, as the concentration of disulfiram increased, the morphological changes of SCC-25 and CAL-27 cells gradually decreased, the expression of E-cadherin protein gradually increased, the expression of Vimentin and Snail protein gradually decreased, and migration ability gradually weakened (P<0.05). Disulfiram 6-16 vimentin Homo sapiens 236-244 32244501-7 2020 Treatment of vimentin with micromolar ZnCl2 induces fibril-like particles that do not assemble into filaments, but form aggregates upon subsequent addition of NaCl. zinc chloride 38-43 vimentin Homo sapiens 13-21 32244501-7 2020 Treatment of vimentin with micromolar ZnCl2 induces fibril-like particles that do not assemble into filaments, but form aggregates upon subsequent addition of NaCl. Sodium Chloride 159-163 vimentin Homo sapiens 13-21 32244501-8 2020 In contrast, when added to NaCl-polymerized vimentin, zinc increases the diameter or induces lateral association of vimentin wt filaments. Sodium Chloride 27-31 vimentin Homo sapiens 44-52 32244501-8 2020 In contrast, when added to NaCl-polymerized vimentin, zinc increases the diameter or induces lateral association of vimentin wt filaments. Sodium Chloride 27-31 vimentin Homo sapiens 116-124 32244501-10 2020 Therefore, the zinc-vimentin interaction depends on the chemical environment and on the assembly state of the protein, leading to atypical polymerization of soluble vimentin, likely through electrostatic interactions, or to broadening and lateral association of preformed filaments through mechanisms requiring the cysteine residue. Cysteine 315-323 vimentin Homo sapiens 20-28 32269737-4 2020 The present study found that both the Cox-2 inhibitor celecoxib and the EP2 antagonist PF-04418948 upregulated CDH-1 expression, restored membranous localization of E-cadherin, and reduced vimentin expression, by downregulating the transcriptional repressors of E-cadherin in BICR6 and FaDu cells. 1-(4-fluorobenzoyl)-3-(((6-methoxy-2-naphthyl)oxy)methyl)azetidine-3-carboxylic acid 87-98 vimentin Homo sapiens 189-197 32231566-9 2020 SA could decrease N-cadherin, Snail, Vimentin, and PD-L1 expression. sativan 0-2 vimentin Homo sapiens 37-45 32143529-7 2020 Both treatments reduced the levels of SCD1, phospho-Rac1/Cdc42/Rac1/Cdc42 ratio, Cofilin, Vimentin, and phospho-Paxillin especially in Caco2 compared to SW480, showing a different behavior of the two cell lines to these natural compounds. caco2 135-140 vimentin Homo sapiens 90-98 32047071-7 2020 CONCLUSION: Overall, tremor control with VIM DBS in DT and ET was comparable and remained sustained at long term likely related to intervention at the final common node in the pathologic tremor network. Thymidine 52-54 vimentin Homo sapiens 41-44 32047071-9 2020 These findings from a large cohort of DT indicate that VIM targeting is reasonable if the tremor is considerably more disabling than the dystonic features. Thymidine 38-40 vimentin Homo sapiens 55-58 32256964-6 2020 More interestingly, DpdtC could also inhibit EMT, leading to the upregulation of E-cadherin and the downregulation of vimentin; however, the addition of NAC and 3-MA could attenuate (or neutralize) the action of DpdtC on ferritinophagy induction and EMT inhibition, supporting that the enhanced ferritinophagic flux contributed to the EMT inhibition. di-n-propyldithiocarbamate 20-25 vimentin Homo sapiens 118-126 32256964-6 2020 More interestingly, DpdtC could also inhibit EMT, leading to the upregulation of E-cadherin and the downregulation of vimentin; however, the addition of NAC and 3-MA could attenuate (or neutralize) the action of DpdtC on ferritinophagy induction and EMT inhibition, supporting that the enhanced ferritinophagic flux contributed to the EMT inhibition. 3-methyladenine 161-165 vimentin Homo sapiens 118-126 31760768-8 2020 The results from the in vivo study showed that OA-NO2 notably relieved peritoneal fibrosis by decreasing the thickness of the peritoneum; it also inhibited the expression of TGF-beta1, alpha-SMA, N-cadherin and vimentin and enhanced the expression of E-cadherin in the peritoneum. Aligeron 50-53 vimentin Homo sapiens 211-219 32104221-4 2020 TSA-induced changes in the expression of an epithelial biomarker epithelial cadherin (E-cadherin), a mesenchymal biomarker (vimentin), and a transcription factor [zinc finger protein SNAI2 (SLUG)] were also investigated. trichostatin A 0-3 vimentin Homo sapiens 124-132 32104221-6 2020 Treatment with TSA led to an increased expression level of E-cadherin, and decreased expression of vimentin and, in MCF-7 cells. trichostatin A 15-18 vimentin Homo sapiens 99-107 31721324-0 2020 LncRNA BC088259 promotes Schwann cell migration through Vimentin following peripheral nerve injury. N(6)-butyrylcordycepin 7-15 vimentin Homo sapiens 56-64 31721324-7 2020 Mechanistically, BC088259 might exert this regulatory role by directly binding with Vimentin. N(6)-butyrylcordycepin 17-25 vimentin Homo sapiens 84-92 31713924-2 2020 Therefore, this study was aimed to study the effect of applying linoleic acid (LA) and docosahexaenoic acid (DHA) fatty acids alone or combined with Taxol on the expression of the matrix metalloproteinase (MMP)-9, MMP-2, vimentin, and talin2 genes, tumor-suppressor miR-194 and, onco-miR-106b in triple-negative breast cancer cell line, known as MDA-MB-231. Docosahexaenoic Acids 109-112 vimentin Homo sapiens 221-229 31713924-6 2020 The results of qRT-PCR showed that treating the MDA-MB-231 cells with DHA caused an increase in the miR-194 expression and a decrease in the miR-106b expression, leading to the downregulation of the MMP-2 and MMP-9, and vimentin, and upregulation of the talin2 under the normoxic and hypoxic conditions. Docosahexaenoic Acids 70-73 vimentin Homo sapiens 220-228 31894324-5 2020 Using western-blotting and immunofluorescence, it was found that the switch in E-cadherin/N-cadherin and vimentin expression was induced by TGF-beta1, which was reversed by melatonin through the suppression of Snail and matrix metalloproteinase 9 (MMP-9), through hypoxia-inducible factor 1alpha (HIF-1alpha) inhibition. Melatonin 173-182 vimentin Homo sapiens 105-113 31811906-7 2020 Also, we observed anti-metastatic effects and changes in MMP9, E-cadherin, N-cadherin and Vimentin when cells were treated with a low dose of 2HF. 2'-hydroxyflavanone 142-145 vimentin Homo sapiens 90-98 32049991-14 2020 THC and CBD alone or in combination restored the epithelial phenotype, as evidenced by increased expression of CDH1 and reduced expression of CDH2 and VIM, as well as by fluorescence analysis of cellular cytoskeleton. Dronabinol 0-3 vimentin Homo sapiens 151-154 32049991-14 2020 THC and CBD alone or in combination restored the epithelial phenotype, as evidenced by increased expression of CDH1 and reduced expression of CDH2 and VIM, as well as by fluorescence analysis of cellular cytoskeleton. Cannabidiol 8-11 vimentin Homo sapiens 151-154 32405508-12 2020 In addition, the protein levels of vimentin and fibronectin were significantly reduced by pirfenidone (400 mug/mL) in both normal and keloid keratinocytes. pirfenidone 90-101 vimentin Homo sapiens 35-43 32047143-5 2020 In particular, vimentin (VIM), a type III intermediate filament protein involved in cytoskeleton organization and cell motility, was SUMOylated by PIAS1 at Lys-439 and Lys-445 residues. pentalysine 156-159 vimentin Homo sapiens 15-23 32047143-5 2020 In particular, vimentin (VIM), a type III intermediate filament protein involved in cytoskeleton organization and cell motility, was SUMOylated by PIAS1 at Lys-439 and Lys-445 residues. pentalysine 156-159 vimentin Homo sapiens 25-28 32047143-5 2020 In particular, vimentin (VIM), a type III intermediate filament protein involved in cytoskeleton organization and cell motility, was SUMOylated by PIAS1 at Lys-439 and Lys-445 residues. pentalysine 168-171 vimentin Homo sapiens 15-23 32047143-5 2020 In particular, vimentin (VIM), a type III intermediate filament protein involved in cytoskeleton organization and cell motility, was SUMOylated by PIAS1 at Lys-439 and Lys-445 residues. pentalysine 168-171 vimentin Homo sapiens 25-28 31743135-9 2020 Moreover, BBR inhibited the expression of Bax, Bcl-2, c-Myc, and Vimentin and up-regulated the cytokeratin expression in SW480 cells. Berberine 10-13 vimentin Homo sapiens 65-73 32010270-9 2020 The present results suggested that AL treatment increased the expression level of E-cadherin, but decreased the expression levels of N-cadherin, matrix metalloproteinase (MMP)-9 and vimentin in SCC13 cells. avicularin 35-37 vimentin Homo sapiens 182-190 31408253-2 2020 The histone mark histone 3 lysine 4 acetylation (H3K4Ac) is observed in the promoter regions of various EMT marker genes (eg, CDH1 and VIM). Lysine 27-33 vimentin Homo sapiens 135-138 31243341-4 2020 This work sought to define how differential modulation of the calcium signal effects the induction of vimentin and the Ca2+ influx pathways involved. Calcium 62-69 vimentin Homo sapiens 102-110 31243341-6 2020 EGTA-AM- and thapsigargin-mediated induction of vimentin expression in MDA-MB-468 cells involves store-operated Ca2+ entry, as evidenced by sensitivity to silencing of the molecular components of this pathway, STIM1 and ORAI1. EGTA acetoxymethyl ester 0-7 vimentin Homo sapiens 48-56 31243341-6 2020 EGTA-AM- and thapsigargin-mediated induction of vimentin expression in MDA-MB-468 cells involves store-operated Ca2+ entry, as evidenced by sensitivity to silencing of the molecular components of this pathway, STIM1 and ORAI1. Thapsigargin 13-25 vimentin Homo sapiens 48-56 31243341-9 2020 Subsequent studies identified that EGTA-AM-induced vimentin expression also partially involved a TRPC1-dependent pathway. EGTA acetoxymethyl ester 35-42 vimentin Homo sapiens 51-59 31629898-6 2020 The BPA-induced EMT was illustrated by morphologic changes, E/N-cadherin switch and vimentin/Snail-1/connexin(Cx)43 up-regulation in A549 populations. bisphenol A 4-7 vimentin Homo sapiens 84-92 31840737-10 2020 In addition, phosphatidylinositol 3"-kinase/protein kinase B (PI3K/AKT) signal pathway was suppressed by ISL treatment, and the epithelial marker E-cadherin was up-regulated when the mesenchymal markers Vimentin and N-cadherin were down-regulated. isoliquiritigenin 105-108 vimentin Homo sapiens 203-211 32027294-5 2020 5% (40%-90%), which suggests that CD4, CD43, LCA, CD123, and VIM were the most sensitive antigens for diagnosing BPDCN. bpdcn 113-118 vimentin Homo sapiens 61-64 32099461-8 2020 Paeonol inhibited epithelial-mesenchymal-transition by upregulating E-cadherin, and down regulating N-cadherin and vimentin expressions. paeonol 0-7 vimentin Homo sapiens 115-123 31973707-15 2020 Furthermore, our studies showed that circPTK2 could promote EMT of CRC cells in vitro and in vivo by binding to vimentin protein on sites Ser38, Ser55 and Ser82. seryl-seryl-seryl-arginine 138-141 vimentin Homo sapiens 112-120 31973707-15 2020 Furthermore, our studies showed that circPTK2 could promote EMT of CRC cells in vitro and in vivo by binding to vimentin protein on sites Ser38, Ser55 and Ser82. seryl-seryl-seryl-arginine 145-148 vimentin Homo sapiens 112-120 31973707-15 2020 Furthermore, our studies showed that circPTK2 could promote EMT of CRC cells in vitro and in vivo by binding to vimentin protein on sites Ser38, Ser55 and Ser82. seryl-seryl-seryl-arginine 145-148 vimentin Homo sapiens 112-120 32056556-9 2020 Optimum AMC growth was also between 2 and 8 kP A, with predominance of vimentin; however, AMCs did not form 3D structures. 7-amino-4-methylcoumarin 8-11 vimentin Homo sapiens 71-79 32056556-10 2020 Lower and higher rigidities transitioned AMCs into AECs (decrease in vimentin). amcs 41-45 vimentin Homo sapiens 69-77 32103900-12 2020 In addition, shikonin decreased Vimentin, increased E-cadherin protein expressions and E-cadherin promoter activity, the latter was reversed in cells transfected with exogenous Snail overexpression vectors. shikonin 13-21 vimentin Homo sapiens 32-40 31936664-10 2020 EGCG significantly downregulated the expression of vascular endothelial cadherin (VE-cadherin) and its transcription factor, twist, N-cadherin, vimentin, phosphor-AKT, and AKT, but not phospho-erythropoietin-producing hepatocellular receptor A2 (EphA2) and EphA2. epigallocatechin gallate 0-4 vimentin Homo sapiens 144-152 31729097-8 2020 Moreover, calcitriol suppressed E-cadherin downregulation and vimentin upregulation not only in TGF-beta1-stimulated but also in TGF-beta1-unstimulated ACHN and CAKI-2 cells. Calcitriol 10-20 vimentin Homo sapiens 62-70 31564085-0 2020 Vimentin as a potential therapeutic target in sorafenib resistant HepG2, a HCC model cell line. sorafenib 46-55 vimentin Homo sapiens 0-8 31564085-8 2020 Furthermore, withaferin A was used to study regulation of vimentin expression and its significance in sorafenib resistance. withaferin A 13-25 vimentin Homo sapiens 58-66 31564085-8 2020 Furthermore, withaferin A was used to study regulation of vimentin expression and its significance in sorafenib resistance. sorafenib 102-111 vimentin Homo sapiens 58-66 31564085-10 2020 Interestingly, the study demonstrated that withaferin A further lowered the expression of vimentin in HepG2 (R) cells in a dose-dependent manner. withaferin A 43-55 vimentin Homo sapiens 90-98 31564085-11 2020 Also, inhibition of vimentin lowered ABCG2 expression and decreased cell viability in parental as well as sorafenib resistant HepG2 cells. sorafenib 106-115 vimentin Homo sapiens 20-28 31564085-12 2020 Conclusions: Hence, our study for the first time highlighted the probable therapeutic potential of vimentin in sorafenib resistant HepG2, a HCC model cell line. sorafenib 111-120 vimentin Homo sapiens 99-107 31669600-5 2020 EMT was successfully induced by oxalate treatment as indicated by morphological changes into spindle-shape cells, increased expression of mesenchymal proteins (fibronectin, vimentin and alpha-smooth muscle actin (alpha-SMA)), decreased expression of epithelial proteins (E-cadherin and zonula occludens-1 (ZO-1)) and increased activity of a profibrotic factor (matrix metalloproteinase-9 (MMP-9)). Oxalates 32-39 vimentin Homo sapiens 173-181 32116235-6 2020 RESULTS: In vitro validation experiment using miR-222-3p mimic molecules significantly induced expression of EMT marker vimentin and downregulated E-cadherin in both 769-P and 786-O RCC cells. mir-222-3p 46-56 vimentin Homo sapiens 120-128 32140187-11 2020 GSEA and co-expression gene analyses revealed that VIM and MRP1 were involved in multiple crucial biological processes and pathways. gsea 0-4 vimentin Homo sapiens 51-54 32474504-12 2020 Berberine inhibited their invasive capability as well as increased E-cadherin and decreased vimentin protein levels; this indicated that berberine suppressed the EMT process in MG-63 cells exposed to gamma-rays irradiation. Berberine 137-146 vimentin Homo sapiens 92-100 31612353-5 2020 We here report that silibinin at lower concentrations (30-90 muM) inhibits epithelial to mesenchymal transition (EMT) of MDA-MB-231, by increasing the expression of epithelial marker, E-cadherin, and decreasing the expression of mesenchymal markers, N-cadherin and vimentin. Silybin 20-29 vimentin Homo sapiens 265-273 31595775-8 2020 ACTA-2, IL-1beta, and N-cadherin immunoreactivities were significantly decreased, whereas TNF-alpha and vimentin immunoreactivities significantly increased in quercetin-treated CD133+ cells. Quercetin 159-168 vimentin Homo sapiens 104-112 31746423-10 2020 Treatment with TM or TG increased the expression of the ER stress markers glucose-regulated protein 78, phosphorylated eukaryotic initiation factor 2alpha, activating transcription factor (ATF)6, ATF4 and inositol-requiring protein 1alpha and the EMT markers fibronectin, vimentin, alpha-smooth muscle actin and neural cadherin. Tunicamycin 15-17 vimentin Homo sapiens 272-280 31746423-10 2020 Treatment with TM or TG increased the expression of the ER stress markers glucose-regulated protein 78, phosphorylated eukaryotic initiation factor 2alpha, activating transcription factor (ATF)6, ATF4 and inositol-requiring protein 1alpha and the EMT markers fibronectin, vimentin, alpha-smooth muscle actin and neural cadherin. Thapsigargin 21-23 vimentin Homo sapiens 272-280 33456077-8 2020 Furthermore, to measure the molecular weight of vimentin and alpha-enolase, electrophoresis on 10% SDS-PAGE was performed as described before. Sodium Dodecyl Sulfate 99-102 vimentin Homo sapiens 48-56 31897166-6 2020 The combination of oxymatrine and 5-FU reduced the protein expression of snail family transcriptional repressor 2 and vimentin, phosphorylated p65 and induced the expression of E-cadherin, by inhibiting the nuclear factor kappaB (NF-kappaB) signaling pathway. oxymatrine 19-29 vimentin Homo sapiens 118-126 31897166-6 2020 The combination of oxymatrine and 5-FU reduced the protein expression of snail family transcriptional repressor 2 and vimentin, phosphorylated p65 and induced the expression of E-cadherin, by inhibiting the nuclear factor kappaB (NF-kappaB) signaling pathway. Fluorouracil 34-38 vimentin Homo sapiens 118-126 31634547-0 2020 Down-regulation of vimentin by triorganotin isothiocyanates-nuclear retinoid X receptor agonists: A proteomic approach. triorganotin isothiocyanates 31-59 vimentin Homo sapiens 19-27 32406319-9 2020 Furthermore, we illustrated that desloratadine downregulated the expression of N-cadherin, Vimentin, Snail1, and Snail2, while upregulated the expression of E-cadherin in EJ and SW780 cells in vitro. desloratadine 33-46 vimentin Homo sapiens 91-99 31634547-6 2020 Both tested triorganotin compounds showed similarly reduced expression of vimentin, but tributyltin isothiocyanate (TBT-ITC) proved to be more effective than triphenyltin isothiocyanate (TPT-ITC). triorganotin 12-24 vimentin Homo sapiens 74-82 31634547-7 2020 Furthermore, the effect of natural (9cRA) and synthetic RXR ligands, both chloride and isothiocyanate derivatives, on vimentin expression was compared. Chlorides 74-82 vimentin Homo sapiens 118-126 31634547-7 2020 Furthermore, the effect of natural (9cRA) and synthetic RXR ligands, both chloride and isothiocyanate derivatives, on vimentin expression was compared. isothiocyanic acid 87-101 vimentin Homo sapiens 118-126 32042318-4 2020 And then we detected the expression of vimentin in MSCs, which further directed the MSCs to fibroblasts through Western blotting and Immunofluorescence when treated with CuS@BSA or pre-heat at 42 C. In addition, we implanted MSCs into the Matrigel or electrospun PLA nanofiber membrane in vitro to evaluating the effect of heating or CuS@BSA on the morphological change of MSCs by SEM. cupric sulfide 170-173 vimentin Homo sapiens 39-47 32042318-4 2020 And then we detected the expression of vimentin in MSCs, which further directed the MSCs to fibroblasts through Western blotting and Immunofluorescence when treated with CuS@BSA or pre-heat at 42 C. In addition, we implanted MSCs into the Matrigel or electrospun PLA nanofiber membrane in vitro to evaluating the effect of heating or CuS@BSA on the morphological change of MSCs by SEM. cupric sulfide 335-338 vimentin Homo sapiens 39-47 32042318-7 2020 Not only CuS nanoparticles itself or after irradiation at 980 nm stimulated the expressioin of vimentin in MSCs. cupric sulfide 9-12 vimentin Homo sapiens 95-103 31920328-12 2019 Significantly decreased colony number, migration and invasion number, higher E-cadherin protein expression and lower Snail, Vimentin, MMP-2 and MMP-9 proteins expression were found in AsPC1 cells of the siTMEFF2+ SB203580 group when compared with the siTMEFF2+ DMSO group. SB 203580 213-221 vimentin Homo sapiens 124-132 31862882-0 2019 RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers. Estrogens 11-19 vimentin Homo sapiens 57-65 31862882-6 2019 Mechanistically, RNF208 specifically polyubiquitinated the Lys97 residue within the head domain of Vimentin through interaction with the Ser39 residue of phosphorylated Vimentin, which exists as a soluble form, eventually facilitating proteasomal degradation of Vimentin. seryl-seryl-seryl-arginine 137-140 vimentin Homo sapiens 99-107 31862882-6 2019 Mechanistically, RNF208 specifically polyubiquitinated the Lys97 residue within the head domain of Vimentin through interaction with the Ser39 residue of phosphorylated Vimentin, which exists as a soluble form, eventually facilitating proteasomal degradation of Vimentin. seryl-seryl-seryl-arginine 137-140 vimentin Homo sapiens 169-177 31862882-6 2019 Mechanistically, RNF208 specifically polyubiquitinated the Lys97 residue within the head domain of Vimentin through interaction with the Ser39 residue of phosphorylated Vimentin, which exists as a soluble form, eventually facilitating proteasomal degradation of Vimentin. seryl-seryl-seryl-arginine 137-140 vimentin Homo sapiens 169-177 31861383-14 2019 The treatment of fatostatin resulted in the reduced staining of SREBP1, ZEB1, and Vim, while E-cadherin and miR-142-5p were increased. fatostatin 17-27 vimentin Homo sapiens 82-85 31626792-3 2019 5.1% sevoflurane can participate in the regulation of EMT by regulating the expression of E-cadherin, Vimentin and N-cadherin proteins. Sevoflurane 5-16 vimentin Homo sapiens 102-110 31800712-7 2019 Vimentin immunostaining showed that diosmin induced morphological changes in GBM95 and GBM02 cells, making them smaller and more polygonal. Diosmin 36-43 vimentin Homo sapiens 0-8 31730141-8 2019 Gossypol suppressed the level of p-focal adhesion kinase (FAK) and epithelial-to-mesenchymal transition markers, including N-cadherin, fibronectin and vimentin. Gossypol 0-8 vimentin Homo sapiens 151-159 31810268-8 2019 Data revealed that EMT markers, such as vimentin and SNAI2, were expressed moderately higher in the oxaliplatin-resistant cells and their expression increased further in the less drug-resistant cells, which had miR-23b knockout. oxaliplatin 100-111 vimentin Homo sapiens 40-48 31328322-7 2019 Importantly, we observed that treatment with SCH58261, a selective A2A R antagonist, restored the expression levels of several inflammatory and astrocytic activation-related genes, such as Interleukin-1beta and vimentin. 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine 45-53 vimentin Homo sapiens 211-219 31432697-7 2019 Salidroside inhibited GC cells proliferation, migration, invasion and promoted apoptosis, which coupled with the down-regulation of p21, Bcl-2, MMP2, RhoA, p-ROCK1, Vimentin and the up-regulations of CyclinD1, Bax, cleaved caspases. rhodioloside 0-11 vimentin Homo sapiens 165-173 31638188-7 2019 The present results demonstrated that compared with the normal control group, the tacrolimus nephrotoxicity group exhibited severe renal fibrosis (P<0.05), upregulated vimentin (P<0.01), downregulated E-cadherin (P<0.05) and upregulated alpha-SMA (P<0.01). Tacrolimus 82-92 vimentin Homo sapiens 171-179 31219186-11 2019 In melanoma cells transfected with miR-329 mimics or siRNA-HMGB2, cell proliferation, migration, and invasion were impeded, yet cell cycle arrest and apoptosis were promoted, corresponding to decreased levels of beta-catenin, cyclin D1, and vimentin and increased levels of GSK3beta and E-cadherin. mir-329 35-42 vimentin Homo sapiens 241-249 31807174-6 2019 The present study reported that Tan IIA treatment decreased EGF- and TGF-beta1-enhanced cell colony numbers, migration and invasion, and inhibited EGF- and TGF-beta1-induced decreases in the expression levels of E-cadherin, and increases in the expression levels of matrix metalloproteinase-2, N-cadherin, vimentin and Snail. tanshinone 32-39 vimentin Homo sapiens 306-314 31807174-8 2019 Furthermore, western blot analysis confirmed that blocking the function of PI3K/Akt and ERK with LY294002 and U0126 resulted in upregulation of E-cadherin expression, and downregulation of vimentin and Snail expression in EGF- and TGF-beta1-treated HepG2 cells. U 0126 110-115 vimentin Homo sapiens 189-197 31970141-7 2019 Diclofenac triggered a typical EMT process with downregulated E-cadherin and upregulated N-cadherin, vimentin, and Snail in PC3 cells, regardless of p53 expression. Diclofenac 0-10 vimentin Homo sapiens 101-109 32257929-1 2020 Arylquin 1, a small-molecule prostate-apoptosis-response-4 (Par-4) secretagogue, targets vimentin to induce Par-4 secretion. Arylquin 1 0-10 vimentin Homo sapiens 89-97 31199965-7 2019 Interestingly, redistribution of vimentin by NO2-POPC is attenuated in a C328S mutant, thus indicating that this residue may be a target for direct or indirect modification in NO2-POPC-treated cells. no2-popc 45-53 vimentin Homo sapiens 33-41 31199965-7 2019 Interestingly, redistribution of vimentin by NO2-POPC is attenuated in a C328S mutant, thus indicating that this residue may be a target for direct or indirect modification in NO2-POPC-treated cells. no2-popc 176-184 vimentin Homo sapiens 33-41 31199965-8 2019 Additionally, NO2-POPC interacts with several typical lipoxidation targets in vitro, including vimentin and PPARgamma constructs, likely through cysteine residues. Cysteine 145-153 vimentin Homo sapiens 95-103 31257936-9 2019 Additionally, Shikonin restrained cell migration, invasion and down-regulated MMP2, RhoA, ROCK1 and Vimentin expression in NCI-N87 cells. shikonin 14-22 vimentin Homo sapiens 100-108 31799662-8 2019 RESULTS: Transfection of miR-103 mimics into Tca8113 cells significantly upregulated miR-103 expression, decreased SALL4 mRNA and protein expression, inhibited proliferation and invasion of Tca8113 cell, downregulated MMP-9 and MMP-2 mRNA expression, increased E-cadherin, and decreased Vimentin protein expression (p<0.05). mir-103 25-32 vimentin Homo sapiens 287-295 31656722-5 2019 The expression of EMT and Vimentin in HCT116 and HT29 cells was reduced markedly on treatment with 2-amino-4-(1-piperidine) pyridine. Piperidines 99-132 vimentin Homo sapiens 26-34 31243644-5 2019 Moreover, miR-138-5p overexpression suppressed cell epithelial-mesenchymal transition (EMT) phenomenon of BC by upregulating E-cadherin expression, but downregulating N-cadherin and Vimentin expression. mir-138-5p 10-20 vimentin Homo sapiens 182-190 31599708-9 2019 A375 cells treated with overexpressed VEPH1 plasmids or/and TGF-beta signaling pathway inhibitor SB-431542 displayed diminished TGF-beta, SMAD4, Vimentin and N-cadherin expression while the expression of E-cadherin was elevated, accompanied by decreased cell proliferation, migration, invasion, inhibited cell cycle entry. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 97-106 vimentin Homo sapiens 145-153 31799662-9 2019 However, miR-103 inhibitor transfection down-regulated miR-103 expression, promoted proliferation and invasion of Tca8113 cells, increased MMP-9 and MMP-2 mRNA expression, decreased E-cadherin expression, and elevated Vimentin expression. mir-103 9-16 vimentin Homo sapiens 218-226 31436299-9 2019 The results demonstrated a significant decrease in EMT following exposure to 20 microM curcumin for 72 h. This finding was supported by a decrease in the protein expression levels of N-cadherin, Vimentin and Slug. Curcumin 87-95 vimentin Homo sapiens 195-203 31695437-12 2019 Moreover, Western blotting also showed that GDNB downregulated the levels of N-cadherin, vimentin and Snail in H510A and A549 cells in a dose-dependent manner, while it upregulated the level of E-cadherin. ganoderan B 44-48 vimentin Homo sapiens 89-97 33564439-9 2021 Transfection of miR-99a-5p in cultured human podocytes downregulated mammalian target of rapamycin (mTOR) protein expression and downregulated the podocyte injury marker vimentin. mir-99a-5p 16-26 vimentin Homo sapiens 170-178 31614564-6 2019 Also, linear regression analysis showed a significant correlation between 18F-choline uptake and the number of vimentin, RANKL, VDR, or PTX3 positive prostate cancer cells. Choline 78-85 vimentin Homo sapiens 111-119 31636898-3 2019 The production of carbapenem- hydrolysing beta-lactamases (carbapenamases), which include NDM, KPC, OXA-48, IMP-1 and VIM is the most common mechanism. Carbapenems 18-28 vimentin Homo sapiens 118-121 31589596-10 2019 C18H17NO6 treatment significantly downregulated N-cadherin and Vimentin expression levels and upregulated E-cadherin expression levels in vitro and in vivo. 18-crown-6 2,3,11,12-tetracarboxylic acid 0-9 vimentin Homo sapiens 63-71 31632077-9 2019 Moreover, LiCl (beta-catenin activator) enhanced the regulatory effects of SOX17 on the expression of E-cadherin, promigratory cadherin, vimentin, and proteins in the Wnt signaling pathway, while XAV93920 (beta-catenin inhibitor) exerted the opposite effect. Lithium Chloride 10-14 vimentin Homo sapiens 137-145 31295528-6 2019 Treatment with SFN also dramatically diminished ethanol-induced changes in the expression of E-cadherin and vimentin, and restored EMT in ethanol-exposed NCCs. sulforaphane 15-18 vimentin Homo sapiens 108-116 31295528-6 2019 Treatment with SFN also dramatically diminished ethanol-induced changes in the expression of E-cadherin and vimentin, and restored EMT in ethanol-exposed NCCs. Ethanol 48-55 vimentin Homo sapiens 108-116 31545251-7 2019 Realtime-qPCR assay shown that ART decreased the mRNA levels of proliferation related genes c-Myc, cyclin D1 and PCNA, and reduced the mRNA levels of mesenchymal genes N-cadherin, Vimentin and Snail, but increased the mRNA levels of epithelial marker E-cadherin. Artemisinins 31-34 vimentin Homo sapiens 180-188 31880524-9 2019 The levels of expression of vimentin and Snail mRNAs were significantly and dose-dependently down-regulated in esculetin-treated A549 cells, when compared with the control cells (p &lt; 0.05). esculetin 111-120 vimentin Homo sapiens 28-36 31581522-4 2019 In the current study, both messenger RNA (mRNA) and the vimentin protein were significantly increased in a time-dependent manner in the dimethylnitrosamine (DMN)-exposed liver. Dimethylnitrosamine 136-155 vimentin Homo sapiens 56-64 31581522-4 2019 In the current study, both messenger RNA (mRNA) and the vimentin protein were significantly increased in a time-dependent manner in the dimethylnitrosamine (DMN)-exposed liver. Dimethylnitrosamine 157-160 vimentin Homo sapiens 56-64 31581522-10 2019 Inhibitors of selected signaling pathways suppressed the migration and differentiation of activated HSCs by regulating specific serine phosphorylated sites on vimentin. Serine 128-134 vimentin Homo sapiens 159-167 31364739-10 2019 In addition, epithelial-mesenchymal transition occurred upon ROS accumulation, whereas the effects of H2O2 on AQP1 and vimentin expression were reversed upon LC supplementation. Hydrogen Peroxide 102-106 vimentin Homo sapiens 119-127 31524277-10 2019 Exposure to PFOA also induced the expression of vimentin, SGK1, cyclin E2, CDK2, AKT, PI3K and Bcl-2, but suppressed the expression of Bax in the RD cells. perfluorooctanoic acid 12-16 vimentin Homo sapiens 48-56 31880524-11 2019 These results demonstrate that esculetin effectively inhibits the proliferation of A549 cells, and regulates EMT of the cells via the down-regulation of vimentin and Snail, and up-regulation of E-cadherin expressions. esculetin 31-40 vimentin Homo sapiens 153-161 31569795-5 2019 Treatments with withaferin A or acrylamide show that cell motility can be modulated by regulating vimentin assembly. withaferin A 16-28 vimentin Homo sapiens 98-106 31569795-5 2019 Treatments with withaferin A or acrylamide show that cell motility can be modulated by regulating vimentin assembly. Acrylamide 32-42 vimentin Homo sapiens 98-106 31742196-3 2019 Among the "non-diagnostic" antibodies, a few studies have suggested that the IgG anti-vimentin/cardiolipin antibodies (AVA/CL) may be associated with risk of thrombosis. Cardiolipins 95-106 vimentin Homo sapiens 86-94 31467176-4 2019 Moreover, Isorhamnetin effectively suppressed the expressions of epithelial-to-mesenchymal transition (EMT) markers, as evidenced by the down-regulation of N-cadherin, vimentin and snail, as well as up-regulation of E-cadherin protein expression. 3-methylquercetin 10-22 vimentin Homo sapiens 168-176 31334536-5 2019 By investigating networks formed from tail-truncated vimentin, in which noncovalent crosslinking is suppressed, and glutaraldehyde-treated vimentin, in which crosslinking is made permanent, we show that rate-dependent inelastic fluidization is a direct consequence of vimentin"s transient crosslinking. Glutaral 116-130 vimentin Homo sapiens 139-147 31334536-5 2019 By investigating networks formed from tail-truncated vimentin, in which noncovalent crosslinking is suppressed, and glutaraldehyde-treated vimentin, in which crosslinking is made permanent, we show that rate-dependent inelastic fluidization is a direct consequence of vimentin"s transient crosslinking. Glutaral 116-130 vimentin Homo sapiens 139-147 31571901-9 2019 High-dose VC increased E-cadherin and reduced Vimentin, indicating that high-dose VC suppressed epithelial-mesenchymal transition (EMT) in breast cancer cells. Ascorbic Acid 10-12 vimentin Homo sapiens 46-54 31571901-9 2019 High-dose VC increased E-cadherin and reduced Vimentin, indicating that high-dose VC suppressed epithelial-mesenchymal transition (EMT) in breast cancer cells. Ascorbic Acid 82-84 vimentin Homo sapiens 46-54 31571901-11 2019 Meanwhile, high-dose VC reversed the suppression of E-cadherin and enhancement of Vimentin induced by TGF-beta1 in breast cancer cells. Ascorbic Acid 21-23 vimentin Homo sapiens 82-90 31477108-15 2019 Furthermore, by analyzing GEO datasets and using molecular methods, we explored a kinase, Lyn, its expression correlated with the expression of E-cadherin, vimentin and alpha-SMA in CS-exposed model. Cesium 182-184 vimentin Homo sapiens 156-164 31410143-10 2019 The current study also demonstrated that treatment with gefitinib suppressed epithelial-mesenchymal transition (EMT) as the expression level of the epithelial marker, E-cadherin was increased, while the expression level of the mesenchymal marker, vimentin was decreased. Gefitinib 56-65 vimentin Homo sapiens 247-255 31176166-9 2019 Furthermore, melatonin reversed changes in the expression of EMT markers induced by IL-1beta by increasing mRNA levels of beta-catenin and E-cadherin and decreasing those of fibronectin, vimentin, and Snail compared to IL-1beta. Melatonin 13-22 vimentin Homo sapiens 187-195 30861184-9 2019 Propofol treatment downregulated the protein levels of Vimentin, MMP-2, and MMP-9 while increasing that of E-cadherin. Propofol 0-8 vimentin Homo sapiens 55-63 31044454-12 2019 HCC cells treated with the miR-140-3p mimic or siRNA-GRN exhibited decreased GRN expression and downregulated the expressions of the MAPK signaling pathway-related genes, N-cadherin, and Vimentin but upregulated the expression of E-cadherin. mir-140-3p 27-37 vimentin Homo sapiens 187-195 31322227-4 2019 The results revealed that peritoneal mesothelial cells stimulated with UA underwent EMT, as demonstrated by the decreased expression of epithelial markers (E-cadherin) and an increased expression of mesenchymal markers (alpha-smooth muscle actin and vimentin). Uric Acid 71-73 vimentin Homo sapiens 250-258 31452821-7 2019 By contrast, artemisinin decreased proliferative capacity, decreased migration, decreased vimentin expression and increased E-cadherin expression of EMT model cells, indicating that MET was induced. artemisinin 13-24 vimentin Homo sapiens 90-98 31894675-5 2019 RESULTS: DHM concentration-dependently inhibited cell migration and invasion and downregulated matrix metalloprotein -2 (MMP-2) and phosphorylated JNK (pJNK) expression in MKN45 cells, followed by upregulation of E-cadherin and downregulation of Vimentin. dihydromyricetin 9-12 vimentin Homo sapiens 246-254 31511210-6 2019 In the two glioma cell lines, curcumin significantly suppressed the invasion and migration of the cells (P &lt; 0.05) and lowered the expressions of hepatoma-derived growth factor (HDGF), Ncadherin, vimentin, Snail and Slug, but increased the expression of E-cadherin. Curcumin 30-38 vimentin Homo sapiens 203-211 31238027-5 2019 Menadione suppressed invasion, migration and epithelial-mesenchymal transition in human CRC cells by upregulating the expression of E-cadherin (CDH1), ZO-1 and downregulating that of N-cadherin (CDH2), Vimentin (VIM), ZEB1, MMP2 and MMP9. Vitamin K 3 0-9 vimentin Homo sapiens 202-210 31238027-5 2019 Menadione suppressed invasion, migration and epithelial-mesenchymal transition in human CRC cells by upregulating the expression of E-cadherin (CDH1), ZO-1 and downregulating that of N-cadherin (CDH2), Vimentin (VIM), ZEB1, MMP2 and MMP9. Vitamin K 3 0-9 vimentin Homo sapiens 212-215 31002892-5 2019 In vitro assays showed that the co-culture of TAMs promoted the metastatic potential in HTB-1 and T24 by up-regulating EMT markers including Snail, VEGF and Vimentin, as well as oncogenic markers such as beta-catenin and NF-kappaB. tams 46-50 vimentin Homo sapiens 157-165 31405071-5 2019 EGCG prevented "Cadherin switch" and decreased the expression level of TCF8/ZEB1, beta-Catenin, and Vimentin. epigallocatechin gallate 0-4 vimentin Homo sapiens 100-108 30982493-7 2019 Overexpression of miR-148-3p or inhibition of DNMT1 induced the expression of E-cadherin and reduced the expressions of N-cadherin, vimentin, MMP-2, and MMP-9. mir-148-3p 18-28 vimentin Homo sapiens 132-140 31496729-10 2019 Oxymatrine significantly inhibited cell migration and invasion, downregulated the expression of N-cadherin, vimentin, and Snail in MDA-MB-231 and 4T1 cells, but upregulated the expression of E-cadherin in 4T1 cells. oxymatrine 0-10 vimentin Homo sapiens 108-116 31262517-6 2019 We also suggest that the oxymatrine reduces the metastatic potential by inhibition of the EMT process, as A549 cells treated with chosen doses of the compound were characterized by a decrease in the expression of the N-cadherin, vimentin and the elevation of E-cadherin level. oxymatrine 25-35 vimentin Homo sapiens 229-237 31389603-7 2019 After the inhibition of miR-9, the expression level of epithelial indicator CDH1 was increased, while that of interstitial indicator Vimentin was decreased. mir-9 24-29 vimentin Homo sapiens 133-141 31409969-6 2019 Results: The in vitro results showed that PL inhibited the proliferation of EMT model cells, increased the apoptosis rate of the EMT model, and significantly decreased the vimentin, PARP-1, N-cadherin and snail protein levels, but significantly increased E-cadherin and caspase-3 protein expression. plumbagin 42-44 vimentin Homo sapiens 172-180 31404982-7 2019 EGCG treatment resulted in enhancement of the SCUBE2 gene, along with elevated E-cadherin and decreased vimentin expression, leading to significant suppression of cell migration and invasion. epigallocatechin gallate 0-4 vimentin Homo sapiens 104-112 31559132-0 2019 Hypotonic Stress Induces Fast, Reversible Degradation of the Vimentin Cytoskeleton via Intracellular Calcium Release. Calcium 101-108 vimentin Homo sapiens 61-69 31559132-4 2019 In combination with calcium imaging and biochemical analysis, it is shown that the vimentin-specific fast cytoskeletal degradation under hypotonic stress is due to proteolysis by the calcium-dependent protease calpain. Calcium 20-27 vimentin Homo sapiens 83-91 31559132-4 2019 In combination with calcium imaging and biochemical analysis, it is shown that the vimentin-specific fast cytoskeletal degradation under hypotonic stress is due to proteolysis by the calcium-dependent protease calpain. Calcium 183-190 vimentin Homo sapiens 83-91 31559132-6 2019 Together, these findings highlight an unexpected, fast degradation mechanism for the vimentin cytoskeleton in response to external stimuli, and point to the significant, yet previously overlooked physiological impacts of hypotonic stress-induced intracellular calcium release on cell ultrastructure and function. Calcium 260-267 vimentin Homo sapiens 85-93 30169554-9 2019 Connexin hemichannels and ATP release from vimentin-positive glial cells may underlie spontaneous plateau depolarizations in the developing mammalian cortex. Adenosine Triphosphate 26-29 vimentin Homo sapiens 43-51 31409969-8 2019 Conclusion: PL may induce apoptosis of human hepatocellular carcinoma cells undergoing epithelial-mesenchymal transition by increasing the caspase-3 protein level and cleaving vimentin. plumbagin 12-14 vimentin Homo sapiens 176-184 31286874-8 2019 Activated c-Src phosphorylated E-cadherin at the tyrosine 797 site to initiate RNF43-mediated E-cadherin ubiquitination at lysine 816 and subsequent degradation, thus allowing the nuclear translocation of beta-catenin and upregulation of Vimentin and RNF43 expression in lung adenocarcinoma cells. Tyrosine 49-57 vimentin Homo sapiens 238-246 31286874-8 2019 Activated c-Src phosphorylated E-cadherin at the tyrosine 797 site to initiate RNF43-mediated E-cadherin ubiquitination at lysine 816 and subsequent degradation, thus allowing the nuclear translocation of beta-catenin and upregulation of Vimentin and RNF43 expression in lung adenocarcinoma cells. Lysine 123-129 vimentin Homo sapiens 238-246 31071512-8 2019 We report that amiodarone promoted cell proliferation and collagen I secretion, induced alpha-SMA and vimentin protein and mRNA expression accompanied by increased phosphorylation of ERK1/2 and p38 MAPK, and furthermore, PD98059 and SB203580 remarkably reduced the proliferative response of HELFs compared with amiodarone group and greatly attenuated alpha-SMA, vimentin and collagen I protein production induced by amiodarone. Amiodarone 15-25 vimentin Homo sapiens 102-110 30894331-9 2019 The locations of the ablated region and active DBS contact corresponded well with the segmented Vim nucleus. dibromsalan 47-50 vimentin Homo sapiens 96-99 31071512-8 2019 We report that amiodarone promoted cell proliferation and collagen I secretion, induced alpha-SMA and vimentin protein and mRNA expression accompanied by increased phosphorylation of ERK1/2 and p38 MAPK, and furthermore, PD98059 and SB203580 remarkably reduced the proliferative response of HELFs compared with amiodarone group and greatly attenuated alpha-SMA, vimentin and collagen I protein production induced by amiodarone. Amiodarone 15-25 vimentin Homo sapiens 362-370 31353834-7 2019 Like the linear relationship between V O2 and work rate in CE CPET, V O2 increased linearly with TM VIM. Oxygen 76-78 vimentin Homo sapiens 106-109 30905814-4 2019 Vimentin+ CTCs were detected in 76% of patients with PDAC (76/100) using CTCs enriched via a microfluidic assay. pdac 53-57 vimentin Homo sapiens 0-8 31003765-6 2019 We explored migration ability and the expression of the epithelial to mesenchymal transition (EMT)-related biomarkers E-cadherin, N-cadherin and Vimentin by silencing MEG3 under arsenic trioxide treatment. meg3 167-171 vimentin Homo sapiens 145-153 31003765-6 2019 We explored migration ability and the expression of the epithelial to mesenchymal transition (EMT)-related biomarkers E-cadherin, N-cadherin and Vimentin by silencing MEG3 under arsenic trioxide treatment. Arsenic Trioxide 178-194 vimentin Homo sapiens 145-153 31005252-8 2019 circP4HB promoted EMT and vimentin expression in vitro and xenograft metastasis in vivo through sequestration of miR-133a-5p. circp4hb 0-8 vimentin Homo sapiens 26-34 31197132-6 2019 Moreover, by cell sorting experiment, we have observed the expression of Vimentin in early apoptotic cells (AnnexinV positive) from 36 to 48 h of CPT treatment. cpt 146-149 vimentin Homo sapiens 73-81 30244296-8 2019 Additionally, PON administration also dramatically altered the expression of EMT-associated markers such as E-cadherin, N-cadherin, and Vimentin, and suppressed the expression of p-AKT, p-GSK-3beta and transcription factor, Snail in a dose-dependent manner. ponicidin 14-17 vimentin Homo sapiens 136-144 30716501-10 2019 CONCLUSIONS: Histopathology and immunohistochemical staining (characterized by positive expression of mainly STAT6 but also CD34, Bcl-2 protein, and vimentin) are key in diagnosis and management of ISFTs. isfts 198-203 vimentin Homo sapiens 149-157 31186039-11 2019 Notably, our studies revealed the mechanism that Ilamycin C can induce Bax/Bcl-2-related caspase-dependent apoptosis and inhibit migration and invasion through MMP2/MMP9/vimentin/fascin in TNBC by suppressing IL-6-induced STAT3 phosphorylation. ilamycin c 49-59 vimentin Homo sapiens 170-178 31219457-28 2019 The authors use a 15N-labelled vimentin domain and acquire a 2D spectrum using heteronuclear single quantum correlation (HSQC). 15n 18-21 vimentin Homo sapiens 31-39 31281396-9 2019 (3) UA significantly decreased the expressions of N-Cadherin, Vimentin, Snail, Twist p-Axl, p-IKKalpha/beta, and p-NF-kappaB in BGC-823 and MGC-803 cells. ursolic acid 4-6 vimentin Homo sapiens 62-70 30965237-5 2019 beta-Elemene also regulates the expression of several key molecules that are involved in tumor angiogenesis and metastasis including vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs), E-cadherin, N-cadherin, and vimentin. beta-elemene 0-12 vimentin Homo sapiens 238-246 29594833-6 2019 The immunohistochemical staining pattern was consistent with PAC, as the tumor cells showed diffuse positivity for cytokeratin, vimentin and S-100, and focal positivity for bcl-2, alpha-SMA and EMA. pac 61-64 vimentin Homo sapiens 128-136 30341909-4 2019 Our results demonstrated that treatment with newly synthesized 2-(3-hydroxyphenyl)-5-methylnaphthyridin-4-one (CSC-3436), a flavonoid derivative, elicited changes in its cell morphology, upregulated E-cadherin messenger RNA and protein expression, downregulated N-cadherin, vimentin, and CD133 (a marker associated with tumor-initiating cells) in FaDu-pCDH-Twist cells. 2-(3-hydroxyphenyl)-5-methylnaphthyridin-4-one 63-109 vimentin Homo sapiens 274-282 30341909-4 2019 Our results demonstrated that treatment with newly synthesized 2-(3-hydroxyphenyl)-5-methylnaphthyridin-4-one (CSC-3436), a flavonoid derivative, elicited changes in its cell morphology, upregulated E-cadherin messenger RNA and protein expression, downregulated N-cadherin, vimentin, and CD133 (a marker associated with tumor-initiating cells) in FaDu-pCDH-Twist cells. csc-3436 111-119 vimentin Homo sapiens 274-282 30341909-4 2019 Our results demonstrated that treatment with newly synthesized 2-(3-hydroxyphenyl)-5-methylnaphthyridin-4-one (CSC-3436), a flavonoid derivative, elicited changes in its cell morphology, upregulated E-cadherin messenger RNA and protein expression, downregulated N-cadherin, vimentin, and CD133 (a marker associated with tumor-initiating cells) in FaDu-pCDH-Twist cells. Flavonoids 124-133 vimentin Homo sapiens 274-282 29731224-6 2019 The results demonstrated that Farrerol treatment led to the downregulation of Slug and Zeb-1, transcriptional regulators of EMT with the concomitant increase and decrease in the expression of E-cadherin and vimentin respectively. farrerol 30-38 vimentin Homo sapiens 207-215 31186697-6 2019 In conclusion, in non-squamous NSCLC with downregulated E-cadherin and upregulated vimentin, the efficacy of chemotherapy with PGB was superior compared with EB; but the same effect was not observed in patients with high E-cadherin and low vimentin. Prostaglandins B 127-130 vimentin Homo sapiens 83-91 31186697-6 2019 In conclusion, in non-squamous NSCLC with downregulated E-cadherin and upregulated vimentin, the efficacy of chemotherapy with PGB was superior compared with EB; but the same effect was not observed in patients with high E-cadherin and low vimentin. Prostaglandins B 127-130 vimentin Homo sapiens 240-248 31137656-7 2019 Actinomycin V up-regulated both of the protein and mRNA expression levels of E-cadherin and down-regulated that of N-cadherin and vimentin in the same cells. ACTINOMYCIN V 0-13 vimentin Homo sapiens 130-138 32542091-9 2020 Moreover, miR-376c-3p mimic downregulated expression of N-cadherin and vimentin but upregulated that of E-cadherin and ZO-1 in MZ-CRC-1 cells. mir-376c-3p 10-21 vimentin Homo sapiens 71-79 31092810-8 2019 Doxorubicin-treated HeLa cells were stained with Vimentin antibody and sorted by flow cytometry. Doxorubicin 0-11 vimentin Homo sapiens 49-57 31005252-9 2019 CONCLUSION: circP4HB enhances EMT and metastatic disease through miR-133a-5p sequestration, leading to upregulation of vimentin. circp4hb 12-20 vimentin Homo sapiens 119-127 31133961-7 2019 After adjusting for confounders including mean TC level and comparing the highest and lowest TC-VIM quartiles, the hazard ratios (HRs) for all-cause dementia and AD were 1.15 [95% confidence interval (CI) = 1.05-1.27; P = 0.003] and 1.12 (95% CI = 1.00-1.25; P = 0.040), respectively. Technetium 93-95 vimentin Homo sapiens 96-99 31005718-12 2019 Moreover, curcumin down-regulated the mRNA expression of Vimentin, Fibronectin, and beta-catenin, and up-regulated E-cadherin mRNA expression levels. Curcumin 10-18 vimentin Homo sapiens 57-65 31151763-7 2019 Treatment with the mTOR signaling pathway inhibitor, rapamycin, inhibited the phosphorylation of mTOR and AKT, decreased Snail and Vimentin protein levels, and increased VE-cad protein levels. Sirolimus 53-62 vimentin Homo sapiens 131-139 30896826-10 2019 Furthermore, in the in vitro and in vivo experiments, songorine consistently downregulated the expression of N-cadherin, vimentin, matrix metalloproteinase (MMP)-2, MMP-9, phosphorylated-GSK3beta, beta-catenin and Bcl-2, and upregulated the expression of E-cadherin, cleaved caspase-3, cleaved caspase-9 and Bax. songorine 54-63 vimentin Homo sapiens 121-129 31017966-8 2019 These relationships were consistent with TC variability defined using TC-SD or TC-VIM. Technetium 41-43 vimentin Homo sapiens 82-85 31000696-5 2019 Baicalein also suppressed FN-induced downregulation of the epithelial markers E-cadherin and ZO-1 and upregulation of the mesenchymal markers N-cadherin, vimentin, and Snail. baicalein 0-9 vimentin Homo sapiens 154-162 30352165-6 2019 Furthermore, we demonstrated that lnc-ATB knockdown decreased ZEB1, ZEB2, N-cadherin, and vimentin expression, and promoted E-cadherin expression, while miR-141-3p inhibitor could reverse those effects. lnc-atb 34-41 vimentin Homo sapiens 90-98 30514595-0 2019 Killing activity of meropenem in combination with amikacin against VIM- or KPC-producing Enterobacteriaceae that are susceptible, intermediate, or resistant to amikacin. Meropenem 20-29 vimentin Homo sapiens 67-70 30514595-0 2019 Killing activity of meropenem in combination with amikacin against VIM- or KPC-producing Enterobacteriaceae that are susceptible, intermediate, or resistant to amikacin. Amikacin 50-58 vimentin Homo sapiens 67-70 30901662-12 2019 Moreover, chrysotobibenzyl was shown to suppress EMT indicated by the reduction of EMT markers (Vimentin, Snail, and Slug), and sensitize lung cancer cells to cisplatin-mediated apoptosis. Chrysotobibenzyl 10-26 vimentin Homo sapiens 96-104 30658903-0 2019 Vimentin disruption by lipoxidation and electrophiles: Role of the cysteine residue and filament dynamics. Cysteine 67-75 vimentin Homo sapiens 0-8 30658903-3 2019 In vitro, electrophilic lipids, including 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and 4-hydroxynonenal (HNE), directly bind to vimentin, whereas the oxidant diamide induces disulfide bond formation. 14-prostaglandin j2 59-78 vimentin Homo sapiens 135-143 30658903-3 2019 In vitro, electrophilic lipids, including 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and 4-hydroxynonenal (HNE), directly bind to vimentin, whereas the oxidant diamide induces disulfide bond formation. 15-deoxy-delta(12,14)-prostaglandin J2 80-88 vimentin Homo sapiens 135-143 30658903-3 2019 In vitro, electrophilic lipids, including 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and 4-hydroxynonenal (HNE), directly bind to vimentin, whereas the oxidant diamide induces disulfide bond formation. 4-hydroxy-2-nonenal 94-110 vimentin Homo sapiens 135-143 30658903-3 2019 In vitro, electrophilic lipids, including 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and 4-hydroxynonenal (HNE), directly bind to vimentin, whereas the oxidant diamide induces disulfide bond formation. 4-hydroxy-2-nonenal 112-115 vimentin Homo sapiens 135-143 30658903-3 2019 In vitro, electrophilic lipids, including 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and 4-hydroxynonenal (HNE), directly bind to vimentin, whereas the oxidant diamide induces disulfide bond formation. Diamide 165-172 vimentin Homo sapiens 135-143 30658903-3 2019 In vitro, electrophilic lipids, including 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and 4-hydroxynonenal (HNE), directly bind to vimentin, whereas the oxidant diamide induces disulfide bond formation. Disulfides 181-190 vimentin Homo sapiens 135-143 30658903-4 2019 Mutation of the single vimentin cysteine residue (Cys328) blunts disulfide formation and reduces lipoxidation by 15d-PGJ2, but not HNE. Cysteine 32-40 vimentin Homo sapiens 23-31 30658903-4 2019 Mutation of the single vimentin cysteine residue (Cys328) blunts disulfide formation and reduces lipoxidation by 15d-PGJ2, but not HNE. Disulfides 65-74 vimentin Homo sapiens 23-31 30658903-4 2019 Mutation of the single vimentin cysteine residue (Cys328) blunts disulfide formation and reduces lipoxidation by 15d-PGJ2, but not HNE. 15-deoxy-delta(12,14)-prostaglandin J2 113-121 vimentin Homo sapiens 23-31 30658903-5 2019 Preincubation with these agents differentially hinders NaCl-induced filament formation by wild-type vimentin, with effects ranging from delayed elongation and increased filament diameter to severe impairment of assembly or aggregation. Sodium Chloride 55-59 vimentin Homo sapiens 100-108 30658903-9 2019 As the cellular vimentin network is under continuous remodeling, we hypothesized that vimentin exchange on filaments would be necessary for diamide-induced disruption. Diamide 140-147 vimentin Homo sapiens 16-24 30658903-9 2019 As the cellular vimentin network is under continuous remodeling, we hypothesized that vimentin exchange on filaments would be necessary for diamide-induced disruption. Diamide 140-147 vimentin Homo sapiens 86-94 30658903-10 2019 We confirmed that strategies reducing vimentin dynamics, as monitored by FRAP, including cysteine crosslinking and ATP synthesis inhibition, prevent diamide effect. Cysteine 89-97 vimentin Homo sapiens 38-46 30658903-10 2019 We confirmed that strategies reducing vimentin dynamics, as monitored by FRAP, including cysteine crosslinking and ATP synthesis inhibition, prevent diamide effect. Adenosine Triphosphate 115-118 vimentin Homo sapiens 38-46 30658903-10 2019 We confirmed that strategies reducing vimentin dynamics, as monitored by FRAP, including cysteine crosslinking and ATP synthesis inhibition, prevent diamide effect. Diamide 149-156 vimentin Homo sapiens 38-46 30658903-12 2019 Indeed, treatment with the phosphatase inhibitor calyculin A to prevent dephosphorylation intensifies electrophile-induced wild-type vimentin filament disruption. calyculin A 49-60 vimentin Homo sapiens 133-141 30987208-6 2019 Western blotting showed that treatment with LiCl or small molecule GSK-3 inhibitors led to the rapid downregulation of detergent soluble vimentin levels across a panel of GBM-derived cells. Lithium Chloride 44-48 vimentin Homo sapiens 137-145 30987208-7 2019 Fluorescence reactivation after photobleaching (FRAP) microscopy studies showed a significant reduction in the ability of the vimentin cytoskeleton to recover from photo-bleaching in the presence of LiCl or BIO. Lithium Chloride 199-203 vimentin Homo sapiens 126-134 30784907-7 2019 Results Sinomenine significantly suppressed cell proliferation, promoted apoptosis and inhibited migration and invasion, as well as down-regulated Cyclin D1, CDK4, Bcl-2, MMP-2, MMP-9, Vimentin protein levels and up-regulated p16 and Bax protein levels in PC3 cells. sinomenine 8-18 vimentin Homo sapiens 185-193 30822424-9 2019 Meanwhile, down-regulation of Cyclin D1, MMP-2 and Vimentin, up-regulations of p53 and p21, as well as cleavage of caspase-3 and -9 were observed in Salidroside-treated cell. rhodioloside 149-160 vimentin Homo sapiens 51-59 30317672-8 2019 Meanwhile, E-cadherin was remarkably downregulated, and N-cadherin, Vimentin, ZEB1, and Snail were upregulated by miR-105 overexpression. mir-105 114-121 vimentin Homo sapiens 68-76 30678934-9 2019 Moreover, molecular mechanism-based studies revealed that BZ6-ONPs downregulated AKT/NF-kappaB/vimentin/survivin-mediated oncogenic signaling pathway promoting cell proliferation and malignancy. 4-(imidazol-1-ylmethyl)-3-(4-methoxyphenyl)-1-phenyl-pyrazole 58-61 vimentin Homo sapiens 95-103 30925160-0 2019 Phosphorylation of a serine/proline-rich motif in oxysterol binding protein-related protein 4L (ORP4L) regulates cholesterol and vimentin binding. Serine 21-27 vimentin Homo sapiens 129-137 30925160-0 2019 Phosphorylation of a serine/proline-rich motif in oxysterol binding protein-related protein 4L (ORP4L) regulates cholesterol and vimentin binding. Proline 28-35 vimentin Homo sapiens 129-137 30925160-9 2019 We conclude that phosphorylation of a unique serine/proline motif in the ORD induces a conformation change in ORP4L that enhances interaction with vimentin and cholesterol extraction from membranes. Serine 45-51 vimentin Homo sapiens 147-155 30925160-9 2019 We conclude that phosphorylation of a unique serine/proline motif in the ORD induces a conformation change in ORP4L that enhances interaction with vimentin and cholesterol extraction from membranes. Proline 52-59 vimentin Homo sapiens 147-155 30902084-9 2019 TSA stimulation for 48 h could effectively induce the EMT in CNE2 and C666-1 cells, which showed an increase of spindle-like cells and promoted expression of Vimentin and Snail1 expression in a concentration-dependent manner. trichostatin A 0-3 vimentin Homo sapiens 158-166 30894168-0 2019 The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells. ajoene 20-26 vimentin Homo sapiens 44-52 30901941-8 2019 Immunofluorescence assays confirmed that resveratrol changed the expression of the EMT-related markers E-cadherin and vimentin. Resveratrol 41-52 vimentin Homo sapiens 118-126 30901941-9 2019 Western blot analysis demonstrated that resveratrol decreased the expression levels of MMP-2, MMP-9, Fibronectin, alpha-SMA, P-PI3K, P-AKT, Smad2, Smad3, P-Smad2, P-Smad3, vimentin, Snail1, and Slug, as well as increased the expression levels of E-cadherin in MDA231 cells. Resveratrol 40-51 vimentin Homo sapiens 172-180 30894168-0 2019 The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells. ajoene 20-26 vimentin Homo sapiens 67-75 30894168-6 2019 Computational modelling of vimentin bound to ajoene was performed using Schrodinger and pKa calculations by Epik software. ajoene 45-51 vimentin Homo sapiens 27-35 30894168-8 2019 The vimentin filament network was visualised in ajoene-treated and non-treated cells by immunofluorescence and vimentin protein expression was determined by immunoblot. ajoene 48-54 vimentin Homo sapiens 4-12 30894168-10 2019 RESULTS: The dominant protein tagged by dansyl-ajoene was identified to be the 57 kDa protein vimentin. dansyl-ajoene 40-53 vimentin Homo sapiens 94-102 30894168-11 2019 The vimentin target was validated to reveal that ajoene and dansyl-ajoene covalently bind to recombinant vimentin via a disulfide linkage at Cys-328. ajoene 49-55 vimentin Homo sapiens 4-12 30894168-11 2019 The vimentin target was validated to reveal that ajoene and dansyl-ajoene covalently bind to recombinant vimentin via a disulfide linkage at Cys-328. ajoene 49-55 vimentin Homo sapiens 105-113 30894168-11 2019 The vimentin target was validated to reveal that ajoene and dansyl-ajoene covalently bind to recombinant vimentin via a disulfide linkage at Cys-328. dansyl-ajoene 60-73 vimentin Homo sapiens 4-12 30894168-11 2019 The vimentin target was validated to reveal that ajoene and dansyl-ajoene covalently bind to recombinant vimentin via a disulfide linkage at Cys-328. dansyl-ajoene 60-73 vimentin Homo sapiens 105-113 30894168-11 2019 The vimentin target was validated to reveal that ajoene and dansyl-ajoene covalently bind to recombinant vimentin via a disulfide linkage at Cys-328. Disulfides 120-129 vimentin Homo sapiens 4-12 30894168-11 2019 The vimentin target was validated to reveal that ajoene and dansyl-ajoene covalently bind to recombinant vimentin via a disulfide linkage at Cys-328. Disulfides 120-129 vimentin Homo sapiens 105-113 30894168-11 2019 The vimentin target was validated to reveal that ajoene and dansyl-ajoene covalently bind to recombinant vimentin via a disulfide linkage at Cys-328. Cysteine 141-144 vimentin Homo sapiens 4-12 30894168-11 2019 The vimentin target was validated to reveal that ajoene and dansyl-ajoene covalently bind to recombinant vimentin via a disulfide linkage at Cys-328. Cysteine 141-144 vimentin Homo sapiens 105-113 30894168-12 2019 Computational modelling showed Cys-328 to be exposed at the termini of the vimentin tetramer. Cysteine 31-34 vimentin Homo sapiens 75-83 30894168-13 2019 Treatment of MDA-MB-231 or HeLa cells with a non-cytotoxic concentration of ajoene caused the vimentin filament network to condense; and to increase vimentin protein expression. ajoene 76-82 vimentin Homo sapiens 94-102 30894168-13 2019 Treatment of MDA-MB-231 or HeLa cells with a non-cytotoxic concentration of ajoene caused the vimentin filament network to condense; and to increase vimentin protein expression. ajoene 76-82 vimentin Homo sapiens 149-157 30894168-14 2019 Ajoene inhibited the invasion and migration of both cancer cell lines which was found to be dependent on the presence of vimentin. ajoene 0-6 vimentin Homo sapiens 121-129 30894168-15 2019 Vimentin overexpression caused cells to become more migratory, an effect that was completely rescued by ajoene. ajoene 104-110 vimentin Homo sapiens 0-8 30894168-16 2019 CONCLUSIONS: The garlic-derived phytochemical ajoene targets and covalently modifies vimentin in cancer cells by S-thiolating Cys-328. ajoene 46-52 vimentin Homo sapiens 85-93 30894168-16 2019 CONCLUSIONS: The garlic-derived phytochemical ajoene targets and covalently modifies vimentin in cancer cells by S-thiolating Cys-328. Cysteine 126-129 vimentin Homo sapiens 85-93 30894168-17 2019 This interaction results in the disruption of the vimentin filament network and contributes to the anti-metastatic activity of ajoene in cancer cells. ajoene 127-133 vimentin Homo sapiens 50-58 30890138-9 2019 Additionally, Swainsonine impeded the abilities of migration and invasion by decreasing MMP-2, MMP-9, Vimentin and E-cadherin. Swainsonine 14-25 vimentin Homo sapiens 102-110 30893730-13 2019 The results of Western blot showed that the protein relative expression of vimentin of the control group and the PFOA (50 mumol/L) group were 0.55+-0.06 and 0.81+-0.01 respectively, and there was a significant difference (t=4.50, P<0.05). 3-O-(N-(p-fluorobenzenesulfonyl)carbamoyl)oleanolic acid 113-117 vimentin Homo sapiens 75-83 30875964-7 2019 In addition, the Golgi complex and vimentin were involved in Nic-induced NCLL, which might be a platform or membrane source for Nic-induced LC3-positive structures. Niclosamide 61-64 vimentin Homo sapiens 35-43 30915272-5 2019 Methods: Co-expression of CK8 and Vim was evaluated by immunofluorescence (IF) on paraffin-embedded tissue sections of 122 patients with PCa who underwent radical prostatectomies between 1998 and 2016 at the American University of Beirut Medical Center (AUBMC). Paraffin 82-90 vimentin Homo sapiens 34-37 30915272-7 2019 Results: The co-expression of CK8/Vim (EMT score), was associated with increasing Gleason group. gleason 82-89 vimentin Homo sapiens 34-37 30893730-15 2019 Conclusions: Low dose PFOA (50 mumol/L) exposure promotes cell proliferation, migration and invasion in the human muscle rhabdomyosarcoma cell line through inducing the expressions of MMP2, vimentin and cell cycle related genes. 3-O-(N-(p-fluorobenzenesulfonyl)carbamoyl)oleanolic acid 22-26 vimentin Homo sapiens 190-198 30773659-5 2019 We found that Y-27632 inhibited collagen gel contraction, as well as alpha-smooth muscle actin and vimentin expression; these were promoted by treatment with latanoprost, timolol, or transforming growth factor (TGF)-beta. Latanoprost 158-169 vimentin Homo sapiens 99-107 30773659-5 2019 We found that Y-27632 inhibited collagen gel contraction, as well as alpha-smooth muscle actin and vimentin expression; these were promoted by treatment with latanoprost, timolol, or transforming growth factor (TGF)-beta. Timolol 171-178 vimentin Homo sapiens 99-107 30949224-5 2019 Western blot analysis revealed that baicalein suppressed the expression of Id1 protein, epithelial-to-mesenchymal transition (EMT) related molecules (N-Cadherin, vimentin), and angiogenesis related protein (VEGF-A), accompanied by upregulation of epithelial markers (such as E-cadherin). baicalein 36-45 vimentin Homo sapiens 162-170 30265375-8 2019 Furthermore, exogenous NaHS significantly upregulated the expression of E-cadherin, whereas it downregulated the expression of vimentin. sodium bisulfide 23-27 vimentin Homo sapiens 127-135 30806631-8 2019 Moreover, the treatment of MDA-MB-231 cells with triorganotin compounds together with ATRA resulted in an additional reduction of annexin 5, vimentin and nucleoside diphosphate kinase B. triorganotin 49-61 vimentin Homo sapiens 141-149 30806631-8 2019 Moreover, the treatment of MDA-MB-231 cells with triorganotin compounds together with ATRA resulted in an additional reduction of annexin 5, vimentin and nucleoside diphosphate kinase B. Tretinoin 86-90 vimentin Homo sapiens 141-149 30628646-12 2019 The miR-150-5p inhibitor-induced increase in N-cadherin, and decrease in E-cadherin and vimentin was inhibited by FOXD2-AS1 knockdown. mir-150-5p 4-14 vimentin Homo sapiens 88-96 31933895-7 2019 RESULTS: Dioscin inhibited LPS-induced morphologic changes, significantly reduced the levels of markers of EMT including N-cadherin, matrix metalloproteinase-2 (MMP-2), MMP-9 and vimentin, and elevated the levels of E-cadherin and zonula occludens protein 1 (ZO-1). dioscin 9-16 vimentin Homo sapiens 179-187 30643918-9 2019 LX-2 cells, cultured in the media from arsenite-treated L-02 cells, showed elevated levels of proliferating cell nuclear antigen (PCNA), collagen I, vimentin, and alpha-smooth muscle actin (alpha-SMA), which indicated activation of these cells. arsenite 39-47 vimentin Homo sapiens 149-157 30606573-6 2019 Compared to keratin, the assembly of vimentin intermediate filaments were promoted by incorporating bovine serum albumin (BSA) functionalized graphene oxide (BSA-GO) into polycaprolactone (PCL) nanofibers. graphene oxide 142-156 vimentin Homo sapiens 37-45 30606573-6 2019 Compared to keratin, the assembly of vimentin intermediate filaments were promoted by incorporating bovine serum albumin (BSA) functionalized graphene oxide (BSA-GO) into polycaprolactone (PCL) nanofibers. polycaprolactone 171-187 vimentin Homo sapiens 37-45 30606573-6 2019 Compared to keratin, the assembly of vimentin intermediate filaments were promoted by incorporating bovine serum albumin (BSA) functionalized graphene oxide (BSA-GO) into polycaprolactone (PCL) nanofibers. polycaprolactone 189-192 vimentin Homo sapiens 37-45 30609598-1 2019 Poly(1-vinylimidazole-co-ethylene dimethacrylate) (VIM-EDMA) monolithic stationary phase was applied for separation of inorganic anions by capillary ion chromatography (IC). poly(1-vinylimidazole-co-ethylene dimethacrylate) 0-49 vimentin Homo sapiens 51-54 30609598-2 2019 The retention of inorganic anions on the VIM-EDMA column was investigated using various salt solutions as the eluent. EDMA 45-49 vimentin Homo sapiens 41-44 30609598-3 2019 Good separation of inorganic anions was obtained on VIM-EDMA monolithic column using NH4Cl as the eluent. EDMA 56-60 vimentin Homo sapiens 52-55 30609598-3 2019 Good separation of inorganic anions was obtained on VIM-EDMA monolithic column using NH4Cl as the eluent. Ammonium Chloride 85-90 vimentin Homo sapiens 52-55 30609598-6 2019 Relatively low RSDs (n = 7) of retention time (<2.3%) and peak area (<8.8%) were obtained on the VIM-EDMA column. EDMA 107-111 vimentin Homo sapiens 103-106 30609598-7 2019 The utilization of VIM-EDMA column for potential environmental application was also demonstrated by determining the occurrence of inorganic anions in various environmental water samples without sample preparation process. EDMA 23-27 vimentin Homo sapiens 19-22 30609598-7 2019 The utilization of VIM-EDMA column for potential environmental application was also demonstrated by determining the occurrence of inorganic anions in various environmental water samples without sample preparation process. Water 172-177 vimentin Homo sapiens 19-22 30543920-9 2019 Cit-ME-Vim levels were 0.55 +- 0.46 ODU in RA subjects and 0.17 +- 0.182 ODU in healthy controls whereas Cit-ME-Eno was 0.61 +- 0.65 ODU in RA subjects and 0.22 +- 0.20 ODU in healthy controls. cit-me 0-6 vimentin Homo sapiens 7-10 30345465-4 2019 Hybrid 13h could inhibit migration by regulating the expression level of N-cadherin, E-cadherin, Vimentin, and actived-MMP2. 13h 7-10 vimentin Homo sapiens 97-105 30615851-3 2019 HCC/Dox cells exhibited mesenchymal characteristics, which was evidenced by the up regulation of fibronectin, vimentin while down regulation of E-Cadherin. Doxorubicin 4-7 vimentin Homo sapiens 110-118 30569135-3 2019 Additionally, metformin attenuated the EMT process, characterized by a decrease of mesenchymal marker Vimentin and an increase in the expression of an epithelial marker. Metformin 14-23 vimentin Homo sapiens 102-110 32328567-3 2019 Contractile activation induces vimentin phosphorylation at Ser-56 and vimentin network reorientation, facilitating contractile force transmission among and within smooth muscle cells. Serine 59-62 vimentin Homo sapiens 31-39 32328567-4 2019 p21-activated kinase 1 and polo-like kinase 1 catalyze vimentin phosphorylation at Ser-56, whereas type 1 protein phosphatase dephosphorylates vimentin at this residue. Serine 83-86 vimentin Homo sapiens 55-63 30292839-2 2019 Our present data showed that an industrial endocrine disrupting chemical, bisphenol S (BPS), can promote the in vitro migration of NSCLC cells, which was evidenced by the upregulation of vimentin and matrix metalloproteinase-2 (MMP-2). bis(4-hydroxyphenyl)sulfone 74-85 vimentin Homo sapiens 187-195 30699149-2 2019 Here we report that inhibition of vimentin using the steroidal lactone Withaferin A (WFA) causes vimentin to aggregate, and this is associated with the relocalisation of organelles including autophagosomes and lysosomes from the cytosol to a juxtanuclear location. Lactones 63-70 vimentin Homo sapiens 34-42 30699149-2 2019 Here we report that inhibition of vimentin using the steroidal lactone Withaferin A (WFA) causes vimentin to aggregate, and this is associated with the relocalisation of organelles including autophagosomes and lysosomes from the cytosol to a juxtanuclear location. withaferin A 71-83 vimentin Homo sapiens 34-42 30699149-2 2019 Here we report that inhibition of vimentin using the steroidal lactone Withaferin A (WFA) causes vimentin to aggregate, and this is associated with the relocalisation of organelles including autophagosomes and lysosomes from the cytosol to a juxtanuclear location. withaferin A 71-83 vimentin Homo sapiens 97-105 30699149-2 2019 Here we report that inhibition of vimentin using the steroidal lactone Withaferin A (WFA) causes vimentin to aggregate, and this is associated with the relocalisation of organelles including autophagosomes and lysosomes from the cytosol to a juxtanuclear location. withaferin A 85-88 vimentin Homo sapiens 34-42 30699149-2 2019 Here we report that inhibition of vimentin using the steroidal lactone Withaferin A (WFA) causes vimentin to aggregate, and this is associated with the relocalisation of organelles including autophagosomes and lysosomes from the cytosol to a juxtanuclear location. withaferin A 85-88 vimentin Homo sapiens 97-105 30625181-6 2019 Similarly, metformin treatment suppressed expressions of anti-apoptotic genes BCL2 and Bcl-xL, and mesenchymal genes vimentin, N-cadherin, Zeb1 and Zeb2 with simultaneous enhancement of apoptotic caspase 3 and Bax, and epithelial genes E-cadherin and keratin 19 expressions, confirming an inhibitory effect of metformin in tumorigenesis. Metformin 11-20 vimentin Homo sapiens 117-125 30625181-9 2019 Similarly, cholesterol treatment inverted metformin-reduced several gene expressions (e.g., Bcl-xL, BCL2, Zeb1, vimentin, and BMI-1). Cholesterol 11-22 vimentin Homo sapiens 112-120 30387838-9 2019 miR-132 mimics also reduced DEX-induced clonogenicity, migration and expression of vimentin and E-cadherin in vitro and in tumor xenografts. Dexamethasone 28-31 vimentin Homo sapiens 83-91 30707744-0 2019 Retraction: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network. Serotonin 41-50 vimentin Homo sapiens 95-103 31215378-10 2019 Hyperglycemia promoted epithelial-mesenchymal transition (EMT), while mogroside V could reverse this process through up-regulating E-Cadherin expression and down-regulating N-Cadherin, Vimentin, Snail expressions. mogroside V 70-81 vimentin Homo sapiens 185-193 30625181-9 2019 Similarly, cholesterol treatment inverted metformin-reduced several gene expressions (e.g., Bcl-xL, BCL2, Zeb1, vimentin, and BMI-1). Metformin 42-51 vimentin Homo sapiens 112-120 30609805-6 2019 We explored EMT in human mesothelial cells (MeT-5A) exposed to chrysotile asbestos: we demonstrated that asbestos induces EMT in MeT-5A cells by downregulating epithelial markers E-cadherin, beta-catenin, and occludin, and contemporarily, by upregulating mesenchymal markers fibronectin, alpha-SMA, and vimentin, thus promoting EMT. Asbestos 74-82 vimentin Homo sapiens 303-311 30551506-9 2019 Moreover, ICA inhibited cell migration and invasion by down-regulating MMP-9 and Vimentin in SW579 and TPC1 cells (p < 0.01 or p < 0.001). icariin 10-13 vimentin Homo sapiens 81-89 31061311-4 2019 Additional experiments show that UA inhibits cell migration and epithelial-mesenchymal transition (EMT), including E-cadherin, Vimentin, Integrin, Twist, and Zeb1 biomakers. ursolic acid 33-35 vimentin Homo sapiens 127-135 30306430-5 2019 RESULTS: The status of vimentin and increasing labeling index (LI) of TopoIIalpha and KI67 in biopsy specimens were significantly associated with those who responded to NAC treatment. nac 169-172 vimentin Homo sapiens 23-31 30403907-5 2019 E-cadherin was not consistently affected but vimentin was induced by low serum-containing media and was increased by serine proteases in MCF-7 and MDA-MB-231 cells in parallel with increased wound closure. Serine 117-123 vimentin Homo sapiens 45-53 30161272-9 2019 miR-133a suppression accelerated transforming growth factor-beta1 (TGF-beta1)-induce EMT, as evidenced by upregulation of E-cadherin, and downregulation of N-cadherin, vimentin, and Slug. mir-133a 0-8 vimentin Homo sapiens 168-176 31939444-10 2019 Metformin attenuated transforming growth factor-beta1 induced decrease of E-cadherin and increase of Vimentin proteins. Metformin 0-9 vimentin Homo sapiens 101-109 30365046-10 2019 Immunofluorescence staining analysis demonstrated that vimentin, filamentous actin and zinc finger E-box-binding homeobox 1 were all decreased following treatment with Thiostrepton. Thiostrepton 168-180 vimentin Homo sapiens 55-63 30111817-3 2019 Here we report that NSCLC cells with acquired resistance to gefitinib or osimertinib (AZD9291) exhibit EMT features, with a decrease in E-cadherin, and increases in vimentin and stemness, without possessing any EGFR secondary mutations. Gefitinib 60-69 vimentin Homo sapiens 165-173 30111817-3 2019 Here we report that NSCLC cells with acquired resistance to gefitinib or osimertinib (AZD9291) exhibit EMT features, with a decrease in E-cadherin, and increases in vimentin and stemness, without possessing any EGFR secondary mutations. osimertinib 73-84 vimentin Homo sapiens 165-173 30111817-3 2019 Here we report that NSCLC cells with acquired resistance to gefitinib or osimertinib (AZD9291) exhibit EMT features, with a decrease in E-cadherin, and increases in vimentin and stemness, without possessing any EGFR secondary mutations. osimertinib 86-93 vimentin Homo sapiens 165-173 30111817-8 2019 The dual HDAC and HMGR inhibitor JMF3086 inhibited the Src/Hakai and Hakai/E-cadherin interaction to reverse E-cadherin expression, and attenuated vimentin and stemness to restore gefitinib sensitivity. jmf3086 33-40 vimentin Homo sapiens 147-155 30599896-10 2019 Interestingly, caffeic acid and rosmarinic acid were more potent in reducing E-cadherin and vimentin levels in TGF-beta1-induced BEAS-2B cells, and alpha-SMA and COL1A1 amounts in TGF-beta1-induced MRC-5 cells. caffeic acid 15-27 vimentin Homo sapiens 92-100 29402342-7 2018 Results showed that propofol suppressed A549 cell viability, migration, and invasion, upregulated E-cadherin, and downregulated N-cadherin, vimentin, and Snail expressions. Propofol 20-28 vimentin Homo sapiens 140-148 30243739-7 2018 Moreover, oridonin increased the protein expression of E-cadherin and decreased that of N-cadherin and Vimentin. oridonin 10-18 vimentin Homo sapiens 103-111 30243739-8 2018 Oridonin upregulated the transcription of E-cadherin and downregulated N-cadherin and Vimentin. oridonin 0-8 vimentin Homo sapiens 86-94 30243739-12 2018 Oridonin increased the protein expression of E-cadherin and reduced N-cadherin and Vimentin. oridonin 0-8 vimentin Homo sapiens 83-91 30266538-8 2018 Moreover, epithelial-mesenchymal transition (EMT) was inhibited in dictamnine-treated tumors by downregulation of HIF-1alpha and Slug, as reflected by the upregulation of E-cadherin and Occludin, and the downregulation of N-cadherin and Vimentin. dictamnine 67-77 vimentin Homo sapiens 237-245 30267961-4 2019 Treatment of cells with the vimentin-targeting steroidal lactone withaferin A had no effect on vimentin turnover as previously reported, instead causing NEDD9 cleavage and cell death. Lactones 57-64 vimentin Homo sapiens 28-36 30267961-4 2019 Treatment of cells with the vimentin-targeting steroidal lactone withaferin A had no effect on vimentin turnover as previously reported, instead causing NEDD9 cleavage and cell death. withaferin A 65-77 vimentin Homo sapiens 28-36 30563094-9 2018 Furthermore, 4-AAQB markedly reduced the viability of U87MG and DBTRG-05MG cells with 48 h IC50 of 9.2 M and 12.5 M, respectively, effectively inhibited the nuclear catenin, limited the migration and invasion of GBM cells, with concurrent downregulation of catenin, vimentin, and slug; similarly, colony and tumorsphere formation was significantly attenuated with reduced expression of c-Myc and KLF4 proteins. 4-acetylantroquinonol B 13-19 vimentin Homo sapiens 266-274 30563094-9 2018 Furthermore, 4-AAQB markedly reduced the viability of U87MG and DBTRG-05MG cells with 48 h IC50 of 9.2 M and 12.5 M, respectively, effectively inhibited the nuclear catenin, limited the migration and invasion of GBM cells, with concurrent downregulation of catenin, vimentin, and slug; similarly, colony and tumorsphere formation was significantly attenuated with reduced expression of c-Myc and KLF4 proteins. dbtrg 64-69 vimentin Homo sapiens 266-274 30603229-6 2018 Results: Unilateral tremor-scores with items 5-6 (tremor of the upper extremity), 8-9 (tremor of the lower extremity), and 11-14 (hand function) from the ETRS showed a 63% tremor reduction in the VIM group, 47% tremor reduction in the PSA group, and 67% tremor reduction in the intermediate group after a mean follow-up of 1.6 years. psa 235-238 vimentin Homo sapiens 196-199 30662803-7 2018 Mechanistically, SIRT5 was found to bind to and deacetylate vimentin at lysine 120. Lysine 72-78 vimentin Homo sapiens 60-68 30599896-10 2019 Interestingly, caffeic acid and rosmarinic acid were more potent in reducing E-cadherin and vimentin levels in TGF-beta1-induced BEAS-2B cells, and alpha-SMA and COL1A1 amounts in TGF-beta1-induced MRC-5 cells. rosmarinic acid 32-47 vimentin Homo sapiens 92-100 30464516-14 2018 Consistent with the findings, the expressions of pSrc, pFAK, FAK, vinculin, vimentin, and paxillin were all downregulated by CD. Cadmium 125-127 vimentin Homo sapiens 76-84 30504386-7 2018 Western blot analysis indicated that naringenin up-regulated E-cadherin expression, but down-regulated the expression of vimentin, SNAIL family zinc finger 1 (SNAI1), SNAIL family zinc finger 2 (SNAI2), and TWIST family bHLH transcription factor 1 (TWIST1). naringenin 37-47 vimentin Homo sapiens 121-129 30189187-7 2018 Further, upon BP treatment, vimentin expressing clones showed an increase in vitro and in vivo transformation efficiency. Benzo(a)pyrene 14-16 vimentin Homo sapiens 28-36 31949649-13 2018 Additionally, cell invasion was promoted by miR-106a-5p overexpression in the HT-29 cells and was inhibited by miR-106a-5p knockdown in the 5-FU resistant HT-29 cells; miR-106a-5p overexpression contributed to migration by increasing vimentin expression and by decreasing E-cadherin expression in the HT-29 cells; miR-106a-5p functioned by directly binding to TGFbetaR2. Fluorouracil 140-144 vimentin Homo sapiens 234-242 30272354-6 2018 The combination of capsaicin and sorafenib also inhibited cell invasion and metastasis via upregulation of E-cadherin and downregulation of N-cadherin, vimentin, matrix metalloproteinase (MMP)2 and MMP9. Capsaicin 19-28 vimentin Homo sapiens 152-160 30272354-6 2018 The combination of capsaicin and sorafenib also inhibited cell invasion and metastasis via upregulation of E-cadherin and downregulation of N-cadherin, vimentin, matrix metalloproteinase (MMP)2 and MMP9. Sorafenib 33-42 vimentin Homo sapiens 152-160 30270026-8 2018 Vimentin was neo-expressed in 65% of poorly differentiated ePSCC at the IF indicating EMT. neo 13-16 vimentin Homo sapiens 0-8 30598637-8 2018 Therefore, by using the specific TGF-beta receptor 1 inhibitor SB-431542 in healthy SGEC treated with TGF-beta1, we showed a significant reduction of the fibrosis markers vimentin and collagen type I while the epithelial marker E-cadherin returns to levels similar to untreated healthy SGEC. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 63-72 vimentin Homo sapiens 171-179 30637283-1 2018 Background: DBS in the ventral intermediate nucleus (VIM) of the thalamus has been a revolutionary treatment for patients with essential tremor (ET) by reducing tremor. dibromsalan 12-15 vimentin Homo sapiens 53-56 30637283-5 2018 Methods: This was a randomized, placebo-controlled trial for patients with VIM DBS for ET. dibromsalan 79-82 vimentin Homo sapiens 75-78 30637283-11 2018 Conclusion: Alternating stimulation patterns on a weekly basis for ET patients with VIM DBS reduced habituation in this pilot study. dibromsalan 88-91 vimentin Homo sapiens 84-87 30403199-10 2018 Additionally, the level of PQ-induced E-cadherin was decreased by An while the expressions of vimentin, alpha-smooth muscle actin (alpha-SMA), and collagens type I (col-I) were increased. Paraquat 27-29 vimentin Homo sapiens 94-102 29923216-8 2018 Furthermore, the migrative and invasive capabilities of renal cancer cells were markedly repressed by BA treatment, which was related to upregulation of matrix metalloproteinase (MMP)2, MMP9, and vimentin, and downregulation of tissue inhibitor of metalloproteinase 2 and E-cadherin. betulinic acid 102-104 vimentin Homo sapiens 196-204 29442266-6 2018 Moreover, significant enhancement VIM expression was detected in the presence of D-Kyn (10 and 40 microM). D-Kynurenine 81-86 vimentin Homo sapiens 34-37 29442266-8 2018 Additionally, 10 microM D-Kyn-mediated changes of VIM and E-cadherin were substantially attenuated on siRNAAhr treatment as well. D-Kynurenine 24-29 vimentin Homo sapiens 50-53 30693839-8 2018 CML-BSA increased the protein levels of mesenchymal-specific markers, including vimentin, alpha-smooth muscle actin, which were alleviated by pre-treatment with alpha-lipoic acid. Thioctic Acid 161-178 vimentin Homo sapiens 80-88 30136444-9 2018 Furthermore, 2HF decreased expression of Ki67, CD31, vimentin, inhibited phosphorylation of Akt and expression of survivin and Bcl2, and increased levels of Bax, E-cadherin, and cleaved-PARP. 2'-hydroxyflavanone 13-16 vimentin Homo sapiens 53-61 30546461-6 2018 The results of the present study also revealed that FK866 led to a decrease in the expression of SIRT1, and to increased and decreased levels of the EMT marker proteins epithelial cadherin and vimentin, respectively, in MHCC97-H cells. N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 52-57 vimentin Homo sapiens 193-201 30195041-8 2018 Besides, alpha-mangostin significantly reduced cell re-adhesion and migration, matrix metalloproteinases-2 (MMP-2) and MMP-9 secretions, and EMT-involved protein (N-cadherin, alphaV, beta1 integrin, and vimentin) expressions. mangostin 9-24 vimentin Homo sapiens 203-211 30643062-5 2018 However, after ursolic acid treatment, the migration and invasion ability were significantly reduced, and the expression of E-cadherin was increased while N-cadherin and vimentin levels were decreased. ursolic acid 15-27 vimentin Homo sapiens 170-178 30451240-5 2018 A two-dimensional NMR spectrum is acquired to detect interactions by observing changes in peak shape or chemical shifts, and to elucidate effects of solution conditions including salt levels, which influence vimentin quaternary structure. Salts 179-183 vimentin Homo sapiens 208-216 30396956-8 2018 In transforming growth factor-beta-treated cells, evodiamine attenuated variations in morphology, growth and migration, and increased p21 and p53 protein levels, and decreased beta-catenin, N-cadherin, vimentin, phospho-AKT, matrix metalloproteinase-2 and matrix metalloproteinase-9 protein levels. evodiamine 50-60 vimentin Homo sapiens 202-210 30126001-10 2018 Overexpression of miR-150-5p led to an obvious decrease in E-cadherin expression, but enhanced N-cadherin, Slug and Vimentin, ZEB1, and Snail expression. mir-150-5p 18-28 vimentin Homo sapiens 116-124 29978911-9 2018 Moreover, protopheophorbide A exhibited anti-migratory properties (IC50 = 2.2 muM) through impacting the expression levels of E-cadherin, vimentin, beta-catenin, FAK, Brk, Rac, and Src proteins. protopheophorbide a 10-29 vimentin Homo sapiens 139-147 29980789-5 2018 The in vitro and in vivo treatment of myxoid liposarcoma with trabectedin, a drug with a potent anti-tumor activity, revealed downregulation of HMGA1, E2F1, and its-downstream targets, vimentin and ZEB1, indicating a critical role of trabectedin in inhibiting the mesenchymal markers of these tumors through the HMGA1/E2F1 axis. Trabectedin 62-73 vimentin Homo sapiens 185-193 29991446-0 2018 Cell surface vimentin-targeted monoclonal antibody 86C increases sensitivity to temozolomide in glioma stem cells. Temozolomide 80-92 vimentin Homo sapiens 13-21 30015856-5 2018 It was also identified that blocking Notch signalling with the g-secretase inhibitor DAPT decreased the expression of the EMT markers Snail and vimentin and increased E-cadherin expression, accompanied by a significant inhibition of cell migration in the 2 OSCC cell lines. dapt 85-89 vimentin Homo sapiens 144-152 30066836-4 2018 Sequential treatment of GA cells with melatonin after IL-1beta challenge markedly reversed the IL-1beta-induced morphological changes, reduced cell invasion and migration, increased beta-catenin and E-cadherin expression, and downregulated fibronectin, vimentin, Snail, matrix metalloproteinase (MMP)2 and MMP9 expression. Melatonin 38-47 vimentin Homo sapiens 253-261 30033252-4 2018 The basic copolymer was prepared by radical copolymerization of N-isopropyl acryl amide (NIPAAm) and N-vinylimidazole (VIm). copolymer 10-19 vimentin Homo sapiens 119-122 30033252-4 2018 The basic copolymer was prepared by radical copolymerization of N-isopropyl acryl amide (NIPAAm) and N-vinylimidazole (VIm). N-vinylimidazole 101-117 vimentin Homo sapiens 119-122 29934325-5 2018 Following hypoxic growth conditions, HCC827 cells treated with gefitinib upregulated N-cadherin, fibronectin, and vimentin expression and downregulated E-cadherin, characteristic of an epithelial-mesenchymal transition (EMT), which prior studies have linked to EGFR TKI resistance. Gefitinib 63-72 vimentin Homo sapiens 114-122 28899457-7 2018 Swainsonine increased the expression of E-cadherin but decreased the expression of N-cadherin, vimentin, ZEB1, and snail in a dose-dependent manner, thereby inhibiting EMT. Swainsonine 0-11 vimentin Homo sapiens 95-103 29734086-2 2018 Styrene (ST) and N-vinylimidazole (VIM) were carbon and nitrogen sources, while the sulfonic acid functional groups introduced by the simple concentrated sulfuric acid sulfonation worked simultaneously as cross-linking agent and sulfur source during the following thermal treatments. Carbon 45-51 vimentin Homo sapiens 35-38 29734086-3 2018 It was found that the surface chemistries, textural structures, and CO2 adsorption performances of the NSCSs were significantly affected by the addition of VIM. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 68-71 vimentin Homo sapiens 156-159 29734086-4 2018 The NSCS-4-700 sample with a molar ratio of ST: VIM = 1: 0.75 showed the best CO2 uptake at different temperatures and pressures. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 78-81 vimentin Homo sapiens 48-51 30288061-9 2018 The results of Western blot demonstrated that the expression of TGF-beta1, ZEB1, Vimentin, and Snail in si AOC4P group were lower than that in si CT and CN group (P<0.05), and the expression of E-cadherin in si AOC4P group was higher than that in si CT and CN group (P<0.05). Silicon 56-58 vimentin Homo sapiens 81-89 30254570-4 2018 DA induced the reduction of the number of cellular processes, the increase of cell adhesion/spreading, and the increase of vimentin filaments in resting primary and BV2 microglia. Dopamine 0-2 vimentin Homo sapiens 123-131 30107167-8 2018 Pimozide dose-dependently inhibited cell proliferation and migration in both HCT116 and SW480 cells, increased expression of E-cadherin and decreased expression of N-cadherin, vimentin and Snail. Pimozide 0-8 vimentin Homo sapiens 176-184 30202514-6 2018 Furthermore, pantoprazole significantly downregulated mesenchymal markers (Snail1 and vimentin), upregulated epithelial marker (E-cadherin), and inhibited migration and invasion of AGS and MKN-28 cells. Pantoprazole 13-25 vimentin Homo sapiens 86-94 30017802-8 2018 The up-regulation of E-cadherin and the down-regulation of vimentin for both SW480 and HCT116 cells revealed the anti-EMT abilities of metformin. Metformin 135-144 vimentin Homo sapiens 59-67 29475041-6 2018 The results showed that AC-MFB was not only able to upregulate the expression of Ecadherin and attenuate the TGF-beta-induced overexpression of vimentin and N-cadherin, but it also reversed the TGF-beta-induced changes in cell morphology from polygonal to spindle-shaped and delayed the migration potential of BE3 cells. ac-mfb 24-30 vimentin Homo sapiens 144-152 29916527-6 2018 The results of immunofluorescence staining indicated that oligomycin A and antimycin A downregulated cortical E-cadherin expression and upregulated the expression of Vimentin. oligomycin A 58-70 vimentin Homo sapiens 166-174 29916527-6 2018 The results of immunofluorescence staining indicated that oligomycin A and antimycin A downregulated cortical E-cadherin expression and upregulated the expression of Vimentin. Antimycin A 75-86 vimentin Homo sapiens 166-174 29916527-9 2018 Conversely, treatment with the AKT inhibitor wortmannin and the AMPK inhibitor Compound C upregulated E-cadherin and downregulated Vimentin expression. Wortmannin 45-55 vimentin Homo sapiens 131-139 30128012-3 2018 Western blotting demonstrated that treatment with Mn12Ac was able to upregulate E-cadherin, and downregulate N-cadherin and vimentin. mn12ac 50-56 vimentin Homo sapiens 124-132 30181714-0 2018 MiR-876-5p modulates head and neck squamous cell carcinoma metastasis and invasion by targeting vimentin. mir-876-5p 0-10 vimentin Homo sapiens 96-104 30143678-4 2018 In addition, we showed that niclosamide inhibits the epithelial-to-mesenchymal transition (EMT), migration and colony formation of the OSCC cells, by dose-dependently upregulating E-cadherin and the tissue inhibitor of metalloproteinases 2 (TIMP2) mRNA levels, while reducing the expression levels of vimentin, snail, MMP2 and MMP9 mRNA. Niclosamide 28-39 vimentin Homo sapiens 301-309 30135525-11 2018 miR-509 exposure inhibited vimentin phosphorylation at Ser-56, vimentin network reorganization, focal adhesion formation, and cell migration. mir-509 0-7 vimentin Homo sapiens 27-35 30135525-11 2018 miR-509 exposure inhibited vimentin phosphorylation at Ser-56, vimentin network reorganization, focal adhesion formation, and cell migration. mir-509 0-7 vimentin Homo sapiens 63-71 30135525-11 2018 miR-509 exposure inhibited vimentin phosphorylation at Ser-56, vimentin network reorganization, focal adhesion formation, and cell migration. Serine 55-58 vimentin Homo sapiens 27-35 30135525-12 2018 The effects of miR-509 on ERK1/2 and vimentin were diminished in RNAi-resistant Plk1 expressing cells treated with miR-509. mir-509 15-22 vimentin Homo sapiens 37-45 30135525-12 2018 The effects of miR-509 on ERK1/2 and vimentin were diminished in RNAi-resistant Plk1 expressing cells treated with miR-509. mir-509 115-122 vimentin Homo sapiens 37-45 30135525-14 2018 miR-509 controls vimentin cytoskeleton reorganization, focal adhesion assembly, and cell migration through Plk1. mir-509 0-7 vimentin Homo sapiens 17-25 30120381-5 2018 Once translocated, UBXD1 recruits p97 to mitochondria via a bipartite binding motif consisting of its N-terminal VIM and PUB domains. bipartite 60-69 vimentin Homo sapiens 113-116 30103475-7 2018 We also showed that 4-AAQB-induced re-expression of hsa-miR-324-5p, akin to short-interfering RNA, reduced SOD2 expression, correlates with the concurrent down-regulation of SOD2, N-cadherin, vimentin, c-Myc, and BcL-xL2, with concomitant up-regulation of E-cadherin and BAX2 proteins. 4-acetylantroquinonol B 20-26 vimentin Homo sapiens 192-200 29999323-4 2018 The cooperative competition of the hydrophilic quaternary vinylimidazole moieties and hydrophobic long alkyl side chains determines the thermal sensitive behavior of the P(NIPAm/VIM nBr) microgels. quaternary vinylimidazole 47-72 vimentin Homo sapiens 178-181 29999323-4 2018 The cooperative competition of the hydrophilic quaternary vinylimidazole moieties and hydrophobic long alkyl side chains determines the thermal sensitive behavior of the P(NIPAm/VIM nBr) microgels. Phosphorus 170-171 vimentin Homo sapiens 178-181 29999323-4 2018 The cooperative competition of the hydrophilic quaternary vinylimidazole moieties and hydrophobic long alkyl side chains determines the thermal sensitive behavior of the P(NIPAm/VIM nBr) microgels. N-isopropylacrylamide 172-177 vimentin Homo sapiens 178-181 30211312-9 2018 For example, ALDH1A1, CAV1, and VIM were upregulated in DTC pools relative to CTCs. dtc 56-59 vimentin Homo sapiens 32-35 30186426-7 2018 Acetaldehyde presented a mesenchymal cell characteristic in hepatocytes, accompanied by an increased expression of mesenchymal markers, including vimentin and fibronectin, and decreased E-cadherin. Acetaldehyde 0-12 vimentin Homo sapiens 146-154 30186426-8 2018 Baicalin and puerarin abrogated the increased expression of vimentin and fibronectin, and rescued E-cadherin expression in acetaldehyde-treated hepatocytes. puerarin 13-21 vimentin Homo sapiens 60-68 30186426-13 2018 Puerarin regulated the mRNA level of TGF-betal, Smad3 and snail, suppresing the EMT process, which was accompanied by an increased mRNA level of E-cadherin and decreased levels of vimentin and fibronectin, along with increased levels of occludin, ZO-1 and claudin. puerarin 0-8 vimentin Homo sapiens 180-188 30317802-10 2018 Additionally, the level of the mesenchymal marker (a-SMA, vimentin) dramatically increased with PQ treatment in the same concentration-and time-dependent manner (P<0.05) . Primaquine 96-98 vimentin Homo sapiens 58-66 29767234-4 2018 Importantly, miR-125a-5p enhanced the cytotoxic effects of cisplatin on EC1 and TE1 cells, and co-treatment with miR-125a-5p and cisplatin significantly induced cell apoptosis and reduced the cell migratory and invasive abilities of EC1 and TE1 cells, coupled with an increase in the E-cadherin level and a decrease in the N-cadherin and Vimentin levels. Cisplatin 59-68 vimentin Homo sapiens 338-346 29767234-4 2018 Importantly, miR-125a-5p enhanced the cytotoxic effects of cisplatin on EC1 and TE1 cells, and co-treatment with miR-125a-5p and cisplatin significantly induced cell apoptosis and reduced the cell migratory and invasive abilities of EC1 and TE1 cells, coupled with an increase in the E-cadherin level and a decrease in the N-cadherin and Vimentin levels. mir-125a-5p 113-124 vimentin Homo sapiens 338-346 29767234-4 2018 Importantly, miR-125a-5p enhanced the cytotoxic effects of cisplatin on EC1 and TE1 cells, and co-treatment with miR-125a-5p and cisplatin significantly induced cell apoptosis and reduced the cell migratory and invasive abilities of EC1 and TE1 cells, coupled with an increase in the E-cadherin level and a decrease in the N-cadherin and Vimentin levels. Cisplatin 129-138 vimentin Homo sapiens 338-346 29989651-6 2018 At the protein level, osthole affected the expression of cervical cancer cell epithelial-mesenchymal transition markers, which showed that the expression of E-cadherin was increased, whereas that of vimentin was decreased. osthol 22-29 vimentin Homo sapiens 199-207 30008931-6 2018 The results demonstrated that oridonin effectively inhibited EMT as demonstrated by the significant increases in the expression levels of E-cadherin, and decreased expression of N-cadherin, Vimentin and Snail. oridonin 30-38 vimentin Homo sapiens 190-198 30013633-6 2018 In addition, DRAM1 knockdown increased the expression of E-Cadherin while decreased the expression of vimentin in HepG2 cells, which was also be reversed by rapamycin treatment. Sirolimus 157-166 vimentin Homo sapiens 102-110 30013652-6 2018 Results from western blot analysis demonstrated that juglone increases the expression of the epithelial marker E-cadherin while decreasing the expression of mesenchymal markers (N-cadherin and Vimentin) in a dose-dependent manner. juglone 53-60 vimentin Homo sapiens 193-201 29741670-9 2018 In the RNA-seq data, cadmium downregulated HIF-1alpha target genes including LOXL2, ZEB1, and VIM. Cadmium 21-28 vimentin Homo sapiens 94-97 29979638-8 2018 Carbapenem-resistant GNPs were characterized by multiplex polymerase chain reaction for IMP, VIM, SPM, OXA-48, NDM, KPC, BIC, AIM, GIM, SIM, and DIM. Carbapenems 0-10 vimentin Homo sapiens 93-96 30002278-7 2018 It is noteworthy that resveratrol strongly suppressed TNF-beta-induced activation of tumor-promoting factors (NF-kappaB, MMP-9, CXCR4) and epithelial-to-mesenchymal-transition-factors (increased vimentin and slug, decreased E-cadherin) in CRC cells. Resveratrol 22-33 vimentin Homo sapiens 195-203 29976237-12 2018 Quantification of the examined molecules revealed that the median intensity of TUB, GLU, and VIM was significantly increased in patients with metastatic BC compared with those with early disease (TUB, 62.27 vs 11.5, p = 0.0001; GLU, 6.99 vs 5.29, p = 0.029; and VIM, 8.24 vs 5.38, p = 0.0001, respectively). Glutamic Acid 228-231 vimentin Homo sapiens 93-96 29698684-6 2018 Furthermore, mechanical balance of cytoskeleton (actin, tubulin and vimentin) contributed to acidic pHe-triggered protrusion and morphology change. Phenylalanine 100-103 vimentin Homo sapiens 68-76 29790698-11 2018 Berberine remarkably down-regulated expression of E-cadherin and up-regulated expression of vimentin and alpha-SMA compared to the control (p < 0.01 or p < 0.001). Berberine 0-9 vimentin Homo sapiens 92-100 29715584-5 2018 First, we showed that 5-FU-resistant SNUC5 colon cancer cells (SNUC5/FUR cells) undergo EMT by analyzing the expression of EMT markers such as N-cadherin, vimentin and E-cadherin. Fluorouracil 22-26 vimentin Homo sapiens 155-163 29693702-5 2018 In addition, treatment with 50 micromol/l FxOH suppressed N-cadherin and vimentin expression and the activation of integrin signaling linked to EMT suppression by western blot analysis. fxoh 42-46 vimentin Homo sapiens 73-81 29767267-0 2018 HDAC inhibitors, trichostatin A and valproic acid, increase E-cadherin and vimentin expression but inhibit migration and invasion of cholangiocarcinoma cells. trichostatin A 17-31 vimentin Homo sapiens 75-83 29767267-0 2018 HDAC inhibitors, trichostatin A and valproic acid, increase E-cadherin and vimentin expression but inhibit migration and invasion of cholangiocarcinoma cells. Valproic Acid 36-49 vimentin Homo sapiens 75-83 29673704-4 2018 Only concurrent but not individual exposure to OTA and CIT at nanomolar concentrations led to (i) an increase of TNF protein and mRNA, (ii) a decrease of COX-2 protein and mRNA, (iii) a decrease of E-cadherin protein and (iv) an increase of vimentin and alpha-SMA protein. Citrinin 55-58 vimentin Homo sapiens 241-249 29880900-4 2018 We found that miR-16-5p was significantly downregulated in chordoma, and overexpression of miR-16-5p suppressed chordoma cell proliferation, invasion and migration in vitro and in vivo and correlated with the upregulated expression of E-cadherin and downregulated expression of N-cadherin and vimentin. mir-16-5p 14-23 vimentin Homo sapiens 293-301 29635803-9 2018 Metformin inhibited vimentin expression in both normal and tumor cells. Metformin 0-9 vimentin Homo sapiens 20-28 29896243-6 2018 The results demonstrated that high glucose (HG; 30 mmol/l) caused CRC cells to lose their epithelial morphology, with a decrease in E-cadherin and an increase in vimentin, suggesting epithelial-mesenchymal transition (EMT). Glucose 35-42 vimentin Homo sapiens 162-170 29665365-6 2018 Moreover, DHE treatment suppressed the epithelial-mesenchymal transition (EMT) process in NB cells by promoting the expression of E-cadherin (E-cad) and restraining the expressions of N-cadherin (N-cad) and vimentin. dehydroeffusol 10-13 vimentin Homo sapiens 207-215 29804448-6 2018 Among the NCG-associated amino acids, arginine and glutamine, markedly increased PGRMC1 and eNOS expression in porcine trophectoderm cells ( P < 0.05), whereas glutamate could stimulate the expression of vimentin and lamin A/C in porcine trophectoderm (pTr) cells ( P < 0.05) and proline stimulated lamin A/C expression ( P < 0.05). Arginine 38-46 vimentin Homo sapiens 207-215 29804448-6 2018 Among the NCG-associated amino acids, arginine and glutamine, markedly increased PGRMC1 and eNOS expression in porcine trophectoderm cells ( P < 0.05), whereas glutamate could stimulate the expression of vimentin and lamin A/C in porcine trophectoderm (pTr) cells ( P < 0.05) and proline stimulated lamin A/C expression ( P < 0.05). Glutamine 51-60 vimentin Homo sapiens 207-215 29804448-6 2018 Among the NCG-associated amino acids, arginine and glutamine, markedly increased PGRMC1 and eNOS expression in porcine trophectoderm cells ( P < 0.05), whereas glutamate could stimulate the expression of vimentin and lamin A/C in porcine trophectoderm (pTr) cells ( P < 0.05) and proline stimulated lamin A/C expression ( P < 0.05). Glutamic Acid 163-172 vimentin Homo sapiens 207-215 29880900-4 2018 We found that miR-16-5p was significantly downregulated in chordoma, and overexpression of miR-16-5p suppressed chordoma cell proliferation, invasion and migration in vitro and in vivo and correlated with the upregulated expression of E-cadherin and downregulated expression of N-cadherin and vimentin. mir-16-5p 91-100 vimentin Homo sapiens 293-301 29928330-6 2018 Furthermore, LSD1 knockdown plus cisplatin synergistically impaired cell migration via the induction of the epithelial marker E-cadherin and inhibition of the mesenchymal markers, snail family transcriptional repressor 1 and Vimentin. Cisplatin 33-42 vimentin Homo sapiens 225-233 29528563-10 2018 Higher vimentin expressions were detected in cells cultured with cDMEM and Ectoine+cDMEM media, respectively. cdmem 65-70 vimentin Homo sapiens 7-15 29528563-10 2018 Higher vimentin expressions were detected in cells cultured with cDMEM and Ectoine+cDMEM media, respectively. ectoine 75-82 vimentin Homo sapiens 7-15 29528563-10 2018 Higher vimentin expressions were detected in cells cultured with cDMEM and Ectoine+cDMEM media, respectively. cdmem 83-88 vimentin Homo sapiens 7-15 29345333-10 2018 Moreover, puerarin suppressed cell migration, invasion and up-regulated E-Cadherin expression as well as down-regulated Vimentin and alpha-SMA expression. puerarin 10-18 vimentin Homo sapiens 120-128 29548818-7 2018 The expression of Vimentin, N-cadherin, MMP-7, snail and slug was significantly inhibited by MK-2206, while the expression of E-cadherin was upregulated. MK 2206 93-100 vimentin Homo sapiens 18-26 29801408-8 2018 Theresults showed that administration of curcumin in all the dose administered were incapable improving the expressionsof vimentin, TGF-beta1 and E-cadherin. Curcumin 41-49 vimentin Homo sapiens 122-130 29805610-7 2018 Expression of CD133 and vimentin was upregulated by treatment with the TGF-beta receptor antagonist SB431542, but not with TGF-beta. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 100-108 vimentin Homo sapiens 24-32 29754471-10 2018 Finally, addition of LiCl (Wnt/beta-catenin pathway activator) or XAV93920 (Wnt/beta-catenin pathway inhibitor) would cause remarkably altered E-cadherin, c-Myc, vimentin and snail expressions, as well as significantly changed transcriptional activity of beta-catenin/Tcf reporter plasmid (P < 0.05). Lithium Chloride 21-25 vimentin Homo sapiens 162-170 29635011-10 2018 Interestingly, short-spacer bifunctional cysteine crosslinking produces GFAP-vimentin heterodimers, suggesting that a certain proportion of cysteine residues from both proteins are spatially close. Cysteine 41-49 vimentin Homo sapiens 77-85 29635011-10 2018 Interestingly, short-spacer bifunctional cysteine crosslinking produces GFAP-vimentin heterodimers, suggesting that a certain proportion of cysteine residues from both proteins are spatially close. Cysteine 140-148 vimentin Homo sapiens 77-85 29724197-15 2018 An excess amount of Nup88 in cell lysates inhibited the dephosphorylation of a serine residue (Ser83) within the vimentin N-terminal region even in the absence and presence of an exogenous phosphatase. Serine 79-85 vimentin Homo sapiens 113-121 29401610-0 2018 An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells. Simvastatin 99-110 vimentin Homo sapiens 48-56 27556820-8 2018 Furthermore, in vitro experiments showed that withaferin-A, a chemical inhibitor of vimentin, could inhibit GBM cell migration and invasion activity when its concentrations were <0.5 muM, and higher concentrations of withaferin-A could decrease the viability of U251and U87 cells significantly. withaferin A 46-58 vimentin Homo sapiens 84-92 27556820-8 2018 Furthermore, in vitro experiments showed that withaferin-A, a chemical inhibitor of vimentin, could inhibit GBM cell migration and invasion activity when its concentrations were <0.5 muM, and higher concentrations of withaferin-A could decrease the viability of U251and U87 cells significantly. withaferin A 220-232 vimentin Homo sapiens 84-92 29575318-7 2018 An EMT biomarker, vimentin, was highly expressed in 2 TNBC cell lines when they were compared with SK-BR-3 and T-47D cells. sk-br-3 99-106 vimentin Homo sapiens 18-26 29951338-8 2018 EL downregulates the mesenchymal markers N-cadherin and vimentin, and upregulates the epithelial markers E-cadherin and occludin. 2,3-bis(3'-hydroxybenzyl)butyrolactone 0-2 vimentin Homo sapiens 56-64 29401610-11 2018 In conclusion, this study identified vimentin as a direct molecular target that mediates simvastatin-induced cell death in 2 different cancer cell lines.-Trogden, K. P., Battaglia, R. A., Kabiraj, P., Madden, V. J., Herrmann, H., Snider, N. T. An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells. Simvastatin 89-100 vimentin Homo sapiens 37-45 29401610-11 2018 In conclusion, this study identified vimentin as a direct molecular target that mediates simvastatin-induced cell death in 2 different cancer cell lines.-Trogden, K. P., Battaglia, R. A., Kabiraj, P., Madden, V. J., Herrmann, H., Snider, N. T. An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells. Simvastatin 89-100 vimentin Homo sapiens 292-300 29401610-11 2018 In conclusion, this study identified vimentin as a direct molecular target that mediates simvastatin-induced cell death in 2 different cancer cell lines.-Trogden, K. P., Battaglia, R. A., Kabiraj, P., Madden, V. J., Herrmann, H., Snider, N. T. An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells. Simvastatin 343-354 vimentin Homo sapiens 37-45 29989579-5 2018 After TSA treatment, the invasion and migration properties MDA-MB-231 cells significantly decreased, gene expression of E-cadherin was significantly up-regulated, while the levels of Slug and Vimentin encoding mRNAs were suppressed. trichostatin A 6-9 vimentin Homo sapiens 192-200 29161937-4 2018 We investigated that the ability of silica-induced EMT in A549 cells, and this process was significantly inhibited by SB431542 through up-regulation of Vimentin, alpha-SMA and collagen type I expression and down-regulation of E-cadherin expression. Silicon Dioxide 36-42 vimentin Homo sapiens 152-160 29161937-4 2018 We investigated that the ability of silica-induced EMT in A549 cells, and this process was significantly inhibited by SB431542 through up-regulation of Vimentin, alpha-SMA and collagen type I expression and down-regulation of E-cadherin expression. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 118-126 vimentin Homo sapiens 152-160 29401610-5 2018 Simvastatin induced vimentin reorganization within 15-30 min and significant perinuclear bundling within 60 min (IC50 = 6.7 nM). Simvastatin 0-11 vimentin Homo sapiens 20-28 29401610-9 2018 In SW13-vim+ cells, simvastatin, but not pravastatin, reduced total cell numbers (IC50 = 48.1 nM) and promoted apoptosis after 24 h. In contrast, SW13-vim- cell viability was unaffected by simvastatin, unless vimentin was ectopically expressed. Simvastatin 20-31 vimentin Homo sapiens 209-217 29401610-10 2018 Simvastatin similarly targeted vimentin filaments and induced cell death in MDA-MB-231 (vim+), but lacked effect in MCF7 (vim-) breast cancer cells. Simvastatin 0-11 vimentin Homo sapiens 31-39 29505894-9 2018 When MSC-derived cells were encapsulated in PEGDA hydrogels that mimic the leaflet modulus, a decrease in alphaSMA expression and increase in vimentin was observed. poly(ethylene glycol)diacrylate 44-49 vimentin Homo sapiens 142-150 29420338-9 2018 After curcumin treatment, drug-resistant cell proliferation was significantly inhibited; in the curcumin+irinotecan treatment group, E-cadherin expression was upregulated, whereas vimentin and N-cadherin expressions were downregulated. Curcumin 6-14 vimentin Homo sapiens 180-188 29266801-8 2018 The most citrulline-specific antibodies in the sputum of at-risk subjects were those to fibrinogen, vimentin, and peptides of fibrinogen A and apolipoprotein A1. Citrulline 9-19 vimentin Homo sapiens 100-108 29581735-6 2018 It was observed that doxorubicin resistance in colon cancer also induced epithelial to mesenchymal transition, a decrease in expression of epithelial marker E-cadherin and an increase in the expression of mesenchymal markers, including N-cadherin and vimentin. Doxorubicin 21-32 vimentin Homo sapiens 251-259 29393450-10 2018 Inhibiting ERK through treatment with U0126 significantly abrogated CUL7-induced alterations in Vimentin, SNAI2 and E-cadherin expression levels. U 0126 38-43 vimentin Homo sapiens 96-104 29552216-12 2018 Additionally, U0126 upregulated the expression of E-cadherin and downregulated the expression of vimentin. U 0126 14-19 vimentin Homo sapiens 97-105 29408667-0 2018 ZnSO4 rescued vimentin from collapse in DBP-exposed Sertoli cells by attenuating ER stress and apoptosis. Zinc Sulfate 0-5 vimentin Homo sapiens 14-22 29408667-6 2018 Treatment with BAPTA-AM, an antagonist of Ca2+, significantly decreased the level of phosphorylated vimentin, while LY294002, an inhibitor of Akt1, did not. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 15-23 vimentin Homo sapiens 100-108 29408667-10 2018 These results indicated that ZnSO4 could alleviate the collapse of vimentin by attenuating ER stress and apoptosis. Zinc Sulfate 29-34 vimentin Homo sapiens 67-75 29643037-7 2018 The cells exposed to high glucose and calycosin treatment showed significantly decreased mRNA levels of alpha-SMA and vimentin (P<0.05) and inhibited phosphorylation of SMAD2/3. Glucose 26-33 vimentin Homo sapiens 118-126 29725496-4 2018 Melatonin inhibited the migration and invasion of oral cancer cells by repressing ROS-activated Akt signaling, implicating with the reduction of Snail and Vimentin and the enhancement of E-cadherin. Melatonin 0-9 vimentin Homo sapiens 155-163 29725496-4 2018 Melatonin inhibited the migration and invasion of oral cancer cells by repressing ROS-activated Akt signaling, implicating with the reduction of Snail and Vimentin and the enhancement of E-cadherin. Reactive Oxygen Species 82-85 vimentin Homo sapiens 155-163 29643037-7 2018 The cells exposed to high glucose and calycosin treatment showed significantly decreased mRNA levels of alpha-SMA and vimentin (P<0.05) and inhibited phosphorylation of SMAD2/3. 7,3'-dihydroxy-4'-methoxyisoflavone 38-47 vimentin Homo sapiens 118-126 29643037-9 2018 CONCLUSION: In endothelial cells with high glucose-induced injury, calycosin can inhibit the up-regulation of alpha-SMA and vimentin and inhibit phosphorylation of SMAD2/3 to regulate endothelial-mesenchymal transition and improve diabetic nephropathy. 7,3'-dihydroxy-4'-methoxyisoflavone 67-76 vimentin Homo sapiens 124-132 29513221-4 2018 Here, we show that site-specific modification of the prototypical IF protein vimentin with O-linked beta-N-acetylglucosamine (O-GlcNAc) mediates its homotypic protein-protein interactions and is required in human cells for IF morphology and cell migration. o-linked beta-n-acetylglucosamine 91-124 vimentin Homo sapiens 77-85 29547514-4 2018 Moreover, beta-asarone suppressed EMT with the up-regulation of E-cadherin and the down-regulation of vimentin. asarone 10-22 vimentin Homo sapiens 102-110 29538296-10 2018 Moreover, knockdown of CHOP or ATG5 and treatment with 4-PBA or 3-MA abolished the SH-mediated inhibition of mesenchymal markers (vimentin, Snail and Slug) expression and cell invasion, respectively. 4-phenylbutyric acid 55-60 vimentin Homo sapiens 130-138 29538296-10 2018 Moreover, knockdown of CHOP or ATG5 and treatment with 4-PBA or 3-MA abolished the SH-mediated inhibition of mesenchymal markers (vimentin, Snail and Slug) expression and cell invasion, respectively. 3-methyladenine 64-68 vimentin Homo sapiens 130-138 29513221-4 2018 Here, we show that site-specific modification of the prototypical IF protein vimentin with O-linked beta-N-acetylglucosamine (O-GlcNAc) mediates its homotypic protein-protein interactions and is required in human cells for IF morphology and cell migration. o-glcnac 126-134 vimentin Homo sapiens 77-85 28771721-6 2018 Treatment with the proteasomal inhibitor MG-132 revealed that vimentin is actively degraded by the proteasome in Moody cells and stabilized in the SKOV-3 cell line. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 41-47 vimentin Homo sapiens 62-70 29139094-13 2018 CONCLUSION: Curcumin might have therapeutic potential in breast cancer through regulating breast cancer-related genes, including SERPINE1, PGAP3, MAP3K1, MAPK1, GSTO2, VIM, SPARC, and FGF2. Curcumin 12-20 vimentin Homo sapiens 168-171 28771721-7 2018 Mass spectrometric analysis of vimentin immunoprecipitate of MG-132 treated Moody cells revealed candidate ubiquitin ligases associated with vimentin. Magnesium 61-63 vimentin Homo sapiens 31-39 28771721-7 2018 Mass spectrometric analysis of vimentin immunoprecipitate of MG-132 treated Moody cells revealed candidate ubiquitin ligases associated with vimentin. Magnesium 61-63 vimentin Homo sapiens 141-149 29344654-4 2018 Western blotting, immunohistochemistry, apoptotic assays and immunofluorescence were used to analyze the therapeutic effects of tunicamycin on apoptosis, growth, aggressiveness and cell cycle of colon tumor cells, by downregulation of fibronectin, vimentin and E-cadherin expression levels. Tunicamycin 128-139 vimentin Homo sapiens 248-256 29519321-0 2018 Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factor alpha - 1 expression. parthenolide 0-12 vimentin Homo sapiens 49-57 29519321-4 2018 PURPOSE: We examined the expression of vimentin and Elongation factor alpha - 1 as breast cancer biomarkers in MCF7 cells exposure to Parthenolide. parthenolide 134-146 vimentin Homo sapiens 39-47 29519321-6 2018 RESULT: Comparative proteome analyses are shown Elongation factor1-alpha and vimentin was suppressed in response to Parthenolide treatment. parthenolide 116-128 vimentin Homo sapiens 77-85 29316252-5 2018 Western blotting assay further showed that Mn12Ac significantly upregulated E-cadherin, and downregulated N-cadherin and vimentin. mn12ac 43-49 vimentin Homo sapiens 121-129 29495431-7 2018 The combination of FIS and PTX significantly reduced cancer cell migration and invasion, at least partially, through a marked rearrangement of actin and vimentin cytoskeleton and the modulation of metastasis-related genes. Paclitaxel 27-30 vimentin Homo sapiens 153-161 31938221-9 2018 Meanwhile, 125I could inhibit invasion of NSCLC cells by altering the expression level of vimentin, N-cadherin and MMP-9. 2-iodotyrosine 11-15 vimentin Homo sapiens 90-98 29374144-4 2018 Data revealed that PTX-resistant GC cells were characterized by microtubular disorders, an EMT phenotype, reduced responses to antimitotic drugs, and resistance to apoptosis (marked by upregulated beta-tubulin III, vimentin, attenuated changes in G2/M molecules or pro-apoptotic factors in response to antimitotic drugs or apoptotic inducers, respectively). Paclitaxel 19-22 vimentin Homo sapiens 215-223 29374219-4 2018 TSA or SAHA inhibited vimentin, HDACs 1, 7 and 8, upregulated E-cadherin mRNA and protein levels in the PDAC cells, and time-dependently downregulated Oct-4, Sox-2, and Nanog, as well as inhibited PDAC tumorsphere formation. trichostatin A 0-3 vimentin Homo sapiens 22-30 29374219-4 2018 TSA or SAHA inhibited vimentin, HDACs 1, 7 and 8, upregulated E-cadherin mRNA and protein levels in the PDAC cells, and time-dependently downregulated Oct-4, Sox-2, and Nanog, as well as inhibited PDAC tumorsphere formation. Vorinostat 7-11 vimentin Homo sapiens 22-30 30146805-8 2018 The mRNA expression of E-cadherin and vimentin, and the activated ERK1/2 were significantly increased after 1.0 nmol/L FK866 treatment for 72 h. The pretreatment with nicotinamide adenine dinucleotide (NAD) precursor nicotinamide mononucleotide(1.0 mmol/L) or ERK1/2 inhibitor U0126 (10.0 mumol/L) reversed the up-regulation of E-cadherin and vimentin expression induced by FK866. N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 119-124 vimentin Homo sapiens 38-46 30146805-8 2018 The mRNA expression of E-cadherin and vimentin, and the activated ERK1/2 were significantly increased after 1.0 nmol/L FK866 treatment for 72 h. The pretreatment with nicotinamide adenine dinucleotide (NAD) precursor nicotinamide mononucleotide(1.0 mmol/L) or ERK1/2 inhibitor U0126 (10.0 mumol/L) reversed the up-regulation of E-cadherin and vimentin expression induced by FK866. N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 119-124 vimentin Homo sapiens 343-351 30146805-8 2018 The mRNA expression of E-cadherin and vimentin, and the activated ERK1/2 were significantly increased after 1.0 nmol/L FK866 treatment for 72 h. The pretreatment with nicotinamide adenine dinucleotide (NAD) precursor nicotinamide mononucleotide(1.0 mmol/L) or ERK1/2 inhibitor U0126 (10.0 mumol/L) reversed the up-regulation of E-cadherin and vimentin expression induced by FK866. NAD 167-200 vimentin Homo sapiens 38-46 30146805-8 2018 The mRNA expression of E-cadherin and vimentin, and the activated ERK1/2 were significantly increased after 1.0 nmol/L FK866 treatment for 72 h. The pretreatment with nicotinamide adenine dinucleotide (NAD) precursor nicotinamide mononucleotide(1.0 mmol/L) or ERK1/2 inhibitor U0126 (10.0 mumol/L) reversed the up-regulation of E-cadherin and vimentin expression induced by FK866. NAD 167-200 vimentin Homo sapiens 343-351 29623041-2 2018 Inadequate therapy motivated us to explore the effect of vimentin inhibitor Withaferin A, as an anti-fibrotic agent against TGF-beta1-induced in vitro fibrotic events and Bleomycin induced in vivo fibrosis with an emphasis on epithelial to mesenchymal transition (EMT), extracellular matrix deposition (ECM), inflammation, and angiogenesis. withaferin A 76-88 vimentin Homo sapiens 57-65 29623041-2 2018 Inadequate therapy motivated us to explore the effect of vimentin inhibitor Withaferin A, as an anti-fibrotic agent against TGF-beta1-induced in vitro fibrotic events and Bleomycin induced in vivo fibrosis with an emphasis on epithelial to mesenchymal transition (EMT), extracellular matrix deposition (ECM), inflammation, and angiogenesis. Bleomycin 171-180 vimentin Homo sapiens 57-65 29681982-9 2018 Interestingly, EGF-induced expressions of vimentin, snail, and slug were suppressed through the inhibition of PI3K/Akt and ERK signaling pathway in propolin C-treated cells. propolin C 148-158 vimentin Homo sapiens 42-50 28994107-6 2018 Analysis of cells (U87MG/A172) exposed to severe hypoxia (0.2%O2 ) revealed elevated mRNA expression of FAT1, EMT (Snail/LOX/Vimentin/N-cad), stemness (SOX2/OCT4/Nestin/REST) and hypoxia markers (HIF-1alpha/PGK1/VEGF/CA9) as compared to their normoxic (20%O2 ) counterparts. Oxygen 62-64 vimentin Homo sapiens 125-133 29396560-4 2018 One pazopanib cycle significantly decreased the number of CTCs as detected by CellSearch (p = 0.043) as well as the number of CK+/Ki67+ (p < 0.001), CK+/M30+ (p = 0.015) and CK+/Vim+ (p < 0.001) cells. pazopanib 4-13 vimentin Homo sapiens 181-184 28816009-4 2018 After atazanavir sulphate treatment, in A549 cells and HPMECs, the expression of vimentin, HMGB1, Toll-like receptor 4 (TLR-4) and p-NF-kappaB decreased, while the expression of E-cadherin and VE-cadherin increased. Atazanavir Sulfate 6-25 vimentin Homo sapiens 81-89 28471474-8 2018 Expression of lypolysaccharide (LPS)-induced activation markers (vimentin, alphaSMA) was evaluated by qPCR and immunoblotting. lypolysaccharide 14-30 vimentin Homo sapiens 65-73 29793319-7 2018 In addition, the migration of glioma cells was dramatically inhibited by oroxyloside in a dose-dependent manner, which was related to its modulation on extracellular matrix (ECM), as evidenced by up-regulated E-cadherin, and metastasis-associated protein 3 (MTA3), whereas down-regulated N-cadherin, Vimentin, Twist, alpha-smooth muscle actin (alpha-SMA) and Syndecan-2. oroxylin A-7-O-glucuronide 73-84 vimentin Homo sapiens 300-308 29553100-8 2018 FL118 significantly suppressed the expression of vimentin while enhancing the expression of E-cadherin. 7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione 0-5 vimentin Homo sapiens 49-57 28159699-5 2018 Clomipramine decreased protein levels of GFAP, as well as vimentin and nestin, and did not affect astrocyte resilience to oxidative stress. Clomipramine 0-12 vimentin Homo sapiens 58-66 29614624-9 2018 Furthermore, we found that Baicalein significantly inhibited cell invasion and Epithelial-Mesenchymal Transition (EMT) by up-regulating the mRNA and protein expression of E-cadherin and down-regulated the Twist1 and Vimentin expression, Moreover, Treatment of Baicalein down-regulated Notch1 and hes-1 expression in A549 and H1299 cells, which indicated that Baicalein could suppress the Notch signaling pathway. baicalein 27-36 vimentin Homo sapiens 216-224 30165352-9 2018 In addition, increased p-vimentin expression induced by oxLDL was significantly inhibited by ROCK2 deletion or Y27632 treatment. Y 27632 111-117 vimentin Homo sapiens 25-33 30165352-13 2018 Furthermore, ROCK2 deficiency or Y27632 treatment inhibited the redistribution of adhesion molecules and their co-localization with vimentin caused by oxLDL. Y 27632 33-39 vimentin Homo sapiens 132-140 30355923-13 2018 In addition, Erinacine was found to decrease the mitochondrial membrane potential, expression of PI3K, Akt, GSK-3beta, CyclinD1, Vimentin, beta-catenin, and Bcl-2, cell proliferation, colony formation ability, migration, invasion, and xenograft tumor size, while E-cadherin, Bax, and caspase-9 expression, and cell apoptosis were elevated in a dose-dependent manner. erinacine S 13-22 vimentin Homo sapiens 129-137 30097951-1 2018 We report here a one-step method using the household detergent Vim Ultra to destain sodium dodecyl sulfate-polyacrylamide protein gels stained with Coomassie Brilliant Blue. Sodium Dodecyl Sulfate 84-106 vimentin Homo sapiens 63-66 29115520-12 2018 Furthermore, pretreatment with cyclopamine or predepletion of Gli-1 by siRNA also eliminated the changes of Snail, vimentin and E-cadherin, and HCC invasion and EMT caused by CCL2. cyclopamine 31-42 vimentin Homo sapiens 115-123 29213108-7 2017 Melatonin also decreased Epithelial mesenchymal transition (EMT) related gene expressions including ZEB1, ZEB2, snail and vimentin with increase in E-cadherin as a negative EMT regulator. Melatonin 0-9 vimentin Homo sapiens 122-130 29069458-8 2017 The results were consistent when modelling variability of TC using SD and VIM, and in various sensitivity analyses. Technetium 58-60 vimentin Homo sapiens 74-77 29312505-4 2017 Our results showed that curcumin attenuated the high expression levels of fibroblast proteins (alpha-SMA & Vimentin) in GC-MSCs. Curcumin 24-32 vimentin Homo sapiens 111-119 29340100-6 2017 Treatment of Cd recovered E-cadherin levels and inhibited vimentin levels while TGF-beta treatment significantly increased the expression of vimentin and PGC-1alpha, and decreased E-cadherin levels in SKOV-3 cells, indicating that the action of Cd on cancer stemness may contribute to the regulation of epithelial-mesenchymal transition (EMT). cordycepin 13-15 vimentin Homo sapiens 58-66 28975405-11 2017 Carboplatin treatment could significantly increase the expression of SERPINE1 and induce the EMT process, with decreased expression of E-cadherin and increased expression of Vimentin, Snail and Twist. Carboplatin 0-11 vimentin Homo sapiens 174-182 28982949-6 2017 The propidium iodide-positive cells stained positive for annexin V, negative for vimentin and pale for toluidine blue. Propidium 4-20 vimentin Homo sapiens 81-89 28098359-7 2017 M2-medium also induced changes in the epithelial-mesenchymal transition (EMT) markers E-cadherin, beta-catenin, vimentin, and snail in SW480 cells. m2-medium 0-9 vimentin Homo sapiens 112-120 29039572-4 2017 Additionally, thymoquinone reversed EMT by increasing E-cadherin expression and decreasing vimentin and Slug expression in a concentration-dependent manner. thymoquinone 14-26 vimentin Homo sapiens 91-99 28911876-9 2017 RESULTS: In this retrospective analysis of 24 KTxRs with TG, 16/24 (67%) patients with biopsy-proven TG developed Abs to vimentin (645+-427ng/ml). Thioguanine 57-59 vimentin Homo sapiens 121-129 28911876-9 2017 RESULTS: In this retrospective analysis of 24 KTxRs with TG, 16/24 (67%) patients with biopsy-proven TG developed Abs to vimentin (645+-427ng/ml). Thioguanine 101-103 vimentin Homo sapiens 121-129 28911876-11 2017 Of the patients with TG, 15/24 (63%) developed Abs to vimentin of IgG isotype (572+-276ng/ml), whereas only 6/24 (25%) stable KTxRs (310+-288ng/ml) had anti-vimentin of IgG isotype (p=0.002). Thioguanine 21-23 vimentin Homo sapiens 54-62 29416638-8 2018 Moreover, nicotine promotes migration, stemness and epithelial-mesenchymal transition (EMT) of hUC-MSCs by inhibiting E-cadherin expression and upregulating mesenchymal markers such as N-cadherin and Vimentin, leading to the induction of stem cell markers Sox2, Nanog, Sall4, Oct4 and CD44. Nicotine 10-18 vimentin Homo sapiens 200-208 29201006-6 2017 Protein and mRNA expression of vimentin, collagen I and fibronectin in eosinophil-induced epithelial cells were also significantly suppressed by tHGA treatment. 2,4,6-trihydroxy-3-geranylacetophenone 145-149 vimentin Homo sapiens 31-39 28970011-11 2017 Crocetin inhibited TGF-beta2-induced EMT in ARPE-19 cells by maintaining the expression of E-cadherin and ZO-1 and by reducing the expression of vimentin and alpha-SMA through the suppression of phosphorylation of p38. crocetin 0-8 vimentin Homo sapiens 145-153 29116196-7 2017 THL inhibited the TGF-beta1 induction of alpha-SMA, vimentin, MMP-2/-9 and collagen type IV expression and restored the morphological changes in primary alveolar epithelial cells caused by TGF-beta1. Thalidomide 0-3 vimentin Homo sapiens 52-60 28886987-7 2017 We determined that derivatives of retinoic acid led to significantly reduced level of proteins belonging to metabolic pathway (e.g. glyceraldehyde-3-phosphate dehydrogenase or pyruvate kinase 2) or to other cellular processes as apoptosis, regulation of transcription process or epithelial-mesenchymal transition (e.g. annexins, nucleoside diphosphate kinase B, vimentin). Tretinoin 34-47 vimentin Homo sapiens 362-370 28492136-5 2017 Afterward, treatment with the MEK1/2 inhibitor U0126 reduced the TGF-beta1-induced invasion and vimentin and MMP9 secretion in HepG2 cells, without affecting the inhibitory effects of TGF-beta1 on HepG2 cell proliferation. U 0126 47-52 vimentin Homo sapiens 96-104 29201239-10 2017 The expression of E-cadherin was significantly increased, while the expression of vimentin and N-cadherin was significantly decreased in ANXA1-overexpressing Tca-8113 and SCC-9 cells. Trichloroacetic Acid 158-161 vimentin Homo sapiens 82-90 29048609-9 2017 Immunoprecipitation data suggested an association between PKC-iota and vimentin and PKC-iota siRNA treatments confirmed that PKC-iota activates vimentin by phosphorylation. iota 62-66 vimentin Homo sapiens 71-79 29048609-9 2017 Immunoprecipitation data suggested an association between PKC-iota and vimentin and PKC-iota siRNA treatments confirmed that PKC-iota activates vimentin by phosphorylation. iota 62-66 vimentin Homo sapiens 144-152 28888487-3 2017 Further, in arsenite-transformed L-02 cells, the levels of E-cadherin were attenuated, but the levels of vimentin, which is expressed in mesenchymal cells, and Snail, a transcription regulator of the EMT, were up-regulated. arsenite 12-20 vimentin Homo sapiens 105-113 29027548-2 2017 The N-rich polymer dots are prepared from N-vinyl imidazole (VIm) by a one-pot hydrothermal synthesis at 220 C (24 h) and used later on to fabricate a Cu2+-PVIm dot complex via efficient incorporation of Cu2+ into aqueous medium. Polymers 11-18 vimentin Homo sapiens 61-64 29027548-2 2017 The N-rich polymer dots are prepared from N-vinyl imidazole (VIm) by a one-pot hydrothermal synthesis at 220 C (24 h) and used later on to fabricate a Cu2+-PVIm dot complex via efficient incorporation of Cu2+ into aqueous medium. N-vinylimidazole 42-59 vimentin Homo sapiens 61-64 29027548-2 2017 The N-rich polymer dots are prepared from N-vinyl imidazole (VIm) by a one-pot hydrothermal synthesis at 220 C (24 h) and used later on to fabricate a Cu2+-PVIm dot complex via efficient incorporation of Cu2+ into aqueous medium. cupric ion 152-156 vimentin Homo sapiens 61-64 29027548-2 2017 The N-rich polymer dots are prepared from N-vinyl imidazole (VIm) by a one-pot hydrothermal synthesis at 220 C (24 h) and used later on to fabricate a Cu2+-PVIm dot complex via efficient incorporation of Cu2+ into aqueous medium. pvim dot 157-165 vimentin Homo sapiens 61-64 29027548-2 2017 The N-rich polymer dots are prepared from N-vinyl imidazole (VIm) by a one-pot hydrothermal synthesis at 220 C (24 h) and used later on to fabricate a Cu2+-PVIm dot complex via efficient incorporation of Cu2+ into aqueous medium. cupric ion 205-209 vimentin Homo sapiens 61-64 29027548-3 2017 The obtained Cu2+-PVIm dot complexes display relaxivity (r1 = 1.05 mM-1 s-1) two times higher than Cu2+ in aqueous solution (r1 = 0.43 mM-1 s-1) and three times higher than Cu2+ in aqueous solution coordinated with VIm monomers (r1 = 0.32 mM-1 s-1), which show a remarkable contrast enhancement for T1-weighted MRI while efficiently labeling MCF-7 cells and other biomedical applications. cupric ion 13-17 vimentin Homo sapiens 19-22 29027548-3 2017 The obtained Cu2+-PVIm dot complexes display relaxivity (r1 = 1.05 mM-1 s-1) two times higher than Cu2+ in aqueous solution (r1 = 0.43 mM-1 s-1) and three times higher than Cu2+ in aqueous solution coordinated with VIm monomers (r1 = 0.32 mM-1 s-1), which show a remarkable contrast enhancement for T1-weighted MRI while efficiently labeling MCF-7 cells and other biomedical applications. cupric ion 99-103 vimentin Homo sapiens 19-22 29027548-3 2017 The obtained Cu2+-PVIm dot complexes display relaxivity (r1 = 1.05 mM-1 s-1) two times higher than Cu2+ in aqueous solution (r1 = 0.43 mM-1 s-1) and three times higher than Cu2+ in aqueous solution coordinated with VIm monomers (r1 = 0.32 mM-1 s-1), which show a remarkable contrast enhancement for T1-weighted MRI while efficiently labeling MCF-7 cells and other biomedical applications. cupric ion 99-103 vimentin Homo sapiens 19-22 28803991-7 2017 We found that DHEA increased expression of E-cadherin and decreased N-cadherin, vimentin and Snail expression both in MD-MB-231 cells and in the formed tumors, possibly by DHEA-induced reversion of mesenchymal phenotype. Dehydroepiandrosterone 14-18 vimentin Homo sapiens 80-88 28803991-7 2017 We found that DHEA increased expression of E-cadherin and decreased N-cadherin, vimentin and Snail expression both in MD-MB-231 cells and in the formed tumors, possibly by DHEA-induced reversion of mesenchymal phenotype. Dehydroepiandrosterone 172-176 vimentin Homo sapiens 80-88 28978905-5 2017 Physiologically, the process of LDL-derived cholesterol transport from lysosomes to the sites of its esterification is dependent on vimentin, which is a molecule comprising the cytoskeleton in mesenchymal cells. Cholesterol 44-55 vimentin Homo sapiens 132-140 30097951-1 2018 We report here a one-step method using the household detergent Vim Ultra to destain sodium dodecyl sulfate-polyacrylamide protein gels stained with Coomassie Brilliant Blue. polyacrylamide 107-121 vimentin Homo sapiens 63-66 30097951-1 2018 We report here a one-step method using the household detergent Vim Ultra to destain sodium dodecyl sulfate-polyacrylamide protein gels stained with Coomassie Brilliant Blue. coomassie Brilliant Blue 148-172 vimentin Homo sapiens 63-66 29328038-0 2017 QUANTITATIVE ASSESSMENT OF THE RESULTS OF VIMENTIN IMMUNOHISTOCHEMICAL EXAMINATION IN FIBROBLASTS AND ENDOTHELIOCYTES OF THE PLACENTAL VILLI IN THE ASPECT OF PRETERM MATURATION OF THE CHORIONIC TREE AND IRON DEFICIENCY ANEMIA OF GRAVIDAS. Iron 203-207 vimentin Homo sapiens 42-50 29021254-6 2017 Moreover, phospho-deficient OGT (S20A) cells attenuated cellular O-GlcNAcylation levels and also reduced phosphorylation of Ser-71 in the cytoskeletal protein vimentin, a modification critical for severing vimentin filament during cytokinesis. Serine 124-127 vimentin Homo sapiens 159-167 29229873-7 2017 TQ also inhibited cell migration ability of the gastric cancer cells and down-regulated the expression of the mesenchymal genes such as N-cadherin, Vimentin, and TWIST. thymoquinone 0-2 vimentin Homo sapiens 148-156 29344218-14 2017 ATRA treatment decreased the expression of phosphorylated (p-)beta-catenin, p-GSK-3beta, vimentin, and fibronectin, and increased the expression of NIS and E-cadherin, compared with the control. Tretinoin 0-4 vimentin Homo sapiens 89-97 29095858-8 2017 Supporting a role for PLA2 in psychosine-induced cell death of oligodendrocytes and astrocytes, the results show inhibition of PLA2 attenuates psychosine-induced decrease in the expression of astrocyte marker vimentin as well as myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and the neuronal marker SMI-32 in organotypic slice cultures. Psychosine 143-153 vimentin Homo sapiens 209-217 29096715-7 2017 RESULTS: 17beta-estradiol at 1 muM downregulated vimentin and CD13 and upregulated cytokeratin and CD9 proteins, promoting the differentiation of WJ-MSCs into EEC-like cells in the coculture system. Estradiol 9-25 vimentin Homo sapiens 49-57 29096715-8 2017 8-Br-cAMP at 0.5 mM upregulated vimentin and CD13 and downregulated CK and CD9, promoting the differentiation of WJ-MSCs into ESC-like cells. 8-Bromo Cyclic Adenosine Monophosphate 0-9 vimentin Homo sapiens 32-40 28274095-10 2017 An extracellular signal-regulated kinase inhibitor, PD98059, significantly suppressed the secretion of TSP-1, expressions of N-cadherin and vimentin, and decrease of E-cadherin in MCF10A cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 vimentin Homo sapiens 140-148 29201165-11 2017 In addition, MgCl2 and ZnCl2 treatment induced cytoskeleton remodeling and stimulated EMT via activation of the Wnt/beta-catenin signaling pathway, characterized by a decrease in E-cadherin and increases in N-cadherin, vimentin and Snail. Magnesium Chloride 13-18 vimentin Homo sapiens 219-227 29201165-11 2017 In addition, MgCl2 and ZnCl2 treatment induced cytoskeleton remodeling and stimulated EMT via activation of the Wnt/beta-catenin signaling pathway, characterized by a decrease in E-cadherin and increases in N-cadherin, vimentin and Snail. zinc chloride 23-28 vimentin Homo sapiens 219-227 28901475-4 2017 In the present study, it was demonstrated that in the RCC cell lines 786-O and Caki-1 treated with VPA, the neural (N)-cadherin, vimentin and SMAD4 protein and mRNA levels were decreased, accompanied with an increase in expression of epithelial (E)-cadherin. Valproic Acid 99-102 vimentin Homo sapiens 129-137 29048639-5 2017 Although dabrafenib-resistant cells exhibited increased cell motility and E-cadherin/vimentin reorganization, as expected in EMT, all of them showed unvaried E-cadherin mRNA and unchanged Snail protein levels, while Twist1 protein expression was decreased with the exception of A375 dabrafenib-resistant melanoma cells, where it was unaffected. dabrafenib 9-19 vimentin Homo sapiens 85-93 28906008-8 2017 Immunoblot and immunofluorescence analyses revealed that H2 O2 upregulated the expression of alpha-SMA and vimentin and downregulated that of ZO-1 and N-cadherin. Hydrogen Peroxide 57-62 vimentin Homo sapiens 107-115 28898551-2 2017 Vimentin and desmin possess N-acetyl-d-glucosamine (GlcNAc)-binding properties on cell surfaces. Acetylglucosamine 28-50 vimentin Homo sapiens 0-8 29113242-4 2017 Besides the anti-inflammatory function of eupatolide, the present study found that eupatolide suppressed the migration and invasion of breast cancer cells, which was associated with the downregulation of vimentin in MDA-MB-231 cells and the upregulation of E-cadherin in MCF-7 cells. eupatolide 83-93 vimentin Homo sapiens 204-212 28898551-2 2017 Vimentin and desmin possess N-acetyl-d-glucosamine (GlcNAc)-binding properties on cell surfaces. Acetylglucosamine 52-58 vimentin Homo sapiens 0-8 28898551-6 2017 The small GlcNAc-bearing polymers strongly interacted with HeLa cells through vimentin expressed on the cell surface and interacted with vimentin-, desmin-, GFAP- and peripherin-transfected vimentin-deficient HeLa cells. Acetylglucosamine 10-16 vimentin Homo sapiens 78-86 28898551-6 2017 The small GlcNAc-bearing polymers strongly interacted with HeLa cells through vimentin expressed on the cell surface and interacted with vimentin-, desmin-, GFAP- and peripherin-transfected vimentin-deficient HeLa cells. Acetylglucosamine 10-16 vimentin Homo sapiens 137-145 28898551-6 2017 The small GlcNAc-bearing polymers strongly interacted with HeLa cells through vimentin expressed on the cell surface and interacted with vimentin-, desmin-, GFAP- and peripherin-transfected vimentin-deficient HeLa cells. Acetylglucosamine 10-16 vimentin Homo sapiens 137-145 28898551-6 2017 The small GlcNAc-bearing polymers strongly interacted with HeLa cells through vimentin expressed on the cell surface and interacted with vimentin-, desmin-, GFAP- and peripherin-transfected vimentin-deficient HeLa cells. Polymers 25-33 vimentin Homo sapiens 78-86 28898551-6 2017 The small GlcNAc-bearing polymers strongly interacted with HeLa cells through vimentin expressed on the cell surface and interacted with vimentin-, desmin-, GFAP- and peripherin-transfected vimentin-deficient HeLa cells. Polymers 25-33 vimentin Homo sapiens 137-145 28898551-6 2017 The small GlcNAc-bearing polymers strongly interacted with HeLa cells through vimentin expressed on the cell surface and interacted with vimentin-, desmin-, GFAP- and peripherin-transfected vimentin-deficient HeLa cells. Polymers 25-33 vimentin Homo sapiens 137-145 28972876-4 2017 Here we established a doxorubicin-resistant breast cancer cell line MCF-7/Adr, and found these cells exhibited an EMT phenotype featured by a fibroblast-like morphology, increased the capacity of migration and invasion, and underwent the changes of molecular markers of EMT including E-cadherin, N-cadherin, and vimentin. Doxorubicin 22-33 vimentin Homo sapiens 312-320 28760545-0 2017 Reactive carbonyl compounds impair wound healing by vimentin collapse and loss of the primary cilium. reactive carbonyl compounds 0-27 vimentin Homo sapiens 52-60 28980000-5 2017 The intensity of QUIN+ expression on CD39+ microglia and VIM+ Muller cells was greatly increased in both human T1D and T2D retinas. Quinolinic Acid 17-22 vimentin Homo sapiens 57-60 28765898-9 2017 Additionally, cross-species comparison of amino acid sequence alignment of vimentin, as well as site-directed mutagenesis, revealed that one residue, the asparagine at position 417, is critical for antibody binding. Asparagine 154-164 vimentin Homo sapiens 75-83 28765898-10 2017 Using smaller vimentin fragments ranging in length from 9 to 13 residues, each containing this critical asparagine, we determined that the minimal residues required for V9 mAb recognition of human vimentin are the thirteen amino acid residues at positions 411-423 (411ISLPLPNFSSLNL423). Asparagine 104-114 vimentin Homo sapiens 197-205 28791412-4 2017 BaP also induced upregulation of the mesenchymal markers N-cadherin and vimentin and downregulation of the epithelial marker E-cadherin. Benzo(a)pyrene 0-3 vimentin Homo sapiens 72-80 28791412-5 2017 When the expression of Twist1 was knocked down in A549 cells that were treated with BaP for 4 weeks (A549BaP-4w), the expression of Twist1 decreased, which inhibited the migration capacity of A549BaP-4w cells, the expression of N-cadherin and vimentin was downregulated and the expression of E-cadherin was upregulated. Benzo(a)pyrene 84-87 vimentin Homo sapiens 243-251 28926892-15 2017 Western blot results indicated that treated with silibinin alone or in combination of crozitinib for 48 hours, the protein level of E-cadherin in H2228 cells was upregulated, while the expressions of p-ALK and vimentin were downregulated, without obvious alteration of ALK protein expression. Silybin 49-58 vimentin Homo sapiens 210-218 28926892-15 2017 Western blot results indicated that treated with silibinin alone or in combination of crozitinib for 48 hours, the protein level of E-cadherin in H2228 cells was upregulated, while the expressions of p-ALK and vimentin were downregulated, without obvious alteration of ALK protein expression. crozitinib 86-96 vimentin Homo sapiens 210-218 28716733-6 2017 ML327 induced protein expression changes, increased E-cadherin and decreased vimentin, consistent with partial induction of mesenchymal-to-epithelial transition in multiple Ewing Sarcoma cell lines (SK-N-MC, TC71, and ES-5838). ML327 0-5 vimentin Homo sapiens 77-85 28733035-5 2017 Moreover, high glucose levels induced Notch2 expression, which promoted EndMT, resulting in the downregulation of vascular endothelial cadherin and CD31 and upregulation of fibroblast-specific protein-1, alpha-smooth muscle actin, fibronectin, and vimentin. Glucose 15-22 vimentin Homo sapiens 248-256 28791619-3 2017 Western blot revealed increased protein level of vimentin following CCI, peaking at 7 days. CCI 68-71 vimentin Homo sapiens 49-57 28810525-8 2017 Osthole significantly up-regulated epithelial biomarkers (E-cadherin and beta-catenin) and down-regulated mesenchymal biomarkers (N-cadherin and vimentin). osthol 0-7 vimentin Homo sapiens 145-153 29270529-11 2017 Vimentin is a lipid droplet-associated protein, and changes in its expression may impair fatty acid storage/mobilization in adipose tissue, whereas high levels of AMBP may reflect oxidative stress. Fatty Acids 89-99 vimentin Homo sapiens 0-8 28743511-10 2017 Suppression of Raf-1 or CK2 by its inhibitor (GW5074 or TBB) blocked vimentin phosphorylation, remodeling and endothelial apoptosis, and preserved cell viability in TNF-alpha-induced HUVECs. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone 46-52 vimentin Homo sapiens 69-77 28743511-10 2017 Suppression of Raf-1 or CK2 by its inhibitor (GW5074 or TBB) blocked vimentin phosphorylation, remodeling and endothelial apoptosis, and preserved cell viability in TNF-alpha-induced HUVECs. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate 56-59 vimentin Homo sapiens 69-77 28900489-13 2017 E-cadherin expression was increased and vimentin expression was decreased after silencing of Rac3 or following the treatment of LY2228820. ralimetinib 128-137 vimentin Homo sapiens 40-48 28605700-11 2017 Significantly downregulated canonical Wnt signaling proteins and marker of epithelial-mesenchymal transition (EMT), vimentin were observed in cells treated with resveratrol-salinomycin combination. Resveratrol 161-172 vimentin Homo sapiens 116-124 28605700-11 2017 Significantly downregulated canonical Wnt signaling proteins and marker of epithelial-mesenchymal transition (EMT), vimentin were observed in cells treated with resveratrol-salinomycin combination. salinomycin 173-184 vimentin Homo sapiens 116-124 29165508-6 2017 The limit of detection of Xpert Carba-R was different for each carbapenemasa: 40.8 ufc/reaction to KPC and NDM and 30.6 ufc/reaction to VIM. carba-r 33-40 vimentin Homo sapiens 137-140 29088842-12 2017 2HF also decreased the mesenchymal markers vimentin and fibronectin along with causing a parallel increase in pro-differentiation protein E-cadherin. 2'-hydroxyflavanone 0-3 vimentin Homo sapiens 43-51 28861152-6 2017 Notably, the EMT marker E-cadherin or vimentin was also upregulated or downregulated upon miR-138 overexpression, and these effects were restored by SOX4 overexpression. mir-138 90-97 vimentin Homo sapiens 38-46 28774312-9 2017 Consequently, wogonoside could down-regulate MMP-9, MMP-2, vimentin and CD44v6 expression in TNF-alpha-induced MDA-MB-231 and MDA-MB-435 cells. wogonoside 14-24 vimentin Homo sapiens 59-67 27866306-3 2017 Our present study revealed that nanomolar concentrations of BPA can significantly increase the proliferation, migration and invasion of NB SH-SY5Y and SiMa cells, further evidenced by the upregulation of human proliferating cell nuclear antigen, Bcl-2, vimentin and fibronectin. bisphenol A 60-63 vimentin Homo sapiens 253-261 28627650-5 2017 When treated with doxorubicin, MCF-7 cells displayed characteristics of EMT, such as, mesenchymal markers (vimentin and fibronectin) and EMT-related transcription factors (Slug and Snail-1) in their RNA expression. Doxorubicin 18-29 vimentin Homo sapiens 107-115 28798691-7 2017 In this study, we found that fentanyl induced stemness and EMT in MCF-7 and MDA-MB-231 breast cancer cells by analysis of sphere formation, expression of stemness markers (Sox2, Oct4) and EMT markers (N-cadherin, E-cadherin and Vimentin). Fentanyl 29-37 vimentin Homo sapiens 228-236 28761361-7 2017 Western blot showed that circ-104916 overexpression upregulated E-cadherin and downregulated N-cadherin, Vimentin and Slug, indicating that circ-104916 was involved in the epithelial-mesenchymal transition process. circ 25-29 vimentin Homo sapiens 105-113 28761361-7 2017 Western blot showed that circ-104916 overexpression upregulated E-cadherin and downregulated N-cadherin, Vimentin and Slug, indicating that circ-104916 was involved in the epithelial-mesenchymal transition process. circ 140-144 vimentin Homo sapiens 105-113 28611349-7 2017 Kaplan-Meier survival analysis indicated that vimentin expression could stratify the CSS and DFS of patients with stage II CRC at high risk (p=0.029, p=0.042, respectively), but not those of low-risk stage II patients (p=0.208, p=0.361, respectively). thiocysteine 85-88 vimentin Homo sapiens 46-54 28385482-5 2017 In our study, we found that nicotine could accelerate HeLa cells migration and invasion, activate PI3K/Akt and NF-kappaB pathways and increase the expression of Vimentin in vitro. Nicotine 28-36 vimentin Homo sapiens 161-169 28385482-6 2017 Moreover, we demonstrated that the specific PI3K inhibitor LY294002 could reverse nicotine-induced cell migration and invasion, NF-kappaB activation and up-regulation of Vimentin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 59-67 vimentin Homo sapiens 170-178 28385482-6 2017 Moreover, we demonstrated that the specific PI3K inhibitor LY294002 could reverse nicotine-induced cell migration and invasion, NF-kappaB activation and up-regulation of Vimentin. Nicotine 82-90 vimentin Homo sapiens 170-178 28385482-7 2017 Inhibition of NF-kappaB by Pyrrolidine dithiocarbamate (PDTC) also antagonized nicotine-induced cell migration, invasion and up-regulation of Vimentin. pyrrolidine dithiocarbamic acid 27-54 vimentin Homo sapiens 142-150 28385482-7 2017 Inhibition of NF-kappaB by Pyrrolidine dithiocarbamate (PDTC) also antagonized nicotine-induced cell migration, invasion and up-regulation of Vimentin. pyrrolidine dithiocarbamic acid 56-60 vimentin Homo sapiens 142-150 28385482-7 2017 Inhibition of NF-kappaB by Pyrrolidine dithiocarbamate (PDTC) also antagonized nicotine-induced cell migration, invasion and up-regulation of Vimentin. Nicotine 79-87 vimentin Homo sapiens 142-150 28450285-0 2017 Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentin. Cadmium 9-16 vimentin Homo sapiens 100-108 28450285-3 2017 We aimed to evaluate whether low-dose Cd exposure induces vimentin phosphorylation and Yes-associated protein 1 (YAP1) activation leading to peribronchiolar fibrosis and subsequent airway remodeling. Cadmium 38-40 vimentin Homo sapiens 58-66 28450285-7 2017 In parallel, Cd induces AKT and cdc2 phosphorylation and downstream vimentin phosphorylation at Ser39 and Ser55, respectively. Cadmium 13-15 vimentin Homo sapiens 68-76 28450285-8 2017 AKT and cdc2 inhibitors block Cd-induced vimentin fragmentation and secretion in association with inhibition of alpha-SMA expression, ECM deposition, and collagen secretion. Cadmium 30-32 vimentin Homo sapiens 41-49 28450285-9 2017 Furthermore, vimentin silencing abrogates Cd-induced alpha-SMA expression and decreases ECM production. Cadmium 42-44 vimentin Homo sapiens 13-21 28450285-11 2017 These findings identify two specific sites on vimentin that are phosphorylated by Cd and highlight the functional significance of vimentin phosphorylation in YAP1/Smad3 signaling that mediates Cd-induced peribronchiolar fibrosis and airway remodeling. Cadmium 82-84 vimentin Homo sapiens 46-54 28450285-11 2017 These findings identify two specific sites on vimentin that are phosphorylated by Cd and highlight the functional significance of vimentin phosphorylation in YAP1/Smad3 signaling that mediates Cd-induced peribronchiolar fibrosis and airway remodeling. Cadmium 193-195 vimentin Homo sapiens 46-54 28450285-11 2017 These findings identify two specific sites on vimentin that are phosphorylated by Cd and highlight the functional significance of vimentin phosphorylation in YAP1/Smad3 signaling that mediates Cd-induced peribronchiolar fibrosis and airway remodeling. Cadmium 193-195 vimentin Homo sapiens 130-138 28183721-2 2017 Since smoking can modify proteins by carbamylation (formation of homocitrulline), this study was conducted to investigate these effects on vimentin in animal models and RA. homocitrulline 65-79 vimentin Homo sapiens 139-147 28693210-8 2017 The patient was positive for vimentin expression and refractory to etoposide and cisplatin chemotherapy, and succumbed to the disease 18 months after diagnosis. Etoposide 67-76 vimentin Homo sapiens 29-37 28693210-8 2017 The patient was positive for vimentin expression and refractory to etoposide and cisplatin chemotherapy, and succumbed to the disease 18 months after diagnosis. Cisplatin 81-90 vimentin Homo sapiens 29-37 28509438-10 2017 To investigate whether deguelin induced EMT by regulating NEK2, we overexpressed NEK2 in both NCI-H520 and SK-MES-1 cell lines, and then used real time-PCR to study the E-cadherin and Vimentin messenger RNA expression in both NSCLC cells. deguelin 23-31 vimentin Homo sapiens 184-192 28381667-7 2017 Treatment with arachidonic acid in epithelial cells increased VIM and TWIST1 expressions without decrease of CDH1 expression, while TGFbeta1 decreased CDH1 and increased VIM and TWIST1; more importantly, TGFbeta1 induced the expression of PLCG2, but arachidonic acid did not induce the expression of TGFB1. Arachidonic Acid 15-31 vimentin Homo sapiens 62-65 28381667-8 2017 Finally, arachidonic acid accelerated the TGFbeta1 increasing VIM and TWIST1 expressions, meanwhile arachidonic acid synthase inhibitor partially blocked the TGFbeta1 increasing VIM and TWIST1 expressions. Arachidonic Acid 9-25 vimentin Homo sapiens 62-65 28489600-8 2017 Knocking down vimentin also repressed oleate-induced HNSCC invasion. Oleic Acid 38-44 vimentin Homo sapiens 14-22 28401486-10 2017 These decreases were followed by the suppression of GMT through a reduction of beta3 integrin, MMP-2, MMP-9, Slug and vimentin expression via inactivation of PI3K/AKT signaling. GlcNAc-Mal 52-55 vimentin Homo sapiens 118-126 28527916-8 2017 Furthermore, enhanced expressions of integrins alpha5 and beta1, paxillin, and vimentin indicated that prolonged Cd treatment reorganized the cytoskeleton, which aided malignancy, as evidenced by enhanced matrix metalloprotease 2/9 (MMP2/9) secretion and cell invasion. Cadmium 113-115 vimentin Homo sapiens 79-87 28302679-4 2017 Enzalutamide treatment significantly enhanced the expression of EMP drivers (ZEB1, ZEB2, Snail, Twist, and FOXC2) and mesenchymal markers (N-cadherin, fibronectin, and vimentin) in prostate cancer cells, enhanced prostate cancer cell migration, and induced prostate cancer transformation to a spindle, fibroblast-like morphology. enzalutamide 0-12 vimentin Homo sapiens 168-176 28570699-6 2017 Conversely, positive N-cadherin and higher Vimentin expression levels were associated with poor DSS and disease-free survival. dss 96-99 vimentin Homo sapiens 43-51 28570699-7 2017 Notably, our multivariate Cox regression model indicated that high Vimentin expression was an adverse prognostic factor for DSS in TSCC patients, even after the adjustment for cell differentiation, pathological stage, and expression levels of Snail, Twist, E-cadherin, and N-cadherin. dss 124-127 vimentin Homo sapiens 67-75 28402270-11 2017 PD98059, a specific inhibitor of the activation of MEK, blocked the migration and invasion by inhibiting the expression of MMP2 and vimentin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 vimentin Homo sapiens 132-140 28322794-0 2017 Involvement of vimentin in neurite outgrowth damage induced by fipronil in SH-SY5Y cells. fipronil 63-71 vimentin Homo sapiens 15-23 29156697-8 2017 Western blot analysis and qRT-PCR results showed that brusatol significantly down-regulated the expression of vimentin and Twist, and markedly stimulated the expression of E-cadherin, the key regulatory factors of the epithelial-mesenchymal transition process. brusatol 54-62 vimentin Homo sapiens 110-118 28322794-6 2017 Interestingly using proteomics, we identified vimentin to be dramatically expressed by SH-SY5Y cells as a response to fipronil treatment. fipronil 118-126 vimentin Homo sapiens 46-54 28322794-9 2017 However at high concentrations of fipronil, vimentin was found in less defined fibrils, in bridge-like formation, and dense surrounding vacuoles. fipronil 34-42 vimentin Homo sapiens 44-52 28322794-10 2017 In all, our results indicate that vimentin plays an important role in fipronil-induced neurotoxicity in SH-SY5Y cells. fipronil 70-78 vimentin Homo sapiens 34-42 28476800-11 2017 However, levels of proliferating cell nuclear antigen (PCNA) and vimentin (VIM) marginally decreased in Dox-treated clones. Doxorubicin 104-107 vimentin Homo sapiens 65-73 28476800-11 2017 However, levels of proliferating cell nuclear antigen (PCNA) and vimentin (VIM) marginally decreased in Dox-treated clones. Doxorubicin 104-107 vimentin Homo sapiens 75-78 31994108-6 2017 RESULTS: C-PC suppressed the EMT as assessed by reduced expression of vimentin, type-1-collagen and fibronectin, and increased E-cadherin expression in TGF-beta1 treated cells. Phycocyanin 9-13 vimentin Homo sapiens 70-78 28318921-9 2017 RESULTS: In non-induced co-cultures, BMSC were able to suppress Vimentin in PCI-13 as a marker of tumor transition. pci-13 76-82 vimentin Homo sapiens 64-72 28284859-5 2017 The data showed that PCB126, exposing both Bel-7402 and SMMC-7721 cells for 48h, promoted EMT that was demonstrated by E-cadherin repression, up-regulation of N-cadherin and vimentin, and morphological alteration. 3,4,5,3',4'-pentachlorobiphenyl 21-27 vimentin Homo sapiens 174-182 28284859-6 2017 We found that signal transducer and activator of transcription 3 (STAT3)/Snail1 signaling was activated after PCB126 exposure, and the addition of STAT3 inhibitor WP1066 blocked PCB126-induced down-regulation of E-cadherin as well as up-regulation of N-cadherin and vimentin. 3,4,5,3',4'-pentachlorobiphenyl 178-184 vimentin Homo sapiens 266-274 28284859-7 2017 Moreover, PCB126 exposure increased pyruvate kinase M2 (PKM2) expression and its nuclear translocation, whereas treatment with PKM2 shRNA suppressed the activation of STAT3/Snail1 signaling and the alternation of EMT-related molecules (E-cadherin, N-cadherin and vimentin). 3,4,5,3',4'-pentachlorobiphenyl 10-16 vimentin Homo sapiens 263-271 29082698-8 2017 Compared with model group, Glehniae Radix petroleum ether part group could effectively inhibit mRNA expressions of ColI,Vimentin and alpha-SMA, but improve expression of E-cadherin.Glehniae Radix petroleum ether part could reduce the content of hydroxyproline in cells and inhibit the migration of A549 cells.Therefore, the petroleum ether extract of Glehniae Radix can effectively inhibit the occurrence of epithelial mesenchymal transition induced by TGF-beta1 induced alveolar epithelial cells, and Glehniae Radix petroleum ether part may be a potential drug for idiopathic pulmonary fibrosis. naphtha 42-57 vimentin Homo sapiens 120-128 29082698-8 2017 Compared with model group, Glehniae Radix petroleum ether part group could effectively inhibit mRNA expressions of ColI,Vimentin and alpha-SMA, but improve expression of E-cadherin.Glehniae Radix petroleum ether part could reduce the content of hydroxyproline in cells and inhibit the migration of A549 cells.Therefore, the petroleum ether extract of Glehniae Radix can effectively inhibit the occurrence of epithelial mesenchymal transition induced by TGF-beta1 induced alveolar epithelial cells, and Glehniae Radix petroleum ether part may be a potential drug for idiopathic pulmonary fibrosis. glehniae radix petroleum ether 27-57 vimentin Homo sapiens 120-128 28496332-0 2017 Epithelial-to-mesenchymal transition correlates with gefitinib resistance in NSCLC cells and the liver X receptor ligand GW3965 reverses gefitinib resistance through inhibition of vimentin. Gefitinib 137-146 vimentin Homo sapiens 180-188 28496332-6 2017 Compared with the sensitive parental cell line, HCC827, vimentin expression levels were increased in HCC827 cells with acquired gefitinib resistance. Gefitinib 128-137 vimentin Homo sapiens 56-64 28496332-7 2017 Vimentin expression was also markedly upregulated in cells with intrinsic gefitinib resistance, and upregulated vimentin expression was correlated with gefitinib sensitivity. Gefitinib 74-83 vimentin Homo sapiens 0-8 28496332-7 2017 Vimentin expression was also markedly upregulated in cells with intrinsic gefitinib resistance, and upregulated vimentin expression was correlated with gefitinib sensitivity. Gefitinib 152-161 vimentin Homo sapiens 112-120 28496332-9 2017 Therefore, we investigated the relationship among GW3965, vimentin, and gefitinib resistance in NSCLC cells by analysis of the expression of vimentin in cells treated with a combination of gefitinib and GW3965. Gefitinib 189-198 vimentin Homo sapiens 141-149 28496332-9 2017 Therefore, we investigated the relationship among GW3965, vimentin, and gefitinib resistance in NSCLC cells by analysis of the expression of vimentin in cells treated with a combination of gefitinib and GW3965. GW 3965 203-209 vimentin Homo sapiens 141-149 28496332-10 2017 Gefitinib treatment led to increased levels of intracellular vimentin, while combined treatment with gefitinib and GW3965 resulted in decreased vimentin expression levels through reduction of gefitinib drug resistance in NSCLC cells. Gefitinib 0-9 vimentin Homo sapiens 61-69 28496332-10 2017 Gefitinib treatment led to increased levels of intracellular vimentin, while combined treatment with gefitinib and GW3965 resulted in decreased vimentin expression levels through reduction of gefitinib drug resistance in NSCLC cells. Gefitinib 101-110 vimentin Homo sapiens 144-152 28496332-10 2017 Gefitinib treatment led to increased levels of intracellular vimentin, while combined treatment with gefitinib and GW3965 resulted in decreased vimentin expression levels through reduction of gefitinib drug resistance in NSCLC cells. GW 3965 115-121 vimentin Homo sapiens 144-152 28496332-11 2017 Overall, these findings suggest that vimentin expression is associated with sensitivity to gefitinib, and our study highlights the potential usefulness of the drug, GW3965, for reversal of gefitinib resistance through inhibition of vimentin expression. Gefitinib 91-100 vimentin Homo sapiens 37-45 28938541-8 2017 In contrast, high levels of decoy receptor for IL-1, sIL-1RII, and a high tissue vimentin/E-cadherin ratio were associated with a poor OS (HR=3.78; p=0.00055) in the erlotinib cohort. Erlotinib Hydrochloride 166-175 vimentin Homo sapiens 81-89 28438134-10 2017 An immunofluorescence assay and enzyme-linked immunosorbent assay (ELISA) also revealed that poly I:C decreased E-cadherin protein levels and increased vimentin protein levels, and anti-IL-8 antibody reversed this effect. Poly I-C 93-101 vimentin Homo sapiens 152-160 28404892-4 2017 Gambogic acid also increased the mRNA and protein expression of E-cadherin, but repressed the mRNA and protein expression of N-cadherin, vimentin, and transcription factor TWIST1. gambogic acid 0-13 vimentin Homo sapiens 137-145 28384185-0 2017 Evaluation of a modified meropenem hydrolysis assay on a large cohort of KPC and VIM carbapenemase-producing Enterobacteriaceae. Meropenem 25-34 vimentin Homo sapiens 81-84 28384185-5 2017 The MHA was successfully applied to detect carbapenemase activity in 981 well-characterized Enterobacteriaceae strains producing KPC or VIM carbapenemases, and in 146 carbapenem fully susceptible strains. Carbapenems 43-53 vimentin Homo sapiens 136-139 28150354-0 2017 TET1 promotes cisplatin-resistance via demethylating the vimentin promoter in ovarian cancer. Cisplatin 14-23 vimentin Homo sapiens 57-65 28150354-10 2017 Thus, TET1 expression causes resistance to cisplatin and one of the targets of TET1 action is vimentin in ovarian cancer. Cisplatin 43-52 vimentin Homo sapiens 94-102 28413487-6 2017 Furthermore, co-treatment with vandetanib and an ADAM10 inhibitor (GI254023X) or ADAM17 inhibitor (Marimastat) synergistically prevented migration and the expression of vimentin, Snail and alpha-smooth muscle actin by regulating extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. vandetanib 31-41 vimentin Homo sapiens 169-177 28413487-6 2017 Furthermore, co-treatment with vandetanib and an ADAM10 inhibitor (GI254023X) or ADAM17 inhibitor (Marimastat) synergistically prevented migration and the expression of vimentin, Snail and alpha-smooth muscle actin by regulating extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. 3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide 67-76 vimentin Homo sapiens 169-177 28114394-10 2017 Of these, 3 proteins (vimentin, tubulin and alpha-actinin-4) were identified using both 1D-SDS-PAGE and 2D-DIGE. 1d-sds 88-94 vimentin Homo sapiens 22-30 28350122-9 2017 Berberine inhibited transforming growth factor-beta (TGF-beta)-induced tumor invasion and suppressed epithelial-to-mesenchymal transition (EMT) process, as evidenced by increased E-cadherin and decreased vimentin proteins. Berberine 0-9 vimentin Homo sapiens 204-212 28358024-8 2017 Similar results were observed for DADS-induced changes in the expression of vimentin, CD34, Ki-67, and E-cadherin in xenografted tumors. diallyl disulfide 34-38 vimentin Homo sapiens 76-84 28043910-3 2017 In this study, we demonstrated that metformin is capable of inhibiting prostate cancer cell migration and invasion by repressing EMT evidenced by downregulating the mesenchymal markers N-cadherin, Vimentin, and Twist and upregulating the epithelium E-cadherin. Metformin 36-45 vimentin Homo sapiens 197-205 28262738-7 2017 Concomitantly, high glucose increased global O-GlcNAcylated proteins, the expressions of vimentin, hexokinase, glucosamine-fructose-6-phosphate amidotransferase (GFAT) and O-GlcNAc transferase of CCA cells. Glucose 20-27 vimentin Homo sapiens 89-97 28262738-8 2017 The glucose level that promoted migration/invasion was shown to be potentiated by the induction of GFAT, O-GlcNAcylation and an increase of O-GlcNAcylated vimentin and vimentin expression. Glucose 4-11 vimentin Homo sapiens 155-163 28262738-8 2017 The glucose level that promoted migration/invasion was shown to be potentiated by the induction of GFAT, O-GlcNAcylation and an increase of O-GlcNAcylated vimentin and vimentin expression. Glucose 4-11 vimentin Homo sapiens 168-176 28262738-10 2017 Altogether, these results suggested the role of high glucose enhanced CCA metastasis via modulation of O-GlcNAcylation, through the expressions of GFAT and vimentin. Glucose 53-60 vimentin Homo sapiens 156-164 27887793-4 2017 The disassembling effect of quercetin on microfilaments, microtubules and vimentin filaments along with its inhibitory impact on vimentin and N-cadherin expression might account for the decreased migration of A549 cells in response to quercetin treatment. Quercetin 28-37 vimentin Homo sapiens 74-82 27887793-4 2017 The disassembling effect of quercetin on microfilaments, microtubules and vimentin filaments along with its inhibitory impact on vimentin and N-cadherin expression might account for the decreased migration of A549 cells in response to quercetin treatment. Quercetin 28-37 vimentin Homo sapiens 129-137 28056339-5 2017 Using a series of experiments, we found that asbestos induces a fibroblastic transition of mesothelial cells with a gain of mesenchymal markers (vimentin and N-cadherin), whereas epithelial markers, such as E-cadherin, are down-regulated. Asbestos 45-53 vimentin Homo sapiens 145-153 27496082-7 2017 Expression of the fibrotic markers vimentin, fibronectin, and alpha-smooth muscle actin was more elevated in biopsy specimens from DDs at 4 months than in those from LDs. Fumigant 93 131-134 vimentin Homo sapiens 35-43 27580587-4 2017 We find that CD significantly increases expression of the epithelial marker E-cadherin, while reciprocally decreasing expression of mesenchymal markers such as snail, slug, and vimentin in BT-549 cells. cardamonin 13-15 vimentin Homo sapiens 177-185 28351321-6 2017 We demonstrate that temsirolimus and torin 1 effectively reduced the constitutive as well as phorbol-myristate-acetate/oncostatin-M-induced expression of mesenchymal markers (fibronectin, vimentin, and YKL40) and neural stem cell markers (Sox2, Oct4, nestin, and mushashi1). Tetradecanoylphorbol Acetate 93-118 vimentin Homo sapiens 188-196 28000897-9 2017 Moreover, while Slug, MMP9, MMP2, CD44, N-cadherin and vimentin, the mesenchymal cell markers, were repressed by bortezomib concomitant increased expression of E-cadherin was observed. Bortezomib 113-123 vimentin Homo sapiens 55-63 29441859-7 2017 Moreover, E-cadherin and vimentin expressions were more positive in the IM and AZM group than in the other groups. Azithromycin 79-82 vimentin Homo sapiens 25-33 27752740-7 2017 A 6-h incubation with the proteasome inhibitor MG-132 fully rescued vimentin from AHR-mediated proteasomal degradation. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 47-53 vimentin Homo sapiens 68-76 28260043-8 2017 The results showed that HepG2/DOX cells acquired EMT characteristics, with a decreased expression level of E-cadherin and an enhanced expression level of vimentin, and possessed high migratory abilities and invasiveness. Doxorubicin 30-33 vimentin Homo sapiens 154-162 28452702-7 2017 Increased expression of mesenchymal markers, including vimentin, alpha-smooth muscle actin, and fibronectin in TGF beta 1 induced A549 cells were downregulated by doxycycline treatment. Doxycycline 163-174 vimentin Homo sapiens 55-63 28361849-5 2017 RESULTS: The prolonged exposure (up to 30 days) of colon cancer cells to low-dose ACD (0.2-0.5 microg/ml cisplatin and 0.1-0.2 microg/ml irinotecan) in combination with IFN (500-1000 IU/ml) led to 37-fold decreased colony-forming activity of these cell and 10-fold reduction of the number of cells expressing mesenchymal protein markers (N-cadherin, vimentin). acid citrate dextrose 82-85 vimentin Homo sapiens 350-358 28184928-7 2017 Finally, we demonstrated that osthole inhibited epithelial-mesenchymal transition (EMT) via increasing the expression of epithelial biomarkers E-cadherin and beta-catenin, and significantly decreasing mesenchymal N-cadherin and vimentin protein expression. osthol 30-37 vimentin Homo sapiens 228-236 28280366-6 2017 The western blot assay showed that salinomycin could increase the expression of epithelial markers (E-cadherin and Keratin) while decrease the expression of mesenchymal markers (N-cadherin and vimentin) in a dose-dependent manner. salinomycin 35-46 vimentin Homo sapiens 193-201 28102337-10 2017 Moreover, GPi DBS may be used as a supplementary treatment when initial Vim DBS fails to control MDS symptoms. gpi dbs 10-17 vimentin Homo sapiens 72-75 28138219-6 2017 We found that resveratrol suppressed the decrease of zona occludens-1 (ZO-1) and caused an increase of alpha-smooth muscle actin expression in TGF-beta2-treated ARPE-19 cells, assessed using Western blots; moreover, it also suppressed the decrease in ZO-1 and the increase of vimentin expression, observed using immunocytochemistry. Resveratrol 14-25 vimentin Homo sapiens 276-284 27856280-4 2017 In our study, we observed that MC-LR treatment decreased epithelial marker E-cadherin expression and up-regulated the levels of mesenchymal markers Vimentin and Snail in colorectal cancer cells. cyanoginosin LR 31-36 vimentin Homo sapiens 148-156 28011480-6 2017 In contrast, treatment with CaLa (2.5 mM), alone and in combination with 5-FU, exerted antitumor activity against both anchored and unanchored CRC cells via calcium-mediated FAK proteolysis and inhibition of EMT markers, such as vimentin and SNAIL. Fluorouracil 73-77 vimentin Homo sapiens 229-237 29762991-8 2017 Conversely,after U0126 treatment,the expression levels of p-ERK1 /2,c-Myc and vimentin decreased significantly,while E-cadherin expression level increased. U 0126 17-22 vimentin Homo sapiens 78-86 28849534-8 2017 The results showed that taurine down-regulated the expression of N-cadherin, TWIST1, ZEB1, SNAIL, and vimentin. Taurine 24-31 vimentin Homo sapiens 102-110 27671303-5 2017 AZM475271 but not another Src inhibitor, SU6656, partially relieved the suppressive effect of TGF-beta1 on E-cadherin and inhibited TGF-beta1-induced upregulation of the MMP2, MMP9, N-cadherin and vimentin genes, activity of a TGF-beta1-dependent reporter gene, and activation of Smad2 and Smad3. AZM475271 0-9 vimentin Homo sapiens 197-205 27829579-7 2017 When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin. Curcumin 47-55 vimentin Homo sapiens 164-172 27829579-7 2017 When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin. Curcumin 66-74 vimentin Homo sapiens 164-172 28011481-6 2017 A low dose of metformin significantly increased anoikis and inhibited migration/ invasion of CCA cells that was in concert with the decrease of vimentin, matrix metalloproteinase (MMP)-2 and -7. Metformin 14-23 vimentin Homo sapiens 144-152 29188873-7 2017 Furthermore, with the redistribution of f-actin, we observed an increase in the intermediate filament vimentin, compatible with the notion that vimentin may be increased due to its greater role in cytoskeletal dynamics during advancing population doubling levels (PDLs) and in response to a low-glucose exposure. Glucose 295-302 vimentin Homo sapiens 144-152 27932314-0 2017 TIS21/BTG2 inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade. Doxorubicin 20-31 vimentin Homo sapiens 53-61 27932314-0 2017 TIS21/BTG2 inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade. Reactive Oxygen Species 80-83 vimentin Homo sapiens 53-61 28050601-5 2017 Interestingly, the assembly of the vimentin microfibrils in MADB fibroblasts improved with rapamycin and dimethylsulfoxide. Sirolimus 91-100 vimentin Homo sapiens 35-43 28050601-5 2017 Interestingly, the assembly of the vimentin microfibrils in MADB fibroblasts improved with rapamycin and dimethylsulfoxide. Dimethyl Sulfoxide 105-122 vimentin Homo sapiens 35-43 28625142-11 2017 MG132 significantly suppressed TGFbeta-induced upregulation of alpha-SMA, fibronectin, and vimentin, as well as TGFbeta-induced cell migration. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 0-5 vimentin Homo sapiens 91-99 28123498-7 2017 The expression levels of alpha-SMA, vimentin and collagen I were significantly increased in HK-2 cells cultured under high glucose conditions, as compared with those cultured under normal glucose conditions (P<0.01). Glucose 123-130 vimentin Homo sapiens 36-44 28123498-10 2017 Allicin partially reversed the high-glucose-induced increase in alpha-SMA, vimentin and collagen I expression (P<0.01 at 20 microg/ml), increased the expression of E-cadherin, and significantly downregulated the high glucose-induced expression of TGF-beta1 and p-ERK1/2 in a dose-dependent manner (P<0.05). allicin 0-7 vimentin Homo sapiens 75-83 28123498-10 2017 Allicin partially reversed the high-glucose-induced increase in alpha-SMA, vimentin and collagen I expression (P<0.01 at 20 microg/ml), increased the expression of E-cadherin, and significantly downregulated the high glucose-induced expression of TGF-beta1 and p-ERK1/2 in a dose-dependent manner (P<0.05). Glucose 36-43 vimentin Homo sapiens 75-83 28744307-1 2017 OBJECTIVES: We aimed to explore the association between metformin treatment and epithelial-mesenchymal transition (EMT) phenotype and further appraise the prognostic values of metformin and EMT markers E-cadherin and vimentin for colorectal cancer (CRC) in clinical practice. Metformin 56-65 vimentin Homo sapiens 217-225 28042775-6 2017 RESULTS: There was a lower protein expression of ROCK-1, vimentin, CD44 and CD24 in both cell lines after treatment with metformin and Y27632. Metformin 121-130 vimentin Homo sapiens 57-65 28751821-3 2017 In view of the multiplicity of citrullinated autoantigens described as ACPA targets, we generated a multiepitope citrullinated peptide (Cit-ME) from the sequences of major citrullinated autoantigens: filaggrin, beta-fibrinogen, vimentin, and collagen type II. cit-me 136-142 vimentin Homo sapiens 228-236 27818355-7 2017 These findings suggest that glucose/fructose is transported into the cytoplasm of vimentin- or GFAP-positive astrocytic and CD68- or HLA-DR-positive microglial cells located around the lateral ventricle. Glucose 28-35 vimentin Homo sapiens 82-90 27818355-7 2017 These findings suggest that glucose/fructose is transported into the cytoplasm of vimentin- or GFAP-positive astrocytic and CD68- or HLA-DR-positive microglial cells located around the lateral ventricle. Fructose 36-44 vimentin Homo sapiens 82-90 27914516-0 2016 Leukotriene B4 induces EMT and vimentin expression in PANC-1 pancreatic cancer cells: Involvement of BLT2 via ERK2 activation. Leukotriene B4 0-14 vimentin Homo sapiens 31-39 28214837-7 2017 After 8 weeks of oral GS administration, a significantly increased expression was observed at the mRNA level for vimentin, fibromodulin, biglycan, xylosyl transferase, hyaluronan synthase, collagen types I and III, bone morphogenic protein-1, and decorin (all p <= 0.05). Glucosamine 22-24 vimentin Homo sapiens 113-121 27753543-5 2016 Moreover, silibinin treatment significantly inhibited the upregulation of the immune checkpoint regulator PD-L1 and also EMT regulators (e.g., SLUG, VIM, CD44) in crizotinib-refractory cells. Silybin 10-19 vimentin Homo sapiens 149-152 27753543-5 2016 Moreover, silibinin treatment significantly inhibited the upregulation of the immune checkpoint regulator PD-L1 and also EMT regulators (e.g., SLUG, VIM, CD44) in crizotinib-refractory cells. Crizotinib 163-173 vimentin Homo sapiens 149-152 27966519-9 2016 The EMT-related protein levels of N-Cadherin, Vimentin, Snail1, Slug, Twist1, and ZEB1 were significantly decreased by CA4, while E-cadherin had no significant difference compared with the control group. fosbretabulin 119-122 vimentin Homo sapiens 46-54 27942003-6 2016 Disruption of vimentin intermediate filaments by withaferin A reduced E to 0.92 kPa. withaferin A 49-61 vimentin Homo sapiens 14-22 26741501-9 2016 As a result, oroxylin A up-regulated E-cadherin expression and down-regulated vimentin, MMP-9, and CD44v6 expression, which could lead to the inhibition of tumor migration and invasion. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 13-23 vimentin Homo sapiens 78-86 27779676-4 2016 CoCl2 also induced an increase in the expression of hypoxia-inducible factor 1alpha (HIF1alpha) and various mesenchymal-specific markers, including vimentin and snail family transcriptional repressor 1 (Snail1), and a decrease in the expression of E-cadherin, thus suggesting that CoCl2 induced EMT in HT29 cells. cobaltous chloride 0-5 vimentin Homo sapiens 148-156 28105223-0 2016 miRNA-129-5p suppresses cell proliferation and invasion in lung cancer by targeting microspherule protein 1, E-cadherin and vimentin. mirna-129-5p 0-12 vimentin Homo sapiens 124-132 27668317-3 2016 Expression changes of E-cadherin and vimentin with PJ34 and U0126 treatment was examined using Western blot and quantitative PCR. U 0126 60-65 vimentin Homo sapiens 37-45 27668317-6 2016 PJ34 and U0126 suppressed the expression of vimentin and enhanced the expression of E-cadherin. U 0126 9-14 vimentin Homo sapiens 44-52 27914516-9 2016 LTB4-induced vimentin expression was suppressed by LY255283 (BLT2 antagonist). LY 255283 51-59 vimentin Homo sapiens 13-21 27914516-12 2016 The MEK inhibitor, PD98059 suppressed Comp A-induced vimentin expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19-26 vimentin Homo sapiens 53-61 27694444-0 2016 Structural Dynamics of the Vimentin Coiled-coil Contact Regions Involved in Filament Assembly as Revealed by Hydrogen-Deuterium Exchange. Hydrogen 109-117 vimentin Homo sapiens 27-35 27694444-0 2016 Structural Dynamics of the Vimentin Coiled-coil Contact Regions Involved in Filament Assembly as Revealed by Hydrogen-Deuterium Exchange. Deuterium 118-127 vimentin Homo sapiens 27-35 29615595-7 2016 Thymidine analog labeling and Ki67 staining of 12-week-old hearts revealed 3- and 5-fold increases of proliferation rate for vimentin+ non-cardiomyocytes in Asxl2-/- over age- and sex-matched wildtype controls, respectively. Thymidine 0-9 vimentin Homo sapiens 125-133 27751877-10 2016 Histamine exposure evoked a concentration-dependent reduction in both ZO-1 and P-cadherin and a parallel induction of vimentin mRNA expression with a maximum effect after 6h, and protein expression with a maximum effect after 8h. Histamine 0-9 vimentin Homo sapiens 118-126 27600294-5 2016 3-hydroxyflavone also affected the epithelial-mesenchymal transition (EMT) by down-regulating expressions of Vimentin and alpha-catenin with activation of the transcription factor Slug. 3-hydroxyflavone 0-16 vimentin Homo sapiens 109-117 27634300-6 2016 The results of the study found that melatonin inhibited LPS-induced morphological changes, decreased the expression of LPS-induced markers of EMT, including vimentin and alpha-smooth muscle actin, and increased the expression of E-cadherin. Melatonin 36-45 vimentin Homo sapiens 157-165 27704357-12 2016 We also identified that glioblastoma patients with low vimentin expression had a better response to temozolomide therapy. Temozolomide 100-112 vimentin Homo sapiens 55-63 27765919-5 2016 Cells treated with ZOL plus gamma-irradiation showed impaired cell migration and invasion and reduced expression of epithelial-mesenchymal transition markers (vimentin, MMP9, and Slug). Zoledronic Acid 19-22 vimentin Homo sapiens 159-167 28090191-5 2016 Furthermore, ursolic acid treatment blocked epithelial and mesenchymal transition (EMT) molecules by activating E-cadherin as an epithelial marker and attenuating Vimentin, and Twist as mesenchymal molecules. ursolic acid 13-25 vimentin Homo sapiens 163-171 27551760-0 2016 The inhibition of macrophage foam cell formation by tetrahydroxystilbene glucoside is driven by suppressing vimentin cytoskeleton. 2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside 52-82 vimentin Homo sapiens 108-116 27551760-10 2016 PMA and oxLDL increased the co-localization of vimentin with ICAM-1, which was attenuated by pretreatment with TSG. 2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside 111-114 vimentin Homo sapiens 47-55 27633040-5 2016 Furthermore, reverse transcription polymerase chain reaction (RT-PCR), western blotting and immunofluorescence results demonstrated TMP upregulation of the expression of NKG2D ligands (NKG2DLs) MHC class I chain-related molecules A and B (MICA/B) and epithelial cell expression marker of E-cadherin, and downregulation of mesenchymal cell expression markers of vimentin and fibronectin. tmp 132-135 vimentin Homo sapiens 361-369 27521227-6 2016 A significant reduction in cell migration and vimentin expression levels was observed in HRTEC primary cultures exposed to Stx2, demonstrating that the holotoxin affected HRTEC dedifferentiation. stichoposide 152-161 vimentin Homo sapiens 46-54 27423629-6 2016 Our data also showed that curcumin inhibits oxidative stress-induced cytoskeleton disarrangement, and impedes the activation of astrocytes by inhibiting upregulation of GFAP, vimentin and Prdx6. Curcumin 26-34 vimentin Homo sapiens 175-183 27495232-6 2016 It was observed that quercetin prevented TGF-beta-induced expression of vimentin and N-cadherin and increased the expression of E-cadherin in PC-3 cells, thus preventing TGF-beta-induced EMT. Quercetin 21-30 vimentin Homo sapiens 72-80 27755958-7 2016 Then the effects of HMGA2 siRNA and DOX co delivery was assessed in A549 viability and target genes (HMGA2, Ecadherin, vimentin and MMP9) by MTT and real time PCR, respectively. Doxorubicin 36-39 vimentin Homo sapiens 119-127 27613835-3 2016 Hydrogen peroxide treatment induced EMT features such as elevation of vimentin and Snail with a corresponding reduction of E-cadherin. Hydrogen Peroxide 0-17 vimentin Homo sapiens 70-78 27603133-4 2016 Furthermore, p17 was found to occupy the Plk1-binding site within the vimentin, thereby blocking Plk1 recruitment to CDK1-induced vimentin phosphorylation at Ser 56. Serine 158-161 vimentin Homo sapiens 70-78 27603133-4 2016 Furthermore, p17 was found to occupy the Plk1-binding site within the vimentin, thereby blocking Plk1 recruitment to CDK1-induced vimentin phosphorylation at Ser 56. Serine 158-161 vimentin Homo sapiens 130-138 27603133-5 2016 Interaction of p17 to CDK1 or vimentin interferes with CDK1-catalyzed phosphorylation of vimentin at Ser 56 and subsequently vimentin phosphorylation at Ser 82 by Plk1. Serine 101-104 vimentin Homo sapiens 30-38 27704357-14 2016 Low vimentin expression may benefit from temozolomide therapy. Temozolomide 41-53 vimentin Homo sapiens 4-12 27374708-4 2016 RESULTS: The paper disks were simple to prepare, and the dried disks were stable at -20 C and at 4 C. The DCT detected 212 of 215 strains (98.6% sensitivity with 95% confidence interval [CI] 96.0-99.5%) of GNB with known class A (KPC and Sme) and class B (NDM, IMP, VIM, and SIM) carbapenemases within 60 min, but failed to detect GES-5 carbapenemase. dct 106-109 vimentin Homo sapiens 266-269 27374708-7 2016 CONCLUSIONS: The DCT is simple and can be easily performed, even in small laboratories, for the rapid detection of GNB with KPC, NDM and the majority of IMP, VIM, and SIM carbapenemases. dct 17-20 vimentin Homo sapiens 158-161 27373681-3 2016 Here, PMA was shown to induce lamellipodia formation and reorganization of the adhesion sites as well as actin and vimentin filaments independently of integrin preactivation. Tetradecanoylphorbol Acetate 6-9 vimentin Homo sapiens 115-123 27500741-7 2016 Furthermore, CIMO suppressed BC cell migration and invasion with concordant regulation of genes involved in epithelial to mesechymal transition (CDH1, CDH2, OCLN and VIM). cimo 13-17 vimentin Homo sapiens 166-169 27571778-4 2016 In addition, PD168368 reduced epithelial-mesenchymal transition (EMT) of breast cancer cells by E-cadherin upregulation and vimentin downregulation. PD 168368 13-21 vimentin Homo sapiens 124-132 27643646-8 2016 Metformin reduced EMT in the cell lines and regulated the expression of the EMT-related epithelial markers, E-cadherin and Pan-keratin; the mesenchymal markers, N-cadherin, fibronectin, and vimentin; and the EMT drivers, Twist-1, snail-1, and ZEB-1. Metformin 0-9 vimentin Homo sapiens 190-198 27603133-5 2016 Interaction of p17 to CDK1 or vimentin interferes with CDK1-catalyzed phosphorylation of vimentin at Ser 56 and subsequently vimentin phosphorylation at Ser 82 by Plk1. Serine 101-104 vimentin Homo sapiens 89-97 27603133-5 2016 Interaction of p17 to CDK1 or vimentin interferes with CDK1-catalyzed phosphorylation of vimentin at Ser 56 and subsequently vimentin phosphorylation at Ser 82 by Plk1. Serine 101-104 vimentin Homo sapiens 89-97 27603133-5 2016 Interaction of p17 to CDK1 or vimentin interferes with CDK1-catalyzed phosphorylation of vimentin at Ser 56 and subsequently vimentin phosphorylation at Ser 82 by Plk1. Serine 153-156 vimentin Homo sapiens 30-38 27603133-5 2016 Interaction of p17 to CDK1 or vimentin interferes with CDK1-catalyzed phosphorylation of vimentin at Ser 56 and subsequently vimentin phosphorylation at Ser 82 by Plk1. Serine 153-156 vimentin Homo sapiens 89-97 27603133-5 2016 Interaction of p17 to CDK1 or vimentin interferes with CDK1-catalyzed phosphorylation of vimentin at Ser 56 and subsequently vimentin phosphorylation at Ser 82 by Plk1. Serine 153-156 vimentin Homo sapiens 89-97 27603133-6 2016 Furthermore, we have identified upstream signaling pathways and cellular factor(s) targeted by p17 and found that p17 regulates inhibitory phosphorylation of CDK1 and blocks vimentin phosphorylation at Ser 56 and Ser 82. Serine 202-205 vimentin Homo sapiens 174-182 27603133-6 2016 Furthermore, we have identified upstream signaling pathways and cellular factor(s) targeted by p17 and found that p17 regulates inhibitory phosphorylation of CDK1 and blocks vimentin phosphorylation at Ser 56 and Ser 82. Serine 213-216 vimentin Homo sapiens 174-182 27350211-7 2016 ChNP/siRNA/DOX/CMD was more effective to induce tumour cell death and also could significantly reduce the expressions of HMGA2, vimentin as well as MMP-9 and increase E-cadherin expression. Doxorubicin 11-14 vimentin Homo sapiens 128-136 27335427-8 2016 Chemical disruption of vimentin filament organization increased progesterone production. Progesterone 64-76 vimentin Homo sapiens 23-31 27329104-3 2016 We found an increased infiltration of TALs, which was associated with downregulation of E-cadherin and over-expression of vimentin in the breast carcinoma tissues of pLNs as compared to nLNs patients and normal breast tissues obtained from healthy volunteers during mammoplasty. tals 38-42 vimentin Homo sapiens 122-130 27515856-3 2016 Immunohistochemically, PHE is usually positive for vimentin, cytokeratin, CD31 and ERG. Phenylalanine 23-26 vimentin Homo sapiens 51-59 27367032-5 2016 By using PCR arrays and FACS analysis, we found that the CPS-treated BC cells displayed typical mesenchymal features of the epithelial mesenchymal transition (EMT) as elongated shape and over-expression of vimentin, alpha5 and beta1 integrin subunits, integrin-like kinase and the anti-apoptotic Bcl-2 proteins. Capsaicin 57-60 vimentin Homo sapiens 206-214 27106722-9 2016 RESULTS: We found that high glucose stimulated MDA-MB-231 cell proliferation, migration and invasion, together with an increased expression of mesenchymal markers (i.e., vimentin and fibronectin). Glucose 28-35 vimentin Homo sapiens 170-178 27480627-3 2016 Our present study revealed that nanomolar BPA can significantly increase the in vitro migration and invasion of HA cells via induction of epithelial-mesenchymal transition (EMT), which was evidenced by the upregulation of vimentin and downregulation of E-cadherin. bisphenol A 42-45 vimentin Homo sapiens 222-230 27480627-5 2016 Silencing of Snail by small interfering RNAs attenuated BPA-induced downregulation of cadherin and upregulation of vimentin, suggesting that Snail is essential for BPA-induced EMT. bisphenol A 56-59 vimentin Homo sapiens 115-123 27480627-5 2016 Silencing of Snail by small interfering RNAs attenuated BPA-induced downregulation of cadherin and upregulation of vimentin, suggesting that Snail is essential for BPA-induced EMT. bisphenol A 164-167 vimentin Homo sapiens 115-123 27687652-3 2016 Western blotting and quantitative RT-PCR were used to examine the protein and mRNA expressions of EMT markers E-cadherin and vimentin and endoplasmic reticulum stress marker glucose-regulated protein (GRP) 78 in cells treated with SB203580 (an inhibitor of the p38 MAPK signaling pathway) prior to AOPP exposure. SB 203580 231-239 vimentin Homo sapiens 125-133 27687652-6 2016 AOPP-induced decrease in E-cadherin expression and overexpression of vimentin and GRP78 were partly inhibited by pretreatment of the cells with SB203580. SB 203580 144-152 vimentin Homo sapiens 69-77 27335427-9 2016 Taken together, these results suggest that hCG-stimulated dephosphorylation of MAP2D at Thr256 and Thr259, phosphorylation of vimentin at Ser38 and Ser72, and the resulting enhanced binding of MAP2D to vimentin might contribute to the progesterone synthetic response required for ovulation. DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-GLYCINE 43-46 vimentin Homo sapiens 126-134 27335427-9 2016 Taken together, these results suggest that hCG-stimulated dephosphorylation of MAP2D at Thr256 and Thr259, phosphorylation of vimentin at Ser38 and Ser72, and the resulting enhanced binding of MAP2D to vimentin might contribute to the progesterone synthetic response required for ovulation. DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-GLYCINE 43-46 vimentin Homo sapiens 202-210 27335427-9 2016 Taken together, these results suggest that hCG-stimulated dephosphorylation of MAP2D at Thr256 and Thr259, phosphorylation of vimentin at Ser38 and Ser72, and the resulting enhanced binding of MAP2D to vimentin might contribute to the progesterone synthetic response required for ovulation. Progesterone 235-247 vimentin Homo sapiens 126-134 27357025-6 2016 The PKCalpha inhibitor Go6976 was used to treat MDA-MB-231 and Hs578T TNBC cells, which resulted in decreased expression of AXL and epithelia-mesenchymal transition-related gene vimentin, and decreased cell proliferation. Go 6976 23-29 vimentin Homo sapiens 178-186 27563634-2 2016 The aim of this study is to evaluate the expression of IMP and VIM in Pseudomonas aeruginosa strains (carbapenem resistant and producer MBL enzyme) in patients with secondary immunodeficiency. Carbapenems 102-112 vimentin Homo sapiens 63-66 27446441-6 2016 The protein expression of Janus kinase 2, STAT3, phosphorylated-STAT3, Snail, N-cadherin and vimentin decreased in sinomenine-treated cells, while E-cadherin protein expression increased. sinomenine 115-125 vimentin Homo sapiens 93-101 26883251-7 2016 Under different concentrations of 5-FU and paclitaxel in MDA-MB231 cell, E-cadherin mRNA and protein expressions increased gradually with the increase of concentrations, and Vimentin and N-cadherin mRNA and protein expressions decreased gradually with the decrease of concentrations (all P < 0.05). Fluorouracil 34-38 vimentin Homo sapiens 174-182 26883251-7 2016 Under different concentrations of 5-FU and paclitaxel in MDA-MB231 cell, E-cadherin mRNA and protein expressions increased gradually with the increase of concentrations, and Vimentin and N-cadherin mRNA and protein expressions decreased gradually with the decrease of concentrations (all P < 0.05). Paclitaxel 43-53 vimentin Homo sapiens 174-182 27322682-4 2016 Overexpression of vimentin in A2780-DR cells markedly increased their sensitivity to cisplatin, whereas knockdown of vimentin in A2780, HO-8910-PM and HO-8910 cells increased the resistance to cisplatin, demonstrating that vimentin silencing enhanced cisplatin resistance in ovarian cancer cells. Cisplatin 85-94 vimentin Homo sapiens 18-26 27322682-4 2016 Overexpression of vimentin in A2780-DR cells markedly increased their sensitivity to cisplatin, whereas knockdown of vimentin in A2780, HO-8910-PM and HO-8910 cells increased the resistance to cisplatin, demonstrating that vimentin silencing enhanced cisplatin resistance in ovarian cancer cells. Cisplatin 193-202 vimentin Homo sapiens 117-125 27322682-4 2016 Overexpression of vimentin in A2780-DR cells markedly increased their sensitivity to cisplatin, whereas knockdown of vimentin in A2780, HO-8910-PM and HO-8910 cells increased the resistance to cisplatin, demonstrating that vimentin silencing enhanced cisplatin resistance in ovarian cancer cells. Cisplatin 193-202 vimentin Homo sapiens 117-125 27322682-4 2016 Overexpression of vimentin in A2780-DR cells markedly increased their sensitivity to cisplatin, whereas knockdown of vimentin in A2780, HO-8910-PM and HO-8910 cells increased the resistance to cisplatin, demonstrating that vimentin silencing enhanced cisplatin resistance in ovarian cancer cells. Cisplatin 193-202 vimentin Homo sapiens 117-125 27322682-4 2016 Overexpression of vimentin in A2780-DR cells markedly increased their sensitivity to cisplatin, whereas knockdown of vimentin in A2780, HO-8910-PM and HO-8910 cells increased the resistance to cisplatin, demonstrating that vimentin silencing enhanced cisplatin resistance in ovarian cancer cells. Cisplatin 193-202 vimentin Homo sapiens 117-125 27322682-5 2016 Quantitative proteomic analysis identified 95 differentially expressed proteins between the vimentin silenced A2780 cells (A2780-VIM-KN) and the control cells, in which downregulation of endocytic proteins and the upregulation of exocytotic proteins CHMP2B and PDZK1 were proposed to contribute the decreased cisplatin accumulation in vimentin knockdown cells. Cisplatin 309-318 vimentin Homo sapiens 92-100 27322682-7 2016 Our results also revealed that vimentin knockdown increased the 14-3-3 mediated retention of Cdc25C in the cytoplasm, leading to inactivation of Cdk1 and the prolonged G2 phase arrest that allowed the longer period of time for cells to repair cisplatin-damaged DNA. Cisplatin 243-252 vimentin Homo sapiens 31-39 27322682-8 2016 Taken together, we demonstrated that vimentin silencing enhanced cells" resistance to cisplatin via prolonged G2 arrest and increased exocytosis, suggesting that vimentin is a potential target for treatment of drug resistant ovarian cancer. Cisplatin 86-95 vimentin Homo sapiens 37-45 27322682-8 2016 Taken together, we demonstrated that vimentin silencing enhanced cells" resistance to cisplatin via prolonged G2 arrest and increased exocytosis, suggesting that vimentin is a potential target for treatment of drug resistant ovarian cancer. Cisplatin 86-95 vimentin Homo sapiens 162-170 28591947-9 2016 Furthermore Beas-2b cells induced by CS that underwent EMT showed increased E-cadherin and decreased vimentin and alpha-SMA after treatment with PF-5274857 for 4 d. Importantly, the elevated migration capacity level was also decreased. Cesium 37-39 vimentin Homo sapiens 101-109 27237097-9 2016 Inositol slowed-down vimentin expression in cells placed behind the wound-healing edge and stabilized cortical F-actin. Inositol 0-8 vimentin Homo sapiens 21-29 27237409-7 2016 Gliosis was attenuated in MNU10 treated explants, with expression of vimentin, glial fibrillary protein (GFAP), glutamine synthetase (GS), and bFGF comparable to in vivo controls. mnu10 26-31 vimentin Homo sapiens 69-77 27220595-6 2016 With CoCl2, the ESCC cells showed increased migration and invasion abilities, accompanied with upregulation of HIF-1alpha, STAT3, and vimentin, and downregulation of E-cadherin. cobaltous chloride 5-10 vimentin Homo sapiens 134-142 27569939-6 2016 Patients with IFTA on biopsy had higher mean concentration of anti-vimentin antibodies when compared to patients without IFTA (32.2 mug/mL [3.97-269.12 mug/mL] vs 14.57 mug/mL [4.71-87.81 mug/mL]). ifta 14-18 vimentin Homo sapiens 67-75 27569939-7 2016 The risk of developing IFTA with a concentration of anti-vimentin antibody >15 mug/mL before transplantation was 1.96 (95% CI = 1.38-2.79, P = .011). ifta 23-27 vimentin Homo sapiens 57-65 27569939-8 2016 Patients with elevated anti-vimentin antibody concentrations (>15 mug/mL) at the time of transplantation also had a higher risk of developing IFTA (81.4% vs 41.2%; P < .05). ifta 145-149 vimentin Homo sapiens 28-36 26733180-6 2016 Western blotting analysis reveals that gigantol greatly decreases epithelial to mesenchymal transition (EMT) markers including N-cadherin, vimentin, and Slug leading to a significant suppression of protein kinase B (AKT), extracellular signal-regulated kinase (ERK), and caveolin-1 (cav-1) survival pathways during the detached condition. gigantol 39-47 vimentin Homo sapiens 139-147 26810188-8 2016 In addition, niclosamide reversed the EMT phenotype of 231-CR by downregulation of snail and vimentin. Niclosamide 13-24 vimentin Homo sapiens 93-101 27157519-4 2016 We aimed to investigate the effects of DHA on gelsolin and vimentin expression, and ultimately cell migration and proliferation, in this context. Docosahexaenoic Acids 39-42 vimentin Homo sapiens 59-67 28335269-3 2016 To achieve this goal, we developed an ASGPR receptor targeted co-delivery system called gal-doxorubicin/vimentin siRNA liposome (Gal-DOX/siRNA-L). gal-dox 129-136 vimentin Homo sapiens 104-112 28335269-4 2016 The Gal-DOX/siRNA-L was created via electrostatic interaction of galactose linked-cationic liposomal doxorubicin (Gal-DOX-L) on vimentin siRNA. gal-dox 4-11 vimentin Homo sapiens 128-136 28335269-4 2016 The Gal-DOX/siRNA-L was created via electrostatic interaction of galactose linked-cationic liposomal doxorubicin (Gal-DOX-L) on vimentin siRNA. Galactose 65-74 vimentin Homo sapiens 128-136 28335269-4 2016 The Gal-DOX/siRNA-L was created via electrostatic interaction of galactose linked-cationic liposomal doxorubicin (Gal-DOX-L) on vimentin siRNA. Doxorubicin 101-112 vimentin Homo sapiens 128-136 28335269-4 2016 The Gal-DOX/siRNA-L was created via electrostatic interaction of galactose linked-cationic liposomal doxorubicin (Gal-DOX-L) on vimentin siRNA. gal-dox-l 114-123 vimentin Homo sapiens 128-136 28335269-5 2016 Previous studies have shown that Gal-DOX/siRNA-L inhibited tumor growth by combined effect of DOX and vimentin siRNA than single delivery of either DOX or vimentin siRNA. gal-dox 33-40 vimentin Homo sapiens 102-110 28335269-5 2016 Previous studies have shown that Gal-DOX/siRNA-L inhibited tumor growth by combined effect of DOX and vimentin siRNA than single delivery of either DOX or vimentin siRNA. Doxorubicin 37-40 vimentin Homo sapiens 102-110 27126361-7 2016 Moreover, suppressing ARK5 by siRNA restored E-cadherin and vimentin expression induced by doxorubicin treatment or hypoxia culture. Doxorubicin 91-102 vimentin Homo sapiens 60-68 27346397-7 2016 In the Ishikawa cells, mifepristone suppressed the transcriptional level of H19 through enhancing its promoter methylation, which resulted in inhibited expressions of HMGA2 and vimentin and increased expression of E-cadherin in a time- and concentration-dependent manner. Mifepristone 23-35 vimentin Homo sapiens 177-185 27346397-8 2016 CONCLUSION: Mifepristone inhibits the migration of endometrial carcinoma cells partially through methylation-induced of transcriptional inhibition of H19, which results in the down-regulation of HMGA2 and vimentin and upregulation of E-cadherin. Mifepristone 12-24 vimentin Homo sapiens 205-213 27398136-6 2016 Treatment of cells with doxorubicin or hypoxia was shown to trigger EMT as evidenced by decreased E-cadherin and increased Vimentin. Doxorubicin 24-35 vimentin Homo sapiens 123-131 27157519-9 2016 DHA and 8 Br-cAMP altered gelsolin and vimentin expression but no clear pattern of change was observed. Docosahexaenoic Acids 0-3 vimentin Homo sapiens 39-47 27157519-9 2016 DHA and 8 Br-cAMP altered gelsolin and vimentin expression but no clear pattern of change was observed. 8-Bromo Cyclic Adenosine Monophosphate 10-17 vimentin Homo sapiens 39-47 27157519-11 2016 SIGNIFICANCE: Collectively, our data indicate that DHA inhibits cancer cell migration and further suggests that vimentin and gelsolin may play secondary roles in cancer cell migration and proliferation, but are not the primary regulators. Docosahexaenoic Acids 51-54 vimentin Homo sapiens 112-120 27072512-5 2016 Butyrate/HDACi-resistant CRC cells differ from their butyrate/HDACi-sensitive counterparts in the expression of many genes, including the gene encoding vimentin (VIM) that is usually expressed in normal mesenchymal cells and is involved in cancer metastasis. Butyrates 53-61 vimentin Homo sapiens 152-160 27082017-7 2016 Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB. Curcumin 23-31 vimentin Homo sapiens 179-187 27072512-5 2016 Butyrate/HDACi-resistant CRC cells differ from their butyrate/HDACi-sensitive counterparts in the expression of many genes, including the gene encoding vimentin (VIM) that is usually expressed in normal mesenchymal cells and is involved in cancer metastasis. Butyrates 53-61 vimentin Homo sapiens 162-165 27072512-6 2016 Interestingly, vimentin is overexpressed in butyrate/HDACi-resistant CRC cells although Wnt signalling is suppressed in such cells and that VIM is a Wnt activity-targeted gene. Butyrates 44-52 vimentin Homo sapiens 15-23 27072512-9 2016 Based upon these observations, we propose that the differential expression of vimentin contributes to the phenotypic differences between butyrate-resistant and butyrate-sensitive CRC cells, as well as to the differences between early-stage and metastatic colorectal neoplastic cells. Butyrates 137-145 vimentin Homo sapiens 78-86 27072512-9 2016 Based upon these observations, we propose that the differential expression of vimentin contributes to the phenotypic differences between butyrate-resistant and butyrate-sensitive CRC cells, as well as to the differences between early-stage and metastatic colorectal neoplastic cells. Butyrates 160-168 vimentin Homo sapiens 78-86 27059791-4 2016 RESULTS: Poly I:C induced myofibroblastic-like morphologic changes, degradation of IkappaB-alpha consistent with TLR3-NFkappaB activation, a 15-fold increase in the expression of Vimentin, a 9-fold increase in Collagen-1a, a 4.6-fold increase in Snail at 24h (p<0.05), and an 8.2-fold increase in Prom1 at 72h (p<0.0001) by qPCR. poly I:C 9-17 vimentin Homo sapiens 179-187 27059791-7 2016 Co-treatment with either nafamostat or SB431542 blocked the morphologic change and abrogated the increased expression of Cd133, Collagen, Vimentin, and Snail1. nafamostat 25-35 vimentin Homo sapiens 138-146 27059791-7 2016 Co-treatment with either nafamostat or SB431542 blocked the morphologic change and abrogated the increased expression of Cd133, Collagen, Vimentin, and Snail1. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 39-47 vimentin Homo sapiens 138-146 27320884-5 2016 RESULTS: DADS inhibited the invasion and migration of MCF-7 cells in a dose-dependent manner, down-regulated the protein expression of Vimentin and MMP-9 and up-regulated E-cadherin expression in the cells. diallyl disulfide 9-13 vimentin Homo sapiens 135-143 30911611-3 2016 MCs express a wide range of phenotypic markers, including vimentin and cytokeratins. mcs 0-3 vimentin Homo sapiens 58-66 25968914-6 2016 Our data indicated that quercetin can induce the expression of E-cadherin and also downregulate vimentin levels in TNBC. Quercetin 24-33 vimentin Homo sapiens 96-104 27058759-10 2016 While inhibitor of PI3K/Akt, LY294002, abolishes visfatin induced up regulation of Snail, Vimentin (Vim), beta-catenin, and phosphorylated GSK-3beta. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 vimentin Homo sapiens 90-98 27058759-10 2016 While inhibitor of PI3K/Akt, LY294002, abolishes visfatin induced up regulation of Snail, Vimentin (Vim), beta-catenin, and phosphorylated GSK-3beta. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 vimentin Homo sapiens 90-93 27868408-10 2016 In addition, GSK126 up-regulated E-cadherin mRNA expression and down-regulated N-cadherin and Vimentin mRNA expression, whereas had no significant effect on Snail, Fibronectin and VEGF-A mRNA expression. GSK-2816126 13-19 vimentin Homo sapiens 94-102 26983576-6 2016 Additionally, tetrandrine reverses EMT by increasing the expression of E-cadherin and reducing the N-cadherin, vimentin and Slug expression in a dose-dependent manner. tetrandrine 14-25 vimentin Homo sapiens 111-119 27123120-5 2016 It was demonstrated that simvastatin inhibited the EMT as assessed by reduced expression of N-cadherin and vimentin, and increased E-cadherin in TGF-beta1 treated DU145 PCa cells. Simvastatin 25-36 vimentin Homo sapiens 107-115 26985708-9 2016 In addition, the progression of ETM was inhibited due to the overexpression of E-cadherin as well as the downregulation of vimentin. etm 32-35 vimentin Homo sapiens 123-131 30091550-6 2016 Compared with Arisaematis Rhizoma polysaccharide group and cisplatin group, there were higher in the early,late apoptosis rate and E-cadherin mRNA levels, lower the mRNA levels of Vimentin, N-cadherin, FN and p-Akt / Akt in combined group( P <0. Cisplatin 59-68 vimentin Homo sapiens 180-188 26935987-7 2016 A set of experiments showed that sulforaphase inhibited hepatocellular carcinoma cell migration and invasion, inhibited the formation of fibroblast like mesenchymal cells and the expression of Vimentin, but increased the expression of E-cadherin, suggesting sulforaphane suppresses epithelial-mesenchymal transition (EMT) process. sulforaphase 33-45 vimentin Homo sapiens 193-201 26935987-8 2016 Cotreatment with N-acetyl-L-cysteine inhibited sulforaphane-inhibited invasion and upregulation of E-cadherin and almost completely abolished the sulforaphane-induced expression of Vimentin. Acetylcysteine 17-36 vimentin Homo sapiens 181-189 26935987-8 2016 Cotreatment with N-acetyl-L-cysteine inhibited sulforaphane-inhibited invasion and upregulation of E-cadherin and almost completely abolished the sulforaphane-induced expression of Vimentin. sulforaphane 47-59 vimentin Homo sapiens 181-189 26935987-8 2016 Cotreatment with N-acetyl-L-cysteine inhibited sulforaphane-inhibited invasion and upregulation of E-cadherin and almost completely abolished the sulforaphane-induced expression of Vimentin. sulforaphane 146-158 vimentin Homo sapiens 181-189 26971374-3 2016 By using primary epithelial cells isolated from human fetal palatal shelves (hFPECs), we show that TCDD increased cell proliferation and EMT, as demonstrated by increased the epithelial markers (E-cadherin and cytokeratin14) and enhanced the mesenchymal markers (vimentin and fibronectin), but had no effect on cell migration and apoptosis. Polychlorinated Dibenzodioxins 99-103 vimentin Homo sapiens 263-271 26971374-7 2016 Knockdown of AhR by siRNA remarkably weakened TCDD-induced binding of AhR to the XRE promoter of slug, thereby suppressed TCDD-induced vimentin. Polychlorinated Dibenzodioxins 46-50 vimentin Homo sapiens 135-143 26971374-7 2016 Knockdown of AhR by siRNA remarkably weakened TCDD-induced binding of AhR to the XRE promoter of slug, thereby suppressed TCDD-induced vimentin. Polychlorinated Dibenzodioxins 122-126 vimentin Homo sapiens 135-143 27136519-8 2016 In addition to elevation of E-cadherin, downregulations of ZEB1, N-cadherin, and vimentin were found in AESN-treated MCF-7 breast cancer cells. aesn 104-108 vimentin Homo sapiens 81-89 27102372-5 2016 RESULTS: We create poly(lactic-co-glycolic) acid NPs modified with MPG, polyethylene glycol (PEG), MPG/PEG, and Vimentin (VIM), and evaluate their cellular uptake in 2D (monolayer) cell culture of human cervical carcinoma (HeLa). Polylactic Acid-Polyglycolic Acid Copolymer 19-48 vimentin Homo sapiens 112-120 27118643-3 2016 METHODS: Real-time PCR and Western blot were used to detect the expression changes of EMT-related markers, E-cadherin and Vimentin, in A549 lung cancer cells treated with nicotine; The transposition of beta-catenin protein expression was determined by immunofluorescence; Scratch test and Transwell invasion assay were used to detect the effects of nicotine on lung cancer cell migration and invasion. Nicotine 171-179 vimentin Homo sapiens 122-130 27102372-5 2016 RESULTS: We create poly(lactic-co-glycolic) acid NPs modified with MPG, polyethylene glycol (PEG), MPG/PEG, and Vimentin (VIM), and evaluate their cellular uptake in 2D (monolayer) cell culture of human cervical carcinoma (HeLa). Polylactic Acid-Polyglycolic Acid Copolymer 19-48 vimentin Homo sapiens 122-125 26679052-8 2016 Moreover, antrocin increased epithelial-to-mesenchymal transition-related gene E-cadherin and decreased vimentin expression. antrocin 10-18 vimentin Homo sapiens 104-112 26846904-8 2016 In addition, in vivo studies revealed that transcutaneous CO2 increased E-cadherin expression with the decreased expression of HIF-1alpha, Snail, Slug, N-cadherin, and Vimentin in tumor treatment. Carbon Dioxide 58-61 vimentin Homo sapiens 168-176 26958938-6 2016 Furthermore, the epithelial-to-mesenchymal transition (EMT) was inhibited in bufalin-treated tumors, as reflected the upregulation of E-cadherin, and downregulation of N-cadherin, vimentin, Snail. bufalin 77-84 vimentin Homo sapiens 180-188 26934679-3 2016 The objectives of this study were to evaluate the formation of mammospheres from the canine and human breast cancer cell lines, CMT-U229 and MCF-7, and the effects of melatonin treatment on the modulation of stem cell and EMT molecular markers: OCT4, E-cadherin, N-cadherin and vimentin, as well as on cell viability and invasiveness of the cells from mammospheres. Melatonin 167-176 vimentin Homo sapiens 278-286 27073542-10 2016 Furthermore, lapatinib induced the downregulation of vimentin and upregulation of E-cadherin in HNSCC11A cells in a time-dependent manner. Lapatinib 13-22 vimentin Homo sapiens 53-61 26443721-7 2016 Our data also suggested that the enhanced cell migration involves the epithelium to mesenchymal transition (EMT) process, since a 12 h stimulation of SKOV-3 cells with 100 muM UTP showed an increase in vimentin and SNAIL protein levels (459.8 +- 132.4% over basal for SNAIL). Uridine Triphosphate 176-179 vimentin Homo sapiens 202-210 26643609-5 2016 Lapatinib-resistant SKBR3 and BT474 cells exhibited up-regulation of the phenotypic epithelial-mesenchymal transition markers Snail, vimentin and alpha-smooth muscle actin, accompanied by activation of nuclear factor-kB and Src and a concomitant increase in stem cell marker expression (CD44(high)/CD24(low)), compared to naive lapatinib-sensitive SKBR3 and BT474 cells, respectively. Lapatinib 0-9 vimentin Homo sapiens 133-141 26932781-0 2016 Pharmacoproteomic analysis reveals that metapristone (RU486 metabolite) intervenes E-cadherin and vimentin to realize cancer metastasis chemoprevention. metapristone 40-52 vimentin Homo sapiens 98-106 26932781-0 2016 Pharmacoproteomic analysis reveals that metapristone (RU486 metabolite) intervenes E-cadherin and vimentin to realize cancer metastasis chemoprevention. Mifepristone 54-59 vimentin Homo sapiens 98-106 26783187-7 2016 E-cadherin expression was lower, and vimentin and ZEB1 expression were higher in 5 nintedanib-resistant cell lines. nintedanib 83-93 vimentin Homo sapiens 37-45 26871290-8 2016 Similar results were observed for DADS-induced changes in the expression of vimentin, CD34, Ki-67, and E-cadherin in xenografted tumors. diallyl disulfide 34-38 vimentin Homo sapiens 76-84 26808085-3 2016 In this study, it was demonstrated that 8-MOP inhibited HCC HepG2 cells and SMMC-7721 cells migratory and invasive potentiality, as well as modulated the expression of various EMT-associated genes such as enhancing E-cadherin and reducing N-cadherin, vimentin, alpha-SMA and MMP9 in a concentration-dependent way. Methoxsalen 40-45 vimentin Homo sapiens 251-259 26923772-11 2016 A significant reduction in OS was shown in patients with vimentin-positive CTC compared to those without vimentin-positive CTC (median 305 days vs 453 days, p = 0.0293). Osmium 27-29 vimentin Homo sapiens 57-65 26923772-11 2016 A significant reduction in OS was shown in patients with vimentin-positive CTC compared to those without vimentin-positive CTC (median 305 days vs 453 days, p = 0.0293). Osmium 27-29 vimentin Homo sapiens 105-113 26796277-10 2016 miR-138 overexpression also down-regulated vimentin expression and upregulated E-cadherin expression, suggesting that miR-138 inhibited EMT. mir-138 0-7 vimentin Homo sapiens 43-51 26796277-10 2016 miR-138 overexpression also down-regulated vimentin expression and upregulated E-cadherin expression, suggesting that miR-138 inhibited EMT. mir-138 118-125 vimentin Homo sapiens 43-51 26902198-4 2016 Additionally, ATRA effectively upregulated the protein level of NIS, and reversed EMT phenotype in alcohol treated cells, with absence in epithelial expression of E-cadherin and cytokeratin 18, as well as abnormal expression of Vimentin, urinary plasminogen activator (uPA), uPAR and Fibronectin.Compared with alcohol-treated group, both in vitro proliferation and invasion potential of ATRA treated cells markedly decreased (all P<0.05), and iodine uptake in vitro increased about 3.5-folds (P=0.007). Tretinoin 14-18 vimentin Homo sapiens 228-236 26902198-4 2016 Additionally, ATRA effectively upregulated the protein level of NIS, and reversed EMT phenotype in alcohol treated cells, with absence in epithelial expression of E-cadherin and cytokeratin 18, as well as abnormal expression of Vimentin, urinary plasminogen activator (uPA), uPAR and Fibronectin.Compared with alcohol-treated group, both in vitro proliferation and invasion potential of ATRA treated cells markedly decreased (all P<0.05), and iodine uptake in vitro increased about 3.5-folds (P=0.007). Alcohols 99-106 vimentin Homo sapiens 228-236 26682631-7 2016 DS (5.76 muM)-treated MDA-MB-231 cells exhibited the morphological characteristic of epithelial-like cells; mRNA expression of DNMT3A, TET2, TET3, ZFPM2 and E-cad were increased while TET1, VIM and MMP9 were decreased. dioscin 0-2 vimentin Homo sapiens 190-193 25620490-4 2016 Here we show that Cr(VI) induces expression of mesenchymal and stem cell markers, cell markers, such as paxillin, vimentin, alpha-SMA, nanog, and CD133 of HK-2 cells. chromium hexavalent ion 18-24 vimentin Homo sapiens 114-122 26769084-8 2016 Furthermore, the incubation of TAMs conditioned medium resulted in a fibroblast-like appearance of cancer cells (HN4, HN6 and SCC9) together with the decreased/increased expression of E-cadherin/ vimentin, which were correlated with the enhanced ability of migration and invasion. tams 31-35 vimentin Homo sapiens 196-204 26609108-7 2016 Significantly, MNK inhibitors increase E-cadherin mRNA levels and decrease vimentin mRNA levels in human PDAC organoids without affecting ZEB1 mRNA levels. pdac organoids 105-119 vimentin Homo sapiens 75-83 26893768-6 2016 Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, extracellular signal-regulated kinase and Snail. Curcumin 13-21 vimentin Homo sapiens 96-104 26548370-3 2016 3-Arylquinolines or "arylquins" induce normal cells to release Par-4 from the intermediate filament protein, vimentin and promote Par-4 secretion that targets cancer cells in a paracrine manner. arylquins 21-30 vimentin Homo sapiens 109-117 26463583-7 2016 ALA inhibited epithelial mesenchymal transition (EMT) evidently by increase of E-cadherin and decreases of activated beta-catenin, vimentin, snail, and twist in these cells. Thioctic Acid 0-3 vimentin Homo sapiens 131-139 26517522-7 2016 Quantitative real time PCR, fluorescent microscopy, and cell migration assays all confirmed that Lovastatin inhibits integrin alphavbeta3 downstream signaling including FAK activation, and beta-catenin, vimentin, ZO-1, and beta-actin. Lovastatin 97-107 vimentin Homo sapiens 203-211 27640392-1 2016 A novel trinuclear copper(II) complex [Cu3(mu-Cl)2Cl4(1-Vim)6] with monodentate 1-vinylimidazole (1-Vim) and chloro ligands has been prepared and experimentally characterized by elemental analysis, thermogravimetry (TGA, DTG, DTA), X-ray single crystal diffractometry, TOF-MS and FT-IR spectroscopies. cupric ion 19-29 vimentin Homo sapiens 56-59 27640392-1 2016 A novel trinuclear copper(II) complex [Cu3(mu-Cl)2Cl4(1-Vim)6] with monodentate 1-vinylimidazole (1-Vim) and chloro ligands has been prepared and experimentally characterized by elemental analysis, thermogravimetry (TGA, DTG, DTA), X-ray single crystal diffractometry, TOF-MS and FT-IR spectroscopies. cupric ion 19-29 vimentin Homo sapiens 100-103 27640392-1 2016 A novel trinuclear copper(II) complex [Cu3(mu-Cl)2Cl4(1-Vim)6] with monodentate 1-vinylimidazole (1-Vim) and chloro ligands has been prepared and experimentally characterized by elemental analysis, thermogravimetry (TGA, DTG, DTA), X-ray single crystal diffractometry, TOF-MS and FT-IR spectroscopies. Sodium Hypochlorite 109-115 vimentin Homo sapiens 56-59 26616052-10 2016 Moreover, vimentin-disrupted chondrocytes didn"t show much difference to control cells in responding to reagents that target actin and ROCK pathway, but showed a weaker response to histamine and isoproterenol. Histamine 181-190 vimentin Homo sapiens 10-18 26616052-10 2016 Moreover, vimentin-disrupted chondrocytes didn"t show much difference to control cells in responding to reagents that target actin and ROCK pathway, but showed a weaker response to histamine and isoproterenol. Isoproterenol 195-208 vimentin Homo sapiens 10-18 26431101-3 2016 SAHA treatment significantly down-regulates the expression of epithelial markers E-cadherin (E-Cad) while up-regulates the mesenchymal markers N-cadherin (N-Cad), vimentin (Vim) and fibronectin (FN). Vorinostat 0-4 vimentin Homo sapiens 163-171 26431101-3 2016 SAHA treatment significantly down-regulates the expression of epithelial markers E-cadherin (E-Cad) while up-regulates the mesenchymal markers N-cadherin (N-Cad), vimentin (Vim) and fibronectin (FN). Vorinostat 0-4 vimentin Homo sapiens 173-176 26431101-7 2016 Further, silence of HDAC8, while not HDAC6, alleviates the down-regulation of FOXA1 and up-regulation of N-Cad and Vim in MDA-MB-231 cells treated with SAHA. Vorinostat 152-156 vimentin Homo sapiens 115-118 26433470-9 2016 P2Y6 siRNA-mediated silencing and the P2Y6 pharmacological inhibitor MRS2578 reduced hypoxia-induced vimentin protein expression in MDA-MB-468 cells. N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea 69-76 vimentin Homo sapiens 101-109 26548370-0 2016 Par-4 secretion: stoichiometry of 3-arylquinoline binding to vimentin. 3-arylquinoline 34-49 vimentin Homo sapiens 61-69 26548370-3 2016 3-Arylquinolines or "arylquins" induce normal cells to release Par-4 from the intermediate filament protein, vimentin and promote Par-4 secretion that targets cancer cells in a paracrine manner. 3-arylquinolines 0-16 vimentin Homo sapiens 109-117 26603905-6 2016 Phenotypically, PQ induced-EMT was characterized by loss of epithelial cell markers including E-cadherin and zonula occludens (ZO-1), while up-expressions of mesenchymal cell markers including alpha-smooth muscle actin (alpha-SMA) and vimentin, concurrent with increased type I collagen (Col I). Paraquat 16-18 vimentin Homo sapiens 235-243 26206483-7 2016 RESULTS: VPA induced the increase in E-cadherin (p < 0.05), and the decrease in N-cadherin (p < 0.05) and Vimentin (p < 0.05), in PCa cells and xenografts. Valproic Acid 9-12 vimentin Homo sapiens 112-120 27279583-11 2016 However, in ovarian cells the expression of Snail, Slug, and vimentin was enhanced by the treatment of BPA, whereas E-cadherin was decreased. bisphenol A 103-106 vimentin Homo sapiens 61-69 29062470-1 2016 We establish a novel mathematical model to describe and analyze pH levels in the vicinity of poly(N-vinylcaprolactam-co-acetoacetoxyethyl methacrylate-co-N-vinylimidazole) (VCL/AAEM/VIm) microgel-functionalized polymers during biodegradation. poly(n-vinylcaprolactam-co-acetoacetoxyethyl methacrylate-co-n-vinylimidazole) 93-171 vimentin Homo sapiens 182-185 29064649-0 2016 Modelling pH-Optimized Degradation of Microgel-Functionalized Polyesters We establish a novel mathematical model to describe and analyze pH levels in the vicinity of poly(N-vinylcaprolactam-co-acetoacetoxyethyl methacrylate-co-N-vinylimidazole) (VCL/AAEM/VIm) microgel-functionalized polymers during biodegradation. poly(n-vinylcaprolactam-co-acetoacetoxyethyl methacrylate-co-n-vinylimidazole) 166-244 vimentin Homo sapiens 255-258 26384689-7 2016 In terms of EMT, treatment of the cells with moscatilin significantly suppressed mesenchymal cell markers, namely vimentin, Slug, and Snail. dendrophenol 45-55 vimentin Homo sapiens 114-122 26872755-9 2016 CONCLUSION: LTSP syndrome is a rare entity presenting with abdominal pain, bowel obstruction, ascites, ovarian masses, and SP containing specialized (vimentin+/keratin+/CD34+) SMF. sp 14-16 vimentin Homo sapiens 150-158 26795472-1 2016 Withaferin A (WFA), initially identified as a compound that inhibits experimental angiogenesis, has been shown to bind to soluble vimentin (sVim) and other type III intermediate filament (IF) proteins. withaferin A 0-12 vimentin Homo sapiens 130-138 26795472-1 2016 Withaferin A (WFA), initially identified as a compound that inhibits experimental angiogenesis, has been shown to bind to soluble vimentin (sVim) and other type III intermediate filament (IF) proteins. withaferin A 14-17 vimentin Homo sapiens 130-138 26499837-0 2016 Proteomic Analysis Revealed the Important Role of Vimentin in Human Cervical Carcinoma HeLa Cells Treated With Gambogic Acid. gambogic acid 111-124 vimentin Homo sapiens 50-58 26499837-6 2016 Results of targeted proteomic analysis showed that GA induced change in phosphorylation state of the vimentin head domain (aa51-64). gambogic acid 51-53 vimentin Homo sapiens 101-109 26499837-8 2016 Over-expression of vimentin ameliorated cytotoxicity of GA in HeLa cells. gambogic acid 56-58 vimentin Homo sapiens 19-27 26499837-11 2016 Results of immunohistochemical staining also showed down-regulated vimentin level in tumor xenografts of GA-treated animals. gambogic acid 105-107 vimentin Homo sapiens 67-75 26499837-12 2016 Furthermore, compared with cytotoxicity of GA in HeLa cells, cytotoxicity of GA in MCF-7 cells with low level of vimentin was weaker whereas cytotoxicity of GA in MG-63 cells with high level of vimentin was stronger. gambogic acid 77-79 vimentin Homo sapiens 113-121 26499837-12 2016 Furthermore, compared with cytotoxicity of GA in HeLa cells, cytotoxicity of GA in MCF-7 cells with low level of vimentin was weaker whereas cytotoxicity of GA in MG-63 cells with high level of vimentin was stronger. gambogic acid 77-79 vimentin Homo sapiens 194-202 26499837-12 2016 Furthermore, compared with cytotoxicity of GA in HeLa cells, cytotoxicity of GA in MCF-7 cells with low level of vimentin was weaker whereas cytotoxicity of GA in MG-63 cells with high level of vimentin was stronger. gambogic acid 77-79 vimentin Homo sapiens 113-121 26499837-12 2016 Furthermore, compared with cytotoxicity of GA in HeLa cells, cytotoxicity of GA in MCF-7 cells with low level of vimentin was weaker whereas cytotoxicity of GA in MG-63 cells with high level of vimentin was stronger. gambogic acid 77-79 vimentin Homo sapiens 194-202 26499837-13 2016 These results indicated the important role of vimentin in the cytotoxicity of GA. gambogic acid 78-80 vimentin Homo sapiens 46-54 26499837-14 2016 The effects of GA on vimentin and other epithelial-to-mesenchymal transition (EMT) markers provided suggestion for better usage of GA in clinic. gambogic acid 15-17 vimentin Homo sapiens 21-29 26499837-14 2016 The effects of GA on vimentin and other epithelial-to-mesenchymal transition (EMT) markers provided suggestion for better usage of GA in clinic. gambogic acid 131-133 vimentin Homo sapiens 21-29 26870294-10 2016 Following treatment of AGS cells (which demonstrated the highest methylation level of the vimentin gene) with 5-aza-2"-deoxycytidine, vimentin expression was restored significantly. Decitabine 110-132 vimentin Homo sapiens 90-98 26870294-10 2016 Following treatment of AGS cells (which demonstrated the highest methylation level of the vimentin gene) with 5-aza-2"-deoxycytidine, vimentin expression was restored significantly. Decitabine 110-132 vimentin Homo sapiens 134-142 26261001-5 2015 VIM- and NDM-type metallo-beta-lactamases, OXA-48 and KPC appear as the most successful enzymes and may threaten the efficacy of carbapenems in the near future. Carbapenems 129-140 vimentin Homo sapiens 0-3 27846626-7 2016 CONCLUSIONS: Stimulation of the contralateral VIM/VOP/ZI complex resulted in a noticeable improvement in tremor and recovery of independence in basic daily activities in patients with PTT. Bialaphos 184-187 vimentin Homo sapiens 46-56 26718286-13 2015 Metformin was also associated with a reduction of snail2, twist, and vimentin in CD44(+)CD117(+) ovarian CSCs in vivo. Metformin 0-9 vimentin Homo sapiens 69-77 26471393-11 2015 This significantly enhanced antitumor effect of oAd/DCN/LRP-PEG-NT was mediated by active viral replication and viral spreading, which was facilitated by ECM degradation and inhibition of Wnt signaling-related factors (Wnt, beta-catenin, and/or vimentin) in the tumor tissues. peg-nt 60-66 vimentin Homo sapiens 245-253 26518673-11 2015 Using LC-MS/MS analysis, a nonenaldehyde post-translational modification was identified on Lysine 235 of the cytoskeletal protein vimentin in whole cell extracts prepared from human end stage ALD hepatic tissue. nonenaldehyde 27-40 vimentin Homo sapiens 130-138 26518673-11 2015 Using LC-MS/MS analysis, a nonenaldehyde post-translational modification was identified on Lysine 235 of the cytoskeletal protein vimentin in whole cell extracts prepared from human end stage ALD hepatic tissue. Lysine 91-97 vimentin Homo sapiens 130-138 26563263-12 2015 Interestingly, the expression of vimentin was increased by beta-elemene in vitro; this result was opposite that for the in vivo procedure. beta-elemene 59-71 vimentin Homo sapiens 33-41 26540629-5 2015 The epithelial-mesenchymal transition (EMT) markers, vimentin and Snail, were down-regulated with palbociclib treatment. palbociclib 98-109 vimentin Homo sapiens 53-61 26545962-7 2015 Another 30 genes were up-regulated in EVT compared to CTB including mesenchymal markers such as vimentin (235-fold) and fibronectin (107-fold) as well as the matrix metalloproteinases, MMP2 and MMP9 (357-fold, 129-fold). EVT 38-41 vimentin Homo sapiens 96-104 26156805-7 2015 When cells were treated with si-AEG-1, the expression of p-Erk1/2, p-Akt, vimentin, N-cadherin, and MMP2 was also downregulated. Silicon 29-31 vimentin Homo sapiens 74-82 26695677-4 2015 Protein expression of CK, vimentin, and BMP-7 was also detected in HKCs transfected with lipofectamine contained HOXA13 DNA. Lipofectamine 89-102 vimentin Homo sapiens 26-34 26462028-3 2015 Paclitaxel, one of the cytotoxic taxane-drugs such as docetaxel, increases mesenchymal markers (Vimentin and Fibronectin) and decreases an epithelial marker (Zo-1). Paclitaxel 0-10 vimentin Homo sapiens 96-104 26462028-3 2015 Paclitaxel, one of the cytotoxic taxane-drugs such as docetaxel, increases mesenchymal markers (Vimentin and Fibronectin) and decreases an epithelial marker (Zo-1). Docetaxel 54-63 vimentin Homo sapiens 96-104 26310874-6 2015 Further, resveratrol significantly attenuated drug resistance through inhibition of epithelial-mesenchymal transition (EMT) factors (decreased vimentin and slug, increased E-cadherin) and down-regulation of NF-kappaB activation and its translocation to the nucleus and abolished NF-kappaB-regulated gene end-products (MMP-9, caspase-3). Resveratrol 9-20 vimentin Homo sapiens 143-151 26302188-4 2015 We found that CoCl2 at non-toxic doses induced a mesenchymal cell phenotype in hepatocytes and upregulated several mesenchymal markers including alpha-smooth muscle actin, vimentin, N-cadherin, fibronectin and Snail (an EMT-related transcription factor), but downregulated the epithelial marker E-cadherin in hepatocytes. cobaltous chloride 14-19 vimentin Homo sapiens 172-180 26109569-9 2015 Furthermore, vimentin exchange in ULFs required ATP, and ATP depletion caused a dramatic reduction of the soluble tetramer pool. Adenosine Triphosphate 48-51 vimentin Homo sapiens 13-21 26459909-0 2015 Bisdemethoxycurcumin suppresses migration and invasion of highly metastatic 95D lung cancer cells by regulating E-cadherin and vimentin expression, and inducing autophagy. bisdemethoxycurcumin 0-20 vimentin Homo sapiens 127-135 26459909-7 2015 Furthermore, the expression of vimentin was downregulated, while E-cadherin expression was upregulated in 95D cells treated with BDMC. bisdemethoxycurcumin 129-133 vimentin Homo sapiens 31-39 26331426-0 2015 Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin alpha-2 Expression, and Induce Antitumor Effects against Human Glioma. Hirsutinolide 0-13 vimentin Homo sapiens 78-86 26088755-11 2015 The reduction in E-cad and induction of vim and FN expression by TGF-beta1 or TGF-beta2 were completely reversed by LY2109761 treatment in HCC1806 TNBC cells. LY2109761 116-125 vimentin Homo sapiens 40-43 26170011-5 2015 Expressions of vimentin, CD44(+)/CD24(-), and CD146 were more frequent in basal-like TNBCs than non-basal-like TNBCs. tnbcs 85-90 vimentin Homo sapiens 15-23 26168186-0 2015 The involvement of vimentin in copper-induced regression of cardiomyocyte hypertrophy. Copper 31-37 vimentin Homo sapiens 19-27 26168186-7 2015 Copper supplementation increased vimentin levels and enhanced PKG-1 activity. Copper 0-6 vimentin Homo sapiens 33-41 26168186-8 2015 Gene silencing using siRNA targeting vimentin prevented copper-induced elevation of vimentin, depressed the activity of PKG-1, and blocked the copper-induced regression of cardiomyocyte hypertrophy. Copper 56-62 vimentin Homo sapiens 37-45 26168186-8 2015 Gene silencing using siRNA targeting vimentin prevented copper-induced elevation of vimentin, depressed the activity of PKG-1, and blocked the copper-induced regression of cardiomyocyte hypertrophy. Copper 56-62 vimentin Homo sapiens 84-92 26168186-8 2015 Gene silencing using siRNA targeting vimentin prevented copper-induced elevation of vimentin, depressed the activity of PKG-1, and blocked the copper-induced regression of cardiomyocyte hypertrophy. Copper 143-149 vimentin Homo sapiens 37-45 26134542-7 2015 When CM cells were treated with si-CCR5, the expression of AEG-1, p-Erk1/2, p-Akt, vimentin, N-cadherin and MMP2 was downregulated. Silicon 32-34 vimentin Homo sapiens 83-91 26292717-5 2015 Following chromobody fluorescence in a cancer-relevant cellular model, we were able for the first time to monitor and quantify dynamic changes of endogenous vimentin upon siRNA-mediated knockdown, induction with TGF-beta and modification with Withaferin A by high-content imaging. withaferin A 243-255 vimentin Homo sapiens 157-165 26316699-10 2015 In vitro, RLX decreased the mobility of human umbilical vein endothelial cells induced by TGF-beta, increased the expression of endothelial CD31, and decreased vimentin content. Relaxin 10-13 vimentin Homo sapiens 160-168 26253302-11 2015 The knockdown or knockout of RSK2 in A549 lung cancer cells or MEFs revealed that magnolin targeting ERKs/RSK2 signaling suppressed epithelial-to-mesenchymal transition by modulating EMT marker proteins such as N-cadherin, E-cadherin, Snail, Vimentin and MMPs. magnolin 82-90 vimentin Homo sapiens 242-250 25716692-9 2015 The expression levels of BPTF and vimentin in CRC paraffin-embedded specimens were significantly higher than the expression in NATs (P < 0.01), while the expressions of E-cadherin in tumors were obviously lower than in NATs (P < 0.01). Paraffin 50-58 vimentin Homo sapiens 34-42 26035427-7 2015 In addition, upregulation of miR-153 in HCC cells resulted in a decrease in epithelial markers, E-cadherin and alpha-catenin, and an increase in mesenchymal markers, N-cadherin and vimentin, and vice versa. mir-153 29-36 vimentin Homo sapiens 181-189 25753478-13 2015 Silencing ME1 was noted to inhibit migratory and invasive properties of HCC cells by inducing the E-cadherin expression and decreasing of N-cadherin and vimentin expression in a ROS-dependent pathway. Reactive Oxygen Species 178-181 vimentin Homo sapiens 153-161 26174737-4 2015 Using CoCl2-induced EMT of human breast carcinoma MCF-7 cells, we found that TEPA, a copper chelator, inhibited EMT-like cell morphology and cytoskeleton arrangement triggered by CoCl2; decreased the expression of vimentin and fibronectin, markers typical of EMT; inhibited HIF-1 activation and HIF1-alpha accumulation in nuclear; and down-regulated the expression of hypoxia-associated transcription factors, Snail and Twist1. Triethylenephosphoramide 77-81 vimentin Homo sapiens 214-222 26174737-7 2015 Immunohistochemical analysis of the xenograft further demonstrated that TEPA administration significantly inhibited tumor angiogenesis, down-regulated hypoxia-induced transcription factors, Snail and Twist1, leading to decreased transactivation of EMT-associated marker genes, vimentin and fibronectin. Triethylenephosphoramide 72-76 vimentin Homo sapiens 277-285 26109569-0 2015 Vimentin filament precursors exchange subunits in an ATP-dependent manner. Adenosine Triphosphate 53-56 vimentin Homo sapiens 0-8 26124325-10 2015 We detected an alteration of expression of vimentin and E-cadherin level after treatment with lapatinib and gefitinib. Lapatinib 94-103 vimentin Homo sapiens 43-51 26124325-10 2015 We detected an alteration of expression of vimentin and E-cadherin level after treatment with lapatinib and gefitinib. Gefitinib 108-117 vimentin Homo sapiens 43-51 26248740-8 2015 Moreover, SNAI siRNA upregulated the expression of epithelial marker E-cadherin, but attenuated the expression of mesenchymal marker alpha-smooth muscle actin and vimentin in silica-stimulated cells. Silicon Dioxide 175-181 vimentin Homo sapiens 163-171 26129776-0 2015 Beta-cell regeneration from vimentin+/MafB+ cells after STZ-induced extreme beta-cell ablation. Streptozocin 56-59 vimentin Homo sapiens 28-36 26129776-6 2015 Strikingly, intermediate cells lacking epithelial marker E-cadherin but expressing mesenchymal cell-specific marker vimentin appeared within 16 hrs following STZ exposure, which served as the major source of insulin-producing cells observed at 24 hrs. Streptozocin 158-161 vimentin Homo sapiens 116-124 25681634-7 2015 Analogously, distribution of ORP4L-VAPA complexes between the plasma membrane and vimentin intermediate filament associated compartments was modified by statin or 25OHC treatment. 25ohc 163-168 vimentin Homo sapiens 82-90 26463323-10 2015 The results of Western blot analysis showed that the expression of p-EGFR, p-cMet, p-AKT, p-ERK, vimentin and snail in H1975AR cells treated with bufalin puls afatinb was down-regulated markedly, and the expression of E-cadherin was up-regulated markedly. bufalin 146-153 vimentin Homo sapiens 97-105 25813406-6 2015 17-DMCHAG exhibits anti-invasive and anti-migratory activities in prostate cancer cells through down-regulating of transcription factors Zeb1, Snail1, Slug, and mesenchymal marker Vimentin, while up-regulating the epithelial marker of E-cadherin. 17-(6-(3,4-dimethoxycinnamamido)hexylamino)-17-demethoxy-geldanamycin 0-9 vimentin Homo sapiens 180-188 26135834-5 2015 The predicted targeting of miR-138-5p on vimentin (VIM) was assessed by western blotting in PANC-1 cells. mir-138-5p 27-37 vimentin Homo sapiens 41-49 26135834-5 2015 The predicted targeting of miR-138-5p on vimentin (VIM) was assessed by western blotting in PANC-1 cells. mir-138-5p 27-37 vimentin Homo sapiens 51-54 26135834-11 2015 Western blotting demonstrated that VIM was downregulated upon the upregulation of miR-138-5p in PANC-1 cells. mir-138-5p 82-92 vimentin Homo sapiens 35-38 26254990-5 2015 Treatment with Ponatinib resulted in a reduction of EMT in A549 cells with a decrease in vimentin and p-Smad3, whereas an increase in E-cadherin. ponatinib 15-24 vimentin Homo sapiens 89-97 26216510-7 2015 Exposure of ciPTEC to pCG caused epithelial-to-mesenchymal transition, indicated by increased expression of vimentin and Bcl-2, and diminished E-cadherin. ciptec 12-18 vimentin Homo sapiens 108-116 26216510-7 2015 Exposure of ciPTEC to pCG caused epithelial-to-mesenchymal transition, indicated by increased expression of vimentin and Bcl-2, and diminished E-cadherin. 4-cresylglucuronide 22-25 vimentin Homo sapiens 108-116 25904701-8 2015 Multiple logistic regression and receiver-operating characteristics analysis further showed that urine VIM mRNA is the best predictive parameter of renal fibrosis compared with estimated glomerular filtration rate, serum creatinine, and blood urea nitrogen. Creatinine 221-231 vimentin Homo sapiens 103-106 25904701-8 2015 Multiple logistic regression and receiver-operating characteristics analysis further showed that urine VIM mRNA is the best predictive parameter of renal fibrosis compared with estimated glomerular filtration rate, serum creatinine, and blood urea nitrogen. Nitrogen 248-256 vimentin Homo sapiens 103-106 26337028-11 2015 Among ACPA specificites, anti-cit-vimentin (amino acids 60-75) was associated with higher RANKL concentration and higher prevalence of bone erosion (p <0.05). cit 18-21 vimentin Homo sapiens 34-42 26337028-13 2015 CONCLUSIONS: RANKL was elevated in ACPA-positive and in anti-cit-vimentin-positive patients with early untreated RA and associated with bone erosions. cit 61-64 vimentin Homo sapiens 65-73 26690867-7 2015 We also demonstrated reduction of Vimentin with DOX-HA-SPION which is significantly less than both control and DOX. Doxorubicin 48-51 vimentin Homo sapiens 34-42 26690867-7 2015 We also demonstrated reduction of Vimentin with DOX-HA-SPION which is significantly less than both control and DOX. histidinoalanine 52-54 vimentin Homo sapiens 34-42 26690867-7 2015 We also demonstrated reduction of Vimentin with DOX-HA-SPION which is significantly less than both control and DOX. spion 55-60 vimentin Homo sapiens 34-42 26690867-7 2015 We also demonstrated reduction of Vimentin with DOX-HA-SPION which is significantly less than both control and DOX. Doxorubicin 111-114 vimentin Homo sapiens 34-42 24729530-7 2015 Notably, As(2)O(3) induces an MET in vitro and in vivo, as determined by the increased expression of the epithelial marker, E-cadherin and decreased expressions of mesenchymal markers, N-cadherin and vimentin. (2)o(3) 11-18 vimentin Homo sapiens 200-208 26396670-7 2015 Notably, the EMT marker E-cadherin or vimentin, a downstream of Sox4, was also down-regulated or upregulated upon miR-133a treatment. mir-133a 114-122 vimentin Homo sapiens 38-46 26031447-0 2015 Vimentin filament organization and stress sensing depend on its single cysteine residue and zinc binding. Cysteine 71-79 vimentin Homo sapiens 0-8 26236052-1 2015 Nitrosation and cyclization of 4-(3-aminothieno[2,3-b]pyridine-2-yl)-2H-chromen-2-ones 1 afforded substituted 6H-chromeno[3,4-c]pyrido[3",2":4,5]thieno[2,3-e]pyridazin-6-ones 2 that inhibited the intermediary filament protein, vimentin, at low micromolar concentrations. 4-(3-aminothieno[2,3-b]pyridine-2-yl)-2h-chromen-2-ones 31-86 vimentin Homo sapiens 227-235 26031447-3 2015 Here we show that C328 is essential for vimentin network reorganization in response to oxidants and electrophiles, and is required for optimal vimentin performance in network expansion, lysosomal distribution and aggresome formation. c328 18-22 vimentin Homo sapiens 40-48 26236052-1 2015 Nitrosation and cyclization of 4-(3-aminothieno[2,3-b]pyridine-2-yl)-2H-chromen-2-ones 1 afforded substituted 6H-chromeno[3,4-c]pyrido[3",2":4,5]thieno[2,3-e]pyridazin-6-ones 2 that inhibited the intermediary filament protein, vimentin, at low micromolar concentrations. 6h-chromeno[3,4-c]pyrido[3",2":4,5]thieno[2,3-e]pyridazin-6-ones 110-174 vimentin Homo sapiens 227-235 26031447-3 2015 Here we show that C328 is essential for vimentin network reorganization in response to oxidants and electrophiles, and is required for optimal vimentin performance in network expansion, lysosomal distribution and aggresome formation. c328 18-22 vimentin Homo sapiens 143-151 26031447-5 2015 In vitro, micromolar zinc protects vimentin from iodoacetamide modification and elicits vimentin polymerization into optically detectable structures; in cells, zinc closely associates with vimentin and its depletion causes reversible filament disassembly. Iodoacetamide 49-62 vimentin Homo sapiens 35-43 26031447-7 2015 These results unveil a critical role of C328 in vimentin organization and open new perspectives for the regulation of intermediate filaments by zinc. c328 40-44 vimentin Homo sapiens 48-56 25792283-5 2015 Pterostilbene inhibited the migratory and invasive potential of triple-negative MDA-MB-231 and Hs578t cells, accompanied by the up-regulation of E-cadherin and down-regulation of Snail, Slug, vimentin and ZEB1. pterostilbene 0-13 vimentin Homo sapiens 192-200 25855378-6 2015 Consistent with its role as an intermediate filament, vimentin acted as a scaffold to recruit Slug to ERK and promote Slug phosphorylation at serine-87. Serine 142-148 vimentin Homo sapiens 54-62 24293234-0 2015 Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors. withaferin A 0-12 vimentin Homo sapiens 101-109 25811972-7 2015 Consistently, flubendazole reduced mesenchymal markers (beta-catenin, N-cadherin and Vimentin) expression and induced epithelial and differentiation marker (Keratin 18) expression in breast cancer cells. flubendazole 14-26 vimentin Homo sapiens 85-93 25813246-5 2015 TSA or VPA induced mesenchymal features in the colon carcinoma cells by a decrease in E-cadherin and an increase in vimentin expression at the mRNA and protein levels. trichostatin A 0-3 vimentin Homo sapiens 116-124 25813246-5 2015 TSA or VPA induced mesenchymal features in the colon carcinoma cells by a decrease in E-cadherin and an increase in vimentin expression at the mRNA and protein levels. Valproic Acid 7-10 vimentin Homo sapiens 116-124 25923074-4 2015 When cultured with CS, all fibroblasts grew perpendicular to the force and exhibited a decreased cell projection area, cell circularity and increased cell length/width ratio; normal fibroblasts exhibited increased RFIs of all three types of cytoskeleton, and POP fibroblasts exhibited a decreased RFI of F-actin and no significant differences of alpha-tubulin and vimentin. Cesium 19-21 vimentin Homo sapiens 364-372 25895672-4 2015 RESULTS: The exposure of 20 muM H2O2 for 72 h accelerated E-cadherin loss and vimentin induction in airway epithelial BEAS-2B cells, which was reversed by non-toxic astragalin at 1-20 muM. Hydrogen Peroxide 32-36 vimentin Homo sapiens 78-86 25757908-5 2015 By using wound healing and transwell chamber migration assays, we found that benzidine could increase SV-HUC-1 cells invasion activity, western blotting and Immunofluorescence showed that the expression levels of Snail, beta-catenin, Vimentin, and MMP-2 were significantly increased, while, the expression levels of E-cadherin, ZO-1 were decreased. benzidine 77-86 vimentin Homo sapiens 234-242 25938472-6 2015 Injection of GB1101 completely inhibited hypertrophic scar formation at 35 days post-incision and inhibited cellular infiltration, TGF-beta1 and vimentin staining, and epidermal thickness. gb1101 13-19 vimentin Homo sapiens 145-153 25938472-10 2015 FITC-labeled GB1101 with solbase most efficiently distributed in the nuclei of epidermal keratinocytes, completely suppressed hypertropic scarring at 42 days after incision, and considerably inhibited epidermal thickness and vimentin-positive fibroblasts. Fluorescein-5-isothiocyanate 0-4 vimentin Homo sapiens 225-233 25797437-4 2015 Further, BPA treatment increased the expression of metalloproteinase-9 (MMP-9) and fibronectin (FN) in both HeLa and SiHa cells, while did not obviously change the expression of MMP-2, vimentin (Vim) or N-Cadherin (N-Cad). bisphenol A 9-12 vimentin Homo sapiens 195-198 25690688-5 2015 The expressions of snail, slug, and vimentin were enhanced by the treatment of E2, BPA, or NP compared to a control (DMSO). Dimethyl Sulfoxide 117-121 vimentin Homo sapiens 36-44 25940539-8 2015 The anticancer effect of CUDC-101 was associated with increased expression of p21 and E-cadherin, and reduced expression of survivin, XIAP, beta-catenin, N-cadherin, and Vimentin. 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide 25-33 vimentin Homo sapiens 170-178 25884955-7 2015 Infiltration of TAMs was also correlated with overexpression of vimentin, smooth muscle actin and alteration of beta-catenin. tams 16-20 vimentin Homo sapiens 64-72 24243709-4 2015 In three cell lines, genistein enhanced E-cadherin and alpha-catenin, but reduced N-cadherin and Vimentin at both mRNA and protein levels in a dose-dependent manner. Genistein 21-30 vimentin Homo sapiens 97-105 24243709-7 2015 Phorbol 12-myristate 13-acetate (PMA) and ionomycin enhanced activity of NFAT1, reduced E-cadherin and alpha-catenin protein levels, and increased protein levels of N-cadherin and Vimentin. Tetradecanoylphorbol Acetate 0-31 vimentin Homo sapiens 180-188 24243709-7 2015 Phorbol 12-myristate 13-acetate (PMA) and ionomycin enhanced activity of NFAT1, reduced E-cadherin and alpha-catenin protein levels, and increased protein levels of N-cadherin and Vimentin. Tetradecanoylphorbol Acetate 33-36 vimentin Homo sapiens 180-188 24243709-7 2015 Phorbol 12-myristate 13-acetate (PMA) and ionomycin enhanced activity of NFAT1, reduced E-cadherin and alpha-catenin protein levels, and increased protein levels of N-cadherin and Vimentin. Ionomycin 42-51 vimentin Homo sapiens 180-188 25600647-3 2015 Here, we demonstrate that the scaffolding protein beta-arrestin-1 is necessary for nicotine-mediated induction of mesenchymal genes vimentin and fibronectin as well as EMT regulators ZEB1 and ZEB2. Nicotine 83-91 vimentin Homo sapiens 132-140 25600647-6 2015 Stimulation of multiple NSCLC cell lines with nicotine led to enhanced recruitment of beta-arrestin-1 and E2F1 on vimentin, fibronectin, and ZEB1 and ZEB2 promoters. Nicotine 46-54 vimentin Homo sapiens 114-122 25884904-14 2015 But resveratrol could inhibit the invasive and migratory ability of LoVo cells in a concentration-dependent manner, increase the expression of E-cadherin, repress the expression of Vimentin, as well as the inhibition of TGF-beta1/Smads signaling pathway. Resveratrol 4-15 vimentin Homo sapiens 181-189 25742642-4 2015 Cotreatment with troglitazone and lovastatin altered the epithelial-to-mesenchymal-transition (EMT) -related marker gene expression of the cells; specifically, E-cadherin expression increased and vimentin expression decreased. Troglitazone 17-29 vimentin Homo sapiens 196-204 25742642-4 2015 Cotreatment with troglitazone and lovastatin altered the epithelial-to-mesenchymal-transition (EMT) -related marker gene expression of the cells; specifically, E-cadherin expression increased and vimentin expression decreased. Lovastatin 34-44 vimentin Homo sapiens 196-204 25406472-7 2015 Under the pressure of 0.5 microM Cr(VI), senescent fibroblasts promoted the acquisition of mesenchymal features on BEAS-2B cells, e.g. the fusiform shape and increased Vimentin expression, consistent with the occurrence of an epithelial-mesenchymal transition-like process. Chromium 33-35 vimentin Homo sapiens 168-176 25404709-2 2015 This increase is detected by quantitatively comparing the fluorescence intensity of mitochondria stained with the membrane potential-sensitive dye tetramethylrhodamine-ethyl ester (TMRE) in murine vimentin-null fibroblasts with that in the same cells expressing human vimentin (~35% rise). tetramethyl rhodamine ethyl ester 181-185 vimentin Homo sapiens 268-276 25661250-7 2015 TCs were identified by several immunofluorescence stainings including double labelling for CD34 and c-kit/CD117, or vimentin, or PDGF Receptor-alpha, or beta. Technetium 0-3 vimentin Homo sapiens 116-124 25733818-11 2015 Moreover, Danu inhibited EMT in both MCF7 and MDA-MB-231 cells with upregulated E-cadherin and zona occludens protein 1 (ZO-1) but downregulated N-cadherin, zinc finger E-box-binding homeobox 1 (TCF8/ZEB1), snail, slug, vimentin, and beta-catenin. danusertib 10-14 vimentin Homo sapiens 220-228 25582705-5 2015 PA treatment resulted in a reduction of EMT in A549 cells with a decrease in vimentin and HMGB, an increase of E-cadherin and RAGE, a reduction of HLF-1 proliferation with a decrease of fibroblast growth factor 2 (FGF-2) and platelet-derived growth factor (PDGF). protocatechualdehyde 0-2 vimentin Homo sapiens 77-85 25678802-10 2015 In addition, upregulation of miR-153 reduced SNAI1 expression and subsequently suppressed epithelial-mesenchymal transition (EMT) with elevated expression of E-cadherin and reduced expression of vimentin in MKN-45 cells. mir-153 29-36 vimentin Homo sapiens 195-203 25592371-6 2015 The results showed that (+)-terrein inhibited the growth of Bel-7402 cells with alterations in cell morphology and a reduced transcript expression of cell morphology genes (fibronectin, N-cadherin, and vimentin). terrein 24-35 vimentin Homo sapiens 202-210 25448402-5 2015 Disruption of vimentin cytoskeleton by treatment with withaferin A, a natural steroidal lactone, suppressed not only the adhesion of ATL cells to the feeder layer but also subsequent Ad-MCA formation by ATL cells, suggesting the involvement of vimentin in anchoring ATL cells to the feeder layer. withaferin A 54-66 vimentin Homo sapiens 14-22 25448402-5 2015 Disruption of vimentin cytoskeleton by treatment with withaferin A, a natural steroidal lactone, suppressed not only the adhesion of ATL cells to the feeder layer but also subsequent Ad-MCA formation by ATL cells, suggesting the involvement of vimentin in anchoring ATL cells to the feeder layer. withaferin A 54-66 vimentin Homo sapiens 244-252 25448402-5 2015 Disruption of vimentin cytoskeleton by treatment with withaferin A, a natural steroidal lactone, suppressed not only the adhesion of ATL cells to the feeder layer but also subsequent Ad-MCA formation by ATL cells, suggesting the involvement of vimentin in anchoring ATL cells to the feeder layer. Lactones 88-95 vimentin Homo sapiens 14-22 25256953-7 2015 RESULTS: We have found that IFC-CAF does not promote proliferation but induces migration of HaCaT, HDF and SHDF in a time- and dose-dependent manner; a better organization of cytoskeletal proteins (F-actin and vimentin) and promotes the production of extracellular components (fibronectin, collagen 1 and MMPs) and the adhesion to cell-substrate vinculin protein. ifc-caf 28-35 vimentin Homo sapiens 210-218 25544037-1 2015 In the present work, we have investigated the effect of cotinine, the major metabolite of nicotine on the A549 and T24 cell lines in the context of structural and quantitative changes of F-actin, gelsolin and vimentin. Cotinine 56-64 vimentin Homo sapiens 209-217 25544037-8 2015 We have also found that in A549 cells, but not in T24 cell line, cotinine acted stimulating on the vimentin filament network. Cotinine 65-73 vimentin Homo sapiens 99-107 25991546-10 2015 In the PANC-1 cells that survived after TSA treatment, the expression levels of vimentin, E-cadherin, and MMP genes were altered by the promotion of potential metastasis and increased expression of NICD. trichostatin A 40-43 vimentin Homo sapiens 80-88 25660287-11 2015 Results of Western blotting confirmed the cleavage of vimentin, increase in keratin 18, and decrease in calumenin levels in GA-treated cells. gambogic acid 124-126 vimentin Homo sapiens 54-62 25600626-4 2015 Citrulline and homocitrulline residues in enolase and vimentin were analysed by partial purification by gel electrophoresis followed by mass spectrometry in 12 of the lung samples and one from each control tissues. Citrulline 0-10 vimentin Homo sapiens 54-62 25600626-4 2015 Citrulline and homocitrulline residues in enolase and vimentin were analysed by partial purification by gel electrophoresis followed by mass spectrometry in 12 of the lung samples and one from each control tissues. homocitrulline 15-29 vimentin Homo sapiens 54-62 25560632-12 2015 We observe that MC and NCSC are able to increase expression of keratins 8, 14, 19, and vimentin in the co-cultured HPK. Methylcholanthrene 16-18 vimentin Homo sapiens 87-95 25434997-4 2015 TSA-induced EMT reversal was characterized by up-regulation of E-cadherin and down-regulation of Vimentin. trichostatin A 0-3 vimentin Homo sapiens 97-105 26632346-8 2015 The inhibitor of PI3K/Akt, LY2994002, significantly attenuates VPA induced phosphorylation of Akt and GSK-3beta and up regulation of Snail and Vim. ly2994002 27-36 vimentin Homo sapiens 143-146 26632346-8 2015 The inhibitor of PI3K/Akt, LY2994002, significantly attenuates VPA induced phosphorylation of Akt and GSK-3beta and up regulation of Snail and Vim. Valproic Acid 63-66 vimentin Homo sapiens 143-146 25967959-7 2015 RESULTS: Spironolactone significantly prevented TGF-beta-stimulated EndMT by down-regulate vimentin and up-regulate CD31 in HUVECs (p<0.01).It inhibited cell migration during EndMT (p<0.01). Spironolactone 9-23 vimentin Homo sapiens 91-99 25488711-1 2015 AIM: To evaluate the prevalence and diagnostic significance of the autoantibody against citrullinated vimentin (anti-Sa) compared with the widely used anti-cyclic citrullinated peptide autoantibody (anti-CCP) in patients with rheumatoid arthritis (RA). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 117-119 vimentin Homo sapiens 102-110 25488183-0 2015 Enoxaparin sensitizes human non-small-cell lung carcinomas to gefitinib by inhibiting DOCK1 expression, vimentin phosphorylation, and Akt activation. Enoxaparin 0-10 vimentin Homo sapiens 104-112 25488183-0 2015 Enoxaparin sensitizes human non-small-cell lung carcinomas to gefitinib by inhibiting DOCK1 expression, vimentin phosphorylation, and Akt activation. Gefitinib 62-71 vimentin Homo sapiens 104-112 25488183-12 2015 Western blot verified the effective inhibition of the expression of DOCK1 and vimentin phosphorylation by enoxaparin + gefitinib compared with gefitinib alone. Gefitinib 119-128 vimentin Homo sapiens 78-86 25488183-12 2015 Western blot verified the effective inhibition of the expression of DOCK1 and vimentin phosphorylation by enoxaparin + gefitinib compared with gefitinib alone. Gefitinib 143-152 vimentin Homo sapiens 78-86 25488183-14 2015 Our data indicate that enoxaparin sensitizes gefitinib antitumor and antimigration activity in lung cancer by suppressing DOCK1 expression, Akt activity, and vimentin phosphorylation. Enoxaparin 23-33 vimentin Homo sapiens 158-166 25531265-5 2015 This was confirmed by that 6-OH-BDE-47 significantly down regulated the expression of epithelial markers E-cadherin (E-Cad) and zona occludin-1 (ZO-1) while up regulated the mesenchymal markers vimentin (Vim) and N-cadherin (N-Cad). 6-oh-bde 27-35 vimentin Homo sapiens 194-202 25531265-5 2015 This was confirmed by that 6-OH-BDE-47 significantly down regulated the expression of epithelial markers E-cadherin (E-Cad) and zona occludin-1 (ZO-1) while up regulated the mesenchymal markers vimentin (Vim) and N-cadherin (N-Cad). 6-oh-bde 27-35 vimentin Homo sapiens 204-207 26819576-2 2015 The vimentin cytoskeleton in SCs is disrupted by dibutyl phthalate (DBP), which leads to SCs dysfunction. Dibutyl Phthalate 49-66 vimentin Homo sapiens 4-12 26819576-2 2015 The vimentin cytoskeleton in SCs is disrupted by dibutyl phthalate (DBP), which leads to SCs dysfunction. Dibutyl Phthalate 68-71 vimentin Homo sapiens 4-12 26819576-6 2015 The real-time PCR and ChIP-qPCR results showed that SB431542 (an inhibitor of Smad2/3) could significantly attenuate the expression of vimentin induced by DBP in SCs. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 52-60 vimentin Homo sapiens 135-143 26819576-7 2015 Phosphorylated and soluble vimentin were both downregulated by SB431542 pretreatment. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 63-71 vimentin Homo sapiens 27-35 26819576-8 2015 WY14643 (an agonist of PPARalpha) pretreatment stimulated, while GW6471 (an antagonist of PPARalpha) inhibited, the activity of Smad2/3; SB431542 pretreatment also inhibited the activity of PPARalpha, but it did not rescue the DBP-induced collapse in vimentin. pirinixic acid 0-7 vimentin Homo sapiens 251-259 26819576-8 2015 WY14643 (an agonist of PPARalpha) pretreatment stimulated, while GW6471 (an antagonist of PPARalpha) inhibited, the activity of Smad2/3; SB431542 pretreatment also inhibited the activity of PPARalpha, but it did not rescue the DBP-induced collapse in vimentin. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 137-145 vimentin Homo sapiens 251-259 25446094-2 2014 HMA inhibited cell growth and migration concomitantly with increase of E-cadherin as well as decrease of N-cadherin and vimentin. herbimycin 0-3 vimentin Homo sapiens 120-128 25446094-4 2014 In HMA-treated condition, knockdown of E-cadherin and overexpression of p53 increased N-cadherin and vimentin, and mitigated the inhibitory effects of HMA on cell growth and migration. herbimycin 3-6 vimentin Homo sapiens 101-109 25301710-5 2014 Anti-VIM antibodies (AVAs) were significantly increased in 11 of 27 patients (40.7%) with APS. avas 21-25 vimentin Homo sapiens 5-8 25356787-7 2014 Real-time RT-PCR showed whereas both Shh and DHT induced N-cadherin and vimentin, DHT also induced the expression of osteonectin in LNCaP and cyclopamine blocked these expressions in osteonectin, N-cadherin and vimentin (p = 0.0084, 0.0002 and 0.0373, respectively). Dihydrotestosterone 45-48 vimentin Homo sapiens 72-80 25356787-7 2014 Real-time RT-PCR showed whereas both Shh and DHT induced N-cadherin and vimentin, DHT also induced the expression of osteonectin in LNCaP and cyclopamine blocked these expressions in osteonectin, N-cadherin and vimentin (p = 0.0084, 0.0002 and 0.0373, respectively). Dihydrotestosterone 45-48 vimentin Homo sapiens 211-219 25356787-7 2014 Real-time RT-PCR showed whereas both Shh and DHT induced N-cadherin and vimentin, DHT also induced the expression of osteonectin in LNCaP and cyclopamine blocked these expressions in osteonectin, N-cadherin and vimentin (p = 0.0084, 0.0002 and 0.0373, respectively). Dihydrotestosterone 82-85 vimentin Homo sapiens 211-219 25356787-7 2014 Real-time RT-PCR showed whereas both Shh and DHT induced N-cadherin and vimentin, DHT also induced the expression of osteonectin in LNCaP and cyclopamine blocked these expressions in osteonectin, N-cadherin and vimentin (p = 0.0084, 0.0002 and 0.0373, respectively). cyclopamine 142-153 vimentin Homo sapiens 72-80 25356787-7 2014 Real-time RT-PCR showed whereas both Shh and DHT induced N-cadherin and vimentin, DHT also induced the expression of osteonectin in LNCaP and cyclopamine blocked these expressions in osteonectin, N-cadherin and vimentin (p = 0.0084, 0.0002 and 0.0373, respectively). cyclopamine 142-153 vimentin Homo sapiens 211-219 25464508-6 2014 In contrast, SB431542 addition downregulated the expression of N-cadherin and Vimentin, but upregulated the expression of E-cadherin. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 13-21 vimentin Homo sapiens 78-86 25152370-6 2014 CLG induced the expression of the mesenchymal marker vimentin in MCF-7 cells, but not in MDA-MB-231 cells. Clorgyline 0-3 vimentin Homo sapiens 53-61 25269990-6 2014 TSA was found to induce mesenchymal-like morphological changes in BGC-823 human gastric cancer and MCF-7 breast cancer cells, and increase the expression levels of the mesenchymal markers Vimentin and Twist. trichostatin A 0-3 vimentin Homo sapiens 188-196