PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31138526-5	2019	Spatial activation of p53 target genes in response to bortezomib in the small intestine demonstrated that CDKN1A and BAX were upregulated in the proliferative crypts but not in the differentiated villi of the small intestine; PUMA was specifically activated at the crypt base of p53 wild-type mice.	Bortezomib	54-64	BCL2 binding component 3	Mus musculus	226-230
30552702-0	2019	p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice.	Acetaminophen	59-72	BCL2 binding component 3	Mus musculus	0-39
30864841-7	2019	Paricalcitol ameliorated body weight loss, attenuated serum blood urea nitrogen and creatinine accumulation, blocked tubular cell apoptosis, prevented the suppression of Bcl-2, and reversed PUMA and miR-155 induction and caspase-3 activation in LPS-treated WT mice.	paricalcitol	0-12	BCL2 binding component 3	Mus musculus	190-194
30864841-8	2019	In HK2 cells, LPS induced PUMA and miR-155 by activating NF-kappaB, whereas 1,25(OH)2D3 blocked PUMA and miR-155 induction by repressing NF-kappaB activation.	(oh)2d3	80-87	BCL2 binding component 3	Mus musculus	96-100
30864841-10	2019	Collectively, these data provide strong evidence that LPS induces tubular cell apoptosis via upregulating PUMA and miR-155, whereas vitamin D/VDR signaling protects against AKI by blocking NF-kappaB-mediated PUMA and miR-155 upregulation.	Deuterium	140-141	BCL2 binding component 3	Mus musculus	208-212
30552702-5	2019	PUMA deficiency suppressed APAP-induced mitochondrial dysfunction and release of cell death factors from mitochondria, and protected against APAP-induced hepatocyte necrosis and liver injury in mice.	Acetaminophen	27-31	BCL2 binding component 3	Mus musculus	0-4
30552702-5	2019	PUMA deficiency suppressed APAP-induced mitochondrial dysfunction and release of cell death factors from mitochondria, and protected against APAP-induced hepatocyte necrosis and liver injury in mice.	Acetaminophen	141-145	BCL2 binding component 3	Mus musculus	0-4
30552702-7	2019	Furthermore, a small-molecule PUMA inhibitor, administered after APAP treatment, mitigated APAP-induced hepatocyte necrosis and liver injury.	Acetaminophen	65-69	BCL2 binding component 3	Mus musculus	30-34
30552702-7	2019	Furthermore, a small-molecule PUMA inhibitor, administered after APAP treatment, mitigated APAP-induced hepatocyte necrosis and liver injury.	Acetaminophen	91-95	BCL2 binding component 3	Mus musculus	30-34
30552702-8	2019	Conclusion: Our results demonstrate that RIP1/JNK-dependent PUMA induction mediates AILI by promoting hepatocyte mitochondrial dysfunction and necrosis, and suggest that PUMA inhibition is useful for alleviating acute hepatotoxicity attributed to APAP overdose.	Acetaminophen	247-251	BCL2 binding component 3	Mus musculus	60-64
30552702-8	2019	Conclusion: Our results demonstrate that RIP1/JNK-dependent PUMA induction mediates AILI by promoting hepatocyte mitochondrial dysfunction and necrosis, and suggest that PUMA inhibition is useful for alleviating acute hepatotoxicity attributed to APAP overdose.	Acetaminophen	247-251	BCL2 binding component 3	Mus musculus	170-174
29781855-10	2018	In addition, systemic AMD3100 increased local provasculogenic factors (hypoxia-inducible factor 1 alpha, stromal cell-derived factor 1 alpha, and vascular endothelial growth factor; P <= 0.05) and decreased local proapoptotic factors (p53, PUMA, and Bax; P <= 0.05).	plerixafor	22-29	BCL2 binding component 3	Mus musculus	240-244
20546728-9	2010	Our study provides the evidence that polyglutamine-expanded ataxin-7 upregulates the expression of Bax and Puma and causes apoptotic neuronal death by enhancing phosphorylation and transcriptional activity of p53.	polyglutamine	37-50	BCL2 binding component 3	Mus musculus	107-111
28277537-4	2017	We found that SiO2 induced increased BBC3 expression, as well as macrophage activation and apoptosis.	Silicon Dioxide	14-18	BCL2 binding component 3	Mus musculus	37-41
28277537-5	2017	Knockdown of Bbc3 with specific siRNA significantly mitigated the SiO2-induced effects.	Silicon Dioxide	66-70	BCL2 binding component 3	Mus musculus	13-17
27619562-7	2016	Instead, inhibition of Drp1 mitochondrial translocation diminished MPTP-induced p53, BAX and PUMA mitochondrial translocation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	67-71	BCL2 binding component 3	Mus musculus	93-97
25457551-8	2015	Notably, PUMA contributed to neuronal apoptosis through competitive binding of apoptosis repressor with caspase recruitment domain to activate caspase-8 that cleaved Bid into tBid to accelerate Bax mitochondrial translocation, revealing a novel pathway of Bax activation by PUMA to mediate Abeta-induced neuronal apoptosis.	tBID	175-179	BCL2 binding component 3	Mus musculus	9-13
29795372-6	2018	Interestingly, siFAM188B treatment induced the upregulation and activation of p53, and consequently increased p53-regulated pro-apoptotic proteins, PUMA and BAX.	sifam188b	15-24	BCL2 binding component 3	Mus musculus	148-152
28406729-3	2017	Lysates from mice injected with doxorubicin showed that Dmp1 bound to p21Cip1, Bbc3, and Thbs1 gene regulatory regions in a p53-dependent fashion.	Doxorubicin	32-43	BCL2 binding component 3	Mus musculus	79-83
27464000-0	2016	Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity.	Methamphetamine	112-127	BCL2 binding component 3	Mus musculus	7-11
27464000-5	2016	Moreover, anti-Mir143-dependent BBC3 upregulation reversed the methamphetamine-induced decrease in microglial survival via the regulation of apoptosis and autophagy.	Methamphetamine	63-78	BCL2 binding component 3	Mus musculus	32-36
27317935-5	2016	However, in DA-p53KO mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we found that the induction of Bax and p53 up-regulated modulator of apoptosis (PUMA) mRNA and protein levels by MPTP were diminished in both striatum and substantia nigra of these mice.	Dopamine	12-14	BCL2 binding component 3	Mus musculus	146-185
27317935-5	2016	However, in DA-p53KO mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we found that the induction of Bax and p53 up-regulated modulator of apoptosis (PUMA) mRNA and protein levels by MPTP were diminished in both striatum and substantia nigra of these mice.	Dopamine	12-14	BCL2 binding component 3	Mus musculus	187-191
27317935-5	2016	However, in DA-p53KO mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we found that the induction of Bax and p53 up-regulated modulator of apoptosis (PUMA) mRNA and protein levels by MPTP were diminished in both striatum and substantia nigra of these mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	54-98	BCL2 binding component 3	Mus musculus	146-185
27317935-5	2016	However, in DA-p53KO mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we found that the induction of Bax and p53 up-regulated modulator of apoptosis (PUMA) mRNA and protein levels by MPTP were diminished in both striatum and substantia nigra of these mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	54-98	BCL2 binding component 3	Mus musculus	187-191
27317935-5	2016	However, in DA-p53KO mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we found that the induction of Bax and p53 up-regulated modulator of apoptosis (PUMA) mRNA and protein levels by MPTP were diminished in both striatum and substantia nigra of these mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	100-104	BCL2 binding component 3	Mus musculus	146-185
27317935-5	2016	However, in DA-p53KO mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we found that the induction of Bax and p53 up-regulated modulator of apoptosis (PUMA) mRNA and protein levels by MPTP were diminished in both striatum and substantia nigra of these mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	100-104	BCL2 binding component 3	Mus musculus	187-191
27317935-5	2016	However, in DA-p53KO mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we found that the induction of Bax and p53 up-regulated modulator of apoptosis (PUMA) mRNA and protein levels by MPTP were diminished in both striatum and substantia nigra of these mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	220-224	BCL2 binding component 3	Mus musculus	146-185
27317935-9	2016	Our results further support the role of programmed cell death mediated by p53 in this animal model of PD and identify Bax, BAD and PUMA genes as downstream targets of p53 in modulating DA neuronal death in the in vivo MPTP-induced PD model.	Dopamine	185-187	BCL2 binding component 3	Mus musculus	131-135
27317935-9	2016	Our results further support the role of programmed cell death mediated by p53 in this animal model of PD and identify Bax, BAD and PUMA genes as downstream targets of p53 in modulating DA neuronal death in the in vivo MPTP-induced PD model.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	218-222	BCL2 binding component 3	Mus musculus	131-135
27317935-10	2016	We deleted p53 gene in dopaminergic neurons in late developmental stages and found that DA specific p53 deletion is protective in acute MPTP animal model possibly through blocking MPTP-induced BAX and PUMA up-regulation.	Dopamine	88-90	BCL2 binding component 3	Mus musculus	201-205
27317935-10	2016	We deleted p53 gene in dopaminergic neurons in late developmental stages and found that DA specific p53 deletion is protective in acute MPTP animal model possibly through blocking MPTP-induced BAX and PUMA up-regulation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	136-140	BCL2 binding component 3	Mus musculus	201-205
27317935-10	2016	We deleted p53 gene in dopaminergic neurons in late developmental stages and found that DA specific p53 deletion is protective in acute MPTP animal model possibly through blocking MPTP-induced BAX and PUMA up-regulation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	180-184	BCL2 binding component 3	Mus musculus	201-205
35465098-11	2022	In addition, the Akt-FoxO1-PUMA pathway may also be responsible for sevoflurane-induced apoptosis.	Sevoflurane	68-79	BCL2 binding component 3	Mus musculus	27-31
34958889-0	2022	Ovarian Toxicity Induced by Aluminum Chloride: Alteration of Cyp19a1, Pcna, Puma, and Map1lc3b genes Expression.	Aluminum Chloride	28-45	BCL2 binding component 3	Mus musculus	76-80
34105803-6	2021	In D-DT Tg irradiated mouse keratinocytes, the p53, PUMA, and Bax expression was lower than that in WT mice.	d-dt tg	3-10	BCL2 binding component 3	Mus musculus	52-56
35517788-8	2022	Unexpectedly, disulfiram treatment did not inhibit crypt cell apoptosis 4 h after radiation and the regeneration of crypts from PUMA-deficient mice after irradiation was also promoted by disulfiram.	Disulfiram	187-197	BCL2 binding component 3	Mus musculus	128-132
34289071-0	2021	Bbc3 loss enhances survival and protein clearance in neurons exposed to the organophosphate pesticide chlorpyrifos.	Organophosphates	76-91	BCL2 binding component 3	Mus musculus	0-4
34289071-0	2021	Bbc3 loss enhances survival and protein clearance in neurons exposed to the organophosphate pesticide chlorpyrifos.	Chlorpyrifos	102-114	BCL2 binding component 3	Mus musculus	0-4
34067444-8	2021	Of note, the protective property of NB-EPA against ischemic neuronal damage was dependent on suppression of the p53-PUMA pathway.	nb-epa	36-42	BCL2 binding component 3	Mus musculus	116-120
35567716-6	2022	RESULTS: The experiment resulted in the suppression of ER stress marker BiP and UPR pathway genes such as Perk, Ire1alpha, Chop and Puma which mediate cellular apoptosis indicating the protective effect of 1, 25-(OH)2D3 against neuronal ER stress.	Calcitriol	206-219	BCL2 binding component 3	Mus musculus	132-136
35465098-13	2022	Moreover, The Akt-FoxO1-PUMA pathway may mediate the developmental decreases in magnitude of both physiological and sevoflurane-induced apoptosis in neonatal mouse S1.	Sevoflurane	116-127	BCL2 binding component 3	Mus musculus	24-28
35259468-10	2022	In nude mice, Xanthohumol administration suppressed NSCLC xenograft tumor growth and increased PUMA expression in tumor tissues.	xanthohumol	14-25	BCL2 binding component 3	Mus musculus	95-99
35259468-11	2022	Briefly, our studies revealed a novel mechanism by which Xanthohumol exerted its anti-tumor activity in a PUMA-dependent manner in NSCLC cells.	xanthohumol	57-68	BCL2 binding component 3	Mus musculus	106-110
32584135-0	2020	Follicle Stimulating Hormone Inhibits the Expression of p53 Up-Regulated Modulator of Apoptosis Induced by Reactive Oxygen Species Through PI3K/Akt in Mouse Granulosa Cells.	Reactive Oxygen Species	107-130	BCL2 binding component 3	Mus musculus	56-95
35344814-4	2022	Metformin upregulated BAX activation with facilitation of BIM, BAD and PUMA; downregulated Bcl-2 and Bcl-xl, but did not affect Mcl-1.	Metformin	0-9	BCL2 binding component 3	Mus musculus	71-75
33864208-3	2021	This study investigated the induction of classical DSB repair pathways in the follicles of wild type (WT) and apoptosis-deficient Puma-/- mice in response to DSBs caused by the chemotherapy agent cisplatin.	Cisplatin	196-205	BCL2 binding component 3	Mus musculus	130-134
33864208-7	2021	RESULTS: Puma-/- mice retained 100% of follicles 24 h after cisplatin treatment.	Cisplatin	60-69	BCL2 binding component 3	Mus musculus	9-13
33864208-8	2021	Eight hours post-treatment, gammaH2AX immunofluorescence showed DSBs across follicular stages in Puma-/- mice; staining returned to control levels in PMFs within 5 days, suggesting repair of PMF oocytes in this window.	dsbs	64-68	BCL2 binding component 3	Mus musculus	97-101
33037137-7	2021	UCN-01, a kinase inhibitor/mitochondrial uncoupler that has been shown to lead to Puma-induced mitochondrial apoptosis and ATP synthase inhibitor Oligomycin demonstrated effectiveness against spheroids, while spheroids were refractory to cisplatin and paclitaxel.	Paclitaxel	252-262	BCL2 binding component 3	Mus musculus	82-86
32584135-5	2020	Therefore, we examined whether FSH inhibits the expression of p53 up-regulated modulator of apoptosis (PUMA) induced by reactive oxygen species (ROS) through phosphoinositide 3-kinase (PI3K) / protein kinase B (AKT) in mouse GCs.	Reactive Oxygen Species	120-143	BCL2 binding component 3	Mus musculus	62-101
32584135-5	2020	Therefore, we examined whether FSH inhibits the expression of p53 up-regulated modulator of apoptosis (PUMA) induced by reactive oxygen species (ROS) through phosphoinositide 3-kinase (PI3K) / protein kinase B (AKT) in mouse GCs.	Reactive Oxygen Species	120-143	BCL2 binding component 3	Mus musculus	103-107
32584135-5	2020	Therefore, we examined whether FSH inhibits the expression of p53 up-regulated modulator of apoptosis (PUMA) induced by reactive oxygen species (ROS) through phosphoinositide 3-kinase (PI3K) / protein kinase B (AKT) in mouse GCs.	Reactive Oxygen Species	145-148	BCL2 binding component 3	Mus musculus	62-101
32584135-5	2020	Therefore, we examined whether FSH inhibits the expression of p53 up-regulated modulator of apoptosis (PUMA) induced by reactive oxygen species (ROS) through phosphoinositide 3-kinase (PI3K) / protein kinase B (AKT) in mouse GCs.	Reactive Oxygen Species	145-148	BCL2 binding component 3	Mus musculus	103-107
32584135-7	2020	We found that FSH can inhibit the 3-nitropropionic acid (3-NP) induced apoptosis and PUMA expression in mRNA level.	3-nitropropionic acid	57-61	BCL2 binding component 3	Mus musculus	85-89
32584135-8	2020	Moreover, In vitro experiment, we found that FSH can inhibit the H2O2-induced apoptosis and PUMA expression in mRNA level.	Hydrogen Peroxide	65-69	BCL2 binding component 3	Mus musculus	92-96
32584135-9	2020	Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	BCL2 binding component 3	Mus musculus	93-97
32584135-9	2020	Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	BCL2 binding component 3	Mus musculus	165-169
32584135-9	2020	Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro.	Reactive Oxygen Species	181-184	BCL2 binding component 3	Mus musculus	93-97
32584135-9	2020	Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro.	Reactive Oxygen Species	181-184	BCL2 binding component 3	Mus musculus	165-169
32454054-6	2020	It was found that STZ treatment induced apoptotic and pyroptotic cell death in the hippocampus as evidenced by increases of cleaved caspase 3 positive hippocampal neurons, TUNEL-positive cells, protein levels of p53, Bax, Puma, and the cleaved GSDMD N-terminal fragment, all of which were decreased in NLRP3 deficient mice.	Streptozocin	18-21	BCL2 binding component 3	Mus musculus	222-226
32450188-0	2020	Knockdown of circHomer1 ameliorates METH-induced neuronal injury through inhibiting Bbc3 expression.	Methamphetamine	36-40	BCL2 binding component 3	Mus musculus	84-88
32450188-8	2020	Besides, suppression of Bbc3 decreased the reactive oxygen species (ROS) level and radio of PI-positive cells.	Reactive Oxygen Species	43-66	BCL2 binding component 3	Mus musculus	24-28
32450188-8	2020	Besides, suppression of Bbc3 decreased the reactive oxygen species (ROS) level and radio of PI-positive cells.	Reactive Oxygen Species	68-71	BCL2 binding component 3	Mus musculus	24-28
32450188-9	2020	Furthermore, we analyzed the correlation in pairs among circHomer1, Bbc3 and behaviors in well-developed METH-addicted models using Pearson"s correlation coefficient, which implied an important role of circHomer1 and Bbc3 in addictive behaviors.	Methamphetamine	105-109	BCL2 binding component 3	Mus musculus	68-72
32450188-9	2020	Furthermore, we analyzed the correlation in pairs among circHomer1, Bbc3 and behaviors in well-developed METH-addicted models using Pearson"s correlation coefficient, which implied an important role of circHomer1 and Bbc3 in addictive behaviors.	Methamphetamine	105-109	BCL2 binding component 3	Mus musculus	217-221
32450188-10	2020	In all, we for the first time identified a novel circRNA, circHomer1 and our results suggested that circHomer1 regulated METH-induced lethal process by suppressing the Bbc3 expression.	Methamphetamine	121-125	BCL2 binding component 3	Mus musculus	168-172