PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31308408-4	2019	C. elegans, loss of function in SLO-1, the BK channel ortholog, confers profound ethanol resistance in movement and egg-laying behaviors.	Ethanol	81-88	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	32-37
31308408-5	2019	Here, we show that depletion of SLO-1 channels clustered at the active zones with no change in the overall channel expression level results in locomotory resistance to the intoxicating effect of ethanol, equivalent to that of slo-1 loss-of-function mutants.	Ethanol	195-202	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	32-37
31308408-6	2019	Likewise, depletion of clustered SLO-1 channels in the sarcolemma and neurons leads to ethanol-resistant egg-laying behavior.	Ethanol	87-94	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	33-38
31308408-7	2019	By contrast, reduction in the overall SLO-1 channel level by over 70% causes only moderate ethanol resistance in movement, and minimal, if any, resistance in egg laying.	Ethanol	91-98	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	38-43
25008572-4	2014	In this article, we review the roles of BK channels (also called SLO-1), the lipid microenvironment, receptors, the synaptic machinery, and neurotransmitters in both the acute and chronic effects of alcohol.	Alcohols	199-206	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	65-70
27238266-2	2016	Brief (several minutes) ethanol exposure usually leads to increased BK current, which results from ethanol interaction with a pocket mapped to the BK channel-forming slo1 protein cytosolic tail domain.	Ethanol	24-31	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	166-170
27238266-2	2016	Brief (several minutes) ethanol exposure usually leads to increased BK current, which results from ethanol interaction with a pocket mapped to the BK channel-forming slo1 protein cytosolic tail domain.	Ethanol	99-106	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	166-170
27238266-3	2016	The importance of this region in ethanol-induced intoxication has been independently supported by an unbiased screen of Caenorhabditis elegans slo1 mutants.	Ethanol	33-40	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	143-147
25249984-4	2014	The BK channel, slo-1, was identified in a forward genetics screen as a major ethanol target in C. elegans for the effects of ethanol on locomotion and egg-laying behaviors.	Ethanol	78-85	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	16-21
25249984-4	2014	The BK channel, slo-1, was identified in a forward genetics screen as a major ethanol target in C. elegans for the effects of ethanol on locomotion and egg-laying behaviors.	Ethanol	126-133	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	16-21
28546434-3	2017	Using the nematode Caenorhabditis elegans, we tested whether one highly conserved ethanol target, the large-conductance, calcium-activated potassium channel (known as the BK channel or Slo1), modulates ethanol withdrawal.	Ethanol	82-89	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	185-189
28546434-3	2017	Using the nematode Caenorhabditis elegans, we tested whether one highly conserved ethanol target, the large-conductance, calcium-activated potassium channel (known as the BK channel or Slo1), modulates ethanol withdrawal.	Ethanol	202-209	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	185-189
28546434-7	2017	Consistent with these results, we found that chronic ethanol exposure decreased SLO-1 expression in a subset of neurons.	Ethanol	53-60	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	80-85
26771544-4	2016	Activation of vertebrate SLO-1 channels causes transient membrane hyperpolarization, which makes it an important negative feedback system for calcium entry through voltage-activated calcium channels.	Calcium	142-149	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	25-30
26771544-6	2016	We also show for the first time that slo-2 BK channels are important for AWC asymmetry and act redundantly with slo-1 to inhibit calcium signaling.	Calcium	129-136	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	112-117
26113050-7	2015	Consistent with these behavioral results, we found that ethanol activated the SLO-1 channel in vitro with or without these domains.	Ethanol	56-63	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	78-83
26113050-9	2015	Thus, for the worm SLO-1 channel, the putative calcium-sensitive domains are critical for basal in vivo function but unnecessary for in vivo ethanol action.	Calcium	47-54	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	19-24
26113050-9	2015	Thus, for the worm SLO-1 channel, the putative calcium-sensitive domains are critical for basal in vivo function but unnecessary for in vivo ethanol action.	Ethanol	141-148	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	19-24
25779980-7	2015	Depending on the subunit composition, channels might have altered physiological and pharmacological properties including different modulation by calcium and/or voltage or reduced emodepside susceptibility which might lead to emodepside resistance as observed in Caenorhabditis elegans expressing only similarly truncated Slo-1.	Calcium	145-152	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	321-326
20454655-9	2010	The potassium channel, slo-1, which is a candidate ethanol effector in C. elegans, is not required for the responses described here.	Ethanol	51-58	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	23-28
23707730-8	2013	Moreover, the slo-1 mutant strain (completely emodepside resistant) also showed hypersusceptibility to piperazine.	Piperazine	103-113	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	14-19
23882127-0	2013	Distinct molecular targets including SLO-1 and gap junctions are engaged across a continuum of ethanol concentrations in Caenorhabditis elegans.	Ethanol	95-102	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	37-42
23882127-6	2013	We investigated two candidate ethanol effectors, the calcium-activated K(+) channel SLO-1 and gap junctions, and show that they contribute to, but are not sole determinants of, the low- and high-concentration effects, respectively.	Ethanol	30-37	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	84-89
25031399-2	2014	In the nematode Caenorhabditis elegans, mutations that eliminate the BK channel, SLO-1, convey dramatic resistance to intoxication by ethanol.	Ethanol	134-141	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	81-86
23590941-2	2013	Among them, the Slo1 and C. elegans SLO-2 channels are gated by calcium (Ca ( 2+) ), while mammalian Slo2 channels are activated by both sodium (Na (+) ) and chloride (Cl (-) ).	Calcium	64-71	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	16-20
23590941-2	2013	Among them, the Slo1 and C. elegans SLO-2 channels are gated by calcium (Ca ( 2+) ), while mammalian Slo2 channels are activated by both sodium (Na (+) ) and chloride (Cl (-) ).	Sodium	137-143	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	16-20
23590941-2	2013	Among them, the Slo1 and C. elegans SLO-2 channels are gated by calcium (Ca ( 2+) ), while mammalian Slo2 channels are activated by both sodium (Na (+) ) and chloride (Cl (-) ).	Chlorides	158-166	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	16-20
21945072-6	2012	Mutants of the slo-1, rab-3 and unc-64 genes that are resistant to ethanol or the volatile anesthetic halothane show no resistance to toluene.	Ethanol	67-74	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	15-20
21945072-6	2012	Mutants of the slo-1, rab-3 and unc-64 genes that are resistant to ethanol or the volatile anesthetic halothane show no resistance to toluene.	Halothane	102-111	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	15-20
22574115-7	2012	Finally, we found that genetic alterations in the levels of the TAG lipase LIPS-7 can modify the phenotype of gain-of-function mutations in the ethanol-inducible ion channel SLO-1, the voltage- and calcium-sensitive BK channel.	Ethanol	144-151	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	174-179
20865173-9	2010	Our results demonstrate that CTN-1 ensures the localization of SLO-1 within calcium nanodomains, thereby playing a crucial role in muscles and neurons.	Calcium	76-83	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	63-68
20019812-8	2009	Consistent with observations that SLO-1 requires a high calcium concentration for full activation, we find that SLO-1 is localized near L-type calcium channels in muscle, thereby providing a mechanism coupling calcium influx with the outward rectifying current.	Calcium	56-63	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	34-39
20019812-8	2009	Consistent with observations that SLO-1 requires a high calcium concentration for full activation, we find that SLO-1 is localized near L-type calcium channels in muscle, thereby providing a mechanism coupling calcium influx with the outward rectifying current.	Calcium	143-150	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	112-117
20019812-9	2009	Our results indicate that the DAPC modulates muscle excitability by localizing the SLO-1 channel to calcium-rich regions of C. elegans muscle.	Calcium	100-107	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	83-88
15514057-7	2004	The slo-1 and egl-30 mutations conferred resistance to VAs, but unc-43 mutations did not.	vas	55-58	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	4-9
17583712-0	2007	The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans.	cyclo-octadepsipeptide	88-110	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	41-46
17583712-0	2007	The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans.	emodepside	125-135	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	41-46
16527307-2	2006	SLO-1 has been shown to be involved in neurotransmitter release and ethanol response.	Ethanol	68-75	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	0-5
17850640-8	2007	Furthermore, C. elegans slo1 null mutants are resistant to ethanol-induced motor incoordination.	Ethanol	59-66	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	24-28
14675531-3	2003	We found that slo-1 mutants, which were previously recognized as having slightly uncoordinated movement, are highly resistant to ethanol in two behavioral assays.	Ethanol	129-136	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	14-19
15374666-1	2004	A genetic screen for resistance to ethanol intoxication in Caenorhabditis elegans isolated mutants of the gene slo-1.	Ethanol	35-42	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	111-116
15374666-3	2004	Electrophysiological data recorded in vivo are consistent with a model in which ethanol potentiation of SLO-1 produces intoxication in C. elegans by reducing excitatory neurotransmitter release.	Ethanol	80-87	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	104-109
14675531-4	2003	Numerous loss-of-function slo-1 alleles emerged from our screens, indicating that slo-1 has a central role in ethanol responses.	Ethanol	110-117	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	26-31
14675531-4	2003	Numerous loss-of-function slo-1 alleles emerged from our screens, indicating that slo-1 has a central role in ethanol responses.	Ethanol	110-117	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	82-87
14675531-7	2003	Moreover, behaviors of slo-1 gain-of-function mutants resemble those of ethanol-intoxicated animals.	Ethanol	72-79	BK channel;Calcium-activated potassium channel slo-1	Caenorhabditis elegans	23-28