PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 27810232-4 2017 OBJECTIVE: To investigate which subsets of IL-17-producing cells are involved in psoriasis-like skin inflammation in a TPA (tumor promoter 12-O-tetradecanoylphorbol-13-acetate)-induced K14.Stat3C mouse model. Tetradecanoylphorbol Acetate 119-122 keratin 14 Mus musculus 185-188 27889290-2 2017 Treatment with nuclear factor (erythroid-derived 2)-like 2 inducer sulforaphane ameliorated skin blistering in Krt14-null mice, correlating with induction of K17. sulforaphane 67-79 keratin 14 Mus musculus 111-116 27810232-4 2017 OBJECTIVE: To investigate which subsets of IL-17-producing cells are involved in psoriasis-like skin inflammation in a TPA (tumor promoter 12-O-tetradecanoylphorbol-13-acetate)-induced K14.Stat3C mouse model. Tetradecanoylphorbol Acetate 139-175 keratin 14 Mus musculus 185-188 27810232-5 2017 METHOD: Skin-infiltrating cells were isolated from inflamed lesions of TPA-treated K14.Stat3C transgenic mice, and analyzed for IL-17 producing cell subsets by flow cytometry. Tetradecanoylphorbol Acetate 71-74 keratin 14 Mus musculus 83-86 27810232-6 2017 RESULTS: We observed significantly increased numbers of IL-17-producing CD4+ T cells, CD8+ T cells and dermal gammadelta T cells in TPA-induced skin lesions of K14.Stat3C mice. Tetradecanoylphorbol Acetate 132-135 keratin 14 Mus musculus 160-163 27810232-11 2017 CONCLUSION: In TPA-induced lesional skin of K14.Stat3C mice, IL-17-producing CD4+ Th17 cells, CD8+ Tc17 cells, dermal gammadelta T cells and TCR- cells probably containing ILCs all participated in skin inflammation, which is similar to human clinical psoriatic features. Tetradecanoylphorbol Acetate 15-18 keratin 14 Mus musculus 44-47 27213341-8 2016 Moreover, Ppp2ca(flox/flox); Krt14-Cre mice had smaller size, melanin deposition and hyperproliferation at the base of the claws. Melanins 62-69 keratin 14 Mus musculus 29-34 26220468-0 2015 Anti-psoriatic effects of Honokiol through the inhibition of NF-kappaB and VEGFR-2 in animal model of K14-VEGF transgenic mouse. honokiol 26-34 keratin 14 Mus musculus 102-110 26919034-6 2016 Our study also suggests a potentially powerful model for complete ablation of Foxa1 in mammary epithelial cells using Krt14-driven Cre expression in an inducible manner, such as Krt14-rtTA;Tet-On-Cre. tetramethylenedisulfotetramine 189-192 keratin 14 Mus musculus 118-123 26978657-0 2016 Mechanosensory and ATP Release Deficits following Keratin14-Cre-Mediated TRPA1 Deletion Despite Absence of TRPA1 in Murine Keratinocytes. Adenosine Triphosphate 19-22 keratin 14 Mus musculus 50-59 26978657-8 2016 Overall, while these data suggest that the intended targeted deletion of Trpa1 from keratin 14-expressing cells of the epidermis induces functional deficits in mechanotransduction and ATP release, these deficits are in fact likely due to factors other than reduction of Trpa1 expression in adult mouse keratinocytes because they express very little, if any, Trpa1. Adenosine Triphosphate 184-187 keratin 14 Mus musculus 84-94 25168378-11 2016 pSmad2/3L-Thr immunostaining-positive cells showed co-localization with CDK4, p63, and CK14. Threonine 10-13 keratin 14 Mus musculus 87-91 24284744-4 2013 Weak expression of the keratinocyte early marker Cytokeratin 14 (CK-14) was observed up to 12 days when MESCs were cultured in a keratinocyte culture medium on tissue culture plastic and on a gelatin/collagen/polycaprolactone (GCP) biocomposite. polycaprolactone 209-225 keratin 14 Mus musculus 49-63 24342142-7 2014 A similar pattern of lncRNA profiling is observed in the epidermis of K14 driven, tamoxifen-regulated epidermal-specific VDR null vs. wild-type control mice. Tamoxifen 82-91 keratin 14 Mus musculus 70-73 25869667-1 2015 We recently reported that a trans-dimer, homotypic disulfide bond involving Cys367 in keratin 14 (K14) occurs in an atomic-resolution structure of the interacting K5/K14 2B domains and in keratinocyte cell lines. Disulfides 51-60 keratin 14 Mus musculus 86-96 25869667-1 2015 We recently reported that a trans-dimer, homotypic disulfide bond involving Cys367 in keratin 14 (K14) occurs in an atomic-resolution structure of the interacting K5/K14 2B domains and in keratinocyte cell lines. Disulfides 51-60 keratin 14 Mus musculus 98-101 25869667-1 2015 We recently reported that a trans-dimer, homotypic disulfide bond involving Cys367 in keratin 14 (K14) occurs in an atomic-resolution structure of the interacting K5/K14 2B domains and in keratinocyte cell lines. Disulfides 51-60 keratin 14 Mus musculus 166-169 25869667-2 2015 Here we show that a sizable fraction of the K14 and K5 protein pools participates in interkeratin disulfide bonding in primary cultures of mouse skin keratinocytes. Disulfides 98-107 keratin 14 Mus musculus 44-47 25869667-3 2015 By comparing the properties of wild-type K14 with a completely cysteine-free variant thereof, we found that K14-dependent disulfide bonding limited filament elongation during polymerization in vitro but was necessary for the genesis of a perinuclear-concentrated network of keratin filaments, normal keratin cycling, and the sessile behavior of the nucleus and whole cell in keratinocytes studied by live imaging. Cysteine 63-71 keratin 14 Mus musculus 108-111 25869667-3 2015 By comparing the properties of wild-type K14 with a completely cysteine-free variant thereof, we found that K14-dependent disulfide bonding limited filament elongation during polymerization in vitro but was necessary for the genesis of a perinuclear-concentrated network of keratin filaments, normal keratin cycling, and the sessile behavior of the nucleus and whole cell in keratinocytes studied by live imaging. Disulfides 122-131 keratin 14 Mus musculus 41-44 25869667-3 2015 By comparing the properties of wild-type K14 with a completely cysteine-free variant thereof, we found that K14-dependent disulfide bonding limited filament elongation during polymerization in vitro but was necessary for the genesis of a perinuclear-concentrated network of keratin filaments, normal keratin cycling, and the sessile behavior of the nucleus and whole cell in keratinocytes studied by live imaging. Disulfides 122-131 keratin 14 Mus musculus 108-111 25869667-4 2015 Many of these phenotypes were rescued when analyzing a K14 variant harboring a single Cys residue at position 367. Cysteine 86-89 keratin 14 Mus musculus 55-58 25869667-5 2015 These findings establish disulfide bonding as a novel and important mechanism regulating the assembly, intracellular organization, and dynamics of K14-containing intermediate filaments in skin keratinocytes. Disulfides 25-34 keratin 14 Mus musculus 147-150 25370987-9 2015 Keratin 14 protein, one of the 36 ketamine-induced downregulated genes, was also reduced in the ketamine-treated mouse bladder, as determined by immunohistochemical analysis. Ketamine 34-42 keratin 14 Mus musculus 0-10 25370987-9 2015 Keratin 14 protein, one of the 36 ketamine-induced downregulated genes, was also reduced in the ketamine-treated mouse bladder, as determined by immunohistochemical analysis. Ketamine 96-104 keratin 14 Mus musculus 0-10 24258150-6 2014 In the chemically induced SCC model, treatment of K14-Angptl2 Tg mice with the antioxidant N-acetyl cysteine (NAC) significantly reduced oxidative stress in skin tissue and the frequency of SCC development. Acetylcysteine 91-108 keratin 14 Mus musculus 50-53 24258150-6 2014 In the chemically induced SCC model, treatment of K14-Angptl2 Tg mice with the antioxidant N-acetyl cysteine (NAC) significantly reduced oxidative stress in skin tissue and the frequency of SCC development. Acetylcysteine 110-113 keratin 14 Mus musculus 50-53 24316079-5 2013 Similarly to ACBP(-/-) mice, K14-ACBP(-/-) mice exhibit an increased transepidermal water loss, and we show that the hepatic phenotype is caused specifically by the epidermal barrier defect, which leads to increased lipolysis in white adipose tissue. Water 84-89 keratin 14 Mus musculus 29-32 24284744-4 2013 Weak expression of the keratinocyte early marker Cytokeratin 14 (CK-14) was observed up to 12 days when MESCs were cultured in a keratinocyte culture medium on tissue culture plastic and on a gelatin/collagen/polycaprolactone (GCP) biocomposite. polycaprolactone 209-225 keratin 14 Mus musculus 65-70 23170909-11 2012 Two to four days after chlorine exposure, cell proliferation occurred in K5- and K14-expressing basal cells, and the number of K14 cells was dramatically increased. Chlorine 23-31 keratin 14 Mus musculus 81-84 23222816-5 2013 AZ expression also reduced progression to carcinoma in situ or invasive carcinoma and decreased expression of the squamous cell carcinoma biomarkers K14, cyclooxygenase-2 and metallothionein. alizarin 0-2 keratin 14 Mus musculus 149-152 23170909-11 2012 Two to four days after chlorine exposure, cell proliferation occurred in K5- and K14-expressing basal cells, and the number of K14 cells was dramatically increased. Chlorine 23-31 keratin 14 Mus musculus 127-130 22705788-3 2012 The interface of the K5-K14 coiled-coil heterodimer has asymmetric salt bridges, hydrogen bonds and hydrophobic contacts, and its surface exhibits a notable charge polarization. Hydrogen 81-89 keratin 14 Mus musculus 24-27 22705788-4 2012 A trans-dimer homotypic disulfide bond involving Cys367 in K14"s stutter region occurs in the crystal and in skin keratinocytes, where it is concentrated in a keratin filament cage enveloping the nucleus. Disulfides 24-33 keratin 14 Mus musculus 59-62 22357283-7 2012 DMBA treatment induces an activating mutation in the Harvey-ras (H-ras(61)) oncogene, and this mutation was identified in most papillomas and carcinomas although several papillomas and carcinomas in K14-LMP1 and K14-LMP1/LMP2A mice lacked the mutation. 9,10-Dimethyl-1,2-benzanthracene 0-4 keratin 14 Mus musculus 199-202 22357283-7 2012 DMBA treatment induces an activating mutation in the Harvey-ras (H-ras(61)) oncogene, and this mutation was identified in most papillomas and carcinomas although several papillomas and carcinomas in K14-LMP1 and K14-LMP1/LMP2A mice lacked the mutation. 9,10-Dimethyl-1,2-benzanthracene 0-4 keratin 14 Mus musculus 212-215 22514735-1 2012 Transgenic Keratin14-rtTA-PTR mice specifically express Keratin14 (K14) in the tongue epithelia, as well as co-express EGFP and the dominant negative DeltaTgfbr2 genes upon treatment with Doxycycline (Dox). Doxycycline 188-199 keratin 14 Mus musculus 11-20 22514735-1 2012 Transgenic Keratin14-rtTA-PTR mice specifically express Keratin14 (K14) in the tongue epithelia, as well as co-express EGFP and the dominant negative DeltaTgfbr2 genes upon treatment with Doxycycline (Dox). Doxycycline 188-191 keratin 14 Mus musculus 11-20 21593251-5 2011 Moreover, ectopic FasL protein induces apoptosis in MES of K14-Cre;Tgfbr2 (fl/fl) mice. 2-(N-morpholino)ethanesulfonic acid 52-55 keratin 14 Mus musculus 59-62 20926689-1 2010 Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007). sulforaphane 36-48 keratin 14 Mus musculus 85-95 21364190-2 2011 We studied 2 established models of acute cutaneous inflammation, namely, oxazolone-induced delayed-type hypersensitivity reactions and ultraviolet B irradiation, in keratin 14-vascular endothelial growth factor (VEGF)-C and keratin 14-VEGF-D transgenic mice. Oxazolone 73-82 keratin 14 Mus musculus 165-175 21494671-14 2011 Treatment of the K14-Cdx2 mice with 5"-Azacytidine elicited expression of BE-associated genes including Cdx1, Krt18, and Slc26a3/Dra, suggesting the phenotype could be advanced under certain conditions. Azacitidine 36-50 keratin 14 Mus musculus 17-20 22174914-6 2011 We successfully cloned KRT14 and p63 double-positive stratified epithelial progenitor cells from iPS-derived epithelial cells, which formed stratified epithelial sheets consisting of five- to six-polarized epithelial cells in vitro. IPS 97-100 keratin 14 Mus musculus 23-28 20926689-1 2010 Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007). sulforaphane 36-48 keratin 14 Mus musculus 97-100 20926689-1 2010 Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007). sulforaphane 50-52 keratin 14 Mus musculus 85-95 20926689-1 2010 Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007). sulforaphane 50-52 keratin 14 Mus musculus 97-100 18276784-3 2008 When such adult mice were exposed to Dox, they exhibited epithelial hyperplasia with increases in phospho-extracellular signal-regulated kinase 1/2-, nuclear beta-catenin-, and 5-bromo-2"-deoxyuridine-labeled cells and altered keratin (K) 14 (K14) expression pattern, a normal K12 expression pattern, and the normal absence of K10. Doxycycline 37-40 keratin 14 Mus musculus 243-246 19626033-6 2010 Unexpectedly, topical treatment of K14-RIP4 mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced dramatic, neutrophilic inflammation, an effect that was independent of tumor necrosis factor type 1 receptor (TNFR1/p55) function. Tetradecanoylphorbol Acetate 54-90 keratin 14 Mus musculus 35-38 19626033-6 2010 Unexpectedly, topical treatment of K14-RIP4 mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced dramatic, neutrophilic inflammation, an effect that was independent of tumor necrosis factor type 1 receptor (TNFR1/p55) function. Tetradecanoylphorbol Acetate 92-95 keratin 14 Mus musculus 35-38 19682281-6 2009 Lastly, UV sensitivity of K14-Scf congenic animals depended mainly on the amount of eumelanin present in the skin. eumelanin 84-93 keratin 14 Mus musculus 26-29 19435901-3 2009 Here, we have developed an inducible oral-specific animal tumor model system, which consists in the expression of a tamoxifen-inducible Cre recombinase (CreER(tam)) under the control of the cytokeratin 14 (K14) promoter (K14-CreER(tam)) and mice in which the endogenous K-ras locus is targeted (LSL-K-ras(G12D)), thereby causing the expression of endogenous levels of oncogenic K-ras(G12D) following removal of a stop element. Tamoxifen 116-125 keratin 14 Mus musculus 190-204 21328918-6 2010 Taking into consideration non-specific binding of mouse CK14 and rat CK8 with 5-aminocaproyl-Sepharose we have performed comparative analysis of amino acid sequences of human, mouse, and rat CK8 and CK14. 5-aminocaproyl-sepharose 78-102 keratin 14 Mus musculus 56-60 18579711-0 2008 TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis. Tetradecanoylphorbol Acetate 0-3 keratin 14 Mus musculus 58-66 18579711-5 2008 Inflammation was induced in the ear skin with five topical applications of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and a significantly increased inflammation was found in TPA-induced K14/VEGF transgenic animals compared with wild-type mice. Tetradecanoylphorbol Acetate 175-178 keratin 14 Mus musculus 187-190 18579711-11 2008 In conclusion, the TPA-induced phenotype in K14/VEGF animals displayed several features of psoriasis, including a T(h)17 cytokine profile and a chronic-like progression, and can be used as an in vivo screening model of psoriasis. Tetradecanoylphorbol Acetate 19-22 keratin 14 Mus musculus 44-47 17727842-7 2008 Retinoid topical treatments reduced p27 and CYP26A1 mRNA levels in TG(+) and TG(-) mouse skin in K14 and K10/FLAG-CRABPI transgenic mice. Retinoids 0-8 keratin 14 Mus musculus 97-100 16452183-6 2006 On comparison with all previous HK1.ras carcinomas, such TPA-induced carcinomas expressed atypical retention of keratin K1 and lack of K13, a unique marker profile exhibited by TPA-induced K14.cre/PTEN(flx/flx) papillomas that also lacked endogenous c-ras(Ha) activation. Tetradecanoylphorbol Acetate 57-60 keratin 14 Mus musculus 189-192 17583568-4 2007 62: 2516, 2002) that these mice, referred to as keratin 14 (K14).COX2 mice, were unexpectedly very resistant to 12-O-tetradecanoylphorbol 13-acetate (TPA) tumor promotion. Tetradecanoylphorbol Acetate 112-148 keratin 14 Mus musculus 48-58 17583568-4 2007 62: 2516, 2002) that these mice, referred to as keratin 14 (K14).COX2 mice, were unexpectedly very resistant to 12-O-tetradecanoylphorbol 13-acetate (TPA) tumor promotion. Tetradecanoylphorbol Acetate 112-148 keratin 14 Mus musculus 60-63 17583568-4 2007 62: 2516, 2002) that these mice, referred to as keratin 14 (K14).COX2 mice, were unexpectedly very resistant to 12-O-tetradecanoylphorbol 13-acetate (TPA) tumor promotion. Tetradecanoylphorbol Acetate 150-153 keratin 14 Mus musculus 48-58 17583568-4 2007 62: 2516, 2002) that these mice, referred to as keratin 14 (K14).COX2 mice, were unexpectedly very resistant to 12-O-tetradecanoylphorbol 13-acetate (TPA) tumor promotion. Tetradecanoylphorbol Acetate 150-153 keratin 14 Mus musculus 60-63 17583568-9 2007 This resistance phenotype appears to be restricted to phorbol ester promotion because K14.COX2 mice developed six times more tumors than wild-type mice when anthralin was used as the tumor promoter. Phorbol Esters 54-67 keratin 14 Mus musculus 86-89 17583568-9 2007 This resistance phenotype appears to be restricted to phorbol ester promotion because K14.COX2 mice developed six times more tumors than wild-type mice when anthralin was used as the tumor promoter. Anthralin 157-166 keratin 14 Mus musculus 86-89 17583568-10 2007 Additionally, K14.COX2 mice treated only with DMBA developed approximately 3.5 times more tumors than wild-type mice, suggesting that PGs have intrinsic tumor promoting activity. 9,10-Dimethyl-1,2-benzanthracene 46-50 keratin 14 Mus musculus 14-17 17583568-10 2007 Additionally, K14.COX2 mice treated only with DMBA developed approximately 3.5 times more tumors than wild-type mice, suggesting that PGs have intrinsic tumor promoting activity. Phosphatidylglycerols 134-137 keratin 14 Mus musculus 14-17 16518415-5 2006 When subjected to a two-stage chemical carcinogenesis protocol (dimethylbenz[alpha]anthracene (DMBA) initiation with 12-ortho-tetradecanoylphorbol-13-acetate promotion), K14.MCM7 mice showed significantly increased incidence and prevalence of tumor development relative to controls. dimethylbenz[alpha]anthracene 64-93 keratin 14 Mus musculus 170-173 17581617-1 2007 Epidermolysis bullosa simplex (EBS) is a skin disorder caused by mutations in keratin (K) 5 or K14 genes. simplex 22-29 keratin 14 Mus musculus 95-98 17724334-8 2007 Sulforaphane thus represents an attractive option for the prevention of skin blistering associated with K14 mutations in EBS. sulforaphane 0-12 keratin 14 Mus musculus 104-107 16452183-6 2006 On comparison with all previous HK1.ras carcinomas, such TPA-induced carcinomas expressed atypical retention of keratin K1 and lack of K13, a unique marker profile exhibited by TPA-induced K14.cre/PTEN(flx/flx) papillomas that also lacked endogenous c-ras(Ha) activation. Tetradecanoylphorbol Acetate 177-180 keratin 14 Mus musculus 189-192 16024603-5 2005 In response to the 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) mouse skin carcinogenesis protocol, K14-Pdcd4 mice showed significant reductions in papilloma formation, carcinoma incidence, and papilloma-to-carcinoma conversion frequency compared with wild-type mice. Tetradecanoylphorbol Acetate 57-93 keratin 14 Mus musculus 136-139 16024603-9 2005 In K14-Pdcd4 primary keratinocytes expressing activated Ha-Ras to mimic DMBA-initiated epidermis, ODC and CDK4 protein levels were decreased by 40% and 46%, respectively. 9,10-Dimethyl-1,2-benzanthracene 72-76 keratin 14 Mus musculus 3-6 15946242-11 2005 However, low level of phenylalanine clearance was observed in mice expressing PAH and GTP-CH from the K14 promoter, suggesting that the skin can be genetically engineered to function as a "metabolic sink". Phenylalanine 22-35 keratin 14 Mus musculus 102-105 15695401-5 2005 When K14-MEK mice were given alpha-difluoromethylornithine (DFMO), a suicide inactivator of ODC, in the drinking water from birth, there was a dramatic delay in the onset of tumor growth ( approximately 6 weeks), and only 25% of DFMO-treated mice developed tumors by 15 weeks of age. Eflornithine 29-58 keratin 14 Mus musculus 5-8 15917479-6 2005 Surface marker analysis revealed that the sorted SP cells expressed alpha6-integrin, beta1-integrin, Sca-1, keratin 14, and keratin 19, which are proliferating and progenitor cell markers, at levels higher than in non-SP cells, while they expressed E-cadherin, CD34, and CD71 at lower levels. sp 49-51 keratin 14 Mus musculus 108-118 15695401-5 2005 When K14-MEK mice were given alpha-difluoromethylornithine (DFMO), a suicide inactivator of ODC, in the drinking water from birth, there was a dramatic delay in the onset of tumor growth ( approximately 6 weeks), and only 25% of DFMO-treated mice developed tumors by 15 weeks of age. Eflornithine 60-64 keratin 14 Mus musculus 5-8 15695401-5 2005 When K14-MEK mice were given alpha-difluoromethylornithine (DFMO), a suicide inactivator of ODC, in the drinking water from birth, there was a dramatic delay in the onset of tumor growth ( approximately 6 weeks), and only 25% of DFMO-treated mice developed tumors by 15 weeks of age. Drinking Water 104-118 keratin 14 Mus musculus 5-8 15695401-5 2005 When K14-MEK mice were given alpha-difluoromethylornithine (DFMO), a suicide inactivator of ODC, in the drinking water from birth, there was a dramatic delay in the onset of tumor growth ( approximately 6 weeks), and only 25% of DFMO-treated mice developed tumors by 15 weeks of age. Eflornithine 229-233 keratin 14 Mus musculus 5-8 10876035-3 2000 Retinoic acid reduced the expression of CK14 and CKs recognized by polyclonal anti-keratin antibody, whereas it induced nestin. Tretinoin 0-13 keratin 14 Mus musculus 40-44 12566297-3 2003 K14-survivin mice were resistant to DMBA-induced keratinocyte apoptosis. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 36-40 keratin 14 Mus musculus 0-3 12566297-8 2003 Again, DMBA/PMA-induced tumor formation was less (71% versus 89%) and significantly delayed (P = 0.02) in K14-survivin p53+/- animals compared with p53+/- non-Tgs. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 7-11 keratin 14 Mus musculus 106-109 12566297-8 2003 Again, DMBA/PMA-induced tumor formation was less (71% versus 89%) and significantly delayed (P = 0.02) in K14-survivin p53+/- animals compared with p53+/- non-Tgs. Tetradecanoylphorbol Acetate 12-15 keratin 14 Mus musculus 106-109 15084463-4 2004 DeltaNbeta-cateninER was expressed in the epidermis of transgenic mice under the control of the keratin 14 promoter and beta-catenin activity was induced in adult epidermis by topical application of 4-hydroxytamoxifen (4OHT). deltanbeta-cateniner 0-20 keratin 14 Mus musculus 96-106 12759452-3 2003 Strikingly, the K14/IL-1 alpha mice were completely resistant to papilloma and carcinoma formation induced by a two-stage DMBA/TPA protocol, while littermate controls developed both tumor types. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 122-126 keratin 14 Mus musculus 16-19 12759452-3 2003 Strikingly, the K14/IL-1 alpha mice were completely resistant to papilloma and carcinoma formation induced by a two-stage DMBA/TPA protocol, while littermate controls developed both tumor types. Tetradecanoylphorbol Acetate 127-130 keratin 14 Mus musculus 16-19 12096830-4 2002 After DMBA treatment, K14-PTHrP mice showed a higher incidence of tumor formation and a shorter latency to tumor formation than wild-type littermates. 9,10-Dimethyl-1,2-benzanthracene 6-10 keratin 14 Mus musculus 22-25 11809846-5 2002 When type I and II assembly partners were switched to give rise to mismatched polymers (K5-K18; K8-K14), the interfilament interactions, which determine the structural and mechanical properties of keratin polymers, were significantly altered. Polymers 78-86 keratin 14 Mus musculus 99-102 35409002-6 2022 Here, we used an inducible oral-specific mouse model, where the expression of a tamoxifen-inducible Cre recombinase (CreERtam), which is under the control of the cytokeratin 14 promoter (K14-CreERtam), induces the expression of the K-ras oncogenic variant KrasG12D (LSLK-rasG12D). Tamoxifen 80-89 keratin 14 Mus musculus 162-176 11595821-5 2000 Furthermore, Tamoxifen administration to adult K14-Cre-ER(T2) mice efficiently induced recombination in the basal keratinocytes, whereas no background recombination was detected in the absence of ligand treatment. Tamoxifen 13-22 keratin 14 Mus musculus 47-50 34948000-10 2021 3-Methylcholanthrene (MCA)-induced cSCC in Flii overexpressing mice showed increased markers of cancer metastasis including talin and keratin-14 and a significant increase in SOX9 alongside a reduction in Flii associated protein (Flap-1). Methylcholanthrene 0-20 keratin 14 Mus musculus 134-144 34948000-10 2021 3-Methylcholanthrene (MCA)-induced cSCC in Flii overexpressing mice showed increased markers of cancer metastasis including talin and keratin-14 and a significant increase in SOX9 alongside a reduction in Flii associated protein (Flap-1). Methylcholanthrene 22-25 keratin 14 Mus musculus 134-144 34863129-8 2021 RESULTS: Levobunolol and ICI 118, 551 impaired corneal wound healing, decreased the expressions of CK3, CK14, and CK19 after limbal region scraping in vivo and reduced the migration and proliferation of TKE2 in vitro, whereas atenolol had no significant effect. Levobunolol 9-20 keratin 14 Mus musculus 104-108 10411913-7 1999 With K14-CreER(tam), postnatal transgenic mice show no Cre activity until tamoxifen is administered. Tamoxifen 74-83 keratin 14 Mus musculus 5-8 34407449-4 2022 In the present study, Krt14-cre/ERT-Kras transgenic mice were developed and the expression of K-RasG12D was induced by tamoxifen. Tamoxifen 119-128 keratin 14 Mus musculus 22-27 34515797-6 2021 Seven days of dermal exposure to triclosan decreased filaggrin 2 and keratin 10 expression, but increased filaggrin and keratin 14 protein along with the danger signal S100a8 and interleukin-4. Triclosan 33-42 keratin 14 Mus musculus 120-130 34815795-11 2021 Stem cell factor (SCF) introduction by crossing with KRT14-SCF mice increased epidermal melanocytes and melanin deposition in control and CRTC3-null mice, but the skin color remained still light on the CRTC3-null background. Melanins 104-111 keratin 14 Mus musculus 53-58 34085926-6 2021 Retinoic acid administration blocks development of ocular anomalies in Krt14-Cre; Relaf/f mice and naturally aged mice. Tretinoin 0-13 keratin 14 Mus musculus 71-76 35495722-6 2022 Additionally, CDCA supplements prevented metabolic disorders in K14-VEGF-A-transgenic mice. Chenodeoxycholic Acid 14-18 keratin 14 Mus musculus 64-67 35495722-7 2022 Consequently, we found that aberrant bile acid metabolism may contribute to metabolic disorder in K14-VEGF-A-transgenic mice, indicating the possibility to prevent and treat the metabolic disorder in psoriasis mice by targeting gut microbial metabolites. Bile Acids and Salts 37-46 keratin 14 Mus musculus 98-101 33195484-8 2020 Conversely, in CaCl2-induced AAA, K4/K9/K27/K36/K79 monomethylation and K9/K18/K56 acetylation were reduced in AAA tissues, whereas K27 di-/tri-methylation and K14 acetylation were upregulated. Calcium Chloride 15-20 keratin 14 Mus musculus 160-163 35514100-0 2022 Calcipotriol inhibits psoriasis-like angiogenic features in K14-VEGF transgenic mice. calcipotriene 0-12 keratin 14 Mus musculus 60-63 33385344-7 2021 Mice with conditional deletion of Fgfr2 in urothelium enriched for KRT14+ cells reproduced Fgfr2KO abnormalities after Cyclophosphamide. Cyclophosphamide 119-135 keratin 14 Mus musculus 67-72 33930539-13 2021 DS elicited K14+ epithelial cell displacement, as indicated by increased fluorescence signal at a distance of 50-100 mum radially inwards from the limbus [0.63 +- 0.053% (DS) vs 0.54 +- 0.060% (UT), p = 0.0317]. ds 0-2 keratin 14 Mus musculus 12-15 33754871-6 2021 Histological examinations highlighted the amelioration of the loss of keratine-14+ (KRT14+) basal ductal and/or MIST1+ acinar cells, as well as induction of fibrosis, following irradiation in EGF-treated mice. keratine-14+ 70-82 keratin 14 Mus musculus 84-89 31740391-10 2020 BAC treatment also modulated K14 expression and distribution within the limbus. Benzalkonium Compounds 0-3 keratin 14 Mus musculus 29-32 32032580-7 2020 In the present study, bleomycin (BLM)-induced skin fibrosis model was applied to keratinocyte-specific Nrf2 knockout (Nrf2(K)-KO) mice generated with Keratin 14-Cre/loxp system. Bleomycin 33-36 keratin 14 Mus musculus 150-160 32369015-0 2020 Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3sigma and YAP1. Disulfides 21-31 keratin 14 Mus musculus 0-10 32369015-2 2020 Recent studies evidenced a role for K14-dependent disulfide bonding in the organization and dynamics of keratin IFs in skin keratinocytes. Disulfides 50-59 keratin 14 Mus musculus 36-39 32369015-3 2020 Here we report that knock-in mice harboring a cysteine-to-alanine substitution at Krt14"s codon 373 (C373A) exhibit alterations in disulfide-bonded K14 species and a barrier defect secondary to enhanced proliferation, faster transit time and altered differentiation in epidermis. Cysteine 46-54 keratin 14 Mus musculus 82-87 32369015-3 2020 Here we report that knock-in mice harboring a cysteine-to-alanine substitution at Krt14"s codon 373 (C373A) exhibit alterations in disulfide-bonded K14 species and a barrier defect secondary to enhanced proliferation, faster transit time and altered differentiation in epidermis. Cysteine 46-54 keratin 14 Mus musculus 148-151 32369015-3 2020 Here we report that knock-in mice harboring a cysteine-to-alanine substitution at Krt14"s codon 373 (C373A) exhibit alterations in disulfide-bonded K14 species and a barrier defect secondary to enhanced proliferation, faster transit time and altered differentiation in epidermis. Alanine 58-65 keratin 14 Mus musculus 82-87 32369015-3 2020 Here we report that knock-in mice harboring a cysteine-to-alanine substitution at Krt14"s codon 373 (C373A) exhibit alterations in disulfide-bonded K14 species and a barrier defect secondary to enhanced proliferation, faster transit time and altered differentiation in epidermis. Alanine 58-65 keratin 14 Mus musculus 148-151 32369015-3 2020 Here we report that knock-in mice harboring a cysteine-to-alanine substitution at Krt14"s codon 373 (C373A) exhibit alterations in disulfide-bonded K14 species and a barrier defect secondary to enhanced proliferation, faster transit time and altered differentiation in epidermis. Disulfides 131-140 keratin 14 Mus musculus 82-87 32369015-3 2020 Here we report that knock-in mice harboring a cysteine-to-alanine substitution at Krt14"s codon 373 (C373A) exhibit alterations in disulfide-bonded K14 species and a barrier defect secondary to enhanced proliferation, faster transit time and altered differentiation in epidermis. Disulfides 131-140 keratin 14 Mus musculus 148-151 32369015-6 2020 Residue C373 in K14, which is conserved in a subset of keratins, is revealed as a novel regulator of keratin organization and YAP function in early differentiating keratinocytes, with an impact on cell mechanics, homeostasis and barrier function in epidermis. c373 8-12 keratin 14 Mus musculus 16-19 31242703-9 2019 Immunohistochemistry analyses showed overexpression of keratin14 and COX-2 in DT and DTP skin were profoundly suppressed by KWM-EO treatment. Thymidine 78-80 keratin 14 Mus musculus 55-64 31320708-4 2019 Using the KrasG12D/Trp53L/L lung cancer mouse model, we confirmed that K14-high cancer cells harbored increased metastatic potential. trp53l 19-25 keratin 14 Mus musculus 71-74 31597742-8 2019 These findings suggest that SIX1 is required for normal endometrial epithelial differentiation, CK14+/18+ cells act as a cancer progenitor population, and SIX1 delays DES-induced endometrial carcinogenesis by promoting basal differentiation of CK14+/18+ cells. Diethylstilbestrol 167-170 keratin 14 Mus musculus 96-100 31597742-8 2019 These findings suggest that SIX1 is required for normal endometrial epithelial differentiation, CK14+/18+ cells act as a cancer progenitor population, and SIX1 delays DES-induced endometrial carcinogenesis by promoting basal differentiation of CK14+/18+ cells. Diethylstilbestrol 167-170 keratin 14 Mus musculus 244-248 30905492-4 2019 METHODS: We evaluated the effect of topical S18-000003 on psoriasis-like skin inflammation and influence on the thymus in a 12-O-tetradecanoylphorbol-13-acetate-induced K14.Stat3C mouse psoriasis model. Tetradecanoylphorbol Acetate 124-160 keratin 14 Mus musculus 169-172 30891559-9 2018 Results: After 15 days of Dox induction, the expression of NTPDase2, Sox2 and K14 was ablated from lingual epithelia. Doxycycline 26-29 keratin 14 Mus musculus 78-81 30013199-6 2018 We selected a mouse model of nGD carrying a loxP-flanked neomycin disruption of Gba plus Cre recombinase regulated by the keratinocyte-specific K14 promoter. Neomycin 57-65 keratin 14 Mus musculus 144-147 29758119-2 2018 To do so, we developed tamoxifen-inducible double mutant (K-rasG12D -expressing and Ppp6c-deficient) mice in which K-rasG12D expression is driven by the cytokeratin 14 (K14) promoter. Tamoxifen 23-32 keratin 14 Mus musculus 153-167 29350066-7 2018 In BBN group, hyperplastic lesions showed significantly more CK14 and significantly less CK18 staining ( P < 0.05 in each case). Butylhydroxybutylnitrosamine 3-6 keratin 14 Mus musculus 61-65 29350066-12 2018 The results showed that hyperplastic lesions showed significantly more CK14 and significantly less CK18 staining and invasive carcinomas showed increased CK14 immunostaining in all epithelial layers in N-butyl- N-(4-hydroxybutyl)nitrosamine (BBN)-induced mouse model. Butylhydroxybutylnitrosamine 202-240 keratin 14 Mus musculus 154-158 29895210-4 2018 Both DES and GEN induced three distinct populations of abnormal endometrial epithelial cells: luminal (SIX1+/P63-/CK14-/CK18+), basal (SIX1+/P63+/CK14+/CK18-), and mixed/bipotential (SIX1+/P63-/CK14+/CK18+), which were all established by early adulthood. Diethylstilbestrol 5-8 keratin 14 Mus musculus 114-118 29895210-4 2018 Both DES and GEN induced three distinct populations of abnormal endometrial epithelial cells: luminal (SIX1+/P63-/CK14-/CK18+), basal (SIX1+/P63+/CK14+/CK18-), and mixed/bipotential (SIX1+/P63-/CK14+/CK18+), which were all established by early adulthood. Diethylstilbestrol 5-8 keratin 14 Mus musculus 146-150 29895210-4 2018 Both DES and GEN induced three distinct populations of abnormal endometrial epithelial cells: luminal (SIX1+/P63-/CK14-/CK18+), basal (SIX1+/P63+/CK14+/CK18-), and mixed/bipotential (SIX1+/P63-/CK14+/CK18+), which were all established by early adulthood. Diethylstilbestrol 5-8 keratin 14 Mus musculus 146-150