PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2736535-0	1989	Endogenous retroviral env genes after N-methyl-N"-nitro-N-nitrosoguanidine treatment of mouse tumor cells: stable DNA amplification and rearrangement.	Methylnitronitrosoguanidine	38-74	melanoma antigen	Mus musculus	22-25
2477442-8	1989	Antisense oligonucleotides to endogenous MCF envelope gene (env) initiation regions caused: i) doubling or tripling of spleen cell RNA synthesis, and ii) marked increases in lymphocyte surface Ia and Ig expression relative to control oligonucleotides.	Oligonucleotides	10-26	melanoma antigen	Mus musculus	45-48
2477442-8	1989	Antisense oligonucleotides to endogenous MCF envelope gene (env) initiation regions caused: i) doubling or tripling of spleen cell RNA synthesis, and ii) marked increases in lymphocyte surface Ia and Ig expression relative to control oligonucleotides.	Oligonucleotides	234-250	melanoma antigen	Mus musculus	45-48
2736535-1	1989	Immunogenic tumor variant clones derived by N-methyl-N"-nitro-N-nitrosoguanidine treatment of Eb lymphoma cells showed structurally altered gp70 env proteins at the cell surface.	Methylnitronitrosoguanidine	44-80	melanoma antigen	Mus musculus	145-148
3019002-3	1986	This effect appears specific for the Pr65gag polyprotein, since the env precursor polyprotein Pr80env was normally synthesized and remained undegraded in cerulenin-treated 3JE-infected cells.	Cerulenin	154-163	melanoma antigen	Mus musculus	68-71
3196170-0	1988	Biological and molecular analysis of LCV, an endogenous retrovirus with defective env gene.	lcv	37-40	melanoma antigen	Mus musculus	82-85
2416245-7	1985	Sulphated GAG, with CS being the predominant component, was localized for the most part on the oral-side mesenchyme both in the anterior and posterior palate.	Cesium	20-22	melanoma antigen	Mus musculus	10-13
3016982-9	1986	RNase T1-resistant oligonucleotide analysis of a polytropic MuLV from a 26-day-old mouse indicated that its entire env gene was derived from nonecotropic sequences while the remainder of its genome was indistinguishable from the ecotropic parent.	Oligonucleotides	19-34	melanoma antigen	Mus musculus	115-118
2873806-11	1986	Treatment of mice with phenylhydrazine which greatly stimulates erythroid differentiation in spleens increased the level of SFFV/MCF related env RNAs only in the spleens, suggesting a possible correlation between the SFFV/MCF env transcription and the stimulation of the erythroid spleen cells.	phenylhydrazine	23-38	melanoma antigen	Mus musculus	141-144
2873806-11	1986	Treatment of mice with phenylhydrazine which greatly stimulates erythroid differentiation in spleens increased the level of SFFV/MCF related env RNAs only in the spleens, suggesting a possible correlation between the SFFV/MCF env transcription and the stimulation of the erythroid spleen cells.	phenylhydrazine	23-38	melanoma antigen	Mus musculus	226-229
6333515-10	1984	The data for R- and M-p10"s shows that they are cleavage products of the gag precursor with the structure p10-Thr-Leu-Asp-Asp-OH.	Threonine	110-113	melanoma antigen	Mus musculus	73-76
6333515-10	1984	The data for R- and M-p10"s shows that they are cleavage products of the gag precursor with the structure p10-Thr-Leu-Asp-Asp-OH.	Leucine	114-117	melanoma antigen	Mus musculus	73-76
6333515-10	1984	The data for R- and M-p10"s shows that they are cleavage products of the gag precursor with the structure p10-Thr-Leu-Asp-Asp-OH.	Aspartic Acid	118-121	melanoma antigen	Mus musculus	73-76
6333515-10	1984	The data for R- and M-p10"s shows that they are cleavage products of the gag precursor with the structure p10-Thr-Leu-Asp-Asp-OH.	Aspartic Acid	122-125	melanoma antigen	Mus musculus	73-76
6330991-7	1984	Decreased incorporation of both env and gag proteins into extracellular virions was observed, despite the fact that the gag proteins were processed normally intracellularly; in contrast, DNM treatment of Gazdar murine sarcoma virus-infected HTG2 cells, which produce only gag but not env proteins, did not inhibit the release of extracellular virus.	1-DEOXYNOJIRIMYCIN	187-190	melanoma antigen	Mus musculus	284-287
6330991-9	1984	These studies indicate that the normal maturation process involved in the formation of complex oligosaccharides is necessary to obtain efficient transport to the plasma membrane and proteolysis of PrEnv, and also provide evidence suggesting a role for the env proteins in regulating assembly of gag proteins into virions.	Oligosaccharides	95-111	melanoma antigen	Mus musculus	256-259
6198451-7	1984	The absence of fluorescent stain in L929 cells further supported these results and suggested that LCV and the L929 parental cell line lack the uncleaved precursor and the final product of the env gene translation process.	leucogentian violet	98-101	melanoma antigen	Mus musculus	192-195
6252348-7	1980	Upon cross-linking with methyl 4-mercaptobutyrimidate hydrochloride a small amount of what seems to be a heterodimer made up of the N-terminal gag protein p10 and the hydrophobic membrane glycoprotein gp36 can be observed.	methyl 4-mercaptobutyrimidate	24-67	melanoma antigen	Mus musculus	143-146
6302990-11	1983	The P100 gag-mos polyproteins are made in amounts that are easily detected by radiolabeling experiments using [3H]leucine.	3h]leucine	111-121	melanoma antigen	Mus musculus	9-12
6184623-8	1982	Besides, dexamethasone switches on the env (but not the gag) product precursor processing, however, expression of the mature envelope protein on the cellular membranes occurred only in cells, entering the insulin-induced type of differentiation, as it was shown by RIP test with iodinated cells and MIF test.	Dexamethasone	9-22	melanoma antigen	Mus musculus	39-42
6281471-3	1982	All of these unique oligonucleotides were located in the env gene region and were probably responsible for the host range differences between these viruses, as well as the lymphomagenic and paralytogenic properties of the viruses.	Oligonucleotides	20-36	melanoma antigen	Mus musculus	57-60
197262-4	1977	and, on the basis of analogy to the known sequence of a prototype type C virus of mouse origin, the map order of the gag region of the feline type C viral genome has been tentatively deduced as NH2-p15-p12-p10-COOH.	Carbonic Acid	210-214	melanoma antigen	Mus musculus	117-120
219210-0	1979	Tryptic peptide analysis of gag gene proteins of endogenous mouse type C viruses.	Peptides	8-15	melanoma antigen	Mus musculus	28-31
7400758-4	1980	In the present report we show that the HRS/J polytropic viruses are env gene recombinants with unique oligonucleotide and peptide maps.	Oligonucleotides	102-117	melanoma antigen	Mus musculus	68-71
7365878-4	1980	It was found that the electrophoretic mobility of the major gag-related cell-free product of both Rauscher murine leukemia virus (R-MuLV) and Moloney murine sarcoma virus 124 (Mo-MuSV-124) RNA was dependent on the concentration of canavanine used during translation.	Canavanine	231-241	melanoma antigen	Mus musculus	60-63
7365878-5	1980	As the canavanine concentration was increased up to 4 mM, the apparent size of the major gag-related polypeptide also increased from 65,000 (R-MuLV RNA) or 63,000 (Mo-MuSV-124 RNA) to approximately 80,000 daltons.	Canavanine	7-17	melanoma antigen	Mus musculus	89-92
6245238-3	1980	A correspondence between the sequence of some of these oligonucleotides and the amino acid sequence of some virus-coded gag gene proteins is reported.	Oligonucleotides	55-71	melanoma antigen	Mus musculus	120-123
230729-5	1979	PGE1-induced stimulation of cAMP levels is dose-dependently linked to an increase in biosynthetic activity of the cells, visible in increased GAG biosynthesis and PG formation.	Alprostadil	0-4	melanoma antigen	Mus musculus	142-145
230729-5	1979	PGE1-induced stimulation of cAMP levels is dose-dependently linked to an increase in biosynthetic activity of the cells, visible in increased GAG biosynthesis and PG formation.	Cyclic AMP	28-32	melanoma antigen	Mus musculus	142-145
230729-5	1979	PGE1-induced stimulation of cAMP levels is dose-dependently linked to an increase in biosynthetic activity of the cells, visible in increased GAG biosynthesis and PG formation.	Prostaglandins	0-2	melanoma antigen	Mus musculus	142-145
230729-6	1979	cAMP-dependent enhancement of GAG biosynthesis does not alter the carbohydrate spectrum of the secreted GAG, indicating that only the amount, but not the quality of the secreted GAG is affected by PGE1 or cAMP.	Cyclic AMP	0-4	melanoma antigen	Mus musculus	30-33
230729-12	1979	These effects on cAMP levels are also reflected in GAG biosynthesis and proliferative activity of the cells.	Cyclic AMP	17-21	melanoma antigen	Mus musculus	51-54
31607605-3	2019	We recently tested the efficacy of a Virus Like Particle (VLP) vaccine for Zika virus in mice and found that Capsid-preMembrane-Env (CprME) VLPs generated a better neutralizing antibody response than preMembrane-Env (prME) VLPs.	premembrane	116-127	melanoma antigen	Mus musculus	128-131
32871749-3	2020	MATERIALS AND METHODS: Male and female FVB/N mice were treated with the reverse transcriptase inhibitor Lamivudine for seven consecutive weeks.	Lamivudine	104-114	melanoma antigen	Mus musculus	72-93
32802564-4	2020	Results showed that rich phenolic and flavonoid content of MELA had moderate dose dependent free radical scavenging activity (IC50: 62.0 mug/mL for DPPH  and 6.0 mug/mL for ABTS +).	Flavonoids	38-47	melanoma antigen	Mus musculus	59-63
32802564-4	2020	Results showed that rich phenolic and flavonoid content of MELA had moderate dose dependent free radical scavenging activity (IC50: 62.0 mug/mL for DPPH  and 6.0 mug/mL for ABTS +).	1,1-diphenyl-2-picrylhydrazyl	148-152	melanoma antigen	Mus musculus	59-63
32802564-4	2020	Results showed that rich phenolic and flavonoid content of MELA had moderate dose dependent free radical scavenging activity (IC50: 62.0 mug/mL for DPPH  and 6.0 mug/mL for ABTS +).	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	173-177	melanoma antigen	Mus musculus	59-63
66219-4	1977	An evaluation of the specific antiviral agents dimethylbenzyldemethl-rifampicin and streptovaricin-comples, which inhibit the enzyme reverse transcriptase, revealed no depay in the induction of bladder tumors by the chemical carcinogen, 2-formylamino-4-(5-nitro-2-furyl) thiazole (FANFT) in C3H mice.	dimethylbenzyldemethl-rifampicin	47-79	melanoma antigen	Mus musculus	133-154
66219-4	1977	An evaluation of the specific antiviral agents dimethylbenzyldemethl-rifampicin and streptovaricin-comples, which inhibit the enzyme reverse transcriptase, revealed no depay in the induction of bladder tumors by the chemical carcinogen, 2-formylamino-4-(5-nitro-2-furyl) thiazole (FANFT) in C3H mice.	Streptovaricin	84-98	melanoma antigen	Mus musculus	133-154
33218286-5	2020	As expected for monotherapy, viral loads rebounded after about a week and different viral escape pathways were observed, involving the deletion of glycans in the envelope glycoprotein at positions 130 or 160.	Polysaccharides	147-154	melanoma antigen	Mus musculus	162-183
31569763-4	2019	Mice previously vaccinated against Tetanus raised stronger humoral immune responses against Env after immunization with Env-CaP-p30 than mice not vaccinated against Tetanus.	calcium phosphate	124-127	melanoma antigen	Mus musculus	92-95
31569763-4	2019	Mice previously vaccinated against Tetanus raised stronger humoral immune responses against Env after immunization with Env-CaP-p30 than mice not vaccinated against Tetanus.	calcium phosphate	124-127	melanoma antigen	Mus musculus	120-123
30355687-1	2019	Glycosylated Gag (glycoGag) is an accessory protein expressed by most gammaretroviruses, including murine leukemia virus (MLV).	glycogag	18-26	melanoma antigen	Mus musculus	13-16
30781796-4	2019	Here, our results indicate the glycan moiety of Env as the responsible immune modulating activity.	Polysaccharides	31-37	melanoma antigen	Mus musculus	48-51
30781796-8	2019	Accordingly, the stretch of oligomannose glycans in the C2V3 domain of Env might mediate a specific uptake and/or signaling modus in antigen presenting cells by involving interaction with an as yet unknown C-type lectin receptor.	oligomannose glycans	28-48	melanoma antigen	Mus musculus	71-74
29978510-0	2018	Anti-inflammatory effects of the GAG-binding CXCL9(74-103) peptide in dinitrofluorobenzene-induced contact hypersensitivity in mice.	Dinitrofluorobenzene	70-90	melanoma antigen	Mus musculus	33-36
29978510-5	2018	In addition to modified chemokines, a GAG-binding peptide consisting of the 30 COOH-terminal residues of CXCL9, that is CXCL9(74-103), inhibited CXCL8- and monosodium urate crystal-induced neutrophil migration.	Uric Acid	156-172	melanoma antigen	Mus musculus	38-41
29978510-6	2018	OBJECTIVE: We wanted to explore whether interference with chemokine-GAG interactions by CXCL9(74-103) reduces inflammation in neutrophil-dependent dinitrofluorobenzene-induced contact hypersensitivity.	Dinitrofluorobenzene	147-167	melanoma antigen	Mus musculus	68-71
29205929-5	2018	First strong gag specific helper CD4+ T cells are induced in mice by selected targeting of anti-DEC205-gagP24 protein vaccine to dendritic cells (DC) in situ together with polyICLC as adjuvant.	poly ICLC	172-180	melanoma antigen	Mus musculus	13-16
29281818-4	2017	Env immunization of CD4bs bnAb heavy chain rearrangement (VHDJH) knockin mice similarly induced V1V2-glycan neutralizing antibodies (nAbs), wherein the human CD4bs VH chains were replaced with mouse rearrangements bearing diversity region (D)-D fusions, creating antibodies with long, tyrosine-rich HCDR3s.	Polysaccharides	101-107	melanoma antigen	Mus musculus	0-3
29575932-5	2018	The results showed that hydrogels could maintain shapes for more than 16 days and the release rate of BSA in PF/GAG composite gels was much slower than in PF127 gels, due to the affinity between BSA and GAG.	pyrazofurin	109-111	melanoma antigen	Mus musculus	112-115
29575932-5	2018	The results showed that hydrogels could maintain shapes for more than 16 days and the release rate of BSA in PF/GAG composite gels was much slower than in PF127 gels, due to the affinity between BSA and GAG.	pyrazofurin	109-111	melanoma antigen	Mus musculus	203-206
29575932-8	2018	In vivo anti-inflammation results showed that PF/GAG@BMP-2 composite hydrogels had the most efficient efficacy on recovery of injured cartilage, which is induced by osteoarthritis, compared to the control groups (PF127@BMP-2 or BMP-2 saline solution).	pf127	213-218	melanoma antigen	Mus musculus	46-52
29281818-4	2017	Env immunization of CD4bs bnAb heavy chain rearrangement (VHDJH) knockin mice similarly induced V1V2-glycan neutralizing antibodies (nAbs), wherein the human CD4bs VH chains were replaced with mouse rearrangements bearing diversity region (D)-D fusions, creating antibodies with long, tyrosine-rich HCDR3s.	Tyrosine	285-293	melanoma antigen	Mus musculus	0-3
29230223-4	2017	We detected lower Env-specific binding antibody titers and increased skewing toward Th2 responses in mice immunized with GLA-fixed trimers compared to mice immunized with unfixed trimers, as shown by a higher Env-specific IgG1:IgG2b antibody subclass ratio.	Glutaral	121-124	melanoma antigen	Mus musculus	18-21
29230223-4	2017	We detected lower Env-specific binding antibody titers and increased skewing toward Th2 responses in mice immunized with GLA-fixed trimers compared to mice immunized with unfixed trimers, as shown by a higher Env-specific IgG1:IgG2b antibody subclass ratio.	Glutaral	121-124	melanoma antigen	Mus musculus	209-212
27898729-2	2016	The GAG family includes sulfated heparin, heparan sulfate (HS), dermatan sulfate (DS), chondroitin sulfate (CS), keratan sulfate, and non-sulfated hyaluronan.	Dermatan Sulfate	64-80	melanoma antigen	Mus musculus	4-7
28851629-4	2017	Additionally, Gag-specific TNF-alpha secreting CD8+ and CD4+ T cells and Env-specific IL-2 secreting T cells were also elicited by mice immunized with Gag and Env constructs, respectively, as estimated by intracellular cytokine staining assay.	Glycosaminoglycans	14-17	melanoma antigen	Mus musculus	159-162
27898729-2	2016	The GAG family includes sulfated heparin, heparan sulfate (HS), dermatan sulfate (DS), chondroitin sulfate (CS), keratan sulfate, and non-sulfated hyaluronan.	Heparitin Sulfate	42-57	melanoma antigen	Mus musculus	4-7
28592540-7	2017	Following immunization of mice, serologic analysis demonstrated that the covalently coupled trimers elicited Env-directed antibodies in a manner statistically significantly improved compared to soluble trimers and nickel-conjugated trimers.	Nickel	214-220	melanoma antigen	Mus musculus	109-112
27898729-2	2016	The GAG family includes sulfated heparin, heparan sulfate (HS), dermatan sulfate (DS), chondroitin sulfate (CS), keratan sulfate, and non-sulfated hyaluronan.	Heparitin Sulfate	59-61	melanoma antigen	Mus musculus	4-7
27898729-2	2016	The GAG family includes sulfated heparin, heparan sulfate (HS), dermatan sulfate (DS), chondroitin sulfate (CS), keratan sulfate, and non-sulfated hyaluronan.	Dermatan Sulfate	82-84	melanoma antigen	Mus musculus	4-7
27898729-2	2016	The GAG family includes sulfated heparin, heparan sulfate (HS), dermatan sulfate (DS), chondroitin sulfate (CS), keratan sulfate, and non-sulfated hyaluronan.	Chondroitin Sulfates	87-106	melanoma antigen	Mus musculus	4-7
27898729-2	2016	The GAG family includes sulfated heparin, heparan sulfate (HS), dermatan sulfate (DS), chondroitin sulfate (CS), keratan sulfate, and non-sulfated hyaluronan.	Chondroitin Sulfates	108-110	melanoma antigen	Mus musculus	4-7
27898729-2	2016	The GAG family includes sulfated heparin, heparan sulfate (HS), dermatan sulfate (DS), chondroitin sulfate (CS), keratan sulfate, and non-sulfated hyaluronan.	Keratan Sulfate	113-128	melanoma antigen	Mus musculus	4-7
27898729-2	2016	The GAG family includes sulfated heparin, heparan sulfate (HS), dermatan sulfate (DS), chondroitin sulfate (CS), keratan sulfate, and non-sulfated hyaluronan.	Hyaluronic Acid	147-157	melanoma antigen	Mus musculus	4-7
27898729-3	2016	Because relative expression of GAGs is dependent on cell-type and niche, isolating GAGs from cell cultures and tissues may provide insight into cell- and tissue-specific GAG structure and functions.	Glycosaminoglycans	83-87	melanoma antigen	Mus musculus	31-34
27898729-7	2016	We found that these GAG extracts were heavily contaminated with RNA, which co-migrated with HS in barium acetate gel electrophoresis and interfered with 1,9-dimethylmethylene blue (DMMB) assays, resulting in an overestimation of GAG yields.	Heparitin Sulfate	92-94	melanoma antigen	Mus musculus	20-23
27898729-7	2016	We found that these GAG extracts were heavily contaminated with RNA, which co-migrated with HS in barium acetate gel electrophoresis and interfered with 1,9-dimethylmethylene blue (DMMB) assays, resulting in an overestimation of GAG yields.	Barium acetate	98-112	melanoma antigen	Mus musculus	20-23
27898729-7	2016	We found that these GAG extracts were heavily contaminated with RNA, which co-migrated with HS in barium acetate gel electrophoresis and interfered with 1,9-dimethylmethylene blue (DMMB) assays, resulting in an overestimation of GAG yields.	1,9-dimethylmethylene blue	153-179	melanoma antigen	Mus musculus	20-23
27898729-7	2016	We found that these GAG extracts were heavily contaminated with RNA, which co-migrated with HS in barium acetate gel electrophoresis and interfered with 1,9-dimethylmethylene blue (DMMB) assays, resulting in an overestimation of GAG yields.	1,9-dimethylmethylene blue	181-185	melanoma antigen	Mus musculus	20-23
27898729-7	2016	We found that these GAG extracts were heavily contaminated with RNA, which co-migrated with HS in barium acetate gel electrophoresis and interfered with 1,9-dimethylmethylene blue (DMMB) assays, resulting in an overestimation of GAG yields.	1,9-dimethylmethylene blue	181-185	melanoma antigen	Mus musculus	229-232
27898729-9	2016	GAG extracts from all examined cell lines and tissues contained varying amounts of contaminating RNA, which interfered with GAG quantification using DMMB assays and characterization of GAGs by barium acetate gel electrophoresis.	1,9-dimethylmethylene blue	149-153	melanoma antigen	Mus musculus	0-3
27898729-9	2016	GAG extracts from all examined cell lines and tissues contained varying amounts of contaminating RNA, which interfered with GAG quantification using DMMB assays and characterization of GAGs by barium acetate gel electrophoresis.	Glycosaminoglycans	185-189	melanoma antigen	Mus musculus	0-3
27898729-9	2016	GAG extracts from all examined cell lines and tissues contained varying amounts of contaminating RNA, which interfered with GAG quantification using DMMB assays and characterization of GAGs by barium acetate gel electrophoresis.	Barium acetate	193-207	melanoma antigen	Mus musculus	0-3
27609573-3	2016	The recombinant plasmid pcDNA4/myc-His/exJSRV- env was transiently transfected into NIH3T3 cells by Lipofectamine(TM) LTX.	Lipofectamine	100-113	melanoma antigen	Mus musculus	47-50
27609573-3	2016	The recombinant plasmid pcDNA4/myc-His/exJSRV- env was transiently transfected into NIH3T3 cells by Lipofectamine(TM) LTX.	Thulium	114-116	melanoma antigen	Mus musculus	47-50
27021123-3	2016	In this work, we have developed such a new probe, Mela-TYR, which bears morpholine as a melanosome-targeting group and 4-aminophenol as a tyrosinase reaction group.	Tyrosine	55-58	melanoma antigen	Mus musculus	50-54
27155499-8	2016	Consequently, the production of HA-NA containing VLPs using Gag as scaffold was evaluated in a 3-L controlled stirred tank bioreactor.	ha-na	32-37	melanoma antigen	Mus musculus	60-63
27021123-3	2016	In this work, we have developed such a new probe, Mela-TYR, which bears morpholine as a melanosome-targeting group and 4-aminophenol as a tyrosinase reaction group.	morpholine	72-82	melanoma antigen	Mus musculus	50-54
27021123-3	2016	In this work, we have developed such a new probe, Mela-TYR, which bears morpholine as a melanosome-targeting group and 4-aminophenol as a tyrosinase reaction group.	4-aminophenol	119-132	melanoma antigen	Mus musculus	50-54
27928916-6	2016	It contained enhanced green fluorescent protein (EGFP) in the proline rich region (PRR) of Env.	Proline	62-69	melanoma antigen	Mus musculus	91-94
26828792-3	2016	Their structural data through LC/MS, GC/MS and NMR analysis revealed that MEL-A with two acetyls was the major compound and the identified homologs of MEL-A contained a length of C8 to C14 fatty acid chains.	Cysteine	89-96	melanoma antigen	Mus musculus	74-79
26828792-3	2016	Their structural data through LC/MS, GC/MS and NMR analysis revealed that MEL-A with two acetyls was the major compound and the identified homologs of MEL-A contained a length of C8 to C14 fatty acid chains.	Fatty Acids	189-199	melanoma antigen	Mus musculus	151-156
26303011-5	2015	METHODS: We have engineered increased GAG-binding affinity into human CXCL8, thereby obtaining a competitive inhibitor that displaces wild-type IL-8/CXCL8 from GAGs.	Glycosaminoglycans	160-164	melanoma antigen	Mus musculus	38-41
25020048-4	2014	To apply this system to the delivery of HIV antigens, Env gp140 trimers with terminal his-tags (gp140T-his) were anchored to the surface of lipid nanocapsules via Ni-NTA-functionalized lipids.	ni-nta	163-169	melanoma antigen	Mus musculus	54-57
26416733-1	2015	HIV-1 Nef and the unrelated mouse leukaemia virus glycosylated Gag (glycoGag) strongly enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent manner.	glycogag	68-76	melanoma antigen	Mus musculus	63-66
26246566-9	2015	These data inform immunogen design and suggest that it is useful to obscure nonneutralizing epitopes presented on the base of soluble Env trimers and that the glycan shield of well-formed HIV Env trimers is virtually impenetrable for murine B cell receptors (BCRs).	Polysaccharides	159-165	melanoma antigen	Mus musculus	192-195
25020048-4	2014	To apply this system to the delivery of HIV antigens, Env gp140 trimers with terminal his-tags (gp140T-his) were anchored to the surface of lipid nanocapsules via Ni-NTA-functionalized lipids.	Histidine	10-13	melanoma antigen	Mus musculus	54-57
25020048-4	2014	To apply this system to the delivery of HIV antigens, Env gp140 trimers with terminal his-tags (gp140T-his) were anchored to the surface of lipid nanocapsules via Ni-NTA-functionalized lipids.	Histidine	86-89	melanoma antigen	Mus musculus	54-57
23734945-3	2013	We have demonstrated that EXTL2 terminates chain elongation of GAGs (glycosaminoglycans), and thereby regulates GAG biosynthesis.	Glycosaminoglycans	69-87	melanoma antigen	Mus musculus	63-66
25121610-7	2014	The administration of the ENV TMD in vivo to lipotechoic acid (LTA)/Galactosamine-mediated septic mice resulted in a significant decrease in mortality and in tissue damage, due to the weakening of systemic macrophage activation.	lipotechoic acid	45-61	melanoma antigen	Mus musculus	26-29
25121610-7	2014	The administration of the ENV TMD in vivo to lipotechoic acid (LTA)/Galactosamine-mediated septic mice resulted in a significant decrease in mortality and in tissue damage, due to the weakening of systemic macrophage activation.	lta	63-66	melanoma antigen	Mus musculus	26-29
25121610-7	2014	The administration of the ENV TMD in vivo to lipotechoic acid (LTA)/Galactosamine-mediated septic mice resulted in a significant decrease in mortality and in tissue damage, due to the weakening of systemic macrophage activation.	Galactosamine	68-81	melanoma antigen	Mus musculus	26-29
24156704-4	2013	Env-specific antibody levels after the VLP booster immunizations were significantly higher in GagPol-immunized mice than in mock-vaccinated controls.	gagpol	94-100	melanoma antigen	Mus musculus	0-3
24156704-5	2013	Adoptive transfer of CD4+ T cells from GagPol-immunized mice also enhanced the Env antibody response to VLP immunization in the recipient mice.	gagpol	39-45	melanoma antigen	Mus musculus	79-82
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	melanoma antigen	Mus musculus	40-44
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Dinoprostone	398-414	melanoma antigen	Mus musculus	40-44
23983093-4	2014	In addition, topical application with MEFA or MELA effectively attenuated tumor incidence, multiplicity, volume, malignancy as well as angiogenesis of TPA-stimulated skin tumor promotion in DMBA-initiated mice.	Tetradecanoylphorbol Acetate	151-154	melanoma antigen	Mus musculus	46-50
23983093-4	2014	In addition, topical application with MEFA or MELA effectively attenuated tumor incidence, multiplicity, volume, malignancy as well as angiogenesis of TPA-stimulated skin tumor promotion in DMBA-initiated mice.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	190-194	melanoma antigen	Mus musculus	46-50
24073803-10	2013	Furthermore, addition of pTat not only induced a more balanced Th1 and Th2 response, but also broadened IgG subclass responses to antigens Gag and Pol.	ptat	25-29	melanoma antigen	Mus musculus	139-142
23698308-0	2013	Unique N-linked glycosylation of CasBrE Env influences its stability, processing, and viral infectivity but not its neurotoxicity.	Nitrogen	7-8	melanoma antigen	Mus musculus	40-43
23698308-0	2013	Unique N-linked glycosylation of CasBrE Env influences its stability, processing, and viral infectivity but not its neurotoxicity.	casbre	33-39	melanoma antigen	Mus musculus	40-43
23698308-11	2013	Thus, while unique N-glycosylation affected structural features of Env involved in protein stability, proteolytic processing, and virus assembly and entry, these changes had minimal impact on CasBrE Env neurotoxicity.	Nitrogen	19-20	melanoma antigen	Mus musculus	67-70
22686371-4	2012	MIP-2 GAG-binding residues were identified that interact with heparin disaccharide I-S by NMR spectroscopy.	HEPARIN DISACCHARIDE I-S	62-86	melanoma antigen	Mus musculus	6-9
23671100-7	2013	Strikingly, glyco-Gag mutant virus reverted to glyco-Gag-containing virus only in WT and not APOBEC3 KO mice, indicating that counteracting APOBEC3 is the major function of glyco-Gag.	glyco	12-17	melanoma antigen	Mus musculus	18-21
23671100-7	2013	Strikingly, glyco-Gag mutant virus reverted to glyco-Gag-containing virus only in WT and not APOBEC3 KO mice, indicating that counteracting APOBEC3 is the major function of glyco-Gag.	glyco	12-17	melanoma antigen	Mus musculus	53-56
23671100-7	2013	Strikingly, glyco-Gag mutant virus reverted to glyco-Gag-containing virus only in WT and not APOBEC3 KO mice, indicating that counteracting APOBEC3 is the major function of glyco-Gag.	glyco	12-17	melanoma antigen	Mus musculus	53-56
23011030-5	2013	We demonstrate that subcutaneous immunization of mice with mRNA encoding the HIV-1 antigen Gag complexed with DOTAP/DOPE elicits antigen-specific, functional T cell responses resulting in specific killing of Gag peptide-pulsed cells and the induction of humoral responses.	1,2-dioleoyloxy-3-(trimethylammonium)propane	110-115	melanoma antigen	Mus musculus	91-94
23011030-5	2013	We demonstrate that subcutaneous immunization of mice with mRNA encoding the HIV-1 antigen Gag complexed with DOTAP/DOPE elicits antigen-specific, functional T cell responses resulting in specific killing of Gag peptide-pulsed cells and the induction of humoral responses.	1,2-dioleoyloxy-3-(trimethylammonium)propane	110-115	melanoma antigen	Mus musculus	208-211
23011030-5	2013	We demonstrate that subcutaneous immunization of mice with mRNA encoding the HIV-1 antigen Gag complexed with DOTAP/DOPE elicits antigen-specific, functional T cell responses resulting in specific killing of Gag peptide-pulsed cells and the induction of humoral responses.	dioleoyl phosphatidylethanolamine	116-120	melanoma antigen	Mus musculus	91-94
23011030-5	2013	We demonstrate that subcutaneous immunization of mice with mRNA encoding the HIV-1 antigen Gag complexed with DOTAP/DOPE elicits antigen-specific, functional T cell responses resulting in specific killing of Gag peptide-pulsed cells and the induction of humoral responses.	dioleoyl phosphatidylethanolamine	116-120	melanoma antigen	Mus musculus	208-211
21482433-2	2011	We recently developed particle clusters coated with hyaluronan (termed gagomers; GAG), and showed that they can deliver the insoluble drug paclitaxel directly into CD44-over-expressing tumors in a mouse tumor model.	Hyaluronic Acid	52-62	melanoma antigen	Mus musculus	81-84
22509350-6	2012	Co-administering Env with Gag or GPN derivatives largely abrogated Gag-specific responses.	GPDA	33-36	melanoma antigen	Mus musculus	67-70
22479338-8	2012	The differing Gag-specific T-cell phenotype elicited by the prime-boost regimens may be related to the reduced inflammation observed with the pantothenate auxotroph strain compared to the parent strain.	Pantothenic Acid	142-154	melanoma antigen	Mus musculus	14-17
21649527-7	2011	Differences in immune, cornified envelope protein, muscle, and erythrocyte genes were found in CS-exposed lung.	Cesium	95-97	melanoma antigen	Mus musculus	33-49
21482433-2	2011	We recently developed particle clusters coated with hyaluronan (termed gagomers; GAG), and showed that they can deliver the insoluble drug paclitaxel directly into CD44-over-expressing tumors in a mouse tumor model.	Paclitaxel	139-149	melanoma antigen	Mus musculus	81-84
20483925-0	2010	CCR1- and CCR5-mediated inactivation of leukocytes by a nonglycosaminoglycan (non-GAG)-binding variant of n-nonanoyl-CCL14 (NNY-CCL14).	n-nonanoyl-ccl14	106-122	melanoma antigen	Mus musculus	82-85
20668230-6	2010	When mAb heavy chain was engineered to express HIV Gag p24, the fusion mAb induced interferon-gamma- and interleukin-2-producing CD4(+) T cells in hDEC205 transgenic mice, if polynocinic polycytidylic acid was coadministered as an adjuvant.	Poly C	187-205	melanoma antigen	Mus musculus	51-54
20483925-0	2010	CCR1- and CCR5-mediated inactivation of leukocytes by a nonglycosaminoglycan (non-GAG)-binding variant of n-nonanoyl-CCL14 (NNY-CCL14).	nny-ccl14	124-133	melanoma antigen	Mus musculus	82-85
20483925-4	2010	In this study, a non-GAG-binding variant of NNY-CCL14 was generated by mutating basic amino acids within the identified GAG-binding 49BBXB52 motif.	Amino Acids, Basic	80-97	melanoma antigen	Mus musculus	21-24
20483925-4	2010	In this study, a non-GAG-binding variant of NNY-CCL14 was generated by mutating basic amino acids within the identified GAG-binding 49BBXB52 motif.	Amino Acids, Basic	80-97	melanoma antigen	Mus musculus	120-123
19058849-3	2009	Here, we show that the transduction of the env-gene (gp70) of Friend murine leukemia virus (F-MuLV) sensitized C3H-derived myeloid leukemia cells to DNA-damage (ionizing radiation as well as doxorubicin)-induced apoptosis through the activation of DNA-dependent protein kinase (DNA-PK) and P53.	Doxorubicin	191-202	melanoma antigen	Mus musculus	43-46
19619587-1	2009	DYT1 dystonia is caused by a trinucleotide deletion of GAG (DeltaGAG) in DYT1, which codes for torsinA.	trinucleotide	29-42	melanoma antigen	Mus musculus	55-58
20064650-3	2010	Affinity to GAG has been evaluated by sorption on heparin-Sepharose.	Heparin	50-57	melanoma antigen	Mus musculus	12-15
20064650-3	2010	Affinity to GAG has been evaluated by sorption on heparin-Sepharose.	Sepharose	58-67	melanoma antigen	Mus musculus	12-15
16938851-2	2006	The major GAG in cornea is keratan sulfate (KS), which is N-linked to one of three PG core proteins.	Keratan Sulfate	27-42	melanoma antigen	Mus musculus	10-13
18800055-1	2008	The activity of the membrane fusion protein Env of Moloney mouse leukaemia virus is controlled by isomerization of the disulphide that couples its transmembrane (TM) and surface (SU) subunits.	disulphide	119-129	melanoma antigen	Mus musculus	44-47
18800055-2	2008	We have arrested Env activation at a stage prior to isomerization by alkylating the active thiol in SU and compared the structure of isomerization-arrested Env with that of native Env.	Sulfhydryl Compounds	91-96	melanoma antigen	Mus musculus	17-20
18800055-2	2008	We have arrested Env activation at a stage prior to isomerization by alkylating the active thiol in SU and compared the structure of isomerization-arrested Env with that of native Env.	su	100-102	melanoma antigen	Mus musculus	17-20
18657584-7	2008	However, the co-administration of pmGM-CSF with pmIL-12 did significantly enhance env-specific proliferative responses and vaccine efficacy in the murine vaccinia virus challenge model relative to mice immunized with the env pDNA vaccine adjuvanted with either pmGM-CSF or pmIL-12 alone.	pmil-12	48-55	melanoma antigen	Mus musculus	82-85
18184703-0	2008	Importance of conserved cysteine residues in the coronavirus envelope protein.	Cysteine	24-32	melanoma antigen	Mus musculus	61-77
19070345-5	2009	Our analysis revealed that the immunoreceptor tyrosine-based activation motif (ITAM) of LMP-2A is important for HERV-K18 env transactivation.	Tyrosine	46-54	melanoma antigen	Mus musculus	121-124
19070345-7	2009	However, in our study, single-tyrosine mutants of ITAM still retained full induction of HERV-K18 env.	Tyrosine	30-38	melanoma antigen	Mus musculus	97-100
18272752-6	2008	Nucleotide sequencing of WN25A viruses recovered from the brains of B-cell-deficient mice revealed that the conserved N-linked glycosylation site in the viral envelope protein was abolished by substitution of a serine residue at position 155.	Nitrogen	0-1	melanoma antigen	Mus musculus	159-175
18272752-6	2008	Nucleotide sequencing of WN25A viruses recovered from the brains of B-cell-deficient mice revealed that the conserved N-linked glycosylation site in the viral envelope protein was abolished by substitution of a serine residue at position 155.	Serine	211-217	melanoma antigen	Mus musculus	159-175
18250460-6	2008	Mice primed with a single administration of rLm-gag by any route and then boosted with rAd5-gag intramuscularly exhibited abundant Gag-specific CD8 T cells in spleen and vaginal lamina propria.	Glycosaminoglycans	131-134	melanoma antigen	Mus musculus	48-51
18250460-6	2008	Mice primed with a single administration of rLm-gag by any route and then boosted with rAd5-gag intramuscularly exhibited abundant Gag-specific CD8 T cells in spleen and vaginal lamina propria.	Glycosaminoglycans	131-134	melanoma antigen	Mus musculus	92-95
16938851-2	2006	The major GAG in cornea is keratan sulfate (KS), which is N-linked to one of three PG core proteins.	Keratan Sulfate	44-46	melanoma antigen	Mus musculus	10-13
16938851-9	2006	The enzymatic sulfation of KS GAG chains is thus identified as a key requirement for PG biosynthesis and collagen matrix organization.	Keratan Sulfate	27-29	melanoma antigen	Mus musculus	30-33
16707790-3	2006	Necdin binds to its homologous MAGE protein MAGE-D1 (also known as NRAGE or Dlxin-1), which interacts with Msx (msh homeobox) and Dlx (distal-less homeobox) family homeodomain transcription factors.	msx	107-110	melanoma antigen	Mus musculus	31-35
16338794-7	2005	This is consistent with the quantitative measurement of glycosaminoglycans, whereby a significant increase in GAG/DNA was noted in the co-treatment group.	Glycosaminoglycans	56-74	melanoma antigen	Mus musculus	110-113
16242683-1	2005	A trinucleotide deletion of GAG in the DYT1 gene that encodes torsinA protein is implicated in the neurological movement disorder of Oppenheim"s early-onset dystonia.	trinucleotide	2-15	melanoma antigen	Mus musculus	28-31
15920718-6	2005	Reverse transcriptase (RT)-polymerase chain reactions (PCR) detected fully-processed MRP/plf-mRNA 16-48 h after TPA treatments in five of six animals, and in three of six BPO-treated animals.	Tetradecanoylphorbol Acetate	112-115	melanoma antigen	Mus musculus	0-21
12029153-4	2002	After intranasal immunization with a recombinant SeV expressing simian immunodeficiency virus Gag protein, SeV-Gag, robust gag expression was observed in the nasal mucosa and much lower but significant levels of gag expression were observed in the local retropharyngeal and submandibular lymph nodes (LN).	Glycosaminoglycans	123-126	melanoma antigen	Mus musculus	111-114
15380359-4	2004	Analysis of immune responses induced by DNA immunization of mice showed that the DNA construct for the Tyr mutant Env induced moderately higher levels of T cell responses.	Tyrosine	103-106	melanoma antigen	Mus musculus	114-117
14502601-2	2003	In an attempt to establish whether this activity plays a role in early embryonic development, we have blocked the endogenous RT by two independent approaches: (1) embryos were exposed to nevirapine, a highly specific nonnucleoside inhibitor of RT activity; (2) anti-RT antibody was microinjected into the nucleus of one blastomere of 2-cell embryos.	Nevirapine	187-197	melanoma antigen	Mus musculus	125-127
14502601-2	2003	In an attempt to establish whether this activity plays a role in early embryonic development, we have blocked the endogenous RT by two independent approaches: (1) embryos were exposed to nevirapine, a highly specific nonnucleoside inhibitor of RT activity; (2) anti-RT antibody was microinjected into the nucleus of one blastomere of 2-cell embryos.	Nevirapine	187-197	melanoma antigen	Mus musculus	244-246
14502601-2	2003	In an attempt to establish whether this activity plays a role in early embryonic development, we have blocked the endogenous RT by two independent approaches: (1) embryos were exposed to nevirapine, a highly specific nonnucleoside inhibitor of RT activity; (2) anti-RT antibody was microinjected into the nucleus of one blastomere of 2-cell embryos.	Nevirapine	187-197	melanoma antigen	Mus musculus	244-246
12560569-0	2003	The proline-rich region of the ecotropic Moloney murine leukaemia virus envelope protein tolerates the insertion of the green fluorescent protein and allows the generation of replication-competent virus.	Proline	4-11	melanoma antigen	Mus musculus	72-88
12560569-2	2003	Insertion of these sequences into the proline-rich region (PRR) of Env resulted in a chimeric GFP-Env protein that allowed retrovirus vector transduction of murine cells with titres similar to wild-type Env.	Proline	38-45	melanoma antigen	Mus musculus	67-70
12560569-2	2003	Insertion of these sequences into the proline-rich region (PRR) of Env resulted in a chimeric GFP-Env protein that allowed retrovirus vector transduction of murine cells with titres similar to wild-type Env.	Proline	38-45	melanoma antigen	Mus musculus	98-101
12560569-2	2003	Insertion of these sequences into the proline-rich region (PRR) of Env resulted in a chimeric GFP-Env protein that allowed retrovirus vector transduction of murine cells with titres similar to wild-type Env.	Proline	38-45	melanoma antigen	Mus musculus	98-101
15905562-6	2005	We next performed adoptive transfer studies in mice to evaluate the functional capacity of hexon- and fiber-specific NAbs to suppress the immunogenicity of a prototype rAd5-Env vaccine.	nabs	117-121	melanoma antigen	Mus musculus	173-176
15840168-0	2005	Amphotropic murine leukaemia virus envelope protein is associated with cholesterol-rich microdomains.	Cholesterol	71-82	melanoma antigen	Mus musculus	35-51
15840168-4	2005	Using density gradient centrifugation and immunocytochemical analyses, we show that Env co-localizes with cholesterol, ganglioside GM1 and caveolin-1 in these specific regions of the plasma membrane.	Cholesterol	106-117	melanoma antigen	Mus musculus	84-87
15840168-4	2005	Using density gradient centrifugation and immunocytochemical analyses, we show that Env co-localizes with cholesterol, ganglioside GM1 and caveolin-1 in these specific regions of the plasma membrane.	Gangliosides	119-130	melanoma antigen	Mus musculus	84-87
15840168-5	2005	CONCLUSIONS: These results show that a large amount of A-MLV Env is associated with lipid rafts and suggest that cholesterol-rich microdomains are used as portals for the exit of A-MLV.	Cholesterol	113-124	melanoma antigen	Mus musculus	61-64
14685283-0	2004	Isomerization of the intersubunit disulphide-bond in Env controls retrovirus fusion.	disulphide	34-44	melanoma antigen	Mus musculus	53-56
14685283-2	2004	We show here that all Env subunits of the virus form disulphide-linked SU-TM complexes that can be disrupted by treatment with NP-40, heat or urea, or by Ca(2+) depletion.	disulphide	53-63	melanoma antigen	Mus musculus	22-25
14685283-2	2004	We show here that all Env subunits of the virus form disulphide-linked SU-TM complexes that can be disrupted by treatment with NP-40, heat or urea, or by Ca(2+) depletion.	su-tm	71-76	melanoma antigen	Mus musculus	22-25
14685283-2	2004	We show here that all Env subunits of the virus form disulphide-linked SU-TM complexes that can be disrupted by treatment with NP-40, heat or urea, or by Ca(2+) depletion.	Nonidet P-40	127-132	melanoma antigen	Mus musculus	22-25
14685283-2	2004	We show here that all Env subunits of the virus form disulphide-linked SU-TM complexes that can be disrupted by treatment with NP-40, heat or urea, or by Ca(2+) depletion.	Urea	142-146	melanoma antigen	Mus musculus	22-25
14685283-7	2004	DTT treatment of alkylated Env resulted in cleavage of the SU-TM disulphide-bond and rescue of virus fusion.	Dithiothreitol	0-3	melanoma antigen	Mus musculus	27-30
14685283-7	2004	DTT treatment of alkylated Env resulted in cleavage of the SU-TM disulphide-bond and rescue of virus fusion.	su-tm disulphide	59-75	melanoma antigen	Mus musculus	27-30
14685283-9	2004	These results suggest that Env is stabilized by Ca(2+) and that receptor binding triggers a cascade of reactions involving Ca(2+) removal, CXXC-thiol exposure, SU-TM disulphide-bond isomerization and SU dissociation, which lead to fusion activation.	Sulfhydryl Compounds	144-149	melanoma antigen	Mus musculus	27-30
14685283-9	2004	These results suggest that Env is stabilized by Ca(2+) and that receptor binding triggers a cascade of reactions involving Ca(2+) removal, CXXC-thiol exposure, SU-TM disulphide-bond isomerization and SU dissociation, which lead to fusion activation.	su-tm disulphide	160-176	melanoma antigen	Mus musculus	27-30
15237222-4	2004	RT was inhibited in normal and transformed cell lines by exposure to nevirapine, a non-nucleosidic RT inhibitor.	Nevirapine	69-79	melanoma antigen	Mus musculus	0-2
15237222-4	2004	RT was inhibited in normal and transformed cell lines by exposure to nevirapine, a non-nucleosidic RT inhibitor.	Nevirapine	69-79	melanoma antigen	Mus musculus	99-101
12787669-4	2003	In contrast, enzyme variants carrying E-->A, E-->D or E-->Q exchanges of the ENV glutamate are catalytically almost inactive, demonstrating that this residue has a central function in catalysis.	Glutamic Acid	90-99	melanoma antigen	Mus musculus	86-89
12787669-6	2003	Whereas wild-type Dnmt3a and the ENV variants form covalent complexes with 5-fluorocytidine modified DNA, the PCN variant does not.	5-fluorocytidine	75-91	melanoma antigen	Mus musculus	33-36
12388809-6	2002	Analysis of the JSRV env gene revealed a conserved tyrosine (597) and methionine (600) residue in the cytoplasmic tail within the transmembrane domain of the envelope, which creates a known binding site of SH2 domains in the p85 subunit of phosphatidylinositol 3-kinase.	Tyrosine	51-59	melanoma antigen	Mus musculus	21-24
12388809-6	2002	Analysis of the JSRV env gene revealed a conserved tyrosine (597) and methionine (600) residue in the cytoplasmic tail within the transmembrane domain of the envelope, which creates a known binding site of SH2 domains in the p85 subunit of phosphatidylinositol 3-kinase.	Methionine	70-80	melanoma antigen	Mus musculus	21-24
12388809-9	2002	These results are in contrast to mutational analysis performed in JSRV env-transformed murine NIH-3T3 cells in which both the tyrosine and methionine residues are necessary for transformation.	Tyrosine	126-134	melanoma antigen	Mus musculus	71-74
12388809-9	2002	These results are in contrast to mutational analysis performed in JSRV env-transformed murine NIH-3T3 cells in which both the tyrosine and methionine residues are necessary for transformation.	Methionine	139-149	melanoma antigen	Mus musculus	71-74
12029153-4	2002	After intranasal immunization with a recombinant SeV expressing simian immunodeficiency virus Gag protein, SeV-Gag, robust gag expression was observed in the nasal mucosa and much lower but significant levels of gag expression were observed in the local retropharyngeal and submandibular lymph nodes (LN).	Glycosaminoglycans	212-215	melanoma antigen	Mus musculus	94-97
12566710-4	2002	Mice vaccinated by syngag but not wt gag developed substantial and highly consistent Gag-specific antibody titers showing a clear T helper 1 polarization even with low doses of DNA.	Glycosaminoglycans	85-88	melanoma antigen	Mus musculus	22-25
11818148-1	2002	Induction of mucosal immunity to the human immunodeficiency virus (HIV) envelope (env; gp160) glycoprotein has been demonstrated with orally administered recombinant vaccinia virus (rVV) vectors and poly(DL-lactide-co-glycolide) (PLG)-encapsulated plasmid DNA expressing gp160.	poly(dl-lactide-co-glycolide	199-227	melanoma antigen	Mus musculus	72-75
12180024-0	2002	[Effect of 5-azacytidine on expression of DNA sequences homologous to ENV gene of murine mammary tumor virus in normal human lymphocytes].	Azacitidine	11-24	melanoma antigen	Mus musculus	70-73
9621020-0	1998	The neuroinvasiveness of a murine retrovirus is influenced by a dileucine-containing sequence in the cytoplasmic tail of glycosylated Gag.	dileucine	64-73	melanoma antigen	Mus musculus	134-137
10627570-8	2000	Biochemical analysis of the Cas-Br-E Env isoforms indicated that they result from differential processing of N-linked sugars.	n-linked sugars	109-124	melanoma antigen	Mus musculus	37-40
10516046-3	1999	Substitution of glycine (G) for tryptophan (W) at this position (W102G Env) in the nonpathogenic MLV FB29 induces both syncytium formation and neurologic disease in vivo.	Glycine	16-23	melanoma antigen	Mus musculus	71-74
10516046-3	1999	Substitution of glycine (G) for tryptophan (W) at this position (W102G Env) in the nonpathogenic MLV FB29 induces both syncytium formation and neurologic disease in vivo.	Tryptophan	32-42	melanoma antigen	Mus musculus	71-74
11314003-3	2001	The genomes of the two viruses differ in a single base pair: the deduced Glu(62) of the Mos residue of the R7Delta447 Gag-tMos protein is changed to Lys(62).	Glutamic Acid	73-76	melanoma antigen	Mus musculus	118-121
11314003-3	2001	The genomes of the two viruses differ in a single base pair: the deduced Glu(62) of the Mos residue of the R7Delta447 Gag-tMos protein is changed to Lys(62).	Lysine	149-152	melanoma antigen	Mus musculus	118-121
12687158-4	2000	Blocking of endogenous retroviral MCF env gene expression on the activated hemopoietic progenitors by antisense oligonucleotides inhibited their proliferation.	Oligonucleotides	112-128	melanoma antigen	Mus musculus	38-41
10766351-9	2000	Polynucleotide immunization with DNA encoding the env polypeptide resulted in strong and specific antibody responses to this self Ag in all immunized mice.	Polynucleotides	0-14	melanoma antigen	Mus musculus	50-53
10648178-1	2000	In this report, we described induction of HIV envelope (env)-specific systemic and mucosal immune responses by oral vaccination of BALB/c mice with env-encoded plasmid DNA encapsulated in poly(dl-lactide-co-glycolide) (PLG) microparticles.	poly(dl-lactide-co-glycolide	188-216	melanoma antigen	Mus musculus	46-49
10648178-1	2000	In this report, we described induction of HIV envelope (env)-specific systemic and mucosal immune responses by oral vaccination of BALB/c mice with env-encoded plasmid DNA encapsulated in poly(dl-lactide-co-glycolide) (PLG) microparticles.	poly(dl-lactide-co-glycolide	188-216	melanoma antigen	Mus musculus	56-59
9621020-9	1998	These mutations disrupted the KP sequence E53FLL56, the leucine dipeptide of which suggests the possibility that it may represent a sorting signal for glycosylated Gag.	Leucine	56-63	melanoma antigen	Mus musculus	164-167
9621020-9	1998	These mutations disrupted the KP sequence E53FLL56, the leucine dipeptide of which suggests the possibility that it may represent a sorting signal for glycosylated Gag.	Dipeptides	64-73	melanoma antigen	Mus musculus	164-167
9212906-4	1997	In this study, a 25-mer PS oligonucleotide (GEM91) complementary to the gag gene mRNA of the human immunodeficiency virus (HIV-1) was administered to mice through intravenous injections to investigate its metabolism.	ps oligonucleotide	24-42	melanoma antigen	Mus musculus	72-75
9281515-8	1997	Insertion of an additional base next to the frameshift signal placed gag and pro in the same ORF and resulted in predominant formation of Gag-PR and Gag-PR-Pol polyproteins which were not processed following in vitro translation.	Proline	77-80	melanoma antigen	Mus musculus	138-141
9281515-8	1997	Insertion of an additional base next to the frameshift signal placed gag and pro in the same ORF and resulted in predominant formation of Gag-PR and Gag-PR-Pol polyproteins which were not processed following in vitro translation.	Proline	77-80	melanoma antigen	Mus musculus	149-152
9188605-1	1997	The neuroinvasiveness of a chimeric murine retrovirus, CasFrKP (KP), is dependent on the expression of glycosylated Gag (gp85gag).	Glycosaminoglycans	116-119	melanoma antigen	Mus musculus	121-128
7544089-0	1995	Expression of a reverse transcriptase activity in a cell line established from peritoneal macrophages of mice treated with N-methyl-N-nitrosourea.	Methylnitrosourea	123-145	melanoma antigen	Mus musculus	16-37
8637720-0	1996	Analysis of chimeric Gag-Arg/Abl molecules indicates a distinct negative regulatory role for the Arg C-terminal domain.	Arginine	25-28	melanoma antigen	Mus musculus	21-24
8637720-0	1996	Analysis of chimeric Gag-Arg/Abl molecules indicates a distinct negative regulatory role for the Arg C-terminal domain.	Arginine	97-100	melanoma antigen	Mus musculus	21-24
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	33-36	melanoma antigen	Mus musculus	29-32
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	melanoma antigen	Mus musculus	112-115
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	melanoma antigen	Mus musculus	112-115
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	melanoma antigen	Mus musculus	112-115
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	melanoma antigen	Mus musculus	112-115
8038719-5	1994	Cloning and sequencing of this p12 gag homologue has revealed a high (63% to 89%) amino acid derived sequence identity with other retroviruses and shown that the major differences among p12 of pathogenic viral strains compared to non-pathogenic ones consist of a four amino acids deletion and a high abundance of proline and basic amino acids in their p12 region.	Proline	313-320	melanoma antigen	Mus musculus	35-38
8041748-5	1994	Phosphate uptake was reduced by > 50% in mouse fibroblasts expressing amphotropic envelope glycoprotein, which binds to Ram-1, indicating that Ram-1 is a major phosphate transporter in these cells.	Phosphates	0-9	melanoma antigen	Mus musculus	85-106
8038719-5	1994	Cloning and sequencing of this p12 gag homologue has revealed a high (63% to 89%) amino acid derived sequence identity with other retroviruses and shown that the major differences among p12 of pathogenic viral strains compared to non-pathogenic ones consist of a four amino acids deletion and a high abundance of proline and basic amino acids in their p12 region.	Amino Acids, Basic	325-342	melanoma antigen	Mus musculus	35-38
8191785-5	1994	Sequencing of the envelope protein gene of the virulent TBE strain 4387 showed 3 amino acid codon differences from western European TBE virus strain Neudorfl, which is also virulent for mice.	tbe	56-59	melanoma antigen	Mus musculus	18-34
8510938-3	1993	v-akt encodes a 105 kilodalton (kd) Gag-Akt fusion protein which is phosphorylated on serine and threonine residues.	Serine	86-92	melanoma antigen	Mus musculus	36-39
8510938-3	1993	v-akt encodes a 105 kilodalton (kd) Gag-Akt fusion protein which is phosphorylated on serine and threonine residues.	Threonine	97-106	melanoma antigen	Mus musculus	36-39
1585654-6	1992	Since PLAP ordinarily is transferred to a phosphatidyl-inositol glycan tail (PIG-tail) in the Golgi and then transported to the plasma membrane, it appears that Golgi-localized PLAP-env fusions are processed imperfectly.	Glycosylphosphatidylinositols	42-70	melanoma antigen	Mus musculus	182-185
7686091-0	1993	Administration of a phosphorothioate oligonucleotide antisense to murine endogenous retroviral MCF env causes immune effects in vivo in a sequence-specific manner.	Phosphorothioate Oligonucleotides	20-52	melanoma antigen	Mus musculus	99-102
1644239-3	1992	Islets of non-obese diabetic mice which were treated with cyclophosphamide, known to accelerate the development of insulitis and diabetes mellitus, have shown both a significantly increased number of retrovirus-like particles (type C) and enhanced expression of gag protein p30, compared to those of mice not treated with cyclophosphamide.	Cyclophosphamide	58-74	melanoma antigen	Mus musculus	262-265
1779889-3	1991	Increase in [3H]thymidine uptake by splenic lymphocytes following p24 antigen stimulation was most evident in mice infected with vac-gag/pol.	Tritium	13-15	melanoma antigen	Mus musculus	129-140
1937957-5	1991	In addition, pentoxifylline-treated cell GAG synthesis was reduced by 36%, and the charge density of chondroitin sulphate reduced, while tumour-cell aggregation and adhesion to subendothelial extracellular matrix was increased, as was the tumour-cell-mediated release of 35SO4 from radiolabelled subendothelial matrix.	Pentoxifylline	13-27	melanoma antigen	Mus musculus	41-44
1708335-8	1991	On the other hand, after incubating EGF with 0.5 M NaCl fraction, the angiogenic activity of EGF was identified with the precipitate (GAG fraction) of the cetylpyridinium chloride-treated reaction mixtures.	Sodium Chloride	51-55	melanoma antigen	Mus musculus	134-137
1708335-8	1991	On the other hand, after incubating EGF with 0.5 M NaCl fraction, the angiogenic activity of EGF was identified with the precipitate (GAG fraction) of the cetylpyridinium chloride-treated reaction mixtures.	Cetylpyridinium	155-179	melanoma antigen	Mus musculus	134-137
1779889-3	1991	Increase in [3H]thymidine uptake by splenic lymphocytes following p24 antigen stimulation was most evident in mice infected with vac-gag/pol.	Thymidine	16-25	melanoma antigen	Mus musculus	129-140
2243376-2	1990	Sequencing of this defective viral genome revealed a long open reading frame which encodes a putative gag/fusion protein, N-MA-p12-CA-NC-COOH, (D. C. Aziz, Z. Hanna, and P. Jolicoeur, Nature (London) 338:505-508, 1989).	Carbonic Acid	137-141	melanoma antigen	Mus musculus	102-105
1984656-3	1991	The viral genetic determinants responsible for hindlimb paralysis in BALB/c and CFW/D mice have been localized to two point mutations in the env gene: one results in a Val-25----IIe substitution in the envelope precursor polyprotein gPr80env and the other, in an Arg-430----Lys substitution in the gp70.	Valine	168-171	melanoma antigen	Mus musculus	141-144
34156262-4	2021	Three mouse NAbs potently neutralized BG505.T332N by recognizing a glycan epitope centered in the C3/V4 region on BG505 Env, as revealed by electron microscopy (EM), X-ray crystallography, and epitope mapping.	bg505	38-43	melanoma antigen	Mus musculus	120-123
2174368-3	1990	The viral envelope glycoprotein was isolated from the lysates by immunoaffinity chromatography and purified by preparative SDS/PAGE.	Sodium Dodecyl Sulfate	123-126	melanoma antigen	Mus musculus	10-31
2174368-9	1990	Thus, the results reveal that predominantly, the complex type N-glycans of the retroviral envelope glycoprotein display cell-specific variations including differences in oligosaccharide branching, sialylation and substitution by additional Gal(alpha 1-3) residues.	n-glycans	62-71	melanoma antigen	Mus musculus	90-111
2174368-9	1990	Thus, the results reveal that predominantly, the complex type N-glycans of the retroviral envelope glycoprotein display cell-specific variations including differences in oligosaccharide branching, sialylation and substitution by additional Gal(alpha 1-3) residues.	Oligosaccharides	170-185	melanoma antigen	Mus musculus	90-111
2174368-9	1990	Thus, the results reveal that predominantly, the complex type N-glycans of the retroviral envelope glycoprotein display cell-specific variations including differences in oligosaccharide branching, sialylation and substitution by additional Gal(alpha 1-3) residues.	cyclohexenoesculetin-beta-galactoside	240-243	melanoma antigen	Mus musculus	90-111
33801906-5	2021	Furthermore, Env was stabilized on the VLP surface by introducing an interchain disulfide and proline substitution (SOSIP) mutations typically employed to stabilize soluble Env trimers.	Disulfides	80-89	melanoma antigen	Mus musculus	13-16
33801906-5	2021	Furthermore, Env was stabilized on the VLP surface by introducing an interchain disulfide and proline substitution (SOSIP) mutations typically employed to stabilize soluble Env trimers.	Proline	94-101	melanoma antigen	Mus musculus	13-16
33801906-8	2021	The mVLPs bearing HA-TMCT-modified Env consistently induced anti-Env antibody responses that mediated modest neutralization activity.	ha-tmct	18-25	melanoma antigen	Mus musculus	35-38
33801906-8	2021	The mVLPs bearing HA-TMCT-modified Env consistently induced anti-Env antibody responses that mediated modest neutralization activity.	ha-tmct	18-25	melanoma antigen	Mus musculus	65-68
33810045-8	2021	Most importantly, DET and DETD-35 inhibited lung metastasis of A375LM5IF4g/Luc in NOD/SCID mice through inhibiting pulmonary vascular permeability and melanoma cell (Mel-A+) proliferation, angiogenesis (VEGF+, CD31+) and EMT (N-cadherin) in the tumor microenvironment in the lungs.	detd-35	26-33	melanoma antigen	Mus musculus	166-171
34156262-4	2021	Three mouse NAbs potently neutralized BG505.T332N by recognizing a glycan epitope centered in the C3/V4 region on BG505 Env, as revealed by electron microscopy (EM), X-ray crystallography, and epitope mapping.	Polysaccharides	67-73	melanoma antigen	Mus musculus	120-123
34156262-4	2021	Three mouse NAbs potently neutralized BG505.T332N by recognizing a glycan epitope centered in the C3/V4 region on BG505 Env, as revealed by electron microscopy (EM), X-ray crystallography, and epitope mapping.	bg505	114-119	melanoma antigen	Mus musculus	120-123
34156262-6	2021	Neutralization assays against BG505.T332N variants confirmed that potent rabbit NAbs targeted previously described glycan holes on BG505 Env and accounted for a significant portion of the autologous NAb response in both the trimer and ferritin NP groups.	bg505	30-35	melanoma antigen	Mus musculus	137-140
34156262-6	2021	Neutralization assays against BG505.T332N variants confirmed that potent rabbit NAbs targeted previously described glycan holes on BG505 Env and accounted for a significant portion of the autologous NAb response in both the trimer and ferritin NP groups.	Polysaccharides	115-121	melanoma antigen	Mus musculus	137-140
34156262-12	2021	In the present study, monoclonal NAbs were isolated from previously immunized mice and rabbits for structural and functional analyses, which revealed that potent mouse NAbs recognize the C3/V4 region and small NP-elicited rabbit NAbs primarily target known glycan holes on BG505 Env.	Polysaccharides	257-263	melanoma antigen	Mus musculus	279-282
34156262-12	2021	In the present study, monoclonal NAbs were isolated from previously immunized mice and rabbits for structural and functional analyses, which revealed that potent mouse NAbs recognize the C3/V4 region and small NP-elicited rabbit NAbs primarily target known glycan holes on BG505 Env.	bg505	273-278	melanoma antigen	Mus musculus	279-282