PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34322115-10	2021	In vivo, carvedilol alleviated inflammation in LL-37 mice, down-regulating TLR2, KLK5, and cathelicidin expression.	Carvedilol	9-19	kallikrein related-peptidase 5	Mus musculus	81-85
34322115-11	2021	In vitro, carvedilol decreased TLR2 expression in RAW 264.7 cells, further reducing KLK5 secretion and LL-37 expression and ultimately inhibiting rosacea-like inflammatory reactions.	Carvedilol	10-20	kallikrein related-peptidase 5	Mus musculus	84-88
23871720-4	2013	RESULTS: AzA directly inhibited KLK5 in cultured keratinocytes and gene expression of KLK5, Toll-like receptor-2, and cathelicidin in mouse skin.	azelaic acid	9-12	kallikrein related-peptidase 5	Mus musculus	32-36
23871720-4	2013	RESULTS: AzA directly inhibited KLK5 in cultured keratinocytes and gene expression of KLK5, Toll-like receptor-2, and cathelicidin in mouse skin.	azelaic acid	9-12	kallikrein related-peptidase 5	Mus musculus	86-90
22102857-6	2011	ES-2 clones overexpressing KLK5, 10/5, 10/6, 5/6 made significantly fewer colonies in soft agar.	Agar	91-95	kallikrein related-peptidase 5	Mus musculus	27-48
33744298-7	2021	Topical application of GSK951-containing cream inhibited KLK5 activity in TgKLK5 mouse skin, reduced trans-epidermal water loss and decreased pro-inflammatory cytokine expression.	gsk951	23-29	kallikrein related-peptidase 5	Mus musculus	57-61
32442469-8	2020	Joint invalidation of Klk5 and Camp significantly extended survival of Spink5-/-Klk5-/-Camp-/- mice.	Cyclic AMP	31-35	kallikrein related-peptidase 5	Mus musculus	80-84
32442469-8	2020	Joint invalidation of Klk5 and Camp significantly extended survival of Spink5-/-Klk5-/-Camp-/- mice.	Cyclic AMP	87-91	kallikrein related-peptidase 5	Mus musculus	22-26
32442469-8	2020	Joint invalidation of Klk5 and Camp significantly extended survival of Spink5-/-Klk5-/-Camp-/- mice.	Cyclic AMP	87-91	kallikrein related-peptidase 5	Mus musculus	80-84
29561728-3	2018	Further, we propose that KLK5 could be implicated in vaginal cancer development based on the fact that Klk5-/- mice are prone to develop vaginal tumors when exposed to 7,12-dimethylbenz[a]anthracene.	7,12-dimethylbenz[a	168-187	kallikrein related-peptidase 5	Mus musculus	25-29
29561728-3	2018	Further, we propose that KLK5 could be implicated in vaginal cancer development based on the fact that Klk5-/- mice are prone to develop vaginal tumors when exposed to 7,12-dimethylbenz[a]anthracene.	7,12-dimethylbenz[a	168-187	kallikrein related-peptidase 5	Mus musculus	103-107
29561728-3	2018	Further, we propose that KLK5 could be implicated in vaginal cancer development based on the fact that Klk5-/- mice are prone to develop vaginal tumors when exposed to 7,12-dimethylbenz[a]anthracene.	anthracene	188-198	kallikrein related-peptidase 5	Mus musculus	25-29
29561728-3	2018	Further, we propose that KLK5 could be implicated in vaginal cancer development based on the fact that Klk5-/- mice are prone to develop vaginal tumors when exposed to 7,12-dimethylbenz[a]anthracene.	anthracene	188-198	kallikrein related-peptidase 5	Mus musculus	103-107
27315464-4	2016	LL-37, KLK5, KLK7 and vitamin D receptor were induced by 1alpha, 25-dihydroxyvitamin D3 (VD3 ) and TLR-2 by Ad-CMV transfection in cultured NHEKs.	25-dihydroxyvitamin d3	65-87	kallikrein related-peptidase 5	Mus musculus	7-11
27551807-7	2016	In cultured wild type keratinocytes, both KALLIKREIN 5 and -7 colocalized with ceramide metabolites following calcium-induced differentiation.	Ceramides	79-87	kallikrein related-peptidase 5	Mus musculus	42-54
27551807-7	2016	In cultured wild type keratinocytes, both KALLIKREIN 5 and -7 colocalized with ceramide metabolites following calcium-induced differentiation.	Calcium	110-117	kallikrein related-peptidase 5	Mus musculus	42-54
21107351-5	2011	Overexpression of TLR2 on keratinocytes, treatment with TLR2 ligands, and analysis of TLR2-deficient mice resulted in a calcium-dependent release of kallikrein 5 from keratinocytes, a critical protease involved in the pathogenesis of rosacea.	Calcium	120-127	kallikrein related-peptidase 5	Mus musculus	149-161