PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34810264-0	2021	Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis.	Calcium	84-91	claudin 2	Mus musculus	0-9
24030525-7	2013	DSS-treated ClC-2 mice had increased claudin-2 expression, greater loss of occludin in the membrane, increased association of occludin with caveolin-1, and significantly increased tumor necrosis factor-alpha and interleukin-1beta messenger RNA.	dss	0-3	claudin 2	Mus musculus	37-46
34697992-6	2021	We showed that 2 weeks of Valsartan administration (30 mg/Kg body weight) mitigated the increased permeability of the brain-blood barrier and the reduction of gap junction proteins VE-Cadherin and Claudin 2.	Valsartan	26-35	claudin 2	Mus musculus	197-206
34697992-8	2021	Furthermore, Valsartan treatment recovered high glucose-repressed endothelial VE-Cadherin and Claudin 2 expression.	Valsartan	13-22	claudin 2	Mus musculus	94-103
34697992-8	2021	Furthermore, Valsartan treatment recovered high glucose-repressed endothelial VE-Cadherin and Claudin 2 expression.	Glucose	48-55	claudin 2	Mus musculus	94-103
33773208-10	2021	Treatment with either IC87114 or AMG319 not only attenuated LPS-induced edema, lung injury and neutrophilc inflammation, reduced total protein concentration and IL-6, TNF-alpha secretion in BALF, but also restored epithelial E-cadherin and claudin-2 expression.	IC 87114	22-29	claudin 2	Mus musculus	240-249
33773208-10	2021	Treatment with either IC87114 or AMG319 not only attenuated LPS-induced edema, lung injury and neutrophilc inflammation, reduced total protein concentration and IL-6, TNF-alpha secretion in BALF, but also restored epithelial E-cadherin and claudin-2 expression.	N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine	33-39	claudin 2	Mus musculus	240-249
34426115-0	2021	Terpinen4-ol inhibits heat stress induced inflammation in colonic tissue by Activating Occludin, Claudin-2 and TLR4/NF-kappaB signaling pathway.	terpinenol-4	0-12	claudin 2	Mus musculus	97-106
34663855-10	2021	In addition Claudin-2, and Occludin mRNA levels were upregulated in mice receiving chitosan on day 1, 7, and 14 of heat stress.	Chitosan	83-91	claudin 2	Mus musculus	12-21
34426115-8	2021	In addition Claudin-2, Occludin mRNA levels were upregulated in mice receiving terpinen4-ol on day 1, 7, and 14 of heat stress.	terpinenol-4	79-91	claudin 2	Mus musculus	12-21
33095778-8	2020	The mt-MRI probe consists of an antibody against claudin-2 conjugated to albumin that had Gd-DTPA (gadolinium diethylenetriamine pentaacetate) and biotin attached.	gd-dtpa	90-97	claudin 2	Mus musculus	49-58
33293626-8	2020	DXR induced increased expression of Cldn2 and Cldn4 in murine small intestine but increased only CLDN2 expression in T84 cells.	Doxorubicin	0-3	claudin 2	Mus musculus	36-41
33293626-8	2020	DXR induced increased expression of Cldn2 and Cldn4 in murine small intestine but increased only CLDN2 expression in T84 cells.	Doxorubicin	0-3	claudin 2	Mus musculus	97-102
34414236-7	2021	BE-BJO treatment improved the morphology of colon tissue, inhibited the production and release of TNF-alpha, IFN-gamma, IL-6, and IL-1beta in the colon tissue, and reversed the decreased expressions of ZO-1, occludin, claudin-1, and E-cadherin induced by DSS but augmented claudin-2 expression.	be-bjo	0-6	claudin 2	Mus musculus	273-282
35166891-4	2022	In contrast, gene encoding claudin-2 that mediates increase permeability to water and ions was upregulated in the small intestine.	Water	76-81	claudin 2	Mus musculus	27-36
33873095-12	2021	Compared with the WT-OVA + CS group, mice in the TRPA1-/--OVA + CS showed a significant decrease in the number of inflammatory cells, levels of IL-4, IL-5 and IL-13 in BALF, Penh value and lung tissue injury score, and a downregulation of Claudin-2 expression while an upregulation of ZO-1 and Occludin expressions.	Cesium	64-66	claudin 2	Mus musculus	239-248
33095778-8	2020	The mt-MRI probe consists of an antibody against claudin-2 conjugated to albumin that had Gd-DTPA (gadolinium diethylenetriamine pentaacetate) and biotin attached.	gadolinium diethylenetriamine pentaacetate	99-141	claudin 2	Mus musculus	49-58
33095778-8	2020	The mt-MRI probe consists of an antibody against claudin-2 conjugated to albumin that had Gd-DTPA (gadolinium diethylenetriamine pentaacetate) and biotin attached.	Biotin	147-153	claudin 2	Mus musculus	49-58
32784362-5	2020	SsnB administration restored a normal tight junction protein profile with an increase in Occludin and a parallel decrease in Claudin 2 and inflammatory mediators high mobility group box 1 (HMGB1), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in the distal intestine.	sparstolonin B	0-4	claudin 2	Mus musculus	125-134
32738096-7	2020	Mechanistically, butyrate induced small intestinal IL-10 expression and downregulated the claudin-2 expression.	Butyrates	17-25	claudin 2	Mus musculus	90-99
32322483-11	2020	Moreover, DSS exposure induced an increase of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, occludin, zonula occludens-1, p21, p53 and Bcl-2, and decreased the expressions of IL-10, claudin-2 and cleaved caspase-3 in the colon tissue.	Dextran Sulfate	10-13	claudin 2	Mus musculus	195-204
32489707-4	2020	Lactulose increased intestinal Claudin 2, 3 and 15, compared to the OVX group, and lowered pro-osteoclastogenic cytokines levels including tumor necrosis factor-alpha, interleukin(IL)-6, receptor activator of nuclear factor kappa-Beta ligand (RANKL), and IL-17 as well as increased the anti-inflammatory cytokine IL-10 in the intestine, peripheral blood, and bone marrow.	Lactulose	0-9	claudin 2	Mus musculus	31-40
32245617-5	2020	An increase in mRNA expression of tight junction proteins Occludin, Claudin-2 and ZO-1 provides another mechanism of restoring colonic barrier function in SA-treated group.	senokot	155-157	claudin 2	Mus musculus	68-77
32149733-3	2020	We hypothesized that claudin-2, a paracellular cation channel protein, mediates proximal tubule calcium reabsorption.	Calcium	96-103	claudin 2	Mus musculus	21-30
32092287-12	2020	The differential protein localisation of Cldn2 in the RPE during the day-night cycle suggest that Cldn2 may facilitate paracellular water and sodium transport during the day.	Water	132-137	claudin 2	Mus musculus	41-46
32092287-12	2020	The differential protein localisation of Cldn2 in the RPE during the day-night cycle suggest that Cldn2 may facilitate paracellular water and sodium transport during the day.	Water	132-137	claudin 2	Mus musculus	98-103
32092287-12	2020	The differential protein localisation of Cldn2 in the RPE during the day-night cycle suggest that Cldn2 may facilitate paracellular water and sodium transport during the day.	Sodium	142-148	claudin 2	Mus musculus	41-46
32092287-12	2020	The differential protein localisation of Cldn2 in the RPE during the day-night cycle suggest that Cldn2 may facilitate paracellular water and sodium transport during the day.	Sodium	142-148	claudin 2	Mus musculus	98-103
32149733-4	2020	We found that claudin-2-null mice have hypercalciuria due to a primary defect in renal tubule calcium transport and papillary nephrocalcinosis that resembles the intratubular plugs in kidney stone formers.	Calcium	94-101	claudin 2	Mus musculus	14-23
32149733-6	2020	Claudin-2-null mice were also found to have increased net intestinal calcium absorption, but reduced paracellular calcium permeability in the colon, suggesting that this was due to reduced intestinal calcium secretion.	Calcium	69-76	claudin 2	Mus musculus	0-9
32149733-6	2020	Claudin-2-null mice were also found to have increased net intestinal calcium absorption, but reduced paracellular calcium permeability in the colon, suggesting that this was due to reduced intestinal calcium secretion.	Calcium	114-121	claudin 2	Mus musculus	0-9
32149733-6	2020	Claudin-2-null mice were also found to have increased net intestinal calcium absorption, but reduced paracellular calcium permeability in the colon, suggesting that this was due to reduced intestinal calcium secretion.	Calcium	114-121	claudin 2	Mus musculus	0-9
32149733-9	2020	Our findings indicate that claudin-2 is a key regulator of calcium excretion and a potential target for therapies to prevent kidney stones.	Calcium	59-66	claudin 2	Mus musculus	27-36
29751049-4	2018	Claudin-2, a protein shown to be upregulated in conditions of leaky gut was significantly decreased following butyrate administration.	Butyrates	110-118	claudin 2	Mus musculus	0-9
31481470-1	2019	The tight junctional pore-forming protein claudin-2 (CLDN-2) mediates paracellular Na+ and water transport in leaky epithelia and alters cancer cell proliferation.	Water	91-96	claudin 2	Mus musculus	42-51
31481470-1	2019	The tight junctional pore-forming protein claudin-2 (CLDN-2) mediates paracellular Na+ and water transport in leaky epithelia and alters cancer cell proliferation.	Water	91-96	claudin 2	Mus musculus	53-59
30685787-10	2019	Further, downregulation of key genes for paracellular reabsorption of Ca2+ and Mg2+ (claudin (Cldn)2, Cldn10b, Cldn16, Cldn19) and for active transcellular transport of Ca2+, Mg2+, and Pi (calbindin-D28K, Ncx1, Pmca4, Cnnm2, Trpm7, NaPi-2a, and NaPi-2c) was observed.	magnesium ion	79-83	claudin 2	Mus musculus	94-100
30406698-6	2019	Zn2+ ameliorated this perturbed barrier by redistribution of claudin-2 and -4 back to the plasma membrane and by modulating the phosphorylation state of TJ proteins t hough extracellular signal-regulated kinase (ERK)1/2 dependency.	Zinc	0-4	claudin 2	Mus musculus	61-77
30406698-10	2019	Zn2+ supplementation ameliorated this barrier dysfunction, and the inflammatory response involving ERK-mediated change of phosphorylation status for claudin-2 and -4.	Zinc	0-4	claudin 2	Mus musculus	149-165
29939312-10	2019	Orally administered lactobacilli partially mitigated the CKD-induced "leaky gut"; restored colon epithelial HSP70, claudin-1 and claudin-2 expression and decreased apoptosis.	lactobacilli	20-32	claudin 2	Mus musculus	129-138
28939904-0	2017	Up-regulation of claudin-2 expression by aldosterone in colonic epithelial cells of mice fed with NaCl-depleted diets.	Sodium Chloride	98-102	claudin 2	Mus musculus	17-26
29474583-0	2018	Ochratoxin A, citrinin and deoxynivalenol decrease claudin-2 expression in mouse rectum CMT93-II cells.	ochratoxin A	0-12	claudin 2	Mus musculus	51-60
29474583-0	2018	Ochratoxin A, citrinin and deoxynivalenol decrease claudin-2 expression in mouse rectum CMT93-II cells.	Citrinin	14-22	claudin 2	Mus musculus	51-60
29474583-0	2018	Ochratoxin A, citrinin and deoxynivalenol decrease claudin-2 expression in mouse rectum CMT93-II cells.	deoxynivalenol	27-41	claudin 2	Mus musculus	51-60
28939904-2	2017	In mice fed with NaCl-depleted diets, the expression of claudin-2 and -7 increased compared to those in control mice.	Sodium Chloride	17-21	claudin 2	Mus musculus	56-72
28939904-7	2017	The ALD-induced elevation of claudin-2 mRNA and protein expression was inhibited by spironolactone, but not by RU-486, a glucocorticoid receptor antagonist.	Spironolactone	84-98	claudin 2	Mus musculus	29-38
28939904-9	2017	The binding of MR on the promoter region of claudin-2 was increased by ALD, which was inhibited by spironolactone in chromatin immunoprecipitation assay.	Spironolactone	99-113	claudin 2	Mus musculus	44-53
26041780-6	2015	45 genes were found common to both 1,25(OH)2D3-treated groups and were composed of genes previously linked to intestinal calcium uptake, including S100g, Trpv6, Atp2b1, and Cldn2 as well as others.	Calcium	121-128	claudin 2	Mus musculus	173-178
28617689-3	2017	RECENT FINDINGS: Recent studies have identified the paracellular channel, claudin-2, that is responsible for paracellular reabsorption of sodium in the proximal renal tubule.	Sodium	138-144	claudin 2	Mus musculus	74-83
28617689-4	2017	Knockout of claudin-2 in mice impairs proximal sodium and fluid reabsorption but is compensated by upregulation of sodium reabsorption in the loop of Henle.	Sodium	47-53	claudin 2	Mus musculus	12-21
28617689-4	2017	Knockout of claudin-2 in mice impairs proximal sodium and fluid reabsorption but is compensated by upregulation of sodium reabsorption in the loop of Henle.	Sodium	115-121	claudin 2	Mus musculus	12-21
28618266-4	2017	Permeability increases were limited to small molecules, as expected for the paracellular water and Na+ channel formed by claudin-2.	Water	89-94	claudin 2	Mus musculus	121-130
28618266-7	2017	Chemically induced osmotic diarrhea reduced colitis severity and C. rodentium burden in claudin-2-deficient, but not transgenic, mice, demonstrating that claudin-2-mediated protection is the result of enhanced water efflux.	Water	210-215	claudin 2	Mus musculus	154-163
26212084-3	2015	Claudin-2 is a tight junction protein that mediates paracellular water transport in intestinal epithelia, rendering them "leaky".	Water	65-70	claudin 2	Mus musculus	0-9
26212084-7	2015	We further identify a functional vitamin D response element (VDRE) 5"-AGATAACAAAGGTCA-3" in the Cdx1 site of the Claudin-2 promoter.	Vitamin D	33-42	claudin 2	Mus musculus	113-122
26212084-8	2015	It is a VDRE required for the regulation of Claudin-2 by vitamin D.	Vitamin D	57-66	claudin 2	Mus musculus	44-53
28452575-4	2017	Paracellular reabsorption of sodium occurs in the proximal tubule and is mediated by claudin-2.	Sodium	29-35	claudin 2	Mus musculus	85-94
27214555-3	2016	In the proximal tubule (PT) of the kidney, claudin-2 mediates paracellular sodium reabsorption.	Sodium	75-81	claudin 2	Mus musculus	43-52
27214555-5	2016	We found that claudin-2-null mice conserve sodium to the same extent as WT mice, even during profound dietary sodium depletion, as a result of the upregulation of transcellular Na-K-2Cl transport activity in the thick ascending limb of Henle.	Sodium	43-49	claudin 2	Mus musculus	14-23
27214555-5	2016	We found that claudin-2-null mice conserve sodium to the same extent as WT mice, even during profound dietary sodium depletion, as a result of the upregulation of transcellular Na-K-2Cl transport activity in the thick ascending limb of Henle.	Sodium	110-116	claudin 2	Mus musculus	14-23
27214555-5	2016	We found that claudin-2-null mice conserve sodium to the same extent as WT mice, even during profound dietary sodium depletion, as a result of the upregulation of transcellular Na-K-2Cl transport activity in the thick ascending limb of Henle.	na-k-2cl	177-185	claudin 2	Mus musculus	14-23
27214555-7	2016	Indeed, compared with control animals, oxygen consumption in the kidneys of claudin-2-null mice was markedly increased, resulting in medullary hypoxia.	Oxygen	39-45	claudin 2	Mus musculus	76-85
25838986-7	2015	Surprisingly, the pore-forming molecule Claudin2 revealed equal expression in TNBS-treated wild-type and IL-9-deficient animals.	Trinitrobenzenesulfonic Acid	78-82	claudin 2	Mus musculus	40-48
23971882-17	2013	Western blots showed a trend to increased claudin-1 and claudin-2 expressions in DSS mice.	dss	81-84	claudin 2	Mus musculus	56-65
25068494-11	2014	Consistent with these findings, osmotic gradient-driven water flow was significantly reduced in hepatocyte bile canaliculi and bile ducts isolated from Cldn2(-/-) mice, compared with Cldn2(+/+) mice.	Water	56-61	claudin 2	Mus musculus	152-157
25068494-14	2014	CONCLUSIONS: Based on studies of Cldn2(-/-) mice, claudin 2 regulates paracellular ion and water flow required for proper regulation of bile composition and flow.	Water	91-96	claudin 2	Mus musculus	50-59
24264043-5	2013	In the present study, the effect of dietary calcium and/or vitamin D supplementation on the expression of tight junction genes (occludin, ZO-1 and claudin 2, 10b, 12 and 15) in the duodenum of CaBP-9k- and/or -28k-deficient mice was examined.	Calcium	44-51	claudin 2	Mus musculus	147-156
24264043-5	2013	In the present study, the effect of dietary calcium and/or vitamin D supplementation on the expression of tight junction genes (occludin, ZO-1 and claudin 2, 10b, 12 and 15) in the duodenum of CaBP-9k- and/or -28k-deficient mice was examined.	Vitamin D	59-68	claudin 2	Mus musculus	147-156
23303670-0	2013	STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines.	Oxazolone	41-50	claudin 2	Mus musculus	87-96
23306855-5	2013	Moreover, in claudin-2 (-/-) mice, colitis was induced by the administration of dextran sodium sulfate (DSS).	dextran sodium sulfate	80-102	claudin 2	Mus musculus	13-22
23306855-5	2013	Moreover, in claudin-2 (-/-) mice, colitis was induced by the administration of dextran sodium sulfate (DSS).	dss	104-107	claudin 2	Mus musculus	13-22
23306855-9	2013	DSS-induced colitis was more severe in the claudin-2 (-/-) mice than in the claudin-2 (+/-) mice.	dss	0-3	claudin 2	Mus musculus	43-52
23369528-5	2013	Inhibition of the extracellular signal-regulated kinase (ERK) pathway by U0126 treatment for 24 and 48h in CMT93-II cells markedly decreased claudin-2 from the apical junctional region and increased TER.	U 0126	73-78	claudin 2	Mus musculus	141-150
23369528-7	2013	Moreover, the claudin-2 expression recovered at the apical junctional region after the removal of U0126 and TER decreased almost to the baseline level.	U 0126	98-103	claudin 2	Mus musculus	14-23
20214989-4	2010	1,25(OH)2D3 downregulates cadherin-17 and upregulates claudin-2 and claudin-12 in the intestine, suggesting that 1,25(OH)2D3, by regulating these epithelial cell junction proteins, can route calcium through the paracellular path.	Calcitriol	0-11	claudin 2	Mus musculus	54-63
20385797-6	2010	In contrast, studies in isolated, perfused S2 segments of proximal tubules showed that net transepithelial reabsorption of Na(+), Cl(-), and water was significantly decreased in Cldn2(-/-) mice and that there was an increase in paracellular shunt resistance without affecting the apical or basolateral membrane resistances.	Water	141-146	claudin 2	Mus musculus	178-183
19423758-5	2009	This similarity was also observed at genes involved in calcium homeostasis including, S100g (calbindin D9K), Trpv6, Cldn2 (claudin 2), Trpv5, and Tnfsf11 (Rankl) as well as Cyp24a1.	Calcium	55-62	claudin 2	Mus musculus	116-121
20385797-1	2010	Claudin-2 is highly expressed in tight junctions of mouse renal proximal tubules, which possess a leaky epithelium whose unique permeability properties underlie their high rate of NaCl reabsorption.	Sodium Chloride	180-184	claudin 2	Mus musculus	0-9
19423758-5	2009	This similarity was also observed at genes involved in calcium homeostasis including, S100g (calbindin D9K), Trpv6, Cldn2 (claudin 2), Trpv5, and Tnfsf11 (Rankl) as well as Cyp24a1.	Calcium	55-62	claudin 2	Mus musculus	123-132
15569684-10	2005	U0126 treatment also induced claudin-2 expression and decreased TER in a high resistance mouse cortical collecting duct cell line (94D).	U 0126	0-5	claudin 2	Mus musculus	29-38
15308585-10	2004	In Raf-1-transfected cells treated with PD98059 and SB203580, but not LY294002, expression and localization of claudin-2, but not occludin, recovered, together with barrier function, measured as the TER value.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	40-47	claudin 2	Mus musculus	111-120
15308585-10	2004	In Raf-1-transfected cells treated with PD98059 and SB203580, but not LY294002, expression and localization of claudin-2, but not occludin, recovered, together with barrier function, measured as the TER value.	SB 203580	52-60	claudin 2	Mus musculus	111-120