PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
30865735-4	2019	In vitro alpha-glucosidase inhibitory assay verified that quercetin-3-O-glucuronide, kaempferol-3-O-rhamnoside, quercetin, kaempferol, asiatic acid and genistein were primarily responsible for the alpha-glucosidase inhibitory activity of the CP extract.	quercetin 3-O-glucuronide	58-83	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
31195972-1	2019	BACKGROUND: Treatment with the alpha-glucosidase inhibitor acarbose increases median lifespan by approximately 20% in male mice and 5% in females.	Acarbose	59-67	sucrase isomaltase (alpha-glucosidase)	Mus musculus	31-48
33405753-5	2019	Herein, SIS was recross-linked by a four-arm polyethylene glycol (fa-PEG) with succinimidyl glutarate-terminated branches into a three-dimensional (3D) bioactive sponge (SIS-PEG), which possessed porous 3D frameworks to mimic the structure of skin.	Polyethylene Glycols	45-64	sucrase isomaltase (alpha-glucosidase)	Mus musculus	8-11
33405753-5	2019	Herein, SIS was recross-linked by a four-arm polyethylene glycol (fa-PEG) with succinimidyl glutarate-terminated branches into a three-dimensional (3D) bioactive sponge (SIS-PEG), which possessed porous 3D frameworks to mimic the structure of skin.	fa-peg	66-72	sucrase isomaltase (alpha-glucosidase)	Mus musculus	8-11
33405753-5	2019	Herein, SIS was recross-linked by a four-arm polyethylene glycol (fa-PEG) with succinimidyl glutarate-terminated branches into a three-dimensional (3D) bioactive sponge (SIS-PEG), which possessed porous 3D frameworks to mimic the structure of skin.	succinimidyl glutarate	79-101	sucrase isomaltase (alpha-glucosidase)	Mus musculus	8-11
33405753-6	2019	The addition of a suitable proportion of fa-PEG endowed SIS with a uniform pore size, outstanding bioactivity, and flexible shape to promote a rapid healing of a mouse skin defect.	Polyethylene Glycols	44-47	sucrase isomaltase (alpha-glucosidase)	Mus musculus	56-59
33405753-7	2019	Compared with SIS, the bioactive SIS-PEG sponge exhibited excellent mechanical stability and was less prone to collagenase degradation.	Polyethylene Glycols	37-40	sucrase isomaltase (alpha-glucosidase)	Mus musculus	33-36
30865735-4	2019	In vitro alpha-glucosidase inhibitory assay verified that quercetin-3-O-glucuronide, kaempferol-3-O-rhamnoside, quercetin, kaempferol, asiatic acid and genistein were primarily responsible for the alpha-glucosidase inhibitory activity of the CP extract.	kaempferol 3-O-rhamnoside	85-110	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
30865735-4	2019	In vitro alpha-glucosidase inhibitory assay verified that quercetin-3-O-glucuronide, kaempferol-3-O-rhamnoside, quercetin, kaempferol, asiatic acid and genistein were primarily responsible for the alpha-glucosidase inhibitory activity of the CP extract.	Quercetin	58-67	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
30865735-4	2019	In vitro alpha-glucosidase inhibitory assay verified that quercetin-3-O-glucuronide, kaempferol-3-O-rhamnoside, quercetin, kaempferol, asiatic acid and genistein were primarily responsible for the alpha-glucosidase inhibitory activity of the CP extract.	kaempferol	85-95	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
30865735-4	2019	In vitro alpha-glucosidase inhibitory assay verified that quercetin-3-O-glucuronide, kaempferol-3-O-rhamnoside, quercetin, kaempferol, asiatic acid and genistein were primarily responsible for the alpha-glucosidase inhibitory activity of the CP extract.	asiatic acid	135-147	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
30865735-4	2019	In vitro alpha-glucosidase inhibitory assay verified that quercetin-3-O-glucuronide, kaempferol-3-O-rhamnoside, quercetin, kaempferol, asiatic acid and genistein were primarily responsible for the alpha-glucosidase inhibitory activity of the CP extract.	Genistein	152-161	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
30865735-6	2019	Moreover, the molecular docking study revealed that these identified alpha-glucosidase inhibitors more easily occupy the active sites of alpha-glucosidase than does the positive control acarbose.	Acarbose	186-194	sucrase isomaltase (alpha-glucosidase)	Mus musculus	69-86
30865735-6	2019	Moreover, the molecular docking study revealed that these identified alpha-glucosidase inhibitors more easily occupy the active sites of alpha-glucosidase than does the positive control acarbose.	Acarbose	186-194	sucrase isomaltase (alpha-glucosidase)	Mus musculus	137-154
30648298-0	2019	Pheophorbide A from Gelidium amansii improves postprandial hyperglycemia in diabetic mice through alpha-glucosidase inhibition.	pheophorbide a	0-14	sucrase isomaltase (alpha-glucosidase)	Mus musculus	98-115
30785285-0	2019	Resveratroloside Alleviates Postprandial Hyperglycemia in Diabetic Mice by Competitively Inhibiting alpha-Glucosidase.	3,5,4'-trihydroxystilbene-4'-O-glucoside	0-16	sucrase isomaltase (alpha-glucosidase)	Mus musculus	100-117
30785285-6	2019	Further analyses demonstrated that resveratroloside strongly and effectively inhibited alpha-glucosidase, with an 50% inhibitory concentration value of 22.9 +- 0.17 muM, and its inhibition was significantly stronger than those of acarbose and resveratrol (264 +- 3.27 and 108 +- 2.13 muM).	3,5,4'-trihydroxystilbene-4'-O-glucoside	35-51	sucrase isomaltase (alpha-glucosidase)	Mus musculus	87-104
30785285-6	2019	Further analyses demonstrated that resveratroloside strongly and effectively inhibited alpha-glucosidase, with an 50% inhibitory concentration value of 22.9 +- 0.17 muM, and its inhibition was significantly stronger than those of acarbose and resveratrol (264 +- 3.27 and 108 +- 2.13 muM).	Acarbose	230-238	sucrase isomaltase (alpha-glucosidase)	Mus musculus	87-104
30785285-6	2019	Further analyses demonstrated that resveratroloside strongly and effectively inhibited alpha-glucosidase, with an 50% inhibitory concentration value of 22.9 +- 0.17 muM, and its inhibition was significantly stronger than those of acarbose and resveratrol (264 +- 3.27 and 108 +- 2.13 muM).	Resveratrol	35-46	sucrase isomaltase (alpha-glucosidase)	Mus musculus	87-104
30785285-7	2019	Moreover, a competitive inhibition mechanism of resveratroloside on alpha-glucosidase was determined by enzyme kinetic assays and molecular docking experiments.	3,5,4'-trihydroxystilbene-4'-O-glucoside	48-64	sucrase isomaltase (alpha-glucosidase)	Mus musculus	68-85
30785285-8	2019	The molecular docking of resveratroloside with alpha-glucosidase demostrated the competitive inhibitory effect of resveratroloside, which occupies the catalytic site and forms strong hydrogen bonds with the residues of alpha-glucosidase.	3,5,4'-trihydroxystilbene-4'-O-glucoside	25-41	sucrase isomaltase (alpha-glucosidase)	Mus musculus	47-64
30785285-8	2019	The molecular docking of resveratroloside with alpha-glucosidase demostrated the competitive inhibitory effect of resveratroloside, which occupies the catalytic site and forms strong hydrogen bonds with the residues of alpha-glucosidase.	3,5,4'-trihydroxystilbene-4'-O-glucoside	25-41	sucrase isomaltase (alpha-glucosidase)	Mus musculus	219-236
30785285-8	2019	The molecular docking of resveratroloside with alpha-glucosidase demostrated the competitive inhibitory effect of resveratroloside, which occupies the catalytic site and forms strong hydrogen bonds with the residues of alpha-glucosidase.	3,5,4'-trihydroxystilbene-4'-O-glucoside	114-130	sucrase isomaltase (alpha-glucosidase)	Mus musculus	47-64
30785285-8	2019	The molecular docking of resveratroloside with alpha-glucosidase demostrated the competitive inhibitory effect of resveratroloside, which occupies the catalytic site and forms strong hydrogen bonds with the residues of alpha-glucosidase.	3,5,4'-trihydroxystilbene-4'-O-glucoside	114-130	sucrase isomaltase (alpha-glucosidase)	Mus musculus	219-236
30785285-8	2019	The molecular docking of resveratroloside with alpha-glucosidase demostrated the competitive inhibitory effect of resveratroloside, which occupies the catalytic site and forms strong hydrogen bonds with the residues of alpha-glucosidase.	Hydrogen	183-191	sucrase isomaltase (alpha-glucosidase)	Mus musculus	47-64
30785285-8	2019	The molecular docking of resveratroloside with alpha-glucosidase demostrated the competitive inhibitory effect of resveratroloside, which occupies the catalytic site and forms strong hydrogen bonds with the residues of alpha-glucosidase.	Hydrogen	183-191	sucrase isomaltase (alpha-glucosidase)	Mus musculus	219-236
30785285-9	2019	Resveratrol was also determined to be a competitive inhibition mechanism on alpha-glucosidase by enzyme kinetic assays and molecular docking experiments.	Resveratrol	0-11	sucrase isomaltase (alpha-glucosidase)	Mus musculus	76-93
30648298-2	2019	Pheophorbide A caused noticeable inhibitory effects on alpha-glucosidase and alpha-amylase, with half-maximal inhibitory concentrations (IC50 ) of 80.65 +- 5.90 and 76.48 +- 6.31 muM, respectively.	pheophorbide a	0-14	sucrase isomaltase (alpha-glucosidase)	Mus musculus	55-72
30648298-3	2019	The pheophorbide-mediated inhibition of alpha-glucosidase and alpha-amylase was significantly more effective than that of the positive control, acarbose.	pheophorbide	4-16	sucrase isomaltase (alpha-glucosidase)	Mus musculus	40-57
30788051-10	2019	RESULTS: In vitro inhibitory effect of AOB extract on alpha-glucosidase was 92% as strong as that of acarbose.	(E)-2-Amino-4-Oxo-6-Styryl-4,7-Dihydro-3h-Pyrrolo[2,3-D]pyrimidine-5-Carbonitrile	39-42	sucrase isomaltase (alpha-glucosidase)	Mus musculus	54-71
30677669-0	2019	Synthesis and biological evaluation of novel oleanolic acid analogues as potential alpha-glucosidase inhibitors.	Oleanolic Acid	45-59	sucrase isomaltase (alpha-glucosidase)	Mus musculus	83-100
30677669-2	2019	In this study, a series of novel oleanolic acid analogues against alpha-glucosidase were synthesized and their biological activities were evaluated in vitro and in vivo.	Oleanolic Acid	33-47	sucrase isomaltase (alpha-glucosidase)	Mus musculus	66-83
30677669-5	2019	Moreover, the docking studies were carried out to prove that the four compounds could interact with the hydrophobic region of the active pocket and form hydrogen bonds to enhance the binding affinity of them with the alpha-glucosidase.	Hydrogen	153-161	sucrase isomaltase (alpha-glucosidase)	Mus musculus	217-234
31353663-0	2019	Rosmarinic acid and its ester derivatives for enhancing antibacterial, alpha-glucosidase inhibitory, and lipid accumulation suppression activities.	rosmarinic acid	0-15	sucrase isomaltase (alpha-glucosidase)	Mus musculus	71-88
31353663-0	2019	Rosmarinic acid and its ester derivatives for enhancing antibacterial, alpha-glucosidase inhibitory, and lipid accumulation suppression activities.	Esters	24-29	sucrase isomaltase (alpha-glucosidase)	Mus musculus	71-88
31353663-2	2019	To expand its application, RA was modified by esterification with methyl (me), propyl (pro), and hexyl (hex) alcohols and then tested antibacterial, alpha-glucosidase inhibitory, and lipid accumulation suppression activities.	rosmarinic acid	27-29	sucrase isomaltase (alpha-glucosidase)	Mus musculus	149-166
31353663-4	2019	RA-hex also inhibited alpha-glucosidase inhibitory activity greater than luteolin.	ra-hex	0-6	sucrase isomaltase (alpha-glucosidase)	Mus musculus	22-39
31353663-5	2019	By computational molecular docking, dihydroxyphenyl group and hexyl group were selected as essential groups for interaction with the active site of alpha-glucosidase through hydrogen bonding and hydrophobic interaction, contributing to the great inhibitory activity.	dipicrylamine	62-67	sucrase isomaltase (alpha-glucosidase)	Mus musculus	148-165
31353663-5	2019	By computational molecular docking, dihydroxyphenyl group and hexyl group were selected as essential groups for interaction with the active site of alpha-glucosidase through hydrogen bonding and hydrophobic interaction, contributing to the great inhibitory activity.	Hydrogen	174-182	sucrase isomaltase (alpha-glucosidase)	Mus musculus	148-165
31353663-12	2019	In this study, RA was derivatized to corresponding ester such as methyl, propyl, and hexyl alcohols with higher hydrophobicity, and found great antibacterial, alpha-glucosidase inhibitory, and lipid accumulation suppression activities.	rosmarinic acid	15-17	sucrase isomaltase (alpha-glucosidase)	Mus musculus	159-176
31353663-12	2019	In this study, RA was derivatized to corresponding ester such as methyl, propyl, and hexyl alcohols with higher hydrophobicity, and found great antibacterial, alpha-glucosidase inhibitory, and lipid accumulation suppression activities.	methyl, propyl, and hexyl alcohols	65-99	sucrase isomaltase (alpha-glucosidase)	Mus musculus	159-176
30171943-7	2018	Further, crude polysaccharide CYS-1 (>=80 mug/mL) had a good ability of inhibiting alpha-glucosidase and significant inhibition on the relative proliferation rate of B16 murine melanoma cells middle dose (>=200 mug/mL).	Polysaccharides	15-29	sucrase isomaltase (alpha-glucosidase)	Mus musculus	86-103
30663749-0	2019	New flavonoids from the Saudi Arabian plant Retama raetam which stimulates secretion of insulin and inhibits alpha-glucosidase.	Flavonoids	4-14	sucrase isomaltase (alpha-glucosidase)	Mus musculus	109-126
30663749-6	2019	Five new examples (two flavones and three isoflavones) strongly enhanced the glucose-triggered release of insulin by murine pancreatic islets and one isoflavone was a potent inhibitor of alpha-glucosidase.	Flavones	23-31	sucrase isomaltase (alpha-glucosidase)	Mus musculus	187-204
30663749-6	2019	Five new examples (two flavones and three isoflavones) strongly enhanced the glucose-triggered release of insulin by murine pancreatic islets and one isoflavone was a potent inhibitor of alpha-glucosidase.	Isoflavones	42-53	sucrase isomaltase (alpha-glucosidase)	Mus musculus	187-204
30427356-3	2018	HDBPs (crude Huidouba polysaccharide (CHDBP), HDBP-1 and HDBP-2) exhibited significant antioxidant and alpha-glucosidase inhibitory activities in vitro.	Polysaccharides	22-36	sucrase isomaltase (alpha-glucosidase)	Mus musculus	103-120
30427356-3	2018	HDBPs (crude Huidouba polysaccharide (CHDBP), HDBP-1 and HDBP-2) exhibited significant antioxidant and alpha-glucosidase inhibitory activities in vitro.	chdbp	38-43	sucrase isomaltase (alpha-glucosidase)	Mus musculus	103-120
30403167-2	2018	METHODS: In this study, the water extract of LWDH was tested for its alpha-Amylase and alpha-Glucosidase inhibitory activities, and its anti-diabetic property in streptozotocin (STZ)-induced diabetic mice was also analyzed.	Water	28-33	sucrase isomaltase (alpha-glucosidase)	Mus musculus	87-104
30397537-7	2018	Methods: Carbohydrate digestion by intestinal disaccharidases (sucrase-isomaltase and maltase-glucoamylase) was evaluated ex vivo in mice gavaged with 1 or 4 doses of PVF.	Carbohydrates	9-21	sucrase isomaltase (alpha-glucosidase)	Mus musculus	63-81
30375449-4	2018	Sunrouge also strongly inhibited the carbohydrate-hydrolyzing enzymes alpha-glucosidase and alpha-amylase when compared with that of Yabukita and many other cultivars.	Carbohydrates	37-49	sucrase isomaltase (alpha-glucosidase)	Mus musculus	70-87
30375449-7	2018	Analysis of metabolites, contributing to the discrimination and prediction of the bioactivity of cultivars, showed that O-methylated catechins, epicatechin-3-O-(3-O-methyl) gallate (ECG3"Me) and epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me), were newly identified alpha-glucosidase inhibitors.	Catechin	133-142	sucrase isomaltase (alpha-glucosidase)	Mus musculus	271-288
30246823-0	2018	Roasting improves the hypoglycemic effects of a large-leaf yellow tea infusion by enhancing the levels of epimerized catechins that inhibit alpha-glucosidase.	Catechin	117-126	sucrase isomaltase (alpha-glucosidase)	Mus musculus	140-157
30246823-5	2018	Of the two main alpha-glucosidase inhibitors, GCG exhibited a higher inhibitory effect on alpha-glucosidase than its corresponding epimer (EGCG), whose IC50 value was about 3-fold lower.	gallocatechin gallate	46-49	sucrase isomaltase (alpha-glucosidase)	Mus musculus	16-33
30246823-5	2018	Of the two main alpha-glucosidase inhibitors, GCG exhibited a higher inhibitory effect on alpha-glucosidase than its corresponding epimer (EGCG), whose IC50 value was about 3-fold lower.	gallocatechin gallate	46-49	sucrase isomaltase (alpha-glucosidase)	Mus musculus	90-107
30246823-6	2018	Modeling of molecular docking suggested that GCG preferably binds to the target alpha-glucosidase protein; this was confirmed by in vitro protein-polyphenol binding, where GCG had a binding rate about 4 times higher than that of EGCG.	gallocatechin gallate	45-48	sucrase isomaltase (alpha-glucosidase)	Mus musculus	80-97
30246823-6	2018	Modeling of molecular docking suggested that GCG preferably binds to the target alpha-glucosidase protein; this was confirmed by in vitro protein-polyphenol binding, where GCG had a binding rate about 4 times higher than that of EGCG.	Polyphenols	146-156	sucrase isomaltase (alpha-glucosidase)	Mus musculus	80-97
30246823-6	2018	Modeling of molecular docking suggested that GCG preferably binds to the target alpha-glucosidase protein; this was confirmed by in vitro protein-polyphenol binding, where GCG had a binding rate about 4 times higher than that of EGCG.	gallocatechin gallate	172-175	sucrase isomaltase (alpha-glucosidase)	Mus musculus	80-97
30246823-6	2018	Modeling of molecular docking suggested that GCG preferably binds to the target alpha-glucosidase protein; this was confirmed by in vitro protein-polyphenol binding, where GCG had a binding rate about 4 times higher than that of EGCG.	epigallocatechin gallate	229-233	sucrase isomaltase (alpha-glucosidase)	Mus musculus	80-97
30183039-4	2018	Molecular simulation results demonstrated that EGCG could bind to the active site of alpha-amylase and alpha-glucosidase, acting as an inhibitor.	epigallocatechin gallate	47-51	sucrase isomaltase (alpha-glucosidase)	Mus musculus	103-120
30188554-0	2018	Proanthocyanidin B2 attenuates postprandial blood glucose and its inhibitory effect on alpha-glucosidase: analysis by kinetics, fluorescence spectroscopy, atomic force microscopy and molecular docking.	procyanidin B2	0-19	sucrase isomaltase (alpha-glucosidase)	Mus musculus	87-104
30189596-6	2018	Taken altogether, in vitro and in vivo experiments suggest that selected natural compounds (curcumin, antroquinonol, HCD, docosanol, tetracosanol, rutin, and actinodaphnine) via molecular docking were confirmed as potential candidates of alpha-glucosidase and alpha-amylase inhibitors for treating diabetes.	Curcumin	92-100	sucrase isomaltase (alpha-glucosidase)	Mus musculus	238-255
30031794-0	2018	Scopoletin inhibits alpha-glucosidase in vitro and alleviates postprandial hyperglycemia in mice with diabetes.	Scopoletin	0-10	sucrase isomaltase (alpha-glucosidase)	Mus musculus	20-37
30031794-1	2018	The aim of this study was to investigate whether scopoletin could inhibit the activities of the carbohydrate digestive enzymes, alpha-glucosidase and alpha-amylase, and reduce postprandial hyperglycemia in streptozotocin (STZ)-induced diabetes in mice.	Scopoletin	49-59	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
30031794-2	2018	Scopoletin showed a distinct inhibitory effect on alpha-glucosidase and alpha-amylase.	Scopoletin	0-10	sucrase isomaltase (alpha-glucosidase)	Mus musculus	50-67
30031794-3	2018	The half maximal inhibitory concentration (IC50) of scopoletin was 85.12 and 37.36 muM for alpha-glucosidase and alpha-amylase, respectively, which were lower values than those for acarbose.	Scopoletin	52-62	sucrase isomaltase (alpha-glucosidase)	Mus musculus	91-108
30189596-6	2018	Taken altogether, in vitro and in vivo experiments suggest that selected natural compounds (curcumin, antroquinonol, HCD, docosanol, tetracosanol, rutin, and actinodaphnine) via molecular docking were confirmed as potential candidates of alpha-glucosidase and alpha-amylase inhibitors for treating diabetes.	antroquinonol	102-115	sucrase isomaltase (alpha-glucosidase)	Mus musculus	238-255
30189596-6	2018	Taken altogether, in vitro and in vivo experiments suggest that selected natural compounds (curcumin, antroquinonol, HCD, docosanol, tetracosanol, rutin, and actinodaphnine) via molecular docking were confirmed as potential candidates of alpha-glucosidase and alpha-amylase inhibitors for treating diabetes.	docosanol	122-131	sucrase isomaltase (alpha-glucosidase)	Mus musculus	238-255
30189596-6	2018	Taken altogether, in vitro and in vivo experiments suggest that selected natural compounds (curcumin, antroquinonol, HCD, docosanol, tetracosanol, rutin, and actinodaphnine) via molecular docking were confirmed as potential candidates of alpha-glucosidase and alpha-amylase inhibitors for treating diabetes.	1-Tetracosanol	133-145	sucrase isomaltase (alpha-glucosidase)	Mus musculus	238-255
30189596-6	2018	Taken altogether, in vitro and in vivo experiments suggest that selected natural compounds (curcumin, antroquinonol, HCD, docosanol, tetracosanol, rutin, and actinodaphnine) via molecular docking were confirmed as potential candidates of alpha-glucosidase and alpha-amylase inhibitors for treating diabetes.	Rutin	147-152	sucrase isomaltase (alpha-glucosidase)	Mus musculus	238-255
30189596-6	2018	Taken altogether, in vitro and in vivo experiments suggest that selected natural compounds (curcumin, antroquinonol, HCD, docosanol, tetracosanol, rutin, and actinodaphnine) via molecular docking were confirmed as potential candidates of alpha-glucosidase and alpha-amylase inhibitors for treating diabetes.	actinodaphine	158-172	sucrase isomaltase (alpha-glucosidase)	Mus musculus	238-255
29604377-0	2018	Pomegranate polyphenols and urolithin A inhibit alpha-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells.	Polyphenols	12-23	sucrase isomaltase (alpha-glucosidase)	Mus musculus	48-65
29621479-9	2018	In support of this possibility, we reported that acarbose (an alpha-glucosidase inhibitor) prevented sucrose, maltose and Polycose from eliciting CPIR.	Acarbose	49-57	sucrase isomaltase (alpha-glucosidase)	Mus musculus	62-79
29621479-9	2018	In support of this possibility, we reported that acarbose (an alpha-glucosidase inhibitor) prevented sucrose, maltose and Polycose from eliciting CPIR.	Sucrose	101-108	sucrase isomaltase (alpha-glucosidase)	Mus musculus	62-79
29621479-9	2018	In support of this possibility, we reported that acarbose (an alpha-glucosidase inhibitor) prevented sucrose, maltose and Polycose from eliciting CPIR.	Maltose	110-117	sucrase isomaltase (alpha-glucosidase)	Mus musculus	62-79
29621479-9	2018	In support of this possibility, we reported that acarbose (an alpha-glucosidase inhibitor) prevented sucrose, maltose and Polycose from eliciting CPIR.	Glucans	122-130	sucrase isomaltase (alpha-glucosidase)	Mus musculus	62-79
29604377-0	2018	Pomegranate polyphenols and urolithin A inhibit alpha-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	28-39	sucrase isomaltase (alpha-glucosidase)	Mus musculus	48-65
29604377-6	2018	RESULTS: Pomegranate juice, ellagic acid, punicalagin and urolithin A were able to inhibit lipase, alpha-glucosidase and dipeptidyl peptidase-4.	Ellagic Acid	28-40	sucrase isomaltase (alpha-glucosidase)	Mus musculus	99-116
29604377-6	2018	RESULTS: Pomegranate juice, ellagic acid, punicalagin and urolithin A were able to inhibit lipase, alpha-glucosidase and dipeptidyl peptidase-4.	punicalagin	42-53	sucrase isomaltase (alpha-glucosidase)	Mus musculus	99-116
29604377-6	2018	RESULTS: Pomegranate juice, ellagic acid, punicalagin and urolithin A were able to inhibit lipase, alpha-glucosidase and dipeptidyl peptidase-4.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	58-69	sucrase isomaltase (alpha-glucosidase)	Mus musculus	99-116
29844722-5	2018	Further, KS-TN11 was assessed for alpha-glucosidase inhibitory potential using the chromogenic method.	ks-tn11	9-16	sucrase isomaltase (alpha-glucosidase)	Mus musculus	34-51
29844722-10	2018	Moreover, L. mesenteroides KS-TN11 exhibited substantial alpha-glucosidase inhibitory activities by 41.33% at 50 mg/ml and 64% at 100 mg/ml, respectively.	ks-tn11	27-34	sucrase isomaltase (alpha-glucosidase)	Mus musculus	57-74
29634260-0	2018	Structural Modification of Natural Product Ganomycin I Leading to Discovery of a alpha-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo.	ganomycin I	43-54	sucrase isomaltase (alpha-glucosidase)	Mus musculus	81-98
29634260-2	2018	With ganomycin I as a leading compound, 14 meroterpene derivatives were synthesized and screened for their alpha-glucosidase and HMG-CoA reductase inhibitory activities.	ganomycin I	5-16	sucrase isomaltase (alpha-glucosidase)	Mus musculus	107-124
29634260-2	2018	With ganomycin I as a leading compound, 14 meroterpene derivatives were synthesized and screened for their alpha-glucosidase and HMG-CoA reductase inhibitory activities.	meroterpene	43-54	sucrase isomaltase (alpha-glucosidase)	Mus musculus	107-124
29634260-3	2018	As a result, a alpha-glucosidase and HMG-CoA reductase dual inhibitor (( R, E)-5-(4-( tert-butyl)phenyl)-3-(4,8-dimethylnona-3,7-dien-1-yl)furan-2(5 H)-one, 7d) with improved chemical stability and long-term safety was obtained.	( r, e)-5-(4-( tert-butyl)phenyl)-3-(4,8-dimethylnona-3,7-dien-1-yl)furan-2	71-146	sucrase isomaltase (alpha-glucosidase)	Mus musculus	15-32
29634260-3	2018	As a result, a alpha-glucosidase and HMG-CoA reductase dual inhibitor (( R, E)-5-(4-( tert-butyl)phenyl)-3-(4,8-dimethylnona-3,7-dien-1-yl)furan-2(5 H)-one, 7d) with improved chemical stability and long-term safety was obtained.	h)-one	149-155	sucrase isomaltase (alpha-glucosidase)	Mus musculus	15-32
29027933-11	2017	What"s more, the inhibitory effect of ME of PLT and its EA and n-BuOH fractions on alpha-glucosidase was significantly higher than that of acarbose.	methionylglutamic acid	38-40	sucrase isomaltase (alpha-glucosidase)	Mus musculus	83-100
28219252-4	2017	OBJECTIVE: This study investigated the inhibitory effects of 2,7""-phloroglucinol-6,6"-bieckol on activities of alpha-glucosidase and alpha-amylase as well as its alleviating effect on postprandial hyperglycaemia in streptozotocin-induced diabetic mice.	2,7''-phloroglucinol-6,6'-bieckol	61-94	sucrase isomaltase (alpha-glucosidase)	Mus musculus	112-129
28219252-9	2017	RESULTS: 2,7""-Phloroglucinol-6,6"-bieckol showed higher inhibitory activities than acarbose, a positive control against alpha-glucosidase and alpha-amylase.	2,7''-phloroglucinol-6,6'-bieckol	9-42	sucrase isomaltase (alpha-glucosidase)	Mus musculus	121-138
28219252-9	2017	RESULTS: 2,7""-Phloroglucinol-6,6"-bieckol showed higher inhibitory activities than acarbose, a positive control against alpha-glucosidase and alpha-amylase.	Acarbose	84-92	sucrase isomaltase (alpha-glucosidase)	Mus musculus	121-138
28219252-10	2017	The IC50 values of 2,7""-phloroglucinol-6,6"-bieckol against alpha-glucosidase and alpha-amylase were 23.35 and 6.94 muM, respectively, which was found more effective than observed with acarbose (alpha-glucosidase IC50 of 130.04 muM; alpha-amylase IC50 of 165.12 muM).	2,7''-phloroglucinol-6,6'-bieckol	19-52	sucrase isomaltase (alpha-glucosidase)	Mus musculus	61-78
28219252-10	2017	The IC50 values of 2,7""-phloroglucinol-6,6"-bieckol against alpha-glucosidase and alpha-amylase were 23.35 and 6.94 muM, respectively, which was found more effective than observed with acarbose (alpha-glucosidase IC50 of 130.04 muM; alpha-amylase IC50 of 165.12 muM).	2,7''-phloroglucinol-6,6'-bieckol	19-52	sucrase isomaltase (alpha-glucosidase)	Mus musculus	196-213
28219252-10	2017	The IC50 values of 2,7""-phloroglucinol-6,6"-bieckol against alpha-glucosidase and alpha-amylase were 23.35 and 6.94 muM, respectively, which was found more effective than observed with acarbose (alpha-glucosidase IC50 of 130.04 muM; alpha-amylase IC50 of 165.12 muM).	Acarbose	186-194	sucrase isomaltase (alpha-glucosidase)	Mus musculus	61-78
28219252-13	2017	DISCUSSION AND CONCLUSION: 2,7""-Phloroglucinol-6,6"-bieckol might be used as an inhibitor of alpha-glucosidase and alpha-amylase as well as to delay absorption of dietary carbohydrates.	2,7''-phloroglucinol-6,6'-bieckol	27-60	sucrase isomaltase (alpha-glucosidase)	Mus musculus	94-111
28349245-2	2017	alpha-glucosidase inhibitors (alpha-GIs) delay carbohydrate absorption and may change the gut environment.	Carbohydrates	47-59	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
29027933-14	2017	Further studies on PLT showed that the substances in PLT ME could reduce the level of mouse postprandial blood glucose through inhibiting the activity of alpha-glucosidase.	Glucose	111-118	sucrase isomaltase (alpha-glucosidase)	Mus musculus	154-171
29361825-0	2018	Erythritol Attenuates Postprandial Blood Glucose by Inhibiting alpha-Glucosidase.	Erythritol	0-10	sucrase isomaltase (alpha-glucosidase)	Mus musculus	63-80
29361825-5	2018	We also found that erythritol most likely exerts its anti-postprandial hyperglycemic activities by inhibiting alpha-glucosidase in a competitive manner.	Erythritol	19-29	sucrase isomaltase (alpha-glucosidase)	Mus musculus	110-127
29361825-7	2018	In the latter experiments, it was possible to successfully dock erythritol into the catalytic pocket of alpha-glucosidase, with the resultant interaction likely driven by electrostatic interactions involving Asp215, Asp69, and Arg446 residues.	Erythritol	64-74	sucrase isomaltase (alpha-glucosidase)	Mus musculus	104-121
29400565-9	2018	The AgNPs has reduced the activity of alpha-amylase, alpha-glucosidase and dipeptidyl peptidase IV in vitro antidiabetic activity.	agnps	4-9	sucrase isomaltase (alpha-glucosidase)	Mus musculus	53-70
28756277-0	2017	New carbazole linked 1,2,3-triazoles as highly potent non-sugar alpha-glucosidase inhibitors.	carbazole	4-13	sucrase isomaltase (alpha-glucosidase)	Mus musculus	64-81
28756277-0	2017	New carbazole linked 1,2,3-triazoles as highly potent non-sugar alpha-glucosidase inhibitors.	1,2,3-triazoles	21-36	sucrase isomaltase (alpha-glucosidase)	Mus musculus	64-81
28756277-2	2017	Synthesized carbazole triazoles including 7, 9, 10, 19, 20, and 23-26 (IC50=0.8+-0.01-100.8+-3.6muM), exhibited several folds more potent alpha-glucosidase inhibitory in vitro activity as compared to standard drug, acarbose.	carbazole triazoles	12-31	sucrase isomaltase (alpha-glucosidase)	Mus musculus	138-155
28756277-2	2017	Synthesized carbazole triazoles including 7, 9, 10, 19, 20, and 23-26 (IC50=0.8+-0.01-100.8+-3.6muM), exhibited several folds more potent alpha-glucosidase inhibitory in vitro activity as compared to standard drug, acarbose.	Acarbose	215-223	sucrase isomaltase (alpha-glucosidase)	Mus musculus	138-155
29027933-11	2017	What"s more, the inhibitory effect of ME of PLT and its EA and n-BuOH fractions on alpha-glucosidase was significantly higher than that of acarbose.	1-Butanol	65-69	sucrase isomaltase (alpha-glucosidase)	Mus musculus	83-100
28346872-0	2017	5-Bromo-2-aryl benzimidazole derivatives as non-cytotoxic potential dual inhibitors of alpha-glucosidase and urease enzymes.	5-bromo-2-aryl benzimidazole	0-28	sucrase isomaltase (alpha-glucosidase)	Mus musculus	87-104
28346872-5	2017	Previously benzimidazole 1-25 were also showed alpha-glucosidase inhibitory potential.	benzimidazole 1-25	11-29	sucrase isomaltase (alpha-glucosidase)	Mus musculus	47-64
26912275-0	2016	Ultrasonic synthesis of tyramine derivatives as novel inhibitors of alpha-glucosidase in vitro.	Tyramine	24-32	sucrase isomaltase (alpha-glucosidase)	Mus musculus	68-85
27856936-1	2017	Pompe disease is a rare neuromuscular disorder caused by an acid alpha-glucosidase (GAA) deficiency resulting in glycogen accumulation in muscle, leading to myopathy and respiratory weakness.	Glycogen	113-121	sucrase isomaltase (alpha-glucosidase)	Mus musculus	65-82
27383805-2	2017	We previously reported that lignosulfonic acid suppresses the rise in blood glucose levels through the inhibition of alpha-glucosidase activity and intestinal glucose absorption.	LIGNOSULFONIC ACID	28-46	sucrase isomaltase (alpha-glucosidase)	Mus musculus	117-134
27383805-2	2017	We previously reported that lignosulfonic acid suppresses the rise in blood glucose levels through the inhibition of alpha-glucosidase activity and intestinal glucose absorption.	Glucose	76-83	sucrase isomaltase (alpha-glucosidase)	Mus musculus	117-134
27935584-4	2017	Here, we show that the ketone body beta-hydroxybutyrate (betaHB), an endogenous inhibitor of histone deacetylases (HDACs) induces intestinal cell differentiation as noted by the increased expression of differentiation markers (Mucin2 (MUC2), lysozyme, IAP, sucrase-isomaltase, KRT20, villin, Caudal-related homeobox transcription factor 2 (CDX2) and p21Waf1).	Ketones	23-29	sucrase isomaltase (alpha-glucosidase)	Mus musculus	257-275
27935584-4	2017	Here, we show that the ketone body beta-hydroxybutyrate (betaHB), an endogenous inhibitor of histone deacetylases (HDACs) induces intestinal cell differentiation as noted by the increased expression of differentiation markers (Mucin2 (MUC2), lysozyme, IAP, sucrase-isomaltase, KRT20, villin, Caudal-related homeobox transcription factor 2 (CDX2) and p21Waf1).	3-Hydroxybutyric Acid	35-55	sucrase isomaltase (alpha-glucosidase)	Mus musculus	257-275
27935584-4	2017	Here, we show that the ketone body beta-hydroxybutyrate (betaHB), an endogenous inhibitor of histone deacetylases (HDACs) induces intestinal cell differentiation as noted by the increased expression of differentiation markers (Mucin2 (MUC2), lysozyme, IAP, sucrase-isomaltase, KRT20, villin, Caudal-related homeobox transcription factor 2 (CDX2) and p21Waf1).	3-Hydroxybutyric Acid	57-63	sucrase isomaltase (alpha-glucosidase)	Mus musculus	257-275
28132506-1	2017	Inhibition of alpha-glucosidase and alpha-amylase decreases postprandial blood glucose levels and delays glucose absorption, making it a treatment strategy for type 2 diabetes.	Glucose	79-86	sucrase isomaltase (alpha-glucosidase)	Mus musculus	14-31
28132506-1	2017	Inhibition of alpha-glucosidase and alpha-amylase decreases postprandial blood glucose levels and delays glucose absorption, making it a treatment strategy for type 2 diabetes.	Glucose	105-112	sucrase isomaltase (alpha-glucosidase)	Mus musculus	14-31
28132506-3	2017	3"-Geranylchalconaringenin (2) competitively and irreversibly inhibited alpha-glucosidase (IC50 = 1.08 muM) with activity 50-fold higher than that of acarbose (IC50 = 51.30 muM) and showed moderate inhibitory activity against alpha-amylase (IC50 = 20.46 muM).	3'-geranylchalconaringenin	0-26	sucrase isomaltase (alpha-glucosidase)	Mus musculus	72-89
27839787-6	2017	Ganomycin I (4), the most potent inhibitor against both alpha-glucosidase and HMG-CoA reductase, was synthesized and evaluated for its in vivo bioactivity.	ganomycin I	0-11	sucrase isomaltase (alpha-glucosidase)	Mus musculus	56-73
28168055-0	2017	In Vitro and In Vivo Effects of Norathyriol and Mangiferin on alpha-Glucosidase.	norathyriol	32-43	sucrase isomaltase (alpha-glucosidase)	Mus musculus	62-79
28168055-5	2017	The results showed that norathyriol inhibited alpha-glucosidase in a noncompetitive manner with an IC50 value of 3.12 muM, which is more potent than mangiferin (IC50 = 358.54 muM) and positive drug acarbose (IC50 = 479.2 muM) in the zymological experiment.	norathyriol	24-35	sucrase isomaltase (alpha-glucosidase)	Mus musculus	46-63
28168055-5	2017	The results showed that norathyriol inhibited alpha-glucosidase in a noncompetitive manner with an IC50 value of 3.12 muM, which is more potent than mangiferin (IC50 = 358.54 muM) and positive drug acarbose (IC50 = 479.2 muM) in the zymological experiment.	Acarbose	198-206	sucrase isomaltase (alpha-glucosidase)	Mus musculus	46-63
28168055-8	2017	Therefore, the antidiabetic effects of norathyriol and mangiferin might be associated with alpha-glucosidase, and norathyriol was more potent than mangiferin.	norathyriol	39-50	sucrase isomaltase (alpha-glucosidase)	Mus musculus	91-108
28168055-8	2017	Therefore, the antidiabetic effects of norathyriol and mangiferin might be associated with alpha-glucosidase, and norathyriol was more potent than mangiferin.	mangiferin	55-65	sucrase isomaltase (alpha-glucosidase)	Mus musculus	91-108
26830109-1	2016	UNLABELLED:  : Starch requires six enzymes for digestion to free glucose: two amylases (salivary and pancreatic) and four mucosal maltase activities; sucrase-isomaltase and maltase-glucoamylase.	Starch	15-21	sucrase isomaltase (alpha-glucosidase)	Mus musculus	150-168
26912275-12	2016	The current study describes the synthesis alpha-glucosidase inhibitory activity of derivatives, based on a natural product tyramine template.	Tyramine	123-131	sucrase isomaltase (alpha-glucosidase)	Mus musculus	42-59
27312235-10	2016	The alpha-glucosidase inhibitor, acarbose, at a concentration previously tested (1000 ppm), significantly increased median longevity in males and 90th percentile lifespan in both sexes, even when treatment was started at 16 months.	Acarbose	33-41	sucrase isomaltase (alpha-glucosidase)	Mus musculus	4-21
27399232-0	2016	Alkaloids from the Fungus Penicillium spathulatum as alpha-Glucosidase Inhibitors.	Alkaloids	0-9	sucrase isomaltase (alpha-glucosidase)	Mus musculus	53-70
27399232-5	2016	The alpha-glucosidase inhibitory properties of 1 were confirmed in vivo with an oral sucrose tolerance test in normal and hyperglycemic mice (p < 0.05).	Sucrose	85-92	sucrase isomaltase (alpha-glucosidase)	Mus musculus	4-21
27036710-10	2016	The in vivo study using SD rat and db/db mice models also showed that ZME reduces postprandial increases of blood glucose level after an oral administration of sucrose by possibly acting as an intestinal alpha-glucosidase inhibitor (ZME 0.1 g/kg 55.61 +- 13.24 mg/dL) CONCLUSION: The results indicate that Zingiber mioga extracts exhibited significant in vitro alpha-glucosidase inhibition and antioxidant activity.	6-(3-Methyl-1h-Pyrrol-1-Yl)-9h-Purine	70-73	sucrase isomaltase (alpha-glucosidase)	Mus musculus	204-221
27133429-0	2016	Improvement of blood glucose levels and obesity in mice given aronia juice by inhibition of dipeptidyl peptidase IV and alpha-glucosidase.	aronia juice	62-74	sucrase isomaltase (alpha-glucosidase)	Mus musculus	120-137
27133429-8	2016	Furthermore, alpha-glucosidase activity was inhibited in the upper region of the small intestine from aronia-juice-administered KK-Ay mice but not in the lower region.	aronia-juice	102-114	sucrase isomaltase (alpha-glucosidase)	Mus musculus	13-30
27029351-1	2016	BACKGROUND: Ficus lutea crude acetone leaf extracts were previously shown to stimulate glucose uptake and insulin secretion of established cells and, inhibit alpha-amylase and alpha-glucosidase activities.	Acetone	30-37	sucrase isomaltase (alpha-glucosidase)	Mus musculus	176-193
27029351-3	2016	RESULTS: Among these fractions, the ethyl acetate fraction had the highest total polyphenol content (100.5 +- 1.6 mg GAE/g dried extract) and alpha-glucosidase inhibitory activity (126.8 +- 30.6 mug/ml).	ethyl acetate	36-49	sucrase isomaltase (alpha-glucosidase)	Mus musculus	142-159
27036710-10	2016	The in vivo study using SD rat and db/db mice models also showed that ZME reduces postprandial increases of blood glucose level after an oral administration of sucrose by possibly acting as an intestinal alpha-glucosidase inhibitor (ZME 0.1 g/kg 55.61 +- 13.24 mg/dL) CONCLUSION: The results indicate that Zingiber mioga extracts exhibited significant in vitro alpha-glucosidase inhibition and antioxidant activity.	6-(3-Methyl-1h-Pyrrol-1-Yl)-9h-Purine	70-73	sucrase isomaltase (alpha-glucosidase)	Mus musculus	361-378
27036710-10	2016	The in vivo study using SD rat and db/db mice models also showed that ZME reduces postprandial increases of blood glucose level after an oral administration of sucrose by possibly acting as an intestinal alpha-glucosidase inhibitor (ZME 0.1 g/kg 55.61 +- 13.24 mg/dL) CONCLUSION: The results indicate that Zingiber mioga extracts exhibited significant in vitro alpha-glucosidase inhibition and antioxidant activity.	6-(3-Methyl-1h-Pyrrol-1-Yl)-9h-Purine	233-236	sucrase isomaltase (alpha-glucosidase)	Mus musculus	204-221
26381063-1	2015	We describe here the synthesis of dihydropyrimidines derivatives 3a-p, and evaluation of their alpha-glucosidase enzyme inhibition activities.	dihydropyrimidines	34-52	sucrase isomaltase (alpha-glucosidase)	Mus musculus	95-112
26980998-8	2016	In addition, the crude methanol extract and EtOAc strongly inhibited alpha-glucosidase activity and suppressed the secretion of pro-inflammatory mediator and nitrite oxide from LPS-stimulated RAW 264.7 cells.	Methanol	23-31	sucrase isomaltase (alpha-glucosidase)	Mus musculus	69-86
26980998-8	2016	In addition, the crude methanol extract and EtOAc strongly inhibited alpha-glucosidase activity and suppressed the secretion of pro-inflammatory mediator and nitrite oxide from LPS-stimulated RAW 264.7 cells.	ethyl acetate	44-49	sucrase isomaltase (alpha-glucosidase)	Mus musculus	69-86
26739611-7	2016	In vivo diabetic mice model studies with eugenol showed reduction in blood glucose levels by 38% likely due to inhibition of alpha-glucosidase while insulin and glycated hemoglobin levels remain unchanged.	Eugenol	41-48	sucrase isomaltase (alpha-glucosidase)	Mus musculus	125-142
26739611-10	2016	Thus, we propose eugenol has dual mode of action in combating diabetes; it lowers blood glucose by inhibiting alpha-glucosidase and prevents AGE formation by binding to epsilon-amine group on lysine, protecting it from glycation, offering potential use in diabetic management.	Eugenol	17-24	sucrase isomaltase (alpha-glucosidase)	Mus musculus	110-127
26690098-1	2015	1-Deoxynojirimycin (DNJ) is widely used for the treatment of diabetes mellitus as an inhibitor of intestinal alpha-glucosidase.	1-Deoxynojirimycin	0-18	sucrase isomaltase (alpha-glucosidase)	Mus musculus	109-126
26690098-1	2015	1-Deoxynojirimycin (DNJ) is widely used for the treatment of diabetes mellitus as an inhibitor of intestinal alpha-glucosidase.	1-Deoxynojirimycin	20-23	sucrase isomaltase (alpha-glucosidase)	Mus musculus	109-126
26129821-6	2015	Analyses of small and large intestines of mice treated with SAHA revealed a repression of crypt cell proliferation and a higher expression of sucrase-isomaltase in both segments compared to control mice.	Vorinostat	60-64	sucrase isomaltase (alpha-glucosidase)	Mus musculus	142-160
26400487-2	2015	Therefore, we investigated the effect of 1-deoxynojirimycin (DNJ), an alkaloid acting as an inhibitor of alpha-glucosidase, on age-related behavioral and biochemical changes.	1-DEOXYNOJIRIMYCIN	41-59	sucrase isomaltase (alpha-glucosidase)	Mus musculus	105-122
26400487-2	2015	Therefore, we investigated the effect of 1-deoxynojirimycin (DNJ), an alkaloid acting as an inhibitor of alpha-glucosidase, on age-related behavioral and biochemical changes.	1-DEOXYNOJIRIMYCIN	61-64	sucrase isomaltase (alpha-glucosidase)	Mus musculus	105-122
25698601-2	2015	In the present study, we investigated the effect of acarbose, an inhibitor of alpha-glucosidase, on age-related behavioral and biochemical changes.	Acarbose	52-60	sucrase isomaltase (alpha-glucosidase)	Mus musculus	78-95
26022844-0	2015	Discovery of xanthine oxidase inhibitors and/or alpha-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin.	Flavonoids	121-130	sucrase isomaltase (alpha-glucosidase)	Mus musculus	48-65
25820466-0	2015	Pu-erh tea polysaccharides decrease blood sugar by inhibition of alpha-glucosidase activity in vitro and in mice.	pu-erh tea polysaccharides	0-26	sucrase isomaltase (alpha-glucosidase)	Mus musculus	65-82
25820466-0	2015	Pu-erh tea polysaccharides decrease blood sugar by inhibition of alpha-glucosidase activity in vitro and in mice.	Sugars	42-47	sucrase isomaltase (alpha-glucosidase)	Mus musculus	65-82
25820466-2	2015	Acarbose, a microbial carbohydrate and an alpha-glucosidase inhibitor, is currently a useful agent for attenuating type 2 diabetes.	Acarbose	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	42-59
25820466-7	2015	In this report we describe a group of carbohydrates found in pu-erh tea polysaccharide (PTPS) that can inhibit alpha-glucosidase but have less of an inhibitory effect on alpha-amylase.	Carbohydrates	38-51	sucrase isomaltase (alpha-glucosidase)	Mus musculus	111-128
25820466-7	2015	In this report we describe a group of carbohydrates found in pu-erh tea polysaccharide (PTPS) that can inhibit alpha-glucosidase but have less of an inhibitory effect on alpha-amylase.	pu-erh tea polysaccharide	61-86	sucrase isomaltase (alpha-glucosidase)	Mus musculus	111-128
25820466-7	2015	In this report we describe a group of carbohydrates found in pu-erh tea polysaccharide (PTPS) that can inhibit alpha-glucosidase but have less of an inhibitory effect on alpha-amylase.	ptps	88-92	sucrase isomaltase (alpha-glucosidase)	Mus musculus	111-128
25680946-1	2015	This study was designed to investigate whether phlorofucofuroeckol A inhibited alpha-glucosidase and alpha-amylase activities and alleviated postprandial hyperglycemia in diabetic mice.	phlorofucofuroeckol A	47-68	sucrase isomaltase (alpha-glucosidase)	Mus musculus	79-96
25680946-2	2015	Phlorofucofuroeckol A that was isolated from Ecklonia cava (brown algae) demonstrated prominent inhibitory effects against alpha-glucosidase and alpha-amylase activities.	phlorofucofuroeckol A	0-21	sucrase isomaltase (alpha-glucosidase)	Mus musculus	123-140
25680946-3	2015	The IC50 values of phlorofucofuroeckol A against alpha-glucosidase and alpha-amylase were 19.52 and 6.34muM, respectively.	phlorofucofuroeckol A	19-40	sucrase isomaltase (alpha-glucosidase)	Mus musculus	49-66
25680946-7	2015	These results suggested that phlorofucofuroeckol A is a potent alpha-glucosidase inhibitor and can alleviate the postprandial hyperglycemia that is caused by starch.	phlorofucofuroeckol A	29-50	sucrase isomaltase (alpha-glucosidase)	Mus musculus	63-80
25473361-10	2014	In addition, inhibition of alpha-glucosidase activity of hot water extract was determined using p-nitrophenyl-alpha-d-glucopyranoside (pNPG) as a substrate.	4-nitrophenyl alpha-glucoside	96-133	sucrase isomaltase (alpha-glucosidase)	Mus musculus	27-44
25665941-7	2015	However, in vitro alpha-amylase and alpha-glucosidase inhibition assay showed low inhibition under treatment of vindogentianine.	vindogentianine	112-127	sucrase isomaltase (alpha-glucosidase)	Mus musculus	36-53
25833077-1	2015	Miglitol is an absorbable alpha-glucosidase inhibitor that is used to control post-prandial hyperglycemia.	miglitol	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	26-43
25473361-10	2014	In addition, inhibition of alpha-glucosidase activity of hot water extract was determined using p-nitrophenyl-alpha-d-glucopyranoside (pNPG) as a substrate.	4-nitrophenyl alpha-glucoside	135-139	sucrase isomaltase (alpha-glucosidase)	Mus musculus	27-44
25473361-14	2014	In addition, hot water extract of A. arguta stem exhibited appreciable inhibitory activity against alpha-glucosidase enzyme with IC50 of 1.71 mg/ml.	Water	17-22	sucrase isomaltase (alpha-glucosidase)	Mus musculus	99-116
23838818-1	2013	OBJECTIVES: Six enzyme activities are needed to digest starch to absorbable free glucose; 2 luminal alpha-amylases (AMY) and 4 mucosal maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) subunit activities are involved in the digestion.	Starch	55-61	sucrase isomaltase (alpha-glucosidase)	Mus musculus	167-185
25231351-0	2014	Suppression of mTORC1 activation in acid-alpha-glucosidase-deficient cells and mice is ameliorated by leucine supplementation.	Leucine	102-109	sucrase isomaltase (alpha-glucosidase)	Mus musculus	41-58
25145393-0	2014	Octaphlorethol A: a potent alpha-glucosidase inhibitor isolated from Ishige foliacea shows an anti-hyperglycemic effect in mice with streptozotocin-induced diabetes.	octaphlorethol A	0-16	sucrase isomaltase (alpha-glucosidase)	Mus musculus	27-44
25145393-0	2014	Octaphlorethol A: a potent alpha-glucosidase inhibitor isolated from Ishige foliacea shows an anti-hyperglycemic effect in mice with streptozotocin-induced diabetes.	Streptozocin	133-147	sucrase isomaltase (alpha-glucosidase)	Mus musculus	27-44
25145393-2	2014	The current study examined the inhibitory effects of octaphlorethol A (OPA) isolated from Ishige foliacea, a brown alga, on alpha-glucosidase, and analyzed the inhibitor"s binding modes using the crystal structure of alpha-glucosidase.	octaphlorethol A	53-69	sucrase isomaltase (alpha-glucosidase)	Mus musculus	124-141
25145393-2	2014	The current study examined the inhibitory effects of octaphlorethol A (OPA) isolated from Ishige foliacea, a brown alga, on alpha-glucosidase, and analyzed the inhibitor"s binding modes using the crystal structure of alpha-glucosidase.	octaphlorethol A	53-69	sucrase isomaltase (alpha-glucosidase)	Mus musculus	217-234
24892833-19	2014	Salvinine (4) turned out to be a mixed alpha-glucosidase inhibitor, while 3 was inactive.	19-hydroxy-12,14-dioxolabda-15,17-diene	0-9	sucrase isomaltase (alpha-glucosidase)	Mus musculus	39-56
24105419-0	2014	Platycodi radix saponin inhibits alpha-glucosidase in vitro and modulates hepatic glucose-regulating enzyme activities in C57BL/KsJ-db/db mice.	Saponins	16-23	sucrase isomaltase (alpha-glucosidase)	Mus musculus	33-50
24992766-11	2014	The extracts showed an inhibitory effect on alpha-glucosidase activity at the concentrations of 15.6-125 microg/mL with a half maximal (50%) inhibitory concentration (IC50) of (32.8 +/- 5.7) microg/mL, compared with the IC50 of acarbose at (1.8 +/- 0.4) microg/mL.	Acarbose	228-236	sucrase isomaltase (alpha-glucosidase)	Mus musculus	44-61
24823880-2	2014	In the present study we extended our recent findings to evaluate whether alpha-glucosidase inhibitor arginyl-fructose (AF) lowers blood glucose level in diabetic db/db mice, a genetic model for type 2 diabetes.	fructosyl arginine	101-117	sucrase isomaltase (alpha-glucosidase)	Mus musculus	73-90
24823880-2	2014	In the present study we extended our recent findings to evaluate whether alpha-glucosidase inhibitor arginyl-fructose (AF) lowers blood glucose level in diabetic db/db mice, a genetic model for type 2 diabetes.	Glucose	136-143	sucrase isomaltase (alpha-glucosidase)	Mus musculus	73-90
24587809-4	2014	In vitro assay revealed that the BBEE strongly inhibited both alpha -glucosidase and sucrase activities whose IC50 values were 8.0 and 0.24  mu g/mL, respectively.	bbee	33-37	sucrase isomaltase (alpha-glucosidase)	Mus musculus	62-80
24587809-5	2014	The kinetic analysis showed that the BBEE as a kind of alpha -glucosidase inhibitor characterized a competitive inhibition activity.	bbee	37-41	sucrase isomaltase (alpha-glucosidase)	Mus musculus	55-73
24587809-8	2014	Therefore, the BBEE could effectively inhibit the postprandial hyperglycemia as a novel alpha -glucosidase activity inhibitor for the diabetic therapy.	bbee	15-19	sucrase isomaltase (alpha-glucosidase)	Mus musculus	88-106
24813878-4	2014	These compounds were more potent than acarbose (positive control) against alpha-glucosidase.	Acarbose	38-46	sucrase isomaltase (alpha-glucosidase)	Mus musculus	74-91
23526625-8	2013	Both ANC- and PAC-enriched fractions inhibited starch-degrading enzyme alpha-glucosidase and dipeptidyl peptidase-IV activity.	Starch	47-53	sucrase isomaltase (alpha-glucosidase)	Mus musculus	71-88
23887940-4	2013	In conventionally raised mice, cortisone acetate (CA) precociously accelerated SI gene expression up to 3 weeks and fut2 to 4 weeks of age.	Cortisone	31-48	sucrase isomaltase (alpha-glucosidase)	Mus musculus	79-81
23809634-0	2013	Thielavins A, J and K: alpha-Glucosidase inhibitors from MEXU 27095, an endophytic fungus from Hintonia latiflora.	thielavin A	0-12	sucrase isomaltase (alpha-glucosidase)	Mus musculus	23-40
23809634-4	2013	Thielavin J inhibited the activity of alpha-glucosidase from Bacillus stearothermophilus (alphaGHBs) with an IC50 of 30.5muM, being less active than acarbose (IC50=0.	thielavin J	0-11	sucrase isomaltase (alpha-glucosidase)	Mus musculus	38-55
23809634-4	2013	Thielavin J inhibited the activity of alpha-glucosidase from Bacillus stearothermophilus (alphaGHBs) with an IC50 of 30.5muM, being less active than acarbose (IC50=0.	alphaghbs	90-99	sucrase isomaltase (alpha-glucosidase)	Mus musculus	38-55
23809634-7	2013	The alpha-glucosidase inhibitory properties of thielavin K (3) were corroborated in vivo since it induced a noted antihyperglycemic action during an oral sucrose tolerance test (3.1, 10.0 and 31.6mg/kg) in normal and nicotinamide-streptozotocin diabetic mice.	thielavin k (3)	47-62	sucrase isomaltase (alpha-glucosidase)	Mus musculus	4-21
23669248-1	2013	This study was designed to investigate whether daidzein inhibits alpha-glucosidase and alpha-amylase activities and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice.	daidzein	47-55	sucrase isomaltase (alpha-glucosidase)	Mus musculus	65-82
23669248-2	2013	Daidzein showed prominent inhibitory effects against alpha-glucosidase and alpha-amylase.	daidzein	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	53-70
23669248-3	2013	The IC50 values of daidzein against alpha-glucosidase and alpha-amylase were 0.048 and 0.301 mmol, respectively, which showed that daidzein was more effective than acarbose.	daidzein	19-27	sucrase isomaltase (alpha-glucosidase)	Mus musculus	36-53
23669248-3	2013	The IC50 values of daidzein against alpha-glucosidase and alpha-amylase were 0.048 and 0.301 mmol, respectively, which showed that daidzein was more effective than acarbose.	daidzein	131-139	sucrase isomaltase (alpha-glucosidase)	Mus musculus	36-53
23669248-3	2013	The IC50 values of daidzein against alpha-glucosidase and alpha-amylase were 0.048 and 0.301 mmol, respectively, which showed that daidzein was more effective than acarbose.	Acarbose	164-172	sucrase isomaltase (alpha-glucosidase)	Mus musculus	36-53
23669248-6	2013	These results indicated that daidzein may be a potent alpha-glucosidase inhibitor and suppress the postprandial hyperglycemia caused by starch.	daidzein	29-37	sucrase isomaltase (alpha-glucosidase)	Mus musculus	54-71
24471127-3	2013	Optimum ripened BKE was used in this study as it showed the strongest inhibitory activities on alpha-glucosidase and alpha-amylase by fermentation time among the BKEs in our previous study.	7-(4-Methoxyphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ol	16-19	sucrase isomaltase (alpha-glucosidase)	Mus musculus	95-112
24471127-3	2013	Optimum ripened BKE was used in this study as it showed the strongest inhibitory activities on alpha-glucosidase and alpha-amylase by fermentation time among the BKEs in our previous study.	bkes	162-166	sucrase isomaltase (alpha-glucosidase)	Mus musculus	95-112
24471127-5	2013	The BKE extract showed higher inhibitory activities than Baechu kimchi extract against alpha-glucosidase and alpha-amylase.	7-(4-Methoxyphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ol	4-7	sucrase isomaltase (alpha-glucosidase)	Mus musculus	87-104
24471127-6	2013	The IC50 values of the BKE extract against alpha-glucosidase and alpha-amylase were 0.58 and 0.35 mg/mL, respectively; BKE exhibited a lower alpha-glucosidase inhibitory activity but a higher alpha-amylase inhibitory activity than those of acarbose.	7-(4-Methoxyphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ol	23-26	sucrase isomaltase (alpha-glucosidase)	Mus musculus	43-60
24471127-6	2013	The IC50 values of the BKE extract against alpha-glucosidase and alpha-amylase were 0.58 and 0.35 mg/mL, respectively; BKE exhibited a lower alpha-glucosidase inhibitory activity but a higher alpha-amylase inhibitory activity than those of acarbose.	7-(4-Methoxyphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ol	119-122	sucrase isomaltase (alpha-glucosidase)	Mus musculus	141-158
23194643-0	2013	The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice.	Bile Acids and Salts	49-58	sucrase isomaltase (alpha-glucosidase)	Mus musculus	4-21
23754387-5	2013	The altered glycogen is associated with fluctuations in lysosomal and neutral alpha-glucosidase activities.	Glycogen	12-20	sucrase isomaltase (alpha-glucosidase)	Mus musculus	78-95
21906578-2	2012	This is the case for Pompe disease caused by acid alpha-glucosidase (GAA) deficiency, leading to excess glycogen storage throughout the body, mainly the liver and striated muscle.	Glycogen	104-112	sucrase isomaltase (alpha-glucosidase)	Mus musculus	50-67
23995917-1	2013	Miglitol is an alpha-glucosidase inhibitor that improves post-prandial hyperglycemia, and it is the only drug in its class that enters the bloodstream.	miglitol	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	15-32
22779928-3	2012	Mangostenone F was shown to be inactive against tyrosinase (IC50 > 200 muM) but was a potent alpha-glucosidase inhibitor in vitro (IC50 = 21.0 muM).	mangostenone F	0-14	sucrase isomaltase (alpha-glucosidase)	Mus musculus	96-113
21699755-0	2011	Effects of novel chalcone derivatives on alpha-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro.	Chalcone	17-25	sucrase isomaltase (alpha-glucosidase)	Mus musculus	41-58
22239964-1	2012	Glycogen storage in the alpha-glucosidase knockout((6neo/6neo)) mouse recapitulates the biochemical defect that occurs in the human condition; as such, this mouse serves as a model for the inherited metabolic deficiency of lysosomal acid alpha-glucosidase known as Pompe disease.	Glycogen	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	24-41
22239964-1	2012	Glycogen storage in the alpha-glucosidase knockout((6neo/6neo)) mouse recapitulates the biochemical defect that occurs in the human condition; as such, this mouse serves as a model for the inherited metabolic deficiency of lysosomal acid alpha-glucosidase known as Pompe disease.	Glycogen	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	238-255
21928165-6	2012	Lonchocarpene and DPS inhibited alpha-glucosidase in vitro, with pIC(50) values of 5.68 +- 0.12 and 5.73 +- 0.08, respectively.	lonchocarpene	0-13	sucrase isomaltase (alpha-glucosidase)	Mus musculus	32-49
21928165-6	2012	Lonchocarpene and DPS inhibited alpha-glucosidase in vitro, with pIC(50) values of 5.68 +- 0.12 and 5.73 +- 0.08, respectively.	3,5-dimethoxy-4'-O-prenyl-trans-stilbene	18-21	sucrase isomaltase (alpha-glucosidase)	Mus musculus	32-49
22103717-5	2012	MATERIALS AND METHODS: Inhibitory activities of KPP against alpha-amylase and alpha-glucosidase in vitro, and effects on oral carbohydrate tolerance test in vivo were investigated.	kpp	48-51	sucrase isomaltase (alpha-glucosidase)	Mus musculus	78-95
22338549-1	2012	OBJECTIVE: The present study investigated the antioxidant, antiglycation and inhibitory potential of flavonoid fraction of Saraca ashoka flowers (SAF) against alpha-glucosidase and alpha-amylase (the enzymes linked to type 2 diabetes) and LDL oxidation.	Flavonoids	101-110	sucrase isomaltase (alpha-glucosidase)	Mus musculus	159-176
22338549-6	2012	Significant inhibitory potential against alpha-glucosidase and alpha-amylase enzymes revealed the therapeutic potential of SAF as an antihyperglycemic agent.	Safflower Oil	123-126	sucrase isomaltase (alpha-glucosidase)	Mus musculus	41-58
22133267-2	2011	Quercetin and isoquercetin are both powerful alpha-glucosidase inhibitors.	Quercetin	0-9	sucrase isomaltase (alpha-glucosidase)	Mus musculus	45-62
22133267-2	2011	Quercetin and isoquercetin are both powerful alpha-glucosidase inhibitors.	isoquercitrin	14-26	sucrase isomaltase (alpha-glucosidase)	Mus musculus	45-62
22133267-3	2011	Although the IC50 of isoquercetin as alpha-glucosidase inhibitor was much higher than that of quercetin, the bioavailability of isoquercetin was higher than that of quercetin.	isoquercitrin	21-33	sucrase isomaltase (alpha-glucosidase)	Mus musculus	37-54
22133267-3	2011	Although the IC50 of isoquercetin as alpha-glucosidase inhibitor was much higher than that of quercetin, the bioavailability of isoquercetin was higher than that of quercetin.	Quercetin	24-33	sucrase isomaltase (alpha-glucosidase)	Mus musculus	37-54
21699755-2	2011	To evaluate the possibility of Chana series as therapeutic agents of type 2 diabetes, the inhibitory effects of Chana series on the activities of alpha-glucosidase and DPP-4 were investigated using in vitro enzyme assays, and their effects on adipocyte differentiation were investigated in C3H10T1/2 cells.	chana	112-117	sucrase isomaltase (alpha-glucosidase)	Mus musculus	146-163
21699755-7	2011	Therefore, Chana 1 showed inhibitory effects on alpha-glucosidase and DPP-4 as well as a stimulatory effect on adipocyte differentiation, suggesting that Chana 1 may be a potential beneficial agent for the treatment of type 2 diabetes.	chana 1	11-18	sucrase isomaltase (alpha-glucosidase)	Mus musculus	48-65
20600532-0	2010	Dieckol isolated from Ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice.	dieckol	0-7	sucrase isomaltase (alpha-glucosidase)	Mus musculus	45-62
20879744-0	2011	(Z)-3-butylidenephthalide from Ligusticum porteri , an alpha-glucosidase inhibitor.	butylidenephthalide	0-25	sucrase isomaltase (alpha-glucosidase)	Mus musculus	55-72
20739059-4	2010	Macrophages incorporate ferucarbotran in lysosomal vesicles containing alpha-glucosidase, which is capable of degrading the carboxydextran shell of the ferucarbotran particles.	ferumoxides	24-37	sucrase isomaltase (alpha-glucosidase)	Mus musculus	71-88
20739059-4	2010	Macrophages incorporate ferucarbotran in lysosomal vesicles containing alpha-glucosidase, which is capable of degrading the carboxydextran shell of the ferucarbotran particles.	carboxydextran	124-138	sucrase isomaltase (alpha-glucosidase)	Mus musculus	71-88
20739059-4	2010	Macrophages incorporate ferucarbotran in lysosomal vesicles containing alpha-glucosidase, which is capable of degrading the carboxydextran shell of the ferucarbotran particles.	ferumoxides	152-165	sucrase isomaltase (alpha-glucosidase)	Mus musculus	71-88
20600532-1	2010	This study was designed to investigate whether dieckol may inhibit alpha-glucosidase and alpha-amylase activities, and alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice.	dieckol	47-54	sucrase isomaltase (alpha-glucosidase)	Mus musculus	67-84
20600532-2	2010	Dieckol isolated from Ecklonia cava, brown algae, evidenced prominent inhibitory effect against alpha-glucosidase and alpha-amylase.	dieckol	0-7	sucrase isomaltase (alpha-glucosidase)	Mus musculus	96-113
20600532-3	2010	The IC(50) values of dieckol against alpha-glucosidase and alpha-amylase were 0.24 and 0.66 mM, respectively, which evidenced the higher activities than that of acarbose.	dieckol	21-28	sucrase isomaltase (alpha-glucosidase)	Mus musculus	37-54
20600532-7	2010	Therefore, these result indicated that dieckol might be a potent inhibitor for alpha-glucosidase and alpha-amylase.	dieckol	39-46	sucrase isomaltase (alpha-glucosidase)	Mus musculus	79-96
20799969-2	2010	Treatment of postprandial hyperglycemia can be achieved by inhibiting intestinal alpha-glucosidase, the key enzyme for oligosaccharide digestion and further glucose absorption.	Oligosaccharides	119-134	sucrase isomaltase (alpha-glucosidase)	Mus musculus	81-98
20799969-2	2010	Treatment of postprandial hyperglycemia can be achieved by inhibiting intestinal alpha-glucosidase, the key enzyme for oligosaccharide digestion and further glucose absorption.	Glucose	157-164	sucrase isomaltase (alpha-glucosidase)	Mus musculus	81-98
21072376-0	2010	Inhibitory effect of CuSO4 on alpha-glucosidase activity in ddY mice.	Copper Sulfate	21-26	sucrase isomaltase (alpha-glucosidase)	Mus musculus	30-47
20051258-0	2010	Insulin releasing and alpha-glucosidase inhibitory activity of ethyl acetate fraction of Acorus calamus in vitro and in vivo.	ethyl acetate	63-76	sucrase isomaltase (alpha-glucosidase)	Mus musculus	22-39
20051258-7	2010	In addition, ACE as a mixed-type inhibitor inhibited alpha-glucosidase activity in vitro with an IC(50) of 0.41 microg/ml, and 100mg/kg of it clearly reduced the increase of blood glucose levels after 5 g/kg amylum loading in normal mice.	Glucose	180-187	sucrase isomaltase (alpha-glucosidase)	Mus musculus	53-70
21072376-4	2010	On the basis of Lineweaver-Burk plots, both CuSO4 and ZnSO4 exhibited different modes of inhibition against alpha-glucosidase.	Copper Sulfate	44-49	sucrase isomaltase (alpha-glucosidase)	Mus musculus	108-125
21072376-1	2010	We investigated the effects of divalent alkaline earth and first-row transition metal and zinc ions on alpha-glucosidase activity in vitro and in vivo.	Metals	80-85	sucrase isomaltase (alpha-glucosidase)	Mus musculus	103-120
21072376-4	2010	On the basis of Lineweaver-Burk plots, both CuSO4 and ZnSO4 exhibited different modes of inhibition against alpha-glucosidase.	Zinc Sulfate	54-59	sucrase isomaltase (alpha-glucosidase)	Mus musculus	108-125
21072376-2	2010	CuSO4 and ZnSO4 exhibited a high alpha-glucosidase inhibitory effect in vitro.	Copper Sulfate	0-5	sucrase isomaltase (alpha-glucosidase)	Mus musculus	33-50
21072376-8	2010	These results indicate that CuSO4 suppresses disaccharide digestion by inhibiting alpha-glucosidase activity in the epithelium of the small intestine, suggesting that antidiabetic Cu complexes with some ligands have a similar action mechanism to that of alpha-glucosidase inhibitor, acarbose, currently used for clinical purposes.	Copper Sulfate	28-33	sucrase isomaltase (alpha-glucosidase)	Mus musculus	82-99
21072376-2	2010	CuSO4 and ZnSO4 exhibited a high alpha-glucosidase inhibitory effect in vitro.	Zinc Sulfate	10-15	sucrase isomaltase (alpha-glucosidase)	Mus musculus	33-50
21072376-8	2010	These results indicate that CuSO4 suppresses disaccharide digestion by inhibiting alpha-glucosidase activity in the epithelium of the small intestine, suggesting that antidiabetic Cu complexes with some ligands have a similar action mechanism to that of alpha-glucosidase inhibitor, acarbose, currently used for clinical purposes.	Copper Sulfate	28-33	sucrase isomaltase (alpha-glucosidase)	Mus musculus	254-271
21072376-8	2010	These results indicate that CuSO4 suppresses disaccharide digestion by inhibiting alpha-glucosidase activity in the epithelium of the small intestine, suggesting that antidiabetic Cu complexes with some ligands have a similar action mechanism to that of alpha-glucosidase inhibitor, acarbose, currently used for clinical purposes.	Disaccharides	45-57	sucrase isomaltase (alpha-glucosidase)	Mus musculus	82-99
21072376-3	2010	The IC(50) values of CuSO4 were 0.77 +- 0.01 (substrate; maltose) and 0.78 +- 0.01 (substrate; sucrose), and those of ZnSO4 were 5.49 +- 0.14 (substrate; maltose) and 4.70 +- 0.06 (substrate; sucrose) for yeast alpha-glucosidase.	Copper Sulfate	21-26	sucrase isomaltase (alpha-glucosidase)	Mus musculus	211-228
21072376-8	2010	These results indicate that CuSO4 suppresses disaccharide digestion by inhibiting alpha-glucosidase activity in the epithelium of the small intestine, suggesting that antidiabetic Cu complexes with some ligands have a similar action mechanism to that of alpha-glucosidase inhibitor, acarbose, currently used for clinical purposes.	Copper	28-30	sucrase isomaltase (alpha-glucosidase)	Mus musculus	82-99
19712270-0	2009	alpha-Glucosidase inhibitor acarbose and sequestome 1/A170/p62 deficient mice: A promising therapy and unique model for non-alcoholic fatty liver disease.	Acarbose	28-36	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
21072376-8	2010	These results indicate that CuSO4 suppresses disaccharide digestion by inhibiting alpha-glucosidase activity in the epithelium of the small intestine, suggesting that antidiabetic Cu complexes with some ligands have a similar action mechanism to that of alpha-glucosidase inhibitor, acarbose, currently used for clinical purposes.	Copper	28-30	sucrase isomaltase (alpha-glucosidase)	Mus musculus	254-271
21072376-8	2010	These results indicate that CuSO4 suppresses disaccharide digestion by inhibiting alpha-glucosidase activity in the epithelium of the small intestine, suggesting that antidiabetic Cu complexes with some ligands have a similar action mechanism to that of alpha-glucosidase inhibitor, acarbose, currently used for clinical purposes.	Acarbose	283-291	sucrase isomaltase (alpha-glucosidase)	Mus musculus	82-99
19539008-0	2009	Alpha-glucosidase inhibitory effect of anti-diabetic metal ions and their complexes.	Metals	53-58	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
19539008-1	2009	We found alpha-glucosidase inhibitory (alpha-GI) effect of metal ions and their complexes which showed the high blood glucose lowering effect in diabetic model animals.	Metals	59-64	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
19539008-1	2009	We found alpha-glucosidase inhibitory (alpha-GI) effect of metal ions and their complexes which showed the high blood glucose lowering effect in diabetic model animals.	Glucose	118-125	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
19482018-0	2009	Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice.	diphlorethohydroxycarmalol	0-26	sucrase isomaltase (alpha-glucosidase)	Mus musculus	82-99
19482018-1	2009	This study was designed to investigate whether diphlorethohydroxycarmalol (DPHC) may inhibit alpha-glucosidase and alpha-amylase activities, and alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice.	diphlorethohydroxycarmalol	47-73	sucrase isomaltase (alpha-glucosidase)	Mus musculus	93-110
19482018-1	2009	This study was designed to investigate whether diphlorethohydroxycarmalol (DPHC) may inhibit alpha-glucosidase and alpha-amylase activities, and alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice.	diphlorethohydroxycarmalol	75-79	sucrase isomaltase (alpha-glucosidase)	Mus musculus	93-110
19482018-2	2009	DPHC isolated from Ishige okamurae, a brown algae, evidenced prominent inhibitory effect against alpha-glucosidase and alpha-amylase.	diphlorethohydroxycarmalol	0-4	sucrase isomaltase (alpha-glucosidase)	Mus musculus	97-114
19482018-3	2009	The IC(50) values of DPHC against alpha-glucosidase and alpha-amylase were 0.16 and 0.53 mM, respectively, which evidenced the higher activities than that of acarbose.	diphlorethohydroxycarmalol	21-25	sucrase isomaltase (alpha-glucosidase)	Mus musculus	34-51
19482018-7	2009	Therefore, these result indicated that DPHC might be a potent inhibitor for alpha-glucosidase and alpha-amylase.	diphlorethohydroxycarmalol	39-43	sucrase isomaltase (alpha-glucosidase)	Mus musculus	76-93
19207582-0	2009	The alpha-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice.	Acarbose	32-40	sucrase isomaltase (alpha-glucosidase)	Mus musculus	4-21
19420711-2	2009	The simultaneous oral administration of the extract at a dose of 1.0 mg/mouse with maltose or sucrose inhibited the postprandial elevation of the plasma glucose and insulin levels and intestinal alpha-glucosidase activities in mice.	Maltose	83-90	sucrase isomaltase (alpha-glucosidase)	Mus musculus	195-212
19420711-2	2009	The simultaneous oral administration of the extract at a dose of 1.0 mg/mouse with maltose or sucrose inhibited the postprandial elevation of the plasma glucose and insulin levels and intestinal alpha-glucosidase activities in mice.	Sucrose	94-101	sucrase isomaltase (alpha-glucosidase)	Mus musculus	195-212
19420711-3	2009	In addition, the supply of a 0.01% solution of the extract as drinking water prevented the elevation of the plasma glucose level and intestinal alpha-glucosidase activities in type 1 diabetic mice.	Water	71-76	sucrase isomaltase (alpha-glucosidase)	Mus musculus	144-161
19207582-4	2009	Acarbose is an alpha-glucosidase inhibitor that improves insulin sensitivity and decreases postprandial hyperglycemia, and it is used to treat type 2 diabetes.	Acarbose	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	15-32
19208898-0	2009	Chronic administration of voglibose, an alpha-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice.	voglibose	26-35	sucrase isomaltase (alpha-glucosidase)	Mus musculus	40-57
19208898-1	2009	Administration of an alpha-glucosidase inhibitor, voglibose, increases the secretion of glucagon-like peptide (GLP)-1, a key modulator of pancreatic islet hormone secretion and glucose homeostasis.	voglibose	50-59	sucrase isomaltase (alpha-glucosidase)	Mus musculus	21-38
19263466-1	2009	BACKGROUND: Glycogen storage disease type II (GSDII) or Pompe disease is an inherited disease of glycogen metabolism caused by a lack of functional lysosomal acid alpha-glucosidase (GAA).	Glycogen	97-105	sucrase isomaltase (alpha-glucosidase)	Mus musculus	163-180
17572127-1	2007	Glycogen storage disease in the alpha-glucosidase knockout(6neo(-)/6neo(-)) (GAA KO) mouse, a model of Pompe disease, results in the pathologic accumulation of glycogen primarily within skeletal myocytes and cardiomyocytes.	Glycogen	160-168	sucrase isomaltase (alpha-glucosidase)	Mus musculus	32-49
17786952-3	2007	We used wild-type and GLUT2-null mice, to show that dietary sugars stimulate the expression of sucrase-isomaltase (SI) and L-pyruvate kinase (L-PK) by GLUT2-dependent mechanisms, whereas the expression of GLUT5 and SGLT1, did not rely on the presence of GLUT2.	Sugars	60-66	sucrase isomaltase (alpha-glucosidase)	Mus musculus	95-113
17786952-3	2007	We used wild-type and GLUT2-null mice, to show that dietary sugars stimulate the expression of sucrase-isomaltase (SI) and L-pyruvate kinase (L-PK) by GLUT2-dependent mechanisms, whereas the expression of GLUT5 and SGLT1, did not rely on the presence of GLUT2.	Sugars	60-66	sucrase isomaltase (alpha-glucosidase)	Mus musculus	115-117
17671744-0	2007	Ceftezole, a cephem antibiotic, is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity.	ceftezole	0-9	sucrase isomaltase (alpha-glucosidase)	Mus musculus	38-55
17671744-0	2007	Ceftezole, a cephem antibiotic, is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity.	cephem	13-19	sucrase isomaltase (alpha-glucosidase)	Mus musculus	38-55
17671744-1	2007	Using a high throughput-compatible assay to screen for potential alpha-glucosidase inhibitors, we found that the beta-lactam antibiotic ceftezole exhibited potent alpha-glucosidase inhibitory activity.	beta-Lactams	113-124	sucrase isomaltase (alpha-glucosidase)	Mus musculus	65-82
17671744-1	2007	Using a high throughput-compatible assay to screen for potential alpha-glucosidase inhibitors, we found that the beta-lactam antibiotic ceftezole exhibited potent alpha-glucosidase inhibitory activity.	beta-Lactams	113-124	sucrase isomaltase (alpha-glucosidase)	Mus musculus	163-180
17671744-1	2007	Using a high throughput-compatible assay to screen for potential alpha-glucosidase inhibitors, we found that the beta-lactam antibiotic ceftezole exhibited potent alpha-glucosidase inhibitory activity.	ceftezole	136-145	sucrase isomaltase (alpha-glucosidase)	Mus musculus	65-82
17671744-1	2007	Using a high throughput-compatible assay to screen for potential alpha-glucosidase inhibitors, we found that the beta-lactam antibiotic ceftezole exhibited potent alpha-glucosidase inhibitory activity.	ceftezole	136-145	sucrase isomaltase (alpha-glucosidase)	Mus musculus	163-180
17671744-2	2007	In in vitro alpha-glucosidase assays, ceftezole was shown to be a reversible, non-competitive inhibitor of yeast alpha-glucosidase with a Ki value of 5.78 x 10(-7) M when the enzyme mixture was pretreated with ceftezole.	ceftezole	38-47	sucrase isomaltase (alpha-glucosidase)	Mus musculus	12-29
17671744-2	2007	In in vitro alpha-glucosidase assays, ceftezole was shown to be a reversible, non-competitive inhibitor of yeast alpha-glucosidase with a Ki value of 5.78 x 10(-7) M when the enzyme mixture was pretreated with ceftezole.	ceftezole	38-47	sucrase isomaltase (alpha-glucosidase)	Mus musculus	113-130
17671744-2	2007	In in vitro alpha-glucosidase assays, ceftezole was shown to be a reversible, non-competitive inhibitor of yeast alpha-glucosidase with a Ki value of 5.78 x 10(-7) M when the enzyme mixture was pretreated with ceftezole.	ceftezole	210-219	sucrase isomaltase (alpha-glucosidase)	Mus musculus	113-130
17506980-10	2007	Reduction of glucose fluctuation by alpha-glucosidase inhibitor efficiently controlled the progression of atherosclerosis.	Glucose	13-20	sucrase isomaltase (alpha-glucosidase)	Mus musculus	36-53
17441354-8	2007	RESULTS: The water-soluble extract from PGL significantly inhibited, in the dose-dependent manner, the activities of alpha-glucosidase from small intestinal mucosa of diabetic mice.	Water	13-18	sucrase isomaltase (alpha-glucosidase)	Mus musculus	117-134
17585022-13	2007	Both sucrase-isomaltase and maltase-glucoamylase were active with limit-dextrin substrate.	Dextrins	72-79	sucrase isomaltase (alpha-glucosidase)	Mus musculus	5-23
17466947-0	2007	Carbohydrate/fat ratio in the diet alters histone acetylation on the sucrase-isomaltase gene and its expression in mouse small intestine.	Carbohydrates	0-12	sucrase isomaltase (alpha-glucosidase)	Mus musculus	69-87
17802886-10	2007	These effects of SHG were similar to those of acarbose, a kind of alpha-glucosidase inhibitors.	Acarbose	46-54	sucrase isomaltase (alpha-glucosidase)	Mus musculus	66-83
17441354-11	2007	CONCLUSION: The GPL water-soluble extract possesses the potential effect of inhibition on the alpha-glucosidase activity from the small intestinal mucosa of diabetic mouse.	Water	20-25	sucrase isomaltase (alpha-glucosidase)	Mus musculus	94-111
16163540-4	2006	HNF-1alpha, Cdx2 and GATA-4 are critical transcription factors in epithelial differentiation, and in combination they act as promoting factors of the sucrase-isomaltase (SI) gene, an enterocyte-specific differentiation marker which is distinctly downregulated after MTX treatment.	Methotrexate	266-269	sucrase isomaltase (alpha-glucosidase)	Mus musculus	150-168
16794329-3	2006	Taken together, these results suggest that the inhibitory effect of PsEx on alpha-glucosidase activity might contribute to delay in carbohydrate digestion and subsequent lowering of the blood glucose level, thereby leading to prevention and cure of diabetes.	Carbohydrates	132-144	sucrase isomaltase (alpha-glucosidase)	Mus musculus	76-93
16794329-3	2006	Taken together, these results suggest that the inhibitory effect of PsEx on alpha-glucosidase activity might contribute to delay in carbohydrate digestion and subsequent lowering of the blood glucose level, thereby leading to prevention and cure of diabetes.	Glucose	192-199	sucrase isomaltase (alpha-glucosidase)	Mus musculus	76-93
16163540-4	2006	HNF-1alpha, Cdx2 and GATA-4 are critical transcription factors in epithelial differentiation, and in combination they act as promoting factors of the sucrase-isomaltase (SI) gene, an enterocyte-specific differentiation marker which is distinctly downregulated after MTX treatment.	Methotrexate	266-269	sucrase isomaltase (alpha-glucosidase)	Mus musculus	170-172
15802852-0	2005	In vitro alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide.	Zinc	48-54	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
16510136-0	2006	Control of plasma glucose with alpha-glucosidase inhibitor attenuates oxidative stress and slows the progression of heart failure in mice.	Glucose	18-25	sucrase isomaltase (alpha-glucosidase)	Mus musculus	31-48
16713445-0	2006	alpha-Glucosidase inhibitors prevent diet-induced increases in intestinal sugar transport in diabetic mice.	Sugars	74-79	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
16713445-3	2006	alpha-Glucosidase inhibitors (AGIs) hinder digestion of complex carbohydrates and therefore alleviate postprandial glycemic excursions.	Carbohydrates	64-77	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
16713445-12	2006	alpha-Glucosidase inhibitor-inhibitable increases in total intestinal absorptive capacity for sugars were due to carbohydrate-induced increases in V(max) of glucose transport.	Sugars	94-100	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
16713445-12	2006	alpha-Glucosidase inhibitor-inhibitable increases in total intestinal absorptive capacity for sugars were due to carbohydrate-induced increases in V(max) of glucose transport.	Carbohydrates	113-125	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
16713445-12	2006	alpha-Glucosidase inhibitor-inhibitable increases in total intestinal absorptive capacity for sugars were due to carbohydrate-induced increases in V(max) of glucose transport.	Glucose	157-164	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
15797585-1	2005	Glycogen storage disease II is an inherited progressive muscular disease in which the lack of functional acid 1-4 alpha-glucosidase results in the accumulation of lysosomal glycogen.	Glycogen	173-181	sucrase isomaltase (alpha-glucosidase)	Mus musculus	114-131
15802852-1	2005	We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice.	picolinamide	188-200	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
15802852-2	2005	The Zn(II) complex showed strong alpha-glucosidase inhibitory activity greater by about eighty times (substrate: maltose) and forty times (substrate: sucrose) compared with acarbose.	Zinc	4-10	sucrase isomaltase (alpha-glucosidase)	Mus musculus	33-50
15802852-2	2005	The Zn(II) complex showed strong alpha-glucosidase inhibitory activity greater by about eighty times (substrate: maltose) and forty times (substrate: sucrose) compared with acarbose.	Maltose	113-120	sucrase isomaltase (alpha-glucosidase)	Mus musculus	33-50
15802852-2	2005	The Zn(II) complex showed strong alpha-glucosidase inhibitory activity greater by about eighty times (substrate: maltose) and forty times (substrate: sucrose) compared with acarbose.	Sucrose	150-157	sucrase isomaltase (alpha-glucosidase)	Mus musculus	33-50
15802852-2	2005	The Zn(II) complex showed strong alpha-glucosidase inhibitory activity greater by about eighty times (substrate: maltose) and forty times (substrate: sucrose) compared with acarbose.	Acarbose	173-181	sucrase isomaltase (alpha-glucosidase)	Mus musculus	33-50
15802852-0	2005	In vitro alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide.	6-methyl-2-picolinmethylamide	68-97	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
15802852-1	2005	We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice.	Zinc	48-54	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
15802852-1	2005	We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice.	6-methyl-2-picolinmethylamide	68-97	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
15802852-1	2005	We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice.	6mpa-ma	99-106	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
15802852-1	2005	We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice.	Glucose	139-146	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
15802852-1	2005	We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice.	Zinc	166-172	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
12115977-1	2002	Glycogen storage disease type II (GSD II) is an inherited progressive muscle disease in which lack of functional acid alpha-glucosidase (AGLU) results in lysosomal accumulation of glycogen.	Glycogen	180-188	sucrase isomaltase (alpha-glucosidase)	Mus musculus	118-135
12723600-3	2003	It was found that Acv-simmondsin was a potent competitive inhibitor of alpha-glucosidase with the Ki value of 0.69 microM and a mixed type inhibitor of alpha-amylase with the Ki and KI of 20.78 microM and 26.31 microM, respectively.	acv-simmondsin	18-32	sucrase isomaltase (alpha-glucosidase)	Mus musculus	71-88
12409258-0	2002	Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme.	Glycogen	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	62-79
11982484-9	2002	N-alkylated deoxynojirimycins (C(4)-C(18)) were evaluated for their inhibitory effects on ceramide-specific glucosyltransferase and glycoprotein-processing alpha-glucosidase.	1-Deoxynojirimycin	12-29	sucrase isomaltase (alpha-glucosidase)	Mus musculus	156-173
10915799-4	2000	The TRP-1 chain was able to fold into DTT-resistant conformations both in the presence or absence of alpha-glucosidase inhibitors, but folding occurred through different pathways.	Dithiothreitol	38-41	sucrase isomaltase (alpha-glucosidase)	Mus musculus	101-118
8877271-2	1996	Acarbose is a new antidiabetic drug which improves hyperglycemia by inhibiting alpha-glucosidase.	Acarbose	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	79-96
10814850-4	2000	Nodularin induces the activity of beta-D-glucuronidase, alpha-glucosidase, lysosomal esterase and N-acetyl-glucosaminidase and influenced on the labilization of endoplasmatic reticulum membranes.	nodularin	0-9	sucrase isomaltase (alpha-glucosidase)	Mus musculus	56-73
10222384-0	1999	Immunological analysis of beta-thalassemic mouse intestinal proteins reveals up-regulation of sucrase-isomaltase in response to iron overload.	Iron	128-132	sucrase isomaltase (alpha-glucosidase)	Mus musculus	94-112
9742458-0	1998	Effect of acarbose (alpha-glucosidase inhibitor) on disaccharase activity in small intestine in KK-Ay and ddY mice.	Acarbose	10-18	sucrase isomaltase (alpha-glucosidase)	Mus musculus	20-37
9742458-1	1998	The hypoglycemic effect and the alpha-glucosidase activity inhibition of acarbose (AC:alpha-glucosidase inhibitor) were investigated in normal and KK-Ay mice, an animal model of noninsulin-dependent diabetes mellitus (NIDDM).	Acarbose	73-81	sucrase isomaltase (alpha-glucosidase)	Mus musculus	32-49
9742458-1	1998	The hypoglycemic effect and the alpha-glucosidase activity inhibition of acarbose (AC:alpha-glucosidase inhibitor) were investigated in normal and KK-Ay mice, an animal model of noninsulin-dependent diabetes mellitus (NIDDM).	Acarbose	73-81	sucrase isomaltase (alpha-glucosidase)	Mus musculus	86-103
8625892-3	1996	We report here, with a combined in vitro and in vivo approach, that selective inhibition of islet lysosomal glycogenolytic acid glucan-1,4-alpha-glucosidase activity by the long-acting 1-deoxynojirimycin derivative emiglitate induces a profound suppression of nutrient-induced insulin release.	1-DEOXYNOJIRIMYCIN	185-203	sucrase isomaltase (alpha-glucosidase)	Mus musculus	139-156
8625892-3	1996	We report here, with a combined in vitro and in vivo approach, that selective inhibition of islet lysosomal glycogenolytic acid glucan-1,4-alpha-glucosidase activity by the long-acting 1-deoxynojirimycin derivative emiglitate induces a profound suppression of nutrient-induced insulin release.	emiglitate	215-225	sucrase isomaltase (alpha-glucosidase)	Mus musculus	139-156
8621356-3	1996	Nojirimycin A, nojirimycin B, deoxynojirimycin and D-gluco-delta-lactam showed potent or moderate inhibitory activities against alpha-glucosidase, beta-glucosidase and beta-mannosidase, but CP3068 and CP3069 in which the structures were related to D-gluco-delta-lactam showed no inhibitory activities.	nojirimycin a	0-13	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
8621356-3	1996	Nojirimycin A, nojirimycin B, deoxynojirimycin and D-gluco-delta-lactam showed potent or moderate inhibitory activities against alpha-glucosidase, beta-glucosidase and beta-mannosidase, but CP3068 and CP3069 in which the structures were related to D-gluco-delta-lactam showed no inhibitory activities.	mannojirimycin	15-28	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
8621356-3	1996	Nojirimycin A, nojirimycin B, deoxynojirimycin and D-gluco-delta-lactam showed potent or moderate inhibitory activities against alpha-glucosidase, beta-glucosidase and beta-mannosidase, but CP3068 and CP3069 in which the structures were related to D-gluco-delta-lactam showed no inhibitory activities.	1-Deoxynojirimycin	30-46	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
8621356-3	1996	Nojirimycin A, nojirimycin B, deoxynojirimycin and D-gluco-delta-lactam showed potent or moderate inhibitory activities against alpha-glucosidase, beta-glucosidase and beta-mannosidase, but CP3068 and CP3069 in which the structures were related to D-gluco-delta-lactam showed no inhibitory activities.	d-gluco-delta-lactam	51-71	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
8869751-6	1996	Alpha-glucosidase inhibitors such as epi-CPL and baicalein inhibited in vitro invasion and in vivo metastasis of mouse melanoma cells.	baicalein	49-58	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
34914943-0	2022	Loss of sucrase-isomaltase function increases acetate levels and improves metabolic health in Greenlandic cohorts.	Acetates	46-53	sucrase isomaltase (alpha-glucosidase)	Mus musculus	8-26
7827783-8	1994	Islets cultured in 2 g/l glucose showed elevated insulin response under basal and stimulating conditions during 2-3 wk, followed by a dramatic drop in insulin secretion [Day 7: bIS, 19.5 +/- 5.7 microU/50 microliters; sIS, 80.9 +/- 10.7 microU/50 microliters.	Glucose	25-32	sucrase isomaltase (alpha-glucosidase)	Mus musculus	218-221
7827783-11	1994	At 11 g/l glucose, functional and morphological islet alterations were accelerated [Day 7: bIS, 10.3 +/- 2.7 microU/50 microliters; sIS, 18.8 +/- 4.9 microU/50 microliters.	Glucose	10-17	sucrase isomaltase (alpha-glucosidase)	Mus musculus	132-135
7824805-9	1994	Acid phosphatase and alpha-glucosidase activities increased with the increase in ammonium acetate up to 20 mM.	ammonium acetate	81-97	sucrase isomaltase (alpha-glucosidase)	Mus musculus	21-38
8505144-4	1993	AA-2G"s effect was abrogated in the presence of castanospermine (alpha-glucosidase inhibitor) in the medium, indicating that the immunostimulation brought about by AA-2G is attributed to AsA released from the glucoside by alpha-glucosidase of cultured cells.	castanospermine	48-63	sucrase isomaltase (alpha-glucosidase)	Mus musculus	65-82
8505144-4	1993	AA-2G"s effect was abrogated in the presence of castanospermine (alpha-glucosidase inhibitor) in the medium, indicating that the immunostimulation brought about by AA-2G is attributed to AsA released from the glucoside by alpha-glucosidase of cultured cells.	castanospermine	48-63	sucrase isomaltase (alpha-glucosidase)	Mus musculus	222-239
8505144-4	1993	AA-2G"s effect was abrogated in the presence of castanospermine (alpha-glucosidase inhibitor) in the medium, indicating that the immunostimulation brought about by AA-2G is attributed to AsA released from the glucoside by alpha-glucosidase of cultured cells.	Ascorbic Acid	187-190	sucrase isomaltase (alpha-glucosidase)	Mus musculus	65-82
8505144-4	1993	AA-2G"s effect was abrogated in the presence of castanospermine (alpha-glucosidase inhibitor) in the medium, indicating that the immunostimulation brought about by AA-2G is attributed to AsA released from the glucoside by alpha-glucosidase of cultured cells.	Ascorbic Acid	187-190	sucrase isomaltase (alpha-glucosidase)	Mus musculus	222-239
8505144-4	1993	AA-2G"s effect was abrogated in the presence of castanospermine (alpha-glucosidase inhibitor) in the medium, indicating that the immunostimulation brought about by AA-2G is attributed to AsA released from the glucoside by alpha-glucosidase of cultured cells.	Glucosides	209-218	sucrase isomaltase (alpha-glucosidase)	Mus musculus	65-82
1907492-6	1991	Galactose stimulation of alpha-glucosidase and microvillus length expression was, however, fully maintained in mice fed the G + E diet.	Galactose	0-9	sucrase isomaltase (alpha-glucosidase)	Mus musculus	25-42
1723207-4	1991	It was found that two injections of suramin (0.18 mmol/kg) to normal NMRI mice at -24 and -2 h induced a moderate depression of the activities of islet acid amyloglucosidase (-22%) and acid phosphatase (-13%), whereas no effect was recorded for the activities of acid alpha-glucosidase, N-acetyl-beta-D-glucosaminidase and the non-lysosomal enzyme neutral alpha-glucosidase.	Suramin	36-43	sucrase isomaltase (alpha-glucosidase)	Mus musculus	268-285
1723207-4	1991	It was found that two injections of suramin (0.18 mmol/kg) to normal NMRI mice at -24 and -2 h induced a moderate depression of the activities of islet acid amyloglucosidase (-22%) and acid phosphatase (-13%), whereas no effect was recorded for the activities of acid alpha-glucosidase, N-acetyl-beta-D-glucosaminidase and the non-lysosomal enzyme neutral alpha-glucosidase.	Suramin	36-43	sucrase isomaltase (alpha-glucosidase)	Mus musculus	356-373
1723207-5	1991	Direct addition of different concentrations of suramin to islet homogenates showed that the drug was a potent inhibitor of acid amyloglucosidase and acid alpha-glucosidase at pH 4.0.	Suramin	47-54	sucrase isomaltase (alpha-glucosidase)	Mus musculus	154-171
1723207-6	1991	At pH 5.0, suramin induced a large increase in acid alpha-glucosidase activity, whereas acid amyloglucosidase and acid phosphatase were inhibited.	Suramin	11-18	sucrase isomaltase (alpha-glucosidase)	Mus musculus	52-69
32890659-0	2020	The mechanism of binding with the alpha-glucosidase in vitro and the evaluation on hypoglycemic effect in vivo: cocrystals involving synergism of gallic acid and conformer.	Gallic Acid	146-157	sucrase isomaltase (alpha-glucosidase)	Mus musculus	34-51
32890659-4	2020	Additionally, we examined the effect induced by cocrystallization of GA with each former on inhibition activity on alpha-glucosidase, a protein target involved in hypoglycemic effects.	Gallic Acid	69-71	sucrase isomaltase (alpha-glucosidase)	Mus musculus	115-132
32890659-6	2020	As predicted, cocrystallization improved oral bioavailability; AUC0- s of cocrystal A and B were 2.24-fold and 1.70-fold higher than that of GA. Interestingly, the alpha-glucosidase inhibition rate increased with cocrystal A (i.e., positive synergism) and decreased with cocrystal B (i.e., negative synergism) compared to GA alone.	Gallic Acid	141-143	sucrase isomaltase (alpha-glucosidase)	Mus musculus	164-181
32890659-9	2020	Molecular docking indicated that the hydrogen bonds between GA and CCF achieved binding with alpha-glucosidase in the form of supramolecular.	Hydrogen	37-45	sucrase isomaltase (alpha-glucosidase)	Mus musculus	93-110
32890659-9	2020	Molecular docking indicated that the hydrogen bonds between GA and CCF achieved binding with alpha-glucosidase in the form of supramolecular.	Gallic Acid	60-62	sucrase isomaltase (alpha-glucosidase)	Mus musculus	93-110
32890659-11	2020	Conversely, although cocrystal B displayed improved bioavailability compared with GA alone, the maximum hypoglycemic rate remained almost unchanged due to the negative synergism on alpha-glucosidase inhibition activity of GA and amino acetic acid.	Gallic Acid	222-224	sucrase isomaltase (alpha-glucosidase)	Mus musculus	181-198
7789651-0	1995	The pseudotetrasaccharide acarbose inhibits pancreatic islet glucan-1,4-alpha-glucosidase activity in parallel with a suppressive action on glucose-induced insulin release.	pseudotetrasaccharide	4-25	sucrase isomaltase (alpha-glucosidase)	Mus musculus	72-89
7789651-0	1995	The pseudotetrasaccharide acarbose inhibits pancreatic islet glucan-1,4-alpha-glucosidase activity in parallel with a suppressive action on glucose-induced insulin release.	Acarbose	26-34	sucrase isomaltase (alpha-glucosidase)	Mus musculus	72-89
7789651-2	1995	We observed that acarbose was a potent inhibitor of mouse islet lysosomal acid glucan-1,4-alpha-glucosidase activity, EC50 approximately 5 mumol/l, as well as of acid alpha-glucosidase activity.	Acarbose	17-25	sucrase isomaltase (alpha-glucosidase)	Mus musculus	90-107
7789651-2	1995	We observed that acarbose was a potent inhibitor of mouse islet lysosomal acid glucan-1,4-alpha-glucosidase activity, EC50 approximately 5 mumol/l, as well as of acid alpha-glucosidase activity.	Acarbose	17-25	sucrase isomaltase (alpha-glucosidase)	Mus musculus	167-184
8402678-0	1993	Inhibition of experimental metastasis by an alpha-glucosidase inhibitor, 1,6-epi-cyclophellitol.	cyclophellitol	73-95	sucrase isomaltase (alpha-glucosidase)	Mus musculus	44-61
8402678-2	1993	However, its structural analogue, 1,6-epi-cyclophellitol, inhibited alpha-glucosidase as well as beta-glucosidase, and inhibited experimental metastasis.	cyclophellitol	34-56	sucrase isomaltase (alpha-glucosidase)	Mus musculus	68-85
8402678-3	1993	1,6-Epi-cyclophellitol depressed alpha-glucosidase activity in cultured B16/F10 cells after 48 h of incubation.	cyclophellitol	0-22	sucrase isomaltase (alpha-glucosidase)	Mus musculus	33-50
8402678-4	1993	Preincubation of B16/F10 cells for 48 h with 1,6-epi-cyclophellitol inhibited invasion of the cells in a Boyden chamber assay at the doses effective in inhibiting alpha-glucosidase in situ.	cyclophellitol	45-67	sucrase isomaltase (alpha-glucosidase)	Mus musculus	163-180
7506286-0	1993	Islet glucan-1,4-alpha-glucosidase: differential influence on insulin secretion induced by glucose and isobutylmethylxanthine in mice.	Glucose	91-98	sucrase isomaltase (alpha-glucosidase)	Mus musculus	17-34
7506286-0	1993	Islet glucan-1,4-alpha-glucosidase: differential influence on insulin secretion induced by glucose and isobutylmethylxanthine in mice.	1-Methyl-3-isobutylxanthine	103-125	sucrase isomaltase (alpha-glucosidase)	Mus musculus	17-34
7506286-1	1993	In previous in-vivo studies we have presented indirect evidence for the involvement of islet acid glucan-1,4-alpha-glucosidase (acid amyloglucosidase), a lysosomal glycogen-hydrolysing enzyme, in certain insulin secretory processes.	Glycogen	164-172	sucrase isomaltase (alpha-glucosidase)	Mus musculus	109-126
2112030-7	1990	Experiments in which endogenous testosterone was depleted in rats demonstrated the dependence of epididymal alpha-glucosidase on androgen, albeit with a low sensitivity.	Testosterone	32-44	sucrase isomaltase (alpha-glucosidase)	Mus musculus	108-125
33798849-0	2021	alpha-Glucosidase inhibitory and anti-inflammatory activities of dammarane triterpenoids from the leaves of Cyclocarya paliurus.	dammarane	65-74	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
33798849-0	2021	alpha-Glucosidase inhibitory and anti-inflammatory activities of dammarane triterpenoids from the leaves of Cyclocarya paliurus.	Triterpenes	75-88	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
33798849-7	2021	Dammarane glucoside 2 exhibited the strongest alpha-glucosidase inhibitory and anti-inflammatory activities.	dammarane glucoside	0-19	sucrase isomaltase (alpha-glucosidase)	Mus musculus	46-63
33798849-9	2021	In summary, C. paliurus leaves showed marked alpha-glucosidase inhibitory and anti-inflammatory activities, and dammarane saponins are responsible for regulating alpha-glucosidase, inflammatory mediators, and mRNA and the protein expression of proinflammatory cytokines, which could be meaningful for discovering new antidiabetic agents.	dammarane saponins	112-130	sucrase isomaltase (alpha-glucosidase)	Mus musculus	162-179
34666184-0	2022	Peptide Conjugates of 18beta-Glycyrrhetinic Acid as Potent Inhibitors of alpha-Glucosidase and AGEs-Induced Oxidation.	18alpha-glycyrrhetinic acid	22-48	sucrase isomaltase (alpha-glucosidase)	Mus musculus	73-90
34666184-5	2022	The most active 18beta-GA-peptide conjugates 5 (18beta-GA-Cys1-Tyr2-Gly3) and 8 (18beta-GA-Pro1-Tyr2-Gly3) exhibited several fold potent alpha-glucosidase inhibitory activity (IC50 values 20-28 muM), as compared to standard drug acarbose (IC50 = 875.8 +- 2.10 microM).	Acarbose	229-237	sucrase isomaltase (alpha-glucosidase)	Mus musculus	137-154
34666184-14	2022	Dual inhibition of alpha-glucosidase enzyme, and AGEs-induced NO  production by 18beta-GA-peptide conjugates pave the way for further research in anti-diabetic drug discovery.	ga-peptide	87-97	sucrase isomaltase (alpha-glucosidase)	Mus musculus	19-36
34914943-1	2022	BACKGROUND & AIMS: The sucrase-isomaltase (SI) c.273_274delAG loss-of-function variant is common in Arctic populations and causes congenital sucrase-isomaltase deficiency, an inability to breakdown and absorb sucrose and isomaltose.	Sucrose	209-216	sucrase isomaltase (alpha-glucosidase)	Mus musculus	23-41
34914943-1	2022	BACKGROUND & AIMS: The sucrase-isomaltase (SI) c.273_274delAG loss-of-function variant is common in Arctic populations and causes congenital sucrase-isomaltase deficiency, an inability to breakdown and absorb sucrose and isomaltose.	Sucrose	209-216	sucrase isomaltase (alpha-glucosidase)	Mus musculus	43-45
34914943-1	2022	BACKGROUND & AIMS: The sucrase-isomaltase (SI) c.273_274delAG loss-of-function variant is common in Arctic populations and causes congenital sucrase-isomaltase deficiency, an inability to breakdown and absorb sucrose and isomaltose.	Isomaltose	221-231	sucrase isomaltase (alpha-glucosidase)	Mus musculus	23-41
34914943-1	2022	BACKGROUND & AIMS: The sucrase-isomaltase (SI) c.273_274delAG loss-of-function variant is common in Arctic populations and causes congenital sucrase-isomaltase deficiency, an inability to breakdown and absorb sucrose and isomaltose.	Isomaltose	221-231	sucrase isomaltase (alpha-glucosidase)	Mus musculus	43-45
34914943-9	2022	CONCLUSIONS: These results suggest that sucrase-isomaltase constitutes a promising drug target for improvement of metabolic health, and that the health benefits are mediated by reduced dietary sucrose uptake and possibly also by higher levels of circulating acetate.	Sucrose	193-200	sucrase isomaltase (alpha-glucosidase)	Mus musculus	40-58
34914943-9	2022	CONCLUSIONS: These results suggest that sucrase-isomaltase constitutes a promising drug target for improvement of metabolic health, and that the health benefits are mediated by reduced dietary sucrose uptake and possibly also by higher levels of circulating acetate.	Acetates	258-265	sucrase isomaltase (alpha-glucosidase)	Mus musculus	40-58
34186120-8	2021	Among the identified compounds, rosmarinic acid, caffeic acid, oleanolic acid, and ursolic acid showed high catalytic activity of alpha amylase and alpha-glucosidase.	rosmarinic acid	32-47	sucrase isomaltase (alpha-glucosidase)	Mus musculus	130-165
34678724-7	2021	Moreover, AMPK, PPARgamma, alpha-amylase, and alpha-glucosidase were found to be the potential targets for simulating binds with gamma-mangostin after molecular docking.	gamma-mangostin	129-144	sucrase isomaltase (alpha-glucosidase)	Mus musculus	46-63
34678724-8	2021	To validate the docking results, the inhibitory potency of gamma-mangostin againstalpha-amylase/alpha-glucosidase was higher than Acarbose via enzymatic assay.	gamma-mangostin	59-74	sucrase isomaltase (alpha-glucosidase)	Mus musculus	96-113
34678724-10	2021	Taken together, the results showed that gamma-mangostin exerts anti-hyperglycemic activity through promoting glucose uptake and reducing saccharide digestion by inhibition of alpha-amylase/alpha-glucosidase with insulin sensitization, suggesting that gamma-mangostin could be a new clue for drug discovery and development to treat diabetes.	gamma-mangostin	40-55	sucrase isomaltase (alpha-glucosidase)	Mus musculus	189-206
34678724-10	2021	Taken together, the results showed that gamma-mangostin exerts anti-hyperglycemic activity through promoting glucose uptake and reducing saccharide digestion by inhibition of alpha-amylase/alpha-glucosidase with insulin sensitization, suggesting that gamma-mangostin could be a new clue for drug discovery and development to treat diabetes.	gamma-mangostin	251-266	sucrase isomaltase (alpha-glucosidase)	Mus musculus	189-206
34805250-5	2021	W-CCP and RPPs had a significant positive free radical-scavenging capacities and inhibitory activities on alpha-glucosidase and alpha-amylase.	w-ccp	0-5	sucrase isomaltase (alpha-glucosidase)	Mus musculus	106-123
34608550-0	2021	Synthesis of 1,2,3,triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro alpha-glucosidase enzyme inhibition studies.	1,2,3,triazole	13-27	sucrase isomaltase (alpha-glucosidase)	Mus musculus	112-129
34608550-0	2021	Synthesis of 1,2,3,triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro alpha-glucosidase enzyme inhibition studies.	Hydrochlorothiazide	50-69	sucrase isomaltase (alpha-glucosidase)	Mus musculus	112-129
34608550-7	2021	alpha-Glucosidase inhibitor drug acarbose (IC50 = 875.75 +- 2.08 muM) was used as the standard.	Acarbose	33-41	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
34186120-8	2021	Among the identified compounds, rosmarinic acid, caffeic acid, oleanolic acid, and ursolic acid showed high catalytic activity of alpha amylase and alpha-glucosidase.	caffeic acid	49-61	sucrase isomaltase (alpha-glucosidase)	Mus musculus	130-165
34186120-8	2021	Among the identified compounds, rosmarinic acid, caffeic acid, oleanolic acid, and ursolic acid showed high catalytic activity of alpha amylase and alpha-glucosidase.	Oleanolic Acid	63-77	sucrase isomaltase (alpha-glucosidase)	Mus musculus	130-165
34186120-8	2021	Among the identified compounds, rosmarinic acid, caffeic acid, oleanolic acid, and ursolic acid showed high catalytic activity of alpha amylase and alpha-glucosidase.	ursolic acid	83-95	sucrase isomaltase (alpha-glucosidase)	Mus musculus	130-165
34455958-0	2022	Feruloyl Sucrose Esters: Potent and Selective Inhibitors of alpha-glucosidase and alpha-amylase.	feruloyl sucrose esters	0-23	sucrase isomaltase (alpha-glucosidase)	Mus musculus	60-77
34455958-5	2022	FSEs were evaluated for their in vitro inhibition of starch and oligosaccharide digesting enzymes alpha-glucosidase and alpha-amylase followed by in silico docking studies to identify the binding modes.	Oligosaccharides	64-79	sucrase isomaltase (alpha-glucosidase)	Mus musculus	98-115
34455958-9	2022	From the in vitro studies, the position and number of the feruloyl substituents on the sucrose core, the aromatic "OH" group, and the diisopropylidene bridges were key determinants of the % inhibition of alpha-glucosidase and alpha-amylase.	Sucrose	87-94	sucrase isomaltase (alpha-glucosidase)	Mus musculus	204-221
34455958-9	2022	From the in vitro studies, the position and number of the feruloyl substituents on the sucrose core, the aromatic "OH" group, and the diisopropylidene bridges were key determinants of the % inhibition of alpha-glucosidase and alpha-amylase.	diisopropylidene	134-150	sucrase isomaltase (alpha-glucosidase)	Mus musculus	204-221
35483282-7	2022	Catechin, epicatechin, rutin, ferulic acid, and kaempferitrin with high affinity capacity indicated strong inhibiting effect on alpha-glucosidase and alpha-amylase.	Catechin	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
34068075-12	2021	Moreover, the saponins cake extract showed a strong inhibitory action on alpha-amylase and alpha-glucosidase, which is also higher than that of Argan oil.	Saponins	14-22	sucrase isomaltase (alpha-glucosidase)	Mus musculus	91-108
34068075-12	2021	Moreover, the saponins cake extract showed a strong inhibitory action on alpha-amylase and alpha-glucosidase, which is also higher than that of Argan oil.	argan oil	144-153	sucrase isomaltase (alpha-glucosidase)	Mus musculus	91-108
34141163-6	2021	Lupeol showed noticeable inhibitory activities on alpha-glucosidase and alpha-amylase.	lupeol	0-6	sucrase isomaltase (alpha-glucosidase)	Mus musculus	50-67
34141163-7	2021	The half-maximal inhibitory concentrations (IC50) of lupeol on alpha-glucosidase and alpha-amylase were 46.23 +- 9.03 and 84.13 +- 6.82 muM, respectively, which were more significantly effective than those of acarbose, which is a positive control.	lupeol	53-59	sucrase isomaltase (alpha-glucosidase)	Mus musculus	63-80
35483282-7	2022	Catechin, epicatechin, rutin, ferulic acid, and kaempferitrin with high affinity capacity indicated strong inhibiting effect on alpha-glucosidase and alpha-amylase.	Catechin	10-21	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
35483282-7	2022	Catechin, epicatechin, rutin, ferulic acid, and kaempferitrin with high affinity capacity indicated strong inhibiting effect on alpha-glucosidase and alpha-amylase.	Rutin	23-28	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
35483282-7	2022	Catechin, epicatechin, rutin, ferulic acid, and kaempferitrin with high affinity capacity indicated strong inhibiting effect on alpha-glucosidase and alpha-amylase.	ferulic acid	30-42	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
35483282-7	2022	Catechin, epicatechin, rutin, ferulic acid, and kaempferitrin with high affinity capacity indicated strong inhibiting effect on alpha-glucosidase and alpha-amylase.	lespenefril	48-61	sucrase isomaltase (alpha-glucosidase)	Mus musculus	128-145
35490401-0	2022	Lariciresinol displays anti-diabetic activity through inhibition of alpha-glucosidase and activation and enhancement of insulin signaling.	lariciresinol	0-13	sucrase isomaltase (alpha-glucosidase)	Mus musculus	68-85
35447553-3	2022	The prethanol extract of saechalssal (SPE) showed greater alpha-glucosidase inhibitory activity in vitro and a more significant lowering of the postprandial blood glucose levels in normal mice compared to its water extract (SWE).	saechalssal	25-36	sucrase isomaltase (alpha-glucosidase)	Mus musculus	58-75
34040519-9	2021	In alpha-glucosidase inhibitory activity, maximum inhibition was observed in DCM and chloroform extracts of SBGC (>85% inhibition at 25% concentration), followed by KBGC (>80% inhibition at 25% concentration), JBGC and GC.	Methylene Chloride	77-80	sucrase isomaltase (alpha-glucosidase)	Mus musculus	3-20
35066100-3	2022	We used 2-deoxyglucose (2DG) as a glycolysis inhibitor and acarbose (ACA), a specific alpha-glucosidase inhibitor, to decrease glucose uptake.	Acarbose	59-67	sucrase isomaltase (alpha-glucosidase)	Mus musculus	86-103
35066100-3	2022	We used 2-deoxyglucose (2DG) as a glycolysis inhibitor and acarbose (ACA), a specific alpha-glucosidase inhibitor, to decrease glucose uptake.	Acarbose	69-72	sucrase isomaltase (alpha-glucosidase)	Mus musculus	86-103
35066100-3	2022	We used 2-deoxyglucose (2DG) as a glycolysis inhibitor and acarbose (ACA), a specific alpha-glucosidase inhibitor, to decrease glucose uptake.	Glucose	127-134	sucrase isomaltase (alpha-glucosidase)	Mus musculus	86-103
35270046-1	2022	and Its Terpenoids: alpha-Glucosidase and SGLT1 Inhibitors.	Terpenes	8-18	sucrase isomaltase (alpha-glucosidase)	Mus musculus	20-37
2568363-1	1989	Colchicine- and vinblastine-induced depolymerization of microtubules (MTs) in the intestinal epithelium of rats and mice resulted in significant delivery of three apical membrane proteins (alkaline phosphatase, sucrase-isomaltase, and aminopeptidase N) to the basolateral membrane domain.	Colchicine	0-10	sucrase isomaltase (alpha-glucosidase)	Mus musculus	211-229
2568363-1	1989	Colchicine- and vinblastine-induced depolymerization of microtubules (MTs) in the intestinal epithelium of rats and mice resulted in significant delivery of three apical membrane proteins (alkaline phosphatase, sucrase-isomaltase, and aminopeptidase N) to the basolateral membrane domain.	Vinblastine	16-27	sucrase isomaltase (alpha-glucosidase)	Mus musculus	211-229
3100764-0	1987	Chronic effects of an alpha-glucosidase inhibitor (Bay o 1248) on intestinal disaccharidase activity in normal and diabetic mice.	emiglitate	51-61	sucrase isomaltase (alpha-glucosidase)	Mus musculus	22-39
2434278-3	1986	We found that the increase in insulin secretion during a 4 hr incubation period in the presence of 16.7 mM glucose was accompanied by an increase in islet activities of the lysosomal enzymes acid amyloglucosidase and acid alpha-glucosidase.	Glucose	107-114	sucrase isomaltase (alpha-glucosidase)	Mus musculus	222-239
929107-7	1977	Intestinal amylase levels did not change during the experiments, but intestinal alpha-glucosidase activity increased significantly in the CDCA-treated animals.	Chenodeoxycholic Acid	138-142	sucrase isomaltase (alpha-glucosidase)	Mus musculus	80-97
35458714-0	2022	Binding Interaction of Betulinic Acid to alpha-Glucosidase and Its Alleviation on Postprandial Hyperglycemia.	betulinic acid	23-37	sucrase isomaltase (alpha-glucosidase)	Mus musculus	41-58
35458714-2	2022	In the present study, we reported the binding interaction of betulinic acid (BA), a pentacyclic triterpene widely distributed in nature, on alpha-glucosidase and its alleviation on postprandial hyperglycemia.	betulinic acid	61-75	sucrase isomaltase (alpha-glucosidase)	Mus musculus	140-157
35458714-2	2022	In the present study, we reported the binding interaction of betulinic acid (BA), a pentacyclic triterpene widely distributed in nature, on alpha-glucosidase and its alleviation on postprandial hyperglycemia.	betulinic acid	77-79	sucrase isomaltase (alpha-glucosidase)	Mus musculus	140-157
35458714-2	2022	In the present study, we reported the binding interaction of betulinic acid (BA), a pentacyclic triterpene widely distributed in nature, on alpha-glucosidase and its alleviation on postprandial hyperglycemia.	Triterpenes	96-106	sucrase isomaltase (alpha-glucosidase)	Mus musculus	140-157
35458714-3	2022	BA was verified to exhibit a strong inhibitory effect against alpha-glucosidase with an IC50 value of 16.83 +- 1.16 muM.	betulinic acid	0-2	sucrase isomaltase (alpha-glucosidase)	Mus musculus	62-79
35458714-6	2022	BA showed a non-competitive inhibition on alpha-glucosidase.	betulinic acid	0-2	sucrase isomaltase (alpha-glucosidase)	Mus musculus	42-59
35458714-8	2022	Molecular docking and MD simulation revealed that BA bound to the active site of alpha-glucosidase mainly due to the van der Waals force and hydrogen bond, and then changed the micro-environment and secondary structure of alpha-glucosidase.	betulinic acid	50-52	sucrase isomaltase (alpha-glucosidase)	Mus musculus	81-98
35458714-8	2022	Molecular docking and MD simulation revealed that BA bound to the active site of alpha-glucosidase mainly due to the van der Waals force and hydrogen bond, and then changed the micro-environment and secondary structure of alpha-glucosidase.	betulinic acid	50-52	sucrase isomaltase (alpha-glucosidase)	Mus musculus	222-239
35458714-8	2022	Molecular docking and MD simulation revealed that BA bound to the active site of alpha-glucosidase mainly due to the van der Waals force and hydrogen bond, and then changed the micro-environment and secondary structure of alpha-glucosidase.	Hydrogen	141-149	sucrase isomaltase (alpha-glucosidase)	Mus musculus	81-98
35458714-9	2022	Free energy decomposition indicated amino acid residues such as PHE155, PHE175, HIE277, PHE298, GLU302, TRY311 and ASP347 of alpha-glucosidase at the binding pocket had strong interactions with BA, while LYS153, ARG210, ARG310, ARG354 and ARG437 showed a negative contribution to binding affinity between BA and alpha-glucosidase.	hie277	80-86	sucrase isomaltase (alpha-glucosidase)	Mus musculus	125-142
35458714-9	2022	Free energy decomposition indicated amino acid residues such as PHE155, PHE175, HIE277, PHE298, GLU302, TRY311 and ASP347 of alpha-glucosidase at the binding pocket had strong interactions with BA, while LYS153, ARG210, ARG310, ARG354 and ARG437 showed a negative contribution to binding affinity between BA and alpha-glucosidase.	betulinic acid	194-196	sucrase isomaltase (alpha-glucosidase)	Mus musculus	125-142
35458714-9	2022	Free energy decomposition indicated amino acid residues such as PHE155, PHE175, HIE277, PHE298, GLU302, TRY311 and ASP347 of alpha-glucosidase at the binding pocket had strong interactions with BA, while LYS153, ARG210, ARG310, ARG354 and ARG437 showed a negative contribution to binding affinity between BA and alpha-glucosidase.	betulinic acid	305-307	sucrase isomaltase (alpha-glucosidase)	Mus musculus	125-142
2684158-1	1989	We measured the synthesis of diacylglycerol de novo in normal NIH/3T3 fibroblasts and in cells transformed by ras, src, sis and abl oncogenes.	Diglycerides	29-43	sucrase isomaltase (alpha-glucosidase)	Mus musculus	22-25
34028050-2	2021	Herein, screening and identifying of alpha-glucosidase inhibitors from hawthorn berry were conducted, and the results showed polyphenols mainly containing quercetin (74.58%) and hyperioside (9.58%) were responsible for its bioactivity.	Polyphenols	125-136	sucrase isomaltase (alpha-glucosidase)	Mus musculus	37-54
34028050-2	2021	Herein, screening and identifying of alpha-glucosidase inhibitors from hawthorn berry were conducted, and the results showed polyphenols mainly containing quercetin (74.58%) and hyperioside (9.58%) were responsible for its bioactivity.	Quercetin	155-164	sucrase isomaltase (alpha-glucosidase)	Mus musculus	37-54
34028050-2	2021	Herein, screening and identifying of alpha-glucosidase inhibitors from hawthorn berry were conducted, and the results showed polyphenols mainly containing quercetin (74.58%) and hyperioside (9.58%) were responsible for its bioactivity.	hyperioside	178-189	sucrase isomaltase (alpha-glucosidase)	Mus musculus	37-54
34040519-9	2021	In alpha-glucosidase inhibitory activity, maximum inhibition was observed in DCM and chloroform extracts of SBGC (>85% inhibition at 25% concentration), followed by KBGC (>80% inhibition at 25% concentration), JBGC and GC.	Chloroform	85-95	sucrase isomaltase (alpha-glucosidase)	Mus musculus	3-20
33430115-2	2021	This work aims to study for the first time the potential inhibitory effect of this plant hydroethanolic extract on alpha-amylase and alpha-glucosidase activities using in vitro methods and its antidiabetic and antihyperglycemic activities using alloxan-induced diabetic mice as a model for experimental diabetes.	hydroethanolic extract	89-111	sucrase isomaltase (alpha-glucosidase)	Mus musculus	133-150
33924088-5	2021	Live Probio65 and Probio-093 inhibited alpha-glucosidase and alpha-amylase, respectively (p < 0.05).	probio-093	18-28	sucrase isomaltase (alpha-glucosidase)	Mus musculus	39-56
33339666-0	2021	Synthesis, crystal structure and Hirshfeld Surface analysis of benzamide derivatives of thiourea as potent inhibitors of alpha-glucosidase in-vitro.	benzamide	63-72	sucrase isomaltase (alpha-glucosidase)	Mus musculus	121-138
33339666-0	2021	Synthesis, crystal structure and Hirshfeld Surface analysis of benzamide derivatives of thiourea as potent inhibitors of alpha-glucosidase in-vitro.	Thiourea	88-96	sucrase isomaltase (alpha-glucosidase)	Mus musculus	121-138
33339666-1	2021	Benzamide based structural analogues 1-15 were synthesized, and evaluated for alpha-glucosidase inhibition activity in vitro for the first time.	benzamide	0-9	sucrase isomaltase (alpha-glucosidase)	Mus musculus	78-95
33339666-3	2021	However, to the best of our knowledge we are reporting alpha-glucosidase inhibitory activity of these bezamide derivatives of thiourea for the first time.	bezamide	102-110	sucrase isomaltase (alpha-glucosidase)	Mus musculus	55-72
33339666-3	2021	However, to the best of our knowledge we are reporting alpha-glucosidase inhibitory activity of these bezamide derivatives of thiourea for the first time.	Thiourea	126-134	sucrase isomaltase (alpha-glucosidase)	Mus musculus	55-72
33339666-4	2021	Compounds 1, 3, 6-8, 10-14 were found to be potent inhibitors of alpha-glucosidase within IC50 range of 20.44-333.41 microM, in comparison to the standard inhibitor, acarbose (IC50 = 875.75 +- 2.08 microM).	Acarbose	166-174	sucrase isomaltase (alpha-glucosidase)	Mus musculus	65-82
33995021-9	2021	When compared to the aqueous extract, the essential oil showed superior radical scavenging activity, particularly for  NO, as well as greater inhibitory potency against alpha-amylase and alpha-glucosidase (IC50 = 0.01 mg/ml and 0.11 mg/ml, respectively).	Oils, Volatile	42-55	sucrase isomaltase (alpha-glucosidase)	Mus musculus	187-204
32763730-0	2021	Enhanced antioxidant, anti-inflammatory and alpha-glucosidase inhibitory activities of citrus hesperidin by acid-catalyzed hydrolysis.	Hesperidin	94-104	sucrase isomaltase (alpha-glucosidase)	Mus musculus	44-61
32736047-10	2020	TF and naringin demonstrated a certain inhibitory effect on alpha-glucosidase and a weaker inhibitory effect on alpha-amylase.	tf	0-2	sucrase isomaltase (alpha-glucosidase)	Mus musculus	60-77
32736047-10	2020	TF and naringin demonstrated a certain inhibitory effect on alpha-glucosidase and a weaker inhibitory effect on alpha-amylase.	naringin	7-15	sucrase isomaltase (alpha-glucosidase)	Mus musculus	60-77
32034442-0	2020	The glucose-lowering effects of alpha-glucosidase inhibitor require a bile acid signal in mice.	Glucose	4-11	sucrase isomaltase (alpha-glucosidase)	Mus musculus	32-49
32599415-0	2020	Conditioning with slowly digestible starch diets in mice reduces jejunal alpha-glucosidase activity and glucogenesis from a digestible starch feeding.	Starch	36-42	sucrase isomaltase (alpha-glucosidase)	Mus musculus	73-90
32599415-5	2020	RESULTS: Conditioning of the small intestine with the slowly digestible starches for 7 d reduced jejunal alpha-glucosidase and sucrase activities, as well as glucose absorption for the slowly digestible starch slower group (P < 0.01).	Starch	72-80	sucrase isomaltase (alpha-glucosidase)	Mus musculus	105-122
32599415-5	2020	RESULTS: Conditioning of the small intestine with the slowly digestible starches for 7 d reduced jejunal alpha-glucosidase and sucrase activities, as well as glucose absorption for the slowly digestible starch slower group (P < 0.01).	Starch	72-78	sucrase isomaltase (alpha-glucosidase)	Mus musculus	105-122
32599415-6	2020	A correlative relationship was found between glucose absorption from a cornstarch test feeding given at d 7 and jejunal alpha-glucosidase and sucrase activities (R2 = 0.64; 0.67).	Glucose	45-52	sucrase isomaltase (alpha-glucosidase)	Mus musculus	120-137
32599415-8	2020	CONCLUSIONS: Decreased glucogenesis from a digestible starch feeding was found in mice conditioned on slowly digestible starch diets, suggesting that a dietary approach incorporating slowly digestible starches may change alpha-glucosidase activities to moderate glucose absorption rate.	Starch	54-60	sucrase isomaltase (alpha-glucosidase)	Mus musculus	221-238
32599415-8	2020	CONCLUSIONS: Decreased glucogenesis from a digestible starch feeding was found in mice conditioned on slowly digestible starch diets, suggesting that a dietary approach incorporating slowly digestible starches may change alpha-glucosidase activities to moderate glucose absorption rate.	Starch	120-126	sucrase isomaltase (alpha-glucosidase)	Mus musculus	221-238
32599415-8	2020	CONCLUSIONS: Decreased glucogenesis from a digestible starch feeding was found in mice conditioned on slowly digestible starch diets, suggesting that a dietary approach incorporating slowly digestible starches may change alpha-glucosidase activities to moderate glucose absorption rate.	Starch	201-209	sucrase isomaltase (alpha-glucosidase)	Mus musculus	221-238
32527456-6	2020	Moreover, HT-ONO2 shown definite vasodilation and alpha-glucosidase inhibition activity in vitro.	3,4-dihydroxyphenylethanol	10-12	sucrase isomaltase (alpha-glucosidase)	Mus musculus	50-67
32527456-6	2020	Moreover, HT-ONO2 shown definite vasodilation and alpha-glucosidase inhibition activity in vitro.	epalrestat	13-17	sucrase isomaltase (alpha-glucosidase)	Mus musculus	50-67
32806121-1	2020	1-Deoxynojirimycin (1-DNJ) is the major effective component of mulberry leaves, exhibiting inhibitory activity against alpha-glucosidase.	1-Deoxynojirimycin	0-18	sucrase isomaltase (alpha-glucosidase)	Mus musculus	119-136
32806121-1	2020	1-Deoxynojirimycin (1-DNJ) is the major effective component of mulberry leaves, exhibiting inhibitory activity against alpha-glucosidase.	1-Deoxynojirimycin	20-25	sucrase isomaltase (alpha-glucosidase)	Mus musculus	119-136
32806121-3	2020	In this study, a combination of dietary 5,6,7-trihydroxy-flavonoid aglycones with 1-DNJ showed synergistic inhibitory activity against maltase of mice alpha-glucosidase and recombinant C- and N-termini of maltase-glucoamylase (MGAM) and baicalein with 1-DNJ exhibited the strongest synergistic effect.	5,6,7-trihydroxy-flavonoid aglycones	40-76	sucrase isomaltase (alpha-glucosidase)	Mus musculus	151-168
32722136-4	2020	The potential as alpha-glucosidase inhibitors of products was evaluated with oral sucrose and lactose tolerance (OSTT and OLTT, respectively) and intestinal sucrose hydrolysis (ISH) tests; the potential as SGLT-1 inhibitors was evaluated using oral glucose tolerance (OGTT), intestinal glucose absorption (IGA), and urinary glucose excretion (UGE) tests.	Sucrose	82-89	sucrase isomaltase (alpha-glucosidase)	Mus musculus	17-34
32722136-4	2020	The potential as alpha-glucosidase inhibitors of products was evaluated with oral sucrose and lactose tolerance (OSTT and OLTT, respectively) and intestinal sucrose hydrolysis (ISH) tests; the potential as SGLT-1 inhibitors was evaluated using oral glucose tolerance (OGTT), intestinal glucose absorption (IGA), and urinary glucose excretion (UGE) tests.	Lactose	94-101	sucrase isomaltase (alpha-glucosidase)	Mus musculus	17-34
32722136-4	2020	The potential as alpha-glucosidase inhibitors of products was evaluated with oral sucrose and lactose tolerance (OSTT and OLTT, respectively) and intestinal sucrose hydrolysis (ISH) tests; the potential as SGLT-1 inhibitors was evaluated using oral glucose tolerance (OGTT), intestinal glucose absorption (IGA), and urinary glucose excretion (UGE) tests.	Sucrose	157-164	sucrase isomaltase (alpha-glucosidase)	Mus musculus	17-34
32722136-4	2020	The potential as alpha-glucosidase inhibitors of products was evaluated with oral sucrose and lactose tolerance (OSTT and OLTT, respectively) and intestinal sucrose hydrolysis (ISH) tests; the potential as SGLT-1 inhibitors was evaluated using oral glucose tolerance (OGTT), intestinal glucose absorption (IGA), and urinary glucose excretion (UGE) tests.	Glucose	249-256	sucrase isomaltase (alpha-glucosidase)	Mus musculus	17-34
32034442-0	2020	The glucose-lowering effects of alpha-glucosidase inhibitor require a bile acid signal in mice.	Bile Acids and Salts	70-79	sucrase isomaltase (alpha-glucosidase)	Mus musculus	32-49
32034442-1	2020	AIMS/HYPOTHESIS: Bile-acid (BA) signalling is crucial in metabolism homeostasis and has recently been found to mediate the therapeutic effects of glucose-lowering treatments, including alpha-glucosidase inhibitor (AGI).	Bile Acids and Salts	28-30	sucrase isomaltase (alpha-glucosidase)	Mus musculus	185-202
32034442-1	2020	AIMS/HYPOTHESIS: Bile-acid (BA) signalling is crucial in metabolism homeostasis and has recently been found to mediate the therapeutic effects of glucose-lowering treatments, including alpha-glucosidase inhibitor (AGI).	Glucose	146-153	sucrase isomaltase (alpha-glucosidase)	Mus musculus	185-202
32091240-0	2021	Hexane fraction from Brazilian Morus nigra leaves improved oral carbohydrate tolerance and inhibits alpha-amylase and alpha-glucosidase activities in diabetic mice.	Hexanes	0-6	sucrase isomaltase (alpha-glucosidase)	Mus musculus	118-135
32368636-4	2020	alpha-Glucosidase inhibitory bioassay-guided isolation of the ethyl acetate extract of the leaves of G.cowa resulted in the isolation and identification of 11 compounds.	ethyl acetate	62-75	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
32210144-0	2020	Alpha-Glucosidase Inhibitor Voglibose Suppresses Azoxymethane-Induced Colonic Preneoplastic Lesions in Diabetic and Obese Mice.	voglibose	28-37	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
32210144-0	2020	Alpha-Glucosidase Inhibitor Voglibose Suppresses Azoxymethane-Induced Colonic Preneoplastic Lesions in Diabetic and Obese Mice.	Azoxymethane	49-61	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
32210144-3	2020	This study aimed to investigate the preventive effects of the alpha-glucosidase inhibitor voglibose on the development of azoxymethane-induced colorectal pre-neoplastic lesions in obese and diabetic C57BL/KsJ-db/db mice.	voglibose	90-99	sucrase isomaltase (alpha-glucosidase)	Mus musculus	62-79
32116723-6	2020	The ethyl acetate extract significantly inhibited alpha-glucosidase activity, and the inhibition potency was equivalent to that of acarbose (p > 0.05).	ethyl acetate	4-17	sucrase isomaltase (alpha-glucosidase)	Mus musculus	50-67
32116723-8	2020	As the n-butanol and ethyl acetate extracts were found to have potent anti-inflammatory and alpha-glucosidase-inhibitory activities, we separated and identified 10 compounds from the extracts.	1-Butanol	7-16	sucrase isomaltase (alpha-glucosidase)	Mus musculus	92-109
32116723-8	2020	As the n-butanol and ethyl acetate extracts were found to have potent anti-inflammatory and alpha-glucosidase-inhibitory activities, we separated and identified 10 compounds from the extracts.	ethyl acetate	21-34	sucrase isomaltase (alpha-glucosidase)	Mus musculus	92-109
31650545-3	2020	This study aimed to explore the inhibitory effect and interaction mechanism of ursolic acid against alpha-amylase and alpha-glucosidase.	ursolic acid	79-91	sucrase isomaltase (alpha-glucosidase)	Mus musculus	118-135
31650545-6	2020	The results of enzymatic kinetics showed that ursolic acid inhibited alpha-amylase and alpha-glucosidase activity in a noncompetitive manner.	ursolic acid	46-58	sucrase isomaltase (alpha-glucosidase)	Mus musculus	87-104
31650545-9	2020	Molecular docking results showed that ursolic acid bound to the inactive site of alpha-amylase and alpha-glucosidase through the formation of ursolic acid-glucosidase complex.	ursolic acid	38-50	sucrase isomaltase (alpha-glucosidase)	Mus musculus	99-116
32116681-13	2019	Miglitol, another alpha-glucosidase inhibitor showed a similar but less potent anti-arthritic effect to that of acarbose.	miglitol	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	18-35
31650545-5	2020	The half-maximal inhibitory concentration (IC50 ) of ursolic acid on alpha-amylase and alpha-glucosidase was (0.482 +- 0.12) mg mL-1 and (0.213 +- 0.042) mg mL-1 , respectively.	ursolic acid	53-65	sucrase isomaltase (alpha-glucosidase)	Mus musculus	87-104
31650545-9	2020	Molecular docking results showed that ursolic acid bound to the inactive site of alpha-amylase and alpha-glucosidase through the formation of ursolic acid-glucosidase complex.	ursolic acid	142-154	sucrase isomaltase (alpha-glucosidase)	Mus musculus	99-116
31650545-10	2020	Ursolic acid interacted with alpha-amylase and alpha-glucosidase mainly through hydrogen bonding.	ursolic acid	0-12	sucrase isomaltase (alpha-glucosidase)	Mus musculus	47-64
31102272-7	2019	Further, the percentage of alpha-glucosidase and alpha-amylase inhibition rate of TPA-loaded NE was found to be 78.5 and 43.42%, respectively.	Tetradecanoylphorbol Acetate	82-85	sucrase isomaltase (alpha-glucosidase)	Mus musculus	27-44
31650545-10	2020	Ursolic acid interacted with alpha-amylase and alpha-glucosidase mainly through hydrogen bonding.	Hydrogen	80-88	sucrase isomaltase (alpha-glucosidase)	Mus musculus	47-64
32013271-5	2020	The ethanol and aqueous extracts showed a significant alpha-glucosidase inhibitory activity, which was more effective than acarbose at the same concentration.	Ethanol	4-11	sucrase isomaltase (alpha-glucosidase)	Mus musculus	54-71
32013271-5	2020	The ethanol and aqueous extracts showed a significant alpha-glucosidase inhibitory activity, which was more effective than acarbose at the same concentration.	Acarbose	123-131	sucrase isomaltase (alpha-glucosidase)	Mus musculus	54-71
32013271-7	2020	Isoscutellarein-8-O-beta-D-glucopyranoside (IG) was identified from the ethanol extract, which showed a strong inhibitory activity against alpha-glucosidase, with a ten times higher potency compared with the positive control acarbose.	isoscutellarein 5-O-beta-glucopyranoside	0-42	sucrase isomaltase (alpha-glucosidase)	Mus musculus	139-156
32013271-7	2020	Isoscutellarein-8-O-beta-D-glucopyranoside (IG) was identified from the ethanol extract, which showed a strong inhibitory activity against alpha-glucosidase, with a ten times higher potency compared with the positive control acarbose.	isoscutellarein 5-O-beta-glucopyranoside	44-46	sucrase isomaltase (alpha-glucosidase)	Mus musculus	139-156
32013271-7	2020	Isoscutellarein-8-O-beta-D-glucopyranoside (IG) was identified from the ethanol extract, which showed a strong inhibitory activity against alpha-glucosidase, with a ten times higher potency compared with the positive control acarbose.	Ethanol	72-79	sucrase isomaltase (alpha-glucosidase)	Mus musculus	139-156
32812937-0	2020	The alpha-glucosidase inhibitor miglitol increases hepatic CYP7A1 activity in association with altered short-chain fatty acid production in the gut of obese diabetic mice.	miglitol	32-40	sucrase isomaltase (alpha-glucosidase)	Mus musculus	4-21
32812937-0	2020	The alpha-glucosidase inhibitor miglitol increases hepatic CYP7A1 activity in association with altered short-chain fatty acid production in the gut of obese diabetic mice.	Fatty Acids, Volatile	103-125	sucrase isomaltase (alpha-glucosidase)	Mus musculus	4-21
32812937-2	2020	We have recently reported that miglitol, an alpha-glucosidase inhibitor, increases fecal BA excretion and ameliorate insulin resistance and obesity in mice.	miglitol	31-39	sucrase isomaltase (alpha-glucosidase)	Mus musculus	44-61
32812937-2	2020	We have recently reported that miglitol, an alpha-glucosidase inhibitor, increases fecal BA excretion and ameliorate insulin resistance and obesity in mice.	Bile Acids and Salts	89-91	sucrase isomaltase (alpha-glucosidase)	Mus musculus	44-61
32003674-0	2020	Tyramine Derivatives as Potent Therapeutics for Type 2 Diabetes: Synthesis and In Vitro Inhibition of alpha-Glucosidase Enzyme.	Tyramine	0-8	sucrase isomaltase (alpha-glucosidase)	Mus musculus	102-119
32003674-1	2020	BACKGROUND: Tyramine derivatives 3-16 were prepared and tested first time for their alpha-glucosidase (Sources: Saccharomyces cerevisiae) inhibitory activity by using an in vitro mechanism-based biochemical assay.	Tyramine	12-20	sucrase isomaltase (alpha-glucosidase)	Mus musculus	84-101
31926084-8	2020	All the extracts showed high phenolic and flavonoid contents, which correlated with their antioxidant, anticholinesterase, alpha-glucosidase and alpha-amylase activities.	Flavonoids	42-51	sucrase isomaltase (alpha-glucosidase)	Mus musculus	123-140
31609067-5	2019	In vitro study, the ethyl acetate extract (EAE) and butanol extract (BE) of CTC exhibited anti-lipid peroxidation (IC50 : BHA>BE or EAE>ascorbic acid, p<0.05) and alpha-glucosidase inhibitory activity (IC50 : BE>EAE, p<0.05).	ethyl acetate	20-33	sucrase isomaltase (alpha-glucosidase)	Mus musculus	163-180
31609067-5	2019	In vitro study, the ethyl acetate extract (EAE) and butanol extract (BE) of CTC exhibited anti-lipid peroxidation (IC50 : BHA>BE or EAE>ascorbic acid, p<0.05) and alpha-glucosidase inhibitory activity (IC50 : BE>EAE, p<0.05).	EAE	43-46	sucrase isomaltase (alpha-glucosidase)	Mus musculus	163-180
31609067-5	2019	In vitro study, the ethyl acetate extract (EAE) and butanol extract (BE) of CTC exhibited anti-lipid peroxidation (IC50 : BHA>BE or EAE>ascorbic acid, p<0.05) and alpha-glucosidase inhibitory activity (IC50 : BE>EAE, p<0.05).	Butanols	52-59	sucrase isomaltase (alpha-glucosidase)	Mus musculus	163-180
31609067-5	2019	In vitro study, the ethyl acetate extract (EAE) and butanol extract (BE) of CTC exhibited anti-lipid peroxidation (IC50 : BHA>BE or EAE>ascorbic acid, p<0.05) and alpha-glucosidase inhibitory activity (IC50 : BE>EAE, p<0.05).	Beryllium	69-71	sucrase isomaltase (alpha-glucosidase)	Mus musculus	163-180
31369977-2	2019	In current study, we synthesized pyrrolidine-2,5-dione (succinimide) and thiazolidine-2,4-dione derivatives and evaluated for their ability to inhibit alpha-Glucosidase.	succinimide	56-67	sucrase isomaltase (alpha-glucosidase)	Mus musculus	151-168
31450982-0	2019	Butyrolactone-I, an efficient alpha-glucosidase inhibitor, improves type 2 diabetes with potent TNF-alpha-lowering properties through modulating gut microbiota in db/db mice.	butyrolactone I	0-15	sucrase isomaltase (alpha-glucosidase)	Mus musculus	30-47
31450982-3	2019	In this study, 11 butenolide derivatives were screened for their alpha-glucosidase and TNF-alpha suppressive activity in vitro.	butenolide	18-28	sucrase isomaltase (alpha-glucosidase)	Mus musculus	65-82
31072245-0	2019	Benzonate derivatives of acetophenone as potent alpha-glucosidase inhibitors: synthesis, structure-activity relationship and mechanism.	benzonate	0-9	sucrase isomaltase (alpha-glucosidase)	Mus musculus	48-65
31072245-0	2019	Benzonate derivatives of acetophenone as potent alpha-glucosidase inhibitors: synthesis, structure-activity relationship and mechanism.	acetophenone	25-37	sucrase isomaltase (alpha-glucosidase)	Mus musculus	48-65
31889779-7	2019	Ganoderic acid exhibited the inhibitory effect of alpha-glucosidase and alpha-amylase.	ganoderic acid A	0-14	sucrase isomaltase (alpha-glucosidase)	Mus musculus	50-67
31867414-2	2020	Present data demonstrate an in vitro assessment of verticinone effects on beta-TC6 pancreatic and C2C12 skeletal muscle cells include cell survival, activities of carbohydrate-hydrolyzing enzymes (alpha-amylase and alpha-glucosidase), levels of insulin secreted into the media, glucose uptake ability, advanced glycation end product (AGEs) include 3-deoxyglucosone, methylglyoxal, and pentosidine levels and the activity of glyoxalase I.	verticine	51-62	sucrase isomaltase (alpha-glucosidase)	Mus musculus	215-232
31550448-0	2019	5,7-Dimethoxy-3-(2"-hydroxybenzyl)-4-chromanone inhibits alpha-glucosidase in vitro and alleviates postprandial hyperglycemia in diabetic mice.	4-chromanone	0-47	sucrase isomaltase (alpha-glucosidase)	Mus musculus	57-74
31550448-2	2019	5,7-D chromanone strongly inhibited alpha-glucosidase and alpha-amylase (half-maximal inhibitory concentration, IC50; 15.03 +- 2.59 muM and 12.39 +- 2.16 muM, respectively).	4-chromanone	6-16	sucrase isomaltase (alpha-glucosidase)	Mus musculus	36-53
31698833-0	2019	Structure-Activity Relationship Study of Acyclic Terpenes in Blood Glucose Levels: Potential alpha-Glucosidase and Sodium Glucose Cotransporter (SGLT-1) Inhibitors.	Terpenes	49-57	sucrase isomaltase (alpha-glucosidase)	Mus musculus	93-110
31698833-0	2019	Structure-Activity Relationship Study of Acyclic Terpenes in Blood Glucose Levels: Potential alpha-Glucosidase and Sodium Glucose Cotransporter (SGLT-1) Inhibitors.	Glucose	67-74	sucrase isomaltase (alpha-glucosidase)	Mus musculus	93-110
31698833-8	2019	Finally, five acyclic terpenes may be candidates for the development and search for new alpha-glucosidase and SGLT-1 cotransporter inhibitors.	Terpenes	22-30	sucrase isomaltase (alpha-glucosidase)	Mus musculus	88-105
31369977-2	2019	In current study, we synthesized pyrrolidine-2,5-dione (succinimide) and thiazolidine-2,4-dione derivatives and evaluated for their ability to inhibit alpha-Glucosidase.	thiazolidine-2,4-dione	73-95	sucrase isomaltase (alpha-glucosidase)	Mus musculus	151-168
31356939-0	2019	Interaction mechanism of carnosic acid against glycosidase (alpha-amylase and alpha-glucosidase).	salvin	25-38	sucrase isomaltase (alpha-glucosidase)	Mus musculus	78-95
31356939-2	2019	In this study, enzymatic kinetics, fluorescence spectrum experiment, starch granule digestion, molecular docking studies and animal"s studies were used to investigate the interaction mechanism of carnosic acid against two glycosidase (alpha-amylase and alpha-glucosidase).	salvin	196-209	sucrase isomaltase (alpha-glucosidase)	Mus musculus	253-270
31356939-4	2019	The half inhibitory concentrations (IC50) of carnosic acid to alpha-amylase and alpha- glucosidase were (1.12 +- 0.31) and (0.08 +- 0.17), respectively.	salvin	45-58	sucrase isomaltase (alpha-glucosidase)	Mus musculus	80-98
31356939-5	2019	The fluorescence quenching experiments showed that the intrinsic fluorescence of alpha-amylase or alpha-glucosidase was quenched by forming a complex with carnosic acid, and there was only one binding site between carnosic acid and glycosidase.	salvin	155-168	sucrase isomaltase (alpha-glucosidase)	Mus musculus	98-115
31356939-5	2019	The fluorescence quenching experiments showed that the intrinsic fluorescence of alpha-amylase or alpha-glucosidase was quenched by forming a complex with carnosic acid, and there was only one binding site between carnosic acid and glycosidase.	salvin	214-227	sucrase isomaltase (alpha-glucosidase)	Mus musculus	98-115
31509948-5	2019	Despite the robust alteration in the gut microbiome in DIO mice, co-administration of maltose and the alpha-glucosidase inhibitor (alpha-GI) miglitol induced the microbiome-mediated suppression of GIP secretion.	miglitol	141-149	sucrase isomaltase (alpha-glucosidase)	Mus musculus	102-119
31500170-0	2019	Carbon Nanoparticles Inhibit Alpha-Glucosidase Activity and Induce a Hypoglycemic Effect in Diabetic Mice.	Carbon	0-6	sucrase isomaltase (alpha-glucosidase)	Mus musculus	29-46
31500170-6	2019	In vitro, the as-prepared CNPs could inhibit alpha-glucosidase with an IC50 value of 0.5677 mg/mL, which is close to that of the reference drug acarbose.	Acarbose	144-152	sucrase isomaltase (alpha-glucosidase)	Mus musculus	45-62
29683341-0	2019	Betulinic acid derivatives: a new class of alpha-glucosidase inhibitors and LPS-stimulated nitric oxide production inhibition on mouse macrophage RAW 264.7 cells.	betulinic acid	0-14	sucrase isomaltase (alpha-glucosidase)	Mus musculus	43-60