PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 12223091-1 2002 Urea-induced aggregation of chicken liver fatty acid synthase [acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolyzing), EC 2.3.1.85] was studied. Urea 0-4 fatty acid synthase Gallus gallus 42-61 17574488-5 2007 The results showed that DHEA decreased the concentration of triacyglycerol in the blood and the content in liver, and the mRNA levels of ACC, FAS, ME, SREBP-1c and apoB. Dehydroepiandrosterone 24-28 fatty acid synthase Gallus gallus 142-145 12531252-5 2003 Tests of fast- and slow-binding inhibitions showed that fatty acid synthase of chicken liver is rapidly and irreversibly inactivated by low Zn(2+) concentrations. Zinc 140-142 fatty acid synthase Gallus gallus 56-75 12223091-3 2002 Methyl-beta-cyclodextrin and some osmolytes, such as glycerol, sucrose, proline, glycine, and heparin, could effectively prevent the aggregation, implying an artificial chaperone role of those substances during fatty acid synthase unfolding. methyl-beta-cyclodextrin 0-24 fatty acid synthase Gallus gallus 211-230 12223091-3 2002 Methyl-beta-cyclodextrin and some osmolytes, such as glycerol, sucrose, proline, glycine, and heparin, could effectively prevent the aggregation, implying an artificial chaperone role of those substances during fatty acid synthase unfolding. Glycerol 53-61 fatty acid synthase Gallus gallus 211-230 12223091-3 2002 Methyl-beta-cyclodextrin and some osmolytes, such as glycerol, sucrose, proline, glycine, and heparin, could effectively prevent the aggregation, implying an artificial chaperone role of those substances during fatty acid synthase unfolding. Sucrose 63-70 fatty acid synthase Gallus gallus 211-230 12223091-3 2002 Methyl-beta-cyclodextrin and some osmolytes, such as glycerol, sucrose, proline, glycine, and heparin, could effectively prevent the aggregation, implying an artificial chaperone role of those substances during fatty acid synthase unfolding. Proline 72-79 fatty acid synthase Gallus gallus 211-230 12223091-3 2002 Methyl-beta-cyclodextrin and some osmolytes, such as glycerol, sucrose, proline, glycine, and heparin, could effectively prevent the aggregation, implying an artificial chaperone role of those substances during fatty acid synthase unfolding. Glycine 81-88 fatty acid synthase Gallus gallus 211-230 12223091-3 2002 Methyl-beta-cyclodextrin and some osmolytes, such as glycerol, sucrose, proline, glycine, and heparin, could effectively prevent the aggregation, implying an artificial chaperone role of those substances during fatty acid synthase unfolding. Heparin 94-101 fatty acid synthase Gallus gallus 211-230 11700039-0 2001 Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase. epigallocatechin gallate 10-34 fatty acid synthase Gallus gallus 59-78 11700039-1 2001 We discover that epigallocatechin gallate (EGCG) from green tea is an inhibitor of fatty-acid synthase (FAS) from chicken liver. epigallocatechin gallate 17-41 fatty acid synthase Gallus gallus 83-102 11700039-1 2001 We discover that epigallocatechin gallate (EGCG) from green tea is an inhibitor of fatty-acid synthase (FAS) from chicken liver. epigallocatechin gallate 17-41 fatty acid synthase Gallus gallus 104-107 11700039-1 2001 We discover that epigallocatechin gallate (EGCG) from green tea is an inhibitor of fatty-acid synthase (FAS) from chicken liver. epigallocatechin gallate 43-47 fatty acid synthase Gallus gallus 83-102 11566373-0 2001 Unfolding and inactivation of fatty acid synthase from chicken liver during urea denaturation. Urea 76-80 fatty acid synthase Gallus gallus 30-49 11700039-1 2001 We discover that epigallocatechin gallate (EGCG) from green tea is an inhibitor of fatty-acid synthase (FAS) from chicken liver. epigallocatechin gallate 43-47 fatty acid synthase Gallus gallus 104-107 11700039-2 2001 Its inhibition of FAS is composed of reversible fast-binding inhibition, through which 52 microM EGCG can inhibit 50% of the activity of FAS, and irreversible slow-binding inactivation following saturation kinetics with the dissociation constant of 0.352 mM and limiting rate constant of 0.0168 min(-1). epigallocatechin gallate 97-101 fatty acid synthase Gallus gallus 18-21 11700039-2 2001 Its inhibition of FAS is composed of reversible fast-binding inhibition, through which 52 microM EGCG can inhibit 50% of the activity of FAS, and irreversible slow-binding inactivation following saturation kinetics with the dissociation constant of 0.352 mM and limiting rate constant of 0.0168 min(-1). epigallocatechin gallate 97-101 fatty acid synthase Gallus gallus 137-140 11566373-1 2001 The inactivation and conformational changes of the multifunctional fatty acid synthase (acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolyzing), EC 2.3.1.85) from chicken liver have been studied in urea solution. Urea 254-258 fatty acid synthase Gallus gallus 67-86 11566373-2 2001 The results show that complete inactivation of the fatty acid synthase occurs before obvious conformational changes with regard to the overall, beta-ketoacyl reduction and acetoacetyl-CoA reduction reactions. beta-ketoacyl 144-157 fatty acid synthase Gallus gallus 51-70 11566373-8 2001 The aggregation phenomenon of the fatty acid synthase in a certain concentration range of urea (3-4 M) was also observed during unfolding. Urea 90-94 fatty acid synthase Gallus gallus 34-53 1680129-0 1991 Triiodothyronine-induced accumulations of malic enzyme, fatty acid synthase, acetyl-coenzyme A carboxylase, and their mRNAs are blocked by protein kinase inhibitors. Triiodothyronine 0-16 fatty acid synthase Gallus gallus 56-75 9924801-0 1998 Inactivation and conformational changes of fatty acid synthase from chicken liver during unfolding by sodium dodecyl sulfate. Sodium Dodecyl Sulfate 102-124 fatty acid synthase Gallus gallus 43-62 9924801-2 1998 The inactivation and conformational changes of the multifunctional fatty acid synthase from chicken liver in SDS solutions have been studied. Sodium Dodecyl Sulfate 109-112 fatty acid synthase Gallus gallus 67-86 9530133-3 1998 In the presence of triiodothyronine, glucose (25 mM) stimulated an increase in the activity and mRNA abundance of FAS and ME. Triiodothyronine 19-35 fatty acid synthase Gallus gallus 114-117 9530133-3 1998 In the presence of triiodothyronine, glucose (25 mM) stimulated an increase in the activity and mRNA abundance of FAS and ME. Glucose 37-44 fatty acid synthase Gallus gallus 114-117 9530133-5 1998 Xylitol mimicked the effects of glucose on FAS and ME expression, suggesting that an intermediate of the pentose phosphate pathway may be involved in mediating this response. Xylitol 0-7 fatty acid synthase Gallus gallus 43-46 9530133-5 1998 Xylitol mimicked the effects of glucose on FAS and ME expression, suggesting that an intermediate of the pentose phosphate pathway may be involved in mediating this response. Glucose 32-39 fatty acid synthase Gallus gallus 43-46 9530133-5 1998 Xylitol mimicked the effects of glucose on FAS and ME expression, suggesting that an intermediate of the pentose phosphate pathway may be involved in mediating this response. Pentosephosphates 105-122 fatty acid synthase Gallus gallus 43-46 9530133-6 1998 The effects of glucose on the mRNA abundance of FAS and ME were accompanied by similar changes in transcription of FAS and ME. Glucose 15-22 fatty acid synthase Gallus gallus 48-51 9530133-6 1998 The effects of glucose on the mRNA abundance of FAS and ME were accompanied by similar changes in transcription of FAS and ME. Glucose 15-22 fatty acid synthase Gallus gallus 115-118 9530133-7 1998 These data support the hypothesis that glucose plays a role in mediating the effects of nutritional manipulation on transcription of FAS and ME in liver. Glucose 39-46 fatty acid synthase Gallus gallus 133-136 7623781-1 1995 The effect of triiodothyronine (T3) on regulation of fatty acid synthase in chicken liver was investigated. Triiodothyronine 14-30 fatty acid synthase Gallus gallus 53-72 7623781-1 1995 The effect of triiodothyronine (T3) on regulation of fatty acid synthase in chicken liver was investigated. Triiodothyronine 32-34 fatty acid synthase Gallus gallus 53-72 1586154-0 1992 Regulation of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture: corticosterone and carnitine regulate responsiveness to triiodothyronine. Corticosterone 101-115 fatty acid synthase Gallus gallus 35-54 1586154-0 1992 Regulation of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture: corticosterone and carnitine regulate responsiveness to triiodothyronine. Carnitine 120-129 fatty acid synthase Gallus gallus 35-54 1586154-0 1992 Regulation of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture: corticosterone and carnitine regulate responsiveness to triiodothyronine. Triiodothyronine 157-173 fatty acid synthase Gallus gallus 35-54 9530133-0 1998 Glucose stimulates transcription of fatty acid synthase and malic enzyme in avian hepatocytes. Glucose 0-7 fatty acid synthase Gallus gallus 36-55 9530133-1 1998 Transcription of fatty acid synthase (FAS) and malic enzyme (ME) in avian liver is low during starvation or feeding a low-carbohydrate, high-fat diet and high during feeding a high-carbohydrate, low-fat diet. Carbohydrates 122-134 fatty acid synthase Gallus gallus 17-36 9530133-1 1998 Transcription of fatty acid synthase (FAS) and malic enzyme (ME) in avian liver is low during starvation or feeding a low-carbohydrate, high-fat diet and high during feeding a high-carbohydrate, low-fat diet. Carbohydrates 122-134 fatty acid synthase Gallus gallus 38-41 9530133-1 1998 Transcription of fatty acid synthase (FAS) and malic enzyme (ME) in avian liver is low during starvation or feeding a low-carbohydrate, high-fat diet and high during feeding a high-carbohydrate, low-fat diet. Carbohydrates 181-193 fatty acid synthase Gallus gallus 17-36 9530133-1 1998 Transcription of fatty acid synthase (FAS) and malic enzyme (ME) in avian liver is low during starvation or feeding a low-carbohydrate, high-fat diet and high during feeding a high-carbohydrate, low-fat diet. Carbohydrates 181-193 fatty acid synthase Gallus gallus 38-41 9530133-2 1998 The role of glucose in the nutritional control of FAS and ME was investigated by determining the effects of this metabolic fuel on expression of FAS and ME in primary cultures of chick embryo hepatocytes. Glucose 12-19 fatty acid synthase Gallus gallus 50-53 7945243-0 1994 Zinc, vanadate and selenate inhibit the tri-iodothyronine-induced expression of fatty acid synthase and malic enzyme in chick-embryo hepatocytes in culture. Vanadates 6-14 fatty acid synthase Gallus gallus 80-99 7945243-0 1994 Zinc, vanadate and selenate inhibit the tri-iodothyronine-induced expression of fatty acid synthase and malic enzyme in chick-embryo hepatocytes in culture. Selenic Acid 19-27 fatty acid synthase Gallus gallus 80-99 7945243-0 1994 Zinc, vanadate and selenate inhibit the tri-iodothyronine-induced expression of fatty acid synthase and malic enzyme in chick-embryo hepatocytes in culture. Triiodothyronine 40-57 fatty acid synthase Gallus gallus 80-99 7945243-7 1994 We have studied the effect of zinc, vanadate and selenate on the T3-induced expression of both FAS and ME. Vanadates 36-44 fatty acid synthase Gallus gallus 95-98 7945243-7 1994 We have studied the effect of zinc, vanadate and selenate on the T3-induced expression of both FAS and ME. Selenic Acid 49-57 fatty acid synthase Gallus gallus 95-98 7945243-8 1994 Like insulin, these agents had little or no effect on the basal activities for FAS and ME in chick-embryo hepatocytes in culture for 48 h. Unlike insulin, however, zinc, vanadate and selenate inhibited the T3-induced activities and mRNA levels of both FAS and ME. Selenic Acid 183-191 fatty acid synthase Gallus gallus 252-255 7945243-10 1994 Zinc and vanadate also inhibited the T3-induced transcription of the FAS and ME genes. Vanadates 9-17 fatty acid synthase Gallus gallus 69-72 1634532-0 1992 Hexanoate and octanoate inhibit transcription of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture. hexanoic acid 0-9 fatty acid synthase Gallus gallus 70-89 1634532-0 1992 Hexanoate and octanoate inhibit transcription of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture. octanoic acid 14-23 fatty acid synthase Gallus gallus 70-89 1634532-1 1992 Hexanoate and octanoate inhibit the triiodothyronine (T3)-induced increases in the activities of malic enzyme and fatty acid synthase in chick embryo hepatocytes in culture. hexanoic acid 0-9 fatty acid synthase Gallus gallus 114-133 1634532-1 1992 Hexanoate and octanoate inhibit the triiodothyronine (T3)-induced increases in the activities of malic enzyme and fatty acid synthase in chick embryo hepatocytes in culture. octanoic acid 14-23 fatty acid synthase Gallus gallus 114-133 1634532-1 1992 Hexanoate and octanoate inhibit the triiodothyronine (T3)-induced increases in the activities of malic enzyme and fatty acid synthase in chick embryo hepatocytes in culture. Triiodothyronine 36-52 fatty acid synthase Gallus gallus 114-133 1634532-1 1992 Hexanoate and octanoate inhibit the triiodothyronine (T3)-induced increases in the activities of malic enzyme and fatty acid synthase in chick embryo hepatocytes in culture. Triiodothyronine 54-56 fatty acid synthase Gallus gallus 114-133 1634532-7 1992 2-Bromooctanoate and carnitine stimulated the T3-induced accumulation of the mRNAs for malic enzyme and fatty acid synthase. 2-bromooctanoic acid 0-16 fatty acid synthase Gallus gallus 104-123 1634532-7 1992 2-Bromooctanoate and carnitine stimulated the T3-induced accumulation of the mRNAs for malic enzyme and fatty acid synthase. Carnitine 21-30 fatty acid synthase Gallus gallus 104-123 1680129-2 1991 Addition of triiodothyronine (T3) to chick-embryo hepatocytes in culture causes increased accumulations of malic enzyme, fatty acid synthase, acetyl-CoA carboxylase and their mRNAs. Triiodothyronine 12-28 fatty acid synthase Gallus gallus 121-140 1680129-2 1991 Addition of triiodothyronine (T3) to chick-embryo hepatocytes in culture causes increased accumulations of malic enzyme, fatty acid synthase, acetyl-CoA carboxylase and their mRNAs. Triiodothyronine 30-32 fatty acid synthase Gallus gallus 121-140 1680129-6 1991 H-8 inhibited T3-induced transcription of the genes for both malic enzyme and fatty acid synthase but had little effect on transcription of the beta-actin or glyceraldehyde-3-phosphate dehydrogenase genes or on total RNA synthesis in isolated nuclei. N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide 0-3 fatty acid synthase Gallus gallus 78-97 2170411-0 1990 Triiodothyronine stimulates transcription of the fatty acid synthase gene in chick embryo hepatocytes in culture. Triiodothyronine 0-16 fatty acid synthase Gallus gallus 49-68 2170411-6 1990 In chick embryo hepatocytes in culture, the stimulatory effect of feeding on fatty acid synthase activity is mimicked by adding triiodothyronine and insulin; the inhibitory effect of starvation is mimicked by adding glucagon or cyclic AMP. Triiodothyronine 128-144 fatty acid synthase Gallus gallus 77-96 2170411-18 1990 Glucagon or dibutyryl cyclic AMP inhibit fatty acid synthase activity and mRNA level in hepatocytes in culture by 70-80% and 60%, respectively, but have no effect on transcription of the fatty acid synthase gene, suggesting a post-transcriptional mode of regulation for cyclic AMP. Cyclic AMP 22-32 fatty acid synthase Gallus gallus 41-60 2170411-6 1990 In chick embryo hepatocytes in culture, the stimulatory effect of feeding on fatty acid synthase activity is mimicked by adding triiodothyronine and insulin; the inhibitory effect of starvation is mimicked by adding glucagon or cyclic AMP. Cyclic AMP 228-238 fatty acid synthase Gallus gallus 77-96 2170411-7 1990 We now show that triiodothyronine alone stimulates transcription of fatty acid synthase by 4- to 6-fold, about the same as the increase in fatty acid synthase mRNA. Triiodothyronine 17-33 fatty acid synthase Gallus gallus 68-87 2170411-18 1990 Glucagon or dibutyryl cyclic AMP inhibit fatty acid synthase activity and mRNA level in hepatocytes in culture by 70-80% and 60%, respectively, but have no effect on transcription of the fatty acid synthase gene, suggesting a post-transcriptional mode of regulation for cyclic AMP. Glucagon 0-8 fatty acid synthase Gallus gallus 41-60 2170411-18 1990 Glucagon or dibutyryl cyclic AMP inhibit fatty acid synthase activity and mRNA level in hepatocytes in culture by 70-80% and 60%, respectively, but have no effect on transcription of the fatty acid synthase gene, suggesting a post-transcriptional mode of regulation for cyclic AMP. Bucladesine 12-32 fatty acid synthase Gallus gallus 41-60 34302249-0 2021 Nano-selenium alleviating the lipid metabolism disorder of LMH cells induced by potassium dichromate via down-regulating ACACA and FASN. Selenium 5-13 fatty acid synthase Gallus gallus 131-135 33807218-10 2021 In the breast muscle, both hesperidin and naringin increased fatty acid synthase (FASN) expression and hesperidin increased the expression of adiponectin. Hesperidin 27-37 fatty acid synthase Gallus gallus 61-80 33807218-10 2021 In the breast muscle, both hesperidin and naringin increased fatty acid synthase (FASN) expression and hesperidin increased the expression of adiponectin. Hesperidin 27-37 fatty acid synthase Gallus gallus 82-86 33807218-10 2021 In the breast muscle, both hesperidin and naringin increased fatty acid synthase (FASN) expression and hesperidin increased the expression of adiponectin. naringin 42-50 fatty acid synthase Gallus gallus 61-80 33807218-10 2021 In the breast muscle, both hesperidin and naringin increased fatty acid synthase (FASN) expression and hesperidin increased the expression of adiponectin. naringin 42-50 fatty acid synthase Gallus gallus 82-86 34302249-0 2021 Nano-selenium alleviating the lipid metabolism disorder of LMH cells induced by potassium dichromate via down-regulating ACACA and FASN. Potassium Dichromate 80-100 fatty acid synthase Gallus gallus 131-135 2804133-0 1989 Affinity labeling of chicken liver fatty acid synthase with chloroacetyl-CoA and bromopyruvate. chloroacetyl coenzyme A 60-76 fatty acid synthase Gallus gallus 35-54 34438887-9 2021 Clenbuterol administration led to a significant upregulation of hepatic PPARalpha, growth hormone receptor, and Lipoprotein lipase (LPL) mRNA expression with a marked decrease in fatty acid synthase (FAS) and sterol regulatory element-binding protein 1 (SREBP-1c) expression. Clenbuterol 0-11 fatty acid synthase Gallus gallus 179-198 34438887-9 2021 Clenbuterol administration led to a significant upregulation of hepatic PPARalpha, growth hormone receptor, and Lipoprotein lipase (LPL) mRNA expression with a marked decrease in fatty acid synthase (FAS) and sterol regulatory element-binding protein 1 (SREBP-1c) expression. Clenbuterol 0-11 fatty acid synthase Gallus gallus 200-203 2804133-0 1989 Affinity labeling of chicken liver fatty acid synthase with chloroacetyl-CoA and bromopyruvate. bromopyruvate 81-94 fatty acid synthase Gallus gallus 35-54 2804133-1 1989 Fatty acid synthase of chicken liver is inactivated rapidly and irreversibly by incubation with chloroacetyl-CoA or with bromopyruvate. chloroacetyl coenzyme A 96-112 fatty acid synthase Gallus gallus 0-19 2804133-1 1989 Fatty acid synthase of chicken liver is inactivated rapidly and irreversibly by incubation with chloroacetyl-CoA or with bromopyruvate. bromopyruvate 121-134 fatty acid synthase Gallus gallus 0-19 3207709-1 1988 The complete amino acid sequence of thioesterase domain of chicken liver fatty acid synthase has been determined by sequencing peptides produced by trypsin, Staphylococcus aureus V8 protease, and cyanogen bromide cleavage. Cyanogen Bromide 196-212 fatty acid synthase Gallus gallus 73-92 2751995-0 1989 Amino acid sequences of pyridoxal 5"-phosphate binding sites and fluorescence resonance energy transfer in chicken liver fatty acid synthase. Pyridoxal Phosphate 24-46 fatty acid synthase Gallus gallus 121-140 2751995-1 1989 The amino acid sequences associated with pyridoxal 5"-phosphate binding sites in chicken liver fatty acid synthase have been determined: a site whose modification causes selective inhibition of the enoyl reductase activity and a site (site I) that is not associated with enzymatic activity. Pyridoxal Phosphate 41-63 fatty acid synthase Gallus gallus 95-114 3207709-6 1988 The active site of the thioesterase domain of chicken fatty acid synthase was suggested to be the serine on position 101 according to its homology with other serine-type esterases and proteases which have a common structure of -Gly-X-Ser-Y-Gly- with the variable amino acids X and Y disrupting the homology. Serine 98-104 fatty acid synthase Gallus gallus 54-73 3207709-6 1988 The active site of the thioesterase domain of chicken fatty acid synthase was suggested to be the serine on position 101 according to its homology with other serine-type esterases and proteases which have a common structure of -Gly-X-Ser-Y-Gly- with the variable amino acids X and Y disrupting the homology. gly-x-ser 228-237 fatty acid synthase Gallus gallus 54-73 3207709-6 1988 The active site of the thioesterase domain of chicken fatty acid synthase was suggested to be the serine on position 101 according to its homology with other serine-type esterases and proteases which have a common structure of -Gly-X-Ser-Y-Gly- with the variable amino acids X and Y disrupting the homology. Glycine 228-231 fatty acid synthase Gallus gallus 54-73 3207710-5 1988 The DNA insert in lambda CFAS hybridizes with synthetic oligonucleotide probes prepared according to the known amino acid sequence of the thioesterase component of the chicken liver fatty acid synthase [Yang, C.-Y., Huang, W.-Y., Chirala, S., & Wakil, S.J. Oligonucleotides 56-71 fatty acid synthase Gallus gallus 182-201 3167014-1 1988 The amino acid sequences of three essential regions of chicken liver fatty acid synthase have been determined: that around 4"-phosphopantetheine ("carrier" site), the substrate "loading" site containing serine, and a "waiting" site for the growing fatty acid containing cysteine. 4'-phosphopantetheine 123-144 fatty acid synthase Gallus gallus 69-88 3167014-1 1988 The amino acid sequences of three essential regions of chicken liver fatty acid synthase have been determined: that around 4"-phosphopantetheine ("carrier" site), the substrate "loading" site containing serine, and a "waiting" site for the growing fatty acid containing cysteine. Cysteine 270-278 fatty acid synthase Gallus gallus 69-88 3167014-1 1988 The amino acid sequences of three essential regions of chicken liver fatty acid synthase have been determined: that around 4"-phosphopantetheine ("carrier" site), the substrate "loading" site containing serine, and a "waiting" site for the growing fatty acid containing cysteine. Serine 203-209 fatty acid synthase Gallus gallus 69-88 6373765-2 1984 The stopped flow method has been used to determine the pH dependence of the kinetics of the binding of NADPH to chicken liver fatty acid synthase over the pH range 6.0-8.5. NADP 103-108 fatty acid synthase Gallus gallus 126-145 3759951-0 1986 Thiol/disulfide redox equilibrium and kinetic behavior of chicken liver fatty acid synthase. Sulfhydryl Compounds 0-5 fatty acid synthase Gallus gallus 72-91 3759951-0 1986 Thiol/disulfide redox equilibrium and kinetic behavior of chicken liver fatty acid synthase. Disulfides 6-15 fatty acid synthase Gallus gallus 72-91 3759951-1 1986 Chicken liver fatty acid synthase is rapidly inactivated and cross-linked at pH 7.2 and 8.0 by incubation with low concentrations of common biological disulfides including glutathione disulfide, coenzyme A disulfide, and glutathione-coenzyme A-mixed disulfide. Disulfides 151-161 fatty acid synthase Gallus gallus 14-33 3759951-1 1986 Chicken liver fatty acid synthase is rapidly inactivated and cross-linked at pH 7.2 and 8.0 by incubation with low concentrations of common biological disulfides including glutathione disulfide, coenzyme A disulfide, and glutathione-coenzyme A-mixed disulfide. Glutathione Disulfide 172-193 fatty acid synthase Gallus gallus 14-33 3759951-1 1986 Chicken liver fatty acid synthase is rapidly inactivated and cross-linked at pH 7.2 and 8.0 by incubation with low concentrations of common biological disulfides including glutathione disulfide, coenzyme A disulfide, and glutathione-coenzyme A-mixed disulfide. Disulfides 151-160 fatty acid synthase Gallus gallus 14-33 3759951-1 1986 Chicken liver fatty acid synthase is rapidly inactivated and cross-linked at pH 7.2 and 8.0 by incubation with low concentrations of common biological disulfides including glutathione disulfide, coenzyme A disulfide, and glutathione-coenzyme A-mixed disulfide. Glutathione 172-183 fatty acid synthase Gallus gallus 14-33 3759951-1 1986 Chicken liver fatty acid synthase is rapidly inactivated and cross-linked at pH 7.2 and 8.0 by incubation with low concentrations of common biological disulfides including glutathione disulfide, coenzyme A disulfide, and glutathione-coenzyme A-mixed disulfide. Disulfides 184-193 fatty acid synthase Gallus gallus 14-33 3759951-8 1986 The equilibrium constant for the redox equilibration of fatty acid synthase in a glutathione redox buffer is 15 mM (Ered + GSSG in equilibrium Eox + 2GSH). Glutathione 81-92 fatty acid synthase Gallus gallus 56-75 3535882-0 1986 Kinetic and nuclear magnetic resonance study of the interaction of NADP+ and NADPH with chicken liver fatty acid synthase. NADP 67-72 fatty acid synthase Gallus gallus 102-121 3535882-0 1986 Kinetic and nuclear magnetic resonance study of the interaction of NADP+ and NADPH with chicken liver fatty acid synthase. NADP 77-82 fatty acid synthase Gallus gallus 102-121 3535882-1 1986 The ionic strength dependence of the second-order rate constant for the association of reduced nicotinamide adenine dinucleotide phosphate (NADPH) and chicken liver fatty acid synthase was determined. NADP 95-138 fatty acid synthase Gallus gallus 165-184 3535882-1 1986 The ionic strength dependence of the second-order rate constant for the association of reduced nicotinamide adenine dinucleotide phosphate (NADPH) and chicken liver fatty acid synthase was determined. NADP 140-145 fatty acid synthase Gallus gallus 165-184 3533937-3 1986 Triiodothyronine or insulin caused about a 2.5-fold increase in the relative rate of synthesis of fatty acid synthase. Triiodothyronine 0-16 fatty acid synthase Gallus gallus 98-117 3533937-9 1986 Thus, triiodothyronine regulates fatty acid synthase primarily by controlling the amount of its mRNA. Triiodothyronine 6-22 fatty acid synthase Gallus gallus 33-52 3533937-13 1986 After the addition of triiodothyronine, fatty acid synthase mRNA accumulated with sigmoidal kinetics, approaching a new steady state about 48 h after the addition of hormone. Triiodothyronine 22-38 fatty acid synthase Gallus gallus 40-59 3533937-15 1986 We suggest that the abundances of both fatty acid synthase and malic enzyme mRNAs are regulated by a common triiodothyronine-induced peptide intermediate which has a relatively long half-life. Triiodothyronine 108-124 fatty acid synthase Gallus gallus 39-58 3533937-16 1986 Glucagon caused an 80% decrease in the synthesis of fatty acid synthase (Fischer, P.W.F., and Goodridge, A.G. (1978) Arch. Glucagon 0-8 fatty acid synthase Gallus gallus 52-71 3531208-2 1986 The 4"-phosphopantetheine of chicken liver fatty acid synthase was specifically labeled with the fluorescent substrate analog coenzyme A 6-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]aminohexanoate at low salt concentrations. 4'-phosphopantetheine 4-25 fatty acid synthase Gallus gallus 43-62 3531208-2 1986 The 4"-phosphopantetheine of chicken liver fatty acid synthase was specifically labeled with the fluorescent substrate analog coenzyme A 6-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]aminohexanoate at low salt concentrations. 6-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]aminohexanoate 137-188 fatty acid synthase Gallus gallus 43-62 3531208-2 1986 The 4"-phosphopantetheine of chicken liver fatty acid synthase was specifically labeled with the fluorescent substrate analog coenzyme A 6-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]aminohexanoate at low salt concentrations. Salts 196-200 fatty acid synthase Gallus gallus 43-62 3531208-3 1986 A serine at the active site of the thioesterase was specifically labeled with the fluorescent compounds 6-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]aminopentylmethylphosphono fluoridate and/or pyrenebutyl methylphosphonofluoridate. Serine 2-8 fatty acid synthase Gallus gallus 35-47 3531208-3 1986 A serine at the active site of the thioesterase was specifically labeled with the fluorescent compounds 6-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]aminopentylmethylphosphono fluoridate and/or pyrenebutyl methylphosphonofluoridate. 6-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]aminopentylmethylphosphono fluoridate 104-178 fatty acid synthase Gallus gallus 35-47 3531208-3 1986 A serine at the active site of the thioesterase was specifically labeled with the fluorescent compounds 6-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]aminopentylmethylphosphono fluoridate and/or pyrenebutyl methylphosphonofluoridate. 4-(1-pyrenyl)butyl methylphosphonofluoridate 186-223 fatty acid synthase Gallus gallus 35-47 3531208-8 1986 The distance between the serine on the thioesterase and the 4"-phosphopantetheine on the same polypeptide is 48 A; again no interpolypeptide chain energy transfer was observed. Serine 25-31 fatty acid synthase Gallus gallus 39-51 3531208-9 1986 The distance between the serines of the two thioesterases within a fatty acid synthase molecule is greater than 56 A. Serine 25-32 fatty acid synthase Gallus gallus 67-86 3021196-0 1986 Interaction of spin-labeled nicotinamide adenine dinucleotide phosphate with chicken liver fatty acid synthase. NADP 28-71 fatty acid synthase Gallus gallus 91-110 3021196-1 1986 The spatial relationships between the four reduced nicotinamide adenine dinucleotide phosphate (NADPH) binding sites on chicken liver fatty acid synthase were explored with electron paramagnetic resonance (EPR) and spin-labeled analogues of NADP+. NADP 51-94 fatty acid synthase Gallus gallus 134-153 3021196-1 1986 The spatial relationships between the four reduced nicotinamide adenine dinucleotide phosphate (NADPH) binding sites on chicken liver fatty acid synthase were explored with electron paramagnetic resonance (EPR) and spin-labeled analogues of NADP+. NADP 96-101 fatty acid synthase Gallus gallus 134-153 3021196-1 1986 The spatial relationships between the four reduced nicotinamide adenine dinucleotide phosphate (NADPH) binding sites on chicken liver fatty acid synthase were explored with electron paramagnetic resonance (EPR) and spin-labeled analogues of NADP+. NADP 241-246 fatty acid synthase Gallus gallus 134-153 3525233-1 1986 The activity of hepatic fatty acid synthase (EC 2.3.1.85) correlates positively with the rate of synthesis of long-chain fatty acids. long-chain fatty acids 110-132 fatty acid synthase Gallus gallus 24-43 3541753-1 1986 The levels of malic enzyme and fatty acid synthase are increased by feeding and decreased by starvation in liver in vivo and are increased by triiodothyronine and decreased by glucagon in hepatocytes in culture. Triiodothyronine 142-158 fatty acid synthase Gallus gallus 31-50 3541753-1 1986 The levels of malic enzyme and fatty acid synthase are increased by feeding and decreased by starvation in liver in vivo and are increased by triiodothyronine and decreased by glucagon in hepatocytes in culture. Glucagon 176-184 fatty acid synthase Gallus gallus 31-50 3541753-6 1986 In chick-embryo hepatocytes incubated in serum-free medium containing insulin, triiodothyronine causes a greater than 10-fold increase in levels of both malic enzyme and fatty acid synthase mRNAs. Triiodothyronine 79-95 fatty acid synthase Gallus gallus 170-189 3541753-7 1986 Kinetic and inhibitor experiments suggest a protein intermediate in the increases of malic enzyme and fatty acid synthase mRNAs caused by triiodothyronine. Triiodothyronine 138-154 fatty acid synthase Gallus gallus 102-121 3541753-11 1986 Glucagon inhibited fatty acid synthase mRNA level by less than 50%; the inhibited step has not been identified. Glucagon 0-8 fatty acid synthase Gallus gallus 19-38 4055747-2 1985 The mechanism of acyl enzyme formation from acyl-CoA derivatives was studied for chicken liver fatty acid synthase in 0.1 M potassium phosphate (pH 7.0) and 1 mM EDTA at 23 degrees C. Three mechanistically important acyl-binding sites exist: a cysteine, 4"-phosphopantetheine, and a hydroxyl (serine). Acyl Coenzyme A 44-52 fatty acid synthase Gallus gallus 95-114 6706971-3 1984 The thioesterase component of chicken liver fatty acid synthetase was either inhibited using phenylmethanesulfonyl fluoride or diisopropyl fluorophosphate, or released from the synthetase by limited proteolysis with alpha-chymotrypsin, thus ensuring that the fatty acyl products remain bound to the enzyme. Phenylmethylsulfonyl Fluoride 93-123 fatty acid synthase Gallus gallus 4-16 6722137-1 1984 The stereochemistry of the four partial reactions catalyzed by chicken liver fatty acid synthase that lead to the synthesis of palmitic acid has been determined. Palmitic Acid 127-140 fatty acid synthase Gallus gallus 77-96 6722137-8 1984 The stereochemistry of the hydration was derived from an analysis of the spin-spin coupling constant of 3-hydroxy[2-2H]butyric acid benzylamides obtained from 3-hydroxy[2-2H]butyryl-CoA synthesized by fatty acid synthase. 3-hydroxy[2-2h]butyric acid benzylamides 104-144 fatty acid synthase Gallus gallus 201-220 6722137-8 1984 The stereochemistry of the hydration was derived from an analysis of the spin-spin coupling constant of 3-hydroxy[2-2H]butyric acid benzylamides obtained from 3-hydroxy[2-2H]butyryl-CoA synthesized by fatty acid synthase. 3-hydroxy[2-2h]butyryl-coa 159-185 fatty acid synthase Gallus gallus 201-220 6722137-10 1984 The source of all 28 prochiral hydrogens of the palmitic acid synthesized by chicken liver fatty acid synthase was inferred from the results of this work. Hydrogen 31-40 fatty acid synthase Gallus gallus 91-110 6722137-10 1984 The source of all 28 prochiral hydrogens of the palmitic acid synthesized by chicken liver fatty acid synthase was inferred from the results of this work. Palmitic Acid 48-61 fatty acid synthase Gallus gallus 91-110 6706971-3 1984 The thioesterase component of chicken liver fatty acid synthetase was either inhibited using phenylmethanesulfonyl fluoride or diisopropyl fluorophosphate, or released from the synthetase by limited proteolysis with alpha-chymotrypsin, thus ensuring that the fatty acyl products remain bound to the enzyme. Isoflurophate 127-154 fatty acid synthase Gallus gallus 4-16 6706971-8 1984 They also indicate that the thioesterase plays a key role in determining the chain specificity of fatty acid synthesis. Fatty Acids 98-108 fatty acid synthase Gallus gallus 28-40 6661183-7 1983 The results obtained with iodoacetamide show that in the dimeric fatty acid synthase modification of one cysteine-SH condensing site and/or one pantetheine-SH site per dimer is sufficient to affect inhibition of condensing activity and the activity for fatty acid synthesis, and are in accord with a recently proposed model for the mechanism of action of animal fatty acid synthases [Kumar (1982) J. Theor. Iodoacetamide 26-39 fatty acid synthase Gallus gallus 65-84 6661183-7 1983 The results obtained with iodoacetamide show that in the dimeric fatty acid synthase modification of one cysteine-SH condensing site and/or one pantetheine-SH site per dimer is sufficient to affect inhibition of condensing activity and the activity for fatty acid synthesis, and are in accord with a recently proposed model for the mechanism of action of animal fatty acid synthases [Kumar (1982) J. Theor. Cysteine 105-113 fatty acid synthase Gallus gallus 65-84 6661183-0 1983 Inhibition of the condensing component of chicken liver fatty acid synthase by iodoacetamide and 5,5"-dithiobis-(2-nitrobenzoic acid). Iodoacetamide 79-92 fatty acid synthase Gallus gallus 56-75 6661183-7 1983 The results obtained with iodoacetamide show that in the dimeric fatty acid synthase modification of one cysteine-SH condensing site and/or one pantetheine-SH site per dimer is sufficient to affect inhibition of condensing activity and the activity for fatty acid synthesis, and are in accord with a recently proposed model for the mechanism of action of animal fatty acid synthases [Kumar (1982) J. Theor. Pantetheine 144-155 fatty acid synthase Gallus gallus 65-84 6871180-0 1983 Fluorescent properties of pyrene bound at specific acylation sites of chicken liver fatty acid synthase. pyrene 26-32 fatty acid synthase Gallus gallus 84-103 6661183-0 1983 Inhibition of the condensing component of chicken liver fatty acid synthase by iodoacetamide and 5,5"-dithiobis-(2-nitrobenzoic acid). Dithionitrobenzoic Acid 97-132 fatty acid synthase Gallus gallus 56-75 6661183-1 1983 Chicken liver fatty acid synthase is inhibited by the thiol-modifying reagents 5,5"-dithiobis-(2-nitrobenzoic acid) and iodoacetamide. Sulfhydryl Compounds 54-59 fatty acid synthase Gallus gallus 14-33 6661183-1 1983 Chicken liver fatty acid synthase is inhibited by the thiol-modifying reagents 5,5"-dithiobis-(2-nitrobenzoic acid) and iodoacetamide. Dithionitrobenzoic Acid 79-115 fatty acid synthase Gallus gallus 14-33 6661183-1 1983 Chicken liver fatty acid synthase is inhibited by the thiol-modifying reagents 5,5"-dithiobis-(2-nitrobenzoic acid) and iodoacetamide. Iodoacetamide 120-133 fatty acid synthase Gallus gallus 14-33 6362722-0 1983 Elementary steps in the reaction mechanism of chicken liver fatty acid synthase: reduced nicotinamide adenine dinucleotide phosphate binding and formation and reduction of acetoacetyl-enzyme. NADP 89-132 fatty acid synthase Gallus gallus 60-79 6362722-1 1983 The kinetics of reduced nicotinamide adenine dinucleotide phosphate (NADPH) binding to fatty acid synthase from chicken liver and of the reduction of enzyme-bound acetoacetyl by NADPH (beta-ketoacyl reductase) and the steps leading to formation of the acetoacetyl-enzyme have been studied in 0.1 M potassium phosphate-1 mM ethylenediaminetetraacetic acid (EDTA), pH 7.0, at 25 degrees C by monitoring changes in NADPH fluorescence with a stopped-flow apparatus. NADP 24-67 fatty acid synthase Gallus gallus 87-106 6362722-1 1983 The kinetics of reduced nicotinamide adenine dinucleotide phosphate (NADPH) binding to fatty acid synthase from chicken liver and of the reduction of enzyme-bound acetoacetyl by NADPH (beta-ketoacyl reductase) and the steps leading to formation of the acetoacetyl-enzyme have been studied in 0.1 M potassium phosphate-1 mM ethylenediaminetetraacetic acid (EDTA), pH 7.0, at 25 degrees C by monitoring changes in NADPH fluorescence with a stopped-flow apparatus. NADP 69-74 fatty acid synthase Gallus gallus 87-106 6871180-1 1983 The covalent modification of chicken liver fatty acid synthase by 4-(1-pyrenyl)butyryl-CoA (PBA-CoA), a fluorescent analogue of acetyl- and malonyl-CoA, has been studied. 4-(1-pyrenyl)butyryl-coa 66-90 fatty acid synthase Gallus gallus 43-62 6871180-1 1983 The covalent modification of chicken liver fatty acid synthase by 4-(1-pyrenyl)butyryl-CoA (PBA-CoA), a fluorescent analogue of acetyl- and malonyl-CoA, has been studied. pba-coa 92-99 fatty acid synthase Gallus gallus 43-62 6871180-1 1983 The covalent modification of chicken liver fatty acid synthase by 4-(1-pyrenyl)butyryl-CoA (PBA-CoA), a fluorescent analogue of acetyl- and malonyl-CoA, has been studied. acetyl- and malonyl-coa 128-151 fatty acid synthase Gallus gallus 43-62 6871181-1 1983 The kinetics of the reaction of acetyl coenzyme A (AcCoA) with fatty acid synthase has been studied with a modified quenched-flow technique in 0.1 M potassium phosphate (pH 7.0), 0.5 mM ethylenediaminetetraacetic acid, and 10% glycerol (w/v) at 23 degrees C. The kinetics of the deacetylation of the isolated acetylated enzyme by CoA also was studied. potassium phosphate 149-168 fatty acid synthase Gallus gallus 63-82 6871181-1 1983 The kinetics of the reaction of acetyl coenzyme A (AcCoA) with fatty acid synthase has been studied with a modified quenched-flow technique in 0.1 M potassium phosphate (pH 7.0), 0.5 mM ethylenediaminetetraacetic acid, and 10% glycerol (w/v) at 23 degrees C. The kinetics of the deacetylation of the isolated acetylated enzyme by CoA also was studied. Edetic Acid 186-217 fatty acid synthase Gallus gallus 63-82 6871181-1 1983 The kinetics of the reaction of acetyl coenzyme A (AcCoA) with fatty acid synthase has been studied with a modified quenched-flow technique in 0.1 M potassium phosphate (pH 7.0), 0.5 mM ethylenediaminetetraacetic acid, and 10% glycerol (w/v) at 23 degrees C. The kinetics of the deacetylation of the isolated acetylated enzyme by CoA also was studied. Glycerol 227-235 fatty acid synthase Gallus gallus 63-82 33658091-7 2022 CLA treatment increased the incorporation of both CLA isomers (c9t11 and t10c12) in liver of chick offspring, accompanied by the decreased hepatic TG levels, related to the significant reduction of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) enzyme activities and the increased of carnitine palmitoyltransferase-1 (CPT1) enzyme activity. Linoleic Acids, Conjugated 0-3 fatty acid synthase Gallus gallus 198-217 7104298-0 1982 Investigation of reduced nicotinamide adenine dinucleotide phosphate and acyl-binding sites on avian fatty acid synthase. NADP 25-68 fatty acid synthase Gallus gallus 101-120 7104298-1 1982 The binding of reduced nicotinamide adenine dinucleotide phosphate (NADPH) to chicken liver fatty acid synthase has been studied by using both fluorescence titrations and the direct binding method of forced dialysis. NADP 23-66 fatty acid synthase Gallus gallus 92-111 7104298-1 1982 The binding of reduced nicotinamide adenine dinucleotide phosphate (NADPH) to chicken liver fatty acid synthase has been studied by using both fluorescence titrations and the direct binding method of forced dialysis. NADP 68-73 fatty acid synthase Gallus gallus 92-111 33658091-8 2022 Meanwhile, CLA treatment reduced the mRNA expression of genes related to fatty acid biosynthesis (FAS, ACC, and sterol regulatory element-binding protein-1c), and induced the expression of genes related to beta-oxidative (CPT1, AMP-activated protein kinase, and peroxisome proliferator-activated receptor alpha) in chick offspring liver. Linoleic Acids, Conjugated 11-14 fatty acid synthase Gallus gallus 98-101 33658091-7 2022 CLA treatment increased the incorporation of both CLA isomers (c9t11 and t10c12) in liver of chick offspring, accompanied by the decreased hepatic TG levels, related to the significant reduction of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) enzyme activities and the increased of carnitine palmitoyltransferase-1 (CPT1) enzyme activity. Linoleic Acids, Conjugated 0-3 fatty acid synthase Gallus gallus 219-222 33357687-8 2021 Genistein increased estrogen receptor beta (ERbeta), forkhead box O1, nicotinamide phosphoribosyl transferase, sirtuin1 (SIRT1), phospho (p)-adenosine 5"-monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha), p-ACC, and CPT-I protein levels, whereas the SREBP-1c and FAS levels were decreased. Genistein 0-9 fatty acid synthase Gallus gallus 341-344 33152222-8 2021 Lycopene increased the mRNA abundance of adenosine monophosphate activated protein kinase alpha (AMPK-alpha), whereas decreased the mRNA abundance of sterol regulatory element-binding protein 1, FAS and ACC compared to the control group (p<0.05). Lycopene 0-8 fatty acid synthase Gallus gallus 195-198 33519285-6 2021 Further, the key regulators of lipid metabolism, including fatty acid synthase, acetyl-CoA carboxylase alpha, and acyl-CoA synthetase long-chain family member 1, demonstrated decreased expression following vitamin E supplementation. Vitamin E 206-215 fatty acid synthase Gallus gallus 59-78 31106428-4 2019 In addition, dietary taurine supplementation also significantly decreased the levels of triglyceride, acyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), and suppressed the mRNA expression levels of liver X receptor alpha (LXRalpha), sterol response element-binding protein 1c, ACC and FAS in the liver of chronic heat-stressed broilers. Taurine 21-28 fatty acid synthase Gallus gallus 133-152 31376347-3 2019 Hepatic TG, TCH levels, and fatty acid synthase activity were also decreased (P < 0.05) in chickens fed diets containing perilla oil. perilla seed oil 121-132 fatty acid synthase Gallus gallus 28-47 31106428-4 2019 In addition, dietary taurine supplementation also significantly decreased the levels of triglyceride, acyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), and suppressed the mRNA expression levels of liver X receptor alpha (LXRalpha), sterol response element-binding protein 1c, ACC and FAS in the liver of chronic heat-stressed broilers. Taurine 21-28 fatty acid synthase Gallus gallus 154-157 31106428-4 2019 In addition, dietary taurine supplementation also significantly decreased the levels of triglyceride, acyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), and suppressed the mRNA expression levels of liver X receptor alpha (LXRalpha), sterol response element-binding protein 1c, ACC and FAS in the liver of chronic heat-stressed broilers. Taurine 21-28 fatty acid synthase Gallus gallus 292-295 30406489-6 2019 Treatment with V alone upregulated the expression of hepatic fatty acid synthase (FAS) and sterol-regulator element-binding protein 1 (SREBP1), while EGCG downregulated FAS and SREBP1 expressions in contrast to V10 treatments (P < 0.01). epigallocatechin gallate 150-154 fatty acid synthase Gallus gallus 169-172 30406489-8 2019 In conclusion, the data gathered in this study indicate that dietary V and EGCG alter the layers" lipid metabolism and fat deposition pattern in egg yolk, which might be associated with their modulatory effect on lipogenesis-related gene (FAS, SREBP1, and PPARgamma) expression. epigallocatechin gallate 75-79 fatty acid synthase Gallus gallus 239-242 30053224-8 2019 The gene expression levels of fatty acid synthase (FAS) and sterol regulatory element binding protein-1c (SREBP-1c) were significantly decreased in all curcumin groups (P < 0.05), but the gene expression levels of acetyl CoA carboxylase (ACC) and ATP-citrate lyase (ACLY) were significantly decreased only in the 2,000 mg/kg curcumin group (P < 0.05). Curcumin 152-160 fatty acid synthase Gallus gallus 30-49 30987204-12 2019 This is further supported by evidence that the FOXO3-regulated histone deacetylase (HDAC2) was found to recognize the FASN (involved in fatty acid synthesis) chicken promoter in a yeast one-hybrid assay. Fatty Acids 136-146 fatty acid synthase Gallus gallus 118-122 30827101-3 2019 The current results showed that (-)-HCA decreased the accumulation of lipid droplets and triglyceride content by reducing fatty acid synthase protein level and enhancing phosphorylation of acetyl-CoA carboxylase protein level. hydroxycitric acid 32-39 fatty acid synthase Gallus gallus 122-141 30053224-8 2019 The gene expression levels of fatty acid synthase (FAS) and sterol regulatory element binding protein-1c (SREBP-1c) were significantly decreased in all curcumin groups (P < 0.05), but the gene expression levels of acetyl CoA carboxylase (ACC) and ATP-citrate lyase (ACLY) were significantly decreased only in the 2,000 mg/kg curcumin group (P < 0.05). Curcumin 152-160 fatty acid synthase Gallus gallus 51-54 30053224-10 2019 These results indicated that curcumin plays an important role in reduction abdominal fat deposition by decreasing the hepatic and plasma lipid profile and affecting the expression levels of genes related to lipogenesis and lipolysis including ACC, FAS, SREBP-1c, ACLY, PPARalpha, and CPT-I. Curcumin 29-37 fatty acid synthase Gallus gallus 248-251 30103743-5 2018 A highly significant down-regulation of genes involved in hepatic lipogenesis including acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), malic enzyme (ME), and lipoprotein lipase (LPL) was observed in the liver of chickens fed MC. Methylcholanthrene 235-237 fatty acid synthase Gallus gallus 118-137 30405443-10 2018 These results indicated that dietary GEN downregulated the expression of genes related to fatty acid synthesis [sterol regulatory element-binding protein 1 (SREBP1c), liver X receptor alpha (LXRalpha), fatty acid synthase (FAS), and acetyl coenzyme A synthetase (ACC)] and the fatty acid transporter (FAT). Fatty Acids 90-100 fatty acid synthase Gallus gallus 202-221 29173220-0 2017 Manganese influences the expression of fatty acid synthase and malic enzyme in cultured primary chicken hepatocytes. Manganese 0-9 fatty acid synthase Gallus gallus 39-58 29230177-12 2017 Treatment with quercetin, one bioactive ingredient in Noni, up-regulated the expression of ACCalpha, FASN, and ACLY under TN conditions, but it appeared to down-regulate ACCalpha and increase ACLY levels under HS exposure. Quercetin 15-24 fatty acid synthase Gallus gallus 101-105 26707345-6 2016 Additionally, the enzymatic activity of fatty acid synthase was lower in the liver of the clenbuterol-injected chicks. Clenbuterol 90-101 fatty acid synthase Gallus gallus 40-59 28954258-4 2017 ATP-citrate lyase, fatty acid synthase and sterol regulatory element binding protein-1c mRNA level were significantly decreased after (-)-HCA treatment, whereas peroxisome proliferator-activated receptor alpha mRNA level was significantly increased. hydroxycitric acid 134-141 fatty acid synthase Gallus gallus 19-38 28194404-5 2017 As for the enzyme indexes, a selenium effect is only detected for thioesterase. Selenium 29-37 fatty acid synthase Gallus gallus 66-78 25036958-5 2014 Additionally, point mutagenesis analysis showed that the substitution of Asp by Gly within the Pro-Val-Asp-Leu-Thr (PVDLT) motif of gKLF3 significantly reduced the ability of gKLF3 to regulate the promoter activities of FABP4, FASN, LPL, C/EBPalpha, and PPARgamma. Aspartic Acid 73-76 fatty acid synthase Gallus gallus 227-231 25521589-7 2015 Simultaneously, the activities of hepatic fatty acid synthesis enzymes (fatty acid synthase and acetyl CoA carboxylase) were significantly decreased, and the activity of carnitine palmitoyl transferase-1 was notably elevated. hepatic fatty acid 34-52 fatty acid synthase Gallus gallus 72-91 26693219-3 2015 We observed that PPARalpha agonist clofibrate decreases the mRNA and protein levels of LXRalpha and the mRNA and both precursor and nuclear protein levels of SREBP1 and SREBP2 as well as the mRNA levels of the SREBP1 (FASN and GPAM) and SREBP2 (HMGCR and LDLR) target genes in the liver of treated broiler chickens compared to control group, whereas the mRNA level of INSIG2, which inhibits SREBP activation, was increased in the liver of treated broiler chickens compared to control group. Clofibrate 35-45 fatty acid synthase Gallus gallus 218-222 25037819-6 2014 Folate caused a dose-dependent decrease in transcript abundance of peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha) gene expression, and the downstream enzyme fatty acid synthase; in contrast, expression of DNA (cytosine-5)-methyltransferase and methylenetetrahydrofolate reductase was obviously upregulated at d 6 of differentiation (P < 0.05). Folic Acid 0-6 fatty acid synthase Gallus gallus 222-241 23889082-8 2014 Rosiglitazone significantly increased the expression levels of adipose triglyceride lipase (ATGL) and AdipoR1 and decreased the expression levels of fatty acid synthase (FAS). Rosiglitazone 0-13 fatty acid synthase Gallus gallus 149-168 23889082-8 2014 Rosiglitazone significantly increased the expression levels of adipose triglyceride lipase (ATGL) and AdipoR1 and decreased the expression levels of fatty acid synthase (FAS). Rosiglitazone 0-13 fatty acid synthase Gallus gallus 170-173 25036958-5 2014 Additionally, point mutagenesis analysis showed that the substitution of Asp by Gly within the Pro-Val-Asp-Leu-Thr (PVDLT) motif of gKLF3 significantly reduced the ability of gKLF3 to regulate the promoter activities of FABP4, FASN, LPL, C/EBPalpha, and PPARgamma. Glycine 80-83 fatty acid synthase Gallus gallus 227-231 25036958-5 2014 Additionally, point mutagenesis analysis showed that the substitution of Asp by Gly within the Pro-Val-Asp-Leu-Thr (PVDLT) motif of gKLF3 significantly reduced the ability of gKLF3 to regulate the promoter activities of FABP4, FASN, LPL, C/EBPalpha, and PPARgamma. Pro-Val-Asp-Leu-Thr 95-114 fatty acid synthase Gallus gallus 227-231 23472611-6 2013 However, chickens supplemented with L-Arg had lower abdominal fat content, plasma triglyceride (TG), total cholesterol (TC) concentrations, hepatic FAS mRNA expression and increased heart carnitine palmitoyl transferase1 (CPT1) and 3-hydroxyacyl-CoA dehydrogenase (3HADH) mRNA expression. Arginine 36-41 fatty acid synthase Gallus gallus 148-151 19903962-2 2009 Liver X receptor alpha directly regulates both the expression of other lipogenic transcription factors and the expression of lipogenic enzymes, thereby enhancing hepatic fatty acid synthesis (FASN). hepatic fatty acid 162-180 fatty acid synthase Gallus gallus 192-196 21294661-6 2011 In fasted chickens, DEX treatment significantly (P < 0.01) upregulated the hepatic mRNA levels of acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS). Dextromethorphan 20-23 fatty acid synthase Gallus gallus 134-153 21294661-6 2011 In fasted chickens, DEX treatment significantly (P < 0.01) upregulated the hepatic mRNA levels of acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS). Dextromethorphan 20-23 fatty acid synthase Gallus gallus 155-158 21294661-8 2011 In cultured primary hepatocytes, combined DEX and insulin significantly upregulated the transcription of the genes for FAS (1.34-fold) and malic enzyme (1.72-fold). Dextromethorphan 42-45 fatty acid synthase Gallus gallus 119-122 20845073-6 2011 After adding 0.1% betaine to diet, the mRNA levels of fatty acid synthase (FAS) and adipocyte-type fatty acid-binding protein genes in abdominal adipose were significantly decreased in 56-day-old broilers, and those of LPL and FAS genes in abdominal adipose were significantly decreased in 66-day-old broilers comparing with the control group (P < 0.05 and P < 0.001). Betaine 18-25 fatty acid synthase Gallus gallus 54-73 20845073-6 2011 After adding 0.1% betaine to diet, the mRNA levels of fatty acid synthase (FAS) and adipocyte-type fatty acid-binding protein genes in abdominal adipose were significantly decreased in 56-day-old broilers, and those of LPL and FAS genes in abdominal adipose were significantly decreased in 66-day-old broilers comparing with the control group (P < 0.05 and P < 0.001). Betaine 18-25 fatty acid synthase Gallus gallus 75-78 20845073-6 2011 After adding 0.1% betaine to diet, the mRNA levels of fatty acid synthase (FAS) and adipocyte-type fatty acid-binding protein genes in abdominal adipose were significantly decreased in 56-day-old broilers, and those of LPL and FAS genes in abdominal adipose were significantly decreased in 66-day-old broilers comparing with the control group (P < 0.05 and P < 0.001). Betaine 18-25 fatty acid synthase Gallus gallus 227-230 20845073-6 2011 After adding 0.1% betaine to diet, the mRNA levels of fatty acid synthase (FAS) and adipocyte-type fatty acid-binding protein genes in abdominal adipose were significantly decreased in 56-day-old broilers, and those of LPL and FAS genes in abdominal adipose were significantly decreased in 66-day-old broilers comparing with the control group (P < 0.05 and P < 0.001). Fatty Acids 54-64 fatty acid synthase Gallus gallus 75-78 20060923-8 2010 However, blood TC, and hepatic fatty acid synthase (FAS) and hydroxy methylglutaryl-CoA reductase (HMGR) gene expression were significantly up-regulated in the 100mg DHEA/kg group during embryonic development and hatching. Dehydroepiandrosterone 166-170 fatty acid synthase Gallus gallus 31-50 20060923-8 2010 However, blood TC, and hepatic fatty acid synthase (FAS) and hydroxy methylglutaryl-CoA reductase (HMGR) gene expression were significantly up-regulated in the 100mg DHEA/kg group during embryonic development and hatching. Dehydroepiandrosterone 166-170 fatty acid synthase Gallus gallus 52-55