PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23840713-7	2013	The oxidation of glucose to CO2 and incorporation of glucose-carbon into fatty acids were reduced in brain slices from 15 day-old PDC-deficient females.	Glucose	17-24	phosducin	Mus musculus	130-133
33127821-5	2020	Genetic disruption of Hvcn1, which encodes Hv1, impaired mouse pDC activation by CpG oligonucleotides in vitro and in vivo, reducing IFN-alpha secretion and the induction of IFN-stimulated genes.	CPG-oligonucleotide	81-101	phosducin	Mus musculus	63-66
30840833-9	2019	Moreover, although absence of SphK2 increased pDC frequency in pristane-induced lupus, there were no major changes in their activation status.	pristane	63-71	phosducin	Mus musculus	46-49
23840713-7	2013	The oxidation of glucose to CO2 and incorporation of glucose-carbon into fatty acids were reduced in brain slices from 15 day-old PDC-deficient females.	Carbon	61-67	phosducin	Mus musculus	130-133
23840713-7	2013	The oxidation of glucose to CO2 and incorporation of glucose-carbon into fatty acids were reduced in brain slices from 15 day-old PDC-deficient females.	Fatty Acids	73-84	phosducin	Mus musculus	130-133
23840713-12	2013	CONCLUSIONS: The results show that a reduction in glucose metabolism resulting in deficit in energy production and fatty acid biosynthesis impairs cellular differentiation and brain development in PDC-deficient mice.	Glucose	50-57	phosducin	Mus musculus	197-200
23840713-12	2013	CONCLUSIONS: The results show that a reduction in glucose metabolism resulting in deficit in energy production and fatty acid biosynthesis impairs cellular differentiation and brain development in PDC-deficient mice.	Fatty Acids	115-125	phosducin	Mus musculus	197-200
33913468-18	2022	Broad spectrum-PHD inhibitors, e.g. Roxadustat, are currently being prescribed to chronic kidney disease patients, who are already at risk for cardiovascular disease.	roxadustat	36-46	phosducin	Mus musculus	15-18
23840713-7	2013	The oxidation of glucose to CO2 and incorporation of glucose-carbon into fatty acids were reduced in brain slices from 15 day-old PDC-deficient females.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	28-31	phosducin	Mus musculus	130-133
23840713-7	2013	The oxidation of glucose to CO2 and incorporation of glucose-carbon into fatty acids were reduced in brain slices from 15 day-old PDC-deficient females.	Glucose	53-60	phosducin	Mus musculus	130-133
19959875-5	2009	Isolated postganglionic sympathetic neurons from Pdc-/- mice showed prolonged action potential firing after stimulation with acetylcholine and increased firing frequencies during membrane depolarization.	Acetylcholine	125-138	phosducin	Mus musculus	49-60
22911908-5	2012	When transplanted on a collagen-calcium phosphate scaffold in vivo, mPDC attracted numerous blood vessels and formed mature bone which comprises a hematopoiesis-supportive stroma.	collagen-calcium phosphate	23-49	phosducin	Mus musculus	68-72
10443588-6	1999	The opioid receptors present in the cell membrane internalize upon etorphine (1 nM) exposure, a process clearly blocked in cells overexpressing phosducin.	Etorphine	67-76	phosducin	Mus musculus	144-153
19959875-4	2009	Mice with a targeted deletion of the gene encoding Pdc (Pdc-/- mice) had increased blood pressure despite normal cardiac function and vascular reactivity, and displayed elevated catecholamine turnover in the peripheral sympathetic system.	Catecholamines	178-191	phosducin	Mus musculus	51-54
19959875-4	2009	Mice with a targeted deletion of the gene encoding Pdc (Pdc-/- mice) had increased blood pressure despite normal cardiac function and vascular reactivity, and displayed elevated catecholamine turnover in the peripheral sympathetic system.	Catecholamines	178-191	phosducin	Mus musculus	56-67
34453973-8	2022	The intra-LHb administration of PDC (0.5 ng) worsened the effect of ethanol withdrawal, whereas Ro25-6981 (2 and 4 ng) and BAPTA-AM (6.5 and 13 ng) significantly reversed ethanol withdrawal-induced behavior evident by a decrease in somatic signs, locomotor activity, and anxiety-like behavior.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	10-13	phosducin	Mus musculus	32-35
9496706-0	1998	Phosducin expression in NG 108-15 hybrid cells enhances prostaglandin E1 stimulated adenylate cyclase activity.	Alprostadil	56-72	phosducin	Mus musculus	0-9
9496706-2	1998	These suggestions together with the enhancing effect of Phd on odorant-induced cAMP accumulation let us assume a stimulatory action of the protein on intracellular signaling.	Cyclic AMP	79-83	phosducin	Mus musculus	56-59
9496706-4	1998	The neuronal cells stably expressing Phd were found to display a 3 to 4-fold increased sensitivity to PGE1 as compared to wild type cells, using cAMP accumulation as measure.	Alprostadil	102-106	phosducin	Mus musculus	37-40
9496706-4	1998	The neuronal cells stably expressing Phd were found to display a 3 to 4-fold increased sensitivity to PGE1 as compared to wild type cells, using cAMP accumulation as measure.	Cyclic AMP	145-149	phosducin	Mus musculus	37-40
9496706-5	1998	Examination of membranes prepared from Phd-overexpressing cells revealed an elevated GTPase activity as indicated by the formation of 32Pi upon PGE1 challenge.	Alprostadil	144-148	phosducin	Mus musculus	39-42
9496706-7	1998	In addition, receptor independent stimulation of adenylate cyclase by forskolin reveals an increased formation of cAMP in Phd expressing cells, which is accompanied by an increased binding of [3H]forskolin.	Colforsin	70-79	phosducin	Mus musculus	122-125
9496706-7	1998	In addition, receptor independent stimulation of adenylate cyclase by forskolin reveals an increased formation of cAMP in Phd expressing cells, which is accompanied by an increased binding of [3H]forskolin.	Cyclic AMP	114-118	phosducin	Mus musculus	122-125
9496706-7	1998	In addition, receptor independent stimulation of adenylate cyclase by forskolin reveals an increased formation of cAMP in Phd expressing cells, which is accompanied by an increased binding of [3H]forskolin.	Tritium	193-195	phosducin	Mus musculus	122-125
9496706-7	1998	In addition, receptor independent stimulation of adenylate cyclase by forskolin reveals an increased formation of cAMP in Phd expressing cells, which is accompanied by an increased binding of [3H]forskolin.	Colforsin	196-205	phosducin	Mus musculus	122-125
9496706-8	1998	The findings let us propose that Phd elevates intracellular levels of functional G alpha s which accounts for the increased response to PGE1.	Alprostadil	136-140	phosducin	Mus musculus	33-36
10087055-4	1999	Studying the binding of [35S]guanosine-5"-O-(gamma-thio)-triphosphate to membranes from Phd overexpressing cells, we found that [D-penicillamine2, D-penicillamine5 ]enkephalin failed, in the presence of Phd (0.1 nM), to elevate incorporation of the nucleotide.	[35s]guanosine-5"-o-(gamma-thio)-triphosphate	24-69	phosducin	Mus musculus	88-91
10087055-4	1999	Studying the binding of [35S]guanosine-5"-O-(gamma-thio)-triphosphate to membranes from Phd overexpressing cells, we found that [D-penicillamine2, D-penicillamine5 ]enkephalin failed, in the presence of Phd (0.1 nM), to elevate incorporation of the nucleotide.	[d-penicillamine2	128-145	phosducin	Mus musculus	88-91
10087055-4	1999	Studying the binding of [35S]guanosine-5"-O-(gamma-thio)-triphosphate to membranes from Phd overexpressing cells, we found that [D-penicillamine2, D-penicillamine5 ]enkephalin failed, in the presence of Phd (0.1 nM), to elevate incorporation of the nucleotide.	[d-penicillamine2	128-145	phosducin	Mus musculus	203-206
10087055-4	1999	Studying the binding of [35S]guanosine-5"-O-(gamma-thio)-triphosphate to membranes from Phd overexpressing cells, we found that [D-penicillamine2, D-penicillamine5 ]enkephalin failed, in the presence of Phd (0.1 nM), to elevate incorporation of the nucleotide.	d-penicillamine5 ]enkephalin	147-175	phosducin	Mus musculus	88-91
10087055-11	1999	Thus, in Phd overexpressing cells, opioids exhibit an increased efficacy despite the inhibitory action of the phosphoprotein on opioid-stimulated incorporation of [35S]guanosine-5"-O-(gamma-thio)-triphosphate.	guanosine-5"-o-(gamma-thio)-triphosphate	168-208	phosducin	Mus musculus	9-12
9593987-4	1998	We made use of enhanced green fluorescence protein (EGFP), a reporter protein, to follow redistribution of Phd both by means of confocal microscopy and biochemical techniques in living neuronal NG 108-15 hybrid cells challenged with prostaglandin E1 (PGE1).	Alprostadil	233-249	phosducin	Mus musculus	107-110
9593987-4	1998	We made use of enhanced green fluorescence protein (EGFP), a reporter protein, to follow redistribution of Phd both by means of confocal microscopy and biochemical techniques in living neuronal NG 108-15 hybrid cells challenged with prostaglandin E1 (PGE1).	Alprostadil	251-255	phosducin	Mus musculus	107-110
9593987-6	1998	Overexpression of the proteins is implied by FACS analysis as well as by western blot technique, and the functional integrity of EGFP-tagged Phd was confirmed by its ability to elevate cAMP accumulation.	Cyclic AMP	185-189	phosducin	Mus musculus	141-144
9593987-7	1998	Time-lapse imaging of single living cells by means of confocal microscopy revealed that exposure to prostaglandin causes EGFP/Phd, which is evenly spread throughout the cell, to relocate towards the membrane within few minutes.	Prostaglandins	100-113	phosducin	Mus musculus	126-129
9593987-9	1998	The principle finding that prostaglandin triggers translocation of Phd from cytosol to the cell periphery was verified with membranes prepared from EGFP/Phd expressing cells.	Prostaglandins	27-40	phosducin	Mus musculus	67-70
9593987-9	1998	The principle finding that prostaglandin triggers translocation of Phd from cytosol to the cell periphery was verified with membranes prepared from EGFP/Phd expressing cells.	Prostaglandins	27-40	phosducin	Mus musculus	153-156
9593987-11	1998	The present study reports for living NG 108-15 hybrid cells that PGE1 stimulation causes cytosolic Phd to translocate towards the membrane, where it is believed to bind to G protein subunits such as Gbetagamma and Galphas.	Alprostadil	65-69	phosducin	Mus musculus	99-102
34453973-8	2022	The intra-LHb administration of PDC (0.5 ng) worsened the effect of ethanol withdrawal, whereas Ro25-6981 (2 and 4 ng) and BAPTA-AM (6.5 and 13 ng) significantly reversed ethanol withdrawal-induced behavior evident by a decrease in somatic signs, locomotor activity, and anxiety-like behavior.	Ethanol	68-75	phosducin	Mus musculus	32-35