PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 33159835-9 2020 Atg16l1 knockout in CD11c+ DCs exacerbated intestinal inflammation of dextran sulfate sodium (DSS)-induced colitis in vivo. Dextran Sulfate 70-92 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 0-7 33159835-9 2020 Atg16l1 knockout in CD11c+ DCs exacerbated intestinal inflammation of dextran sulfate sodium (DSS)-induced colitis in vivo. Dextran Sulfate 94-97 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 0-7 33159835-11 2020 Bacterial translocation showed that bacteria amount in MLN and stool of DSS-induced colitis with Atg16l1 deficiency significantly higher than that of control. Dextran Sulfate 72-75 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 97-104 33159835-13 2020 We confirmed that Atg16l1 deficiency in DCs exacerbated the intestinal inflammation of DSS-induced colitis. Dextran Sulfate 87-90 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 18-25 33159835-14 2020 Atg16l1 deficiency in DCs promotes the bacterial translocation of DSS-induced colitis in vivo and regulates autophagy and phagocytosis in BMDCs. Dextran Sulfate 66-69 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 0-7 31919280-6 2020 These findings elucidate the NOD2-mediated mechanism of cytoprotection involving the clearance of the lethal excess of ROS molecules through mitophagy, triggered by the coordinated activation of NOD2 and ATG16L1 by a nuclear factor kappaB (NF-kappaB)-independent pathway. Reactive Oxygen Species 119-122 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 204-211 29965781-10 2018 Furthermore, RAB26 was involved in a direct and activation-dependent manner in autophagy induction through interaction with ATG16L1 in its GTP-bound form. Guanosine Triphosphate 139-142 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 124-131 31361973-12 2019 In the organoids and colitis IL-10-/- mice, vitamin D3 treatment increased VDR and ATG16L1 protein expression levels, which activated autophagic responses. Cholecalciferol 44-54 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 83-90 31488728-5 2019 Curcumin treatment significantly increased the expression of Beclin1, Atg5, and Atg16L1, induced the formation of autophagosomes, and promoted autophagosome-lysosome fusion in N2a/APP695swe cells. Curcumin 0-8 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 80-87 30137026-7 2018 Pharmacologic intervention by either apoptosis inhibitor or PPARgamma agonist rosiglitazone prevented smoking-induced crypt apoptosis and Paneth cell defects in T300A mice and mice with conditional Paneth cell-specific knockout of Atg16l1. Rosiglitazone 78-91 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 231-238 29996716-7 2018 In contrast, we found that trehalose action on thermogenesis was independent of LEP (leptin) and the autophagy pathway, as there was robust thermogenic induction in trehalose-treated ob/ob, Becn1, Atg16l1, and Epg5 mutant mice. Trehalose 27-36 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 197-204 29996716-7 2018 In contrast, we found that trehalose action on thermogenesis was independent of LEP (leptin) and the autophagy pathway, as there was robust thermogenic induction in trehalose-treated ob/ob, Becn1, Atg16l1, and Epg5 mutant mice. Trehalose 165-174 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 197-204 28390705-10 2017 Mechanistic studies performed in primary murine BMDCs showed that Atg16l1 deficiency increased ROS production, reduced microbial killing and impaired antigen processing for altered intracellular trafficking. Reactive Oxygen Species 95-98 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 66-73 23973919-11 2013 Atg16l1(f/f) x Villin-cre mice also had fewer Paneth cells and abnormal granule morphology, leading to reduced expression of AMPs. Adenylyl sulfate 125-129 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 0-7 28591717-11 2017 Thus, peretinoin prevents the progression of NASH and the development of HCC through activating the autophagy pathway by increased Atg16L1 expression, which is an essential regulator of autophagy and anti-inflammatory proteins. (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid 6-16 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 131-138 28130498-4 2017 Mechanistic analyses using primary murine macrophages showed that Atg16l1 deficiency led to increased reactive oxygen species production, impaired mitophagy, reduced microbial killing, impaired processing of MHC class II Ags, and altered intracellular trafficking to the lysosomal compartments. Reactive Oxygen Species 102-125 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 66-73 28130498-5 2017 Increased production of reactive oxygen species and reduced microbial killing may be general features of the myeloid compartment, as they were also observed in Atg16l1-deficient primary murine neutrophils. Reactive Oxygen Species 24-47 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 160-167 26975471-6 2016 Moreover, the results reported here suggest that Arg-24 of Atg16L1 is crucial for its interaction with Atg5 which will have further implication in the binding of the dimeric complex to Rab33B. Arginine 49-52 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 59-66 25597631-4 2015 Lipidomic analysis of annexin A2-deficient mouse cells indicates that this protein plays a role in recruiting phosphatidylserine and phosphatidylinositides to Atg16L-positive vesicles. Phosphatidylserines 110-128 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 159-165 25597631-4 2015 Lipidomic analysis of annexin A2-deficient mouse cells indicates that this protein plays a role in recruiting phosphatidylserine and phosphatidylinositides to Atg16L-positive vesicles. phosphatidylinositides 133-155 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 159-165 25893854-6 2015 Furthermore, administration of a lower dose (2 mg/kg) of elaiophylin as a single agent achieves a significant antitumor effect without toxicity in an orthotopic ovarian cancer model with metastasis; however, high doses (8 mg/kg) of elaiophylin lead to dysfunction of Paneth cells, which resembles the intestinal phenotype of ATG16L1-deficient mice. elaiophylin 57-68 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 325-332 27063951-4 2016 Cell culture study showed that UA enhanced autophagy of macrophages by increasing the expression of Atg5 and Atg16l1, which led to altered macrophage function. ursolic acid 31-33 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 109-116 18849965-9 2008 Mice lacking Atg16L1 in haematopoietic cells are highly susceptible to dextran sulphate sodium-induced acute colitis, which is alleviated by injection of anti-IL-1beta and IL-18 antibodies, indicating the importance of Atg16L1 in the suppression of intestinal inflammation. dextran sulphate sodium 71-94 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 13-20 23295687-8 2012 Interestingly, the phenotype of aberrant Paneth cells and dextran sodium sulphate-induced colitis in ATG16L1 hypomorphic mice closely resembles human CD. dextran sodium sulphate 58-81 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 101-108 34619495-7 2021 Furthermore, miR-142-3p negatively-regulated expression of ATG16L1 and ATG4c by directly targeting its 3"-UTR, and meaningfully abated the level of autophagy. mir-142-3p 13-23 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 59-66 34619495-8 2021 CONCLUSION: These findings suggested that miR-142-3p inhibited M. tuberculosis-induced activation of autophagy and promoted H37Ra survival in RAW264.7 cells by targeting ATG16L1 and ATG4c. mir-142-3p 42-52 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 170-177 34381417-0 2021 MicroRNA 223 Targeting ATG16L1 Affects Microglial Autophagy in the Kainic Acid Model of Temporal Lobe Epilepsy. Kainic Acid 67-78 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 23-30 34381417-1 2021 This study aimed to explore whether microRNA (miR) 223 affects microglial autophagy by targeting autophagy-related 16-like 1 (ATG16L1) in the kainic acid (KA) model of temporal lobe epilepsy (TLE). Kainic Acid 142-153 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 97-124 34381417-1 2021 This study aimed to explore whether microRNA (miR) 223 affects microglial autophagy by targeting autophagy-related 16-like 1 (ATG16L1) in the kainic acid (KA) model of temporal lobe epilepsy (TLE). Kainic Acid 142-153 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 126-133 34381417-10 2021 Treatment with antagomir 223 alleviated epilepsy, prevented abnormalities in EEG recordings and increased the ATG16L1 and LC3 levels in KA-treated mice. Antagomirs 15-24 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 110-117 35220902-5 2022 Thus, by identifying that autophagy is a pathway-intrinsic homeostatic mechanism that restricts excessive TLR- or NLR-mediated inflammatory signaling, our findings shed new light on how the ATG16L1T300A polymorphism sets the stage for the occurrence of Crohn disease.Abbreviations: 3-MA: 3-methyladenine; ATG16L1: autophagy related 16 like 1; ATG7: autophagy related 7; BMDM: bone marrow-derived macrophage; CD: Crohn disease; CXCL: C-X-C motif chemokine ligand; IBD: inflammatory bowel disease; iBMDM: immortalized mouse BMDM; IL1B/IL-1beta: interleukin 1 beta; IL6: interleukin 6; KI: knockin; KO: knockout; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; LPS: lipopolysaccharide; MDP: muramyl dipeptide; MEF: mouse embryonic fibroblast; NFKB/NF-kappaB: nuclear factor kappa B; NFKBIA/IKBA: NFKB inhibitor alpha; NLR: NOD-like receptor; NOD: nucleotide-binding oligomerization domain containing; RIPK2: receptor interacting serine/threonine kinase 2; SNP: single nucleotide polymorphism; SQSTM1/p62: sequestosome 1; TLR: toll like receptor; TNF/TNF-alpha: tumor necrosis factor; TRAF6: TNF receptor associated factor 6; Ub: ubiquitin; WT: wild type. Serine 939-945 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 190-197 34085925-6 2021 Quantitative multiplexed proteomics of murine bone marrow-derived macrophages revealed that ATG16L1 deficiency significantly upregulated proteins involved in the glutathione-mediated antioxidant response to compensate for elevated oxidative stress, which simultaneously promoted S.flexneri killing. Glutathione 162-173 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 92-99 33396170-5 2021 Also, over-exposure to Cu increased mRNA and protein expressions of Beclin1, Atg12, Atg5, Atg16L1, Atg7, Atg3, and LC3 and decreased mRNA and protein expressions of p62. Copper 23-25 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 90-97 33670592-7 2021 In addition, the reactive oxygen species (ROS)-NOD2-autophagy related 16 like 1 (ATG16L) signaling pathway may be involved in the blue-light-induced autophagy responses, resulting in corneal epithelial apoptosis. Reactive Oxygen Species 17-40 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 81-87 33670592-7 2021 In addition, the reactive oxygen species (ROS)-NOD2-autophagy related 16 like 1 (ATG16L) signaling pathway may be involved in the blue-light-induced autophagy responses, resulting in corneal epithelial apoptosis. Reactive Oxygen Species 42-45 autophagy related 16-like 1 (S. cerevisiae) Mus musculus 81-87