PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33893239-4	2021	We found that Siglec-4/7/15 all have distinct binding preferences for sialylated GalNAc-type O-glycans but exhibit selectivity for patterns of O-glycans as presented on distinct protein sequences.	N-acetylgalactosaminuronic acid	81-87	sialic acid binding Ig like lectin 7	Homo sapiens	14-27
33893239-4	2021	We found that Siglec-4/7/15 all have distinct binding preferences for sialylated GalNAc-type O-glycans but exhibit selectivity for patterns of O-glycans as presented on distinct protein sequences.	o-glycans	93-102	sialic acid binding Ig like lectin 7	Homo sapiens	14-27
33893239-4	2021	We found that Siglec-4/7/15 all have distinct binding preferences for sialylated GalNAc-type O-glycans but exhibit selectivity for patterns of O-glycans as presented on distinct protein sequences.	o-glycans	143-152	sialic acid binding Ig like lectin 7	Homo sapiens	14-27
33495350-5	2021	Further work identified a specific N-terminal glycopeptide region of CD43 containing clusters of disialylated O-glycan tetrasaccharides that form specific Siglec-7 binding motifs.	tetrasaccharides	119-135	sialic acid binding Ig like lectin 7	Homo sapiens	155-163
33640457-4	2021	We affinity-purified the ligands using Fc-ligated recombinant Siglec-7 and diSia-dextran polymer, a strong inhibitor for Siglec-7.	disia-dextran polymer	75-96	sialic acid binding Ig like lectin 7	Homo sapiens	121-129
33640457-7	2021	Taken together, our data suggest that leukosialin on K562 is a counter-receptor for Siglec-7 on NK cells and that a cluster of the Sia-containing glycan epitope on leukosialin is key as trans-ligand for unmasking the cis-ligand.	Polysaccharides	146-152	sialic acid binding Ig like lectin 7	Homo sapiens	84-92
33013909-5	2020	Among these receptors, Siglec 7 (p75/AIRM-1), LAIR-1 and IRp60, recognize ligands including sialic acids, extracellular matrix/collagen or aminophospholipids, respectively.	Sialic Acids	92-104	sialic acid binding Ig like lectin 7	Homo sapiens	23-31
33248687-0	2021	The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid.	Arginine	14-22	sialic acid binding Ig like lectin 7	Homo sapiens	63-71
33248687-0	2021	The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid.	N-Acetylneuraminic Acid	83-94	sialic acid binding Ig like lectin 7	Homo sapiens	63-71
33248687-2	2021	Recently, a new Sia binding site in Siglec-7, termed site 2, where arginine (R) 67 was critical, was identified by computational modeling and biochemical analyses, relative to the primary Sia binding site, termed site 1, containing critical R124.	Arginine	67-75	sialic acid binding Ig like lectin 7	Homo sapiens	36-44
33495350-0	2021	Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7.	Polysaccharides	60-66	sialic acid binding Ig like lectin 7	Homo sapiens	102-110
33495350-3	2021	Here, we present a CRISPRi genomic screening strategy that allowed unbiased identification of the key genes required for cell-surface presentation of glycan ligands on leukemia cells that bind the glyco-immune checkpoint receptors Siglec-7 and Siglec-9.	Polysaccharides	150-156	sialic acid binding Ig like lectin 7	Homo sapiens	231-239
33495350-5	2021	Further work identified a specific N-terminal glycopeptide region of CD43 containing clusters of disialylated O-glycan tetrasaccharides that form specific Siglec-7 binding motifs.	o-glycan	110-118	sialic acid binding Ig like lectin 7	Homo sapiens	155-163
33013909-5	2020	Among these receptors, Siglec 7 (p75/AIRM-1), LAIR-1 and IRp60, recognize ligands including sialic acids, extracellular matrix/collagen or aminophospholipids, respectively.	Sialic Acids	92-104	sialic acid binding Ig like lectin 7	Homo sapiens	33-36
33013909-5	2020	Among these receptors, Siglec 7 (p75/AIRM-1), LAIR-1 and IRp60, recognize ligands including sialic acids, extracellular matrix/collagen or aminophospholipids, respectively.	Sialic Acids	92-104	sialic acid binding Ig like lectin 7	Homo sapiens	37-43
33013909-5	2020	Among these receptors, Siglec 7 (p75/AIRM-1), LAIR-1 and IRp60, recognize ligands including sialic acids, extracellular matrix/collagen or aminophospholipids, respectively.	aminophospholipids	139-157	sialic acid binding Ig like lectin 7	Homo sapiens	23-31
33013909-5	2020	Among these receptors, Siglec 7 (p75/AIRM-1), LAIR-1 and IRp60, recognize ligands including sialic acids, extracellular matrix/collagen or aminophospholipids, respectively.	aminophospholipids	139-157	sialic acid binding Ig like lectin 7	Homo sapiens	33-36
33013909-5	2020	Among these receptors, Siglec 7 (p75/AIRM-1), LAIR-1 and IRp60, recognize ligands including sialic acids, extracellular matrix/collagen or aminophospholipids, respectively.	aminophospholipids	139-157	sialic acid binding Ig like lectin 7	Homo sapiens	37-43
32457377-0	2020	Discovery of a new sialic acid binding region that regulates Siglec-7.	N-Acetylneuraminic Acid	19-30	sialic acid binding Ig like lectin 7	Homo sapiens	61-69
32513821-8	2020	Siglec-7 mediated the binding and biological actions of GdA in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	65-76	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
32391973-5	2020	In this regard, siglec-7 and -9 are found on immune cells, such as natural killer cells, T-cells, and dendritic cells and they can promote immune suppression when binding to sialic acids expressed on target cells.	Sialic Acids	174-186	sialic acid binding Ig like lectin 7	Homo sapiens	16-31
32457377-2	2020	Siglec-7 is considered to function as an immunoreceptor in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	61-72	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
32457377-4	2020	Here, to gain new insights into the ligand-binding properties of Siglec-7, we carried out in silico analysis and site-directed mutagenesis, and found a new sialic acid-binding region (site 2 containing R67) in addition to the well-known primary ligand-binding region (site 1 containing R124).	N-Acetylneuraminic Acid	156-167	sialic acid binding Ig like lectin 7	Homo sapiens	65-73
32457377-5	2020	This was supported by equilibrium dialysis, STD-NMR experiments, and inhibition analysis of GD3-binding toward Siglec-7 using synthetic sialoglycoconjugates and a comprehensive set of ganglioside-based glycoconjugates.	Gangliosides	184-195	sialic acid binding Ig like lectin 7	Homo sapiens	111-119
32027025-6	2020	Additionally, by using histone deacetylases (HDAC) inhibitor, butyric acid, we showed that Siglec-7 expression was also subjected to the histone modification.	Butyric Acid	62-74	sialic acid binding Ig like lectin 7	Homo sapiens	91-99
32027025-7	2020	And a combined treatment with both 5-azacytidine and butyric acid showed an additive effect on Siglec-7 transcript expression in peripheral NK cells.	Azacitidine	35-48	sialic acid binding Ig like lectin 7	Homo sapiens	95-103
32027025-7	2020	And a combined treatment with both 5-azacytidine and butyric acid showed an additive effect on Siglec-7 transcript expression in peripheral NK cells.	Butyric Acid	53-65	sialic acid binding Ig like lectin 7	Homo sapiens	95-103
31138648-1	2019	To analyze the binding specificity of a sialic acid-recognizing lectin, sialic acid-binding Ig-like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3-expressing cells by introducing GD3 synthase (GD3S or ST8SIA1) cDNA into a colon cancer cell line, DLD-1, that expresses no ligands for the recombinant protein SIGLEC7-Fc.	N-Acetylneuraminic Acid	40-51	sialic acid binding Ig like lectin 7	Homo sapiens	337-344
32322597-2	2020	Previous studies have shown that Siglec7 and Siglec9 are expressed on NK cells, which negatively regulate the function of NK cells and modulate the immune response through the interaction of sialic acid-containing ligands.	N-Acetylneuraminic Acid	191-202	sialic acid binding Ig like lectin 7	Homo sapiens	33-40
31339142-3	2019	Glycan microarray binding studies indicate that Siglec-7 does not recognize DSGb5, and preferentially binds Neu5Acalpha(2,8)Neu5Ac containing glycans.	Polysaccharides	0-6	sialic acid binding Ig like lectin 7	Homo sapiens	48-56
31339142-3	2019	Glycan microarray binding studies indicate that Siglec-7 does not recognize DSGb5, and preferentially binds Neu5Acalpha(2,8)Neu5Ac containing glycans.	N-Acetylneuraminic Acid	108-114	sialic acid binding Ig like lectin 7	Homo sapiens	48-56
31339142-3	2019	Glycan microarray binding studies indicate that Siglec-7 does not recognize DSGb5, and preferentially binds Neu5Acalpha(2,8)Neu5Ac containing glycans.	Polysaccharides	142-149	sialic acid binding Ig like lectin 7	Homo sapiens	48-56
31140679-2	2019	Siglec-7 shows preference for disialylated glycans, including alpha(2,8)-alpha(2,3)-disialic acids or internally branched alpha(2,6)-NeuAc, such as disialosylglobopentaose (DSGb5).	Polysaccharides	43-50	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
31140679-2	2019	Siglec-7 shows preference for disialylated glycans, including alpha(2,8)-alpha(2,3)-disialic acids or internally branched alpha(2,6)-NeuAc, such as disialosylglobopentaose (DSGb5).	alpha(2,8)-alpha(2,3)-disialic acids	62-98	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
31140679-2	2019	Siglec-7 shows preference for disialylated glycans, including alpha(2,8)-alpha(2,3)-disialic acids or internally branched alpha(2,6)-NeuAc, such as disialosylglobopentaose (DSGb5).	alpha(2,6)-neuac	122-138	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
31140679-2	2019	Siglec-7 shows preference for disialylated glycans, including alpha(2,8)-alpha(2,3)-disialic acids or internally branched alpha(2,6)-NeuAc, such as disialosylglobopentaose (DSGb5).	disialosylglobopentaose	148-171	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
31140679-2	2019	Siglec-7 shows preference for disialylated glycans, including alpha(2,8)-alpha(2,3)-disialic acids or internally branched alpha(2,6)-NeuAc, such as disialosylglobopentaose (DSGb5).	dsgb5	173-178	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
31140679-7	2019	Surprisingly, DSGb5 shows a low affinity for Siglec-7 in a glycan microarray binding affinity assay.	Polysaccharides	59-65	sialic acid binding Ig like lectin 7	Homo sapiens	45-53
31140679-8	2019	Among the synthesized globo-series glycans, alpha6alpha3DSGb4 shows the highest binding affinity for Siglec-7.	Polysaccharides	35-42	sialic acid binding Ig like lectin 7	Homo sapiens	101-109
31138648-0	2019	The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface.	Ceramides	4-12	sialic acid binding Ig like lectin 7	Homo sapiens	115-122
31138648-0	2019	The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface.	sialogangliosides	23-41	sialic acid binding Ig like lectin 7	Homo sapiens	115-122
31138648-0	2019	The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface.	N-Acetylneuraminic Acid	88-99	sialic acid binding Ig like lectin 7	Homo sapiens	115-122
31138648-1	2019	To analyze the binding specificity of a sialic acid-recognizing lectin, sialic acid-binding Ig-like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3-expressing cells by introducing GD3 synthase (GD3S or ST8SIA1) cDNA into a colon cancer cell line, DLD-1, that expresses no ligands for the recombinant protein SIGLEC7-Fc.	N-Acetylneuraminic Acid	40-51	sialic acid binding Ig like lectin 7	Homo sapiens	72-108
31138648-1	2019	To analyze the binding specificity of a sialic acid-recognizing lectin, sialic acid-binding Ig-like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3-expressing cells by introducing GD3 synthase (GD3S or ST8SIA1) cDNA into a colon cancer cell line, DLD-1, that expresses no ligands for the recombinant protein SIGLEC7-Fc.	N-Acetylneuraminic Acid	40-51	sialic acid binding Ig like lectin 7	Homo sapiens	110-117
31138648-1	2019	To analyze the binding specificity of a sialic acid-recognizing lectin, sialic acid-binding Ig-like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3-expressing cells by introducing GD3 synthase (GD3S or ST8SIA1) cDNA into a colon cancer cell line, DLD-1, that expresses no ligands for the recombinant protein SIGLEC7-Fc.	disialyl gangliosides	123-144	sialic acid binding Ig like lectin 7	Homo sapiens	72-108
31138648-1	2019	To analyze the binding specificity of a sialic acid-recognizing lectin, sialic acid-binding Ig-like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3-expressing cells by introducing GD3 synthase (GD3S or ST8SIA1) cDNA into a colon cancer cell line, DLD-1, that expresses no ligands for the recombinant protein SIGLEC7-Fc.	disialyl gangliosides	123-144	sialic acid binding Ig like lectin 7	Homo sapiens	110-117
31138648-3	2019	Because milk-derived GD3 could be recognized by this fusion protein when incorporated onto the surface of DLD-1 cells, we compared the ceramides in DLD-1-generated and milk-derived GD3s to identify the SIGLEC7-specific GD3 structures on the cell membrane, revealing that SIGLEC7 recognizes only GD3-containing regular ceramides but not phytoceramides.	Ceramides	318-327	sialic acid binding Ig like lectin 7	Homo sapiens	202-209
31138648-3	2019	Because milk-derived GD3 could be recognized by this fusion protein when incorporated onto the surface of DLD-1 cells, we compared the ceramides in DLD-1-generated and milk-derived GD3s to identify the SIGLEC7-specific GD3 structures on the cell membrane, revealing that SIGLEC7 recognizes only GD3-containing regular ceramides but not phytoceramides.	phytoceramides	336-350	sialic acid binding Ig like lectin 7	Homo sapiens	202-209
31138648-4	2019	This was confirmed by knockdown/knockout of the sphingolipid delta(4)-desaturase/C4-monooxygenase (DES2) gene, involved in phytoceramide synthesis, disclosing that DES2 inhibition confers SIGLEC7 binding.	Sphingolipids	48-60	sialic acid binding Ig like lectin 7	Homo sapiens	188-195
31138648-4	2019	This was confirmed by knockdown/knockout of the sphingolipid delta(4)-desaturase/C4-monooxygenase (DES2) gene, involved in phytoceramide synthesis, disclosing that DES2 inhibition confers SIGLEC7 binding.	phytoceramide	123-136	sialic acid binding Ig like lectin 7	Homo sapiens	188-195
31138648-8	2019	These results indicate that the ceramide structures in glycosphingolipids affect SIGLEC7 binding and distribution on the cell surface and influence cell sensitivity to killing by SIGLEC7-expressing effector cells.	Ceramides	32-40	sialic acid binding Ig like lectin 7	Homo sapiens	81-88
31138648-8	2019	These results indicate that the ceramide structures in glycosphingolipids affect SIGLEC7 binding and distribution on the cell surface and influence cell sensitivity to killing by SIGLEC7-expressing effector cells.	Ceramides	32-40	sialic acid binding Ig like lectin 7	Homo sapiens	179-186
31138648-8	2019	These results indicate that the ceramide structures in glycosphingolipids affect SIGLEC7 binding and distribution on the cell surface and influence cell sensitivity to killing by SIGLEC7-expressing effector cells.	Glycosphingolipids	55-73	sialic acid binding Ig like lectin 7	Homo sapiens	81-88
31138648-8	2019	These results indicate that the ceramide structures in glycosphingolipids affect SIGLEC7 binding and distribution on the cell surface and influence cell sensitivity to killing by SIGLEC7-expressing effector cells.	Glycosphingolipids	55-73	sialic acid binding Ig like lectin 7	Homo sapiens	179-186
28374980-0	2017	Chemical Synthesis and Evaluation of a Disialic Acid-Containing Dextran Polymer as an Inhibitor for the Interaction between Siglec 7 and Its Ligand.	disialic acid	39-52	sialic acid binding Ig like lectin 7	Homo sapiens	124-132
30953118-10	2019	Interestingly, freshly isolated glioma cells predominantly expressed sialic acid ligands for Siglec-7 and -9, which was confirmed in situ.	N-Acetylneuraminic Acid	69-80	sialic acid binding Ig like lectin 7	Homo sapiens	93-108
29388006-5	2018	Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2.	Polysaccharides	66-73	sialic acid binding Ig like lectin 7	Homo sapiens	211-219
31143186-5	2019	Two inhibitory sialic acid-binding immunoglobulin-like lectin (Siglec) receptors are expressed by NK cells: Siglec-7 and Siglec-9.	N-Acetylneuraminic Acid	15-26	sialic acid binding Ig like lectin 7	Homo sapiens	108-116
31143186-6	2019	The abundance of sialic acids on tumor cell surface is hypothesized to regulate NK cell-mediated cytotoxicity by interacting with Siglec-7 and Siglec-9, causing a dampening of NK cell activation pathways.	Sialic Acids	17-29	sialic acid binding Ig like lectin 7	Homo sapiens	130-138
30317754-1	2018	Objective: To explore the relationship between sialic-acid-binding immunoglobulin-like lectin 7 (Siglec-7) expressed on NK cells and hepatitis B virus-related cirrhosis.	N-Acetylneuraminic Acid	47-58	sialic acid binding Ig like lectin 7	Homo sapiens	97-105
28374980-0	2017	Chemical Synthesis and Evaluation of a Disialic Acid-Containing Dextran Polymer as an Inhibitor for the Interaction between Siglec 7 and Its Ligand.	Dextrans	64-71	sialic acid binding Ig like lectin 7	Homo sapiens	124-132
28374980-5	2017	DiSia-Dex showed high binding avidity toward Siglec7, with a KD value of 5.87x10-10  m, and a high inhibitory activity for the interaction between Siglec7 and a ligand (GD3), with a IC50 value of 1.0 nm.	disia-dex	0-9	sialic acid binding Ig like lectin 7	Homo sapiens	45-52
28374980-5	2017	DiSia-Dex showed high binding avidity toward Siglec7, with a KD value of 5.87x10-10  m, and a high inhibitory activity for the interaction between Siglec7 and a ligand (GD3), with a IC50 value of 1.0 nm.	disia-dex	0-9	sialic acid binding Ig like lectin 7	Homo sapiens	147-154
28374980-6	2017	Notably, diSia-Dex was able to release Siglec7 from the pre-existing Siglec7-GD3 complex, possibly due to its unique properties of a slow dissociation rate and a high association rate.	disia-dex	9-18	sialic acid binding Ig like lectin 7	Homo sapiens	39-46
28374980-6	2017	Notably, diSia-Dex was able to release Siglec7 from the pre-existing Siglec7-GD3 complex, possibly due to its unique properties of a slow dissociation rate and a high association rate.	disia-dex	9-18	sialic acid binding Ig like lectin 7	Homo sapiens	69-76
28374980-7	2017	Together, these data show that diSia-Dex can be widely applicable as a modulator of Siglec7 functions.	disia-dex	31-40	sialic acid binding Ig like lectin 7	Homo sapiens	84-91
26258433-6	2015	Furthermore, Ac5NeuNPoc-based sialic acid glycoengineering enabled the on-cell synthesis of high-affinity Siglec-7 ligands and the identification of a novel Siglec-2 ligand.	N-Acetylneuraminic Acid	30-41	sialic acid binding Ig like lectin 7	Homo sapiens	106-114
28386256-7	2017	In particular, the sialic acid residues present on gp120 can bind Siglec-7 on natural killer and monocytes/macrophages and Siglec-1 on monocytes/macrophages and dendritic cells.	N-Acetylneuraminic Acid	19-30	sialic acid binding Ig like lectin 7	Homo sapiens	66-74
28103033-6	2017	They display up to a 5000-fold enhanced affinity over the unmodified sialic acid scaffold alphaMe Neu5Ac, the smallest known natural Siglec-7 ligand.	N-Acetylneuraminic Acid	69-80	sialic acid binding Ig like lectin 7	Homo sapiens	133-141
28103033-6	2017	They display up to a 5000-fold enhanced affinity over the unmodified sialic acid scaffold alphaMe Neu5Ac, the smallest known natural Siglec-7 ligand.	alphame neu5ac	90-104	sialic acid binding Ig like lectin 7	Homo sapiens	133-141
28553076-10	2017	Compared with Group P2.5, the CR rate was significantly improved at all intervals in Group P+D, except at 4-72 h, and was also elevated at 24-72 h in Group P7.5 (P<0.05).	Chromium	30-32	sialic acid binding Ig like lectin 7	Homo sapiens	156-160
27874015-7	2017	Treatment with Ac53FaxNeu5Ac abrogated putative cis and trans interactions between sialic acids and Siglec-7/-9.	Ac53FaxNeu5Ac	15-28	sialic acid binding Ig like lectin 7	Homo sapiens	100-111
27874015-7	2017	Treatment with Ac53FaxNeu5Ac abrogated putative cis and trans interactions between sialic acids and Siglec-7/-9.	Sialic Acids	83-95	sialic acid binding Ig like lectin 7	Homo sapiens	100-111
27874015-8	2017	Together, these data indicate that sialic acids limit the activation of moDCs via the TLR pathway, potentially by interacting with Siglec-7 or Siglec-9.	Sialic Acids	35-47	sialic acid binding Ig like lectin 7	Homo sapiens	131-139
28103033-5	2017	The compounds are Sialic acid derivatives and bind with low micromolar Kd values to Siglec-7.	N-Acetylneuraminic Acid	18-29	sialic acid binding Ig like lectin 7	Homo sapiens	84-92
27973630-0	2017	Synthesis of end-functionalized glycopolymers containing alpha(2,8) disialic acids via pi-allyl nickel catalyzed coordinating polymerization and their interaction with Siglec-7.	glycopolymers	32-45	sialic acid binding Ig like lectin 7	Homo sapiens	168-176
27973630-0	2017	Synthesis of end-functionalized glycopolymers containing alpha(2,8) disialic acids via pi-allyl nickel catalyzed coordinating polymerization and their interaction with Siglec-7.	alpha(2,8) disialic acids	57-82	sialic acid binding Ig like lectin 7	Homo sapiens	168-176
27973630-0	2017	Synthesis of end-functionalized glycopolymers containing alpha(2,8) disialic acids via pi-allyl nickel catalyzed coordinating polymerization and their interaction with Siglec-7.	Nickel	96-102	sialic acid binding Ig like lectin 7	Homo sapiens	168-176
27973630-3	2017	The glycopolymers can dissociate Siglec-7-GD3 interactions at low concentrations.	glycopolymers	4-17	sialic acid binding Ig like lectin 7	Homo sapiens	33-45
26674359-1	2016	OBJECTIVE: Sialic-acid-binding immunoglobulin-like lectin-7 (Siglec-7) is a natural killer (NK) cell inhibitory receptor associated with NK phenotypic and functional abnormalities in HIV-1 infection.	N-Acetylneuraminic Acid	11-22	sialic acid binding Ig like lectin 7	Homo sapiens	61-69
26674359-7	2016	The frequency of Siglec-7pos NK cells was significantly higher at baseline in sustained virological responders to pegylated interferon-alpha/ribavirin treatment than in non-responders.	Ribavirin	141-150	sialic acid binding Ig like lectin 7	Homo sapiens	17-25
25277834-5	2014	We succeeded in the synthesis of siglec-7 by installing three extra cysteine residues with side-chain modifications and found that these modifications did not affect the binding activity.	Cysteine	68-76	sialic acid binding Ig like lectin 7	Homo sapiens	33-41
26234906-0	2015	Synthesis and biological evaluation of 9-N-oxamyl sialosides as Siglec-7 ligands.	9-n-oxamyl sialosides	39-60	sialic acid binding Ig like lectin 7	Homo sapiens	64-72
26234906-3	2015	Here we present design, synthesis, affinity evaluation and molecular modeling of novel 9-N-oxamoyl modified sialosides as Siglec-7 ligands.	9-n-oxamoyl modified sialosides	87-118	sialic acid binding Ig like lectin 7	Homo sapiens	122-130
25277834-0	2014	Chemical synthesis of a synthetic analogue of the sialic acid-binding lectin siglec-7.	N-Acetylneuraminic Acid	50-61	sialic acid binding Ig like lectin 7	Homo sapiens	77-85
25000981-8	2014	These data suggest that the endocytic function of Siglec-7 can be exploited to deliver glycolipid Ags to their target cell and increase the efficiency of display to T cells.	Glycolipids	87-97	sialic acid binding Ig like lectin 7	Homo sapiens	50-58
25277834-1	2014	As a basis for the development of an artificial carbohydrate-binding lectin, we chemically synthesized a domain of siglec-7, a well-characterized sialic-acid-binding lectin.	Carbohydrates	48-60	sialic acid binding Ig like lectin 7	Homo sapiens	115-123
25277834-1	2014	As a basis for the development of an artificial carbohydrate-binding lectin, we chemically synthesized a domain of siglec-7, a well-characterized sialic-acid-binding lectin.	N-Acetylneuraminic Acid	146-157	sialic acid binding Ig like lectin 7	Homo sapiens	115-123
25277834-4	2014	After folding the full-length polypeptide, the sialic-acid-binding activity of the synthetic siglec-7 was clearly demonstrated by STD NMR and ELISA experiments.	N-Acetylneuraminic Acid	47-58	sialic acid binding Ig like lectin 7	Homo sapiens	93-101
25230315-6	2014	Cross-linking Siglec-7 with its ligand, ganglioside, resulted in platelet apoptosis without any significant effects on activation, aggregation, cell morphology by electron microscopy analysis or secretion.	Gangliosides	40-51	sialic acid binding Ig like lectin 7	Homo sapiens	14-22
25230315-8	2014	Inhibition of NAPDH oxidase, PI3K, or PKC rescued platelets from apoptosis induced by Siglec-7 recruitment, suggesting that the platelet receptors P2Y1 and GPIIbIIIa are essential for ganglioside-induced platelet apoptosis.	Gangliosides	184-195	sialic acid binding Ig like lectin 7	Homo sapiens	86-94
22585296-6	2012	Sialic acid-dependent binding of siglec-7 tetramers was confirmed by glycan array analysis and loss of siglec tetramer binding after neuraminidase treatment of lymphocytes.	N-Acetylneuraminic Acid	0-11	sialic acid binding Ig like lectin 7	Homo sapiens	33-41
24569453-2	2014	The sialic acid-binding Ig-like lectins Siglec-7 and -9 are MHC class I-independent inhibitory receptors on human NK cells that recognize sialic acid-containing carbohydrates.	N-Acetylneuraminic Acid	4-15	sialic acid binding Ig like lectin 7	Homo sapiens	40-55
24569453-2	2014	The sialic acid-binding Ig-like lectins Siglec-7 and -9 are MHC class I-independent inhibitory receptors on human NK cells that recognize sialic acid-containing carbohydrates.	N-Acetylneuraminic Acid	138-149	sialic acid binding Ig like lectin 7	Homo sapiens	40-55
24569453-2	2014	The sialic acid-binding Ig-like lectins Siglec-7 and -9 are MHC class I-independent inhibitory receptors on human NK cells that recognize sialic acid-containing carbohydrates.	Carbohydrates	161-174	sialic acid binding Ig like lectin 7	Homo sapiens	40-55
23597400-0	2013	On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7.	sialoside	37-46	sialic acid binding Ig like lectin 7	Homo sapiens	89-97
23597400-6	2013	In silico docking to the crystal structure of Siglec-7 provides a rationale for the affinity gains observed for this novel sialic acid analogue.	N-Acetylneuraminic Acid	123-134	sialic acid binding Ig like lectin 7	Homo sapiens	46-54
23173866-5	2013	Using a well-defined GBS/MFS-associated C. jejuni strain collection, which included three sialic acid knockout strains, we found that Siglec-7 exclusively binds to C. jejuni strains that express terminal disialylated ganglioside mimics.	N-Acetylneuraminic Acid	90-101	sialic acid binding Ig like lectin 7	Homo sapiens	134-142
23173866-5	2013	Using a well-defined GBS/MFS-associated C. jejuni strain collection, which included three sialic acid knockout strains, we found that Siglec-7 exclusively binds to C. jejuni strains that express terminal disialylated ganglioside mimics.	Gangliosides	217-228	sialic acid binding Ig like lectin 7	Homo sapiens	134-142
23173866-8	2013	Lipo-oligosaccharide-specific binding of C. jejuni to Siglec-7 may be an initiating event in immune recognition and presentation, and lead to anti-GQ1b antibody production and the development of ocular weakness in GBS or MFS.	lipid-linked oligosaccharides	0-20	sialic acid binding Ig like lectin 7	Homo sapiens	54-62
24370703-5	2014	The two different rm8Delta strains induced antigen-specific immunity; however, m8Delta-pSFJ-JRCSFenv elicited a stronger anti-Env antibody response whereas m8Delta-p7.5-JRCSFenv induced a stronger Env-specific cytotoxic T lymphocyte response.	rm8delta	18-26	sialic acid binding Ig like lectin 7	Homo sapiens	164-168
24292068-3	2014	Here, we show that increasing sialylated glycans on cancer cells inhibits human natural killer (NK) cell activation through the recruitment of sialic acid-binding immunoglobulin-like lectin 7 (Siglec-7).	Polysaccharides	41-48	sialic acid binding Ig like lectin 7	Homo sapiens	143-191
24292068-3	2014	Here, we show that increasing sialylated glycans on cancer cells inhibits human natural killer (NK) cell activation through the recruitment of sialic acid-binding immunoglobulin-like lectin 7 (Siglec-7).	Polysaccharides	41-48	sialic acid binding Ig like lectin 7	Homo sapiens	193-201
24330394-1	2013	BACKGROUND: Sialic acid-binding Ig-like lectin-7 (Siglec-7) expression is strongly reduced on natural killer (NK) cells from HIV-1 infected viremic patients.	N-Acetylneuraminic Acid	12-23	sialic acid binding Ig like lectin 7	Homo sapiens	50-58
24330394-3	2013	RESULTS: The ability of Siglec-7 to bind gp120 Env in a sialic acid-dependent manner facilitates the infection of both T cells and monocyte-derived macrophages (MDMs).	N-Acetylneuraminic Acid	56-67	sialic acid binding Ig like lectin 7	Homo sapiens	24-32
23173866-3	2013	Antigen recognition is a crucial first step in the induction of a cross-reactive antibody response, and it has been shown that GQ1b-like epitopes expressed on the surface of C. jejuni are recognized by sialic acid-binding immunoglobulin-like lectin-7 (Siglec-7).	N-Acetylneuraminic Acid	202-213	sialic acid binding Ig like lectin 7	Homo sapiens	252-260
22585296-6	2012	Sialic acid-dependent binding of siglec-7 tetramers was confirmed by glycan array analysis and loss of siglec tetramer binding after neuraminidase treatment of lymphocytes.	Polysaccharides	69-75	sialic acid binding Ig like lectin 7	Homo sapiens	33-41
20032046-1	2010	Siglec-7, a sialic acid binding immunoglobulin-like lectin, predominantly transduces inhibitory signals through cytosolic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).	N-Acetylneuraminic Acid	12-23	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
22377735-5	2012	Siglec-3, Siglec-7 and Siglec-2 exhibited moderately stronger binding to pCA125 antigen than the others.	pca125	73-79	sialic acid binding Ig like lectin 7	Homo sapiens	10-18
22911818-4	2012	METHODOLOGY/PRINCIPAL FINDINGS: Corticosteroid sensitivity was determined by measuring dexamethasone inhibition of CD3/28 and TNF-alpha induced IL-8 production in PBMCs by using ELISA.	Dexamethasone	87-100	sialic acid binding Ig like lectin 7	Homo sapiens	115-121
20663960-0	2010	Ganglioside DSGb5, preferred ligand for Siglec-7, inhibits NK cell cytotoxicity against renal cell carcinoma cells.	Gangliosides	0-11	sialic acid binding Ig like lectin 7	Homo sapiens	40-48
20663960-3	2010	Siglec-7 (sialic acid-binding Ig-like lectin-7), expressed on natural killer (NK) cells as an inhibitory receptor, has a striking preference for internally branched alpha2,6-linked disialic gangliosides such as DSGb5.	disialic gangliosides	181-202	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
20663960-3	2010	Siglec-7 (sialic acid-binding Ig-like lectin-7), expressed on natural killer (NK) cells as an inhibitory receptor, has a striking preference for internally branched alpha2,6-linked disialic gangliosides such as DSGb5.	disialic gangliosides	181-202	sialic acid binding Ig like lectin 7	Homo sapiens	10-46
20663960-7	2010	In contrast, the sialic acid-binding site of Siglec-7 on NK cells was masked by cis interactions with endogenous sialoconjugates at the cell surface, but it could be unmasked by sialidase treatment of the NK cells.	N-Acetylneuraminic Acid	17-28	sialic acid binding Ig like lectin 7	Homo sapiens	45-53
22467657-4	2012	The siglec ligand glycans in normal colonic epithelial cells included disialyl Lewis(a), which was found to have binding activity to both siglec-7 and -9, and sialyl 6-sulfo Lewis(x), which exhibited significant binding to siglec-7.	Polysaccharides	18-25	sialic acid binding Ig like lectin 7	Homo sapiens	138-153
22467657-4	2012	The siglec ligand glycans in normal colonic epithelial cells included disialyl Lewis(a), which was found to have binding activity to both siglec-7 and -9, and sialyl 6-sulfo Lewis(x), which exhibited significant binding to siglec-7.	Polysaccharides	18-25	sialic acid binding Ig like lectin 7	Homo sapiens	138-146
22467657-8	2012	Siglec-7/-9 ligation suppressed LPS-induced cyclooxygenase-2 expression and PGE(2) production by macrophages.	Dinoprostone	76-82	sialic acid binding Ig like lectin 7	Homo sapiens	0-11
20032046-1	2010	Siglec-7, a sialic acid binding immunoglobulin-like lectin, predominantly transduces inhibitory signals through cytosolic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).	Tyrosine	137-145	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
19608407-3	2009	Through sugar-specific interactions with glycan-binding proteins on apposing cells, gangliosides function as receptors in cell-cell recognition, regulating natural killer cell cytotoxicity via Siglec-7, myelin-axon interactions via Siglec-4 (myelin-associated glycoprotein), and inflammation via E-selectin.	Sugars	8-13	sialic acid binding Ig like lectin 7	Homo sapiens	193-201
19608407-3	2009	Through sugar-specific interactions with glycan-binding proteins on apposing cells, gangliosides function as receptors in cell-cell recognition, regulating natural killer cell cytotoxicity via Siglec-7, myelin-axon interactions via Siglec-4 (myelin-associated glycoprotein), and inflammation via E-selectin.	Gangliosides	84-96	sialic acid binding Ig like lectin 7	Homo sapiens	193-201
16895906-0	2006	Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b.	alpha(2,8)-disialylganglioside	73-103	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
17574526-4	2008	SPR imaging of an array of 40 sialylated and unsialylated glycans established the binding preference of hSiglec7 for alpha2-8-linked disialic acid structures over alpha2-6-sialyl-LacNAcs, which in turn were recognized and bound with greater affinity than alpha2-3-sialyl-LacNAcs.	Polysaccharides	58-65	sialic acid binding Ig like lectin 7	Homo sapiens	104-112
17574526-4	2008	SPR imaging of an array of 40 sialylated and unsialylated glycans established the binding preference of hSiglec7 for alpha2-8-linked disialic acid structures over alpha2-6-sialyl-LacNAcs, which in turn were recognized and bound with greater affinity than alpha2-3-sialyl-LacNAcs.	N-acetyllactosamine	179-186	sialic acid binding Ig like lectin 7	Homo sapiens	104-112
17574526-4	2008	SPR imaging of an array of 40 sialylated and unsialylated glycans established the binding preference of hSiglec7 for alpha2-8-linked disialic acid structures over alpha2-6-sialyl-LacNAcs, which in turn were recognized and bound with greater affinity than alpha2-3-sialyl-LacNAcs.	N-acetyllactosamine	271-278	sialic acid binding Ig like lectin 7	Homo sapiens	104-112
17574526-6	2008	The SPR imaging technique was also able to establish selective binding to the preferred glycan ligand when analyzing crude culture supernatant containing 10-20 microg of recombinant hSiglec7-Fc.	Polysaccharides	88-94	sialic acid binding Ig like lectin 7	Homo sapiens	182-190
17760270-4	2007	Disialyl Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors such as sialic acid binding immunoglobulin (Ig)-like lectins (siglec-7) and -9 expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes in digestive organs.	disialyl lewis a	0-16	sialic acid binding Ig like lectin 7	Homo sapiens	157-173
17760270-4	2007	Disialyl Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors such as sialic acid binding immunoglobulin (Ig)-like lectins (siglec-7) and -9 expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes in digestive organs.	N-Acetylneuraminic Acid	103-114	sialic acid binding Ig like lectin 7	Homo sapiens	157-173
16895906-0	2006	Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b.	gt1b	104-108	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
16895906-4	2006	We have co-crystallized Siglec-7 with a synthetic oligosaccharide corresponding to the alpha(2,8)-disialylated ganglioside GT1b.	Oligosaccharides	50-65	sialic acid binding Ig like lectin 7	Homo sapiens	24-32
16895906-4	2006	We have co-crystallized Siglec-7 with a synthetic oligosaccharide corresponding to the alpha(2,8)-disialylated ganglioside GT1b.	alpha(2,8)-disialylated ganglioside	87-122	sialic acid binding Ig like lectin 7	Homo sapiens	24-32
16895906-4	2006	We have co-crystallized Siglec-7 with a synthetic oligosaccharide corresponding to the alpha(2,8)-disialylated ganglioside GT1b.	gt1b	123-127	sialic acid binding Ig like lectin 7	Homo sapiens	24-32
16857734-9	2006	Together, these results suggest that NK cells are decorated with alpha2,8-disialic acid structures implicated in regulation of cellular activation via interactions with Siglec-7.	alpha2,8-disialic acid	65-87	sialic acid binding Ig like lectin 7	Homo sapiens	169-177
16857734-1	2006	Siglec-7 is a CD33-related sialic acid-binding Ig-like lectin expressed strongly on NK cells, where it can function as an inhibitory receptor.	N-Acetylneuraminic Acid	27-38	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
15557178-0	2004	The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells.	Tyrosine	37-45	sialic acid binding Ig like lectin 7	Homo sapiens	122-138
16857734-2	2006	Its sialic acid-binding activity on NK cells is masked by cis interactions with sialylated glycans, which are likely to be important for regulating the inhibitory function of Siglec-7, which exhibits an unusual preference for alpha2,8-linked disialic acids, a motif found in "b-series" gangliosides and some glycoproteins.	N-Acetylneuraminic Acid	4-15	sialic acid binding Ig like lectin 7	Homo sapiens	175-183
16857734-2	2006	Its sialic acid-binding activity on NK cells is masked by cis interactions with sialylated glycans, which are likely to be important for regulating the inhibitory function of Siglec-7, which exhibits an unusual preference for alpha2,8-linked disialic acids, a motif found in "b-series" gangliosides and some glycoproteins.	Polysaccharides	91-98	sialic acid binding Ig like lectin 7	Homo sapiens	175-183
16857734-2	2006	Its sialic acid-binding activity on NK cells is masked by cis interactions with sialylated glycans, which are likely to be important for regulating the inhibitory function of Siglec-7, which exhibits an unusual preference for alpha2,8-linked disialic acids, a motif found in "b-series" gangliosides and some glycoproteins.	,8-linked disialic acids	232-256	sialic acid binding Ig like lectin 7	Homo sapiens	175-183
16857734-2	2006	Its sialic acid-binding activity on NK cells is masked by cis interactions with sialylated glycans, which are likely to be important for regulating the inhibitory function of Siglec-7, which exhibits an unusual preference for alpha2,8-linked disialic acids, a motif found in "b-series" gangliosides and some glycoproteins.	Gangliosides	286-298	sialic acid binding Ig like lectin 7	Homo sapiens	175-183
16623661-0	2006	The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design.	sialosides	42-52	sialic acid binding Ig like lectin 7	Homo sapiens	17-25
16623661-4	2006	As a first step towards this end, we present the crystal structure of siglec-7 in complex with a sialylated ligand, the ganglioside analogue DSLc4 [alpha(2,3)/alpha(2,6) disialyl lactotetraosyl 2-(trimethylsilyl)ethyl], which allows for a detailed description of the binding site, required for structure-guided inhibitor design.	Gangliosides	120-131	sialic acid binding Ig like lectin 7	Homo sapiens	70-78
16623661-4	2006	As a first step towards this end, we present the crystal structure of siglec-7 in complex with a sialylated ligand, the ganglioside analogue DSLc4 [alpha(2,3)/alpha(2,6) disialyl lactotetraosyl 2-(trimethylsilyl)ethyl], which allows for a detailed description of the binding site, required for structure-guided inhibitor design.	dslc4	141-146	sialic acid binding Ig like lectin 7	Homo sapiens	70-78
16623661-4	2006	As a first step towards this end, we present the crystal structure of siglec-7 in complex with a sialylated ligand, the ganglioside analogue DSLc4 [alpha(2,3)/alpha(2,6) disialyl lactotetraosyl 2-(trimethylsilyl)ethyl], which allows for a detailed description of the binding site, required for structure-guided inhibitor design.	alpha(2,3)	148-158	sialic acid binding Ig like lectin 7	Homo sapiens	70-78
16623661-4	2006	As a first step towards this end, we present the crystal structure of siglec-7 in complex with a sialylated ligand, the ganglioside analogue DSLc4 [alpha(2,3)/alpha(2,6) disialyl lactotetraosyl 2-(trimethylsilyl)ethyl], which allows for a detailed description of the binding site, required for structure-guided inhibitor design.	alpha(2,6) disialyl lactotetraosyl 2-(trimethylsilyl)ethyl	159-217	sialic acid binding Ig like lectin 7	Homo sapiens	70-78
16623661-7	2006	A co-crystal of siglec-7 in complex with the sialoside inhibitor, oxamido-Neu5Ac [methyl alpha-9-(amino-oxalyl-amino)-9-deoxy-Neu5Ac] and inhibition data for the sialosides gives clear leads for future inhibitor design.	sialoside	45-54	sialic acid binding Ig like lectin 7	Homo sapiens	16-24
16623661-7	2006	A co-crystal of siglec-7 in complex with the sialoside inhibitor, oxamido-Neu5Ac [methyl alpha-9-(amino-oxalyl-amino)-9-deoxy-Neu5Ac] and inhibition data for the sialosides gives clear leads for future inhibitor design.	oxamido-neu5ac	66-80	sialic acid binding Ig like lectin 7	Homo sapiens	16-24
16623661-7	2006	A co-crystal of siglec-7 in complex with the sialoside inhibitor, oxamido-Neu5Ac [methyl alpha-9-(amino-oxalyl-amino)-9-deoxy-Neu5Ac] and inhibition data for the sialosides gives clear leads for future inhibitor design.	methyl alpha-9-(amino-oxalyl-amino)-9-deoxy-neu5ac	82-132	sialic acid binding Ig like lectin 7	Homo sapiens	16-24
16623661-7	2006	A co-crystal of siglec-7 in complex with the sialoside inhibitor, oxamido-Neu5Ac [methyl alpha-9-(amino-oxalyl-amino)-9-deoxy-Neu5Ac] and inhibition data for the sialosides gives clear leads for future inhibitor design.	sialosides	162-172	sialic acid binding Ig like lectin 7	Homo sapiens	16-24
15703304-2	2005	The cytoplasmic domain of Siglec-7 contains two signaling motifs: a membrane-proximal immunoreceptor tyrosine-based inhibitory motif (ITIM) (Ile435-Gln-Tyr-Ala-Pro-Leu440) and a membrane-distal motif (Asn458-Glu-Tyr-Ser-Glu-Ile463).	Tyrosine	101-109	sialic acid binding Ig like lectin 7	Homo sapiens	26-34
15703304-2	2005	The cytoplasmic domain of Siglec-7 contains two signaling motifs: a membrane-proximal immunoreceptor tyrosine-based inhibitory motif (ITIM) (Ile435-Gln-Tyr-Ala-Pro-Leu440) and a membrane-distal motif (Asn458-Glu-Tyr-Ser-Glu-Ile463).	Tyrosine	152-155	sialic acid binding Ig like lectin 7	Homo sapiens	26-34
15703304-2	2005	The cytoplasmic domain of Siglec-7 contains two signaling motifs: a membrane-proximal immunoreceptor tyrosine-based inhibitory motif (ITIM) (Ile435-Gln-Tyr-Ala-Pro-Leu440) and a membrane-distal motif (Asn458-Glu-Tyr-Ser-Glu-Ile463).	Alanine	156-159	sialic acid binding Ig like lectin 7	Homo sapiens	26-34
15703304-2	2005	The cytoplasmic domain of Siglec-7 contains two signaling motifs: a membrane-proximal immunoreceptor tyrosine-based inhibitory motif (ITIM) (Ile435-Gln-Tyr-Ala-Pro-Leu440) and a membrane-distal motif (Asn458-Glu-Tyr-Ser-Glu-Ile463).	Proline	160-163	sialic acid binding Ig like lectin 7	Homo sapiens	26-34
15703304-2	2005	The cytoplasmic domain of Siglec-7 contains two signaling motifs: a membrane-proximal immunoreceptor tyrosine-based inhibitory motif (ITIM) (Ile435-Gln-Tyr-Ala-Pro-Leu440) and a membrane-distal motif (Asn458-Glu-Tyr-Ser-Glu-Ile463).	Tyrosine	212-215	sialic acid binding Ig like lectin 7	Homo sapiens	26-34
15703304-2	2005	The cytoplasmic domain of Siglec-7 contains two signaling motifs: a membrane-proximal immunoreceptor tyrosine-based inhibitory motif (ITIM) (Ile435-Gln-Tyr-Ala-Pro-Leu440) and a membrane-distal motif (Asn458-Glu-Tyr-Ser-Glu-Ile463).	Serine	216-219	sialic acid binding Ig like lectin 7	Homo sapiens	26-34
15703304-2	2005	The cytoplasmic domain of Siglec-7 contains two signaling motifs: a membrane-proximal immunoreceptor tyrosine-based inhibitory motif (ITIM) (Ile435-Gln-Tyr-Ala-Pro-Leu440) and a membrane-distal motif (Asn458-Glu-Tyr-Ser-Glu-Ile463).	Glutamic Acid	208-211	sialic acid binding Ig like lectin 7	Homo sapiens	26-34
15557178-1	2004	Siglec-7 and Siglec-9 are two members of the recently characterized CD33-related Siglec family of sialic acid binding proteins and are both expressed on human monocytes and NK cells.	N-Acetylneuraminic Acid	98-109	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
15557178-4	2004	We first demonstrate that Siglecs-7 and -9 are able to inhibit the FcepsilonRI-mediated serotonin release from RBL cells following co-crosslinking.	Serotonin	88-97	sialic acid binding Ig like lectin 7	Homo sapiens	26-42
15557178-5	2004	In addition, we show that under these conditions or after pervanadate treatment, Siglecs-7 and -9 associate with the Src homology region 2 domain-containing phosphatases (SHP), SHP-1 and SHP-2, both in immunoprecipitation and in fluorescence microscopy experiments using GFP fusion proteins.	pervanadate	58-69	sialic acid binding Ig like lectin 7	Homo sapiens	81-97
15557178-6	2004	We then show by site-directed mutagenesis that the membrane-proximal tyrosine motif is essential for the inhibitory function of both Siglec-7 and -9, and is also required for tyrosine phosphorylation and recruitment of SHP-1 and SHP-2 phosphatases.	Tyrosine	69-77	sialic acid binding Ig like lectin 7	Homo sapiens	133-148
15557178-7	2004	Finally, mutation of the membrane-proximal motif increased the sialic acid binding activity of Siglecs-7 and -9, raising the possibility that "inside-out" signaling may occur to regulate ligand binding.	N-Acetylneuraminic Acid	63-74	sialic acid binding Ig like lectin 7	Homo sapiens	95-111
15292262-8	2004	Like all siglecs, Siglec-7 and -9 recognize sialic acid-containing glycans of glycoproteins and glycolipids as ligands.	N-Acetylneuraminic Acid	44-55	sialic acid binding Ig like lectin 7	Homo sapiens	18-33
15292262-9	2004	Mutation of the conserved Arg in the ligand binding site of Siglec-7 (Arg124) or Siglec-9 (Arg120) resulted in reduced inhibitory function in the NFAT/luciferase transcription assay, suggesting that ligand binding is required for optimal inhibition of TCR signaling.	Arginine	26-29	sialic acid binding Ig like lectin 7	Homo sapiens	60-68
12778482-0	2003	Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms.	Gangliosides	0-11	sialic acid binding Ig like lectin 7	Homo sapiens	81-89
14747738-0	2004	Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1.	Carbohydrates	17-27	sialic acid binding Ig like lectin 7	Homo sapiens	96-99
14747738-0	2004	Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1.	Carbohydrates	17-27	sialic acid binding Ig like lectin 7	Homo sapiens	100-105
14501137-1	2003	p75/AIRM1 (Siglec-7) is a sialic acid-binding Ig-like lectin recently identified as an inhibitory receptor on natural killer cells.	N-Acetylneuraminic Acid	26-37	sialic acid binding Ig like lectin 7	Homo sapiens	0-3
14501137-1	2003	p75/AIRM1 (Siglec-7) is a sialic acid-binding Ig-like lectin recently identified as an inhibitory receptor on natural killer cells.	N-Acetylneuraminic Acid	26-37	sialic acid binding Ig like lectin 7	Homo sapiens	4-9
14501137-1	2003	p75/AIRM1 (Siglec-7) is a sialic acid-binding Ig-like lectin recently identified as an inhibitory receptor on natural killer cells.	N-Acetylneuraminic Acid	26-37	sialic acid binding Ig like lectin 7	Homo sapiens	11-19
12778482-4	2003	Using synthetic polyacrylamide glycoprobes, siglec-7 was found to be masked at the NK cell surface but it could be unmasked by sialidase treatment of NK cells.	polyacrylamide glycoprobes	16-42	sialic acid binding Ig like lectin 7	Homo sapiens	44-52
11389909-0	2001	Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression.	sialogangliosides	34-53	sialic acid binding Ig like lectin 7	Homo sapiens	23-30
12639556-3	2003	Siglec-7 and siglec-9 displayed binding to gangliosides GD3, GQ1b and GT1b bearing a disialoside motif, though siglec-7 was more potent; besides, siglec-9 interacted also with GM3.	Gangliosides	43-55	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
12639556-3	2003	Siglec-7 and siglec-9 displayed binding to gangliosides GD3, GQ1b and GT1b bearing a disialoside motif, though siglec-7 was more potent; besides, siglec-9 interacted also with GM3.	disialoside	85-96	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
12639556-3	2003	Siglec-7 and siglec-9 displayed binding to gangliosides GD3, GQ1b and GT1b bearing a disialoside motif, though siglec-7 was more potent; besides, siglec-9 interacted also with GM3.	gm3	176-179	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
12639556-3	2003	Siglec-7 and siglec-9 displayed binding to gangliosides GD3, GQ1b and GT1b bearing a disialoside motif, though siglec-7 was more potent; besides, siglec-9 interacted also with GM3.	gm3	176-179	sialic acid binding Ig like lectin 7	Homo sapiens	111-119
12438315-7	2003	Comparison of the structure with that of sialoadhesin and a model of Siglec-9 shows that the unique preference of Siglec-7 for alpha(2,8)-linked disialic acid is likely to reside in the C-C" loop, which is variable in the Siglec family.	alpha(2,8)-linked disialic acid	127-158	sialic acid binding Ig like lectin 7	Homo sapiens	114-122
12438315-8	2003	In the Siglec-7 structure, the ligand-binding pocket is occupied by a loop of a symmetry-related molecule, mimicking the interactions with sialic acid.	N-Acetylneuraminic Acid	139-150	sialic acid binding Ig like lectin 7	Homo sapiens	7-15
11522302-0	2001	Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression.	sialogangliosides	34-53	sialic acid binding Ig like lectin 7	Homo sapiens	23-30
11522302-0	2001	Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression.	sialogangliosides	96-115	sialic acid binding Ig like lectin 7	Homo sapiens	23-30
11522302-3	2001	Out of other gangliosides tested, 2-->6 sialylparagloboside, GD3, GD2, and GT1b, but not other lacto- or ganglio-series gangliosides, showed clear binding to siglec7.	Gangliosides	13-25	sialic acid binding Ig like lectin 7	Homo sapiens	161-168
11522302-3	2001	Out of other gangliosides tested, 2-->6 sialylparagloboside, GD3, GD2, and GT1b, but not other lacto- or ganglio-series gangliosides, showed clear binding to siglec7.	sialosylparagloboside	43-62	sialic acid binding Ig like lectin 7	Homo sapiens	161-168
11522302-3	2001	Out of other gangliosides tested, 2-->6 sialylparagloboside, GD3, GD2, and GT1b, but not other lacto- or ganglio-series gangliosides, showed clear binding to siglec7.	gt1b	78-82	sialic acid binding Ig like lectin 7	Homo sapiens	161-168
11389909-0	2001	Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression.	sialogangliosides	96-115	sialic acid binding Ig like lectin 7	Homo sapiens	23-30
11389909-3	2001	Out of other gangliosides tested, 2-->6 sialylparagloboside, GD3, GD2, and GT1b, but not other lacto- or ganglio-series gangliosides, showed clear binding to siglec7.	Gangliosides	13-25	sialic acid binding Ig like lectin 7	Homo sapiens	161-168
11389909-3	2001	Out of other gangliosides tested, 2-->6 sialylparagloboside, GD3, GD2, and GT1b, but not other lacto- or ganglio-series gangliosides, showed clear binding to siglec7.	sialosylparagloboside	43-62	sialic acid binding Ig like lectin 7	Homo sapiens	161-168
11389909-3	2001	Out of other gangliosides tested, 2-->6 sialylparagloboside, GD3, GD2, and GT1b, but not other lacto- or ganglio-series gangliosides, showed clear binding to siglec7.	gt1b	78-82	sialic acid binding Ig like lectin 7	Homo sapiens	161-168
10567377-3	1999	Siglec-7 is predicted to contain three extracellular immunoglobulin-like domains that comprise an N-terminal V-set domain and two C2-set domains, a transmembrane region and a cytoplasmic tail containing two tyrosine residues embodied in immunoreceptor tyrosine-based inhibition motif-like motifs.	Tyrosine	207-215	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
10764831-0	2000	Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.	N-Acetylneuraminic Acid	12-23	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
10567377-3	1999	Siglec-7 is predicted to contain three extracellular immunoglobulin-like domains that comprise an N-terminal V-set domain and two C2-set domains, a transmembrane region and a cytoplasmic tail containing two tyrosine residues embodied in immunoreceptor tyrosine-based inhibition motif-like motifs.	Tyrosine	252-260	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
10567377-5	1999	When siglec-7 was expressed on COS or Chinese hamster ovary cells, it was able to mediate high levels of sialic acid-dependent binding to human erythrocytes and soluble sialoglycoconjugates, suggesting that it may be involved in cell-cell interactions.	N-Acetylneuraminic Acid	105-116	sialic acid binding Ig like lectin 7	Homo sapiens	5-13
35526487-4	2022	As Siglec-7, but not Siglec-4, is expressed on hematopoietic cells such as monocytes, the regulatory mechanism by which Siglec-7 associates with gB is important to our understanding of VZV infection of blood cells.	gb	145-147	sialic acid binding Ig like lectin 7	Homo sapiens	3-11
34878295-8	2021	Intriguingly, by using quartz crystal microbalance, we demonstrated that the PSA purified from the parent strain interacted with human sialic acid-binding immunoglobulin-like lectins (Siglecs), including Siglec-5, Siglec-7, Siglec-11, and Siglec-14.	N-Acetylneuraminic Acid	135-146	sialic acid binding Ig like lectin 7	Homo sapiens	214-222
34745101-7	2021	The comprehensive results showed that high IPI-IPM risk scores were correlated with immune-related signaling pathways, high KMT2D and CD79B mutation rates, and upregulation of inhibitory immune checkpoints, including PD-L1, BTLA, and SIGLEC7, indicating a greater potential response to ICB therapy.	diprotin A	43-46	sialic acid binding Ig like lectin 7	Homo sapiens	234-241
34215655-5	2021	This inhibitory effect on anti-CD3/28 activated T cells was observed on both CD4+ and CD8+ cells and independently of monocytes, suggesting the effects of 11.31 were directly mediated by binding to externalized PS on activated T cells.	Phosphatidylserines	211-213	sialic acid binding Ig like lectin 7	Homo sapiens	31-37
34215655-7	2021	Collectively, our findings indicate that PS-targeting mAb 11.31 suppresses cytokine production by anti-CD3/28 activated T cells.	Phosphatidylserines	41-43	sialic acid binding Ig like lectin 7	Homo sapiens	103-109
10499918-2	1999	p75/AIRM1 is a 75-kD glycoprotein that, upon sodium pervanadate treatment, becomes tyrosine phosphorylated and associates to src homology 2 domain-bearing protein tyrosine phosphatase (SHP)-1.	Sodium orthovanadate	45-63	sialic acid binding Ig like lectin 7	Homo sapiens	0-3
10499918-2	1999	p75/AIRM1 is a 75-kD glycoprotein that, upon sodium pervanadate treatment, becomes tyrosine phosphorylated and associates to src homology 2 domain-bearing protein tyrosine phosphatase (SHP)-1.	Sodium orthovanadate	45-63	sialic acid binding Ig like lectin 7	Homo sapiens	4-9
10499918-2	1999	p75/AIRM1 is a 75-kD glycoprotein that, upon sodium pervanadate treatment, becomes tyrosine phosphorylated and associates to src homology 2 domain-bearing protein tyrosine phosphatase (SHP)-1.	Tyrosine	83-91	sialic acid binding Ig like lectin 7	Homo sapiens	0-3
10499918-2	1999	p75/AIRM1 is a 75-kD glycoprotein that, upon sodium pervanadate treatment, becomes tyrosine phosphorylated and associates to src homology 2 domain-bearing protein tyrosine phosphatase (SHP)-1.	Tyrosine	83-91	sialic acid binding Ig like lectin 7	Homo sapiens	4-9
10499918-3	1999	The p75/AIRM1 gene is located on human chromosome 19 and encodes a novel member of the sialoadhesin family characterized by three immunoglobulin-like extracellular domains (one NH(2)-terminal V-type and two C2-type) and a classical immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic portion.	Tyrosine	247-255	sialic acid binding Ig like lectin 7	Homo sapiens	4-7
10499918-3	1999	The p75/AIRM1 gene is located on human chromosome 19 and encodes a novel member of the sialoadhesin family characterized by three immunoglobulin-like extracellular domains (one NH(2)-terminal V-type and two C2-type) and a classical immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic portion.	Tyrosine	247-255	sialic acid binding Ig like lectin 7	Homo sapiens	8-13
10499918-5	1999	Similar to other sialoadhesin molecules, p75/AIRM1 appears to mediate sialic acid-dependent ligand recognition.	N-Acetylneuraminic Acid	70-81	sialic acid binding Ig like lectin 7	Homo sapiens	41-44
10499918-5	1999	Similar to other sialoadhesin molecules, p75/AIRM1 appears to mediate sialic acid-dependent ligand recognition.	N-Acetylneuraminic Acid	70-81	sialic acid binding Ig like lectin 7	Homo sapiens	45-50
34425200-2	2021	Herein, we selectively introduced high affinity sialoside ligands of Siglec-1 and Siglec-7 to tumor cell surface via in vivo Strain-promoted Azide-Alkyne cyclization of TCCSiaalpha2,3-Lactose or FITCSiaalpha2,6-Lactose with 9-azido sialic acid (AzSia) metabolically installed on tumor cell surface.	sialoside	48-57	sialic acid binding Ig like lectin 7	Homo sapiens	82-90
34425200-2	2021	Herein, we selectively introduced high affinity sialoside ligands of Siglec-1 and Siglec-7 to tumor cell surface via in vivo Strain-promoted Azide-Alkyne cyclization of TCCSiaalpha2,3-Lactose or FITCSiaalpha2,6-Lactose with 9-azido sialic acid (AzSia) metabolically installed on tumor cell surface.	Azides	141-146	sialic acid binding Ig like lectin 7	Homo sapiens	82-90
34425200-2	2021	Herein, we selectively introduced high affinity sialoside ligands of Siglec-1 and Siglec-7 to tumor cell surface via in vivo Strain-promoted Azide-Alkyne cyclization of TCCSiaalpha2,3-Lactose or FITCSiaalpha2,6-Lactose with 9-azido sialic acid (AzSia) metabolically installed on tumor cell surface.	Alkynes	147-153	sialic acid binding Ig like lectin 7	Homo sapiens	82-90
34425200-2	2021	Herein, we selectively introduced high affinity sialoside ligands of Siglec-1 and Siglec-7 to tumor cell surface via in vivo Strain-promoted Azide-Alkyne cyclization of TCCSiaalpha2,3-Lactose or FITCSiaalpha2,6-Lactose with 9-azido sialic acid (AzSia) metabolically installed on tumor cell surface.	3-lactose	182-191	sialic acid binding Ig like lectin 7	Homo sapiens	82-90
34425200-2	2021	Herein, we selectively introduced high affinity sialoside ligands of Siglec-1 and Siglec-7 to tumor cell surface via in vivo Strain-promoted Azide-Alkyne cyclization of TCCSiaalpha2,3-Lactose or FITCSiaalpha2,6-Lactose with 9-azido sialic acid (AzSia) metabolically installed on tumor cell surface.	fitcsiaalpha2,6-lactose	195-218	sialic acid binding Ig like lectin 7	Homo sapiens	82-90
34425200-2	2021	Herein, we selectively introduced high affinity sialoside ligands of Siglec-1 and Siglec-7 to tumor cell surface via in vivo Strain-promoted Azide-Alkyne cyclization of TCCSiaalpha2,3-Lactose or FITCSiaalpha2,6-Lactose with 9-azido sialic acid (AzSia) metabolically installed on tumor cell surface.	9-azido sialic acid	224-243	sialic acid binding Ig like lectin 7	Homo sapiens	82-90
34425200-2	2021	Herein, we selectively introduced high affinity sialoside ligands of Siglec-1 and Siglec-7 to tumor cell surface via in vivo Strain-promoted Azide-Alkyne cyclization of TCCSiaalpha2,3-Lactose or FITCSiaalpha2,6-Lactose with 9-azido sialic acid (AzSia) metabolically installed on tumor cell surface.	azsia	245-250	sialic acid binding Ig like lectin 7	Homo sapiens	82-90
34659241-6	2021	animalis interacts with Siglecs (sialic acid-binding immunoglobulin-like lectins) expressed on innate immune cells with highest binding to Siglec-7.	N-Acetylneuraminic Acid	33-44	sialic acid binding Ig like lectin 7	Homo sapiens	139-147
35526487-4	2022	As Siglec-7, but not Siglec-4, is expressed on hematopoietic cells such as monocytes, the regulatory mechanism by which Siglec-7 associates with gB is important to our understanding of VZV infection of blood cells.	gb	145-147	sialic acid binding Ig like lectin 7	Homo sapiens	120-128
35526487-7	2022	Calcium influx in primary monocytes decreased the expression of Siglec-7 cis-ligands and increased VZV infectivity.	Calcium	0-7	sialic acid binding Ig like lectin 7	Homo sapiens	64-72
35526487-8	2022	These results demonstrate that the Siglec-7 cis-ligands present on primary monocytes play an important role in VZV infection through regulation of the interaction between gB and Siglec-7.	gb	171-173	sialic acid binding Ig like lectin 7	Homo sapiens	35-43
35526487-8	2022	These results demonstrate that the Siglec-7 cis-ligands present on primary monocytes play an important role in VZV infection through regulation of the interaction between gB and Siglec-7.	gb	171-173	sialic acid binding Ig like lectin 7	Homo sapiens	178-186
35367830-4	2022	Here, we found that Siglec-7, mainly expressed on hematopoietic cells, binds to VZV envelope glycoprotein B in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	113-124	sialic acid binding Ig like lectin 7	Homo sapiens	20-28
35149460-7	2022	Glycans with the disialoside sequence alpha(2,3)alpha(2,8)/alpha(2,6)alpha(2,8) showed high specificity and affinity for Siglec-7, and sLex alpha(2,3) exhibited a strong affinity for Siglec-9.	Polysaccharides	0-7	sialic acid binding Ig like lectin 7	Homo sapiens	121-129
35149460-7	2022	Glycans with the disialoside sequence alpha(2,3)alpha(2,8)/alpha(2,6)alpha(2,8) showed high specificity and affinity for Siglec-7, and sLex alpha(2,3) exhibited a strong affinity for Siglec-9.	disialoside	17-28	sialic acid binding Ig like lectin 7	Homo sapiens	121-129