PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33946784-3	2021	DHTKD1 is a gene encoding 2-oxoadipate dehydrogenase (E1a), which functions in the L-lysine degradation pathway.	Lysine	83-91	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	0-6
33674273-8	2021	RESULTS: The comprehensive multi-omics analysis and functional experiment revealed that MRPS5 and GSPT1 had strong effects on cell proliferation, and CD55 and DHTKD1 contributed to gemcitabine resistance in PC cells.	gemcitabine	181-192	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	159-165
32695416-0	2020	Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism.	Lysine	110-116	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	51-57
33511099-13	2020	The consistent kinetic and structural results expose adipoyl phosphonate as a valuable pharmacological tool for specific in vivo inhibition of the DHTKD1-encoded OADH, a new member of mammalian family of 2-oxo acid dehydrogenases, up-regulated in some cancers and associated with diabetes and obesity.	adipoyl phosphonate	53-72	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	147-153
32633484-0	2020	Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex.	flopropione	53-72	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	46-52
32633484-1	2020	DHTKD1 is the E1 component of the 2-oxoadipate dehydrogenase complex, an enzyme involved in the catabolism of (hydroxy-)lysine and tryptophan.	Hydroxylysine	110-126	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	0-6
32633484-1	2020	DHTKD1 is the E1 component of the 2-oxoadipate dehydrogenase complex, an enzyme involved in the catabolism of (hydroxy-)lysine and tryptophan.	Tryptophan	131-141	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	0-6
32633484-3	2020	Here we report the identification of adipoylphosphonic acid and tenatoprazole as DHTKD1 inhibitors using targeted and high throughput screening, respectively.	adipoylphosphonic acid	37-59	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	81-87
32633484-3	2020	Here we report the identification of adipoylphosphonic acid and tenatoprazole as DHTKD1 inhibitors using targeted and high throughput screening, respectively.	Tenatoprazole	64-77	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	81-87
32633484-4	2020	We furthermore elucidate the DHTKD1 crystal structure with thiamin diphosphate bound at 2.25 A.	flopropione	59-78	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	29-35
32695416-2	2020	In complex with E2 (di-hydro-lipo-amide succinyltransferase, DLST) and E3 (dihydrolipo-amide de-hydrogenase, DLD) components, DHTKD1 is involved in lysine and tryptophan catabolism by catalysing the oxidative de-carboxyl-ation of 2-oxoadipate (2OA) in mitochondria.	Lysine	148-154	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	126-132
32695416-2	2020	In complex with E2 (di-hydro-lipo-amide succinyltransferase, DLST) and E3 (dihydrolipo-amide de-hydrogenase, DLD) components, DHTKD1 is involved in lysine and tryptophan catabolism by catalysing the oxidative de-carboxyl-ation of 2-oxoadipate (2OA) in mitochondria.	Tryptophan	159-169	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	126-132
32695416-2	2020	In complex with E2 (di-hydro-lipo-amide succinyltransferase, DLST) and E3 (dihydrolipo-amide de-hydrogenase, DLD) components, DHTKD1 is involved in lysine and tryptophan catabolism by catalysing the oxidative de-carboxyl-ation of 2-oxoadipate (2OA) in mitochondria.	alpha-ketoadipic acid	230-242	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	126-132
32695416-2	2020	In complex with E2 (di-hydro-lipo-amide succinyltransferase, DLST) and E3 (dihydrolipo-amide de-hydrogenase, DLD) components, DHTKD1 is involved in lysine and tryptophan catabolism by catalysing the oxidative de-carboxyl-ation of 2-oxoadipate (2OA) in mitochondria.	2oa	244-247	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	126-132
32695416-3	2020	Here, the 1.9 A resolution crystal structure of human DHTKD1 is solved in complex with the thi-amine diphosphate co-factor.	Thiamine Pyrophosphate	91-112	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	54-60
32695416-4	2020	The structure reveals how the DHTKD1 active site is modelled upon the well characterized homologue 2-oxoglutarate (2OG) de-hydrogenase but engineered specifically to accommodate its preference for the longer substrate of 2OA over 2OG.	Ketoglutaric Acids	99-113	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	30-36
32303640-1	2020	2-Oxoadipate dehydrogenase (E1a, also known as DHTKD1, dehydrogenase E1, and transketolase domain-containing protein 1) is a thiamin diphosphate-dependent enzyme and part of the 2-oxoadipate dehydrogenase complex (OADHc) in l-lysine catabolism.	flopropione	125-144	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	47-53
32303640-1	2020	2-Oxoadipate dehydrogenase (E1a, also known as DHTKD1, dehydrogenase E1, and transketolase domain-containing protein 1) is a thiamin diphosphate-dependent enzyme and part of the 2-oxoadipate dehydrogenase complex (OADHc) in l-lysine catabolism.	flopropione	125-144	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	55-118
32303640-1	2020	2-Oxoadipate dehydrogenase (E1a, also known as DHTKD1, dehydrogenase E1, and transketolase domain-containing protein 1) is a thiamin diphosphate-dependent enzyme and part of the 2-oxoadipate dehydrogenase complex (OADHc) in l-lysine catabolism.	Lysine	224-232	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	47-53
32303640-1	2020	2-Oxoadipate dehydrogenase (E1a, also known as DHTKD1, dehydrogenase E1, and transketolase domain-containing protein 1) is a thiamin diphosphate-dependent enzyme and part of the 2-oxoadipate dehydrogenase complex (OADHc) in l-lysine catabolism.	Lysine	224-232	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	55-118
32303640-7	2020	A multipronged systematic analysis of the reaction rates in the OADHc pathway, supplemented with results from chemical cross-linking and hydrogen-deuterium exchange MS, revealed that the c.2185G A DHTKD1 mutation affects E1a-E2o assembly, leading to impaired channeling of OADHc intermediates.	Hydrogen	137-145	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	197-203
32303640-7	2020	A multipronged systematic analysis of the reaction rates in the OADHc pathway, supplemented with results from chemical cross-linking and hydrogen-deuterium exchange MS, revealed that the c.2185G A DHTKD1 mutation affects E1a-E2o assembly, leading to impaired channeling of OADHc intermediates.	Deuterium	146-155	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	197-203
32303640-7	2020	A multipronged systematic analysis of the reaction rates in the OADHc pathway, supplemented with results from chemical cross-linking and hydrogen-deuterium exchange MS, revealed that the c.2185G A DHTKD1 mutation affects E1a-E2o assembly, leading to impaired channeling of OADHc intermediates.	7-chloranyl-5-[3-[(3~{S})-piperidin-3-yl]propyl]pyrido[3,4-b][1,4]benzoxazine	225-228	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	197-203
32160276-3	2020	Here we show that loss of DHTKD1 in GCDH-deficient HEK-293 cells leads to a 2-fold decrease in the established GA1 clinical biomarker glutarylcarnitine, and demonstrate that OGDH is responsible for this remaining glutarylcarnitine production.	glutarylcarnitine	134-151	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	26-32
32160276-3	2020	Here we show that loss of DHTKD1 in GCDH-deficient HEK-293 cells leads to a 2-fold decrease in the established GA1 clinical biomarker glutarylcarnitine, and demonstrate that OGDH is responsible for this remaining glutarylcarnitine production.	glutarylcarnitine	213-230	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	26-32
32160276-5	2020	In summary, 2-oxoadipic acid is a substrate for DHTKD1, but also for OGDH in a cell model system.	alpha-ketoadipic acid	12-28	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	48-54
32160276-6	2020	The classical 2-oxoglutaric dehydrogenase complex can exist as a previously undiscovered hybrid containing DHTKD1 displaying improved kinetics towards 2-oxoadipic acid.	alpha-ketoadipic acid	151-167	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	107-113
29669943-7	2018	Finally, we demonstrated that the loss of DHTKD1 expression increased ROS production and induced the expression of viperin, a gene previously shown to be involved in production of Th2 cytokines in T cells.	ros	70-73	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	42-48
32024885-4	2020	Using succinyl, glutaryl and adipoyl phosphonates on the enzyme preparations from tissues with varied DHTKD1 expression reveals the contributions of OADH and OGDH to oxidation of 2-oxoadipate and 2-oxoglutarate in vitro.	Aligeron	179-191	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	102-108
32024885-4	2020	Using succinyl, glutaryl and adipoyl phosphonates on the enzyme preparations from tissues with varied DHTKD1 expression reveals the contributions of OADH and OGDH to oxidation of 2-oxoadipate and 2-oxoglutarate in vitro.	2-oxoglutarate	196-210	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	102-108
32024885-5	2020	In the phosphonates-treated cells with the high and low DHTKD1 expression, adipate or glutarate, correspondingly, are the most affected metabolites.	Organophosphonates	7-19	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	56-62
32024885-5	2020	In the phosphonates-treated cells with the high and low DHTKD1 expression, adipate or glutarate, correspondingly, are the most affected metabolites.	Glutarates	86-95	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	56-62
32024885-1	2020	The biological significance of the DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) remains obscure due to its catalytic redundancy with the ubiquitous OGDH-encoded 2-oxoglutarate dehydrogenase (OGDH).	Aligeron	50-62	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	35-41
32024885-2	2020	In this work, metabolic contributions of OADH and OGDH are discriminated by exposure of cells/tissues with different DHTKD1 expression to the synthesized phosphonate analogues of homologous 2-oxodicarboxylates.	Organophosphonates	154-165	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	117-123
32024885-2	2020	In this work, metabolic contributions of OADH and OGDH are discriminated by exposure of cells/tissues with different DHTKD1 expression to the synthesized phosphonate analogues of homologous 2-oxodicarboxylates.	Aligeron	190-209	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	117-123
32024885-3	2020	The saccharopine pathway intermediates and phosphorylated sugars are abundant when cellular expressions of DHTKD1 and OGDH are comparable, while nicotinate and non-phosphorylated sugars are when DHTKD1 expression is order(s) of magnitude lower than that of OGDH.	Carbohydrates	58-64	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	107-113
32024885-3	2020	The saccharopine pathway intermediates and phosphorylated sugars are abundant when cellular expressions of DHTKD1 and OGDH are comparable, while nicotinate and non-phosphorylated sugars are when DHTKD1 expression is order(s) of magnitude lower than that of OGDH.	Niacin	145-155	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	195-201
32024885-3	2020	The saccharopine pathway intermediates and phosphorylated sugars are abundant when cellular expressions of DHTKD1 and OGDH are comparable, while nicotinate and non-phosphorylated sugars are when DHTKD1 expression is order(s) of magnitude lower than that of OGDH.	Carbohydrates	179-185	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	195-201
32024885-4	2020	Using succinyl, glutaryl and adipoyl phosphonates on the enzyme preparations from tissues with varied DHTKD1 expression reveals the contributions of OADH and OGDH to oxidation of 2-oxoadipate and 2-oxoglutarate in vitro.	succinyl phosphate	6-14	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	102-108
32024885-4	2020	Using succinyl, glutaryl and adipoyl phosphonates on the enzyme preparations from tissues with varied DHTKD1 expression reveals the contributions of OADH and OGDH to oxidation of 2-oxoadipate and 2-oxoglutarate in vitro.	glutaryl-coenzyme A	16-24	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	102-108
32024885-4	2020	Using succinyl, glutaryl and adipoyl phosphonates on the enzyme preparations from tissues with varied DHTKD1 expression reveals the contributions of OADH and OGDH to oxidation of 2-oxoadipate and 2-oxoglutarate in vitro.	adipoyl chloride	29-49	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	102-108
29191460-1	2018	Herein are reported unique properties of the novel human thiamin diphosphate (ThDP)-dependent enzyme 2-oxoadipate dehydrogenase (hE1a), known as dehydrogenase E1 and transketolase domain-containing protein 1 that is encoded by the DHTKD1 gene.	Thiamine Pyrophosphate	57-76	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	145-207
29191460-1	2018	Herein are reported unique properties of the novel human thiamin diphosphate (ThDP)-dependent enzyme 2-oxoadipate dehydrogenase (hE1a), known as dehydrogenase E1 and transketolase domain-containing protein 1 that is encoded by the DHTKD1 gene.	Thiamine Pyrophosphate	57-76	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	231-237
29191460-1	2018	Herein are reported unique properties of the novel human thiamin diphosphate (ThDP)-dependent enzyme 2-oxoadipate dehydrogenase (hE1a), known as dehydrogenase E1 and transketolase domain-containing protein 1 that is encoded by the DHTKD1 gene.	Thiamine Pyrophosphate	78-82	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	145-207
29191460-1	2018	Herein are reported unique properties of the novel human thiamin diphosphate (ThDP)-dependent enzyme 2-oxoadipate dehydrogenase (hE1a), known as dehydrogenase E1 and transketolase domain-containing protein 1 that is encoded by the DHTKD1 gene.	Thiamine Pyrophosphate	78-82	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	231-237
24076469-5	2013	Here, we report a strong correlation of DHTKD1 expression level with ATP production, revealing the fact that DHTKD1 plays a critical role in energy production in mitochondria.	Adenosine Triphosphate	69-72	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	40-46
26708453-1	2016	In humans, mutations in dehydrogenase E1 and transketolase domain containing 1 (DHTKD1) are associated with neurological abnormalities and accumulation of 2-oxoadipate, 2-aminoadipate, and reactive oxygen species.	alpha-ketoadipic acid	155-167	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	80-86
26708453-1	2016	In humans, mutations in dehydrogenase E1 and transketolase domain containing 1 (DHTKD1) are associated with neurological abnormalities and accumulation of 2-oxoadipate, 2-aminoadipate, and reactive oxygen species.	2-Aminoadipic Acid	169-183	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	80-86
26708453-1	2016	In humans, mutations in dehydrogenase E1 and transketolase domain containing 1 (DHTKD1) are associated with neurological abnormalities and accumulation of 2-oxoadipate, 2-aminoadipate, and reactive oxygen species.	Reactive Oxygen Species	189-212	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	80-86
26708453-2	2016	The protein encoded by DHTKD1 has sequence and structural similarities to 2-oxoglutarate dehydrogenase, and the 2-oxoglutarate dehydrogenase complex can produce superoxide/H2O2 at high rates.	Superoxides	161-171	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	23-29
26708453-2	2016	The protein encoded by DHTKD1 has sequence and structural similarities to 2-oxoglutarate dehydrogenase, and the 2-oxoglutarate dehydrogenase complex can produce superoxide/H2O2 at high rates.	Hydrogen Peroxide	172-176	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	23-29
26708453-3	2016	The DHTKD1 enzyme is hypothesized to catalyze the oxidative decarboxylation of 2-oxoadipate, a shared intermediate of the degradative pathways for tryptophan, lysine and hydroxylysine.	alpha-ketoadipic acid	79-91	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	4-10
26708453-3	2016	The DHTKD1 enzyme is hypothesized to catalyze the oxidative decarboxylation of 2-oxoadipate, a shared intermediate of the degradative pathways for tryptophan, lysine and hydroxylysine.	Tryptophan	147-157	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	4-10
26708453-3	2016	The DHTKD1 enzyme is hypothesized to catalyze the oxidative decarboxylation of 2-oxoadipate, a shared intermediate of the degradative pathways for tryptophan, lysine and hydroxylysine.	Lysine	159-165	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	4-10
26708453-3	2016	The DHTKD1 enzyme is hypothesized to catalyze the oxidative decarboxylation of 2-oxoadipate, a shared intermediate of the degradative pathways for tryptophan, lysine and hydroxylysine.	Hydroxylysine	170-183	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	4-10
24076469-5	2013	Here, we report a strong correlation of DHTKD1 expression level with ATP production, revealing the fact that DHTKD1 plays a critical role in energy production in mitochondria.	Adenosine Triphosphate	69-72	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	109-115
24076469-6	2013	Moreover, suppression of DHTKD1 leads to impaired mitochondrial biogenesis and increased reactive oxygen species (ROS), thus leading to retarded cell growth and increased cell apoptosis.	Reactive Oxygen Species	89-112	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	25-31
24076469-6	2013	Moreover, suppression of DHTKD1 leads to impaired mitochondrial biogenesis and increased reactive oxygen species (ROS), thus leading to retarded cell growth and increased cell apoptosis.	Reactive Oxygen Species	114-117	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	25-31
23141293-9	2012	Increased levels of 2-oxoadipate in individual-derived fibroblasts normalized upon lentiviral expression of the wild-type DHTKD1 mRNA.	alpha-ketoadipic acid	20-32	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	122-128
23141293-10	2012	Moreover, investigation of L-lysine metabolism showed an accumulation of deuterium-labeled 2-oxoadipate only in noncomplemented cells, demonstrating that DHTKD1 codes for the enzyme mediating the last unresolved step in the L-lysine-degradation pathway.	Lysine	27-35	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	154-160
23141293-10	2012	Moreover, investigation of L-lysine metabolism showed an accumulation of deuterium-labeled 2-oxoadipate only in noncomplemented cells, demonstrating that DHTKD1 codes for the enzyme mediating the last unresolved step in the L-lysine-degradation pathway.	Deuterium	73-82	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	154-160
23141293-10	2012	Moreover, investigation of L-lysine metabolism showed an accumulation of deuterium-labeled 2-oxoadipate only in noncomplemented cells, demonstrating that DHTKD1 codes for the enzyme mediating the last unresolved step in the L-lysine-degradation pathway.	alpha-ketoadipic acid	91-103	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	154-160
23141293-10	2012	Moreover, investigation of L-lysine metabolism showed an accumulation of deuterium-labeled 2-oxoadipate only in noncomplemented cells, demonstrating that DHTKD1 codes for the enzyme mediating the last unresolved step in the L-lysine-degradation pathway.	Lysine	224-232	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	154-160
23141293-11	2012	All together, our results establish mutations in DHTKD1 as a cause of human 2-aminoadipic and 2-oxoadipic aciduria via impaired turnover of decarboxylation 2-oxoadipate to glutaryl-CoA.	alpha-ketoadipic acid	156-168	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	49-55
23141293-11	2012	All together, our results establish mutations in DHTKD1 as a cause of human 2-aminoadipic and 2-oxoadipic aciduria via impaired turnover of decarboxylation 2-oxoadipate to glutaryl-CoA.	glutaryl-coenzyme A	172-184	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	49-55
23141294-8	2012	More importantly, DHTKD1 silencing was found to lead to impaired energy production, evidenced by decreased ATP, total NAD(+) and NADH, and NADH levels.	Adenosine Triphosphate	107-110	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	18-24
23141294-8	2012	More importantly, DHTKD1 silencing was found to lead to impaired energy production, evidenced by decreased ATP, total NAD(+) and NADH, and NADH levels.	NAD	118-124	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	18-24
23141294-8	2012	More importantly, DHTKD1 silencing was found to lead to impaired energy production, evidenced by decreased ATP, total NAD(+) and NADH, and NADH levels.	NAD	129-133	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	18-24
23141294-8	2012	More importantly, DHTKD1 silencing was found to lead to impaired energy production, evidenced by decreased ATP, total NAD(+) and NADH, and NADH levels.	NAD	139-143	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	18-24