PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
11684026-4	2001	Osmotin treatment resulted in suppression of transcription of stress-responsive genes via the RAS2/cAMP pathway.	Cyclic AMP	99-103	osmotin	Nicotiana tabacum	0-7
12297654-1	1992	By introducing a chimeric gene fusion of the osmotin promoter and [beta]-glucuronidase into tobacco by Agrobacterium-mediated transformation, we have demonstrated a very specific pattern of temporal and spatial regulation of the osmotin promoter during normal plant development and after adaptation to NaCl.	Sodium Chloride	302-306	osmotin	Nicotiana tabacum	45-52
10719625-4	1999	One mutant, delta C18 osmotin, had a nonsense mutation near the C-terminus that deleted the carboxyl terminal prepropeptide (CTPP) of 18 amino acids.	prepropeptide	110-123	osmotin	Nicotiana tabacum	22-29
10719625-4	1999	One mutant, delta C18 osmotin, had a nonsense mutation near the C-terminus that deleted the carboxyl terminal prepropeptide (CTPP) of 18 amino acids.	ctpp	125-129	osmotin	Nicotiana tabacum	22-29
8448358-3	1993	Amino acid sequencing of the purified protein showed that AP24 is synthesized as a preproprotein from which an amino-terminal signal peptide and a carboxyl-terminal propeptide (CTPP) are cleaved off during post-translational processing.	propeptide	165-175	osmotin	Nicotiana tabacum	58-62
8448358-3	1993	Amino acid sequencing of the purified protein showed that AP24 is synthesized as a preproprotein from which an amino-terminal signal peptide and a carboxyl-terminal propeptide (CTPP) are cleaved off during post-translational processing.	ctpp	177-181	osmotin	Nicotiana tabacum	58-62
8448358-6	1993	In contrast, the proteins produced in plants expressing the mutant construct were secreted extracellularly, indicating that the CTPP is necessary for targeting of AP24 to the vacuoles.	ctpp	128-132	osmotin	Nicotiana tabacum	163-167
9225851-0	1997	Tissue-specific activation of the osmotin gene by ABA, C2H4 and NaCl involves the same promoter region.	Abscisic Acid	50-53	osmotin	Nicotiana tabacum	34-41
9225851-0	1997	Tissue-specific activation of the osmotin gene by ABA, C2H4 and NaCl involves the same promoter region.	ethylene	55-59	osmotin	Nicotiana tabacum	34-41
9225851-0	1997	Tissue-specific activation of the osmotin gene by ABA, C2H4 and NaCl involves the same promoter region.	Sodium Chloride	64-68	osmotin	Nicotiana tabacum	34-41
16652977-5	1992	Accumulation of osmotin mRNA but not protein occurred in some plant tissues due to treatment with abscisic acid, wounding, and tobacco mosaic virus infection.	Abscisic Acid	98-111	osmotin	Nicotiana tabacum	16-23
16652977-6	1992	Ethylene induced the accumulation of osmotin mRNA and, to a small extent, protein in seedlings, but was ineffective with cultured cells.	ethylene	0-8	osmotin	Nicotiana tabacum	37-44
12297654-1	1992	By introducing a chimeric gene fusion of the osmotin promoter and [beta]-glucuronidase into tobacco by Agrobacterium-mediated transformation, we have demonstrated a very specific pattern of temporal and spatial regulation of the osmotin promoter during normal plant development and after adaptation to NaCl.	Sodium Chloride	302-306	osmotin	Nicotiana tabacum	229-236
12297654-6	1992	Adaptation of plants to NaCl highly stimulated osmotin promoter activity in epidermal and cortex parenchyma cells in the root elongation zone; in epidermis and xylem parenchyma cells in stem internodes; and in epidermis, mesophyll, and xylem parenchyma cells in developed leaves.	Sodium Chloride	24-28	osmotin	Nicotiana tabacum	47-54
12297654-6	1992	Adaptation of plants to NaCl highly stimulated osmotin promoter activity in epidermal and cortex parenchyma cells in the root elongation zone; in epidermis and xylem parenchyma cells in stem internodes; and in epidermis, mesophyll, and xylem parenchyma cells in developed leaves.	mesophyll	221-230	osmotin	Nicotiana tabacum	47-54
2152343-4	1990	Another sequence family encodes the water stress-induced protein osmotin [Singh et al.	Water	36-41	osmotin	Nicotiana tabacum	65-72
1385735-3	1992	In cell suspension cultures of tobacco, the osmotin gene was shown to be transcriptionally activated by treatment with ABA.	alisol B 23-acetate	119-122	osmotin	Nicotiana tabacum	44-51
1385735-5	1992	In these plants, the osmotin promoter is transcriptionally activated by the hormones ABA and ethylene.	alisol B 23-acetate	85-88	osmotin	Nicotiana tabacum	21-28
1385735-5	1992	In these plants, the osmotin promoter is transcriptionally activated by the hormones ABA and ethylene.	ethylene	93-101	osmotin	Nicotiana tabacum	21-28
1385735-6	1992	The sensitivity of the osmotin promoter to ABA applied exogenously decreased with age in both roots and shoots of young seedlings.	alisol B 23-acetate	43-46	osmotin	Nicotiana tabacum	23-30
28811634-2	2017	The therapeutic properties of osmotin have been explored in recent years as it exhibits neuroprotective effects against amyloid beta-, glutamate- and ethanol-induced synaptic dysfunction and neurodegeneration.	Glutamic Acid	135-144	osmotin	Nicotiana tabacum	30-37
32759884-6	2020	Therefore, overexpression of tobacco osmotin protein in transgenic plants protects them from different stresses by reducing reactive oxygen species (ROS) production, limiting lipid peroxidation, initiating programmed cell death (PCD), and increasing proline content and scavenging enzyme activity.	Reactive Oxygen Species	124-147	osmotin	Nicotiana tabacum	37-44
32759884-6	2020	Therefore, overexpression of tobacco osmotin protein in transgenic plants protects them from different stresses by reducing reactive oxygen species (ROS) production, limiting lipid peroxidation, initiating programmed cell death (PCD), and increasing proline content and scavenging enzyme activity.	Reactive Oxygen Species	149-152	osmotin	Nicotiana tabacum	37-44
32759884-6	2020	Therefore, overexpression of tobacco osmotin protein in transgenic plants protects them from different stresses by reducing reactive oxygen species (ROS) production, limiting lipid peroxidation, initiating programmed cell death (PCD), and increasing proline content and scavenging enzyme activity.	Proline	250-257	osmotin	Nicotiana tabacum	37-44
16667148-0	1989	Stable NaCl Tolerance of Tobacco Cells Is Associated with Enhanced Accumulation of Osmotin.	Sodium Chloride	7-11	osmotin	Nicotiana tabacum	83-90
16667148-2	1989	Quantitation of osmotin levels by immunoblots indicated that cells adapted to 428 millimolar NaCl contained 4 to 30 times the level of osmotin found in unadapted cells, depending on the stage of growth.	Sodium Chloride	93-97	osmotin	Nicotiana tabacum	16-23
16667148-2	1989	Quantitation of osmotin levels by immunoblots indicated that cells adapted to 428 millimolar NaCl contained 4 to 30 times the level of osmotin found in unadapted cells, depending on the stage of growth.	Sodium Chloride	93-97	osmotin	Nicotiana tabacum	135-142
16667148-4	1989	Upon transfer of NaCl-adapted cells to medium without NaCl and subsequent growth for many cell generations, the amount of osmotin declined gradually to a level intermediate between that found in adapted and unadapted cells.	Sodium Chloride	17-21	osmotin	Nicotiana tabacum	122-129
16667148-4	1989	Upon transfer of NaCl-adapted cells to medium without NaCl and subsequent growth for many cell generations, the amount of osmotin declined gradually to a level intermediate between that found in adapted and unadapted cells.	Sodium Chloride	54-58	osmotin	Nicotiana tabacum	122-129
16667148-7	1989	The association between osmotin accumulation and stable NaCl tolerance indicates that cells with a stable genetic change affecting the accumulation of osmotin are selected during prolonged exposure to high levels of NaCl.	Sodium Chloride	56-60	osmotin	Nicotiana tabacum	24-31
16667148-7	1989	The association between osmotin accumulation and stable NaCl tolerance indicates that cells with a stable genetic change affecting the accumulation of osmotin are selected during prolonged exposure to high levels of NaCl.	Sodium Chloride	56-60	osmotin	Nicotiana tabacum	151-158
16667148-7	1989	The association between osmotin accumulation and stable NaCl tolerance indicates that cells with a stable genetic change affecting the accumulation of osmotin are selected during prolonged exposure to high levels of NaCl.	Sodium Chloride	216-220	osmotin	Nicotiana tabacum	24-31
16667148-7	1989	The association between osmotin accumulation and stable NaCl tolerance indicates that cells with a stable genetic change affecting the accumulation of osmotin are selected during prolonged exposure to high levels of NaCl.	Sodium Chloride	216-220	osmotin	Nicotiana tabacum	151-158
16666857-0	1989	Molecular Cloning of Osmotin and Regulation of Its Expression by ABA and Adaptation to Low Water Potential.	Abscisic Acid	65-68	osmotin	Nicotiana tabacum	21-28
16666857-1	1989	In response to adaptation to NaCl, cultured tobacco cells (Nicotiana tabacum L. cv Wisconsin 38) synthesize a major 26 kilodalton protein which has been named osmotin due to its induction by low water potentials.	Sodium Chloride	29-33	osmotin	Nicotiana tabacum	159-166
16666857-3	1989	Abscisic acid induces messenger RNA encoding osmotin.	Abscisic Acid	0-13	osmotin	Nicotiana tabacum	45-52
16666857-6	1989	While abscisic acid induces the message for osmotin, a low water potential environment appears to be required for accumulation of the protein.	Abscisic Acid	6-19	osmotin	Nicotiana tabacum	44-51
16666857-9	1989	Osmotin is homologous to a 24 kilodalton NaCl-induced protein in tomato, as well as thaumatin, maize alpha-amylase/trypsin inhibitor and a tobacco mosaic virus-induced pathogenesis-related protein.	Sodium Chloride	41-45	osmotin	Nicotiana tabacum	0-7
33673090-7	2021	The results have clearly depicted that both transgenic lines overexpressing osmotin gene coped with increasing levels of NaCl by the induction of S metabolism, and particularly increase in OASTL activity closely paralleled changes of NaCl concentration.	Sodium Chloride	121-125	osmotin	Nicotiana tabacum	76-83
33673090-7	2021	The results have clearly depicted that both transgenic lines overexpressing osmotin gene coped with increasing levels of NaCl by the induction of S metabolism, and particularly increase in OASTL activity closely paralleled changes of NaCl concentration.	Sodium Chloride	234-238	osmotin	Nicotiana tabacum	76-83
28811634-2	2017	The therapeutic properties of osmotin have been explored in recent years as it exhibits neuroprotective effects against amyloid beta-, glutamate- and ethanol-induced synaptic dysfunction and neurodegeneration.	Ethanol	150-157	osmotin	Nicotiana tabacum	30-37
21311758-1	2011	Osmotin, a plant protein, specifically binds a seven transmembrane domain receptor-like protein to exert its biological activity via a RAS2/cAMP signaling pathway.	Cyclic AMP	140-144	osmotin	Nicotiana tabacum	0-7
26118757-4	2015	These results revealed that osmotin reverses Abeta1-42 injection-induced synaptic deficits, Abeta accumulation and BACE-1 expression.	UNII-042A8N37WH	45-50	osmotin	Nicotiana tabacum	28-35
26118757-5	2015	Treatment with osmotin also alleviated the Abeta1-42-induced hyperphosphorylation of the tau protein at serine 413 through the regulation of the aberrant phosphorylation of p-PI3K, p-Akt (serine 473) and p-GSK3beta (serine 9).	Serine	104-110	osmotin	Nicotiana tabacum	15-22
26118757-5	2015	Treatment with osmotin also alleviated the Abeta1-42-induced hyperphosphorylation of the tau protein at serine 413 through the regulation of the aberrant phosphorylation of p-PI3K, p-Akt (serine 473) and p-GSK3beta (serine 9).	Serine	188-194	osmotin	Nicotiana tabacum	15-22
26118757-5	2015	Treatment with osmotin also alleviated the Abeta1-42-induced hyperphosphorylation of the tau protein at serine 413 through the regulation of the aberrant phosphorylation of p-PI3K, p-Akt (serine 473) and p-GSK3beta (serine 9).	Serine	188-194	osmotin	Nicotiana tabacum	15-22
22936305-0	2012	Overexpression of tobacco osmotin (Tbosm) in soybean conferred resistance to salinity stress and fungal infections.	tbosm	35-40	osmotin	Nicotiana tabacum	26-33
20467880-0	2010	Overexpression of osmotin gene confers tolerance to salt and drought stresses in transgenic tomato (Solanum lycopersicum L.).	Salts	52-56	osmotin	Nicotiana tabacum	18-25
20467880-2	2010	In an attempt to develop salt and drought tolerant tomato, a DNA cassette containing tobacco osmotin gene driven by a cauliflower mosaic virus 35S promoter was transferred to tomato (Solanum lycopersicum) via Agrobacterium-mediated transformation.	Salts	25-29	osmotin	Nicotiana tabacum	93-100
20467880-8	2010	Results from different physiological tests demonstrated enhanced tolerance to salt and drought stresses in transgenic plants harboring the osmotin gene as compared to the wild-type plants.	Salts	78-82	osmotin	Nicotiana tabacum	139-146
20467880-10	2010	The present investigation clearly shows that overexpression of osmotin gene enhances salt and drought stress tolerance in transgenic tomato plants.	Salts	85-89	osmotin	Nicotiana tabacum	63-70
17086398-13	2007	The results show that osmotin is positively involved in the acclimation-related PCD, in blocking the cold-induced calcium signalling, and in affecting cytoskeleton in response to cold stimuli.	Calcium	114-121	osmotin	Nicotiana tabacum	22-29
21383921-3	2011	The osmotin induced proline accumulation has been reported to confer tolerance against both biotic and abiotic stresses in plants including transgenic tomato and strawberry overexpressing osmotin gene.	Proline	20-27	osmotin	Nicotiana tabacum	4-11
21383921-3	2011	The osmotin induced proline accumulation has been reported to confer tolerance against both biotic and abiotic stresses in plants including transgenic tomato and strawberry overexpressing osmotin gene.	Proline	20-27	osmotin	Nicotiana tabacum	188-195
21383921-4	2011	The exact mechanism of induction of proline by osmotin is however, not known till date.	Proline	36-43	osmotin	Nicotiana tabacum	47-54
15664187-3	2005	We show here that the protein encoded by ORE20/PHO36 (YOL002c), a seven transmembrane domain receptor-like polypeptide that regulates lipid and phosphate metabolism, is an osmotin binding plasma membrane protein that is required for full sensitivity to osmotin.	Phosphates	144-153	osmotin	Nicotiana tabacum	172-179
15664187-3	2005	We show here that the protein encoded by ORE20/PHO36 (YOL002c), a seven transmembrane domain receptor-like polypeptide that regulates lipid and phosphate metabolism, is an osmotin binding plasma membrane protein that is required for full sensitivity to osmotin.	Phosphates	144-153	osmotin	Nicotiana tabacum	253-260